Acute and chronic dosing of Lepidium meyenii (Maca) on male rat sexual behavior.
BACKGROUND
The use of natural remedies for the treatment of sexual disorders is under current investigation. For generations people of the rural community in Peru have used Lepidium meyenii Walpers (Maca), because of their belief that it improves fertility and sexual desire.


OBJECTIVE
To determine the acute and chronic effects of Maca on male sexual behavior and to examine chronic administration of Maca on anxiety.


METHODS
Ejaculatory and mounting behavior and postejaculatory interval. Anxiety tests using an elevated plus maze, locomotion, and social interaction with another male.


METHODS
Maca (25 and 100 mg/kg) was orally administered to male rats for 30 days. Male sexual behavior was monitored after acute, 7 and 21 days of treatment. Anxiety behavior and locomotion were measured at 28-29 days using the elevated plus maze and social interaction tests.


RESULTS
Maca treatment did not produce large changes in male sexual behavior. However, an increase in ejaculation latency and postejaculatory interval was observed after both acute and 7 days of treatment. After 21 days of treatment Maca had no effect on sexual behavior. Chronic administration of Maca did not increase locomotion or anxiety.


CONCLUSIONS
Acute and short-term administration of Maca produced a small effect of rat male sexual behavior and long-term administration did not increase anxiety.
Lentz
Aaron
A
Division of Urology, Department of Surgery, University of North Carolina, Chapel Hill, NC, USA.
Gravitt
Karla
K
Carson
Culley C
CC
Marson
Lesley
L
D000284:Administration, Oral; D000818:Animals; D004305:Dose-Response Relationship, Drug; D029686:Lepidium; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012726:Sexual Behavior, Animal / Q000187:drug effects*; D013737:Testis / Q000187:drug effects*
D010936:Plant Extracts