title: Functional characterization of human thyroid tissue with immunohistochemistry.
abstract: Immunohistochemistry provides insights in the expression of functional proteins and of their localization in normal thyroid tissue and in thyroid diseases. In hyperfunctional thyroid tissues, staining for sodium/iodide symporter (NIS), pendrin, thyroid peroxidase (TPO), and thyroglobulin (Tg) is increased. In hypofunctioning thyroid tissues, NIS staining is markedly decreased; in benign hypofunctioning adenomas, the expression of the other functional proteins is unmodified or slightly decreased, whereas their expression is profoundly decreased or absent in differentiated thyroid carcinoma.
authors: Department of Pathology, Commissariat à l'Energie Atomique LRC29V, Institut Gustave Roussy, University Paris Sud, Villejuif Cedex, France.
authors: Antongiulio
authors: A
authors: Faggiano
authors: Bernard
authors: B
authors: Caillou
authors: Ludovic
authors: L
authors: Lacroix
authors: Monique
authors: M
authors: Talbot
authors: Sebastiano
authors: S
authors: Filetti
authors: Jean-Michel
authors: JM
authors: Bidart
authors: Martin
authors: M
authors: Schlumberger
mesh_terms: D015415:Biomarkers / Q000737:chemistry; D002277:Carcinoma / Q000378:metabolism; D000939:Epitopes / Q000737:chemistry; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods*; D007453:Iodide Peroxidase / Q000378:metabolism*; D026901:Membrane Transport Proteins / Q000378:metabolism*; D009362:Neoplasm Metastasis; D011379:Prognosis; D000076988:Sulfate Transporters; D027981:Symporters / Q000378:metabolism*; D013954:Thyroglobulin / Q000378:metabolism*; D013961:Thyroid Gland / Q000473:pathology*; D013964:Thyroid Neoplasms / Q000378:metabolism; D000099209:Sodium-Iodide Symporters
chemical_list: D015415:Biomarkers; D000939:Epitopes; D007453:Iodide Peroxidase; D026901:Membrane Transport Proteins; D000076988:Sulfate Transporters; D027981:Symporters; D013954:Thyroglobulin; D000099209:Sodium-Iodide Symporters; C085609:SLC26A4 protein, human