title: Prevalence of migraine in Noonan syndrome.
abstract: A randomized double-controlled trial involving 22 patients with Noonan syndrome (NS) and 22 normal individuals (control group) was carried out to determine the prevalence of migraine in patients with NS. The NS group consisted of 11 males aged 19.55 +/- 6.11 years and 11 females aged 18.81 +/- 5.47 years. The control group consisted of 11 males aged 19.55 +/- 6.6 years and 11 females aged 18.81 +/- 5.47 years. Seven NS-group patients reported migraine without aura (MO), and three reported probable MO (PMO). Taken together, these represent a prevalence of migraine in the NS group of 45.5%. Two control-group patients reported MO, a prevalence of 9.09%. The prevalence of migraine was significantly higher in the NS-group patients than in the controls (P < 0.005), suggesting a positive association between NS and migraine. Nevertheless, further studies are needed to confirm our findings.
authors: Headache Unit, Neurology Division, Internal Medicine Department, Hospital de Clínicas, Universidade Federal do Paraná, Curitiba, Brazil. piovesan@avalon.sul.com.br
authors: E J
authors: EJ
authors: Piovesan
authors: M R
authors: MR
authors: Young Blood
authors: P A
authors: PA
authors: Kowacs
authors: R A
authors: RA
authors: Mulinari
authors: L C
authors: LC
authors: Werneck
authors: R
authors: R
authors: Sandrini
mesh_terms: D000293:Adolescent; D000328:Adult; D001938:Brazil / Q000453:epidemiology; D002648:Child; D015897:Comorbidity; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008881:Migraine Disorders / Q000175:diagnosis* / Q000453:epidemiology*; D009634:Noonan Syndrome / Q000175:diagnosis* / Q000453:epidemiology*; D015995:Prevalence; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors