A correlative study on red blood cell parameters and urine trans, trans-muconic acid in subjects with occupational benzene exposure.
Benzene is of particular concern because of recent research indicating that benzene exposure can result in toxicity. The hematotoxic effect of benzene is mentioned. However, there is little knowledge about the correlation between the biomarker of benzene exposure and changes in red blood cell parameters. Here, the correlation between the urine trans, trans-muconic acid (ttMA) level and red blood cell parameters were studied in 30 Thai subjects at risk. The regression analysis shows no significant correlation between urine ttMA and any studied red cell parameters (Hb, MCV or MCH). Based on our hematologic data, we proposed that only investigation for the urine ttMA might be not sufficient in detection of alteration in red blood cell parameters in the exposed population. Combinations between biomarker and hematological test are recommended.
Wiwanitkit
Viroj
V
Department of Laboratory Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. wviroj@pioneer.netserv.chula.ac.th
Soogarun
Suphan
S
Suwansaksri
Jamsai
J
D001554:Benzene / Q000009:adverse effects*; D015415:Biomarkers / Q000652:urine; D004909:Erythrocyte Indices / Q000187:drug effects*; D006454:Hemoglobins / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D016273:Occupational Exposure / Q000009:adverse effects*; D016272:Occupational Health; D012044:Regression Analysis; D013011:Sorbic Acid / Q000031:analogs & derivatives* / Q000378:metabolism
D015415:Biomarkers; D006454:Hemoglobins; C005939:muconic acid; D001554:Benzene; D013011:Sorbic Acid