title: Taenia solium dUTPase: A potential target for anti-human cysticercosis.
abstract: dUTPase plays an essential role in pyrimidine metabolism in many organisms. In this study we report the dUTPase-encoding gene (Tdut) from Taenia solium oncospheres and larvae. Alignment reveals that the putative protein contains five conserved motifs that are often found in many characterized dUTPases. The deduced amino acid sequence has only 65.2% identity with human dUTPases. This low identity encourages its use for the design of new drugs against cysticercosis.
authors: Key Laboratory of Veterinary Parasitology of Gansu Province, State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, CAAS, 1 Xujiaping Road, Lanzhou, Gansu 730046, China. zhyd9@yahoo.com.cn
authors: Yadong
authors: Y
authors: Zheng
authors: Xuenong
authors: X
authors: Luo
authors: Zhenyong
authors: Z
authors: Liu
authors: Zhizhong
authors: Z
authors: Jing
authors: Wanzhong
authors: W
authors: Jia
authors: Xuepeng
authors: X
authors: Cai
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D003551:Cysticercosis / Q000188:drug therapy / Q000209:etiology; D005784:Gene Amplification; D006801:Humans; D010802:Phylogeny; D011755:Pyrophosphatases / Q000145:classification / Q000235:genetics*; D041201:Taenia solium / Q000201:enzymology* / Q000235:genetics
chemical_list: D011755:Pyrophosphatases; C020020:dUTP pyrophosphatase