Propylthiouracil-induced vasculitis associated with ANCA: a case report.
Propylthiouracil is a drug used in the treatment of hyperthyroidism for more than 60 years. Adverse side effects are seen in 1-5% of patients. Renal complications of the drug including glomerulonephritis and vasculitis are rarely seen. Cases of propylthiouracil-induced rapidly progressive glomerulonephritis and vasculitis are reported in association with antineutrophil cytoplasmic autoantibodies. Here we report a case of positive antineutrophil cytoplasmic autoantibodies rapidly progressive glomerulonephritis (RPGN) associated with propylthiouracil treatment.
Yuksel
Cuneyt
C
Ankara Numune Education and Research Hospital, Nephrology Clinic, Ankara, Turkey. cuneytyuks@yahoo.com
Ayli
M Deniz
MD
Yuksel
Aydan
A
Atilgan
K Gokhan
KG
Dede
Fatih
F
Guler
Serdar
S
Memis
Leyla
L
Duranay
Murat
M
D000368:Aged; D000806:Angiotensin-Converting Enzyme Inhibitors; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood*; D001284:Atrophy; D006801:Humans; D006980:Hyperthyroidism / Q000188:drug therapy*; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D007678:Kidney Glomerulus / Q000187:drug effects / Q000473:pathology; D008297:Male; D011433:Propranolol / Q000627:therapeutic use; D011441:Propylthiouracil / Q000009:adverse effects*; D017257:Ramipril / Q000627:therapeutic use; D014657:Vasculitis / Q000139:chemically induced* / Q000473:pathology*
D000806:Angiotensin-Converting Enzyme Inhibitors; D019268:Antibodies, Antineutrophil Cytoplasmic; D011441:Propylthiouracil; D011433:Propranolol; D017257:Ramipril