[Massive rhabdomyolysis revealing a McArdle disease].
BACKGROUND
McArdle's disease is an autosomal recessive glycogenosis caused by deficiency of muscle glycogen phosphorylase resulting in glycogen accumulation in the skeletal muscle. Typically, McArdle's disease is characterized by exercise intolerance with muscle cramps and myoglobinuria.


METHODS
We report a 20-year-old woman with massive rhabdomyolysis and acute renal failure revealing a McArdle's disease.


CONCLUSIONS
Although muscle impairment is constant in McArdle's disease, massive rhabdomyolysis with severe acute renal failure has been rarely reported as a presenting feature. The mechanisms and therapeutic implications of renal injury are discussed.
Loupy
A
A
Service des Urgences Néphrologiques et Transplantation Rénale, Hôpital Tenon, 4, rue de la Chine, 75020 Paris, France. alexandreloupy@gmail.com
Pouchot
J
J
Hertig
A
A
Bonnard
G
G
Bouvard
E
E
Rondeau
E
E
D058186:Acute Kidney Injury / Q000209:etiology; D000328:Adult; D005260:Female; D005919:Glomerular Filtration Rate; D006012:Glycogen Storage Disease Type V / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D006801:Humans; D012206:Rhabdomyolysis / Q000209:etiology*