title: Early stage biliary and intrahepatic migration of Opisthorchis viverrini in the golden hamster.
abstract: In Thailand, infection with the liver fluke Opisthorchis viverrini is a serious health problem, with over 8.6 million human infections each year. Early stage biliary intrahepatic migration and infection of O. viverrini in the Syrian golden hamster were used to study the growth and development of this fluke. Fifty metacercariae of O. viverrini were introduced into each hamster by gastric intubation. Worms were found to migrate rapidly from the stomach to the gall bladder and hepatic duct, where they remained in relatively constant numbers until the end of week 8. Sexual development of worms was rapid, with full development of the uterus and testes by one and one half weeks and the appearance of eggs in the uterus by the beginning of the third week of infection. Worm growth as indicated by body length had ceased by week 8. Hamsters demonstrated development of a full reproductive cycle with in three to four weeks, and this generation continued until 8 weeks.
authors: Department of Biological Science, Faculty of Science and Technology, Huachiew Chalermprakiet University, Samut Prakan 10540, Thailand. choosak@hcu.ac.th
authors: C
authors: C
authors: Nithikathkul
authors: S
authors: S
authors: Tesana
authors: P
authors: P
authors: Sithithaworn
authors: S
authors: S
authors: Balakanich
mesh_terms: D000818:Animals; D006224:Cricetinae; D006790:Host-Parasite Interactions; D006801:Humans; D008109:Liver Diseases, Parasitic / Q000469:parasitology / Q000662:veterinary*; D008647:Mesocricetus / Q000469:parasitology*; D009889:Opisthorchiasis / Q000469:parasitology*; D009891:Opisthorchis / Q000254:growth & development / Q000302:isolation & purification* / Q000469:parasitology