title: Angiographic and clinical outcome following sirolimus-eluting stent (Cypher) implantation. A single center experience.
abstract: OBJECTIVE
  To investigate the late outcomes of sirolimus-eluting stent implantation in patients with coronary artery disease.
  
  
  BACKGROUND
  Drug-eluting stents reduce intimal hyperplasia, which is the main cause of in-stent restenosis. Sirolimus-eluting stents significantly reduce clinical and angiographic restenosis and improve event-free survival.
  
  
  METHODS
  The study population consisted of 207 patients (273 stents) who had undergone coronary Cypher stent implantation. Patients were eligible for enrollment if there was symptomatic coronary artery disease or positive exercise testing, and angiographic evidence of single or multivessel disease with a target lesion stenosis of > or = 70% in a > or = 2.25 mm vessel. Follow-up coronary angiography was performed 18 months after stent deployment. Patients were followed-up for a mean of 24.7 +/- 7.4 months.
  
  
  RESULTS
  All patients survived after stent implantation, but 5 (2.4%) patients experienced acute ST elevation myocardial infarction and 4 (1.9%) patients developed non-Q wave myocardial infarction following angioplasty. Recurrent angina pectoris was observed in 16 (7.7%) patients (11 stable angina pectoris and 5 unstable angina pectoris). Angiographic evidence of restenosis was observed in these 20 (9.66%) patients. The 5 other patients had noncritical angiographic restenosis. Eleven (5.3%) patients underwent angioplasty because of restenosis, and coronary artery bypass grafting was conducted in the other 9 (4.3%) patients.
  
  
  CONCLUSIONS
  The results of the present study indicate that Cypher stents could be implanted with a very high success rate and have encouraging long-term angiographic and clinical results.
authors: Department of Cardiology, Faculty of Medicine, Mersin University, Mersin, Turkey.
authors: Turkay
authors: T
authors: Ozcan
authors: V Gokhan
authors: VG
authors: Cin
authors: Mustafa
authors: M
authors: Yurtdas
authors: Burak
authors: B
authors: Akcay
authors: Sabri
authors: S
authors: Seyis
authors: Armagan
authors: A
authors: Acele
authors: Dilek
authors: D
authors: Cicek
authors: Ahmet
authors: A
authors: Camsari
authors: Necdet
authors: N
authors: Akkus
authors: Oben
authors: O
authors: Doven
mesh_terms: D000787:Angina Pectoris / Q000000981:diagnostic imaging / Q000601:surgery*; D019917:Blood Vessel Prosthesis Implantation / Q000295:instrumentation*; D020099:Coated Materials, Biocompatible; D017023:Coronary Angiography; D023903:Coronary Restenosis / Q000000981:diagnostic imaging / Q000401:mortality / Q000517:prevention & control*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009204:Myocardial Revascularization / Q000379:methods; D011379:Prognosis; D020123:Sirolimus / Q000627:therapeutic use*; D015607:Stents; D015996:Survival Rate; D014421:Turkey / Q000453:epidemiology
chemical_list: D020099:Coated Materials, Biocompatible; D007166:Immunosuppressive Agents; D020123:Sirolimus