The effect of epidural anesthesia with different concentrations of ropivacaine on sevoflurane requirements.
BACKGROUND
We evaluated sevoflurane requirements during combined general-epidural anesthesia with different concentration of ropivacaine.


METHODS
Fifty-six patients were randomly divided into three groups to epidurally receive saline, 0.2% ropivacaine or 1% ropivacaine. Sevoflurane concentration was adjusted to maintain certain anesthesia depth. BIS values and end-tidal sevoflurane concentrations were recorded at time points of pre-intubation and 5 min, 10 min, 15 min, 20 min, 25 min, 30 min after intubation.


RESULTS
End-tidal sevoflurane was significantly lower in the group receiving higher concentration of sevoflurane.


CONCLUSIONS
Epidural anesthesia can decrease sevoflurane requirements to a larger extent when a higher concentration of ropivacaine was applied.
Zhang
Jie
J
Department of Anesthesiology, The First Affiliated Hospital of ZhengZhou University, No. 1 East-JianShe Road, ZhengZhou 450052, China. joannyzh@hotmail.com
Zhang
Wei
W
Li
Bin
B
D000005:Abdomen / Q000601:surgery; D000328:Adult; D000577:Amides / Q000008:administration & dosage*; D000767:Anesthesia, Epidural; D000768:Anesthesia, General; D019162:Anesthetics, Combined / Q000008:administration & dosage*; D018685:Anesthetics, Inhalation / Q000008:administration & dosage* / Q000493:pharmacokinetics; D000779:Anesthetics, Local / Q000008:administration & dosage*; D003243:Consciousness / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008738:Methyl Ethers / Q000008:administration & dosage* / Q000493:pharmacokinetics; D008875:Middle Aged; D011650:Pulmonary Alveoli / Q000378:metabolism; D000077212:Ropivacaine; D000077149:Sevoflurane; D012890:Sleep / Q000187:drug effects; D013997:Time Factors
D000577:Amides; D019162:Anesthetics, Combined; D018685:Anesthetics, Inhalation; D000779:Anesthetics, Local; D008738:Methyl Ethers; D000077149:Sevoflurane; D000077212:Ropivacaine