Structure comparisons of Aedes albopictus densovirus with other parvoviruses.
Parvoviridae is a family of the smallest viruses known with a wide variety of hosts. The capsid structure of the Aedes albopictus C6/36 cell densovirus (C6/36 DNV) at 1.2-nm resolution was obtained by electron cryomicroscopy (cryoEM) and three-dimensional (3D) image reconstruction. Structure comparisons between the C6/36 DNV and other parvoviruses reveal that the degree of structural similarity between C6/36 DNV and the human parvovirus B19 is higher than that between C6/36 DNV and other insect parvoviruses. The amino acid sequence comparisons of structural and non-structural proteins also reveal higher levels of similarity between C6/36 DNV and parvovirus B19 than those between C6/36 DNV and other parvoviruses. These findings indicate that C6/36 DNV is closely related to the human virus B19, and the former might evolve from the human species other than from other insect viruses.
Cheng
LingPeng
L
Department of Biomedical Engineering, School of Bioscience & Bioengineering, South China University of Technology, Guangzhou, 510640, China.
Chen
SenXiong
S
Zhou
Z H
ZH
Zhang
JingQiang
J
D000330:Aedes / Q000821:virology*; D000595:Amino Acid Sequence; D000818:Animals; D002213:Capsid / Q000737:chemistry*; D017990:Densovirus / Q000737:chemistry*; D008969:Molecular Sequence Data