title: Clinicopathological significance of BGP expression in non-small-cell lung carcinoma: relationship with histological type, microvessel density and patients' survival.
abstract: OBJECTIVE
  Brain-type glycogen phosphorylase (BGP) is the major isoform of glycogen phosphorylase found in fetal and neoplastic tissues, and is generally thought to induce glucose supply during an ischaemic period. This study was performed to investigate BGP expression in non-small-cell lung carcinoma (NSCLC).
  
  
  METHODS
  A total of 119 cases of NSCLC, including 63 squamous cell carcinomas (SqCCs) and 56 adenocarcinomas (ACs), were imunohistochemically evaluated for BGP expression, and its expression was correlated with clinicopathological parameters.
  
  
  RESULTS
  In total, 76.5% were positive, while non-neoplastic bronchial epithelial cells were weakly positive and pneumocytes were negative. High BGP expression was noted in 78.6% of ACs and 36.5% of SqCCs (p=0.001). Microvessel density was higher in the low BGP expression tumours (29.6 +/- 16.9/mm(2)) than in the high expression tumours (22.8+/-13.8/mm(2)) (p=0.017). BGP expression did not correlate with patient age or tumour stage, but was more frequent in females than males. Kaplan-Meier analysis showed that high BGP expression was associated with poorer survival (p=0.032).
  
  
  CONCLUSIONS
  BGP is expressed in NSCLC, particularly AC, and is an independent poor prognostic factor.
authors: Medical Research Institute, Department of lnternal Medicine, College of Medicine, Pusan National University, Busan, Korea.
authors: Min Ki
authors: MK
authors: Lee
authors: Jae Ho
authors: JH
authors: Kim
authors: Chang Hun
authors: CH
authors: Lee
authors: Jong Min
authors: JM
authors: Kim
authors: Chi Duk
authors: CD
authors: Kang
authors: Young Dae
authors: YD
authors: Kim
authors: Kyung Un
authors: KU
authors: Choi
authors: Hwal Woong
authors: HW
authors: Kim
authors: Jee Yeon
authors: JY
authors: Kim
authors: Do Youn
authors: DY
authors: Park
authors: Mee Young
authors: MY
authors: Sol
mesh_terms: D000230:Adenocarcinoma / Q000098:blood supply / Q000401:mortality / Q000473:pathology; D000328:Adult; D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung / Q000098:blood supply* / Q000401:mortality / Q000473:pathology*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D025002:Glycogen Phosphorylase, Brain Form / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D053208:Kaplan-Meier Estimate; D008168:Lung / Q000098:blood supply / Q000378:metabolism / Q000473:pathology; D008175:Lung Neoplasms / Q000098:blood supply* / Q000401:mortality / Q000473:pathology*; D008297:Male; D008833:Microcirculation; D008875:Middle Aged; D011379:Prognosis; D012727:Sex Characteristics; D015996:Survival Rate
chemical_list: D025002:Glycogen Phosphorylase, Brain Form