title: Raised alanine transaminase and decreased adiponectin are features of the metabolic syndrome in patients with type 2 diabetes.
abstract: OBJECTIVE
  The aim of the study was to investigate the relationship between the metabolic syndrome (MS), adiponectin and abnormal liver enzymes in patients with type 2 diabetes.
  
  
  METHODS
  Fasting serum was collected from 189 patients with type 2 diabetes, adiponectin was measure using radioimmunoassay and features of the MS were assessed.
  
  
  RESULTS
  Mean ALT was significantly higher in patients with the MS and higher ALT was associated with lower adiponectin levels. As the number of features of MS increased, ALT increased and adiponectin decreased independent of glycaemic control.
  
  
  CONCLUSIONS
  Hypoadiponectinemia and the MS may be linked with liver injury in patients with type 2 diabetes.
authors: Centre for Diabetes and Endocrine Research, University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland, Australia. ihickman@cder.soms.uq.edu.au
authors: Ingrid J
authors: IJ
authors: Hickman
authors: Jonathan P
authors: JP
authors: Whitehead
authors: Johannes B
authors: JB
authors: Prins
authors: Graeme A
authors: GA
authors: Macdonald
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000410:Alanine Transaminase / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications / Q000188:drug therapy; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D008099:Liver / Q000201:enzymology; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000150:complications; D008875:Middle Aged; D012737:Sex Factors
chemical_list: D052242:Adiponectin; D000410:Alanine Transaminase; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents