Eosinophilic esophagitis is a component of the anticonvulsant hypersensitivity syndrome: description of two cases.
Anticonvulsant hypersensitivity syndrome is a rare syndrome caused by a specific, severe unusual reaction to antiepileptic agents; anticonvulsant hypersensitivity syndrome develops 1 week to 3 months after the introduction of the drug and most frequently consists of a multisystemic and multiorgan involvement. Drug withdrawal usually leads to rapid improvement of symptoms. Up to now no oesophageal damage has been described. We present two cases of carbamazepine hypersensitivity syndrome with concomitant development of eosinophilic oesophagitis that resolved after drug withdrawal.
Balatsinou
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C
Department of Medicine and Aging Sciences, Section of Internal Medicine and Gastroenterology and Ce.S.I. Foundation, G. D'Annunzio University & Foundation Via dei Vestini, Chieti 66100 Italy.
Milano
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A
Caldarella
M P
MP
Laterza
F
F
Pierdomenico
S D
SD
Cuccurullo
F
F
Neri
M
M
D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects*; D002220:Carbamazepine / Q000009:adverse effects*; D004342:Drug Hypersensitivity / Q000175:diagnosis* / Q000209:etiology*; D004802:Eosinophilia / Q000139:chemically induced* / Q000175:diagnosis; D004941:Esophagitis / Q000139:chemically induced* / Q000175:diagnosis; D004945:Esophagoscopy; D005260:Female; D005334:Fever / Q000139:chemically induced*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012882:Skin Tests; D013577:Syndrome
D000927:Anticonvulsants; D002220:Carbamazepine