No significant association between the genetic polymorphisms in the GSK-3 beta gene and schizophrenia in the Chinese population.
The GSK-3 beta gene encodes a protein kinase which is abundant in the brain, and its product is involved in signal transduction cascades of neuronal cell development, energy metabolism and body pattern formation. Previous studies have suggested that GSK-3 beta might act as a potential candidate locus for schizophrenia susceptibility. We genotyped six SNPs within the gene and conducted a case-control study involving 329 schizophrenic patients and 288 healthy subjects in the Chinese population. We examined allele and genotype frequencies and haplotype distributions in the subtype of paranoid schizophrenic patients as well as schizophrenic subjects in general. Our results fail to replicate the association of the GSK-3 beta gene with susceptibility to schizophrenia in the Chinese population.
Meng
Junwei
J
Bio-X Center, Shanghai Jiao Tong University, Haoran Building, 1954 Huashan Road, Shanghai 200030, PR China.
Shi
Yongyong
Y
Zhao
Xinzhi
X
Zhou
Jian
J
Zheng
Yonglan
Y
Tang
Ruqi
R
Ma
Gang
G
Zhu
Xuming
X
He
Zangdong
Z
Wang
Zhe
Z
Xu
Yifeng
Y
Feng
Guoyin
G
He
Lin
L
D000328:Adult; D017668:Age of Onset; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D035061:Control Groups; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D038362:Glycogen Synthase Kinase 3 / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D012559:Schizophrenia / Q000453:epidemiology / Q000235:genetics*; D012563:Schizophrenia, Paranoid / Q000453:epidemiology / Q000235:genetics
D038362:Glycogen Synthase Kinase 3