title: Genomic alterations in low-grade, anaplastic astrocytomas and glioblastomas.
abstract: To extend our understanding of potential stepwise genetic alterations that may underlie tumor progression from low-grade astrocytomas to glioblastomas, histopathologic and comparative genomic hybridization analyses were performed on tumor specimens from 68 primary lesions, including 40 glioblastomas, 10 anaplastic and 18 low-grade astrocytomas. The number of aberrations per case increased towards the higher grade tumors (grade II: 1.66+/-1.49; grade III: 2.80+/-1.68; grade IV: 3.02+/-1.07; F=6.955, p=0.002). A gain of 7/7q was common and the most frequently seen aberration in low-grade astrocytomas, whereas loss of 10q was the most frequently seen anomaly in anaplastic astrocytomas and glioblastomas. Chromosome 7p amplification was only detected in glioblastomas. Chromosome 10/10q deletion and combination of 1p, 19q and 17p deletions were specific to high-grade astrocytic tumors. Sequences of chromosome 7 and 10 seem to have pivotal roles in the biology of human gliomas. The genomic copy deletions of chromosomes 1p and 19q might provide an alternative mechanism in the genesis of astrocytomas.
authors: Department of Neurosurgery, Medical Faculty, Osmangazi University, Eskisehir, Turkey. aali@ogu.edu.tr
authors: Ali
authors: A
authors: Arslantas
authors: Sevilhan
authors: S
authors: Artan
authors: Ulkü
authors: U
authors: Oner
authors: M Hamza
authors: MH
authors: Müslümanoglu
authors: Muhsin
authors: M
authors: Ozdemir
authors: Ramazan
authors: R
authors: Durmaz
authors: Didem
authors: D
authors: Arslantas
authors: Murat
authors: M
authors: Vural
authors: Erhan
authors: E
authors: Cosan
authors: Metin Ant
authors: MA
authors: Atasoy
mesh_terms: D000328:Adult; D000368:Aged; D001254:Astrocytoma / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology; D001932:Brain Neoplasms / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology; D002869:Chromosome Aberrations; D002872:Chromosome Deletion; D005260:Female; D005909:Glioblastoma / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis