title: Design of potent PPARalpha agonists.
abstract: Computational analysis of the ligand binding pocket of the three PPAR receptor subtypes was utilized in the design of potent PPARalpha agonists. Optimum PPARalpha potency and selectivity were obtained with substituents having van der Waals volume around 260. Compound 6 had a PPARalpha potency of 0.002 microM and a selectivity ratio to PPARgamma and PPARdelta of 410 and 2000, respectively.
authors: Novo Nordisk A/S, Novo Nordisk Park, 2760 Måløv, Denmark.
authors: Per
authors: P
authors: Sauerberg
authors: John P
authors: JP
authors: Mogensen
authors: Lone
authors: L
authors: Jeppesen
authors: Paul S
authors: PS
authors: Bury
authors: Jan
authors: J
authors: Fleckner
authors: Grith S
authors: GS
authors: Olsen
authors: Claus B
authors: CB
authors: Jeppesen
authors: Erik M
authors: EM
authors: Wulff
authors: Pavel
authors: P
authors: Pihera
authors: Miroslav
authors: M
authors: Havranek
authors: Zdenek
authors: Z
authors: Polivka
authors: Ingrid
authors: I
authors: Pettersson
mesh_terms: D000818:Animals; D003201:Computers; D003461:Crystallography; D015195:Drug Design; D008024:Ligands; D047493:PPAR alpha / Q000819:agonists* / Q000737:chemistry; D010666:Phenylpropionates / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D008024:Ligands; D047493:PPAR alpha; D010666:Phenylpropionates