Familial occurrence of painful subacute thyroiditis associated with human leukocyte antigen-B35.
BACKGROUND
Subacute thyroiditis (SAT) is a spontaneously remitting inflammatory disorder of the thyroid that is presumed to be virally induced in genetically predisposed individuals. A strong association has been suggested between human leukocyte antigen (HLA)-B35 and patients who developed SAT. However, familial occurrence of SAT associated with HLA-B35 is reported only rarely.


METHODS
We report three sibs, (two brothers and one sister) living in the same Lebanese town, who developed SAT during an 18-month-period. All tested positive for HLA-B35.


CONCLUSIONS
The family described here represents the first Third World third familial report of SAT associated with HLA-B35. It highlights the probably underestimated importance of genetic predisposition to SAT in families.
Zein
Emile F
EF
Internal medicine and infectious diseases department, Saint-Joseph Hospital and Medical Center, Dora, Lebanon. dremilezein2000@yahoo.com
Karaa
Souheil E
SE
Megarbane
André
A
D000284:Administration, Oral; D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage / Q000627:therapeutic use; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D020022:Genetic Predisposition to Disease; D015797:HLA-B35 Antigen / Q000235:genetics*; D006801:Humans; D007660:Ketoprofen / Q000008:administration & dosage / Q000627:therapeutic use; D008297:Male; D011241:Prednisone / Q000008:administration & dosage / Q000627:therapeutic use; D011433:Propranolol / Q000008:administration & dosage / Q000627:therapeutic use; D013968:Thyroiditis, Subacute / Q000175:diagnosis / Q000188:drug therapy* / Q000235:genetics* / Q000276:immunology; D013997:Time Factors; D016896:Treatment Outcome
D000319:Adrenergic beta-Antagonists; D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D015797:HLA-B35 Antigen; D007660:Ketoprofen; D011433:Propranolol; D011241:Prednisone