[Progress in animal models for inherited cataract].
Cataract is a serious public health problem. It is usually inherited as an autosomal dominant trait, although autosomal recessive and X-linked inheritance are seen less commonly. With the development of molecular biology techniques, a large number of inherited cataract models are produced, which will reveal the pathogenesis of cataracts and provide a new view for the development and physiology of the lens. In addition, these models also facilitate our understanding of the manner of inheritance, the effect of the environment and nutrition on the lens and provide clues for the diagnosis and treatment of cataracts. Here we presented the relative genes of the animal models for inherited cataract, mutation forms and its progress.
Yang
Xiu-Lan
XL
Laboratory Animal Center, Academy of Military Medical Science, Beijing, China. xiulanyang622@163.com
Su
Yu-Hong
YH
Li
Wen-Long
WL
D000818:Animals; D002386:Cataract / Q000235:genetics / Q000473:pathology*; D004195:Disease Models, Animal; D007908:Lens, Crystalline / Q000378:metabolism / Q000473:pathology*; D009154:Mutation