Grb2-associated binder 1 (Gab1) adaptor/scaffolding protein regulates Erk signal in human B cells.
RNA silencing experiments showed that knocking down Gab1 adaptor protein in BL41 human Burkitt lymphoma cells significantly reduced B cell receptor (BCR)-induced Erk phosphorylation, indicating that Gab1 plays a pivotal role in regulating Erk activity in B cells.
Angyal
Adrienn
A
Department of Immunology, Eotvos Lorand University, Pazmany Peter Setany 1/c, 1117 Budapest, Hungary.
Medgyesi
David
D
Sarmay
Gabriella
G
D048868:Adaptor Proteins, Signal Transducing / Q000502:physiology*; D001402:B-Lymphocytes / Q000201:enzymology* / Q000378:metabolism; D045744:Cell Line, Tumor; D048049:Extracellular Signal-Regulated MAP Kinases / Q000378:metabolism*; D006801:Humans; D010766:Phosphorylation; D015398:Signal Transduction
D048868:Adaptor Proteins, Signal Transducing; C098587:GAB1 protein, human; D048049:Extracellular Signal-Regulated MAP Kinases