Lack of association between genetic variants in the mannose-binding lectin 2 (MBL2) gene and HPV infection.
Genetic variants in the immunomodulatory gene mannose-binding lectin 2 (MBL2), were associated with risk, severity, and frequency of viral infections. In a case-control setting, we investigated the association of MBL2 functional polymorphisms with Human Papillomas Virus (HPV) infection. No differences between cases (HPV(+)) and controls (HPV(-)) were found in the distribution of each single genotypes or allele. Haplotype analysis did not show any difference between HPV+ and HPV(-) groups.
Parrella
Paola
P
Laboratory of Oncology, Department of Research, IRCCS Casa Sollievo della Sofferenza, Viale Padre Pio, San Giovanni Rotondo, FG, I-71013, Italy. pparrella@operapadrepio.it
Seripa
Davide
D
Matera
Maria G
MG
Rinaldi
Monica
M
Signori
Emanuela
E
Gravina
Carolina
C
Gallo
Antonietta P
AP
Prencipe
Maria
M
Grandone
Elvira
E
Mariani
Luciano
L
Cordiali
Paola
P
Di Carlo
Aldo
A
Stentella
Patrizia
P
Pachì
Antonio
A
Fazio
Vito M
VM
D000328:Adult; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D037601:Mannose-Binding Lectin / Q000235:genetics*; D030361:Papillomavirus Infections / Q000453:epidemiology* / Q000235:genetics*; D011110:Polymorphism, Genetic
C445619:MBL2 protein, human; D037601:Mannose-Binding Lectin