Hyponatremia-induced seizure during carbamazepine treatment.
We report the case of a 54-year-old woman who was admitted for benzodiazepine withdrawal. After 6 weeks of carbamazepine treatment (600, then 200 mg) the patient suddenly suffered from a grand mal seizure. Laboratory findings revealed a clinical significant hyponatremia of Na 125 mmol/l (baseline: 143 mmol/l). CCT and ECG were normal. To our knowledge, this is the first description of a seizure related to hyponatremia in an adult carbamazepine-treated patient.
Holtschmidt-Täschner
Bettina
B
Department of Psychiatry, Ludwig-Maximilians-University, Munich, Germany. Bettina.Taeschner@med.uni-muenchen.de
Soyka
Michael
M
D000379:Agoraphobia / Q000097:blood / Q000188:drug therapy*; D000927:Anticonvulsants / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000633:toxicity*; D001569:Benzodiazepines / Q000627:therapeutic use; D001960:Bromazepam / Q000627:therapeutic use; D002220:Carbamazepine / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004830:Epilepsy, Tonic-Clonic / Q000097:blood / Q000139:chemically induced* / Q000175:diagnosis; D005260:Female; D006801:Humans; D007010:Hyponatremia / Q000097:blood / Q000139:chemically induced* / Q000175:diagnosis; D008875:Middle Aged; D013375:Substance Withdrawal Syndrome / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy*; D019966:Substance-Related Disorders / Q000097:blood / Q000534:rehabilitation*
D000927:Anticonvulsants; D001569:Benzodiazepines; D002220:Carbamazepine; D001960:Bromazepam