Prevalence of G2P[4] and G12P[6] rotavirus, Bangladesh.
Approximately 20,000 stool specimens from patients with diarrhea visiting 1 urban and 1 rural hospital in Bangladesh during January 2001-May 2006 were tested for group A rotavirus antigen, and 4,712 (24.0%) were positive. G and P genotyping was performed on a subset of 10% of the positive samples (n = 471). During the 2001-2005 rotavirus seasons, G1P[8] (36.4%) and G9P[8] (27.7%) were the dominant strains, but G2[4] and G12P[6] were present in 15.4% and 3.1% of the rotavirus-positive patients, respectively. During the 2005-06 rotavirus season, G2P[4] (43.2%) appeared as the most prevalent strain, and G12P[6] became a more prevalent strain (11.1%) during this season. Because recently licensed rotavirus vaccines include only the P[8] specificity, it is unknown how the vaccines will perform in settings where non-P[8] types are prevalent.
Rahman
Mustafizur
M
International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh. icddrb@gmail.com
Sultana
Rasheda
R
Ahmed
Giasuddin
G
Nahar
Sharifun
S
Hassan
Zahid M
ZM
Saiada
Farjana
F
Podder
Goutam
G
Faruque
Abu S G
AS
Siddique
A K
AK
Sack
David A
DA
Matthijnssens
Jelle
J
Van Ranst
Marc
M
Azim
Tasnim
T
D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral; D001459:Bangladesh / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D003967:Diarrhea / Q000453:epidemiology / Q000821:virology; D005243:Feces / Q000821:virology; D006801:Humans; D007223:Infant; D008875:Middle Aged; D012401:Rotavirus / Q000145:classification*; D012400:Rotavirus Infections / Q000453:epidemiology* / Q000821:virology*; D012621:Seasons
D000914:Antibodies, Viral