Compatibility of topical therapies for psoriasis: challenges and innovations.
Topical treatments remain the most widely prescribed medications for psoriasis, particularly for patients with mild to moderate or localized disease. In addition, topical therapies can substantially improve outcomes when used alone or in combination with systemic or biologic agents in patients with moderate to severe or more extensive disease. Combinations of different topical treatments frequently are prescribed to enhance clinical effectiveness and decrease potential side effects. However, certain topical agents become ineffective when used together or in combination with other therapies, such as phototherapy. These topical agents should be combined only with treatments that have been demonstrated to have no effect on the chemical stability or clinical effectiveness of topical agents. This article reviews the compatibility of different topical agents and identifies those agents that can be effectively and safely combined with each other and with phototherapy.
Lebwohl
Mark G
MG
Department of Dermatology, Mount Sinai School of Medicine, New York, New York, USA.
Corvari
Linda
L
D000287:Administration, Topical; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D006801:Humans; D011565:Psoriasis / Q000188:drug therapy*; D014467:Ultraviolet Therapy