Potential genetic variants in schizophrenia: a Bayesian analysis.
A number of different gene polymorphisms have been found to dispose for the development of schizophrenia. However, no single gene polymorphism is sufficient for the precipitation of schizophrenia. Swedish psychosis patients (n=103) and control subjects (n=89) were analyzed for 36 single nucleotide polymorphisms in 30 candidate genes for schizophrenia. Evidence of association was analyzed with Bayesian statistical methods. Variants in the genes coding for dopamine-D2 receptor, brain-derived neurotrophic factor (BDNF), neuropeptide Y (NPY), neuregulin 1, reelin and synapsin 3 showed association with schizophrenia, although few subjects were found in the minority allele for the two latter variants. The six gene variants, all with suspected connection to schizophrenia, were found to be risk factors when considered in combination, but not separately. The results indicate that the Bayesian statistical method gives additional possibilities in the search for risk factors for schizophrenia or other complex disorders.
Hall
Håkan
H
Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden. hakan.hall@ge.com
Lawyer
Glenn
G
Sillén
Anna
A
Jönsson
Erik G
EG
Agartz
Ingrid
I
Terenius
Lars
L
Arnborg
Stefan
S
D000328:Adult; D000483:Alleles; D001499:Bayes Theorem; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics; D015816:Cell Adhesion Molecules, Neuronal / Q000235:genetics; D002874:Chromosome Mapping; D016326:Extracellular Matrix Proteins / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D014644:Genetic Variation / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000235:genetics; D020890:Neuregulin-1; D009478:Neuropeptide Y / Q000235:genetics; D009479:Neuropeptides / Q000235:genetics; D010750:Phosphoproteins / Q000235:genetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011618:Psychotic Disorders / Q000235:genetics*; D017448:Receptors, Dopamine D2 / Q000235:genetics; D000091042:Reelin Protein; D012307:Risk Factors; D012559:Schizophrenia / Q000235:genetics*; D012697:Serine Endopeptidases / Q000235:genetics; D016704:Synapsins
D019208:Brain-Derived Neurotrophic Factor; D015816:Cell Adhesion Molecules, Neuronal; D016326:Extracellular Matrix Proteins; C094131:NRG1 protein, human; D009419:Nerve Tissue Proteins; D020890:Neuregulin-1; D009478:Neuropeptide Y; D009479:Neuropeptides; D010750:Phosphoproteins; D017448:Receptors, Dopamine D2; D000091042:Reelin Protein; C111812:SYN3 protein, human; D016704:Synapsins; C000717127:RELN protein, human; D012697:Serine Endopeptidases