Fisher/Gullain-Barré overlap syndrome in advanced AIDS.
Human immunodeficiency virus-associated Guillain-Barré syndrome typically occurs early in HIV infection before AIDS develops. We report a 56-year-old male AIDS patient, who developed overlapping Fisher/Guillain-Barré syndrome despite markedly decreased CD4 cell counts. Serum anti-GQ1b IgG antibody was positive. His condition improved rapidly after immunoglobulin treatment. This indicates that Fisher/Guillain-Barré syndrome may occur even in severely immunosuppressed patients and that anti-ganglioside antibody production is possibly mediated by a T cell-independent process.
Hiraga
Akiyuki
A
Department of Neurology, Asahi General Hospital, Chiba, Japan. hiragaa@yahoo.co.jp
Kuwabara
Satoshi
S
Nakamura
Akira
A
Yuki
Nobuhiro
N
Hattori
Takamichi
T
Matsunaga
Takashi
T
D020275:Guillain-Barre Syndrome / Q000209:etiology* / Q000821:virology; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D008297:Male; D008875:Middle Aged; D019846:Miller Fisher Syndrome / Q000209:etiology* / Q000821:virology