title: Recent advances and current challenges in tumor immunology and immunotherapy.
abstract: Despite advances in animal studies, where the cure of the majority of mice with pre-established (albeit early-stage) tumors has become almost standard, human clinical trials have been much less successful. Here we describe some of the most recent advances in the specialist field of tumor immunology and immunotherapy, highlighting salient work to identify key problem areas and potential solutions. We make particular note of recent developments in adoptive therapy; whole-cell, DNA, and peptide vaccines; and antibody therapy. We also describe the revival of interest in regulatory T cells and conclude by detailing the need for clinical trial read-out autonomy and methods to predict which patients will respond to a particular treatment.
authors: Department of Haematological Medicine, King's College London School of Medicine, The Rayne, Institute, London, UK. barbara.guinn@kcl.ac.uk
authors: Barbara-ann
authors: BA
authors: Guinn
authors: Noriyuki
authors: N
authors: Kasahara
authors: Farzin
authors: F
authors: Farzaneh
authors: Nagy A
authors: NA
authors: Habib
authors: James S
authors: JS
authors: Norris
authors: Albert B
authors: AB
authors: Deisseroth
mesh_terms: D000818:Animals; D019496:Cancer Vaccines / Q000276:immunology; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D016219:Immunotherapy, Adoptive / Q000379:methods; D009369:Neoplasms / Q000276:immunology / Q000628:therapy*; D014611:Vaccination / Q000379:methods
chemical_list: D019496:Cancer Vaccines