title: MicroRNAs and hematopoietic differentiation.
abstract: The discovery of microRNAS (miRNAs) and of their mechanism of action has provided some very new clues on how gene expression is regulated. These studies established new concepts on how posttranscriptional control can fine-tune gene expression during differentiation and allowed the identification of new regulatory circuitries as well as factors involved therein. Because of the wealth of information available about the transcriptional and cellular networks involved in hematopoietic differentiation, the hematopoietic system is ideal for studying cell lineage specification. An interesting interplay between miRNAs and lineage-specific transcriptional factors has been found, and this can help us to understand how terminal differentiation is accomplished.
authors: Institute Pasteur Cenci-Bolognetti, Department of Genetics and Molecular Biology and I.B.P.M., University of Rome La Sapienza, Rome, Italy.
authors: A
authors: A
authors: Fatica
authors: A
authors: A
authors: Rosa
authors: F
authors: F
authors: Fazi
authors: M
authors: M
authors: Ballarino
authors: M
authors: M
authors: Morlando
authors: F G
authors: FG
authors: De Angelis
authors: E
authors: E
authors: Caffarelli
authors: C
authors: C
authors: Nervi
authors: I
authors: I
authors: Bozzoni
mesh_terms: D002454:Cell Differentiation / Q000235:genetics / Q000502:physiology; D018507:Gene Expression Regulation, Developmental; D006410:Hematopoiesis / Q000235:genetics* / Q000502:physiology*; D006801:Humans; D007938:Leukemia / Q000235:genetics / Q000378:metabolism; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism*; D008954:Models, Biological; D012334:RNA, Neoplasm / Q000235:genetics / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism
chemical_list: D035683:MicroRNAs; D012334:RNA, Neoplasm; D014157:Transcription Factors