SCOPing out proteases in long-term memory.
The ERK1/2 MAP kinase (MAPK) signaling pathway is important for the formation of long-term memories. In this issue, Shimizu et al. (2007) provide new insight into the regulation of this pathway by demonstrating that activation of MAP kinase occurs through the calcium-dependent degradation of SCOP (suprachiasmatic nucleus circadian oscillatory protein) by the protease calpain.
Bolshakov
Vadim Y
VY
Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA. vadimb@mclean.harvard.edu
D000818:Animals; D001921:Brain / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism; D002154:Calpain / Q000378:metabolism*; D006801:Humans; D007858:Learning; D020935:MAP Kinase Signaling System; D008568:Memory; D051379:Mice; D009687:Nuclear Proteins / Q000378:metabolism*; D010749:Phosphoprotein Phosphatases / Q000378:metabolism*
D009687:Nuclear Proteins; C519282:PHLPP1 protein, mouse; D010749:Phosphoprotein Phosphatases; D002154:Calpain; D002118:Calcium