title: C1-esterase inhibitor autoantibodies in a patient with acute tongue swelling.
abstract: Angioedema occurs when there is fluid leakage into the deep dermis of the skin and underlying subcutaneous tissues. Affected individuals usually present with swelling of the face or extremities. Acquired angioedema is an uncommon but potentially life-threatening disease in the older adult population. After the individual is cleared of the initial danger period, a thorough workup for an underlying etiology must be done. We report a 62-year-old male presenting with significant tongue swelling who was diagnosed with acquired angioedema. He had autoantibodies to C1 esterase inhibitor and was subsequently diagnosed with a lymphoma. Angioedema should be recognized by clinicians as a potential presentation of a more ominous malignancy.
authors: David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California, USA. joann@southwestallergy.com
authors: Joann H
authors: JH
authors: Lin
authors: Adrian M
authors: AM
authors: Casillas
authors: Sabah
authors: S
authors: Sattar
mesh_terms: D000208:Acute Disease; D000799:Angioedema / Q000097:blood* / Q000209:etiology; D001323:Autoantibodies / Q000097:blood*; D050718:Complement C1 Inhibitor Protein / Q000276:immunology*; D003937:Diagnosis, Differential; D006801:Humans; D008223:Lymphoma / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D014060:Tongue Diseases / Q000097:blood* / Q000209:etiology
chemical_list: D001323:Autoantibodies; D050718:Complement C1 Inhibitor Protein