NHC-containing chiral bidentate ligands: synthesis and evaluation in enantioselective copper-catalyzed conjugate addition.
New chiral phosphine-, thiolate-, mesylate-, and tosylate-containing N-heterocyclic carbene ligands have been synthesized in fair to excellent yield. These bidentate ligands have been evaluated in enantioselective copper-catalyzed conjugate addition to both cyclic and acyclic enones and displayed good catalytic activities and poor to good enantiomeric excesses (up to 80%).
Clavier
Hervé
H
UMR CNRS 6226, Sciences Chimiques de Rennes, Ecole Nationale Supérieure de Chimie de Rennes, Av. du Général Leclerc, 35700 Rennes, France.
Guillemin
Jean-Claude
JC
Mauduit
Marc
M