Good for Goose, but not for Gander: IL-2 interferes with Th17 differentiation.
In this issue of Immunity, Laurence et al. (2007) examined the effects of interleukin-2 on differentiation of the T helper 17 (Th17) cells and found that this essential growth factor for all other T cell subsets blocks the development of Th17 T cells.
Stockinger
Brigitta
B
Division of Molecular Immunology, The MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK. bstocki@nimr.mrc.ac.uk
D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D020381:Interleukin-17 / Q000378:metabolism*; D007376:Interleukin-2 / Q000494:pharmacology / Q000502:physiology*; D051379:Mice; D006377:T-Lymphocytes, Helper-Inducer / Q000187:drug effects / Q000276:immunology*
D020381:Interleukin-17; D007376:Interleukin-2