title: Personalised nutrition: status and perspectives.
abstract: Personalised, genotype-based nutrition is a concept that links genotyping with specific nutritional advice in order to improve the prevention of nutrition-associated, chronic diseases. This review describes the current scientific basis of the concept and discusses its problems. There is convincing evidence that variant genes may indeed determine the biological response to nutrients. The effects of single-gene variants on risk or risk factor levels of a complex disease are, however, usually small and sometimes inconsistent. Thus, information on the effects of combinations of relevant gene variants appears to be required in order to improve the predictive precision of the genetic information. Furthermore, very few associations between genotype and response have been tested for causality in human intervention studies, and little is known about potential adverse effects of a genotype-derived intervention. These issues need to be addressed before genotyping can become an acceptable method to guide nutritional recommendations.
authors: German Institute of Human Nutrition Potsdam-Rehbruecke, Arthur-Scheunert-Allee 114-116, Nuthetal, Germany. joost@mail.dife.de
authors: Hans-Georg
authors: HG
authors: Joost
authors: Michael J
authors: MJ
authors: Gibney
authors: Kevin D
authors: KD
authors: Cashman
authors: Ulf
authors: U
authors: Görman
authors: John E
authors: JE
authors: Hesketh
authors: Michael
authors: M
authors: Mueller
authors: Ben
authors: B
authors: van Ommen
authors: Christine M
authors: CM
authors: Williams
authors: John C
authors: JC
authors: Mathers
mesh_terms: D002908:Chronic Disease; D005502:Food; D005838:Genotype; D006801:Humans; D008957:Models, Genetic; D009748:Nutrition Disorders / Q000235:genetics; D009747:Nutritional Physiological Phenomena / Q000235:genetics*; D009751:Nutritional Requirements; D012106:Research / Q000639:trends