title: Modulation of chemokines by staphylococcal superantigen in atopic dermatitis.
abstract: Atopic dermatitis is a common pruritic and chronically relapsing inflammatory skin disease. Atopic dermatitis patients show disturbed skin barrier functions, frequent allergic responses against allergens, defects in the antimicrobial immune defense, and a genetic predisposition. Clinical and experimental evidence points to a role for staphylococcal superantigens during the initiation and amplification of atopic skin inflammation. In the past decade, numerous studies identified chemokines including CCL1, CCL2, CCL3, CCL4, CCL5, CCL11, CCL13, CCL17, CCL18, CCL20, CCL22, CCL26, CCL27 and CX3CL1 to be associated with atopic dermatitis. Here we summarize recent findings suggesting a role for staphylococcal superantigens in the production of chemokines during the development of atopic skin inflammation.
authors: Department of Dermatology, Heinrich-Heine University, Düsseldorf, Germany.
authors: Bernhard
authors: B
authors: Homey
authors: Stephan
authors: S
authors: Meller
authors: Terhi
authors: T
authors: Savinko
authors: Harri
authors: H
authors: Alenius
authors: Antti
authors: A
authors: Lauerma
mesh_terms: D000818:Animals; D018925:Chemokines / Q000096:biosynthesis*; D003876:Dermatitis, Atopic / Q000276:immunology*; D006801:Humans; D019707:Receptors, Chemokine / Q000032:analysis; D013210:Staphylococcus / Q000276:immunology*; D018089:Superantigens / Q000276:immunology*; D018417:Th1 Cells / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology
chemical_list: D018925:Chemokines; D019707:Receptors, Chemokine; D018089:Superantigens