Acute phase proteins and oxidised low-density lipoprotein in association with ischemic stroke subtype, severity and outcome.
OBJECTIVE
The goal of our study was to investigate the associations of oxidized LDL (apoB100 aldehyde-modified form) and acute phase proteins (fibrinogen, CRP) with acute ischemic stroke severity and outcome.


METHODS
The study included 61 ischemic stroke patients and 64 controls. Strokes were subtyped according to TOAST criteria, the severity and outcome of stroke (at 1 year) were measured.


RESULTS
The mean triglyceride, fibrinogen, CRP and glucose values were significantly higher among cases. The median oxLDL value for patients with large artery atherosclerosis (LAA) type of stroke was significantly higher than for other subtypes. The oxLDL values did not correlate with age, stroke severity and outcome.


CONCLUSIONS
Inflammatory markers (fibrinogen and CRP) predicted the stroke severity and outcome whereas elevation of oxLDL levels did not. Our data refer to possibility that there may exist some links between the LAA subtype of stroke and elevated oxLDL (apoB100 aldehyde-modified form).
Vibo
Riina
R
Department of Neurology and Neurosurgery, University of Tartu, Estonia. riina.vibo@kliinikum.ee
Kõrv
Janika
J
Roose
Mai
M
Kampus
Priit
P
Muda
Piibe
P
Zilmer
Kersti
K
Zilmer
Mihkel
M
D000209:Acute-Phase Proteins / Q000032:analysis*; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D001921:Brain / Q000098:blood supply; D002545:Brain Ischemia / Q000175:diagnosis* / Q000209:etiology; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D002537:Intracranial Arteriosclerosis / Q000150:complications / Q000175:diagnosis*; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012307:Risk Factors; D012720:Severity of Illness Index; D020521:Stroke / Q000175:diagnosis* / Q000209:etiology; D014280:Triglycerides / Q000097:blood
D000209:Acute-Phase Proteins; D015415:Biomarkers; D001786:Blood Glucose; D008077:Lipoproteins, LDL; D014280:Triglycerides; C099252:oxidized low density lipoprotein