Pimecrolimus cream in repigmentation of vitiligo.
BACKGROUND
Vitiligo is a chronic disease that mostly affects children and young adults. Nowadays many treatment options are available; however, most of them have limited efficacy and in most cases would result in undesirable complications.


OBJECTIVE
To determine the extent of repigmentation according to the location of the lesions after applying topical cream pimecrolimus 1% in vitiligo patients.


METHODS
Thirty consecutive patients with vitiligo lesions affecting less than 20% of body surface area without any previous history of spontaneous repigmentation were treated with pimecrolimus cream 1% twice daily for 12 weeks. The extent of repigmentation in vitiligo lesions was determined in each patient after 6 and 12 weeks.


RESULTS
Moderate to excellent response (repigmentation >26%) was observed in 6.6 and 25.9% of vitiligo lesions 6 and 12 weeks after treatment, respectively. More responsive lesions were located on the trunk, face and elbow (85.7, 75 and 70%).


CONCLUSIONS
Pimecrolimus cream 1% results in repigmentation in vitiligo in different extents according to the location of the lesion; however, to clearly prove its efficacy as monotherapy or in combination with other available treatment options, double-blind placebo-controlled studies are essential.
Seirafi
Hassan
H
Tehran University of Medical Sciences, Tehran, Iran. hassan_seirafi@yahoo.com
Farnaghi
Farshad
F
Firooz
Alireza
A
Vasheghani-Farahani
Amir
A
Alirezaie
Najmeh-Sadaat
NS
Dowlati
Yahya
Y
D000293:Adolescent; D000328:Adult; D002648:Child; D003879:Dermatologic Agents / Q000008:administration & dosage*; D006801:Humans; D008875:Middle Aged; D009824:Ointments; D012880:Skin Pigmentation / Q000187:drug effects; D016559:Tacrolimus / Q000008:administration & dosage / Q000031:analogs & derivatives*; D014820:Vitiligo / Q000188:drug therapy*
D003879:Dermatologic Agents; D009824:Ointments; C117268:pimecrolimus; D016559:Tacrolimus