title: Affibody molecules: potential for in vivo imaging of molecular targets for cancer therapy.
abstract: Targeting radionuclide imaging of tumor-associated antigens may help to select patients who will benefit from a particular biological therapy. Affibody molecules are a novel class of small (approximately 7 kDa) phage display-selected affinity proteins, based on the B-domain scaffold of staphylococcal protein A. A large library (3 x 10(9) variants) has enabled selection of high-affinity (up to 22 pM) binders for a variety of tumor-associated antigens. The small size of Affibody molecules provides rapid tumor localization and fast clearance from nonspecific compartments. Preclinical studies have demonstrated the potential of Affibody molecules for specific and high-contrast radionuclide imaging of HER2 in vivo, and pilot clinical data using indium-111 and gallium-68 labeled anti-HER2 Affibody tracer have confirmed its utility for radionuclide imaging in cancer patients.
authors: Affibody AB, Box 20137, SE-161 02 Bromma, Swedenn. Vladimir.Tolmachev@bms.uu.se
authors: Vladimir
authors: V
authors: Tolmachev
authors: Anna
authors: A
authors: Orlova
authors: Fredrik Y
authors: FY
authors: Nilsson
authors: Joachim
authors: J
authors: Feldwisch
authors: Anders
authors: A
authors: Wennborg
authors: Lars
authors: L
authors: Abrahmsén
mesh_terms: D000951:Antigens, Neoplasm; D006801:Humans; D009369:Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000276:immunology; D011877:Radionuclide Imaging; D011993:Recombinant Fusion Proteins
chemical_list: D000951:Antigens, Neoplasm; D011993:Recombinant Fusion Proteins; C515865:Z(HER2.4)2 affibody