title: Surgical closure of atrial septal defect in patients older than 30 years: risk factors for late death from arrhythmia or heart failure.
abstract: BACKGROUND
  Little is known about prognostic markers for late cardiac-related death after surgical atrial septal defect (ASD) closure in adults.
  
  
  METHODS
  Long-term follow-up data of 281 patients who underwent surgical secundum ASD closure when they were older than 30 years, were retrospectively examined.
  
  
  RESULTS
  Mean age at surgery was 43.8 +/- 10.0 years (30 to 76 years). There were 2 early deaths. Mean follow-up was 14.1 +/- 8.4 years (0.4 to 28.9 years). Death from arrhythmia or heart failure occurred in 9 patients (3.6 %) at a mean time of 8.5 +/- 6.6 years after the operation. Patients > 43 years exhibited significantly higher pulmonary artery pressures. Preoperative systolic pulmonary artery pressure > 36 mmHg, and mean pulmonary artery pressure > 21 mmHg were predictive of late death from arrhythmia or heart failure. However, age at operation was not.
  
  
  CONCLUSIONS
  Older age at the time of ASD closure is not a risk factor for late death from arrhythmia or heart failure in adults. However, older patients presented more often with pulmonary hypertension. Since elevated pulmonary artery pressure is predictive of late death from arrhythmia or heart failure, timely ASD closure is warranted.
authors: Clinic for Cardiovascular Surgery, German Heart Center Munich at the Technical University, Munich, Germany. hoerer@dhm.mhn.de
authors: J
authors: J
authors: Hörer
authors: S
authors: S
authors: Müller
authors: C
authors: C
authors: Schreiber
authors: M
authors: M
authors: Kostolny
authors: J
authors: J
authors: Cleuziou
authors: Z
authors: Z
authors: Prodan
authors: K
authors: K
authors: Holper
authors: R
authors: R
authors: Lange
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D001145:Arrhythmias, Cardiac / Q000209:etiology / Q000401:mortality* / Q000503:physiopathology; D006348:Cardiac Surgical Procedures; D002315:Cardiopulmonary Bypass; D005260:Female; D006333:Heart Failure / Q000209:etiology / Q000401:mortality* / Q000503:physiopathology; D006344:Heart Septal Defects, Atrial / Q000503:physiopathology / Q000601:surgery*; D017052:Hospital Mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000209:etiology / Q000401:mortality / Q000503:physiopathology; D011237:Predictive Value of Tests; D011669:Pulmonary Wedge Pressure; D012189:Retrospective Studies; D012307:Risk Factors; D016019:Survival Analysis; D013997:Time Factors; D016896:Treatment Outcome