Antioxidant xanthones from Cratoxylum cochinchinense.
A new xanthone named cratoxylumxanthone A (1), together with five known compounds: dulcisxanthone B (2), alpha-mangostin (3), beta-mangostin (4), 2-geranyl-1,3,7-trihydroxy-4-(3-methylbut-2-enyl)xanthone (5) and tectochrystin (6), was isolated from Cratoxylum cochinchinense stems. The structure of new compound was characterized by 1D and 2D NMR techniques. The isolated compounds showed free radical scavenging against DPPH and lipid peroxidation inhibition.
Phuwapraisirisan
Preecha
P
Natural Product Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand. preecha.p@chula.ac.th
Udomchotphruet
Sutee
S
Surapinit
Serm
S
Tip-Pyang
Santi
S
D000818:Animals; D000975:Antioxidants / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000378:metabolism; D028084:Clusiaceae / Q000737:chemistry*; D016166:Free Radical Scavengers / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006834:Hydrazines / Q000378:metabolism; D008054:Lipid Peroxides / Q000378:metabolism; D019906:Nuclear Magnetic Resonance, Biomolecular; D010851:Picrates; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018547:Plant Stems / Q000737:chemistry; D051381:Rats; D021241:Spectrometry, Mass, Electrospray Ionization; D013056:Spectrophotometry, Ultraviolet; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D044004:Xanthones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*
D000975:Antioxidants; D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D006834:Hydrazines; D008054:Lipid Peroxides; D010851:Picrates; D010936:Plant Extracts; D017392:Thiobarbituric Acid Reactive Substances; D044004:Xanthones; C004931:1,1-diphenyl-2-picrylhydrazyl