Gene-drug interaction at the glucocorticoid receptor increases risk of squamous cell skin cancer.
Non-melanoma skin cancers (NMSCs) are the most common malignancy among US Caucasians. Using a population-based study of NMSC we found that oral steroid use is associated with nearly 6-fold elevated risk of squamous cell carcinoma among individuals with a common genetic variant in the steroid receptor (NR3C1) gene. Given the large numbers of individuals on immunosuppressive drug therapy for inflammatory disease, these findings have important implications for NMSC screening and prevention.
Patel
Anita S
AS
Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA.
Karagas
Margaret R
MR
Perry
Ann E
AE
Spencer
Steven K
SK
Nelson
Heather H
HH
D002294:Carcinoma, Squamous Cell / Q000209:etiology*; D016022:Case-Control Studies; D005938:Glucocorticoids / Q000009:adverse effects*; D006801:Humans; D010597:Pharmacogenetics; D011110:Polymorphism, Genetic; D011965:Receptors, Glucocorticoid / Q000235:genetics*; D012878:Skin Neoplasms / Q000209:etiology*
D005938:Glucocorticoids; C497713:NR3C1 protein, human; D011965:Receptors, Glucocorticoid