[Bronchi reaction to the inhaled salbutamol according to the polymorphisms of beta2-adrenergic receptor].
BACKGROUND
The functioning of beta2-adrenergic receptor (beta2ADR) depends on its isoforms. Polymorphism of the beta2ADR gene has been described, the most frequent being g.46A --> G and g.79C --> G. The reaction of the bronchi to inhaled salbutamol has now been studied in relation to g.46A --> 4G and g.79C --> G polymorphisms. For this purpose, spirometry was done in healthy males aged 20-26 years.


METHODS
The study group comprised 170 young men who were allocated to six groups according to the beta2ADR genotype determined with PCR: g.46A --> G polymorphism (g.46AA, g.46GG, g.46AG), g.79C --> G polymorphism (g.79CC, g.79GG, g.79GC). Spirometric parameters were measured before and after inhalation of salbutamol. The results of the test were compared in g.46A --> G groups and g.79C --> G groups.


RESULTS
Administration of 200 microg of salbutamol significantly increased spirometrc parameters during forced expiration. However, changes were not specific for any genotype. Increase in PEF was significantly higher in g.46AA than g.46GG and in g.79CC than g.79GC genotypes. The distribution of genotypes was typical for the Caucasian population.
Poziomkowska-Gesicka
Iwona
I
Katedra i Zakład Fizjologii, Pomorskiej Akademii Medycznej, al. Powstańców Wlkp. 72, 70-111 Szczecin.
D000280:Administration, Inhalation; D000328:Adult; D000420:Albuterol / Q000008:administration & dosage; D001980:Bronchi / Q000187:drug effects* / Q000502:physiology*; D005838:Genotype; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D012123:Pulmonary Ventilation / Q000187:drug effects / Q000235:genetics*; D018343:Receptors, Adrenergic, beta-2 / Q000737:chemistry* / Q000187:drug effects; D012129:Respiratory Function Tests; D013147:Spirometry
D018343:Receptors, Adrenergic, beta-2; D000420:Albuterol