Synergism of isothermal regimen and sodium succinate in experimental therapy of barbiturate coma.
In rats with experimental thiopental coma rectal temperature decreased by 9.4 degrees C, oxygen consumption 5-fold, and arteriovenous Po(2)gradient decreased 2-fold within 3 h; CO(2)accumulated in the blood and mixed type acidosis developed. Administration of sodium succinate under these conditions increased arteriovenous Po(2)gradient and reduced manifestations of metabolic acidosis. Maintenance of normal body temperature (warming) corrected primarily manifestations of respiratory acidosis. Each therapeutic agent reduced inhibition of O(2)consumption by 1/4; animal survival tended to increase from 42 to 50%. Combined use of these treatments potentiated the antiacidotic effect and increased survival to 92%. The authors conclude that hypothermia inhibits the therapeutic effect of succinate in barbiturate coma.
Reinyuk
V L
VL
Military Medical Academy, St. Petersburg. vladton@mail.ru
Shefer
T V
TV
Ivnitskii
Yu Yu
YY
D000142:Acidosis, Respiratory / Q000188:drug therapy / Q000209:etiology*; D000818:Animals; D001831:Body Temperature / Q000187:drug effects / Q000502:physiology*; D002245:Carbon Dioxide / Q000097:blood; D003128:Coma / Q000139:chemically induced / Q000150:complications / Q000188:drug therapy*; D005260:Female; D010100:Oxygen / Q000097:blood; D010101:Oxygen Consumption / Q000187:drug effects; D051381:Rats; D013386:Succinates / Q000494:pharmacology / Q000627:therapeutic use*; D013874:Thiopental / Q000633:toxicity*; D013997:Time Factors
D013386:Succinates; D002245:Carbon Dioxide; D013874:Thiopental; D010100:Oxygen