title: Antimicrobial effects of silver nanoparticles.
abstract: The antimicrobial effects of silver (Ag) ion or salts are well known, but the effects of Ag nanoparticles on microorganisms and antimicrobial mechanism have not been revealed clearly. Stable Ag nanoparticles were prepared and their shape and size distribution characterized by particle characterizer and transmission electron microscopic study. The antimicrobial activity of Ag nanoparticles was investigated against yeast, Escherichia coli, and Staphylococcus aureus. In these tests, Muller Hinton agar plates were used and Ag nanoparticles of various concentrations were supplemented in liquid systems. As results, yeast and E. coli were inhibited at the low concentration of Ag nanoparticles, whereas the growth-inhibitory effects on S. aureus were mild. The free-radical generation effect of Ag nanoparticles on microbial growth inhibition was investigated by electron spin resonance spectroscopy. These results suggest that Ag nanoparticles can be used as effective growth inhibitors in various microorganisms, making them applicable to diverse medical devices and antimicrobial control systems.
authors: Laboratory of Toxicology, Seoul National University, Seoul, Korea.
authors: Jun Sung
authors: JS
authors: Kim
authors: Eunye
authors: E
authors: Kuk
authors: Kyeong Nam
authors: KN
authors: Yu
authors: Jong-Ho
authors: JH
authors: Kim
authors: Sung Jin
authors: SJ
authors: Park
authors: Hu Jang
authors: HJ
authors: Lee
authors: So Hyun
authors: SH
authors: Kim
authors: Young Kyung
authors: YK
authors: Park
authors: Yong Ho
authors: YH
authors: Park
authors: Cheol-Yong
authors: CY
authors: Hwang
authors: Yong-Kwon
authors: YK
authors: Kim
authors: Yoon-Sik
authors: YS
authors: Lee
authors: Dae Hong
authors: DH
authors: Jeong
authors: Myung-Haing
authors: MH
authors: Cho
mesh_terms: D000111:Acetylcysteine / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004578:Electron Spin Resonance Spectroscopy; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development; D008826:Microbial Sensitivity Tests; D053758:Nanoparticles / Q000648:ultrastructure; D012834:Silver / Q000494:pharmacology*; D012835:Silver Nitrate; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development; D013696:Temperature
chemical_list: D000900:Anti-Bacterial Agents; D012834:Silver; D012835:Silver Nitrate; D000111:Acetylcysteine