title: Cytotoxic isoquinoline alkaloids from the aerial parts of Corydalis incisa.
abstract: Three known isoquinoline alkaloids were isolated from the chloroform-soluble fraction of the methanolic extract of the aerial parts of Corydalis incisa (Papaveraceae) through repeated column chromatography. Their chemical structures were elucidated as corynoline (1), corynoloxine (2) and 6-oxocorynoline (3) using spectroscopic analysis. Compounds 1-3 exhibited cytotoxicity against human A549, SK-OV-3, SK-MEL-2 and HCT15 tumor cells.
authors: College of Pharmacy, Woosuk University, Samrye 565-701, Korea.
authors: Sang Un
authors: SU
authors: Choi
authors: Nam-In
authors: NI
authors: Baek
authors: Sung-Hoon
authors: SH
authors: Kim
authors: Jae Heon
authors: JH
authors: Yang
authors: Jae Soon
authors: JS
authors: Eun
authors: Tae Yong
authors: TY
authors: Shin
authors: Jong Pil
authors: JP
authors: Lim
authors: Jae Hyeok
authors: JH
authors: Lee
authors: Hoon
authors: H
authors: Jeon
authors: Mi-Young
authors: MY
authors: Yun
authors: Kang-Hyun
authors: KH
authors: Leem
authors: Hee Wook
authors: HW
authors: Park
authors: Dae Keun
authors: DK
authors: Kim
mesh_terms: D000470:Alkaloids / Q000302:isolation & purification / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology*; D002448:Cell Adhesion / Q000187:drug effects; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D031311:Corydalis / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007546:Isoquinolines / Q000302:isolation & purification / Q000494:pharmacology*; D015394:Molecular Structure; D009504:Neutrophils / Q000166:cytology; D035261:Plant Components, Aerial / Q000737:chemistry; D013329:Structure-Activity Relationship
chemical_list: D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D007546:Isoquinolines