title: Treatment of Staphylococcus aureus biofilm infection by the quorum-sensing inhibitor RIP.
abstract: The quorum-sensing inhibitor RIP inhibits staphylococcal TRAP/agr systems and both TRAP- and agr-negative strains are deficient in biofilm formation in vivo, indicating the importance of quorum sensing to biofilms in the host. RIP injected systemically into rats has been found to have strong activity in preventing methicillin-resistant Staphylococcus aureus graft infections, suggesting that RIP can be used as a therapeutic agent.
authors: Department of Biomedical Sciences, Tufts University Cummings School of Veterinary Medicine, 200 Westboro Road, North Grafton, MA 01536, USA. naomi.balaban@tufts.edu
authors: Naomi
authors: N
authors: Balaban
authors: Oscar
authors: O
authors: Cirioni
authors: Andrea
authors: A
authors: Giacometti
authors: Roberto
authors: R
authors: Ghiselli
authors: Joel B
authors: JB
authors: Braunstein
authors: Carmela
authors: C
authors: Silvestri
authors: Federico
authors: F
authors: Mocchegiani
authors: Vittorio
authors: V
authors: Saba
authors: Giorgio
authors: G
authors: Scalise
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D018441:Biofilms / Q000187:drug effects* / Q000254:growth & development; D004195:Disease Models, Animal; D015964:Gene Expression Regulation, Bacterial; D016106:Methicillin Resistance; D009842:Oligopeptides / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use*; D016459:Prosthesis-Related Infections / Q000188:drug therapy* / Q000382:microbiology; D053038:Quorum Sensing / Q000187:drug effects*; D016601:RNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000382:microbiology; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000235:genetics / Q000254:growth & development; D015534:Trans-Activators / Q000235:genetics / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism; D016896:Treatment Outcome
chemical_list: C095698:Agr protein, Staphylococcus aureus; D001426:Bacterial Proteins; C079092:MtrB protein, Bacteria; D009842:Oligopeptides; D016601:RNA-Binding Proteins; C111711:RNAIII inhibiting peptide; D015534:Trans-Activators; D014157:Transcription Factors