Early prediction of anthracycline induced cardiotoxicity.
OBJECTIVE
The purpose of this study is to evaluate echocardiographically determined cardiac functions with serum levels of brain natriuretic peptide (BNP), cardiac troponin I (cTnI) and total antioxidant status (TAOS) in childhood leukemia treated with chemotherapeutics containing anthracyclines.


METHODS
A study group of 29 patients who have been followed for acute lymphoblastic leukemia (ALL) and administered a treatment protocol containing chemotherapy of anthracyclines were included in the analysis. Levels of BNP, cTnI and TAOS were studied in serum samples of the patients.


RESULTS
We demonstrated that as the drug dosage increased, systolic ejection fraction (EF) and shortening fraction (FS) values decreased (EF r2=0.2327, FS r2=0.251). On the other hand, increased dosage of anthracycline therapy was associated with significant raise in plasma BNP levels (r2=0.246) and significant decrease in serum TAOS levels (r2=0.317) without any change in serum cTnI levels.


CONCLUSIONS
Our study suggest that serum TAOS and BNP levels may be useful as an early and sensitive indicator of anthracycline induced cardiotoxicity.
Erkus
Bedirhan
B
Department of Biochemistry, Faculty of Medicine, Ankara University, Turkey.
Demirtas
Selda
S
Yarpuzlu
Aysegul Akbay
AA
Can
Murat
M
Genc
Yasemin
Y
Karaca
Levent
L
D018943:Anthracyclines / Q000008:administration & dosage / Q000009:adverse effects*; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects*; D000975:Antioxidants / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D064420:Drug-Related Side Effects and Adverse Reactions / Q000097:blood* / Q000000981:diagnostic imaging / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D020097:Natriuretic Peptide, Brain / Q000097:blood; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D011237:Predictive Value of Tests; D013318:Stroke Volume / Q000187:drug effects / Q000502:physiology; D019210:Troponin I / Q000097:blood; D014463:Ultrasonography
D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic; D000975:Antioxidants; D019210:Troponin I; D020097:Natriuretic Peptide, Brain