title: Short-term clinical exposure evaluation of a second-generation electrically heated cigarette smoking system.
abstract: This randomized, controlled, forced-switching, open-label, parallel-group study in 100 adult male and female smokers of conventional cigarettes evaluated 8 biomarkers of tobacco smoke exposure. After baseline exposure determinations, adult smokers were switched to a second-generation electrically heated cigarette smoking system (EHCSS) for 8 days in a clinical setting. After 8 days of smoking the EHCSS biomarkers of exposure decreased by 43% to 85% compared to baseline. After correction for residual effects (carryover effects due to long elimination half-life and non-tobacco-confounding sources of exposure), reductions in exposure ranged from 59% to 97%. Results from this short-term clinical exposure study indicate that switching from a conventional cigarette to a second-generation electrically heated cigarette smoking system substantially reduced the exposure to several measured potentially harmful constituents of tobacco smoke.
authors: Philip Morris USA, Research Center, 4102 Commerce Road, Richmond, VA 23234, USA. Hans-Juergen.Roethig@pmusa.com
authors: Hans J
authors: HJ
authors: Roethig
authors: Barbara K
authors: BK
authors: Zedler
authors: Robin D
authors: RD
authors: Kinser
authors: Shixia
authors: S
authors: Feng
authors: Bettie L
authors: BL
authors: Nelson
authors: Qiwei
authors: Q
authors: Liang
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000652:urine; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009538:Nicotine / Q000652:urine; D012907:Smoking / Q000378:metabolism* / Q000652:urine; D014028:Tobacco Smoke Pollution / Q000009:adverse effects / Q000032:analysis*
chemical_list: D015415:Biomarkers; D014028:Tobacco Smoke Pollution; D009538:Nicotine