title: [Hypertonic saline solution for reduction of intracranial pressure. Are there doubts?].
abstract: Osmotherapy, i.e. the intravenous administration of hyperosmolar solutions, is one of the mainstays of therapy for reduction of a pathologically increased intracranial pressure, in addition to analgosedation and raising the upper body of the patient. The administration of mannitol as a osmotherapeutic agent is, however, marred by considerable side-effects. A possible alternative is the use of hypertonic saline solution (NaCl). The advantages and disadvantages of this option are considered as well as points still in question.
authors: Klinik und Poliklinik für Anästhesie und Intensivtherapie, Universitätsklinik Carl Gustav Carus der Technischen Universität Dresden, Fetscherstrasse 74, 01307 Dresden. Hermann.Theilen@uniklinikum-dresden.de
authors: H
authors: H
authors: Theilen
authors: M
authors: M
authors: Ragaller
authors: T
authors: T
authors: Koch
mesh_terms: D006801:Humans; D019586:Intracranial Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D007427:Intracranial Pressure / Q000187:drug effects* / Q000502:physiology; D008353:Mannitol / Q000009:adverse effects / Q000627:therapeutic use; D012462:Saline Solution, Hypertonic / Q000627:therapeutic use*
chemical_list: D012462:Saline Solution, Hypertonic; D008353:Mannitol