title: Division of labor: specialization of sphingosine kinases in mast cells.
abstract: Generation of sphingosine-1-phosphate by sphingosine kinases (SphKs) promotes allergic inflammatory diseases, but the roles of the individual SphK isoforms are unclear. Olivera et al. (2007) show that SphK2 regulates mast cell activation whereas SphK1 enhances susceptibility to antigen challenge in vivo.
authors: National Heart, Lung, and Blood Institute, National Institutes of Health, Room 8N109/Bldg. 10, Bethesda, MD 20892, USA. beavenm@nhlbi.nih.gov
authors: Michael A
authors: MA
authors: Beaven
mesh_terms: D000818:Animals; D000941:Antigens / Q000276:immunology; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000201:enzymology / Q000276:immunology; D008407:Mast Cells / Q000201:enzymology* / Q000276:immunology*; D051379:Mice; D017853:Phosphotransferases (Alcohol Group Acceptor) / Q000502:physiology*; D000099157:Sphingosine Kinase
chemical_list: D000941:Antigens; D017853:Phosphotransferases (Alcohol Group Acceptor); D000099157:Sphingosine Kinase