title: The prevention of pain from sickle cell disease by trandolapril.
abstract: A 48-year-old African-American woman with both sickle cell anemia and chronic pain was treated with a hydrophobic angiotensin I-converting enzyme (ACE) inhibitor. This resulted in the complete resolution of her pain. When the ACE inhibitor was deliberately stopped, her pain recurred, only to cease again after the ACE inhibitor was deliberately resumed. The activation of ACE may be an early step in the arterial vaso-occlusion typical of sickle cell disease.
authors: Stanislaus Cancer Treatment Research Foundation, Modesto, CA, USA.
authors: R Michael
authors: RM
authors: Williams
authors: David W
authors: DW
authors: Moskowitz
mesh_terms: D001741:Black or African American / Q000235:genetics; D000755:Anemia, Sickle Cell / Q000201:enzymology / Q000208:ethnology / Q000503:physiopathology*; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D015687:Cell Hypoxia / Q000187:drug effects; D002908:Chronic Disease; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007211:Indoles / Q000627:therapeutic use*; D008875:Middle Aged; D010146:Pain / Q000188:drug therapy* / Q000209:etiology; D007703:Peptidyl-Dipeptidase A / Q000235:genetics; D014661:Vasoconstriction / Q000187:drug effects
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D007211:Indoles; C052035:trandolapril; D007703:Peptidyl-Dipeptidase A