title: Tambouranolide, a new cytotoxic hydroxybutanolide from a Tambourissa sp. (Monimiaceae).
abstract: A new cytotoxic hydroxybutanolide, tambouranolide, has been isolated by solid phase extraction from an ethanol extract of the dried roots of a species of Tambourissa (Monimiaceae) from the Madagascar rainforest. The structure was elucidated through the interpretation of spectral data and its comparison to data reported in the literature for related molecules. The compound showed moderate in vitro cytotoxicity with an IC50 of 8 micro g mL(-1) in the A2780 human ovarian cancer cell line assay.
authors: Department of Chemistry, M/C 0212, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.
authors: Brent J
authors: BJ
authors: Yoder
authors: Shugeng
authors: S
authors: Cao
authors: Andrew
authors: A
authors: Norris
authors: James S
authors: JS
authors: Miller
authors: Fidisoa
authors: F
authors: Ratovoson
authors: Rabodo
authors: R
authors: Andriantsiferana
authors: Vincent E
authors: VE
authors: Rasamison
authors: David G I
authors: DG
authors: Kingston
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D029585:Monimiaceae / Q000737:chemistry*; D019906:Nuclear Magnetic Resonance, Biomolecular; D009904:Optical Rotation; D018517:Plant Roots / Q000737:chemistry; D052616:Solid Phase Extraction; D016339:Spectrometry, Mass, Fast Atom Bombardment
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D005663:Furans