title: Normal cerebrospinal fluid levels of hypocretin-1 (orexin A) in patients with fibromyalgia syndrome.
abstract: BACKGROUND
  The hypothalamic neuropeptide hypocretin (orexin) modulates sleep-wake, feeding and endocrine functions. Cerebrospinal fluid (CSF) hypocretin-1 (Hcrt-1) concentrations are low in patients with narcolepsy-cataplexy, a sleep disorder characterized by hypersomnolence and rapid eye movement (REM) sleep abnormalities.
  
  
  METHODS
  We determined CSF Hcrt-1 concentrations of patients with the fibromyalgia syndrome (FMS), a condition characterized by fatigue, insomnia and in some cases daytime hypersomnolence.
  
  
  RESULTS
  Basal CSF levels of Hcrt-1 in FMS did not differ from those in healthy normal controls.
  
  
  CONCLUSIONS
  These findings suggest that abnormally low Hcrt-1 is not a likely cause of fatigue in FMS.
authors: University of Minnesota, Department of Veterinary and Biomedical Sciences, Rm 295, Animal Science/Veterinary Medicine Building, 1988 Fitch Avenue, St. Paul, MN 55113, USA.
authors: Oludare B
authors: OB
authors: Taiwo
authors: I Jon
authors: IJ
authors: Russell
authors: Emmanuel
authors: E
authors: Mignot
authors: Ling
authors: L
authors: Lin
authors: Joel E
authors: JE
authors: Michalek
authors: Wanda
authors: W
authors: Haynes
authors: Yangming
authors: Y
authors: Xiao
authors: Jamie M
authors: JM
authors: Zeitzer
authors: Alice A
authors: AA
authors: Larson
mesh_terms: D000328:Adult; D000368:Aged; D006970:Disorders of Excessive Somnolence / Q000134:cerebrospinal fluid; D005260:Female; D005356:Fibromyalgia / Q000134:cerebrospinal fluid* / Q000175:diagnosis; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000134:cerebrospinal fluid*; D008297:Male; D008875:Middle Aged; D009479:Neuropeptides / Q000134:cerebrospinal fluid*; D000068797:Orexins; D011863:Radioimmunoassay; D012016:Reference Values; D012895:Sleep, REM / Q000502:physiology; D013223:Statistics as Topic
chemical_list: C000596229:HCRT protein, human; D047908:Intracellular Signaling Peptides and Proteins; D009479:Neuropeptides; D000068797:Orexins