Systemic doxycycline and nonsurgical periodontal treatment in diabetic patients.
METHODS
This was a randomised controlled trial (RCT).


METHODS
Group 1 (30 patients) was given oral-hygiene instruction, scaling and root planing, chlorhexidine rinses twice a day and doxycycline (100 mg/day for 15 days). Group 2 (30 patients) had the same treatment but without doxycycline.


METHODS
Plaque index (PI), probing pocket depth (PPD), clinical attachment levels (CAL) and bleeding on probing (BOP) were recorded.


RESULTS
Both groups had a measurable improvement in all periodontal parameters, since PI, BOP, PPD and CAL were reduced. The reduction in PPD of 6 mm and in BOP became statistically significant when doxycycline was used (group 1), however.


CONCLUSIONS
Although both periodontal treatment regimens are effective in type-1 diabetics, the use of doxycycline as an adjunct provided more significant results when good plaque control was achieved.
Eickholz
Peter
P
Department of Periodontology, Centre for Dental, Oral and Maxillofacial Medicine (Carolinum), Hospital of the Johann Wolfgang Goethe-Universität Frankfurt am Main, Frankfurt/Main, Germany.