title: Gene expression patterns in pancreatic tumors, cells and tissues.
abstract: BACKGROUND
  Cancers of the pancreas originate from both the endocrine and exocrine elements of the organ, and represent a major cause of cancer-related death. This study provides a comprehensive assessment of gene expression for pancreatic tumors, the normal pancreas, and nonneoplastic pancreatic disease.
  
  
  RESULTS
  DNA microarrays were used to assess the gene expression for surgically derived pancreatic adenocarcinomas, islet cell tumors, and mesenchymal tumors. The addition of normal pancreata, isolated islets, isolated pancreatic ducts, and pancreatic adenocarcinoma cell lines enhanced subsequent analysis by increasing the diversity in gene expression profiles obtained. Exocrine, endocrine, and mesenchymal tumors displayed unique gene expression profiles. Similarities in gene expression support the pancreatic duct as the origin of adenocarcinomas. In addition, genes highly expressed in other cancers and associated with specific signal transduction pathways were also found in pancreatic tumors.
  
  
  CONCLUSIONS
  The scope of the present work was enhanced by the inclusion of publicly available datasets that encompass a wide spectrum of human tissues and enabled the identification of candidate genes that may serve diagnostic and therapeutic goals.
authors: Department of Medicine, Stanford University Medical Center, Stanford, California, United States of America. lowe@stanford.edu
authors: Anson W
authors: AW
authors: Lowe
authors: Mari
authors: M
authors: Olsen
authors: Ying
authors: Y
authors: Hao
authors: Sum P
authors: SP
authors: Lee
authors: Kyu
authors: K
authors: Taek Lee
authors: Xin
authors: X
authors: Chen
authors: Matt
authors: M
authors: van de Rijn
authors: Patrick O
authors: PO
authors: Brown
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics / Q000473:pathology / Q000601:surgery; D016477:Artifacts; D060466:Axin Protein; D018273:Carcinoma, Islet Cell / Q000235:genetics / Q000473:pathology / Q000601:surgery; D045744:Cell Line, Tumor; D004273:DNA, Neoplasm / Q000235:genetics; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D014644:Genetic Variation; D006801:Humans; D005810:Multigene Family; D020411:Oligonucleotide Array Sequence Analysis; D010179:Pancreas / Q000166:cytology / Q000502:physiology; D010190:Pancreatic Neoplasms / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D012334:RNA, Neoplasm / Q000235:genetics / Q000302:isolation & purification; D012016:Reference Values; D012097:Repressor Proteins / Q000235:genetics
chemical_list: D060466:Axin Protein; D004273:DNA, Neoplasm; D012334:RNA, Neoplasm; D012097:Repressor Proteins