Scedosporium prolificans brain abscess in a patient with chronic granulomatous disease: successful combination therapy with voriconazole and terbinafine.
A patient with chronic granulomatous disease developed brain abscesses with Scedosporium prolificans. In vitro susceptibility revealed a synergistic effect of terbinafine and voriconazole. He received therapy with both these antifungals which resulted in disappearance of the brain abscesses. This is the first reported cure of a CNS S. prolificans infection in an immunocompromised host.
Bhat
Sunil V
SV
Division of Infectious Diseases, The University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania. bhatsv@upmc.edu
Paterson
David L
DL
Rinaldi
Michael G
MG
Veldkamp
Peter J
PJ
D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use*; D001922:Brain Abscess / Q000188:drug therapy* / Q000382:microbiology; D020314:Central Nervous System Fungal Infections / Q000188:drug therapy*; D025141:Drug Resistance, Fungal / Q000187:drug effects; D006105:Granulomatous Disease, Chronic / Q000150:complications / Q000382:microbiology; D006801:Humans; D008297:Male; D009281:Naphthalenes / Q000627:therapeutic use*; D011743:Pyrimidines / Q000627:therapeutic use*; D021681:Scedosporium / Q000187:drug effects* / Q000472:pathogenicity; D000077291:Terbinafine; D014230:Triazoles / Q000627:therapeutic use*; D065819:Voriconazole
D000935:Antifungal Agents; D009281:Naphthalenes; D011743:Pyrimidines; D014230:Triazoles; D000077291:Terbinafine; D065819:Voriconazole