title: Reversible posterior leukoencephalopathy syndrome in a patient with multiple system atrophy: a possible association with oral midodrine treatment.
abstract: We describe a 51-year-old man with a 3-year history of multiple system atrophy, who developed a reversible posterior leukoencephalopathy syndrome (RPLS) after receiving prescription midodrine for therapeutic treatment of orthostatic hypotension. Typical reversible magnetic resonance imaging findings, following treatment with midodrine, suggested a possible relationship between midodrine treatment, supine hypertension, and RPLS, although a cause-and-effect relationship cannot be confirmed.
authors: Department of Neurology, The Catholic University of Korea, Seoul, Korea.
authors: Joong-Seok
authors: JS
authors: Kim
authors: Kwang-Soo
authors: KS
authors: Lee
authors: Sung-Chul
authors: SC
authors: Lim
authors: Jae-Young
authors: JY
authors: Ahn
authors: In-Uk
authors: IU
authors: Song
authors: Yeong-In
authors: YI
authors: Kim
authors: Bum-Soo
authors: BS
authors: Kim
authors: Hee-Tae
authors: HT
authors: Kim
mesh_terms: D000316:Adrenergic alpha-Agonists / Q000627:therapeutic use*; D001921:Brain / Q000187:drug effects / Q000473:pathology; D015140:Dementia, Vascular / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D008879:Midodrine / Q000627:therapeutic use*; D019578:Multiple System Atrophy / Q000150:complications* / Q000188:drug therapy*
chemical_list: D000316:Adrenergic alpha-Agonists; D008879:Midodrine