Confirmation of region-specific patterns of gene expression in the human brain.
The human brain is divided and categorized in different ways, yet a molecular genetic approach to region specificity does not exist. Using data from 12 healthy control subjects across 18 brain regions, we performed a microarray analysis using both the HG-U133AB and HG-U133 plus 2 chips for each subject to determine molecular targets showing region specificity. Using a previously published data as our guide, we confirm SIX3, GPR6, SH3RF2, and hSyn as molecular markers of the nucleus accumbens and gamma-aminobutyric-acid A receptor alpha-6, Nik-related kinase, and eomesodermin as molecular markers of the cerebellum.
Ernst
Carl
C
McGill Group for Suicide Studies, McGill University, Montreal, QC, Canada.
Sequeira
Adolfo
A
Klempan
Tim
T
Ernst
Neil
N
Ffrench-Mullen
Jarlath
J
Turecki
Gustavo
G
D001921:Brain / Q000033:anatomy & histology / Q000502:physiology*; D002531:Cerebellum / Q000502:physiology; D004247:DNA / Q000235:genetics*; D015870:Gene Expression; D005819:Genetic Markers; D006801:Humans; D009419:Nerve Tissue Proteins / Q000235:genetics*; D020411:Oligonucleotide Array Sequence Analysis; D011963:Receptors, GABA-A / Q000235:genetics
D005819:Genetic Markers; D009419:Nerve Tissue Proteins; D011963:Receptors, GABA-A; D004247:DNA