Role of nuclear factor kappaB in the central nervous system.
The aim of this review was to assemble current literature data on nuclear factor kappa B (NF-kappaB). Many authors believe that NF-kappaB, a transcription factor, has essential influence on the regulation of numerous genes in the organism. In this review, we have focused on the role of NF-kappaB and its target genes in the central nervous system functioning. Unfortunately, the contribution of NF-kappaB to neuroprotection or to neurodegeneration is not clear, yet. Therefore, its exact role in these processes and potential applications in pharmacology are still to be determined.
Małek
Robert
R
Department of Pathophysiology, Medical University, Jaczewskiego 8, PL 20-090 Lublin, Poland.
Borowicz
Kinga K
KK
Jargiełło
Małgorzata
M
Czuczwar
Staniław J
SJ
D000818:Animals; D017209:Apoptosis / Q000235:genetics; D001921:Brain / Q000378:metabolism* / Q000473:pathology; D002493:Central Nervous System Diseases / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D005786:Gene Expression Regulation; D006801:Humans; D016328:NF-kappa B / Q000037:antagonists & inhibitors / Q000235:genetics / Q000502:physiology
D016328:NF-kappa B