Activity of 20S proteosomes and content of oxidized proteins in rat liver after long-term cold exposure.
We studied the effect of long-term (5 and 10 days) cold exposure (4 degrees C) on oxidative damage to proteins and proteosomal activity in the liver of Wistar rats. It was shown that core temperature on the 10th day of cold exposure decreased by 1.1 degrees C. The content of oxidized proteins increased at this term. Chymotrypsin-like and peptidylglutamyl peptide hydrolyzing activities increased, while trypsin-like activity decreased during cold exposure.
Perepechaeva
M L
ML
Laboratory of Biochemistry of Xenobiotics, Institute of Molecular Biology and Biophysics, Siberian Division of Russian Academy of Medical Sciences, Institute of Cytology and Genetics, Siberian Division of Russian Academy of Sciences, Novosibirsk.
Kolosova
N G
NG
Grishanova
A Yu
AY
D000222:Adaptation, Physiological / Q000502:physiology*; D000818:Animals; D003080:Cold Temperature; D005453:Fluorescence; D008099:Liver / Q000378:metabolism*; D008297:Male; D018384:Oxidative Stress / Q000502:physiology; D010447:Peptide Hydrolases / Q000378:metabolism; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D010447:Peptide Hydrolases; D046988:Proteasome Endopeptidase Complex