Raised alanine transaminase and decreased adiponectin are features of the metabolic syndrome in patients with type 2 diabetes.
OBJECTIVE
The aim of the study was to investigate the relationship between the metabolic syndrome (MS), adiponectin and abnormal liver enzymes in patients with type 2 diabetes.


METHODS
Fasting serum was collected from 189 patients with type 2 diabetes, adiponectin was measure using radioimmunoassay and features of the MS were assessed.


RESULTS
Mean ALT was significantly higher in patients with the MS and higher ALT was associated with lower adiponectin levels. As the number of features of MS increased, ALT increased and adiponectin decreased independent of glycaemic control.


CONCLUSIONS
Hypoadiponectinemia and the MS may be linked with liver injury in patients with type 2 diabetes.
Hickman
Ingrid J
IJ
Centre for Diabetes and Endocrine Research, University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland, Australia. ihickman@cder.soms.uq.edu.au
Whitehead
Jonathan P
JP
Prins
Johannes B
JB
Macdonald
Graeme A
GA
D052242:Adiponectin / Q000097:blood*; D000410:Alanine Transaminase / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications / Q000188:drug therapy; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D008099:Liver / Q000201:enzymology; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000150:complications; D008875:Middle Aged; D012737:Sex Factors
D052242:Adiponectin; D000410:Alanine Transaminase; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents