[Comparative study on effects of static pressure stimulation on release of PGE2 and IL-6 in fibroblasts in the rat "Zusanli" and its adjacent areas].
OBJECTIVE
To provide some possible theoretical and experimental basis for the modern biomedical mechanism of "receiving stimulation, preventing and treating diseases", by exploring the effects of pressure signal's biological transformation of rat "Zusanli" (ST 36) fascia tissue fibroblasts under mechanical stimulation.


METHODS
Pressure was given on rat "Zusanli" (ST 36) and its adjacent area's fascia tissue cells cultured in vitro and identified by morphology. The contents of prostaglandin E2 (PGE2) and interleukin-6 (IL-6) in culture medium were detected.


RESULTS
The fascia tissue cells in "Zusanli" and its adjacent area are almost consisted of fibroblasts. The pressure stimulation significantly accelerated the synthesis and release of PGE2 and IL-6.


CONCLUSIONS
Acupoint and non-acupoint fibroblasts can directly receive mechanical stimulation, and then the mechanical signals were transformed as biological ones.
Chen
Bo
B
Guiyang College of TCM, Guizhou 550002, China. chenbomed@yahoo.com.cn
Luo
Yong-Fen
YF
Cui
Jin
J
Feng
Ling-Mei
LM
Yang
Xiao-Fang
XF
Feng
Lin
L
D019050:Acupressure; D015669:Acupuncture Points; D000818:Animals; D015232:Dinoprostone / Q000378:metabolism*; D005205:Fascia / Q000166:cytology*; D005347:Fibroblasts / Q000378:metabolism*; D015850:Interleukin-6 / Q000378:metabolism*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D015398:Signal Transduction / Q000502:physiology*
D015850:Interleukin-6; D015232:Dinoprostone