Cutaneous gamma/delta T-cell lymphoma: a histopathologic mimicker of lupus erythematosus profundus (lupus panniculitis).
In the newly revised World Health Organization (WHO)-European Organization for Research and Treatment of Cancer (EORTC) consensus classification for cutaneous lymphomas, cutaneous gamma/delta T-cell lymphoma (CGD-TCL) has been included as a provisional entity. This type of lymphomas, when involving the subcutaneous fat, can mimic both clinically and histologically other more indolent conditions, such as subcutaneous panniculitic T-cell lymphomas (SPTCL) and lupus erythematosus profundus (LEP), and multiple biopsies may be needed to obtain a correct diagnosis. A good correlation of the clinical data with the histopathology and immunohistochemistry are required for diagnosis. Herein, we describe a patient whose initial histopathologic findings ressembled LEP but presented an aggressive clinical course. A new biopsy was performed during the follow-up, and a final diagnosis of CGD-TCL was made.
Aguilera
Paula
P
Department of Dermatology, Hospital Clinic i Provincial de Barcelona, University of Barcelona, Spain. aguilisha@hotmail.com
Mascaró
J M
JM
Martinez
Antonio
A
Esteve
Jordi
J
Puig
Susana
S
Campo
Elias
E
Estrach
Teresa
T
D001707:Biopsy, Needle; D003937:Diagnosis, Differential; D018450:Disease Progression; D005500:Follow-Up Studies; D019675:Genes, T-Cell Receptor gamma / Q000235:genetics*; D005819:Genetic Markers; D006801:Humans; D007150:Immunohistochemistry; D016410:Lymphoma, T-Cell, Cutaneous / Q000145:classification* / Q000175:diagnosis / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D015435:Panniculitis, Lupus Erythematosus / Q000175:diagnosis / Q000473:pathology*; D018570:Risk Assessment; D014944:World Health Organization
D005819:Genetic Markers