Human MxA protein confers resistance to double-stranded RNA viruses of two virus families.
The interferon-induced human MxA protein belongs to the dynamin superfamily of large GTPases and accumulates in the cytoplasm. MxA is a key component of the innate antiviral response and has previously been shown to inhibit several viruses with single-stranded RNA genomes of both polarities and a DNA virus. In addition, MxA also targets two double-stranded RNA viruses, Infectious bursal disease virus and a mammalian reovirus as shown in this study. Thus, the antiviral spectrum of human MxA is broader than hitherto suspected. Interestingly, virus growth was not affected in cells expressing MxA(E645R), a mutant form of MxA that showed antiviral activity against orthomyxoviruses.
Mundt
Egbert
E
Institute of Molecular Biology, Friedrich-Loeffler-Institut, 17493 Greifswald-Insel Riems, Germany.
D019943:Amino Acid Substitution; D000818:Animals; D002522:Chlorocebus aethiops; D019204:GTP-Binding Proteins / Q000502:physiology*; D006801:Humans; D007243:Infectious bursal disease virus / Q000254:growth & development* / Q000276:immunology*; D020125:Mutation, Missense; D064547:Myxovirus Resistance Proteins; D030102:Orthoreovirus, Mammalian / Q000254:growth & development* / Q000276:immunology*; D014709:Vero Cells; D014779:Virus Replication
C579071:MX1 protein, human; D064547:Myxovirus Resistance Proteins; D019204:GTP-Binding Proteins