title: Mechanisms that regulate establishment, maintenance, and remodeling of dendritic fields.
abstract: Although dendrite arborization patterns are hallmarks of neuronal type and critical determinants of neuronal function, how dendritic arbors take shape is still largely unknown. Transcription factors play important roles in specifying neuronal types and have a profound influence on dendritic arbor size and complexity. The space that a dendritic arbor occupies is determined largely by a combination of growth-promoting signals that regulate arbor size, chemotropic cues that steer dendrites into the appropriate space, and neurite-neurite contacts that ensure proper representation of the dendritic field and appropriate synaptic contacts. Dendritic arbors are largely maintained over the neuron's lifetime, but in some cases, dendritic arbors are refined, in large part as a result of neuronal activity. In this review, we summarize our current understanding of the cellular and molecular mechanisms that regulate dendritic field formation and influence the shaping of dendritic arbors.
authors: Howard Hughes Medical Institute, Departments of Physiology, Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California 94143, USA.
authors: Jay Z
authors: JZ
authors: Parrish
authors: Kazuo
authors: K
authors: Emoto
authors: Michael D
authors: MD
authors: Kim
authors: Yuh Nung
authors: YN
authors: Jan
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000235:genetics; D002490:Central Nervous System / Q000166:cytology / Q000502:physiology*; D003712:Dendrites / Q000502:physiology* / Q000648:ultrastructure; D006801:Humans; D009434:Neural Pathways / Q000502:physiology* / Q000648:ultrastructure; D009473:Neuronal Plasticity / Q000502:physiology*; D015398:Signal Transduction / Q000235:genetics; D013569:Synapses / Q000502:physiology* / Q000648:ultrastructure; D009435:Synaptic Transmission / Q000502:physiology*; D014157:Transcription Factors / Q000235:genetics
chemical_list: D014157:Transcription Factors