Aiolos: an ungrateful member of the Ikaros family.
Ikaros family members play an important role in hematopoietic development. Thompson et al. (2007) show that pre-BCR signaling induces Aiolos expression, which in turn suppresses the expression of the pre-BCR component lambda5 and eliminates the very structure that signaled its appearance.
Kioussis
Dimitris
D
Division of Molecular Immunology, Medical Research Council National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK. dkiouss@nimr.mrc.ac.uk
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D051740:Ikaros Transcription Factor / Q000502:physiology*; D008213:Lymphocyte Activation / Q000235:genetics*; D051379:Mice; D015534:Trans-Activators / Q000235:genetics*
C491396:Ikzf3 protein, mouse; D015534:Trans-Activators; D051740:Ikaros Transcription Factor