Anti-hypertensive effects of laiju extract in two different rat models.
The aim of the study was to evaluate whether laiju extract (LJE) from Semen Raphani and Flos Chrysanthemi has an anti-hypertensive effect in renal hypertensive rat (RHR) and spontaneous hypertensive rat (SHR). LJE was prepared by extracting dried Semen Raphani and Flos Chrysanthemi with 70% ethanol. RHR and SHR models were prepared by standard methods. Forty RHRs and 40 SHRs were randomly divided into high LJE (300 mg/kg), moderate LJE (200 mg/kg), low LJE (100 mg/kg) and saline control four groups (n=10), respectively. Compared with saline control, blood pressure was significantly lowered at 6 and 5 hours in high and moderate LJE respectively in both RHR and SHR groups. However, blood pressure was significantly lowered at 2 and 3 hours in low LJE in both RHR and SHR groups, respectively. Compared with saline control, blood pressure remained significantly lower in SHR in all dosage groups with a single daily dose for 28 days of study. LJE has potential in the prevention management of hypertension. Further studies are needed to identify the active chemical constituents and mechanisms of action of LJE.
Chen
Suhong
S
Academy of Traditional Chinese Medicine, Wenzhou Medical College, Wenzhou, China.
Lv
Guiyuan
G
Zhang
Xiaodong
X
Liu
Xiaoyu
X
Zhang
Han
H
Zhu
Yunwei
Y
Wu
Yin
Y
Liu
Saiyue
S
Ni
Zhunan
Z
D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006339:Heart Rate / Q000187:drug effects; D006973:Hypertension / Q000517:prevention & control*; D010936:Plant Extracts / Q000494:pharmacology*; D011897:Random Allocation; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D013997:Time Factors
D000959:Antihypertensive Agents; D010936:Plant Extracts