Synergistic effects of chemical enhancers on skin permeability: a case study of sodium lauroylsarcosinate and sorbitan monolaurate.
Certain mixtures of chemicals are known to synergistically enhance skin permeability to drugs. Here, we report on the transport enhancing properties of mixtures of an anionic surfactant, sodium lauroylsarcosinate (NLS) and a non-ionic surfactant, sorbitan monolaurate (S20) in 1:1 phosphate buffered saline (PBS):ethanol (EtOH) solvent. Effect of 44 different compositions of NLS:S20 on skin constituents was probed by Fourier transform-infrared (FT-IR) spectroscopy while behavior of surfactant molecules in the solvent system was probed by FT-IR and NMR spectroscopy. No aggregation of NLS or S20 alone was observed in 1:1 PBS:EtOH at all concentrations studied (0-2%, w/v). However, mixtures of NLS and S20 resulted in micelle-like aggregates at certain specific compositions. Interestingly, compositions with increased aggregation showed resemblance to those that exhibited highest skin permeabilization.
Karande
Pankaj
P
Department of Chemical Engineering, University of California, Santa Barbara, CA 93106, USA.
Jain
Amit
A
Arora
Anubhav
A
Ho
Moon Jean
MJ
Mitragotri
Samir
S
D000277:Adjuvants, Pharmaceutic / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology*; D000818:Animals; D004553:Electric Conductivity; D004817:Epidermis / Q000187:drug effects / Q000378:metabolism / Q000502:physiology; D000431:Ethanol / Q000737:chemistry; D006601:Hexoses / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D066298:In Vitro Techniques; D008051:Lipid Bilayers / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010539:Permeability / Q000187:drug effects; D012521:Sarcosine / Q000031:analogs & derivatives / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D012867:Skin / Q000187:drug effects* / Q000378:metabolism; D012869:Skin Absorption / Q000187:drug effects* / Q000502:physiology; D017550:Spectroscopy, Fourier Transform Infrared; D013552:Swine
D000277:Adjuvants, Pharmaceutic; D006601:Hexoses; D008051:Lipid Bilayers; D000431:Ethanol; C025231:sarkosyl; C014822:sorbitan monolaurate; D012521:Sarcosine