title: Flavonoids and laryngeal cancer risk in Italy.
abstract: BACKGROUND
  Flavonoids may play an important role in explaining the protective effect of vegetables and fruit against cancer.
  
  
  METHODS
  To investigate the relation between flavonoids and laryngeal cancer risk, we have applied data on the composition of foods and beverages in terms of six principal classes of flavonoids to a case-control study of laryngeal cancer conducted from 1992 to 2000 in Italy. Cases were 460 subjects with incident, histologically confirmed laryngeal cancer; controls were 1088 patients admitted for acute, non-neoplastic diseases. Odds ratios (OR) were estimated through multiple logistic regression models, including terms for sociodemographic and lifestyle factors, tobacco smoking, alcohol consumption and energy intake.
  
  
  RESULTS
  Significant inverse relations were found for the highest versus the lowest quintile of intake for flavan-3-ols (OR = 0.64), flavanones (OR = 0.60), flavonols (OR = 0.32) and total flavonoids (OR = 0.60), although the overall trends in risk were significant only for flavanones and flavonols. No consistent associations were observed for isoflavones, anthocyanidins and flavones. The estimates did not differ substantially across strata of alcohol drinking, tobacco smoking, body mass index and education, and tended to persist even after controlling for vegetable and fruit intake.
  
  
  CONCLUSIONS
  This study provides support for a beneficial effect of selected flavonoids on laryngeal cancer risk.
authors: Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.
authors: W
authors: W
authors: Garavello
authors: M
authors: M
authors: Rossi
authors: J K
authors: JK
authors: McLaughlin
authors: C
authors: C
authors: Bosetti
authors: E
authors: E
authors: Negri
authors: P
authors: P
authors: Lagiou
authors: R
authors: R
authors: Talamini
authors: S
authors: S
authors: Franceschi
authors: M
authors: M
authors: Parpinel
authors: L
authors: L
authors: Dal Maso
authors: C
authors: C
authors: La Vecchia
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D004032:Diet; D005419:Flavonoids / Q000633:toxicity*; D006801:Humans; D007558:Italy / Q000453:epidemiology; D007822:Laryngeal Neoplasms / Q000453:epidemiology*; D008875:Middle Aged; D012307:Risk Factors; D012907:Smoking / Q000453:epidemiology; D011795:Surveys and Questionnaires
chemical_list: D005419:Flavonoids