Plasma serotonin levels are normal in pulmonary arterial hypertension.
Serotonin (5-HT) has been implicated in the pathogenesis of pulmonary arterial hypertension (PAH). We hypothesized that plasma 5-HT would be elevated in PAH related to associated conditions. We performed a prospective cohort study of 21 patients with PAH undergoing initial right heart catheterization and 6 healthy controls. Platelet-free plasma 5-HT levels were similar in patients with idiopathic PAH, PAH related to associated conditions, and healthy controls. Higher 5-HT levels correlated with increased six-minute walk distance (r=0.55, p=0.04). These data suggest that plasma 5-HT levels are normal in PAH. Plasma 5-HT may therefore not be a useful biomarker in this condition.
Lederer
David J
DJ
Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA.
Horn
Evelyn M
EM
Rosenzweig
Erika B
EB
Karmally
Wahida
W
Jahnes
Megan
M
Barst
Robyn J
RJ
Kawut
Steven M
SM
D000328:Adult; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012701:Serotonin / Q000097:blood*
D012701:Serotonin