title: Confirmation of region-specific patterns of gene expression in the human brain.
abstract: The human brain is divided and categorized in different ways, yet a molecular genetic approach to region specificity does not exist. Using data from 12 healthy control subjects across 18 brain regions, we performed a microarray analysis using both the HG-U133AB and HG-U133 plus 2 chips for each subject to determine molecular targets showing region specificity. Using a previously published data as our guide, we confirm SIX3, GPR6, SH3RF2, and hSyn as molecular markers of the nucleus accumbens and gamma-aminobutyric-acid A receptor alpha-6, Nik-related kinase, and eomesodermin as molecular markers of the cerebellum.
authors: McGill Group for Suicide Studies, McGill University, Montreal, QC, Canada.
authors: Carl
authors: C
authors: Ernst
authors: Adolfo
authors: A
authors: Sequeira
authors: Tim
authors: T
authors: Klempan
authors: Neil
authors: N
authors: Ernst
authors: Jarlath
authors: J
authors: Ffrench-Mullen
authors: Gustavo
authors: G
authors: Turecki
mesh_terms: D001921:Brain / Q000033:anatomy & histology / Q000502:physiology*; D002531:Cerebellum / Q000502:physiology; D004247:DNA / Q000235:genetics*; D015870:Gene Expression; D005819:Genetic Markers; D006801:Humans; D009419:Nerve Tissue Proteins / Q000235:genetics*; D020411:Oligonucleotide Array Sequence Analysis; D011963:Receptors, GABA-A / Q000235:genetics
chemical_list: D005819:Genetic Markers; D009419:Nerve Tissue Proteins; D011963:Receptors, GABA-A; D004247:DNA