Neutral endopeptidase inhibitors and endothelin antagonists: why did the clinical trials not demonstrate beneficial effects?
Iyengar
Srinivas
S
Ohio State University, Columbus, OH 43210-1252, USA. iyengar-1@medctr.osu.edu
Abraham
William T
WT
D000818:Animals; D002986:Clinical Trials as Topic; D016232:Endothelins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D006333:Heart Failure / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D015260:Neprilysin / Q000037:antagonists & inhibitors* / Q000378:metabolism; D016896:Treatment Outcome
D016232:Endothelins; D015260:Neprilysin