title: Emerging functions of extracellular pyridine nucleotides.
abstract: In addition to the well-known metabolic functions of NAD and NADP, it is rapidly emerging that these 2 pyridine nucleotides and their derivatives also play important roles in cell signaling. Surprisingly, a number of NAD(P) metabolizing enzymes and NAD(P) targets have been found on the outer surface of the plasma membrane and the presence of NAD has been confirmed in extracellular fluids. These findings have opened the door to a new field of research aimed at elucidating the contribution of extracellular pyridine nucleotides in physiological signaling pathways and pathological conditions.
authors: DiSCAFF and the DFB Centre, Università del Piemonte Orientale, Via Bovio 6, 28100 Novara, Italy.
authors: Richard A
authors: RA
authors: Billington
authors: Santina
authors: S
authors: Bruzzone
authors: Antonio
authors: A
authors: De Flora
authors: Armando A
authors: AA
authors: Genazzani
authors: Friedrich
authors: F
authors: Koch-Nolte
authors: Mathias
authors: M
authors: Ziegler
authors: Elena
authors: E
authors: Zocchi
mesh_terms: D000818:Animals; D045604:Extracellular Fluid / Q000502:physiology; D006706:Homeostasis; D006801:Humans; D008322:Mammals; D009243:NAD / Q000502:physiology*; D009249:NADP / Q000502:physiology*; D015398:Signal Transduction
chemical_list: D009243:NAD; D009249:NADP