title: Organocatalytic enantioselective nucleophilic vinylic substitution by alpha-substituted-alpha-cyanoacetates under phase-transfer conditions.
abstract: The organocatalytic enantioselective formation of vinyl-substituted all-carbon quaternary stereocenters via nucleophilic vinylic substitution by alpha-substituted-alpha-cyanoacetates is presented. The reaction proceeds well for different alpha-substituted-alpha-cyanoacetates and beta-chloroalkenones using a dimeric cinchona alkaloid phase-transfer catalyst giving the products in good yield and with enantioselectivities up to 98% ee.
authors: Danish National Research Foundation: Center for Catalysis, Department of Chemistry, Aarhus University, DK-8000 Aarhus C, Denmark.
authors: Mark
authors: M
authors: Bell
authors: Thomas B
authors: TB
authors: Poulsen
authors: Karl Anker
authors: KA
authors: Jørgensen