title: A novel approach to central venous catheter thrombosis in a patient with cystic fibrosis.
abstract: Catheter directed thrombolysis has been described as a treatment for large pulmonary emboli resistant to systemic therapy [Kelly P, Carroll N, Grant C, Barrett C, Kocka V. Successful treatment of massive pulmonary embolism with prolonged catheter-directed thrombolysis. Heart Vessels 2006;21:124?6]. We now describe a case in which local catheter directed thrombolysis, via a peripherally inserted central catheter (PICC), was used to treat a large thrombus surrounding the tip of an indwelling central venous line that was causing superior vena cava obstruction (SVCO), in a patient with cystic fibrosis.
authors: Knight Centre for Cystic Fibrosis, Frimley Park Hospital NHS Foundation Trust, Camberley, Surrey GU16 7UJ, UK.
authors: J H K
authors: JH
authors: Hull
authors: W
authors: W
authors: Tucker
authors: A G
authors: AG
authors: Hatrick
authors: R K
authors: RK
authors: Knight
authors: T B L
authors: TB
authors: Ho
mesh_terms: D000328:Adult; D002405:Catheterization, Central Venous / Q000009:adverse effects*; D003550:Cystic Fibrosis / Q000150:complications*; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D015912:Thrombolytic Therapy / Q000379:methods*; D013927:Thrombosis / Q000188:drug therapy* / Q000209:etiology*; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use
chemical_list: D005343:Fibrinolytic Agents; D006493:Heparin; D010959:Tissue Plasminogen Activator