Intermolecular asymmetric reductive aldol reaction of ketones as acceptors promoted by chiral Rh(Phebox) catalyst.
[reaction: see text] The conjugate reduction of cinnamates with hydrosilane and chiral Rh(Phebox-ip) catalyst in the presence of excess acetone is shown to provide the corresponding intermolecular reductive aldol product in extremely high enantioselectivity (up to 98%). Several cinnamates and crotonate substrates and several ketone acceptors were also examined.
Shiomi
Takushi
T
Department of Applied Chemistry, Graduate School of Engineering, Nagoya University Chikusa, Nagoya, 464-8603, Japan.
Nishiyama
Hisao
H