title: [The features of pathology and immunohistochemistry in orbital meningiomas].
abstract: OBJECTIVE
  To study the biological characteristics of orbital meningiomas using histological and immunohistochemistrical analysis.
  
  
  METHODS
  19 specimens taking from orbital meningiomas were included in the study. HE staining was used for histology analysis and the immunohistochemistry was applied to demonstrate the expression of Vimentin, EMA, Ki-67, p53 in the tissue of orbital meningiomas.
  
  
  RESULTS
  The main configuration of orbital meningiomas was meningothelial, transitional and fibrous meningioma. The expression rations of Vimentin and EMA were 94.75% (18/19), 52.63% (10/19), respectively. The detected rations of Ki-67 and p53 were very lower.
  
  
  CONCLUSIONS
  Our study shows that the major histological configuration of orbital meningiomas are meningothelial, transitional and fibrous meningioma. Compare with intracranial meningiomas, the expression rate of EMA in orbital meningiomas is lower. No difference of the expression rates of p53 and Ki-67 are found in benignant, recrudescent and malignant of tumor.
authors: Institute of Orbital Disease, Armed Police General Hospital, Beijing 100039, China. heiyan842@yahoo.com.cn
authors: Yan
authors: Y
authors: Hei
authors: Xin-wu
authors: XW
authors: Zhang
authors: Yi
authors: Y
authors: Wang
authors: Xiao-zhong
authors: XZ
authors: Lu
authors: Xin-ji
authors: XJ
authors: Yang
authors: Li-hua
authors: LH
authors: Xiao
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D019394:Ki-67 Antigen / Q000378:metabolism; D008297:Male; D008579:Meningioma / Q000378:metabolism / Q000473:pathology*; D008875:Middle Aged; D018396:Mucin-1 / Q000378:metabolism; D009918:Orbital Neoplasms / Q000378:metabolism / Q000473:pathology*; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism; D014746:Vimentin / Q000378:metabolism; D055815:Young Adult
chemical_list: D019394:Ki-67 Antigen; D018396:Mucin-1; D016159:Tumor Suppressor Protein p53; D014746:Vimentin