Expression of matrix metalloproteinase 9 in pancreatic ductal carcinoma is associated with tumor metastasis formation.
The objective of the current study was to assess the expression of matrix metalloproteinase 9 (MMP-9) in pancreatic ductal carcinoma and to examine its correlation with chosen clinico-anatomical parameters. The study group consisted of 36 patients with pancreatic ductal carcinoma. Tumors were stained using immunohistochemical method (NCL -MMP-9, Novocastra). No correlation was found between tumor MMP-9 expression and age, gender or grade of histological malignancy. However, statistical analysis revealed a relationship between tumor MMP-9 expression and histological type (adenocarcinoma mucinosum) of pancreatic carcinoma. The expression was strongly correlated with lymph node involvement and occurrence of distant metastases (p<0.00001). The results indicate a correlation between the expression of MMP-9 in pancreatic ductal carcinoma and worse prognosis (shown by lymph node involvement and distant metastases).
Pryczynicz
Anna
A
Department of General Pathomorphology, Medical University of Białystok, Białystok, Poland.
Guzińska-Ustymowicz
Katarzyna
K
Dymicka-Piekarska
Violetta
V
Czyzewska
Jolanta
J
Kemona
Andrzej
A
D000328:Adult; D000367:Age Factors; D000368:Aged; D021441:Carcinoma, Pancreatic Ductal / Q000201:enzymology / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008198:Lymph Nodes / Q000378:metabolism; D008207:Lymphatic Metastasis; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism*; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000201:enzymology / Q000473:pathology*; D011379:Prognosis
D020780:Matrix Metalloproteinase 9