title: Lack of association between NPHS2 gene polymorphisms and Henoch-Schönlein purpura nephritis.
abstract: Henoch-Schönlein purpura (HSP) is one of the most common forms of small-vessel vasculitis in childhood, and renal involvement (HSP nephritis, HSPN) is the main determinant of morbidity after acute phase. Considering the racial diversity and clinical heterogeneity in the prevalence, genetic factors might play a role in pathogenesis of HSP and HSPN. Direct sequencing was performed after PCR amplification of all 8 exons of the NPHS2 gene in 20 Chinese children with HSPN and 30 controls in present study. The genetic analyses revealed 3 polymorphisms (954T > C heterozygous, 1038A > G heterozygous and homozygous, all in exon 8) in 7 out of 20 patients studied, but there was no significant difference in the genotypic and allelic frequencies of these polymorphisms between the patients and controls. The result did not support the possible role of the NPHS2 gene in susceptibility to HSPN in the population studied. Studies in a larger sample population with different genetic backgrounds will be necessary in the future.
authors: Department of Epidemiology, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, PR China.
authors: Yang
authors: Y
authors: Zhang
authors: Xu
authors: X
authors: Xudong
authors: Lizhong
authors: L
authors: Du
authors: Weizhong
authors: W
authors: Gu
authors: Yuwen
authors: Y
authors: Dai
authors: Aimin
authors: A
authors: Liu
authors: Yonghui
authors: Y
authors: Xia
authors: Jianhua
authors: J
authors: Mao
mesh_terms: D000293:Adolescent; D044466:Asian People / Q000235:genetics; D001706:Biopsy; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D002681:China; D005091:Exons / Q000235:genetics; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D011695:IgA Vasculitis / Q000150:complications* / Q000208:ethnology / Q000235:genetics*; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics*; D007668:Kidney / Q000473:pathology; D008565:Membrane Proteins / Q000235:genetics*; D009393:Nephritis / Q000209:etiology* / Q000473:pathology; D011110:Polymorphism, Genetic / Q000235:genetics*
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; C407223:NPHS2 protein