title: Association of HLA-DRB1*16 with chronic discoid lupus erythematosus in Mexican mestizo patients.
abstract: BACKGROUND
  Chronic discoid lupus erythematosus (CDLE) is present in 15-30% of patients with systemic lupus erythematosus (SLE). Approximately 5% of CDLE cases can evolve to SLE at some stage of the disease.
  
  
  OBJECTIVE
  The aim of this study was to determine gene frequencies of HLA-DRB1 alleles in Mexican mestizo patients with CDLE, irrespective of the presence of systemic disease.
  
  
  METHODS
  The study comprised 28 Mexican mestizo patients with CDLE who were attending the Passover Dermatology Centre, in Mexico City. HLA-DRB1 and DQ allele typing was performed by sequence-specific oligotyping after DNA amplification using PCR. The study also included 99 ethnically matched healthy individuals as controls.
  
  
  RESULTS
  In the patient group, a significantly increased gene frequency was found for the HLA-DR4 (P = 0.016, OR = 2.24, 95% CI 1.14-4.38) and HLA-DR16 alleles (P = 0.005, OR = 5.51, 95% CI 1.49-21.08).
  
  
  CONCLUSIONS
  HLA-DRB1 alleles seem to be involved in the genetic susceptibility to CDLE in the Mexican mestizo population.
authors: Passover Dermatology Centre, Mexico City, Mexico.
authors: A
authors: A
authors: López-Tello
authors: A A
authors: AA
authors: Rodríguez-Carreón
authors: F
authors: F
authors: Jurado
authors: J K
authors: JK
authors: Yamamoto-Furusho
authors: M
authors: M
authors: Castillo-Vázquez
authors: C
authors: C
authors: Chávez-Muñoz
authors: N
authors: N
authors: Salgado
authors: O
authors: O
authors: Arellano-Campos
authors: G
authors: G
authors: Vargas-Alarcón
authors: J
authors: J
authors: Granados
mesh_terms: D000293:Adolescent; D000328:Adult; D000483:Alleles; D002648:Child; D002908:Chronic Disease; D005260:Female; D005787:Gene Frequency; D005802:Genes, MHC Class II; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006684:HLA-DR Antigens / Q000235:genetics*; D059810:HLA-DR Serological Subtypes; D059811:HLA-DRB1 Chains; D006801:Humans; D008179:Lupus Erythematosus, Discoid / Q000235:genetics*; D008297:Male; D008800:Mexico / Q000208:ethnology; D008875:Middle Aged
chemical_list: D006684:HLA-DR Antigens; D059810:HLA-DR Serological Subtypes; C067266:HLA-DR16 antigen; D059811:HLA-DRB1 Chains