title: Ciprofloxacin penetration into the pulmonary parenchyma in Japanese patients.
abstract: OBJECTIVE
  To assess the degree of penetration of intravenous (i.v.) ciprofloxacin into the lung parenchyma resected for lung carcinoma in Japanese patients.
  
  
  METHODS
  Ciprofloxacin was given i.v. over 1 h to ten Japanese patients with non-small cell lung carcinoma. We took 1 g of normal lung parenchyma and 1 ml of blood serum for analysis when the lung was resected. Ciprofloxacin concentrations were determined by high-performance liquid chromatography.
  
  
  RESULTS
  The mean time from the end of ciprofloxacin administration to lung resection was 135 +/- 55 min (range, 75-223 min). The mean concentrations of ciprofloxacin in the lung parenchyma and blood serum were 4.9 +/- 2.0 microg/g (range, 2.1-7.9) and 1.5 +/- 0.7 microg/ml (range, 0.8-2.7). The mean tissue per serum concentration ratio was 3.6 +/- 2.2 (range, 1.9-8.7).
  
  
  CONCLUSIONS
  The concentrations of ciprofloxacin in the lung parenchyma after i.v. administration in Japanese patients were above the minimal inhibitory concentration for bacteria from at least 75 min until 4 h later.
authors: Department of Surgery, Nippon Medical School Musashikosugi Hospital, 1-396 Kosugi-cho, Nakahara-ku, Kawasaki, Kanagawa, 211-8533, Japan.
authors: Shuji
authors: S
authors: Haraguchi
authors: Masafumi
authors: M
authors: Hioki
authors: Koji
authors: K
authors: Yamashita
authors: Koan
authors: K
authors: Orii
authors: Yasuo
authors: Y
authors: Yamashita
authors: Jun
authors: J
authors: Kawamura
authors: Mina
authors: M
authors: Takushima
authors: Naoya
authors: N
authors: Endo
authors: Kiyoshi
authors: K
authors: Koizumi
authors: Kazuo
authors: K
authors: Shimizu
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D002289:Carcinoma, Non-Small-Cell Lung / Q000601:surgery*; D002851:Chromatography, High Pressure Liquid; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D007564:Japan; D008168:Lung / Q000378:metabolism*; D008175:Lung Neoplasms / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000517:prevention & control*; D016896:Treatment Outcome
chemical_list: D000890:Anti-Infective Agents; D002939:Ciprofloxacin