title: Relationship between regional and global left ventricular systolic and diastolic function in patients with coronary artery disease assessed by strain rate imaging.
abstract: BACKGROUND
  The relationship between regional and global left ventricular function has not been evaluated. The present study aimed to assess whether regional myocardial contraction and relaxation reflect global left ventricular systolic and early diastolic function, respectively.
  
  
  RESULTS
  The study involved 45 patients with coronary artery disease (CAD). Conventional echocardiography was performed, and segmental peak strain rate (SR) in the systole (S(SR)) and early diastole (E(SR)) were obtained from tissue Doppler imaging in each of 18 segments of the left ventricular myocardium from the apical views. The E(SR) was significantly correlated with S(SR) in all studied segments (r=0.55, p<0.0001). The average values of SR indices in each patient were defined as S(SR) index and E(SR) index, which were derived by dividing the summed value of the S(SR) or E(SR) by the number of respective assessable segments. A significant positive relationship was observed between the S(SR) index and left ventricular ejection fraction (r=0.85, p<0.0001). Also, there was a positive correlation between the E(SR) index and mitral flow E (r=0.68, p<0.0001).
  
  
  CONCLUSIONS
  Regional myocardial contraction and relaxation, as assessed by SR imaging, were closely related in patients with CAD. Furthermore, regional myocardial contraction and relaxation are important factors affecting global left ventricular systolic and early diastolic function.
authors: Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
authors: Hidekazu
authors: H
authors: Tanaka
authors: Hiroya
authors: H
authors: Kawai
authors: Kazuhiro
authors: K
authors: Tatsumi
authors: Toshiya
authors: T
authors: Kataoka
authors: Tetsuari
authors: T
authors: Onishi
authors: Takahisa
authors: T
authors: Nose
authors: Takahiro
authors: T
authors: Mizoguchi
authors: Mitsuhiro
authors: M
authors: Yokoyama
mesh_terms: D000368:Aged; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000503:physiopathology*; D003971:Diastole / Q000502:physiology*; D015150:Echocardiography, Doppler / Q000379:methods*; D005260:Female; D006321:Heart / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000502:physiology; D013318:Stroke Volume / Q000502:physiology; D013599:Systole / Q000502:physiology*; D018487:Ventricular Dysfunction, Left / Q000503:physiopathology*