title: Habbemines A and B, pyrrolidine alkaloids with human delta-opioid receptor binding affinity from the leaves of Elaeocarpus habbemensis.
abstract: The first phytochemical investigation of the Papua New Guinean plant Elaeocarpus habbemensis resulted in the isolation of two new pyrrolidine alkaloids, habbemines A (2) and B (3), as a 1:1 mixture of inseparable diastereomers. The structures of these compounds and their relative configurations were determined by spectroscopic means. An equimolar mixture of habbemines A and B showed human delta-opioid receptor binding affinity with an IC50 of 32.1 microM.
authors: Natural Product Discovery, Eskitis Institute, Griffith University, Brisbane, Queensland, Australia .
authors: Peter L
authors: PL
authors: Katavic
authors: Debra A
authors: DA
authors: Venables
authors: Topul
authors: T
authors: Rali
authors: Anthony R
authors: AR
authors: Carroll
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D045467:Elaeocarpaceae / Q000737:chemistry*; D006801:Humans; D015394:Molecular Structure; D010219:Papua New Guinea; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D011759:Pyrrolidines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D017465:Receptors, Opioid, delta / Q000187:drug effects*
chemical_list: D000470:Alkaloids; D011759:Pyrrolidines; D017465:Receptors, Opioid, delta; C521034:habbemine A; C521035:habbemine B