Mechanisms that regulate establishment, maintenance, and remodeling of dendritic fields.
Although dendrite arborization patterns are hallmarks of neuronal type and critical determinants of neuronal function, how dendritic arbors take shape is still largely unknown. Transcription factors play important roles in specifying neuronal types and have a profound influence on dendritic arbor size and complexity. The space that a dendritic arbor occupies is determined largely by a combination of growth-promoting signals that regulate arbor size, chemotropic cues that steer dendrites into the appropriate space, and neurite-neurite contacts that ensure proper representation of the dendritic field and appropriate synaptic contacts. Dendritic arbors are largely maintained over the neuron's lifetime, but in some cases, dendritic arbors are refined, in large part as a result of neuronal activity. In this review, we summarize our current understanding of the cellular and molecular mechanisms that regulate dendritic field formation and influence the shaping of dendritic arbors.
Parrish
Jay Z
JZ
Howard Hughes Medical Institute, Departments of Physiology, Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California 94143, USA.
Emoto
Kazuo
K
Kim
Michael D
MD
Jan
Yuh Nung
YN
D000818:Animals; D002454:Cell Differentiation / Q000235:genetics; D002490:Central Nervous System / Q000166:cytology / Q000502:physiology*; D003712:Dendrites / Q000502:physiology* / Q000648:ultrastructure; D006801:Humans; D009434:Neural Pathways / Q000502:physiology* / Q000648:ultrastructure; D009473:Neuronal Plasticity / Q000502:physiology*; D015398:Signal Transduction / Q000235:genetics; D013569:Synapses / Q000502:physiology* / Q000648:ultrastructure; D009435:Synaptic Transmission / Q000502:physiology*; D014157:Transcription Factors / Q000235:genetics
D014157:Transcription Factors