Mebendazole selective membrane sensor and its application to pharmaceutical analysis.
A PVC membrane sensor for the selective determination of mebendazole (MBZ) was fabricated. The sensor is based on an ion association of MBZ with silicotungstic acid (STA) as ion pair and bis(2-ethylhexyl)phthalate (BEP) as the plasticizing agent in a PVC matrix. The sensor showed a linear response for MBZ for a concentration range 1.0x10(-6)-5.0x10(-2) M with a Nernstian slope of 55.8 mV/decade (limit of detection 6.3x10(-7) M) in the pH range 4-7. It has a fast response time of <30 s. The sensor showed a very good selectivity for MBZ with respect to a large number of ions. The direct determination of MBZ in pharmaceutical formulations gave results that compare well with the data obtained from the standard method.
Kumar
K Girish
KG
Department of Applied Chemistry, Cochin University of Science and Technology, Kochi, India. giri@cusat.ac.in
John
Sareena
S
Augustine
Pearl
P
Poduval
Remalakshmy
R
Saraswathyamma
Beena
B
D000871:Anthelmintics / Q000032:analysis; D006863:Hydrogen-Ion Concentration; D008463:Mebendazole / Q000737:chemistry*; D008567:Membranes, Artificial; D004364:Pharmaceutical Preparations / Q000032:analysis*; D011143:Polyvinyl Chloride / Q000737:chemistry; D017640:Silicates / Q000737:chemistry; D013997:Time Factors; D017973:Tungsten Compounds / Q000737:chemistry
D000871:Anthelmintics; D008567:Membranes, Artificial; D004364:Pharmaceutical Preparations; D017640:Silicates; D017973:Tungsten Compounds; D008463:Mebendazole; D011143:Polyvinyl Chloride; C021746:silicotungstic acid