Systematic review and meta-analysis of cyclodiene insecticides and breast cancer.
Cyclodienes are a group of organochlorine pesticides that have been the focus of increasing numbers of breast cancer etiology studies in recent years. The aim of this systematic review and meta-analysis was to summarize and pool the results of breast cancer and cyclodiene insecticide contamination studies. We used databases from 1966 to 7/2006 and included 21 case-control studies. Pooled odds ratios or differences in means as geometric means ratios were calculated. Meta-analysis of the chemicals did not reveal any statistically significant association except for heptachlor. The heterogeneity among the different studies and the methodology limitations are discussed.
Khanjani
Narges
N
Department of Epidemiology & Preventive Medicine, Monash University, The Alfred Hospital, Melbourne, VIC, Australia. Narges.Khanjani@med.monash.edu.au
Hoving
Jan Lucas
JL
Forbes
Andrew Benjamin
AB
Sim
Malcolm Ross
MR
D001943:Breast Neoplasms / Q000139:chemically induced* / Q000453:epidemiology; D016022:Case-Control Studies; D004785:Environmental Pollutants / Q000737:chemistry / Q000633:toxicity*; D005260:Female; D006801:Humans; D006843:Hydrocarbons, Chlorinated / Q000737:chemistry / Q000633:toxicity*; D007306:Insecticides / Q000737:chemistry / Q000633:toxicity*; D015394:Molecular Structure
D004785:Environmental Pollutants; D006843:Hydrocarbons, Chlorinated; D007306:Insecticides