Determination of the genetic support for tet(W) in oral bacteria.
The DNA sequence flanking a tet(W) gene in an oral Rothia sp. was determined. The gene was linked to two different transposases, and these were flanked by two almost identical mef (macrolide efflux) genes. This structure was found in 4 out of 20 tet(W)-containing oral bacteria investigated.
Villedieu
A
A
Division of Microbial Diseases, UCL Eastman Dental Institute, 256 Gray's Inn Road, University College London, London WC1X 8LD, United Kingdom.
Roberts
A P
AP
Allan
E
E
Hussain
H
H
McNab
R
R
Spratt
D A
DA
Wilson
M
M
Mullany
P
P
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001426:Bacterial Proteins / Q000235:genetics* / Q000378:metabolism; D004251:DNA Transposable Elements; D006801:Humans; D008565:Membrane Proteins; D008835:Micrococcaceae / Q000187:drug effects* / Q000235:genetics*; D009055:Mouth / Q000382:microbiology*; D013752:Tetracycline / Q000494:pharmacology; D013753:Tetracycline Resistance / Q000235:genetics*; D019895:Transposases / Q000235:genetics
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D004251:DNA Transposable Elements; C117866:MefA protein, Streptococcus; D008565:Membrane Proteins; D019895:Transposases; D013752:Tetracycline