Chemoselective derivatization of a bionanoparticle by click reaction and ATRP reaction.
Horse spleen apoferritin, the hollow protein shell derived from ferritin, a special biological nanoparticle, can be chemoselectively modified at the lysine residues, which affords a robust scaffold for further chemical reactions including Cu(i)-catalyzed azide-alkyne cycloaddition reaction and atom transfer radical polymerization reaction.
Zeng
Qingbing
Q
Department of Chemistry and Biochemistry and Nanocenter, University of South Carolina, Columbia, SC 29208, USA.
Li
Tao
T
Cash
Brandon
B
Li
Siqi
S
Xie
Fang
F
Wang
Qian
Q
D000107:Acetylation; D000818:Animals; D001052:Apoferritins / Q000737:chemistry*; D020650:Combinatorial Chemistry Techniques; D003300:Copper / Q000737:chemistry*; D006736:Horses; D008239:Lysine / Q000737:chemistry; D053758:Nanoparticles / Q000737:chemistry*
D003300:Copper; D001052:Apoferritins; D008239:Lysine