title: Transfer of dexamphetamine into breast milk during treatment for attention deficit hyperactivity disorder.
abstract: OBJECTIVE
  To investigate dexamphetamine transfer into milk, infant doses and effects in the breast-fed infant.
  
  
  METHODS
  Four women taking dexamphetamine, and their infants were studied.
  
  
  RESULTS
  The median maternal dexamphetamine dose was 18 mg day(-1) (range 15-45 mg day(-1)). Median (interquartile range) descriptors were 3.3 (2.2-4.8) for milk/plasma ratio, 21 microg kg(-1) day(-1) (11-39) for absolute infant dose and 5.7% (4-10.6%) for relative infant dose. No adverse effects were seen. In three infants tested, dexamphetamine in plasma was undetected in one (limit of detection 1 microg l(-1)) and present at 18 microg l(-1) and 2 microg l(-1) in the other two.
  
  
  CONCLUSIONS
  Dexamphetamine readily transfers into milk. The relative infant dose was <10% and within a range that is generally accepted as being 'safe' in the short term.
authors: Pharmacology Unit M510, School of Medicine and Pharmacology, University of Western Australia, 35 Stirling Hwy, Crawley, 6009 Australia. ken.ilett@uwa.edu.au
authors: Kenneth F
authors: KF
authors: Ilett
authors: L Peter
authors: LP
authors: Hackett
authors: Judith H
authors: JH
authors: Kristensen
authors: Rolland
authors: R
authors: Kohan
mesh_terms: D000328:Adult; D001289:Attention Deficit Disorder with Hyperactivity / Q000188:drug therapy*; D001942:Breast Feeding; D003913:Dextroamphetamine / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008895:Milk, Human / Q000737:chemistry*; D011247:Pregnancy
chemical_list: D003913:Dextroamphetamine