title: Dysplastic nodules and small primary carcinoma of the liver: a study detecting the early morphological changes during hepatocarcinogenesis.
abstract: OBJECTIVE
  Detect the early histological changes relating to human hepatocarcinogenesis in three nodular hepatocellular lesions.
  
  
  METHODS
  Three cases of dysplastic nodules and one of small hepatocellular carcinoma were obtained from the authors' surgical-pathology file during 2000-2005 for a histopathological study in relevance to the early changes during hepatocarcinogenesis by employing hematoxylin and eosin stain, as well as some immunohistochemical staining.
  
  
  RESULTS
  One nodular hepatocellular lesion, diagnosed as a complex lesion of focal nodular hyperplasia contained a microscopic focus (1.5 mm in diameter) of combined hepatocellular and cholangiocarcinoma.
  
  
  CONCLUSIONS
  The small dysplastic hepatocytes subjected to neoplastic transformation combined hepatocellular and cholangiocarcinoma and are the precursorial cells of hepatocellular carcinoma. Chronic viral hepatitis B or C, aflatoxin B, and nitrosamine(s), as well as some nodular hepatocellular lesions share distinct roles in the complex process of hepatocarcinogenesis pertaining to this Southeast Asian country.
authors: Department of Pathology, Ramathibodi Hospital, Bangkok, Thailand.
authors: Pattana
authors: P
authors: Sornmayura
authors: Paisan
authors: P
authors: Boonsakan
authors: Abhasnee
authors: A
authors: Sobhonslidsuk
authors: Suthus
authors: S
authors: Sriphojanart
authors: Chakrapan
authors: C
authors: Euanorasetr
authors: Sukhum
authors: S
authors: Bunyaratvej
mesh_terms: D000328:Adult; D042241:Early Diagnosis; D005260:Female; D022781:Hepatocytes / Q000473:pathology*; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013997:Time Factors