Cytotoxic kurubasch aldehyde from Trichilia emetica.
Kurubasch aldehyde, a sesquiterpenoid with an hydroxylated humulene skeleton, was isolated as free alcohol from Trichilia emetica Vahl. (Meliaceae), belonging to the order Sapindales. Related substances have been previously found in plants as esters of aromatic acids, and these plants were species belonging to the distant order Apiales. This is the first report of humulenes found in the genus Trichilia and only the second of humulenes in the order Sapindales. The aldehyde is a modest inhibitor of the growth of Plasmodium falciparum (IC50 76 microM) and slow-proliferating breast cancer cells MCF7 (78 microM), but a potent inhibitor of proliferation of S180 cancer cells (IC50 7.4 microM).
Traore
Maminata
M
Direction Regionale de Institut de Recherche en Sciences de la Santé, Bobo-Dioulasso, Burkina Faso.
Zhai
Lin
L
Chen
Ming
M
Olsen
Carl Erik
CE
Odile
Nacoulma
N
Pierre
Guissou I
GI
Bosco
Ouédrago J
OJ
Robert
Guigemdé T
GT
Christensen
S Brøgger
SB
D000447:Aldehydes / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D006801:Humans; D013058:Mass Spectrometry; D029582:Meliaceae / Q000737:chemistry*; D051379:Mice; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009904:Optical Rotation; D018517:Plant Roots / Q000737:chemistry; D010963:Plasmodium falciparum / Q000187:drug effects; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D000447:Aldehydes; D000962:Antimalarials; D000972:Antineoplastic Agents, Phytogenic; D012717:Sesquiterpenes