title: Developing scanning probe-based nanodevices--stepping out of the laboratory into the clinic.
abstract: This report focuses on nanotools based on the scanning force microscope (SFM) for imaging, measuring, and manipulating biological matter at the sub-micron scale. Because pathophysiological processes often occur at the (sub-) cellular scale, the SFM has opened the exciting possibility to spot diseases at a stage before they become symptomatic and cause functional impairments in the affected part of the body. Such presymptomatic detection will be key to developing effective therapies to slow or halt disease progression.
authors: M.E. Müller Institute for Structural Biology, Biozentrum, University of Basel, Switzerland.
authors: Martin
authors: M
authors: Stolz
authors: Ueli
authors: U
authors: Aebi
authors: Daniel
authors: D
authors: Stoffler
mesh_terms: D002358:Cartilage, Articular / Q000473:pathology / Q000648:ultrastructure; D003331:Coronary Vessels / Q000473:pathology / Q000648:ultrastructure; D019719:Diagnostic Equipment / Q000639:trends*; D006801:Humans; D020527:Microscopy, Scanning Probe / Q000295:instrumentation / Q000379:methods*; D036103:Nanotechnology / Q000295:instrumentation / Q000379:methods*; D013525:Surgical Instruments / Q000639:trends*