Bromoalterochromides A and A', unprecedented chromopeptides from a marine Pseudoalteromonas maricaloris strain KMM 636T.
The marine strain Pseudoalteromonas maricaloris KMM 636T was found to produce an inseparable mixture of two brominated yellow main pigments, bromoalterochromide A and A', in a ratio of 3: 1. Both pigments are Thr-Val-Asn-Asn-X pentapeptide lactones, where the amino group of Thr is acylated with 9-(3-bromo-4-hydroxyphenyl)-nona-2,4,6,8-tetraenoic acid, and X is aIle and Leu, respectively. They possess cytotoxic effects on developing eggs of the sea urchin Strongylocentrotus intermedius, but no antibiotic activity.
Speitling
Michael
M
Department of Organic and Biomolecular Chemistry, University of Gottingen, Tammannstrasse 2, D-37077 Gottingen, Germany.
Smetanina
Olga F
OF
Kuznetsova
Tatyana A
TA
Laatsch
Hartmut
H
D000818:Animals; D001419:Bacteria / Q000187:drug effects; D001966:Bromine / Q000032:analysis*; D047630:Depsipeptides / Q000096:biosynthesis / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D010063:Ovum / Q000187:drug effects; D010860:Pigments, Biological / Q000096:biosynthesis / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D031161:Pseudoalteromonas / Q000737:chemistry*; D047269:Strongylocentrotus / Q000187:drug effects
D047630:Depsipeptides; D010860:Pigments, Biological; C518891:bromoalterochromide A; C518892:bromoalterochromide A'; D001966:Bromine