[Von Willebrand factor activity in patients with systemic lupus erythematosus].
Eighty four SLE patients have been studied. The levels of Willebrand factor, total antibodies to cardiolipin class IgG, antibodies to D-DNA, total index of inflammatory process activity SLEDAI and other routine markers have been assessed. Endothelial-dependent vasodilatation of brachial artery and carotid intima-media thickness was found to exceed that of control group twice as much. The elevation of Willebrand factor is associated with increase in SLE activity and correlated with SLEDAI index, C-reactive protein level and total antibody content to IgG class phospholipids. The elevation of Willebrand factor activity is also associated with endothelial-dependent vasodilatation impairment in patients with high inflammatory process activity in particular.
Shevchuk
S V
SV
D000328:Adult; D016736:Antiphospholipid Syndrome / Q000097:blood / Q000276:immunology; D001323:Autoantibodies / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D002308:Cardiolipins / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology; D008180:Lupus Erythematosus, Systemic / Q000097:blood* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D014841:von Willebrand Factor / Q000032:analysis* / Q000276:immunology
D001323:Autoantibodies; D002308:Cardiolipins; D007074:Immunoglobulin G; D014841:von Willebrand Factor; D002097:C-Reactive Protein