Effect of various E. coli LPS chemotypes on apoptosis and activation of human neutrophils.
We studied the effects of various Escherichia coli LPS chemotypes on the production of reactive oxygen species and regulation of apoptosis in human neutrophils. A correlation was found between the increase in chemiluminescence (Re-LPS<Ra-LPS<S-LPS) and lengthening of the polysaccharide chain in endotoxins. Shortening of the polysaccharide chain was associated with more pronounced inhibition of neutrophil apoptosis under the influence of endotoxins, which correlated with the increase in hydrophobicity of these chemotypes.
Vinokurov
M G
MG
I. M. Sechenov Moscow Medical Academy. mgvinokurov@rambler.ru
Yurinskaya
M M
MM
Prokhorenko
I R
IR
Grachev
S V
SV
D017209:Apoptosis / Q000187:drug effects*; D004926:Escherichia coli / Q000737:chemistry*; D005434:Flow Cytometry; D006801:Humans; D008070:Lipopolysaccharides / Q000633:toxicity*; D008163:Luminescent Measurements; D018375:Neutrophil Activation / Q000187:drug effects*; D017382:Reactive Oxygen Species / Q000378:metabolism
D008070:Lipopolysaccharides; D017382:Reactive Oxygen Species