title: [A pilot study on relationship of periodontal status, serum level of interleukin-1beta and delivery outcomes in pregnant women].
abstract: OBJECTIVE
  To evaluate the associations between periodontal conditions, serum level of interleukin-1beta (IL-1beta) and delivery outcomes in pregnant women with a diagnosis of threatened premature labor(TPL).
  
  
  METHODS
  Eighty systemically healthy pregnant women were enrolled in the study. The case group was composed of 40 pregnant women hospitalized with the diagnosis of TPL (TPL group) and the control group was composed of 40 normal pregnant women (Non-TPL group). Periodontal examinations included assessments of plaque index (PLI), clinical attachment loss (CAL), probing depth (PD), bleeding index (BI) and the percent of periodontitis sites (PD >3 mm, CAL > or =2 mm). The serum level of IL-1beta was determined using commercially available enzyme-linked immunoassays.
  
  
  RESULTS
  (1) Fourteen of forty subjects of TPL group delivered premature labor infants (TPL-TB group), and twenty-six subjects delivered natural labor infants (TPL-PB group). No infants were delivered as premature labor infants in non-TPL group. There were significant differences in gestational age at delivery, birth weight, PLI, percentage of periodontitis sites and IL-1beta levels between the non-TPL group and TPL group or between the TPL-TB group and TPL-PB group (P < 0.05). (Significant negative correlation were observed between the gestational age at delivery and percentage of periodontitis sites as well as serum IL-1beta levels (P < 0.05). And significant positive correlation were observed between percentage of periodontitis site and serum IL-1beta levels (P < 0.05).
  
  
  CONCLUSIONS
  Periodontal inflammation might be one of the pathogenesis of preterm birth.
authors: Dept. of Oral Medicine, Zhejiang University School of Stomatology, Hangzhou 310006, China.
authors: Xiao-jun
authors: XJ
authors: Li
authors: Jing-jia
authors: JJ
authors: Kong
authors: Feng-bing
authors: FB
authors: Liang
authors: Hui
authors: H
authors: Chen
authors: Jing
authors: J
authors: He
mesh_terms: D000328:Adult; D003774:Dental Plaque Index; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D053583:Interleukin-1beta; D010518:Periodontitis; D010865:Pilot Projects; D011247:Pregnancy; D047928:Premature Birth
chemical_list: D053583:Interleukin-1beta