title: Antimicrobial susceptibility of invasive pneumococcal isolates from a region in south-west Sweden 1998-2001.
abstract: Invasive disease caused by antibiotic resistant pneumococci is a worldwide problem. All invasive pneumococcal strains in an area of south-west Sweden with 1.7 million inhabitants were collected prospectively during 1998-2001. Minimum inhibitory concentrations (MICs) were determined by E-test and correlated to serotypes and clinical characteristics. Of 827 strains, 744 (90%) were susceptible (S) to all agents tested and 83 (10%) were indeterminate (I) or resistant (R) to at least 1 agent. 22 isolates (2.7%) were I to penicillin (MIC >0.06 to < or = 1.0 mg/l), but none were R (MIC >1.0 mg/l). Numbers and proportions of decreased susceptibility against other agents tested were as follows: erythromycin R: 30 (3.6%), clindamycin R: 6 (0.7%), tetracycline R: 16 (1.9%), moxifloxacin R: 1 (0.1%), cotrimoxazole I: 17 (2%) and R: 31(4%). Non-susceptibility to at least 1 agent was not correlated with age, clinical manifestation, underlying diseases and outcome. The serotype distribution differed between non-susceptible and susceptible strains. The serotypes in the 7-valent pneumococcal conjugate vaccine covered 42% of all infections and 73% of those caused by non-susceptible strains. In conclusion, the impact of antibiotic resistance in invasive pneumococcal disease remains limited in south-west Sweden.
authors: Department of Infectious Diseases, Skaraborg Hospital, Skövde, Sweden. erik.backhaus@vgregion.se
authors: Erik
authors: E
authors: Backhaus
authors: Stefan
authors: S
authors: Berg
authors: Birger
authors: B
authors: Trollfors
authors: Rune
authors: R
authors: Andersson
authors: Elisabet
authors: E
authors: Persson
authors: Berndt E B
authors: BE
authors: Claesson
authors: Peter
authors: P
authors: Larsson
authors: Elisabeth
authors: E
authors: Ek
authors: Lars
authors: L
authors: Jonsson
authors: Gunilla
authors: G
authors: Rådberg
authors: Siv
authors: S
authors: Johansson
authors: Torvald
authors: T
authors: Ripa
authors: Diana
authors: D
authors: Karlsson
authors: Kerstin
authors: K
authors: Andersson
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D024881:Drug Resistance, Bacterial; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008826:Microbial Sensitivity Tests / Q000706:statistics & numerical data; D008875:Middle Aged; D010406:Penicillins / Q000494:pharmacology; D011008:Pneumococcal Infections / Q000188:drug therapy / Q000453:epidemiology*; D013296:Streptococcus pneumoniae / Q000187:drug effects / Q000472:pathogenicity*; D013548:Sweden / Q000453:epidemiology
chemical_list: D010406:Penicillins