title: Metal-containing proteins in the apoptosis and redox processes in the rat prostate and human prostate cells.
abstract: Several trace elements, such as Se, Cu, Mn, and Zn are bound to proteins (metallo- and metalloidproteins) in the prostate gland. Currently, it is known that some of those elements play a role in the apoptosis of different cells and redox processes. For the detection of such proteins, analytical and biochemical procedures were combined. SEC and ICP-MS were used to detect some trace elements, which are bound to proteins in the prostate cytosol and/or in the human prostate cell lines. Several antibodies against specific proteins were tested. By means of some of these antibodies several trace element-containing proteins, such as selenoproteins and Cu- and Cu-Zn-proteins, could be identified in the prostate. In addition, the localization of such metal- and metalloid-containing proteins in the micro organelles and cytosol of the prostate indicates specific functions of these proteins because, as it is known, such metal- and metalloid proteins play a role in the apoptosis and especially in the redox processes.
authors: Department for Molecular Trace Element Research in the Life Sciences, Hahn-Meitner-Institut, Glienicker Str. 100, 14109 Berlin, Germany. Grbavac@hmi.de
authors: I
authors: I
authors: Grbavac
authors: C
authors: C
authors: Wolf
authors: N
authors: N
authors: Wenda
authors: D
authors: D
authors: Alber
authors: M
authors: M
authors: Kühbacher
authors: D
authors: D
authors: Behne
authors: A
authors: A
authors: Kyriakopoulos
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D006801:Humans; D008297:Male; D008670:Metals / Q000032:analysis*; D010084:Oxidation-Reduction; D011467:Prostate / Q000166:cytology / Q000378:metabolism*; D011506:Proteins / Q000737:chemistry / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D008670:Metals; D011506:Proteins