Association of HLA-DRB1*16 with chronic discoid lupus erythematosus in Mexican mestizo patients.
BACKGROUND
Chronic discoid lupus erythematosus (CDLE) is present in 15-30% of patients with systemic lupus erythematosus (SLE). Approximately 5% of CDLE cases can evolve to SLE at some stage of the disease.


OBJECTIVE
The aim of this study was to determine gene frequencies of HLA-DRB1 alleles in Mexican mestizo patients with CDLE, irrespective of the presence of systemic disease.


METHODS
The study comprised 28 Mexican mestizo patients with CDLE who were attending the Passover Dermatology Centre, in Mexico City. HLA-DRB1 and DQ allele typing was performed by sequence-specific oligotyping after DNA amplification using PCR. The study also included 99 ethnically matched healthy individuals as controls.


RESULTS
In the patient group, a significantly increased gene frequency was found for the HLA-DR4 (P = 0.016, OR = 2.24, 95% CI 1.14-4.38) and HLA-DR16 alleles (P = 0.005, OR = 5.51, 95% CI 1.49-21.08).


CONCLUSIONS
HLA-DRB1 alleles seem to be involved in the genetic susceptibility to CDLE in the Mexican mestizo population.
López-Tello
A
A
Passover Dermatology Centre, Mexico City, Mexico.
Rodríguez-Carreón
A A
AA
Jurado
F
F
Yamamoto-Furusho
J K
JK
Castillo-Vázquez
M
M
Chávez-Muñoz
C
C
Salgado
N
N
Arellano-Campos
O
O
Vargas-Alarcón
G
G
Granados
J
J
D000293:Adolescent; D000328:Adult; D000483:Alleles; D002648:Child; D002908:Chronic Disease; D005260:Female; D005787:Gene Frequency; D005802:Genes, MHC Class II; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006684:HLA-DR Antigens / Q000235:genetics*; D059810:HLA-DR Serological Subtypes; D059811:HLA-DRB1 Chains; D006801:Humans; D008179:Lupus Erythematosus, Discoid / Q000235:genetics*; D008297:Male; D008800:Mexico / Q000208:ethnology; D008875:Middle Aged
D006684:HLA-DR Antigens; D059810:HLA-DR Serological Subtypes; C067266:HLA-DR16 antigen; D059811:HLA-DRB1 Chains