title: Control of quorum sensing by a Burkholderia pseudomallei multidrug efflux pump.
abstract: The Burkholderia pseudomallei KHW quorum-sensing systems produced N-octanoyl-homoserine lactone, N-decanoyl-homoserine lactone, N-(3-hydroxy)-octanoyl-homoserine lactone, N-(3-hydroxy)-decanoyl-homoserine lactone, N-(3-oxo)-decanoyl-homoserine lactone, and N-(3-oxo)-tetradecanoyl-homoserine lactone. The extracellular secretion of these acyl-homoserine lactones is dependent absolutely on the function of the B. pseudomallei BpeAB-OprB efflux pump.
authors: Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 8 Medical Drive, Singapore 117597, Singapore.
authors: Ying Ying
authors: YY
authors: Chan
authors: Hao Sheng
authors: HS
authors: Bian
authors: Theresa May Chin
authors: TM
authors: Tan
authors: Margrith E
authors: ME
authors: Mattmann
authors: Grant D
authors: GD
authors: Geske
authors: Jun
authors: J
authors: Igarashi
authors: Tomomi
authors: T
authors: Hatano
authors: Hiroaki
authors: H
authors: Suga
authors: Helen E
authors: HE
authors: Blackwell
authors: Kim Lee
authors: KL
authors: Chua
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives / Q000378:metabolism; D001425:Bacterial Outer Membrane Proteins / Q000235:genetics / Q000378:metabolism*; D016957:Burkholderia pseudomallei / Q000235:genetics / Q000378:metabolism* / Q000502:physiology; D002851:Chromatography, High Pressure Liquid; D015964:Gene Expression Regulation, Bacterial; D006714:Homoserine / Q000031:analogs & derivatives / Q000378:metabolism; D007783:Lactones / Q000378:metabolism; D009154:Mutation; D053038:Quorum Sensing / Q000235:genetics / Q000502:physiology*
chemical_list: D001425:Bacterial Outer Membrane Proteins; D007783:Lactones; C091088:N-octanoylhomoserine lactone; C088386:homoserine lactone; D006714:Homoserine; D015107:4-Butyrolactone