title: Myopathy with tubulin-reactive inclusions in two cats.
abstract: Many types of inclusions have been described in human myopathies including but not limited to nemaline rod bodies, cylindrical spirals, tubular aggregates, cytoplasmic bodies, reducing bodies, and fingerprint bodies, and hyaline inclusions in myofibrillar myopathy and inclusion body myositis. There are very few reports describing inclusions in spontaneously occurring myopathies in cats, and these reports are limited to nemaline rod myopathy. A myopathy with tubulin-reactive crystalline inclusions has recently been reported in a human patient with a clinical presentation of myalgia and fatigue. Similarly, a myopathy with chronic, slowly progressive muscle weakness has been identified here in two unrelated cats. Inclusions were the only pathological change in skeletal muscle biopsies and, ultrastructurally, groups of crystalline structures were evident that had a subsarcolemmal or central location, rhomboid or rectangular shapes, lacked orientation, and were not membrane bound. The crystalline structures reacted positively with an antibody against tubulin. This feline myopathy may be the equivalent of the human myopathy with tubulin-positive crystalline inclusions.
authors: Department of Pathology 0709, University of California, San Diego, La Jolla, CA 92093-0709, USA. gshelton@ucsd.edu
authors: G Diane
authors: GD
authors: Shelton
authors: Beverly K
authors: BK
authors: Sturges
authors: Leslie A
authors: LA
authors: Lyons
authors: D Colette
authors: DC
authors: Williams
authors: Monica
authors: M
authors: Aleman
authors: Yun
authors: Y
authors: Jiang
authors: Andrew P
authors: AP
authors: Mizisin
mesh_terms: D000818:Animals; D002371:Cat Diseases / Q000473:pathology* / Q000503:physiopathology; D002415:Cats; D003460:Crystallization; D018450:Disease Progression; D005260:Female; D007150:Immunohistochemistry; D002479:Inclusion Bodies / Q000378:metabolism / Q000473:pathology*; D008297:Male; D046529:Microscopy, Electron, Transmission; D008954:Models, Biological; D018485:Muscle Fibers, Skeletal / Q000378:metabolism / Q000473:pathology; D018482:Muscle, Skeletal / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology; D009135:Muscular Diseases / Q000473:pathology / Q000503:physiopathology / Q000662:veterinary*; D012508:Sarcolemma / Q000378:metabolism / Q000473:pathology; D013045:Species Specificity; D014404:Tubulin / Q000378:metabolism*
chemical_list: D014404:Tubulin