title: Identification of the L,D-transpeptidases responsible for attachment of the Braun lipoprotein to Escherichia coli peptidoglycan.
abstract: The L,D-transpeptidase Ldt(fm) catalyzes peptidoglycan cross-linking in beta-lactam-resistant mutant strains of Enterococcus faecium. Here, we show that in Escherichia coli Ldt(fm) homologues are responsible for the attachment of the Braun lipoprotein to murein, indicating that evolutionarily related domains have been tailored to use muropeptides or proteins as acyl acceptors in the L,D-transpeptidation reaction.
authors: INSERM, U655-LRMA, Université Pierre et Marie Curie, Centre de Recherches Biomédicales des Cordeliers, Paris, France. sophie.magnet@bhdc.jussieu.fr
authors: Sophie
authors: S
authors: Magnet
authors: Samuel
authors: S
authors: Bellais
authors: Lionel
authors: L
authors: Dubost
authors: Martine
authors: M
authors: Fourgeaud
authors: Jean-Luc
authors: JL
authors: Mainardi
authors: Sébastien
authors: S
authors: Petit-Frère
authors: Arul
authors: A
authors: Marie
authors: Dominique
authors: D
authors: Mengin-Lecreulx
authors: Michel
authors: M
authors: Arthur
authors: Laurent
authors: L
authors: Gutmann
mesh_terms: D000595:Amino Acid Sequence; D004926:Escherichia coli / Q000201:enzymology* / Q000235:genetics*; D029968:Escherichia coli Proteins / Q000235:genetics / Q000378:metabolism; D008074:Lipoproteins / Q000378:metabolism; D008969:Molecular Sequence Data; D010455:Peptides / Q000737:chemistry / Q000378:metabolism; D010457:Peptidoglycan / Q000378:metabolism; D010458:Peptidyl Transferases / Q000235:genetics / Q000378:metabolism*
chemical_list: D029968:Escherichia coli Proteins; D008074:Lipoproteins; D010455:Peptides; D010457:Peptidoglycan; D010458:Peptidyl Transferases