Proliferative activity of cells in mouse thymus and spleen under different diurnal regimens of interleukin-2 administration.
Circadian variations in spontaneous and concanavalin A-stimulated proliferation of mouse thymocytes and splenocytes were studied after administration of recombinant interleukin-2 at different times of day. Differences were revealed in the effect of morning and evening treatment with the cytokine. The time of injection corresponded to various phases of the natural circadian rhythm of endogenous interleukin-2 production, which probably contributes to diurnal differences in the influence of this cytokine.
Kovshik
I G
IG
Institute of Clinical and Experimental Lymphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk.
Silkov
A N
AN
Sennikov
S V
SV
Shurlygina
A V
AV
Trufakin
V A
VA
D000704:Analysis of Variance; D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects*; D019454:Chronotherapy / Q000379:methods*; D007376:Interleukin-2 / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D013154:Spleen / Q000166:cytology*; D013936:Thymidine; D013950:Thymus Gland / Q000166:cytology*; D014316:Tritium
D007376:Interleukin-2; D014316:Tritium; D013936:Thymidine