New bioactive natural products from Coprinus micaceus.
Chemical studies on the crude methanolic extract of Coprinus micaceus, collected from the Canadian Prairie region, have resulted in the isolation of two new natural products, micaceol (1), a sterol and (Z,Z)-4-oxo-2,5-hetpadienedioic acid (2). Compound 2 was isolated for the first time as a natural product. Structures of these new compounds were established with the aid of extensive NMR spectroscopic studies. Compound 1 has shown anti-bacterial activity against Corynebacterium xerosis and Staphylococcus aureus, whereas compound 2 exhibited glutathione S-transferase inhibition.
Zahid
Shamsulhaq
S
Department of Chemistry, The University of Winnipeg, 515 Portage Avenue, Winnipeg, Manitoba, Canada R3B 2E9.
Udenigwe
Chibuike C
CC
Ata
Athar
A
Eze
Michael O
MO
Segstro
Edward P
EP
Holloway
Paul
P
D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D002264:Carboxylic Acids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D003302:Coprinus / Q000737:chemistry*; D003352:Corynebacterium / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D005982:Glutathione Transferase / Q000037:antagonists & inhibitors; D008350:Manitoba; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009904:Optical Rotation; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013211:Staphylococcus aureus / Q000187:drug effects; D013261:Sterols / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D002264:Carboxylic Acids; D004791:Enzyme Inhibitors; D010936:Plant Extracts; D013261:Sterols; D005982:Glutathione Transferase