title: Risk of chronic myeloid and acute leukemia mortality after exposure to ionizing radiation among workers at four U.S. nuclear weapons facilities and a nuclear naval shipyard.
abstract: A nested case-control study was conducted among workers at five U.S. nuclear facilities to evaluate leukemia mortality risk (excluding chronic lymphocytic) from ionizing radiation using worksite doses and adjusting for potential confounding. Conditional logistic regression was used to estimate the relative risk (RR) of exposed workers and the excess relative risk (ERR) per unit of radiation among 206 cases and 823 age-matched controls. Adjusting for sex and benzene, the RR of leukemia for workers receiving more than 10 mSv was higher compared to those receiving lower or no dose; however, the risk increase was attenuated in the highest dose group. The ERR per 10 mSv was 1.44% (95% CI: < -1.03%, 7.59%) but was higher for workers born after 1921 compared to workers born earlier or when excluding leukemias of uncertain type. Excluding the 7% who were high-dose workers (> 100 mSv), the sex- and benzene-adjusted ERR per 10 mSv was 6.82% (95% CI: -2.87%, 24.1%). The results suggest that risks among these nuclear workers are comparable to those observed in high-dose populations, although no evidence was observed of a positive quadratic dose-response term in this study. This large study is among the first to jointly evaluate benzene and ionizing radiation risk.
authors: National Institute for Occupational Safety and Health, Division of Surveillance, Hazard Evaluations, and Field Studies, Cincinnati, Ohio 45213, USA. MSchubauer-Berigan@cdc.gov
authors: Mary K
authors: MK
authors: Schubauer-Berigan
authors: Robert D
authors: RD
authors: Daniels
authors: Donald A
authors: DA
authors: Fleming
authors: Andrea M
authors: AM
authors: Markey
authors: James R
authors: JR
authors: Couch
authors: Steven H
authors: SH
authors: Ahrenholz
authors: Jenneh S
authors: JS
authors: Burphy
authors: Jeri L
authors: JL
authors: Anderson
authors: Chih-Yu
authors: CY
authors: Tseng
mesh_terms: D000368:Aged; D001554:Benzene / Q000633:toxicity; D015331:Cohort Studies; D005260:Female; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000209:etiology* / Q000401:mortality*; D015470:Leukemia, Myeloid, Acute / Q000209:etiology* / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D009381:Neoplasms, Radiation-Induced / Q000401:mortality*; D009688:Nuclear Reactors; D009689:Nuclear Warfare; D011839:Radiation, Ionizing; D012044:Regression Analysis; D012306:Risk
chemical_list: D001554:Benzene