Toward a multiscale model of antigen presentation in immunity.
A functioning immune system and the process of antigen presentation in particular encompass events that occur at multiple length and time scales. Despite a wealth of information in the biological literature regarding each of these scales, no single representation synthesizing this information into a model of the overall immune response as it depends on antigen presentation is available. In this article, we outline an approach for integrating information over relevant biological and temporal scales to generate such a representation for major histocompatibility complex class II-mediated antigen presentation. In addition, we begin to address how such models can be used to answer questions about mechanisms of infection and new strategies for treatment and vaccines.
Kirschner
Denise E
DE
Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA. kirschne@umich.edu
Chang
Stewart T
ST
Riggs
Thomas W
TW
Perry
Nicolas
N
Linderman
Jennifer J
JJ
D000818:Animals; D017951:Antigen Presentation; D000938:Antigen-Presenting Cells / Q000276:immunology*; D000949:Histocompatibility Antigens Class II / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular; D018448:Models, Immunological
D000949:Histocompatibility Antigens Class II