title: Comparison of implicit memory encoding paradigms for the activation of mediotemporal structures.
abstract: The medial temporal lobes (MTLs) are essential for both encoding and retrieval processes in declarative memory. In addition, they are a frequent seizure focus for medically refractory epilepsy. One of the major side effects of MTL resection is a decline in memory functions. Most functional imaging paradigms have been developed to find preoperative measures that, to obtain a prognosis of postoperative memory performance, employ explicit memory encoding strategies to elicit MTL activation, and require a great amount of cognitive effort. We applied three different implicit encoding tasks, which require less effort and time, to a group of healthy subjects. We found left-lateralized activation for verbal stimuli, bilateral activation for pictures, and right-lateralized activation for faces. The present study shows that even with an implicit memory-encoding paradigm, a lateralized activation of MTL structures can be achieved. This may lead to paradigms for routine clinical application that require less cognitive effort and time on the part of patients.
authors: Department of Epileptology, University of Bonn, Sigmund Freud-Strasse 25, D-53105 Bonn, Germany. bernd.weber@ukb.uni-bonn.de
authors: Bernd
authors: B
authors: Weber
authors: Frank
authors: F
authors: Kügler
authors: Christian E
authors: CE
authors: Elger
mesh_terms: D000161:Acoustic Stimulation / Q000379:methods; D000328:Adult; D001931:Brain Mapping; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008568:Memory / Q000502:physiology*; D008875:Middle Aged; D009483:Neuropsychological Tests; D010100:Oxygen / Q000097:blood; D010364:Pattern Recognition, Visual / Q000502:physiology; D010775:Photic Stimulation / Q000379:methods; D013702:Temporal Lobe / Q000098:blood supply / Q000502:physiology*; D014706:Verbal Learning / Q000502:physiology
chemical_list: D010100:Oxygen