title: Effect of pentobarbital on pH and electrolyte levels after induced seizure in rats.
abstract: We studied the effects of high doses of pentobarbital (PB) and carbamazepine (CBZ) on electrolyte levels and pH in an epileptic animal model. Pentobarbital decreased Ca2+ and Na+ levels without pentylenetetrazole (PTZ). After this, Ca2+ and Na+ levels continued to decrease except when CBZ was used, which preserved the Ca2+ levels PTZ may have opposed effects on PB. Our results suggest that PB causes changes in electrolyte levels and pH, but these changes are diminished by CBZ.
authors: Laboratory of Neurochemistry, National Institute of Rehabilitation, SSA, México City, Mexico.
authors: R
authors: R
authors: Uribe-Escamilla
authors: D
authors: D
authors: Mota-Rojas
authors: P
authors: P
authors: Sánchez-Aparicio
authors: M
authors: M
authors: Alonso-Spilsbury
authors: R
authors: R
authors: González-Piña
authors: A
authors: A
authors: Alfaro-Rodríguez
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology / Q000627:therapeutic use; D002118:Calcium / Q000378:metabolism; D002220:Carbamazepine / Q000494:pharmacology / Q000627:therapeutic use; D004195:Disease Models, Animal; D004347:Drug Interactions; D004573:Electrolytes / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration / Q000187:drug effects*; D006993:Hypnotics and Sedatives / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D010424:Pentobarbital / Q000494:pharmacology* / Q000627:therapeutic use; D010433:Pentylenetetrazole; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy / Q000378:metabolism*; D012964:Sodium / Q000378:metabolism; D018709:Statistics, Nonparametric
chemical_list: D000927:Anticonvulsants; D004573:Electrolytes; D006993:Hypnotics and Sedatives; D002220:Carbamazepine; D012964:Sodium; D010424:Pentobarbital; D002118:Calcium; D010433:Pentylenetetrazole