Increased hippocampal atrophy rates in AD over 6 months using serial MR imaging.
We measured hippocampi on baseline-, 6- and 12-month scans in a group of AD (n=36) and control subjects (n=20). We found that mean annualised atrophy rates using 6-month intervals were comparable at a group level to those generated from a 12-month interval. Higher variance was seen using shorter intervals, although this was only significant in the control group. This has implications where shorter inter-scan intervals may be advantageous, such as rapid diagnosis, and tracking of disease progression including in a clinical trial.
Barnes
J
J
Dementia Research Centre, UCL, Institute of Neurology, London, United Kingdom. j.barnes@dementia.ion.ucl.ac.uk
Scahill
R I
RI
Frost
C
C
Schott
J M
JM
Rossor
M N
MN
Fox
N C
NC
D000368:Aged; D000375:Aging / Q000473:pathology*; D000544:Alzheimer Disease / Q000473:pathology*; D001284:Atrophy / Q000473:pathology; D001921:Brain / Q000473:pathology*; D005260:Female; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D013382:Subtraction Technique