Therapies for bleomycin induced lung fibrosis through regulation of TGF-beta1 induced collagen gene expression.
This review describes normal and abnormal wound healing, the latter characterized by excessive fibrosis and scarring, which for lung can result in morbidity and sometimes mortality. The cells, the extracellular matrix (ECM) proteins, and the growth factors regulating the synthesis, degradation, and deposition of the ECM proteins will be discussed. Therapeutics with particular emphasis given to gene therapies and their effects on specific signaling pathways are described. Bleomycin (BM), a potent antineoplastic antibiotic increases TGF-beta1 transcription, TGF-beta1 gene expression, and TGF-beta protein. Like TGF-beta1, BM acts through the same distal promoter cis-element of the COL1A1 gene causing increased COL1 synthesis and lung fibrosis. Lung fibroblasts exist as subpopulations with one subset predominantly responding to fibrogenic stimuli which could be a specific cell therapeutic target for the onset and development of pulmonary fibrosis.
Cutroneo
Kenneth R
KR
Department of Biochemistry, College of Medicine, 89 Beaumont Avenue, University of Vermont, Burlington, Vermont 05405, USA. kenneth.cutroneo@uvm.edu
White
Sheryl L
SL
Phan
Sem H
SH
Ehrlich
H Paul
HP
D000818:Animals; D000903:Antibiotics, Antineoplastic; D001761:Bleomycin; D003094:Collagen / Q000235:genetics*; D015316:Genetic Therapy / Q000379:methods*; D011658:Pulmonary Fibrosis / Q000139:chemically induced / Q000503:physiopathology / Q000628:therapy*; D053773:Transforming Growth Factor beta1 / Q000235:genetics* / Q000378:metabolism; D014945:Wound Healing / Q000502:physiology
D000903:Antibiotics, Antineoplastic; D053773:Transforming Growth Factor beta1; D001761:Bleomycin; D003094:Collagen