Functional recovery and expression of GDNF seen in photochemically induced cerebral infarction.
Glial cell line-derived neurotrophic factor (GDNF) is a potent neurotrophic factor involved in the survival and proliferation of neurons. However, there have been few reports examining the relationship between GDNF and functional recovery after cerebral infarction. The authors investigated the change in the expression of GDNF proteins during functional recovery in rats following photochemically induced cerebral infarctions. Functional recovery for the first 14 days after the infarction was evaluated using a beam-walking test. The number of GDNF-like immunoreactive cells around the infarction were counted at various times (24 h, 72 h, 7 days, and 14 days) post-infarction. Immunohistochemical analysis of brain sections showed that the expression of GDNF-like immunoreactive cells was significantly increased in the temporal cortex until 7 days on the side ipsilateral to the infarction, and had decreased by 14 days. Likewise, the functional recovery of paralysis was substantial until 7 days post-infarction, after which the improvement was mild. Therefore, the expression of GDNF protein might have some relationship with the functional recovery of paralysis. There are great hopes that GDNF could be used as a therapeutic agent for cerebral infarction.
Horinouchi
Keisuke
K
Department of Rehabilitation and Physical Medicine, Graduate school of Medical and Dental Sciences, Kagoshima University, Sakuragaoka, Kagoshima, Japan.
Ikeda
Satoshi
S
Harada
Katsuhiro
K
Ohwatashi
Akihiko
A
Kamikawa
Yurie
Y
Yoshida
Akira
A
Nomoto
Yoshiko
Y
Etoh
Seiji
S
Kawahira
Kazumi
K
D000704:Analysis of Variance; D000818:Animals; D002452:Cell Count; D002544:Cerebral Infarction / Q000139:chemically induced / Q000378:metabolism* / Q000503:physiopathology*; D005786:Gene Expression Regulation / Q000502:physiology; D051100:Glial Cell Line-Derived Neurotrophic Factor / Q000378:metabolism*; D007150:Immunohistochemistry / Q000379:methods; D010777:Photochemistry / Q000379:methods; D011597:Psychomotor Performance / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D020127:Recovery of Function / Q000502:physiology*; D012395:Rose Bengal; D013997:Time Factors
D051100:Glial Cell Line-Derived Neurotrophic Factor; D012395:Rose Bengal