Targeting the Wnt/beta-catenin pathway to regulate bone formation in the adult skeleton.
The recent identification of a link between bone mass in humans and gain- or loss-of-function mutations in the Wnt coreceptor low-density lipoprotein receptor-related protein 5 (osteoporosis pseudoglioma syndrome, high bone mass trait) or in the Wnt antagonist sclerostin (sclerosteosis, van Buchem syndrome) has called the attention of academic and industry scientists and clinicians to the importance of this signaling pathway in skeletal biology and disease. Multiple genetic and pharmacological manipulations of Wnt signaling in mice have since then confirmed the central role of this pathway in regulating bone formation.
Baron
Roland
R
Yale University School of Medicine, 333 Cedar Street, P.O. Box 208044, New Haven, CT 06520-8044, USA. roland.baron@yale.edu
Rawadi
Georges
G
D048868:Adaptor Proteins, Signal Transducing; D000328:Adult; D000818:Animals; D050071:Bone Density Conservation Agents / Q000138:chemical synthesis / Q000627:therapeutic use; D001847:Bone Diseases / Q000188:drug therapy / Q000235:genetics; D019485:Bone Morphogenetic Proteins / Q000502:physiology; D001842:Bone and Bones / Q000378:metabolism / Q000502:physiology*; D015195:Drug Design; D005819:Genetic Markers / Q000502:physiology; D038362:Glycogen Synthase Kinase 3 / Q000502:physiology; D000071679:Glycogen Synthase Kinase 3 beta; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000502:physiology; D026502:LDL-Receptor Related Proteins / Q000737:chemistry / Q000378:metabolism / Q000502:physiology; D060492:Low Density Lipoprotein Receptor-Related Protein-5; D060488:Low Density Lipoprotein Receptor-Related Protein-6; D008954:Models, Biological; D010012:Osteogenesis / Q000235:genetics*; D011973:Receptors, LDL / Q000737:chemistry / Q000378:metabolism / Q000502:physiology; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology; D051153:Wnt Proteins / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D051176:beta Catenin / Q000235:genetics / Q000502:physiology*
D048868:Adaptor Proteins, Signal Transducing; D050071:Bone Density Conservation Agents; D019485:Bone Morphogenetic Proteins; C501126:DKK1 protein, human; D005819:Genetic Markers; D036341:Intercellular Signaling Peptides and Proteins; D026502:LDL-Receptor Related Proteins; C555482:LRP5 protein, human; C555475:LRP6 protein, human; D060492:Low Density Lipoprotein Receptor-Related Protein-5; D060488:Low Density Lipoprotein Receptor-Related Protein-6; C555483:Lrp5 protein, mouse; C555476:Lrp6 protein, mouse; D011973:Receptors, LDL; C422903:SOST protein, human; D051153:Wnt Proteins; D051176:beta Catenin; D000071679:Glycogen Synthase Kinase 3 beta; D038362:Glycogen Synthase Kinase 3