Continuous veno-venous hemofiltration in the treatment of acute severe hyponatremia: a report of 11 cases.
OBJECTIVE
To evaluate the treatment effect of continuous veno-venous hemofiltration (CVVH) in patients with acute severe hyponatremia.


METHODS
Eleven patients with severe acute hyponatremia, including 6 males and 5 females, aged 25-61 years (mean age 48.36), were treated with CVVH. Hyponatremia occurred 38-48 hours prior to the initiation of CVVH.


RESULTS
All patients tolerated CVVH well, with an average treatment duration of 57.19 (45.6-86) hours. During CVVH, the serum sodium concentration increased significantly from 100.9+/-3.99 mmol/L at initiation of CVVH to 140.3+/-1.6 mmol/L after 48 hours of treatment (P<0.01). The serum osmolarity increased concurrently, from 216.7+/-7.4 mOsm/kgH2O to 295.0+/-4.2 mOsm/kgH2O (P<0.01). The Glasgow scores and APACHE II scores in these patients improved significantly during treatment.


CONCLUSIONS
CVVH is a safe and effective option for the treatment of patients with severe acute hyponatremia due to its slow and continuous nature.
Ji
D X
DX
Research Institute of Nephrology, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China.
Gong
D H
DH
Xu
B
B
Tao
J
J
Ren
B
B
Zhang
Y D
YD
Liu
Y
Y
Hu
W X
WX
Wang
M M
MM
Li
L S
LS
D000208:Acute Disease; D000328:Adult; D005260:Female; D006440:Hemofiltration; D006801:Humans; D007010:Hyponatremia / Q000097:blood / Q000209:etiology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009994:Osmolar Concentration; D012964:Sodium / Q000097:blood
D012964:Sodium