Influences of reduced masticatory sensory input from soft-diet feeding upon spatial memory/learning ability in mice.
It has been reported that reduction of masticatory afferent stimulation might influence learning and memory function. In order to clarify the influences of reduced masticatory sensory input on spatial memory/learning ability and neuropathological changes, we conducted the Morris water maze experiment and investigated the number of hippocampal neurons in association with the differences in masticatory afferent stimuli from hard- and soft-diet feeding in mice. The water maze experiment showed no significant difference in learning ability between 180-day-old solid- and powderdiet groups. Meanwhile, the ability was significantly reduced in the 360-day-old powder-diet group as compared with the age-matched solid-diet group. The total number of pyramidal cells in the hippocampal CA1 and CA3 regions was significantly smaller in 360-day-old powder-diet group than in the remaining groups. These results demonstrate that reduction of masticatory afferent stimuli due to long-term soft-diet feeding may induce neuron loss in the hippocampus and reduced memory/learning ability.
Tsutsui
Keisuke
K
Department of Orthodontics and Craniofacial Developmental Biology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan. kktt0821@hotmail.com
Kaku
Masato
M
Motokawa
Masahide
M
Tohma
Yuiko
Y
Kawata
Toshitsugu
T
Fujita
Tadashi
T
Kohno
Shinya
S
Ohtani
Junji
J
Tenjoh
Kaoru
K
Nakano
Mao
M
Kamada
Hiroko
H
Tanne
Kazuo
K
D000818:Animals; D006624:Hippocampus / Q000166:cytology / Q000502:physiology; D007858:Learning / Q000502:physiology*; D008297:Male; D008409:Mastication / Q000502:physiology*; D008568:Memory / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D014110:Touch / Q000502:physiology*