title: DNA damage, p53, apoptosis and vascular disease.
abstract: Atherosclerosis is the commonest cause of death in the Western world. The atherosclerotic plaque shows evidence of DNA damage, activation of damage repair pathways, p53 expression and apoptosis, involving a variety of different cell types. This review summarises the evidence for DNA damage in atherosclerosis, the likely stimuli inducing damage, and the increasing role of p53 in mediating apoptosis and its consequences in atherosclerosis.
authors: Division of Cardiovascular Medicine, University of Cambridge, P.O. Box 110, Addenbrooke's Hospital, Cambridge CB2 2QQ, United Kingdom.
authors: John
authors: J
authors: Mercer
authors: Melli
authors: M
authors: Mahmoudi
authors: Martin
authors: M
authors: Bennett
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000235:genetics; D050197:Atherosclerosis / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D004249:DNA Damage; D004730:Endothelium, Vascular / Q000378:metabolism / Q000473:pathology; D006801:Humans; D018384:Oxidative Stress / Q000235:genetics; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis* / Q000235:genetics; D014652:Vascular Diseases / Q000235:genetics / Q000378:metabolism / Q000473:pathology
chemical_list: D016159:Tumor Suppressor Protein p53