[Molecular imaging for drug development].
In vivo molecular imaging has become a key technology for drug development and pathophysiological science. We are mostly utilizing PET (positron emission tomography) as a first-choice modality, because of its ultra-high sensitivity for molecules, adequate temporal and spatial resolution, and especially broad spectrum of target molecules. The present status for development of PET molecular probes, instrumentations including microPET, and the methods for quantitative analyses will be introduced with some examples. In vivo molecular imaging could bring the high-quality information about: (1) Molecular diagnosis for living patients with symptoms (2) Closer approach for etiology and differential diagnosis (3) Direct follow-up of key molecules as disease markers (4) Pharmacokinetics/Pharmacodynamics in primates/human (5) Dose finding information for individuals, corresponding to SNP (6) Direct evidence for accumulation in non-target organs: Related to adverse effects (7) Drug effects with surrogate markers (8) Early decision of dropout substances (drug candidates). In 2005, RIKEN and National Institute of Radiological Science were selected as the key centers for development of All-Japan research network to further promote mutual international and multi-disciplinary collaboration on in vivo molecular imaging. On this occasion, the concept and project themes will also be introduced.
Watanabe
Yasuyoshi
Y
Molecular Imaging Research Program, FRS, RIKEN, 6-7-3 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan.
D016229:Amyloid beta-Peptides / Q000378:metabolism; D000818:Animals; D015415:Biomarkers; D001708:Biopterins / Q000031:analogs & derivatives / Q000378:metabolism; D002648:Child; D002658:Developmental Disabilities / Q000175:diagnosis / Q000378:metabolism / Q000628:therapy; D003937:Diagnosis, Differential; D004338:Drug Combinations; D015195:Drug Design; D017850:Economics, Pharmaceutical; D015673:Fatigue Syndrome, Chronic / Q000175:diagnosis / Q000378:metabolism; D006801:Humans; D025202:Molecular Diagnostic Techniques; D015335:Molecular Probes; D020641:Polymorphism, Single Nucleotide; D049268:Positron-Emission Tomography / Q000295:instrumentation / Q000379:methods; D050486:Serotonin Plasma Membrane Transport Proteins / Q000378:metabolism
D016229:Amyloid beta-Peptides; D015415:Biomarkers; D004338:Drug Combinations; D015335:Molecular Probes; D050486:Serotonin Plasma Membrane Transport Proteins; D001708:Biopterins; C003402:sapropterin