title: Hyrtinadine A, a bis-indole alkaloid from a marine sponge.
abstract: A new cytotoxic bis-indole alkaloid, hyrtinadine A (1), with a pyrimidine moiety has been isolated from an Okinawan marine sponge Hyrtios sp., and the structure was elucidated on the basis of spectroscopic data.
authors: Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.
authors: Taeko
authors: T
authors: Endo
authors: Masashi
authors: M
authors: Tsuda
authors: Jane
authors: J
authors: Fromont
authors: Jun'ichi
authors: J
authors: Kobayashi
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D007624:KB Cells; D008386:Marine Biology; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D026121:Indole Alkaloids; C519139:hyrtinadine A