title: Practical method for the absolute configuration assignment of tert/tert 1,2-diols using their complexes with Mo2(OAc)4.
abstract: We describe here an application of the practical, simple, and reliable approach for the determination of the absolute configuration of sterically demanding tert/tert vic-diols. According to this method, it is only necessary to mix dimolybdenum tetraacteate and a chiral diol in DMSO and record the CD spectra in the 250-650 nm spectral range. From the sign of the CD bands occurring at around 310, 350, and 400 nm, it is possible to establish the chirality of the diol unit expressed by the sign of the O-C-C-O torsion angle. Because the preferred conformation of the diol in the formed complex is known, we are able to determine the absolute configuration of the carbon atoms in the diol subunit even in flexible tert/tert vic-diols.
authors: Institute of Organic Chemistry of the Polish Academy of Sciences, Kasprzaka 44, 01-224 Warsaw, Poland.
authors: Marcin
authors: M
authors: Górecki
authors: Ewa
authors: E
authors: Jabłońska
authors: Anna
authors: A
authors: Kruszewska
authors: Agata
authors: A
authors: Suszczyńska
authors: Zofia
authors: Z
authors: Urbańczyk-Lipkowska
authors: Michael
authors: M
authors: Gerards
authors: Jacek W
authors: JW
authors: Morzycki
authors: Wojciech J
authors: WJ
authors: Szczepek
authors: Jadwiga
authors: J
authors: Frelek
mesh_terms: D006018:Glycols / Q000737:chemistry*; D015394:Molecular Structure; D008982:Molybdenum; D009942:Organometallic Compounds; D013237:Stereoisomerism
chemical_list: D006018:Glycols; D009942:Organometallic Compounds; C437387:dimolybdenum tetraacetate; D008982:Molybdenum