Phosphoinositide 3-kinase-dependent regulation of phospholipase Cgamma.
Activation of the enzyme PLC (phospholipase C) leads to the formation of second messengers Ins(1,4,5)P(3) and diacylglycerol. RTKs (receptor tyrosine kinases) activate this reaction through PLCgamma isoenzymes. It has been shown that PI3K (phosphoinositide 3-kinase) may regulate PLCgamma activity through the interaction of PI3K product PtdIns(3,4,5)P(3) and the PLCgamma PH domain (pleckstrin homology domain). Here, we analyse the potential functional roles of the PI3K/PLC pathway.
Maffucci
T
T
Centre for Cardiovascular Biology and Medicine, Division of Medicine, The Rayne Institute, University College London, London, UK. t.maffucci@ucl.ac.uk
Falasca
M
M
D000818:Animals; D001808:Blood Vessels / Q000502:physiology; D004789:Enzyme Activation; D007700:Kinetics; D008563:Membrane Lipids / Q000378:metabolism; D019869:Phosphatidylinositol 3-Kinases / Q000502:physiology*; D051966:Phospholipase C gamma / Q000378:metabolism*; D010743:Phospholipids / Q000378:metabolism; D015290:Second Messenger Systems; D014680:Veins
D008563:Membrane Lipids; D010743:Phospholipids; D019869:Phosphatidylinositol 3-Kinases; D051966:Phospholipase C gamma