Physiological role of retinyl palmitate in the skin.
The skin is similar to other organs in how it absorbs, stores, and metabolizes vitamin A. However, because of the anatomical location of skin and the specialized physiological roles it plays, there are ways in which the skin is rather unique. The stratified structure of the epidermis results from the orchestration of retinoid-influenced cellular division and differentiation. Similarly, many of the physiological responses of the skin, such as dermal aging, immune defense, and wound healing, are significantly affected by retinoids. While much is known about the molecular events through which retinoids affect the skin's responses, more remains to be learned. Interest in the effects of retinol, retinyl palmitate, and other retinoids on the skin, fueled in part by the promise of improved dermatologic and cosmetic products, will undoubtedly make the effects of retinoids on skin a subject for continued intense investigation.
Fu
Peter P
PP
National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 72079, USA.
Xia
Qingsu
Q
Boudreau
Mary D
MD
Howard
Paul C
PC
Tolleson
William H
WH
Wamer
Wayne G
WG
D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology / Q000502:physiology*; D004224:Diterpenes; D006801:Humans; D000084562:Retinyl Esters; D012867:Skin / Q000187:drug effects / Q000378:metabolism*; D012879:Skin Physiological Phenomena / Q000187:drug effects*; D014801:Vitamin A / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology / Q000502:physiology
D000975:Antioxidants; D004224:Diterpenes; D000084562:Retinyl Esters; D014801:Vitamin A; C014794:retinol palmitate