title: Association between inadequate sleep and insulin resistance in obese children.
abstract: OBJECTIVE
  To analyze the relationships between sleep duration, obstructive sleep apnea syndrome (OSAS), and markers of insulin resistance in obese children.
  
  
  METHODS
  Forty obese children were evaluated for sleep-related complaints. Each child underwent a polysomnogram, an oral glucose tolerance test (OGTT), and fasting lipid panel tests. Indices of insulin resistance (HOMA-IR and WBISI) and insulin secretion (IGI) were calculated based on the results of the OGTT. Markers of insulin resistance were compared among groups categorized according to polysomnogram results.
  
  
  RESULTS
  Subjects with shorter sleep duration had higher fasting insulin, peak insulin, and HOMA-IR levels and lower WBISI levels, findings suggestive of insulin resistance. In contrast, differences in body mass index z scores were not observed. Subjects with OSAS (32 of 40 children) had higher triglyceride levels and HOMA-IR values than those without OSAS, but did not differ in sleep duration. Multiple linear regression analysis revealed that HOMA-IR was significantly correlated with age, sleep duration, and percentage of rapid-eye-movement sleep.
  
  
  CONCLUSIONS
  Insulin resistance in obese children is associated with short sleep duration and OSAS.
authors: Section of Endocrinology, St Christopher's Hospital for Children, Philadelphia, Pennsylvania 19134, USA. janna.flint@tenethealth.com
authors: Janna
authors: J
authors: Flint
authors: Sanjeev V
authors: SV
authors: Kothare
authors: Mamoon
authors: M
authors: Zihlif
authors: Elizabeth
authors: E
authors: Suarez
authors: Ruth
authors: R
authors: Adams
authors: Agustin
authors: A
authors: Legido
authors: Francesco
authors: F
authors: De Luca
mesh_terms: D000293:Adolescent; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose; D015984:Causality; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D015897:Comorbidity; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D016014:Linear Models; D008297:Male; D009765:Obesity / Q000097:blood / Q000453:epidemiology*; D015143:Philadelphia / Q000453:epidemiology; D012307:Risk Factors; D020181:Sleep Apnea, Obstructive / Q000453:epidemiology*; D013997:Time Factors
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D007328:Insulin