[The level of C-reactive protein and major artery elasticity in patients with ischemic heart disease].
OBJECTIVE
To assess elasticity of the major arteries in patients with ischemic heart disease (IHD) with reference to concentration of C-reactive protein (CRP).


METHODS
A total of 52 IHD males (mean age 54 +/- 1.58 years) with functional class I-III angina pectoris and heart failure entered the trial. Major artery elasticity was defined by velocity of the pulse wave. Response of the major arteries (a. radialis) to circulation intensification was evaluated with reactive hyperemia test. Concentration of CRP was determined by enzyme immunoassay.


RESULTS
There is a significant correlation between pulse wave velocity for elastic arteries and the levels of C-reactive protein (r = 0.34; p = 0.018). In investigation of endothelium-dependent reactivity we detected significant changes in the response of muscular-type artery to enhancement of blood flow. CRP concentration significantly correlated with pulse wave velocity inhibition in response to blood flow intensification (r = 0.49; p = 0.0005).


CONCLUSIONS
Elevation of C-reactive protein in blood plasma of IHD patients may point to marked changes in elasticity of major arteries. Simultaneous assessment of lipid spectrum and CRP enhances diagnostic significance of each index, separately.
Iliukhin
O V
OV
Iliukhina
M V
MV
Kalganova
E L
EL
Lopatin
Iu M
IuM
D015415:Biomarkers / Q000097:blood; D001783:Blood Flow Velocity / Q000502:physiology; D002097:C-Reactive Protein / Q000378:metabolism*; D004548:Elasticity; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood* / Q000503:physiopathology; D011379:Prognosis; D017534:Radial Artery / Q000503:physiopathology*; D014655:Vascular Resistance / Q000502:physiology*
D015415:Biomarkers; D002097:C-Reactive Protein