Syntheses of hemoprotein models that can be covalently attached onto electrode surfaces by click chemistry.
Five alkyne-containing hemoprotein models have been synthesized in a convergent manner. Sonogashira coupling was used to introduce the alkyne functional group on the proximal imidazole before or after being attached on the porphyrin. One model was immobilized onto a gold electrode surface via copper(I)-catalyzed azide-alkyne cycloaddition (Sharpless click chemistry).
Decréau
Richard A
RA
Department of Chemistry, Stanford University, Stanford, California 94305-5080, USA.
Collman
James P
JP
Yang
Ying
Y
Yan
Yilong
Y
Devaraj
Neal K
NK
D000480:Alkynes / Q000737:chemistry; D001386:Azides / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry; D004563:Electrochemistry; D004566:Electrodes; D006046:Gold / Q000737:chemistry; D006420:Hemeproteins / Q000737:chemistry* / Q000378:metabolism; D008954:Models, Biological; D015394:Molecular Structure; D013499:Surface Properties
D000480:Alkynes; D001386:Azides; D006420:Hemeproteins; D006046:Gold; D003300:Copper