Comparison of Delta FVC (% decrease in FVC at the PC(20)) between cough-variant asthma and classic asthma.
The percentage decrease in forced vital capacity (FVC) at the methacholine PC(20) (Delta FVC) has been proposed as a surrogate marker of maximal airway response. The aim of this study was to compare the Delta FVC between patients with cough-variant asthma (CVA) and those with classic asthma (CA). We performed a retrospective analysis of methacholine challenge test data from 47 children who were diagnosed as having CVA and from 75 children who had CA of mild severity. The mean (+/- SD) Delta FVC was significantly (p = 0.001) lower in the CVA group (14.7 +/- 3.4%) compared with the CA group (17.1 +/- 4.4%), whereas PC(20) was not different between the two groups. Our results suggest that CVA is associated with a lower level of maximal airway response than CA.
Yoo
Young
Y
Department of Pediatrics, Korea University Anam Hospital, Seoul, Korea.
Yu
Jinho
J
Lee
Sun Hee
SH
Kim
Do Kyun
DK
Choi
Sun Hee
SH
Kim
Chang Keun
CK
Koh
Young Yull
YY
D001249:Asthma / Q000145:classification* / Q000503:physiopathology*; D001985:Bronchial Provocation Tests; D016085:Bronchoconstrictor Agents; D002648:Child; D003371:Cough / Q000145:classification* / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D016210:Methacholine Chloride; D012189:Retrospective Studies; D014797:Vital Capacity
D016085:Bronchoconstrictor Agents; D016210:Methacholine Chloride