[KAP-1, a scaffold protein in transcription regulation].
KAP-1 (Alternative names: TIF1beta or TRIM28) is one member of transcriptional intermediary factors, which acts as a scaffold in many transcription regulation complexes. The N-terminal RBCC domain of KAP-1 can interact with KRAB-ZFPs, MDM2, MM1, C/EBPbeta, etc. KAP-1's C-terminal PHD and Bromodomain is two integrated transcriptional repression domains, which interact with SETDB1, Mi-2alpha and other proteins to form complexes with histone deacetylase or methyltransferase activity. In addition, KAP-1 can interact with HP1s (heterochromatin protein 1) and then bind to histones via its HP1BD which is a small segment in the central region of KAP-1. It is indicated by many researches that KAP-1, a scaffold protein in transcription regulation, mainly acts as a corepressor in many repression complexes. Meanwhile, it also acts as a coactivator sometimes. It is reported that KAP-1 related transcription regulation complexes exert functions essential for spermiogenesis and early embryo development. This regulation is one pattern of epigenetic regulations.
Yang
Dong
D
Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing, China. yangdong@hupo.org.cn
Jiang
Ying
Y
He
Fu-Chu
FC
D000818:Animals; D000090266:Chromobox Protein Homolog 5; D002868:Chromosomal Proteins, Non-Histone / Q000378:metabolism / Q000502:physiology; D004268:DNA-Binding Proteins / Q000378:metabolism / Q000502:physiology*; D005786:Gene Expression Regulation; D006801:Humans; D011485:Protein Binding; D012097:Repressor Proteins / Q000378:metabolism / Q000502:physiology*; D014158:Transcription, Genetic / Q000235:genetics; D000076183:Tripartite Motif-Containing Protein 28
D002868:Chromosomal Proteins, Non-Histone; D004268:DNA-Binding Proteins; D012097:Repressor Proteins; D000090266:Chromobox Protein Homolog 5; C101116:TRIM28 protein, human; D000076183:Tripartite Motif-Containing Protein 28