title: Piperazinyl CCR1 antagonists--optimization of human liver microsome stability.
abstract: The synthesis, biological activity, and pharmacokinetic profile of CCR1 antagonists are described.
authors: Pfizer Global Research and Development, Eastern Point Road, Groton, CT 06340, USA. matthew.f.brown@pfizer.com
authors: Matthew F
authors: MF
authors: Brown
authors: Kevin B
authors: KB
authors: Bahnck
authors: Laura C
authors: LC
authors: Blumberg
authors: William H
authors: WH
authors: Brissette
authors: Sara A
authors: SA
authors: Burrell
authors: James P
authors: JP
authors: Driscoll
authors: Flavia
authors: F
authors: Fedeles
authors: Michael B
authors: MB
authors: Fisher
authors: Robert S
authors: RS
authors: Foti
authors: Ronald P
authors: RP
authors: Gladue
authors: Aikomari
authors: A
authors: Guzman-Martinez
authors: Matthew M
authors: MM
authors: Hayward
authors: Paul D
authors: PD
authors: Lira
authors: Brett M
authors: BM
authors: Lillie
authors: Yi
authors: Y
authors: Lu
authors: Greg D
authors: GD
authors: Lundquist
authors: Eric B
authors: EB
authors: McElroy
authors: Molly A
authors: MA
authors: McGlynn
authors: Timothy J
authors: TJ
authors: Paradis
authors: Christopher S
authors: CS
authors: Poss
authors: James H
authors: JH
authors: Roache
authors: Andrei
authors: A
authors: Shavnya
authors: Richard M
authors: RM
authors: Shepard
authors: Kristen A
authors: KA
authors: Trevena
authors: Laurie A
authors: LA
authors: Tylaska
mesh_terms: D000818:Animals; D004285:Dogs; D000882:Haplorhini; D006801:Humans; D008862:Microsomes, Liver / Q000378:metabolism; D010879:Piperazines / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism*; D051381:Rats; D054389:Receptors, CCR1; D019707:Receptors, Chemokine / Q000037:antagonists & inhibitors*
chemical_list: C515300:CCR1 protein, human; C515302:Ccr1 protein, rat; D010879:Piperazines; D054389:Receptors, CCR1; D019707:Receptors, Chemokine