title: Premotor cortex modulates somatosensory cortex during voluntary movements without proprioceptive feedback.
abstract: Movement perception relies on sensory feedback, but the involvement of efference copies remains unclear. We investigated movements without proprioceptive feedback using ischemic nerve block during fMRI in healthy humans, and found preserved activation of the primary somatosensory cortex. This activation was associated with increased interaction with premotor cortex during voluntary movements, which demonstrates that perception of movements relies in part on predictions of sensory consequences of voluntary movements that are mediated by the premotor cortex.
authors: Department of Exercise and Sport Sciences, University of Copenhagen, Blegdamsvej 3, Panum Institute 24.6, DK-2200 Copenhagen, Denmark. markc@drcmr.dk
authors: Mark Schram
authors: MS
authors: Christensen
authors: Jesper
authors: J
authors: Lundbye-Jensen
authors: Svend Sparre
authors: SS
authors: Geertsen
authors: Tue Hvass
authors: TH
authors: Petersen
authors: Olaf B
authors: OB
authors: Paulson
authors: Jens Bo
authors: JB
authors: Nielsen
mesh_terms: D000328:Adult; D001931:Brain Mapping; D004562:Electrocardiography / Q000379:methods; D005073:Evoked Potentials, Somatosensory; D005246:Feedback; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D016014:Linear Models; D008297:Male; D009044:Motor Cortex / Q000502:physiology*; D009068:Movement; D010100:Oxygen / Q000097:blood; D010775:Photic Stimulation / Q000379:methods; D011597:Psychomotor Performance; D013003:Somatosensory Cortex / Q000098:blood supply / Q000502:physiology*
chemical_list: D010100:Oxygen