Cure of disseminated zygomycosis with cerebral involvement using high dose liposomal amphotericin B and surgery.
We present a case of cerebral zygomycosis that did not respond to standard treatment with amphotericin B or amphotericin B lipid complex. The patient was eventually cured through a combination of surgery and the use of high dose liposomal amphotericin B. Since penetration of the central nervous system by amphotericin B is poor the application of high dose therapy may be useful in cases of cerebral zygomycosis.
Revankar
Sanjay G
SG
Wayne State University, Harper University Hospital, Detroit, Michigan 48201, USA. srevankar@med.wayne.edu
Hasan
M Shahbaz
MS
Smith
James W
JW
D000666:Amphotericin B / Q000008:administration & dosage / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D020314:Central Nervous System Fungal Infections / Q000150:complications / Q000188:drug therapy* / Q000601:surgery*; D003131:Combined Modality Therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D020096:Zygomycosis / Q000150:complications / Q000188:drug therapy* / Q000601:surgery*
D000935:Antifungal Agents; C068538:liposomal amphotericin B; D000666:Amphotericin B