title: Allelic polymorphism in the Plasmodium vivax dihydrofolate reductase gene among Indian field isolates.
abstract: In total, 129 Plasmodium vivax isolates from different geographical areas in India were analysed for point mutations in the P. vivax dihydrofolate reductase gene that were associated with pyrimethamine resistance. A gradual increase in the frequency of mutant genotypes was observed from north to south (p <0.0001). In the northern region (Delhi, Panna and Nadiad), the wild-type genotype was most prevalent, while the mutant genotype predominated in the coastal regions of southern India (Navi Mumbai, Goa and Chennai). Isolates from the Car-Nicobar islands showed only mutant genotypes. The differential geographical pattern of mutations may be associated with the transmission pattern.
authors: National Institute of Malaria Research (ICMR), Delhi, India.
authors: S K
authors: SK
authors: Prajapati
authors: H
authors: H
authors: Joshi
authors: N
authors: N
authors: Valecha
authors: A M
authors: AM
authors: Reetha
authors: A
authors: A
authors: Eapen
authors: A
authors: A
authors: Kumar
authors: M K
authors: MK
authors: Das
authors: R S
authors: RS
authors: Yadav
authors: M A
authors: MA
authors: Rizvi
authors: A P
authors: AP
authors: Dash
mesh_terms: D000483:Alleles; D000818:Animals; D009154:Mutation; D010966:Plasmodium vivax / Q000201:enzymology* / Q000235:genetics; D011110:Polymorphism, Genetic; D013762:Tetrahydrofolate Dehydrogenase / Q000235:genetics*
chemical_list: D013762:Tetrahydrofolate Dehydrogenase