title: Assessment of left ventricular diastolic function and the Tei index by tissue Doppler imaging in patients with primary hyperparathyroidism.
abstract: BACKGROUND
  The aim of this study was to assess left ventricular (LV) systolic and diastolic function and myocardial performance (the Tei index) by tissue Doppler imaging (TDI) in patients with primary hyperparathyroidism (PHPT).
  
  
  METHODS
  We prospectively evaluated 21 patients with PHPT [nine women, 12 men; aged 50 +/- 11 years, serum calcium 2.9 +/- 0.17 mmol/l, intact PTH (iPTH) 51.5 +/- 52.1 pmol/l] and 27 healthy control subjects (13 women, 14 men; aged 49 +/- 10 years, serum calcium 2.35 +/- 0.12 mol/l, iPTH 2.9 +/- 0.9 pmol/l). LV systolic and diastolic function was assessed by conventional echocardiography and by TDI. Early diastolic (Em), late diastolic (Am) and peak systolic (Sm) mitral annular velocities, the ratio Em/Am and the Tei index were calculated from TDI measurements. Mitral inflow velocities, colour M-mode flow propagation velocity (Vp), relative wall thickness (RWT) and LV mass index (LVMI) were assessed by two-dimensional echocardiography.
  
  
  RESULTS
  Em and Em/Am were lower in patients with PHPT than in healthy controls (11.2 +/- 1.5 cm/s vs. 13.5 +/- 2.5 cm/s, P = 0.005; 0.94 +/- 0.27 vs. 1.36 +/- 0.44, P = 0.02, respectively). In patients with PHPT, the Tei index was significantly higher than that in controls (0.45 +/- 13.6 vs. 0.33 +/- 8.1, P = 0.02). Peak (E) velocity and the ratio of E to peak late (A) velocity (E/A) were lower in those with PHPT than in those without (59 +/- 15 cm/s vs. 72 +/- 19 cm/s, P = 0.02; 0.8 +/- 0.15 vs. 1.1 +/- 0.33, P = 0.001, respectively). Patients with PHPT had significantly higher RWT (0.50 +/- 0.02 cm vs. 0.41 +/- 0.02 cm, P = 0.0001), isovolumetric relaxation time (IVRT) (115 +/- 13 ms vs. 103 +/- 11 ms P = 0.04) and A velocity (79 +/- 16 cm/s vs. 68 +/- 13 cm/s P = 0.05) than controls. Vp was lower in PHPT patients than in healthy subjects (42 +/- 9.98 cm/s vs. 54 +/- 19.01 cm/s P = 0.04). There were no significant differences between the two groups regarding LV end-diastolic and end-systolic dimensions, LVMI, deceleration time of the mitral E wave, Am and Sm.
  
  
  CONCLUSIONS
  TDI analysis of mitral annular velocities, Em/Am and the Tei index is useful for assessing LV diastolic dysfunction in patients with PHPT. The parameters obtained from the lateral mitral annulus by TDI can be used for the identification of LV diastolic dysfunction in PHPT patients.
authors: Department of Cardiology, Division of Endocrinology and Metabolism, KTU Faculty of Medicine, Trabzon, Turkey. merihbaykan@yahoo.com
authors: Merih
authors: M
authors: Baykan
authors: Cihangir
authors: C
authors: Erem
authors: Turan
authors: T
authors: Erdogan
authors: Halil Onder
authors: HO
authors: Ersöz
authors: Omer
authors: O
authors: Gedikli
authors: Levent
authors: L
authors: Korkmaz
authors: Mehmet
authors: M
authors: Kücükosmanoglu
authors: Arif
authors: A
authors: Haclhasanoglu
authors: Sahin
authors: S
authors: Kaplan
authors: Sükrü
authors: S
authors: Celik
mesh_terms: D000328:Adult; D016009:Chi-Square Distribution; D003971:Diastole; D015150:Echocardiography, Doppler; D018618:Echocardiography, Doppler, Color; D018619:Echocardiography, Doppler, Pulsed; D005260:Female; D006321:Heart / Q000503:physiopathology*; D006801:Humans; D049950:Hyperparathyroidism, Primary / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction; D012680:Sensitivity and Specificity; D013318:Stroke Volume; D018487:Ventricular Dysfunction, Left / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology*