Myasthenia and neuroborreliosis with excessively high acetylcholine-receptor antibodies.
In a 29-y-old male with neuroborreliosis, partially responsive to ceftriaxone, myasthenia gravis with acetylcholine-receptor antibodies elevated almost 1000 times the upper reference limit was diagnosed. Pyridostigmine resolved all remaining neurological deficits. During a 1-y follow-up the patient remained symptom free, despite persistently high acetylcholine-receptor antibodies. They were attributed to epitope homology of the acetylcholine receptors and Borrelia surface antigens.
Finsterer
Josef
J
Krankenanstalt Rudolfstiftung, Vienna, Austria. duarte@aonmail.at
D000328:Adult; D001323:Autoantibodies / Q000276:immunology*; D006801:Humans; D020852:Lyme Neuroborreliosis / Q000175:diagnosis*; D008297:Male; D009157:Myasthenia Gravis / Q000175:diagnosis* / Q000276:immunology; D011950:Receptors, Cholinergic / Q000276:immunology*
D001323:Autoantibodies; D011950:Receptors, Cholinergic