Failure to confirm the association between the FEZ1 gene and schizophrenia in a Japanese population.
Fasciculation and elongation of protein zeta-1 (FEZ1) is a binding partner of Disrupted-In-Schizophrenia 1 (DISC1). Because the DISC1 gene is shown to be a causative gene for psychosis in a Scottish family, the FEZ1 gene may well have importance in mental disease. A previous association study that analyzed polymorphisms of the FEZ1 gene in Japanese patients with schizophrenia and control subjects found significant association of the Asp123Glu polymorphism with schizophrenia. In the present study, we examined two polymorphic markers, rs559668 and rs597570 (Asp123Glu), in the FEZ1 gene to confirm the association in 1920 Japanese patients with schizophrenia and 1920 control subjects. The power to detect an association was more than 0.98. However, we did not detect genotypic associations of either of these two single nucleotide polymorphisms with schizophrenia (p=1 and 0.79, respectively). We concluded that the missense mutation Asp123Glu of the FEZ1 gene is unlikely to play a substantial role in the genetic susceptibility to schizophrenia.
Koga
Minori
M
Department of Medical Genetics, Doctoral Program in Social and Environmental Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan.
Ishiguro
Hiroki
H
Horiuchi
Yasue
Y
Albalushi
Talal
T
Inada
Toshiya
T
Iwata
Nakao
N
Ozaki
Norio
N
Ujike
Hiroshi
H
Muratake
Tatsuyuki
T
Someya
Toshiyuki
T
Arinami
Tadao
T
D048868:Adaptor Proteins, Signal Transducing; D000328:Adult; D019943:Amino Acid Substitution / Q000235:genetics; D044466:Asian People / Q000208:ethnology / Q000235:genetics; D001224:Aspartic Acid / Q000235:genetics; D001921:Brain / Q000378:metabolism* / Q000503:physiopathology; D001923:Brain Chemistry / Q000235:genetics*; D004252:DNA Mutational Analysis; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005820:Genetic Testing; D005838:Genotype; D018698:Glutamic Acid / Q000235:genetics; D006801:Humans; D007564:Japan / Q000208:ethnology; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics; D020125:Mutation, Missense / Q000235:genetics; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism; D011110:Polymorphism, Genetic / Q000235:genetics; D012559:Schizophrenia / Q000208:ethnology* / Q000235:genetics* / Q000378:metabolism; D025521:Tumor Suppressor Proteins / Q000235:genetics*
D048868:Adaptor Proteins, Signal Transducing; C412476:DISC1 protein, human; D004268:DNA-Binding Proteins; C528597:FEZ1 protein, human; D005819:Genetic Markers; C118711:LZTS1 protein, human; D009419:Nerve Tissue Proteins; D025521:Tumor Suppressor Proteins; D001224:Aspartic Acid; D018698:Glutamic Acid