title: In vivo retinal tolerance of various heavy silicone oils.
abstract: OBJECTIVE
  Heavy silicone oils are currently under investigation as a permanent tamponade in eyes with inferior PVR. This study was an investigation of Densiron 68 (Fluoron GmbH, Neu-Ulm, Germany) and several new heavy silicone oil admixtures on the basis of the perfluoroalkanes F4H5 (perfluorobutylpentane), F4H6 (perfluorobutylhexane), and F4H8 (perfluorobutyloctane) with respect to their long-term tolerance in a rabbit model.
  
  
  METHODS
  Because of the better solubility of the F4Hn-species (n = 5-8) in comparison to F6H8, we used F4H5, F4H6, and F4H8 to generate highly viscous, heavy silicone oils (HSO). After vitrectomy and fluid-air exchange, the left eye of each of five rabbits per group was filled with HSO 68-1500 (Densiron 68), HSO 45-5000, HSO 45-3000, HSO 46-5000, HSO 46-3000, HSO 48-5000, or HSO 48-3000, or pure F4H5, F4H6, or F4H8. Detailed clinical investigation, ERG testing, and histologic evaluation were performed throughout a 3-month follow-up.
  
  
  RESULTS
  Densiron 68 and HSOs based on F4H5, as well as the three control oils (silicone oil of 1000, 3000, and 5000 mPa . s) were well tolerated over 3 months. Histologically, the retina was unaffected. In contrast, intraocular inflammation, cataract formation, and retinal detachment and degeneration were noticed in all groups with HSOs based on F4H6 or F4H8.
  
  
  CONCLUSIONS
  Biocompatibility of the new HSOs is dependent on the lipophilic behavior (R(F)/R(H) ratio) and furthermore on the molecular dimension of the used semifluorinated alkanes (SFAs). HSOs on the basis of F4H5 may have advantages over silicone oils, on the basis of F6H8, for use as a tamponade agent for the inferior retina in difficult retinal situations.
authors: Department of Vitreoretinal Surgery, Center for Ophthalmology, University of Cologne, Cologne, Germany.
authors: Jerzy
authors: J
authors: Mackiewicz
authors: Bastian
authors: B
authors: Mühling
authors: Wilfried
authors: W
authors: Hiebl
authors: Hasso
authors: H
authors: Meinert
authors: Kristel
authors: K
authors: Maaijwee
authors: Norbert
authors: N
authors: Kociok
authors: Christoph
authors: C
authors: Lüke
authors: Zbigniew
authors: Z
authors: Zagorski
authors: Bernd
authors: B
authors: Kirchhof
authors: Antonia M
authors: AM
authors: Joussen
mesh_terms: D000818:Animals; D004596:Electroretinography; D008422:Materials Testing; D011817:Rabbits; D012160:Retina / Q000187:drug effects* / Q000503:physiopathology; D012164:Retinal Diseases / Q000139:chemically induced* / Q000473:pathology; D012827:Silicone Oils / Q000737:chemistry / Q000633:toxicity*; D014783:Viscosity; D014821:Vitrectomy; D014822:Vitreous Body / Q000187:drug effects
chemical_list: D012827:Silicone Oils