title: Preparation of thin polymer films with controlled drug release.
abstract: Poly(N-isopropylacrylamide) (PAAm) is a thermal responsive polymer that undergoes a structural change in aqueous solution at its lower critical solution temperature (LCST). PAAm-modified silicon substrates were prepared and the effect of PAAm density on the thermal response of the modified surface was examined in terms of changes in the water contact angle as a basis for applying the structural change of the polymer to controlled drug release. Changes with temperature in the ability to load and release of the modified layer for drug were also examined using 2-acetoxybenzoic acid (aspirin) as a model drug. The amount of PAAm was found to greatly affect the thermal response and the ability to load and release of the modified layer for aspirin.
authors: Department of Industrial Chemistry, Faculty of Engineering, Tokyo University of Science, 12-1 Ichigaya-Funagawara, Tokyo, Japan.
authors: Tatsuya
authors: T
authors: Tsukagoshi
authors: Yukishige
authors: Y
authors: Kondo
authors: Norio
authors: N
authors: Yoshino
mesh_terms: D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D011108:Polymers / Q000737:chemistry*; D012996:Solutions; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties
chemical_list: D004364:Pharmaceutical Preparations; D011108:Polymers; D012996:Solutions