title: Molecular characterization of a ring chromosome 15 in a fetus with intra uterine growth retardation and diaphragmatic hernia.
abstract: OBJECTIVE
  To improve the phenotype-genotype correlation in terminal 15q deletions and ring chromosome 15 syndrome.
  
  
  METHODS
  Echographic examination of fetus. R-banded chromosome and FISH analysis on cultured amniocytes. Microsatellite analysis to determine parental origin of the ring chromosome 15. Fetal autopsy.
  
  
  RESULTS
  We report a new case of prenatal diagnosis of congenital diaphragmatic hernia and intrauterine growth retardation in a fetus with ring chromosome 15 involving 15q26.1-qter deletion.
  
  
  CONCLUSIONS
  This case support the evidence that the region 15q26.3 is implicated in intrauterine growth retardation and suggests that the 15q critical region implicated in congenital diaphragmatic hernia is localized in 15q26.1-q26.2.
authors: Cytogenetics and Reproductive Biology Department, Farhat Hached University Teaching Hospital, Sousse, Tunisia. hatem.elghezal@rns.tn
authors: Elghezal
authors: E
authors: Hatem
authors: Ben Rekaya
authors: BR
authors: Meriam
authors: Denguezli
authors: D
authors: Walid
authors: Moussa
authors: M
authors: Adenen
authors: Gribaa
authors: G
authors: Moez
authors: Saad
authors: S
authors: Ali
mesh_terms: D000015:Abnormalities, Multiple / Q000175:diagnosis / Q000196:embryology / Q000235:genetics; D000025:Abortion, Eugenic; D000328:Adult; D002884:Chromosomes, Human, Pair 15; D003937:Diagnosis, Differential; D005260:Female; D005317:Fetal Growth Retardation / Q000175:diagnosis* / Q000235:genetics; D006548:Hernia, Diaphragmatic / Q000150:complications / Q000175:diagnosis* / Q000196:embryology / Q000235:genetics; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D011247:Pregnancy; D011296:Prenatal Diagnosis; D012303:Ring Chromosomes