title: Cerebral embolism with interventional closure of symptomatic patent foramen ovale: an MRI-based study using diffusion-weighted imaging.
abstract: Paradoxical embolism via patent foramen ovale (PFO) is an important cause of stroke, especially in younger patients. Transcatheter PFO closure is considered to bear a low risk and to be technically feasable with a high primary success rate. There are no data for the rate of procedure-associated silent embolic events. The present study sought to analyze the total number of cerebral ischemic complications with interventional PFO closure. Thirty-five symptomatic PFO patients (15 male, 26-71 years) with cerebral infarctions proven by magnetic resonance imaging (MRI) were examined by diffusion-weighted imaging (DWI) before and after PFO closure. In the MRI examinations following the intervention, new microembolic lesions were found in three of 35 (8.6%) patients. The lesions were located in the right and left thalamus and the left frontoparietal white matter respectively. Two of three infarcts were clinically inapparent, whereas the third patient suffered from a transient right-sided hemihypaesthesia for 12 h. If the prevention of recurrent cerebrovascular events associated with the presence of PFO is necessary, a low frequency of closure associated silent cerebral embolisms was documented after interventional PFO closure. The rate of microembolic events with neurological deficit was 1/35 (approximately 2.8%).
authors: Department of Radiology, University of Bonn, Bonn, Germany. ulrich.dorenbeck@ukb.uni-bonn.de
authors: U
authors: U
authors: Dorenbeck
authors: B
authors: B
authors: Simon
authors: D
authors: D
authors: Skowasch
authors: C
authors: C
authors: Stüsser
authors: A
authors: A
authors: Gockel
authors: H H
authors: HH
authors: Schild
authors: H
authors: H
authors: Urbach
authors: G
authors: G
authors: Bauriedel
mesh_terms: D000328:Adult; D000368:Aged; D006328:Cardiac Catheterization / Q000009:adverse effects; D006348:Cardiac Surgical Procedures / Q000009:adverse effects*; D038524:Diffusion Magnetic Resonance Imaging; D006344:Heart Septal Defects, Atrial / Q000601:surgery*; D006801:Humans; D020766:Intracranial Embolism / Q000209:etiology*; D008297:Male; D008875:Middle Aged