[The correlation of polymorphism of estrogen receptor gene to dry eye syndrome in postmenopausal women].
OBJECTIVE
To investigate the correlation of estrogen receptor (ER) gene polymorphism to dry eye syndrome in postmenopausal women.


METHODS
Xba I and Pvu II polymorphism of ER gene were studied by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 65 patients with dry eye syndrome and 73 with controls in postmenopausal women.


RESULTS
There was a significant difference of Pvu II polymorphism of ER gene between the patients of dry eye syndrome and controls in postmenopausal women (P < 0.05), but no significant difference was found in Xba I polymorphism of ER gene (P > 0.05).


CONCLUSIONS
There is a significant correlation of Pvu II polymorphism of ER gene with dry eye syndrome in postmenopausal women. It is indicated that the difference in ER genotypes might influence the development of dry eye syndrome.
He
Yanling
Y
Department of Ophthalmology, People's Hospital, Beijing University, Beijing 100044 China. heyanling2002@sohu.com
Li
Xiaoxin
X
Bao
Yongzhen
Y
Sun
Jianmin
J
Liu
Jinrong
J
D000368:Aged; D016022:Case-Control Studies; D015352:Dry Eye Syndromes / Q000235:genetics*; D005260:Female; D006801:Humans; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length; D017698:Postmenopause; D011960:Receptors, Estrogen / Q000235:genetics*
D011960:Receptors, Estrogen