Recent studies on selected botanical dietary supplement ingredients.
The market for botanical dietary supplements in the US has grown rapidly during the last 15 years. Use of newly introduced botanical ingredients has often outpaced an adequate scientific understanding of the ingredients themselves. This may lead to problems, including misidentification, mislabeling, adulteration, and toxicity related to the intended ingredient or one substituted for it. This article reviews recent work with several botanical ingredients (Ephedra, Citrus species, Hoodia gordonii, Teucrium, isoflavones) that illustrates the complexity of the current situation and approaches that contribute to ensuring the quality of botanical ingredients. Recent work with contamination of botanical products by mycotoxins is also reviewed. The need for tools for botanical authentication and methods for reproducible extraction of bioactive constituents is critical. Such tools, and improved analytical techniques for identifying potentially bioactive constituents in fresh plant material and in concentrated extracts and for detection of hazardous contaminants, are expected to improve the overall quality and safety of botanical dietary supplement ingredients.
Rader
Jeanne I
JI
Division of Bioanalytical Chemistry, Office of Regulatory Science, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740, USA. Jeanne.Rader@fda.hhs.gov
Delmonte
Pierluigi
P
Trucksess
Mary W
MW
D019587:Dietary Supplements / Q000032:analysis* / Q000592:standards; D007529:Isoflavones / Q000032:analysis / Q000737:chemistry; D009183:Mycotoxins / Q000032:analysis / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry*
D007529:Isoflavones; D009183:Mycotoxins; D010936:Plant Extracts