[The transmembranous passes of K+ in brain cortex under radiation and chemical influences and their modification with natural adaptogen].
An investigation of the influence of chronic low-intensity irradiation with 0.25 Gr dose and of a mixture of heavy metal salts both apart and together, as well as when correcting with a natural adaptogen such as Spirulina platensis, on passive and active transport of potassium and the work efficiency of Na,K-pump in slices of brain cortex was the problem of this study. As a biological model for in vivo researches on molecular-cellular level the thin layers of a rat brain cortex were used. It was shown that both radiation and chemical factors cause reliable changes of passive membrane permeability and operation of Na,K-pump, whose function is the maintenance of the certain gradient of potassium ions on the plasmatic membrane, the normalization of ion homeostasis, the stabilization of membranous potential. The analysis of calculated indexes of passive and of active ion transport show that at modification of X-rays influence with a mixture of heavy metal salts exactly the last makes the main contribution to efficiency decrease of energy-dependent transport of potassium. The natural adaptogen spirulina renders a better effect in the case of toxic action of the mixture of heavy metal salts, enlarging not only active transport of potassium ions, but its efficiency as well.
Severinovskaia
E V
EV
Zaĭchenko
E Iu
EIu
Dvoretskiĭ
A I
AI
D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects / Q000528:radiation effects; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D002463:Cell Membrane Permeability / Q000187:drug effects* / Q000528:radiation effects; D002540:Cerebral Cortex / Q000187:drug effects* / Q000528:radiation effects; D008297:Male; D019216:Metals, Heavy / Q000037:antagonists & inhibitors* / Q000633:toxicity; D028321:Plant Preparations / Q000494:pharmacology*; D011188:Potassium / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*; D053545:Spirulina / Q000737:chemistry*; D014965:X-Rays
D019216:Metals, Heavy; D028321:Plant Preparations; D000254:Sodium-Potassium-Exchanging ATPase; D011188:Potassium