title: Isolation and syntheses of polymethoxyflavones and hydroxylated polymethoxyflavones as inhibitors of HL-60 cell lines.
abstract: Fifteen polymethoxyflavones (PMFs) and hydroxylated PMFs were isolated from sweet orange (Citrus sinensis) peel extract and synthesized to investigate their biological activity. All obtained compounds were tested in HL-60 cancer cell proliferation and apoptosis induction assays. While some PMFs and hydroxylated PMFs had moderate anti-carcinogenic activities, 5-hydroxy-6,7,8,3',4'-pentamethoxyflavone and 5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone showed strong inhibitory activities against the proliferation and induced apoptosis of HL-60 cell lines.
authors: Department of Food Science, Rutgers University, 65 Dudley Road, New Brunswick, NJ 08901-8520, USA. shiming.li@roche.com
authors: Shiming
authors: S
authors: Li
authors: Min-Hsiung
authors: MH
authors: Pan
authors: Ching-Shu
authors: CS
authors: Lai
authors: Chih-Yu
authors: CY
authors: Lo
authors: Slavik
authors: S
authors: Dushenkov
authors: Chi-Tang
authors: CT
authors: Ho
mesh_terms: D016588:Anticarcinogenic Agents / Q000138:chemical synthesis / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis* / Q000302:isolation & purification / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D002957:Citrus / Q000737:chemistry*; D047309:Flavones / Q000302:isolation & purification / Q000502:physiology*; D005638:Fruit / Q000737:chemistry; D018922:HL-60 Cells; D006801:Humans; D006900:Hydroxylation; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D010936:Plant Extracts / Q000737:chemistry; D021241:Spectrometry, Mass, Electrospray Ionization; D013056:Spectrophotometry, Ultraviolet
chemical_list: D016588:Anticarcinogenic Agents; D000972:Antineoplastic Agents, Phytogenic; D047309:Flavones; D007202:Indicators and Reagents; D010936:Plant Extracts