Comparison of lactated Ringer's solution and 0.9% saline in the treatment of rhabdomyolysis induced by doxylamine intoxication.
OBJECTIVE
To compare the effectiveness and side effects of lactated Ringer's solution (LR) and 0.9% saline (NS) in the treatment of rhabdomyolysis induced by doxylamine intoxication.


METHODS
In this 15-month-long prospective randomised single-blind study, after excluding 8 patients among 97 doxylamine-intoxicated patients, 28 (31%) patients were found to have developed rhabdomyolysis and were randomly allocated to NS group (n = 15) or LR group (n = 13).


RESULTS
After 12 h of aggressive hydration (400 ml/h), urine/serum pH was found to be significantly higher in the LR group, and serum Na+/Cl- levels to be significantly higher in the NS group. There were no significant differences in serum K+ level and in the time taken for creatine kinase normalisation. The amount of sodium bicarbonate administered and the frequency administration of diuretics was significantly higher in the NS group. Unlike the NS group, the LR group needed little supplemental sodium bicarbonate and did not develop metabolic acidosis.


CONCLUSIONS
LR is more useful than NS in the treatment of rhabdomyolysis induced by doxylamine intoxication.
Cho
Young Soon
YS
Department of Emergency Medicine, Soonchunhyang University Bucheon Hospital, 1174, Jung-dong, Wonmi-gu, Bucheon-si, Gyeonggi-do 420-020, Republic of Korea. choyoungsoon@hanafos.com
Lim
Hoon
H
Kim
Seung Ho
SH
D000328:Adult; D004319:Doxylamine / Q000506:poisoning*; D005260:Female; D005440:Fluid Therapy / Q000379:methods*; D006634:Histamine H1 Antagonists / Q000506:poisoning*; D006801:Humans; D007552:Isotonic Solutions / Q000627:therapeutic use*; D008297:Male; D011446:Prospective Studies; D012206:Rhabdomyolysis / Q000139:chemically induced* / Q000628:therapy*; D000077325:Ringer's Lactate; D016037:Single-Blind Method; D012965:Sodium Chloride / Q000627:therapeutic use*; D018709:Statistics, Nonparametric; D016896:Treatment Outcome
D006634:Histamine H1 Antagonists; D007552:Isotonic Solutions; D000077325:Ringer's Lactate; D012965:Sodium Chloride; D004319:Doxylamine