title: Urticarial vasculitis secondary to paroxetine.
abstract: Paroxetine (Paxil) is a widely prescribed antidepressant of the selective serotonin reuptake inhibitor (SSRI) class for which multiple cutaneous adverse effects have been reported, including urticaria, ecchymoses, vasculitis, and pruritus. In contrast, fluoxetine (Prozac) is the only SSRI previously reported to cause urticarial vasculitis. Urticarial vasculitis is a chronic disorder marked by recurrent episodes of erythematous, indurated wheals that histologically manifest the features of leukocytoclastic vasculitis. This case represents the first reported incidence of paroxetine-induced urticarial vasculitis, and highlights the need to consider the entire SSRI class as s as a potential cause of the condition.
authors: Drexel University College of Medicine, Department of Dermatology, Philadelphia, PA 19107, USA. jpw32@drexel.edu
authors: John Patrick
authors: JP
authors: Welsh
authors: Carrie Ann
authors: CA
authors: Cusack
authors: Christine
authors: C
authors: Ko
mesh_terms: D003866:Depressive Disorder / Q000188:drug therapy; D006801:Humans; D008875:Middle Aged; D017374:Paroxetine / Q000009:adverse effects* / Q000627:therapeutic use; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects / Q000627:therapeutic use; D012867:Skin / Q000098:blood supply / Q000187:drug effects / Q000473:pathology; D014581:Urticaria / Q000139:chemically induced*; D014657:Vasculitis / Q000139:chemically induced* / Q000175:diagnosis
chemical_list: D017374:Paroxetine; D017367:Selective Serotonin Reuptake Inhibitors