Neutrophilic dermatosis resembling pyoderma gangrenosum in a dog with polyarthritis.
This report describes a case of neutrophilic dermatosis in a dog, with a number of clinical and pathological similarities to human pyoderma gangrenosum. A seven-year-old, female German shepherd dog with a history of non-erosive idiopathic polyarthritis was presented with severe facial swelling, bilateral erosivoulcerative lesions on the muzzle and multiple, eroded, dermal-subcutaneous nodules on the cranial trunk. Histopathological examination of skin biopsies revealed a necrotising neutrophilic dermatitis. No infectious agents could be detected using specific stains, immunohistochemistry, serology and bacterial aerobic, anaerobic or fungal cultures. A sterile neutrophilic dermatosis resembling human pyoderma gangrenosum was presumptively diagnosed, and the patient showed an excellent response to treatment with prednisone and ciclosporin.
Bardagí
M
M
Department of Animal Medicine & Surgery and Veterinary Teaching Hospital, Veterinary School, Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain.
Lloret
A
A
Fondati
A
A
Ferrer
L
L
D000818:Animals; D001168:Arthritis / Q000150:complications / Q000662:veterinary; D016572:Cyclosporine / Q000627:therapeutic use; D003879:Dermatologic Agents / Q000627:therapeutic use*; D003937:Diagnosis, Differential; D004283:Dog Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D004285:Dogs; D005260:Female; D011241:Prednisone / Q000627:therapeutic use; D017511:Pyoderma Gangrenosum / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary; D016463:Sweet Syndrome / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D016896:Treatment Outcome
D003879:Dermatologic Agents; D016572:Cyclosporine; D011241:Prednisone