title: Postoperative coagulopathy in a pediatric patient after exposure to bovine topical thrombin.
abstract: Severe postoperative coagulopathy developed in a child with congenital heart disease due to a factor V inhibitor from repetitive exposure to bovine topical thrombin. This case report alerts pediatric providers to consider these inhibitors when postoperative coagulopathy occurs. Potential treatment options are reviewed.
authors: Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota 55455, USA.
authors: Sheri S
authors: SS
authors: Crow
authors: Vita V
authors: VV
authors: Sullivan
authors: Agnes E
authors: AE
authors: Aysola
authors: Nigel S
authors: NS
authors: Key
authors: Paul
authors: P
authors: Harker-Murray
authors: John E
authors: JE
authors: Foker
authors: Marie E
authors: ME
authors: Steiner
mesh_terms: D000287:Administration, Topical; D000818:Animals; D001778:Blood Coagulation Disorders / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy; D016063:Blood Loss, Surgical / Q000517:prevention & control; D001803:Blood Transfusion; D006348:Cardiac Surgical Procedures / Q000009:adverse effects / Q000379:methods; D002417:Cattle; D005165:Factor V / Q000032:analysis*; D005260:Female; D005500:Follow-Up Studies; D006330:Heart Defects, Congenital / Q000175:diagnosis / Q000601:surgery; D006489:Hemostatic Techniques / Q000009:adverse effects; D006801:Humans; D007136:Immunoglobulins / Q000627:therapeutic use; D007223:Infant; D011183:Postoperative Complications / Q000175:diagnosis / Q000628:therapy; D018633:Pulmonary Atresia / Q000175:diagnosis / Q000601:surgery*; D018570:Risk Assessment; D013917:Thrombin / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D007136:Immunoglobulins; D005165:Factor V; D013917:Thrombin