Functional characterization of human thyroid tissue with immunohistochemistry.
Immunohistochemistry provides insights in the expression of functional proteins and of their localization in normal thyroid tissue and in thyroid diseases. In hyperfunctional thyroid tissues, staining for sodium/iodide symporter (NIS), pendrin, thyroid peroxidase (TPO), and thyroglobulin (Tg) is increased. In hypofunctioning thyroid tissues, NIS staining is markedly decreased; in benign hypofunctioning adenomas, the expression of the other functional proteins is unmodified or slightly decreased, whereas their expression is profoundly decreased or absent in differentiated thyroid carcinoma.
Faggiano
Antongiulio
A
Department of Pathology, Commissariat à l'Energie Atomique LRC29V, Institut Gustave Roussy, University Paris Sud, Villejuif Cedex, France.
Caillou
Bernard
B
Lacroix
Ludovic
L
Talbot
Monique
M
Filetti
Sebastiano
S
Bidart
Jean-Michel
JM
Schlumberger
Martin
M
D015415:Biomarkers / Q000737:chemistry; D002277:Carcinoma / Q000378:metabolism; D000939:Epitopes / Q000737:chemistry; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods*; D007453:Iodide Peroxidase / Q000378:metabolism*; D026901:Membrane Transport Proteins / Q000378:metabolism*; D009362:Neoplasm Metastasis; D011379:Prognosis; D000076988:Sulfate Transporters; D027981:Symporters / Q000378:metabolism*; D013954:Thyroglobulin / Q000378:metabolism*; D013961:Thyroid Gland / Q000473:pathology*; D013964:Thyroid Neoplasms / Q000378:metabolism; D000099209:Sodium-Iodide Symporters
D015415:Biomarkers; D000939:Epitopes; D007453:Iodide Peroxidase; D026901:Membrane Transport Proteins; D000076988:Sulfate Transporters; D027981:Symporters; D013954:Thyroglobulin; D000099209:Sodium-Iodide Symporters; C085609:SLC26A4 protein, human