Assessment and prevention of head motion during imaging of patients with attention deficit hyperactivity disorder.
The present study serves to detail the specific procedures for a mock scanner protocol, report on its use in the context of a multi-site study, and make suggestions for improving such protocols based on data acquired during study scanning. Specifically, a mock scanner compliance training protocol was used in a functional imaging study with a group of adolescents and adults with Attention Deficit Hyperactivity Disorder (ADHD) and a matched sample of healthy children and adults. Head motion was measured during mock and actual scanning. Participants across groups exhibited excess motion (>2 mm) on 43% of runs during the mock scanner. During actual scanning, excessive motion was limited to 10% of runs. There was a clear task-correlated head motion during a go/no-go task that occurred even after the compliance training: participants had a tendency to respond with increased head motion immediately after committing an error. This study illustrates the need to (1) report data attrition due to head motion, (2) assess task-related motion, and (3) consider mock scanner training in functional imaging protocols.
Epstein
Jeffery N
JN
Department of Pediatrics, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, ML 10006, Cincinnati, OH 45229, USA. jeff.epstein@cchmc.org
Casey
B J
BJ
Tonev
Simon T
ST
Davidson
Matthew
M
Reiss
Allan L
AL
Garrett
Amy
A
Hinshaw
Stephen P
SP
Greenhill
Laurence L
LL
Vitolo
Alan
A
Kotler
Lisa A
LA
Jarrett
Matthew A
MA
Spicer
Julie
J
D000328:Adult; D001289:Attention Deficit Disorder with Hyperactivity / Q000175:diagnosis*; D002648:Child; D005260:Female; D006257:Head / Q000502:physiology*; D006801:Humans; D007103:Immobilization / Q000379:methods*; D008279:Magnetic Resonance Imaging; D008297:Male; D008954:Models, Biological; D009068:Movement / Q000502:physiology*; D010287:Parent-Child Relations