title: Long-term results of repair of anomalous origin of the left coronary artery from the pulmonary artery.
abstract: BACKGROUND
  Upon initial repair, most patients with anomalous origin of the left coronary artery from the pulmonary artery (ALCAPA) present with severely impaired ventricular function and mitral regurgitation. In this study, both parameters were investigated at long-term in patients in whom either coronary transfer or subclavian artery anastomosis was applied.
  
  
  METHODS
  Records of 56 patients with ALCAPA, operated between 1977 and 2002, were reviewed retrospectively. Patients were divided into two groups: subclavian artery anastomosis group (n = 25), and coronary transfer group (n = 31).
  
  
  RESULTS
  Concomitant mitral valve repair was performed in one patient. Thirty-day mortality was 14.3% (subclavian artery anastomosis group, n = 3; coronary transfer group, n = 5). Preoperative age (p = 0.007) and left ventricular ejection fraction (LVEF) less than 0.35 (p = 0.020) were predictive for 30-day mortality, whereas preoperative mitral regurgitation, surgical technique, and cardiopulmonary bypass time were not. For both groups, LVEF (p = 0.006) and mitral regurgitation (p = 0.013) were improved at the time of hospital discharge. Mean follow-up was 11.0 +/- 7.2 years. Survival of hospital survivors at 20 years was 94.8 +/- 3.6%. At final follow-up, 95.5% of the patients presented with a LVEF greater than 0.50, and 84.1% with a mitral regurgitation less than grade 2. Mitral valve replacement was performed in three patients.
  
  
  CONCLUSIONS
  In the majority of patients with ALCAPA, both ventricular function and mitral valve regurgitation normalize over time. Concomitant mitral reconstruction may not be required upon initial repair. Coronary transfer is the technique of choice today. However, subclavian artery anastomosis may remain an option in selected cases.
authors: Department of Cardiovascular Surgery, German Heart Center Munich, Technical University Munich, Munich, Germany.
authors: Rüdiger
authors: R
authors: Lange
authors: Manfred
authors: M
authors: Vogt
authors: Jürgen
authors: J
authors: Hörer
authors: Julie
authors: J
authors: Cleuziou
authors: Andrea
authors: A
authors: Menzel
authors: Klaus
authors: K
authors: Holper
authors: John
authors: J
authors: Hess
authors: Christian
authors: C
authors: Schreiber
mesh_terms: D000714:Anastomosis, Surgical; D002648:Child; D002675:Child, Preschool; D017023:Coronary Angiography; D003330:Coronary Vessel Anomalies / Q000000981:diagnostic imaging / Q000401:mortality / Q000601:surgery*; D015150:Echocardiography, Doppler; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008944:Mitral Valve Insufficiency / Q000000981:diagnostic imaging / Q000401:mortality / Q000601:surgery*; D015999:Multivariate Analysis; D011183:Postoperative Complications / Q000453:epidemiology; D011336:Probability; D011651:Pulmonary Artery / Q000002:abnormalities*; D012189:Retrospective Studies; D018570:Risk Assessment; D015996:Survival Rate; D013997:Time Factors; D016896:Treatment Outcome; D014656:Vascular Surgical Procedures / Q000009:adverse effects / Q000379:methods*