title: Doxorubicin-induced ventricular arrhythmia treated by implantation of an automatic cardioverter-defibrillator.
abstract: Anthracyclines are a group of potent antitumour agents and cardiotoxicity is an important factor limiting their therapeutic effectiveness. Although cardiomyopathy is the most widely recognized type of cardiotoxic reaction, early arrhythmia following anthracycline administration may be of clinical significance as well. We report a case of ventricular tachycardia causing cardiac arrest in a female treated with doxorubicin as adjuvant therapy of breast cancer. Due to recurrence of the arrhythmia and a desire to continue chemotherapy, an automatic cardioverter-defibrillator was implanted with excellent effect.
authors: 2nd Department of Cardiology, Medical University of Lodz, Kniaziewicza 1/5, 91-347 Lodz, Poland. tomek_rudzinski@op.pl
authors: Tomasz
authors: T
authors: Rudzinski
authors: Michal
authors: M
authors: Ciesielczyk
authors: Wojciech
authors: W
authors: Religa
authors: Zbigniew
authors: Z
authors: Bednarkiewicz
authors: Maria
authors: M
authors: Krzeminska-Pakula
mesh_terms: D018943:Anthracyclines / Q000009:adverse effects; D000903:Antibiotics, Antineoplastic / Q000009:adverse effects* / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy; D017147:Defibrillators, Implantable; D004317:Doxorubicin / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008875:Middle Aged; D012008:Recurrence; D017180:Tachycardia, Ventricular / Q000139:chemically induced* / Q000503:physiopathology / Q000628:therapy*
chemical_list: D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic; D004317:Doxorubicin