title: Eosinophilic vasculitis: a rare presentation of Whipple's disease.
abstract: Whipple's disease is a multisystem infectious disease caused by the bacterium Tropheryma whippelii. A case with an unusual presentation is reported. A 66-year-old man presented with a febrile vasculitic rash on his forearms. An extensive rheumatological, hematological and infectious workup gave negative results, apart from mild anemia and eosinophilia. An abdominal computed tomography revealed a retroperitoneal lymphadenopathy, and a skin biopsy revealed an eosinophilic vasculitis. This diverted the work toward ruling out a lymphoma or a vasculitic process. A lymph node biopsy was then performed and showed a diffuse neutrophilic inflammation with abundant foamy macrophages, fat necrosis and lipogranuloma formation. These findings were considered to be nonspecific and no further pathological investigation was carried out. After a course of corticosteroids, diarrhea and weight loss predominated and subsequently a diagnosis of Whipple's disease was confirmed on a small-bowel biopsy. Lymph node involvement was then confirmed on re-evaluation using the appropriate stains.
authors: University of Western Ontario, London, Canada. walhamoudi@gmail.com
authors: Waleed
authors: W
authors: Al-Hamoudi
authors: Fadi
authors: F
authors: Habbab
authors: Carmine
authors: C
authors: Nudo
authors: Ayoub
authors: A
authors: Nahal
authors: Kenneth
authors: K
authors: Flegel
mesh_terms: D000368:Aged; D004802:Eosinophilia / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D008297:Male; D017445:Skin Diseases, Vascular / Q000150:complications* / Q000175:diagnosis; D014657:Vasculitis / Q000150:complications* / Q000175:diagnosis; D008061:Whipple Disease / Q000150:complications / Q000175:diagnosis*