General synthesis and aggregation behaviour of a series of single-chain 1,omega-bis(phosphocholines).
The synthesis and physicochemical characterisation of a series of polymethylene-1,omega-bis(phosphocholines) with even-numbered chain lengths between 22 and 32 carbon atoms is described. Two new synthetic strategies for the preparation of long-chain 1,omega-diols as hydrocarbon building blocks are presented. The temperature-dependent self-assembly of the single-chain bolaamphiphiles was investigated by cryo transmission electron microscopy (cryo-TEM), differential scanning calorimetry (DSC), and Fourier transform infrared spectroscopy (FTIR).
Drescher
Simon
S
Institute of Pharmacy, MLU Halle-Wittenberg, Wolfgang-Langenbeck-Strasse 4, 06120 Halle/Saale, Germany.
Meister
Annette
A
Blume
Alfred
A
Karlsson
Göran
G
Almgren
Mats
M
Dobner
Bodo
B
D000438:Alcohols / Q000737:chemistry; D002152:Calorimetry, Differential Scanning; D002244:Carbon / Q000737:chemistry; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D008956:Models, Chemical; D010767:Phosphorylcholine / Q000031:analogs & derivatives / Q000138:chemical synthesis*; D012997:Solvents / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D013696:Temperature
D000438:Alcohols; D012997:Solvents; D010767:Phosphorylcholine; D002244:Carbon