A new perspective in diagnosing polycystic ovary syndrome.
Recently, the term of "possible" polycystic ovary syndrome (PCOS) has been used for defining cases in which biochemical evaluations are incomplete but clinical phenotypes are suggestive of PCOS. The aim of this study was, by using Rotterdam 2003 criteria, to detect possible PCOS cases and compare their characteristics and insulin sensitivity status with confirmed PCOS subjects. One-hundred-eighteen women who admitted with complaints and symptoms suggesting PCOS were included. Insulin sensitivity status of the cases was calculated with Homeostasis Model Assessment of Insulin Resistance (HOMA-IR). Cases fulfilling Rotterdam 2003 criteria were defined as confirmed PCOS, whereas indeterminate subjects as possible PCOS. Confirmed PCOS was detected in 70 (59.3%) and possible PCOS in 48 (40.7%) cases. Confirmed PCOS was most prevalent among subjects with hirsutism and menstrual dysfunction; 32 (80.0%) vs. 8 (20%), (p=0.000). Body mass index and HOMA-IR values did not differ between groups: confirmed PCOS versus possible PCOS; 25.46+/-5.55 kg/m(2) vs. 26.75+/-7.55 kg/m(2), 3.37+/-4.12 vs. 3.21+/-2.50, (p>0.05). Family history of type-2 diabetes mellifus was similar within both groups (p>0.05). Many PCOS patients seem to be undiagnosed due to inadherence to diagnostic work-up and/or to not fulfill Rotterdam 2003 criteria. These criteria may not be sufficient to cover the entire spectrum of PCOS.
Ertorer
Melek Eda
ME
Division of Endocrinology and Metabolism, Baskent University, Faculty of Medicine, Ankara, Turkey. e_ertorer@yahoo.com
Anaforoglu
Inan
I
Bozkirli
Emre
E
Bakiner
Okan
O
Tutuncu
Neslihan Bascil
NB
Demirag
Nilgun Guvener
NG
D015992:Body Mass Index; D003937:Diagnosis, Differential; D005260:Female; D006628:Hirsutism; D006801:Humans; D007333:Insulin Resistance; D008599:Menstruation Disturbances; D011085:Polycystic Ovary Syndrome / Q000175:diagnosis* / Q000473:pathology; D012307:Risk Factors