Effects of warfarin on blood pressure in men with diabetes and hypertension--a longitudinal study.
Warfarin causes extensive vascular calcification leading to increased systolic blood pressure and pulse pressure in rats, may be associated with increased valvular and coronary calcifications in man, and possibly worsens hypertension in high-risk patients, particularly in those with diabetes mellitus or uncontrolled hypertension. The authors evaluated blood pressure and intensity of antihypertensive therapy over 36 months in a cohort of 58 patients with diabetes and hypertension on warfarin and 58 control subjects with diabetes and hypertension not on warfarin. The results demonstrate that warfarin therapy at conventional doses does not increase systolic blood pressure or pulse pressure in patients with diabetes and hypertension.
Lim
Mary Ann
MA
Department of Medicine, University of Connecticut School of Medicine, Farmington, CT, USA.
Shafique
Shahzad
S
See
Sein Yin
SY
Khan
Faisal N
FN
Parikh
Chirag R
CR
Peixoto
Aldo J
AJ
D000368:Aged; D000369:Aged, 80 and over; D000925:Anticoagulants / Q000009:adverse effects*; D000959:Antihypertensive Agents / Q000008:administration & dosage*; D001794:Blood Pressure / Q000187:drug effects*; D018849:Controlled Clinical Trials as Topic; D003920:Diabetes Mellitus / Q000503:physiopathology*; D004305:Dose-Response Relationship, Drug; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000503:physiopathology*; D008137:Longitudinal Studies; D008297:Male; D012044:Regression Analysis; D012107:Research Design; D016896:Treatment Outcome; D014859:Warfarin / Q000009:adverse effects*
D000925:Anticoagulants; D000959:Antihypertensive Agents; D014859:Warfarin