Autoimmunity and beta cell regeneration in mouse and human type 1 diabetes: the peace is not enough.
Accumulating data from animal models of type 1 diabetes and some findings from clinical studies suggest that autoimmune destruction of islet beta cells is associated with enhanced beta cell regeneration. Successful immune therapies, aimed at preservation of islet cell mass, result in a remarkable reduction of beta cell regeneration. Treated or not, as long as the task of treatment is limited by "making peace" with autoimmunity, the process of beta cell loss continues. Additional therapeutic modalities capable of stimulating beta cell regeneration in the absence of active autoimmune destruction are urgently needed.
Ablamunits
Vitaly
V
Section of Immunobiology, Department of Medicine, Yale University School of Medicine, New Haven, CT 06520, USA.
Sherry
Nicole A
NA
Kushner
Jake A
JA
Herold
Kevan C
KC
D000818:Animals; D015551:Autoimmunity; D003921:Diabetes Mellitus, Experimental / Q000276:immunology* / Q000473:pathology / Q000503:physiopathology; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology* / Q000473:pathology; D051273:Glucose Transporter Type 2 / Q000032:analysis; D006801:Humans; D007328:Insulin / Q000032:analysis; D050417:Insulin-Secreting Cells / Q000276:immunology / Q000473:pathology* / Q000502:physiology; D007515:Islets of Langerhans / Q000276:immunology / Q000473:pathology / Q000503:physiopathology; D008297:Male; D051379:Mice; D016688:Mice, Inbred NOD; D012038:Regeneration
D051273:Glucose Transporter Type 2; D007328:Insulin