title: Analysis of laterality and percentage of tumor involvement in 1386 prostatectomized specimens for selection of unilateral focal cryotherapy.
abstract: In total, 1386 paraffin embedded radical prostatectomy specimens from patients with clinically localized prostate cancer (PCa) excised between 2002-06 were analyzed. Pathologic assessment paid particular attention to laterality and percentage of tumor involvement (PTI) along with pathologic Gleason Score (pGS). Completely unilateral cancers were identified in 254 (18.3%) patients, and in 39% cases of them the signs of clinically significant PCa were revealed. The majority of unilateral tumors (72%) were low volume with a PTI of < or =5. This study suggests that only a select group of men diagnosed with PCa have completely unilateral cancers that would be amenable to focal ablation therapy targeting 1 lobe. Further study is needed to develop predictive models for those patients likely to have small, unilateral cancers that may be amenable to focal therapy.
authors: Division of Urology, Department of Surgery, Duke Prostate Center and Duke University Medical Center, Durham, NC, 27710 USA.
authors: Vladimir
authors: V
authors: Mouraviev
authors: Janice M
authors: JM
authors: Mayes
authors: John F
authors: JF
authors: Madden
authors: Leon
authors: L
authors: Sun
authors: Thomas J
authors: TJ
authors: Polascik
mesh_terms: D017679:Cryotherapy / Q000379:methods*; D006801:Humans; D008297:Male; D009367:Neoplasm Staging; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000473:pathology* / Q000601:surgery / Q000628:therapy*