iPTREE-STAB: interpretable decision tree based method for predicting protein stability changes upon mutations.
We have developed a web server, iPTREE-STAB for discriminating the stability of proteins (stabilizing or destabilizing) and predicting their stability changes (delta deltaG) upon single amino acid substitutions from amino acid sequence. The discrimination and prediction are mainly based on decision tree coupled with adaptive boosting algorithm, and classification and regression tree, respectively, using three neighboring residues of the mutant site along N- and C-terminals. Our method showed an accuracy of 82% for discriminating the stabilizing and destabilizing mutants, and a correlation of 0.70 for predicting protein stability changes upon mutations.


BACKGROUND
http://bioinformatics.myweb.hinet.net/iptree.htm.


BACKGROUND
Dataset and other details are given.
Huang
Liang-Tsung
LT
Department of Computer Science and Information Engineering, Ming-Dao University, Changhua 523, Taiwan.
Gromiha
M Michael
MM
Ho
Shinn-Ying
SY
D000465:Algorithms; D019943:Amino Acid Substitution; D009154:Mutation; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry* / Q000235:genetics; D013816:Thermodynamics
D011506:Proteins