Managing genital herpes infections in pregnancy.
Genital herpes is common and is becoming more so, with a seroprevalence of 25% in middle class primary care settings. Primary genital herpes in pregnancy most often is subclinical, but it also can cause severe illness. Further, active genital herpes at the time of vaginal delivery poses significant risk of neonatal infection, especially if the mother acquired the infection in the third trimester. It is important to prevent genital herpes acquisition in pregnancy and to diagnose recurrent genital herpes to prevent neonatal herpes.
Gardella
Carolyn
C
University of Washington Department of Obstetrics and Gynecology, Division of Women's Health, Seattle 98195-6460, USA. cgardel@u.washington.edu
Brown
Zane A
ZA
D000914:Antibodies, Viral / Q000032:analysis; D000998:Antiviral Agents / Q000627:therapeutic use*; D004279:DNA, Viral / Q000032:analysis; D003937:Diagnosis, Differential; D005260:Female; D006558:Herpes Genitalis / Q000175:diagnosis / Q000517:prevention & control / Q000821:virology; D006801:Humans; D016133:Polymerase Chain Reaction; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious; D011256:Pregnancy Outcome; D011379:Prognosis; D055502:Secondary Prevention; D018139:Simplexvirus / Q000235:genetics / Q000276:immunology
D000914:Antibodies, Viral; D000998:Antiviral Agents; D004279:DNA, Viral