title: Modulatory action of combined treatment with antibodies against S100 protein and low doses of this protein on membrane effects of quinine.
abstract: Antibodies against calcium-binding protein S100 (AB-S100) 1.5-fold increased, while quinine 2-fold decreased the frequency of action potential generation in B4 and B6 neurons. Application of quinine against the background of AB-S100 treatment returned this parameter to the initial level. Pretreatment with AB-S100 in low doses prevents changes the frequency of action potential generation induced by application of AB-S100 in the initial dilution. The duration of action potential increased by 1.6 times after application of AB-S100 and quinine, while after application of quinine increased this parameter by more than 6 times. AB-S100 decreased maximum inward current by 20%. Our experiments demonstrated a modulating effect of combined administration of AB-S100 and its low doses on the membrane effects of quinine.
authors: Materia Medica Holding Research-and-Production Company, Moscow.
authors: O I
authors: OI
authors: Epstein
authors: M B
authors: MB
authors: Shtark
authors: V V
authors: VV
authors: Andrianov
authors: Kh L
authors: KhL
authors: Gainutdinov
authors: T Kh
authors: TKh
authors: Gainutdinova
authors: D I
authors: DI
authors: Silant'eva
mesh_terms: D000200:Action Potentials / Q000187:drug effects* / Q000502:physiology; D000818:Animals; D000906:Antibodies / Q000494:pharmacology*; D002462:Cell Membrane / Q000187:drug effects; D006372:Helix, Snails / Q000502:physiology*; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D011803:Quinine / Q000494:pharmacology*; D009418:S100 Proteins / Q000276:immunology*; D018709:Statistics, Nonparametric
chemical_list: D000906:Antibodies; D009418:S100 Proteins; D011803:Quinine