Taenia solium dUTPase: A potential target for anti-human cysticercosis.
dUTPase plays an essential role in pyrimidine metabolism in many organisms. In this study we report the dUTPase-encoding gene (Tdut) from Taenia solium oncospheres and larvae. Alignment reveals that the putative protein contains five conserved motifs that are often found in many characterized dUTPases. The deduced amino acid sequence has only 65.2% identity with human dUTPases. This low identity encourages its use for the design of new drugs against cysticercosis.
Zheng
Yadong
Y
Key Laboratory of Veterinary Parasitology of Gansu Province, State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, CAAS, 1 Xujiaping Road, Lanzhou, Gansu 730046, China. zhyd9@yahoo.com.cn
Luo
Xuenong
X
Liu
Zhenyong
Z
Jing
Zhizhong
Z
Jia
Wanzhong
W
Cai
Xuepeng
X
D000595:Amino Acid Sequence; D000818:Animals; D003551:Cysticercosis / Q000188:drug therapy / Q000209:etiology; D005784:Gene Amplification; D006801:Humans; D010802:Phylogeny; D011755:Pyrophosphatases / Q000145:classification / Q000235:genetics*; D041201:Taenia solium / Q000201:enzymology* / Q000235:genetics
D011755:Pyrophosphatases; C020020:dUTP pyrophosphatase