Promotion of skin epithelial cell migration and wound healing by a 2-benzazepine derivative.
Re-epithelialization is an important event in the healing of skin wounds. We have now shown that a 2-benzazepine derivative, N-(2,2,2-trifluoroethyl)-8-methoxy-4-methyl-2-benzazepin-3-one (compound A), facilitated the migration of human keratinocyte HaCat cells in an in vitro model of wound healing and inhibited the attachment of these cells to a collagen matrix. Topical application of compound A also promoted the healing of skin wounds in mice. Our results suggest that compound A promotes the repair of skin wounds by facilitating epithelial cell migration and that this 2-benzazepine derivative is a potential new drug for the treatment of such wounds.
Matsuura
Kenji
K
Department of Pharmacology, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-Kogushi, Ube, and Department of Surgical Pathology, Yamaguchi University Hospital, 755-8505, Japan.
Kuratani
Tomohiro
T
Gondo
Toshikazu
T
Kamimura
Akio
A
Inui
Makoto
M
D000818:Animals; D001552:Benzazepines / Q000494:pharmacology*; D002448:Cell Adhesion / Q000187:drug effects; D002461:Cell Line, Transformed; D002465:Cell Movement / Q000187:drug effects*; D024042:Collagen Type I / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D006801:Humans; D015603:Keratinocytes / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D012867:Skin / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D013997:Time Factors; D014945:Wound Healing / Q000187:drug effects*
D001552:Benzazepines; D024042:Collagen Type I