title: Association of cervical internal carotid artery aneurysm with ipsilateral vertebrobasilar aneurysm in two children: a segmental entity?
abstract: BACKGROUND
  A combination of cervical and intradural aneurysm in children in the absence of systemic disorders has previously not been reported.
  
  
  METHODS
  We report two boys with an identical combination of fusiform cervical internal carotid aneurysm and ipsilaterally located vertebrobasilar aneurysm. They had no history of trauma, they did not display any personal or familial signs of systemic disease, and the testing for collagen disease was negative. The location and appearance of the aneurysms and the identical anatomical disposition in the patients indicated a non-randomly distributed segmental vulnerability.
  
  
  CONCLUSIONS
  The cases demonstrate primary morphological signs of a developmental error being expressed in two seemingly separate segments but linked by the hypoglossal artery. It suggests a segmental error related to this embryonic vessel. They also show that few phenotypes are specific for a genotypic disorder and highlight the importance of analysing different etiologies for aneurysm formation and anatomical disposition when taking treatment strategy decisions.
authors: Service de Neuroradiologie Diagnostique et Thérapeutique, Hôpital de Bicêtre, 78 Rue du Général Leclerc, 94275, Le Kremlin-Bicêtre, France.
authors: S
authors: S
authors: Holmin
authors: A
authors: A
authors: Ozanne
authors: W Y
authors: WY
authors: Zhao
authors: H
authors: H
authors: Alvarez
authors: T
authors: T
authors: Krings
authors: P
authors: P
authors: Lasjaunias
mesh_terms: D000783:Aneurysm / Q000175:diagnosis* / Q000601:surgery; D001488:Basilar Artery / Q000196:embryology / Q000473:pathology* / Q000601:surgery; D002340:Carotid Artery Diseases / Q000150:complications* / Q000601:surgery; D002343:Carotid Artery, Internal / Q000196:embryology / Q000473:pathology* / Q000601:surgery; D002531:Cerebellum / Q000098:blood supply; D002574:Cervical Vertebrae; D002648:Child; D006801:Humans; D002532:Intracranial Aneurysm / Q000150:complications* / Q000601:surgery; D016896:Treatment Outcome; D014711:Vertebral Artery / Q000196:embryology / Q000473:pathology* / Q000601:surgery