Monoclonal gammopathy of undetermined significance and smoldering multiple myeloma.
Monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM) are asymptomatic disorders characterized by monoclonal plasma cell proliferation in the bone marrow in the absence of end-organ damage. Updated diagnostic criteria for these disorders, risk-stratification models to determine prognosis, and the current management of these two entities are discussed in this review.
Rajkumar
S Vincent
SV
Division of Hematology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, United States. rajkumar.vincent@mayo.edu
Lacy
Martha Q
MQ
Kyle
Robert A
RA
D018450:Disease Progression; D006801:Humans; D009101:Multiple Myeloma / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology; D009389:Neovascularization, Pathologic; D010265:Paraproteinemias / Q000097:blood / Q000175:diagnosis / Q000276:immunology / Q000503:physiopathology; D011379:Prognosis; D012307:Risk Factors