title: Functioning of patients with chronic idiopathic axonal polyneuropathy (CIAP).
abstract: Although patients with Chronic Idiopathic Axonal Polyneuropathy (CIAP) report a slow deterioration of sensory and motor functions, the impact of this deterioration on daily functioning has not yet been investigated in detail. The first aim of this cross-sectional study involving 56 patients with CIAP was, therefore, to assess patients' functioning with use of the International Classification of Functioning, Disability and Health (ICF). The second aim was to find determinants of walking ability, dexterity, and autonomy. Fatigue and limited walking ability were present in most patients and differed considerably. In regression models, age, muscle strength, and fatigue together explained 63% of the variance in walking ability, which by itself explained almost 50% of the variance in patients' autonomy indoors and outdoors (42% and 49%, respectively). Muscle strength and sensory function scores together explained 30% of the variance in dexterity scores, which in turn explained only 13% of the variance in autonomy indoors. The diminished autonomy of patients with CIAP might be improved by reducing fatigue, by means of training, and by improving walking ability.
authors: Rudolf Magnus Institute of Neuroscience, Dept. of Neurology and Neurosurgery, University Medical Center Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands. perdmann@umcutrecht.nl
authors: Peter G
authors: PG
authors: Erdmann
authors: Laurien L
authors: LL
authors: Teunissen
authors: Frank R
authors: FR
authors: van Genderen
authors: Nicolette C
authors: NC
authors: Notermans
authors: Eline
authors: E
authors: Lindeman
authors: Paul J M
authors: PJ
authors: Helders
authors: Nico L U
authors: NL
authors: van Meeteren
mesh_terms: D000368:Aged; D001369:Axons; D002908:Chronic Disease; D015897:Comorbidity; D003430:Cross-Sectional Studies; D003943:Diagnostic Techniques, Neurological; D005221:Fatigue / Q000175:diagnosis / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D019957:Motor Skills Disorders / Q000175:diagnosis / Q000453:epidemiology; D009119:Muscle Contraction; D018908:Muscle Weakness / Q000175:diagnosis / Q000453:epidemiology; D009426:Netherlands / Q000453:epidemiology; D011115:Polyneuropathies / Q000175:diagnosis* / Q000453:epidemiology / Q000503:physiopathology*; D016138:Walking