title: Impaired motor functions in mice lacking the RNA-binding protein Hzf.
abstract: Local protein synthesis in dendrites plays an important role in some aspects of neuronal development and synaptic plasticity. Neuronal RNA-binding proteins regulate the transport and/or translation of the localized mRNAs. Previously, we reported that hematopoietic zinc finger (Hzf) is one of the neuronal RNA-binding proteins that regulate these processes. The Hzf protein is highly expressed in neuronal cells including hippocampal pyramidal neurons and cerebellar Purkinje cells, and plays essential roles in the dendritic mRNA localization and translation. In the present study we demonstrated that mice lacking Hzf (Hzf(-/-) mice) exhibited severe impairments of motor coordination and cerebellum-dependent motor learning. These findings raise the possibility that the post-transcriptional regulation by Hzf may contribute to some aspects of synaptic plasticity and motor learning in the cerebellum.
authors: Department of Physiology, School of Medicine, Keio University, Shinjyuku, Tokyo 160-8582, Japan.
authors: Takatoshi
authors: T
authors: Iijima
authors: Hiroo
authors: H
authors: Ogura
authors: Kanako
authors: K
authors: Takatsuki
authors: Shigenori
authors: S
authors: Kawahara
authors: Kenichiro
authors: K
authors: Wakabayashi
authors: Daisuke
authors: D
authors: Nakayama
authors: Masato
authors: M
authors: Fujioka
authors: Yuki
authors: Y
authors: Kimura
authors: Alan
authors: A
authors: Bernstein
authors: Hirotaka James
authors: HJ
authors: Okano
authors: Yutaka
authors: Y
authors: Kirino
authors: Hideyuki
authors: H
authors: Okano
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D002526:Cerebellar Diseases / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology; D003214:Conditioning, Classical / Q000502:physiology; D007859:Learning Disabilities / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology; D008297:Male; D018782:Maze Learning / Q000502:physiology; D051379:Mice; D018345:Mice, Knockout; D009043:Motor Activity / Q000235:genetics; D019957:Motor Skills Disorders / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology; D010364:Pattern Recognition, Visual / Q000502:physiology; D011506:Proteins / Q000235:genetics*; D011930:Reaction Time / Q000235:genetics
chemical_list: D011506:Proteins; C404217:Zfp385 protein, mouse