title: Acanthamoeba keratitis related to orthokeratology.
abstract: OBJECTIVE
  To report four cases of Acanthamoeba keratitis related to the overnight wearing of orthokeratology lenses.
  
  
  METHODS
  Four patients had histories of overnight wearing of orthokeratology lenses when they presented with corneal ulcers. They had used a contact lens care system irregularly with tap water.
  
  
  RESULTS
  The organism isolated by corneal scraping was Acanthamoeba. The patients were treated with polyhexamethylene biguanide (PHMB) and chlorhexidine, resulting in a resolution of ocular inflammation.
  
  
  CONCLUSIONS
  The risk of Acanthamoeba keratitis as a potential complication of overnight orthokeratology should be considered, especially in patients with over one-year duration of contact lens wearing. Careful contact lens management is needed and tap-water rinsing should be eliminated from the lens care regimen.
authors: Department of Ophthalmology, College of Medicine, Pusan National University, 1-10, Ami-Dong, Seo-Ku, Pusan 602-739, Korea.
authors: Ji-Eun
authors: JE
authors: Lee
authors: Tae Won
authors: TW
authors: Hahn
authors: Boo Sup
authors: BS
authors: Oum
authors: Hee Young
authors: HY
authors: Choi
authors: Hak Sun
authors: HS
authors: Yu
authors: Jong Soo
authors: JS
authors: Lee
mesh_terms: D015823:Acanthamoeba Keratitis / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D000293:Adolescent; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use; D001645:Biguanides / Q000627:therapeutic use; D002710:Chlorhexidine / Q000627:therapeutic use; D002940:Circadian Rhythm; D003261:Contact Lenses / Q000009:adverse effects*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D014792:Visual Acuity
chemical_list: D000891:Anti-Infective Agents, Local; D001645:Biguanides; C031233:polihexanide; D002710:Chlorhexidine