title: Low plasma levels of the protein pro-LL-37 as an early indication of severe disease in patients with chronic neutropenia.
abstract: Chronic neutropenia comprises several different diseases that vary in degree of severity and management. We analysed the levels of the neutrophil-derived protein pro-LL-37 in plasma of patients with chronic neutropenia to assess whether it could be used to differentiate different categories of chronic neutropenia. All patients with severe congenital neutropenia were pro-LL-37 deficient. This was in contrast to patients with autoimmune or idiopathic neutropenia, who exhibited normal pro-LL-37 levels while patients with cyclic neutropenia displayed an oscillation of pro-LL-37 in plasma. Plasma levels of pro-LL-37 may thus prove useful for differential diagnosis of chronic neutropenia.
authors: Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
authors: Jenny
authors: J
authors: Karlsson
authors: Göran
authors: G
authors: Carlsson
authors: Kim Göransdotter
authors: KG
authors: Ramme
authors: Hans
authors: H
authors: Hägglund
authors: Bengt
authors: B
authors: Fadeel
authors: Magnus
authors: M
authors: Nordenskjöld
authors: Jan-Inge
authors: JI
authors: Henter
authors: Jan
authors: J
authors: Palmblad
authors: Katrin
authors: K
authors: Pütsep
authors: Mats
authors: M
authors: Andersson
mesh_terms: D000293:Adolescent; D000328:Adult; D023181:Antimicrobial Cationic Peptides / Q000097:blood* / Q000172:deficiency; D001327:Autoimmune Diseases / Q000097:blood / Q000175:diagnosis; D015415:Biomarkers / Q000097:blood; D054804:Cathelicidins; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D003937:Diagnosis, Differential; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D006801:Humans; D015151:Immunoblotting; D019272:Leukocyte Elastase / Q000235:genetics; D008297:Male; D009154:Mutation; D009503:Neutropenia / Q000151:congenital / Q000209:etiology* / Q000235:genetics
chemical_list: D023181:Antimicrobial Cationic Peptides; D015415:Biomarkers; D054804:Cathelicidins; D019272:Leukocyte Elastase