title: iPTREE-STAB: interpretable decision tree based method for predicting protein stability changes upon mutations.
abstract: We have developed a web server, iPTREE-STAB for discriminating the stability of proteins (stabilizing or destabilizing) and predicting their stability changes (delta deltaG) upon single amino acid substitutions from amino acid sequence. The discrimination and prediction are mainly based on decision tree coupled with adaptive boosting algorithm, and classification and regression tree, respectively, using three neighboring residues of the mutant site along N- and C-terminals. Our method showed an accuracy of 82% for discriminating the stabilizing and destabilizing mutants, and a correlation of 0.70 for predicting protein stability changes upon mutations.
  
  
  BACKGROUND
  http://bioinformatics.myweb.hinet.net/iptree.htm.
  
  
  BACKGROUND
  Dataset and other details are given.
authors: Department of Computer Science and Information Engineering, Ming-Dao University, Changhua 523, Taiwan.
authors: Liang-Tsung
authors: LT
authors: Huang
authors: M Michael
authors: MM
authors: Gromiha
authors: Shinn-Ying
authors: SY
authors: Ho
mesh_terms: D000465:Algorithms; D019943:Amino Acid Substitution; D009154:Mutation; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry* / Q000235:genetics; D013816:Thermodynamics
chemical_list: D011506:Proteins