title: Fistula size and hemodynamics: an experimental model in canine femoral arteriovenous fistulas.
abstract: OBJECTIVE
  The objective was to evaluate the impact of anastomosis diameter on blood flow in an arteriovenous fistula (AVF), comparing two different anastomosis sizes with a modified side-to-side technique in canine femoral arteries.
  
  
  METHODS
  Ten mongrel dogs were subjected to two AVFs each, both using a modified side-to-side technique. On one side, the anastomosis diameter was 1.5 times the arterial diameter and on the other side 3.0 times the arterial diameter. Mean proximal and caudal blood flow and mean venous flow were measured using an electronic flowmeter 15, 20 and 25 min after surgery. The Mann-Whitney, Friedman and Wilcoxon non-parametric tests were used for data analysis (alpha < or = 0.05).
  
  
  RESULTS
  Femoral artery flow cranial to the fistula became 5.6 times greater in the 1.5 arterial diameter group, and 8.4 times greater in the 3.0 arterial diameter group, when compared to initial arterial flow. The mean flow in the cranial vein was greater in the 3.0 group (10.09 times greater vs. 6.46 times greater in the 1.5 group). Both in the proximal artery and in the vein there was a significantly greater flow in the group with the larger anastomosis diameter (Wilcoxon test). In the femoral artery caudal to the fistula, the flow in most of the animals was reversed: 3.5 times greater in the 1.5 group and 1.2 times greater in the 3.0 group, without statistical difference.
  
  
  CONCLUSIONS
  These results suggest that 3.0 times the arterial diameter for the AVF size in dogs leads to greater venous flow than with 1.5 times the arterial diameter, without increasing the reversed flow.
authors: Hospital e Maternidade Dr Christóvão da Gama, Santo André, São Paulo, Brazil. eramacciotti@yahoo.com
authors: E
authors: E
authors: Ramacciotti
authors: S J
authors: SJ
authors: Galego
authors: M
authors: M
authors: Gomes
authors: S
authors: S
authors: Goldenberg
authors: P
authors: P
authors: De Oliveira Gomes
authors: J
authors: J
authors: Pinto Ortiz
mesh_terms: D000818:Animals; D001163:Arteriovenous Anastomosis / Q000601:surgery*; D001166:Arteriovenous Shunt, Surgical / Q000379:methods*; D004195:Disease Models, Animal; D004285:Dogs; D005263:Femoral Artery / Q000502:physiology / Q000601:surgery*; D005268:Femoral Vein / Q000502:physiology / Q000601:surgery; D008297:Male; D012039:Regional Blood Flow