Development of self-expandable covered stents.
We newly developed self-expandable covered stents by combining two of our original technologies. Of these, the first is the dip-coating covering method that was developed previously for balloon-expandable stents; the other is the newly developed self-expandable Nitinol stents, namely, Sendai stents. The three types of covered stents with the expansion diameter of 4.5, 5.0, or 6.0 mm thus obtained had a laser-processed microporous elastomeric cover film (pore diameter: 100 microm, interpore distance: 250 microm). Although the film was extremely thin (approximately 15 microm), the film could be expanded without causing any damage, the strut was completely embedded within the film, and the luminal surface of the film was smooth and flat. Mechanical properties such as ideal flexibility to follow the shapes of arteries were almost retained even after covering. As appropriate drugs, the blood-contacting inner and tissue-contacting outer surfaces of the film were differentially coated with argatroban for antithrombogenicity or FK506 for anti-inflammation, respectively. The preliminary in vivo study indicated that the covered stents mounted in the delivery catheter were navigated and placed to appropriate position in the arteries, and permissible neointimal thickening after 1-month implantation was observed similarly in noncovered stents.
Sato
Sachiko
S
Department of Diagnostic Radiology, Graduate School of Medicine, Tohoku University, 1-1 Seiryo, Sendai, Miyagi 980-8574, Japan.
Nakayama
Yasuhide
Y
Miura
Yoshihiro
Y
Okamoto
Yoshihiro
Y
Asano
Hiroyuki
H
Ishibashi-Ueda
Hatsue
H
Zhou
Yue-Min
YM
Hayashida
Kyoko
K
Matsuhashi
Toshio
T
Seiji
Kazumasa
K
Sato
Akihiro
A
Yamada
Takayuki
T
Takahashi
Shoki
S
Ishibashi
Tadashi
T
D000497:Alloys / Q000737:chemistry*; D000792:Angiography; D000818:Animals; D000925:Anticoagulants / Q000008:administration & dosage; D001120:Arginine / Q000031:analogs & derivatives; D001807:Blood Vessel Prosthesis; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D004285:Dogs; D004343:Drug Implants / Q000737:chemistry*; D004548:Elasticity; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D010875:Pipecolic Acids / Q000008:administration & dosage; D011474:Prosthesis Design; D015607:Stents; D013449:Sulfonamides; D016559:Tacrolimus / Q000008:administration & dosage
D000497:Alloys; D000925:Anticoagulants; D020099:Coated Materials, Biocompatible; D004343:Drug Implants; D007166:Immunosuppressive Agents; D010875:Pipecolic Acids; D013449:Sulfonamides; C013616:nitinol; D001120:Arginine; C031942:argatroban; D016559:Tacrolimus