Highly efficient ruthenium catalysts for the formation of tetrasubstituted olefins via ring-closing metathesis.
[reaction: see text] A series of ruthenium-based metathesis catalysts with N-heterocyclic carbene (NHC) ligands have been prepared in which the N-aryl groups have been changed from mesityl to mono-ortho-substituted phenyl (e.g., tolyl). These new catalysts offer an exceptional increase in activity for the formation of tetrasubstituted olefins via ring-closing metathesis (RCM), while maintaining high levels of activity in ring-closing metathesis (RCM) reactions that generate di- and trisubstituted olefins.
Stewart
Ian C
IC
The Arnold and Mabel Beckman Laboratory of Chemical Synthesis, Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA.
Ung
Thay
T
Pletnev
Alexandre A
AA
Berlin
Jacob M
JM
Grubbs
Robert H
RH
Schrodi
Yann
Y
D000475:Alkenes / Q000737:chemistry*; D002384:Catalysis; D008958:Models, Molecular; D015394:Molecular Structure; D012428:Ruthenium / Q000737:chemistry*
D000475:Alkenes; D012428:Ruthenium