title: Magnesium hydroxide/aluminium hydroxide-containing antacid does not affect the pharmacokinetics of the targeted phosphodiesterase 4 inhibitor roflumilast.
authors: Department of Exploratory Medicine, ALTANA Pharma AG, Byk-Gulden-Str. 2, 78467 Konstanz, Germany.
authors: Nassr
authors: N
authors: Nassr
authors: Gezim
authors: G
authors: Lahu
authors: Andreas
authors: A
authors: Hünnemeyer
authors: Oliver
authors: O
authors: von Richter
authors: Dietrich
authors: D
authors: Knoerzer
authors: Felix
authors: F
authors: Reutter
authors: Karl
authors: K
authors: Zech
authors: Robert
authors: R
authors: Hermann
mesh_terms: D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000037:antagonists & inhibitors; D000328:Adult; D000536:Aluminum Hydroxide / Q000009:adverse effects / Q000494:pharmacology*; D000631:Aminopyridines / Q000097:blood / Q000493:pharmacokinetics*; D000863:Antacids / Q000009:adverse effects / Q000494:pharmacology*; D001549:Benzamides / Q000097:blood / Q000493:pharmacokinetics*; D018592:Cross-Over Studies; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4; D003521:Cyclopropanes / Q000097:blood / Q000493:pharmacokinetics; D004347:Drug Interactions; D005260:Female; D006801:Humans; D008276:Magnesium Hydroxide / Q000009:adverse effects / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D010726:Phosphodiesterase Inhibitors / Q000009:adverse effects / Q000097:blood / Q000493:pharmacokinetics*
chemical_list: D000631:Aminopyridines; D000863:Antacids; D001549:Benzamides; D003521:Cyclopropanes; D010726:Phosphodiesterase Inhibitors; C424423:Roflumilast; D000536:Aluminum Hydroxide; D015105:3',5'-Cyclic-AMP Phosphodiesterases; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4; C517734:roflumilast N-oxide; D008276:Magnesium Hydroxide