Verticillin G, a new antibacterial compound from Bionectra byssicola.
A new epidithiodioxopiperazine compound named verticillin G along with the known compound verticillin D has been isolated from the mycelium of liquid fermentation cultures of a fungal strain Bionectra byssicola F 120. The structure of verticillin G was determined on the basis of MS and NMR data. Verticillin G inhibited the growth of Staphylococcus aureus including methicillin-resistant and quinolone-resistant S. aureus with MIC (microg/ml) of 3-10.
Zheng
Chang-ji
CJ
Korea Research Institute of Bioscience and Biotechnology, P.O. Box 115, Yusong, Daejeon 305-600, Republic of Korea.
Park
Soo-hee
SH
Koshino
Hiroyuki
H
Kim
Young-ho
YH
Kim
Won-gon
WG
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology*; D004220:Disulfides / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology*; D005658:Fungi / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D025282:Mycelium / Q000378:metabolism; D010879:Piperazines / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development
D000900:Anti-Bacterial Agents; D004220:Disulfides; D010879:Piperazines; C518893:verticillin G