Thirty-five years of synthetic studies directed towards the histrionicotoxin family of alkaloids.
This article brings together for the first time reviews of all the synthetic attempts towards the spirocyclic histrionicotoxin alkaloids published since the discovery of the group in 1971. This covers 5 total syntheses of the fully unsaturated parent alkaloid HTX-283A, 7 total syntheses of perhydrohistrionicotoxin, 15 total syntheses of other members of this alkaloid family, 25 formal syntheses, and 19 partial syntheses involving the successful formation of the core azaspirocyclic structure but lacking advancement towards the target structure.
Sinclair
Alex
A
School of Chemical Sciences and Pharmacy, University of East Anglia, Norwich, NR4 7TJ, UK.
Stockman
Robert A
RA
D000470:Alkaloids / Q000138:chemical synthesis*; D000664:Amphibian Venoms / Q000138:chemical synthesis*; D001688:Biological Products / Q000138:chemical synthesis*; D015394:Molecular Structure; D013141:Spiro Compounds / Q000138:chemical synthesis*
D000470:Alkaloids; D000664:Amphibian Venoms; D001688:Biological Products; C519470:HTX-283A; D013141:Spiro Compounds; C007948:histrionicotoxin