X-ray crystal structure and antioxidant activity of salidroside, a phenylethanoid glycoside.
The X-ray single-crystal structure of natural salidroside (=2-(4-hydroxyphenyl)ethyl beta-D-glucopyranoside; 1), isolated from Cistanche deserticola, is reported for the first time, as well as its absolute configuration. The radical-scavenging activity of 1 towards the superoxide radical anion (O*2-) was determined experimentally by chemiluminescence measurements of the pyrogallol-luminol system, and compared to that of the corresponding aglycone, i.e., tyrosol (=4-(2-hydroxyethyl)phenol; 2).
Yu
Peizhong
P
Department of Chemistry of Natural Drugs, School of Pharmacy, Fudan University, Shanghai 200032, PR China.
Hu
Changqi
C
Meehan
Edward J
EJ
Chen
Liqing
L
D000975:Antioxidants / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D031671:Cistanche; D018360:Crystallography, X-Ray; D016166:Free Radical Scavengers / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D005960:Glucosides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D010636:Phenols / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018547:Plant Stems
D000975:Antioxidants; D016166:Free Radical Scavengers; D005960:Glucosides; D006027:Glycosides; D010636:Phenols; D010936:Plant Extracts; C009172:rhodioloside