title: Frequency of mutated allele CYP2D6*4 in the Turkish population.
abstract: The frequency of functionally important mutations and alleles of the gene coding for CYP2D6 shows wide ethnic variations. The present study aimed to determine the most common mutated allele CYP2D6*4 gene in a Turkish population of 100 unrelated subjects, by using real-time PCR with fluorescent probe. CYP2D6*4 allele was not detected in 62 subjects (62%). Among the remaining 38 subjects (38%), 4 (4%) were carriers of two *4 alleles, being homozygous for CYP2D6 and genotyped as CYP2D6*4/*4. 34 subjects (34%) were carriers of one *4 allele, being heterozygous for CYP2D6*4. The frequency of allele *4 was 0.21. These data indicate that 4% of the Turkish individuals living in the city of Bursa are carriers of two nonfunctional mutated alleles *4, being homozygous for CYP2D6*4. It is clinically important to be able to identify those individuals who are likely to have altered pharmacokinetics for CYP2D6 substrates in order to avoid adverse drug reactions.
authors: Department of Pharmacology, Uludag University Medical Faculty, Bursa, Turkey. akoseler@pau.edu.tr
authors: Aylin
authors: A
authors: Koseler
authors: Yesim Ozarda
authors: YO
authors: Ilcol
authors: Ismail H
authors: IH
authors: Ulus
mesh_terms: D019389:Cytochrome P-450 CYP2D6 / Q000235:genetics*; D005787:Gene Frequency; D005828:Genetics, Population; D006801:Humans; D011110:Polymorphism, Genetic; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014421:Turkey
chemical_list: D019389:Cytochrome P-450 CYP2D6