title: Relationships between brain natriuretic peptide, troponin I and QT dispersion in asymptomatic dialysis patients.
abstract: OBJECTIVE
  The relationships between increased wall stress, myocyte death, and ventricular repolarization instability in patients with heart failure were reported.
  
  
  METHODS
  The relationships between brain natriuretic peptide (BNP), a predictor of increased wall stress of hearth; troponin I (cTnI), a predictor of myocyte death; and QT dispersion (QTd), a reflection of ventricular repolarization instability were evaluated in age- and sex-matched asymptomatic 29 hemodialysis (HD) patients and 26 peritoneal dialysis (PD) patients, and the finding were compared.
  
  
  RESULTS
  Serum BNP and cTnI levels in HD patients (722.9 +/- 907.9 pg/mL, 0.05 +/- 0.07 microg/L, respectively), just before HD, were significantly higher than those of PD patients (255.4 +/- 463.7 pg/mL, 0.02 +/- 0.02 microg/L, respectively; p < 0.05). There was no significant difference between groups with regard to corrected QTd and maximum and minimum QT intervals (p > 0.05). Serum cTnI levels were significantly and positively correlated with serum BNP levels in both dialysis groups (r = 0.447, p = 0.048). No relationship was found between plasma BNP and ECG parameters studied in both groups (p > 0.05).
  
  
  CONCLUSIONS
  Increased serum cTnI levels were associated with elevated BNP levels in both dialysis groups. The increases in BNP and troponin I are more likely to reflect hypervolemia. Although CAPD patients were receiving dialysis daily and HD patients were more hypervolemic, CAPD patients have similar QTdc and accordingly a similar tendency toward arrhythmias. This suggests that factors other than electromechanical interaction may be important in determining the QT interval length in patients on dialysis.
authors: Biochemistry Department, Turgut Ozal Medical Center of Inonu University Medical Faculty, Malatya, Turkey. taskapanmc@yahoo.com
authors: M Cagatay
authors: MC
authors: Taskapan
authors: Hulya
authors: H
authors: Taskapan
authors: Ozkan
authors: O
authors: Ulutas
authors: Mesut
authors: M
authors: Orhan
authors: Ibrahim
authors: I
authors: Sahin
mesh_terms: D000328:Adult; D001145:Arrhythmias, Cardiac / Q000097:blood / Q000453:epidemiology; D001806:Blood Urea Nitrogen; D003404:Creatinine / Q000097:blood; D006334:Heart Function Tests; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000503:physiopathology / Q000628:therapy*; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010531:Peritoneal Dialysis, Continuous Ambulatory; D006435:Renal Dialysis; D019210:Troponin I / Q000097:blood*
chemical_list: D019210:Troponin I; D020097:Natriuretic Peptide, Brain; D003404:Creatinine