The PI3K p110delta controls T-cell development, differentiation and regulation.
PI3Ks (phosphoinositide 3-kinases) regulate diverse cellular functions such as metabolism, growth, gene expression and migration. The p110delta isoform of PI3K is mainly expressed in cells of the immune system and contributes to cellular and humoral immunity. In the thymus, p110delta and p110gamma play complementary roles in regulating the transition through key developmental checkpoints. In addition, p110delta regulates the differentiation of peripheral Th (helper T-cells) towards the Th1 and Th2 lineages. Moreover, p110delta is critical for Treg (regulatory T-cell) function. Here, we review the role of PI3Ks in T-cell development and function.
Patton
D T
DT
Laboratory of Lymphocyte Signalling and Development, The Babraham Institute, Cambridge, UK.
Garçon
F
F
Okkenhaug
K
K
D015703:Antigens, CD / Q000276:immunology; D002454:Cell Differentiation; D058544:Class Ib Phosphatidylinositol 3-Kinase; D051858:Forkhead Transcription Factors / Q000276:immunology; D006801:Humans; D007107:Immune System / Q000201:enzymology; D007527:Isoenzymes / Q000276:immunology / Q000378:metabolism; D019869:Phosphatidylinositol 3-Kinases / Q000276:immunology / Q000378:metabolism*; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000201:enzymology / Q000276:immunology; D018417:Th1 Cells / Q000201:enzymology / Q000276:immunology; D018418:Th2 Cells / Q000201:enzymology / Q000276:immunology; D013950:Thymus Gland / Q000276:immunology
D015703:Antigens, CD; D051858:Forkhead Transcription Factors; D007527:Isoenzymes; D019869:Phosphatidylinositol 3-Kinases; D058544:Class Ib Phosphatidylinositol 3-Kinase; C546760:PIK3CG protein, human