title: Comparative analysis of the Corynebacterium glutamicum group and complete genome sequence of strain R.
abstract: The complete genome sequence of Corynebacterium glutamicum strain R was determined to allow its comparative analysis with other corynebacteria. The biology of corynebacteria was explored by refining the definition of the subset of genes that constitutes the corynebacterial core as well as those characteristic of saprophytic and pathogenic ecological niches. In addition, the relative scarcity of corynebacterial sigma factors and the plasticity of their two-component system machinery reflect their relatively exacting nutritional requirements and reduced membrane-associated and secreted proteins. The conservation of key genes and pathways between corynebacteria, mycobacteria and Nocardia validates the use of C. glutamicum to study fundamental processes that are conserved in slow-growing mycobacteria, including pathogenesis-associated mechanisms. The discovery of 39 novel genes in C. glutamicum R that have not been previously reported in other corynebacteria supports the rationale for sequencing additional corynebacterial genomes to better define the corynebacterial pan-genome and identify previously undetected metabolic pathways in these organisms.
authors: Graduate School of Biological Sciences, Nara Institute of Science and Technology, Ikoma, Nara 630-0101, Japan.|Microbiology Research Group, Research Institute of Innovative Technology for the Earth (RITE), Soraku, Kyoto 619-0292, Japan.
authors: Hideaki
authors: H
authors: Yukawa
authors: Microbiology Research Group, Research Institute of Innovative Technology for the Earth (RITE), Soraku, Kyoto 619-0292, Japan.
authors: Crispinus A
authors: CA
authors: Omumasaba
authors: Microbiology Research Group, Research Institute of Innovative Technology for the Earth (RITE), Soraku, Kyoto 619-0292, Japan.
authors: Hiroshi
authors: H
authors: Nonaka
authors: Microbiology Research Group, Research Institute of Innovative Technology for the Earth (RITE), Soraku, Kyoto 619-0292, Japan.
authors: Péter
authors: P
authors: Kós
authors: Microbiology Research Group, Research Institute of Innovative Technology for the Earth (RITE), Soraku, Kyoto 619-0292, Japan.
authors: Naoko
authors: N
authors: Okai
authors: Microbiology Research Group, Research Institute of Innovative Technology for the Earth (RITE), Soraku, Kyoto 619-0292, Japan.
authors: Nobuaki
authors: N
authors: Suzuki
authors: Microbiology Research Group, Research Institute of Innovative Technology for the Earth (RITE), Soraku, Kyoto 619-0292, Japan.
authors: Masako
authors: M
authors: Suda
authors: Graduate School of Biological Sciences, Nara Institute of Science and Technology, Ikoma, Nara 630-0101, Japan.|Microbiology Research Group, Research Institute of Innovative Technology for the Earth (RITE), Soraku, Kyoto 619-0292, Japan.
authors: Yota
authors: Y
authors: Tsuge
authors: Microbiology Research Group, Research Institute of Innovative Technology for the Earth (RITE), Soraku, Kyoto 619-0292, Japan.
authors: Junko
authors: J
authors: Watanabe
authors: Microbiology Research Group, Research Institute of Innovative Technology for the Earth (RITE), Soraku, Kyoto 619-0292, Japan.
authors: Yoko
authors: Y
authors: Ikeda
authors: Microbiology Research Group, Research Institute of Innovative Technology for the Earth (RITE), Soraku, Kyoto 619-0292, Japan.
authors: Alain A
authors: AA
authors: Vertès
authors: Microbiology Research Group, Research Institute of Innovative Technology for the Earth (RITE), Soraku, Kyoto 619-0292, Japan.
authors: Masayuki
authors: M
authors: Inui
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D050260:Carbohydrate Metabolism; D048230:Corynebacterium glutamicum / Q000235:genetics* / Q000378:metabolism; D016680:Genome, Bacterial; D023281:Genomics; D008969:Molecular Sequence Data; D012808:Sigma Factor / Q000235:genetics; D013045:Species Specificity
chemical_list: D001426:Bacterial Proteins; D012808:Sigma Factor