Novel neurohormonal antagonist strategies: vasopressin antagonism, anticytokine therapy, and endothelin antagonism in patients who have heart failure.
Hedrich
Olaf
O
Tufts-New England Medical Center and Tufts University School of Medicine, Boston, MA 02111, USA.
Finley
John
J
Konstam
Marvin A
MA
Udelson
James E
JE
D065092:Antidiuretic Hormone Receptor Antagonists; D016207:Cytokines / Q000187:drug effects / Q000378:metabolism; D004341:Drug Evaluation; D065128:Endothelin Receptor Antagonists; D016232:Endothelins / Q000187:drug effects / Q000378:metabolism; D006333:Heart Failure / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use; D015850:Interleukin-6 / Q000378:metabolism; D018377:Neurotransmitter Agents / Q000037:antagonists & inhibitors*; D018121:Receptors, Cytokine / Q000037:antagonists & inhibitors* / Q000187:drug effects / Q000378:metabolism; D017466:Receptors, Endothelin / Q000187:drug effects / Q000378:metabolism; D017483:Receptors, Vasopressin / Q000187:drug effects / Q000378:metabolism; D016896:Treatment Outcome; D014409:Tumor Necrosis Factor-alpha / Q000187:drug effects / Q000378:metabolism; D014667:Vasopressins / Q000187:drug effects / Q000378:metabolism
D065092:Antidiuretic Hormone Receptor Antagonists; D016207:Cytokines; D065128:Endothelin Receptor Antagonists; D016232:Endothelins; D007155:Immunologic Factors; D015850:Interleukin-6; D018377:Neurotransmitter Agents; D018121:Receptors, Cytokine; D017466:Receptors, Endothelin; D017483:Receptors, Vasopressin; D014409:Tumor Necrosis Factor-alpha; D014667:Vasopressins