title: Effects of gentian violet on refractory discharging ears infected with methicillin-resistant Staphylococcus aureus.
abstract: OBJECTIVE
  To test the efficacy of topical treatment with gentian violet on methicillin-resistant Staphylococcus aureus (MRSA).
  
  
  METHODS
  Retrospective study.
  
  
  METHODS
  Territorial referral centre.
  
  
  METHODS
  Patients with discharging ears infected with MRSA alone or MRSA and Pseudomonas aeruginosa (PA).
  
  
  METHODS
  One percent gentian violet was applied.
  
  
  RESULTS
  Remission of discharge.
  
  
  RESULTS
  Remission was obtained in 44 of 46 ears infected with MRSA, whereas remission was obtained in only 3 of 6 ears infected with MRSA and PA. The minimum inhibitory concentrations (MICs) of gentian violet for MRSA strains sensitive to topical application of gentian violet and strains resistant to this treatment were 0.03 microg/mL and 0.5%, respectively. The MIC for PA resistant to topical gentian violet treatment was higher than 32 microg/mL.
  
  
  CONCLUSIONS
  Topical application of gentian violet is a useful option for the treatment of refractory discharging ears infected with MRSA. However, great care must be taken if there is any chance of the gentian violet reaching the middle ear.
authors: Department of Otolaryngology, Konan General Hospital, Kobe, Japan.
authors: Chikako
authors: C
authors: Kayama
authors: Yukako
authors: Y
authors: Goto
authors: Satoko
authors: S
authors: Shimoya
authors: Shingo
authors: S
authors: Hasegawa
authors: Shin-ichi
authors: S
authors: Murao
authors: Yoshimi
authors: Y
authors: Nakajo
authors: Ken-ichi
authors: K
authors: Nibu
mesh_terms: D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage*; D002648:Child; D002675:Child, Preschool; D004427:Ear Diseases / Q000188:drug therapy* / Q000382:microbiology; D005840:Gentian Violet / Q000008:administration & dosage*; D006801:Humans; D007223:Infant; D016106:Methicillin Resistance; D008875:Middle Aged; D011552:Pseudomonas Infections / Q000188:drug therapy; D012189:Retrospective Studies; D013203:Staphylococcal Infections / Q000188:drug therapy*; D013211:Staphylococcus aureus; D016896:Treatment Outcome
chemical_list: D000891:Anti-Infective Agents, Local; D005840:Gentian Violet