title: Expression of interleukin 8 in synovial tissues in patients with internal derangement of the temporomandibular joint and its relationship with clinical variables.
abstract: OBJECTIVE
  The objectives of this study were to assay interleukin 8 (IL-8) in synovial tissues of the temporomandibular joint (TMJ) with symptomatic internal derangement, and to assess its relationship with clinical variables.
  
  
  METHODS
  Forty-six joints in 44 patients were examined using an immunohistochemical technique. As controls, 8 joints in 7 subjects with habitual dislocation without pain were also examined.
  
  
  RESULTS
  IL-8 was expressed mainly in the blood vessels beneath the lining cells in 37 of the 46 joints (80%) with internal derangement and in 2 of the 8 control joints. The percentage of IL-8-positive cells was significantly higher in the internal derangement group than in the control group (P = .004). The percentage of IL-8-positive cells showed no correlation with joint pain or number of infiltrating cells.
  
  
  CONCLUSIONS
  IL-8 was up-regulated in inflamed synovial tissues in patients with internal derangement. Because IL-8 has no significant correlation with clinical variables, IL-8 may play a secondary role in the pathogenesis of the internal derangement of the TMJ.
authors: Department of Oral and Maxillofacial Surgery, Kanazawa Medical University, Uchinada-machi and Kita-Ward Sapporo, Japan. jun-s@den.hokudai.ac.jp
authors: Jun
authors: J
authors: Sato
authors: Natsuki
authors: N
authors: Segami
authors: Masaaki
authors: M
authors: Nishimura
authors: Yoshino
authors: Y
authors: Yoshitake
authors: Keiseki
authors: K
authors: Kaneyama
authors: Yoshimasa
authors: Y
authors: Kitagawa
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015703:Antigens, CD / Q000032:analysis; D015214:Antigens, Differentiation, Myelomonocytic / Q000032:analysis; D004812:Epidemiologic Methods; D005260:Female; D006801:Humans; D016209:Interleukin-8 / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D013582:Synovial Fluid / Q000276:immunology*; D019224:Temporomandibular Joint Disc / Q000098:blood supply / Q000276:immunology*; D013705:Temporomandibular Joint Disorders / Q000276:immunology*; D000097382:CD68 Molecule
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D016209:Interleukin-8; C067980:CD68 antigen, human; D000097382:CD68 Molecule