Outcomes of tuberculosis patients who start antiretroviral therapy under routine programme conditions in Malawi.
METHODS
Public sector facilities in Malawi providing antiretroviral therapy (ART) to human immunodeficiency virus (HIV) positive patients, including those with tuberculosis (TB).


OBJECTIVE
To compare 6-month and 12-month cohort treatment outcomes of HIV-positive TB patients and HIV-positive non-TB patients treated with ART.


METHODS
Retrospective data collection using ART patient master cards and ART patient registers.


RESULTS
Between July and September 2005, 7905 patients started ART, 6967 with a non-TB diagnosis and 938 with a diagnosis of active TB. 6-month cohort outcomes of non-TB and TB patients censored on 31 March 2006 showed significantly more TB patients alive and on ART (77%) compared with non-TB patients (71%) (P < 0.001). Between January and March 2005, 4580 patients started ART, 4179 with a non-TB diagnosis and 401 with a diagnosis of active TB. 12-month cohort outcomes of non-TB and TB patients censored on 31 March 2006 showed significantly more TB patients alive and on ART (74%) compared with non-TB patients (66%) (P < 0.001). Other outcomes of default and transfer out were also significantly less frequent in TB compared with non-TB patients.


CONCLUSIONS
HIV-positive TB patients on ART in Malawi have generally good treatment outcomes, and more patients need to access this HIV treatment.
Makombe
S D
SD
Clinical HIV Unit, Ministry of Health, Lilongwe 3, Malawi.
Harries
A D
AD
Yu
J K-L
JK
Hochgesang
M
M
Mhango
E
E
Weigel
R
R
Pasulani
O
O
Fitzgerald
M
M
Schouten
E J
EJ
Libamba
E
E
D044966:Anti-Retroviral Agents / Q000627:therapeutic use*; D015897:Comorbidity; D015658:HIV Infections / Q000188:drug therapy* / Q000453:epidemiology*; D006801:Humans; D008295:Malawi / Q000453:epidemiology; D016896:Treatment Outcome; D014376:Tuberculosis / Q000453:epidemiology*
D044966:Anti-Retroviral Agents