title: Hyaline globule-like structures in undifferentiated sarcoma cells of malignant müllerian mixed tumor of the fallopian tube.
abstract: Malignant müllerian mixed tumors (MMMTs) of the fallopian tube are very rare neoplasms, and we present such a case with unusual findings here. A 57-year-old Japanese woman, after she received a medical checkup, underwent salpingo-oophorectomy on the suspicion of ovarian cancer. At the time of operation, the main tumor was present predominantly in the fallopian tube. Microscopically, the tumor consisted of carcinoma and sarcoma components. The carcinoma showed moderately to poorly differentiated adenocarcinoma. The sarcoma consisted of predominantly undifferentiated sarcoma and focally rhabdomyosarcomatous cells with abundant eosinophilic cytoplasm. Immunohistochemically, the differentiation toward rhabdomyosarcoma was confirmed. Interestingly, the cytoplasm of undifferentiated sarcoma cells contained hyaline globule-like structures. These structures showed a positive reaction for PAS, and these structures were not digested by the diastase pretreatment. Ultrastructurally, hyaline globule-like structures corresponded to lysosomes. Finally, pathologists should keep in mind that undifferentiated sarcoma cells in MMMT of the fallopian tube may contain hyaline globule-like structures in the cytoplasm.
authors: Department of Pathology, Kochi Red Cross Hospital, Kochi 780-8562, Japan. nkurodakrch@yahoo.co.jp
authors: Naoto
authors: N
authors: Kuroda
authors: Yasunobu
authors: Y
authors: Inui
authors: Masahiko
authors: M
authors: Ohara
authors: Takashi
authors: T
authors: Hirouchi
authors: Keiko
authors: K
authors: Mizuno
authors: Ayumi
authors: A
authors: Kubo
authors: Yoshihiro
authors: Y
authors: Hayashi
authors: Hideaki
authors: H
authors: Enzan
authors: Gang-Hong
authors: GH
authors: Lee
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology* / Q000648:ultrastructure; D002454:Cell Differentiation; D003593:Cytoplasm / Q000378:metabolism / Q000648:ultrastructure; D004801:Eosine Yellowish-(YS) / Q000378:metabolism; D005185:Fallopian Tube Neoplasms / Q000473:pathology* / Q000648:ultrastructure; D005187:Fallopian Tubes / Q000473:pathology; D005260:Female; D006801:Humans; D006818:Hyalin / Q000378:metabolism / Q000648:ultrastructure*; D008247:Lysosomes / Q000378:metabolism / Q000648:ultrastructure; D046529:Microscopy, Electron, Transmission; D008875:Middle Aged; D018198:Mixed Tumor, Malignant / Q000473:pathology / Q000648:ultrastructure; D018200:Mixed Tumor, Mullerian / Q000473:pathology* / Q000648:ultrastructure; D012208:Rhabdomyosarcoma / Q000473:pathology* / Q000648:ultrastructure
chemical_list: D004801:Eosine Yellowish-(YS)