Treatment of Staphylococcus aureus biofilm infection by the quorum-sensing inhibitor RIP.
The quorum-sensing inhibitor RIP inhibits staphylococcal TRAP/agr systems and both TRAP- and agr-negative strains are deficient in biofilm formation in vivo, indicating the importance of quorum sensing to biofilms in the host. RIP injected systemically into rats has been found to have strong activity in preventing methicillin-resistant Staphylococcus aureus graft infections, suggesting that RIP can be used as a therapeutic agent.
Balaban
Naomi
N
Department of Biomedical Sciences, Tufts University Cummings School of Veterinary Medicine, 200 Westboro Road, North Grafton, MA 01536, USA. naomi.balaban@tufts.edu
Cirioni
Oscar
O
Giacometti
Andrea
A
Ghiselli
Roberto
R
Braunstein
Joel B
JB
Silvestri
Carmela
C
Mocchegiani
Federico
F
Saba
Vittorio
V
Scalise
Giorgio
G
D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D018441:Biofilms / Q000187:drug effects* / Q000254:growth & development; D004195:Disease Models, Animal; D015964:Gene Expression Regulation, Bacterial; D016106:Methicillin Resistance; D009842:Oligopeptides / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use*; D016459:Prosthesis-Related Infections / Q000188:drug therapy* / Q000382:microbiology; D053038:Quorum Sensing / Q000187:drug effects*; D016601:RNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000382:microbiology; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000235:genetics / Q000254:growth & development; D015534:Trans-Activators / Q000235:genetics / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism; D016896:Treatment Outcome
C095698:Agr protein, Staphylococcus aureus; D001426:Bacterial Proteins; C079092:MtrB protein, Bacteria; D009842:Oligopeptides; D016601:RNA-Binding Proteins; C111711:RNAIII inhibiting peptide; D015534:Trans-Activators; D014157:Transcription Factors