title: Serum endothelin-1 and transforming growth factor-beta levels in the newborns with respiratory distress.
abstract: The purpose of this present study was to evaluate the serum levels of ET-1 and TGF-beta in the newborns with respiratory distress. In this study, newborns with respiratory distress hospitalized into the Newborn Intensive Care Unit were included. The highest values of ET-1 and TGF-beta were obtained from newborns with diagnosis as meconium aspiration syndrome (5.70 +/- 5.87 pg/mL and 3.75 +/- 1.94 pg/mL, resp) in the sample obtained in the first six hours after birth, and these are statistically different from control group (P < .05). Also, same results were obtained for newborns with respiratory distress syndrome (3.37 +/- 1.59 pg/mL and 2.05 +/- 0.98 pg/mL, resp). After oxygen treatment, ET-1 values obtained in the first six hours of life were decreased regularly in the following days (P < .05). In the differentiating diagnosis of the respiratory distress of newborns, the investigation of ET-1 and TGF-beta levels is meaningful. The ET-1 levels investigated in the first six hours is more useful in determining the prognosis, and repeating ET-1 levels in the following days is more meaningful to determine clinical response.
authors: Deaprtment of Pediatrics, Firat University Medical Faculty, Elazig, Turkey.
authors: Derya
authors: D
authors: Benzer
authors: A Denizmen
authors: AD
authors: Aygun
authors: Ahmet
authors: A
authors: Godekmerdan
authors: A Nese Citak
authors: AN
authors: Kurt
authors: Saadet
authors: S
authors: Akarsu
authors: Erdal
authors: E
authors: Yilmaz
mesh_terms: D016022:Case-Control Studies; D003937:Diagnosis, Differential; D019332:Endothelin-1 / Q000097:blood*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D018836:Inflammation Mediators / Q000097:blood; D007363:Intensive Care Units, Neonatal; D008297:Male; D008471:Meconium Aspiration Syndrome / Q000097:blood / Q000175:diagnosis; D012127:Respiratory Distress Syndrome, Newborn / Q000097:blood* / Q000175:diagnosis; D016212:Transforming Growth Factor beta / Q000097:blood*; D014421:Turkey
chemical_list: D019332:Endothelin-1; D018836:Inflammation Mediators; D016212:Transforming Growth Factor beta