Surrogacy theory and models of convoluted organic systems.
The theory of surrogacy is briefly outlined as one of the conceptual foundations of systems biology that has been developed for the last 30 years in the context of Hertz-Rosen modeling relationship. Conceptual foundations of modeling convoluted (biologically complex) systems are briefly reviewed and discussed in terms of current and future research in systems biology. New as well as older results that pertain to the concepts of modeling relationship, sequence of surrogacies, cascade of representations, complementarity, analogy, metaphor, and epistemic time are presented together with a classification of models in a cascade. Examples of anticipated future applications of surrogacy theory in life sciences are briefly discussed.
Konopka
Andrzej K
AK
BioLingua Research Inc, Gaithersburg, MD 20886, USA. akk@blingua.org
D006801:Humans; D008433:Mathematics; D008962:Models, Theoretical; D049490:Systems Biology