Study of the effects on DNA of two novel nucleoside derivatives synthesized as potential anti-HIV agents.
The pursuit of antiviral active compounds against different classes of viruses, in particular HIV, HBV, and HTLV is an area of important and intense research. In the current study, two novel nucleoside derivatives belonging to a new class of isoxazolidine were successfully synthesized as potential anti-HIV agents by replacement of the furanose ring by a N,O-heterocyclic ring Both compounds were investigated for biological activity, namely, mutagenic and antimutagenic properties. Using Salmonella typhimurium strains TA97, TA100, and TA102, both compounds proved to be nonmutagenic, which may be considered an encouraging result to further elucidate other biological activities. Antimutagenic testing of the synthesized compounds revealed that they are active against the base-pair substitution mutagen sodium azide. However, they did not show any indication as antimutagenic agents against hydrogen peroxide and mitomycin C (oxidative mutagens) or against nitrophenylenediamine (a base-pair substitution and frameshift mutagen). Structure-activity relationship is also discussed. Testing these compounds as antiviral agents is highly recommended.
Maslat
Ahmed O
AO
Department of Biological Sciences, Yarmouk University, Irbid, Jordan. mass7000@yahoo.com
Bkhaitan
Majdi
M
Sheikha
Ghassan Abu
GA
D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D004247:DNA / Q000378:metabolism*; D007555:Isoxazoles / Q000138:chemical synthesis* / Q000737:chemistry; D009152:Mutagenicity Tests; D009705:Nucleosides / Q000737:chemistry*; D012486:Salmonella typhimurium / Q000187:drug effects* / Q000235:genetics; D019810:Sodium Azide / Q000378:metabolism; D013329:Structure-Activity Relationship
D019380:Anti-HIV Agents; D007555:Isoxazoles; D009705:Nucleosides; D004247:DNA; D019810:Sodium Azide