title: Achieving conformational control over C-C, C-N and C-O bonds in biaryls, N,N'-diarylureas and diaryl ethers: advantages of a relay axis.
abstract: The orientation of Ar-C, Ar-N and Ar-O bonds in biaryls, N,N'-diarylureas and diaryl ethers (whose conformers are distinguishable by NMR) may be controlled with a selectivity up to >95 : 5 by an adjacent stereogenic centre; the selectivity may be greater when a second stereogenic axis is inserted between the controlling centre and the slowly rotating bond.
authors: School of Chemistry, University of Manchester, Oxford Road, Manchester, UKM13 9PL.
authors: Mark S
authors: MS
authors: Betson
authors: Ann
authors: A
authors: Bracegirdle
authors: Jonathan
authors: J
authors: Clayden
authors: Madeleine
authors: M
authors: Helliwell
authors: Andrew
authors: A
authors: Lund
authors: Mark
authors: M
authors: Pickworth
authors: Timothy J
authors: TJ
authors: Snape
authors: Christopher P
authors: CP
authors: Worrall
mesh_terms: D004987:Ethers / Q000737:chemistry; D006841:Hydrocarbons, Aromatic / Q000138:chemical synthesis* / Q000737:chemistry; D008968:Molecular Conformation; D009930:Organic Chemicals / Q000138:chemical synthesis / Q000737:chemistry; D014508:Urea / Q000737:chemistry
chemical_list: D004987:Ethers; D006841:Hydrocarbons, Aromatic; D009930:Organic Chemicals; D014508:Urea