title: Cognitive slowing in Parkinson disease is accompanied by hypofunctioning of the striatum.
abstract: OBJECTIVE
  To investigate whether cognitive slowing in Parkinson disease (PD) reflects disruption of the basal ganglia or dysfunction of the frontal lobe by excluding an influence of abnormal brain activity due to motor deficits.
  
  
  METHODS
  We measured neuronal activity during a verbal mental-operation task with H(2)(15)O PET. This task enabled us to evaluate brain activity change associated with an increase in the cognitive speed without an influence on motor deficits.
  
  
  RESULTS
  As the speed of the verbal mental-operation task increased, healthy controls exhibited proportional increase in activities in the anterior striatum and medial premotor cortex, suggesting the involvement of the corticobasal ganglia circuit in normal performance of the task. By contrast, patients with PD lacked an increase in the striatal activity, whereas the medial premotor cortex showed a proportional increase.
  
  
  CONCLUSIONS
  Although the present study chose a liberal threshold and needs subsequent confirmation, the findings suggest that striatal disruption resulting in abnormal processing in the corticobasal ganglia circuit may contribute to cognitive slowing in Parkinson disease, as is the case in motor slowing.
authors: Human Brain Research Center, Kyoto University Graduate School of Medicine, Kyoto, Japan.
authors: N
authors: N
authors: Sawamoto
authors: M
authors: M
authors: Honda
authors: T
authors: T
authors: Hanakawa
authors: T
authors: T
authors: Aso
authors: M
authors: M
authors: Inoue
authors: H
authors: H
authors: Toyoda
authors: K
authors: K
authors: Ishizu
authors: H
authors: H
authors: Fukuyama
authors: H
authors: H
authors: Shibasaki
mesh_terms: D001931:Brain Mapping; D002560:Cerebrovascular Circulation / Q000502:physiology; D003072:Cognition Disorders / Q000000981:diagnostic imaging / Q000209:etiology* / Q000503:physiopathology*; D003342:Corpus Striatum / Q000000981:diagnostic imaging / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009044:Motor Cortex / Q000503:physiopathology; D009434:Neural Pathways / Q000503:physiopathology; D009483:Neuropsychological Tests; D010300:Parkinson Disease / Q000150:complications* / Q000503:physiopathology / Q000523:psychology*; D049268:Positron-Emission Tomography; D011237:Predictive Value of Tests; D011930:Reaction Time / Q000502:physiology; D012016:Reference Values