Inflammation in prostate carcinogenesis.
About 20% of all human cancers are caused by chronic infection or chronic inflammatory states. Recently, a new hypothesis has been proposed for prostate carcinogenesis. It proposes that exposure to environmental factors such as infectious agents and dietary carcinogens, and hormonal imbalances lead to injury of the prostate and to the development of chronic inflammation and regenerative 'risk factor' lesions, referred to as proliferative inflammatory atrophy (PIA). By developing new experimental animal models coupled with classical epidemiological studies, genetic epidemiological studies and molecular pathological approaches, we should be able to determine whether prostate cancer is driven by inflammation, and if so, to develop new strategies to prevent the disease.
De Marzo
Angelo M
AM
Johns Hopkins University School of Medicine, Department of Pathology, Baltimore, MD, USA. ademarz@jhmi.edu
Platz
Elizabeth A
EA
Sutcliffe
Siobhan
S
Xu
Jianfeng
J
Grönberg
Henrik
H
Drake
Charles G
CG
Nakai
Yasutomo
Y
Isaacs
William B
WB
Nelson
William G
WG
D002273:Carcinogens; D002869:Chromosome Aberrations; D002908:Chronic Disease; D004032:Diet; D044127:Epigenesis, Genetic; D006801:Humans; D007239:Infections / Q000150:complications; D007249:Inflammation / Q000150:complications* / Q000235:genetics; D008297:Male; D008954:Models, Biological; D009154:Mutation; D011471:Prostatic Neoplasms / Q000209:etiology* / Q000235:genetics; D011472:Prostatitis / Q000150:complications* / Q000209:etiology; D012307:Risk Factors
D002273:Carcinogens