title: [Renin-angiotensin and kinin-bradykinin genes polymorphism effects on permanent arterial hypertension in children].
abstract: New methods are required for more objective estimation of the polymorphic genes contribution in multifactorial diseases. We suggest new approach based on the calculation of relative "score" as a sum of relevant genetic polymorphisms studied. Application of suggested approach is evaluated in analysis of the genes REN (19-83G>A), AGT (M235T), ACE (I/D), AGTR1 (1166A>C), AGTR2 (3123C>A), BKR2 (-58T>C and I/D) in children with arterial hypertension. The method proved that polymorphism of renin-angiotensin and kinin-bradikynin gene systems renders essential influence on formation of stably raised arterial pressure in girls.
authors: A S
authors: AS
authors: Glotov
authors: T E
authors: TE
authors: Ivashchenko
authors: G I
authors: GI
authors: Obraztsova
authors: T V
authors: TV
authors: Nasedkina
authors: V S
authors: VS
authors: Baranov
mesh_terms: D000293:Adolescent; D001920:Bradykinin / Q000235:genetics*; D002648:Child; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D008297:Male; D020641:Polymorphism, Single Nucleotide; D012084:Renin-Angiotensin System / Q000235:genetics*; D012737:Sex Factors
chemical_list: D001920:Bradykinin