Herpes simplex and varicella zoster viruses: forgotten but not gone.
Herpesvirus infections are common complications of organ transplantation. The most frequent herpesvirus infections are caused by cytomegalovirus (CMV), herpes simplex (HSV) and varicella zoster (VZV). Despite expansion of the therapeutic armamentarium, HSV and VZV continue to cause morbidity and occasional mortality in transplant recipients. Here we review the incidence and risk factors for HSV and VZV disease, their clinical presentation, effects of newer immunosuppressive regimens and prophylaxis for HSV and VZV in solid organ transplant recipients.
Miller
G G
GG
Department of Medicine, Division of Infectious Diseases, Vanderbilt University Medical Center, Nashville, Tennessee, USA. geraldine.miller@vanderbilt.edu
Dummer
J S
JS
D006561:Herpes Simplex / Q000453:epidemiology* / Q000401:mortality / Q000517:prevention & control; D006562:Herpes Zoster / Q000453:epidemiology* / Q000401:mortality / Q000517:prevention & control; D014645:Herpesvirus 3, Human; D006801:Humans; D015994:Incidence; D016377:Organ Transplantation / Q000009:adverse effects*; D011183:Postoperative Complications / Q000821:virology*; D012307:Risk Factors; D018139:Simplexvirus