title: Variation in blood levels of inflammatory markers related and unrelated to smoking cessation in women.
abstract: This study assessed the influence of short-term changes in smoking habit on blood levels of inflammatory markers, which have been associated with increased cardiovascular risk. Five inflammatory markers were measured before and 6 weeks after attempting smoking cessation in 138 healthy women. In the 48 participants who stopped smoking, white blood cell count (-0.7+/-1.2 x 10(9)/L; P<.001) and fibrinogen (-0.6+/-1.5 micromol/L; P<.01) decreased, but there was no significant (P>.1) change in the plasma level of C-reactive protein (median change +0.1; interquartile range -0.2, 0.9 mg/L), intercellular adhesion molecule 1 (+17+/-75 ng/mL), or CD40 ligand (+0.4+/-2.1 ng/mL). Most of the individual variation in inflammatory marker levels was unrelated to changes in smoking habit.
authors: Green Lane Cardiovascular Service, Auckland City Hospital, Auckland, New Zealand.
authors: Christopher J K
authors: CJ
authors: Hammett
authors: Harry
authors: H
authors: Prapavessis
authors: J Chris
authors: JC
authors: Baldi
authors: Rohan
authors: R
authors: Ameratunga
authors: Uwe
authors: U
authors: Schoenbeck
authors: Nerea
authors: N
authors: Varo
authors: John K
authors: JK
authors: French
authors: Harvey D
authors: HD
authors: White
authors: Ralph A H
authors: RA
authors: Stewart
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D023201:CD40 Ligand / Q000097:blood; D002318:Cardiovascular Diseases / Q000097:blood / Q000453:epidemiology; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D005500:Follow-Up Studies; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood; D007958:Leukocyte Count; D008875:Middle Aged; D016032:Randomized Controlled Trials as Topic; D012107:Research Design; D012307:Risk Factors; D012907:Smoking / Q000097:blood*; D016540:Smoking Cessation
chemical_list: D015415:Biomarkers; D018836:Inflammation Mediators; D018799:Intercellular Adhesion Molecule-1; D023201:CD40 Ligand; D005340:Fibrinogen; D002097:C-Reactive Protein