title: Restoration of cellular energetic balance with L-carnitine in the neuro-bioenergetic approach for cancer prevention and treatment.
abstract: Mitochondrial research has contributed to two paradigm shifts in oncology--Warburg's glycolytic metabolism and the relationship between mitochondrial function and mutagenesis. Mitochondrial dysfunction is a common phenotype in aging and cancer. Decline in mitochondrial function is due to the accumulation of mutations in mitochondrial DNA. We have hypothesized a neuro-bioenergetic concept in cancer prevention and treatment to constructively restore three physiological imbalances of cancer patients: membrane hyper-excitability, energy depletion and the build up of extra-cellular adenosine molecules. We have proposed the use of membrane-calming substances to reduce energy consumption and to restore the normal cellular energy metabolism. Based on our theory, L-carnitine's dual effect of enhanced energy production and excitatory neurotransmitter modulation should make it an ideal nutrient for cancer prevention and treatment. L-carnitine, its derivatives and other mitochondrial protectors/enhancers improve metabolic function, energy and detoxification. In combination with other membrane calming agents, L-carnitine could help reverse the membrane hyper-excitability to overcome a neuro-bioenergetic imbalance and can be used as a relevant and effective approach for cancer prevention and treatment.
authors: Allergy Research Group, 4010 Moorpark Ave, Ste 119, San Jose, CA 95117, USA. niscba@aol.com <niscba@aol.com>
authors: Ba X
authors: BX
authors: Hoang
authors: D
authors: D
authors: Graeme Shaw
authors: Phuong
authors: P
authors: Pham
authors: Stephen
authors: S
authors: Levine
mesh_terms: D002331:Carnitine / Q000627:therapeutic use*; D002462:Cell Membrane / Q000378:metabolism* / Q000473:pathology / Q000502:physiology; D004734:Energy Metabolism / Q000187:drug effects*; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology / Q000517:prevention & control*; D018377:Neurotransmitter Agents / Q000096:biosynthesis / Q000502:physiology*; D014803:Vitamin B Complex / Q000627:therapeutic use*
chemical_list: D018377:Neurotransmitter Agents; D014803:Vitamin B Complex; D002331:Carnitine