title: Validation of the peak to mean pressure decrease ratio as a new method of assessing aortic stenosis using the Gorlin formula and the cardiovascular magnetic resonance-based hybrid method.
abstract: BACKGROUND
  We sought to validate the recently introduced peak to mean pressure decrease ratio (PMPDR), using the Gorlin formula and a hybrid method which combines cardiovascular magnetic resonance (CMR)-derived stroke volume with transaortic Doppler measurements to calculate aortic valve area (AVA).
  
  
  METHODS
  Data analysis in 32 patients with severe (AVA <or= 0.75 cm(2)) or moderate aortic stenosis who had prospectively been entered into our aortic stenosis database.
  
  
  RESULTS
  Gorlin-derived AVA was 0.61 +/- 0.10 cm(2) in severe and 0.92 +/- 0.14 cm(2) in moderate aortic stenosis (P < 0.01). Corresponding values for PMPRD were 1.61 +/- 0.10 and 1.73 +/- 0.18, respectively (P < 0.05). Sensitivity, specificity, positive and negative predictive values for PMPDR <1.5 to predict severe aortic stenosis were 0.12, 0.92, 0.67, and 0.44 as assessed by the Gorlin formula.
  
  
  CONCLUSIONS
  Using the Gorlin formula as the reference standard, our study confirms results of a previously reported study on the performance of PMPDR for assessment of aortic stenosis.
authors: Medical Department, University Hospital Mannheim, Mannheim, Germany.
authors: Dariusch
authors: D
authors: Haghi
authors: Jens J
authors: JJ
authors: Kaden
authors: Tim
authors: T
authors: Suselbeck
authors: Stephan
authors: S
authors: Fluechter
authors: Ole A
authors: OA
authors: Breithardt
authors: Tudor
authors: T
authors: Poerner
authors: Gabor
authors: G
authors: Kalmar
authors: Martin
authors: M
authors: Borggrefe
authors: Theano
authors: T
authors: Papavassiliu
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001024:Aortic Valve Stenosis / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000503:physiopathology*; D001783:Blood Flow Velocity; D001794:Blood Pressure; D006328:Cardiac Catheterization; D015150:Echocardiography, Doppler / Q000379:methods; D004562:Electrocardiography; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D019028:Magnetic Resonance Imaging, Cine / Q000379:methods*; D008297:Male; D015588:Observer Variation; D011446:Prospective Studies; D012107:Research Design; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D013318:Stroke Volume