Phosphotyrosine/phosphoserine binary switches: a new paradigm for the regulation of PI3K signalling and growth factor pleiotropy?
Cytokines and growth factors exert multiple biological activities through their ability to engage and activate specific receptors displayed on the surface of cells. How these receptors are able to differentially (and sometimes independently) regulate cell survival, proliferation, differentiation and activation to control quite specific and distinct cellular outcomes is unclear. Similarly, how a single growth factor or cytokine receptor can specify alternate cellular responses and control very different cellular fates is also not known. We present a new mechanism by which cytokines and growth factors are able to control these pleiotropic responses.
Guthridge
M A
MA
Cytokine Receptor Laboratory, Department of Human Immunology, Hanson Institute, Institute of Medical and Veterinary Science, Frome Rd, Adelaide, SA, Australia. mark.guthridge@imvs.sa.gov.au
Lopez
A F
AF
D000818:Animals; D016207:Cytokines / Q000502:physiology; D006133:Growth Substances / Q000502:physiology*; D006706:Homeostasis; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000502:physiology; D008954:Models, Biological; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism*; D010768:Phosphoserine / Q000378:metabolism*; D019000:Phosphotyrosine / Q000378:metabolism*; D016187:Receptors, Granulocyte-Macrophage Colony-Stimulating Factor / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D018909:src Homology Domains
D016207:Cytokines; D006133:Growth Substances; D036341:Intercellular Signaling Peptides and Proteins; D016187:Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; D010768:Phosphoserine; D019000:Phosphotyrosine; D019869:Phosphatidylinositol 3-Kinases