Effect of calcium polycarbophil on bowel function after restorative proctocolectomy for ulcerative colitis: a randomized controlled trial.
The aim of the present study was to determine if calcium polycarbophil ameliorates diarrhea after ileal J-pouch anal anastomosis for ulcerative colitis. Twenty-one randomized patients were given either bifidobacterium (3 g/day) plus calcium polycarbophil (3 g/day), in the polycarbophil group (11 patients), or bifidobacterium (3 g/day), in the control group (10 patients), p.o. for 6 months. Anal manometry was performed and bowel function (stool frequency, stool consistency, and nighttime soiling) was assessed via a questionnaire before and 1, 3, and 6 months after drug administration. Eight patients were deemed eligible in each group; five patients were excluded from the study, including two patients whose stool consistency was too firm and who experienced difficulty in defecating attributed to polycarbophil. Anal manometry and stool consistency did not change with time and did not differ between the polycarbophil and the control groups. Stool frequency decreased with time in both groups and did not differ between the groups. Nighttime soiling improved with time in the polycarbophil group but did not change in the control subjects. These results suggest that polycarbophil might be able to improve nighttime soiling without obviously affecting stool frequency and consistency after ileal J-pouch anal anastomosis for ulcerative colitis.
Shibata
Chikashi
C
Division of Biological Regulation and Oncology, Department of Surgery, Tohoku University Graduate School of Medicine, 1-1 Seiryo-Machi, Sendai, Japan. cshibata@surg1.med.tohoku.ac.jp
Funayama
Yuji
Y
Fukushima
Kouhei
K
Takahashi
Ken-Ichi
K
Ogawa
Hitoshi
H
Haneda
Sho
S
Watanabe
Kazuhiro
K
Kudoh
Katsuyoshi
K
Kohyama
Atsushi
A
Hayashi
Kei-Ichi
K
Sasaki
Iwao
I
D000180:Acrylic Resins / Q000627:therapeutic use*; D000328:Adult; D001003:Anal Canal / Q000503:physiopathology; D000930:Antidiarrheals / Q000627:therapeutic use*; D003093:Colitis, Ulcerative / Q000601:surgery*; D003967:Diarrhea / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008365:Manometry; D008875:Middle Aged; D016737:Proctocolectomy, Restorative / Q000009:adverse effects*
D000180:Acrylic Resins; D000930:Antidiarrheals; C030312:calcium polycarbophil