Anti-inflammatory effect of virgin olive oil in stable coronary disease patients: a randomized, crossover, controlled trial.
OBJECTIVE
To assess the effect of two similar olive oils, but with differences in their phenolic compounds (powerful antioxidant compounds), on inflammatory markers in stable coronary heart disease patients.


METHODS
Placebo-controlled, crossover, randomized trial.


METHODS
Cardiology Department of Hospital del Mar and Institut Municipal d'Investigació Mèdica (Barcelona).


METHODS
Twenty-eight stable coronary heart disease patients.


METHODS
A raw daily dose of 50 ml of virgin and refined olive oil (ROO) was sequentially administered over two periods of 3-weeks, preceded by 2-week washout periods in which ROO was used.


RESULTS
Interleukin-6 (P<0.002) and C-reactive protein (P=0.024) decreased after virgin olive oil intervention. No changes were observed in soluble intercellular and vascular adhesion molecules, glucose and lipid profile.


CONCLUSIONS
Consumption of virgin olive oil, could provide beneficial effects in stable coronary heart disease patients as an additional intervention to the pharmacological treatment.
Fitó
M
M
Unitat de Lípids i Epidemiologia Cardiovascular, Institut Municipal d'Investigació Mèdica (IMIM), Barcelona, Spain. mfito@imim.es
Cladellas
M
M
de la Torre
R
R
Martí
J
J
Muñoz
D
D
Schröder
H
H
Alcántara
M
M
Pujadas-Bastardes
M
M
Marrugat
J
J
López-Sabater
M C
MC
Bruguera
J
J
Covas
M I
MI
D000368:Aged; D000975:Antioxidants / Q000008:administration & dosage* / Q000378:metabolism; D002097:C-Reactive Protein / Q000378:metabolism*; D003327:Coronary Disease / Q000097:blood / Q000178:diet therapy*; D018592:Cross-Over Studies; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage* / Q000378:metabolism; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D050356:Lipid Metabolism / Q000187:drug effects; D008297:Male; D000069463:Olive Oil; D010938:Plant Oils / Q000737:chemistry
D000975:Antioxidants; D004042:Dietary Fats, Unsaturated; D015850:Interleukin-6; D000069463:Olive Oil; D010938:Plant Oils; D002097:C-Reactive Protein