title: Developing and analyzing idealized models for molecular recognition.
abstract: We study equilibrium aspects of molecular recognition of two biomolecules using idealized model systems and methods from statistical physics. Starting from the basic experimental findings we demonstrate exemplarily how an idealized coarse-grained model for the investigation of molecular recognition of two biomolecules can be developed. In addition we provide details regarding two model systems for the recognition of a flexible and a rigid biomolecule respectively, the latter taking into account conformational changes. We focus particularly on the interplay and influence of the correlations of the residue distributions of the biomolecules on the recognition process.
authors: Fakultät für Physik, Universität Bielefeld, D-33615 Bielefeld, Germany. behringe@Physik.Uni-Bielefeld.DE
authors: Hans
authors: H
authors: Behringer
authors: Thorsten
authors: T
authors: Bogner
authors: Alexey
authors: A
authors: Polotsky
authors: Andreas
authors: A
authors: Degenhard
authors: Friederike
authors: F
authors: Schmid
mesh_terms: D055592:Biophysical Phenomena; D001703:Biophysics; D008954:Models, Biological; D008958:Models, Molecular; D008968:Molecular Conformation; D011485:Protein Binding; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism; D013329:Structure-Activity Relationship; D049490:Systems Biology / Q000379:methods
chemical_list: D011506:Proteins