Serum elastase and antithrombin-3 levels after umbilical cord blood transplantation or bone marrow transplantation.
The severity of graft-versus-host disease (GVHD) was compared after cord blood transplantation (CBT) and bone marrow transplantation (BMT). The severity of GVHD was also analyzed in relation to serum elastase and antithrombin-3 (AT-3) levels. There was no significant difference in the average grade of acute GVHD between 49 BMT patients and 20 CBT patients (chi2-test). However, there was a lower incidence of patients without acute GVHD (grade 0) or patients with severe acute GVHD (grade 3 or 4) in CBT compared with BMT group. Linear regression analysis found no significant correlation between the serum elastase level and the grade of acute GVHD, between the serum AT-3 level and the grade of acute GVHD, or between the serum levels of elastase and AT-3 before conditioning and after engraftment. The AT-3 level after engraftment was significantly higher in the CBT group than in the BMT group and it did not fail along with the elevation of elastase in the CBT group (p < 0.01 by the Mann-Whitney U-test vs. the BMT group). In conclusion, the lower risk of severe acute GVHD in the CBT group may have been related to the smaller decrease of AT-3 after transplantation.
Toda
Akinari
A
Division of Hematology, Department of Internal Medicine, Hyogo College of Medicine, Hyogo, Japan.
Takatsuka
Hiroyuki
H
Nakajima
Toshiyuki
T
Nomura
Kaori
K
Wakae
Takeshi
T
Itoi
Hisayuki
H
Okada
Masaya
M
Misawa
Mahito
M
Hara
Hiroshi
H
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000990:Antithrombin III / Q000032:analysis*; D015415:Biomarkers; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D016009:Chi-Square Distribution; D036101:Cord Blood Stem Cell Transplantation / Q000009:adverse effects*; D005260:Female; D006086:Graft vs Host Disease / Q000097:blood / Q000209:etiology*; D006402:Hematologic Diseases / Q000097:blood / Q000601:surgery; D019337:Hematologic Neoplasms / Q000097:blood / Q000601:surgery; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D010196:Pancreatic Elastase / Q000097:blood*; D011237:Predictive Value of Tests; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric; D014184:Transplantation, Homologous / Q000009:adverse effects*
D015415:Biomarkers; D000990:Antithrombin III; D010196:Pancreatic Elastase