Targeting ROS: selective killing of cancer cells by a cruciferous vegetable derived pro-oxidant compound.
Oncogenic transformation usually leads to increase of cellular reactive oxygen species (ROS) level that renders the cells vulnerable to additional ROS production. By targeting ROS, a naturally occurring ROS-inducing compound, beta-phenylethyl isothiocyanate (PEITC), selectively kills the transformed cells but not normal cells.
Wu
Xin-jiang
XJ
Abramson Family Cancer Research Institute, Department of Cancer Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.
Hua
Xianxin
X
D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D019607:Brassicaceae / Q000737:chemistry; D002471:Cell Transformation, Neoplastic / Q000187:drug effects; D016044:Fusion Proteins, bcr-abl / Q000378:metabolism; D006801:Humans; D017879:Isothiocyanates / Q000494:pharmacology*; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology*; D015689:Oncogene Protein p21(ras) / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism*
D016588:Anticarcinogenic Agents; D017879:Isothiocyanates; D017382:Reactive Oxygen Species; C058305:phenethyl isothiocyanate; D016044:Fusion Proteins, bcr-abl; D015689:Oncogene Protein p21(ras)