title: Russell body gastritis: expanding the spectrum of Helicobacter pylori - related diseases?
abstract: We report a new case of Helicobacter pylori gastritis showing plasma cell infiltrates with extensive formation of Russell bodies (Mott cells) within the lamina propria of the antral mucosa. The patient was a 60-year-old woman with a history of epigastric pain. Endoscopy revealed non-specific congestion of the mucosa. Microscopically, the intracytoplasmic inclusions were homogeneous, mainly round to oval, and pushed the nucleus toward the periphery. They were intensely PAS-positive and reacted to antibodies against polytypic light chains, CD79a, and anti-plasma cell antibody. Because of the accumulation of intracytoplasmic inclusions, Russell body gastritis is a potential source of diagnostic difficulties in endoscopic biopsy specimens that can be confused with immunocytic neoplasms, such as lymphoplasmacytic lymphoma or plasmocytoma, or signet-ring cell carcinoma. In the light of similar cases published previously, it seems as if the association between Russell body gastritis and Helicobacter pylori infection is not merely coincidental.
authors: Department of Pathology, General Hospital S. Maria della Misericordia, Udine, Italy.
authors: Stefano
authors: S
authors: Pizzolitto
authors: Debora
authors: D
authors: Camilot
authors: Giovanna
authors: G
authors: DeMaglio
authors: Giovanni
authors: G
authors: Falconieri
mesh_terms: D051925:CD79 Antigens / Q000032:analysis; D005260:Female; D005753:Gastric Mucosa / Q000276:immunology / Q000473:pathology / Q000821:virology; D005756:Gastritis / Q000276:immunology / Q000473:pathology / Q000821:virology*; D016481:Helicobacter Infections / Q000150:complications* / Q000276:immunology / Q000473:pathology / Q000821:virology; D016480:Helicobacter pylori / Q000302:isolation & purification*; D006801:Humans; D007145:Immunoglobulin kappa-Chains / Q000032:analysis; D007146:Immunoglobulin lambda-Chains / Q000032:analysis; D007181:Inclusion Bodies, Viral / Q000473:pathology; D008875:Middle Aged; D010503:Periodic Acid-Schiff Reaction; D010950:Plasma Cells / Q000276:immunology / Q000473:pathology / Q000821:virology*; D011706:Pyloric Antrum / Q000276:immunology / Q000473:pathology / Q000821:virology*
chemical_list: D051925:CD79 Antigens; C497881:CD79A protein, human; D007145:Immunoglobulin kappa-Chains; D007146:Immunoglobulin lambda-Chains