Is it a pheochromocytoma?
The patient is a 44-year-old man with a 4-year history of intermittently elevated blood pressure (BP) controlled by diet and exercise. Three months before evaluation he described daily "spikes" of BP with sharp unilateral headaches. He was seen in the emergency department with a BP of 212/106 mm Hg and was started on hydrochlorothiazide 25 mg daily. He denied palpitations, diaphoretic episodes, pallor, and tremor. The patient did not want to take medication and specifically requested an evaluation to rule out pheochromocytoma. Results from 24-hour urine tests for total metanephrines was 812 mg/24 h (normal, 130-520 mg/24 h), for total catecholamines was 53 mg/24 h (normal, 0-135 mg/24 h), and for vanillylmandelic acid was 4.7 mg/24 h (normal, <7 mg/24 h). Thyroid-stimulating hormone was 0.87 (normal, 0.4-4.0 IU/mL). Physical examination revealed normal optic fundi, negative cardiac examination results, and presence of peripheral pulses without bruits. His BP was now 136/74 mm Hg, with a heart rate of 76 beats per minute.
Handler
Joel
J
Kaiser Permanente, Anaheim, CA 92807, USA. joel.handler@kp.org
D000310:Adrenal Gland Neoplasms / Q000150:complications* / Q000175:diagnosis* / Q000503:physiopathology / Q000652:urine; D000328:Adult; D014408:Biomarkers, Tumor / Q000652:urine; D001794:Blood Pressure; D002395:Catecholamines / Q000652:urine; D006339:Heart Rate; D006801:Humans; D006973:Hypertension / Q000209:etiology* / Q000503:physiopathology; D008297:Male; D008676:Metanephrine / Q000652:urine; D010673:Pheochromocytoma / Q000150:complications* / Q000175:diagnosis* / Q000503:physiopathology / Q000652:urine; D014642:Vanilmandelic Acid / Q000652:urine
D014408:Biomarkers, Tumor; D002395:Catecholamines; D008676:Metanephrine; D014642:Vanilmandelic Acid