Glomerular binding of anti-dsDNA autoantibodies: the dispute resolved?
The binding of anti-double-stranded DNA (anti-dsDNA) autoantibodies to the glomerular basement membrane (GBM) in lupus nephritis can be explained by two mechanisms: (1) direct crossreactive binding to intrinsic glomerular antigens; (2) nucleosome-mediated binding to heparan sulfate in the GBM. Kalaaji et al. demonstrated using novel techniques that glomerular in vivo-bound antoantibodies bind to nucleosomes/dsDNA derived from apoptotic cells and not to intrinsic glomerular structures.
van Bavel
C C
CC
Nephrology Research Laboratory, Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands.
van der Vlag
J
J
Berden
J H
JH
D000906:Antibodies / Q000276:immunology*; D001323:Autoantibodies / Q000276:immunology*; D004247:DNA / Q000276:immunology*; D006801:Humans
D000906:Antibodies; D001323:Autoantibodies; C051951:antiglomerular basement membrane antibody; D004247:DNA