title: Toward a multiscale model of antigen presentation in immunity.
abstract: A functioning immune system and the process of antigen presentation in particular encompass events that occur at multiple length and time scales. Despite a wealth of information in the biological literature regarding each of these scales, no single representation synthesizing this information into a model of the overall immune response as it depends on antigen presentation is available. In this article, we outline an approach for integrating information over relevant biological and temporal scales to generate such a representation for major histocompatibility complex class II-mediated antigen presentation. In addition, we begin to address how such models can be used to answer questions about mechanisms of infection and new strategies for treatment and vaccines.
authors: Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA. kirschne@umich.edu
authors: Denise E
authors: DE
authors: Kirschner
authors: Stewart T
authors: ST
authors: Chang
authors: Thomas W
authors: TW
authors: Riggs
authors: Nicolas
authors: N
authors: Perry
authors: Jennifer J
authors: JJ
authors: Linderman
mesh_terms: D000818:Animals; D017951:Antigen Presentation; D000938:Antigen-Presenting Cells / Q000276:immunology*; D000949:Histocompatibility Antigens Class II / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular; D018448:Models, Immunological
chemical_list: D000949:Histocompatibility Antigens Class II