Protein F1 and Streptococcus pyogenes resistance to phagocytosis.
Streptococcus pyogenes is a major cause of pharyngitis in humans and encodes several fibronectin-binding proteins. M protein and protein F1 (PrtF1/SfbI) are differentially regulated by CO(2) and O(2), respectively, and both mediate the invasion of epithelial cells. This study examined whether PrtF1/SfbI shares other properties with M protein. Expression of the PrtF1/SfbI protein by an M-negative mutant conferred resistance to phagocytosis and partial inhibition of C3 deposition on the S. pyogenes surface.
Hyland
Kendra A
KA
Department of Microbiology, University of Minnesota Medical School, MMC196, 420 Delaware Street S.E., Minneapolis, MN 55455, USA. hyla0021@umn.edu
Wang
Beinan
B
Cleary
P Patrick
PP
D018829:Adhesins, Bacterial / Q000235:genetics / Q000378:metabolism*; D002460:Cell Line; D004847:Epithelial Cells / Q000382:microbiology*; D006801:Humans; D010587:Phagocytosis / Q000502:physiology*; D013297:Streptococcus pyogenes / Q000378:metabolism*
D018829:Adhesins, Bacterial; C078635:fibronectin-binding proteins, bacterial