Tumour biology and histopathology of neuroendocrine tumours.
The tumours of the disseminated/diffuse neuroendocrine cell system are a group of neoplasms sharing uniformly appearing cells which differ from each other in their biology, prognosis and genetics. In the lung they are called carcinoid and small/large-cell neuroendocrine carcinomas. In the gastroenteropancreatic compartment they are classified as well-differentiated neuroendocrine tumours or carcinomas and poorly differentiated neuroendocrine carcinomas. Depending on their localization these neoplasms reveal distinct phenotypes with respect to pathology, immunohistochemistry, and hormonal syndromes. Their clinical behaviour--ranging from benign and low-grade to high-grade malignancy--can be predicted on the basis of clinicopathological criteria. Currently extensive work is being performed to unravel the genetic background.
Klöppel
Günter
G
Department of Pathology, University of Kiel, Michaelisstr. 11, 24105 Kiel, Germany. guenterkloeppel@path.uni-kiel.de
D015415:Biomarkers / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis; D002277:Carcinoma / Q000145:classification / Q000175:diagnosis / Q000235:genetics / Q000473:pathology; D005770:Gastrointestinal Neoplasms / Q000145:classification / Q000175:diagnosis / Q000235:genetics / Q000473:pathology; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D018358:Neuroendocrine Tumors / Q000145:classification / Q000175:diagnosis / Q000235:genetics / Q000473:pathology*; D009490:Neurosecretory Systems / Q000166:cytology; D011379:Prognosis; D012142:Respiratory Tract Neoplasms / Q000145:classification / Q000175:diagnosis / Q000235:genetics / Q000473:pathology
D015415:Biomarkers; D014408:Biomarkers, Tumor