Preparation of short half-lived radioactive gases for medical studies.
The production of short-lived radioactive gases for medical studies is discussed with regard to the chemical reactions in suggested targets. The chemistry of target materials was studied by using the technique of radio-gas-liquid partition chromatography to analyze the product gases. Based on the chemistry of the reactions of oxygen-15 in oxygen-nitrogen mixtures, and carbon-11 in boric oxide, targets were designed for the production of oxygen-15-labeled oxygen, oxygen- 15-labeled carbon monoxide, and carbon-11-labeled carbon monoxide in high yields and high radio-chemical purity.
Welch
M J
MJ
The Edward Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri, USA.
Ter-Pogossian
M M
MM
D035843:Biomedical Research / Q000379:methods*; D002247:Carbon Isotopes / Q000138:chemical synthesis*; D005740:Gases / Q000737:chemistry*; D006207:Half-Life; D007553:Isotope Labeling / Q000379:methods*; D010104:Oxygen Radioisotopes / Q000737:chemistry*; D019275:Radiopharmaceuticals / Q000138:chemical synthesis*
D002247:Carbon Isotopes; D005740:Gases; D010104:Oxygen Radioisotopes; D019275:Radiopharmaceuticals