[Effects of osteogenic growth peptide on bone density adjacent to implant in irradiated tibia of the rabbits].
OBJECTIVE
To evaluate the effect of radiation and osteogenic growth peptide(OGP) on the bone density adjacent to the implants.


METHODS
24 rabbits underwent 48 implants placed in the tibia, then the rabbits were divided into one control group and two experimental groups randomly. Rabbits in one of the experimental groups were injected with OGP Sol, rabbits in the other groups were injected with normal saline; Then rabbits in the two experimental groups received radiation after the implant wound healed. 12 rabbits were sacrificed at 4 weeks and 16 weeks respectively. The samples were observed with gross, X-ray, histological examination. The data was analysed for Dunnett t test using SPSS13.0 software package.


RESULTS
At 4 weeks, the bone density adjacent to the implant of the simple irradiation group was significantly less than that of the control group (P<0.05), while the difference was not significant between the irradiation and OGP group and the control group. At 16 weeks, the difference among the three groups wasn't significant.


CONCLUSIONS
Radiation has considerable adverse effect on osteogenesis adjacent to the implants, while systemically administering OGP plays significant roles in the osteogensis of the irradiated rabbit tibia.
Chen
Xiao-Li
XL
Department of Stomatology, Zhongshan Hospital, Xiamen University, Xiamen 361004, Fujian Province, China.
Li
Zhong-Lin
ZL
Zhang
Wen-Bin
WB
Ye
Zhan-Chao
ZC
Ke
Shu-Nv
SN
D000818:Animals; D015519:Bone Density / Q000187:drug effects*; D015921:Dental Implants; D006657:Histones; D036341:Intercellular Signaling Peptides and Proteins; D016348:Osseointegration; D010012:Osteogenesis / Q000528:radiation effects*; D011817:Rabbits; D013977:Tibia / Q000528:radiation effects
D015921:Dental Implants; D006657:Histones; D036341:Intercellular Signaling Peptides and Proteins; C074533:osteogenic growth peptide