title: Scutiaquinones A and B, perylenequinones from the roots of Scutia myrtina with anthelmintic activity.
abstract: Haemonchus contortus is a worm that causes serious infections in livestock. Two new perylenequinones, scutiaquinone A (1) and scutiaquinone B (2), have been isolated from a methanol extract of the roots of Scutia myrtina by bioassay-guided fractionation, using an assay that kills this parasite in vitro. The structures of compounds 1 and 2 were elucidated by analysis of their 1D- and 2D-NMR and MS spectra. The isolation, structure, and anthelmintic activities of compounds 1 and 2 are reported.
authors: Natural Products Chemistry, Merck Research Laboratories, P.O. Box 2000, Rahway, NJ 07065, USA.
authors: Sloan
authors: S
authors: Ayers
authors: Deborah L
authors: DL
authors: Zink
authors: Kenneth
authors: K
authors: Mohn
authors: Joanne Staats
authors: JS
authors: Powell
authors: Christine M
authors: CM
authors: Brown
authors: Terry
authors: T
authors: Murphy
authors: Robert
authors: R
authors: Brand
authors: Seef
authors: S
authors: Pretorius
authors: Dennis
authors: D
authors: Stevenson
authors: Donald
authors: D
authors: Thompson
authors: Sheo B
authors: SB
authors: Singh
mesh_terms: D000818:Animals; D000829:Animals, Domestic / Q000469:parasitology*; D000871:Anthelmintics / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006189:Haemonchus / Q000187:drug effects*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010569:Perylene / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D011809:Quinones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D027823:Rhamnaceae / Q000737:chemistry*; D013019:South Africa
chemical_list: D000871:Anthelmintics; D011809:Quinones; C519142:scutiaquinone A; C519143:scutiaquinone B; D010569:Perylene