[Prospective observational study of drug-induced hyperkalemia in hospitalized non dialized adult patients].
OBJECTIVE
To study the incidence and risk factors of drug-induced hyperkalemia in adult, hospitalized patients.


METHODS
A three months prospective observational study was used including all hospitalized, non dialyzed, patients older than 17 years who presented with a hyperkalemia egal or over 6 mmol/L. The studied variables were demographic, clinical, biological and therapeutic.


RESULTS
Forty patients, among 112 included, had a hyperkalemia promoted by drug(s) (3.5 cases for 1000 hospitalized patients). They were 73 +/- 15 years old and 72.5% had a past medical history of chronic renal failure. The hyperkalemia (6.42 +/- 0.48 mmol/L) was associated with an increase in creatininemia in 67.5% of patients. The most frequent treatment observed were renin angiotensin system drugs in 62.5% of patients, spironolactone in 37.5% or both drugs in 25%.


CONCLUSIONS
A better use of these drugs would be able to prevent some cases of hyperkalemia.
Onno
Céline
C
Service de Néphrologie, CHU d'Angers, Angers, France.
Rémignon
Héléna
H
Lagarce
Laurence
L
Bruhat
Corinne
C
Tourmen
Yves
Y
Subra
Jean-François
JF
Lainé-Cessac
Pascale
P
D000328:Adult; D000368:Aged; D005260:Female; D006760:Hospitalization; D006801:Humans; D006947:Hyperkalemia / Q000139:chemically induced* / Q000453:epidemiology; D007676:Kidney Failure, Chronic / Q000150:complications*; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012084:Renin-Angiotensin System / Q000502:physiology; D012307:Risk Factors