Triggering antiviral response by RIG-I-related RNA helicases.
TLRs detect several classes of virus-associated molecules, such as ssRNA, CpG-DNA and dsRNA, and transduce signals leading to the production of IFN. Recently discovered cytoplasmic RNA helicases, RIG-I and MDA5, selectively sense viral RNA species. Gene disruption studies revealed the critical but non-redundant function of RIG-I and MDA5 in host antiviral responses.
Fujita
Takashi
T
Laboratory of Molecular Genetics, Institute for Virus Research, Kyoto University, Kyoto 606-8507, Japan. tfujita@virus.kyoto-u.ac.jp
Onoguchi
Kazuhide
K
Onomoto
Koji
K
Hirai
Reiko
R
Yoneyama
Mitsutoshi
M
D000818:Animals; D000998:Antiviral Agents / Q000627:therapeutic use*; D003593:Cytoplasm / Q000201:enzymology / Q000378:metabolism; D006801:Humans; D007113:Immunity, Innate; D008565:Membrane Proteins / Q000737:chemistry; D008954:Models, Biological; D009419:Nerve Tissue Proteins / Q000737:chemistry; D017434:Protein Structure, Tertiary; D020365:RNA Helicases / Q000737:chemistry*; D012330:RNA, Double-Stranded / Q000737:chemistry*; D012367:RNA, Viral / Q000737:chemistry; D011956:Receptors, Cell Surface; D015398:Signal Transduction; D051193:Toll-Like Receptors / Q000378:metabolism; D000097905:Roundabout Proteins
D000998:Antiviral Agents; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D020365:RNA Helicases; D012330:RNA, Double-Stranded; D012367:RNA, Viral; D011956:Receptors, Cell Surface; D051193:Toll-Like Receptors; C118348:Robo3 protein, mouse; D000097905:Roundabout Proteins