title: Long-term follow-up of patients with multiple endocrine neoplasia type 1.
abstract: Whether early surgical treatment of non-functioning pancreas islet cell tumor (NFPT) provides a favorable quality of life and life expectancy in patients with multiple endocrine neoplasia type 1 (MEN1) remains controversial. We analyzed the long-term clinical courses and surgical outcomes of 14 Japanese patients with MEN1-associated NFPTs. NFPTs smaller than 20 mm in diameter did not show any apparent growth over a long monitoring period. Furthermore, these small NFPTs did not metastasize to regional lymph nodes or the liver. On the other hand, the development of additional NFPTs or metastasis was found in five of six patients with large (35 mm or larger) NFPTs. Among the seven patients who underwent a partial pancreatectomy, six patients developed impaired glucose tolerance or diabetes. The accumulation of more prospective data is needed to clarify the optimal surgical indications for patients with NFPTs, especially among the Japanese population, which has a relatively low insulin secretion potency compared with non-Hispanic white and African-American populations.
authors: Department of Aging Medicine and Geriatrics, Shinshu University Graduate School of Medicine, Japan.
authors: Akihiro
authors: A
authors: Sakurai
authors: Miyuki
authors: M
authors: Katai
authors: Koh
authors: K
authors: Yamashita
authors: Jun-Ichiro
authors: J
authors: Mori
authors: Yoshimitsu
authors: Y
authors: Fukushima
authors: Kiyoshi
authors: K
authors: Hashizume
mesh_terms: D007516:Adenoma, Islet Cell / Q000000981:diagnostic imaging / Q000209:etiology* / Q000503:physiopathology / Q000601:surgery*; D000328:Adult; D044466:Asian People; D003920:Diabetes Mellitus / Q000209:etiology; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D018149:Glucose Intolerance / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D018761:Multiple Endocrine Neoplasia Type 1 / Q000150:complications* / Q000208:ethnology; D009362:Neoplasm Metastasis; D016609:Neoplasms, Second Primary / Q000000981:diagnostic imaging; D010179:Pancreas / Q000503:physiopathology; D010180:Pancreatectomy / Q000009:adverse effects / Q000379:methods; D010190:Pancreatic Neoplasms / Q000000981:diagnostic imaging / Q000209:etiology* / Q000503:physiopathology / Q000601:surgery*; D014057:Tomography, X-Ray Computed