Premotor cortex modulates somatosensory cortex during voluntary movements without proprioceptive feedback.
Movement perception relies on sensory feedback, but the involvement of efference copies remains unclear. We investigated movements without proprioceptive feedback using ischemic nerve block during fMRI in healthy humans, and found preserved activation of the primary somatosensory cortex. This activation was associated with increased interaction with premotor cortex during voluntary movements, which demonstrates that perception of movements relies in part on predictions of sensory consequences of voluntary movements that are mediated by the premotor cortex.
Christensen
Mark Schram
MS
Department of Exercise and Sport Sciences, University of Copenhagen, Blegdamsvej 3, Panum Institute 24.6, DK-2200 Copenhagen, Denmark. markc@drcmr.dk
Lundbye-Jensen
Jesper
J
Geertsen
Svend Sparre
SS
Petersen
Tue Hvass
TH
Paulson
Olaf B
OB
Nielsen
Jens Bo
JB
D000328:Adult; D001931:Brain Mapping; D004562:Electrocardiography / Q000379:methods; D005073:Evoked Potentials, Somatosensory; D005246:Feedback; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D016014:Linear Models; D008297:Male; D009044:Motor Cortex / Q000502:physiology*; D009068:Movement; D010100:Oxygen / Q000097:blood; D010775:Photic Stimulation / Q000379:methods; D011597:Psychomotor Performance; D013003:Somatosensory Cortex / Q000098:blood supply / Q000502:physiology*
D010100:Oxygen