title: C-terminal pentapeptide of osteogenic growth peptide regulates hematopoiesis in early stage.
abstract: Osteogenic growth peptide (OGP) was characterized in regenerating bone marrow, which can increase osteogenesis and hematopoiesis. The carboxy-terminal pentapeptide is a naturally occurring human and murine mitogen equipotent to OGP. In this study, we evaluated the potential role of OGP10-14 in regulation of hematopoiesis in human hematopoietic stem cells and animal model. Our results showed CD34+ stem cells from umbilical cord blood (UBC) were significantly increased in OGP10-14 treated samples, which is nearly equivalent to the results obtained from the combinations of IL3, IL11, G-CSF, and EPO group. OGP10-14 can also stimulate the differentiation of stem cells from bone marrow at the level of noncommitted progenitor stem cells, thus increasing the number of reconstituted red and white cells as well as platelets after injected i.m. everyday continuing for 5 days in hematopoietic function damage mice comparing with the OGP-untreated group. These data implicate that the role of OGP10-14 regulating hematopoiesis is in the early stage of the whole hematopoietic growth factors (HGFs) regulating network, just like the position of interleukin 13 in the hematopoiesis network.
authors: Beijing Institute of Biotechnology, Beijing, 100850 People's Republic of China. jiaozi0927@126.com
authors: Zhong
authors: Z
authors: Hui
authors: Liu
authors: L
authors: Yu
authors: Yang
authors: Y
authors: Xiaoli
authors: He
authors: H
authors: Xiang
authors: Zhao
authors: Z
authors: Fan
authors: Hou
authors: H
authors: Ningbo
authors: Yuan
authors: Y
authors: Zhigang
authors: Li
authors: L
authors: Ping
authors: Zhang
authors: Z
authors: Yanhong
authors: Ma
authors: M
authors: Qingjun
mesh_terms: D000818:Animals; D018952:Antigens, CD34 / Q000378:metabolism; D001854:Bone Marrow Cells / Q000166:cytology / Q000502:physiology; D016207:Cytokines / Q000378:metabolism; D005260:Female; D005312:Fetal Blood / Q000166:cytology; D006410:Hematopoiesis / Q000502:physiology*; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000502:physiology; D006657:Histones / Q000235:genetics / Q000378:metabolism; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D013234:Stem Cells
chemical_list: D018952:Antigens, CD34; D016207:Cytokines; D006657:Histones; D036341:Intercellular Signaling Peptides and Proteins; C074533:osteogenic growth peptide