The constrained amino acid beta-Acc confers potency and selectivity to integrin ligands.
Urman
Sylwia
S
Fakultät für Chemie, Organische und Bioorganische Chemie, Universität Bielefeld, Universitätsstrasse 25, 33615 Bielefeld, Germany.
Gaus
Katharina
K
Yang
Yi
Y
Strijowski
Ulf
U
Sewald
Norbert
N
De Pol
Silvia
S
Reiser
Oliver
O
D002264:Carboxylic Acids / Q000737:chemistry*; D002448:Cell Adhesion / Q000187:drug effects; D002460:Cell Line; D003521:Cyclopropanes / Q000737:chemistry*; D006801:Humans; D039302:Integrin alphaVbeta3 / Q000737:chemistry*; D020014:K562 Cells; D008024:Ligands; D008968:Molecular Conformation; D009842:Oligopeptides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D002264:Carboxylic Acids; D003521:Cyclopropanes; D039302:Integrin alphaVbeta3; D008024:Ligands; D009842:Oligopeptides; C521993:cis-beta-aminocyclopropanecarboxylic acid