Lectin-like oxidized low-density lipoprotein receptor-1: protein, ligands, expression and pathophysiological significance.
OBJECTIVE
To review the recent research progress in lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) including its protein, ligands, expression and pathophysiological significance. Data sources Information included in this article was identified by searching of PUBMED (1997 - 2006) online resources using the key term LOX-1.


METHODS
Mainly original milestone articles and critical reviews written by major pioneer investigators of the field were selected.


RESULTS
The key issues related to the LOX-1 protein as well as ligands for LOX-1. Factors regulating the expression of LOX-1 were summarized. The pathophysiological functions of LOX-1 in several diseases were discussed.


CONCLUSIONS
Identification of LOX-1 and a definition of its biological role in pathophysiologic states provide deeper insight into the pathogenesis of some cardiovascular diseases especially in atherosclerosis and provide a potential selective therapeutic approach. LOX-1 is unlocking and drugs targeting LOX-1 might be a promising direction to explore.
Chen
Xiu-ping
XP
Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
DU
Guan-hua
GH
D000818:Animals; D001172:Arthritis, Rheumatoid / Q000209:etiology; D050197:Atherosclerosis / Q000209:etiology; D006801:Humans; D008024:Ligands; D009203:Myocardial Infarction / Q000209:etiology; D010003:Osteoarthritis / Q000209:etiology; D051127:Scavenger Receptors, Class E / Q000737:chemistry / Q000235:genetics / Q000502:physiology*
D008024:Ligands; D051127:Scavenger Receptors, Class E