Olanzapine treatment decreases the density of muscarinic M2 receptors in the dorsal vagal complex of rats.
In this study, we investigated the effects of antipsychotic drugs, olanzapine and haloperidol, on the density of the muscarinic M2 receptors in the dorsal vagal complex (DVC) and hypoglossal nucleus (HN). Female Sprague Dawley rats were treated with olanzapine, haloperidol or vehicle (control) for 1 (short-term) or 12 weeks (long-term). Quantitative autoradiography was used to investigate the M2 receptor density in the DVC and HN using a muscarinic antagonist [(3)H] AF-DX384. Olanzapine, but not haloperidol, treatment induced a significant decrease in the binding density of M2 receptors in the DVC compared to control groups. Although the HN showed a higher density of [(3)H] AF-DX384 binding than the DVC, treatment with both olanzapine and haloperidol did not induce any significant changes in [(3)H] AF-DX384 binding in the HN. These results suggest that olanzapine-induced body weight gain may be associated with functional changes in the muscarinic neurotransmission in the DVC.
Deng
Chao
C
School of Health Sciences, University of Wollongong, NSW, Wollongong, Australia. chao@uow.edu.au
Weston-Green
Katrina L
KL
Han
Mei
M
Huang
Xu-Feng
XF
D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D001345:Autoradiography / Q000379:methods; D001569:Benzodiazepines / Q000494:pharmacology; D001667:Binding, Competitive / Q000187:drug effects; D005260:Female; D005786:Gene Expression Regulation / Q000187:drug effects*; D008526:Medulla Oblongata / Q000187:drug effects*; D000077152:Olanzapine; D010276:Parasympatholytics / Q000493:pharmacokinetics; D010890:Pirenzepine / Q000031:analogs & derivatives / Q000493:pharmacokinetics; D051381:Rats; D017207:Rats, Sprague-Dawley; D043585:Receptor, Muscarinic M2 / Q000378:metabolism*; D014316:Tritium / Q000493:pharmacokinetics; D015430:Weight Gain / Q000187:drug effects
D014150:Antipsychotic Agents; D010276:Parasympatholytics; D043585:Receptor, Muscarinic M2; D014316:Tritium; C065959:AFDX 384; D001569:Benzodiazepines; D010890:Pirenzepine; D000077152:Olanzapine