title: Straightforward stereoselective synthesis of spiro-epoxyoxindoles.
abstract: [reaction: see text] The in situ preparation of a sulfonium ylide reagent achieved the highly diastereoselective epoxidation of isatins, so that a new and straightforward access to biologically significant spiro-epoxyoxindoles is provided. The first investigations of an asymmetric version are reported with enantiopure sulfides.
authors: Laboratoire de Chimie Moléculaire et Thio-organique (UMR CNRS 6507), ENSICAEN Université de Caen, 6 Boulevard du Maréchal Juin, 14050 Caen, France.
authors: Verena
authors: V
authors: Schulz
authors: Marion
authors: M
authors: Davoust
authors: Margareth
authors: M
authors: Lemarié
authors: Jean-François
authors: JF
authors: Lohier
authors: Jana Sopkova de Oliveira
authors: JS
authors: Santos
authors: Patrick
authors: P
authors: Metzner
authors: Jean-François
authors: JF
authors: Brière
mesh_terms: D004852:Epoxy Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D007211:Indoles / Q000138:chemical synthesis / Q000737:chemistry*; D015394:Molecular Structure; D000078183:Oxindoles; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D004852:Epoxy Compounds; D007211:Indoles; D000078183:Oxindoles; D013141:Spiro Compounds; C022960:2-oxindole; C095912:N-methylisatin