Assessment of simple movements and progression of Huntington's disease.
Instrumental measurement of simple motion sequences reflects impairment in patients with Huntington's disease (HD). The objectives were to study the progress of symptoms of HD and tapping results in 42 patients with HD, without symptomatic drug treatment over 3 years. Assessment moments were at baseline, and at years 1, 2 and 3. Unified Huntington's Disease Rating Scale (UHDRS) total score and UHDRS arm score significantly increased. Motor test outcomes considerably worsened. Instrumental test results significantly correlated with both UHDRS scores at each assessment. Assessment of simple movement sequences is an additional simple method to follow impairment in patients with HD in addition to clinical rating.
Andrich
Jürgen
J
Department of Neurology, St Josef Hospital, Ruhr University Bochum, Gudrunstrasse 56, D-44791 Bochum, Germany.
Saft
Carsten
C
Ostholt
Natalie
N
Müller
Thomas
T
D018450:Disease Progression; D005260:Female; D006801:Humans; D006816:Huntington Disease / Q000150:complications* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D019957:Motor Skills Disorders / Q000145:classification / Q000209:etiology*; D011446:Prospective Studies; D012016:Reference Values