Commuting (to) suicide: an update on nucleocytoplasmic transport in apoptosis.
Commuting is the process of travelling between a place of residence and a place of work. In the context of biology, this expression evokes the continuous movement of macromolecules between different compartments of a eukaryotic cell. Transport in and out of the nucleus is a major example of intracellular commuting. This article discusses recent findings that substantiate the emerging link between nucleocytoplasmic transport and the signalling and execution of cell death.
Grote
Patricia
P
University of Konstanz, Department of Biology, Molecular Toxicology, P.O. Box X911, D-78457 Konstanz, Germany.
Schaeuble
Karin
K
Ferrando-May
Elisa
E
D021581:Active Transport, Cell Nucleus / Q000502:physiology*; D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D051017:Apoptosis Regulatory Proteins / Q000378:metabolism*; D020169:Caspases / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D029543:Nucleocytoplasmic Transport Proteins / Q000378:metabolism*; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000502:physiology*; D017382:Reactive Oxygen Species
D051017:Apoptosis Regulatory Proteins; D029543:Nucleocytoplasmic Transport Proteins; D017382:Reactive Oxygen Species; D020169:Caspases