Eurysterols A and B, cytotoxic and antifungal steroidal sulfates from a marine sponge of the genus Euryspongia.
Two new steroidal sulfates, eurysterols A (1) and B (2), were isolated from an undescribed marine sponge of the genus Euryspongia collected in Palau. The structures of the new compounds were assigned by NMR spectroscopic data interpretation. Compounds 1 and 2 showed cytotoxicity against human colon carcinoma (HCT-116) cells with IC50 values of 2.9 and 14.3 microg/mL, respectively, and exhibited antifungal activity against amphotericin B-resistant and wild-type strains of Candida albicans with MIC values, in turn, of 15.6 and 62.5 microg/mL.
Boonlarppradab
Chollaratt
C
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California at San Diego, La Jolla, California 92093-0204, USA. cboonlar@ucsd.edu
Faulkner
D John
DJ
D000666:Amphotericin B / Q000494:pharmacology; D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D004351:Drug Resistance; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008826:Microbial Sensitivity Tests; D019029:Palau; D011161:Porifera; D013261:Sterols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
D000935:Antifungal Agents; D000970:Antineoplastic Agents; D013261:Sterols; C521027:eurysterol A; C521028:eurysterol B; D000666:Amphotericin B