[A Multiple endocrine neoplasia type-1 observatory in a French-speaking area. A tool from the Endocrine Tumor study Group (GTE)].
Wermer's syndrome or Multiple Endocrine Neoplasia Type-1 (MEN1) is an autosomal dominant inherited disease, related to mutations in MEN1, an approximately 10-kb gene encoding menin, localized on chromosome 11q13. The Endocrine Tumor Group (GTE) has set up a MEN1 observatory of 1001 regularly followed MEN1 cases. This observatory aims at registering and evaluating MEN1 cases in a large cohort. Any new study on a particular unexplored aspect of the disease may be proposed by a physician to the GTE. This article describes the way to diagnose a new MEN1 case and to register it. Procedures for participating in a new study are presented. Some original results are quoted.
Goudet
P
P
Service de chirurgie viscérale et endocrinienne, hôpital Général, CHU de Dijon, 3, rue du Faubourg-Raines, BP 1519, 21033 Dijon cedex, France. pierre.goudet@chu-dijon.fr
Bonithon
C
C
Costa
A
A
Cadiot
G
G
Baudin
E
E
Murat
A
A
Delemer
B
B
Tabarin
A
A
Lecomte
P
P
Calender
A
A
D002880:Chromosomes, Human, Pair 11 / Q000235:genetics; D015331:Cohort Studies; D005602:France / Q000453:epidemiology; D006801:Humans; D018761:Multiple Endocrine Neoplasia Type 1 / Q000453:epidemiology* / Q000235:genetics*; D012042:Registries