Intrapartum maternal glucose infusion and fetal acid-base status.
OBJECTIVE
To compare the effects of an intrapartum infusion of a lactated Ringer solution or a glucose-boosted saline solution on the acid-base status of umbilical arterial blood.


METHODS
In a prospective clinical trial 178 women in labor were randomized to receive intravenously either a lactated Ringer solution or a saline solution boosted with 5% glucose. Umbilical arterial blood was then assessed for acid-base status.


RESULTS
There were significant differences between the lactated Ringer group and the glucose group in umbilical artery pH values (7.25+/-0.07 vs. 7.28+/-0.06; P=0.008), pCO2 values (44.8+/-5.6 mm Hg vs. 41.6+/-4.1 mm Hg; P=0.001), and base excess (-7.3+/-2.1 mEq/L vs. -6.6+/-1.8 mEq/L; P=0.02).


CONCLUSIONS
Intrapartum intravenous fluid containing a 5% glucose solution reduces umbilical cord acidemia and hypercarbia.
Jamal
A
A
Perinatology Division, Department of Obstetrics and Gynecology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran. jamalsh@sina.tums.ac.ir
Choobak
N
N
Tabassomi
F
F
D000136:Acid-Base Equilibrium / Q000187:drug effects*; D000328:Adult; D001786:Blood Glucose; D002585:Cesarean Section; D005215:Fasting; D005260:Female; D005333:Fetus / Q000187:drug effects* / Q000473:pathology*; D005947:Glucose / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D007262:Infusions, Intravenous; D007552:Isotonic Solutions / Q000008:administration & dosage* / Q000009:adverse effects; D007743:Labor, Obstetric / Q000502:physiology; D011247:Pregnancy; D011446:Prospective Studies; D000077325:Ringer's Lactate; D014469:Umbilical Arteries
D001786:Blood Glucose; D007552:Isotonic Solutions; D000077325:Ringer's Lactate; D005947:Glucose