title: Angioedema in renal transplant recipients on sirolimus.
abstract: BACKGROUND
  Most drug-associated angioedemas are induced by angiotensin-converting enzyme inhibitors, angiotensin II receptor antagonists, or nonsteroidal anti-inflammatory drugs. Recently, the responsibility of immunosuppressive agents given to transplant recipients in the development of angioedema has been discussed.
  
  
  OBJECTIVE
  To describe, in detail, angioedema episodes in renal transplant recipients (RTRs) on sirolimus.
  
  
  METHODS
  A cross-sectional study in a university hospital. Eighty consecutive RTRs on sirolimus were studied.
  
  
  RESULTS
  Angioedema without urticaria occurred a mean of 5 times in 12/80 (15%) RTRs taking sirolimus. It was predominantly located on the face (83%), with mucous membrane involvement in 7 (58%) patients, and was life threatening in 1. Another putative cofactor for angioedema without urticaria was identified in 9 (75%) patients: drugs (n=8), food allergy or physical activity (n=3). Tacrolimus intake was significantly associated with sirolimus-associated angioedema.
  
  
  CONCLUSIONS
  Our results suggested a causal relationship between sirolimus and angioedema in RTRs.
authors: Department of Dermatology, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Paris, France. emmanuel.mahe@apr.aphp.fr
authors: Emmanuel
authors: E
authors: Mahé
authors: Emmanuel
authors: E
authors: Morelon
authors: Sophie
authors: S
authors: Lechaton
authors: Henri
authors: H
authors: Kreis
authors: Yves
authors: Y
authors: de Prost
authors: Christine
authors: C
authors: Bodemer
mesh_terms: D000799:Angioedema / Q000139:chemically induced*; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D005148:Facial Dermatoses / Q000139:chemically induced; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D020123:Sirolimus / Q000009:adverse effects*
chemical_list: D007166:Immunosuppressive Agents; D020123:Sirolimus