title: Interleukin-1 alpha genotype and outcome of unrelated donor haematopoietic stem cell transplantation for chronic myeloid leukaemia.
abstract: Interleukin-1 alpha (IL-1alpha) is a pro-inflammatory cytokine that is implicated in the initiation/maintenance of graft-versus-host disease (GVHD) and the immune response to infection. A cytosine (C) to thymine (T) transition at position -889 is believed to influence gene transcription. A previous single institution study showed that the presence of at least one IL1A T allele in the donor was associated with improved survival after unrelated donor haematopoietic stem cell transplant and lower transplant-related mortality if the donor and recipient each possessed the IL1A T allele. The present study sought to confirm these results in a larger homogeneous population. Thus the study population included 426 patients older than 18 years with chronic myeloid leukaemia (CML), transplanted in first chronic phase and receiving a total body irradiation and cyclophosphamide preparative regimen. Donor recipient pairs were categorised into four groups according to the presence or absence of an IL1A T allele in the donor and recipient. There were no significant differences in patient, donor and transplant characteristics between the groups. We did not observe an association with IL-1alpha genotype in donor and/or recipient and transplant-outcome. These data suggest that the outcome of unrelated donor transplant for CML is not influenced by IL-1alpha genotype.
authors: Division of Haematology Oncology, Cincinnati Children's Hospital and Medical Center, Cincinnati, OH 45229, USA. parinda.Mehta@cchmc.org
authors: Parinda A
authors: PA
authors: Mehta
authors: Mary
authors: M
authors: Eapen
authors: John P
authors: JP
authors: Klein
authors: Sharavi
authors: S
authors: Gandham
authors: James
authors: J
authors: Elliott
authors: Tiffany
authors: T
authors: Zamzow
authors: Michelle
authors: M
authors: Combs
authors: Richard
authors: R
authors: Aplenc
authors: Margaret L
authors: ML
authors: MacMillan
authors: Daniel J
authors: DJ
authors: Weisdorf
authors: Effie
authors: E
authors: Petersdorf
authors: Stella M
authors: SM
authors: Davies
mesh_terms: D000293:Adolescent; D000328:Adult; D000483:Alleles; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006086:Graft vs Host Disease / Q000209:etiology / Q000517:prevention & control; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects; D006650:Histocompatibility Testing; D006801:Humans; D053582:Interleukin-1alpha / Q000235:genetics*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011379:Prognosis; D012008:Recurrence; D016896:Treatment Outcome
chemical_list: D053582:Interleukin-1alpha