Antiarrhythmic activity of a membrane-protecting agent Sal'magin in rats with aconitine-induced arrhythmias.
Antiarrhythmic activity of a membrane-protecting agent Sal'magin was studied in rats with aconitine-induced cardiac arrhythmias. The test preparation was more potent than amiodaron in producing the antiarrhythmic effect in rats with Na(+)-induced cardiac arrhythmias. The absence of side effects, low toxicity, and high animal survival rate under experimental conditions suggest that Sal'magin holds much promise as an antiarrhythmic drug in clinical practice.
Klekot
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Vinnitsa National Medical University.
D000157:Aconitine / Q000633:toxicity; D000638:Amiodarone / Q000627:therapeutic use; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D001145:Arrhythmias, Cardiac / Q000139:chemically induced* / Q000188:drug therapy*; D005260:Female; D008297:Male; D051381:Rats; D012459:Salicylates / Q000627:therapeutic use*; D015222:Sodium Channels / Q000378:metabolism
D000889:Anti-Arrhythmia Agents; D012459:Salicylates; D015222:Sodium Channels; C496892:Magnesium Salicylate; D000638:Amiodarone; D000157:Aconitine