Soluble tumor necrosis factor receptor 2 is independently associated with pulse wave velocity in nonobese Japanese patients with type 2 diabetes mellitus.
The aim of the present study was to investigate the factors contributing to pulse wave velocity (PWV) in patients with type 2 diabetes mellitus. We focused on tumor necrosis factor (TNF) including soluble TNF receptors (sTNF-R1, sTNF-R2) in this study because TNF seems to be associated with the progression of atherosclerosis and because the relationships between PWV and TNF were not yet examined in type 2 diabetic patients. Univariate regression analyses showed that PWV was positively correlated with age (r=0.492, P<.001), diabetes duration (r=0.251, P=.021), systolic (r=.595, P<.001) and diastolic (r=0.248, P=.022) blood pressure, antihypertensive medication (r=0.268, P=.013), and the concentrations of sTNF-R1 (r=0.354, P=.001) and sTNF-R2 (r=0.415, P<.001). Although there was a positive correlation between TNF-alpha and sTNF-R1 (r=0.382, P<.001) or sTNF-R2 (r=0.394, P<.001), TNF-alpha was not associated with PWV. Other variables including gender were not associated with PWV. Multiple regression analyses showed that PWV was independently predicted by the level of age (F=15.1), systolic blood pressure (F=31.6), and sTNF-R2 (F=5.2), which explained 49.2% of the variability of PWV. From these results, it can be concluded that serum soluble TNF receptor is an important independent factor associated with aortic PWV in type 2 diabetic patients.
Ohgushi
Minako
M
Division of Diabetes and Clinical Nutrition, Kansai-Denryoku Hospital, Osaka 553-0003, and School of Health Sciences Faculty of Medicine, Kyoto University Graduate School of Medicine, Japan.
Taniguchi
Ataru
A
Fukushima
Mitsuo
M
Nakai
Yoshikatsu
Y
Kuroe
Akira
A
Ohya
Michihiro
M
Nagasaka
Shoichiro
S
Taki
Yoshiro
Y
Yoshii
Satoru
S
Matsumoto
Kazunari
K
Yamada
Yuichiro
Y
Inagaki
Nobuya
N
Seino
Yutaka
Y
D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000503:physiopathology*; D006801:Humans; D007333:Insulin Resistance; D007564:Japan; D008875:Middle Aged; D018124:Receptors, Tumor Necrosis Factor / Q000097:blood*
D001786:Blood Glucose; D018124:Receptors, Tumor Necrosis Factor