[Indocyanine green and fluorescein angiography study of glaucomatous peripapillary atrophy].
OBJECTIVE
To investigate the incidence of glaucomatous peripapillary atrophy (PPA) and choroidal circulation of glaucomatous patients.


METHODS
The subjects of glaucoma groups included 43 (43 eyes) glaucomatous patients including 16 (16 eyes) chronic angle-closure glaucoma (CACG), 27 (27 eyes) open-angle glaucoma. Control group included 33 (33 eyes) cases. Indocyanine green angiography and fundus fluorescein angiography were performed on glaucoma groups and control group with Heidelberg retinal angiography (HRA) to observe alpha zone and beta zone of PPA.


RESULTS
The frequency of beta zone in CACG, open-angle glaucoma and control group was 31.3%, 77.8% and 21.9%, respectively, with statistically significant difference between these groups (chi(2) = 19.915, P = 0.000). Beta zone showed ICG hypofluorescence in all eyes. There were no statistically significant difference in the frequency of alpha zone between glaucoma groups and control group. However, there were two different types of indocyanine green filling in alpha zone: normal or decreased choroid filling. Decreased choroid filling in alpha zone was observed in 53.8% of eyes with chronic angle-closure glaucoma, 66.7% of open-angle glaucoma and 32.1% of in control, the difference was significant (chi(2) = 6.648, P = 0.036).


CONCLUSIONS
The frequency of zone beta with no choroidal filling in open-angle glaucoma group is the highest among these three groups. Zone alpha in glaucomatous eyes show decreased choroidal circulation, which may be the early sign for the extension of beta zone.
Wu
Ling-ling
LL
Peking University Third Hospital, Peking University Eye Center, Beijing 100083, China. wllc@mail.hz.zj.cn
Chen
Wei
W
Chen
Zhi-qing
ZQ
Yin
Jin-fu
JF
Zhou
Hui
H
Liu
Jing
J
Su
Zhao-an
ZA
D000328:Adult; D000368:Aged; D001284:Atrophy; D016022:Case-Control Studies; D002829:Choroid / Q000000981:diagnostic imaging*; D005260:Female; D005451:Fluorescein Angiography; D005901:Glaucoma / Q000000981:diagnostic imaging*; D006801:Humans; D007208:Indocyanine Green; D008297:Male; D008875:Middle Aged; D011859:Radiography; D012160:Retina / Q000000981:diagnostic imaging*
D007208:Indocyanine Green