title: [Study of prophylactic intra-iliac and hepatic arterial infusion chemotherapy against pelvic recurrence and liver metastasis after radical resection for rectal cancer].
abstract: OBJECTIVE
  To study the effects of prophylactic intra-iliac and hepatic arterial infusion chemotherapy on pelvic recurrence and liver metastasis after radical resection for rectal cancer.
  
  
  METHODS
  Eighty-four rectal cancer patients,undergone radical resection on Dukes stage B or C,were randomly assigned to postoperative intra-iliac and hepatic arterial infusion chemotherapy group(group I) and routine vein chemotherapy group(group II). Five-year survival and recurrence rates were compared between the two groups.
  
  
  RESULTS
  Among the 84 rectal cancer patients with radical resection, the 5-year liver metastasis and pelvic recurrence rates were 30.2% (13/43) and 18.6% (8/43) respectively in group II, 17.1% (7/41) and 9.8% (4/41) in group I, the difference was significant between 2 groups (chi(2)=4.31, P<0.05). The mean tumor-free survival time was 26.2 months in group I and 15.8 months in group II (t=5.05, P<0.01), the difference was significant (t=5.05, P<0.01). The five-year survival rate in group I (65.9%) was significantly higher than that in group II (56.5%) (u=8.86, P<0.01). Cox multivariate analysis showed that, compared with those in group II, the relative risks of pelvic recurrence and liver metastasis in group I decreased 20% (coefficient of relative risk: 0.7959), and the five-year mortality also decreased 20% (coefficient of relative risk: 0.8034).
  
  
  CONCLUSIONS
  Prophylactic intra-iliac and hepatic arterial infusion chemotherapy can reduce the rates of pelvic recurrence and liver metastasis after radical resection of rectal cancer.
authors: Department of General Surgery, Zhejiang Provincial Peopleçs Hospital, Hangzhou 310014, China. tushiliang@126.com
authors: Shi-liang
authors: SL
authors: Tu
authors: Jian-hua
authors: JH
authors: Yuan
authors: Gao-li
authors: GL
authors: Deng
authors: Zhong-sheng
authors: ZS
authors: Zhao
authors: Ting-yang
authors: TY
authors: Hu
authors: Quan-jin
authors: QJ
authors: Dong
authors: Hong-feng
authors: HF
authors: Cao
authors: Zai-yuan
authors: ZY
authors: Ye
mesh_terms: D000328:Adult; D017024:Chemotherapy, Adjuvant; D010478:Chemotherapy, Cancer, Regional Perfusion; D005260:Female; D006499:Hepatic Artery; D006801:Humans; D007083:Iliac Artery; D008113:Liver Neoplasms / Q000517:prevention & control / Q000556:secondary; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control; D010386:Pelvic Neoplasms / Q000517:prevention & control / Q000556:secondary; D010388:Pelvis / Q000473:pathology; D012004:Rectal Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D015996:Survival Rate