Antiradical effect of allopurinol at early stages of experimental acute pancreatitis.
Pretreatment with allopurinol partly prevented generation of free oxygen radicals in the pancreas of dogs with experimental acute pancreatitis. Allopurinol holds promise for the prevention of acute postoperative pancreatitis.
Shabanov
V V
VV
Department and Clinics of Surgery, Samara Military Medical Institute. vmedi@sama.ru
Milyakova
M N
MN
Minyailov
N A
NA
D000493:Allopurinol / Q000378:metabolism* / Q000627:therapeutic use; D000818:Animals; D004285:Dogs; D004586:Electrophoresis; D016166:Free Radical Scavengers / Q000378:metabolism* / Q000627:therapeutic use*; D010179:Pancreas / Q000187:drug effects; D010195:Pancreatitis / Q000517:prevention & control*; D051381:Rats; D017382:Reactive Oxygen Species / Q000378:metabolism*; D018709:Statistics, Nonparametric; D013482:Superoxide Dismutase / Q000378:metabolism
D016166:Free Radical Scavengers; D017382:Reactive Oxygen Species; D000493:Allopurinol; D013482:Superoxide Dismutase