Heritability of determinants of the metabolic syndrome among healthy Arabs of the Oman family study.
The metabolic syndrome, as defined by the International Diabetes Federation, was investigated in five large, extended, highly consanguineous, healthy Omani Arab families of a total of 1277 individuals. Heritability (h2) of the phenotypic abnormalities that make up the syndrome and other related traits was estimated by variance decomposition method using SOLAR software. The overall prevalence of the syndrome was 23%. The prevalence of abnormalities making the syndrome in a descending order were: obligatory waist circumference, hypertension, raised fasting blood glucose, low serum high-density lipoprotein (HDL), and raised serum triglycerides (TGs). Highly significant, but widely spread, h2 values were obtained for: height (0.68), weight (0.68), BMI (0.68), serum HDL (0.63), serum leptin (0.55), percentage body fat (0.53), total serum cholesterol (0.53), fasting serum insulin (0.51), homeostasis model assessment-insulin resistance index (0.48), serum TG (0.43), waist circumference (0.40), diastolic blood pressure (0.38), and 2-hour glucose level (0.17), whereas for the metabolic syndrome itself, h2 was 0.38. The wide spread of h2 results (0.07 to 0.68) indicates that some determinants, such as weight, BMI, and HDL level, are under significant genetic influence among the Omani Arabs. Other determinants such as insulin resistance, abdominal obesity, diastolic blood pressure, and TG levels seem to be more environmentally driven.
Bayoumi
Riad A
RA
Department of Biochemistry, College of Medicine and Health Sciences, Sultan Qaboos University, Al Khod, P.O. Box 35, Muscat 123, Sultanate of Oman. bayoumi@squ.edu.om
Al-Yahyaee
Saeed A S
SA
Albarwani
Sulayma A
SA
Rizvi
Syed G
SG
Al-Hadabi
Saleh
S
Al-Ubaidi
Firial F
FF
Al-Hinai
Ali T
AT
Al-Kindi
Mohammed N
MN
Adnan
Haleema T
HT
Al-Barwany
Hameeda S
HS
Comuzzie
Antony G
AG
Cai
Guowen
G
Lopez-Alvarenga
Juan C
JC
Hassan
Mohammed O
MO
D000293:Adolescent; D000328:Adult; D018912:Arabs / Q000235:genetics*; D003241:Consanguinity; D005260:Female; D006262:Health; D006801:Humans; D040582:Inheritance Patterns; D008297:Male; D024821:Metabolic Syndrome / Q000235:genetics*; D008875:Middle Aged; D009850:Oman; D010375:Pedigree