Control of the NF-kappaB inhibitor IkappaBalpha in pathogen infection.
One of the important cellular factors involved in the regulation of the host antimicrobial response is the immediate early response transcription factor NF-kappaB (nuclear factor kappaB). Human pathogenic micro-organisms trigger cellular signal transduction pathways that induce NF-kappaB, but pathogens have also found ways to overcome the inflammatory response through active manipulation of NF-kappaB regulators. Exploration of the mechanisms that influence NF-kappaB activity could contribute to a better understanding of the molecular pathogenesis of microbial infections and could be important for potential therapeutic intervention that may be relevant in a wide variety of inflammatory diseases.
Naumann
M
M
Medical Faculty, Institute of Experimental Internal Medicine, Otto-von-Guericke-University, Leipziger Strasse, 39120 Magdeburg, Germany. naumann@medizin.uni-magdeburg.de
D001424:Bacterial Infections / Q000503:physiopathology / Q000517:prevention & control; D004847:Epithelial Cells / Q000502:physiology; D006801:Humans; D020672:I-kappa B Proteins / Q000502:physiology*; D007239:Infections / Q000503:physiopathology*; D000072000:NF-KappaB Inhibitor alpha; D016328:NF-kappa B / Q000037:antagonists & inhibitors*; D051193:Toll-Like Receptors / Q000502:physiology
D020672:I-kappa B Proteins; D016328:NF-kappa B; C000606204:NFKBIA protein, human; D051193:Toll-Like Receptors; D000072000:NF-KappaB Inhibitor alpha