Genetic analysis of MAPT haplotype diversity in frontotemporal dementia.
The H1 haplotype of the tau gene, MAPT, has been linked to the sporadic tauopathies corticobasal degeneration and progressive supranuclear palsy; however, there have been inconsistent findings regarding association with frontotemporal dementia (FTD). We investigated MAPT haplotype diversity, in 171 sporadic FTD and 186 healthy controls individuals, and report no single marker or haplotype association with increased risk or changes in age at onset. These findings do not support an association of MAPT with FTD but do not rule out its association with other tauopathies.
Laws
S M
SM
Neurochemistry and Neurogenetics Laboratory, Department of Psychiatry and Psychotherapy, Technische Universität München (TU-München), Ismaningerstr. 22, D-81675 München, Germany.
Friedrich
P
P
Diehl-Schmid
J
J
Müller
J
J
Ibach
B
B
Bäuml
J
J
Eisele
T
T
Förstl
H
H
Kurz
A
A
Riemenschneider
M
M
D003704:Dementia / Q000453:epidemiology* / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics; D014644:Genetic Variation / Q000235:genetics*; D005858:Germany / Q000453:epidemiology; D006239:Haplotypes; D006801:Humans; D015994:Incidence; D008297:Male; D015995:Prevalence; D016875:tau Proteins / Q000235:genetics*
C054369:MAPT protein, human; D016875:tau Proteins