Relationship between serum levels of some acute-phase proteins and stage of disease and performance status in patients with lung cancer.
BACKGROUND
Lung cancer is the leading cause of cancer death in both developed and developing countries. The aim of the present study was to compare serum levels of alpha1-acid glycoprotein, ceruloplasmin, transferrin, ferritin, and albumin with tumor stage, distant metastasis, lymphadenopa thy, and patient performance status in patients with non-small-cell lung cancer and those with small-cell lung cancer.


METHODS
The study was carried out in 46 patients with primary lung cancer (39 men and 7 women) and 34 healthy subjects as the control group.


RESULTS
Serum ceruloplasmin and ferritin levels were higher and transferrin and albumin levels were lower both in non-small-cell and small-cell lung cancer patients than in controls. The levels of alpha1-acid glycoprotein and ferritin associated with both performance status and lymph node metastasis.


CONCLUSIONS
Measurement of alpha1-acid glycoprotein and ferritin levels could be a useful prognostic factor in addition to performance status in patient with primary lung cancer.
Yildirim
Abdulkadir
A
Department of Biochemistry, School of Medicine, Ataturk University, Erzurum, Turkey. kadir@atauni.edu.tr
Meral
Mehmet
M
Kaynar
Hasan
H
Polat
Harun
H
Ucar
Elif Yilmazel
EY
D000209:Acute-Phase Proteins / Q000032:analysis*; D000328:Adult; D000368:Aged; D002570:Ceruloplasmin / Q000032:analysis; D005260:Female; D005293:Ferritins / Q000097:blood; D006801:Humans; D008175:Lung Neoplasms / Q000097:blood* / Q000150:complications; D008206:Lymphatic Diseases / Q000097:blood / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009961:Orosomucoid / Q000032:analysis; D012709:Serum Albumin / Q000032:analysis; D018709:Statistics, Nonparametric; D014168:Transferrin / Q000032:analysis
D000209:Acute-Phase Proteins; D009961:Orosomucoid; D012709:Serum Albumin; D014168:Transferrin; D005293:Ferritins; D002570:Ceruloplasmin