title: Homology modelling and conformational analysis of IgE-binding epitopes of Ara h 3 and other legumin allergens with a cupin fold from tree nuts.
abstract: Linear IgE-binding epitopes identified in legumin allergens of peanut (Ara h 3) and other allergenic tree nuts (Jug r 4 of walnut, Cor a 9 of hazelnut, Ana o 2 cashew nut) were mapped on three-dimensional models of the proteins built up by homology modelling. A conformational analysis revealed that consensual surface-exposed IgE-binding epitopes exhibited some structural homology susceptible to account for the IgE-binding cross-reactivity observed among peanut and tree nut allergens. This structurally related cross-reactivity seems irrespective of the botanical origin of the allergens and thus demands that persons allergic to peanut avoid other three nuts to prevent possible allergic reactions. IgE-binding epitopes similar to those found in 11S globulin allergens do not apparently occur in other vicilin allergens with the cupin fold from peanut (Ara h 1) or tree nuts (Jug r 2 of walnut, Cor a 1 of hazel nut, Ana o 3 of cashew nut).
authors: Surfaces Cellulaires et Signalisation chez les Végétaux, UMR UPS-CNRS 5546, 24 Chemin de Borde Rouge, 31326 Castanet Tolosan, France.
authors: Annick
authors: A
authors: Barre
authors: Geraldine
authors: G
authors: Jacquet
authors: Camille
authors: C
authors: Sordet
authors: Raphaël
authors: R
authors: Culerrier
authors: Pierre
authors: P
authors: Rougé
mesh_terms: D000485:Allergens / Q000737:chemistry*; D052179:Antigens, Plant / Q000737:chemistry*; D000939:Epitopes / Q000737:chemistry*; D007073:Immunoglobulin E / Q000276:immunology*; D008958:Models, Molecular; D021184:Nut Hypersensitivity / Q000276:immunology; D009754:Nuts / Q000276:immunology; D011487:Protein Conformation; D055314:Seed Storage Proteins; D040681:Structural Homology, Protein
chemical_list: D000485:Allergens; D052179:Antigens, Plant; D000939:Epitopes; D055314:Seed Storage Proteins; C118207:allergen Ara h3; D007073:Immunoglobulin E