Delivery of retinoid-based therapies to target tissues.
Through its various metabolites, vitamin A controls essential physiological functions. Both naturally occurring metabolites and novel retinoid analogues have shown effectiveness in many clinical settings that include skin diseases and cancer, and in animal models of human conditions affecting vision. In this review, we analyze several potential retinoid-based therapies from the point of view of drug metabolism and transport to target tissues. We focus on the endogenous factors that affect the absorption, transport, and metabolism of retinoids by taking into account data obtained from the analysis of animal models that lack the enzymes or proteins involved in the storage and absorption of retinoids. We also discuss findings of toxicity associated with retinoids in an effort to improve the outcome of retinoid-based therapies. In this context, we review evidence that esterification of retinol and retinol-based drugs within target tissues provides one of the most efficient means to improve the absorption and to reduce the toxicity associated with pharmacological doses of retinoids. Future retinoid-based therapeutic strategies could involve targeted delivery mechanisms leading to lower toxicity and improved effectiveness of retinoids.
Moise
Alexander R
AR
Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106-4965, USA. ram50@case.edu
Noy
Noa
N
Palczewski
Krzysztof
K
Blaner
William S
WS
D000818:Animals; D006801:Humans; D007408:Intestinal Absorption; D008954:Models, Biological; D012176:Retinoids / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D012177:Retinol-Binding Proteins / Q000502:physiology; D014018:Tissue Distribution
D012176:Retinoids; D012177:Retinol-Binding Proteins