title: Spectrum of FGFR3 mutations in multiple intraindividual seborrheic keratoses.
abstract: Somatic FGFR3 mutations have recently been identified in seborrheic keratoses (SK). Affected individuals often show a large number of SK, but their spectrum of FGFR3 mutations has not been investigated yet. We analyzed 78 SK of four patients using a SNaPshot multiplex assay. FGFR3 mutations were detected in 46 of 78 SK (59%). The mutation rates of the patients ranged from 26 to 89%. Each patient showed at least four different mutated loci. FGFR3 mutations appear to be common genetic alterations in multiple SK with a varying interindividual mutation frequency but without specific intraindividual hot spots.
authors: Department of Dermatology, University of Regensburg, Regensburg, Germany. christian.hafner@klinik.uni-regensburg.de
authors: Christian
authors: C
authors: Hafner
authors: Arndt
authors: A
authors: Hartmann
authors: Francisco X
authors: FX
authors: Real
authors: Ferdinand
authors: F
authors: Hofstaedter
authors: Michael
authors: M
authors: Landthaler
authors: Thomas
authors: T
authors: Vogt
mesh_terms: D006801:Humans; D017492:Keratosis, Seborrheic / Q000235:genetics*; D009154:Mutation; D051498:Receptor, Fibroblast Growth Factor, Type 3 / Q000378:metabolism*
chemical_list: D051498:Receptor, Fibroblast Growth Factor, Type 3