title: Failure to detect infection by oral polio vaccine virus following natural exposure among inactivated polio vaccine recipients.
abstract: While oral polio vaccine (OPV) has been shown to be safe and effective, it has been observed that it can circulate within a susceptible population and revert to a virulent form. Inactivated polio vaccine (IPV) confers protection from paralytic disease, but provides limited protection against infection. It is possible, then, that an IPV-immunized population, when exposed to OPV, could sustain undetected circulation of vaccine-derived poliovirus. This study examines the possibility of polio vaccine virus circulating within the United States (highly IPV-immunized) population that borders Mexico (OPV-immunized). A total of 653 stool and 20 sewage samples collected on the US side of the border were tested for the presence of poliovirus. All samples were found to be negative. These results suggest that the risk of circulating vaccine-derived poliovirus is low in fully immunized IPV-using populations in developed countries that border OPV-using populations.
authors: Centers for Disease Control and Prevention, Atlanta, GA 30333, USA. hgary@cdc.gov
authors: H E
authors: HE
authors: Gary
authors: B
authors: B
authors: Smith
authors: J
authors: J
authors: Jenks
authors: J
authors: J
authors: Ruiz
authors: W
authors: W
authors: Sessions
authors: J
authors: J
authors: Vinje
authors: M
authors: M
authors: Sobsey
mesh_terms: D002675:Child, Preschool; D005243:Feces / Q000821:virology; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D011051:Poliomyelitis / Q000175:diagnosis*; D017955:Poliovirus / Q000254:growth & development* / Q000276:immunology; D011054:Poliovirus Vaccine, Inactivated / Q000276:immunology*; D012722:Sewage / Q000821:virology; D014481:United States; D017201:Virus Shedding
chemical_list: D011054:Poliovirus Vaccine, Inactivated; D012722:Sewage