Influence of ocular hypotensive eyedrops on intraocular pressure fluctuation with postural change in eyes with normal-tension glaucoma.
OBJECTIVE
To investigate the effect of various ocular hypotensive eyedrops on the intraocular pressure (IOP) fluctuations caused by the postural change in patients with normal-tension glaucoma (NTG).


METHODS
Randomized crossover single-blind study.


METHODS
Twenty-four eyes of 24 newly diagnosed NTG patients were enrolled. One of the three eyedrops including timolol maleate, latanoprost, and brinzolamide was randomly administered for one month. Each patient received all three eyedrops with a one-month washout period between the drugs. The IOP at baseline and after each treatment trial was measured in both sitting and supine positions.


RESULTS
Compared with the baseline level, the magnitude of IOP elevation associated with the postural change did not alter significantly by the application of any eyedrops (one-way repeated-measures analysis of variance, P = .288).


CONCLUSIONS
The mechanism of action underlying the IOP change with the postural change is different from the pharmacologic action of these hypotensive agents.
Kiuchi
Takahiro
T
Department of Ophthalmology, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan. kiuchi-t@md.tsukuba.ac.jp <kiuchi-t@md.tsukuba.ac.jp>
Motoyama
Yuta
Y
Oshika
Tetsuro
T
D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000008:administration & dosage*; D018592:Cross-Over Studies; D005260:Female; D005902:Glaucoma, Open-Angle / Q000188:drug therapy*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D000077338:Latanoprost; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions / Q000008:administration & dosage; D011187:Posture; D011446:Prospective Studies; D011461:Prostaglandins F, Synthetic / Q000008:administration & dosage; D016037:Single-Blind Method; D013449:Sulfonamides / Q000008:administration & dosage; D013843:Thiazines / Q000008:administration & dosage; D013999:Timolol / Q000008:administration & dosage; D014065:Tonometry, Ocular; D058609:Visual Field Tests
D000959:Antihypertensive Agents; D009883:Ophthalmic Solutions; D011461:Prostaglandins F, Synthetic; D013449:Sulfonamides; D013843:Thiazines; D000077338:Latanoprost; D013999:Timolol; C111827:brinzolamide