Combined administration of NAN-190 and 17beta-estradiol abolishes the amnesic effect of scopolamine in middle-aged ovariectomized rats.
Chronic combined administration of 5-HT1A receptor antagonist NAN-190 and 17beta-estradiol improved conditioned passive avoidance performance in middle-aged ovariectomized rats with scopolamine-induced amnesia. Our results suggest that the ovarian hormonal, cholinergic, and serotoninergic systems play a role in age-related cognitive disturbances under conditions of hypoestrogenic syndrome.
Sapronov
N S
NS
S. V. Anichkov Department of Neuropharmacology, Institute of Experimental Medicine, Russian Academy of Medical Sciences, St. Petersburg.
Fedotova
Yu O
YO
Losev
N A
NA
D000647:Amnesia / Q000139:chemically induced* / Q000188:drug therapy*; D000704:Analysis of Variance; D000818:Animals; D004338:Drug Combinations; D004958:Estradiol / Q000627:therapeutic use*; D005260:Female; D010052:Ovariectomy; D010879:Piperazines / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D012601:Scopolamine / Q000009:adverse effects*
D004338:Drug Combinations; D010879:Piperazines; C058895:1-(2-methoxyphenyl)-4-(4-(2-phthalimido)butyl)piperazine; D004958:Estradiol; D012601:Scopolamine