Nanometer-scale patterned surfaces for control of cell adhesion.
A novel cell-adhesion surface, controlled by nanometer-scale topography and chemical patterning, was developed using semiconductor fabrication methods and the formation of self-assembled monolayers. The patterned surface had a sharp contrast between the adsorption and non-adsorption of proteins and cells, and the contrast could be maintained for more than 10 days. The patterning method could easily realize a single cell array and control of the cell morphology. The nanometer-scale patterned surface could control cell adhesion and proliferation. Using the patterned surface will contribute to studies about cell-surface interactions.
Goto
Makiko
M
Department of Applied Chemistry, School of Engineering, The University of Tokyo, Japan.
Tsukahara
Takehiko
T
Sato
Kae
K
Konno
Tomohiro
T
Ishihara
Kazuhiko
K
Sato
Kiichi
K
Kitamori
Takehiko
T
D000818:Animals; D002448:Cell Adhesion; D018929:Cell Culture Techniques / Q000295:instrumentation* / Q000379:methods; D005347:Fibroblasts / Q000166:cytology*; D051379:Mice; D041681:NIH 3T3 Cells; D036103:Nanotechnology / Q000295:instrumentation* / Q000379:methods*