title: Oligosaccharide-modified poly(propyleneimine) dendrimers: synthesis, structure determination, and Cu(II) complexation.
abstract: The multiple application of reductive amination on primary amino groups of first and second generation poly(propyleneimine) dendrimers is used as a one-pot approach to introduce twice the amount of the oligosaccharide units as surface groups, compared to initially present amino groups in the first and second generation dendrimers. This was proven by (1)H NMR, MALDI-TOF-MS, and LILBID-MS analysis. The size of these dendrimers was determined by the hydrodynamic radius using pulsed field gradient NMR and dynamic light scattering. Molecular modeling confirmed the presence of dense-shell dendrimers. These dendrimers exhibit a generation dependent Cu(II)/dendrimer ratio in an aqueous environment, highlighting these materials as possible metal-carrier systems with a well-defined oligosaccharide protection shell for application in a biological environment.
authors: Leibniz Institute of Polymer Research Dresden, Hohe Strasse 6, Dresden, Germany. applhans@ipfdd.de
authors: Dietmar
authors: D
authors: Appelhans
authors: Yong
authors: Y
authors: Zhong
authors: Hartmut
authors: H
authors: Komber
authors: Peter
authors: P
authors: Friedel
authors: Ulrich
authors: U
authors: Oertel
authors: Ulrich
authors: U
authors: Scheler
authors: Nina
authors: N
authors: Morgner
authors: Dirk
authors: D
authors: Kuckling
authors: Sven
authors: S
authors: Richter
authors: Jürgen
authors: J
authors: Seidel
authors: Bernhard
authors: B
authors: Brutschy
authors: Brigitte
authors: B
authors: Voit
mesh_terms: D003300:Copper / Q000737:chemistry*; D050091:Dendrimers / Q000138:chemical synthesis / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D015394:Molecular Structure; D009844:Oligosaccharides / Q000138:chemical synthesis / Q000737:chemistry; D011126:Polypropylenes / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: D050091:Dendrimers; D009844:Oligosaccharides; D011126:Polypropylenes; C443641:poly(propyleneimine); D003300:Copper