title: Similar biochemical signatures and prion protein genotypes in atypical scrapie and Nor98 cases, France and Norway.
abstract: Isolates of atypical scrapie recently identified in sheep and goats in France were compared with Nor98 isolates reported in Norway. Western blot methods for characterization of the protease-resistant prion protein showed that all these isolates shared a unique biochemical signature: 5 groups of bands, including a characteristic band of apparent low molecular weight (11 kDa). This pattern could originate from the presence of 3 different protease cleavage products, including the 11 kDa most likely cleaved at both N- and C-sides of the protein. Genetic data, which strongly suggested the higher susceptibility of AHQ and AF141RQ animals in French cases, resembled earlier data from Nor98 scrapie.
authors: Agence Française de Sécurité Sanitaire des Aliments, Lyon, France.
authors: Jean-Noël
authors: JN
authors: Arsac
authors: Olivier
authors: O
authors: Andreoletti
authors: Jean-Marc
authors: JM
authors: Bilheude
authors: Caroline
authors: C
authors: Lacroux
authors: Sylvie L
authors: SL
authors: Benestad
authors: Thierry
authors: T
authors: Baron
mesh_terms: D000483:Alleles; D000818:Animals; D001933:Brain Stem / Q000378:metabolism; D005602:France / Q000453:epidemiology; D005838:Genotype; D015511:Goat Diseases / Q000453:epidemiology; D006041:Goats / Q000378:metabolism; D009664:Norway / Q000453:epidemiology; D011110:Polymorphism, Genetic; D011328:Prions / Q000235:genetics* / Q000302:isolation & purification*; D012608:Scrapie / Q000453:epidemiology* / Q000378:metabolism; D012756:Sheep / Q000378:metabolism
chemical_list: D011328:Prions