Photochemical control of biological processes.
Photochemical regulation of biological processes offers a high level of control to study intracellular mechanisms with unprecedented spatial and temporal resolution. This report summarizes the advances made in recent years, focusing predominantly on the in vivo regulation of gene function using irradiation with UV light. The majority of the described applications entail the utilization of photocaging groups installed either on a small molecule modulator of biomolecular function or directly on a biological macromolecule itself.
Young
Douglas D
DD
North Carolina State University, Department of Chemistry, Campus Box 8204, Raleigh, NC 27695, USA.
Deiters
Alexander
A
D004798:Enzymes / Q000235:genetics / Q000528:radiation effects*; D006801:Humans; D008027:Light; D008968:Molecular Conformation; D009930:Organic Chemicals / Q000737:chemistry / Q000528:radiation effects*; D010777:Photochemistry; D011506:Proteins / Q000235:genetics / Q000528:radiation effects*; D014466:Ultraviolet Rays
D004798:Enzymes; D009930:Organic Chemicals; D011506:Proteins