[Selection of statin considering the HDL cholesterol level].
Low HDL cholesterol level is an independent risk factor in the cardivascular diseases and the therapeutic aim is to increase this. In high risk patients (cardiovascular disease-, diabetic- or metabolic syndrome patients), the target value of HDL cholesterol is more than 1,0 mmol/l in males and 1,3 mmol/l in females. The PPARalpha receptor activity has an expressed impact on the HDL cholesterol metabolism. It has been proved that in addition to fibrates, statins also influence its functioning. Simvastatin, as compared to atorvastatin, increases the HDL cholesterol level in a better way which positive effect has also been proved by the clinical trials. On choosing a therapy the optimisation of the HDL cholesterol level is also important in addition to achieving an LDL cholesterol target value.
Kalina
Akos
A
MAV Kórház és Központi Rendelointézet, Kardiológia, Budapest. kalinaak@t-online.hu
D000069059:Atorvastatin; D008076:Cholesterol, HDL / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D006538:Heptanoic Acids / Q000008:administration & dosage / Q000494:pharmacology; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage* / Q000494:pharmacology*; D008297:Male; D047493:PPAR alpha / Q000378:metabolism; D011758:Pyrroles / Q000008:administration & dosage / Q000494:pharmacology; D019821:Simvastatin / Q000008:administration & dosage / Q000494:pharmacology
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D006538:Heptanoic Acids; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D047493:PPAR alpha; D011758:Pyrroles; D000069059:Atorvastatin; D019821:Simvastatin