[Effects of monofluorphosphate and alphaD3 on the bone mineral density of mandibular of ovariectomy rats].
OBJECTIVE
To investigate the effects of monofluorphosphate and alphaD3 on the bone mineral density of mandibular of ovariectomy rats.


METHODS
39 female Sprague-Dawley rats about 90 days of age were randomly divided into the following treatment groups and treated for 12 weeks: SHAM group, OVX group, MFP group, MFP+alphaD3 group. Rats of MFP group received monofluorphosphate by gastric feeding. Rats of MFP+alphaD3 group received monofluorphosphate and alphatD3 by gastric feeding. The femur and the mandibles were collected for histomorphometry and bone mineral density measurement.


RESULTS
The bone area, bone thick, and bone mineral density of femur in the OVX group were significantly lower than those of other groups, while the trabecular separation of the OVX group was significantly higher than that of other groups. The bone mineral density of mandible was increased in OVX group and MFP+alphaD3 group compared with SHAM group.


CONCLUSIONS
Monofluorphosphate and alphaD3 can obviously increase the mass of mandible. The bone mineral density of femur decreased after ovariectomy while it increased in mandibular.
Zhou
Xiong-wen
XW
Dept. of Stomatology, Xiangya Hospital of Central South University, Changsha 410008, China.
Jian
Xin-chun
XC
Ren
Li-feng
LF
Liu
Ying-chun
YC
D000818:Animals; D015519:Bone Density; D001842:Bone and Bones; D005260:Female; D005269:Femur; D006801:Humans; D008334:Mandible; D010052:Ovariectomy; D051381:Rats; D017207:Rats, Sprague-Dawley