Antihypoxic, cardioprotective, and antifibrillation effects of a combined adaptogenic plant preparation.
The course of treatment with combined adaptogenic plant preparation Tonizid improved mouse survival under conditions of hypobaric hypoxia and reduced the necrotic zone/risk zone ratio during ischemia and reperfusion in rats under conditions of artificial ventilation. The test preparation decreased the size of the necrotic zone, but had no effect on the size of the risk zone. Tonizid prevented ventricular fibrillation during coronary occlusion and exhibited antihypoxic, cardioprotective, and antifibrillation properties.
Arbuzov
A G
AG
Biolit Company, Tomsk; Institute of Cardiology, Tomsk Research Center, Russian Academy of Medical Sciences.
Krylatov
A V
AV
Maslov
L N
LN
Burkova
V N
VN
Naryzhnaya
N V
NV
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002316:Cardiotonic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D000860:Hypoxia / Q000188:drug therapy*; D008297:Male; D051379:Mice; D009206:Myocardium / Q000473:pathology*; D009336:Necrosis / Q000188:drug therapy; D008517:Phytotherapy / Q000379:methods*; D028321:Plant Preparations / Q000494:pharmacology / Q000627:therapeutic use*; D015427:Reperfusion Injury / Q000188:drug therapy*; D029771:Rhodiola / Q000737:chemistry*
D000889:Anti-Arrhythmia Agents; D002316:Cardiotonic Agents; D028321:Plant Preparations