Antiparkinsonian activity of L-propyl-L-leucyl-glycinamide or melanocyte-inhibiting factor in MPTP-treated common marmosets.
The neuropeptide melanocyte-inhibiting factor (MIF) or L-propyl-L-leucyl-glycinamide (PLG) has been reported in some studies to improve the motor signs of Parkinson's disease (PD) and in rodent models of PD. In this study of oral and intravenous MIF in N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned marmosets, a wide range of doses of MIF administered alone (0.25, 1, 2, 5, 10, 20 mg/kg orally) did not increase locomotor activity, relieve motor disability, or induce dyskinesias. When MIF (1.0 and 5.0 mg/kg orally or 10 and 20 mg/kg intravenously) was administered concomitantly with levodopa/benserazide, no significant differences in motor function or dyskinesias were observed compared with levodopa/benserazide alone. The results of this first study of MIF in the marmoset MPTP model provide no encouragement for the reinvestigation of MIF in the clinical management of the motor signs of PD.
Katzenschlager
Regina
R
Reta Lila Weston Institute of Neurological Studies, University College London, UK.
Jackson
Michael J
MJ
Rose
Sarah
S
Stockwell
Kim
K
Tayarani-Binazir
Kayhan A
KA
Zubair
Mohammed
M
Smith
Lance A
LA
Jenner
Peter
P
Lees
Andrew J
AJ
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D000284:Administration, Oral; D000818:Animals; D000978:Antiparkinson Agents / Q000008:administration & dosage* / Q000633:toxicity; D001545:Benserazide / Q000008:administration & dosage / Q000633:toxicity; D002144:Callithrix; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D005260:Female; D007262:Infusions, Intravenous; D007980:Levodopa / Q000008:administration & dosage / Q000633:toxicity; D008124:Locomotion / Q000187:drug effects; D009075:MSH Release-Inhibiting Hormone / Q000008:administration & dosage* / Q000633:toxicity; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D020734:Parkinsonian Disorders / Q000188:drug therapy*
D000978:Antiparkinson Agents; D007980:Levodopa; D001545:Benserazide; D009075:MSH Release-Inhibiting Hormone; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine