title: Enantiomeric separation and determination of absolute stereochemistry of asymmetric molecules in drug discovery: building chiral technology toolboxes.
abstract: The application of Chiral Technology, or the (extensive) use of techniques or tools for the determination of absolute stereochemistry and the enantiomeric or chiral separation of racemic small molecule potential lead compounds, has been critical to successfully discovering and developing chiral drugs in the pharmaceutical industry. This has been due to the rapid increase over the past 10-15 years in potential drug candidates containing one or more asymmetric centers. Based on the experiences of one pharmaceutical company, a summary of the establishment of a Chiral Technology toolbox, including the implementation of known tools as well as the design, development, and implementation of new Chiral Technology tools, is provided.
authors: Wyeth Research, Chemical and Screening Sciences, Collegeville, PA 19426, USA. mcconno@wyeth.com
authors: Oliver
authors: O
authors: McConnell
authors: Alvin
authors: A
authors: Bach
authors: Carl
authors: C
authors: Balibar
authors: Neal
authors: N
authors: Byrne
authors: Yanxuan
authors: Y
authors: Cai
authors: Guy
authors: G
authors: Carter
authors: Michael
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authors: Chlenov
authors: Li
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authors: Di
authors: Kristi
authors: K
authors: Fan
authors: Igor
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authors: Goljer
authors: Yanan
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authors: Don
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authors: Herold
authors: Michael
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authors: Kagan
authors: Edward
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authors: Kerns
authors: Frank
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authors: Koehn
authors: Christina
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authors: Kraml
authors: Vasilios
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authors: Marathias
authors: Brian
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authors: Marquez
authors: Leonard
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authors: McDonald
authors: Lisa
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authors: Nogle
authors: Christopher
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authors: Petucci
authors: Gerhard
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authors: Schlingmann
authors: Gregory
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authors: Tawa
authors: Mark
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authors: Tischler
authors: R Thomas
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authors: Williamson
authors: Alan
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authors: Sutherland
authors: William
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authors: Watts
authors: Mairead
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authors: Young
authors: Mei-Yi
authors: MY
authors: Zhang
authors: Yingru
authors: Y
authors: Zhang
authors: Dahui
authors: D
authors: Zhou
authors: Douglas
authors: D
authors: Ho
mesh_terms: D002626:Chemistry, Pharmaceutical / Q000379:methods*; D002845:Chromatography / Q000379:methods; D002942:Circular Dichroism; D015195:Drug Design; D004345:Drug Industry / Q000379:methods*; D004583:Electrons; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008956:Models, Chemical; D008968:Molecular Conformation; D012492:Salts / Q000494:pharmacology; D013237:Stereoisomerism; D013678:Technology, Pharmaceutical / Q000379:methods
chemical_list: D012492:Salts