Artificial protein sensors.
Protein recognition by synthetic molecules is a challenging endeavour, since these materials must bind to a large relatively flat surface domain and recognize a unique distribution of amino acid residues of varying charge, size and shape. The most promising routes involve specific metal coordination, epitope-docking on miniature proteins, aptamer selection, nonnatural peptide isosteres, functionalized platforms, secondary structure mimetics, molecular imprinting and receptors embedded in lipid layers.
Schrader
Thomas
T
University Duisburg-Essen, Department of Chemistry, Universitätsstr. 5, 45117, Essen, Germany.
Koch
Sebastian
S
D052158:Aptamers, Peptide / Q000737:chemistry; D008055:Lipids / Q000737:chemistry; D008670:Metals / Q000737:chemistry; D015394:Molecular Structure; D010455:Peptides / Q000737:chemistry*; D017510:Protein Folding; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000737:chemistry*; D013329:Structure-Activity Relationship
D052158:Aptamers, Peptide; D008055:Lipids; D008670:Metals; D010455:Peptides; D011506:Proteins