The genetics of aspirin resistance.
Aspirin is widely used for the prophylaxis of cardiovascular events in patients with cardiovascular risk factors or established atherosclerotic disease. However, despite aspirin treatment, a substantial number of patients experience recurrent events. Such 'aspirin resistance' is generally defined as failure of aspirin to produce an expected biological response, for example inhibition of platelet aggregation or of thromboxane A2 synthesis. Whilst its aetiology is multifactorial, genetic factors are also likely to play their part. Here we review the evidence for and against such a genetic contribution, as well as the data suggesting the involvement of specific genes.
Goodman
Timothy
T
Department of Clinical Pharmacology, Cardiovascular Division, King's College London, and Department of Clinical Neuroscience, Hammersmith Hospitals, London, UK. timothy.goodman@kcl.ac.uk
Sharma
Pankaj
P
Ferro
Albert
A
D001241:Aspirin / Q000627:therapeutic use*; D002318:Cardiovascular Diseases / Q000188:drug therapy / Q000235:genetics*; D004351:Drug Resistance / Q000235:genetics*; D005176:Factor XIII / Q000235:genetics; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006801:Humans; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000235:genetics; D011110:Polymorphism, Genetic / Q000235:genetics; D011451:Prostaglandin-Endoperoxide Synthases / Q000235:genetics* / Q000378:metabolism; D038981:Receptors, Collagen / Q000235:genetics; D018048:Receptors, Purinergic P2 / Q000235:genetics
D005343:Fibrinolytic Agents; D010975:Platelet Aggregation Inhibitors; D019039:Platelet Glycoprotein GPIIb-IIIa Complex; D038981:Receptors, Collagen; D018048:Receptors, Purinergic P2; D005176:Factor XIII; D011451:Prostaglandin-Endoperoxide Synthases; D001241:Aspirin