title: A new hypothesis on the role of c-erbB2 oncogene in the progress of breast cancer.
abstract: Proliferation and the state of adhesion molecules (E-cadherin, galectin-3) and estrogen and progesterone receptors were immunohistochemically analyzed in breast cancer biopsy specimens under conditions of c-erbB2 overexpression with and without gene amplification. It was hypothesized that c-erbB2 overexpression without gene amplification led to suppression of proliferation and "conservation" of tumor cell.
authors: Clinical Oncological Center, Ministry of Health of Republic of Tatarstan, Kazan. semyonp@mail.ru
authors: S V
authors: SV
authors: Petrov
authors: G A
authors: GA
authors: Raskin
authors: R Sh
authors: RSh
authors: Khasanov
mesh_terms: D001706:Biopsy; D001943:Breast Neoplasms / Q000235:genetics* / Q000378:metabolism*; D015820:Cadherins / Q000378:metabolism; D050759:Cyclin-Dependent Kinase Inhibitor p21 / Q000378:metabolism; D018450:Disease Progression; D005260:Female; D037502:Galectin 3 / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000235:genetics / Q000378:metabolism*; D011960:Receptors, Estrogen / Q000378:metabolism; D011980:Receptors, Progesterone / Q000378:metabolism
chemical_list: D015820:Cadherins; D050759:Cyclin-Dependent Kinase Inhibitor p21; D037502:Galectin 3; D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone