Decreased expression of insulin-like growth factor binding protein 2 in the prefrontal cortex of subjects with bipolar disorder and its regulation by lithium treatment.
Insulin-like growth factors (IGFs) regulate cellular proliferation and death, and their bioactivity is controlled by IGF binding proteins (IGFBPs). Since IGFBP-2 is the major brain resident IGFBP, and we have demonstrated lithium-mediated changes in its mRNA and protein levels in neuronal cultures, we examined IGFBP-2 expression in prefrontal cortex postmortem brain tissue from subjects with mood disorders. We found decreased IGFBP-2 expression in bipolar disorder patients compared with controls; this was especially pronounced in subjects not treated with lithium. These results suggest a role for IGFBPs in the etiology and pharmacotherapy of mood disorders.
Bezchlibnyk
Yarema B
YB
The Vivian Rakoff Mood Disorders Lab, Centre for Addiction and Mental Health, Toronto, ON, Canada.
Xu
Li
L
Wang
Jun-Feng
JF
Young
L Trevor
LT
D000328:Adult; D000704:Analysis of Variance; D001714:Bipolar Disorder / Q000188:drug therapy / Q000378:metabolism*; D016022:Case-Control Studies; D003865:Major Depressive Disorder / Q000188:drug therapy / Q000378:metabolism; D015536:Down-Regulation; D005260:Female; D006801:Humans; D018971:Insulin-Like Growth Factor Binding Protein 2 / Q000187:drug effects / Q000235:genetics / Q000378:metabolism*; D018020:Lithium Compounds / Q000627:therapeutic use*; D008297:Male; D016555:Matched-Pair Analysis; D008875:Middle Aged; D017397:Prefrontal Cortex / Q000187:drug effects / Q000378:metabolism* / Q000503:physiopathology; D012333:RNA, Messenger / Q000032:analysis; D012016:Reference Values; D018709:Statistics, Nonparametric
D018971:Insulin-Like Growth Factor Binding Protein 2; D018020:Lithium Compounds; D012333:RNA, Messenger