title: Cytokeratin and filaggrin expression in nevus comedonicus.
abstract: To elucidate the pathogenesis of abnormal keratinization in nevus comedonicus, we performed an immunohistochemical study using antikeratin and antifilaggrin (filament-aggregating protein) antibodies. There were no significant differences between nevus comedonicus and normal skin in cytokeratin expression. Although filaggrin was only detected in the granular layer in open comedones, filaggrin was detected in both superficial cells and also intermediate cells in closed comedones, suggesting that filaggrin is involved in the formation of closed comedones. The disorder of terminal differentiation related to filaggrin may play a role in the pathogenesis of abnormal keratinization in nevus comedonicus.
authors: Department of Dermatology, Mie University Graduate School of Medicine, Mie, Japan. kuroichi@clin.medic.mie-u.ac.jp
authors: Ichiro
authors: I
authors: Kurokawa
authors: Yasuo
authors: Y
authors: Nakai
authors: Keisuke
authors: K
authors: Nishimura
authors: Arata
authors: A
authors: Hakamada
authors: Ken-ichi
authors: K
authors: Isoda
authors: Kei-ichi
authors: K
authors: Yamanaka
authors: Hitoshi
authors: H
authors: Mizutani
authors: Airo
authors: A
authors: Tsubura
mesh_terms: D000328:Adult; D000091344:Filaggrin Proteins; D006201:Hair Diseases / Q000378:metabolism / Q000473:pathology; D018859:Hair Follicle / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D007381:Intermediate Filament Proteins / Q000096:biosynthesis*; D007633:Keratins / Q000096:biosynthesis*; D008297:Male; D012625:Sebaceous Gland Diseases / Q000378:metabolism / Q000473:pathology*
chemical_list: C000717249:FLG protein, human; D000091344:Filaggrin Proteins; D007381:Intermediate Filament Proteins; D007633:Keratins