title: Surgical treatment of pancreatic endocrine neoplasms.
abstract: BACKGROUND
  Pancreatic endocrine neoplasia (PEN) is an entity with an indolent course and prolonged survival. The aim of the current study was to review the prognostic factors and outcome of patients with PEN at 1 institution.
  
  
  METHODS
  Records of patients with the diagnosis of PEN in the period of 1980 to 2001 were reviewed. Descriptive statistics and log-rank test were used; significance was defined as P < .05.
  
  
  RESULTS
  Of 49 patients, 25 had functional and 24 nonfunctional tumors. Surgery was performed in 43 patients, 36 with curative intent. With a median follow-up of 31 months, there were 5 deaths. Symptoms were controlled with surgical resection in 86%. Median disease-free survival (DFS) was 46 months; actuarial 5-year disease-specific (DSS) was 72%. Factors associated with better DFS and DSS were absence of liver involvement (P = .02) and resection of the primary tumor (P = .04).
  
  
  CONCLUSIONS
  Surgical resection and absence of liver metastases are associated with better DFS and DSS in patients with PEN.
authors: Section of Surgical Oncology, Department of Surgery, University of Alabama at Birmingham, 1922 7th Avenue South, Room 321, Birmingham, AL 35294, USA.
authors: Fernando
authors: F
authors: Gomez-Rivera
authors: Ashley E
authors: AE
authors: Stewart
authors: J Pablo
authors: JP
authors: Arnoletti
authors: Selwyn
authors: S
authors: Vickers
authors: Kirby I
authors: KI
authors: Bland
authors: Martin J
authors: MJ
authors: Heslin
mesh_terms: D004701:Endocrine Gland Neoplasms / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010180:Pancreatectomy; D010190:Pancreatic Neoplasms / Q000601:surgery*; D011379:Prognosis; D016019:Survival Analysis; D016896:Treatment Outcome