Total synthesis of two new dihydrostilbenes from Bulbophyllum odoratissimum.
A total synthetic route of two new dihydrostilbenes 5-(2-benzo[1,3]dioxole-5-ylethyl)-6-methoxy benzo[1,3]dioxole-4-ol (1) and 5-(2-benzo[1,3]dioxole-5-ylethyl)benzo[1,3]dioxole-4,7-diol (2), which were isolated from Bulbophyllum odoratissimum Lindl. with significant cytotoxicity toward human cancer cell lines, was developed via Horner reaction etc. The natural products 1 and 2 were obtained in 10.5% and 3.3% overall yield, respectively.
Zhang
W-G
WG
Department of Pharmaceutical Chemistry, Shenyang Pharmaceutical University, Shenyang 110016, China.
Lin
J-G
JG
Niu
Z-Y
ZY
Zhao
R
R
Liu
D-L
DL
Wang
N-L
NL
Yao
X-S
XS
D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis* / Q000737:chemistry; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D029595:Orchidaceae / Q000737:chemistry*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013267:Stilbenes / Q000138:chemical synthesis* / Q000737:chemistry
D000972:Antineoplastic Agents, Phytogenic; D013267:Stilbenes