title: Alcohol dehydrogenase type 1C (ADH1C) variants, alcohol consumption traits, HDL-cholesterol and risk of coronary heart disease in women and men: British Women's Heart and Health Study and Caerphilly cohorts.
abstract: The alcohol dehydrogenase 1C gene (ADH1C) gamma2gamma2 variant reportedly interacts with moderate alcohol consumption to increase HDL-cholesterol levels and reduce coronary heart disease (CHD). We undertook replication studies in two large population cohorts of women and men. 3234 women and 1313 men with relevant genotypic and phenotypic data from two prospective population cohorts were genotyped for ADH1C variants. No association was found between ADH1C variants and HDL-cholesterol, blood pressure or incident CHD, although ADH1C was associated with alcohol consumption. There was no evidence of interactions between ADH1C variants and moderate alcohol intake on HDL-cholesterol, blood pressure or CHD incidence. Life-long women abstainers had adverse risk factor profiles. Our findings do not support the hypothesis that ADH1C variants are associated with CHD risk in people who drink moderately.
authors: Department of Epidemiology & Population Health, London School of Hygiene & Tropical Medicine, Keppel Street, London WC1E 7HT, UK. shah.ebrahim@lshtm.ac.uk
authors: Shah
authors: S
authors: Ebrahim
authors: Debbie A
authors: DA
authors: Lawlor
authors: Yoav Ben
authors: YB
authors: Shlomo
authors: Nicholas
authors: N
authors: Timpson
authors: Roger
authors: R
authors: Harbord
authors: Mikkel
authors: M
authors: Christensen
authors: Jamil
authors: J
authors: Baban
authors: Matt
authors: M
authors: Kiessling
authors: Ian
authors: I
authors: Day
authors: Tom
authors: T
authors: Gaunt
authors: George
authors: G
authors: Davey Smith
mesh_terms: D000368:Aged; D000426:Alcohol Dehydrogenase / Q000235:genetics*; D000428:Alcohol Drinking / Q000235:genetics*; D008076:Cholesterol, HDL / Q000097:blood*; D003327:Coronary Disease / Q000209:etiology*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011446:Prospective Studies; D012306:Risk; D013695:Temperance
chemical_list: D008076:Cholesterol, HDL; C420272:ADH1C protein, human; D000426:Alcohol Dehydrogenase