Effects of altitude on spleen volume: sonographic assessment.
OBJECTIVE
To use sonography to determine changes that may arise in splenic volume in humans from regions of lower altitude who begin to live in regions of higher altitude.


METHODS
The study was conducted in the Turkish province of Ağri, at an altitude of 1750 m and included 108 healthy, nonsmoking, disease-free volunteers who had moved from regions at an altitude lower than 500 m. Length, width, and thickness of the spleen were measured using sonography. Splenic volume was calculated using the following standard ellipsoid formula: length x width x thickness x 0.523. Sonographic assessments were repeated at 3 and 6 months along with other blood tests, including hemoglobin, hematocrit, and platelet levels.


RESULTS
The mean +/- SD splenic volume was 299 +/- 97 cm(3) (range, 116-574 cm(3)). At 3 and 6 months, the splenic volumes decreased significantly compared to their initial values (p < 0.05). An increase in hemoglobin, hematocrit, and platelet count was observed in all subjects.


CONCLUSIONS
Our data show that splenic volume in healthy individuals who begins to live at high altitudes decreases gradually.
Sonmez
Guner
G
Department of Radiology, GATA Haydarpasa Teaching Hospital, 81327 Uskudar, Istanbul, Turkey.
Ozturk
Ersin
E
Basekim
C Cinar
CC
Mutlu
Hakan
H
Kilic
Selim
S
Onem
Yalcin
Y
Kizilkaya
Esref
E
D000328:Adult; D000531:Altitude; D001835:Body Weight; D005500:Follow-Up Studies; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D009929:Organ Size; D010976:Platelet Count; D011187:Posture; D016037:Single-Blind Method; D013154:Spleen / Q000033:anatomy & histology* / Q000000981:diagnostic imaging; D016683:Supine Position; D014421:Turkey; D014463:Ultrasonography
D006454:Hemoglobins