title: [Synthesis of N-acetyllactosamine-containing oligosaccharides, galectin ligands].
abstract: The following spacered oligosaccharides were synthesized: GlcNAcbetal-3Galbetal-4GlcNAcbeta-sp, GlcNAcbetal-6Galbeta1-4GlcNAcbeta -sp, GlcNAcbeta -3(GlcNAcbeta1-6)Galbeta-4GllcNAcbeta-sp, Galbeta1-4GlcNAcbeta1-3Galbeta1-4GlcNAcbeta-sp, Galbeta1-4GlcNAcbetal-6Galbetal-4GlcNAcbeta-sp, Galbeta1-4GlcNAcbeta -3(Galbeta1-4GlcNAcbeta 1-6)Galbeta1-4GlcNAcbeta-sp, GlcNAcbeta1-3(Galbeta1-4GlcNAcbetal-6)Galbeta 1-4GlcNAcbeta-sp, and Galbeta1-4GlcNAcbetal-3(GlcNAcbetal-6)Galbetal-4GlcNAcbeta-sp (sp = O(CH2)2NH2). They represent N-acetyllactosamines substituted with N-acetylgly-cosamine or N-acetyllalctosamine residue at 03, O6, or at both positions of galactose. Glycosylation was achieved by coupling with N-trichloroethoxycarbonyl-protected glucosamine bromide in the presence of silver triflate.
authors: V V
authors: VV
authors: Severov
authors: I M
authors: IM
authors: Belianchikov
authors: G V
authors: GV
authors: Pazynina
authors: N V
authors: NV
authors: Bovin
mesh_terms: D000606:Amino Sugars / Q000032:analysis*; D002240:Carbohydrate Sequence; D037161:Galectins / Q000737:chemistry*; D008024:Ligands; D008969:Molecular Sequence Data; D009844:Oligosaccharides / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D000606:Amino Sugars; D037161:Galectins; D008024:Ligands; D009844:Oligosaccharides; C000458:N-acetyllactosamine