title: Three major urinary metabolites of sinomenine in rats.
abstract: Urinary metabolites of sinomenine were investigated in rats after intragastric administration. Three major metabolites were obtained and characterised as 4-hydroxy-3,7,7-trimethoxy-17-methyl-(9alpha,13alpha,14alpha)-morphinan-6-one (1), 7,8-didehydro-4-hydroxy-3,7-dimethoxy-17-methyl-N-oxide-(9alpha,13alpha,14alpha)-morphinan-6-one (2), and 7,8-didehydro-4-hydroxy-3,7-dimethoxy-(9alpha,13alpha,14alpha)-morphinan-6-one (3). Their structures have been elucidated on the base of spectral analysis, among which 1 and 2 were new compounds.
authors: Department of Natural Products Chemistry, Shenyang Pharmaceutical University, Shenyang, China.
authors: W-M
authors: WM
authors: Cheng
authors: F
authors: F
authors: Qiu
authors: X-S
authors: XS
authors: Yao
mesh_terms: D000818:Animals; D004365:Drugs, Chinese Herbal; D008297:Male; D015394:Molecular Structure; D009019:Morphinans / Q000737:chemistry* / Q000652:urine*; D019906:Nuclear Magnetic Resonance, Biomolecular; D051381:Rats; D017208:Rats, Wistar; D013056:Spectrophotometry, Ultraviolet
chemical_list: D004365:Drugs, Chinese Herbal; D009019:Morphinans; C009271:sinomenine