title: Thalassospiramides A and B, immunosuppressive peptides from the marine bacterium Thalassospira sp.
abstract: [structure: see text] Two new cyclic peptides, thalassospiramides A and B (1 and 2), were isolated from a new member of the marine alpha-proteobacterium Thalassospira. The thalassospiramides, the structures of which were assigned by combined spectral and chemical methods, bear unusual gamma-amino acids and show immunosuppressive activity in an interleukin-5 production inhibition assay (IC50 = 5 muM for thalassospiramide B).
authors: Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California-San Diego, La Jolla, California 92093, USA.
authors: Dong-Chan
authors: DC
authors: Oh
authors: Wendy K
authors: WK
authors: Strangman
authors: Christopher A
authors: CA
authors: Kauffman
authors: Paul R
authors: PR
authors: Jensen
authors: William
authors: W
authors: Fenical
mesh_terms: D000586:Amination; D000818:Animals; D006900:Hydroxylation; D007166:Immunosuppressive Agents / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D008214:Lymphocytes / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D015394:Molecular Structure; D009792:Oceans and Seas; D010421:Pentanoic Acids / Q000737:chemistry; D010456:Peptides, Cyclic / Q000096:biosynthesis / Q000737:chemistry* / Q000494:pharmacology; D012244:Rhodospirillaceae / Q000737:chemistry* / Q000378:metabolism
chemical_list: D007166:Immunosuppressive Agents; D010421:Pentanoic Acids; D010456:Peptides, Cyclic; C520245:thalassospiramide A; C520244:thalassospiramide B