title: Colonic lymphoid nodular hyperplasia in children: relationship to food hypersensitivity.
abstract: OBJECTIVE
  The clinical significance of lymphoid nodular hyperplasia (LNH) of the lower gastrointestinal tract is unclear. The aim of this study was to define the frequency and clinical significance of LNH in pediatric patients undergoing colonoscopy.
  
  
  METHODS
  Two hundred forty-five children (101 male, 144 female; median age, 8.5 years) for whom colonoscopy had been indicated were evaluated during a 3-year period. Apart from ileocolonoscopy with biopsy, all patients underwent routine biochemistry, serum total and specific IgE, and/or skin prick tests for food allergens. Patients with LNH underwent elimination diet and subsequent food challenges.
  
  
  RESULTS
  LNH was observed in 73 of 245 (30%) consecutive colonoscopies. LNH was the only abnormal finding in 52 of the 73 cases (71%). In 43 of these 52 patients a diagnosis of cow's milk or multiple food hypersensitivity was made. Food allergy was significantly more common than in patients without LNH (83% vs 31%; P < .0001). The patients with LNH and food hypersensitivity presented hematochezia (P < .0001), elevated serum anti-beta-lactoglobulin IgG (P < .0001), anemia (P < .005), and failure to thrive (P < .03) more frequently than those without LNH. In the LNH patients histologic examination showed a higher number of lymphoid follicles throughout the colon and the terminal ileum and an increased number of lamina propria and intraepithelial eosinophils.
  
  
  CONCLUSIONS
  The presence of LNH in the colon and/or terminal ileum is a frequent finding in symptomatic children undergoing colonoscopy. Unless associated with other specific endoscopic or histologic lesions, LNH is related to a condition of delayed-type food hypersensitivity.
authors: Division of Pediatric Gastroenterology, Di Cristina Children's Hospital, Palermo, Italy.
authors: Giuseppe
authors: G
authors: Iacono
authors: Alberto
authors: A
authors: Ravelli
authors: Lidia
authors: L
authors: Di Prima
authors: Calogero
authors: C
authors: Scalici
authors: Stefania
authors: S
authors: Bolognini
authors: Sara
authors: S
authors: Chiappa
authors: Giuseppe
authors: G
authors: Pirrone
authors: Giuseppina
authors: G
authors: Licastri
authors: Antonio
authors: A
authors: Carroccio
mesh_terms: D000293:Adolescent; D017677:Age Distribution; D001707:Biopsy, Needle; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D003108:Colonic Diseases / Q000453:epidemiology* / Q000473:pathology*; D003113:Colonoscopy / Q000379:methods; D005260:Female; D005512:Food Hypersensitivity / Q000175:diagnosis* / Q000453:epidemiology*; D006801:Humans; D006965:Hyperplasia / Q000473:pathology; D007150:Immunohistochemistry; D007223:Infant; D007413:Intestinal Mucosa / Q000473:pathology; D008206:Lymphatic Diseases / Q000453:epidemiology* / Q000473:pathology*; D008297:Male; D015995:Prevalence; D011336:Probability; D011379:Prognosis; D012189:Retrospective Studies; D012720:Severity of Illness Index; D017678:Sex Distribution