Unconventional roles of the NADPH oxidase: signaling, ion homeostasis, and cell death.
Although the central role of the phagocytic NADPH oxidase in mediating bacterial killing has long been appreciated, this sophisticated enzyme complex serves various other important functions. This Perspective focuses on these underappreciated roles of phagocytic NADPH oxidase, highlighting recent work implicating reactive oxygen species in triggering an unconventional form of cell death.
Steinberg
Benjamin E
BE
Program in Cell Biology, Hospital for Sick Children, Toronto, Canada.
Grinstein
Sergio
S
D016923:Cell Death / Q000276:immunology; D004579:Electron Transport / Q000276:immunology; D005109:Extracellular Matrix; D006706:Homeostasis / Q000276:immunology*; D006801:Humans; D007477:Ions / Q000276:immunology / Q000378:metabolism*; D019255:NADPH Oxidases / Q000276:immunology*; D009504:Neutrophils / Q000201:enzymology* / Q000276:immunology; D017382:Reactive Oxygen Species / Q000378:metabolism; D015398:Signal Transduction / Q000276:immunology*
D007477:Ions; D017382:Reactive Oxygen Species; D019255:NADPH Oxidases