The absolute stereochemistry and cytotoxicity of the ascidian-derived metabolite, longithorone J.
The absolute stereochemistry of longithorone J (1) from the ascidian Aplidium longithorax has been determined using the advanced Mosher method. Based on biosynthetic reasoning and chiroptical data comparison the absolute stereochemistry for longithorone K (2) was also assigned. Longithorone J was tested for cytotoxicity against the cell lines SHSY5Y, HEK293T and A549. Compound 1 showed minimal cytotoxicity towards the SHSY5Y and HEK293T cell lines.
Davis
Rohan A
RA
Natural Product Discovery, Eskitis Institute, Griffith University, Brisbane, QLD 4111, Australia.
Carroll
Anthony R
AR
Watters
Dianne
D
Quinn
Ronald J
RJ
D000818:Animals; D001952:Bridged-Ring Compounds / Q000737:chemistry* / Q000494:pharmacology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D008958:Models, Molecular; D019906:Nuclear Magnetic Resonance, Biomolecular; D011083:Polycyclic Compounds / Q000737:chemistry* / Q000494:pharmacology; D011809:Quinones; D013237:Stereoisomerism; D014561:Urochordata / Q000737:chemistry*
D001952:Bridged-Ring Compounds; D011083:Polycyclic Compounds; D011809:Quinones; C451180:longithorone A