Antimicrobial effects of silver nanoparticles.
The antimicrobial effects of silver (Ag) ion or salts are well known, but the effects of Ag nanoparticles on microorganisms and antimicrobial mechanism have not been revealed clearly. Stable Ag nanoparticles were prepared and their shape and size distribution characterized by particle characterizer and transmission electron microscopic study. The antimicrobial activity of Ag nanoparticles was investigated against yeast, Escherichia coli, and Staphylococcus aureus. In these tests, Muller Hinton agar plates were used and Ag nanoparticles of various concentrations were supplemented in liquid systems. As results, yeast and E. coli were inhibited at the low concentration of Ag nanoparticles, whereas the growth-inhibitory effects on S. aureus were mild. The free-radical generation effect of Ag nanoparticles on microbial growth inhibition was investigated by electron spin resonance spectroscopy. These results suggest that Ag nanoparticles can be used as effective growth inhibitors in various microorganisms, making them applicable to diverse medical devices and antimicrobial control systems.
Kim
Jun Sung
JS
Laboratory of Toxicology, Seoul National University, Seoul, Korea.
Kuk
Eunye
E
Yu
Kyeong Nam
KN
Kim
Jong-Ho
JH
Park
Sung Jin
SJ
Lee
Hu Jang
HJ
Kim
So Hyun
SH
Park
Young Kyung
YK
Park
Yong Ho
YH
Hwang
Cheol-Yong
CY
Kim
Yong-Kwon
YK
Lee
Yoon-Sik
YS
Jeong
Dae Hong
DH
Cho
Myung-Haing
MH
D000111:Acetylcysteine / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004578:Electron Spin Resonance Spectroscopy; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development; D008826:Microbial Sensitivity Tests; D053758:Nanoparticles / Q000648:ultrastructure; D012834:Silver / Q000494:pharmacology*; D012835:Silver Nitrate; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development; D013696:Temperature
D000900:Anti-Bacterial Agents; D012834:Silver; D012835:Silver Nitrate; D000111:Acetylcysteine