Architecture of a microRNA-controlled gene regulatory network that diversifies neuronal cell fates.
Individual cell types are defined by the expression of specific gene batteries. Regulatory networks that control cell-type-specific gene expression programs in the nervous system are only beginning to be understood. This paper summarizes a complex gene regulatory network, composed of several transcription factors and microRNAs (miRNAs), that controls neuronal subclass specification in the nervous system of the nematode Caenorhabditis elegans.
Hobert
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Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University Medical Center, New York, New York 10032, USA.
D000818:Animals; D019521:Body Patterning / Q000235:genetics; D017173:Caenorhabditis elegans / Q000166:cytology / Q000235:genetics / Q000254:growth & development / Q000378:metabolism; D002454:Cell Differentiation; D018507:Gene Expression Regulation, Developmental; D017238:Genes, Helminth; D035683:MicroRNAs / Q000235:genetics*; D008959:Models, Neurological; D009154:Mutation; D009474:Neurons / Q000145:classification / Q000166:cytology* / Q000378:metabolism*
D035683:MicroRNAs