Four cases of Hb Q-H disease found in Southern China.
Four Chinese patients with Hb Q-H disease were identified during thalassemia screening. The main hematological characteristics of Hb Q-H disease are that Hb A is absent, and Hb Q-Thailand (also known as G-Taichung, Mahidol, Kurashiki-I and Asabara) accounts for the majority of the total hemoglobin (Hb). The phenotype of this disorder is similar to that of deletional Hb H (beta4) disease.
Li
Dongzhi
D
Prenatal Diagnostic Center, Guangzhou Maternal & Neonatal Hospital, Guangzhou Medical College, Guangzhou, Guangdong, PR China. dongzhi3@yahoo.com.cn
Liao
Can
C
Xie
Xingmei
X
Zhong
Huizhu
H
Li
Jian
J
D000328:Adult; D000740:Anemia / Q000209:etiology; D002681:China / Q000208:ethnology; D005260:Female; D006447:Hemoglobin H / Q000235:genetics* / Q000302:isolation & purification; D006455:Hemoglobins, Abnormal / Q000235:genetics*; D006801:Humans; D008297:Male; D008403:Mass Screening; D010641:Phenotype; D011247:Pregnancy; D011295:Prenatal Care; D017422:Sequence Analysis, DNA; D017085:alpha-Thalassemia / Q000150:complications / Q000235:genetics*
D006455:Hemoglobins, Abnormal; C049214:hemoglobin Q Thailand; D006447:Hemoglobin H