title: 99Tcm-DISIDA hepatobiliary imaging in evaluating gallbladder function in patients with spinal cord injury.
abstract: BACKGROUND
  Spinal cord injury (SCI) is associated with increased prevalence of gallstones and acute acalculous cholecystitis. A possible explanation for the increased prevalence of gallstones in SCI patients is decreased gallbladder motility causing gallbladder stasis. In this study, we investigated gallbladder function in patients with SCI.
  
  
  METHODS
  Eighteen normal controls, 16 trauma controls and 46 SCI patients were included in this study. Gallbladder function was measured by technium 99m-labeled imino-diacetic acid analogue ((99)Tc(m)-DISIDA) hepatobiliary imaging and represented by filling fraction (FF) and ejection fraction (EF). The data from SCI patients were analyzed according to old versus young, female versus male, heavy versus light body weight, ASIA A & B versus ASIA C & D classification, high- versus low-level injury, and long versus short injury duration.
  
  
  RESULTS
  Fifty-two percent of SCI patients had abnormal FF and 59% had abnormal EF. Significantly decreased FF and EF values were found in SCI patients, especially in female patients with severe and high-level injuries.
  
  
  CONCLUSIONS
  Quantitative (99)Tc(m)-DISIDA cholescintigraphy showed that SCI can significantly impair gallbladder function.
authors: Department of Orthopaedics, Affiliated Hospital, Qingdao University Medical College, Qingdao, China. xcs009@163.com
authors: Chang-Suo
authors: CS
authors: Xia
authors: Xuan-Ying
authors: XY
authors: Yang
authors: Guang-Xiang
authors: GX
authors: Hong
mesh_terms: D000328:Adult; D041761:Cholecystolithiasis / Q000209:etiology; D005260:Female; D005704:Gallbladder / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D006801:Humans; D008297:Male; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D013119:Spinal Cord Injuries / Q000150:complications / Q000503:physiopathology*; D019785:Technetium Tc 99m Disofenin
chemical_list: D019275:Radiopharmaceuticals; D019785:Technetium Tc 99m Disofenin