title: Exceptional stereoselectivity in the synthesis of 1,3,4-trisubstituted 4-carboxy beta-lactam derivatives from amino acids.
abstract: [reaction: see text] The base-promoted cyclization of optically pure N-(p-methoxybenzyl)-N-(2-chloro)propionyl amino acid derivatives resulted in a diastereo- and enantioselective approach to valuable 1,3,4,4-tetrasubstituted beta-lactams. The stereochemical outcome of the reaction is exclusively governed by the configuration of the N-(2-chloro)propionyl moiety.
authors: Instituto de Química Médica (CSIC), Juan de la Cierva, 3, 28006 Madrid, Spain.
authors: Paula
authors: P
authors: Pérez-Faginas
authors: Fran
authors: F
authors: O'Reilly
authors: Aisling
authors: A
authors: O'Byrne
authors: Carlos
authors: C
authors: García-Aparicio
authors: Mercedes
authors: M
authors: Martín-Martínez
authors: M Jesús
authors: MJ
authors: Pérez de Vega
authors: M Teresa
authors: MT
authors: García-López
authors: Rosario
authors: R
authors: Gonzalez-Muñiz
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D004151:Dipeptides / Q000138:chemical synthesis / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D013237:Stereoisomerism; D047090:beta-Lactams / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D000596:Amino Acids; D004151:Dipeptides; D047090:beta-Lactams