Intrapartum stillbirths in hospital unrelated to uteroplacental vascular insufficiency.
The aim of this study was to investigate the causes of intrapartum asphyxia and its relationship to placental abnormalities. Twenty intrapartum fetal death autopsies carried out over a 10-year period in one hospital pathology department associated with a large obstetric unit were reviewed. All the intrapartum fetal deaths occurred in the hospital, while the mothers were being monitored during and after labor. On morphologic grounds, all the fetal deaths were thought to be caused by intrapartum asphyxia. Seven of the intrapartum fetal deaths were associated with intrauterine infection causing funisitis, and in 6 of these cases, chorioamnionitis was present as well. Two cases were caused by placental abruption, and 1 case was caused by cord compression. In 8 of the 10 remaining cases in which the placenta was examined, a minor placental abnormality was detected in only 1 case. Five of the 10 cases had a mild astrocytosis in the intracerebral periventricular white matter, suggestive of intrauterine ischemia at least 12 hours before death. Five of the 10 cases were thought by the delivering obstetrician to have umbilical cord abnormalities. The main conclusions from this study are that, except in cases of intrauterine infection, placental vascular abnormalities are unlikely to be associated with intrapartum asphyxia leading to fetal death during labor. The number of cases with umbilical cord abnormalities raises the possibility that cord accidents may be a significant cause of intrapartum stillbirth.
Burke
Christopher J
CJ
Department of Pathology, Mater Public Hospitals, Brisbane, Australia. christopher.burke@mater.org.au
Tannenberg
A E T
AE
D000037:Abruptio Placentae / Q000473:pathology; D001237:Asphyxia / Q000150:complications; D001921:Brain / Q000473:pathology*; D005260:Female; D005313:Fetal Death / Q000209:etiology*; D006801:Humans; D010920:Placenta / Q000098:blood supply* / Q000473:pathology; D021041:Placental Circulation / Q000502:physiology*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000473:pathology / Q000503:physiopathology; D011251:Pregnancy Complications, Infectious / Q000473:pathology / Q000503:physiopathology*; D050497:Stillbirth; D014470:Umbilical Cord / Q000473:pathology