title: Early tumor regression following severe lung injury after allogeneic stem cell transplantation in a patient with renal cell carcinoma.
abstract: We describe a 65-year-old man who had repeated lung injuries after reduced-intensity allogeneic stem cell transplantation (RIST) for renal cell carcinoma. Severe pneumonitis developed twice at the time of neutrophil recovery and acute graft-versus-host disease. Both episodes were successfully treated with steroid pulse therapy. Metastases regressed after the first episode and were stable during these lung disorders, but he died of tumor progression 6 months after RIST. This case suggests that certain local inflammatory reactions may be associated with an anti-tumor effect.
authors: Department of Hematology and Oncology, Mie University School of Medicine, Mie.
authors: Natsuki
authors: N
authors: Hoshino
authors: Kazunori
authors: K
authors: Nakase
authors: Isao
authors: I
authors: Tawara
authors: Shinichi
authors: S
authors: Kageyama
authors: Kohshi
authors: K
authors: Ohishi
authors: Kazuhiro
authors: K
authors: Nishii
authors: Yoshiki
authors: Y
authors: Sugimura
authors: Hiroshi
authors: H
authors: Shiku
authors: Naoyuki
authors: N
authors: Katayama
mesh_terms: D000368:Aged; D002292:Carcinoma, Renal Cell / Q000473:pathology / Q000628:therapy*; D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology / Q000628:therapy*; D008297:Male; D011859:Radiography; D012074:Remission Induction; D012128:Respiratory Distress Syndrome / Q000000981:diagnostic imaging / Q000209:etiology* / Q000628:therapy; D033581:Stem Cell Transplantation / Q000009:adverse effects*; D013899:Thoracic Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary / Q000628:therapy; D016896:Treatment Outcome