title: Genetic studies of GRN and IFT74 in amyotrophic lateral sclerosis.
abstract: There is increasing evidence of a clinical, neuropathological and genetic overlap between frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). We conducted a case-control study using a UK dataset to test the hypothesis that polymorphisms in two FTD-related genes (GRN and FT74) are associated with increased susceptibility to ALS. We evaluated the majority of known genetic variability in IFT74 and GRN. The results revealed that the common variations in IFT74 and GRN neither constitute strong ALS risk factors nor modify the age-at-onset. However, the possibility of a modest risk effect remains to be assessed in large datasets.
authors: Centre for Research in Neurodegenerative Diseases, Tanz Neuroscience Building, University of Toronto, 6 Queen's Park Crescent West, Toronto, Ontario, Canada M5S 3H2.
authors: Shangxi
authors: S
authors: Xiao
authors: Christine
authors: C
authors: Sato
authors: Toshitaka
authors: T
authors: Kawarai
authors: Emily F
authors: EF
authors: Goodall
authors: Hardev S
authors: HS
authors: Pall
authors: Lorne H
authors: LH
authors: Zinman
authors: Janice
authors: J
authors: Robertson
authors: Karen
authors: K
authors: Morrison
authors: Ekaterina
authors: E
authors: Rogaeva
mesh_terms: D000690:Amyotrophic Lateral Sclerosis / Q000453:epidemiology* / Q000235:genetics*; D016022:Case-Control Studies; D003598:Cytoskeletal Proteins / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics; D006801:Humans; D015994:Incidence; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics*; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D015995:Prevalence; D000077153:Progranulins; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D006113:United Kingdom / Q000453:epidemiology
chemical_list: D003598:Cytoskeletal Proteins; C492314:GRN protein, human; C490080:IFT74 protein, human; D036341:Intercellular Signaling Peptides and Proteins; D000077153:Progranulins