Studies of the action of leucogenenol on the myeloid and lymphoid tissues of the sublethally irradiated mouse.
Studies of the action of leucogenenol on the peripheral leukocytes, the myeloid cells found in bone marrow, and the lymphoid cells found in the spleen of sublethally irradiated mice strongly suggest that leucogenenol stimulates the maturation and/or cellular division of cells of both the myeloid and lymphoid series. Accordingly, as indicated by the increase in the number of peripheral leukocytes, as well as the increase in the number of myeloid and lymphoid cells found in the bone marrow and spleen, mice treated with leucogenenol appear to recover more rapidly than untreated controls.
Rice
F A
FA
Department of Chemistry, The American University, Washington, D. C., USA.
Lepick
J
J
Darden
J H
JH
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects* / Q000502:physiology / Q000528:radiation effects*; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D005260:Female; D007932:Leucogenenol / Q000008:administration & dosage*; D008198:Lymph Nodes / Q000187:drug effects* / Q000502:physiology / Q000528:radiation effects*; D051379:Mice; D022423:Myeloid Cells / Q000187:drug effects* / Q000502:physiology / Q000528:radiation effects*; D011829:Radiation Dosage; D011836:Radiation Tolerance / Q000187:drug effects / Q000502:physiology; D014916:Whole-Body Irradiation
D007932:Leucogenenol