title: Highly efficient ruthenium catalysts for the formation of tetrasubstituted olefins via ring-closing metathesis.
abstract: [reaction: see text] A series of ruthenium-based metathesis catalysts with N-heterocyclic carbene (NHC) ligands have been prepared in which the N-aryl groups have been changed from mesityl to mono-ortho-substituted phenyl (e.g., tolyl). These new catalysts offer an exceptional increase in activity for the formation of tetrasubstituted olefins via ring-closing metathesis (RCM), while maintaining high levels of activity in ring-closing metathesis (RCM) reactions that generate di- and trisubstituted olefins.
authors: The Arnold and Mabel Beckman Laboratory of Chemical Synthesis, Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA.
authors: Ian C
authors: IC
authors: Stewart
authors: Thay
authors: T
authors: Ung
authors: Alexandre A
authors: AA
authors: Pletnev
authors: Jacob M
authors: JM
authors: Berlin
authors: Robert H
authors: RH
authors: Grubbs
authors: Yann
authors: Y
authors: Schrodi
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D002384:Catalysis; D008958:Models, Molecular; D015394:Molecular Structure; D012428:Ruthenium / Q000737:chemistry*
chemical_list: D000475:Alkenes; D012428:Ruthenium