The influence of a PHI-5-loaded silicone membrane, on cutaneous wound healing in vivo.
This study investigated whether a novel ionogenic substance, containing amongst others zinc and rubidium (PHI-5; Dermagenics Inc, Memphis, TN, USA), could improve the healing of full-thickness skin wounds. Uniform wounds were created on the right flank of guinea pigs. Micro-grooved silicone rubber membranes, containing 0 (controls), 1.25, 5.00, or 10.00 microg PHI-5, were sutured onto this wound. Standardized digital wound photographs were made after 1, 3, and 6 weeks. Also, wound biopsies were taken after 3 and 6 weeks for histological and histomorphometrical evaluation. For all study groups, 6 animals were used. Analysis of the 1-week digital photographs showed that the surface area of the wounds decreased significantly, with an increasing PHI-5 concentration. No other differences were found in the wound photographs. Also, no differences were measured in histomorphometry at 3 and 6 weeks. Concluding, in our study model a single application of PHI-5 did have a significant positive influence on initial wound healing.
van Rossum
M
M
Department of Periodontology and Biomaterials, Radboud University Nijmegen Medical Centre, THK 309 PB, P. O. Box 9101, 6500 HB Nijmegen, The Netherlands.
Vooijs
D P P
DP
Walboomers
X F
XF
Hoekstra
M J
MJ
Spauwen
P H M
PH
Jansen
J A
JA
D000818:Animals; D047070:Bandages, Hydrocolloid; D004337:Drug Carriers / Q000737:chemistry; D006168:Guinea Pigs; D008297:Male; D012413:Rubidium / Q000008:administration & dosage* / Q000737:chemistry; D012828:Silicones / Q000737:chemistry*; D012867:Skin / Q000187:drug effects* / Q000293:injuries* / Q000473:pathology; D017768:Skin, Artificial; D014945:Wound Healing / Q000187:drug effects*; D014950:Wounds, Penetrating / Q000473:pathology* / Q000628:therapy*; D015032:Zinc / Q000008:administration & dosage* / Q000737:chemistry
D004337:Drug Carriers; C523779:PHI-5 formulation; D012828:Silicones; D015032:Zinc; D012413:Rubidium