Reactivation of Snail genes in renal fibrosis and carcinomas: a process of reversed embryogenesis?
While the activity of Snail genes is required during embryonic development for the formation of different tissues and organs, they must be repressed in the adult in order to maintain epithelial integrity and homeostasis. Indeed, pathological activation of Snail in epithelial tumors induces malignancy and the recurrence of tumors. Here we show that in dedifferentiated areas of human renal carcinomas, Snail undergoes a process of reactivation. In addition to tumor progression, renal fibrosis is also linked to the activity of Snail genes and indeed, reactivation of Snail in the adult kidney is sufficient to induce fibrosis. Thus, Snail genes illustrate a paradigm whereby reactivation of crucial embryonic genes in adult tissues provokes the onset of devastating diseases.
Boutet
Agnès
A
Instituto de Neurociencias de Alicante, CSIC-UMH, Sant Joan d'Alacant, Spain.
Esteban
Miguel A
MA
Maxwell
Patrick H
PH
Nieto
M Angela
MA
D000818:Animals; D002277:Carcinoma / Q000196:embryology* / Q000235:genetics / Q000473:pathology; D047108:Embryonic Development / Q000235:genetics*; D005355:Fibrosis; D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology; D006801:Humans; D007668:Kidney / Q000196:embryology* / Q000378:metabolism / Q000473:pathology*; D007680:Kidney Neoplasms / Q000196:embryology* / Q000235:genetics / Q000473:pathology; D000071250:Snail Family Transcription Factors; D014157:Transcription Factors / Q000235:genetics* / Q000378:metabolism*
D000071250:Snail Family Transcription Factors; D014157:Transcription Factors