Large cell neuroendocrine carcinoma of the uterine cervix associated with adenocarcinoma.
OBJECTIVE
Large cell neuroendocrine carcinoma (LCNEC) is a rare and aggressive cervical neoplasm. In the present study, we present a 45-year-old woman with large cell neuroendocrine uterine cervical carcinoma with coexisting adenocarcinoma.


METHODS
A 45-year-old G2 P0 presented with vaginal bleeding for 7 months. On pelvic examination, a polypoid mass of the cervix was discovered. Biopsy of the lesion revealed large cell neuroendocrine carcinoma of the cervix. The patient underwent a radical hysterectomy, and then received concurrent chemotherapy and radiation therapy. She has remained disease free until the time of this writing.


CONCLUSIONS
Patients with LCNEC of the cervix have had poor prognoses; hence aggressive multimodality treatment is recommended.
Ko
Ma-Lee
ML
Department of Obstetrics and Gynecology, Cathay General Hospital, Taipei, Taiwan.
Jeng
Cherng-Jye
CJ
Huang
Shih-Hung
SH
Shen
Jenta
J
Chen
Su-Chee
SC
Tzeng
Chii-Ruey
CR
D000230:Adenocarcinoma / Q000175:diagnosis* / Q000628:therapy; D018278:Carcinoma, Neuroendocrine / Q000175:diagnosis* / Q000628:therapy; D002584:Cervix Uteri / Q000473:pathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis* / Q000628:therapy; D016896:Treatment Outcome; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis* / Q000628:therapy