title: Oxytocin infusion in laparoscopic myomectomy may decrease operative blood loss.
abstract: OBJECTIVE
  To evaluate the influence of oxytocin on operative blood loss during laparoscopic myomectomy (LM).
  
  
  METHODS
  Prospective clinical study (Canadian Task Force classification I).
  
  
  METHODS
  Tertiary care university hospital.
  
  
  METHODS
  Sixty women scheduled for myomectomy because of symptomatic uterine myomas.
  
  
  METHODS
  Two ampules of oxytocin (10 u/mL/amp) were added to 1000 mL of saline solution running at the rate of 40 mU/min during the course of LM.
  
  
  RESULTS
  Blood loss and blood transfusion rate were significantly greater in the group without oxytocin infusion (group B) than in the group with oxytocin infusion (group A), with 445.0 +/- 268.6 mL (95% CI 344.7-545.3) versus 269.5 +/- 225.8 mL (95% CI 185.2-353.8)/(p <.05), and 36.7% versus 6.7% (p <.05), respectively. There was no significant difference in average age, body weight, or numbers of vaginal delivery and cesarean sections between the 2 groups. There was no significant difference in mean total myoma weight, main myoma size, postoperative stay, and complications between the 2 groups.
  
  
  CONCLUSIONS
  Oxytocin infusion combined with skillful surgical techniques may decrease operative blood loss and blood transfusion during LM.
authors: Department of Obstetrics and Gynecology, Division of Gynecologic Endoscopy, Chang Gung Memorial Hospital, Linkou Medical Center and Chang Gung University College of Medicine, Kwei-Shan, Tao-Yuan, Taiwan. wang2260@cgmh.org.tw
authors: Chin-Jung
authors: CJ
authors: Wang
authors: Chyi-Long
authors: CL
authors: Lee
authors: Leung-To
authors: LT
authors: Yuen
authors: Nari
authors: N
authors: Kay
authors: Chien-Min
authors: CM
authors: Han
authors: Yung-Kuei
authors: YK
authors: Soong
mesh_terms: D000328:Adult; D016063:Blood Loss, Surgical / Q000517:prevention & control*; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D010535:Laparoscopy / Q000009:adverse effects*; D018231:Leiomyomatosis / Q000601:surgery*; D010120:Oxytocics / Q000008:administration & dosage / Q000627:therapeutic use*; D010121:Oxytocin / Q000008:administration & dosage / Q000627:therapeutic use*; D011446:Prospective Studies; D014594:Uterine Neoplasms / Q000601:surgery*
chemical_list: D010120:Oxytocics; D010121:Oxytocin