Silent ACTH cell adenoma in coincidence with granulomatous hypophysitis--a case report.
A 44-year-old male suffered from an inactive pituitary adenoma measuring 20mm in computed tomography (CT) scan and nuclear magnetic resonance tomography (NMR). The tumor was surgically resected via the transnasal-transsphenoidal route. Surgical specimens revealed a typical, sparsely granulated adrenocorticotropic hormone (ACTH) cell adenoma, but also a granulomatous inflammation mostly in the periphery of the tumor, corresponding to a granulomatous hypophysitis. This coincidence appears to be unique and has yet not been described in the literature. Therefore, the clinical data and the pathohistologic and ultrastructural findings are presented here.
Saeger
Wolfgang
W
Institute of Pathology of the Marienkrankenhaus Hamburg, Hamburg, Germany. saeger.patho@marienkrankenhaus.org
Hofmann
Bernd M
BM
Buslei
Rolf
R
Buchfelder
Michael
M
D049913:ACTH-Secreting Pituitary Adenoma / Q000150:complications* / Q000648:ultrastructure*; D000236:Adenoma / Q000150:complications* / Q000648:ultrastructure*; D000328:Adult; D002545:Brain Ischemia / Q000150:complications; D006099:Granuloma / Q000150:complications / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D033162:Incidental Findings; D008279:Magnetic Resonance Imaging; D008297:Male; D046529:Microscopy, Electron, Transmission; D010900:Pituitary Diseases / Q000150:complications* / Q000473:pathology*; D014057:Tomography, X-Ray Computed