title: Mood stability during acute stimulator challenge in Parkinson's disease patients under long-term treatment with subthalamic deep brain stimulation.
abstract: Acute and chronic behavioral effects of subthalamic stimulation (STN-DBS) for Parkinson's disease (PD) are reported in the literature. As the technique is relatively new, few systematic studies on the behavioral effects in long-term treated patients are available. To further study the putative effects of STN-DBS on mood and emotional processing, 15 consecutive PD patients under STN-DBS for at least 1 year, were tested ON and OFF stimulation while on or off medication, with instruments sensitive to short-term changes in mood and in emotional discrimination. After acute changes in experimental conditions, mood core dimensions (depression, elation, anxiety) and emotion discrimination processing remained remarkably stable, in the face of significant motor changes. Acute stimulator challenge in long-term STN-DBS-treated PD patients does not appear to provoke clinically relevant mood effects.
authors: Department of Psychiatry, McGill University, Montreal, Canada.
authors: Alexandre
authors: A
authors: Berney
authors: Michel
authors: M
authors: Panisset
authors: Abbas F
authors: AF
authors: Sadikot
authors: Alain
authors: A
authors: Ptito
authors: Alain
authors: A
authors: Dagher
authors: Maria
authors: M
authors: Fraraccio
authors: Ghislaine
authors: G
authors: Savard
authors: Marc
authors: M
authors: Pell
authors: Chawki
authors: C
authors: Benkelfat
mesh_terms: D046690:Deep Brain Stimulation / Q000379:methods*; D005260:Female; D007839:Functional Laterality; D006801:Humans; D008297:Male; D008875:Middle Aged; D019964:Mood Disorders / Q000175:diagnosis / Q000209:etiology*; D010300:Parkinson Disease / Q000523:psychology* / Q000628:therapy*; D020531:Subthalamic Nucleus / Q000502:physiology*; D016896:Treatment Outcome