title: Temporomandibular disorder is associated with a serotonin transporter gene polymorphism in the Japanese population.
abstract: OBJECTIVE
  Recent genetic studies have linked serotonin-related genetic polymorphisms with diverse disorders characterized by functional somatic symptoms, including chronic fatigue syndrome, irritable bowel syndrome, and premenstrual dysphoric disorder.
  
  
  METHODS
  We investigated three serotonin-related genetic polymorphisms by screening genomic DNA of 36 temporomandibular disorder (TMD) patients.
  
  
  RESULTS
  A significant increase of longer alleles (l and xl) was found in the TMD patients compared to the controls both by the genotype-wise and the allele-wise analyses (both p < 0.01 by chi(2) test and Fisher's exact test).
  
  
  CONCLUSIONS
  Genetic factors that involve the serotonergic system may play a role in the pathogenesis of TMD.
authors: Graduate School Human Sciences, University of Tsukuba, Ibaraki, Japan.
authors: Kiyomi
authors: K
authors: Ojima
authors: Nagaoki
authors: N
authors: Watanabe
authors: Naoko
authors: N
authors: Narita
authors: Masaaki
authors: M
authors: Narita