On-chip erythrocyte deformability test under optical pressure.
This paper presents a novel method for an on-chip erythrocyte deformability test under optical pressure, especially to enhance the level of sensitivity with respect to the detection of cancerous diseases. To demonstrate the performance and sensitivity of the combined method, we introduce the concept of transit velocity, a modified elongation index, and shape recovery time of individual erythrocytes in a strictly confined region (2 microm deep, 4 microm wide, and 100 microm long). Finally, we investigate a synergy or convergence effect due to the combination of these parameters for in situ detection of cancerous diseases under optical pressure.
Lee
Won Gu
WG
School of Mechanical and Aerospace Engineering, Seoul National University, San 56-1 Shinlim, Kwanak, Seoul 151-742, South Korea.
Bang
Hyunwoo
H
Yun
Hoyoung
H
Lee
Joonmo
J
Park
Junha
J
Kim
Jung Kyung
JK
Chung
Seok
S
Cho
Keunchang
K
Chung
Chanil
C
Han
Dong-Chul
DC
Chang
Jun Keun
JK
D000328:Adult; D004548:Elasticity; D004903:Erythrocyte Aggregation; D004907:Erythrocyte Deformability; D004912:Erythrocytes / Q000166:cytology*; D006801:Humans; D009369:Neoplasms / Q000097:blood / Q000175:diagnosis; D055095:Optics and Photonics; D011312:Pressure; D012680:Sensitivity and Specificity; D013997:Time Factors