Involvement of galanin in nociceptive regulation in the arcuate nucleus of hypothalamus in rats with mononeuropathy.
The hindpaw withdrawal latencies (HWLs) to noxious thermal and mechanical stimulation increased significantly after intra-hypothalamic arcuate nucleus (ARC) injection of galanin in mononeuropathic rats, while intra-ARC injection of the putative antagonist of galanin receptors markedly reduced the HWLs. The number of galaninergic neurons in the ARC increased in rats with mononeuropathy than that in normal rats. The results demonstrated that both endogenous and exogenous galanin were involved in the regulation of nociception in the ARC of rats with peripheral nerve injury.
Gu
Xing-Long
XL
Neurobiology Laboratory and National Laboratory of Biomembrane and Membrane Biotechnology, Center for Brain and Cognitive Science, College of Life Sciences, Peking University, Beijing 100871, People's Republic of China.
Sun
Yan-Gang
YG
Yu
Long-Chuan
LC
D000818:Animals; D001111:Arcuate Nucleus of Hypothalamus / Q000378:metabolism*; D019004:Galanin / Q000502:physiology*; D008297:Male; D020422:Mononeuropathies / Q000378:metabolism*; D017288:Pain Threshold / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time / Q000502:physiology*
D019004:Galanin