title: Characterization of Ca3SiO5/CaCl2 composite cement for dental application.
abstract: OBJECTIVE
  The purpose of this study was to investigate the effect of CaCl(2) on the setting time, pH values and compressive strength of tricalcium silicate, and the in vitro bioactivity and compatibility of Ca(3)SiO(5)/CaCl(2) composite paste was also studied to explore the possibility for using as a root canal filling material.
  
  
  METHODS
  Composite cements were obtained by mixing Ca(3)SiO(5) and different amounts of CaCl(2) (0, 5%, 10% and 15%) with deionized water as liquid phase. The composite cement and pure tricalcium silicate were compared for setting time, pH value, compressive strength, in vitro bioactivity and compatibility.
  
  
  RESULTS
  With the addition of CaCl(2) from 0% to 15%, the initial setting time and final setting time decreased obviously from 90 to 50 min and from 180 to 90 min, respectively. The compressive strength of the Ca(3)SiO(5)/CaCl(2) composite cement after setting for 7 days increased obviously from 5.28 to 23.46MPa when the content of CaCl(2) increased from 0% to 10%. Furthermore, the paste with up to 15% of CaCl(2) showed good ability to induce the formation of hydroxyapatite (HA), and the dissolution extracts of the Ca(3)SiO(5)/CaCl(2) composite paste also have a stimulatory effect on L929 cell proliferation in a certain concentration range.
  
  
  CONCLUSIONS
  The results indicated that the Ca(3)SiO(5)/CaCl(2) composite cement had good self-setting properties, bioactivity and compatibility, and may be used as a novel root canal filling material.
authors: Department of Oral Pathology, Stomatological College, JiLin University, 418 Ziqiang Street, Changchun City, Jilin Province 130041, PR China.
authors: Xiaohong
authors: X
authors: Wang
authors: Hongchen
authors: H
authors: Sun
authors: Jiang
authors: J
authors: Chang
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D002122:Calcium Chloride; D017610:Calcium Compounds; D049109:Cell Proliferation / Q000187:drug effects; D019245:Compressive Strength; D003738:Dental Cements / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D003799:Dental Stress Analysis; D005347:Fibroblasts / Q000187:drug effects; D006863:Hydrogen-Ion Concentration; D007739:L Cells; D008422:Materials Testing; D051379:Mice; D012387:Root Canal Filling Materials; D017640:Silicates
chemical_list: D001672:Biocompatible Materials; D017610:Calcium Compounds; D003738:Dental Cements; D012387:Root Canal Filling Materials; D017640:Silicates; C506393:tricalcium silicate; D002122:Calcium Chloride