Effect of montelukast in a guinea pig model of cough variant asthma.
Cough variant asthma is known as a major cause of chronic cough. Fundamental features of cough variant asthma are prolonged non-productive cough responding to bronchodilator therapy, no history of wheezing or dyspnea attack, normal cough sensitivity and slightly increased bronchial responsiveness. Recently, we reported the animal model of cough variant asthma. The aim of this study was to clarify the involvement of cysteinyl leukotrienes (cysLTs) in this model by using a specific leukotriene receptor antagonist, montelukast. Cough number and specific airway resistance (sRaw) were measured during the antigen inhalation (1.5 min) and following 18.5 min, which was carried out 72 h after the first antigen inhalation in actively sensitized guinea pigs, and then total cell number and cell differentials in bronchoalveolar lavage fluid (BALF) were measured. Montelukast significantly reduced the antigen re-inhalation-induced cough, increase in sRaw, and increase in total cell number in BALF. In conclusion, cysLTs may play an important part in antigen-induced cough associated with bronchoconstriction and airway inflammation in cough variant asthma.
Nishitsuji
Masaru
M
Respiratory Medicine, Cellular Transplantation Biology, Kanazawa University Graduate School of Medicine, 13-1 takara-machi, 920-8641 Kanazawa, Japan. 02314nishituji@kouseiren-ta.or.jp <02314nishituji@kouseiren-ta.or.jp>
Fujimura
Masaki
M
Oribe
Yoshitaka
Y
Nakao
Shinji
S
D000085:Acetates / Q000627:therapeutic use*; D000403:Airway Resistance; D000818:Animals; D018927:Anti-Asthmatic Agents / Q000627:therapeutic use*; D001249:Asthma / Q000188:drug therapy* / Q000276:immunology; D001985:Bronchial Provocation Tests; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D003371:Cough / Q000188:drug therapy*; D003521:Cyclopropanes; D004195:Disease Models, Animal; D006168:Guinea Pigs; D015289:Leukotrienes / Q000032:analysis; D008297:Male; D010047:Ovalbumin / Q000276:immunology; D011804:Quinolines / Q000627:therapeutic use*; D013440:Sulfides
D000085:Acetates; D018927:Anti-Asthmatic Agents; D003521:Cyclopropanes; D015289:Leukotrienes; D011804:Quinolines; D013440:Sulfides; D010047:Ovalbumin; C093875:montelukast