title: Dose dependence of mass and microcalcification detection in digital mammography: free response human observer studies.
abstract: The purpose of this study was to evaluate the effect of dose reduction in digital mammography on the detection of two lesion types-malignant masses and clusters of microcalcifications. Two free-response observer studies were performed-one for each lesion type. Ninety screening images were retrospectively selected; each image was originally acquired under automatic exposure conditions, corresponding to an average glandular dose of 1.3 mGy for a standard breast (50 mm compressed breast thickness with 50% glandularity). For each study, one to three simulated lesions were added to each of 40 images (abnormals) while 50 were kept without lesions (normals). Two levels of simulated system noise were added to the images yielding two new image sets, corresponding to simulated dose levels of 50% and 30% of the original images (100%). The manufacturer's standard display processing was subsequently applied to all images. Four radiologists experienced in mammography evaluated the images by searching for lesions and marking and assigning confidence levels to suspicious regions. The search data were analyzed using jackknife free-response (JA-FROC) methodology. For the detection of masses, the mean figure-of-merit (FOM) averaged over all readers was 0.74, 0.71, and 0.68 corresponding to dose levels of 100%, 50%, and 30%, respectively. These values were not statistically different from each other (F= 1.67, p=0.19) but showed a decreasing trend. In contrast, in the microcalcification study the mean FOM was 0.93, 0.67, and 0.38 for the same dose levels and these values were all significantly different from each other (F = 109.84, p < 0.0001). The results indicate that lowering the present dose level by a factor of two compromised the detection of microcalcifications but had a weaker effect on mass detection.
authors: Department of Medical Radiation Physics, Lund University, Malmö University Hospital, SE-205 02, Malmö, Sweden.
authors: Mark
authors: M
authors: Ruschin
authors: Pontus
authors: P
authors: Timberg
authors: Magnus
authors: M
authors: Båth
authors: Bengt
authors: B
authors: Hemdal
authors: Tony
authors: T
authors: Svahn
authors: Rob S
authors: RS
authors: Saunders
authors: Ehsan
authors: E
authors: Samei
authors: Ingvar
authors: I
authors: Andersson
authors: Soren
authors: S
authors: Mattsson
authors: Dev P
authors: DP
authors: Chakrabort
authors: Anders
authors: A
authors: Tingber
mesh_terms: D001943:Breast Neoplasms / Q000000981:diagnostic imaging*; D002114:Calcinosis / Q000000981:diagnostic imaging*; D004307:Dose-Response Relationship, Radiation; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008327:Mammography / Q000379:methods*; D015588:Observer Variation; D011230:Precancerous Conditions / Q000000981:diagnostic imaging*; D011829:Radiation Dosage; D011856:Radiographic Image Enhancement / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity