[Effects of mechanical ventilation on vascular endothelial function in patients with systemic inflammatory response syndrome].
OBJECTIVE
To study the effect of mechanical ventilation on vascular endothelial function in patients with systemic inflammatory response syndrome (SIRS).


METHODS
All patients showing SIRS were divided into two groups: mechanical ventilation (MV) group (n=35) and non-MV group (n=43). Nitric oxide (NO), angiotensin-conversion enzyme (ACE), endothelin-1 (ET-1), and circulating endothelial cells (CEC) of each patient were measured on the 1 st and 7 th day after admission.


RESULTS
Acute physiology and chronic health evaluation II (APACHE II) scores of MV group were significantly higher than those of non-MV group at different time points after admission (all P<0.01). There was significant correlation of APACHE II with each inflammatory mediator at each time point and the coefficients were similar. By analysis of covariance, NO and APACHE II score were negatively correlated, other indexes were positively correlated with APACHE II score. There were not significant variances in two groups on the 1 st hospital day (all P>0.05); but on the 7 th hospital day, the levels of ET-1, ACE and CEC were all increased, but NO decreased (all P<0.05). NO content and APACHE II score could forecast the prognosis with the conclusion of Logistic analysis.


CONCLUSIONS
There are very high correlations between the degree of vascular endothelial dysfunction and the seriousness of diseases in patients with SIRS. MV exerts significant damage to the vascular endothelial function in patients.
Wang
Shuo
S
Department of Emergency, Chaoyang Hospital, Capital University of Medical Science, Beijing 100020, China.
Li
Yi-xian
YX
Li
Chun-sheng
CS
D004730:Endothelium, Vascular / Q000503:physiopathology*; D006801:Humans; D012121:Respiration, Artificial; D018746:Systemic Inflammatory Response Syndrome / Q000503:physiopathology* / Q000628:therapy