Division of labor: specialization of sphingosine kinases in mast cells.
Generation of sphingosine-1-phosphate by sphingosine kinases (SphKs) promotes allergic inflammatory diseases, but the roles of the individual SphK isoforms are unclear. Olivera et al. (2007) show that SphK2 regulates mast cell activation whereas SphK1 enhances susceptibility to antigen challenge in vivo.
Beaven
Michael A
MA
National Heart, Lung, and Blood Institute, National Institutes of Health, Room 8N109/Bldg. 10, Bethesda, MD 20892, USA. beavenm@nhlbi.nih.gov
D000818:Animals; D000941:Antigens / Q000276:immunology; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000201:enzymology / Q000276:immunology; D008407:Mast Cells / Q000201:enzymology* / Q000276:immunology*; D051379:Mice; D017853:Phosphotransferases (Alcohol Group Acceptor) / Q000502:physiology*; D000099157:Sphingosine Kinase
D000941:Antigens; D017853:Phosphotransferases (Alcohol Group Acceptor); D000099157:Sphingosine Kinase