title: Chlorpyrifos increases the levels of hippocampal NMDA receptor subunits NR2A and NR2B in juvenile and adult rats.
abstract: The present study investigated the effect of chlorpyrifos on NMDA receptor subunits NR2A and NR2B in juvenile and adult rats. Chlorpyrifos was administered with the dose of 40 and 70 mg/kg to juvenile and adult rats, respectively. Chlorpyrifos significantly inhibited the AChE activity in juvenile and adult rats (p < .05). NR2A and NR2B levels significantly increased in juvenile and adult rats by chlorpyrifos application (p < .05). Increased NR2A and NR2B levels may reflect increased glutaminergic activity, consequently neuronal damage. In the case of neuronal damage, learning and memory could be affected negatively even though NR2A and NR2B increased.
authors: Suleyman Demirel University, School of Medicine, Department of Biochemistry, Isparta, Turkey. fatih@sdu.edu.tr
authors: Fatih
authors: F
authors: Gultekin
authors: Inanc
authors: I
authors: Karakoyun
authors: Recep
authors: R
authors: Sutcu
authors: Emin
authors: E
authors: Savik
authors: Gokhan
authors: G
authors: Cesur
authors: Hikmet
authors: H
authors: Orhan
authors: Namik
authors: N
authors: Delibas
mesh_terms: D000110:Acetylcholinesterase / Q000097:blood / Q000187:drug effects* / Q000378:metabolism; D000367:Age Factors; D000818:Animals; D004390:Chlorpyrifos / Q000633:toxicity*; D002800:Cholinesterase Inhibitors / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism; D007306:Insecticides / Q000633:toxicity*; D008297:Male; D021122:Protein Subunits; D051381:Rats; D017207:Rats, Sprague-Dawley; D016194:Receptors, N-Methyl-D-Aspartate / Q000187:drug effects* / Q000378:metabolism; D018709:Statistics, Nonparametric
chemical_list: D002800:Cholinesterase Inhibitors; D007306:Insecticides; C120997:NR2A NMDA receptor; C121001:NR2B NMDA receptor; D021122:Protein Subunits; D016194:Receptors, N-Methyl-D-Aspartate; D000110:Acetylcholinesterase; D004390:Chlorpyrifos