title: Syntheses and antiproliferative evaluation of oxyphenisatin derivatives.
abstract: Syntheses and structure-antiproliferative relationship for oxyphenisatin analogues are described. The cell proliferation data showed that the presence of substituents (especially F, Cl, Me, CF(3), and OMe) in the 6- and 7-position of oxyphenisatin markedly enhanced the potency in the MDA-468 cell line without affecting the MDA-231 cell line. The best compounds from this series showed low nanomolar antiproliferative activity towards the MDA-468 cell line and a 1000-fold selectivity over the MDA-231 cell line.
authors: Evotec(UK) Ltd, 111 Milton Park, Abingdon, Oxon OX14 4RX, UK.
authors: Muhammed K
authors: MK
authors: Uddin
authors: Serge G
authors: SG
authors: Reignier
authors: Tom
authors: T
authors: Coulter
authors: Christian
authors: C
authors: Montalbetti
authors: Charlotta
authors: C
authors: Grånäs
authors: Steven
authors: S
authors: Butcher
authors: Christian
authors: C
authors: Krog-Jensen
authors: Jakob
authors: J
authors: Felding
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects*; D006801:Humans; D015394:Molecular Structure; D010114:Oxyphenisatin Acetate / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; C560641:Top001 compound; C560642:Top216 compound; D010114:Oxyphenisatin Acetate