Russell body gastritis: expanding the spectrum of Helicobacter pylori - related diseases?
We report a new case of Helicobacter pylori gastritis showing plasma cell infiltrates with extensive formation of Russell bodies (Mott cells) within the lamina propria of the antral mucosa. The patient was a 60-year-old woman with a history of epigastric pain. Endoscopy revealed non-specific congestion of the mucosa. Microscopically, the intracytoplasmic inclusions were homogeneous, mainly round to oval, and pushed the nucleus toward the periphery. They were intensely PAS-positive and reacted to antibodies against polytypic light chains, CD79a, and anti-plasma cell antibody. Because of the accumulation of intracytoplasmic inclusions, Russell body gastritis is a potential source of diagnostic difficulties in endoscopic biopsy specimens that can be confused with immunocytic neoplasms, such as lymphoplasmacytic lymphoma or plasmocytoma, or signet-ring cell carcinoma. In the light of similar cases published previously, it seems as if the association between Russell body gastritis and Helicobacter pylori infection is not merely coincidental.
Pizzolitto
Stefano
S
Department of Pathology, General Hospital S. Maria della Misericordia, Udine, Italy.
Camilot
Debora
D
DeMaglio
Giovanna
G
Falconieri
Giovanni
G
D051925:CD79 Antigens / Q000032:analysis; D005260:Female; D005753:Gastric Mucosa / Q000276:immunology / Q000473:pathology / Q000821:virology; D005756:Gastritis / Q000276:immunology / Q000473:pathology / Q000821:virology*; D016481:Helicobacter Infections / Q000150:complications* / Q000276:immunology / Q000473:pathology / Q000821:virology; D016480:Helicobacter pylori / Q000302:isolation & purification*; D006801:Humans; D007145:Immunoglobulin kappa-Chains / Q000032:analysis; D007146:Immunoglobulin lambda-Chains / Q000032:analysis; D007181:Inclusion Bodies, Viral / Q000473:pathology; D008875:Middle Aged; D010503:Periodic Acid-Schiff Reaction; D010950:Plasma Cells / Q000276:immunology / Q000473:pathology / Q000821:virology*; D011706:Pyloric Antrum / Q000276:immunology / Q000473:pathology / Q000821:virology*
D051925:CD79 Antigens; C497881:CD79A protein, human; D007145:Immunoglobulin kappa-Chains; D007146:Immunoglobulin lambda-Chains