title: Localized biosensing with Topas microstructured polymer optical fiber.
abstract: We present what is believed to be the first microstructured polymer optical fiber (mPOF) fabricated from Topas cyclic olefin copolymer, which has attractive material and biochemical properties. This polymer allows for a novel type of fiber-optic biosensor, where localized sensor layers may be activated on the inner side of the air holes in a predetermined section of the mPOF. The concept is demonstrated using a fluorescence-based method for selective detection of fluorophore-labeled antibodies.
authors: COM - DTU, Department of Communications, Optics and Materials, Technical University of Denmark, Muilding 345v, 2800 Kgs. Lyngby, Denmark. gem@com.dtu.dk
authors: Grigoriy
authors: G
authors: Emiliyanov
authors: Jesper B
authors: JB
authors: Jensen
authors: Ole
authors: O
authors: Bang
authors: Poul E
authors: PE
authors: Hoiby
authors: Lars H
authors: LH
authors: Pedersen
authors: Erik M
authors: EM
authors: Kjaer
authors: Lars
authors: L
authors: Lindvold
mesh_terms: D000475:Alkenes / Q000737:chemistry; D001672:Biocompatible Materials / Q000737:chemistry; D015374:Biosensing Techniques; D002097:C-Reactive Protein / Q000737:chemistry; D002232:Carbocyanines / Q000737:chemistry; D005336:Fiber Optic Technology; D008856:Microscopy, Fluorescence / Q000295:instrumentation / Q000379:methods; D055100:Optical Fibers; D055095:Optics and Photonics; D011108:Polymers / Q000737:chemistry*; D019904:Polymethyl Methacrylate / Q000737:chemistry; D019809:Streptavidin / Q000737:chemistry; D014466:Ultraviolet Rays
chemical_list: D000475:Alkenes; D001672:Biocompatible Materials; D002232:Carbocyanines; D011108:Polymers; C089187:cyanine dye 3; D002097:C-Reactive Protein; D019904:Polymethyl Methacrylate; D019809:Streptavidin