Targeting caspase-1 in sepsis: a novel approach to an old problem.
Matute-Bello
Gustavo
G
Center for Lung Biology, Division of Pulmonary & Critical Care Medicine, University of Washington School of Medicine, Campus Box 356522, WA 98195-6522, Seattle, USA. matuteb@u.washington.edu.
D020170:Caspase 1 / Q000502:physiology; D061945:Caspase Inhibitors; D006801:Humans; D053583:Interleukin-1beta / Q000096:biosynthesis* / Q000502:physiology; D009842:Oligopeptides / Q000494:pharmacology* / Q000627:therapeutic use; D018805:Sepsis / Q000188:drug therapy / Q000201:enzymology*
D061945:Caspase Inhibitors; D053583:Interleukin-1beta; D009842:Oligopeptides; C118632:tyrosyl-valyl-alanyl-aspartal; D020170:Caspase 1