COX-2 promoter region polymorphisms in multiple sclerosis: lack of association of -765G>C with disease risk.
Cyclooxygenase-2 (COX-2) is extensively expressed in multiple sclerosis lesions suggesting that regulatory variants of the COX-2 gene could be implicated in multiple sclerosis (MS). Screening of the proximal 5' regulatory region and genotyping of -765G>C and -62C>G showed that polymorphisms in this COX-2 region are unlikely to be involved in MS susceptibility.
Mazzola
S
S
Department of Mother and Child, Biology and Genetics, Section Biology and Genetics, University of Verona, Strada Le Grazie 8, 37134 Verona, Italy. mazzolasilvia@tiscali.it
Lira
M Gomez
MG
Benedetti
M D
MD
Salviati
A
A
Ottaviani
S
S
Malerba
G
G
Ortombina
M
M
Pignatti
P F
PF
D051546:Cyclooxygenase 2 / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D009103:Multiple Sclerosis / Q000201:enzymology / Q000235:genetics*; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic / Q000235:genetics; D012306:Risk
D008565:Membrane Proteins; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human