title: One-pot, multicomponent route to pyrazoloquinolizinones.
abstract: [reaction: see text] An efficient synthesis of 5a-hydroxy-4,5,5a,6,7,8-hexahydropyrazolo[4,3-c]quinolizin-9-ones based on the three-component condensation of 5-aminopyrazoles, aromatic aldehydes, and cyclic 1,3-diketones is described. The multicomponent reaction is performed under strongly basic conditions applying controlled microwave heating in a sealed vessel and involves an unusual base-mediated ring-opening/recyclization of the cyclic 1,3-diketone moiety.
authors: State Scientific Institution "Institute for Single Crystals" of the National Academy of Sciences of Ukraine, Lenin Ave, Kharkiv, Ukraine.
authors: Valentin A
authors: VA
authors: Chebanov
authors: Vyacheslav E
authors: VE
authors: Saraev
authors: Sergey M
authors: SM
authors: Desenko
authors: Vitaliy N
authors: VN
authors: Chernenko
authors: Svetlana V
authors: SV
authors: Shishkina
authors: Oleg V
authors: OV
authors: Shishkin
authors: Kiril M
authors: KM
authors: Kobzar
authors: C Oliver
authors: CO
authors: Kappe
mesh_terms: D018360:Crystallography, X-Ray; D006900:Hydroxylation; D008958:Models, Molecular; D015394:Molecular Structure; D011807:Quinolizines / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D011807:Quinolizines