title: Hepatic stellate cell damage may lead to decreased plasma ADAMTS13 activity in rats.
abstract: ADAMTS13 is gaining attention, because its deficiency causes thrombotic thrombocytopenic purpura. Although its regulatory mechanism is not fully understood, we wondered if hepatic stellate cells (HSCs) play a role, because ADAMTS13 mRNA is exclusively expressed in the liver and primarily in HSCs. Plasma ADAMTS13 activity was markedly reduced in dimethylnitrosamine-treated rats, where HSC apoptosis is an essential event, but not in carbon tetrachloride- or thioacetamide-treated rats without HSC apoptosis. Furthermore, plasma ADAMTS13 activity was also reduced in 70% hepatectomized rats, where HSC loss occurs. These results suggest that HSC may be involved in the regulation of plasma ADAMTS13 activity.
authors: Department of Laboratory Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.
authors: Yukio
authors: Y
authors: Kume
authors: Hitoshi
authors: H
authors: Ikeda
authors: Morihiro
authors: M
authors: Inoue
authors: Kazuaki
authors: K
authors: Tejima
authors: Tomoaki
authors: T
authors: Tomiya
authors: Takako
authors: T
authors: Nishikawa
authors: Naoko
authors: N
authors: Watanabe
authors: Tatsuya
authors: T
authors: Ichikawa
authors: Makoto
authors: M
authors: Kaneko
authors: Shigeo
authors: S
authors: Okubo
authors: Hiromitsu
authors: H
authors: Yokota
authors: Masao
authors: M
authors: Omata
authors: Kenji
authors: K
authors: Fujiwara
authors: Yutaka
authors: Y
authors: Yatomi
mesh_terms: D051722:ADAM Proteins / Q000097:blood*; D000071120:ADAMTS13 Protein; D000818:Animals; D017209:Apoptosis; D004128:Dimethylnitrosamine / Q000633:toxicity; D008099:Liver / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D051722:ADAM Proteins; D000071120:ADAMTS13 Protein; C512067:Adamts13 protein, rat; D004128:Dimethylnitrosamine