title: Monoclonal gammopathy of undetermined significance and smoldering multiple myeloma.
abstract: Monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM) are asymptomatic disorders characterized by monoclonal plasma cell proliferation in the bone marrow in the absence of end-organ damage. Updated diagnostic criteria for these disorders, risk-stratification models to determine prognosis, and the current management of these two entities are discussed in this review.
authors: Division of Hematology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, United States. rajkumar.vincent@mayo.edu
authors: S Vincent
authors: SV
authors: Rajkumar
authors: Martha Q
authors: MQ
authors: Lacy
authors: Robert A
authors: RA
authors: Kyle
mesh_terms: D018450:Disease Progression; D006801:Humans; D009101:Multiple Myeloma / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology; D009389:Neovascularization, Pathologic; D010265:Paraproteinemias / Q000097:blood / Q000175:diagnosis / Q000276:immunology / Q000503:physiopathology; D011379:Prognosis; D012307:Risk Factors