Genetic admixture, adipocytokines, and adiposity in Black Americans: the Health, Aging, and Body Composition study.
Adipocytokines are a subset of cytokines produced by adipose tissue and are associated with risk of type II diabetes and atherosclerosis. Levels of adipocytokines differ between Black and White Americans, even after adjustment for differences in adiposity, diseases associated with adipocytokines including type 2 diabetes and cardiovascular disease, and general socioeconomic status indicators such as income. We used a series of ancestry informative markers to estimate genetic ancestry in a population-based study of older Black Americans, and examined the association between genetic ancestry and adipocytokines and soluble receptors to help determine which of these may be most amenable to admixture mapping. We typed 35 ancestry informative markers in 1,241 self-reported Black Americans with available DNA from the Health, Aging, and Body Composition (Health ABC) study with available DNA and used a maximum likelihood approach to estimate percent European ancestry. We used linear regression models to determine the association between these adipocytokines and percent ancestry, and staged models to examine whether adiposity or other measures affected the associations of genetic ancestry and adipocytokines. Mean European ancestry was 22.3+/-15.9%. In multivariate adjusted models, the strongest associations observed were between higher European ancestry and interleukin-6 soluble receptor (IL-6 SR), C-reactive protein (CRP), and adiponectin levels, with interleukin-2 soluble receptor (IL-2 SR) and soluble tumor necrosis factor receptor II (TNF-alpha SR II) also showing more modest but significant associations. The association with adiponectin became stronger after adjustment for adiposity. These novel findings suggest that admixture mapping may identify genetic factors influencing the levels of IL-6 SR, CRP, IL-2 SR, and adiponectin.
Wassel Fyr
Christina L
CL
Department of Epidemiology, University of Minnesota, Minneapolis, 1300 South 2nd Street, Suite 300, Minneapolis, MN 55454-1015, USA. Christina.Wassel-Fyr@ucsf.edu
Kanaya
Alka M
AM
Cummings
Steve R
SR
Reich
David
D
Hsueh
Wen-Chi
WC
Reiner
Alexander P
AP
Harris
Tamara B
TB
Moffett
Susan
S
Li
Rongling
R
Ding
Jingzhong
J
Miljkovic-Gacic
Iva
I
Ziv
Elad
E
D000273:Adipose Tissue / Q000378:metabolism; D001741:Black or African American / Q000235:genetics*; D000368:Aged; D000375:Aging / Q000235:genetics*; D001823:Body Composition / Q000235:genetics*; D016207:Cytokines / Q000235:genetics; D005260:Female; D005819:Genetic Markers; D006801:Humans; D016013:Likelihood Functions; D008297:Male
D016207:Cytokines; D005819:Genetic Markers