title: Determinants of coronary artery disease in nondiabetic hemodialysis patients: a matched case-control study.
abstract: OBJECTIVE
  The aim of this matched case-control study was to evaluate the determinants of coronary artery disease (CAD) other than conventional risk factors in nondiabetic hemodialysis (HD) patients.
  
  
  METHODS
  Among 312 consecutive patients on regular HD, 26 nondiabetic patients with angiographically defined coronary artery disease (20 men, 6 women; mean age 57.0 +/- 13 years) constituted the case group (group 1). A subject group of the same gender, smoking status, and hypertension with similar ages and body mass indexes who had normal electrocardiography and myocardial perfusion scintigraphy served as controls (20 men, 6 women; mean age 54.1+/-12 years, group 2). Demographics, high sensitivity C-reactive protein (hs-CRP), erythrocytes dimentation rate (ESR), hematocrit-corrected ESR, beta-2 microglobulin, cardiac troponin I, parathyroid hormone, albumin, calcium (Ca), phosphorus (P), Ca x P, and lipid profiles were compared between the groups.
  
  
  RESULTS
  Patients in group 1 had higher hs-CRP and troponin I (18.0+/-12 vs. 7.2+/-5 mg/L, p < 0.001; 0.36+/-0.16 vs. 0.22+/-0.05 ng/mL, p < 0.001, respectively) and lower HDL cholesterol levels than group 2 (37.0+/-10 mg/dL vs. 46.3+/-17 mg/dL, p = 0.02). Backwards stepwise logistic regression analysis revealed that high hs-CRP and troponin I levels (p = 0.03 and p = 0.01) and low HDL cholesterol levels (p = 0.02) were independently related with CAD.
  
  
  CONCLUSIONS
  According to these results, in nondiabetic patients on regular hemodialysis, high hs-CRP, troponin I levels and low HDL-cholesterol were the determinants of CAD.
authors: Department of Nephrology, Baskent University Faculty of Medicine, Ankara, Turkey. azumrutdal@yahoo.com
authors: Aysegul
authors: A
authors: Zumrutdal
authors: Mehmet
authors: M
authors: Baltali
authors: Hasan
authors: H
authors: Micozkadioglu
authors: Dilek
authors: D
authors: Torun
authors: Siren
authors: S
authors: Sezer
authors: F Nurhan
authors: FN
authors: Ozdemir
authors: Mehmet
authors: M
authors: Haberal
mesh_terms: D000328:Adult; D000368:Aged; D002097:C-Reactive Protein / Q000378:metabolism*; D016022:Case-Control Studies; D008076:Cholesterol, HDL / Q000097:blood*; D003324:Coronary Artery Disease / Q000097:blood* / Q000175:diagnosis / Q000209:etiology; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D019210:Troponin I / Q000097:blood*
chemical_list: D008076:Cholesterol, HDL; D019210:Troponin I; D002097:C-Reactive Protein