Reversible posterior leukoencephalopathy syndrome in a patient with multiple system atrophy: a possible association with oral midodrine treatment.
We describe a 51-year-old man with a 3-year history of multiple system atrophy, who developed a reversible posterior leukoencephalopathy syndrome (RPLS) after receiving prescription midodrine for therapeutic treatment of orthostatic hypotension. Typical reversible magnetic resonance imaging findings, following treatment with midodrine, suggested a possible relationship between midodrine treatment, supine hypertension, and RPLS, although a cause-and-effect relationship cannot be confirmed.
Kim
Joong-Seok
JS
Department of Neurology, The Catholic University of Korea, Seoul, Korea.
Lee
Kwang-Soo
KS
Lim
Sung-Chul
SC
Ahn
Jae-Young
JY
Song
In-Uk
IU
Kim
Yeong-In
YI
Kim
Bum-Soo
BS
Kim
Hee-Tae
HT
D000316:Adrenergic alpha-Agonists / Q000627:therapeutic use*; D001921:Brain / Q000187:drug effects / Q000473:pathology; D015140:Dementia, Vascular / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D008879:Midodrine / Q000627:therapeutic use*; D019578:Multiple System Atrophy / Q000150:complications* / Q000188:drug therapy*
D000316:Adrenergic alpha-Agonists; D008879:Midodrine