[Relationship between lipid peroxidation in blood and neurobehavioral function changes in coke oven workers].
OBJECTIVE
To explore the coincidence of lipid peroxidation and neurobehavioral function changes in coke oven workers.


METHODS
One hundred and thirty-four coke oven workers were divided into three groups: 35 in the oven-bottom group, 49 in the oven-side group and 50 in oven-top group. WHO recommended NCTB was performed on coke oven workers and 36 controls from material conservation department; The contents of total superoxide dismutases (T-SOD), glutathione (GSH) and malondialdehyde (MDA) in blood were determined by test kits.


RESULTS
Compared with the controls, the coke oven workers showed lower levels of T-SOD and GSH (P < 0.01), significantly higher MDA levels in blood (P < 0.01), higher score on negative mood state, lower scores on positive mood state, and poorer performance in NCTB test (P < 0.05). Further analysis revealed that there was a weak positive correlation between neurobehavioral function changes and the level of lipid peroxidation with a coefficient lower than 0.25.


CONCLUSIONS
The level of lipid peroxidation in coke oven workers' blood increased and coincided with neurobehavioral function impairment.
Wang
Fang
F
Department of Occupational Health, School of Public Health, Shanxi Medical University, Taiyuan, China.
Zhang
Hong-Mei
HM
Nie
Ji-Sheng
JS
Xue
Cui-E
CE
Shi
Ying-Tao
YT
Niu
Qiao
Q
D000328:Adult; D000339:Affect; D001007:Anxiety; D016022:Case-Control Studies; D003077:Coke; D005221:Fatigue; D005978:Glutathione / Q000097:blood; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D016273:Occupational Exposure / Q000009:adverse effects*; D013482:Superoxide Dismutase / Q000097:blood; D055815:Young Adult
D003077:Coke; D008315:Malondialdehyde; D013482:Superoxide Dismutase; D005978:Glutathione