Loss of imprinting of insulin-like growth factor II is associated with increased risk of proximal colon cancer.
The aim of this study was to determine the clinicopathological features of sporadic colon cancers with loss of imprinting (LOI) of insulin-like growth factor II (IGF-II) in Chinese patients. DNA from peripheral blood leucocytes and RNA from tumours were amplified and then digested with ApaI to determine the LOI status. Of the 316 patients enrolled for analysis, 149 were informative for IGF-II LOI. The positive rate of IGF-II LOI of colon cancer tissue was 47% (70/149) in Chinese patients. Proximal colon (64%) cancers were more likely to have LOI of IGF-II in tumour than distal colon (40.9%) cancers (odds ratio (OR)=2.60, 95% confidence intervals (CI)=1.21-5.56, p=0.014). LOI of IGF-II in tumours was also associated with more advanced diseases (OR=2.90, 95% CI=1.05-8.04, p=0.04). IGF-II LOI is present in high frequency in Chinese colon cancer patients, especially those with proximal cancer.
Liou
Jyh-Ming
JM
Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan.
Wu
Ming-Shiang
MS
Lin
Jaw-Town
JT
Wang
Hsiu-Po
HP
Huang
Shih-Pei
SP
Chiu
Han-Mo
HM
Lee
Yi-Chia
YC
Lin
Yen-Bo
YB
Shun
Chia-Tung
CT
Liang
Jin-Tung
JT
D000368:Aged; D003110:Colonic Neoplasms / Q000235:genetics*; D004586:Electrophoresis; D005260:Female; D018392:Genomic Imprinting / Q000235:genetics*; D006801:Humans; D018971:Insulin-Like Growth Factor Binding Protein 2 / Q000235:genetics*; D008297:Male; D018895:Microsatellite Repeats; D008875:Middle Aged; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012307:Risk Factors
D018971:Insulin-Like Growth Factor Binding Protein 2