Endobronchitis by Scedosporium apiospermum in a child with cystic fibrosis.
A case of endobronchitis by Scedosporium apiospermum in a child with cystic fibrosis is presented. The bronchial aspirate's cytology showed the presence of a large amount of septated-dichotomized hyphae. The bronchial aspirate's culture showed the presence of Scedosporium apiospermum in a pure culture of three consecutive samples. The scanning electron microscopy study of the mucosal surface revealed scarce mycelia with the presence of abundant conidiae. The transmission electron microscopy of the mucosa revealed inflammatory infiltrates constituted by macrophages, polymorphonuclear leukocytes, a lot of dichotomized mycelia and macrophages with hyphae and conidiae within the phagosomes. The patient was treated with amphotericin B and itraconazole.
Vázquez-Tsuji
Oscar
O
Laboratorio de Biología Molecular y Microscopía Electrónica, Facultad Mexicana de Medicina, Universidad La Salle, Mexico. ovztsuji@yahoo.com.mx
Campos Rivera
Teresita
T
Rondán Zárate
Adrián
A
Mirabal García
Mónica
M
D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use*; D001980:Bronchi / Q000382:microbiology; D001991:Bronchitis / Q000188:drug therapy / Q000209:etiology / Q000382:microbiology*; D002648:Child; D003550:Cystic Fibrosis / Q000150:complications*; D004198:Disease Susceptibility; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use; D008854:Microscopy, Electron; D008271:Mycetoma / Q000188:drug therapy / Q000209:etiology / Q000382:microbiology*; D020545:Respiratory Mucosa / Q000382:microbiology; D021681:Scedosporium / Q000254:growth & development / Q000302:isolation & purification* / Q000648:ultrastructure
D000935:Antifungal Agents; D017964:Itraconazole; D000666:Amphotericin B