title: Synthesis of 1,3- and 1,2-diphosphatidylglycerol.
abstract: A novel phosphonium salt methodology was utilized for the first time to synthesize 1,3-, and 1,2-diphosphatidylglycerol. Optically active 1,2-di-O-acyl-sn-glyceryl phosphate was coupled with unprotected glycerol in the presence of pyridiniumbromide perbromide and triethylamine to yield, after final removal of phosphate protecting group, the title compounds. The 1,2-diphosphatidylglycerol (1,2-isomer of cardiolipin) may be a member of a new class of phospholipids for industrial applications similar to other phosphocholines.
authors: NeoPharm, Inc., 1850 Lakeside Drive, Waukegan, IL 60085, USA.
authors: Moghis U
authors: MU
authors: Ahmad
authors: U Murali
authors: UM
authors: Krishna
authors: Shoukath M
authors: SM
authors: Ali
authors: Sreeti
authors: S
authors: Choudhury
authors: Imran
authors: I
authors: Ahmad
mesh_terms: D002308:Cardiolipins / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D009682:Magnetic Resonance Spectroscopy; D021241:Spectrometry, Mass, Electrospray Ionization; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D002308:Cardiolipins