title: Clinical presentation and outcome of tuberculosis patients infected by M. africanum versus M. tuberculosis.
abstract: METHODS
  A tuberculosis (TB) case contact study in the Gambia.
  
  
  OBJECTIVE
  To test whether Mycobacterium africanum, which has lost around 68 kb compared with M. tuberculosis sensu stricto, causes less severe TB disease.
  
  
  METHODS
  We genotyped mycobacterial isolates and compared clinical and radiological characteristics as well as outcome data of M. africanum-infected TB patients with those infected with M. tuberculosis.
  
  
  RESULTS
  Of 317 index cases, 301 had a mycobacterial isolate available, 290 of which had an interpretable spoligotype pattern. Of these, 110 isolates (38%) were M. africanum and 180 (62%) were M. tuberculosis. M. africanum cases had lower body mass indices (17 vs. 17.45 for M. tuberculosis-infected patients, P = 0.029) and their radiographic disease was more extensive (96% vs. 89% had at least moderately severe radiographic changes, P = 0.031). Outcome on treatment was similar (2.8% of human immunodeficiency virus [HIV] negative M. africanum patients died on treatment vs. 3.0% of M. tuberculosis patients, P = 0.95).
  
  
  CONCLUSIONS
  M. africanum causes sputum smear-positive tuberculosis disease that is at least as severe as that caused by M. tuberculosis sensu stricto. Further clinical comparisons may be helpful in smear-negative patients and HIV-TB co-infected patients, and to identify whether there is any difference in time to develop disease.
authors: Bacterial Diseases Programme, Medical Research Council Laboratories, Banjul, The Gambia. bdejong@mrc.gm
authors: B C
authors: BC
authors: de Jong
authors: P C
authors: PC
authors: Hill
authors: A
authors: A
authors: Aiken
authors: D J
authors: DJ
authors: Jeffries
authors: A
authors: A
authors: Onipede
authors: P M
authors: PM
authors: Small
authors: R A
authors: RA
authors: Adegbola
authors: T P
authors: TP
authors: Corrah
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005714:Gambia; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009169:Mycobacterium tuberculosis; D016133:Polymerase Chain Reaction; D011859:Radiography; D016896:Treatment Outcome; D014376:Tuberculosis / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000382:microbiology*