title: Bone marrow morphologic findings in patients with human immunodeficiency virus (HIV) infection.
abstract: The hematologic, histologic and morphologic bone marrow findings of 18 patients with human immunodeficiency virus (HIV) infection were reviewed. The mean age of the patients studied was 27 years; age range was six to 63 years. The main bone marrow morphologic finding was hypercellularity (72%), which was mainly due to megakaryocytic hyperplasia with or without granulocytic or erythrocytic hyperplasia. Naked (denuded) megakaryocytic nuclei, which are considered an indicator of HIV infection, were present in 72% of the bone marrows examined. Reticuloendothelial iron blockade was identified in 78% of cases. Other less frequent findings included erythrocytic dysplasia (44%), plasmacytosis (28%), nonspecific granulomas (17%), Hodgkin's and non-Hodgkin's lymphoma (17%), lymphocytic aggregates (11%) and histiocytosis (6%) . The bone marrow findings in this series of HIV patients appear to be similar to what has been previously reported from other countries.
authors: Departments of Pathology and Laboratory Medicine, Pediatrics and Medicine, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
authors: S H
authors: SH
authors: Khalil
authors: R M
authors: RM
authors: Nounou
authors: H
authors: H
authors: Frayha
authors: M A
authors: MA
authors: Halim
authors: M
authors: M
authors: Ellis
authors: F T
authors: FT
authors: Black