Agmatine blocks morphine-evoked hyperthermia in rats.
The present study investigated the effect of agmatine on morphine-evoked hyperthermia in rats. Morphine (4 mg/kg, s.c.) produced hyperthermia by activating mu opioid receptors. Agmatine (10 and 50 mg/kg, i.p.) was ineffective. For combined administration, agmatine decreased morphine-evoked hyperthermia. The effect was prevented by idazoxan (5 mg/kg, i.p.), an imidazoline/alpha(2)-adrenoeceptor receptor antagonist. Yohimbine, an alpha(2)-adrenoeceptor antagonist, did not prevent the attenuation of morphine-evoked hyperthermia by agmatine. The present data provide pharmacological evidence that agmatine blocks the hyperthermic effect of morphine by activating imidazoline receptors.
Rawls
Scott M
SM
Department of Pharmaceutical Sciences, Temple University School of Pharmacy, Philadelphia, PA 19140, USA. scott.rawls@temple.edu
Amin
Manisha
M
Zisk
Jacob
J
D000376:Agmatine / Q000494:pharmacology*; D018712:Analgesics, Non-Narcotic / Q000494:pharmacology*; D000704:Analysis of Variance; D000818:Animals; D001679:Biogenic Amines / Q000494:pharmacology; D001833:Body Temperature Regulation / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005334:Fever / Q000139:chemically induced / Q000517:prevention & control*; D019329:Idazoxan / Q000494:pharmacology; D054755:Imidazoline Receptors; D008297:Male; D009020:Morphine; D051381:Rats; D017207:Rats, Sprague-Dawley; D011955:Receptors, Drug / Q000187:drug effects*; D017450:Receptors, Opioid, mu / Q000187:drug effects; D015016:Yohimbine / Q000494:pharmacology
D018712:Analgesics, Non-Narcotic; D001679:Biogenic Amines; D054755:Imidazoline Receptors; D011955:Receptors, Drug; D017450:Receptors, Opioid, mu; D015016:Yohimbine; D000376:Agmatine; D009020:Morphine; D019329:Idazoxan