Hyperpolarization-activated cyclic nucleotide-gated channel gene: the most possible therapeutic applications in the field of cardiac biological pacemakers.
The implantation of electronic devices has become the preferred treatment for symptomatic bradyarrhythmias. However, there are many shortcomings in electronic pacemakers. More recently, the data has suggested that application of hyperpolarization-activated cyclic nucleotide-gated (HCN) channel gene may hold great promise in development of biological pacemaker. The evidence for the hypotheses included that: (1) The expression of four HCN genes varies somewhat among cardiac tissue. And also, the main difference between pacemaker cells and common cardiomyocytes depends upon which HCN genes are fully expressed; (2) the animals lacking HCN channels show a pronounced cardiac phenotype, which is due to dysfunction of the sinus node; (3) it is suggested that primary defects in HCN channels might underlie certain cardiac arrhythmias in several families with hereditary sinus node dysfunction; (4) recently, several studies demonstrated that overexpression of HCN gene in myocytes via gene delivery or implantation of stem cells with overexpression of I(f) successfully induced automaticity of a biological pacemaker in arrhythmic animal models.
Zhou
Ya-Feng
YF
Department of Cardiology, The First Affiliated Hospital of Soochow University, Suzhou City, Jiangsu Province 215006, PR China.
Yang
Xiang-Jun
XJ
Li
Hong-Xia
HX
D000818:Animals; D001683:Biological Clocks; D054815:Cyclic Nucleotide-Gated Cation Channels; D018014:Gene Transfer Techniques; D064428:Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; D007473:Ion Channels / Q000235:genetics / Q000502:physiology; D051379:Mice; D018345:Mice, Knockout; D008954:Models, Biological; D009154:Mutation; D009206:Myocardium / Q000378:metabolism; D032383:Myocytes, Cardiac / Q000378:metabolism; D010641:Phenotype; D020033:Protein Isoforms; D013234:Stem Cells / Q000166:cytology
D054815:Cyclic Nucleotide-Gated Cation Channels; D064428:Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; D007473:Ion Channels; D020033:Protein Isoforms