title: Monounsaturated fat-rich diet prevents central body fat distribution and decreases postprandial adiponectin expression induced by a carbohydrate-rich diet in insulin-resistant subjects.
abstract: OBJECTIVE
  Central obesity is associated with insulin resistance through factors that are not fully understood. We studied the effects of three different isocaloric diets on body fat distribution, insulin sensitivity, and peripheral adiponectin gene expression.
  
  
  METHODS
  Eleven volunteers, offspring of obese type 2 diabetic patients with abdominal fat deposition, were studied. These subjects were considered insulin resistant as indicated by Matsuda index values <4 after an oral glucose tolerance test, and they maintained A1C <6.5% without therapeutic intervention. All subjects underwent three dietary periods of 28 days each in a crossover design: 1) diet enriched in saturated fat (SAT), 2) diet rich in monounsaturated fat (MUFA) (Mediterranean diet), and 3) diet rich in carbohydrates (CHOs).
  
  
  RESULTS
  Weight, body composition, and resting energy expenditure remained unchanged during the three sequential dietary periods. Using dual-energy X-ray absorptiometry we observed that when patients were fed a CHO-enriched diet, their fat mass was redistributed toward the abdominal depot, whereas periphery fat accumulation decreased compared with isocaloric MUFA-rich and high-SAT diets (ANOVA P < 0.05). Changes in fat deposition were associated with decreased postprandial mRNA adiponectin levels in peripheral adipose tissue and lower insulin sensitivity index values from a frequently sampled insulin-assisted intravenous glucose tolerance test in patients fed a CHO-rich diet compared with a MUFA-rich diet (ANOVA P < 0.05).
  
  
  CONCLUSIONS
  An isocaloric MUFA-rich diet prevents central fat redistribution and the postprandial decrease in peripheral adiponectin gene expression and insulin resistance induced by a CHO-rich diet in insulin-resistant subjects.
authors: Lipids and Atherosclerosis Research Unit, Reina Sofía University Hospital, Córdoba, Spain. japaniaguag@yahoo.es
authors: J A
authors: JA
authors: Paniagua
authors: A
authors: A
authors: Gallego de la Sacristana
authors: I
authors: I
authors: Romero
authors: A
authors: A
authors: Vidal-Puig
authors: J M
authors: JM
authors: Latre
authors: E
authors: E
authors: Sanchez
authors: P
authors: P
authors: Perez-Martinez
authors: J
authors: J
authors: Lopez-Miranda
authors: F
authors: F
authors: Perez-Jimenez
mesh_terms: D050153:Abdominal Fat / Q000187:drug effects*; D052242:Adiponectin / Q000096:biosynthesis*; D050154:Adiposity / Q000187:drug effects; D000368:Aged; D001823:Body Composition; D001835:Body Weight; D018592:Cross-Over Studies; D004040:Dietary Carbohydrates / Q000494:pharmacology*; D004042:Dietary Fats, Unsaturated; D004734:Energy Metabolism; D005229:Fatty Acids, Monounsaturated / Q000494:pharmacology*; D005260:Female; D015870:Gene Expression; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D019518:Postprandial Period
chemical_list: D052242:Adiponectin; D004040:Dietary Carbohydrates; D004042:Dietary Fats, Unsaturated; D005229:Fatty Acids, Monounsaturated