title: [Neurotropic effects cytokines and trophic factors].
abstract: Cytokines and trophic factors (TF) are involved into the nervous system activity regulation that confirms by their secretion and receptors identification within nervous system. Cytokines and TF production increases tremendously in response to CNS alterations or other CNS pathologic events where they are modulated both alterative and protective effects. Authors observed the data of clinical and laboratory investigations concerning the cytokines and TF-neurotropic effects and also the original results dedicated to investigation of tumor necrosis factor-alpha and interleukin-1-beta influence on experimental seizure syndrome. The new data about cytokines and TF-neurotropic effects as well as their influence on the experimental seizure syndrome are reviewed. The clinical use of cytokines and TF-perspective is evaluated also.
authors: R S
authors: RS
authors: Vast'ianov
authors: A A
authors: AA
authors: Oleĭnik
mesh_terms: D000818:Animals; D002490:Central Nervous System / Q000187:drug effects / Q000502:physiology* / Q000503:physiopathology; D016207:Cytokines / Q000502:physiology* / Q000627:therapeutic use / Q000633:toxicity; D053583:Interleukin-1beta / Q000502:physiology* / Q000627:therapeutic use / Q000633:toxicity; D012640:Seizures / Q000188:drug therapy / Q000209:etiology*; D013577:Syndrome; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology* / Q000627:therapeutic use / Q000633:toxicity
chemical_list: D016207:Cytokines; D053583:Interleukin-1beta; D014409:Tumor Necrosis Factor-alpha