title: Preparation and properties of modified chitosan as potential matrix materials for drug sustained-release beads.
abstract: Modified chitosan such as chitosan alpha-ketoglutaric acid (KCTS) and hydroxamated chitosan alpha-ketoglutaric acid (HKCTS) were successfully prepared. The modified chitosan were employed in the formation of drug-loaded, iron(III)-crosslinked polymeric beads. The produced polymers were characterized by IR, NMR, WXRD and DSC measurements. The resulting beads were evaluated in vitro as drug prolonging and potentially orally administered delivery system. Theophylline was used as the loaded model drug. The generated beads proved to be successful in prolonging drug release. The release kinetics was evaluated by fitting the experimental data to standard release equations (zero-, first- and Higuchi equation). The best fit was found with Higuchi model for the polymeric beads.
authors: College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, PR China.
authors: Ping
authors: P
authors: Ding
authors: Ke-Long
authors: KL
authors: Huang
authors: Gui-Yin
authors: GY
authors: Li
authors: Yan-Fei
authors: YF
authors: Liu
mesh_terms: D002626:Chemistry, Pharmaceutical; D048271:Chitosan / Q000737:chemistry*; D003692:Delayed-Action Preparations / Q000138:chemical synthesis / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry; D007656:Ketoglutaric Acids / Q000737:chemistry*; D008956:Models, Chemical; D011108:Polymers; D013806:Theophylline / Q000737:chemistry*
chemical_list: D003692:Delayed-Action Preparations; D004337:Drug Carriers; D007656:Ketoglutaric Acids; D011108:Polymers; D048271:Chitosan; D013806:Theophylline