title: Endothelial cell migration during angiogenesis.
abstract: Endothelial cell migration is essential to angiogenesis. This motile process is directionally regulated by chemotactic, haptotactic, and mechanotactic stimuli and further involves degradation of the extracellular matrix to enable progression of the migrating cells. It requires the activation of several signaling pathways that converge on cytoskeletal remodeling. Then, it follows a series of events in which the endothelial cells extend, contract, and throw their rear toward the front and progress forward. The aim of this review is to give an integrative view of the signaling mechanisms that govern endothelial cell migration in the context of angiogenesis.
authors: Le Centre de recherche en cancérologie, l'Université Laval, L'Hôtel-Dieu de Québec, Québec, Canada.
authors: Laurent
authors: L
authors: Lamalice
authors: Fabrice
authors: F
authors: Le Boeuf
authors: Jacques
authors: J
authors: Huot
mesh_terms: D000199:Actins / Q000378:metabolism; D042682:Angiopoietins / Q000502:physiology; D000818:Animals; D002465:Cell Movement / Q000502:physiology*; D003599:Cytoskeleton / Q000378:metabolism; D042783:Endothelial Cells / Q000166:cytology / Q000502:physiology*; D005109:Extracellular Matrix / Q000378:metabolism; D006801:Humans; D018919:Neovascularization, Physiologic / Q000502:physiology*; D020286:Pericytes / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D000199:Actins; D042682:Angiopoietins