Strain-dependent variation in Mycobacterium bovis BCG-induced human T-cell activation and gamma interferon production in vitro.
Three commonly used Mycobacterium bovis BCG vaccine strains elicited different magnitudes of T-cell activation and gamma interferon production in vitro in healthy BCG-vaccinated individuals. Glaxo 1077 exhibited the greatest stimulatory capacity, followed by Pasteur 1173 and then Danish 1331. These differences may affect in vitro stimulation and vaccination-induced immunogenicity.
Aguirre-Blanco
Ana M
AM
Department of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, Keppel Street, London, UK.
Lukey
Pauline T
PT
Cliff
Jacqueline M
JM
Dockrell
Hazel M
HM
D000907:Antibodies, Bacterial / Q000096:biosynthesis; D001500:BCG Vaccine / Q000276:immunology / Q000494:pharmacology*; D006801:Humans; D007371:Interferon-gamma / Q000096:biosynthesis* / Q000378:metabolism; D008213:Lymphocyte Activation / Q000187:drug effects*; D009163:Mycobacterium bovis / Q000145:classification / Q000276:immunology / Q000502:physiology*; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology / Q000502:physiology
D000907:Antibodies, Bacterial; D001500:BCG Vaccine; D007371:Interferon-gamma