Activation of maternal behavior of albino rats after combined treatment with dopamine and opioid receptor antagonists in low doses.
We studied the effect of D1/D2 antagonist haloperidol on maternal motivation in nursing albino rats. Haloperidol in a dose of 0.2 mg/kg significantly attenuated parental reactions and motor and exploratory activities. In a lower dose (0.1 mg/kg) the drug produced the same effect on maternal behavior (number of approaches to newborns) without reducing motor activity. The effect of low-dose haloperidol was different after naloxone treatment (0.2 mg/kg intranasally): the number of pup transfers increased significantly. The detected phenomenon indicates good prospects of combined treatment with agents modifying the cerebral dopaminergic and opioid systems as the method for correction of disorders in maternal behavior.
Dobryakova
Yu V
YV
Department of Human and Animal Physiology, Biological Faculty, M. V. Lomonosov Moscow State University.
Belyaeva
Yu A
YA
Stovolosov
I S
IS
Dubynin
V A
VA
Kamenskii
A A
AA
D000704:Analysis of Variance; D000818:Animals; D018492:Dopamine Antagonists / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005106:Exploratory Behavior / Q000187:drug effects; D005260:Female; D006220:Haloperidol / Q000494:pharmacology*; D008425:Maternal Behavior / Q000187:drug effects*; D009043:Motor Activity / Q000187:drug effects; D009270:Naloxone / Q000494:pharmacology*; D009292:Narcotic Antagonists; D051381:Rats
D018492:Dopamine Antagonists; D009292:Narcotic Antagonists; D009270:Naloxone; D006220:Haloperidol