title: Synthesis and biological evaluation of 5-substituted 1,4-dihydroindeno[1,2-c]pyrazoles as multitargeted receptor tyrosine kinase inhibitors.
abstract: We report the synthesis and biological evaluation of 5-substituted 1,4-dihydroindeno[1,2-c]pyrazoles as multitargeted kinase inhibitors. Initial efforts focused on the development of selective KDR inhibitors, while later strategies involved the improvement of potency toward multiple kinase targets. Thus, several compounds were identified as potent KDR, Flt1, Flt3, and c-Kit inhibitors.
authors: Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60044, USA. irini.zanze@abbott.com
authors: Irini
authors: I
authors: Akritopoulou-Zanze
authors: Daniel H
authors: DH
authors: Albert
authors: Peter F
authors: PF
authors: Bousquet
authors: George A
authors: GA
authors: Cunha
authors: Christopher M
authors: CM
authors: Harris
authors: Maria
authors: M
authors: Moskey
authors: Jurgen
authors: J
authors: Dinges
authors: Kent D
authors: KD
authors: Stewart
authors: Thomas J
authors: TJ
authors: Sowin
mesh_terms: D000818:Animals; D006801:Humans; D015394:Molecular Structure; D047428:Protein Kinase Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D011720:Pyrazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D020794:Receptor Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors*
chemical_list: D047428:Protein Kinase Inhibitors; D011720:Pyrazoles; D020794:Receptor Protein-Tyrosine Kinases