title: Serum IGF-I, its major binding protein (IGFBP-3) and epithelial ovarian cancer risk: the European Prospective Investigation into Cancer and Nutrition (EPIC).
abstract: We set out to study the relationship between circulating levels of IGF-I and its major binding protein (IGFBP-3) in relation to ovarian cancer risk. We conducted a case-control study nested within the European Prospective Investigation into Cancer and Nutrition. Levels of IGF-I and IGFBP-3 were measured in prediagnostic serum samples of 214 women who subsequently developed ovarian cancer, and 388 matched control subjects. Conditional logistic regression models were used to estimate relative risks of ovarian cancer by tertiles of IGF-I and IGFBP-3 levels. For all women, there was no association between the circulating IGF-I or IGFBP-3 levels and the risk of ovarian cancer. However, among women diagnosed with ovarian cancer aged 55 or younger, the relative risk was higher in the middle or top tertiles of serum IGF-I, when compared with women in the lowest tertile (odds ratios (OR) = 1.8 (95%CI 0.7-4.3) and OR = 2.4 (95%CI 0.9-6.4); P(trend) = 0.08) respectively. These results were adjusted for body mass index, previous hormone use, fertility problems, and parity. Restricting the analysis to women who were premenopausal at blood donation, relative risks for ovarian cancer diagnosed before age 55 were higher (OR = 5.1 (95%CI 1.5-18.2) and OR = 5.6 (95%CI 1.5-20.8) respectively, for second and third tertiles; P(trend) = 0.02). Adjustment for serum IGFBP-3 levels only slightly attenuated relative risk estimates. Relations between IGFBP-3 and ovarian cancer before age 55 were in the same direction as for IGF-I, but less strong and statistically not significant. In women aged over 55, there was no association between serum IGF-I or IGFBP-3 and ovarian cancer risk. Our results suggest that the circulating levels of IGF-I may play a potentially important role in the development of ovarian cancer in women of a pre- or perimenopausal age.
authors: Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.
authors: Petra H M
authors: PH
authors: Peeters
authors: Annekatrin
authors: A
authors: Lukanova
authors: Naomi
authors: N
authors: Allen
authors: Franco
authors: F
authors: Berrino
authors: Tim
authors: T
authors: Key
authors: Laure
authors: L
authors: Dossus
authors: Sabina
authors: S
authors: Rinaldi
authors: Carla H
authors: CH
authors: van Gils
authors: H Bas
authors: HB
authors: Bueno-de-Mesquita
authors: Heiner
authors: H
authors: Boeing
authors: Mandy
authors: M
authors: Schulz
authors: Jenny
authors: J
authors: Chang-Claude
authors: Jakob
authors: J
authors: Linseisen
authors: Salvatore
authors: S
authors: Panico
authors: Carlotta
authors: C
authors: Sacerdote
authors: Domenico
authors: D
authors: Palli
authors: Rosario
authors: R
authors: Tumino
authors: Antonia
authors: A
authors: Trichopoulou
authors: Dimitrios
authors: D
authors: Trichopolos
authors: Christina
authors: C
authors: Bamia
authors: Nerea
authors: N
authors: Larranaga
authors: Eva
authors: E
authors: Ardanaz
authors: Guillem
authors: G
authors: Pera
authors: J Ramón
authors: JR
authors: Quirós
authors: Carmen
authors: C
authors: Martínez-García
authors: Carmen
authors: C
authors: Navarro
authors: Sheila A
authors: SA
authors: Bingham
authors: Kay-Tee
authors: KT
authors: Khaw
authors: Françoise
authors: F
authors: Clavel
authors: Anne
authors: A
authors: Tjonneland
authors: Anja
authors: A
authors: Olsen
authors: Kim
authors: K
authors: Overvad
authors: Mette S
authors: MS
authors: Tetsche
authors: Eiliv
authors: E
authors: Lund
authors: Eva
authors: E
authors: Lundin
authors: Göran
authors: G
authors: Berglund
authors: Elio
authors: E
authors: Riboli
authors: R
authors: R
authors: Kaaks
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005060:Europe / Q000453:epidemiology; D005260:Female; D006801:Humans; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000097:blood; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D008875:Middle Aged; D009375:Neoplasms, Glandular and Epithelial / Q000097:blood* / Q000453:epidemiology; D010051:Ovarian Neoplasms / Q000097:blood* / Q000453:epidemiology; D017697:Premenopause / Q000097:blood; D011446:Prospective Studies; D012307:Risk Factors
chemical_list: D018972:Insulin-Like Growth Factor Binding Protein 3; D007334:Insulin-Like Growth Factor I