title: Discrimination of Brugada syndrome patients from individuals with the saddle-back type ST-segment elevation using a marker of the standard 12-lead electrocardiography.
abstract: BACKGROUND
  In the clinical situation, the saddle-back (S-B) type is more frequently detected than the coved type. In the present study, the discrimination of Brugada syndrome from the S-B type individuals using a marker of the standard 12-lead electrocardiography (ECG) was attempted.
  
  
  RESULTS
  The study group consisted of 55 individuals with the S-B type in whom pilsicainide provocation test (PLC test) was carried out. The time from the onset of the QRS wave in lead V(2) (IV (2)) to the peak of the late R-like wave in the QRS wave (PV(2)), and the time from IV(2) to the offset of the QRS wave in lead V(5) (EV(5)) were measured. The coved type was induced by the PLC test in 29 cases (N-C group), but not in the remaining 26 cases (N-N group). The (IV(2) -PV(2)) - (IV(2) - EV(5)) value before the PLS test was greater in the N-C group than in the N-N group. The negative predictive value of ;(IV(2) - PV(2)) - (IV(2) - EV(5)) > or =0' was 76.4% for the prediction of a positive PLC test.
  
  
  CONCLUSIONS
  A ;(IV(2) - PV(2)) - (IV(2) - EV(5)) > or =0' is a useful ECG marker for the discrimination of Brugada syndrome in the S-B type individuals.
authors: Division of Cardiology, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan.
authors: Kiyoshi
authors: K
authors: Nakazawa
authors: Tsuneharu
authors: T
authors: Sakurai
authors: Ryoji
authors: R
authors: Kishi
authors: Akihiko
authors: A
authors: Takagi
authors: Keizo
authors: K
authors: Osada
authors: Shonosuke
authors: S
authors: Ryu
authors: Sadanori
authors: S
authors: Fujita
authors: Hisao
authors: H
authors: Matsuda
authors: Yukako
authors: Y
authors: Ishikawa
authors: Fumihiko
authors: F
authors: Miyake
mesh_terms: D000328:Adult; D000368:Aged; D001145:Arrhythmias, Cardiac / Q000175:diagnosis*; D015415:Biomarkers; D053840:Brugada Syndrome / Q000175:diagnosis* / Q000503:physiopathology*; D003937:Diagnosis, Differential; D004562:Electrocardiography / Q000187:drug effects; D005260:Female; D006801:Humans; D008012:Lidocaine / Q000031:analogs & derivatives; D008297:Male; D008875:Middle Aged; D026941:Sodium Channel Blockers
chemical_list: D015415:Biomarkers; D026941:Sodium Channel Blockers; D008012:Lidocaine; C042288:pilsicainide