title: Sesquiterpene lactones from Saussurea alata.
abstract: Two new guaianolides, namely, 3beta,8alpha-dihydroxy-13-methoxyl-4(14),10(15)-dien-(1alphaH,5alphaH,6beta H,11betaH)-12,6-olide (1) and 3beta,8alpha-dihydroxy-13-methoxyl-4(14),10(15)-dien-(1alphaH,5alphaH,6beta H,11alphaH)-12,6-olide (2), together with six known guaianolides, 8-hydroxyzaluzanin C, austricin, chlorojanerin, cynaropicrin, chlorohyssopifolin E and chlorohyssopifolin A were isolated from the aerial parts of Saussurea alata. The structures were established mainly based on spectral analysis, especially 2D NMR techniques.
authors: Research Centre of Siyuan Natural Pharmacy and Bio-toxicity, College of Life Sciences, Zhejiang University, Hangzhou 310058, China.
authors: G
authors: G
authors: Ren
authors: Z M
authors: ZM
authors: Yu
authors: Y L
authors: YL
authors: Chen
authors: S H
authors: SH
authors: Wu
authors: C X
authors: CX
authors: Fu
mesh_terms: D004354:Drug Screening Assays, Antitumor; D005260:Female; D006367:HeLa Cells; D006801:Humans; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification; D013058:Mass Spectrometry; D008958:Models, Molecular; D008968:Molecular Conformation; D030441:Saussurea / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification; D045789:Sesquiterpenes, Guaiane / Q000737:chemistry* / Q000302:isolation & purification; D013055:Spectrophotometry, Infrared; D013237:Stereoisomerism
chemical_list: C519440:3beta,8alpha-dihydroxy-13-methoxyl-4(14),10(15)-dien-(1alphaH,5alphaH,6beta H,11betaH)-12,6-olide; D007783:Lactones; D012717:Sesquiterpenes; D045789:Sesquiterpenes, Guaiane