title: Intra-fraction dose delivery timing during stereotactic radiotherapy can influence the radiobiological effect.
abstract: The sequence of incremental dose delivery during a radiotherapy fraction can potentially influence the radiobiological effect. This would be most noticeable during the long fractions characteristic of hypo-fractionated stereotactic radiotherapy and radiosurgery. We demonstrate here the spatio-temporal variation of dose delivery by the CyberKnife to a lung tumor and propose strategies to reduce and/or correct for any resultant dose-time cytotoxic effects.
authors: Department of Radiation Oncology, Virginia Commonwealth University, Richmond, Virginia 23298, USA. mjmurphy@vcu.edu
authors: Martin J
authors: MJ
authors: Murphy
authors: Peck-Sun
authors: PS
authors: Lin
authors: Cihat
authors: C
authors: Ozhasoglu
mesh_terms: D000465:Algorithms; D003198:Computer Simulation; D019583:Dose Fractionation, Radiation; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D008175:Lung Neoplasms / Q000601:surgery*; D008954:Models, Biological; D011853:Radiobiology / Q000379:methods; D011874:Radiometry / Q000379:methods*; D016634:Radiosurgery / Q000379:methods*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D012062:Relative Biological Effectiveness; D013997:Time Factors