Distal charge transport in peptides.
Biological systems often transport charges and reactive processes over substantial distances. Traditional models of chemical kinetics generally do not describe such extreme distal processes. In this Review, an atomistic model for a distal transport of information, which was specifically developed for peptides, is considered. Chemical reactivity is taken as the result of distal effects based on two-step bifunctional kinetics involving unique, very rapid motional properties of peptides in the subpicosecond regime. The bifunctional model suggests highly efficient transport of charge and reactivity in an isolated peptide over a substantial distance; conversely, a very low efficiency in a water environment was found. The model suggests ultrafast transport of charge and reactivity over substantial molecular distances in a peptide environment. Many such domains can be active in a protein.
Schlag
Edward W
EW
Institut für Physikalische und Theoretische Chemie, Technische Universität München, Lichtenbergstrasse 4, 85748 Garching, Germany. schlag@mytum.de
Sheu
Sheh-Yi
SY
Yang
Dah-Yen
DY
Selzle
Heinrich L
HL
Lin
Sheng Hsien
SH
D000465:Algorithms; D000596:Amino Acids / Q000737:chemistry / Q000378:metabolism; D001692:Biological Transport; D002462:Cell Membrane / Q000737:chemistry / Q000378:metabolism; D007477:Ions / Q000737:chemistry*; D007700:Kinetics; D013058:Mass Spectrometry; D008564:Membrane Potentials; D008958:Models, Molecular; D010455:Peptides / Q000737:chemistry* / Q000378:metabolism; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism
D000596:Amino Acids; D007477:Ions; D010455:Peptides; D011506:Proteins