title: Nonfluent aphasia in a patient with Waldenstrom's macroglobulinemia.
abstract: Waldenstrom's macroglobulinemia (WM) is an uncommon low-grade lymphoma. Cognitive impairment due to central nervous system infiltration by lymphoplasmocytoid cells (Bing-Neel syndrome) has been rarely reported. We describe a 54-year-old man who was referred to a memory disorder clinic with a 9-month history of clinically obvious nonfluent aphasia and WM. He underwent extensive neuropsychological testing, clinical examination and structural and functional brain imaging. The diagnosis of the diffuse form of the Bing-Neel syndrome was supported by abnormal lymphoid cells found in the cerebrospinal fluid. Structural and functional brain imaging revealed impairment of brain areas due to white matter changes and subsequent functional deficits mimicking the neuropsychological syndrome encountered in progressive nonfluent aphasia. The diffuse form of Bing-Neel syndrome and neurological deficits are assumed to be the result of leptomeningeal infiltration by malignant cells and/or neoplastic vascular obstruction.
authors: Department of Psychiatry and Psychotherapy, University of Technology, Fetscherstrasse 74, 01307 Dresden, Germany. markus.donix@uniklinikum-dresden.de
authors: Markus
authors: M
authors: Donix
authors: Bettina
authors: B
authors: Beuthien-Baumann
authors: Rüdiger
authors: R
authors: von Kummer
authors: Georg
authors: G
authors: Gahn
authors: Fatima
authors: F
authors: Thomas
authors: Vjera
authors: V
authors: Holthoff
mesh_terms: D001039:Aphasia, Broca / Q000209:etiology* / Q000473:pathology; D001921:Brain / Q000473:pathology; D002493:Central Nervous System Diseases / Q000209:etiology* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D008258:Waldenstrom Macroglobulinemia / Q000150:complications* / Q000473:pathology