Na+-glucose cotransporter (SGLT) inhibitory flavonoids from the roots of Sophora flavescens.
The methanol extract of Sophora flavescens, which is used in traditional Chinese medicine (sophorae radix), showed potent Na(+)-glucose cotransporter (SGLT) inhibitory activity. Our search for active components identified many well-known flavonoid antioxidants: kurarinone, sophoraflavanone G, kushenol K, and kushenol N.
Sato
Seizo
S
Central Research Laboratory, Nippon Suisan Kaisha, Ltd, 559-6 Kitano-machi, Hachioji, Tokyo 192-0906, Japan. s-satou@nissui.co.jp
Takeo
Jiro
J
Aoyama
Chihiro
C
Kawahara
Hiroyuki
H
D000818:Animals; D019556:COS Cells; D002522:Chlorocebus aethiops; D005419:Flavonoids / Q000302:isolation & purification* / Q000494:pharmacology*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D018517:Plant Roots / Q000737:chemistry; D010957:Plasmids / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction; D051269:Sodium-Glucose Transporter 1 / Q000037:antagonists & inhibitors* / Q000235:genetics; D051297:Sodium-Glucose Transporter 2 / Q000235:genetics; D000077203:Sodium-Glucose Transporter 2 Inhibitors; D029909:Sophora / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization
D005419:Flavonoids; C495674:SLC5A1 protein, human; C089180:SLC5A2 protein, human; D051269:Sodium-Glucose Transporter 1; D051297:Sodium-Glucose Transporter 2; D000077203:Sodium-Glucose Transporter 2 Inhibitors