title: [Chromosomal alterations analyzed by comparative genomic hybridization in primary gastric carcinoma].
abstract: OBJECTIVE
  To identify genetic abnormalities in primary gastric carcinoma.
  
  
  METHODS
  Comparative genomic hybridization (CGH) was used in screening DNA copy number changes along all chromosomes in 23 cases of primary gastric cancer.
  
  
  RESULTS
  Twenty-one out of 23 cases showed chromosomal losses and gains for at least one of the chromosomal arms in primary gastric cancer. The mean number of chromosomal alterations was 7.52. Chromosomal gains predominated over chromosomal losses in a ratio of 5.38:2.14. The most often involved chromosomal gains were observed in 8q (9/21, 42.9%), 20q (9/21, 42.9%), 17q (8/21, 38.1%), 3q (7/21, 33.3%), 7q (7/21, 33.3%), 11q (6/21, 28.6%), 13q (6/21, 28.6%), 1q (5/21, 23.8%) and 20p (5/21, 23.8%). The chromosomal arms with frequent losses were 17p (7/21, 33.3%), 18q (6/21, 28.6%), 5q (5/21, 23.8%), 8p (5/21, 23.8%), and 9p (5/21, 23.8%).
  
  
  CONCLUSIONS
  The phenomenon of gain and loss of chromosomal regions is observed in primary gastric cancer, which may induce the amplification of oncogenes and the loss of tumor suppressor genes to regulate the development and progression of gastric cancer.
authors: Department of Surgery, Shanghai Institute of Digestive Surgery, Ruijin Hospital, Medical College of Shanghai Jiaotong University, Shanghai 200025, China. liubyrj@yahoo.com.cn
authors: Ya-qing
authors: YQ
authors: Zhu
authors: Zheng-gang
authors: ZG
authors: Zhu
authors: Bing-ya
authors: BY
authors: Liu
authors: Xue-hua
authors: XH
authors: Chen
authors: Hao-ran
authors: HR
authors: Yin
authors: Xue-hao
authors: XH
authors: Wang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002869:Chromosome Aberrations; D002872:Chromosome Deletion; D055028:Comparative Genomic Hybridization; D004247:DNA; D005260:Female; D020869:Gene Expression Profiling; D016147:Genes, Tumor Suppressor; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D013274:Stomach Neoplasms / Q000235:genetics* / Q000473:pathology
chemical_list: D004247:DNA