title: Arabidopsis PPP family of serine/threonine phosphatases.
abstract: Serine/threonine-specific phosphoprotein phosphatases (PPPs) are ubiquitous enzymes in all eukaryotes, but their regulatory functions are largely unknown in higher plants. The Arabidopsis genome encodes 26 PPP catalytic subunits related to type 1, type 2A and so-called novel phosphatases, including four plant-specific enzymes carrying large N-terminal kelch-domains, but no apparent homologue of the PP2B family. The catalytic subunits of PPPs associate with regulatory protein partners that target them to well defined cellular locations and modulate their activity. Recent studies of phosphatase partners and their interactions have directed attention again to functional dissection of plant PPP families, and highlight their intriguing roles in the regulation of metabolism, cell cycle and development, as well as their roles in light, stress and hormonal signalling.
authors: Department of Medical Chemistry, Research Center for Molecular Medicine, Medical and Health Science Center, University of Debrecen, Egyetem tér 1, Debrecen H-4032, Hungary.
authors: Ilona
authors: I
authors: Farkas
authors: Viktor
authors: V
authors: Dombrádi
authors: Márton
authors: M
authors: Miskei
authors: László
authors: L
authors: Szabados
authors: Csaba
authors: C
authors: Koncz
mesh_terms: D017360:Arabidopsis / Q000201:enzymology*; D029681:Arabidopsis Proteins / Q000737:chemistry / Q000145:classification / Q000502:physiology*; D008954:Models, Biological; D009687:Nuclear Proteins / Q000737:chemistry / Q000502:physiology; D010749:Phosphoprotein Phosphatases / Q000737:chemistry / Q000145:classification / Q000502:physiology*; D010802:Phylogeny; D017434:Protein Structure, Tertiary; D021122:Protein Subunits / Q000378:metabolism / Q000502:physiology
chemical_list: D029681:Arabidopsis Proteins; D009687:Nuclear Proteins; D021122:Protein Subunits; C491501:PP7 protein, Arabidopsis; D010749:Phosphoprotein Phosphatases; C089641:protein phosphatase 5; C106079:protein phosphatase 6