title: Does rectus sheath infusion of bupivacaine reduce postoperative opioid requirement?
abstract: BACKGROUND
  The aim of this work was to assess the effect of intermittent bupivacaine infusion into rectus sheath space on postoperative opioid requirement, postoperative pain score and peak expiratory flow rate.
  
  
  METHODS
  A prospective, randomised study involving patients undergoing midline laparotomy. Patients were randomised to receive either intermittent infusion of bupivacaine 0.25% or normal saline via catheters placed in the rectus sheath for 48 h after operation. All patients received intravenous morphine infusion on demand with a patient-controlled analgesic device (PCAD).
  
  
  RESULTS
  Forty ASA I-III patients were studied. Nineteen were randomised to receive bupivacaine and 21 patients received normal saline. Patient characteristics and surgical variables were comparable in the two groups. The mean wound lengths were similar. There was no statistically significant difference in postoperative opioid requirement, postoperative pain score and peak expiratory flow rate between the two groups.
  
  
  CONCLUSIONS
  Intermittent bupivacaine infusion into the rectus sheath space after midline laparotomy does not reduce postoperative opioid requirement nor does it affect postoperative pain score or peak expiratory flow rate.
authors: Department of Surgery, Worthing Hospital, West Sussex, UK. padlu@hotmail.com
authors: J
authors: J
authors: Padmanabhan
authors: A
authors: A
authors: Rohatgi
authors: A
authors: A
authors: Niaz
authors: E
authors: E
authors: Chojnowska
authors: K
authors: K
authors: Baig
authors: W G A
authors: WG
authors: Woods
mesh_terms: D000368:Aged; D016058:Analgesia, Patient-Controlled; D000701:Analgesics, Opioid / Q000008:administration & dosage*; D000774:Anesthesia, Rectal; D000779:Anesthetics, Local / Q000008:administration & dosage*; D002045:Bupivacaine / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D036502:Infusions, Intralesional; D007262:Infusions, Intravenous; D007813:Laparotomy / Q000379:methods; D008297:Male; D009020:Morphine / Q000008:administration & dosage*; D010147:Pain Measurement; D010149:Postoperative Pain / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D010366:Peak Expiratory Flow Rate / Q000187:drug effects; D011446:Prospective Studies
chemical_list: D000701:Analgesics, Opioid; D000779:Anesthetics, Local; D009020:Morphine; D002045:Bupivacaine