title: Relationship of physical activity, fitness, and fatness with clustered metabolic risk in children and adolescents: the European youth heart study.
abstract: OBJECTIVE
  To examine the associations of physical activity (PA) at different levels and intensities and cardiorespiratory fitness (CRF) with a clustering of metabolic risk factors in children and adolescents with special consideration of body fat.
  
  
  METHODS
  Total PA and intensity levels were measured by accelerometry in children (9 years, n = 273) and adolescents (15 years, n = 256). CRF was measured with a maximal ergometer bike test. Measured outcomes included fasting insulin, glucose, triglycerides, total and high-density lipoprotein cholesterol, blood pressure, and body fat. A metabolic risk score (MRS) was computed as the mean of the standardized outcome scores. A "non-obesity-MRS" was computed omitting body fat from the MRS. Analysis of variance and multiple regressions were used in the analysis.
  
  
  RESULTS
  Total and vigorous PA was inversely significantly associated with MRS in adolescent girls, the group with lowest PA, becoming insignificant when CRF was introduced in the analysis. Significant regression coefficients of total PA and CRF on non-obesity-MRS diminished when body fat was entered in the analysis.
  
  
  CONCLUSIONS
  CRF is more strongly correlated to metabolic risk than total PA, whereas body fat appears to have a pivotal role in the association of CRF with metabolic risk.
authors: Unit for Preventive Nutrition, Department of Biosciences and Nutrition, NOVUM, Karolinska Institutet, Huddinge, Sweden.
authors: Nico S
authors: NS
authors: Rizzo
authors: Jonatan R
authors: JR
authors: Ruiz
authors: Anita
authors: A
authors: Hurtig-Wennlöf
authors: Francisco B
authors: FB
authors: Ortega
authors: Michael
authors: M
authors: Sjöström
mesh_terms: D050154:Adiposity; D000293:Adolescent; D017677:Age Distribution; D002648:Child; D015897:Comorbidity; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology*; D009043:Motor Activity; D009765:Obesity / Q000453:epidemiology; D010809:Physical Fitness; D012044:Regression Analysis; D012307:Risk Factors; D017678:Sex Distribution; D013548:Sweden / Q000453:epidemiology