Melanotic neuroectodermal tumor of infancy: report of a case with myogenic differentiation.
An 8-month-old boy presented with a 6-week history of a skull mass of the anterior fontanelle. The mass was excised, and the histopathologic features were diagnostic for melanotic neuroectodermal tumor of infancy. The tumor showed focal myogenin positivity, which has not been previously reported in this tumor. The patient has no evidence of recurrent tumor 10 months after the excision. No adjuvant therapy was given. In addition, we stained a case of melanotic neuroectodermal tumor of infancy obtained from Columbus Children's Hospital; focal myogenin positivity was present.
Ellison
Dale A
DA
Department of Pathology, Arkansas Children's Hospital and University of Arkansas for Medical Sciences, Little Rock, AR, USA. ellisondalea@uams.edu
Adada
Badih
B
Qualman
Stephen J
SJ
Parham
David M
DM
D000951:Antigens, Neoplasm; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D007633:Keratins / Q000378:metabolism; D008297:Male; D058950:Melanoma-Specific Antigens; D018008:Myogenin / Q000378:metabolism*; D009363:Neoplasm Proteins / Q000378:metabolism; D017600:Neuroectodermal Tumor, Melanotic / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D010751:Phosphopyruvate Hydratase / Q000378:metabolism; D011859:Radiography; D012888:Skull Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D013997:Time Factors; D016896:Treatment Outcome
D000951:Antigens, Neoplasm; D058950:Melanoma-Specific Antigens; D018008:Myogenin; D009363:Neoplasm Proteins; D007633:Keratins; D010751:Phosphopyruvate Hydratase