High positivity of anti-CCP antibodies in patients with Down syndrome.
The aim of the present study was to evaluate the prevalence of anti-cyclic citrullinated peptide (CCP) antibodies in patients with Down's syndrome (DS) previously tested for IgM rheumatoid factor (RF) and to correlate the results with clinical findings. Eighty-eight patients with DS previously tested for IgM-RF were divided into two groups matched for sex and age. Group A consists of 42 RF positive patients and group B of 44 RF negative patients. The presence of anti-CCP antibody was determined using a second-generation enzyme-linked immunosorbent assay. A total of 52.3% (45/86) of DS patients were positive for anti-CCP antibodies. Twenty-four patients (57.1%) of the RF positive group and 21 (47.7%) of the RF negative group presented anti-CCP circulating antibodies. The concordance between both tests was 54.6%. None of the patients had clinical evidence of rheumatoid arthritis or juvenile idiopathic arthritis. Although a high prevalence of anti-CCP antibodies was observed in DS patients, no association has been found presently with clinical disease. Careful follow-up of these patients will be necessary to clarify the real significance of these findings.
Nisihara
Renato M
RM
Laboratory of Immunopathology, Department of Clinical Pathology, Clinical Hospital, Federal University of Paraná, Curitiba, Brazil. renatomitsu@yahoo.com.br.|, Ave. Arthur da Silva Bernardes, 753, Curitiba, Paraná, Brazil, 80 320 300. renatomitsu@yahoo.com.br.
Skare
Thelma L
TL
Rheumatology Clinic, Evangelic University Hospital of Curitiba, Curitiba, Brazil.
Silva
Marília B G
MBG
Rheumatology Clinic, Evangelic University Hospital of Curitiba, Curitiba, Brazil.
Messias-Reason
Iara T
IT
Laboratory of Immunopathology, Department of Clinical Pathology, Clinical Hospital, Federal University of Paraná, Curitiba, Brazil.
Oliveira
Nanci P
NP
Down syndrome Clinic, Clinical Hospital, Federal University of Paraná, Curitiba, Brazil.
Fiedler
Patricia T
PT
Down syndrome Clinic, Clinical Hospital, Federal University of Paraná, Curitiba, Brazil.
Utiyama
Shirley R R
SRR
Laboratory of Immunopathology, Department of Clinical Pathology, Clinical Hospital, Federal University of Paraná, Curitiba, Brazil.
D000293:Adolescent; D000328:Adult; D000888:Antibodies, Anti-Idiotypic / Q000276:immunology; D001172:Arthritis, Rheumatoid / Q000150:complications / Q000175:diagnosis / Q000276:immunology*; D001323:Autoantibodies / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D004314:Down Syndrome / Q000150:complications / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007075:Immunoglobulin M / Q000276:immunology; D008297:Male; D008875:Middle Aged; D010456:Peptides, Cyclic / Q000276:immunology*; D012217:Rheumatoid Factor / Q000276:immunology*
D000888:Antibodies, Anti-Idiotypic; D001323:Autoantibodies; D007075:Immunoglobulin M; D010456:Peptides, Cyclic; C487763:cyclic citrullinated peptide; D012217:Rheumatoid Factor