Neurogenesis and major depression: implications from proteomic analyses of hippocampal proteins in a rat depression model.
Major depression is one of the most disabling disorders. Yet, the pathogenesis of this mental disorder is poorly understood. Hippocampus is generally believed to be associated with pathogenesis of depression. In this study, we adopted a proteomic approach to examine possible alterations of protein expression in the hippocampus of a rat depression model. Our results suggest that neurogenesis in hippocampus may play an important role in the pathogenesis of major depression.
Mu
Jun
J
Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, The Key Laboratory of Diagnostic Medicine Designated by the Ministry of Education, Chongqing 400016, China.
Xie
Peng
P
Yang
Ze-Song
ZS
Yang
De-Lan
DL
Lv
Fa-Jin
FJ
Luo
Tian-You
TY
Li
Yong
Y
D000818:Animals; D003863:Depression / Q000473:pathology*; D004195:Disease Models, Animal; D015180:Electrophoresis, Gel, Two-Dimensional / Q000379:methods; D005786:Gene Expression Regulation / Q000502:physiology*; D006624:Hippocampus / Q000378:metabolism* / Q000503:physiopathology*; D007525:Isoelectric Focusing / Q000379:methods; D008297:Male; D009474:Neurons / Q000502:physiology*; D038081:Organogenesis; D040901:Proteomics / Q000379:methods; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors