In vivo antitussive potentiality of Lagerstroemia parviflora flower extract using a cough model induced by sulfur dioxide in mice.
The methanol extract of the flowers of Lagerstroemia parviflora Roxb (Family: Lythraceae) was investigated for its effect on a cough model induced by sulphur dioxide gas in mice. It exhibited significant antitussive activity when compared with the control in a dose-dependent manner. The extract (100, 200, 300 mg kg(-1)) showed maximum inhibition of cough reflex at 90 min after drug administration and the antitussive activity was comparable to that of codeine phosphate, a standard antitussive agent.
Mazumder
Avijit
A
Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra, Ranchi 835 215, India. avijitmazum@yahoo.com
Bhattacharya
S
S
Mazumder
Rupa
R
D000465:Algorithms; D000818:Animals; D000996:Antitussive Agents / Q000494:pharmacology*; D003371:Cough / Q000139:chemically induced* / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D035264:Flowers / Q000737:chemistry; D031563:Lagerstroemia / Q000737:chemistry*; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology; D013458:Sulfur Dioxide
D000996:Antitussive Agents; D010936:Plant Extracts; D013458:Sulfur Dioxide