Linking the epigenetic 'language' of covalent histone modifications to cancer.
Covalent modifications of histones, such as acetylation, methylation, and phosphorylation, and other epigenetic modulations of the chromatin, such as methylation of DNA and ATP-dependent chromatin reorganisation, can play a major part in the multistep process of carcinogenesis, with far-reaching implications for human biology and human health. This review focuses on how aberrant covalent histone modifications may contribute to the development of a variety of human cancers, and discusses the recent findings with regard to potential therapies.
Hake
S B
SB
Laboratory of Chromatin Biology, The Rockefeller University, New York, NY 10021, USA
Xiao
A
A
Allis
C D
CD