title: Nodakenin, a coumarin compound, ameliorates scopolamine-induced memory disruption in mice.
abstract: Nodakenin is a coumarin compound initially isolated from the roots of Angelica gigas. In the present study, we investigated the effects of nodakenin on learning and memory impairments induced by scopolamine (1 mg/kg, i.p.) using the passive avoidance test, the Y-maze test, and the Morris water maze test in mice. Nodakenin (10 mg/kg, p.o.) administration significantly reversed scopolamine-induced cognitive impairments in the passive avoidance test and the Y-maze test (P<0.05), and also reduced escape latency during training in the Morris water maze test (P<0.05). Moreover, swimming times and distances within the target zone of the Morris water maze were greater in the nodakenin-treated group than in the scopolamine-treated group (P<0.05). In an in vitro study, nodakenin was found to inhibit acetylcholinesterase activity in a dose-dependent manner (IC(50)=84.7 microM). In addition, nodakenin was also found to inhibit acetylcholinesterase activity for 6 h in an ex-vivo study. These results suggest that nodakenin may be a useful for the treatment of cognitive impairment, and that its beneficial effects are mediated, in part, via the enhancement of cholinergic signaling.
authors: Department of Oriental Pharmaceutical Science and East-West Pharmaceutical Research Institute, College of Pharmacy, Kyung Hee University, Hoeki-dong, Dongdaemoon-Ku, Seoul 130-701, Republic of Korea.
authors: Dong Hyun
authors: DH
authors: Kim
authors: Do Yoon
authors: DY
authors: Kim
authors: Young Choong
authors: YC
authors: Kim
authors: Ji Wook
authors: JW
authors: Jung
authors: Seungjoo
authors: S
authors: Lee
authors: Byung Hoon
authors: BH
authors: Yoon
authors: Jae Hoon
authors: JH
authors: Cheong
authors: Yeong Shik
authors: YS
authors: Kim
authors: Sam Sik
authors: SS
authors: Kang
authors: Kwang Ho
authors: KH
authors: Ko
authors: Jong Hoon
authors: JH
authors: Ryu
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D002800:Cholinesterase Inhibitors / Q000494:pharmacology; D003374:Coumarins / Q000494:pharmacology / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004924:Escape Reaction / Q000187:drug effects; D005960:Glucosides / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008569:Memory Disorders / Q000139:chemically induced* / Q000188:drug therapy*; D051379:Mice; D008813:Mice, Inbred ICR; D015394:Molecular Structure; D012601:Scopolamine / Q000633:toxicity*
chemical_list: D002800:Cholinesterase Inhibitors; D003374:Coumarins; D005960:Glucosides; D012601:Scopolamine; C471579:nodakenin