title: FDG-PET study of the bilateral subthalamic nucleus stimulation effects on the regional cerebral metabolism in advanced Parkinson disease.
abstract: The aim of the study was to evaluate the changes in regional cerebral metabolic rate of glucose (rCMRGlu) induced by bilateral subthalamic nucleurs (STN) stimulation in advanced Parkinson's disease (PD). 18F-Fluorodeoxyglucose (FDG) PET data obtained before and one month after stimulation were analyzed with statistical parametric mapping (SPM). As a result of clinically effective bilateral STN stimulation, rCMRGlu increased in lateral globus pallidus (GP), upper brain stem, dorsolateral prefrontal cortex (DLPFC) and posterior parietal-occipital cortex, and decreased in the orbital frontal cortex and parahippocampus gyrus (p < 0.001). We conclude that the alleviation of clinical symptoms in advanced PD by bilateral STN stimulation may be the result of activation of both ascending and descending pathways from STN and of restoration of the impaired higher-order cortex functions.
authors: Department of Neurosurgery, Shanghai Second Medical University Ruijin Hospital, Shanghai, P.R. China.
authors: D
authors: D
authors: Li
authors: C
authors: C
authors: Zuo
authors: Y
authors: Y
authors: Guan
authors: Y
authors: Y
authors: Zhao
authors: J
authors: J
authors: Shen
authors: S
authors: S
authors: Zan
authors: B
authors: B
authors: Sun
mesh_terms: D000978:Antiparkinson Agents / Q000627:therapeutic use; D001921:Brain / Q000378:metabolism; D001931:Brain Mapping; D046690:Deep Brain Stimulation / Q000379:methods*; D004305:Dose-Response Relationship, Drug; D019788:Fluorodeoxyglucose F18; D005500:Follow-Up Studies; D007839:Functional Laterality; D006801:Humans; D007258:Informed Consent; D007980:Levodopa; D010300:Parkinson Disease / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000601:surgery*; D049268:Positron-Emission Tomography / Q000379:methods*; D011300:Preoperative Care; D011859:Radiography; D019275:Radiopharmaceuticals; D020531:Subthalamic Nucleus / Q000000981:diagnostic imaging* / Q000601:surgery*
chemical_list: D000978:Antiparkinson Agents; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D007980:Levodopa