Early tumor regression following severe lung injury after allogeneic stem cell transplantation in a patient with renal cell carcinoma.
We describe a 65-year-old man who had repeated lung injuries after reduced-intensity allogeneic stem cell transplantation (RIST) for renal cell carcinoma. Severe pneumonitis developed twice at the time of neutrophil recovery and acute graft-versus-host disease. Both episodes were successfully treated with steroid pulse therapy. Metastases regressed after the first episode and were stable during these lung disorders, but he died of tumor progression 6 months after RIST. This case suggests that certain local inflammatory reactions may be associated with an anti-tumor effect.
Hoshino
Natsuki
N
Department of Hematology and Oncology, Mie University School of Medicine, Mie.
Nakase
Kazunori
K
Tawara
Isao
I
Kageyama
Shinichi
S
Ohishi
Kohshi
K
Nishii
Kazuhiro
K
Sugimura
Yoshiki
Y
Shiku
Hiroshi
H
Katayama
Naoyuki
N
D000368:Aged; D002292:Carcinoma, Renal Cell / Q000473:pathology / Q000628:therapy*; D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology / Q000628:therapy*; D008297:Male; D011859:Radiography; D012074:Remission Induction; D012128:Respiratory Distress Syndrome / Q000000981:diagnostic imaging / Q000209:etiology* / Q000628:therapy; D033581:Stem Cell Transplantation / Q000009:adverse effects*; D013899:Thoracic Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary / Q000628:therapy; D016896:Treatment Outcome