Secondary metabolite chemistry of the marine-derived fungus Massarina sp., strain CNT-016.
Chemical investigation of the culture broth extracts of the marine-derived fungus Massarina sp. (strain CNT-016) has yielded two secondary metabolites, spiromassaritone (1) and massariphenone (2), as well as the previously reported fungal metabolites 6-epi-5'-hydroxy-mycosporulone (3) and enalin A (4). The structures of these compounds were established by a variety of one- and two-dimensional NMR experiments, while the relative configuration of spiromassaritone (1) was determined by X-ray crystallographic methods. The fungal strain was isolated as a sterile mycelium from an ocean mud sample and identified using ITS sequence analysis.
Abdel-Wahab
Mohamed A
MA
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92093-0204, USA.
Asolkar
Ratnakar N
RN
Inderbitzin
Patrik
P
Fenical
William
W
D001203:Ascomycota / Q000145:classification / Q000378:metabolism*; D001555:Benzene Derivatives / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism; D018360:Crystallography, X-Ray; D003512:Cyclohexanones / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism; D007659:Ketones / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism; D008958:Models, Molecular; D019906:Nuclear Magnetic Resonance, Biomolecular; D010636:Phenols / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism; D010802:Phylogeny; D013141:Spiro Compounds
C521874:6-epi-5'-hydroxy-mycosporulone; D001555:Benzene Derivatives; D003512:Cyclohexanones; D007659:Ketones; D010636:Phenols; D013141:Spiro Compounds; C454600:enalin A; C521873:massariphenone; C521872:spiromassaritone