[Gastroprotective effects of histamine H2-receptor blockers in Helicobacter-like gastric mucosa lesions].
This study was designed as a comparative experimental analysis of the gastroprotective effects of two H2-blocking agents--famotidine and benzimidazole compound 64--on the model rat stomach Helicobacter-like mucous lesions. Both substances demonstrated dose-dependent gastroprotective effects both on the macro- and microscopic levels. ED50 made up 21.8 mg/kg and 13.5 mg/kg, respectively.
Spasov
A A
AA
Chernikov
M V
MV
Speranskaia
A S
AS
Zaĭchenko
S I
SI
D000818:Animals; D004195:Disease Models, Animal; D015738:Famotidine / Q000627:therapeutic use*; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects* / Q000473:pathology; D016481:Helicobacter Infections / Q000150:complications*; D006635:Histamine H2 Antagonists / Q000627:therapeutic use*; D008297:Male; D009336:Necrosis; D051381:Rats; D013276:Stomach Ulcer / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology
D006635:Histamine H2 Antagonists; D015738:Famotidine