[Study of prophylactic intra-iliac and hepatic arterial infusion chemotherapy against pelvic recurrence and liver metastasis after radical resection for rectal cancer].
OBJECTIVE
To study the effects of prophylactic intra-iliac and hepatic arterial infusion chemotherapy on pelvic recurrence and liver metastasis after radical resection for rectal cancer.


METHODS
Eighty-four rectal cancer patients,undergone radical resection on Dukes stage B or C,were randomly assigned to postoperative intra-iliac and hepatic arterial infusion chemotherapy group(group I) and routine vein chemotherapy group(group II). Five-year survival and recurrence rates were compared between the two groups.


RESULTS
Among the 84 rectal cancer patients with radical resection, the 5-year liver metastasis and pelvic recurrence rates were 30.2% (13/43) and 18.6% (8/43) respectively in group II, 17.1% (7/41) and 9.8% (4/41) in group I, the difference was significant between 2 groups (chi(2)=4.31, P<0.05). The mean tumor-free survival time was 26.2 months in group I and 15.8 months in group II (t=5.05, P<0.01), the difference was significant (t=5.05, P<0.01). The five-year survival rate in group I (65.9%) was significantly higher than that in group II (56.5%) (u=8.86, P<0.01). Cox multivariate analysis showed that, compared with those in group II, the relative risks of pelvic recurrence and liver metastasis in group I decreased 20% (coefficient of relative risk: 0.7959), and the five-year mortality also decreased 20% (coefficient of relative risk: 0.8034).


CONCLUSIONS
Prophylactic intra-iliac and hepatic arterial infusion chemotherapy can reduce the rates of pelvic recurrence and liver metastasis after radical resection of rectal cancer.
Tu
Shi-liang
SL
Department of General Surgery, Zhejiang Provincial Peopleçs Hospital, Hangzhou 310014, China. tushiliang@126.com
Yuan
Jian-hua
JH
Deng
Gao-li
GL
Zhao
Zhong-sheng
ZS
Hu
Ting-yang
TY
Dong
Quan-jin
QJ
Cao
Hong-feng
HF
Ye
Zai-yuan
ZY
D000328:Adult; D017024:Chemotherapy, Adjuvant; D010478:Chemotherapy, Cancer, Regional Perfusion; D005260:Female; D006499:Hepatic Artery; D006801:Humans; D007083:Iliac Artery; D008113:Liver Neoplasms / Q000517:prevention & control / Q000556:secondary; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control; D010386:Pelvic Neoplasms / Q000517:prevention & control / Q000556:secondary; D010388:Pelvis / Q000473:pathology; D012004:Rectal Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D015996:Survival Rate