Neuroleptic malignant syndrome induced by ziprasidone on the second day of treatment.
Neuroleptic malignant syndrome (NMS) is the rarest and most serious of the neuroleptic-induced movement disorders. We describe a case of neuroleptic malignant syndrome (NMS) associated with the use of ziprasidone. Although conventional neuroleptics are more frequently associated with NMS, atypical antipsychotic drugs like ziprasidone may also be a cause. The patient is a 24-year-old male with a history of schizophrenia who developed signs and symptoms of NMS after 2 days of treatment with an 80-mg/day dose of orally administrated ziprasidone. This case is the earliest (second day of treatment) NMS due to ziprasidone reported in the literature.
Ozen
Murat Eren
ME
Department of Psychiatry, Gaziantep University Faculty of Medicine, Gaziantep, Turkey.
Yumru
Mehmet
M
Savas
Haluk A
HA
Cansel
Neslihan
N
Herken
Hasan
H
D000328:Adult; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001712:Biperiden / Q000008:administration & dosage; D003937:Diagnosis, Differential; D003975:Diazepam / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D009459:Neuroleptic Malignant Syndrome / Q000188:drug therapy / Q000209:etiology*; D009460:Neurologic Examination / Q000187:drug effects; D020734:Parkinsonian Disorders / Q000139:chemically induced / Q000175:diagnosis / Q000188:drug therapy; D010879:Piperazines / Q000008:administration & dosage / Q000009:adverse effects*; D012559:Schizophrenia / Q000175:diagnosis / Q000188:drug therapy*; D013844:Thiazoles / Q000008:administration & dosage / Q000009:adverse effects*
D014150:Antipsychotic Agents; D010879:Piperazines; D013844:Thiazoles; D001712:Biperiden; C092292:ziprasidone; D003975:Diazepam