title: Plasma annexin A5 level relates inversely to the severity of coronary stenosis.
abstract: Exogenous radiolabeled annexin A5 is taken up by atherosclerotic tissue. We measured endogenous plasma annexin A5 and circulating oxidized low-density lipoprotein (oxLDL), a biochemical marker of atherosclerosis, in men with either severe angiographically determined coronary stenosis (n=90) or no or only minor stenosis (n=96). Men without history of cardiac disease or treatment and free of plaques in the carotid artery (by ultrasonography) were taken as controls (n=87). Opposite to oxLDL, annexin A5 decreased at increasing severity of stenosis. OxLDL was lowest and annexin A5 was highest in controls. Percentage differences between groups were higher for annexin A5 than for oxLDL, and highest for oxLDL/annexin A5 ratio. The oxLDL/annexin A5 ratio is a better marker of the severity of coronary stenosis than oxLDL alone, may reflect the presence and extent of the atherosclerotic cardiovascular disease, and might prove useful for preclinical screening purposes.
authors: Department of General Internal Medicine 441, Radboud University Nijmegen Medical Centre, 6525 GA Nijmegen, 6500 HB Nijmegen, The Netherlands. B.vantits@aig.umcn.nl
authors: Lambertus J H
authors: LJ
authors: van Tits
authors: Waander L
authors: WL
authors: van Heerde
authors: Gerly M
authors: GM
authors: van der Vleuten
authors: Jacqueline
authors: J
authors: de Graaf
authors: Diederick E
authors: DE
authors: Grobbee
authors: Lucy P L
authors: LP
authors: van de Vijver
authors: Anton F
authors: AF
authors: Stalenhoef
authors: Hans M
authors: HM
authors: Princen
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D017304:Annexin A5 / Q000097:blood*; D002097:C-Reactive Protein / Q000032:analysis; D002339:Carotid Arteries / Q000000981:diagnostic imaging; D015331:Cohort Studies; D017023:Coronary Angiography; D023921:Coronary Stenosis / Q000097:blood* / Q000473:pathology; D006801:Humans; D017270:Lipoprotein(a) / Q000032:analysis; D008077:Lipoproteins, LDL / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D014463:Ultrasonography
chemical_list: D017304:Annexin A5; D017270:Lipoprotein(a); D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein; D002097:C-Reactive Protein