Central giant cell granuloma associated with central ossifying fibroma of the jaws: a clinicopathologic study.
OBJECTIVE
To investigate the prevalence of clinical, radiographic, and histopathologic characteristics of combined central giant cell granuloma (CGCG) and central ossifying fibroma (COF).


METHODS
Retrospective clinical and histomorphometric analysis of all cases diagnosed as CGCG or COF between 1994 and 2002.


RESULTS
A total of 51 cases were included in the study: CGCG (n = 23), COF (n = 25), and combined COF-CGCG (n = 3). All 3 lesions presented expansile, well-defined unilocular radiolucencies, with radiopacities (66%), root resorption (66%) and tooth displacement (33%). Microscopically, areas of classical CGCG and COF were separated by a transition zone of nonvascularized densely packed spindle cells. Surgical procedure resulted in recurrence within 1 year in 1 of 2 patients, calcitonin nasal spray treatment resulted in growth arrest in 1 case.


CONCLUSIONS
Because of the small number of the combined cases, the biologic behavior of the lesions is uncertain. The CGCG component may drive the clinical behavior toward a more aggressive behavior than classical COF; therefore, close follow-up is recommended.
Kaplan
Ilana
I
Pathology Service, Rabin Medical Center, Beilinson Campus.
Manor
Ifat
I
Yahalom
Ran
R
Hirshberg
Abraham
A
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D005260:Female; D018214:Fibroma, Ossifying / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology; D006101:Granuloma, Giant Cell / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D007571:Jaw Diseases / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology; D007573:Jaw Neoplasms / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011859:Radiography; D012189:Retrospective Studies