ETS transcription factors in endocrine systems.
E26 transformation-specific (ETS) transcription factors have become increasingly recognized as key regulators of differentiation, hormone responses and tumorigenesis in endocrine organs and target tissues. The ETS family is highly diverse, consisting of both transcription activators and repressors that mediate growth factor signaling and regulate gene expression through combinatorial interactions with multiple protein partners on composite DNA elements. ETS proteins have a role in the endocrine system in establishing pituitary-specific gene expression, mammary gland development and cancers of the breast, prostate and reproductive organs.
Gutierrez-Hartmann
Arthur
A
University of Colorado HSC, P. O. Box 6511, Mail Stop 8106, Aurora, CO 80045, USA. a.gutierrez-hartmann@UCHSC.edu
Duval
Dawn L
DL
Bradford
Andrew P
AP
D000818:Animals; D001943:Breast Neoplasms / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D042361:Mammary Glands, Human / Q000378:metabolism; D008958:Models, Molecular; D010190:Pancreatic Neoplasms / Q000378:metabolism; D010902:Pituitary Gland / Q000378:metabolism*; D011467:Prostate / Q000378:metabolism; D050783:Proto-Oncogene Proteins c-ets / Q000235:genetics / Q000378:metabolism*; D012098:Reproduction; D013964:Thyroid Neoplasms / Q000378:metabolism
D050783:Proto-Oncogene Proteins c-ets