[Cytomegalovirus and cryptogenic inflammatory bowel disease].
CMV infection has been reported in association with some flares of IBD. Its prevalence varies with the method of diagnosis and the severity of IBD. Although the link between CMV and IBD is not clear, the immunomodulator properties of the virus may play a role in the evolution of IBD. Besides the necessity of immunosuppression to treat IBD, inflammation per se can maintain in situ viral replication. Antiviral treatment can be useful in some situations. New molecular methods will permit earlier and more sensitive diagnosis of CMV infection and a better evaluation of treatment efficacy.
Pofelski
Joanna
J
Département d'Hépato-Gastroentérologie, CHU de Grenoble, Cedex. JPofelski@chu-grenoble.fr
Heluwaert
Frédéric
F
Roblin
Xavier
X
Morand
Patrice
P
Gratacap
Bénédicte
B
Germain
Emmanuel
E
Brion
Jean-Paul
JP
Salon
Caroline
C
Bonaz
Bruno
B
D000998:Antiviral Agents / Q000627:therapeutic use; D003587:Cytomegalovirus / Q000276:immunology; D003586:Cytomegalovirus Infections / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D007155:Immunologic Factors / Q000276:immunology; D015212:Inflammatory Bowel Diseases / Q000188:drug therapy / Q000821:virology*; D014779:Virus Replication / Q000502:physiology
D000998:Antiviral Agents; D007155:Immunologic Factors