In vitro activities of miltefosine and two novel antifungal biscationic salts against a panel of 77 dermatophytes.
The susceptibilities of 77 dermatophytes to miltefosine (MI), 1,12-bis(4-pentylpyridinium)dodecane (PYR), 1,12-bis(tributylammonium)dodecane (AM), itraconazole (ITC), terbinafine (TRB), and butenafine (BTF) were compared. Geometric mean MICs of TRB, BTF, ITC, MI, PYR, and AM were 0.039, 0.059, 1.718, 0.671, 6.006, and 4.771 microg/ml, respectively. MI was more active than ITC (P < 0.001).
Tong
Zhongsheng
Z
Centre for Infectious Diseases and Microbiology Laboratory, Westmead Hospital, Westmead, New South Wales 2145, Australia.
Widmer
Fred
F
Sorrell
Tania C
TC
Guse
Zofia
Z
Jolliffe
Katrina A
KA
Halliday
Catriona
C
Lee
Ok Cha
OC
Kong
Fanrong
F
Wright
Lesley C
LC
Chen
Sharon C A
SC
D000935:Antifungal Agents / Q000494:pharmacology*; D003883:Arthrodermataceae / Q000145:classification / Q000187:drug effects*; D002412:Cations / Q000737:chemistry / Q000494:pharmacology; D002712:Chlorides / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D010767:Phosphorylcholine / Q000031:analogs & derivatives* / Q000494:pharmacology; D011726:Pyridinium Compounds / Q000737:chemistry / Q000494:pharmacology*; D000644:Quaternary Ammonium Compounds / Q000737:chemistry / Q000494:pharmacology*
D000935:Antifungal Agents; D002412:Cations; D002712:Chlorides; D011726:Pyridinium Compounds; D000644:Quaternary Ammonium Compounds; D010767:Phosphorylcholine; C039128:miltefosine