Improving biocompatibility of heart valve and vascular transplants by their devitalization and repopulation by recipient cells.
Inoculation of cells derived from the aorta of Wistar rats on devitalized porcine aortic walls 2-4-fold reduced their calcinosis after subcutaneous implantation to Wistar rats. Inoculation of Wistar rat bone marrow mesenchymal cells selected by adhesion activity did not reduce tissue calcinosis. The results indicate good prospects of repopulation of devitalized heart valve and vessel transplants by recipient vascular cells for reducing transplant calcinosis and improvement of their biocompatibility.
Akatov
V S
VS
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino. v-akatoff@rambler.ru
Ryndina
N I
NI
Solovyov
V V
VV
Muratov
R M
RM
Britikov
D V
DV
Bokeriya
L A
LA
D000818:Animals; D001011:Aorta / Q000166:cytology* / Q000648:ultrastructure; D001672:Biocompatible Materials; D002114:Calcinosis / Q000517:prevention & control*; D002118:Calcium / Q000032:analysis; D009202:Cardiomyopathies / Q000517:prevention & control*; D016022:Case-Control Studies; D002448:Cell Adhesion / Q000502:physiology*; D006351:Heart Valves / Q000637:transplantation*; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation; D008855:Microscopy, Electron, Scanning; D008856:Microscopy, Fluorescence; D032389:Myocytes, Smooth Muscle / Q000637:transplantation*; D051381:Rats; D017208:Rats, Wistar; D013054:Spectrophotometry, Atomic; D034421:Sus scrofa; D014183:Transplantation, Heterologous
D001672:Biocompatible Materials; D002118:Calcium