The chemical and biochemical properties of methylphosphotriester DNA and RNA in comparison with their corresponding methylphosphonates. A dynamic model description.
Methylphosphotriester DNA and RNA are of great interest to investigate their hybridization affinity with natural DNA and RNA with respect to their physical and biological properties. The results are compared with related modified oligonucleotides. Specific attention will be given to the development of recent antiretroviral nucleosides focused on their molecular conformation and the mechanistic aspects based on the physical properties of phosphorus in a trigonal bipyramidal configuration corresponding with in vitro and in vivo kinetics.
Buck
Henk M
HM
Kasteel Twikkelerf 94, Tilburg, 5037 TW, The Netherlands. theavandervelden@yahoo.com
D004247:DNA / Q000737:chemistry*; D004261:DNA Replication; D008956:Models, Chemical; D009943:Organophosphorus Compounds / Q000737:chemistry*; D012313:RNA / Q000737:chemistry*
D009943:Organophosphorus Compounds; D012313:RNA; D004247:DNA