Variable response to antiplatelet therapy: what does it mean to clinicians?
Ex vivo tests of platelet function show that platelet function and the response to antiplatelet therapy vary markedly from person to person. But just how clinically significant are ex vivo measurements of platelet function, and will changes we make based on such information translate into improved outcomes for patients? The authors summarize what is known and not known about the impact and clinical significance of variable response to antiplatelet therapy.
Falluji
Nezar
N
Linda and Jack Gill Heart Institute, University of Kentucky, Lexington, USA.
Steinhubl
Steven R
SR
D001792:Blood Platelets / Q000187:drug effects; D000077144:Clopidogrel; D006801:Humans; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D010979:Platelet Function Tests; D013988:Ticlopidine / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D017211:Treatment Failure; D016896:Treatment Outcome
D010975:Platelet Aggregation Inhibitors; D000077144:Clopidogrel; D013988:Ticlopidine