Peptidergic correction of behavior in adult progeny of albino rats exposed to acute hypoxia during early organogenesis.
Physical development, spontaneous behavior, and training capacity were evaluated in adult progeny of albino rats exposed to acute hypobaric hypoxia on days 9-10 of gestation, corresponding to the early organogenesis period. Prenatal hypoxia caused delayed behavioral disorders, which were more pronounced in females born from mothers with low resistance to hypoxia. Therapeutic intranasal administration of Pro-Gly-Pro peptide in a dose of 1 mg/kg to rat pups on days 13-15 of life completely prevented the negative consequences of acute prenatal hypoxia in adult females and leveled virtually all negative consequences, except delayed physical development, in males.
Graf
A V
AV
Department of Physiology of Man and Animals, Biological Faculty, M. V. Lomonosov Moscow State University.
Maklakova
A S
AS
Krushinskaya
Ya V
YV
Sokolova
N A
NA
D000818:Animals; D005260:Female; D000860:Hypoxia / Q000150:complications* / Q000503:physiopathology*; D008297:Male; D001523:Mental Disorders / Q000188:drug therapy* / Q000209:etiology; D009842:Oligopeptides / Q000627:therapeutic use*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000503:physiopathology*; D011392:Proline / Q000031:analogs & derivatives* / Q000627:therapeutic use; D051381:Rats; D012309:Risk-Taking
D009842:Oligopeptides; C113164:prolyl-glycyl-proline; D011392:Proline