Transmission of mitochondrial DNA disorders: possibilities for the elimination of mutated mitochondria.
The recent article by D.T. Brown et al. (2006) discusses the transmission of mitochondrial DNA disorders. In the second part, the authors describe certain techniques that can be potentially used to eliminate the transmission of mutated mtDNA from mother to offspring. It is our opinion that this brief account needs broader explanation. Moreover, some approaches mentioned are not always correctly interpreted.
Fulka
Josef
J
Center for Cell Therapy and Tissue Repair, VUZV Labs., Prague, Czech Republic. fulka@vuzv.cz
Fulka
Helena
H
John
Justin C St
JC
D004272:DNA, Mitochondrial / Q000235:genetics*; D030342:Genetic Diseases, Inborn / Q000235:genetics* / Q000628:therapy*; D015316:Genetic Therapy; D006801:Humans; D028361:Mitochondrial Diseases / Q000235:genetics* / Q000628:therapy*; D009154:Mutation
D004272:DNA, Mitochondrial