Radiation synovectomy with 90Y colloid in the therapy of recurrent knee joint effusions in patients with inflammatory joint diseases.
The aim of this study was to assess the effectiveness of radiation synovectomy (RSV) in the treatment of recurrent joint effusions, using 90Y in patients with chosen inflammatory joint diseases. The group of treated patients consisted of 30 people. Qualification for the treatment was based on clinical assessment, three-phase bone scintigraphy (BS3) and biochemical analysis. Intra-articular injection of 90Y was performed. Biochemical analysis was repeated after 48 h, 4 and 24 weeks, whereas BS3 was repeated after 24 weeks. Changes in the second phase of BS3 were assessed visually, using a four-degree scale and in the third phase, semiquantitatively with J/B ratio. The changes in the blood pool phase before RSV were 3.4 +/- 0.6 and after the therapy 2.00 +/- 0.8 (P < 0.001). The J/B ratio was: before RSV 2.58 +/- 08; after treatment 2.09 +/- 0.9 (P < 0.05). RSV is an effective method to treat recurrent effusions in patients with RA and SPA.
Chrapko
Beata
B
Chair and Department of Nuclear Medicine, Skubiszewski Medical University of Lublin, Jaczewskiego 8, 20-090 Lublin, Poland. beachra@o2.pl
Zwolak
Robert
R
Nocuń
Anna
A
Gołebiewska
Renata
R
Majdan
Maria
M
D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000532:radiotherapy*; D002951:Citrates / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007270:Injections, Intra-Articular; D007719:Knee Joint / Q000000981:diagnostic imaging / Q000473:pathology / Q000528:radiation effects*; D008297:Male; D008875:Middle Aged; D009942:Organometallic Compounds / Q000008:administration & dosage*; D011868:Radioisotopes / Q000008:administration & dosage*; D011877:Radionuclide Imaging; D025242:Spondylarthropathies / Q000532:radiotherapy*; D013582:Synovial Fluid / Q000528:radiation effects; D013583:Synovial Membrane / Q000000981:diagnostic imaging / Q000473:pathology / Q000528:radiation effects*; D013669:Technetium Tc 99m Medronate; D016896:Treatment Outcome
D002951:Citrates; D009942:Organometallic Compounds; D011868:Radioisotopes; C045937:yttrium citrate; D013669:Technetium Tc 99m Medronate