Reactome: a knowledge base of biologic pathways and processes.
Reactome http://www.reactome.org, an online curated resource for human pathway data, provides infrastructure for computation across the biologic reaction network. We use Reactome to infer equivalent reactions in multiple nonhuman species, and present data on the reliability of these inferred reactions for the distantly related eukaryote Saccharomyces cerevisiae. Finally, we describe the use of Reactome both as a learning resource and as a computational tool to aid in the interpretation of microarrays and similar large-scale datasets.
Vastrik
Imre
I
European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK. vastrik@ebi.ac.uk
D'Eustachio
Peter
P
Schmidt
Esther
E
Joshi-Tope
Geeta
G
Gopinath
Gopal
G
Croft
David
D
de Bono
Bernard
B
Gillespie
Marc
M
Jassal
Bijay
B
Lewis
Suzanna
S
Matthews
Lisa
L
Wu
Guanming
G
Birney
Ewan
E
Stein
Lincoln
L
D000818:Animals; D019295:Computational Biology / Q000379:methods*; D019992:Databases as Topic; D006801:Humans; D020407:Internet; D051188:Knowledge Bases; D053858:Metabolic Networks and Pathways; D046228:Microarray Analysis; D012441:Saccharomyces cerevisiae; D049490:Systems Biology