title: Occult donor malignancy in pancreas transplantation.
abstract: Tumor of the pancreas allograft is extremely rare. We report a case of an occult donor malignant undifferentiated tumor arising in a pancreas allograft. A 42-year-old female with Type 1 diabetes received a macroscopically normal pancreas allograft. The donor was a 22-year-old male who died of spontaneous intracerebral hemorrhage. She underwent transplant pancreatectomy, the histology of the pancreas allograft demonstrated a tumor measuring 5 mm in diameter, and a diagnosis of malignant undifferentiated tumor was made. In a different transplant center, the recipient of the left kidney transplant from the same donor had a nephrectomy, and the recipient of the liver transplant died of metastatic disease. Microscopic examination of the liver and kidney allografts subsequently revealed histological features identical to the pancreas tumor. Tumor transmission in transplantation may occur from an organ that contains metastatic cells or, less commonly, from the transmission of an unrecognized or occult primary tumor. A report from the United Network for Organs Sharing transplant data 1997-2002 is illustrated and discussed. This case illustrates the difficulties associated with identifying donors with occult primary tumor or metastases.
authors: Department of Nephrology, Royal Liverpool University Hospital, Liverpool, England. chriswong@doctors.org.uk
authors: Christopher
authors: C
authors: Wong
authors: Phoebe
authors: P
authors: Hold
authors: Mobin
authors: M
authors: Mohteshamzadeh
authors: Raman
authors: R
authors: Dhanda
authors: Robert
authors: R
authors: Sells
mesh_terms: D000328:Adult; D003922:Diabetes Mellitus, Type 1 / Q000601:surgery*; D005134:Eye Neoplasms / Q000209:etiology*; D005260:Female; D006801:Humans; D009369:Neoplasms / Q000453:epidemiology; D016035:Pancreas Transplantation / Q000009:adverse effects* / Q000473:pathology; D011183:Postoperative Complications / Q000453:epidemiology / Q000473:pathology; D012189:Retrospective Studies; D014019:Tissue Donors; D014184:Transplantation, Homologous