Postoperative coagulopathy in a pediatric patient after exposure to bovine topical thrombin.
Severe postoperative coagulopathy developed in a child with congenital heart disease due to a factor V inhibitor from repetitive exposure to bovine topical thrombin. This case report alerts pediatric providers to consider these inhibitors when postoperative coagulopathy occurs. Potential treatment options are reviewed.
Crow
Sheri S
SS
Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota 55455, USA.
Sullivan
Vita V
VV
Aysola
Agnes E
AE
Key
Nigel S
NS
Harker-Murray
Paul
P
Foker
John E
JE
Steiner
Marie E
ME
D000287:Administration, Topical; D000818:Animals; D001778:Blood Coagulation Disorders / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy; D016063:Blood Loss, Surgical / Q000517:prevention & control; D001803:Blood Transfusion; D006348:Cardiac Surgical Procedures / Q000009:adverse effects / Q000379:methods; D002417:Cattle; D005165:Factor V / Q000032:analysis*; D005260:Female; D005500:Follow-Up Studies; D006330:Heart Defects, Congenital / Q000175:diagnosis / Q000601:surgery; D006489:Hemostatic Techniques / Q000009:adverse effects; D006801:Humans; D007136:Immunoglobulins / Q000627:therapeutic use; D007223:Infant; D011183:Postoperative Complications / Q000175:diagnosis / Q000628:therapy; D018633:Pulmonary Atresia / Q000175:diagnosis / Q000601:surgery*; D018570:Risk Assessment; D013917:Thrombin / Q000008:administration & dosage / Q000009:adverse effects*
D007136:Immunoglobulins; D005165:Factor V; D013917:Thrombin