Value of chemical mixture in multiple supralethal X-irradiation of mice.
A chemical mixture containing 25 Amoles of MEA, 7 pmoles of AET, and 2 micromoles of 5-HT was found to be of significant value in protecting mice against repeated exposures of 800 R, 1100 R, or 1400 R given at intervals of 28 days. Dose-reduction factors of 2.17, 2.18, 1.95, 2.14, and 1.58 were obtained for the first five exposures. Following the first exposure there was no chemical mortality. The beneficial value of this mixture, however, was limited by the incidence of chemical toxicity which was more prevalent in mice with higher cumulative doses of radiation.
Wang
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Veterans Administration Center, Wood, Wisconsin, USA.
Hasegawa
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D000818:Animals; D003543:Cysteamine / Q000008:administration & dosage*; D004307:Dose-Response Relationship, Radiation; D004338:Drug Combinations; D051379:Mice; D008813:Mice, Inbred ICR; D011829:Radiation Dosage; D011836:Radiation Tolerance / Q000187:drug effects*; D011837:Radiation-Protective Agents / Q000008:administration & dosage*; D012701:Serotonin / Q000008:administration & dosage*; D016019:Survival Analysis; D015996:Survival Rate; D014965:X-Rays / Q000009:adverse effects*; D000338:beta-Aminoethyl Isothiourea / Q000008:administration & dosage*
D004338:Drug Combinations; D011837:Radiation-Protective Agents; D000338:beta-Aminoethyl Isothiourea; D012701:Serotonin; D003543:Cysteamine