[Lipid peroxidation and antioxidant defense in patients with ischemic heart disease: correction with free-load bicycle exercise].
OBJECTIVE
To study changes in lipid peroxidation-antioxidant defense (LPO-AOD) system in patients with various clinical forms of ischemic heart disease (IHD) in response to free-load bicycle exercise (FBE).


METHODS
A total of 185 IHD patients aged 46-76 years (mean age 68.4 +/- 1.6 years, 99 males and 86 females) were randomized into two groups. Group 1 consisted of 90 patients who received standard medication and FBE. Group 2 of 95 patients received only standard medication. Thirty four healthy controls entered the control group. Each group was divided into subgroups by a clinical form of IHD. LPO was assessed by plasma levels of lipid peroxide (LP), malonic dialdehyde (MDA), AOD--by total antioxidant activity (TAA) in plasma red cells, activity of superoxide dismutase (SOD) and catalase in red cells.


RESULTS
Irrespective of a clinical form of IHD, conventional therapy stimulated AOD and decreased LP by 15.1% (p < 0.05), MDA by 21.4% (p < 0.05), on the average, but still these parameters were higher than in healthy controls. The addition of FBE reduced AOD to the levels of that of healthy controls, enhanced AOD the activation of which depended on a clinical form of IHD.


CONCLUSIONS
FBE elevates antiradical potential of blood in trained patients with different clinical forms of IHD. The highest effect was observed on enzymatic link of the AOD system.
Chursina
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Molchanov
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D000368:Aged; D000975:Antioxidants / Q000378:metabolism*; D001642:Bicycling / Q000502:physiology*; D015415:Biomarkers / Q000097:blood; D002374:Catalase / Q000097:blood; D004562:Electrocardiography; D004912:Erythrocytes / Q000201:enzymology; D005081:Exercise Therapy / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015227:Lipid Peroxidation; D008054:Lipid Peroxides / Q000097:blood; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood / Q000503:physiopathology / Q000628:therapy; D013482:Superoxide Dismutase / Q000097:blood; D016896:Treatment Outcome
D000975:Antioxidants; D015415:Biomarkers; D008054:Lipid Peroxides; D008315:Malondialdehyde; D002374:Catalase; D013482:Superoxide Dismutase