Bacterial translocation: overview of mechanisms and clinical impact.
Bacterial translocation (BT) is a phenomenon in which live bacteria or its products cross the intestinal barrier. Gut translocation of bacteria has been shown in both animal and human studies. BT and its complications have been shown clearly to occur in animal models, but its existence and importance in humans has been difficult to ascertain. We review the mechanisms of BT and its clinical impact based on the current literature.
Balzan
Silvio
S
Postgraduate Program, Gastroenterology Department, Digestive Surgery Division, University of Sao Paulo Medical School, Sao Paulo, Brazil. sbalzan@hotmail.com
de Almeida Quadros
Claudio
C
de Cleva
Roberto
R
Zilberstein
Bruno
B
Cecconello
Ivan
I
D000208:Acute Disease; D000818:Animals; D018988:Bacterial Translocation / Q000502:physiology; D005769:Gastrointestinal Motility / Q000502:physiology; D006801:Humans; D007165:Immunosuppression Therapy; D007413:Intestinal Mucosa / Q000473:pathology / Q000502:physiology; D007422:Intestines / Q000382:microbiology; D008103:Liver Cirrhosis / Q000503:physiopathology; D009102:Multiple Organ Failure / Q000503:physiopathology; D010195:Pancreatitis / Q000503:physiopathology; D018746:Systemic Inflammatory Response Syndrome / Q000503:physiopathology