[Gene angora as a modifier of the mouse hairless gene].
The interactions between mouse angora-Y (Fgf5go-Y) and hairless (hr) genes have been studied. Homozygous mutant gene Fgf5go-Y increases hair length starting on day 14 after birth. We obtained mice with genotypes +/+ hr/hr F2, +/Fgf5go-Y hr/hr and Fgf5go-Y/Fgf5go-Y hr/hr. Both +/Fgf5go-Y hr/hr and +/+ hr/hr mice began to loose hair from their heads on day 14. This further extended on the whole body. On day 21 the mice were completely deprived of hair. Therefore a single dose of gene Fgf5go-Y does not affect alopecia mice homozygous for hr. However in double homozygotes Fgf5go-Y/Fgf5gO-hr/hr alopecia started 4 days later, namely on day 18. It usually finished 10-12 days after detection of first bald patches. On days 28-30 double homozygotes have lost all the hair. Hair loss in double homozygous mice was 1,5-fold slower than in +/+ hr/hr mice. This resulted from a significant extension of anagen phase induced by a mutant homozygous gene Fgf5go-Y in morphogenesis of the hair follicle. In contrast, hr gene was expressed only at the transmission phase from anagen to catagen. Our data shows that the angora gene is a modifier of the hairless gene and this results in a strong repression of alopecia progression in double homozygous mice compared to +/+ hr/hr animals.
Koniukhov
B V
BV
Martynova
M Iu
MIu
Nesterova
A P
AP
D000483:Alleles; D000818:Animals; D003433:Crosses, Genetic; D005260:Female; D051521:Fibroblast Growth Factor 5 / Q000235:genetics*; D018628:Gene Dosage; D005838:Genotype; D006197:Hair / Q000254:growth & development*; D006720:Homozygote; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008817:Mice, Mutant Strains; D009154:Mutation; D014157:Transcription Factors / Q000235:genetics* / Q000502:physiology
C496450:Fgf5 protein, mouse; D014157:Transcription Factors; C088661:hr protein, mouse; D051521:Fibroblast Growth Factor 5