title: Components of the metabolic syndrome, but not the metabolic syndrome per se, are associated with aortic distensibility.
abstract: OBJECTIVE
  Reduction in aortic distensibility occurs early in the atherosclerosis process and carries a poor prognosis. Metabolic syndrome is common and it is associated with increased cardiovascular mortality. The aim of this cross-sectional study was to investigate the association between metabolic syndrome and aortic distensibility.
  
  
  RESULTS
  A total of 135 subjects without diabetes were studied. Metabolic syndrome was diagnosed using the NCEP-ATP-III criteria. Aortic distensibility was assessed non-invasively by ultrasonography. Multivariate analysis, after controlling for the components of the metabolic syndrome, and, additionally, for body mass index, pulse pressure, presence of coronary artery disease, use of statins and use of angiotensin converting enzyme inhibitors and/or angiotensin receptor blockers, demonstrated an independent association between aortic distensibility and age (p<0.001), systolic blood pressure, (p=0.02), diastolic blood pressure (p=0.005), and history of hypertension (p<0.001), but not metabolic syndrome status. Moreover, there was a suggestive association with albumin-to-creatinine ratio (p=0.06).
  
  
  CONCLUSIONS
  Metabolic syndrome per se is not associated with reduction in aortic distensibility. From the components of the metabolic syndrome, only blood pressure is a strong predictor of aortic distensibility. In addition, ageing and higher values of albumin-to-creatinine ratio are also associated with low aortic distensibility.
authors: Department of Propaedeutic Medicine, Laiko Hospital, Athens University Medical School, 17 Agiou Thoma street, 115 27 Athens, Greece. ntentol@med.uoa.gr
authors: Nicholas
authors: N
authors: Tentolouris
authors: Athanasia
authors: A
authors: Papazafiropoulou
authors: Stavros
authors: S
authors: Liatis
authors: Ioannis
authors: I
authors: Moyssakis
authors: Despoina
authors: D
authors: Perrea
authors: Rigas-Philippos
authors: RP
authors: Soldatos
authors: Nicholas
authors: N
authors: Katsilambros
mesh_terms: D000367:Age Factors; D001011:Aorta / Q000000981:diagnostic imaging / Q000503:physiopathology*; D001794:Blood Pressure / Q000502:physiology*; D015992:Body Mass Index; D003404:Creatinine / Q000097:blood*; D003430:Cross-Sectional Studies; D004548:Elasticity; D005260:Female; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D016014:Linear Models; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology / Q000503:physiopathology*; D008875:Middle Aged; D015999:Multivariate Analysis; D012307:Risk Factors; D012709:Serum Albumin; D014463:Ultrasonography; D014655:Vascular Resistance
chemical_list: D012709:Serum Albumin; D003404:Creatinine