Discrimination of Brugada syndrome patients from individuals with the saddle-back type ST-segment elevation using a marker of the standard 12-lead electrocardiography.
BACKGROUND
In the clinical situation, the saddle-back (S-B) type is more frequently detected than the coved type. In the present study, the discrimination of Brugada syndrome from the S-B type individuals using a marker of the standard 12-lead electrocardiography (ECG) was attempted.


RESULTS
The study group consisted of 55 individuals with the S-B type in whom pilsicainide provocation test (PLC test) was carried out. The time from the onset of the QRS wave in lead V(2) (IV (2)) to the peak of the late R-like wave in the QRS wave (PV(2)), and the time from IV(2) to the offset of the QRS wave in lead V(5) (EV(5)) were measured. The coved type was induced by the PLC test in 29 cases (N-C group), but not in the remaining 26 cases (N-N group). The (IV(2) -PV(2)) - (IV(2) - EV(5)) value before the PLS test was greater in the N-C group than in the N-N group. The negative predictive value of ;(IV(2) - PV(2)) - (IV(2) - EV(5)) > or =0' was 76.4% for the prediction of a positive PLC test.


CONCLUSIONS
A ;(IV(2) - PV(2)) - (IV(2) - EV(5)) > or =0' is a useful ECG marker for the discrimination of Brugada syndrome in the S-B type individuals.
Nakazawa
Kiyoshi
K
Division of Cardiology, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan.
Sakurai
Tsuneharu
T
Kishi
Ryoji
R
Takagi
Akihiko
A
Osada
Keizo
K
Ryu
Shonosuke
S
Fujita
Sadanori
S
Matsuda
Hisao
H
Ishikawa
Yukako
Y
Miyake
Fumihiko
F
D000328:Adult; D000368:Aged; D001145:Arrhythmias, Cardiac / Q000175:diagnosis*; D015415:Biomarkers; D053840:Brugada Syndrome / Q000175:diagnosis* / Q000503:physiopathology*; D003937:Diagnosis, Differential; D004562:Electrocardiography / Q000187:drug effects; D005260:Female; D006801:Humans; D008012:Lidocaine / Q000031:analogs & derivatives; D008297:Male; D008875:Middle Aged; D026941:Sodium Channel Blockers
D015415:Biomarkers; D026941:Sodium Channel Blockers; D008012:Lidocaine; C042288:pilsicainide