Microwave-assisted RCM for the synthesis of carbocyclic peptides.
Microwave irradiation dramatically improves the efficiency of ring closing metathesis (RCM) reactions of resin-attached peptides and the technology is illustrated by the highly selective synthesis of dicarba analogues of alpha-conotoxin IMI.
Robinson
Andrea J
AJ
School of Chemistry, Monash University, Clayton 3800, Victoria, Australia. andrea.robinson@sci.monash.edu.au
Elaridi
Jomana
J
Van Lierop
Bianca J
BJ
Mujcinovic
Selma
S
Jackson
W Roy
WR
D000146:Acids, Carbocyclic / Q000737:chemistry; D001671:Biochemistry / Q000379:methods*; D008872:Microwaves; D010455:Peptides / Q000138:chemical synthesis*
D000146:Acids, Carbocyclic; D010455:Peptides