title: Neurogenesis and major depression: implications from proteomic analyses of hippocampal proteins in a rat depression model.
abstract: Major depression is one of the most disabling disorders. Yet, the pathogenesis of this mental disorder is poorly understood. Hippocampus is generally believed to be associated with pathogenesis of depression. In this study, we adopted a proteomic approach to examine possible alterations of protein expression in the hippocampus of a rat depression model. Our results suggest that neurogenesis in hippocampus may play an important role in the pathogenesis of major depression.
authors: Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, The Key Laboratory of Diagnostic Medicine Designated by the Ministry of Education, Chongqing 400016, China.
authors: Jun
authors: J
authors: Mu
authors: Peng
authors: P
authors: Xie
authors: Ze-Song
authors: ZS
authors: Yang
authors: De-Lan
authors: DL
authors: Yang
authors: Fa-Jin
authors: FJ
authors: Lv
authors: Tian-You
authors: TY
authors: Luo
authors: Yong
authors: Y
authors: Li
mesh_terms: D000818:Animals; D003863:Depression / Q000473:pathology*; D004195:Disease Models, Animal; D015180:Electrophoresis, Gel, Two-Dimensional / Q000379:methods; D005786:Gene Expression Regulation / Q000502:physiology*; D006624:Hippocampus / Q000378:metabolism* / Q000503:physiopathology*; D007525:Isoelectric Focusing / Q000379:methods; D008297:Male; D009474:Neurons / Q000502:physiology*; D038081:Organogenesis; D040901:Proteomics / Q000379:methods; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors