title: Circadian variation in restless legs syndrome.
abstract: Restless legs syndrome (RLS) is a clinical disorder that currently is not characterized by a uniform pathophysiologiocal definition. The diagnosis of RLS requires circadian variation in symptoms, although no pathophysiological basis has been verified. Clinical observations and research studies confirm the variation in symptoms, of both sensory and motor components, over the course of the day. This contribution reviews the current literature on circadian variation in RLS and discusses potential intrinsic and extrinsic causes.
authors: Department of Clinical Neurophysiology, Georg August University of Göttingen, Göttingen, Germany. pbaier@gwdg.de
authors: P C
authors: PC
authors: Baier
authors: C
authors: C
authors: Trenkwalder
mesh_terms: D000818:Animals; D002940:Circadian Rhythm / Q000502:physiology; D004298:Dopamine / Q000378:metabolism; D006801:Humans; D006930:Hyperalgesia / Q000209:etiology; D007501:Iron / Q000378:metabolism; D011388:Prolactin / Q000378:metabolism; D012148:Restless Legs Syndrome / Q000175:diagnosis* / Q000503:physiopathology*; D012894:Sleep Stages / Q000502:physiology; D014851:Wakefulness / Q000502:physiology
chemical_list: D011388:Prolactin; D007501:Iron; D004298:Dopamine