Telomerase unplugged.
The control of telomerase activity at chromosome ends by telomere-binding proteins is critical for telomere length homeostasis. Two recent papers identify TPP1 as a critical mediator of this control. TPP1 forms part of the telomeric shelterin complex while also associating with telomerase, stimulating its activity and processivity.
Cristofari
Gaël
G
Swiss Institute for Experimental Cancer Research, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
Sikora
Katarzyna
K
Lingner
Joachim
J
D006801:Humans; D046912:Multiprotein Complexes / Q000502:physiology; D000089804:Shelterin Complex; D019098:Telomerase / Q000378:metabolism*; D034501:Telomere-Binding Proteins / Q000378:metabolism* / Q000502:physiology
C495876:ACD protein, human; D046912:Multiprotein Complexes; C440849:POT1 protein, human; D000089804:Shelterin Complex; C440868:TINF2 protein, human; D034501:Telomere-Binding Proteins; D019098:Telomerase