title: [Musculoskeletal complications of Werner's syndrome].
abstract: BACKGROUND
  Werner's syndrome, a rare autosomal recessive genetic disease, is a premature aging disease characterized by early onset of symptoms related to normal aging including short stature, cataracts, graying of the hair, skin ulcerations, diabetes, osteoporosis, atherosclerosis and predisposition to cancer. Musculoskeletal complications can also develop with major impairment of quality of life for these patients.
  
  
  METHODS
  We report two typical cases in two males aged 47 and 44 diagnosed on the basis of cutaneous progeroid signs. Diagnosis was confirmed by identification of homozygotous mutations in the WRN gene. The first patient later developed chronic osteomyelitis of the right forearm, which is a rare complication of Werner's syndrome. The second patient presented calcaneum valgus resulting in mechanical overwork and bilateral posterior tibial tendinitis. He also developed osteitis of the 5th toe.
  
  
  CONCLUSIONS
  Dermatologists should be aware of the potential orthopedic complications of this disease in order to diagnose them as quickly as possible and organize multidisciplinary management alongside other specialists such as rheumatologists and orthopedic surgeons.
authors: Université Montpellier I, Service de Dermatologie, Hôpital Saint Eloi, CHU, Montpellier. nicolaskluger@yahoo.fr
authors: N
authors: N
authors: Kluger
authors: S
authors: S
authors: Aractingi
authors: P
authors: P
authors: Aboukrat
authors: I
authors: I
authors: Vanderlinden
authors: B
authors: B
authors: Guillot
authors: D
authors: D
authors: Bessis
mesh_terms: D000328:Adult; D006801:Humans; D007592:Joint Diseases / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009140:Musculoskeletal Diseases / Q000209:etiology*; D010000:Osteitis / Q000209:etiology; D010019:Osteomyelitis / Q000209:etiology; D052256:Tendinopathy / Q000209:etiology; D014898:Werner Syndrome / Q000150:complications*