title: Sandblasted titanium osteointegration in young, aged and ovariectomized sheep.
abstract: To evaluate how aging and estrogen deficiency influence the success rate of Sandblasted Titanium (Ti/SA) implants, the osteointegration of Ti/SA rods was studied in the cortical and trabecular bone of 5 young, 5 aged and 5 ovariectomized (OVX) sheep. The characterization of the host bone by transiliac biopsies of the iliac crest showed a progressive rarefaction of trabecular bone in aged and OVX animals when compared to young ones. A significant reduction, both in cortical and trabecular bone, of the osteointegration rate of Ti/SA rods in the presence of estrogen deficiency compared to young animals was observed, while only a minor reduction was observed in aged animals. These results were confirmed by the pushout test in cortical bone. Bone quality affected the biological response of bone to Ti/SA implants in both trabecular and cortical bone; consequently, strategies to maximize the bone osteogenic properties of osteoporotic patients should be adopted.
authors: Experimental Surgery Department, Research Institute Codivilla-Putti, Rizzoli Orthopedic Institute, Bologna, Italy.
authors: V
authors: V
authors: Borsari
authors: M
authors: M
authors: Fini
authors: G
authors: G
authors: Giavaresi
authors: L
authors: L
authors: Rimondini
authors: R
authors: R
authors: Chiesa
authors: L
authors: L
authors: Chiusoli
authors: R
authors: R
authors: Giardino
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D001696:Biomechanical Phenomena; D004967:Estrogens / Q000502:physiology*; D005260:Female; D016348:Osseointegration / Q000502:physiology*; D010024:Osteoporosis / Q000503:physiopathology; D010052:Ovariectomy; D019736:Prostheses and Implants; D034561:Sheep, Domestic; D013499:Surface Properties; D014025:Titanium
chemical_list: D004967:Estrogens; D014025:Titanium