Correlation between haplotype of apolipoprotein B gene and natural longevity persons in Uygur nationality.
This paper investigated the correlation between polymorphisms and haplotypes in the apolipoprotein B (apoB) gene (SP-I/D, Xbal-RFLP, VNTR) and natural longevity persons among the Uygur people in Xinjiang. For this purpose, 191 healthy Uygur individuals aged above 90 from Hetian area of Xinjiang were recruited, and another 53 persons aged 65-70 from the same nationality, the same region and with the same gender ratio, served as the control group. Genotyping was performed by PCR-SSP, PCR-RFLP and PCR-sequencing methods. Logistic regression analyses revealed that the frequencies of X+ X+ genotype, M and L alleles and the genotypes composed of M and L were significantly higher in the longevity group than in the control group. In haplotype analyses, we found that, in the long-lived people, the frequency of haplotypes composed of the X+ and M alleles was significantly higher whereas the frequency of haplotypes composed of the X-and S alleles was significantly lower (both P<0.05) I than those of their controls. These results indicated that the S allele, SS genotype and X+-S, D-S, D-X+-S haplotypes were the possible adverse factors, whereas the M, L alleles, X+X+, MM, ML, LL genotypes and I-X+-M, X+-M haplotypes were the possible protective factors for the naturally long-lived Uygur people in China.
Jiang
WenXi
W
Xinjiang Medical University, Urumqi, 830054, China.
Qiu
ChangChun
C
Cheng
ZuHeng
Z
Zhou
WenYu
W
Gu
MingLiang
M
Xu
Qun
Q
Fang
MingWu
M
Niu
WenQuan
W
D000368:Aged; D000369:Aged, 80 and over; D001055:Apolipoproteins B / Q000235:genetics*; D002681:China; D005260:Female; D006239:Haplotypes; D006801:Humans; D008136:Longevity / Q000235:genetics*; D008297:Male
D001055:Apolipoproteins B