Spectrum of FGFR3 mutations in multiple intraindividual seborrheic keratoses.
Somatic FGFR3 mutations have recently been identified in seborrheic keratoses (SK). Affected individuals often show a large number of SK, but their spectrum of FGFR3 mutations has not been investigated yet. We analyzed 78 SK of four patients using a SNaPshot multiplex assay. FGFR3 mutations were detected in 46 of 78 SK (59%). The mutation rates of the patients ranged from 26 to 89%. Each patient showed at least four different mutated loci. FGFR3 mutations appear to be common genetic alterations in multiple SK with a varying interindividual mutation frequency but without specific intraindividual hot spots.
Hafner
Christian
C
Department of Dermatology, University of Regensburg, Regensburg, Germany. christian.hafner@klinik.uni-regensburg.de
Hartmann
Arndt
A
Real
Francisco X
FX
Hofstaedter
Ferdinand
F
Landthaler
Michael
M
Vogt
Thomas
T
D006801:Humans; D017492:Keratosis, Seborrheic / Q000235:genetics*; D009154:Mutation; D051498:Receptor, Fibroblast Growth Factor, Type 3 / Q000378:metabolism*
D051498:Receptor, Fibroblast Growth Factor, Type 3