Development and validation of a physiology-based model for the prediction of oral absorption in monkeys.
OBJECTIVE
The development and validation of a physiology-based absorption model for orally administered drugs in monkeys is described.


METHODS
Physiological parameters affecting intestinal transit and absorption of an orally administered drug in monkeys have been collected from the literature and implemented in a physiological model for passive absorption previously developed for rats and humans. Predicted fractions of dose absorbed have been compared to experimentally observed values for a set of N = 37 chemically diverse drugs. A sensitivity analysis was performed to assess the influence of various physiological model parameters on the predicted fraction dose absorbed.


RESULTS
A Pearson's correlation coefficient of 0.94 (95% confidence interval: [0.88, 0.97]; p < 0.0001) between the predicted and observed fraction dose absorbed in monkeys was obtained for compounds undergoing non-solubility limited passive absorption (N = 29). The sensitivity analysis revealed that the predictions of fractions dose absorbed in monkeys are very sensitive with respect to inter-individual variations of the small intestinal transit time.


CONCLUSIONS
The model is well suited to predict the fraction dose absorbed of passively absorbed compounds after oral administration and to assess the influence of inter-individual physiological variability on oral absorption in monkeys.
Willmann
Stefan
S
Bayer Technology Services GmbH, Process Technology/Systems Biology, Building E41, Leverkusen, Germany. Stefan.Willmann@Bayertechnology.com
Edginton
Andrea N
AN
Dressman
Jennifer B
JB
D000284:Administration, Oral; D000818:Animals; D005772:Gastrointestinal Transit; D006801:Humans; D007408:Intestinal Absorption; D008253:Macaca mulatta; D008954:Models, Biological; D004364:Pharmaceutical Preparations / Q000008:administration & dosage / Q000378:metabolism*; D010599:Pharmacokinetics; D051381:Rats; D015203:Reproducibility of Results; D013045:Species Specificity
D004364:Pharmaceutical Preparations