Temporal frequency of subthreshold oscillations scales with entorhinal grid cell field spacing.
Grid cells in layer II of rat entorhinal cortex fire to spatial locations in a repeating hexagonal grid, with smaller spacing between grid fields for neurons in more dorsal anatomical locations. Data from in vitro whole-cell patch recordings showed differences in frequency of subthreshold membrane potential oscillations in entorhinal neurons that correspond to different positions along the dorsal-to-ventral axis, supporting a model of physiological mechanisms for grid cell responses.
Giocomo
Lisa M
LM
Center for Memory and Brain, Department of Psychology, Program in Neuroscience, Boston University, 2 Cummington Street, Boston, MA 02215, USA. giocomo@bu.edu
Zilli
Eric A
EA
Fransén
Erik
E
Hasselmo
Michael E
ME
D000465:Algorithms; D000818:Animals; D003198:Computer Simulation; D003712:Dendrites / Q000502:physiology; D004558:Electric Stimulation; D018728:Entorhinal Cortex / Q000166:cytology* / Q000502:physiology*; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D008433:Mathematics; D008564:Membrane Potentials; D008959:Models, Neurological; D009068:Movement; D009474:Neurons / Q000166:cytology / Q000502:physiology*; D018408:Patch-Clamp Techniques; D010507:Periodicity; D051381:Rats; D020318:Rats, Long-Evans; D013028:Space Perception; D013997:Time Factors