On again, off again: the SRC-3 transcriptional coactivator moonlights as a translational corepressor.
In a recent issue of Molecular Cell, Yu et al. (2007) reported that the steroid receptor coactivator-3 (SRC-3) has a novel cytoplasmic function: it activates the translational silencers TIA-1 and TIAR and thus inhibits the translation of proinflammatory cytokines.
Anderson
Paul
P
Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Smith 652, One Jimmy Fund Way, Boston, MA 02115, USA.
Kedersha
Nancy
N
D000818:Animals; D002467:Cell Nucleus / Q000502:physiology; D051548:Histone Acetyltransferases / Q000378:metabolism*; D006801:Humans; D056921:Nuclear Receptor Coactivator 3; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000235:genetics; D015534:Trans-Activators / Q000378:metabolism*; D014158:Transcription, Genetic; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics
D012333:RNA, Messenger; D015534:Trans-Activators; D014409:Tumor Necrosis Factor-alpha; D051548:Histone Acetyltransferases; C538866:NCOA3 protein, human; D056921:Nuclear Receptor Coactivator 3