title: Possible involvement of the tip of temporal lobe in Landau-Kleffner syndrome.
abstract: Landau-Kleffner syndrome (LKS) is a childhood disorder of unknown etiology characterized by an acquired aphasia and epilepsy. We have performed comprehensive neurofunctional studies on an 8-year-old girl with typical LKS, with the aim of identifying lesions that may be responsible for her condition. 18F-fluoro-D-glucose (FDG) positron emission computed tomography (PET), 11C-Flumazenil (FMZ) PET, 99mTc-hexamethylpropyleneamine oxime single photon emission computed tomography (SPECT) and magnetoencephalography were performed before and after changes to the patient's medication led to a clinical improvement. Interictal SPECT showed hypoperfusion in the left frontal, left temporal, and left occipital lobes. 18F-FDG PET demonstrated a decrease in glucose metabolism medially in both temporal lobes and superiorly in the left temporal lobe. 11C-FMZ PET revealed a deficit in benzodiazepine receptor binding at the tip of the left temporal lobe. Magnetoencephalography demonstrated equivalent current dipoles located superiorly in the left temporal lobe. Our results suggest that the tip of the left temporal lobe plays an important role in the pathogenesis of LKS in our patient.
authors: Department of Pediatrics, Hokkaido University, Graduate School of Medicine, North 15, West 7, Kita-ku, Sapporo, Hokkaido 060-8638, Japan. siraisi@med.hokudai.ac.jp
authors: Hideaki
authors: H
authors: Shiraishi
authors: Kyoko
authors: K
authors: Takano
authors: Tohru
authors: T
authors: Shiga
authors: Maki
authors: M
authors: Okajima
authors: Akira
authors: A
authors: Sudo
authors: Naoko
authors: N
authors: Asahina
authors: Shinobu
authors: S
authors: Kohsaka
authors: Masakazu
authors: M
authors: Fukuhara
authors: Shinji
authors: S
authors: Saitoh
mesh_terms: D000927:Anticonvulsants / Q000627:therapeutic use; D002648:Child; D004569:Electroencephalography; D005260:Female; D006801:Humans; D018887:Landau-Kleffner Syndrome / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology*; D008279:Magnetic Resonance Imaging; D015225:Magnetoencephalography; D049268:Positron-Emission Tomography; D012640:Seizures / Q000188:drug therapy / Q000209:etiology; D019690:Technetium Tc 99m Exametazime; D013702:Temporal Lobe / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology*; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D000927:Anticonvulsants; D019690:Technetium Tc 99m Exametazime