Inhibition of diamine oxidases and polyamine oxidases by diamine-based compounds.
This review reports on inhibitors of copper-containing amine oxidases and flavoprotein polyamine oxidases, which are structurally based on diamines. In the introduction, basic characteristics and classification of amine oxidases are described together with the significance of their synthetic inhibitors. The following text is divided into several chapters, which deal with diaminoketones, aza-diamines, unsaturated diamine analogs and diamines with heterocyclic substituents. Then it continues with diamine- and agmatine-based inhibitors of polyamine oxidases. Each chapter gives detailed information on the inhibition mode, potency and structural relationships. The conclusion points out possible roles of mechanism-based inhibitors of amine oxidases in physiological and medicinal research.
Sebela
M
M
Department of Biochemistry, Faculty of Science, Palacký University, Olomouc, Czech Republic.
Tylichová
M
M
Pec
P
P
D000376:Agmatine / Q000737:chemistry / Q000494:pharmacology; D006631:Amine Oxidase (Copper-Containing) / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D000818:Animals; D003959:Diamines / Q000737:chemistry / Q000494:pharmacology*; D004789:Enzyme Activation / Q000187:drug effects / Q000502:physiology; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D007659:Ketones / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure; D000587:Oxidoreductases Acting on CH-NH Group Donors / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D000097667:Polyamine Oxidase
D000376:Agmatine; D006631:Amine Oxidase (Copper-Containing); D003959:Diamines; D004791:Enzyme Inhibitors; D007659:Ketones; D000587:Oxidoreductases Acting on CH-NH Group Donors; D000097667:Polyamine Oxidase