title: Echinosporins as new cell cycle inhibitors and apoptosis inducers from marine-derived Streptomyces albogriseolus.
abstract: Bioassay-guided fractionation of the ethyl acetate extract from the fermentation broth of marine-derived Streptomyces albogriseolus A2002 led to the isolation of echinosporin (1) and 7-deoxyechinosporin (2). Compound 1 inhibited the proliferation of tsFT210, K562 and HCT-15 cancer cells (IC(50) 91.5 microM, 25.1 microM and 247 microM respectively) and 2 showed the same effect on K562 cells (IC(50) 143 microM). Flow cytometric analysis suggested that 1 and 2 exert their anti-proliferative effects on those cells through inhibiting cell cycle at the G(2)/M phase and inducing apoptosis.
authors: Key Laboratory of Marine Drugs, Chinese Ministry of Education, Institute of Marine Drugs and Foods, Ocean University of China, Qingdao 266003, PR China. cuicb@sohu.com
authors: C B
authors: CB
authors: Cui
authors: H B
authors: HB
authors: Liu
authors: J Y
authors: JY
authors: Gu
authors: Q Q
authors: QQ
authors: Gu
authors: B
authors: B
authors: Cai
authors: D Y
authors: DY
authors: Zhang
authors: T J
authors: TJ
authors: Zhu
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D017209:Apoptosis / Q000187:drug effects*; D002453:Cell Cycle / Q000187:drug effects*; D045744:Cell Line, Tumor / Q000187:drug effects; D020128:Inhibitory Concentration 50; D007783:Lactones / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D008517:Phytotherapy; D013302:Streptomyces
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D007783:Lactones; C034567:echinosporin