Factors that influence characteristics of genetic biobanks.
OBJECTIVE
To identify demographic differences between patients who choose participation and patients who choose nonparticipation in genetic biobanks, and to explore reasons for nonparticipation.


METHODS
Prospective study of hospitalized cardiovascular patients approached to participate in a genetic biobank, 300 nonparticipants and 299 participants, in the southwestern US.


METHODS
Reasons for nonparticipation were explored. Logistic regression was performed to determine if gender, race or ethnicity, or age predicted nonparticipation.


RESULTS
Race or ethnicity and age were significantly different between participants and nonparticipants, but gender was not. Blood-sample collection was the main reason for declining participation.


CONCLUSIONS
Minority and older adults were less likely to participate. Understanding reasons for nonparticipation in this group might aid in the development of methods used to obtain a diverse population in biobanks.
Sanner
Jennifer E
JE
University of Texas Health Science Center at Houston, School of Nursing, USA.
Frazier
Lorraine
L
D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001800:Blood Specimen Collection / Q000009:adverse effects / Q000523:psychology; D002318:Cardiovascular Diseases / Q000523:psychology*; D030561:Databases, Nucleic Acid / Q000458:organization & administration; D005006:Ethnicity / Q000523:psychology; D005260:Female; D030661:Genetic Privacy; D007722:Health Knowledge, Attitudes, Practice; D006301:Health Services Needs and Demand; D006801:Humans; D007297:Inpatients / Q000523:psychology* / Q000706:statistics & numerical data; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D008960:Models, Psychological; D009042:Motivation; D015404:Nursing Methodology Research; D010342:Patient Acceptance of Health Care / Q000523:psychology* / Q000706:statistics & numerical data; D011446:Prospective Studies; D012372:ROC Curve; D012307:Risk Factors; D015206:Southwestern United States