title: Gemcitabine radiosensitizes multiple myeloma cells to low let, but not high let, irradiation.
abstract: The radiosensitizing properties of gemcitabine in relation to low Linear Energy Transfer (LET) particles (Cobalt 60) and high-LET particles (alpha-RIT (213)Bi-radiolabeled CHX-DTPA-B-B4) were analyzed. Three multiple myeloma cell lines (LP1, RPMI 8226, U266) were irradiated with or without 10 nM gemcitabine 24 h prior to radiation. Gemcitabine led to radiosensitization of LP1 and U266 cells with low-LET (Radiation Enhancement Ratio: 1.55 and 1.49, respectively) but did not radiosensitize any cell line when combined with high-LET.
authors: Département de Recherche en Cancérologie, Université de Nantes, Nantes, France.
authors: Stéphane
authors: S
authors: Supiot
authors: Francois
authors: F
authors: Thillays
authors: Emmanuel
authors: E
authors: Rio
authors: Sébastien
authors: S
authors: Gouard
authors: Alfred
authors: A
authors: Morgenstern
authors: Frank
authors: F
authors: Bruchertseifer
authors: Marc-André
authors: MA
authors: Mahé
authors: Jean-François
authors: JF
authors: Chatal
authors: François
authors: F
authors: Davodeau
authors: Michel
authors: M
authors: Chérel
mesh_terms: D000512:Alpha Particles; D000964:Antimetabolites, Antineoplastic / Q000494:pharmacology; D002453:Cell Cycle / Q000187:drug effects / Q000528:radiation effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects / Q000528:radiation effects; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D003841:Deoxycytidine / Q000031:analogs & derivatives* / Q000494:pharmacology; D005720:Gamma Rays; D006801:Humans; D018499:Linear Energy Transfer; D009101:Multiple Myeloma / Q000473:pathology / Q000532:radiotherapy*; D011829:Radiation Dosage; D011836:Radiation Tolerance / Q000187:drug effects*; D011838:Radiation-Sensitizing Agents / Q000494:pharmacology*; D000093542:Gemcitabine
chemical_list: D000964:Antimetabolites, Antineoplastic; D011838:Radiation-Sensitizing Agents; D003841:Deoxycytidine; D000093542:Gemcitabine