Inhibitory effect of Yangkyuk-Sanhwa-Tang on inflammatory cytokine production in peripheral blood mononuclear cells from the cerebral infarction patients.
Yangkyuk-Sanhwa-Tang (YST) has been used for the Soyangin cerebral infarction (CI) patients according to Sasang constitutional philosophy. This study investigated the effect of YST on production of various cytokines using peripheral blood mononuclear cells (PBMCs) from the Soyangin CI patients group. The amount of interleukin (IL)-1alpha, IL-1beta, IL-6, IL-8, and tumor necrosis factor-alpha increased in the lipopolysaccharide (LPS)-treated cells compared with unstimulated-cells. YST inhibited IL-1alpha, IL-1beta, and IL-8 production in PBMCs stimulated with LPS. These data suggest that YST has a regulatory effect on cytokine production, which might explain its beneficial effect in the treatment of Soyangin CI patients.
Jeong
Hyun-Ja
HJ
Department of Pharmacology College of Oriental Medicine, Institute of Oriental Medicine Kyung Hee University. Seoul. Republic of Korea.
Lee
Hye-Jung
HJ
Hong
Seung-Heon
SH
Kim
Hyung-Min
HM
Um
Jae-Young
JY
D002478:Cells, Cultured; D002544:Cerebral Infarction / Q000473:pathology*; D016207:Cytokines / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005786:Gene Expression Regulation / Q000187:drug effects*; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000187:drug effects* / Q000378:metabolism; D008070:Lipopolysaccharides / Q000494:pharmacology; D013778:Tetrazolium Salts; D013844:Thiazoles
D016207:Cytokines; D004365:Drugs, Chinese Herbal; D008070:Lipopolysaccharides; D013778:Tetrazolium Salts; D013844:Thiazoles; C022616:thiazolyl blue