Physiology of tmRNA: what gets tagged and why?
Transfer-messenger RNA (tmRNA) enters stalled translational complexes and, with small protein B (SmpB), mediates peptide tagging of the nascent protein and release of the stalled ribosome. Recent studies clarify how the tmRNA system is targeted to ribosomes and suggest that tmRNA-tagging is used for both quality control and specific regulation of cellular physiology.
Keiler
Kenneth C
KC
401 Althouse Laboratory, Penn State University, University Park, PA 16827, USA. kkeiler@psu.edu
D001419:Bacteria / Q000235:genetics*; D018407:Bacterial Physiological Phenomena; D012329:RNA, Bacterial / Q000502:physiology*; D012333:RNA, Messenger / Q000502:physiology; D016601:RNA-Binding Proteins / Q000502:physiology; D012270:Ribosomes / Q000502:physiology
D012329:RNA, Bacterial; D012333:RNA, Messenger; D016601:RNA-Binding Proteins; C430328:small protein B; C096222:tmRNA