title: In vitro activities of miltefosine and two novel antifungal biscationic salts against a panel of 77 dermatophytes.
abstract: The susceptibilities of 77 dermatophytes to miltefosine (MI), 1,12-bis(4-pentylpyridinium)dodecane (PYR), 1,12-bis(tributylammonium)dodecane (AM), itraconazole (ITC), terbinafine (TRB), and butenafine (BTF) were compared. Geometric mean MICs of TRB, BTF, ITC, MI, PYR, and AM were 0.039, 0.059, 1.718, 0.671, 6.006, and 4.771 microg/ml, respectively. MI was more active than ITC (P < 0.001).
authors: Centre for Infectious Diseases and Microbiology Laboratory, Westmead Hospital, Westmead, New South Wales 2145, Australia.
authors: Zhongsheng
authors: Z
authors: Tong
authors: Fred
authors: F
authors: Widmer
authors: Tania C
authors: TC
authors: Sorrell
authors: Zofia
authors: Z
authors: Guse
authors: Katrina A
authors: KA
authors: Jolliffe
authors: Catriona
authors: C
authors: Halliday
authors: Ok Cha
authors: OC
authors: Lee
authors: Fanrong
authors: F
authors: Kong
authors: Lesley C
authors: LC
authors: Wright
authors: Sharon C A
authors: SC
authors: Chen
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D003883:Arthrodermataceae / Q000145:classification / Q000187:drug effects*; D002412:Cations / Q000737:chemistry / Q000494:pharmacology; D002712:Chlorides / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D010767:Phosphorylcholine / Q000031:analogs & derivatives* / Q000494:pharmacology; D011726:Pyridinium Compounds / Q000737:chemistry / Q000494:pharmacology*; D000644:Quaternary Ammonium Compounds / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000935:Antifungal Agents; D002412:Cations; D002712:Chlorides; D011726:Pyridinium Compounds; D000644:Quaternary Ammonium Compounds; D010767:Phosphorylcholine; C039128:miltefosine