title: Antidepressant-like effects of mild hypoxia preconditioning in the learned helplessness model in rats.
abstract: The effects of preconditioning using mild repetitive hypobaric hypoxia (360 Torr for 2 h each of 3 days) have been studied in the learned helplessness model of depression in rats. Male Wistar rats displayed persistent depressive symptoms (depressive-like behaviour in open field, increased anxiety levels in elevated plus maze, ahedonia, elevated plasma glucocorticoids and impaired dexamethasone test) following the exposure to unpredictable and inescapable footshock in the learned helplessness paradigm. Antidepressant treatment (ludiomil, 5 mg/kg i.p.) augmented the development of the depressive state. The hypoxic preconditioning had a clear antidepressive action returning the behavioural and hormonal parameters to the control values and was equally effective in terms of our study as the antidepressant. The findings suggest hypoxic preconditioning as an effective tool for the prophylaxis of post-stress affective pathologies in humans.
authors: Laboratory of Neuroendocrinology, Pavlov Institute of Physiology, Russian Academy of Sciences, Makarova 6, 199034 St. Petersburg, Russian Federation. mos@kolt.infran.ru
authors: Elena
authors: E
authors: Rybnikova
authors: Vera
authors: V
authors: Mironova
authors: Svetlana
authors: S
authors: Pivina
authors: Ekaterina
authors: E
authors: Tulkova
authors: Natalia
authors: N
authors: Ordyan
authors: Ludmila
authors: L
authors: Vataeva
authors: Elena
authors: E
authors: Vershinina
authors: Eugeny
authors: E
authors: Abritalin
authors: Alexandr
authors: A
authors: Kolchev
authors: Natalia
authors: N
authors: Nalivaeva
authors: Anthony J
authors: AJ
authors: Turner
authors: Michail
authors: M
authors: Samoilov
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism / Q000503:physiopathology; D003866:Depressive Disorder / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy*; D004195:Disease Models, Animal; D005938:Glucocorticoids / Q000097:blood; D006380:Helplessness, Learned; D002534:Hypoxia, Brain / Q000378:metabolism* / Q000503:physiopathology; D019194:Ischemic Preconditioning / Q000379:methods*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013315:Stress, Psychological / Q000150:complications / Q000378:metabolism / Q000503:physiopathology; D016896:Treatment Outcome
chemical_list: D005938:Glucocorticoids