Investigation on 1,4-dichlorophthalazine-derivatized cinchona alkaloids-catalyzed asymmetric "interrupted" Feist-Bénary reaction.
Different 1,4-dichlorophthalazine-cinchona alkaloid derivatives have been used to catalyze the asymmetric "interrupted" Feist-Bénary reaction of ethyl bromopyruvate/substituted bromoketoesters and beta-dicarbonyl compounds. The corresponding hydroxydihydrofurans have been obtained in excellent yields and with up to 91%ee.
Jin
Ying
Y
Research Center for Chirotechnology, The Fourth Military Medical University, Xi'an, Shaanxi, China.
Liu
Xue Ying
XY
Jing
Lin Lin
LL
He
Wei
W
Sun
Xiao Li
XL
Zhang
Sheng Yong
SY
D002384:Catalysis; D002930:Cinchona Alkaloids / Q000138:chemical synthesis / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism
D002930:Cinchona Alkaloids