[Restenosis after coronary angioplasty: pathomechanism and potential targets for therapeutic intervention. Focus on inflammation].
Percutaneous transluminal coronary angioplasty has become the most widely implemented method of heart revascularization. Despite many advances, such as application of bare metal stents, high-pressure inflation, and the recent invention of drug-eluting stents, restenosis remains the major limitation of invasive cardiology and is associated with a significant number or target lesion re-interventions. This review highlights contemporary concepts of the pathogenesis of coronary restenosis and potential targets for therapeutic intervention, with a special emphasis on the role of inflammation and distinctions in vessel re-narrowing patterns after balloon angioplasty and both bare metal and drug-eluting stenting.
Koziński
Marek
M
Katedra i Klinika Kardiologii i Chorób Wewnetrznych, Collegium Medicum im. Ludwika Rydygiera w Bydgoszczy, Uniwersytet Mikołaja Kopernika w Toruniu. marekkozinski@wp.pl
Sukiennik
Adam
A
Rychter
Marcin
M
Kubica
Jacek
J
Sinkiewicz
Władysław
W
D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects*; D001167:Arteritis / Q000209:etiology / Q000628:therapy; D023903:Coronary Restenosis / Q000209:etiology* / Q000503:physiopathology* / Q000628:therapy; D006801:Humans; D015607:Stents / Q000009:adverse effects