Normal cerebrospinal fluid levels of hypocretin-1 (orexin A) in patients with fibromyalgia syndrome.
BACKGROUND
The hypothalamic neuropeptide hypocretin (orexin) modulates sleep-wake, feeding and endocrine functions. Cerebrospinal fluid (CSF) hypocretin-1 (Hcrt-1) concentrations are low in patients with narcolepsy-cataplexy, a sleep disorder characterized by hypersomnolence and rapid eye movement (REM) sleep abnormalities.


METHODS
We determined CSF Hcrt-1 concentrations of patients with the fibromyalgia syndrome (FMS), a condition characterized by fatigue, insomnia and in some cases daytime hypersomnolence.


RESULTS
Basal CSF levels of Hcrt-1 in FMS did not differ from those in healthy normal controls.


CONCLUSIONS
These findings suggest that abnormally low Hcrt-1 is not a likely cause of fatigue in FMS.
Taiwo
Oludare B
OB
University of Minnesota, Department of Veterinary and Biomedical Sciences, Rm 295, Animal Science/Veterinary Medicine Building, 1988 Fitch Avenue, St. Paul, MN 55113, USA.
Russell
I Jon
IJ
Mignot
Emmanuel
E
Lin
Ling
L
Michalek
Joel E
JE
Haynes
Wanda
W
Xiao
Yangming
Y
Zeitzer
Jamie M
JM
Larson
Alice A
AA
D000328:Adult; D000368:Aged; D006970:Disorders of Excessive Somnolence / Q000134:cerebrospinal fluid; D005260:Female; D005356:Fibromyalgia / Q000134:cerebrospinal fluid* / Q000175:diagnosis; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000134:cerebrospinal fluid*; D008297:Male; D008875:Middle Aged; D009479:Neuropeptides / Q000134:cerebrospinal fluid*; D000068797:Orexins; D011863:Radioimmunoassay; D012016:Reference Values; D012895:Sleep, REM / Q000502:physiology; D013223:Statistics as Topic
C000596229:HCRT protein, human; D047908:Intracellular Signaling Peptides and Proteins; D009479:Neuropeptides; D000068797:Orexins