Synthesis and biological evaluation of 12 allenic aromatic ethers.
Twelve allenic aromatic ethers, some of them are natural products isolated from the mangrove fungus Xylaria sp. 2508 in the South China Sea, were synthesized. Their antitumor activities against KB and KBv200 cells were determined. All these compounds demonstrated cytotoxic potential, ranging from weak to strong activity. The analysis of structure-activity relationships suggested that the introduction of allenic moiety could generate or enhance cytotoxicity of these phenol compounds.
Wang
San-Yong
SY
School of Chemistry and Chemical Engineering, Sun Yat-Sen(Zhongshan) University, Guangzhou 510275, China.
Mao
Wei-Wei
WW
She
Zhi-Gang
ZG
Li
Chun-Rong
CR
Yang
Ding-Qiao
DQ
Lin
Yong-Cheng
YC
Fu
Li-Wu
LW
D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D002681:China; D004354:Drug Screening Assays, Antitumor; D004986:Ether / Q000737:chemistry / Q000494:pharmacology*; D004987:Ethers / Q000737:chemistry / Q000494:pharmacology; D005069:Evaluation Studies as Topic; D006801:Humans; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D004987:Ethers; D004986:Ether