title: Lipophilic substances in intraocular silicone oil.
abstract: OBJECTIVE
  To examine intravitreal silicone oil samples for lipophilic substances, including cholesterol, fatty acids, and derived methyl esters.
  
  
  METHODS
  Clinical interventional case series study.
  
  
  METHODS
  The study included 53 patients (53 eyes; mean age 57.6 years) who underwent removal of intravitreal silicone oil used for intraocular tamponade with pars plana vitrectomy for retinal detachment. The silicone oil was removed 8.3 +/- 5.7 months after pars plana vitrectomy and analyzed using gas chromatography with a flame ionization detector.
  
  
  RESULTS
  Cholesterol was present in all samples with a mean concentration of 65 +/- 32.3 microg/ml (95% confidence interval: 56.1 to 73.9 microg/ml). The concentration increased (P < .001) with the time of tamponade, and decreased (P = .003) with the age of the patients. Fatty acids along with derived methyl acids were detected in low concentrations in 49 samples (92.5%).
  
  
  CONCLUSIONS
  Cholesterol and lipophilic acids accumulate in intravitreal silicone oil used in intraocular tamponade.
authors: Institute of Applied Ophthalmobiology, University of Valladolid, Valladolid, Spain. pastor@ioba.med.uva.es <pastor@ioba.med.uva.es>
authors: José Carlos
authors: JC
authors: Pastor Jimeno
authors: Enrique Rodríguez
authors: ER
authors: de la Rúa
authors: Itziar
authors: I
authors: Fernández Martínez
authors: M Jesús
authors: MJ
authors: del Nozal Nalda
authors: Jost B
authors: JB
authors: Jonas
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D002784:Cholesterol / Q000032:analysis*; D002849:Chromatography, Gas; D004322:Drainage; D004952:Esters / Q000032:analysis; D005227:Fatty Acids / Q000032:analysis*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012163:Retinal Detachment / Q000188:drug therapy / Q000601:surgery*; D012827:Silicone Oils / Q000737:chemistry*; D013997:Time Factors; D014821:Vitrectomy; D014822:Vitreous Body / Q000737:chemistry
chemical_list: D004952:Esters; D005227:Fatty Acids; D012827:Silicone Oils; D002784:Cholesterol