[Expression and significance of hypoxia inducible factor-1alpha in buccal carcinoma].
OBJECTIVE
To study the expression of hypoxia inducible factor-1alpha (HIF-1alpha) protein in buccal carcinoma and its biological significance.


METHODS
The expression of HIF-1alpha was assayed by means of immunohistochemical technique in 60 patients. The expression of HIF-1alpha and its relationship with clinical pathological factors and tumor prognosis were investigated and analyzed statistically by Kruskal-Wallis Test.


RESULTS
The positive rate of HIF-1alpha was higher in T3-4 than T1-2, and the positive rate of HIF-1alpha was higher in patients with cervical lymphatic metastasis than patients without cervical lymphatic metastasis. Patients with HIF-1alpha over-expression had poor prognosis than patients with HIF-1alpha lower expression.


CONCLUSIONS
Over-expression of HIF-1alpha is a vital biological marker in prognosis of buccal cancer.
Han
Bo
B
Dept. of Head and Neck Tumor Surgery, West China College of Stomatology, Sichuan University, Chengdu, China.
Li
Long-jiang
LJ
Dai
Wei
W
D000368:Aged; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009062:Mouth Neoplasms; D011379:Prognosis
D051795:Hypoxia-Inducible Factor 1, alpha Subunit