Effect of gamma rays on the bone repair process in rats with estrogen deficiency.
This study aimed at evaluating the bone repair process in ovariectomized rats submitted to an irradiation procedure. For this purpose, one hundred rats were randomly divided in four experimental groups: control, ovariectomized, irradiated and irradiated/ovariectomized. A bone defect was made on all animals' tibias. Three days after surgery, only irradiated and irradiated/ovariectomized rats received 8 Gy of gamma rays on the lower limbs region. The animals were sacrificed 7, 14, 21 and 28 days after surgery in order to assess the repair process. It was possible to observe a delay in the bone repair process in the irradiated/ovariectomized group, in which there was a remarkable association between estrogen deficiency and ionizing radiation resulting in the reduction of newly formed bone production, thus accelerating the resorption process.
Chicarelli
Mariliani
M
School of Dentistry, State University of Campinas, Faculty of Odontology of Piracicaba, Oral Radiology, Av. Limeira 901, Piracicaba, SP, Brazil, CEP 13414-018.
Ramos
Flávia Maria de Moraes
FM
Manzi
Flávio Ricardo
FR
Novaes
Pedro Duarte
PD
Bóscolo
Frab Norberto
FN
Almeida
Solange Maria de
SM
D000818:Animals; D015519:Bone Density / Q000502:physiology; D001842:Bone and Bones / Q000502:physiology / Q000528:radiation effects*; D004195:Disease Models, Animal; D004967:Estrogens / Q000172:deficiency*; D005260:Female; D017102:Fracture Healing / Q000528:radiation effects*; D005720:Gamma Rays / Q000009:adverse effects; D010024:Osteoporosis / Q000209:etiology; D010052:Ovariectomy; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
D004967:Estrogens