title: Systemic doxycycline and nonsurgical periodontal treatment in diabetic patients.
abstract: METHODS
  This was a randomised controlled trial (RCT).
  
  
  METHODS
  Group 1 (30 patients) was given oral-hygiene instruction, scaling and root planing, chlorhexidine rinses twice a day and doxycycline (100 mg/day for 15 days). Group 2 (30 patients) had the same treatment but without doxycycline.
  
  
  METHODS
  Plaque index (PI), probing pocket depth (PPD), clinical attachment levels (CAL) and bleeding on probing (BOP) were recorded.
  
  
  RESULTS
  Both groups had a measurable improvement in all periodontal parameters, since PI, BOP, PPD and CAL were reduced. The reduction in PPD of 6 mm and in BOP became statistically significant when doxycycline was used (group 1), however.
  
  
  CONCLUSIONS
  Although both periodontal treatment regimens are effective in type-1 diabetics, the use of doxycycline as an adjunct provided more significant results when good plaque control was achieved.
authors: Department of Periodontology, Centre for Dental, Oral and Maxillofacial Medicine (Carolinum), Hospital of the Johann Wolfgang Goethe-Universität Frankfurt am Main, Frankfurt/Main, Germany.
authors: Peter
authors: P
authors: Eickholz