Resolution of pityriasis rubra pilaris-induced cicatricial ectropion with systemic low-dose methotrexate.
OBJECTIVE
To report a case of pityriasis rubra pilaris (PRP)-induced bilateral lower eyelid cicatricial ectropion that resolved with systemic low-dose methotrexate.


METHODS
Observational case report.


METHODS
A retrospective case review of a patient with cicatricial ectropion caused by PRP.


RESULTS
A 82-year-old female presented with bilateral lower eyelid cicatricial ectropion secondary to PRP. The patient did not systemically respond to conventional oral retinoid therapy. She was treated with low-dose methotrexate and experienced dramatic resolution of her signs and symptoms, including complete resolution of her bilateral cicatricial ectropion.


CONCLUSIONS
Systemic treatment of PRP with low-dose methotrexate may result in successful treatment of cicatricial ectropion without surgery.
Durairaj
Vikram D
VD
Division of Oculoplastic and Orbital Surgery, Department of Ophthalmology, University of Colorado Health Sciences Center, Aurora, Colorado 80045, USA. vikram.durairaj@uchsc.edu <vikram.durairaj@uchsc.edu>
Horsley
Michael B
MB
D000284:Administration, Oral; D000369:Aged, 80 and over; D002921:Cicatrix / Q000188:drug therapy / Q000209:etiology; D003879:Dermatologic Agents / Q000008:administration & dosage*; D004483:Ectropion / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D006801:Humans; D008727:Methotrexate / Q000008:administration & dosage*; D010916:Pityriasis Rubra Pilaris / Q000150:complications / Q000188:drug therapy*; D012189:Retrospective Studies
D003879:Dermatologic Agents; D008727:Methotrexate