Synthesis of para-methoxybenzyl (PMB) ethers under neutral conditions.
2-(4-Methoxybenzyloxy)-4-methylquinoline reacts with methyl triflate in the presence of alcohols to generate a neutral organic salt that transfers the para-methoxybenzyl (PMB) protecting group onto alcohols in high yield and under mild conditions.
Nwoye
Ernest O
EO
Department of Chemistry and Biochemistry, Florida State University, Tallahassee, FL, USA.
Dudley
Gregory B
GB