Asymmetric hydrogenation of enol phosphinates by iridium catalysts having N,P ligands.
[reaction: see text] Enol phosphinates, which are structural analogues of enol acetates, have for the first time been employed as substrates for Ir-catalyzed asymmetric hydrogenation. A number of enol phosphinates have been synthesized and reduced successfully with up to and above 99% ee.
Cheruku
Pradeep
P
Department of Biochemistry and Organic Chemistry, Box 576, SE-751 23, Uppsala, Sweden.
Gohil
Suresh
S
Andersson
Pher G
PG
D002384:Catalysis; D006865:Hydrogenation; D007495:Iridium / Q000737:chemistry*; D008024:Ligands; D015394:Molecular Structure; D009584:Nitrogen / Q000737:chemistry*; D010721:Phosphinic Acids / Q000138:chemical synthesis / Q000737:chemistry*; D010758:Phosphorus / Q000737:chemistry*; D013237:Stereoisomerism
D008024:Ligands; D010721:Phosphinic Acids; D010758:Phosphorus; D007495:Iridium; D009584:Nitrogen