A non-alcoholic patient with acute Marchiafava-Bignami disease associated with gynecologic malignancy: paraneoplastic Marchiafava-Bignami disease?
We report a 45-year-old, non-alcoholic woman with ovarian cancer who presented with acute impairment of consciousness. Cranial MRI revealed symmetrical and bilateral increased signal intensities of the corpus callosum and the dentate nucleus, without contrast enhancement. The findings are comparable with Marchiafava-Bignami disease (MBD), although pathological confirmation was not possible. Most of the reported cases of MBD are related to chronic ingestion of red wine and/or related with a nutritional cause. We suggest that this patient may suffer a MBD possible related to the ovarian cancer.
Celik
Yahya
Y
Trakya University School of Medicine, Department of Neurology, Edirne, Turkey. celikyahyatr@yahoo.com <celikyahyatr@yahoo.com>
Temizoz
Osman
O
Genchellac
Hakan
H
Cakir
Bilge
B
Asil
Talip
T
D000428:Alcohol Drinking / Q000009:adverse effects; D001927:Brain Diseases / Q000175:diagnosis*; D002529:Cerebellar Nuclei / Q000473:pathology; D003244:Consciousness Disorders / Q000175:diagnosis; D003337:Corpus Callosum / Q000473:pathology; D004292:Dominance, Cerebral / Q000502:physiology; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009122:Muscle Hypertonia / Q000175:diagnosis; D009367:Neoplasm Staging; D009460:Neurologic Examination; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000473:pathology; D020362:Paraneoplastic Cerebellar Degeneration / Q000175:diagnosis; D020361:Paraneoplastic Syndromes, Nervous System / Q000175:diagnosis*; D014920:Wine / Q000009:adverse effects