How does an mRNA find its way? Intracellular localisation of transcripts.
The localisation of transcripts to specific regions of the cell probably occurs in all cell types and has many distinct functions that go from the control of body axis formation to learning and memory. mRNAs can be localised by a variety of mechanisms including local protection from degradation, diffusion to a localised anchor, and active transport by motor proteins along the cytoskeleton. In this review, I consider the evidence for each of these mechanisms using a limited, but illustrative, number of examples of localised mRNAs.
Palacios
Isabel M
IM
Department of Zoology, University of Cambridge, Downing Street CB2 3EJ, United Kingdom. mip22@hermes.cam.ac.uk
D000818:Animals; D006801:Humans; D008954:Models, Biological; D012333:RNA, Messenger / Q000235:genetics* / Q000378:metabolism*; D014158:Transcription, Genetic
D012333:RNA, Messenger