Enantioselective organocatalytic double Michael addition reactions.
[reaction: see text] A novel organocatalytic, enantioselective domino double Michael addition reaction of alpha,beta-unsaturated aldehydes with ethyl 4-mercapto-2-butenoate has been developed. The process is promoted by chiral diphenylprolinol TMS ether to give chiral tetrahydrothiophenes in high to excellent levels of enantioselectivities.
Li
Hao
H
Department of Chemistry and Chemical Biology, University of New Mexico, Albuquerque, New Mexico 87131-0001, USA.
Zu
Liansuo
L
Xie
Hexin
H
Wang
Jian
J
Jiang
Wei
W
Wang
Wei
W