Fluorinated NSC as a Cdc25 inhibitor.
We report on the fluorinated form of NSC 95397 as a Cdc25B inhibitor, which is predicted to be only an arylator of cysteine-containing proteins, without generating reactive oxygen species.
Park
Hwangseo
H
Department of Bioscience and Biotechnology, Sejong University, 98 Kunja-Dong, Kwangjin-Ku, Seoul 143-747, Republic of Korea.
Carr
Brian I
BI
Li
Minghua
M
Ham
Seung Wook
SW
D000970:Antineoplastic Agents / Q000737:chemistry*; D001665:Binding Sites; D018797:Cell Cycle Proteins / Q000037:antagonists & inhibitors*; D002863:Chromogenic Compounds; D005461:Fluorine; D007700:Kinetics; D008958:Models, Molecular; D009285:Naphthoquinones / Q000737:chemistry* / Q000494:pharmacology*; D011485:Protein Binding; D013816:Thermodynamics; D020687:cdc25 Phosphatases / Q000037:antagonists & inhibitors*
C451261:2,3-bis(2-hydroxyethylsulfanyl)-(1,4)naphthoquinone; D000970:Antineoplastic Agents; D018797:Cell Cycle Proteins; D002863:Chromogenic Compounds; D009285:Naphthoquinones; D005461:Fluorine; D020687:cdc25 Phosphatases