title: [Alternative development of early embryogenesis: sex determination].
abstract: Sex determination is a complex regulatory process of early embryogenesis. Embryo must make a developmental decision to develop as a male or female during gonadogenesis. This paper reviews genetic systems of sex determination, gonadogenesis, key genes involved in sex determination of vertebrates. Molecular evolution processes of sex chromosomes and sex determination provide a clue to tendency of sex-determining genes to appear on heterotypic sex chromosome.
authors: Department of Genetics and Center for Developmental Biology, College of Life Sciences, Wuhan University, Wuhan, China. hhcheng@whu.edu.cn
authors: Han-Hua
authors: HH
authors: Cheng
authors: Rong-Jia
authors: RJ
authors: Zhou
mesh_terms: D000818:Animals; D047108:Embryonic Development / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008957:Models, Genetic; D012730:Sex Chromosomes / Q000235:genetics; D019849:Sex Determination Processes