Effect of 5-HT2C receptor antagonist RS 102221 on mouse behavior.
Injection of RS 102221 (selective antagonist of serotonin 5-HT2C receptors) in a dose of 2 mg/kg reduced anxiety of mice in the light-darkness test and decreased the amplitude of the startle reflex. RS 102221 in a dose of 1 mg/kg reduced prestimulus inhibition of the startle reflex. No behavioral changes in Porsolt test and motor activity in the open field test were detected. Hence, RS 102221 is characterized by selective anxiolytic activity, and 5-HT2C receptors are involved in the mechanisms of anxiety and startle reflex formation.
Kuznetsova
E G
EG
Institute of Cytology and Genetics, Siberian Division of Russian Academy of Sciences, Novosibirsk. keg182@rambler.ru
Amstislavskaya
T G
TG
Shefer
E A
EA
Popova
N K
NK
D000818:Animals; D001007:Anxiety / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D009043:Motor Activity / Q000187:drug effects; D013216:Reflex, Startle / Q000187:drug effects*; D058826:Serotonin 5-HT2 Receptor Agonists; D013141:Spiro Compounds / Q000494:pharmacology* / Q000627:therapeutic use*; D018709:Statistics, Nonparametric; D013449:Sulfonamides / Q000494:pharmacology* / Q000627:therapeutic use*
C107821:8-(5-(5-amino-2,4-dimethoxyphenyl)-5-oxopentyl)-1,3,8-triazaspiro(4.5)decane-2,4-dione; D058826:Serotonin 5-HT2 Receptor Agonists; D013141:Spiro Compounds; D013449:Sulfonamides