[Stress-hyperresponsive period in postnatal development of hypothalamic-hypophyseal-adrenal system in mice].
to compare response to stress, activity of adenylatcyclase and enzymes of steroidogenesis in adrenal cells in 3-week and adult (15-week) mice. In 3-week mice, basal and stressor level of blood corticosterone was increased. Their response to stress was faster developing as compared with adult mice. In vitro, 3-week mice had enhanced adrenal sensitivity to ACTH, corticosterone release in response to ACTH, exogenous cAMP and progesterone; and the cAMP level in the cells stimulated with ACTH and forscoline. Thus, in 3-week mice, a stress-hyperresponsive period occurs due to increased release of corticosterone and adrenal sensitivity to ACTH. The reason of this involves enhanced activity of adenylatcyclase and intracellular enzymes of steroidogenesis.
Shevchenko
Iu A
IuA
Institute of Cytology and Genetics of the SB RAS, 10 Pr. Lavrentieva, Novosibirsk, Russia.
Iakovleva
T V
TV
Makarova
E N
EN
Bazhan
N M
NM
D000324:Adrenocorticotropic Hormone / Q000378:metabolism / Q000494:pharmacology; D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism; D006728:Hormones / Q000378:metabolism / Q000494:pharmacology; D007030:Hypothalamo-Hypophyseal System / Q000254:growth & development* / Q000378:metabolism; D008297:Male; D051379:Mice; D010913:Pituitary-Adrenal System / Q000254:growth & development* / Q000378:metabolism; D011374:Progesterone / Q000378:metabolism; D013312:Stress, Physiological / Q000378:metabolism
D006728:Hormones; D011374:Progesterone; D000324:Adrenocorticotropic Hormone; D000242:Cyclic AMP