Uterine sarcomas.
A wide variety of sarcomas occur in the uterus but two subtypes - leiomyosarcoma and endometrial stromal sarcoma - account for a majority of those more routinely encountered. Using the 2003 World Health Organization classification, this review focuses on six uterine sarcomas: endometrial stromal sarcoma, undifferentiated endometrial sarcoma, leiomyosarcoma, rhabomyosarcoma, angiosarcoma and liposarcoma. The epidemiological, clinical, pathological and molecular features are presented along with therapeutic approaches. Familiarity with molecular aspects of these tumors and application of novel technologies in their assessment should be encouraged as they may provide alternate therapies resulting in improved survival for the patient. Clinical information necessary for accurate diagnosis of these lesions is emphasised. A multidisciplinary approach to management of patients with uterine sarcomas is essential for optimal management.
Moinfar
Farid
F
Department of Pathology, Graz University School of Medicine, Austria.
Azodi
Masood
M
Tavassoli
Fattaneh A
FA
D000970:Antineoplastic Agents / Q000627:therapeutic use; D005260:Female; D006801:Humans; D012509:Sarcoma / Q000175:diagnosis / Q000235:genetics / Q000628:therapy; D020845:Selective Estrogen Receptor Modulators / Q000009:adverse effects; D013629:Tamoxifen / Q000009:adverse effects; D014594:Uterine Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000628:therapy
D000970:Antineoplastic Agents; D020845:Selective Estrogen Receptor Modulators; D013629:Tamoxifen