Sex-related differences in nitric oxide content in healthy and hypertensive rats at rest and under stress conditions.
Immobilization was followed by an increase in blood NO concentration in male and female rats. After renovascular hypertension modeling blood pressure was higher and the decrease in nitric oxide concentration was more pronounced in males than in females. The levels of nitric oxide in healthy and hypertensive females at rest and during stress were higher than in males. These specific features probably contribute to higher resistance of the cardiovascular system in females to pathological changes.
Glushkovskaya-Semyachkina
O V
OV
Department of Human and Animal Physiology, N. G. Chernyshevskii Saratov State University. glushkovskaya@mail.ru
Anishchenko
T G
TG
Sindyakova
T A
TA
Leksina
O V
OV
Berdnikova
V A
VA
D000704:Analysis of Variance; D000818:Animals; D005260:Female; D006978:Hypertension, Renovascular / Q000097:blood*; D007103:Immobilization; D008297:Male; D009569:Nitric Oxide / Q000097:blood*; D009573:Nitrites / Q000097:blood; D051381:Rats; D012737:Sex Factors; D018709:Statistics, Nonparametric; D013312:Stress, Physiological / Q000097:blood*
D009573:Nitrites; D009569:Nitric Oxide