Comparison between Alpha and silver sulfadiazine ointments in treatment of Pseudomonas infections in 3rd degree burns.
The goal of this study was to evaluate the efficacy of Alpha ointment in the treatment of burn wounds and compare its results with silver sulfadiazine (SS). Similar burn ulcers were produced on anterior surface of thigh of 60 rats. The wounds were infected with Pseudomonas aeruginosa and dressing and debridement was performed daily. The first group of rats received topical SS, the second group received Alpha ointment and the third (control group) received no medication. Wound healing, contraction, culture, and scar formation were evaluated at the end of the second and 10th week. Alpha ointment was equally effective as SS, considering wound healing and contraction. Wound infection was significantly less common in Alpha ointment group compared to the other two groups (p<0.05). Alpha ointment is a less expensive drug with an acceptable result compared to SS. Therefore, we recommend it as an alternative to SS, especially in patients with low economical backgrounds or in those who show adverse reactions to SS.
Hosseini
Seyed V
SV
Gastroenterohepatology Research Center, Department of Surgery, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
Tanideh
Nader
N
Kohanteb
Jamshid
J
Ghodrati
Zahra
Z
Mehrabani
Davood
D
Yarmohammadi
Hooman
H
D000287:Administration, Topical; D000818:Animals; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage; D001458:Bandages; D002056:Burns / Q000150:complications*; D003646:Debridement; D004195:Disease Models, Animal; D009824:Ointments / Q000008:administration & dosage*; D011552:Pseudomonas Infections / Q000188:drug therapy* / Q000209:etiology; D011550:Pseudomonas aeruginosa; D051381:Rats; D012837:Silver Sulfadiazine / Q000008:administration & dosage*; D014945:Wound Healing / Q000187:drug effects; D014946:Wound Infection / Q000188:drug therapy* / Q000209:etiology / Q000382:microbiology
D000891:Anti-Infective Agents, Local; D009824:Ointments; D012837:Silver Sulfadiazine