Isolation and structural determination of sorbinols A and B, new triterpenes from Sorbus cashmariana, by 1D and 2D NMR spectroscopy.
Two new pentacyclic triterpenes, sorbinols A (1) and B (2) have been isolated from the ethyl acetate fraction of Sorbus cashmariana and their structures assigned from (1)H and (13)C NMR spectra, DEPT and by 2D COSY, NOE, HMQC and HMBC experiments. Both 1 and 2 showed moderate inhibitory potential against the enzyme lipoxygenase.
Kazmi
Mehdi Hassan
MH
Department of Applied Chemistry, University of Karachi, Karachi-75270, Pakistan.
Ahmed
Ejaz
E
Hameed
Saira
S
Malik
Abdul
A
Ashraf
Muhammad
M
D004791:Enzyme Inhibitors / Q000737:chemistry; D008084:Lipoxygenase / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry; D031994:Sorbus / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry*
D004791:Enzyme Inhibitors; D010936:Plant Extracts; D014315:Triterpenes; C521456:sorbinol A; C521457:sorbinol B; D008084:Lipoxygenase