title: Follicular dendritic cell sarcoma of the spleen.
abstract: Diagnosis of primary spindle cell tumors of the spleen is challenging because of the limited immunologic and cytogenetic characterization of this rare entity. We report a case of primary follicular dendritic cell (FDC) sarcoma of the spleen in a 44-year-old woman. Indications for FDC included positive staining for CD21, Ki-M4P, CD14, and fascin. Expression of both standard FDC markers CD23 and CD35 was detected immunohistochemically using tyramide signal amplification. Cytogenetic analysis revealed multiple clonal chromosomal aberrations involving unbalanced translocations of chromosomes X, 3, 5, 7, 8, 9, and 10, leading to net gains at 3q, 7p, 8q, and 9q and net losses at Xp, 8p, 9p, and 10p. Loss at Xp has been described previously in another tumor with FDC features, suggesting that this aberration might play a common role in this malignancy.
authors: Department of Pathology, University of Göttingen, 37099 Göttingen, Germany.
authors: Bjoern
authors: B
authors: Sander
authors: Peter
authors: P
authors: Middel
authors: Bastian
authors: B
authors: Gunawan
authors: Hans-Jürgen
authors: HJ
authors: Schulten
authors: Friedeman
authors: F
authors: Baum
authors: Mariola Monika
authors: MM
authors: Golas
authors: Frank
authors: F
authors: Schulze
authors: Eckhardt
authors: E
authors: Grabbe
authors: Reza
authors: R
authors: Parwaresch
authors: László
authors: L
authors: Füzesi
mesh_terms: D000328:Adult; D002869:Chromosome Aberrations; D002879:Chromosomes, Human, Pair 10 / Q000235:genetics; D002893:Chromosomes, Human, Pair 3 / Q000235:genetics; D002895:Chromosomes, Human, Pair 5 / Q000235:genetics; D002897:Chromosomes, Human, Pair 7 / Q000235:genetics; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics; D041321:Chromosomes, Human, X / Q000235:genetics; D020566:Dendritic Cells, Follicular / Q000473:pathology; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D017463:Receptors, Complement 3b / Q000032:analysis; D017455:Receptors, IgE / Q000032:analysis; D012509:Sarcoma / Q000235:genetics / Q000473:pathology*; D013160:Splenic Neoplasms / Q000235:genetics / Q000473:pathology*; D014178:Translocation, Genetic
chemical_list: D017463:Receptors, Complement 3b; D017455:Receptors, IgE