Morphofunctional study of the therapeutic effect of autologous mesenchymal stem cells in experimental diffuse brain injury in rats.
Effects of systemic transplantation of mesenchymal stem cells obtained by culturing of autologous bone marrow on proliferative activity of cells and functional morphology of neurons after diffuse brain injury were studied in Wistar rats. Comparative analysis of the results indicated that systemic injection of mesenchymal stem cells in a syngeneic organism produced proliferotropic, angiogenic, and, presumably, neurotrophic effects. The therapeutic effect visually manifested on day 2 after intravenous injection of mesenchymal stem cells during the early period of reparative regeneration of ischemic cell and tissue structures of the brain. The neuroprotective effect of mesenchymal stem cells was more pronounced against the background of basic therapy.
Tsyb
A F
AF
Medical Radiology Research Center, Russian Academy of Medical Sciences.
Roshal'
L M
LM
Yuzhakov
V V
VV
Konoplyannikov
A G
AG
Sushkevich
G N
GN
Bandurko
L N
LN
Ingel'
I E
IE
Semenova
Zh B
ZhB
Konoplyannikova
O A
OA
Lepekhina
L A
LA
Kal'sina
S Sh
SSh
Verkhovskii
Yu G
YG
Shevchuk
A S
AS
Semenkova
I V
IV
D000818:Animals; D001930:Brain Injuries / Q000473:pathology / Q000628:therapy*; D049109:Cell Proliferation; D006652:Histological Techniques; D007275:Injections, Intravenous; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods*; D018919:Neovascularization, Physiologic / Q000502:physiology; D009474:Neurons / Q000166:cytology*; D051381:Rats; D017208:Rats, Wistar; D014185:Transplantation, Isogeneic / Q000379:methods