title: The effect of oxytocin and PGF2alpha on the uterine involution and pregnancy rates in postpartum Arabian mares.
abstract: In this study, the effects of oxytocin and an analog of prostaglandin (cloprostenol) on the uterine involution and pregnancy rates were investigated. Mares received 3 ml of 0.9% NaCl in Group C (n=10), 30 IU/mare of oxytocin in Group O (n=10) and 250 microg/mare of cloprostenol in Group P (n=10) within 12h after parturition. The gravid uterine horn's cross-sectional diameter was measured by ultrasonography. The mean uterine diameters did not differ significantly between the treatment (O and P) and the control (C) groups (p>0.05). The difference between the postpartum ovulation periods (Group C: 12.6+/-0.72 days, Group O: 15+/-1.33 days, Group P: 14.6+/-1.11 days), the pregnancy rates at foal heat (Group C: 60%, Group O: 60%, Group P: 80%) and the embryonic death rates at foal heat (Group C: 33.3%, Group O: 16%, Group P: 25%) were not found to be statistically significant between the treatment and the control groups. The mean progesterone concentrations were similar in all groups and decreased continuously from parturition to until foal heat (Group C: from 2.43+/-0.24 to 0.66 ng/ml, Group O: from 3.07+/-0.6 to 0.27+/-0.27 ng/ml and Group P: from 2.8+/-0.44 to 0 ng/ml) (p>0.05). In conclusion, it was decided that the oxytocin and PGF2alpha treatments performed on the mares with the purpose of stimulating involution had no effect on the duration of parturition-first ovulation, the shrinkage of the uterus diameter, the pregnancy and embryonic death rates.
authors: Department of Obstetrics and Gynecology, Faculty of Veterinary Medicine, University of Istanbul, Avcilar 34320, Istanbul, Turkey. mcg@istanbul.edu.tr
authors: Mehmet Can
authors: MC
authors: Gündüz
authors: Güven
authors: G
authors: Kaşikçi
authors: Huriye H
authors: HH
authors: Kaya
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D005260:Female; D005313:Fetal Death; D006736:Horses / Q000502:physiology*; D008297:Male; D010060:Ovulation / Q000187:drug effects* / Q000502:physiology; D010121:Oxytocin / Q000494:pharmacology*; D049590:Postpartum Period; D011247:Pregnancy; D011374:Progesterone / Q000097:blood; D011897:Random Allocation; D014463:Ultrasonography; D014599:Uterus / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000502:physiology
chemical_list: D011374:Progesterone; D010121:Oxytocin