title: Covalent bonding of vancomycin to Ti6Al4V alloy pins provides long-term inhibition of Staphylococcus aureus colonization.
abstract: Self-protecting Ti6Al4V alloy pins were prepared by covalent bonding of bis(ethylene glycol) linkers, then vancomycin to the oxidized, aminopropylated Ti6Al4V alloy surface. Fluorescence modification-enabled estimation of yields of free amines on the metallic surface monolayer at each reaction step. The vancomycin-protected Ti6Al4V pins were not colonized by Staphylococcus aureus, even after 44days storage in physiological buffer. These results provide a basis for testing self-protection against S. aureus colonization in animal models.
authors: Department of Biochemistry & Molecular Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.
authors: Om P
authors: OP
authors: Edupuganti
authors: Valentin
authors: V
authors: Antoci
authors: Samuel B
authors: SB
authors: King
authors: Binoy
authors: B
authors: Jose
authors: Christopher S
authors: CS
authors: Adams
authors: Javad
authors: J
authors: Parvizi
authors: Irving M
authors: IM
authors: Shapiro
authors: Allen R
authors: AR
authors: Zeiger
authors: Noreen J
authors: NJ
authors: Hickok
authors: Eric
authors: E
authors: Wickstrom
mesh_terms: D000497:Alloys; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000254:growth & development; D013995:Time; D014025:Titanium / Q000737:chemistry*; D014640:Vancomycin / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000497:Alloys; C031462:titanium alloy (TiAl6V4); D014640:Vancomycin; D014025:Titanium