[Two cases of Pseudomonas aeruginosa neonatal meningitis treated by ciprofloxacine].
Two cases of Pseudomonas aeruginosa neonatal meningitis are reported. Case 1 occurred on day 6 of life, at home, in a full term newborn. Favourable outcome was obtained with a treatment associating ceftazidime, 21 days, gentamicin, 10 days and ciprofloxacin, 10 days. Case no 2 was a nosocomial meningitis in a 32 weeks and 4 days gestational age premature newborn. Despite in vitro effective antibiotherapy with ceftazidime, netilmicine and ciprofloxacine, six cerebral abscesses were observed during the second week of treatment. Ceftazidime was stopped after 6 weeks and ciprofloxacine prolonged until neuroradiological cure of cerebral lesions at one year of age. Normal outcome was observed at 3 and 4 and half year of age. Therapeutic indications and clinical tolerance of ciprofloxacine in neonatal meningitis are discussed.
Tanase-Derkaoui
D
D
Service de néonatologie et de réanimation néonatale, hôpital Robert-Debré, 48, boulevard Serurier, 75010 Paris, France.
le Huidoux
P
P
Farnoux
C
C
El-Moussawi
F
F
Mariani-Kurkdjian
P
P
Bingen
E
E
Baud
O
O
Aujard
Y
Y
D000890:Anti-Infective Agents / Q000627:therapeutic use*; D002939:Ciprofloxacin / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D016920:Meningitis, Bacterial / Q000188:drug therapy*; D011552:Pseudomonas Infections / Q000188:drug therapy*
D000890:Anti-Infective Agents; D002939:Ciprofloxacin