Isolation of constituents and anti-complement activity from Acer okamotoanum.
A novel acylated sterol glucoside (1) along with four known compounds, beta-amyrin acetate (2), 3beta,24-dihydroxytaraxer-14-ene (3), cleomiscosin A (4), and cleomiscosin C (5), were isolated from the leaf and twig of Acer okamotoanum Nakai (Aceraceae). The structure of the new compound was determined to be beta-sitosterol glucoside-3'-O-hexacosanoicate based on chemical and spectroscopic analyses. In addition, the novel compound was found to exhibit a significant inhibitory effect (IC50 value of 0.2 microM) on the complement system activated by the classical pathway.
Jin
WenYi
W
College of Pharmacy, Chungnam National University, Daejeon 305-764, Korea.
Min
Byung-Sun
BS
Lee
JongPill
J
Thuong
Phuong Thien
PT
Lee
Hyeong-Kyu
HK
Song
KyungSik
K
Seong
Yeon Hee
YH
Bae
KiHwan
K
D031002:Acer / Q000737:chemistry*; D051056:Complement Inactivating Agents / Q000302:isolation & purification / Q000494:pharmacology; D003171:Complement Pathway, Classical / Q000187:drug effects; D006801:Humans; D066298:In Vitro Techniques; D015394:Molecular Structure; D035261:Plant Components, Aerial / Q000737:chemistry; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology; D013329:Structure-Activity Relationship
D051056:Complement Inactivating Agents; D010936:Plant Extracts