[Outpatient clinic facilities for clinical-laboratory diagnosis of hepatic fibrosis].
OBJECTIVE
To compare fibrosis stages estimated by histological data obtained at biopsy of hepatic tissue with fibrosis index (FI) calculated with the dominant calculation scale (DCS); to define diagnostic thresholds, sensitivity and specificity of FI estimation.


METHODS
The trial included 75 chronic hepatitis (CH) patients (54 males and 21 females, mean age 37.4 +/- 9.5 years) with different activity of the disease and at different stages of CH: 51 (68%) with virus hepatitis C (VHC), 8 (10.7%) with virus hepatitis B (VHB), 11 (14.7%) with alcoholic hepatitis and 5 (6.7%) with non-alcohol steatohepatitis (NASH). Puncture hepatic biopsy specimens were obtained from all the examinees. Fibrosis stages were determined by METAVIR. FI by DCS was calculated by the score sum of prothrombin index, platelet count, ALT/AST.


RESULTS
By METAVIR, F0 corresponded to FI 1.84 +/- 0.79, F4 (cirrhosis)--to 7.14 +/- 0.64; by ISHAK, F0 corresponded to FI 1.89 +/- 0.35, F6 (cirrhosis)--to 7.33 +/- 0.33. Sensitivity and specificity of FI estimation by DCS depending on fibrosis stage for METAVIR was 88% and 88%, for ISHAK--88% and 82.7%, respectively. In interferon therapy FI elevates due to iatrogenic thrombocytopenia.
Minushkin
O N
ON
Leont'ev
S I
SI
Maslovskiĭ
L V
LV
Zverkov
I V
IV
D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D000553:Ambulatory Care / Q000379:methods*; D000554:Ambulatory Care Facilities; D001219:Aspartate Aminotransferases / Q000097:blood; D001706:Biopsy; D019411:Clinical Laboratory Techniques; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood / Q000175:diagnosis*; D008297:Male; D010976:Platelet Count; D011516:Prothrombin / Q000378:metabolism; D012720:Severity of Illness Index
D011516:Prothrombin; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase