title: Transition metal-catalyzed orthogonal solid-phase decoration of the 2(1H)-pyrazinone scaffold using a sulfur linker.
abstract: A new transition metal-catalyzed orthogonal solid-phase protocol for the synthesis of highly substituted 2(1H)-pyrazinones was developed, on the basis of Chan-Lam arylation and Liebeskind-Srogl cross-coupling reactions. This strategy opens the way for the generation of small libraries of 2(1H)-pyrazinone analogues for biological screening.
authors: Laboratory for Organic & Microwave-Assisted Chemistry, Department of Chemistry, University of Leuven, Celestijnenlaan 200F, B-3001 Leuven, Belgium.
authors: Nadya
authors: N
authors: Kaval
authors: Brajendra Kumar
authors: BK
authors: Singh
authors: Denis S
authors: DS
authors: Ermolat'ev
authors: Stijn
authors: S
authors: Claerhout
authors: Virinder S
authors: VS
authors: Parmar
authors: Johan Van
authors: JV
authors: der Eycken
authors: Erik Van
authors: EV
authors: der Eycken
mesh_terms: D002384:Catalysis; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D015394:Molecular Structure; D011719:Pyrazines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D013438:Sulfhydryl Compounds / Q000737:chemistry*; D028561:Transition Elements / Q000737:chemistry*
chemical_list: D011719:Pyrazines; D013438:Sulfhydryl Compounds; D028561:Transition Elements