[Topical immunosuppressives after penetrating keratoplasty].
Topical steroids are routinely used in the postoperative treatment following penetrating keratoplasty. Due to the known side effects such as steroid-response glaucoma, cataract, and surface disorders, a broader armamentarium of topical immunomodulating drugs with comparable efficacy, better tolerance and less side effects is desirable. Cyclosporine A and FK506 eye drops are a promising alternative. A new approach involves subconjunctival drug delivering implants and locally applied antiangiogenic substances, which still have to be tested in clinical studies.
Birnbaum
F
F
Universitätsaugenklinik Freiburg, 79106, Freiburg. florian.birnbaum@uniklinik-freiburg.de
Reis
A
A
Reinhard
T
T
D000287:Administration, Topical; D000818:Animals; D003318:Corneal Opacity / Q000188:drug therapy* / Q000276:immunology; D006084:Graft Rejection / Q000188:drug therapy* / Q000276:immunology; D006085:Graft Survival / Q000187:drug effects; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage* / Q000009:adverse effects; D015948:Keratoplasty, Penetrating; D011183:Postoperative Complications / Q000188:drug therapy* / Q000276:immunology
D007166:Immunosuppressive Agents