title: Immunogenicity of varying dosages of 7-valent pneumococcal polysaccharide-protein conjugate vaccine in seniors previously vaccinated with 23-valent pneumococcal polysaccharide vaccine.
abstract: In this dose-ranging study 220 seniors who had received the 23-valent pneumococcal polysaccharide (PnPS) vaccine at least 5 years prior to enrollment were assigned to receive one of four volumes (0.1, 0.5, 1 or 2 ml) of 7-valent pneumococcal conjugate (PnC) vaccine or a 0.5 ml dose of 23-valent PnPS vaccine. All participants received a reduced challenge dose of 0.1 ml of PnPS vaccine 1 year after enrollment. There was evidence of a dose response to PnC vaccine and antibody levels in the 1 ml PnC group tended to be significantly higher than in the PnPS group. A booster response to the challenge vaccination was not observed. Administration of a 1 ml dose of PnC vaccine is more immunogenic than 0.5 ml of PnPS vaccine in elderly adults previously vaccinated with PnPS vaccine.
authors: Group Health Center for Health Studies, 1730 Minor Ave, Ste 1600, Seattle, WA 98101, USA. Jackson.L@ghc.org
authors: Lisa A
authors: LA
authors: Jackson
authors: Kathleen M
authors: KM
authors: Neuzil
authors: Moon H
authors: MH
authors: Nahm
authors: Cynthia G
authors: CG
authors: Whitney
authors: Onchee
authors: O
authors: Yu
authors: Jennifer C
authors: JC
authors: Nelson
authors: Pat T
authors: PT
authors: Starkovich
authors: Maya
authors: M
authors: Dunstan
authors: Barbara
authors: B
authors: Carste
authors: David K
authors: DK
authors: Shay
authors: James
authors: J
authors: Baggs
authors: George M
authors: GM
authors: Carlone
mesh_terms: D000368:Aged; D000907:Antibodies, Bacterial / Q000096:biosynthesis / Q000097:blood; D004306:Dose-Response Relationship, Immunologic; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005260:Female; D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D006801:Humans; D008297:Male; D022401:Meningococcal Vaccines / Q000008:administration & dosage* / Q000009:adverse effects; D022242:Pneumococcal Vaccines / Q000008:administration & dosage* / Q000009:adverse effects
chemical_list: D000907:Antibodies, Bacterial; D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D022401:Meningococcal Vaccines; D022242:Pneumococcal Vaccines