title: Stereospecific construction of substituted piperidines. Synthesis of (-)-paroxetine and (+)-laccarin.
abstract: Short and efficient enantioselective syntheses of (-)-paroxetine and (+)-laccarin are described based on the highly stereospecific cleavage of C(3)-substituted 1,3-cyclic sulfamidates.
authors: School of Chemistry, University of Bristol, Bristol, UKBS8 1TS.
authors: John F
authors: JF
authors: Bower
authors: Thomas
authors: T
authors: Riis-Johannessen
authors: Peter
authors: P
authors: Szeto
authors: Andrew J
authors: AJ
authors: Whitehead
authors: Timothy
authors: T
authors: Gallagher
mesh_terms: D007211:Indoles / Q000138:chemical synthesis*; D017374:Paroxetine / Q000138:chemical synthesis*; D010880:Piperidines / Q000138:chemical synthesis*; D013237:Stereoisomerism; D013451:Sulfonic Acids / Q000737:chemistry
chemical_list: D007211:Indoles; D010880:Piperidines; D013451:Sulfonic Acids; C486126:laccarin A; D017374:Paroxetine; C005741:sulfamic acid