title: Comparison of lactated Ringer's solution and 0.9% saline in the treatment of rhabdomyolysis induced by doxylamine intoxication.
abstract: OBJECTIVE
  To compare the effectiveness and side effects of lactated Ringer's solution (LR) and 0.9% saline (NS) in the treatment of rhabdomyolysis induced by doxylamine intoxication.
  
  
  METHODS
  In this 15-month-long prospective randomised single-blind study, after excluding 8 patients among 97 doxylamine-intoxicated patients, 28 (31%) patients were found to have developed rhabdomyolysis and were randomly allocated to NS group (n = 15) or LR group (n = 13).
  
  
  RESULTS
  After 12 h of aggressive hydration (400 ml/h), urine/serum pH was found to be significantly higher in the LR group, and serum Na+/Cl- levels to be significantly higher in the NS group. There were no significant differences in serum K+ level and in the time taken for creatine kinase normalisation. The amount of sodium bicarbonate administered and the frequency administration of diuretics was significantly higher in the NS group. Unlike the NS group, the LR group needed little supplemental sodium bicarbonate and did not develop metabolic acidosis.
  
  
  CONCLUSIONS
  LR is more useful than NS in the treatment of rhabdomyolysis induced by doxylamine intoxication.
authors: Department of Emergency Medicine, Soonchunhyang University Bucheon Hospital, 1174, Jung-dong, Wonmi-gu, Bucheon-si, Gyeonggi-do 420-020, Republic of Korea. choyoungsoon@hanafos.com
authors: Young Soon
authors: YS
authors: Cho
authors: Hoon
authors: H
authors: Lim
authors: Seung Ho
authors: SH
authors: Kim
mesh_terms: D000328:Adult; D004319:Doxylamine / Q000506:poisoning*; D005260:Female; D005440:Fluid Therapy / Q000379:methods*; D006634:Histamine H1 Antagonists / Q000506:poisoning*; D006801:Humans; D007552:Isotonic Solutions / Q000627:therapeutic use*; D008297:Male; D011446:Prospective Studies; D012206:Rhabdomyolysis / Q000139:chemically induced* / Q000628:therapy*; D000077325:Ringer's Lactate; D016037:Single-Blind Method; D012965:Sodium Chloride / Q000627:therapeutic use*; D018709:Statistics, Nonparametric; D016896:Treatment Outcome
chemical_list: D006634:Histamine H1 Antagonists; D007552:Isotonic Solutions; D000077325:Ringer's Lactate; D012965:Sodium Chloride; D004319:Doxylamine