SAR studies on thiazolo[4,5-d]pyrimidine based CXCR2 antagonists involving a novel tandem displacement reaction.
As part of a Lead Optimisation programme to identify small molecule antagonists of the human CXCR2 receptor, a series of substituted thiazolo[4,5-d]pyrimidines was prepared via the application of a novel tandem displacement reaction.
Hunt
Fraser
F
AstraZeneca R&D Charnwood, Bakewell Road, Loughborough LE11 5RH, UK. FRASER.HUNT@ASTRAZENECA.COM
Austin
Caroline
C
Austin
Rupert
R
Bonnert
Roger
R
Cage
Peter
P
Christie
Jadeen
J
Christie
Mark
M
Dixon
Clare
C
Hill
Steven
S
Jewell
Robert
R
Martin
Ian
I
Robinson
David
D
Willis
Paul
P
D000818:Animals; D006801:Humans; D051381:Rats; D018121:Receptors, Cytokine / Q000037:antagonists & inhibitors; D023063:Receptors, Interleukin-8B / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000737:chemistry / Q000494:pharmacology*
D018121:Receptors, Cytokine; D023063:Receptors, Interleukin-8B; D013844:Thiazoles; C039201:thiazolo(3,2-a)perimidine