[Selank-induced normalizing effects on the integrative brain activity and biogenic amine level disorders due to antenatal hypoxia].
The effects of Selank synthetic analog of Tuftsin, representing the heptapeptide forming Thr-Lys-Pro-Arg-Pro-Gly-Pro, on behavior and serotonin/noradrenalin concentrations in brain were investigated in adult rats exposed to hypoxia during 14-16 days of gestation. It was revealed that injection of Selank (300 mkg/kg, i/p) increased 2--3-fold (p < 0.01) the sensory attention, facilitated 1.5-fold the learning capacity (p < 0.01), normalized exploratory activity in the open field and hole board, and recovered the balance of serotonergic and noradrenergic brain system activity. The data obtained demonstrate the possibility of Selank to compensate for long-lasting negative effects of antenatal hypoxia on integrative brain activity and brain monoamine level.
Semenova
T P
TP
Institute of Cell Biophysics, Russian Acad. Sci., Pushchino, Moscow District, Russia.
Kozlovskaia
M M
MM
Zuĭkov
A V
AV
Kozlovskiĭ
I I
II
Zakharova
N M
NM
Andreeva
L A
LA
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D015306:Biogenic Monoamines / Q000378:metabolism*; D001921:Brain / Q000378:metabolism*; D001923:Brain Chemistry / Q000187:drug effects; D005106:Exploratory Behavior / Q000187:drug effects; D005260:Female; D002534:Hypoxia, Brain / Q000378:metabolism*; D008297:Male; D009842:Oligopeptides / Q000494:pharmacology*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000188:drug therapy* / Q000378:metabolism*; D051381:Rats; D020127:Recovery of Function / Q000187:drug effects
D015306:Biogenic Monoamines; D009842:Oligopeptides; C100827:TP 7