title: A high-fat meal increases cardiovascular reactivity to psychological stress in healthy young adults.
abstract: The consumption of high levels of saturated fat over the course of several weeks may lead to exaggerated cardiovascular reactivity. The consumption of a single high-fat meal has been associated with a transient impairment of vascular function. In a randomized, repeated measures, crossover study we tested whether the consumption of a single high-fat meal by healthy, normotensive participants would affect cardiovascular reactivity when compared with an isocaloric, low-fat meal. Thirty healthy participants ate a high-fat (42 g) and a low-fat (1 g) meal on 2 separate occasions, and their cardiovascular response to 2 standard laboratory stressors was measured. Systolic blood pressure, diastolic blood pressure, and total peripheral resistance were greater in participants following the consumption of the high-fat meal relative to the low-fat meal. The findings of the present study are consistent with the hypothesis that even a single high-fat meal may be associated with heightened cardiovascular reactivity to stress and offer insight into the pathways through which a high-fat diet may affect cardiovascular function.
authors: University of Calgary, Department of Psychology, Calgary, AB, Canada T2N 1N4.
authors: Fabijana
authors: F
authors: Jakulj
authors: Kristin
authors: K
authors: Zernicke
authors: Simon L
authors: SL
authors: Bacon
authors: Laura E
authors: LE
authors: van Wielingen
authors: Brenda L
authors: BL
authors: Key
authors: Sheila G
authors: SG
authors: West
authors: Tavis S
authors: TS
authors: Campbell
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001794:Blood Pressure / Q000187:drug effects; D002319:Cardiovascular System / Q000187:drug effects* / Q000503:physiopathology*; D018592:Cross-Over Studies; D003971:Diastole; D004041:Dietary Fats / Q000008:administration & dosage* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D013315:Stress, Psychological / Q000503:physiopathology*; D013599:Systole; D014655:Vascular Resistance / Q000187:drug effects
chemical_list: D004041:Dietary Fats