Antitumor efficacy of poly(dimer acid-dodecanedioic acid) copolymer in mice bearing Sarcoma-180 tumor.
The drug release profiles of poly(dimer acid-dodecanedioic acid) P(DA-DDDA) copolymer containing 5% adriamycin hydrochloride (ADM) in vitro were evaluated. The biocompatibility of P(DA-DDDA) under mice skin was also evaluated, macroscopic observation and microscopic analysis demonstrated that the copolymer is biocompatible and well tolerated in vivo. Antitumor efficacy of P(DA-DDDA) copolymers containing 5% adriamycin hydrochloride (ADM) implanted subcutaneously in mice bearing Sarcoma-180 tumor exhibited increased volume doubling time (VDT) (31 +/- 1.5 days) compared to plain subcutaneous injection of ADM (7 +/- 0.9 days). The studies suggest that P(DA-DDDA) copolymer as an effective carrier for antineoplastic drug like adriamycin hydrochloride has a very good prospect in the treatment of noumenon tumors.
Guo
Wen-Xun
WX
College of Materials Science and Engineering, Hunan University, Changsha, Hunan 410082, P.R. China. guowenxun@126.com
Shi
Zongli
Z
Zeng
Fan-Bing
FB
Liang
Kui
K
Chen
Xian-Hong
XH
Ai
Yong-Ping
YP
Fang
Min
M
Sun
Xiao
X
Zhang
Zhi
Z
Hu
Li-Xin
LX
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D003692:Delayed-Action Preparations / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D003998:Dicarboxylic Acids / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D004058:Diffusion; D004317:Doxorubicin / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D004339:Drug Compounding / Q000379:methods; D004343:Drug Implants; D007279:Injections, Subcutaneous; D008422:Materials Testing; D051379:Mice; D011108:Polymers / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D012509:Sarcoma / Q000188:drug therapy* / Q000473:pathology*; D016896:Treatment Outcome
D000903:Antibiotics, Antineoplastic; D003692:Delayed-Action Preparations; D003998:Dicarboxylic Acids; D004343:Drug Implants; D011108:Polymers; C523614:poly(dimer acid-dodecanedioic acid) copolymer; D004317:Doxorubicin