Pyrimidine transport activities in trypanosomes.
Parasites of the Trypanosomatidae family are unable to synthesize purines. Instead, they rely on their hosts to supply these necessary compounds. The article by Gudin et al. identifies three transport mechanisms of the equilibrative nucleoside transporter family by which nucleosides and nucleobases are transported in this medically important family of organisms. The work by Gudin et al. characterizes the dynamics of these transporters and points to further areas for future genetic and therapeutic experiments.
Bellofatto
Vivian
V
Department of Microbiology and Molecular Genetics, University of Medicine and Dentistry of New Jersey, Newark, NJ 07101, USA. bellofat@umdnj.edu
D000818:Animals; D001692:Biological Transport; D009154:Mutation; D033702:Nucleobase Transport Proteins / Q000235:genetics / Q000378:metabolism*; D033703:Nucleoside Transport Proteins / Q000235:genetics / Q000378:metabolism*; D015800:Protozoan Proteins / Q000235:genetics / Q000378:metabolism; D011687:Purines / Q000378:metabolism; D011743:Pyrimidines / Q000096:biosynthesis / Q000378:metabolism*; D014345:Trypanosoma / Q000235:genetics* / Q000378:metabolism*; D014346:Trypanosoma brucei brucei / Q000235:genetics / Q000378:metabolism
D033702:Nucleobase Transport Proteins; D033703:Nucleoside Transport Proteins; D015800:Protozoan Proteins; D011687:Purines; D011743:Pyrimidines; C030986:pyrimidine; C030985:purine