title: [Alveolar hemorrhage secondary to generalized systemic lupus erithematosus treated with recombinant activated factor VII. Case report and literature review].
abstract: Alveolar hemorrhage is a severe complication of systemic lupus erithematosus (SLe) associated with high mortality. Treatment includes administration of steroids and cyclophosphamide. Additionally, some reports have recommended the use of plasmapheresis, azathioprine and methotrexate. There is a single case reported in the literature in which recombinant activatedfactor VII (rFVIIa) was used to control severe hemorrhage secondary to alveolitis unresponsive to standard treatment. We report the case of a patient with SLE who developed severe alveolar hemorrhage unresponsive to standard measures, but who was successfully treated with rFVIIa.
authors: Unidad de Terapia Intensiva, Hospital Angeles Lomas, Vialidad de la Barranca s/n, Colonia Valle de las Palmas, 52763, Huixquilucan, Estado de México, México. seconcapcma@mail.medinet.net.mx
authors: Raúl
authors: R
authors: Carrillo-Esper
authors: Sandra
authors: S
authors: Elizondo-Argueta
authors: Martín de Jesús
authors: Mde J
authors: Sánchez-Zúñiga
authors: Jorge Raúl
authors: JR
authors: Carrillo-Córdova
mesh_terms: D000293:Adolescent; D015942:Factor VIIa / Q000627:therapeutic use*; D005260:Female; D006470:Hemorrhage / Q000188:drug therapy* / Q000209:etiology*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications*; D011994:Recombinant Proteins / Q000627:therapeutic use*
chemical_list: D011994:Recombinant Proteins; D015942:Factor VIIa