title: Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338.
abstract: Saccharopolyspora erythraea is used for the industrial-scale production of the antibiotic erythromycin A, derivatives of which play a vital role in medicine. The sequenced chromosome of this soil bacterium comprises 8,212,805 base pairs, predicted to encode 7,264 genes. It is circular, like those of the pathogenic actinomycetes Mycobacterium tuberculosis and Corynebacterium diphtheriae, but unlike the linear chromosomes of the model actinomycete Streptomyces coelicolor A3(2) and the closely related Streptomyces avermitilis. The S. erythraea genome contains at least 25 gene clusters for production of known or predicted secondary metabolites, at least 72 genes predicted to confer resistance to a range of common antibiotic classes and many sets of duplicated genes to support its saprophytic lifestyle. The availability of the genome sequence of S. erythraea will improve insight into its biology and facilitate rational development of strains to generate high-titer producers of clinically important antibiotics.
authors: Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK.
authors: Markiyan
authors: M
authors: Oliynyk
authors: Markiyan
authors: M
authors: Samborskyy
authors: John B
authors: JB
authors: Lester
authors: Tatiana
authors: T
authors: Mironenko
authors: Nataliya
authors: N
authors: Scott
authors: Shilo
authors: S
authors: Dickens
authors: Stephen F
authors: SF
authors: Haydock
authors: Peter F
authors: PF
authors: Leadlay
mesh_terms: D002876:Chromosomes, Bacterial / Q000235:genetics; D004352:Drug Resistance, Microbial; D004917:Erythromycin / Q000096:biosynthesis*; D005798:Genes, Bacterial; D016680:Genome, Bacterial; D008969:Molecular Sequence Data; D016930:Saccharopolyspora / Q000235:genetics*; D017422:Sequence Analysis, DNA; D048372:Streptomyces coelicolor / Q000235:genetics
chemical_list: D004917:Erythromycin