CYP2B6 983T>C polymorphism is prevalent in West Africa but absent in Papua New Guinea: implications for HIV/AIDS treatment.
OBJECTIVE
To determine the prevalence of the novel CYP2B6 functional polymorphism 983T>C in Papua New Guinea where HIV/AIDS poses a significant health problem.


METHODS
We genotyped Papua New Guineans (PNG, n = 174), West Africans (WA, n = 170), and North Americans (NA, n = 361).


RESULTS
The polymorphism was absent in PNG, while its overall frequency was 4.7% in WA. Among NA, the polymorphism was present in African-Americans (7.5%) and Hispanic-Americans (1.1%) but not in Caucasian-Americans and Asian-Americans. Haplotype analysis indicated that 983T>C was present alone as the CYP2B6*18 allele in WA and African-Americans.


CONCLUSIONS
Significant interethnic differences occur at the CYP2B6 locus, which may influence treatment outcomes with efavirenz.
Mehlotra
Rajeev K
RK
Center for Global Health and Diseases, Case Western Reserve University, School of Medicine, Cleveland, OH, USA.
Bockarie
Moses J
MJ
Zimmerman
Peter A
PA
D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy / Q000235:genetics; D001741:Black or African American; D000480:Alkynes; D000483:Alleles; D019380:Anti-HIV Agents / Q000627:therapeutic use; D001189:Aryl Hydrocarbon Hydroxylases / Q000235:genetics*; D048588:Benzoxazines / Q000627:therapeutic use; D003521:Cyclopropanes; D065702:Cytochrome P-450 CYP2B6; D005838:Genotype; D015658:HIV Infections / Q000188:drug therapy; D006239:Haplotypes; D006801:Humans; D010089:Oxidoreductases, N-Demethylating / Q000235:genetics*; D010219:Papua New Guinea / Q000208:ethnology; D020641:Polymorphism, Single Nucleotide; D044382:Population Groups; D014481:United States / Q000208:ethnology
D000480:Alkynes; D019380:Anti-HIV Agents; D048588:Benzoxazines; D003521:Cyclopropanes; D001189:Aryl Hydrocarbon Hydroxylases; C585599:CYP2B6 protein, human; D065702:Cytochrome P-450 CYP2B6; D010089:Oxidoreductases, N-Demethylating; C098320:efavirenz