[The features of pathology and immunohistochemistry in orbital meningiomas].
OBJECTIVE
To study the biological characteristics of orbital meningiomas using histological and immunohistochemistrical analysis.


METHODS
19 specimens taking from orbital meningiomas were included in the study. HE staining was used for histology analysis and the immunohistochemistry was applied to demonstrate the expression of Vimentin, EMA, Ki-67, p53 in the tissue of orbital meningiomas.


RESULTS
The main configuration of orbital meningiomas was meningothelial, transitional and fibrous meningioma. The expression rations of Vimentin and EMA were 94.75% (18/19), 52.63% (10/19), respectively. The detected rations of Ki-67 and p53 were very lower.


CONCLUSIONS
Our study shows that the major histological configuration of orbital meningiomas are meningothelial, transitional and fibrous meningioma. Compare with intracranial meningiomas, the expression rate of EMA in orbital meningiomas is lower. No difference of the expression rates of p53 and Ki-67 are found in benignant, recrudescent and malignant of tumor.
Hei
Yan
Y
Institute of Orbital Disease, Armed Police General Hospital, Beijing 100039, China. heiyan842@yahoo.com.cn
Zhang
Xin-wu
XW
Wang
Yi
Y
Lu
Xiao-zhong
XZ
Yang
Xin-ji
XJ
Xiao
Li-hua
LH
D000328:Adult; D005260:Female; D006801:Humans; D019394:Ki-67 Antigen / Q000378:metabolism; D008297:Male; D008579:Meningioma / Q000378:metabolism / Q000473:pathology*; D008875:Middle Aged; D018396:Mucin-1 / Q000378:metabolism; D009918:Orbital Neoplasms / Q000378:metabolism / Q000473:pathology*; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism; D014746:Vimentin / Q000378:metabolism; D055815:Young Adult
D019394:Ki-67 Antigen; D018396:Mucin-1; D016159:Tumor Suppressor Protein p53; D014746:Vimentin