Maternal serum corticotropin-releasing hormone and ACTH levels as predictive markers of premature labor.
OBJECTIVE
To investigate whether corticotropin-releasing hormone (CRH) and corticotropin (ACTH) plasma concentrations in women diagnosed with preterm labor are of potential clinical value in the assessment of the risk of preterm birth.


METHODS
Plasma samples of 79 women diagnosed with preterm labor were used in this study. Samples were divided into three groups based on the week of gestation (24th-28th, 29th-32nd, 33rd-37th). CRH and ACTH values were determined by ELISA.


RESULTS
Mean maternal peripheral plasma values of CRH and ACTH were significantly higher (p<0.001) in women who were initially diagnosed with preterm labor and finally delivered a preterm birth, compared to women with the same diagnosis but with term birth.


CONCLUSIONS
CRH and ACTH serum levels in women diagnosed with preterm labor could be used as predictors for the timing of parturition.
Makrigiannakis
A
A
Laboratory of Human Reproduction, Department of Obstetrics & Gynecology, Medical School, University of Crete, Heraklion, Greece. makrigia@med.uoc.gr
Semmler
M
M
Briese
V
V
Eckerle
H
H
Minas
V
V
Mylonas
I
I
Friese
K
K
Jeschke
U
U
D000324:Adrenocorticotropic Hormone / Q000097:blood*; D000328:Adult; D015415:Biomarkers; D003346:Corticotropin-Releasing Hormone / Q000097:blood*; D005260:Female; D005865:Gestational Age; D006801:Humans; D007752:Obstetric Labor, Premature / Q000097:blood* / Q000503:physiopathology; D011237:Predictive Value of Tests; D011247:Pregnancy; D047928:Premature Birth / Q000175:diagnosis*
D015415:Biomarkers; D000324:Adrenocorticotropic Hormone; D003346:Corticotropin-Releasing Hormone