title: Why are Dutch rheumatologists reluctant to use the COBRA treatment strategy in early rheumatoid arthritis?
abstract: BACKGROUND
  The Combinatietherapie Bij Reumatoide Artritis (COBRA) trial has proved that combination therapy with prednisolone, methotrexate and sulphasalazine is superior to sulphasalazine monotherapy in suppressing disease activity and radiological progression of early rheumatoid arthritis (RA). In addition, 5 years of follow-up proved that COBRA therapy results in sustained reduction of the rate of radiological progression. Despite this evidence, Dutch rheumatologists seem reluctant to prescribe COBRA therapy.
  
  
  OBJECTIVE
  To explore the reasons for the reluctance in Dutch rheumatologists to prescribe COBRA therapy.
  
  
  METHODS
  A short structured questionnaire based on social-psychological theories of behaviour was sent to all Dutch rheumatologists (n = 230).
  
  
  RESULTS
  The response rate was 50%. COBRA therapy was perceived as both effective and safe, but complex to administer. Furthermore, rheumatologists expressed their concern about the large number of pills that had to be taken, the side effects of high-dose prednisolone and the low dose of methotrexate. Although the average attitude towards the COBRA therapy was slightly positive (above the neutral point), the majority of responding rheumatologists had a negative intention (below the neutral point) to prescribe COBRA therapy in the near future.
  
  
  CONCLUSIONS
  The reluctance of Dutch rheumatologists to prescribe effective COBRA therapy may be due to perceptions of complexity of the treatment schedule and negative patient-related consequences of the therapy.
authors: Department of Clinical Epidemiology & Biostatistics, VU University Medical Center, PO Box 7057, 1053 MB Amsterdam, The Netherlands. L.vantuyl@vumc.nl
authors: Lilian H D
authors: LH
authors: van Tuyl
authors: Anne Marie C
authors: AM
authors: Plass
authors: Willem F
authors: WF
authors: Lems
authors: Alexandre E
authors: AE
authors: Voskuyl
authors: Ben A C
authors: BA
authors: Dijkmans
authors: Maarten
authors: M
authors: Boers
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D018501:Antirheumatic Agents / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D001291:Attitude of Health Personnel; D004359:Drug Therapy, Combination; D019538:Health Care Surveys; D006801:Humans; D008727:Methotrexate / Q000627:therapeutic use; D009426:Netherlands; D011239:Prednisolone / Q000627:therapeutic use; D016032:Randomized Controlled Trials as Topic; D012219:Rheumatology; D012460:Sulfasalazine / Q000627:therapeutic use; D011795:Surveys and Questionnaires
chemical_list: D000893:Anti-Inflammatory Agents; D018501:Antirheumatic Agents; D012460:Sulfasalazine; D011239:Prednisolone; D008727:Methotrexate