title: Cytotoxic kurubasch aldehyde from Trichilia emetica.
abstract: Kurubasch aldehyde, a sesquiterpenoid with an hydroxylated humulene skeleton, was isolated as free alcohol from Trichilia emetica Vahl. (Meliaceae), belonging to the order Sapindales. Related substances have been previously found in plants as esters of aromatic acids, and these plants were species belonging to the distant order Apiales. This is the first report of humulenes found in the genus Trichilia and only the second of humulenes in the order Sapindales. The aldehyde is a modest inhibitor of the growth of Plasmodium falciparum (IC50 76 microM) and slow-proliferating breast cancer cells MCF7 (78 microM), but a potent inhibitor of proliferation of S180 cancer cells (IC50 7.4 microM).
authors: Direction Regionale de Institut de Recherche en Sciences de la Santé, Bobo-Dioulasso, Burkina Faso.
authors: Maminata
authors: M
authors: Traore
authors: Lin
authors: L
authors: Zhai
authors: Ming
authors: M
authors: Chen
authors: Carl Erik
authors: CE
authors: Olsen
authors: Nacoulma
authors: N
authors: Odile
authors: Guissou I
authors: GI
authors: Pierre
authors: Ouédrago J
authors: OJ
authors: Bosco
authors: Guigemdé T
authors: GT
authors: Robert
authors: S Brøgger
authors: SB
authors: Christensen
mesh_terms: D000447:Aldehydes / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D006801:Humans; D013058:Mass Spectrometry; D029582:Meliaceae / Q000737:chemistry*; D051379:Mice; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009904:Optical Rotation; D018517:Plant Roots / Q000737:chemistry; D010963:Plasmodium falciparum / Q000187:drug effects; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000447:Aldehydes; D000962:Antimalarials; D000972:Antineoplastic Agents, Phytogenic; D012717:Sesquiterpenes