title: Risk of gastrointestinal cancer in patients with unexplained chest/epigastric pain and normal upper endoscopy: a Danish 10-year follow-up study.
abstract: Unexplained chest/epigastric pain is a common symptom in the general population. However, it has not previously been studied whether such pain could be a marker of subsequent gastrointestinal cancer. We aimed to estimate the risk of gastrointestinal cancers in a Danish 10-year follow-up study among patients with chest/epigastric pain, normal upper endoscopy, and no prior discharge diagnosis of ischemic heart disease (N = 386), compared with population controls (N = 3860). The overall 10-year risk of gastrointestinal cancer (stomach, colorectal, liver, and pancreas) was 2.9% for patients with unexplained chest/epigastric pain vs. 1.5% for controls. The adjusted relative risks <1 year and > or =1 year after upper endoscopy were 8.4 (95% confidence interval [CI], 2.6-27.5) and 1.2 (95% CI, 0.5-2.9), respectively. We found that patients with unexplained chest/epigastric pain have an increased risk of gastrointestinal cancer within the first year after upper endoscopy. Consequently, unexplained chest/epigastric pain might be an early gastrointestinal cancer symptom.
authors: Department of Clinical Epidemiology, Aarhus and Aalborg Hospital, Aarhus University Hospital, DK-8000, Aarhus, Denmark. emm@dce.au.dk
authors: Estrid Muff
authors: EM
authors: Munk
authors: Asbjørn Mohr
authors: AM
authors: Drewes
authors: Anders
authors: A
authors: Gorst-Rasmussen
authors: Peter
authors: P
authors: Funch-Jensen
authors: Hans
authors: H
authors: Gregersen
authors: Bente
authors: B
authors: Nørgård
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002637:Chest Pain / Q000150:complications*; D003718:Denmark / Q000453:epidemiology; D016145:Endoscopy, Digestive System; D005260:Female; D005500:Follow-Up Studies; D005770:Gastrointestinal Neoplasms / Q000453:epidemiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors