title: The introduction of variolation 'A La Turca' to the West by Lady Mary Montagu and Turkey's contribution to this.
abstract: OBJECTIVE
  This study deals with the history of variolation as the oldest immunization method to be transferred from East to West, with emphasis on Turkey's role in this transmission.
  
  
  METHODS
  The technique of variolation was used by various ancient civilizations such as those in India, Tibet and many other parts of Asia. It was based on the subcutaneous inoculation of attenuated pustule material in patients. The method was brought to Anatolia by the Seljuks through the Caucasus and was widely used by the Ottomans for a long period of time. The West learned of this method for the first time mainly through the writings of Dr. Timoni and Lady Mary W. Montagu in the 18th century. Lady Montagu not only wrote letters explaining this method, but also worked actively to introduce it in Europe.
  
  
  CONCLUSIONS
  Since variolation carried the risk of infection, it was replaced by a safer method called vaccination discovered by Jenner (1789), which led to the eradication of smallpox from the world. Despite the fact that vaccination ultimately superseded variolation in Western medical practice, Turkey played a key role as a bridge between civilizations in the transfer of this earlier treatment method to the West.
authors: Istanbul University, Cerrahpasa Faculty of Medicine, Department of Medical History and Ethics, Istanbul, Turkey. gultendinc@yahoo.com
authors: Gulten
authors: G
authors: Dinc
authors: Yesim Isil
authors: YI
authors: Ulman
mesh_terms: D049671:History, 18th Century; D006801:Humans; D007114:Immunization / Q000266:history*; D012899:Smallpox / Q000276:immunology / Q000517:prevention & control*; D014421:Turkey