title: Valvular heart disease associated with fenfluramine detected 7 years after discontinuation of treatment.
abstract: We report the case of a patient referred to us for mitral and aortic valvular disease with a rheumatic appearance. The unusual macroscopic appearance on valve resection was not compatible with a rheumatic cause. A detailed review of this patient's clinical history (ie, a history of treatment with fenfluramine) suggested an iatrogenic cause, which was confirmed by histology. For the first time, a case of valvular heart disease that deteriorated was discovered 7 years after treatment with fenfluramine, whereas this iatrogenic disease classically resolves after discontinuation of treatment. This case illustrates the need for continuing heart valve surveillance of patients who have used these anorectics.
authors: Department of Cardiothoracic Surgery, Louis Pradel Hospital, Lyon, France.
authors: Guillaume
authors: G
authors: Greffe
authors: Lara
authors: L
authors: Chalabreysse
authors: Carine
authors: C
authors: Mouly-Bertin
authors: Pierre
authors: P
authors: Lantelme
authors: Françoise
authors: F
authors: Thivolet
authors: Gilles
authors: G
authors: Aulagner
authors: Jean-François
authors: JF
authors: Obadia
mesh_terms: D000328:Adult; D001021:Aortic Valve / Q000473:pathology / Q000601:surgery; D001707:Biopsy, Needle; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D005277:Fenfluramine / Q000008:administration & dosage / Q000009:adverse effects*; D005500:Follow-Up Studies; D006349:Heart Valve Diseases / Q000139:chemically induced* / Q000601:surgery*; D019918:Heart Valve Prosthesis Implantation / Q000379:methods*; D006801:Humans; D007049:Iatrogenic Disease; D007150:Immunohistochemistry; D008943:Mitral Valve / Q000473:pathology / Q000601:surgery; D018570:Risk Assessment; D018490:Serotonin Agents / Q000008:administration & dosage / Q000009:adverse effects*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D018490:Serotonin Agents; D005277:Fenfluramine