Nanostructured lipid carriers-containing anticancer compounds: preparation, characterization, and cytotoxicity studies.
This article describes the development of nanostructured lipid carriers (NLC) as colloidal carriers for two antitumor compounds that possess a remarkable antineoplastic activity. But their limited stability and low solubility in water could give a very low parenteral bioavailability. Results revealed an enhancement of the cytotoxicity effect of drug-loaded NLC on human prostate cancer (PC-3) and human hepatocellular carcinoma (HuH-6, HuH-7) cell lines with respect to that of both free drugs. Results of characterization studies strongly support the potential application of these drugs-loaded NLC as prolonged delivery systems for lipophilic drugs by several administration routes, in particular for intravenous administration.
Bondì
Maria Luisa
ML
Istituto per lo Studio dei Materiali Nanostrutturati, sez. di Palermo, Consiglio Nazionale delle Ricerche, Palermo, Italy. marialuisa.bondi@ismn.cnr.it
Craparo
Emanuela Fabiola
EF
Giammona
Gaetano
G
Cervello
Melchiorre
M
Azzolina
Antonina
A
Diana
Patrizia
P
Martorana
Anna
A
Cirrincione
Girolamo
G
D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D004337:Drug Carriers / Q000737:chemistry*; D004339:Drug Compounding; D004563:Electrochemistry; D006801:Humans; D008055:Lipids / Q000737:chemistry*; D053758:Nanoparticles; D010316:Particle Size; D010949:Plasma / Q000737:chemistry; D012995:Solubility
D000970:Antineoplastic Agents; D004337:Drug Carriers; D008055:Lipids