title: Diels-Alder cycloaddition approach to puupehenone-related metabolites: synthesis of the potent angiogenesis inhibitor 8-epipuupehedione.
abstract: A new synthetic strategy toward puupehenone-related bioactive metabolites from sclareol oxide, based on a Diels-Alder cycloaddition approach, is described. Utilizing this, marine ent-chromazonarol and the potent angiogenesis inhibitor 8-epipuupehedione have been synthesized.
authors: Departamento de Química OrgAnica, Facultad de Ciencias, Universidad de Granada, 18071 Granada, Spain. eamr@ugr.es
authors: E J
authors: EJ
authors: Alvarez-Manzaneda
authors: R
authors: R
authors: Chahboun
authors: E
authors: E
authors: Cabrera
authors: E
authors: E
authors: Alvarez
authors: A
authors: A
authors: Haidour
authors: J M
authors: JM
authors: Ramos
authors: R
authors: R
authors: Alvarez-Manzaneda
authors: M
authors: M
authors: Hmamouchi
authors: H
authors: H
authors: Bouanou
mesh_terms: D020533:Angiogenesis Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry; D002625:Chemistry, Organic / Q000379:methods*; D012717:Sesquiterpenes / Q000737:chemistry / Q000378:metabolism*; D013729:Terpenes / Q000138:chemical synthesis* / Q000737:chemistry; D014966:Xanthenes / Q000138:chemical synthesis; D044004:Xanthones / Q000737:chemistry / Q000378:metabolism*
chemical_list: C481243:8-epipuupehedione; D020533:Angiogenesis Inhibitors; D012717:Sesquiterpenes; D013729:Terpenes; D014966:Xanthenes; D044004:Xanthones; C121655:chromazonarol; C053594:puupehenone