title: Memory consolidation or transformation: context manipulation and hippocampal representations of memory.
abstract: The traditional view is that the hippocampus is necessary for retaining memories until they are consolidated in their original form in the neocortex. An alternative view is that the original memory, which is hippocampus- and context-dependent, becomes transformed with time to one that is more schematic and independent of the hippocampus. By manipulating context in two protocols that are widely used to investigate hippocampal-neocortical interactions in memory, we find evidence for the transformation view.
authors: Rotman Research Institute, Baycrest Centre, 3560 Bathurst Street, Toronto, Ontario, M6A 2E1, Canada. gwinocur@rotman-baycrest.on.ca
authors: Gordon
authors: G
authors: Winocur
authors: Morris
authors: M
authors: Moscovitch
authors: Melanie
authors: M
authors: Sekeres
mesh_terms: D000818:Animals; D001522:Behavior, Animal; D003213:Conditioning, Psychological / Q000502:physiology*; D005239:Fear; D005508:Food Deprivation / Q000502:physiology; D005518:Food Preferences / Q000502:physiology; D006624:Hippocampus / Q000293:injuries / Q000502:physiology*; D008297:Male; D008568:Memory / Q000502:physiology*; D008959:Models, Neurological; D051381:Rats; D020318:Rats, Long-Evans; D012055:Reinforcement Schedule; D013997:Time Factors