Inhibitory effects of histone deacetylase inhibitor depsipeptide on benzo(a)pyrene- and cyclophosphamide-induced genotoxicity in Swiss albino mice.
Depsipeptide (FK228 or FR901228) was evaluated in the mouse bone marrow micronucleus test for its possible protective effect against chromosomal damage induced by benzo(a)pyrene and cyclophosphamide. Three doses of depsipeptide (0.5, 1, and 1.5 mg/kg body weight) were given intravenously to mice for 7 consecutive days prior to administration of genotoxins under investigation. All the three doses of depsipeptide were effective in exerting a protective effect against both benzo(a)pyrene and cyclophosphamide. A significant suppression (34.9% to 67.5%) in the micronuclei formation induced by benzo(a)pyrene and (25.7% to 71.5%) cyclophosphamide was observed following intravenous administration of depsipeptide at doses of 0.5, 1, and 1.5 mg/kg in Swiss albino mice.
Radhakrishnan
Vinodhkumar
V
Department of Biochemistry, University of Madras, Guindy Campus, Chennai, India.
Vinodhkumar
Radhakrishnan
R
Kumar
Radhakrishnan Vinodh
RV
Park
Chung Mu
CM
Mu
Park Chung
PC
Ravikumar
Vilwanathan
V
Devaki
Thiruvengadam
T
D000818:Animals; D016587:Antimutagenic Agents / Q000494:pharmacology*; D001564:Benzo(a)pyrene; D002861:Chromobacterium / Q000737:chemistry; D003520:Cyclophosphamide; D004249:DNA Damage; D047630:Depsipeptides / Q000494:pharmacology*; D056572:Histone Deacetylase Inhibitors; D008297:Male; D051379:Mice; D015162:Micronucleus Tests
D016587:Antimutagenic Agents; D047630:Depsipeptides; D056572:Histone Deacetylase Inhibitors; D001564:Benzo(a)pyrene; D003520:Cyclophosphamide