Prolonged quercetin administration diminishes the etoposide-induced DNA damage in bone marrow cells of rats.
The DNA damage in bone marrow cells induced by etoposide (E) injected intraperitoneally to rats (100 mg/kg b.w.) decreased to the control level when quercetin (Q) was administered subcutaneously for 10 consecutive days (40 mg/kg b.w.per day) before E was injected. The antioxidant power (FRAP assay) increased significantly after Q or E compared with control rats but did not change when Q preceded the E injection. The superoxide dismutase activity significantly increased in Q+E-treated rats compared with quercetin given alone. The study provides evidence that Q protects bone marrow cells against long-lived E-induced DNA damage and alters the redox balance in lung tissue.
Kapiszewska
Maria
M
Department of General Biochemistry, Faculty of Biotechnology, Jagiellonian University, Krakow, Poland. mkapisz@if.uj.edu.pl
Cierniak
Agnieszka
A
Papiez
Monika A
MA
Pietrzycka
Agata
A
Stepniewski
Marek
M
Lomnicki
Adam
A
D000818:Animals; D001854:Bone Marrow Cells / Q000187:drug effects*; D002374:Catalase / Q000378:metabolism; D020552:Comet Assay; D004249:DNA Damage / Q000187:drug effects*; D005047:Etoposide / Q000633:toxicity*; D005260:Female; D036681:Fluorescence Recovery After Photobleaching; D007279:Injections, Subcutaneous; D016014:Linear Models; D008168:Lung / Q000378:metabolism; D011794:Quercetin / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism
D005047:Etoposide; D011794:Quercetin; D002374:Catalase; D013482:Superoxide Dismutase