title: Relationship between serum levels of some acute-phase proteins and stage of disease and performance status in patients with lung cancer.
abstract: BACKGROUND
  Lung cancer is the leading cause of cancer death in both developed and developing countries. The aim of the present study was to compare serum levels of alpha1-acid glycoprotein, ceruloplasmin, transferrin, ferritin, and albumin with tumor stage, distant metastasis, lymphadenopa thy, and patient performance status in patients with non-small-cell lung cancer and those with small-cell lung cancer.
  
  
  METHODS
  The study was carried out in 46 patients with primary lung cancer (39 men and 7 women) and 34 healthy subjects as the control group.
  
  
  RESULTS
  Serum ceruloplasmin and ferritin levels were higher and transferrin and albumin levels were lower both in non-small-cell and small-cell lung cancer patients than in controls. The levels of alpha1-acid glycoprotein and ferritin associated with both performance status and lymph node metastasis.
  
  
  CONCLUSIONS
  Measurement of alpha1-acid glycoprotein and ferritin levels could be a useful prognostic factor in addition to performance status in patient with primary lung cancer.
authors: Department of Biochemistry, School of Medicine, Ataturk University, Erzurum, Turkey. kadir@atauni.edu.tr
authors: Abdulkadir
authors: A
authors: Yildirim
authors: Mehmet
authors: M
authors: Meral
authors: Hasan
authors: H
authors: Kaynar
authors: Harun
authors: H
authors: Polat
authors: Elif Yilmazel
authors: EY
authors: Ucar
mesh_terms: D000209:Acute-Phase Proteins / Q000032:analysis*; D000328:Adult; D000368:Aged; D002570:Ceruloplasmin / Q000032:analysis; D005260:Female; D005293:Ferritins / Q000097:blood; D006801:Humans; D008175:Lung Neoplasms / Q000097:blood* / Q000150:complications; D008206:Lymphatic Diseases / Q000097:blood / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009961:Orosomucoid / Q000032:analysis; D012709:Serum Albumin / Q000032:analysis; D018709:Statistics, Nonparametric; D014168:Transferrin / Q000032:analysis
chemical_list: D000209:Acute-Phase Proteins; D009961:Orosomucoid; D012709:Serum Albumin; D014168:Transferrin; D005293:Ferritins; D002570:Ceruloplasmin