Effect of nicotine on neuromuscular transmission in mouse motor synapses.
Nicotine (10 nM) inhibits rhythmic activity of the neuromuscular synapse in mice. This effect was prevented by alpha-cobratoxin and apamin. Hence, the effects of nicotine are realized via presynaptic neuronal nicotinic cholinoceptors and Ca(2+)-activated potassium channels.
Balezina
O P
OP
Department of Human and Animal Physiology, Biological Faculty, M. V. Lomonosov Moscow State University. balezina@mail.ru
Fedorin
V V
VV
Gaidukov
A E
AE
D000818:Animals; D001030:Apamin / Q000633:toxicity*; D003039:Cobra Neurotoxin Proteins / Q000633:toxicity*; D003964:Diaphragm / Q000166:cytology / Q000187:drug effects; D019054:Evoked Potentials, Motor / Q000187:drug effects / Q000502:physiology; D051379:Mice; D009045:Motor Endplate / Q000502:physiology; D009469:Neuromuscular Junction / Q000187:drug effects* / Q000502:physiology; D009538:Nicotine / Q000037:antagonists & inhibitors* / Q000494:pharmacology*; D024681:Potassium Channels, Calcium-Activated / Q000378:metabolism; D011950:Receptors, Cholinergic / Q000378:metabolism
D003039:Cobra Neurotoxin Proteins; D024681:Potassium Channels, Calcium-Activated; D011950:Receptors, Cholinergic; D001030:Apamin; C025154:alpha-cobratoxin; D009538:Nicotine