H pylori are associated with chronic cholecystitis.
OBJECTIVE
To study whether H pylori are associated with chronic cholecystitis.


METHODS
The subjects were divided into three groups: H pylori-infected cholecystitis group, H pylori-negative cholecystitis group and control group. Pathologic changes of the gallbladder were observed by optic and electronic microscopes and the levels of interleukin-1, 6 and 8 (IL-1, 6 and 8) were detected by radioimmunoassay.


RESULTS
Histological evidence of chronic cholecystitis including degeneration, necrosis, inflammatory cell infiltration, were found in the region where H pylori colonized. Levels of IL-1, 6 and 8 in gallbladder mucosa homogenates were significantly higher in H pylori-infected cholecystitis group than those in H pylori-negative cholecystitis group and control group.


CONCLUSIONS
H pylori infection may be related to cholecystitis.
Chen
Dong-Feng
DF
Department of Gastroenterology, Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing 400042, China. dfchen9@hotmail.com
Hu
Lu
L
Yi
Ping
P
Liu
Wei-Wen
WW
Fang
Dian-Chun
DC
Cao
Hong
H
D016022:Case-Control Studies; D002764:Cholecystitis / Q000378:metabolism / Q000382:microbiology* / Q000473:pathology; D002908:Chronic Disease; D005704:Gallbladder / Q000378:metabolism / Q000382:microbiology* / Q000473:pathology; D016481:Helicobacter Infections / Q000150:complications*; D016480:Helicobacter pylori / Q000472:pathogenicity; D006801:Humans; D007375:Interleukin-1 / Q000378:metabolism; D015850:Interleukin-6 / Q000378:metabolism; D016209:Interleukin-8 / Q000378:metabolism; D008679:Metaplasia / Q000378:metabolism / Q000382:microbiology / Q000473:pathology; D009092:Mucous Membrane / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure
D007375:Interleukin-1; D015850:Interleukin-6; D016209:Interleukin-8