title: CD38 and CD157 as receptors of the immune system: a bridge between innate and adaptive immunity.
abstract: This paper reviews some of the results and the speculations presented at the Torino CD38 Meeting in June, 2006 and focused on CD38 and CD157 seen as a family of molecules acting as surface receptors of immune cells. This partisan view was adopted in the attempt to combine the enzymatic functions with what the immunologists consider key functions in different cell models. At the moment, it is unclear whether the two functions are correlated, indifferent, or independent. Here we present conclusions inferred exclusively on human cell models, namely T and B lymphocytes, dendritic cells, and granulocytes. As an extra analytical tool, we try to follow in the history of life when the enzymatic and receptorial functions were generated, mixing ontogeny, membrane localization, and cell anchorage.
authors: Laboratory of Immunogenetics, Department of Genetics, Biology and Biochemistry, University of Torino Medical School, Torino, Italy. fabio.malavasi@unito.it
authors: Fabio
authors: F
authors: Malavasi
authors: Silvia
authors: S
authors: Deaglio
authors: Enza
authors: E
authors: Ferrero
authors: Ada
authors: A
authors: Funaro
authors: Jaime
authors: J
authors: Sancho
authors: Clara M
authors: CM
authors: Ausiello
authors: Erika
authors: E
authors: Ortolan
authors: Tiziana
authors: T
authors: Vaisitti
authors: Mercedes
authors: M
authors: Zubiaur
authors: Giorgio
authors: G
authors: Fedele
authors: Semra
authors: S
authors: Aydin
authors: Elena V
authors: EV
authors: Tibaldi
authors: Ilaria
authors: I
authors: Durelli
authors: Riccardo
authors: R
authors: Lusso
authors: Franco
authors: F
authors: Cozno
authors: Alberto L
authors: AL
authors: Horenstein
mesh_terms: D036541:ADP-ribosyl Cyclase / Q000276:immunology*; D051997:ADP-ribosyl Cyclase 1 / Q000276:immunology*; D000818:Animals; D015703:Antigens, CD / Q000276:immunology*; D001048:Aplysia / Q000276:immunology; D002462:Cell Membrane / Q000276:immunology; D058851:GPI-Linked Proteins; D006801:Humans; D007113:Immunity, Innate
chemical_list: D015703:Antigens, CD; D058851:GPI-Linked Proteins; D036541:ADP-ribosyl Cyclase; C087521:ADP-ribosyl cyclase 2; D051997:ADP-ribosyl Cyclase 1