title: Comparison of liver histopathology between chronic hepatitis C patients and chronic hepatitis B and C-coinfected patients.
abstract: BACKGROUND
  The aim of the present study was to compare the histological characteristics of livers between chronic hepatitis C (CHC) patients with and without hepatitis B virus (HBV) coinfection.
  
  
  METHODS
  A total of 336 CHC patients (male/female: 204/132, mean age: 46.1 +/- 11.7 years) were enrolled in the study; 32 patients (9.8%) were positive for hepatitis B surface antigen (HBsAg). The histological characteristics of livers were described according to the Knodell and Scheuer scoring system.
  
  
  RESULTS
  The proportion of non-intralobular necrosis (score 0) was significantly lower and the mean intralobular necrosis score was higher among CHC patients with HBV coinfection than those without coinfection (43.8% vs 64.5%; 0.84 +/- 1.05 vs 0.53 +/- 0.89). The epidemiological and virological parameters, and other histological scores (periportal necrosis, portal inflammation, total necroinflammation and fibrosis) were not significantly different between these two groups.
  
  
  CONCLUSIONS
  Chronic hepatitis C patients with HBV coinfection tend to have more severe intralobular necrosis than those with isolated HCV infection.
authors: Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Chung-Ho Memorial Hospital, Taiwan.
authors: Li-Po
authors: LP
authors: Lee
authors: Chia-Yen
authors: CY
authors: Dai
authors: Wan-Long
authors: WL
authors: Chuang
authors: Wen-Yu
authors: WY
authors: Chang
authors: Nei-Jen
authors: NJ
authors: Hou
authors: Ming-Yen
authors: MY
authors: Hsieh
authors: Zu-Yau
authors: ZY
authors: Lin
authors: Shinn-Cherng
authors: SC
authors: Chen
authors: Ming-Yuh
authors: MY
authors: Hsieh
authors: Liang-Yen
authors: LY
authors: Wang
authors: Tong-Jong
authors: TJ
authors: Chen
authors: Ming-Lung
authors: ML
authors: Yu
mesh_terms: D000328:Adult; D005260:Female; D016174:Hepacivirus / Q000502:physiology; D006514:Hepatitis B Surface Antigens / Q000032:analysis; D006515:Hepatitis B virus / Q000502:physiology; D019694:Hepatitis B, Chronic / Q000150:complications / Q000473:pathology*; D019698:Hepatitis C, Chronic / Q000150:complications / Q000473:pathology*; D006801:Humans; D008099:Liver / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009336:Necrosis / Q000473:pathology; D014762:Viral Interference
chemical_list: D006514:Hepatitis B Surface Antigens