Chlorpyrifos increases the levels of hippocampal NMDA receptor subunits NR2A and NR2B in juvenile and adult rats.
The present study investigated the effect of chlorpyrifos on NMDA receptor subunits NR2A and NR2B in juvenile and adult rats. Chlorpyrifos was administered with the dose of 40 and 70 mg/kg to juvenile and adult rats, respectively. Chlorpyrifos significantly inhibited the AChE activity in juvenile and adult rats (p < .05). NR2A and NR2B levels significantly increased in juvenile and adult rats by chlorpyrifos application (p < .05). Increased NR2A and NR2B levels may reflect increased glutaminergic activity, consequently neuronal damage. In the case of neuronal damage, learning and memory could be affected negatively even though NR2A and NR2B increased.
Gultekin
Fatih
F
Suleyman Demirel University, School of Medicine, Department of Biochemistry, Isparta, Turkey. fatih@sdu.edu.tr
Karakoyun
Inanc
I
Sutcu
Recep
R
Savik
Emin
E
Cesur
Gokhan
G
Orhan
Hikmet
H
Delibas
Namik
N
D000110:Acetylcholinesterase / Q000097:blood / Q000187:drug effects* / Q000378:metabolism; D000367:Age Factors; D000818:Animals; D004390:Chlorpyrifos / Q000633:toxicity*; D002800:Cholinesterase Inhibitors / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism; D007306:Insecticides / Q000633:toxicity*; D008297:Male; D021122:Protein Subunits; D051381:Rats; D017207:Rats, Sprague-Dawley; D016194:Receptors, N-Methyl-D-Aspartate / Q000187:drug effects* / Q000378:metabolism; D018709:Statistics, Nonparametric
D002800:Cholinesterase Inhibitors; D007306:Insecticides; C120997:NR2A NMDA receptor; C121001:NR2B NMDA receptor; D021122:Protein Subunits; D016194:Receptors, N-Methyl-D-Aspartate; D000110:Acetylcholinesterase; D004390:Chlorpyrifos