title: Targeting the RAF/MEK/ERK, PI3K/AKT and p53 pathways in hematopoietic drug resistance.
authors: Department of Microbiology & Immunology, Brody School of Medicine at East Carolina University Greenville, NC 27858, USA. mccubreyj@ecu.edu
authors: James A
authors: JA
authors: McCubrey
authors: Linda S
authors: LS
authors: Steelman
authors: Richard A
authors: RA
authors: Franklin
authors: Steven L
authors: SL
authors: Abrams
authors: William H
authors: WH
authors: Chappell
authors: Ellis W T
authors: EW
authors: Wong
authors: Brian D
authors: BD
authors: Lehmann
authors: David M
authors: DM
authors: Terrian
authors: Jorg
authors: J
authors: Basecke
authors: Franca
authors: F
authors: Stivala
authors: Massimo
authors: M
authors: Libra
authors: Camilla
authors: C
authors: Evangelisti
authors: Alberto M
authors: AM
authors: Martelli
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D045744:Cell Line, Tumor; D016503:Drug Delivery Systems / Q000379:methods; D019008:Drug Resistance, Neoplasm / Q000502:physiology*; D048049:Extracellular Signal-Regulated MAP Kinases / Q000037:antagonists & inhibitors / Q000096:biosynthesis / Q000235:genetics; D019337:Hematologic Neoplasms / Q000188:drug therapy* / Q000201:enzymology / Q000378:metabolism; D051379:Mice; D020929:Mitogen-Activated Protein Kinase Kinases / Q000037:antagonists & inhibitors / Q000096:biosynthesis / Q000235:genetics; D019869:Phosphatidylinositol 3-Kinases / Q000096:biosynthesis / Q000235:genetics; D000081082:Phosphoinositide-3 Kinase Inhibitors; D051057:Proto-Oncogene Proteins c-akt / Q000037:antagonists & inhibitors / Q000096:biosynthesis / Q000235:genetics; D015398:Signal Transduction / Q000187:drug effects* / Q000502:physiology; D016159:Tumor Suppressor Protein p53 / Q000037:antagonists & inhibitors / Q000096:biosynthesis / Q000235:genetics; D048490:raf Kinases / Q000037:antagonists & inhibitors* / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D048049:Extracellular Signal-Regulated MAP Kinases; D020929:Mitogen-Activated Protein Kinase Kinases; D019869:Phosphatidylinositol 3-Kinases; D000081082:Phosphoinositide-3 Kinase Inhibitors; D051057:Proto-Oncogene Proteins c-akt; D016159:Tumor Suppressor Protein p53; D048490:raf Kinases