Mesenchymal-epithelial transformation of ito cells in vitro.
Cultured pure population of Ito cells isolated from adult rat liver expressed epithelial markers cytokeratin-8, alpha-fetoprotein, and gamma-glutamyl transpeptidase after forming a dense monolayer. Mesenchymal-epithelial transformation of these cells is possible, which suggests them as candidates of hepatic stem cells.
Kiyasov
A P
AP
Kazan State Medical University. kiassov@mail.ru
Gumerova
A A
AA
Titova
M A
MA
D000818:Animals; D002454:Cell Differentiation / Q000502:physiology*; D004847:Epithelial Cells / Q000166:cytology*; D022781:Hepatocytes / Q000378:metabolism* / Q000502:physiology; D007150:Immunohistochemistry; D053533:Keratin-8 / Q000378:metabolism; D008297:Male; D008648:Mesoderm / Q000166:cytology*; D051381:Rats; D013234:Stem Cells / Q000166:cytology / Q000378:metabolism*; D000509:alpha-Fetoproteins / Q000378:metabolism; D005723:gamma-Glutamyltransferase / Q000378:metabolism
D053533:Keratin-8; D000509:alpha-Fetoproteins; D005723:gamma-Glutamyltransferase