Essential role of placental leucine aminopeptidase in gynecologic malignancy.
The M1 aminopeptidase family is important for the maturation or degradation of bioactive peptides by hydrolyzing their N-terminal amino acids. Some investigators have studied aminopeptidase in the maintenance of homeostasis including maintenance of normal pregnancy, memory retention, blood pressure regulation and antigen presentation. However, there are a few reports on the relation between the M1 aminopeptidase family and carcinoma. In addition to its capacity to degrade a range of peptides, placental-leucine aminopeptidase (P-LAP) has novel functions that impact on normal cells and neoplastic cells. P-LAP is the focus of this review.
Mizutani
Shigehiko
S
Nagoya University School of Medicine, Department of Medical Science of Proteases, Nagoya, Japan.
Shibata
Kiyosumi
K
Kikkawa
Fumitaka
F
Hattori
Akira
A
Tsujimoto
Masafumi
M
Ishii
Masakazu
M
Kobayashi
Hiroshi
H
D000818:Animals; D010122:Cystinyl Aminopeptidase / Q000145:classification / Q000378:metabolism*; D005260:Female; D005833:Genital Neoplasms, Female / Q000201:enzymology* / Q000473:pathology; D006801:Humans; D010121:Oxytocin / Q000378:metabolism; D018045:Receptors, Oxytocin / Q000378:metabolism
D018045:Receptors, Oxytocin; D010121:Oxytocin; D010122:Cystinyl Aminopeptidase; C105964:leucyl-cystinyl aminopeptidase