How Glycosylphosphatidylinositol-phospholipase D acts in homing of hematopoietic stem/progenitor cells?
Homing of hematopoietic stem/progenitor cells (HS/PC) to the bone marrow (BM) microenvironment is the first and essential step in HS/PC engraftment and initiation of the marrow reconstitution during clinical hematopoietic stem cell transplantation (HSCT). How to improve the homing efficiencies and make full use of HS/PC resources, especially umbilical cord blood (UCB), are of great importance in clinical practice. However, the cellular and molecular mechanisms that govern this process are poorly understood. Glycosylphosphatidylinositol-phospholipase D (GPI-PLD) is an enzyme which can regulate the expression of Glycosylphosphatidylinositol (GPI)-anchored proteins and modulate their correspondent functions by releasing GPI-anchored proteins from cell membrane. Recent studies suggested that the mechanisms of the malignancy and prognosis of certain tumors were correlated with GPI-PLD. HS/PC homing was similar to tumor invasion and metastasis in some process. Here we proposed the hypothesis that GPI-PLD might also has played a role in the homing of HS/PC by modulating the adhesion and migration of these cells. If GPI-PLD did participate in HS/PC homing, maybe the mechanisms of homing can herefrom be partly elucidated, which would benefit transplantation in clinical practice.
Song
Kui
K
Department of Hematology, Xiang Ya Hospital, Central South University, ChangSha 410008, PR China.
Sun
Xiaojuan
X
Wang
Jun
J
Chen
Fangping
F
D000818:Animals; D001853:Bone Marrow / Q000378:metabolism; D017690:Cell Transplantation; D018819:Dipeptidyl Peptidase 4 / Q000096:biosynthesis; D017261:Glycosylphosphatidylinositols / Q000378:metabolism*; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D006413:Hematopoietic System / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000473:pathology; D010739:Phospholipase D / Q000378:metabolism*; D011379:Prognosis; D013234:Stem Cells / Q000166:cytology*; D013499:Surface Properties
D017261:Glycosylphosphatidylinositols; D010739:Phospholipase D; D018819:Dipeptidyl Peptidase 4