Role of NO in the systemic hemodynamic response to beta2-adrenoceptor stimulation.
Blockade of NO synthesis in most narcotized rats was followed by an increase in depressor effects (by 45%) and decrease in total peripheral resistance (by 63%) upon treatment with isopropyl norepinephrine (isoproterenol). Our results indicate that NO secretion in the endothelium modulates the systemic hemodynamic response to beta(2)-adrenoceptor stimulation.
Osadchii
L I
LI
Laboratory for Physiology of Blood Circulation, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg.
Balueva
T V
TV
Sergeev
I V
IV
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002302:Cardiac Output / Q000187:drug effects*; D007545:Isoproterenol / Q000494:pharmacology*; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors*; D051381:Rats; D018343:Receptors, Adrenergic, beta-2 / Q000378:metabolism*; D014655:Vascular Resistance / Q000187:drug effects*; D014664:Vasodilation / Q000187:drug effects*
D018343:Receptors, Adrenergic, beta-2; D019001:Nitric Oxide Synthase; D007545:Isoproterenol; D019331:NG-Nitroarginine Methyl Ester