title: Hepaticojejunostomy--analysis of risk factors for postoperative bile leaks and surgical complications.
abstract: Anastomoses between the jejunum and the bile duct are an important component of many surgical procedures; however, risk factors for clinically relevant bile leaks have not yet been adequately defined. The objective of this study was to describe the incidence of bile leaks after hepaticojejunostomy and to define predictive factors associated with this risk and with surgical morbidity. Between October 2001 and April 2004, hepaticojejunostomies were performed in 519 patients in a standardized way. Patient- and treatment-related data were documented prospectively. A bile leak was defined as bilirubin concentration in the drains exceeding serum bilirubin with a consecutive change of clinical management or occurrence of a bilioma necessitating drainage. Surgical morbidity occurred in 15% of patients, the incidence of a bile leak was 5.6%. Multivariate analysis confirmed preoperative radiochemotherapy, preoperative low cholinesterase levels, biliary complications after liver transplantation necessitating a hepaticojejunostomy, and simultaneous liver resection as risk factors for bile leakages, whereas biliary complications after liver transplantation necessitating hepaticojejunostomy, simultaneous liver resection, and diabetes mellitus were significantly associated with postoperative surgical morbidity. Our results demonstrate that hepaticojejunostomy is a safe procedure if performed in a standardized fashion. The above found factors may help to better predict the risk for complications after hepaticojejunostomy.
authors: Department of Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany.
authors: Dalibor
authors: D
authors: Antolovic
authors: Moritz
authors: M
authors: Koch
authors: Luis
authors: L
authors: Galindo
authors: Sandra
authors: S
authors: Wolff
authors: Emira
authors: E
authors: Music
authors: Peter
authors: P
authors: Kienle
authors: Peter
authors: P
authors: Schemmer
authors: Helmut
authors: H
authors: Friess
authors: Jan
authors: J
authors: Schmidt
authors: Markus W
authors: MW
authors: Büchler
authors: Jürgen
authors: J
authors: Weitz
mesh_terms: D000368:Aged; D000714:Anastomosis, Surgical / Q000009:adverse effects*; D001646:Bile; D001663:Bilirubin / Q000032:analysis / Q000097:blood; D017024:Chemotherapy, Adjuvant; D002802:Cholinesterases / Q000032:analysis; D048909:Diabetes Complications; D004322:Drainage; D005260:Female; D005544:Forecasting; D006498:Hepatectomy / Q000009:adverse effects; D006500:Hepatic Duct, Common / Q000601:surgery*; D006801:Humans; D007583:Jejunum / Q000601:surgery*; D016031:Liver Transplantation / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D011446:Prospective Studies; D018714:Radiotherapy, Adjuvant; D012307:Risk Factors; D012449:Safety; D016896:Treatment Outcome
chemical_list: D002802:Cholinesterases; D001663:Bilirubin