title: Quality of life in dementia: care recipient and caregiver perceptions of quality of life in dementia: the LASER-AD study.
abstract: BACKGROUND
  Quality of Life (QoL) is a key outcome in dementia.
  
  
  OBJECTIVE
  To compare care recipients' (CR) and caregivers' (CG) views on CRs' QoL and identify determinants.
  
  
  METHODS
  CRs and CGs completed the Quality of Life - Alzheimer's Disease (QOL-AD) scale.
  
  
  RESULTS
  One hundred and ninety-one CR/CG dyads were interviewed. There were differences between determinants of the CRs and CGs views about QoL. Family-CGs rated CRs' QoL higher when CRs had fewer depressive symptoms, less irritability, less apathy, less daily living impairment and lived at home. Fewer depressive symptoms, living at home and taking acetylcholinesterase-inhibitors (AChEI) predicted higher CR rated QoL.
  
  
  CONCLUSIONS
  Proxy ratings in dementia do not replicate CRs' views of QoL. This is the first study to employ a validated QoL measure for people with dementia taking AChEIs. Randomised controlled trials are needed before drawing conclusions about their effect on QoL. Interpretation of correlations between QoL and symptoms should be cautious as QoL is designed to reflect the impact of psychological and physical symptoms.
authors: University College London, London, UK. j.hoe@ucl.ac.uk
authors: Juanita
authors: J
authors: Hoe
authors: Cornelius
authors: C
authors: Katona
authors: Martin
authors: M
authors: Orrell
authors: Gill
authors: G
authors: Livingston
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000523:psychology*; D017028:Caregivers / Q000523:psychology*; D002800:Cholinesterase Inhibitors / Q000627:therapeutic use; D003704:Dementia / Q000523:psychology*; D004185:Disability Evaluation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D011788:Quality of Life / Q000523:psychology*; D012044:Regression Analysis
chemical_list: D002800:Cholinesterase Inhibitors