Chemistry and biology in search of antimetastatic agents.
A recent publication is a great example of the inherent potential of exploring the chemical space inspired by natural products. Expanding access to chemical space through organic synthesis allows the discovery of valuable new small-molecule mediators of biological activity.
Pérez
Lucy
L
Laboratory for Bioorganic Chemistry, Sloan-Kettering Institute for Cancer Research, New York, New York 10021, USA.
Danishefsky
Samuel J
SJ
D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D001688:Biological Products / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D009362:Neoplasm Metastasis / Q000188:drug therapy*; D020741:rho GTP-Binding Proteins / Q000037:antagonists & inhibitors
D000970:Antineoplastic Agents; D001688:Biological Products; D020741:rho GTP-Binding Proteins