title: SAR studies on thiazolo[4,5-d]pyrimidine based CXCR2 antagonists involving a novel tandem displacement reaction.
abstract: As part of a Lead Optimisation programme to identify small molecule antagonists of the human CXCR2 receptor, a series of substituted thiazolo[4,5-d]pyrimidines was prepared via the application of a novel tandem displacement reaction.
authors: AstraZeneca R&D Charnwood, Bakewell Road, Loughborough LE11 5RH, UK. FRASER.HUNT@ASTRAZENECA.COM
authors: Fraser
authors: F
authors: Hunt
authors: Caroline
authors: C
authors: Austin
authors: Rupert
authors: R
authors: Austin
authors: Roger
authors: R
authors: Bonnert
authors: Peter
authors: P
authors: Cage
authors: Jadeen
authors: J
authors: Christie
authors: Mark
authors: M
authors: Christie
authors: Clare
authors: C
authors: Dixon
authors: Steven
authors: S
authors: Hill
authors: Robert
authors: R
authors: Jewell
authors: Ian
authors: I
authors: Martin
authors: David
authors: D
authors: Robinson
authors: Paul
authors: P
authors: Willis
mesh_terms: D000818:Animals; D006801:Humans; D051381:Rats; D018121:Receptors, Cytokine / Q000037:antagonists & inhibitors; D023063:Receptors, Interleukin-8B / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D018121:Receptors, Cytokine; D023063:Receptors, Interleukin-8B; D013844:Thiazoles; C039201:thiazolo(3,2-a)perimidine