title: Impaired glucose tolerance in first-episode drug-naïve patients with schizophrenia.
abstract: OBJECTIVE
  To determine whether there is an association between Type 2 diabetes mellitus and schizophrenia, independent of medication.
  
  
  METHODS
  In this cross-sectional study we performed an oral glucose tolerance test on 38 non-obese white Caucasians who fulfilled the criteria for first-episode drug-naïve schizophrenia, 38 control subjects (matched for age, gender, smoking status, alcohol intake and ethnicity) and 44 first-degree relatives of the patients.
  
  
  RESULTS
  The frequency of impaired glucose tolerance (IGT), defined by World Health Organization criteria, was 10.5% (n = 4) in patients with schizophrenia, 18.2% (n = 8) in unaffected relatives and 0.0% in healthy control subjects (chi(2) = 4.22, d.f. = 2, P < 0.05).
  
  
  CONCLUSIONS
  The high point prevalence of IGT in never-treated patients and relatives supports either shared environmental or genetic predisposition to IGT. Both patients and their relatives present an ideal cost-effective opportunity to screen for Type 2 diabetes mellitus, as they are both easily identifiable.
authors: Neuroscience Centre, St Vincent's Hospital, Dublin, Ireland.
authors: L M
authors: LM
authors: Spelman
authors: P I
authors: PI
authors: Walsh
authors: N
authors: N
authors: Sharifi
authors: P
authors: P
authors: Collins
authors: J H
authors: JH
authors: Thakore
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000032:analysis*; D003430:Cross-Sectional Studies; D005260:Female; D018149:Glucose Intolerance / Q000097:blood*; D005951:Glucose Tolerance Test; D006801:Humans; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000097:blood*
chemical_list: D001786:Blood Glucose