Luminescence functionalization of SBA-15 by YVO4:Eu3+ as a novel drug delivery system.
Luminescence functionalization of the ordered mesoporous SBA-15 silica was realized by depositing a YVO4:Eu3+ phosphor layer on its surface via the Pechini sol-gel process, resulting in the formation of the YVO4:Eu3+@SBA-15 composite material. This material, which combines the mesoporous structure of SBA-15 and the strong red luminescence property of YVO4:Eu3+, can be used as a novel functional drug delivery system. The structure, morphology, porosity, and optical properties of the materials were well characterized by X-ray diffraction, Fourier transform infrared spectroscopy, scanning electron microscopy, transmission electron microscopy, N2 adsorption, and photoluminescence spectra. As expected, the pore volume, surface area, and pore size of SBA-15 decrease in sequence after deposition of the YVO4:Eu3+ layer and the adsorption of ibuprofen (IBU, drug). The IBU-loaded YVO4:Eu3+@SBA-15 system still shows the red emission of Eu3+ (617 nm, 5D0-7F2) under UV irradiation and the controlled drug release property. Additionally, the emission intensity of Eu3+ increases with an increase in the cumulative released amount of IBU in the system, making the extent of drug release easily identifiable, trackable, and monitorable by the change of luminescence. The system has great potential in the drug delivery and disease therapy fields.
Yang
Piaoping
P
Key Laboratory of Rare Earth Chemistry and Physics, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China.
Huang
Shanshan
S
Kong
Deyan
D
Lin
Jun
J
Fu
Honggang
H
D000327:Adsorption; D004337:Drug Carriers / Q000737:chemistry*; D005063:Europium / Q000737:chemistry*; D007052:Ibuprofen / Q000737:chemistry; D049449:Luminescence; D008855:Microscopy, Electron, Scanning / Q000379:methods; D046529:Microscopy, Electron, Transmission / Q000379:methods; D009584:Nitrogen / Q000737:chemistry; D010316:Particle Size; D010777:Photochemistry; D016062:Porosity; D012680:Sensitivity and Specificity; D012822:Silicon Dioxide / Q000138:chemical synthesis / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods; D013499:Surface Properties; D017968:Vanadium Compounds / Q000737:chemistry*; D014961:X-Ray Diffraction; D015018:Ytterbium / Q000737:chemistry*
D004337:Drug Carriers; C509969:SBA-15; D017968:Vanadium Compounds; D005063:Europium; D012822:Silicon Dioxide; D015018:Ytterbium; D009584:Nitrogen; D007052:Ibuprofen