title: HOMER2 binds MYO18B and enhances its activity to suppress anchorage independent growth.
abstract: MYO18B is a class XVIII myosin, cloned as a tumor suppressor gene candidate. To investigate the mechanisms of MYO18B-dependent tumor suppression, MYO18B-interacting proteins were searched for by a yeast two-hybrid screen. HOMER2, a Homer/Ves1 family protein, was identified as a binding partner of MYO18B. These proteins co-localized in the regions of membrane protrusion and stress fiber, which are known as ones with filamentous actin-rich structures. Expression of HOMER2 enhanced the ability of MYO18B to suppress anchorage-independent growth. These results indicate that HOMER2 and MYO18B cooperate together in tumor suppression.
authors: Biology Division, National Cancer Center Research Institute, 1-1, Tsukiji 5-chome, Chuo-ku, Tokyo 104-0045, Japan.
authors: Rieko
authors: R
authors: Ajima
authors: Keiko
authors: K
authors: Kajiya
authors: Takeshi
authors: T
authors: Inoue
authors: Masachika
authors: M
authors: Tani
authors: Yoko
authors: Y
authors: Shiraishi-Yamaguchi
authors: Masahiro
authors: M
authors: Maeda
authors: Tatsuya
authors: T
authors: Segawa
authors: Teiichi
authors: T
authors: Furuichi
authors: Kazuo
authors: K
authors: Sutoh
authors: Jun
authors: J
authors: Yokota
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism*; D002448:Cell Adhesion / Q000502:physiology*; D002462:Cell Membrane / Q000502:physiology*; D049109:Cell Proliferation; D000072233:Homer Scaffolding Proteins; D051379:Mice; D009218:Myosins / Q000378:metabolism*; D041681:NIH 3T3 Cells; D011485:Protein Binding; D025521:Tumor Suppressor Proteins / Q000378:metabolism*
chemical_list: D002352:Carrier Proteins; D000072233:Homer Scaffolding Proteins; C000606625:Homer2 protein, mouse; C500982:MYO18B protein, human; D025521:Tumor Suppressor Proteins; D009218:Myosins