Comparative in vitro activities of carbapenem antimicrobial agents against 264 penicillin-resistant Streptococcus pneumoniae isolates from Korea.
We compared in vitro activities of carbapenems against 264 penicillin-resistant Streptococcus pneumoniae (PRSP) isolates. The MIC(50)/MIC(90) (microg/mL) values of imipenem, meropenem, ertapenem, and panipenem were 1/1, 0.25/0.25, 0.25/0.5, and 0.125/0.25, respectively. The susceptibility rates to imipenem, meropenem, and ertapenem were 0%, 85.2%, and 99.6%, respectively. Compared with imipenem and meropenem, ertapenem and panipenem had better in vitro activities against PRSP.
Choi
Sang-Ho
SH
Division of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, Republic of Korea.
Park
Su Jin
SJ
Jun
Jae-Bum
JB
Lee
Sang-Rok
SR
Jeon
Min-Hyuk
MH
Kwon
Hyun-Hee
HH
Kim
Seong Cherl
SC
Kim
Mi-Na
MN
Jeong
Jin-Yong
JY
Woo
Jun Hee
JH
Kim
Yang Soo
YS
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D015780:Carbapenems / Q000494:pharmacology*; D006801:Humans; D007723:Korea; D008826:Microbial Sensitivity Tests / Q000592:standards; D010403:Penicillin Resistance; D010406:Penicillins / Q000494:pharmacology; D011008:Pneumococcal Infections / Q000382:microbiology; D013296:Streptococcus pneumoniae / Q000187:drug effects* / Q000302:isolation & purification
D000900:Anti-Bacterial Agents; D015780:Carbapenems; D010406:Penicillins