A new triterpene with antinociceptive activity from Maytenus robusta.
A new triterpene 3,15-dioxo-21alpha-hydroxy friedelane has been isolated from methanol extract of Maytenus robusta and its structure elucidated on the basis of spectral analysis. Stigmasterol, friedelin, friedelanol and 3,15-dioxo friedelane were also obtained. 3,15-dioxo-21alpha-hydroxy friedelane was analyzed against the writhing test in mice and exhibited potent dose-dependent effects with an ID50 value of 12.5 +/- 2.1 micromol kg(-1) and a maximal inhibition of 85.90%. It was about 10-fold more active than aspirin and paracetamol, used as reference drugs.
Niero
Rivaldo
R
Núcleo de Investigações Quimico-Farmacêuticas (NIQFAR)/CCS, Universidade do Vale do Itajaí (UNIVALI), 88.302-202 Itajaí, SC, Brazil. niero@univali.br
Mafra
Ana P
AP
Lenzi
Ana C
AC
Cechinel-Filho
Valdir
V
Tischer
Cesar A
CA
Malheiros
Angela
A
De Souza
Marcia M
MM
Yunes
Rosendo A
RA
Delle Monache
Franco
F
D000700:Analgesics / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D001938:Brazil; D008297:Male; D029755:Maytenus / Q000737:chemistry*; D051379:Mice; D019906:Nuclear Magnetic Resonance, Biomolecular; D009904:Optical Rotation; D010146:Pain / Q000188:drug therapy; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*
D000700:Analgesics; D010936:Plant Extracts; D014315:Triterpenes