Argonautes and company: sailing against the wind.
The 3'-untranslated region (UTR) of mRNA is crucial for posttranscriptional regulation. In this issue, Vasudevan and Steitz (2007) report a new function for AGO2 and FXR1--two proteins that have been linked to the regulation of microRNAs and translation repression. AGO2 and FXR1 bind to the AU-rich element in the 3'-UTR of TNFalpha mRNA, unexpectedly activating its translation in a cell growth-dependent manner.
Bhattacharyya
Suvendra N
SN
Friedrich Miescher Institute for Biomedical Research, 4002 Basel, Switzerland.
Filipowicz
Witold
W
D020413:3' Untranslated Regions / Q000235:genetics* / Q000378:metabolism; D060565:Argonaute Proteins; D049109:Cell Proliferation; D015852:Eukaryotic Initiation Factor-2; D005786:Gene Expression Regulation; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism; D010448:Peptide Initiation Factors / Q000378:metabolism*; D014176:Protein Biosynthesis; D016601:RNA-Binding Proteins / Q000378:metabolism*; D038621:Regulatory Sequences, Ribonucleic Acid; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
D020413:3' Untranslated Regions; C466422:AGO2 protein, human; D060565:Argonaute Proteins; D015852:Eukaryotic Initiation Factor-2; C096916:FXR1 protein, human; D035683:MicroRNAs; D010448:Peptide Initiation Factors; D016601:RNA-Binding Proteins; D038621:Regulatory Sequences, Ribonucleic Acid; C439524:TNF protein, human; D014409:Tumor Necrosis Factor-alpha