title: Heightened seizure susceptibility associated with brain dermoid cyst and the administration of human chorionic gonadotropin (hCG).
abstract: It is known that the intramuscular injection of human chorionic gonadotropin (hCG) lowers the threshold for motor evoked responses (MEPs) in the first dorsal interosseous (FDI) muscle to transcranial magnetic stimulation (TMS) in humans. We describe the case of a patient with a clinically silent left-sided nasofrontal dermoid cyst who, while being treated with hCG/LH for hypogonadotropic hypogonadism, presented with simple partial seizures, ipsilateral to the cyst, with secondary generalization. Motor cortex excitability was studied by single and paired TMS and MEPs were recorded from FDI. Resting motor threshold (RMT), active motor threshold (AMT), MEP size, intracortical inhibition (ICI) and intracortical facilitation (ICF) were tested during and after suspension of hormonal therapy. RMT and AMT were lower, MEP size was larger, ICI was decreased while ICF was slightly diminished during treatment. Overall, this indicated a reduced intracortical inhibition during hormonal therapy. It is concluded that treatment with hCG/LH may favour seizure onset in the presence of potentially epileptogenic lesions such as an intracranial dermoid cyst.
authors: Section of Clinical Neurophysiology, Department of Neurological and Behavioral Sciences, University of Siena, Italy.
authors: Paolo
authors: P
authors: Milani
authors: Raffaele
authors: R
authors: Rocchi
authors: Alfonso
authors: A
authors: Cerase
authors: Alessandro
authors: A
authors: Rossi
authors: Riccardo
authors: R
authors: Mazzocchio
mesh_terms: D000328:Adult; D001921:Brain / Q000187:drug effects* / Q000473:pathology; D006063:Chorionic Gonadotropin / Q000009:adverse effects*; D003884:Dermoid Cyst / Q000188:drug therapy* / Q000473:pathology*; D004198:Disease Susceptibility / Q000139:chemically induced*; D004558:Electric Stimulation / Q000379:methods; D004569:Electroencephalography; D004576:Electromyography / Q000379:methods; D019054:Evoked Potentials, Motor / Q000187:drug effects / Q000502:physiology / Q000528:radiation effects; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D008297:Male; D012640:Seizures / Q000139:chemically induced*; D050781:Transcranial Magnetic Stimulation / Q000379:methods
chemical_list: D006063:Chorionic Gonadotropin