title: Endobronchitis by Scedosporium apiospermum in a child with cystic fibrosis.
abstract: A case of endobronchitis by Scedosporium apiospermum in a child with cystic fibrosis is presented. The bronchial aspirate's cytology showed the presence of a large amount of septated-dichotomized hyphae. The bronchial aspirate's culture showed the presence of Scedosporium apiospermum in a pure culture of three consecutive samples. The scanning electron microscopy study of the mucosal surface revealed scarce mycelia with the presence of abundant conidiae. The transmission electron microscopy of the mucosa revealed inflammatory infiltrates constituted by macrophages, polymorphonuclear leukocytes, a lot of dichotomized mycelia and macrophages with hyphae and conidiae within the phagosomes. The patient was treated with amphotericin B and itraconazole.
authors: Laboratorio de Biología Molecular y Microscopía Electrónica, Facultad Mexicana de Medicina, Universidad La Salle, Mexico. ovztsuji@yahoo.com.mx
authors: Oscar
authors: O
authors: Vázquez-Tsuji
authors: Teresita
authors: T
authors: Campos Rivera
authors: Adrián
authors: A
authors: Rondán Zárate
authors: Mónica
authors: M
authors: Mirabal García
mesh_terms: D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use*; D001980:Bronchi / Q000382:microbiology; D001991:Bronchitis / Q000188:drug therapy / Q000209:etiology / Q000382:microbiology*; D002648:Child; D003550:Cystic Fibrosis / Q000150:complications*; D004198:Disease Susceptibility; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use; D008854:Microscopy, Electron; D008271:Mycetoma / Q000188:drug therapy / Q000209:etiology / Q000382:microbiology*; D020545:Respiratory Mucosa / Q000382:microbiology; D021681:Scedosporium / Q000254:growth & development / Q000302:isolation & purification* / Q000648:ultrastructure
chemical_list: D000935:Antifungal Agents; D017964:Itraconazole; D000666:Amphotericin B