title: Stereoselective synthesis of bis-steroidal pyrazine derivatives.
abstract: Some compounds of Cephalostatin family have shown anti-cancer activity against human cancer cell line and active intensity has close with the stereochemistry of the substituted group, for example, beta-OH at C-12 in compound 2 showed less promising results and the mixture 3 (alpha + beta) showed a large enhancement of the activity compared to the compound 2. So, the work was concentrated on the synthesis diastereomers 10 and 11 were obtained in a pure form.
authors: Basic Sciences Department, Faculty of Engineering Technology, Al-Balqa University, Marka, Amman, Jordan. mnawasra@just.edu.jo
authors: M
authors: M
authors: Nawasreh
mesh_terms: D008956:Models, Chemical; D015394:Molecular Structure; D010619:Phenazines / Q000737:chemistry; D011719:Pyrazines / Q000138:chemical synthesis* / Q000737:chemistry; D013141:Spiro Compounds / Q000737:chemistry; D013237:Stereoisomerism; D013256:Steroids / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D010619:Phenazines; D011719:Pyrazines; D013141:Spiro Compounds; D013256:Steroids; C454806:cephalostatin I