title: An intervention to improve secondary prevention of coronary heart disease.
abstract: BACKGROUND
  Translating guidelines into clinical practice has proved to be quite difficult, even when the guidelines are well accepted and noncontroversial. Both computerized reminders and academic detailing have been effective in changing physician prescribing behavior. In this study, we sought to use these methods, mediated by clinical pharmacists, to improve adherence to the secondary prevention guidelines in hospitalized patients with myocardial infarction.
  
  
  METHODS
  A randomized, prospective study was performed in which computerized alerts identifying hospitalized patients with elevated troponin I levels were routed to clinical pharmacists. The pharmacists then conducted academic detailing for physicians caring for patients with acute myocardial infarction who were randomized to the intervention group. Patients in the control group received standard care. The main outcome measure was the proportion of patients discharged on a regimen of aspirin, beta-blockers, angiotensin-converting enzyme inhibitors, and statins.
  
  
  RESULTS
  The intervention had a significant impact on the proportion of patients discharged on a regimen of angiotensin-converting enzyme inhibitors (328/365 [89.9%] vs 409/488 [83.8%], intervention vs control, respectively, P = .02), and statins (344/365 [94.2%] vs 436/488 [89.3%], P = .02). There was no statistical impact on beta-blocker (350/365 [95.9%] vs 448/488 [91.8%], P = .10) or aspirin use (352/365 [96.4%] vs 471/488 [96.5%], P = .87). When all 4 classes were considered together, 305 (83.6%) of 365 patients vs 343 (70.3%) of 488 patients were discharged on a regimen of all secondary prevention medications to which they did not have a contraindication (P<.001).
  
  
  CONCLUSIONS
  A computerized alert with pharmacist-mediated academic detailing is an effective means to increase adherence to secondary prevention guidelines for coronary heart disease.
authors: Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA. tbailey@im.wustl.edu
authors: Thomas C
authors: TC
authors: Bailey
authors: Laura A
authors: LA
authors: Noirot
authors: Amy
authors: A
authors: Blickensderfer
authors: Erin
authors: E
authors: Rachmiel
authors: Robyn
authors: R
authors: Schaiff
authors: Anthony
authors: A
authors: Kessels
authors: Alan
authors: A
authors: Braverman
authors: Anne
authors: A
authors: Goldberg
authors: Brian
authors: B
authors: Waterman
authors: W Claiborne
authors: WC
authors: Dunagan
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000368:Aged; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D001241:Aspirin / Q000627:therapeutic use; D016303:Clinical Pharmacy Information Systems; D004363:Drug Utilization / Q000706:statistics & numerical data; D005260:Female; D019983:Guideline Adherence; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D008923:Missouri; D009203:Myocardial Infarction / Q000097:blood / Q000517:prevention & control*; D010351:Patient Discharge; D010595:Pharmacists; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D017410:Practice Guidelines as Topic; D011446:Prospective Studies; D055502:Secondary Prevention; D019210:Troponin I / Q000097:blood
chemical_list: D000319:Adrenergic beta-Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D010975:Platelet Aggregation Inhibitors; D019210:Troponin I; D001241:Aspirin