Hyrtinadine A, a bis-indole alkaloid from a marine sponge.
A new cytotoxic bis-indole alkaloid, hyrtinadine A (1), with a pyrimidine moiety has been isolated from an Okinawan marine sponge Hyrtios sp., and the structure was elucidated on the basis of spectroscopic data.
Endo
Taeko
T
Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.
Tsuda
Masashi
M
Fromont
Jane
J
Kobayashi
Jun'ichi
J
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D007624:KB Cells; D008386:Marine Biology; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry*
D000970:Antineoplastic Agents; D026121:Indole Alkaloids; C519139:hyrtinadine A