miRNA editing--we should have inosine this coming.
In a recent issue of Science, Nishikura and colleagues provide the first evidence that editing of a microRNA (miRNA) precursor by ADARs can modulate the target specificity of the mature miRNA (Kawahara et al., 2007).
Habig
Jeffrey W
JW
Department of Biochemistry, University of Utah, Salt Lake City, UT 84112, USA; Howard Hughes Medical Institute, University of Utah, Salt Lake City, UT 84112, USA.
Dale
Taraka
T
Bass
Brenda L
BL
D000818:Animals; D006801:Humans; D007288:Inosine / Q000378:metabolism*; D007438:Introns; D035683:MicroRNAs / Q000235:genetics*; D017393:RNA Editing / Q000235:genetics*; D034622:RNA Interference; D012330:RNA, Double-Stranded / Q000378:metabolism; D034741:RNA, Small Interfering / Q000235:genetics
D035683:MicroRNAs; D012330:RNA, Double-Stranded; D034741:RNA, Small Interfering; D007288:Inosine