title: Fetal electrocardiogram ST-segment analysis and prediction of neonatal acidosis.
abstract: OBJECTIVE
  To determine the diagnostic value of fetal ST-segment analysis (STAN) in predicting neonatal acidosis.
  
  
  METHODS
  The STAN S21 was used to monitor singleton fetuses in labor with abnormal FHR. Physicians later reviewed tracings to identify any ST events dictating intervention. Outcome measures were umbilical artery pH< or =7.15 and pH< or =7.05 at birth. The sensitivity, specificity, PPV, and NPV of a significant ST event to predict both outcomes were calculated.
  
  
  RESULTS
  Analysis included 411 women. Sensitivity of a significant ST event for screening pH< or =7.15 (21.9%) was 38% (41/108), specificity 83% (252/303), PPV 45% (41/92) and NPV 79% (252/319), and for pH< or =7.05, it was (3.4%), 62.5% (10/16), 79% (313/395), 11% (10/92), and 98% (313/319), respectively.
  
  
  CONCLUSIONS
  In a population with abnormal FHR in labor, STAN sensitivity is moderate (almost 40%) for predicting pH< or =7.15 and better (almost 60%) for more severe acidosis (pH< or =7.05).
authors: Département de Gynécologie-Obstétrique, CHU de Hautepierre, Strasbourg cedex, France. cvayssiere@club-internet.fr
authors: C
authors: C
authors: Vayssiere
authors: R
authors: R
authors: Haberstich
authors: V
authors: V
authors: Sebahoun
authors: E
authors: E
authors: David
authors: E
authors: E
authors: Roth
authors: B
authors: B
authors: Langer
mesh_terms: D000138:Acidosis / Q000175:diagnosis*; D015415:Biomarkers; D004562:Electrocardiography; D005188:False Negative Reactions; D005189:False Positive Reactions; D005260:Female; D005312:Fetal Blood / Q000502:physiology*; D005316:Fetal Distress / Q000175:diagnosis* / Q000503:physiopathology; D005323:Fetal Monitoring / Q000379:methods*; D005333:Fetus / Q000502:physiology*; D006801:Humans; D007231:Infant, Newborn; D011237:Predictive Value of Tests; D011247:Pregnancy
chemical_list: D015415:Biomarkers