Body iron is a contributor to oxidative damage of DNA.
The transition metal iron is catalytically highly active in vitro, and not surprisingly, body iron has been suggested to promote oxidative stress in vivo. In the current analysis we studied the association of serum ferritin concentration and serum soluble transferrin receptor concentration with daily urinary 8-hydroxydeoxyguanosine excretion, a marker of oxidative stress, in 48 mildly dyslipidemic men in East Finland. In multivariate linear regression analyses allowing for age, smoking, body mass index and physical exercise, serum ferritin concentration predicted the excretion rate at B = 0.17 (95% CI 0.08-0.26, P = 0.001), and serum soluble transferrin receptor to ferritin concentration ratio (TfR/ferritin) predicted the excretion rate at B = - 0.13 (95% CI - 0.21 to - 0.05, P = 0.002). Our data suggest that body iron contributes to excess oxidative stress already at non-iron overload concentrations in these subjects.
Tuomainen
Tomi-Pekka
TP
Research Institute of Public Health, School of Public Health and Clinical Nutrition, University of Kuopio, Finland.
Loft
Steffen
S
Nyyssönen
Kristiina
K
Punnonen
Kari
K
Salonen
Jukka T
JT
Poulsen
Henrik E
HE
D000080242:8-Hydroxy-2'-Deoxyguanosine; D001823:Body Composition; D004247:DNA / Q000378:metabolism; D004249:DNA Damage; D003849:Deoxyguanosine / Q000031:analogs & derivatives / Q000652:urine; D005260:Female; D005293:Ferritins / Q000097:blood*; D006801:Humans; D006937:Hypercholesterolemia / Q000378:metabolism*; D007501:Iron / Q000032:analysis / Q000097:blood*; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D011990:Receptors, Transferrin / Q000097:blood*; D014018:Tissue Distribution
D011990:Receptors, Transferrin; D000080242:8-Hydroxy-2'-Deoxyguanosine; D004247:DNA; D005293:Ferritins; D007501:Iron; D003849:Deoxyguanosine