title: Non-invasive method to detect and locate haemorrhagic focus of GI tract.
abstract: Traditional diagnostic methods do not work well for gastrointestinal bleeding, and location of the haemorrhagic focus is even more difficult. Here a novel method with a microelectronic system is presented effectively to detect and locate the haemorrhagic focus. The outstanding advantage of this method is that it is non-invasive. The composition and working principles of the system are described in detail. Key to this system is the development of a haemoglobin (Hb) sensor. Through MEMS technology a micro haemoglobin sensor is developed and fabricated. The sensor's response performance, pH dependence and temperature dependence are tested experimentally. Initial tests suggest that the device is sufficiently sensitive to Hb concentration and insensitive to pH and temperature changes in the working range. As a result, the system has potential for development of an advanced instrument for detecting, localizing and treating gastrointestinal bleeding.
authors: 820 Institute, School of Electronic, Information and Electrical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, PR China. ajian@sjtu.edu.cn
authors: J
authors: J
authors: Shi
authors: G-Z
authors: GZ
authors: Yan
authors: K-D
authors: KD
authors: Wang
authors: Y
authors: Y
authors: Fang
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation* / Q000379:methods; D004867:Equipment Design; D019544:Equipment Failure Analysis; D006471:Gastrointestinal Hemorrhage / Q000097:blood* / Q000175:diagnosis*; D006454:Hemoglobins / Q000032:analysis*; D006801:Humans; D018670:Monitoring, Ambulatory / Q000295:instrumentation* / Q000379:methods; D010092:Oximetry / Q000295:instrumentation* / Q000379:methods; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013686:Telemetry / Q000295:instrumentation* / Q000379:methods
chemical_list: D006454:Hemoglobins