title: Skeletal muscle fatty acid transporter protein expression in type 2 diabetes patients compared with overweight, sedentary men and age-matched, endurance-trained cyclists.
abstract: OBJECTIVE
  Membrane fatty acid transporters can modulate the balance between fatty acid uptake and subsequent storage and/or oxidation in muscle tissue. As such, skeletal muscle fatty acid transporter protein expression could play an important role in the etiology of insulin resistance and/or type 2 diabetes.
  
  
  METHODS
  In the present study, fatty acid translocase (FAT/CD36), plasma membrane-bound fatty acid-binding protein (FABPpm) and fatty acid transport protein 1 (FATP1) mRNA and protein expression were assessed in muscle tissue obtained from 10 sedentary, overweight type 2 diabetes patients (60 +/- 2 years), 10 sedentary, weight-matched normoglycemic controls (60 +/- 2 years) and 10 age-matched, endurance trained cyclists (57 +/- 1 years).
  
  
  RESULTS
  Both FAT/CD36 and FATP1 mRNA and protein expression did not differ between groups. In contrast, FABPpm mRNA and protein expression were approx. 30-40% higher in the trained men compared with the diabetes patients (P < 0.01) and sedentary controls (P < 0.05).
  
  
  CONCLUSIONS
  Skeletal muscle FAT/CD36, FABPpm and FATP1 mRNA and protein expression are not up- or downregulated in a sedentary and/or insulin resistant state. In contrast, FABPpm expression is upregulated in the endurance trained state and likely instrumental to allow greater fatty acid oxidation rates.
authors: Department of Movement Sciences, Maastricht University, Maastricht, The Netherlands. maurice.pelsers@bw.unimaas.nl
authors: M M A L
authors: MM
authors: Pelsers
authors: K
authors: K
authors: Tsintzas
authors: H
authors: H
authors: Boon
authors: K
authors: K
authors: Jewell
authors: L
authors: L
authors: Norton
authors: J J F P
authors: JJ
authors: Luiken
authors: J F C
authors: JF
authors: Glatz
authors: L J C
authors: LJ
authors: van Loon
mesh_terms: D001642:Bicycling / Q000502:physiology; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics / Q000378:metabolism*; D050612:Fatty Acid Transport Proteins / Q000235:genetics* / Q000378:metabolism*; D005786:Gene Expression Regulation; D006801:Humans; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000378:metabolism*; D050177:Overweight / Q000235:genetics / Q000378:metabolism*; D010807:Physical Endurance / Q000502:physiology*
chemical_list: D050612:Fatty Acid Transport Proteins