Modulation of normal and altered hippocampal excitability states by septal networks.
The septal region of the basal forebrain plays a dual role: 1) It modulates hippocampal excitability, facilitating synaptic plasticity within hippocampal circuits. Through this mechanism, the septum facilitates diverse cognitive processes that involve hippocampal circuits. 2) Additionally, the septum maintains the hippocampal networks working within normal ranges, decreasing the probability of abnormal excitability states. Through this second mechanism, the septum prevents the occurrence of epileptic discharges. Thus, septal alterations may lead to both decreased cognitive functions and epilepsy, as observed in elderly patients affected with Alzheimer's disease.
Colom
Luis V
LV
Department of Biological Sciences, Center for Biomedical Studies, The University of Texas at Brownsville, Brownsville, Texas 78520, USA. luis.colom@utb.edu
Garrido-Sanabria
Emilio
E
D000818:Animals; D006624:Hippocampus / Q000502:physiology*; D009415:Nerve Net / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology*; D020665:Septum of Brain / Q000033:anatomy & histology*