title: The effects of a nucleotide supplement on the immune and metabolic response to short term, high intensity exercise performance in trained male subjects.
abstract: OBJECTIVE
  The aim of this work was to determine the ergogenic effects of a nucleotide supplement on the metabolic and immune responses to short term high intensity exercise in volunteer, trained, male subjects.
  
  
  METHODS
  Thirty moderately trained male subjects were randomly divided into 3 equal sized groups, control (C), placebo (P) or experimental (E). Each subject undertook a 2 min maximal exercise test prior to, and after 60 days, on either a nucleotide (E) or placebo supplement. Prior to exercise testing unstimulated saliva samples and blood samples were taken. Saliva was analysed for cortisol and IgA, while blood was analysed for lactate, lactate dehydrogenase and creatine kinase.
  
  
  RESULTS
  The postexercise C value was significantly higher than the pre-exercise concentration (P<0.0001; for C, P, and E). In the postsupplement C analysis, the E postexercise group was significantly lower than either the C (P<0.005) or the P group (P<0.05). In the pre- and postsupplementation periods, the pre-exercise SIgA values were significantly higher than the postexercise values (P<0.0001). However, in the postsupplementation period, the SIgA value in the E group was significantly higher than either the P (P<0.05) or C (P<0.05) groups. There were no significant changes in blood lactate, lactate dehydrogenase, or creatine kinase concentrations post supplementation.
  
  
  CONCLUSIONS
  We concluded that a chronically ingested nucleotide supplement blunts the response of the hormones associated with physiological stress.
authors: Department of Sport Science, University of Hull, Hull, UK. l.mcnaughton@hull.ac.uk
authors: L
authors: L
authors: Mc Naughton
authors: D
authors: D
authors: Bentley
authors: P
authors: P
authors: Koeppel
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D003402:Creatine Kinase / Q000097:blood; D019587:Dietary Supplements; D005080:Exercise Test; D006801:Humans; D006854:Hydrocortisone / Q000032:analysis; D007070:Immunoglobulin A / Q000032:analysis; D007773:Lactates / Q000097:blood; D008297:Male; D009711:Nucleotides / Q000008:administration & dosage*; D010807:Physical Endurance / Q000187:drug effects*; D012463:Saliva / Q000737:chemistry
chemical_list: D007070:Immunoglobulin A; D007773:Lactates; D009711:Nucleotides; D003402:Creatine Kinase; D006854:Hydrocortisone