PHLPPing it off: phosphatases get in the Akt.
Three Akt isoforms differentially control cell survival, growth, proliferation, metabolism, and motility. In this issue of Molecular Cell, Brognard et al. (2007) report that two PHLPP phosphatases specifically downregulate the Akts to control the activity of isoform-specific substrates.
Mendoza
Michelle C
MC
Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA.
Blenis
John
J
D003924:Diabetes Mellitus, Type 2 / Q000201:enzymology; D004789:Enzyme Activation; D006801:Humans; D009369:Neoplasms / Q000201:enzymology; D010641:Phenotype; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism*; D011494:Protein Kinases / Q000378:metabolism*; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism*; D013379:Substrate Specificity; D058570:TOR Serine-Threonine Kinases
D019869:Phosphatidylinositol 3-Kinases; D011494:Protein Kinases; D051057:Proto-Oncogene Proteins c-akt; D058570:TOR Serine-Threonine Kinases; C546842:MTOR protein, human