Mature T-cell leukemias including T-prolymphocytic leukemia, adult T-cell leukemia/lymphoma, and Sézary syndrome.
The 2005 Society for Hematopathology/European Association for Haematopathology Workshop Session 1 was devoted to case presentations with discussions of 3 types of mature T-cell leukemias--T-cell prolymphocytic leukemia, adult T-cell leukemia/lymphoma, and Sézary syndrome. These 3 disorders are clonal proliferations of postthymic alphabeta T cells that are often characterized by systemic manifestations and a leukemic blood picture. The application of clinical, morphologic, immunophenotypic, and genetic studies to the assessment and characterization of these 3 disorders is presented, along with specific diagnostic recommendations and differential diagnostic considerations.
Foucar
Kathryn
K
The Department of Pathology, University of New Mexico Health Sciences Center, Albuquerque, NM 87102-2705, USA.
D015703:Antigens, CD / Q000378:metabolism; D002869:Chromosome Aberrations; D003937:Diagnosis, Differential; D006801:Humans; D016130:Immunophenotyping; D015463:Leukemia, Prolymphocytic / Q000175:diagnosis* / Q000235:genetics; D015458:Leukemia, T-Cell / Q000175:diagnosis* / Q000235:genetics; D012751:Sezary Syndrome / Q000175:diagnosis* / Q000235:genetics; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000235:genetics
D015703:Antigens, CD