title: Colorectal neoplasia in Crohn's colitis: a retrospective comparative study with ulcerative colitis.
abstract: OBJECTIVE
  To determine the clinicopathological features of colorectal cancer (CRC) in Crohn's disease (CD).
  
  
  RESULTS
  All histological slides from surgical specimens with inflammatory bowel disease-related colorectal neoplasia examined in our hospital between 1990 and 2005 were reviewed. We identified 18 CRCs in 16 patients with CD and compared them with 57 CRCs in 41 patients with ulcerative colitis (UC). We also studied 25 patients with dysplasia without cancer (CD 2, UC 23). When CD and UC were compared, the median age at diagnosis of cancer (CD 52 years, UC 51 years), the frequency of mucinous adenocarcinoma (CD 16.7%, UC 17.5%) and the frequency of dysplasia adjacent to and distal from cancer (CD 56.3 and 37.5%, UC 65.8 and 39%, respectively) were similar. All neoplastic lesions occurred in areas affected by inflammatory bowel disease.
  
  
  CONCLUSIONS
  CRC complicating CD and UC shares many clinicopathological features, in particular similar frequencies of dysplasia, both adjacent and distal, with cancer. Thus, surveillance for patients with Crohn's colitis should be similar to that for patients with UC. Consideration should be given to a more extensive UC-like surgical approach instead of segmental resection of the involved area.
authors: AP-HP Hôpital Saint-Antoine, Service d'Anatomie et Cytologie Pathlogiques, Université Paris, Faculté de Médecine Pierre et Marie Curie, Paris, France. magali.svrcek@sat.aphp.fr
authors: M
authors: M
authors: Svrcek
authors: J
authors: J
authors: Cosnes
authors: L
authors: L
authors: Beaugerie
authors: R
authors: R
authors: Parc
authors: M
authors: M
authors: Bennis
authors: E
authors: E
authors: Tiret
authors: J-F
authors: JF
authors: Fléjou
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000150:complications / Q000473:pathology* / Q000601:surgery; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003092:Colitis / Q000150:complications / Q000473:pathology* / Q000601:surgery; D015179:Colorectal Neoplasms / Q000150:complications / Q000473:pathology* / Q000601:surgery; D003424:Crohn Disease / Q000150:complications / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011230:Precancerous Conditions / Q000473:pathology*; D012189:Retrospective Studies