Responses of normal cells to ionizing radiation.
Radiation-induced alterations in cellular tissue homeostasis triggered by various molecular responses at the level of inter- and intracellular signaling processes cause both acute and late effects in normal tissue after radiation therapy. Some of the underlying molecular and cellular response pathways leading to radiation-induced tissue remodeling will be discussed, with special emphasis on vascular and parenchymal tissues.
Rodemann
H Peter
HP
Department of Radiation Oncology, Division of Radiobiology and Molecular Environmental Research, Eberhard-Karls University, Tübingen, Germany. hans-peter.rodemann@uni-tuebingen.de
Blaese
Marcel A
MA
D017209:Apoptosis / Q000528:radiation effects; D002455:Cell Division / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D006706:Homeostasis; D006801:Humans; D011832:Radiation Injuries / Q000473:pathology*; D011836:Radiation Tolerance; D011839:Radiation, Ionizing; D011878:Radiotherapy / Q000009:adverse effects*; D015398:Signal Transduction / Q000528:radiation effects