Small noncoding RNAs controlling pathogenesis.
Infectious diseases are a leading cause of mortality worldwide. A major challenge in achieving their eradication is a better understanding of bacterial pathogenesis processes. The recent discovery of small noncoding RNAs (sRNAs) as modulators of gene expression in response to environmental cues has brought a new insight into bacterial regulation. sRNAs coordinate complex networks of stress adaptation and virulence gene expression. sRNAs generally ensure such a regulation by pairing to mRNAs of effector and/or regulatory genes, or by binding to proteins. An updated view on bacterial models responsible for important infections illustrates the key role of sRNAs in the control of pathogenesis.
Toledo-Arana
Alejandro
A
Institut Pasteur, Unité des Interactions Bactéries-Cellules, INSERM, U604, and INRA, USC2020, Paris, F-75015, France.
Repoila
Francis
F
Cossart
Pascale
P
D001419:Bacteria / Q000235:genetics* / Q000472:pathogenicity*; D015964:Gene Expression Regulation, Bacterial; D016680:Genome, Bacterial; D035001:Host Factor 1 Protein / Q000378:metabolism; D012329:RNA, Bacterial / Q000378:metabolism*; D022661:RNA, Untranslated / Q000378:metabolism*; D014774:Virulence / Q000235:genetics
D035001:Host Factor 1 Protein; D012329:RNA, Bacterial; D022661:RNA, Untranslated