title: Carbohydrate status detecting by PNA is changeable through cancer prognosis from primary to metastatic nodal site: A possible prognostic factor in patient with node-positive lung adenocarcinoma.
abstract: Carbohydrates antigens in cancer cells are considered to be important molecules, which may play a critical role for metastasis. To elucidate the prognostic relevance of the expression of peanut agglutinin (PNA) binding carbohydrates in patients with lung adenocarcinoma, we investigated the PNA binding carbohydrates immunohistochemically in both of primary tumors and involving nodal lesions. A total of 62 patients with node-positive primary lung adenocarcinoma, who had undergone complete resection and regional nodes dissection were subjected to this study. There were no significant correlations between PNA staining rates and clinicopathological variables. The survival rate of patients who had positive PNA staining in both of primary tumor and nodal lesion was significantly higher than those of patients in the other groups. Furthermore, the loss of the staining rate of PNA was an independent prognostic factor beside the lymphatic vessel invasion using multivariate analysis. The expression of PNA binding carbohydrates in tumor tissue and nodal lesion would be a novel significant prognostic factor for patients with node-positive lung adenocarcinomas.
authors: First Department of Surgery, Fukushima Medical University, School of Medicine, 1 Hikarigaoka, Fukushima 960-1295, Japan. salt@fmu.ac.jp
authors: Yutaka
authors: Y
authors: Shio
authors: Hiroyuki
authors: H
authors: Suzuki
authors: Takanori
authors: T
authors: Kawaguchi
authors: Jun
authors: J
authors: Ohsugi
authors: Mitsunori
authors: M
authors: Higuchi
authors: Koichi
authors: K
authors: Fujiu
authors: Ryuzo
authors: R
authors: Kanno
authors: Akio
authors: A
authors: Ohishi
authors: Mitsukazu
authors: M
authors: Gotoh
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism* / Q000473:pathology; D017677:Age Distribution; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000556:secondary / Q000601:surgery; D008198:Lymph Nodes / Q000378:metabolism* / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009361:Neoplasm Invasiveness; D019887:Peanut Agglutinin / Q000378:metabolism*; D011379:Prognosis; D016019:Survival Analysis
chemical_list: D015295:Antigens, Tumor-Associated, Carbohydrate; D019887:Peanut Agglutinin