title: BMP signaling mutant mice exhibit glial cell maturation defects.
abstract: Bone morphogenetic proteins have been implicated in the development of oligodendrocytes and astrocytes, however, a role for endogenous BMP signaling in glial development has not been demonstrated in a genetic model. Using mice in which signaling via type I BMP receptors Bmpr1a and Bmpr1b have been inactivated in the neural tube, we demonstrate that BMP signaling contributes to the maturation of glial cells in vivo. At P0, mutant mice exhibited a 25-40% decrease in GFAP+ or S100beta+ astrocytes in the cervical spinal cord. The number of oligodendrocyte precursors and the timing of their emergence was unchanged in the mutant mice compared to the normals, however myelin protein expression and mature oligodendrocyte numbers were significantly reduced. These data indicate that BMP signaling promotes the generation of astrocytes and mature, myelinating oligodendrocytes in vivo but does not affect oligodendrocyte precursor development, thus suggesting tight regulation of BMP signaling to ensure proper gliogenesis.
authors: Department of Research Neurology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
authors: Jill
authors: J
authors: See
authors: Polina
authors: P
authors: Mamontov
authors: Kyung
authors: K
authors: Ahn
authors: Lara
authors: L
authors: Wine-Lee
authors: E Bryan
authors: EB
authors: Crenshaw
authors: Judith B
authors: JB
authors: Grinspan
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001253:Astrocytes / Q000378:metabolism* / Q000473:pathology; D055395:Bone Morphogenetic Protein 1; D019485:Bone Morphogenetic Proteins / Q000235:genetics / Q000378:metabolism*; D016923:Cell Death / Q000502:physiology; D002455:Cell Division / Q000502:physiology; D019070:Cell Lineage / Q000502:physiology; D002574:Cervical Vertebrae; D005260:Female; D008297:Male; D008666:Metalloendopeptidases / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D008815:Mice, Inbred Strains; D018345:Mice, Knockout; D009185:Myelin Proteins / Q000378:metabolism; D009436:Neural Tube Defects / Q000378:metabolism / Q000473:pathology*; D009836:Oligodendroglia / Q000378:metabolism* / Q000473:pathology; D011247:Pregnancy; D015398:Signal Transduction / Q000502:physiology*; D013116:Spinal Cord / Q000002:abnormalities / Q000378:metabolism / Q000473:pathology*; D013234:Stem Cells / Q000378:metabolism
chemical_list: D019485:Bone Morphogenetic Proteins; D009185:Myelin Proteins; D008666:Metalloendopeptidases; C525707:Bmp1 protein, mouse; D055395:Bone Morphogenetic Protein 1