Pharmacokinetic profile of cocaine following intravenous administration in the female rabbit.
Prenatal cocaine exposure in a rabbit intravenous model has revealed selective disruption of brain development and pharmacological responsiveness. We therefore examined the pharmacokinetic properties of cocaine in this model. Dutch-belted rabbits were surgically implanted with a catheter in the carotid artery, allowed to recover, and then injected intravenously with a cocaine bolus. Cocaine and benzoylecgonine concentrations were measured in arterial blood plasma and analyzed by nonlinear regression and noncompartmental analyses. Peak cocaine concentration occurred by 30s, was transient, and distribution was rapid. The profile of cocaine in the rabbit is similar to that observed in humans using cocaine at recreational doses.
Parlaman
Joshua P
JP
Department of Pharmacology, Vanderbilt University School of Medicine, Nashville TN 37232, United States.
Thompson
Barbara L
BL
Levitt
Pat
P
Stanwood
Gregg D
GD
D000818:Animals; D019540:Area Under Curve; D000697:Central Nervous System Stimulants / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics*; D003042:Cocaine / Q000008:administration & dosage* / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics*; D005260:Female; D006207:Half-Life; D007275:Injections, Intravenous; D008954:Models, Biological; D017711:Nonlinear Dynamics; D011817:Rabbits
D000697:Central Nervous System Stimulants; C005618:benzoylecgonine; D003042:Cocaine