title: Mass spectrometric detection of and similarities between 1-androgens.
abstract: Regularly new anabolic steroids appear on the black market. In most cases these substances are marketed on websites or are confiscated during inspections. 1,(5alpha)-Androstene-17beta-ol-3-one, also known as 1-testosterone, is one of these substances presented to body-builders as a nutritional supplement or a pro-hormone. 1-Testosterone closely resembles the natural hormone testosterone except for a 1,2-double bound instead of a 4,5-double bound. 1-Androstene-3beta,17beta-diol is transformed into 1-testosterone after oral administration. 1-Testosterone, 1-androstene-3beta,17beta-diol and some other related 'new' anabolic steroids were studied with gas chromatography coupled to mass spectrometry (GC-MS) and Liquid chromatography coupled to tandem mass spectrometry (LC-MS2) methods. Similarities in spectra to known analytes, which may lead to pitfalls in the interpretation of the derivatised analytes, are discussed.
authors: Ghent University, Faculty of Veterinary Medicine, Department of Veterinary Public Health and Food Safety, Laboratory of Chemical Analysis, Salisburylaan 133, B-9820 Merelbeke, Belgium.
authors: K
authors: K
authors: Verheyden
authors: B
authors: B
authors: Le Bizec
authors: D
authors: D
authors: Courtheyn
authors: V
authors: V
authors: Mortier
authors: M
authors: M
authors: Vandewiele
authors: W
authors: W
authors: Gillis
authors: P
authors: P
authors: Vanthemsche
authors: H F
authors: HF
authors: De Brabander
authors: H
authors: H
authors: Noppe
mesh_terms: D000284:Administration, Oral; D045930:Anabolic Agents / Q000032:analysis*; D000728:Androgens / Q000032:analysis*; D015114:Androstenediol / Q000032:analysis; D002849:Chromatography, Gas / Q000379:methods*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D002853:Chromatography, Liquid / Q000379:methods*; D004300:Doping in Sports; D008401:Gas Chromatography-Mass Spectrometry; D013058:Mass Spectrometry / Q000379:methods*; D008956:Models, Chemical; D013256:Steroids / Q000032:analysis*; D015813:Substance Abuse Detection / Q000379:methods; D013739:Testosterone / Q000031:analogs & derivatives* / Q000032:analysis* / Q000737:chemistry; D014891:Weight Lifting
chemical_list: D045930:Anabolic Agents; D000728:Androgens; D013256:Steroids; D013739:Testosterone; D015114:Androstenediol; C520094:1-testosterone