title: Wavelet-based characterization of vertebral trabecular bone structure from magnetic resonance images at 3 T compared with micro-computed tomographic measurements.
abstract: Trabecular bone structure and bone density contribute to the strength of bone and are important in the study of osteoporosis. Wavelets are a powerful tool in characterizing and quantifying texture in an image. The purpose of this study was to validate wavelets as a tool in computing trabecular bone thickness directly from gray-level images. To this end, eight cylindrical cores of vertebral trabecular bone were imaged using 3-T magnetic resonance imaging (MRI) and micro-computed tomography (microCT). Thickness measurements of the trabecular bone from the wavelet-based analysis were compared with standard 2D structural parameters analogous to bone histomorphometry (MR images) and direct 3D distance transformation methods (microCT images). Additionally, bone volume fraction was determined using each method. The average difference in trabecular thickness between the wavelet and standard methods was less than the size of 1 pixel size for both MRI and microCT analysis. A correlation (R) of .94 for microCT measurements and that of .52 for MRI were found for the bone volume fraction. Based on these results, we conclude that wavelet-based methods deliver results comparable with those from established MR histomorphometric measurements. Because the wavelet transform is more robust with respect to image noise and operates directly on gray-level images, it could be a powerful tool for computing structural bone parameters from MR images acquired using high resolution and thus limited signal scenarios.
authors: MQIR, Department of Radiology, University of California, San Francisco, CA 94143-2520, USA. roland.krug@mrsc.ucsf.edu
authors: Roland
authors: R
authors: Krug
authors: Julio
authors: J
authors: Carballido-Gamio
authors: Andrew J
authors: AJ
authors: Burghardt
authors: Sebastian
authors: S
authors: Haase
authors: John W
authors: JW
authors: Sedat
authors: William C
authors: WC
authors: Moss
authors: Sharmila
authors: S
authors: Majumdar
mesh_terms: D000465:Algorithms; D015519:Bone Density / Q000502:physiology*; D003720:Densitometry / Q000379:methods*; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D066298:In Vitro Techniques; D008279:Magnetic Resonance Imaging / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013131:Spine / Q000033:anatomy & histology* / Q000502:physiology*; D014057:Tomography, X-Ray Computed