The novel MGC13096 protein is correlated with proliferation.
We report a functional characterisation of the novel protein MGC13096. MGC13096 over-expression restrained proliferation of HEK293T cells. DNA/flow cytometry analysis showed that the over-expression of MGC13096 severely delays cell cycle progression at S phase. Transcription factors such as activator protein-1 (AP-1), cAMP response element binding protein (CREB), nuclear factor of activated T cells (NFAT), NF-kappaB, signal transducer and activator of transcription 1 (STAT1) took part in the process.
Chen
Qiu
Q
College of Life Sciences, Zhejiang University, Hangzhou, PR China.
Yan
Chengqi
C
Yan
Qingfeng
Q
Feng
Lifeng
L
Chen
Jianping
J
Qian
Kaixian
K
D051017:Apoptosis Regulatory Proteins / Q000235:genetics / Q000502:physiology; D002352:Carrier Proteins; D049109:Cell Proliferation; D002478:Cells, Cultured; D017362:Cyclic AMP Response Element-Binding Protein / Q000378:metabolism; D020869:Gene Expression Profiling; D006801:Humans; D008969:Molecular Sequence Data; D008970:Molecular Weight; D016328:NF-kappa B / Q000378:metabolism; D050778:NFATC Transcription Factors / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction; D016196:S Phase / Q000502:physiology; D050794:STAT1 Transcription Factor / Q000378:metabolism; D013997:Time Factors; D018808:Transcription Factor AP-1 / Q000378:metabolism
D051017:Apoptosis Regulatory Proteins; D002352:Carrier Proteins; D017362:Cyclic AMP Response Element-Binding Protein; D016328:NF-kappa B; D050778:NFATC Transcription Factors; C000620221:PDCD2L protein, human; D012333:RNA, Messenger; D050794:STAT1 Transcription Factor; D018808:Transcription Factor AP-1