Role of cannabinoid receptor agonists in mechanisms of suppression of central pain syndrome.
We studied the effect of cannabinoid receptor agonists anandamide and WIN 55,212-2 on the central pain syndrome induced by intraspinal injection of penicillin sodium salt in rats. Cannabinoids suppressed allodynia and spontaneous attacks in rats with the central pain syndrome. The analgesic effect was most pronounced after intrathecal injection of cannabinoid receptor agonist in a dose of 100 microg in 10 microl. After systemic treatment the analgesic effect was produced by only WIN 55,212-2 in a dose of 1 mg/kg. WIN 55,212-2 was superior to anandamide by the duration and intensity of the effect on allodynia and spontaneous attacks.
Kukushkin
M L
ML
Laboratory of Pathophysiology, Institute of Pathology and Pathophysiology, Russian Academy of Medical Sciences. mkukushkin@mtu-net.ru
Igon'kina
S I
SI
Churyukanov
M V
MV
Churyukanov
V V
VV
Bobrov
M Yu
MY
Bezuglov
V V
VV
Gretskaya
N V
NV
D000704:Analysis of Variance; D000818:Animals; D001095:Arachidonic Acids / Q000378:metabolism* / Q000627:therapeutic use; D048588:Benzoxazines; D063386:Cannabinoid Receptor Agonists; D004305:Dose-Response Relationship, Drug; D063388:Endocannabinoids; D007278:Injections, Spinal; D008297:Male; D009025:Morpholines / Q000378:metabolism* / Q000627:therapeutic use; D009281:Naphthalenes / Q000378:metabolism* / Q000627:therapeutic use; D010146:Pain / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism*; D010147:Pain Measurement; D010404:Penicillin V / Q000008:administration & dosage / Q000633:toxicity; D053284:Polyunsaturated Alkamides / Q000378:metabolism* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar
D001095:Arachidonic Acids; D048588:Benzoxazines; D063386:Cannabinoid Receptor Agonists; D063388:Endocannabinoids; D009025:Morpholines; D009281:Naphthalenes; D053284:Polyunsaturated Alkamides; C070417:(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone; C078814:anandamide; D010404:Penicillin V