title: Micropapillary urothelial carcinoma of the renal pelvis: report of a case and review of the literature.
abstract: BACKGROUND
  Micropapillary urothelial carcinoma (MPUC) is a rare variant of urothelial carcinoma (UC), which is often advanced at presentation, and carries poor prognosis. Majority of the reported cases of MPUC originate from the urinary bladder. Of over 190 MPUC cases reported in the English literature, 35 cases were of the upper urinary tract. We report a rare case of MPUC of the renal pelvis.
  
  
  METHODS
  A 73-year old woman presented with hematuria. She had a mass in the left renal pelvis with massive infiltration in the renal parenchyma. She underwent surgery. Pathological stage was pT4N2M1. Although she received chemotherapy, she died of disease 14 months after operation. Histologically, MPUC was found in 40% of the tumor, mostly in the infiltrating portion. Immunohistochemically, MPUC showed intracytoplasmic expression of CK7 and CK20. Distinctive expression of MUC1 was observed on the stroma-forming surface of the neoplastic clusters in MPUC. Positive staining for p53 and negative staining for bcl-2 were remarkable. In the review of the literature, overall male predominance was remarkable (M:F=5.09:1), but it was less pronounced in the upper urinary tract (M:F=1.61:1).
  
  
  CONCLUSIONS
  Here we present a rare case of MPUC arising in the renal pelvis with thorough review of the literature.
authors: Department of Pathology, Sakai Municipal Hospital, Osaka, Japan. munakata-s@kanrou.net
authors: Satoru
authors: S
authors: Munakata
authors: Hideo
authors: H
authors: Tahara
authors: Keiko
authors: K
authors: Kojima
authors: Tomomi
authors: T
authors: Kishimoto
mesh_terms: D000368:Aged; D002291:Carcinoma, Papillary / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007564:Japan; D007680:Kidney Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D014516:Ureteral Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery