title: Synthesis and biological evaluation of 12 allenic aromatic ethers.
abstract: Twelve allenic aromatic ethers, some of them are natural products isolated from the mangrove fungus Xylaria sp. 2508 in the South China Sea, were synthesized. Their antitumor activities against KB and KBv200 cells were determined. All these compounds demonstrated cytotoxic potential, ranging from weak to strong activity. The analysis of structure-activity relationships suggested that the introduction of allenic moiety could generate or enhance cytotoxicity of these phenol compounds.
authors: School of Chemistry and Chemical Engineering, Sun Yat-Sen(Zhongshan) University, Guangzhou 510275, China.
authors: San-Yong
authors: SY
authors: Wang
authors: Wei-Wei
authors: WW
authors: Mao
authors: Zhi-Gang
authors: ZG
authors: She
authors: Chun-Rong
authors: CR
authors: Li
authors: Ding-Qiao
authors: DQ
authors: Yang
authors: Yong-Cheng
authors: YC
authors: Lin
authors: Li-Wu
authors: LW
authors: Fu
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D002681:China; D004354:Drug Screening Assays, Antitumor; D004986:Ether / Q000737:chemistry / Q000494:pharmacology*; D004987:Ethers / Q000737:chemistry / Q000494:pharmacology; D005069:Evaluation Studies as Topic; D006801:Humans; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D004987:Ethers; D004986:Ether