title: Antitumor and antimetastatic effects of betulonic acid amides in mice with transplantable lewis carcinoma.
abstract: We studied the effects of four synthetic amides of betulonic acid containing amino acid fragments (d,l-alpha-alanine, beta-alanine, and their methyl esters) on the rate of growth and metastatic dissemination of transplantable Lewis lung carcinoma in C57Bl/6 mice. The test compounds were administered intragastrically in a single dose of 500 mg/kg. 3-[-oxo-20(29)-lupen-28-oilamino]-propionic acid suppressed primary tumor growth (by 26%) and decreased the number of lung metastases (by more than 2 times). Antitumor and antimetastatic activity of triterpenoids decreased after methylation of the amino acid fragment in betulonic acid.
authors: Laboratory of Pharmacological Studies, N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Division of the Russian Academy of Sciences. sorokina@nioch.nsc.ru
authors: I V
authors: IV
authors: Sorokina
authors: T G
authors: TG
authors: Tolstikova
authors: N A
authors: NA
authors: Zhukova
authors: N I
authors: NI
authors: Petrenko
authors: N V
authors: NV
authors: Uzenkova
authors: E E
authors: EE
authors: Shul'ts
authors: N A
authors: NA
authors: Popova
mesh_terms: D000409:Alanine / Q000737:chemistry; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000627:therapeutic use*; D018827:Carcinoma, Lewis Lung / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009362:Neoplasm Metastasis / Q000473:pathology / Q000517:prevention & control*; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000627:therapeutic use; D000094062:Betulinic Acid
chemical_list: D000409:Alanine; D000970:Antineoplastic Agents; D009828:Oleanolic Acid; C508784:(3-oxo-20(29)-lupene-28-oyl)-3-aminopropionamide; D000094062:Betulinic Acid