title: A web tool for the identification of potential interactive effects of chemical mixtures.
abstract: This project was undertaken to develop a toxicological database allowing the identification of possible additive or other interactive effects of mixtures present in the work environment. In the first phase of the project, whose findings have already been published, critical toxicological data were compiled for each of the 695 chemical substances in the Quebec Occupational Health Regulation, allowing the prediction of potential additivity among components of a mixture. In the second phase of this project, the types of interactions for mixtures most likely to be found in workplaces and for which primary literature data are available were specified. The toxicological data were evaluated only for realistic exposure concentrations up to the short-term exposure limit or ceiling value or five times the 8-hr time-weighted average (TWA) permissible exposure limit (PEL) for human data and up to 100 times the 8-hr TWA PEL or ceiling value for animal studies. In total, 675 studies were evaluated covering 209 binary mixtures of substances. For the majority of cases where potential additivity was identified in Phase 1, there is a lack of toxicological data in the primary literature. In these cases, the results of the first phase will be useful as the default hypothesis. The resulting database integrates the results from both phases of the project. A web-based computer tool allows the user to determine whether there is potential additivity or interaction among components of a mixture.
authors: Groupe de Recherche Interdisciplinaire en Santé, Département de Santé Environnementale et Santé au Travail, University of Montreal, Montreal, Canada. adolf.vyskocil@umontreal.ca
authors: Adolf
authors: A
authors: Vyskocil
authors: Daniel
authors: D
authors: Drolet
authors: Claude
authors: C
authors: Viau
authors: Francois
authors: F
authors: Lemay
authors: Gilles
authors: G
authors: Lapointe
authors: Robert
authors: R
authors: Tardif
authors: Ginette
authors: G
authors: Truchon
authors: Marc
authors: M
authors: Baril
authors: Normand
authors: N
authors: Gagnon
authors: France
authors: F
authors: Gagnon
authors: Denis
authors: D
authors: Bégin
authors: Michel
authors: M
authors: Gérin
mesh_terms: D000395:Air Pollutants, Occupational / Q000633:toxicity*; D000818:Animals; D045424:Complex Mixtures / Q000633:toxicity*; D016208:Databases, Factual / Q000706:statistics & numerical data*; D004282:Documentation; D004357:Drug Synergism; D006801:Humans; D020407:Internet; D016273:Occupational Exposure / Q000009:adverse effects*
chemical_list: D000395:Air Pollutants, Occupational; D045424:Complex Mixtures