Ribonucleoprotein remodeling during RNA localization.
Cytoplasmic RNA localization is a means to create polarity by restricting protein expression to a discrete subcellular location. RNA localization is a multistep process that begins with the recognition of cis-acting sequences within the RNA by specific trans-factors, and RNAs are localized in ribonucleoprotein (RNP) complexes that contain both the RNA and numerous protein components. Components of the localization machinery transport the RNP complex, usually in a translationally repressed state, to a distinct subcellular region, resulting in spatially restricted gene expression. Recent efforts to identify both the cis- and trans-factors required for RNA localization have elucidated RNA-protein interactions that are remodeled during localization.
Lewis
Raymond A
RA
Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02912, USA.
Mowry
Kimberly L
KL
D000818:Animals; D008954:Models, Biological; D009865:Oocytes / Q000378:metabolism; D012313:RNA / Q000378:metabolism*; D012323:RNA Processing, Post-Transcriptional; D034443:RNA Transport; D012261:Ribonucleoproteins / Q000378:metabolism*; D014981:Xenopus
D012261:Ribonucleoproteins; D012313:RNA