Gastrointestinal disorders in anaphylaxis.
We report two rare cases complicated by gastrointestinal mucosal disorders, including peptic ulcer and ischemic colitis. Anaphylaxis was induced by cefaclor in case 1 and by pranoprofen in case 2. These two patients developed epigastric or lower abdominal pain about 10 hours after the onset of anaphylaxis. Gastroduodenoscopy revealed severe ulcers in the stomach or duodenum, while colonoscopy detected mucosal edema, erythema, and erosions, leading to the diagnosis of ischemic colitis. It is important to keep in mind that gastrointestinal mucosal lesions can occur, albeit on rare occasions, in patients with anaphylaxis.
Shirai
Toshihiro
T
Department of Respiratory Medicine, Shizuoka General Hospital. tmjkshi@general-hosp.pref.shizuoka.jp
Mori
Masashi
M
Uotani
Takahiro
T
Chida
Kingo
K
D000328:Adult; D000368:Aged; D000707:Anaphylaxis / Q000139:chemically induced / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D000900:Anti-Bacterial Agents / Q000009:adverse effects; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects; D001578:Benzopyrans / Q000009:adverse effects; D002433:Cefaclor / Q000009:adverse effects; D017091:Colitis, Ischemic / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D004342:Drug Hypersensitivity / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D006801:Humans; D008297:Male; D011422:Propionates / Q000009:adverse effects; D013276:Stomach Ulcer / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D016896:Treatment Outcome
D000900:Anti-Bacterial Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001578:Benzopyrans; D011422:Propionates; C043940:pyranoprofen; D002433:Cefaclor