31P-{1H} echo-planar spectroscopic imaging of the human brain in vivo.
Echo-planar spectroscopic imaging (EPSI) is one of the fastest spectroscopic imaging (SI) methods. It has been applied to (1)H MR spectroscopy (MRS) studies of the human brain in vivo. However, to our knowledge, EPSI with detection of the (31)P nucleus to monitor phosphorus-containing neurometabolites has not yet been considered. In this work, eight different (31)P-{(1)H} EPSI sequence versions with spectral widths ranging from 313 Hz to 2.27 kHz were implemented on a clinical 1.5T whole-body MR tomograph. The sequence versions utilized the heteronuclear nuclear Overhauser effect (NOE) for (31)P signal enhancement. The sensitivity observed in experiments with model solutions was in good agreement with theoretical predictions. In vivo measurements performed on healthy volunteers (N = 16) demonstrated the feasibility of performing two-dimensional (2D) (31)P-{(1)H} EPSI in the human brain, and the technique enabled fast acquisition of well-resolved localized spectra.
Ulrich
M
M
Department of Neuroimaging, Central Institute of Mental Health, Mannheim, Germany. marco.ulrich@zi-mannheim.de
Wokrina
T
T
Ende
G
G
Lang
M
M
Bachert
P
P
D000255:Adenosine Triphosphate / Q000378:metabolism; D000465:Algorithms; D001923:Brain Chemistry; D017352:Echo-Planar Imaging / Q000379:methods*; D005240:Feasibility Studies; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D019047:Phantoms, Imaging; D010710:Phosphates / Q000378:metabolism*; D010759:Phosphorus Isotopes; D012815:Signal Processing, Computer-Assisted
D010710:Phosphates; D010759:Phosphorus Isotopes; D000255:Adenosine Triphosphate