Lysophospholipid receptors in cell signaling.
There is increasing evidence that different phospholipids are involved in regulation of various cell processes and cell-cell interactions. Lysophospholipids (lysophosphatidic acid, lysophosphatidylcholine) and a number of lysosphingolipids play particular roles in these regulations. Their effects are mediated by specific G-protein-coupled receptors. G-Protein coupled signal transduction to the cell nucleus involving a chain of intracellular protein kinases induces the main effects in cells--growth, proliferation, survival, or apoptosis. This review summarizes recent data on various groups of lysophospholipid receptors and their cell signal transduction pathways.
Torkhovskaya
T I
TI
Institute of Physico-Chemical Medicine, Moscow, Russia. torti@mail.ru
Ipatova
O M
OM
Zakharova
T S
TS
Kochetova
M M
MM
Khalilov
E M
EM
D005260:Female; D006801:Humans; D008246:Lysophospholipids / Q000378:metabolism; D008297:Male; D008954:Models, Biological; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism; D049312:Receptors, Lysophospholipid / Q000378:metabolism*; D015398:Signal Transduction; D013110:Sphingosine / Q000031:analogs & derivatives / Q000378:metabolism
D008246:Lysophospholipids; D043562:Receptors, G-Protein-Coupled; D049312:Receptors, Lysophospholipid; C060506:sphingosine 1-phosphate; D013110:Sphingosine; C032881:lysophosphatidic acid