title: Angiopoietin 1 (Ang-1), angiopoietin 2 (Ang-2) and Tie-2 (a receptor tyrosine kinase) concentrations in peripheral blood of patients with thyroid cancers.
abstract: There are limited and conflicting studies investigating the role of the angiopoietin family in human thyroid cancer development and progression. We have investigated cytokines angiopoietin-1, -2 and their receptor (Tie-2), known to be involved in angiogenesis, in the serum of 52 thyroid cancer patients (21 cases of papillary cancers, PTC; 8 follicular cancers, FTC; 12 medullary cancers, MTC and 11 anaplastic cancers, ATC), using ELISA assays. The control consisted of 27 healthy volunteers. Statistically significant lower concentrations of Ang-1 were found in patients with thyroid cancers as compared with the control (p<0.003). The levels of Ang-2 and Tie-2 did not differ significantly between thyroid cancer patients and control. We have also compared the results of Ang-1, Ang-2, and Tie-2 determinations obtained in different histopathological subgroups of cancer patients. These results revealed lower Ang-1 concentrations in ATC (p<0.05), MTC (p<0.02), FTC (p<0.01) and in PTC patients (p<0.05) than control. We have also observed lower Ang-2 concentration in PTC patients (p<0.03) and Tie-2 in FTC patients (p<0.02 ) in comparison to controls. In conclusion, the Angs/Tie-2 system dysfunction may play an important role in thyroid cancerogenesis and decreased concentration of Ang-1 in serum can be a useful additional biomarker for the presence of thyroid cancers.
authors: Department of General and Endocrinological Surgery, Medical University of Łódź, Copernicus Hospital, Pabianicka 62, 93-513 Łódź, Poland.
authors: Sebastian
authors: S
authors: Niedźwiecki
authors: Tomasz
authors: T
authors: Stepień
authors: Krzysztof
authors: K
authors: Kopeć
authors: Krzysztof
authors: K
authors: Kuzdak
authors: Jan
authors: J
authors: Komorowski
authors: Roman
authors: R
authors: Krupiński
authors: Henryk
authors: H
authors: Stepień
mesh_terms: D000328:Adult; D000368:Aged; D042683:Angiopoietin-1 / Q000097:blood*; D042702:Angiopoietin-2 / Q000097:blood*; D014408:Biomarkers, Tumor / Q000097:blood*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D042787:Receptor, TIE-2 / Q000097:blood*; D013964:Thyroid Neoplasms / Q000097:blood / Q000175:diagnosis*
chemical_list: D042683:Angiopoietin-1; D042702:Angiopoietin-2; D014408:Biomarkers, Tumor; D042787:Receptor, TIE-2