Pseudoginsenoside-F11 decreases morphine-induced behavioral sensitization and extracellular glutamate levels in the medial prefrontal cortex in mice.
Morphine produces a variety of behavioral and biochemical changes related to its abuse. Our previous studies showed that Pseudoginsenoside-F11 (PF11), an ocotillol-type saponin existing in American ginseng, can antagonize pharmacological effects of morphine. To further investigate the effects of PF11 on morphine abuse and the underlying mechanisms, we tested the effects of PF11 on morphine-induced development of behavioral sensitization and alterations in glutamate levels in the medial prefrontal cortex (mPFC) in freely moving mice by using in vivo microdialysis. As the results shown, PF11 antagonized the development of behavioral sensitization and decrease of glutamate in the mPFC induced by morphine. Therefore, these findings suggest that PF11 may block the development of morphine-induced behavioral sensitization via its effect, at least partially, on the glutamatergic system in the mPFC.
Hao
Yue
Y
Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang 110016, P.R. China.
Yang
Jing Yu
JY
Wu
Chun Fu
CF
Wu
Min Fan
MF
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects* / Q000502:physiology; D045604:Extracellular Fluid / Q000378:metabolism; D036145:Ginsenosides / Q000494:pharmacology*; D018698:Glutamic Acid / Q000378:metabolism*; D008297:Male; D051379:Mice; D017551:Microdialysis; D009020:Morphine / Q000037:antagonists & inhibitors* / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D017397:Prefrontal Cortex / Q000033:anatomy & histology / Q000187:drug effects* / Q000502:physiology
D036145:Ginsenosides; C413985:pseudoginsenoside F11; D018698:Glutamic Acid; D009020:Morphine