title: Multivesicular emulsion: a novel, controlled-release delivery system for topical dermatological agents.
abstract: Multivesicular emulsion systems are a new patented technology for topical delivery of pharmaceutical and over-the-counter actives. This novel technology involves the creation of a 2-phase, oil-in-water emulsion system that produces concentric multilamellar spheres of oil and water. Active ingredients can be released from their respective layers upon application to the skin. In addition to a controlled-release of active agents, the multivesicular emulsion base improves the biophysical properties of the skin by reducing transepidermal water loss and enhancing skin hydration. This technology has been applied to 6% salicylic acid formulations that in clinical experience show efficacy with high tolerance in several hyperkeratotic disorders. Subjects' self-assessment was clearly indicative of the excellent cosmetic elegance of the multivesicular emulsion system.
authors: Bikowski Skin Care Center, Sewickley, PA, USA.
authors: Joseph
authors: J
authors: Bikowski
authors: Braham
authors: B
authors: Shroot
mesh_terms: D000279:Administration, Cutaneous; D003692:Delayed-Action Preparations / Q000008:administration & dosage* / Q000493:pharmacokinetics; D003879:Dermatologic Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D004655:Emulsions / Q000008:administration & dosage* / Q000493:pharmacokinetics; D006801:Humans; D013678:Technology, Pharmaceutical / Q000379:methods / Q000639:trends
chemical_list: D003692:Delayed-Action Preparations; D003879:Dermatologic Agents; D004655:Emulsions