Organocatalytic asymmetric hydrophosphination of nitroalkenes.
The use of a bifunctional Cinchona alkaloid catalyst has provided a new organocatalytic strategy for the enantioselective addition of diphenylphosphine to a range of nitroalkenes, affording optically active beta-nitrophosphines (up to 99% ee after crystallization); this organocatalytic approach, providing a direct route to a new class of potentially useful enantiopure P,N-ligands, constitutes a bridge between the two complementary areas of asymmetric catalysis: organo- and metal-catalyzed transformations.
Bartoli
Giuseppe
G
Dipartimento di Chimica Organica A. Mangini, Alma Mater Studiorum - Università di Bologna, V.le Risorgimento 4 - 40136 Bologna, Italy.
Bosco
Marcella
M
Carlone
Armando
A
Locatelli
Manuela
M
Mazzanti
Andrea
A
Sambri
Letizia
L
Melchiorre
Paolo
P