Fibroblast growth factor-2 promotes recovery of pulmonary function in a canine models of elastase-induced emphysema.
Bronchoscopic lung volume reduction (BLVR) for severe emphysema is less invasive than lung volume reduction surgery. Fibroblast growth factor-2 (FGF-2) has been reported to enhance fibrogenesis and angiogenesis. The aim of this study was to investigate the feasibility of BLVR with the FGF-2, and ability to reduce lung volume and promote recovery of lung function. The BLVR based on FGF-2 is less invasive than surgical procedures, and can be performed repeatedly if the effectiveness of volume reduction is inadequate. This simple bronchoscopic approach allows selective reduction in the volume of the emphysematous parenchyma, and intratracheal administration of FGF-2 induces an increase in pulmonary blood flow, thus allowing recovery of pulmonary function.
Morino
Shigeyuki
S
Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan. morinos@frontier.kyoto-u.ac.jp
Toba
Toshinari
T
Tao
Hiroyuki
H
Araki
Masato
M
Shimizu
Yasuhiko
Y
Nakamura
Tatsuo
T
Nagayasu
Takeshi
T
Tagawa
Tsutomu
T
D000280:Administration, Inhalation; D000818:Animals; D003131:Combined Modality Therapy; D004195:Disease Models, Animal; D004285:Dogs; D004646:Emphysema / Q000139:chemically induced / Q000188:drug therapy* / Q000601:surgery*; D016222:Fibroblast Growth Factor 2 / Q000494:pharmacology*; D007442:Intubation, Intratracheal; D008176:Lung Volume Measurements; D010100:Oxygen / Q000097:blood; D010196:Pancreatic Elastase; D011013:Pneumonectomy; D011652:Pulmonary Circulation / Q000187:drug effects; D020127:Recovery of Function / Q000187:drug effects*; D012129:Respiratory Function Tests
D016222:Fibroblast Growth Factor 2; D010196:Pancreatic Elastase; D010100:Oxygen