title: Long-term changes in sleep and depressive symptoms of smokers in abstinence.
abstract: Few studies have evaluated the impact of smoking cessation on objective measures of sleep. The present study assessed the long-term effects of tobacco smoking abstinence on sleep and depression. A total of 15 chronic smokers with Hamilton Rating Scale for Depression (HAM-D) scores of less than 9 were evaluated. Subjects were screened for baseline data when they were smoking chronically. They underwent a 5-week psychological treatment for tobacco smoking, after which their depressive symptoms and sleep architecture were evaluated at 1, 2, 4, 6, 9, and 12 months of abstinence. We report the results of the seven patients who completed 1 year of evaluations and of those patients who achieved only partial abstinence. Polysomnographic recordings were taken, level of depression was measured with the HAM-D, and urinary cotinine levels also were evaluated. HAM-D scores were analyzed with and without sleep items. Nicotine abstinence reduced latency to rapid eye movement (REM) sleep and increased HAM-D scores, suggesting that chronic smokers have depressive symptoms that may be controlled by nicotine administration.
authors: Depto. de Neurociencias, Instituto de Fisiología Celular y Clínica de Trastornos del Sueño, Universidad Nacional Autónoma de México, México.
authors: Ana
authors: A
authors: Moreno-Coutiño
authors: Carmen
authors: C
authors: Calderón-Ezquerro
authors: René
authors: R
authors: Drucker-Colín
mesh_terms: D000328:Adult; D003367:Cotinine / Q000652:urine; D003863:Depression / Q000175:diagnosis* / Q000188:drug therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016015:Logistic Models; D008137:Longitudinal Studies; D008297:Male; D008800:Mexico; D008875:Middle Aged; D009538:Nicotine / Q000008:administration & dosage; D017286:Polysomnography / Q000379:methods; D007319:Sleep Initiation and Maintenance Disorders / Q000175:diagnosis* / Q000188:drug therapy; D012895:Sleep, REM / Q000187:drug effects; D016540:Smoking Cessation; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy / Q000503:physiopathology*; D011795:Surveys and Questionnaires; D014029:Tobacco Use Disorder / Q000188:drug therapy / Q000503:physiopathology*
chemical_list: D009538:Nicotine; D003367:Cotinine