Radioprotective effect of Lyophyllum decastes and the effect on immunological functions in irradiated mice.
In this study, to explore the radiation protection effects of Lyophyllum Decastes Sing (LDS), a hot distilled-water extract of LDS was orally administered at a dosage of 250mg/kg every other day for a period of 2 weeks in irradiated mice. An automatic blood cell counter was used to measure white blood cells (lymphocytes, monocyte, and granulocytes) one day before X-ray irradiation, and 3 hours, 12 hours, 24 hours, 3 days, 7 days, 15 days and 30 days after irradiation. The Dunnett test was used to examine statistical significance of differences. The peripheral blood cell counts in the Lyophyllum-administered non-irradiation group revealed an increase in the numbers of leukocytes, lymphocytes and monocytes. For 2 Gy whole body radiation, a significant statistical difference was found between the X-ray group and the Lyophyllum plus X-ray group in the numbers of leukocytes, lymphocytes and monocytes. The results suggest that Lyophyllum restrains blood cell-count falling after irradiation, which is probably mediated at least in part by hemopoietic function, and NK and LAK activities seems to play a role in preventing secondary infections associated with irradiation.
Nakamura
Takashi
T
Graduate School of Health Science, Suzuka University of Medical Science, Japan.
Itokawa
Yuka
Y
Tajima
Masayuki
M
Ukawa
Yuuichi
Y
Cho
Kwang-Ho
KH
Choi
Jung-Sook
JS
Ishid
Torao
T
Gu
Yeunhwa
Y
D000284:Administration, Oral; D000363:Agaricales / Q000737:chemistry*; D000818:Animals; D001772:Blood Cell Count; D001773:Blood Cells / Q000528:radiation effects; D004195:Disease Models, Animal; D006801:Humans; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009369:Neoplasms / Q000276:immunology* / Q000532:radiotherapy*; D011837:Radiation-Protective Agents / Q000008:administration & dosage* / Q000737:chemistry; D011897:Random Allocation; D014965:X-Rays
D011837:Radiation-Protective Agents