title: The use of intra-articular hylan G-F 20 in the treatment of symptomatic osteoarthritis of the shoulder: a preliminary study.
abstract: BACKGROUND
  While hylan G-F 20 is an approved therapy for the treatment of knee osteoarthritis, there are few reports of its use in shoulder osteoarthritis.
  
  
  OBJECTIVE
  Hylan G-F 20 can reduce pain and improve function in patients with glenohumeral osteoarthritis.
  
  
  METHODS
  Case series; Level of evidence, 4.
  
  
  METHODS
  Thirty consecutive patients with idiopathic glenohumeral osteoarthritis who failed to respond to standard conservative measures were enrolled. Patients received 3 weekly intra-articular hylan G-F 20 injections in their affected shoulder and completed a visual analog scale for pain, the UCLA score, and the Simple Shoulder Test at baseline and at 1, 3, and 6 months after the third injection.
  
  
  RESULTS
  Of the 30 patients, 3 withdrew during the washout period before treatment; the remaining patients (17 men and 10 women) had an average age of 62 years. The mean baseline visual analog scale score was 54, UCLA score was 15.7, and Simple Shoulder Test score was 5.7 (of 12 possible "yes" responses). At the 6-month follow-up, hylan G-F 20 significantly improved visual analog scale (mean 30, P < .001), UCLA (mean 24, P < .001), and Simple Shoulder Test (7.6 "yes" responses, P < .001) scores. More patients slept comfortably after treatment (56%) versus before treatment (15%). Nine patients had a visual analog scale improvement >40 points after 6 months. No device-related adverse events were observed.
  
  
  CONCLUSIONS
  Hylan G-F 20 may have a beneficial therapeutic effect on some symptomatic patients with glenohumeral osteoarthritis.
authors: Department of Orthopaedic Surgery, University of Connecticut Health Center, Farmington, CT 06034-4037, USA.
authors: Eric
authors: E
authors: Silverstein
authors: Robin
authors: R
authors: Leger
authors: Kevin P
authors: KP
authors: Shea
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology / Q000627:therapeutic use*; D000368:Aged; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000494:pharmacology / Q000627:therapeutic use*; D007270:Injections, Intra-Articular; D008875:Middle Aged; D010003:Osteoarthritis / Q000188:drug therapy*; D017063:Outcome Assessment, Health Care; D012785:Shoulder Joint / Q000187:drug effects* / Q000503:physiopathology; D014481:United States
chemical_list: D000276:Adjuvants, Immunologic; D006820:Hyaluronic Acid