title: Reproducibility of ambulatory blood pressure monitoring in hypertensive patients with type 2 diabetes mellitus.
abstract: OBJECTIVE
  To evaluate the reproducibility of ambulatory blood pressure monitoring (ABPM) (SpaceLabs-90207) and placebo effect on ABPM.
  
  
  METHODS
  Blood pressure was measured in the office and over two ABPM periods with an interval from one to ten months (mean 4.9 months), in 26 patients with type 2 diabetes mellitus and hypertension. Eleven patients (G1) had two ABPMs without taking antihypertensive drugs for 15 days, whereas G2 (N=15) had the second ABPM after administration of a placebo for 15 days.
  
  
  RESULTS
  In the evaluation of the coefficient of variation (CV) of diurnal (awake) systolic BP (DSBP), of diurnal (awake) diastolic BP (DDBP), of 24-hour systolic BP (24hSBP) and of 24-hour diastolic BP (24hDBP), the values found were 4.6%, 3.9%, 5.0%, 4.0% for G1 and 4.3%, 5.1%, 3.7%, 5.1% for G2 respectively. We also determined the CV of nocturnal (sleep) systolic and diastolic BP (NSBP and NDBP) for G1 (7.7%; 8.2%) and G2 (5.6%; 6.3%). Heart rate CV during alertness and sleep were: G1=5.9% and 9.0%; G2=6.9% and 5.8% respectively. When the total number of 'patients was analyzed, all variables showed a strong correlation between the first and second ABPM measurements (DSBP, r = 0.76; P < 0.001; DDBP, r = 0.65; p < 0.001; 24hSBP, r = 0.77; p < 0.001; 24hDBP, r = 0.70; p < 0.001; NSBP, r = 0.62; p < 0.001; NDBP, r = 0.52; p < 0.01). Office systolic and diastolic BP and 24hSBP and 24hDBP also showed correlation (r = 0.65; p < 0.001; r = 0.57; p < 0.01).
  
  
  CONCLUSIONS
  Mean of pressure levels measured by ABPM presented good reproducibility and were not affected by placebo.
authors: Divisão de Nefrologia e Endocrinologia, UNIFESP, São Paulo, SP, Brazil. felicio.bel@terra.com.br
authors: João Soares
authors: JS
authors: Felício
authors: Juliana Torres
authors: JT
authors: Pacheco
authors: Sandra Roberta
authors: SR
authors: Ferreira
authors: Frida
authors: F
authors: Plavnik
authors: Oswaldo
authors: O
authors: Kohlmann
authors: Artur Beltrame
authors: AB
authors: Ribeiro
authors: Maria Tereza
authors: MT
authors: Zanella
mesh_terms: D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000008:administration & dosage; D018660:Blood Pressure Monitoring, Ambulatory / Q000379:methods*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D003925:Diabetic Angiopathies / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D006973:Hypertension / Q000175:diagnosis* / Q000188:drug therapy; D008875:Middle Aged; D015990:Placebo Effect; D015203:Reproducibility of Results; D013997:Time Factors
chemical_list: D000959:Antihypertensive Agents