A haemophagocytic lymphohistiocytosis (HLH)-like picture following breastmilk transmitted cytomegalovirus infection in a preterm infant.
Due to septic illness, neutro- and thrombocytopenia, blocked myelopoiesis, CMV-positive breast milk and CMV-pp65 antigen in bone marrow mononuclear cells, CMV-related HLH was presumed in a breast fed neonate (gestational age 24 weeks). Treatment was successful with foscarnet and methylprednisolone. HLH may be a complication of post-natal CMV-infection acquired from breast milk.
Knorr
Britta
B
Department of Virology, University of Heidelberg, Heidelberg, Germany. britta.knorr@med.uni-heidelberg.de
Kessler
Ulf
U
Pöschl
Johannes
J
Fickenscher
Helmut
H
Linderkamp
Otwin
O
D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use; D003586:Cytomegalovirus Infections / Q000188:drug therapy / Q000635:transmission*; D017245:Foscarnet / Q000627:therapeutic use; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D051359:Lymphohistiocytosis, Hemophagocytic / Q000821:virology*; D008775:Methylprednisolone / Q000627:therapeutic use; D008895:Milk, Human / Q000821:virology*
D000893:Anti-Inflammatory Agents; D000998:Antiviral Agents; D017245:Foscarnet; D008775:Methylprednisolone