title: Distal charge transport in peptides.
abstract: Biological systems often transport charges and reactive processes over substantial distances. Traditional models of chemical kinetics generally do not describe such extreme distal processes. In this Review, an atomistic model for a distal transport of information, which was specifically developed for peptides, is considered. Chemical reactivity is taken as the result of distal effects based on two-step bifunctional kinetics involving unique, very rapid motional properties of peptides in the subpicosecond regime. The bifunctional model suggests highly efficient transport of charge and reactivity in an isolated peptide over a substantial distance; conversely, a very low efficiency in a water environment was found. The model suggests ultrafast transport of charge and reactivity over substantial molecular distances in a peptide environment. Many such domains can be active in a protein.
authors: Institut für Physikalische und Theoretische Chemie, Technische Universität München, Lichtenbergstrasse 4, 85748 Garching, Germany. schlag@mytum.de
authors: Edward W
authors: EW
authors: Schlag
authors: Sheh-Yi
authors: SY
authors: Sheu
authors: Dah-Yen
authors: DY
authors: Yang
authors: Heinrich L
authors: HL
authors: Selzle
authors: Sheng Hsien
authors: SH
authors: Lin
mesh_terms: D000465:Algorithms; D000596:Amino Acids / Q000737:chemistry / Q000378:metabolism; D001692:Biological Transport; D002462:Cell Membrane / Q000737:chemistry / Q000378:metabolism; D007477:Ions / Q000737:chemistry*; D007700:Kinetics; D013058:Mass Spectrometry; D008564:Membrane Potentials; D008958:Models, Molecular; D010455:Peptides / Q000737:chemistry* / Q000378:metabolism; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism
chemical_list: D000596:Amino Acids; D007477:Ions; D010455:Peptides; D011506:Proteins