title: Glomerular binding of anti-dsDNA autoantibodies: the dispute resolved?
abstract: The binding of anti-double-stranded DNA (anti-dsDNA) autoantibodies to the glomerular basement membrane (GBM) in lupus nephritis can be explained by two mechanisms: (1) direct crossreactive binding to intrinsic glomerular antigens; (2) nucleosome-mediated binding to heparan sulfate in the GBM. Kalaaji et al. demonstrated using novel techniques that glomerular in vivo-bound antoantibodies bind to nucleosomes/dsDNA derived from apoptotic cells and not to intrinsic glomerular structures.
authors: Nephrology Research Laboratory, Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands.
authors: C C
authors: CC
authors: van Bavel
authors: J
authors: J
authors: van der Vlag
authors: J H
authors: JH
authors: Berden
mesh_terms: D000906:Antibodies / Q000276:immunology*; D001323:Autoantibodies / Q000276:immunology*; D004247:DNA / Q000276:immunology*; D006801:Humans
chemical_list: D000906:Antibodies; D001323:Autoantibodies; C051951:antiglomerular basement membrane antibody; D004247:DNA