title: PKC blockade differentially affects aversive but not appetitive gustatory memories.
abstract: After consumption of a new taste, there are mainly two possible outcomes for the establishment of a taste memory, either it will be aversive or safe depending on the consequences of taste consumption. It has been proposed that both types of learning share a common initial taste memory trace, which will lead to two different memory traces, safe or aversive. To study the role of PKC activity in aversive or safe taste memory formation, we administered chelerythrine, a PKC inhibitor, into the insular cortex or parietal cortex 20 min before conditioned taste aversion or attenuation of neophobia training. The results suggest that PKC activity is needed in the insular cortex for the establishment of aversive taste memory, but not for safe taste memory.
authors: Departamento de Neurociencias, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Apartado Postal 70-253, 04510 México DF, Mexico.
authors: Luis
authors: L
authors: Núñez-Jaramillo
authors: Ilse
authors: I
authors: Delint-Ramirez
authors: Federico
authors: F
authors: Bermúdez-Rattoni
mesh_terms: D000470:Alkaloids / Q000009:adverse effects; D000818:Animals; D001066:Appetite / Q000187:drug effects / Q000502:physiology; D001070:Appetitive Behavior / Q000187:drug effects / Q000502:physiology*; D001362:Avoidance Learning / Q000187:drug effects / Q000502:physiology*; D053119:Benzophenanthridines / Q000009:adverse effects; D001921:Brain / Q000187:drug effects / Q000201:enzymology*; D002540:Cerebral Cortex / Q000187:drug effects / Q000201:enzymology; D004791:Enzyme Inhibitors / Q000009:adverse effects; D005247:Feeding Behavior / Q000187:drug effects / Q000502:physiology; D008568:Memory / Q000187:drug effects / Q000502:physiology*; D010296:Parietal Lobe / Q000187:drug effects / Q000201:enzymology; D011493:Protein Kinase C / Q000037:antagonists & inhibitors / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D013649:Taste / Q000187:drug effects / Q000502:physiology*
chemical_list: D000470:Alkaloids; D053119:Benzophenanthridines; D004791:Enzyme Inhibitors; C016299:chelerythrine; D011493:Protein Kinase C