Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation.
It has been 30 years since a 'new' leukaemia termed adult T-cell leukaemia (ATL) was described in Japan, and more than 25 years since the isolation of the retrovirus, human T-cell leukaemia virus type 1 (HTLV-1), that causes this disease. We discuss HTLV-1 infectivity and how the HTLV-1 Tax oncoprotein initiates transformation by creating a cellular environment favouring aneuploidy and clastogenic DNA damage. We also explore the contribution of a newly discovered protein and RNA on the HTLV-1 minus strand, HTLV-1 basic leucine zipper factor (HBZ), to the maintenance of virus-induced leukaemia.
Matsuoka
Masao
M
Laboratory of Virus Immunology, Institute for Virus Research, Kyoto University, Japan.
Jeang
Kuan-Teh
KT
D000782:Aneuploidy; D050976:Basic-Leucine Zipper Transcription Factors / Q000235:genetics / Q000502:physiology*; D002471:Cell Transformation, Neoplastic; D002472:Cell Transformation, Viral; D004249:DNA Damage; D016356:Gene Products, tax; D015368:Human T-lymphotropic virus 1; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000473:pathology*; D008938:Mitosis; D008954:Models, Biological
D050976:Basic-Leucine Zipper Transcription Factors; D016356:Gene Products, tax