title: Synthesis of densely functionalised arenes using [2 + 2 + 2] cycloaddition reactions.
abstract: Rh(I)-catalysed [2 + 2 + 2] cycloaddition allows the synthesis of aryl ethers and diaryl methanes containing a high degree of steric hindrance from relatively simple diyne and alkyne precursors. The diarylmethanes made in this way show no evidence in their NMR spectra, however, of rotational restriction.
authors: School of Chemistry, The University of Manchester, Oxford Road, Manchester, UK. clayden@man.ac.uk
authors: Jonathan
authors: J
authors: Clayden
authors: Wesley J
authors: WJ
authors: Moran
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D001555:Benzene Derivatives / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003500:Cyclization; D004987:Ethers / Q000138:chemical synthesis* / Q000737:chemistry; D008697:Methane / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry; D012238:Rhodium / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000480:Alkynes; D001555:Benzene Derivatives; D004987:Ethers; D009942:Organometallic Compounds; D012238:Rhodium; D008697:Methane