title: Body iron is a contributor to oxidative damage of DNA.
abstract: The transition metal iron is catalytically highly active in vitro, and not surprisingly, body iron has been suggested to promote oxidative stress in vivo. In the current analysis we studied the association of serum ferritin concentration and serum soluble transferrin receptor concentration with daily urinary 8-hydroxydeoxyguanosine excretion, a marker of oxidative stress, in 48 mildly dyslipidemic men in East Finland. In multivariate linear regression analyses allowing for age, smoking, body mass index and physical exercise, serum ferritin concentration predicted the excretion rate at B = 0.17 (95% CI 0.08-0.26, P = 0.001), and serum soluble transferrin receptor to ferritin concentration ratio (TfR/ferritin) predicted the excretion rate at B = - 0.13 (95% CI - 0.21 to - 0.05, P = 0.002). Our data suggest that body iron contributes to excess oxidative stress already at non-iron overload concentrations in these subjects.
authors: Research Institute of Public Health, School of Public Health and Clinical Nutrition, University of Kuopio, Finland.
authors: Tomi-Pekka
authors: TP
authors: Tuomainen
authors: Steffen
authors: S
authors: Loft
authors: Kristiina
authors: K
authors: Nyyssönen
authors: Kari
authors: K
authors: Punnonen
authors: Jukka T
authors: JT
authors: Salonen
authors: Henrik E
authors: HE
authors: Poulsen
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D001823:Body Composition; D004247:DNA / Q000378:metabolism; D004249:DNA Damage; D003849:Deoxyguanosine / Q000031:analogs & derivatives / Q000652:urine; D005260:Female; D005293:Ferritins / Q000097:blood*; D006801:Humans; D006937:Hypercholesterolemia / Q000378:metabolism*; D007501:Iron / Q000032:analysis / Q000097:blood*; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D011990:Receptors, Transferrin / Q000097:blood*; D014018:Tissue Distribution
chemical_list: D011990:Receptors, Transferrin; D000080242:8-Hydroxy-2'-Deoxyguanosine; D004247:DNA; D005293:Ferritins; D007501:Iron; D003849:Deoxyguanosine