title: Early-onset sarcoidosis mimicking refractory cutaneous histiocytosis.
abstract: A 10-year-old female was diagnosed as having early-onset sarcoidosis (EOS) after a prolonged skin disease. A granuloma emerged on the face at age 2 and massive lesions extended to the rest of the body. Repeated biopsies indicated histiocytic proliferation. At age 7, fever, disseminated macular eruptions, and multinucleated giant cells in the bone marrow prompted vinblastine and prednisolone therapy. Five months after stopping therapy, hypercalcemic crisis occurred along with fever, cytopenias, and interferon-gamma-nemia indicating a macrophage activation syndrome. A biopsy of nodules confirmed the diagnosis of sarcoidosis. The atypical EOS should be differentiated from histiocytosis.
authors: Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. ohgas@pediatr.med.kyushu-u.ac.jp
authors: Shouichi
authors: S
authors: Ohga
authors: Kiyomi
authors: K
authors: Ichino
authors: Kazunori
authors: K
authors: Urabe
authors: Masataka
authors: M
authors: Ishimura
authors: Hidetoshi
authors: H
authors: Takada
authors: Ryuta
authors: R
authors: Nishikomori
authors: Masutaka
authors: M
authors: Furue
authors: Toshiro
authors: T
authors: Hara
mesh_terms: D002648:Child; D003937:Diagnosis, Differential; D003951:Diagnostic Errors; D042241:Early Diagnosis; D005047:Etoposide / Q000627:therapeutic use; D005148:Facial Dermatoses / Q000209:etiology; D005260:Female; D015614:Histiocytosis / Q000175:diagnosis*; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology; D007371:Interferon-gamma / Q000097:blood; D007378:Interleukins / Q000097:blood; D008262:Macrophage Activation; D008727:Methotrexate / Q000627:therapeutic use; D011239:Prednisolone / Q000627:therapeutic use; D012507:Sarcoidosis / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D012871:Skin Diseases / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D014747:Vinblastine / Q000627:therapeutic use
chemical_list: D007378:Interleukins; D014747:Vinblastine; D005047:Etoposide; D007371:Interferon-gamma; D011239:Prednisolone; D008727:Methotrexate