Collagen-apatite nanocomposite membranes for guided bone regeneration.
Collagen-apatite nanocomposite is regarded as a potential biomaterial because of its composition and structure, which are similar to those of human hard tissues. However, there have been few investigations of its mechanical and biological benefits in direct comparison with a collagen equivalent. Herein, we successfully produced a biomedical membrane made of a nanocomposite, and systemically evaluated the mechanical, chemical, and biological properties of the nanocomposite in comparison with those of pure collagen. The results showed that significant improvements were achieved by the nanocomposite approach, particularly in terms of the mechanical strength and chemical stability. The present findings point to the potential usefulness of the collagen-apatite nanocomposite membrane in the field of guided bone regeneration (GBR).
Song
Ju-Ha
JH
School of Materials Science and Engineering, Seoul National University, Seoul 151-744, Korea.
Kim
Hyoun-Ee
HE
Kim
Hae-Won
HW
D016475:3T3 Cells; D000818:Animals; D001031:Apatites / Q000737:chemistry* / Q000378:metabolism; D001672:Biocompatible Materials / Q000737:chemistry* / Q000378:metabolism; D001861:Bone Regeneration / Q000502:physiology*; D002417:Cattle; D002470:Cell Survival; D003094:Collagen / Q000737:chemistry* / Q000378:metabolism; D004795:Enzyme Stability; D048091:Guided Tissue Regeneration; D006801:Humans; D008422:Materials Testing; D051379:Mice; D053761:Nanocomposites; D013314:Stress, Mechanical; D013499:Surface Properties
D001031:Apatites; D001672:Biocompatible Materials; D003094:Collagen