Glycosides of 20-deoxy derivatives of jujubogenin and pseudojujubogenin from Bacopa monniera.
A detailed phytochemical investigation of an extract of Bacopa monniera resulted in the isolation of two new dammarane glycosides along with eight known compounds. They have been identified as glycosides of the 20-deoxy derivatives of jujubogenin and pseudojujubogenin. The structures were established by different spectroscopic methods that included 1D and 2D NMR experiments. The compounds were tested for their cytotoxicity, antileishmanial, antimalarial, antioxidant, and anti-inflammatory activities. Only few compounds exhibited mild to moderate cytotoxicity towards non-cancerous kidney cell lines.
Pawar
Rahul S
RS
National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, University of Mississippi, University, MS 38677, USA.
Khan
Shabana I
SI
Khan
Ikhlas A
IA
D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D017209:Apoptosis / Q000187:drug effects*; D034681:Bacopa; D045744:Cell Line, Tumor / Q000187:drug effects; D006027:Glycosides / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D007680:Kidney Neoplasms / Q000188:drug therapy / Q000473:pathology; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D018515:Plant Leaves; D014315:Triterpenes / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use
D000972:Antineoplastic Agents, Phytogenic; D006027:Glycosides; D010936:Plant Extracts; D014315:Triterpenes; C400159:jujubogenin