title: The genotypes of GYPA and GYPB carrying the MNSs antigens are not associated with cerebral malaria.
abstract: Plasmodium falciparum invades erythrocytes via several routes using different red blood cell receptors that include glycophorin A (GYPA) and glycophorin B (GYPB). GYPA has two codominant alleles, i.e., M and N, that correspond to the M and N antigens, which differ by two amino acids (S1L, G5E); the codominant alleles of GYPB, i.e., S and s, correspond to the S and s antigens, which differ by a single amino acid (T29M). If these antigens influence the efficiency of erythrocyte invasion by malaria parasites, the MNSs phenotype may be associated with the severity of malaria. To examine this, the GYPA and GYPB genotypes carrying the MNSs antigens were analyzed in 109 and 203 Thai patients with cerebral malaria and mild malaria, respectively. Neither the genotype nor allele frequencies at each locus were statistically different between the cerebral and mild malaria patients. Thus, we conclude that the MNSs antigens do not reveal the difference in susceptibility to cerebral malaria.
authors: Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
authors: Izumi
authors: I
authors: Naka
authors: Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan. juno-tky@umin.ac.jp.
authors: Jun
authors: J
authors: Ohashi
authors: Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
authors: Jintana
authors: J
authors: Patarapotikul
authors: Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
authors: Hathairad
authors: H
authors: Hananantachai
authors: Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
authors: Polrat
authors: P
authors: Wilairatana
authors: Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
authors: Sornchai
authors: S
authors: Looareesuwan
authors: Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
authors: Katsushi
authors: K
authors: Tokunaga
mesh_terms: D001789:Blood Group Antigens / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006021:Glycophorins / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D016779:Malaria, Cerebral / Q000235:genetics*; D016778:Malaria, Falciparum / Q000097:blood / Q000235:genetics*; D013785:Thailand
chemical_list: D001789:Blood Group Antigens; C409972:GYPA protein, human; C409973:GYPB protein, human; D006021:Glycophorins