Macrophage migration inhibitory factor: a probable link between inflammation and cancer.
The pleiotropic effects of macrophage migration inhibitory factor (MIF) place it in a central position in the immunopathogenesis of many diseases. Here we discuss the current understanding of MIF's role and highlight it as a potential link between inflammatory activation and malignant progression.
Bucala
Richard
R
Department of Medicine, Yale University School of Medicine, New Haven, CT 06520, USA. richard.bucala@yale.edu
Donnelly
Seamas C
SC
D000818:Animals; D006801:Humans; D000860:Hypoxia / Q000235:genetics / Q000276:immunology; D007113:Immunity, Innate; D007249:Inflammation / Q000235:genetics / Q000276:immunology*; D008263:Macrophage Migration-Inhibitory Factors / Q000037:antagonists & inhibitors / Q000235:genetics / Q000502:physiology*; D051379:Mice; D009369:Neoplasms / Q000235:genetics / Q000276:immunology*; D009389:Neovascularization, Pathologic / Q000235:genetics / Q000276:immunology; D011971:Receptors, Immunologic / Q000502:physiology; D018805:Sepsis / Q000235:genetics / Q000276:immunology; D016159:Tumor Suppressor Protein p53 / Q000502:physiology
D008263:Macrophage Migration-Inhibitory Factors; D011971:Receptors, Immunologic; D016159:Tumor Suppressor Protein p53; C033184:macrophage migration inhibitory factor receptor