The corridor task: striatal lesion effects and graft-mediated recovery in a model of Huntington's disease.
Experimental validation of cell replacement therapy as a treatment of neurodegenerative diseases requires the demonstration of graft-mediated behavioural recovery. The Corridor task proved to be simple and efficient to conduct with a robust ipsilateral retrieval bias in our rodent Huntington's disease model. The Corridor task is a viable behavioural option, particularly to non-specialised laboratories, for the evaluation of lateralised striatal damage and the probing of alternative therapeutic strategies, including transplantation.
Döbrössy
Máté D
MD
Brain Repair Group, School of Biosciences, Cardiff University, Museum Avenue Box 911, Cardiff CF10 3US, UK. dobrossymd@cf.ac.uk
Dunnett
Stephen B
SB
D000704:Analysis of Variance; D000818:Animals; D035841:Behavioral Research / Q000379:methods; D016380:Brain Tissue Transplantation; D004195:Disease Models, Animal; D053595:Embryonic Stem Cells / Q000637:transplantation*; D023381:Endpoint Determination; D005106:Exploratory Behavior / Q000502:physiology*; D005260:Female; D016332:Fetal Tissue Transplantation; D007839:Functional Laterality / Q000502:physiology; D006816:Huntington Disease / Q000628:therapy*; D017072:Neostriatum / Q000166:cytology / Q000196:embryology / Q000637:transplantation*; D051381:Rats; D017207:Rats, Sprague-Dawley; D020127:Recovery of Function / Q000502:physiology; D015203:Reproducibility of Results; D033581:Stem Cell Transplantation / Q000379:methods; D016896:Treatment Outcome