Effects of minimally invasive puncture and drainage of intracranial hematoma on the blood-brain barrier in patients with cerebral hemorrhage.
The effects of minimally invasive surgery on the blood-brain barrier (BBB) of 30 patients with cerebral hemorrhage were investigated. Difference of the BBB index and serum MBP concentration were assessed in 15 cases of conservative treatment group and 15 cases of minimally invasive surgery group. The BBB index in minimally invasive surgery group was significantly lower than in conservative treatment group (P<0.05), and the BBB index in the two treatment groups was significantly higher than in control group (P<0.01). Serum MBP concentration in minimally invasive surgery group was significantly lower than in conservative treatment group (P<0.05), and that in the two treatment groups was significantly higher than in control group (P<0.01). It was suggested the permeability of BBB in patients with cerebral hemorrhage was increased, and BBB index and serum MBP concentration in patients with cerebral hemorrhage were increased. Minimally invasive surgery can reduce the lesion of cytotoxicity to BBB and cerebral edema.
Huang
Xiaojiang
X
Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. huangxiaojiang@sina.com
Guo
Shougang
S
Wang
Wei
W
D000368:Aged; D000418:Albumins / Q000032:analysis / Q000134:cerebrospinal fluid; D001738:Biuret Reaction / Q000379:methods; D001812:Blood-Brain Barrier / Q000187:drug effects / Q000473:pathology* / Q000601:surgery*; D001961:Bromcresol Green / Q000378:metabolism; D016022:Case-Control Studies; D004322:Drainage / Q000379:methods; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006406:Hematoma / Q000000981:diagnostic imaging / Q000209:etiology* / Q000601:surgery; D006801:Humans; D007202:Indicators and Reagents / Q000378:metabolism; D020300:Intracranial Hemorrhages / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D004676:Myelin Basic Protein / Q000097:blood; D011859:Radiography; D013129:Spinal Puncture / Q000379:methods; D016896:Treatment Outcome; D014568:Urokinase-Type Plasminogen Activator / Q000627:therapeutic use
D000418:Albumins; D007202:Indicators and Reagents; D004676:Myelin Basic Protein; D001961:Bromcresol Green; D014568:Urokinase-Type Plasminogen Activator