Enantioselective desymmetrization of prochiral cyclohexanone derivatives via the organocatalytic direct Aldol reaction.
Asymmetric desymmetrization of 4-substituted cyclohexanones using proline amide-catalyzed direct aldol reaction afforded beta-hydroxyketones with three stereogenic centers in high enantioselectivities of up to >99% ee.
Jiang
Jun
J
Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu, 610041, China.
He
Long
L
Luo
Shi-Wei
SW
Cun
Lin-Feng
LF
Gong
Liu-Zhu
LZ