Estimation on the individual hydrogen-bond strength in molecules with multiple hydrogen bonds.
A simple atom-replacement approach is proposed for estimating the individual contributions of each intermolecular hydrogen bond (HB) in multiple hydrogen-bonded systems. The approach is validated by calculations on the homodimer of formylformamide and then applied to nucleic acid base pairs (adenine-thymine and guanine-cytosine) and some quadruply hydrogen-bonded dimers. With the help of this method, it is easy to distinguish the relative strength of each HB, and identify the main factors contributing to the total binding energies of multiple HBs.
Dong
Hao
H
School of Chemistry and Chemical Engineering, Institute of Theoretical and Computational Chemistry, Lab of Mesoscopic Chemistry, Nanjing University, Nanjing, 210093, People's Republic of China.
Hua
Weijie
W
Li
Shuhua
S
D000225:Adenine / Q000737:chemistry; D020029:Base Pairing; D002627:Chemistry, Physical / Q000379:methods*; D003596:Cytosine / Q000737:chemistry; D019281:Dimerization; D005559:Formamides / Q000737:chemistry*; D006147:Guanine / Q000737:chemistry; D006859:Hydrogen; D006860:Hydrogen Bonding; D008956:Models, Chemical; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D013941:Thymine / Q000737:chemistry
D005559:Formamides; D006147:Guanine; D006859:Hydrogen; D003596:Cytosine; D000225:Adenine; D013941:Thymine