Effect of indomethacin on cerebral blood flow and development of oxygen convulsions.
Hyperbaric oxygenation modulates cerebral blood flow affecting the development of oxygen convulsions. Before hyperbaric oxygenation-induced convulsions in rats the initial decrease in blood flow gave place to hyperemia, Po(2) increased. In rats receiving cyclooxygenase inhibitor indomethacin no convulsions were observed, blood flow and Po(2)were lower than in controls. Our results indicate that indomethacin prevents hyperemia and alleviates oxygen convulsions under conditions of hyperbaric oxygenation.
Moskvin
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AN
Laboratory of Hyperbaric Physiology, I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg. moskvin@iephb.ru
Alekseeva
O S
OS
Gutsaeva
D R
DR
Khmel'nitskii
A V
AV
Sharapov
O I
OI
D000818:Animals; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D006931:Hyperbaric Oxygenation / Q000009:adverse effects*; D006940:Hyperemia / Q000517:prevention & control*; D007213:Indomethacin / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012039:Regional Blood Flow / Q000187:drug effects; D012640:Seizures / Q000139:chemically induced* / Q000188:drug therapy / Q000517:prevention & control*; D013687:Telencephalon / Q000098:blood supply* / Q000187:drug effects*
D016861:Cyclooxygenase Inhibitors; D007213:Indomethacin