title: Risk factors for ovarian cancer histotypes.
abstract: To analyse the risk factors for different histologic types of ovarian cancer, we conducted a case-control study. The cases included 750 women with incident, histologically confirmed invasive epithelial ovarian cancer subdivided into: 493 serous, 81 mucinous, 78 endometrioid, and 98 other histologies. The controls included 2411 women admitted to the same hospitals as cases. The odds ratios for women with three or more births, in comparison with nulliparae, were 0.6 for serous, 0.4 for endometrioid, 1.0 for mucinous and 0.7 for other histological types of ovarian cancer. Family history of ovarian/breast cancer was associated to the risk of all ovarian cancer types, except mucinous ones. Selected dietary factors were less strongly directly (meat and starch), or inversely (fish and vitamin E) related to mucinous than to other histological types of ovarian cancer. High occupational physical activity was inversely related to the risk of ovarian cancer, with no heterogeneity across histologies. In conclusion, the association of reproductive factors and of selected dietary habits was weaker for mucinous ovarian cancer than for other histologic types.
authors: Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea, 62, Milan, Italy.
authors: Francesca
authors: F
authors: Chiaffarino
authors: Fabio
authors: F
authors: Parazzini
authors: Cristina
authors: C
authors: Bosetti
authors: Silvia
authors: S
authors: Franceschi
authors: Renato
authors: R
authors: Talamini
authors: Vincenzo
authors: V
authors: Canzonieri
authors: Maurizio
authors: M
authors: Montella
authors: Valerio
authors: V
authors: Ramazzotti
authors: Silvia
authors: S
authors: Franceschi
authors: Carlo
authors: C
authors: La Vecchia
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000453:epidemiology / Q000473:pathology*; D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D016022:Case-Control Studies; D004032:Diet / Q000009:adverse effects; D004522:Educational Status; D016889:Endometrial Neoplasms / Q000453:epidemiology / Q000473:pathology*; D005260:Female; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008875:Middle Aged; D009784:Occupational Diseases / Q000453:epidemiology; D016017:Odds Ratio; D010051:Ovarian Neoplasms / Q000453:epidemiology / Q000473:pathology*; D010375:Pedigree; D012307:Risk Factors