Serum and urine levels of interleukin-6 and interleukin-8 in children with acute pyelonephritis.
Urinary tract infection (UTI) is a common clinical disorder in younger infants and children and may result in permanent renal damage. The inflammatory cytokines interleukin (IL)-6 and IL-8 play an important role in response to bacterial infection. This prospective study investigated the association between serum and urine IL-6 and IL-8 levels and acute pyelonephritis confirmed by (99m)Tc-dimercaptosuccinic acid (DMSA) scan. A total of 78 children aged 1-121 months with a diagnosis of first-time febrile UTI were included. The following inflammatory markers were assessed: fever; white blood cells count (WBC); C-reactive protein (CRP); and serum and urine IL-6 and IL-8. The patients were divided into the acute pyelonephritis group (n=42) and the lower UTI group (n=36) according to the results of DMSA scan. Fever, WBC and CRP levels were significantly higher in children with acute pyelonephritis than in those with lower UTI (all p <0.001). Significantly, higher initial serum and urine IL-6 and IL-8 levels were found in children with acute pyelonephritis than in those with lower UTI (all p <0.001). Serum and urine IL-6 in children with acute pyelonephritis were positively correlated with fever, CRP and leucocyturia. These results indicate that both serum and urine IL-6 and IL-8 levels, particularly IL-6, are useful diagnostic tools for early recognition of acute pyelonephritis in febrile children.
Sheu
Ji-Nan
JN
Department of Pediatrics, Chung Shan Medical University Hospital, Taichung 402, Taiwan; Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan. cshy098@csh.org.tw
Chen
Meng-Chi
MC
Lue
Ko-Huang
KH
Cheng
Sun-Long
SL
Lee
Inn-Chi
IC
Chen
Shan-Ming
SM
Tsay
Gregory J
GJ
D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D015850:Interleukin-6 / Q000097:blood* / Q000652:urine*; D016209:Interleukin-8 / Q000097:blood* / Q000652:urine*; D008297:Male; D011704:Pyelonephritis / Q000097:blood / Q000175:diagnosis / Q000276:immunology* / Q000652:urine; D014718:Vesico-Ureteral Reflux / Q000097:blood / Q000175:diagnosis / Q000276:immunology / Q000652:urine
D015850:Interleukin-6; D016209:Interleukin-8