title: Improved dose targeting for a clinical epithermal neutron capture beam using optional (6)Li filtration.
abstract: OBJECTIVE
  The aim of this study was to construct a (6)Li filter and to improve penetration of thermal neutrons produced by the fission converter-based epithermal neutron beam (FCB) for brain irradiation during boron neutron capture therapy (BNCT).
  
  
  METHODS
  Design of the (6)Li filter was evaluated using Monte Carlo simulations of the existing beam line and radiation transport through an ellipsoidal water phantom. Changes in beam performance were determined using three figures of merit: (1) advantage depth (AD), the depth at which the total biologically weighted dose to tumor equals the maximum weighted dose to normal tissue; (2) advantage ratio (AR), the ratio of the integral tumor dose to that of normal tissue averaged from the surface to the AD; and (3) advantage depth dose rate (ADDR), the therapeutic dose rate at the AD. Dosimetry performed with the new filter installed provided calibration data for treatment planning. Past treatment plans were recalculated to illustrate the clinical potential of the filter.
  
  
  RESULTS
  The 8-mm-thick Li filter is more effective for smaller field sizes, increasing the AD from 9.3 to 9.9 cm, leaving the AR unchanged at 5.7 but decreasing the ADDR from 114 to 55 cGy min(-1) for the 12 cm diameter aperture. Using the filter increases the minimum deliverable dose to deep seated tumors by up to 9% for the same maximum dose to normal tissue.
  
  
  CONCLUSIONS
  Optional (6)Li filtration provides an incremental improvement in clinical beam performance of the FCB that could help to establish a therapeutic window in the future treatment of deep-seated tumors.
authors: Nuclear Reactor Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. binns@mit.edu
authors: Peter J
authors: PJ
authors: Binns
authors: Kent J
authors: KJ
authors: Riley
authors: Yakov
authors: Y
authors: Ostrovsky
authors: Wei
authors: W
authors: Gao
authors: J Raymond
authors: JR
authors: Albritton
authors: W S
authors: WS
authors: Kiger
authors: Otto K
authors: OK
authors: Harling
mesh_terms: D016754:Boron Neutron Capture Therapy / Q000295:instrumentation* / Q000379:methods; D016371:Cranial Irradiation / Q000295:instrumentation / Q000379:methods*; D004867:Equipment Design; D005374:Filtration / Q000295:instrumentation*; D006801:Humans; D008094:Lithium; D009010:Monte Carlo Method; D009502:Neutrons / Q000627:therapeutic use*; D019047:Phantoms, Imaging
chemical_list: D008094:Lithium