title: High level of tumour protein p53-induced nuclear protein 1 (TP53INP1) expression in anaplastic carcinoma of the thyroid.
abstract: OBJECTIVE
  Tumour protein p53-induced nuclear protein 1 (TP531NP1) is a stress-induced protein and plays a role in cell cycle arrest and p53-mediated apoptosis. In this study, we investigated TP531NP1 expression in human thyroid neoplasms.
  
  
  METHODS
  We immunohistochemically investigated TP531NP1 in 197 cases of various thyroid neoplasms.
  
  
  RESULTS
  Normal follicles did not express TP531NP1. All 39 (20 minimally invasive and 19 widely invasive) follicular carcinomas and 20 adenomas were negative for or expressed only low levels of TP531NP1 except for one widely invasive follicular carcinoma. Of 100 papillary carcinomas, only four (4%) expressed high levels of TP531NP1, and the remaining 96 (96%) were classified into the low group. There were no significant relationships between TP531NP1 expression and clinicopathological features of papillary carcinoma. However, 36 of the 38 (94.7%) anaplastic carcinomas expressed high levels of TP531NP1 and the incidence was significantly higher (p<0.0001) than that in other neoplasms.
  
  
  CONCLUSIONS
  These findings suggest that TP531NP1 plays a significant role in the progression of anaplastic carcinoma or contributes to anaplastic transformation from papillary or follicular carcinoma, which is in sharp contrast to findings in previous in vitro and in vivo studies.
authors: Department of Surgery, Kuma Hospital, Kobe, Japan. ito01@kuma-h.or.jp
authors: Yasuhiro
authors: Y
authors: Ito
authors: Yoshiharu
authors: Y
authors: Motoo
authors: Hiroshi
authors: H
authors: Yoshida
authors: Juan Lucio
authors: JL
authors: Iovanna
authors: Yasushi
authors: Y
authors: Nakamura
authors: Kanji
authors: K
authors: Kuma
authors: Akira
authors: A
authors: Miyauchi
mesh_terms: D000236:Adenoma / Q000378:metabolism / Q000473:pathology; D002277:Carcinoma / Q000378:metabolism* / Q000473:pathology; D002291:Carcinoma, Papillary / Q000473:pathology; D018265:Carcinoma, Papillary, Follicular / Q000378:metabolism / Q000473:pathology; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism*; D015972:Gene Expression Regulation, Neoplastic; D006360:Heat-Shock Proteins / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D013964:Thyroid Neoplasms / Q000378:metabolism* / Q000473:pathology
chemical_list: D002352:Carrier Proteins; D006360:Heat-Shock Proteins; C429767:TP53INP1 protein, human