Allergic reactions in patients suffering from asthma induced by house dust mites which treatment by juvenile hormone.
The effect of Juvenile hormone analogue, Admiral "pyriproxyfen", which acts as a protein de-naturing agent, on the protein patterns of D. farinae was studied on allergic reactions in patients with HDM asthma, and in mice injected twice (within 10 days) with mite crude extracts. Total protein concentrations and protein patterns were different in normal and admiral-treated mites. This may result in reducing the allergenic of treated mites. Histamine release, total immunoglobulin E (IgE), specific immunoglobulin E (S-IgE), eosinophil cationic protein (ECP), and absolute eosinophil count (AEC) were determined for moderate and severe HDM asthma-tics compared to check cases. These parameters had higher levels in asthmatic patients than in normal (check) individuals. Injection of mice with normal adult extracts of D. farinae resulted in significantly higher levels of histamine, S-IgE and ECP than in the check animals. Skin reactions were observed in all of the mice injected with normal or treated D. farinae extracts.
Mazyad
Said A M
SA
Research and Training Center on Vectors of Diseases, Ain Shams University, Cairo 11566, Egypt.
Mohammad
Khairy A
KA
Khalil
Hazem H M
HH
D000293:Adolescent; D000818:Animals; D001249:Asthma / Q000188:drug therapy*; D002648:Child; D002675:Child, Preschool; D047150:Eosinophil Cationic Protein / Q000276:immunology; D004804:Eosinophils / Q000276:immunology; D005260:Female; D006636:Histamine Release / Q000276:immunology; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology; D007223:Infant; D008297:Male; D051379:Mice; D011725:Pyridines / Q000627:therapeutic use*; D039981:Pyroglyphidae / Q000276:immunology*
D011725:Pyridines; D007073:Immunoglobulin E; C055613:pyriproxyfen; D047150:Eosinophil Cationic Protein