State of stem cell pools in experimental diabetes mellitus.
We studied the state of pools of mesenchymal precursor cells of different maturity in the bone marrow and peripheral blood and the dynamics of the content of regional parenchymal stem cells and stromal precursors in the pancreas during experimental diabetes mellitus. Reduced content of organ-specific stem cells and increased content of stromal precursors in the pancreas in the absence of compensatory reaction of deep reserve mechanisms, mesenchymal bone marrow cells, were revealed.
Goldberg
E D
ED
Institute of Pharmacology, Tomsk Research Center, Siberian Division of Russian Academy of Medical Sciences.
Dygai
A M
AM
Zhdanov
V V
VV
Zyuz'kov
G N
GN
Fomina
T I
TI
Ermolaeva
L A
LA
Gur'yantseva
L A
LA
Khrichkova
T Yu
TY
Vetoshkina
T V
TV
D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology*; D003921:Diabetes Mellitus, Experimental / Q000473:pathology*; D005260:Female; D006652:Histological Techniques; D007091:Image Processing, Computer-Assisted; D008297:Male; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D051379:Mice; D008808:Mice, Inbred CBA; D010179:Pancreas / Q000166:cytology*; D018709:Statistics, Nonparametric; D013997:Time Factors