title: Conformational stability of Abeta-(25-35) in the presence of thiazolidine derivatives.
abstract: In the attempt to identify a new lead compound able to modify the conformational preferences of the beta-amyloid peptides, a set of new compounds characterized by a thiazolidine ring linked to several different aryl moieties were synthesized. The ability of these compounds to prevent the beta-amyloid aggregation was evaluated using circular dichroism and nuclear magnetic resonance techniques. Molecular docking procedure allowed an interpretation of spectroscopic in the key of molecular interaction.
authors: Dipartimento di Scienze Farmaceutiche, University of Salerno, 84084 Fisciano, Italy.
authors: Pietro
authors: P
authors: Campiglia
authors: Cinzia
authors: C
authors: Esposito
authors: Mario
authors: M
authors: Scrima
authors: Isabel
authors: I
authors: Gomez-Monterrey
authors: Alessia
authors: A
authors: Bertamino
authors: Paolo
authors: P
authors: Grieco
authors: Ettore
authors: E
authors: Novellino
authors: Anna Maria
authors: AM
authors: D'Ursi
mesh_terms: D016229:Amyloid beta-Peptides / Q000737:chemistry*; D002942:Circular Dichroism; D006801:Humans; D008958:Models, Molecular; D019906:Nuclear Magnetic Resonance, Biomolecular; D010455:Peptides / Q000737:chemistry*; D017433:Protein Structure, Secondary; D053778:Thiazolidines / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D016229:Amyloid beta-Peptides; D010455:Peptides; D053778:Thiazolidines