Limitations of the "tethering" strategy for the detection of a weak noncovalent interaction.
The success of applying the tethering strategy in a synthetic molecular system strongly depends on the experimental conditions and is related to the strength of the noncovalent interaction and the competition between the 'captured' and unbound ligand for the recognition site.
Gasparini
Giulio
G
Department of Chemical Sciences and CNR ITM Padova Section, University of Padova, via Marzolo 1, I-35131, Padova, Italy.
Martin
Marco
M
Prins
Leonard J
LJ
Scrimin
Paolo
P