Intrapartum amnioinfusion for meconium-stained amniotic fluid: a systematic review of randomised controlled trials.
BACKGROUND
Amnioinfusion (AI) is thought to dilute meconium when present in the amniotic fluid and so reduces the risk of meconium aspiration.


OBJECTIVE
To evaluate if AI reduces meconium aspiration syndrome (MAS) and other indicators of morbidity in babies born to women with meconium-stained amniotic fluid (MSAF).


METHODS
PubMed, Medline, EMBASE, and the Cochrane Controlled Trials Register from January 1980 to May 30, 2005, using the keywords 'amnioinfusion' and 'meconium'.


METHODS
Randomised trials comparing AI with no AI for women in labour with MSAF. Trial quality was evaluated using pre-established criteria.


METHODS
The following morbidity indicators were assessed: MAS, 5-minute Apgar score < 7, arterial cord pH < 7.2, and caesarean section. Studies were stratified according to the level of peripartum surveillance (standard versus limited). Typical relative risks (RRs) with their 95% confidence intervals were calculated for each outcome using a random effects model.


RESULTS
In clinical settings with standard peripartum surveillance, we found no evidence that AI reduced the risk of MAS (RR 0.59, 95% CI 0.28-1.25), 5-minute Apgar score < 7 (RR 0.90, 95% CI 0.58-1.41), or caesarean delivery (RR 0.89, 95% CI 0.73-1.10). In clinical settings with limited peripartum surveillance, AI appeared to reduce the risk of MAS (RR 0.25, 95% CI 0.13-0.47).


CONCLUSIONS
In clinical settings with standard peripartum surveillance, the evidence does not support the use of AI for MSAF. In settings with limited peripartum surveillance, where complications of MSAF are common, AI appears to reduce the risk of MAS. However, this finding requires confirmation by further studies.
Xu
H
H
Department of Obstetrics & Gynecology, Université de Montréal/Hôpital Sainte-Justine, Montreal, Quebec, Canada.
Hofmeyr
J
J
Roy
C
C
Fraser
W  D
W
D000650:Amnion; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008471:Meconium Aspiration Syndrome / Q000517:prevention & control / Q000628:therapy*; D007744:Obstetric Labor Complications / Q000628:therapy*; D011247:Pregnancy; D011256:Pregnancy Outcome; D011295:Prenatal Care / Q000379:methods*; D016032:Randomized Controlled Trials as Topic