Cellular therapy using microglial cells.
Recent insights into the function and dysfunction of microglia may inform future therapies to combat neurodegeneration. We hypothesise how different aspects of microglial activity including migration, activation, oxidative response, phagocytosis, proteolysis, and replenishment could be targeted by novel therapeutic approaches. A combined approach is suggested, encompassing opsonization and anti-inflammatory strategies in conjunction with an engineering of microglial precursors. Xenoproteases for bioremediation could be used to enhance intracellular and extracellular proteolytic capacity. The capacity of microglial precursors to cross the blood-brain barrier and to home in on sites of neural damage and inflammation might prove to be particularly useful for future therapeutic strategies.
Schloendorn
John
J
Biodesign Institute, Arizona State University, Tempe, Arizona 85287, USA. Zauberkugel@yahoo.com
Sethe
Sebastian
S
Stolzing
Alexandra
A
D000818:Animals; D006801:Humans; D007249:Inflammation / Q000276:immunology; D017628:Microglia / Q000276:immunology / Q000502:physiology* / Q000637:transplantation*; D010587:Phagocytosis