title: The TB pandemic: an old problem seeking new solutions.
abstract: Tuberculosis (TB) continues to kill more than 2 million people globally each year. Annual TB case notification rates have risen up to fourfold since the mid-1980s, with the highest rate of 1000/100,000 around Cape Town, South Africa. There is an urgent need for novel diagnostic methods and preventive vaccines to control this epidemic. The rising incidence of TB has been attributed to HIV co-infection especially in developing countries. The threat of drug resistance arising from ineffective TB treatment programmes is looming and could potentially lead to loss of any gains made in controlling the disease globally.
authors: Infectious Disease Institute, Makerere University, Kampala, Uganda. david.meya@gmail.com
authors: D B
authors: DB
authors: Meya
authors: K P W J
authors: KP
authors: McAdam
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy* / Q000635:transmission; D000995:Antitubercular Agents / Q000627:therapeutic use; D004196:Disease Outbreaks; D014943:Global Health; D006801:Humans; D012307:Risk Factors; D032581:Tuberculosis Vaccines / Q000627:therapeutic use; D018088:Tuberculosis, Multidrug-Resistant / Q000188:drug therapy; D014397:Tuberculosis, Pulmonary / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy* / Q000635:transmission
chemical_list: D000995:Antitubercular Agents; D032581:Tuberculosis Vaccines