Low plasma levels of the protein pro-LL-37 as an early indication of severe disease in patients with chronic neutropenia.
Chronic neutropenia comprises several different diseases that vary in degree of severity and management. We analysed the levels of the neutrophil-derived protein pro-LL-37 in plasma of patients with chronic neutropenia to assess whether it could be used to differentiate different categories of chronic neutropenia. All patients with severe congenital neutropenia were pro-LL-37 deficient. This was in contrast to patients with autoimmune or idiopathic neutropenia, who exhibited normal pro-LL-37 levels while patients with cyclic neutropenia displayed an oscillation of pro-LL-37 in plasma. Plasma levels of pro-LL-37 may thus prove useful for differential diagnosis of chronic neutropenia.
Karlsson
Jenny
J
Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
Carlsson
Göran
G
Ramme
Kim Göransdotter
KG
Hägglund
Hans
H
Fadeel
Bengt
B
Nordenskjöld
Magnus
M
Henter
Jan-Inge
JI
Palmblad
Jan
J
Pütsep
Katrin
K
Andersson
Mats
M
D000293:Adolescent; D000328:Adult; D023181:Antimicrobial Cationic Peptides / Q000097:blood* / Q000172:deficiency; D001327:Autoimmune Diseases / Q000097:blood / Q000175:diagnosis; D015415:Biomarkers / Q000097:blood; D054804:Cathelicidins; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D003937:Diagnosis, Differential; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D006801:Humans; D015151:Immunoblotting; D019272:Leukocyte Elastase / Q000235:genetics; D008297:Male; D009154:Mutation; D009503:Neutropenia / Q000151:congenital / Q000209:etiology* / Q000235:genetics
D023181:Antimicrobial Cationic Peptides; D015415:Biomarkers; D054804:Cathelicidins; D019272:Leukocyte Elastase