Imidazo[1,2-a]pyridines with potent activity against herpesviruses.
Synthesis of a series of 2-aryl-3-pyrimidyl-imidazo[1,2-a]pyridines with potent activity against herpes simplex viruses is described. Synthetic approaches allowing for variation of the 2-aryl, 3-heteroaryl as well as other imidazopyridine substituents are outlined and resulting effects on antiviral activity are highlighted. Several compounds with in vitro antiviral activity similar or better than acyclovir are described.
Gudmundsson
Kristjan S
KS
Department of Medicinal Chemistry, Infectious Diseases Center of Excellence for Drug Discovery, GlaxoSmithKline Research & Development, Five Moore Drive, Research Triangle Park, NC 27709-3398, USA. Kristjan.S.Gudmundsson@gsk.com
Johns
Brian A
BA
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D006564:Herpesviridae / Q000187:drug effects*; D007093:Imidazoles / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D011725:Pyridines / Q000737:chemistry; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology
D000998:Antiviral Agents; D007093:Imidazoles; D011725:Pyridines; D011743:Pyrimidines