Peroxisome proliferator-activated receptors ligands and ischemia-reperfusion injury.
Peroxisome proliferator-activated receptors (PPARs) belong to a subfamily of transcription nuclear factors. Three isoforms of PPARs have been identified: alpha, beta/delta and gamma, encoded by different genes and distributed in various tissues. They play important roles in metabolic processes like regulation of glucose and lipid redistribution. They also have anti-atherogenic, anti-inflammatory as well as antihypertensive functions. There is good evidence that ligands of PPARs reduce tissue injury associated with ischemia and reperfusion. The potential utility of PPAR ligands in ischemia and reperfusion will be discussed in this review.
Di Paola
Rosanna
R
Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Torre Biologica-Policlinico Universitario, Via C. Valeria-Gazzi, 98100 Messina, Italy.
Cuzzocrea
Salvatore
S
D000818:Animals; D001927:Brain Diseases / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D007674:Kidney Diseases / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology; D008024:Ligands; D008107:Liver Diseases / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology; D008171:Lung Diseases / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology; D008954:Models, Biological; D047492:Peroxisome Proliferator-Activated Receptors / Q000819:agonists / Q000378:metabolism / Q000502:physiology*; D015427:Reperfusion Injury / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology*
D008024:Ligands; D047492:Peroxisome Proliferator-Activated Receptors