title: COX-2 promoter region polymorphisms in multiple sclerosis: lack of association of -765G>C with disease risk.
abstract: Cyclooxygenase-2 (COX-2) is extensively expressed in multiple sclerosis lesions suggesting that regulatory variants of the COX-2 gene could be implicated in multiple sclerosis (MS). Screening of the proximal 5' regulatory region and genotyping of -765G>C and -62C>G showed that polymorphisms in this COX-2 region are unlikely to be involved in MS susceptibility.
authors: Department of Mother and Child, Biology and Genetics, Section Biology and Genetics, University of Verona, Strada Le Grazie 8, 37134 Verona, Italy. mazzolasilvia@tiscali.it
authors: S
authors: S
authors: Mazzola
authors: M Gomez
authors: MG
authors: Lira
authors: M D
authors: MD
authors: Benedetti
authors: A
authors: A
authors: Salviati
authors: S
authors: S
authors: Ottaviani
authors: G
authors: G
authors: Malerba
authors: M
authors: M
authors: Ortombina
authors: P F
authors: PF
authors: Pignatti
mesh_terms: D051546:Cyclooxygenase 2 / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D009103:Multiple Sclerosis / Q000201:enzymology / Q000235:genetics*; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic / Q000235:genetics; D012306:Risk
chemical_list: D008565:Membrane Proteins; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human