Staphylococcus aureus strains that are hypersusceptible to resistance gene transfer from enterococci.
We identified naturally occurring Staphylococcus aureus mutants of the restriction modification pathway SauI, including bovine lineage ST151. In a model of vancomycin resistance transfer from Enterococcus faecalis, ST151 isolates are 500 times more susceptible than human S. aureus isolates. The eradication of "hyperrecipient" strains may reduce the evolution of vancomycin-resistant S. aureus.
Sung
Julia M-L
JM
Department of Cellular and Molecular Medicine, St. George's, University of London, Cranmer Tce, London SW17 0RE, United Kingdom. jlindsay@sgul.ac.uk
Lindsay
Jodi A
JA
D000818:Animals; D002417:Cattle; D003227:Conjugation, Genetic; D015252:Deoxyribonucleases, Type II Site-Specific / Q000235:genetics; D016983:Enterococcus / Q000187:drug effects / Q000235:genetics*; D005260:Female; D022761:Gene Transfer, Horizontal; D006801:Humans; D008414:Mastitis, Bovine / Q000382:microbiology; D008969:Molecular Sequence Data; D009154:Mutation; D017422:Sequence Analysis, DNA; D013203:Staphylococcal Infections / Q000382:microbiology / Q000662:veterinary; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000235:genetics* / Q000302:isolation & purification; D020713:Vancomycin Resistance / Q000235:genetics*
D015252:Deoxyribonucleases, Type II Site-Specific; C062194:endodeoxyribonuclease SauI