title: Clinical manifestations due to severe plasminogen deficiency: a case report.
abstract: Plasminogen deficiency is a rare, destructive, and badly defined disorder. Recurrent and progressive gingival nodular hyperplasia with ulceration would appear to be an unreported complication caused by this deficiency. In some of the reported cases, gingival hyperplasia occurred in association with an eye disease called ligneous conjunctivitis. Including this case report, only 11 patients with proven functional plasminogen and oral lesions have been reported in the literature in English. The purpose of this paper was to present the case of a child patient with recurrent clinical manifestations caused by severe plasminogen deficiency who responded positively to corticosteroid treatment.
authors: Pediatric Hematology/Oncology Service, Araújo Jorge Cancer Hospital, Goiânia, Brazil.
authors: Geisa B L
authors: GB
authors: Silva
authors: César
authors: C
authors: Bariani
authors: Elismauro F
authors: EF
authors: Mendonça
authors: Aline C
authors: AC
authors: Batista
mesh_terms: D002386:Cataract / Q000209:etiology; D002648:Child; D003231:Conjunctivitis / Q000209:etiology; D005141:Eyelid Diseases / Q000209:etiology; D005500:Follow-Up Studies; D005882:Gingival Diseases / Q000209:etiology; D005885:Gingival Hyperplasia / Q000209:etiology*; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D019226:Oral Ulcer / Q000209:etiology; D010958:Plasminogen / Q000172:deficiency*; D011241:Prednisone / Q000627:therapeutic use
chemical_list: D005938:Glucocorticoids; D010958:Plasminogen; D011241:Prednisone; D008775:Methylprednisolone