Cutaneous granulomatous reaction to injectable hyaluronic acid gel: another case.
We report a case of a granulomatous reaction in the melolabial folds, occurring 10 days after treatment with Restylane. The patient, who had previously been treated with the same product in the last 2 years without any adverse effect, developed an unusual early fibrotic reaction that we hypothesized related to hypersensitivity after repeated use. The lesions slowly disappeared with topical steroid therapy. An improved knowledge of the modality of these uncommon adverse effects is necessary to assess the long-term safety and efficacy of this product.
Bardazzi
Federico
F
Department of Specialistic and Experimental Clinical Medicine, Division of Dermatology, University of Bologna, Italy.
Ruffato
Alberto
A
Antonucci
Angela
A
Balestri
Riccardo
R
Tabanelli
Michela
M
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D001623:Betamethasone / Q000627:therapeutic use; D003875:Drug Eruptions / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D005148:Facial Dermatoses / Q000139:chemically induced* / Q000188:drug therapy / Q000473:pathology; D005260:Female; D005782:Gels; D015745:Granuloma, Foreign-Body / Q000139:chemically induced* / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D007271:Injections, Intradermal; D008875:Middle Aged; D015595:Skin Aging; D016896:Treatment Outcome
D000305:Adrenal Cortex Hormones; D005782:Gels; D006820:Hyaluronic Acid; D001623:Betamethasone; C445361:Restylane