Participation of mesenchymal precursor cells in wound healing on skin flap model.
We studied the state of different pools of mesenchymal precursor cells in the bone marrow, peripheral blood, and wound surface after modeling of tissue damage by skin flap removal. The participation of regional and circulating stromal precursors in the healing of skin defect and the absence of compensatory reaction of the regeneratory process deep reserve, mesenchymal stem cells of the bone marrow, was demonstrated.
Goldberg
E D
ED
Institute of Pharmacology, Tomsk Research Center, Siberian Division of Russian Academy of Medical Sciences.
Dygai
A M
AM
Zhdanov
V V
VV
Zyuz'kov
G N
GN
Gur'yantseva
L A
LA
Pershina
O V
OV
Povet'eva
T N
TN
Stavrova
L A
LA
Khrichkova
T Yu
TY
D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology / Q000502:physiology*; D002478:Cells, Cultured; D003114:Colony-Forming Units Assay; D005260:Female; D007328:Insulin; D036341:Intercellular Signaling Peptides and Proteins; D008297:Male; D059630:Mesenchymal Stem Cells / Q000502:physiology*; D051379:Mice; D008808:Mice, Inbred CBA; D012867:Skin / Q000293:injuries*; D018709:Statistics, Nonparametric; D017154:Stromal Cells / Q000166:cytology / Q000502:physiology; D014945:Wound Healing / Q000502:physiology*
D007328:Insulin; D036341:Intercellular Signaling Peptides and Proteins