title: An unusual reciprocal X-autosome translocation in an infertile azoospermic man.
abstract: OBJECTIVE
  To analyze an unusual reciprocal X-autosome translocation found in an infertile man with azoospermia.
  
  
  METHODS
  Case report with a review of scientific literature.
  
  
  METHODS
  Male infertility clinic, Kobe University Hospital.
  
  
  METHODS
  Infertile man with azoospermia but otherwise apparently healthy.
  
  
  METHODS
  Peripheral blood lymphocytes were obtained for karyotyping, and metaphases were studied by fluorescence in situ hybridization procedure.
  
  
  METHODS
  Seminal analysis, hormone levels, volume of testis, and pathologic analysis of testis were performed.
  
  
  RESULTS
  The semen analysis revealed azoospermia. The lymphocytic karyotype showed a man with X-autosome translocations. Histopathologic examination of the sample showed maturation arrest.
  
  
  CONCLUSIONS
  This is the first clinical report of azoospermia with reciprocal X-autosome 11 translocations. This translocation may be a direct genetic risk factor for maturation arrest.
authors: Division of Urology, Department of Organs Therapeutics, Faculty of Medicine, Kobe University Graduate School of Medicine, Kobe, Japan. iskwtmmt@med.kobe-u.ac.jp <iskwtmmt@med.kobe-u.ac.jp>
authors: Tomomoto
authors: T
authors: Ishikawa
authors: Yutaka
authors: Y
authors: Kondo
authors: Kohei
authors: K
authors: Yamaguchi
authors: Takeshi
authors: T
authors: Oba
authors: Yuichi
authors: Y
authors: Sakamoto
authors: Atsushi
authors: A
authors: Takenaka
authors: Masato
authors: M
authors: Fujisawa
mesh_terms: D053713:Azoospermia / Q000235:genetics*; D041321:Chromosomes, Human, X; D006801:Humans; D007248:Infertility, Male / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D014176:Protein Biosynthesis; D012729:Sex Chromosome Aberrations