title: Preparation, characterization, and optimization of pancreas-targeted 5-Fu loaded magnetic bovine serum albumin microspheres.
abstract: The magnetic bovine serum albumin (BSA) microspheres (MS) were prepared by emulsification/solidification method. In this experiment, two kinds of magnetic MS, e.g. BSA MS and PEG-incorporated BSA microspheres (PMS) were prepared. The obtained MS were characterized by Malvern laser particle sizer and scanning electron microscopy (SEM). The obtained MS were spherical and about 1.3 microm in size. The magnetic responsivity and in vitro release behavior of these MS were studied in detail. The in vivo distribution and targeting delivery of 5-fluorouracil (5-Fu) magnetic MS after artery administration were studied in rat. The results showed that PMS could efficiently delivery 5-Fu to the targeted site compared with BSA MS without PEG MS and free drug.
authors: State Key Laboratory of Biotherapy, West China Medical School, West China Hospital, Sichuan University, Chengdu, 610041, People's Republic of China.
authors: Wen Juan
authors: WJ
authors: Jia
authors: Jian Gang
authors: JG
authors: Liu
authors: Yang
authors: Y
authors: De Zhang
authors: Ji Wei
authors: JW
authors: Wang
authors: Jun
authors: J
authors: Wang
authors: Cheng Yi
authors: CY
authors: Sun
authors: Yi Feng
authors: YF
authors: Pan
authors: Chao
authors: C
authors: Yu
authors: Guo Zheng
authors: GZ
authors: Li
authors: Heng
authors: H
authors: Zhang
authors: Ma Ling
authors: ML
authors: Gou
authors: Ming Jing
authors: MJ
authors: Tu
authors: Zhi Yong
authors: ZY
authors: Qian
mesh_terms: D000818:Animals; D002417:Cattle; D002851:Chromatography, High Pressure Liquid; D005472:Fluorouracil / Q000008:administration & dosage*; D008280:Magnetics; D008863:Microspheres; D010179:Pancreas / Q000378:metabolism*; D012710:Serum Albumin, Bovine / Q000819:agonists*
chemical_list: D012710:Serum Albumin, Bovine; D005472:Fluorouracil