GTP-binding proteins of the Rho/Rac family: regulation, effectors and functions in vivo.
Rho/Rac proteins constitute a subgroup of the Ras superfamily of GTP hydrolases. Although originally implicated in the control of cytoskeletal events, it is currently known that these GTPases coordinate diverse cellular functions, including cell polarity, vesicular trafficking, the cell cycle and transcriptomal dynamics. In this review, we will provide an overview on the recent advances in this field regarding the mechanism of regulation and signaling, and the roles in vivo of this important GTPase family.
Bustelo
Xosé R
XR
Centro de Investigación del Cáncer and Instituto de Biología Molecular y Celular del Cáncer (IBMCC), CSIC-University of Salamanca, Salamanca, Spain. xbustelo@usal.es
Sauzeau
Vincent
V
Berenjeno
Inmaculada M
IM
D000818:Animals; D005786:Gene Expression Regulation; D010802:Phylogeny; D011485:Protein Binding; D014158:Transcription, Genetic / Q000235:genetics; D020744:rac GTP-Binding Proteins / Q000737:chemistry / Q000145:classification / Q000235:genetics / Q000378:metabolism*; D020741:rho GTP-Binding Proteins / Q000737:chemistry / Q000145:classification / Q000235:genetics / Q000378:metabolism*
D020744:rac GTP-Binding Proteins; D020741:rho GTP-Binding Proteins