title: Assessment of simple movements and progression of Huntington's disease.
abstract: Instrumental measurement of simple motion sequences reflects impairment in patients with Huntington's disease (HD). The objectives were to study the progress of symptoms of HD and tapping results in 42 patients with HD, without symptomatic drug treatment over 3 years. Assessment moments were at baseline, and at years 1, 2 and 3. Unified Huntington's Disease Rating Scale (UHDRS) total score and UHDRS arm score significantly increased. Motor test outcomes considerably worsened. Instrumental test results significantly correlated with both UHDRS scores at each assessment. Assessment of simple movement sequences is an additional simple method to follow impairment in patients with HD in addition to clinical rating.
authors: Department of Neurology, St Josef Hospital, Ruhr University Bochum, Gudrunstrasse 56, D-44791 Bochum, Germany.
authors: Jürgen
authors: J
authors: Andrich
authors: Carsten
authors: C
authors: Saft
authors: Natalie
authors: N
authors: Ostholt
authors: Thomas
authors: T
authors: Müller
mesh_terms: D018450:Disease Progression; D005260:Female; D006801:Humans; D006816:Huntington Disease / Q000150:complications* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D019957:Motor Skills Disorders / Q000145:classification / Q000209:etiology*; D011446:Prospective Studies; D012016:Reference Values