Design, calibration and evaluation of a robotic needle-positioning system for small animal imaging applications.
A needle-positioning robot has been developed for image-guided interventions in small animal research models. The device is designed to position a needle with an error < or =100 microm. The robot has two rotational axes (pitch and roll) to control needle orientation, and one linear axis to perform needle insertion. The three axes intersect at a single point to create a remote centre of motion (RCM) that acts as a fulcrum for the orientation of the needle. The RCM corresponds to the skin-entry point of the needle into the animal. The robot was calibrated to ensure that the three axes intersected at a single point defining an RCM and that the needle tip was positioned at the RCM. Needle-positioning accuracy and precision were quantified in Cartesian coordinates at ten target locations in the plane of each rotational axis. The measured needle-positioning accuracy in free space was 54 +/- 12 microm for the pitch axis plane and 91 +/- 21 microm for the roll axis plane. The measured needle-positioning precision was 15 and 17 microm for the pitch and roll axes planes, respectively. The robot's ability to insert a needle into a tumour in a euthanized mouse was demonstrated.
Waspe
Adam C
AC
Biomedical Engineering Graduate Program, University of Western Ontario, London, Ontario, N6A 5B9, Canada. awaspe@imaging.robarts.ca
Cakiroglu
H Jason
HJ
Lacefield
James C
JC
Fenster
Aaron
A
D000818:Animals; D001696:Biomechanical Phenomena; D002138:Calibration; D004195:Disease Models, Animal; D004867:Equipment Design; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000295:instrumentation* / Q000379:methods; D051379:Mice; D015233:Models, Statistical; D009339:Needles; D009369:Neoplasms / Q000532:radiotherapy*; D015203:Reproducibility of Results; D012371:Robotics; D025321:Surgery, Computer-Assisted / Q000295:instrumentation* / Q000379:methods; D014741:Video Recording