Chymotrypsin inhibitory constituents from Haloxylon recurvum.
Haloxylase, the triglyceride (1), unsaturated fatty acid (2), and saturated fatty acid methyl ester (3) have been isolated from the chloroform-soluble fraction of Haloxylon recurvum. Their structures have been elucidated through spectroscopic studies and chemical transformation. All these compounds showed significant inhibitory activity against the enzyme chymotrypsin in a concentration dependent fashion.
Ahmed
Ejaz
E
International Center for Chemical Sciences, HEJ Research Institute of Chemistry, University of Karachi, Karachi, Pakistan.
Malik
Abdul
A
Afza
Nighat
N
Riaz
Naheed
N
Anis
Itrat
I
Sharif
Ahsan
A
Farheen
Sadia
S
Lodhi
Muhammad Arif
MA
Choudhary
Muhammad Iqbal
MI
D019663:Chenopodiaceae / Q000737:chemistry*; D002918:Chymotrypsin / Q000037:antagonists & inhibitors* / Q000378:metabolism; D005231:Fatty Acids, Unsaturated / Q000737:chemistry / Q000302:isolation & purification; D013058:Mass Spectrometry; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009904:Optical Rotation; D010084:Oxidation-Reduction; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D011480:Protease Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D014280:Triglycerides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D005231:Fatty Acids, Unsaturated; D010936:Plant Extracts; D011480:Protease Inhibitors; D014280:Triglycerides; D002918:Chymotrypsin