Single-dose chloral hydrate for benign convulsions with mild gastroenteritis.
OBJECTIVE
To reveal the efficacy of single-dose treatment with chloral hydrate (CH) for clustering seizures in benign convulsions with mild gastroenteritis.


METHODS
We retrospectively studied the details of treatment in 33 patients with ages ranging from 7 to 39 months. The time-series records of seizures and processes of drug administrations were investigated.


RESULTS
A single-dose therapy with CH was effective in 19 of 22 patients (86%), and diazepam in two of 16 (13%). The doses of CH in patients having a successful treatment with single-dose therapy ranged from 41.7 to 62.5 mg/kg (mean 50.2). In two patients, seizures were resistant to single-dose CH therapy, and their doses of CH were 33.8 and 35.1 mg/kg.


CONCLUSIONS
An advantage of the single-dose therapy with CH was shown. We recommend treatment with a sufficient dose of not less than 40 mg/kg of CH.
Enoki
Hideo
H
Department of Child Neurology, Seirei Hamamatsu General Hospital, Hamamatsu, Shizuoka, Japan. enoki@sis.seirei.or.jp
Yokota
Takuya
T
Nagasaki
Rika
R
Ohro
Yoichiro
Y
Takeda
Sho
S
Nakashima
Yasumi
Y
Matsubayashi
Rie
R
Matsubayashi
Tadashi
T
D000927:Anticonvulsants / Q000627:therapeutic use; D002675:Child, Preschool; D002697:Chloral Hydrate / Q000008:administration & dosage* / Q000627:therapeutic use; D015897:Comorbidity; D003975:Diazepam / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005260:Female; D005759:Gastroenteritis / Q000188:drug therapy* / Q000453:epidemiology; D006801:Humans; D007223:Infant; D007564:Japan / Q000453:epidemiology; D008297:Male; D012189:Retrospective Studies; D012640:Seizures / Q000188:drug therapy* / Q000453:epidemiology
D000927:Anticonvulsants; D002697:Chloral Hydrate; D003975:Diazepam