Brothers in arms? Common and contrasting themes in pathogen perception by plant NB-LRR and animal NACHT-LRR proteins.
Both plant and animal genomes encode proteins with nucleotide binding domains fused to leucine-rich repeat domains that are involved in responses to pathogens. While these domain structures are probably an example of convergent evolution, there are a number of similarities in the core mechanisms by which these proteins are regulated.
Rairdan
Greg
G
Boyce Thompson Institute for Plant Research, Ithaca, NY 14853, USA.
Moffett
Peter
P
D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D007113:Immunity, Innate / Q000276:immunology; D010940:Plant Proteins / Q000737:chemistry / Q000235:genetics / Q000276:immunology*; D012097:Repressor Proteins / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology
D048868:Adaptor Proteins, Signal Transducing; C466775:NLRP4 protein, human; D010940:Plant Proteins; D012097:Repressor Proteins