title: The macrophage migration inhibitory factor-glucocorticoid dyad: regulation of inflammation and immunity.
abstract: The cytokine macrophage migration inhibitory factor (MIF) occupies a unique position in physiology by its ability to directly regulate the immunosuppressive actions of glucocorticoids. We review herein the interactions between MIF and glucocorticoids within the immune system and discuss the relevance of the MIF-glucocorticoid regulatory dyad in physiology and immunopathology. Therapeutic antagonism of MIF may be an effective approach for steroid-sparing therapies in patients with refractory autoimmune or inflammatory diseases.
authors: Yale University School of Medicine, New Haven, Connecticut 06520, USA.
authors: Harry
authors: H
authors: Flaster
authors: Jürgen
authors: J
authors: Bernhagen
authors: Thierry
authors: T
authors: Calandra
authors: Richard
authors: R
authors: Bucala
mesh_terms: D001327:Autoimmune Diseases / Q000628:therapy; D005938:Glucocorticoids / Q000378:metabolism*; D006801:Humans; D007107:Immune System / Q000378:metabolism*; D007109:Immunity; D007165:Immunosuppression Therapy; D007249:Inflammation / Q000276:immunology*; D008263:Macrophage Migration-Inhibitory Factors / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D008264:Macrophages / Q000276:immunology
chemical_list: D005938:Glucocorticoids; D008263:Macrophage Migration-Inhibitory Factors