title: New bioactive natural products from Coprinus micaceus.
abstract: Chemical studies on the crude methanolic extract of Coprinus micaceus, collected from the Canadian Prairie region, have resulted in the isolation of two new natural products, micaceol (1), a sterol and (Z,Z)-4-oxo-2,5-hetpadienedioic acid (2). Compound 2 was isolated for the first time as a natural product. Structures of these new compounds were established with the aid of extensive NMR spectroscopic studies. Compound 1 has shown anti-bacterial activity against Corynebacterium xerosis and Staphylococcus aureus, whereas compound 2 exhibited glutathione S-transferase inhibition.
authors: Department of Chemistry, The University of Winnipeg, 515 Portage Avenue, Winnipeg, Manitoba, Canada R3B 2E9.
authors: Shamsulhaq
authors: S
authors: Zahid
authors: Chibuike C
authors: CC
authors: Udenigwe
authors: Athar
authors: A
authors: Ata
authors: Michael O
authors: MO
authors: Eze
authors: Edward P
authors: EP
authors: Segstro
authors: Paul
authors: P
authors: Holloway
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D002264:Carboxylic Acids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D003302:Coprinus / Q000737:chemistry*; D003352:Corynebacterium / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D005982:Glutathione Transferase / Q000037:antagonists & inhibitors; D008350:Manitoba; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009904:Optical Rotation; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013211:Staphylococcus aureus / Q000187:drug effects; D013261:Sterols / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D002264:Carboxylic Acids; D004791:Enzyme Inhibitors; D010936:Plant Extracts; D013261:Sterols; D005982:Glutathione Transferase