title: Antibodies against botulinum neurotoxin type A as a cause of treatment failure after the first detrusor injection.
abstract: Botulinum neurotoxins are increasingly used in treatment for hyperactive detrusor and sphincter function. Although reported results are promising, conditions in some patients are refractory. We report what we believe to be the first urologic case of therapy failure possibly induced by botulinum toxin antibodies after just one injection and discuss treatment alternatives based on experience in other fields.
authors: Department of Urology, St. Hedwig Hospital, Charité Medical School, Humboldt University, Berlin, Germany. hschultebaukloh@hotmail.com
authors: Heinrich
authors: H
authors: Schulte-Baukloh
authors: Hans
authors: H
authors: Bigalke
authors: Gert
authors: G
authors: Heine
authors: Daniela
authors: D
authors: Pape
authors: Burkard
authors: B
authors: Stuerzebecher
authors: Kurt
authors: K
authors: Miller
authors: Helmut H
authors: HH
authors: Knispel
mesh_terms: D000283:Administration, Intravesical; D000368:Aged; D000906:Antibodies / Q000032:analysis; D019274:Botulinum Toxins, Type A / Q000008:administration & dosage / Q000276:immunology*; D006801:Humans; D008297:Male; D009465:Neuromuscular Agents / Q000008:administration & dosage / Q000276:immunology*; D009498:Neurotoxins / Q000008:administration & dosage / Q000276:immunology*; D017211:Treatment Failure; D014555:Urination Disorders / Q000188:drug therapy* / Q000503:physiopathology; D014563:Urodynamics
chemical_list: D000906:Antibodies; D009465:Neuromuscular Agents; D009498:Neurotoxins; D019274:Botulinum Toxins, Type A