Hydrogels of dextran containing nonsteroidal anti-inflammatory drugs as pendant agents.
The oral administration of nonsteroidal anti-inflammatory drugs (NSAIDs) is often associated with upper gastrointestinal tract side effects. To reduce these effects and improve the therapeutic efficacy, NSAIDs are often formulated as controlled release systems. We have prepared a new formulation consisting of dextran hydrogels containing NSAIDs as pendant agents, through ultraviolet irradiation of solutions of dextran functionalized with methacrylic groups in the presence of the drug derivatized in the same way. Release studies of different drugs from this system, carried out in media simulating the gastrointestinal tract, have demonstrated that the amount of released drug is strictly related to the concentration of the polymer in the solution submitted to irradiation as well as to its derivatization degree. Our obtained data confirm that the system is able to realize a colon-specific drug delivery.
Feeney
Michelle
M
Dipartimento di Studi di Chimica e Tecnologia delle Sostanze Biologicamente Attive, Università La Sapienza, Roma, Italy.
Giannuzzo
Maria
M
Paolicelli
Patrizia
P
Casadei
Maria Antonietta
MA
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000737:chemistry*; D001241:Aspirin / Q000008:administration & dosage / Q000737:chemistry; D003106:Colon / Q000378:metabolism; D003911:Dextrans / Q000737:chemistry* / Q000528:radiation effects; D004337:Drug Carriers; D016503:Drug Delivery Systems; D020100:Hydrogels / Q000737:chemistry* / Q000528:radiation effects; D007052:Ibuprofen / Q000008:administration & dosage / Q000737:chemistry; D007202:Indicators and Reagents; D008689:Methacrylates / Q000737:chemistry; D010666:Phenylpropionates; D012997:Solvents; D013056:Spectrophotometry, Ultraviolet; D014466:Ultraviolet Rays
D000894:Anti-Inflammatory Agents, Non-Steroidal; D003911:Dextrans; D004337:Drug Carriers; D020100:Hydrogels; D007202:Indicators and Reagents; D008689:Methacrylates; D010666:Phenylpropionates; D012997:Solvents; C005044:hydroxyethyl methacrylate; C013025:hydratropic acid; D001241:Aspirin; D007052:Ibuprofen