Effect of pentobarbital on pH and electrolyte levels after induced seizure in rats.
We studied the effects of high doses of pentobarbital (PB) and carbamazepine (CBZ) on electrolyte levels and pH in an epileptic animal model. Pentobarbital decreased Ca2+ and Na+ levels without pentylenetetrazole (PTZ). After this, Ca2+ and Na+ levels continued to decrease except when CBZ was used, which preserved the Ca2+ levels PTZ may have opposed effects on PB. Our results suggest that PB causes changes in electrolyte levels and pH, but these changes are diminished by CBZ.
Uribe-Escamilla
R
R
Laboratory of Neurochemistry, National Institute of Rehabilitation, SSA, México City, Mexico.
Mota-Rojas
D
D
Sánchez-Aparicio
P
P
Alonso-Spilsbury
M
M
González-Piña
R
R
Alfaro-Rodríguez
A
A
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology / Q000627:therapeutic use; D002118:Calcium / Q000378:metabolism; D002220:Carbamazepine / Q000494:pharmacology / Q000627:therapeutic use; D004195:Disease Models, Animal; D004347:Drug Interactions; D004573:Electrolytes / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration / Q000187:drug effects*; D006993:Hypnotics and Sedatives / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D010424:Pentobarbital / Q000494:pharmacology* / Q000627:therapeutic use; D010433:Pentylenetetrazole; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy / Q000378:metabolism*; D012964:Sodium / Q000378:metabolism; D018709:Statistics, Nonparametric
D000927:Anticonvulsants; D004573:Electrolytes; D006993:Hypnotics and Sedatives; D002220:Carbamazepine; D012964:Sodium; D010424:Pentobarbital; D002118:Calcium; D010433:Pentylenetetrazole