title: Daily blood pressure control is not sufficient to regress cardiac hypertrophy and dysfunction: a bi-ventricular tissue Doppler echocardiographic study.
abstract: BACKGROUND
  Hypertension is one of the main causes of cardiovascular complications leading to death and allograft dysfunction. The aim of this study was to determine the relationship between the levels of 24 h blood pressure and left ventricular mass index (LVMI) and bi-ventricular tissue Doppler echocardiographic measurements in renal transplant recipients (RTxr) and dialysis patients.
  
  
  METHODS
  In this cross-sectional study, we evaluated 32 non-diabetic renal transplant recipients (GI) and 18 patients with end-stage renal insufficiency who underwent haemodialysis (GII).
  
  
  RESULTS
  The mean follow-up periods were 49.16 +/- 38.02 and 56.83 +/- 34.14 months in GI and GII, respectively. There were no differences for age, gender, daytime systolic-diastolic blood pressures and loads among the groups. The mean night-time systolic-diastolic blood pressures in GI and GII were 119.77 +/- 17.41-77.34 +/- 14.46 and 120.23 +/- 25.53-76.17 +/- 18.77 mmHg, respectively (P I-II = 0.453-0.72). The mean night-time systolic blood pressure loads in GI and GII were 4.92 +/- 7.77 and 6.10 +/- 8.16%, respectively (P I-II = 0.68). The mean night-time diastolic blood pressure loads were 7.79 +/- 7.83 and 8.02 +/- 8.28% in GI and GII, respectively (P I-II = 0.55). The mean levels of LVMI in GI and GII were 115.81 +/- 28.07 and 128.06 +/- 65.72 g/m(2), respectively (P I-II = 0.85). The mean levels of left ventricular Em/Am by tissue Doppler echocardiography were 1.13 +/- 0.40 and 0.90 +/- 0.29, respectively (P I-II = 0.127), while the mean levels of right ventricular Em/Am were 0.89 +/- 0.37 and 0.88 +/- 0.26, respectively (P I-II = 0.50).
  
  
  CONCLUSIONS
  After renal transplantation, LVMI and bi-ventricular diastolic dysfunction were not regressed. Daytime and night-time blood pressures and loads were similar in the two groups. We can say that well-controlled daytime blood pressure and load is not sufficient to decrease cardiovascular risk in RTxr. Also, it is important to control of night-time blood pressure and load to reduce cardiovascular risk in RTxr. RTxr should be monitored with ambulatory blood pressure monitoring and tissue Doppler echocardiography.
authors: Division of Nephrology, Department of Internal Medicine, School of Medicine, Cukurova University, Balcali-Adana, Turkey.
authors: Mustafa
authors: M
authors: Balal
authors: Mevlut
authors: M
authors: Koc
authors: Saime
authors: S
authors: Paydas
authors: Erkan
authors: E
authors: Demir
authors: Yasar
authors: Y
authors: Sertdemir
authors: Esmeray
authors: E
authors: Acarturk
mesh_terms: D000328:Adult; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects; D018660:Blood Pressure Monitoring, Ambulatory; D002940:Circadian Rhythm; D003430:Cross-Sectional Studies; D015150:Echocardiography, Doppler; D005260:Female; D005500:Follow-Up Studies; D006352:Heart Ventricles / Q000000981:diagnostic imaging; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology*; D017379:Hypertrophy, Left Ventricular / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis / Q000009:adverse effects*; D013997:Time Factors; D016276:Ventricular Function
chemical_list: D000959:Antihypertensive Agents