[Ileo pouch-anal anastomosis].
Restorative proctocolectomy with an ileal pouch-anal anastomosis is the treatment of choice in patients with ulcerative colitis (UC) and familial adenomatous polyposis requiring surgical therapy. Pouchitis is the most frequent complication, occurring in up to 50% of patients with underlying UC. Clinical symptoms of the disease are non-specific. Moreover, surgical complications must be differentiated from idiopathic pouchitis using pouchoscopy, endoscopic ultrasound or MRI of the pelvis in certain cases. The therapy for idiopathic pouchitis, its etiology and pathophysiology being unclear, is based on antibiotic treatment, usually with metronidazole or ciprofloxacin. Probiotics such as VSL#3 can be used to prevent relapse. In summary, the clinical and functional outcomes are excellent and stable for 20 years after surgery.
Stallmach
A
A
Abteilung für Gastroenterologie, Hepatologie und Infektiologie, Friedrich-Schiller-Universität, Erlanger Allee 101, 07740 Jena, Germany. andreas.stallmach@med.uni-jena.de
Schmidt
C
C
D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D039021:Colonic Pouches / Q000009:adverse effects*; D006801:Humans; D019449:Pouchitis / Q000209:etiology* / Q000517:prevention & control*; D019936:Probiotics / Q000008:administration & dosage*; D016737:Proctocolectomy, Restorative / Q000009:adverse effects*; D018570:Risk Assessment
D000900:Anti-Bacterial Agents