Cytotoxic isoquinoline alkaloids from the aerial parts of Corydalis incisa.
Three known isoquinoline alkaloids were isolated from the chloroform-soluble fraction of the methanolic extract of the aerial parts of Corydalis incisa (Papaveraceae) through repeated column chromatography. Their chemical structures were elucidated as corynoline (1), corynoloxine (2) and 6-oxocorynoline (3) using spectroscopic analysis. Compounds 1-3 exhibited cytotoxicity against human A549, SK-OV-3, SK-MEL-2 and HCT15 tumor cells.
Choi
Sang Un
SU
College of Pharmacy, Woosuk University, Samrye 565-701, Korea.
Baek
Nam-In
NI
Kim
Sung-Hoon
SH
Yang
Jae Heon
JH
Eun
Jae Soon
JS
Shin
Tae Yong
TY
Lim
Jong Pil
JP
Lee
Jae Hyeok
JH
Jeon
Hoon
H
Yun
Mi-Young
MY
Leem
Kang-Hyun
KH
Park
Hee Wook
HW
Kim
Dae Keun
DK
D000470:Alkaloids / Q000302:isolation & purification / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology*; D002448:Cell Adhesion / Q000187:drug effects; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D031311:Corydalis / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007546:Isoquinolines / Q000302:isolation & purification / Q000494:pharmacology*; D015394:Molecular Structure; D009504:Neutrophils / Q000166:cytology; D035261:Plant Components, Aerial / Q000737:chemistry; D013329:Structure-Activity Relationship
D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D007546:Isoquinolines