Lipid composition of rat somatic nerves under the effect of damaging factors.
Ligation of the sciatic nerve in rats led to reversible decrease in excitability and changes in lipid composition of myelinated nerve fiber: increase in the content of lysophosphatidylcholine, lysophosphatidylethanolamine, and free fatty acids and phospholipase A2 activity. Xymedon and laminin accelerate nerve regeneration and restore its lipid composition.
Revin
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VV
N. P. Ogarev Mordovian State University; M. V. Lomonosov Moscow State University.
Yudanov
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MA
Maksimov
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GV
D000200:Action Potentials / Q000502:physiology; D000818:Animals; D002849:Chromatography, Gas; D005230:Fatty Acids, Nonesterified / Q000378:metabolism*; D007797:Laminin / Q000494:pharmacology; D008026:Ligation; D008244:Lysophosphatidylcholines / Q000378:metabolism*; D008246:Lysophospholipids / Q000378:metabolism*; D009416:Nerve Regeneration / Q000187:drug effects*; D010741:Phospholipases A / Q000378:metabolism*; D054467:Phospholipases A2; D011743:Pyrimidines / Q000494:pharmacology; D051381:Rats; D012584:Sciatic Nerve / Q000378:metabolism*
D005230:Fatty Acids, Nonesterified; D007797:Laminin; D008244:Lysophosphatidylcholines; D008246:Lysophospholipids; D011743:Pyrimidines; C008301:lysophosphatidylethanolamine; C069705:xymedon; D010741:Phospholipases A; D054467:Phospholipases A2