Exercise and colon cancer: primary and secondary prevention.
Many studies have demonstrated the effects of exercise on both primary and secondary prevention of colon cancer. Exercise appears to have a dose-response reduction in the rate of colon cancer. The mechanism by which exercise provides this benefit is not known, but increase in insulin-like growth factor-binding protein and reduction of prostaglandins appear to be the likely cause. Once a person develops colon cancer the benefits of exercise appear to continue both by increasing quality of life and reducing cancer-specific and overall mortality.
Trojian
Thomas H
TH
University of Connecticut Health Center/Saint Francis Hospital and Medical Center, Department of Family Medicine, Hartford, CT 06105, USA. ttrojian@stfranciscare.org
Mody
Ketan
K
Chain
Philippe
P
D003110:Colonic Neoplasms / Q000453:epidemiology* / Q000517:prevention & control*; D005081:Exercise Therapy / Q000379:methods* / Q000706:statistics & numerical data*; D006801:Humans; D015994:Incidence; D010809:Physical Fitness; D011322:Primary Prevention / Q000379:methods*; D040242:Risk Reduction Behavior; D016896:Treatment Outcome; D014481:United States