title: Global transcriptional response of Nitrosomonas europaea to chloroform and chloromethane.
abstract: Upon exposure of Nitrosomonas europaea to chloroform (7 microM, 1 h), transcripts for 175 of 2,460 genes were found at higher levels in treated cells than in untreated cells and transcripts for 501 genes were found at lower levels. With chloromethane (3.2 mM, 1 h), transcripts for 67 genes were at higher levels and transcripts for 148 genes were at lower levels. Transcripts for 37 genes were at higher levels following both treatments and included genes for heat shock proteins, sigma-factors of the extracytoplasmic function subfamily, and toxin-antitoxin loci. N. europaea has higher levels of transcripts for a variety of defense genes when exposed to chloroform or chloromethane.
authors: Department of Botany and Plant Pathology, Oregon State University, Corvallis, OR 97331, USA.
authors: Barbara O
authors: BO
authors: Gvakharia
authors: Elizabeth A
authors: EA
authors: Permina
authors: Mikhail S
authors: MS
authors: Gelfand
authors: Peter J
authors: PJ
authors: Bottomley
authors: Luis A
authors: LA
authors: Sayavedra-Soto
authors: Daniel J
authors: DJ
authors: Arp
mesh_terms: D000222:Adaptation, Physiological / Q000235:genetics; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001426:Bacterial Proteins / Q000235:genetics; D002725:Chloroform / Q000494:pharmacology*; D020869:Gene Expression Profiling; D015964:Gene Expression Regulation, Bacterial; D008737:Methyl Chloride / Q000494:pharmacology*; D043370:Nitrosomonas europaea / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism; D012329:RNA, Bacterial / Q000096:biosynthesis / Q000235:genetics; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D014158:Transcription, Genetic / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D012329:RNA, Bacterial; D012333:RNA, Messenger; D002725:Chloroform; D008737:Methyl Chloride