Unfolded protein response in Drosophila: why another model can make it fly.
The unfolded protein response (UPR) is an intracellular signaling pathway that is activated in response to stress in the endoplasmic reticulum (ER). UPR can effectively cope with stress by reducing the amount of misfolded protein overload in this subcellular organelle. Significantly, ER-stress is associated with various neurodegenerative disorders, diabetes and cancer, where UPR affects the course of disease manifestation in many cases. While significant progress has been made in various experimental systems over the years, suitable models for in vivo analyses of UPR and disease remain scarce. In this regard, recent developments of Drosophila markers and genetic tools for UPR studies provide powerful means to investigate the connection between UPR and disease in vivo. Here, we review the molecular components of the Drosophila UPR as well as the disease models that may be affected by this signaling pathway.
Ryoo
Hyung Don
HD
New York University School of Medicine, Department of Cell Biology, New York, New York 10016, USA. hd.ryoo@med.nyu.edu
Steller
Hermann
H
D051701:Activating Transcription Factor 4 / Q000235:genetics; D000818:Animals; D017209:Apoptosis / Q000235:genetics; D004195:Disease Models, Animal; D004330:Drosophila / Q000235:genetics*; D029721:Drosophila Proteins / Q000096:biosynthesis* / Q000235:genetics; D004721:Endoplasmic Reticulum / Q000235:genetics / Q000378:metabolism*; D005786:Gene Expression Regulation / Q000235:genetics; D017510:Protein Folding; D015398:Signal Transduction / Q000235:genetics
D029721:Drosophila Proteins; D051701:Activating Transcription Factor 4