title: [Diabetic ketoacidosis responsive to methotrexate in a patient with a mixed connective tissue disease].
abstract: We report a 42 year-old woman with a hypothyroidism and a mixed connective tissue disease treated with prednisone and methotrexate. The patient had normal blood glucose levels but when the methotrexate dose was tapered, she presented a diabetic ketoacidosis that required up to 520 units of insulin per day. Due to the intensification of the mixed connective tissue disease symptoms, the doses of methotrexate and prednisone were increased again with a simultaneous normalization of serum glucose levels and glucose tolerance. In the following six months, when the dose of methotrexate was tapered again, the hyperglycemia reappeared and was again controlled increasing the dose. Thirty months after the episode of ketoacidosis, the patient was with a weekly dose of methotrexate, asymptomatic and with a normal glucose tolerance. Anti insulin antibodies were not detected and anti islet antibodies were indeterminate, due to interference with antinuclear antibodies. It is possible that the episode of ketoacidosis was unveiled by an autoimmune phenomenon.
authors: Cátedra de Medicina, Facultad de Medicina, Universidad de Valparaíso, Viña del Mar Alto, Chile. victorianovik@gmail.com
authors: Victoria
authors: V
authors: Novik A
authors: Jorge
authors: J
authors: Vega S
authors: Verónica
authors: V
authors: Carreño P
authors: Macarena
authors: M
authors: Lagos G
mesh_terms: D000328:Adult; D001786:Blood Glucose; D016883:Diabetic Ketoacidosis / Q000139:chemically induced / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage; D007037:Hypothyroidism / Q000188:drug therapy; D007166:Immunosuppressive Agents / Q000008:administration & dosage* / Q000009:adverse effects; D007328:Insulin / Q000008:administration & dosage; D007333:Insulin Resistance / Q000502:physiology*; D008727:Methotrexate / Q000008:administration & dosage* / Q000009:adverse effects; D008947:Mixed Connective Tissue Disease / Q000188:drug therapy*; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy / Q000209:etiology
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007166:Immunosuppressive Agents; D007328:Insulin; D008727:Methotrexate