title: Comparative in vitro activities of carbapenem antimicrobial agents against 264 penicillin-resistant Streptococcus pneumoniae isolates from Korea.
abstract: We compared in vitro activities of carbapenems against 264 penicillin-resistant Streptococcus pneumoniae (PRSP) isolates. The MIC(50)/MIC(90) (microg/mL) values of imipenem, meropenem, ertapenem, and panipenem were 1/1, 0.25/0.25, 0.25/0.5, and 0.125/0.25, respectively. The susceptibility rates to imipenem, meropenem, and ertapenem were 0%, 85.2%, and 99.6%, respectively. Compared with imipenem and meropenem, ertapenem and panipenem had better in vitro activities against PRSP.
authors: Division of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, Republic of Korea.
authors: Sang-Ho
authors: SH
authors: Choi
authors: Su Jin
authors: SJ
authors: Park
authors: Jae-Bum
authors: JB
authors: Jun
authors: Sang-Rok
authors: SR
authors: Lee
authors: Min-Hyuk
authors: MH
authors: Jeon
authors: Hyun-Hee
authors: HH
authors: Kwon
authors: Seong Cherl
authors: SC
authors: Kim
authors: Mi-Na
authors: MN
authors: Kim
authors: Jin-Yong
authors: JY
authors: Jeong
authors: Jun Hee
authors: JH
authors: Woo
authors: Yang Soo
authors: YS
authors: Kim
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D015780:Carbapenems / Q000494:pharmacology*; D006801:Humans; D007723:Korea; D008826:Microbial Sensitivity Tests / Q000592:standards; D010403:Penicillin Resistance; D010406:Penicillins / Q000494:pharmacology; D011008:Pneumococcal Infections / Q000382:microbiology; D013296:Streptococcus pneumoniae / Q000187:drug effects* / Q000302:isolation & purification
chemical_list: D000900:Anti-Bacterial Agents; D015780:Carbapenems; D010406:Penicillins