title: Structural biology of RNA silencing and its functional implications.
abstract: We outline structure-function contributions from our laboratories on protein-RNA recognition events that monitor siRNA length, 5 -phosphate and 2-nucleotide 3 overhangs, as well as the architecture of Argonaute, its externally bound siRNA complex, and Argonaute-based models involving guide-strand-mediated mRNA binding, cleavage, and release.
authors: Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.
authors: D J
authors: DJ
authors: Patel
authors: J-B
authors: JB
authors: Ma
authors: Y-R
authors: YR
authors: Yuan
authors: K
authors: K
authors: Ye
authors: Y
authors: Y
authors: Pei
authors: V
authors: V
authors: Kuryavyi
authors: L
authors: L
authors: Malinina
authors: G
authors: G
authors: Meister
authors: T
authors: T
authors: Tuschl
mesh_terms: D001426:Bacterial Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D006801:Humans; D035683:MicroRNAs / Q000096:biosynthesis; D008954:Models, Biological; D008958:Models, Molecular; D010448:Peptide Initiation Factors / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D017434:Protein Structure, Tertiary; D034622:RNA Interference; D012333:RNA, Messenger / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D034741:RNA, Small Interfering / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D043244:Ribonuclease III / Q000378:metabolism; D014764:Viral Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism
chemical_list: D001426:Bacterial Proteins; D035683:MicroRNAs; D010448:Peptide Initiation Factors; D012333:RNA, Messenger; D034741:RNA, Small Interfering; D014764:Viral Proteins; D043244:Ribonuclease III