title: Cardiac GPCRs: GPCR signaling in healthy and failing hearts.
abstract: G protein-coupled receptors (GPCRs) are widely implicated in human heart disease, making them an important target for cardiac drug therapy. The most commonly studied and clinically targeted cardiac GPCRs include the adrenergic, angiotensin, endothelin, and adenosine receptors. Treatment options focusing on the complex and integrated signaling pathways of these GPCRs are critical for the understanding and amelioration of heart disease. The focus of this review is to highlight the most commonly studied and clinically targeted cardiac GPCRs, placing emphasis on their common signaling components implicated in cardiac disease.
authors: Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
authors: Natasha C
authors: NC
authors: Salazar
authors: Juhsien
authors: J
authors: Chen
authors: Howard A
authors: HA
authors: Rockman
mesh_terms: D000818:Animals; D006331:Heart Diseases / Q000378:metabolism*; D006801:Humans; D051379:Mice; D009206:Myocardium / Q000378:metabolism*; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D043562:Receptors, G-Protein-Coupled; D019869:Phosphatidylinositol 3-Kinases