Platinum complex as a nanomolar protein kinase inhibitor.
A pyridocarbazole platinum complex, which matches the overall shape of the natural product staurosporine, binds with high affinity at the adenosine triphosphate binding site of glycogen synthase kinase 3 (GSK-3alpha).
Williams
Douglas S
DS
Department of Chemistry, University of Pennsylvania, 231 S. 34th Street, Philadelphia, Pennsylvania 19104, USA.
Carroll
Patrick J
PJ
Meggers
Eric
E
D002227:Carbazoles / Q000737:chemistry*; D018360:Crystallography, X-Ray; D038362:Glycogen Synthase Kinase 3 / Q000037:antagonists & inhibitors* / Q000737:chemistry; D008958:Models, Molecular; D015394:Molecular Structure; D009944:Organoplatinum Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D047428:Protein Kinase Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D019311:Staurosporine / Q000737:chemistry; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D002227:Carbazoles; D009944:Organoplatinum Compounds; D047428:Protein Kinase Inhibitors; D038362:Glycogen Synthase Kinase 3; C448021:glycogen synthase kinase 3 alpha; D019311:Staurosporine