title: Characterization of PsTX-60B, a new membrane-attack complex/perforin (MACPF) family toxin, from the venomous sea anemone Phyllodiscus semoni.
abstract: The sea anemone Phyllodiscus semoni has been known as one of the most venomous sea anemones. Previously, we reported the isolation of the major lethal protein toxins, PsTX-60A and PsTX-60B, from P. semoni and the primary structure of PsTX-60A. In this paper, we report the complete sequence of cDNA (1600 base pairs) encoding PsTX-60B and the deduced primary structure (488 amino acids) of PsTX-60B. The amino acid sequence of PsTX-60B showed the homology with those of PsTX-60A and Actineria villosa toxin, AvTX-60A. The results showed that PsTX-60B is a new member of the membrane-attack complex/perforin (MACPF) family toxin.
authors: Tokyo University of Marine Science and Technology, 4-5-7 Konan, Minato-ku, Tokyo 108-8477, Japan.
authors: Hiroshi
authors: H
authors: Satoh
authors: Naomasa
authors: N
authors: Oshiro
authors: Setsuko
authors: S
authors: Iwanaga
authors: Michio
authors: M
authors: Namikoshi
authors: Hiroshi
authors: H
authors: Nagai
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D003064:Cnidarian Venoms / Q000235:genetics*; D018076:DNA, Complementary / Q000235:genetics; D008969:Molecular Sequence Data; D054353:Perforin / Q000235:genetics*; D012615:Sea Anemones / Q000737:chemistry*; D017422:Sequence Analysis, DNA; D017385:Sequence Homology
chemical_list: D003064:Cnidarian Venoms; D018076:DNA, Complementary; D054353:Perforin