Farnesyl diphosphate synthase: a novel genotype association with bone mineral density in elderly women.
OBJECTIVE
We evaluated the association between a single nucleotide polymorphism in the farnesyl diphosphate synthase gene (FDPS), BMD and bone turnover markers.


METHODS
Two hundred and eighty-three community-dwelling Caucasian women aged 65 or older were screened from the greater Boston area. A validated FDPS SNP (rs2297480, A/C) was genotyped and evaluated for effect on bone mineral density (spine, hip, forearm) and bone turnover markers (urine N-telopeptide cross-linked collagen type 1, osteocalcin and bone-specific alkaline phosphatase).


RESULTS
BMD was lower at all sites measured in women with the C/C or C/A genotypes. Statistically significant differences (p<0.05) were found at the PA spine, trochanter, distal radius, and proximal ulna after adjustment for age and BMI. No significant differences were found in bone turnover markers.


CONCLUSIONS
These findings suggest that a single nucleotide polymorphism in the FDPS gene (rs2297480) may be a genetic marker for lower BMD in postmenopausal Caucasian women.
Levy
Matthew E
ME
Division of Endocrinology and Metabolism and Division of Geriatrics, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, United States. levyme2@upmc.edu
Parker
Robert A
RA
Ferrell
Robert E
RE
Zmuda
Joseph M
JM
Greenspan
Susan L
SL
D000368:Aged; D000469:Alkaline Phosphatase / Q000378:metabolism; D015519:Bone Density; D001900:Boston; D024042:Collagen Type I / Q000652:urine; D005260:Female; D005838:Genotype; D051228:Geranyltranstransferase / Q000235:genetics*; D006801:Humans; D015675:Osteocalcin / Q000378:metabolism; D015663:Osteoporosis, Postmenopausal / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D044465:White People / Q000235:genetics
D024042:Collagen Type I; D015675:Osteocalcin; D051228:Geranyltranstransferase; D000469:Alkaline Phosphatase