Improving dementia assessment by reducing sample heterogeneity.
Outcome assessment for clinical dementia trials could be enhanced by using the Mini-mental State Examination (MMSE) and the Hopkins Verbal Learning Test (HVLT), in addition to imaging and genetic screening. The statistical power of trials could be increased if heterogeneity of the sample were reduced by the administration of a risk factor inventory which could be used for subject selection or selection of drug responders.
Folstein
Marshal
M
Tufts University School of Medicine, Boston, Massachusetts, USA. mfolstein@rcn.com
D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis / Q000523:psychology / Q000628:therapy*; D002986:Clinical Trials as Topic; D015577:Geriatric Assessment; D006801:Humans; D008609:Mental Status Schedule; D009483:Neuropsychological Tests; D017063:Outcome Assessment, Health Care; D012307:Risk Factors