Effect of beta-endorphin on production of antibodies and IL-4 under conditions of opioid receptor blockade.
beta-Endorphin in vivo produced different effects on antibody production depending on the administered dose. Blockade of opioid receptors with naloxone (but not naltrindole) abolished the effects of beta-endorphin. The peptide activated IL-4 production in vitro via activation of delta-opioid receptors.
Gein
S V
SV
Analytic Laboratory of Institute of Ecology and Genetics of Microorganisms, Ural Division of Russian Academy of Sciences, Perm'. gein@iegm.ru.
Baeva
T A
TA
Kichanova
O A
OA
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006968:Hypersensitivity, Delayed / Q000209:etiology; D015847:Interleukin-4 / Q000378:metabolism; D008213:Lymphocyte Activation / Q000187:drug effects; D008297:Male; D051379:Mice; D009270:Naloxone / Q000494:pharmacology; D009271:Naltrexone / Q000031:analogs & derivatives / Q000494:pharmacology; D009292:Narcotic Antagonists; D010835:Phytohemagglutinins; D001615:beta-Endorphin / Q000494:pharmacology*
D009292:Narcotic Antagonists; D010835:Phytohemagglutinins; D015847:Interleukin-4; D009270:Naloxone; D009271:Naltrexone; D001615:beta-Endorphin; C055382:naltrindole