title: Duloxetine pharmacokinetics are similar in Japanese and Caucasian subjects.
abstract: OBJECTIVE
  To compare single- and multiple-dose duloxetine pharmacokinetics between healthy Japanese and Caucasians.
  
  
  METHODS
  Twenty-four subjects of each race were given single oral doses of duloxetine (20, 40 and 60 mg) in a randomized, double-blind study. Another 20 subjects of each race received 20, 40 mg or placebo (2 : 2 : 1) twice-daily for 5 days.
  
  
  RESULTS
  Following single doses, the mean duloxetine C(max) and AUC were approximately 20% greater in Japanese. This difference could be explained by the 15% lower average body weight in Japanese. Similar results were observed following multiple dosing.
  
  
  CONCLUSIONS
  Duloxetine pharmacokinetics are not meaningfully different between Japanese and Caucasians.
authors: Lilly-NUS Centre for Clinical Pharmacology, National University of Singapore, Singapore. clark_chan@lilly.com
authors: Clark
authors: C
authors: Chan
authors: Kwee P
authors: KP
authors: Yeo
authors: Alan X
authors: AX
authors: Pan
authors: Maggie
authors: M
authors: Lim
authors: Mary P
authors: MP
authors: Knadler
authors: David S
authors: DS
authors: Small
mesh_terms: D000928:Antidepressive Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D044466:Asian People; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D000068736:Duloxetine Hydrochloride; D006801:Humans; D013876:Thiophenes / Q000008:administration & dosage / Q000493:pharmacokinetics*; D044465:White People
chemical_list: D000928:Antidepressive Agents; D013876:Thiophenes; D000068736:Duloxetine Hydrochloride