Isolation and syntheses of polymethoxyflavones and hydroxylated polymethoxyflavones as inhibitors of HL-60 cell lines.
Fifteen polymethoxyflavones (PMFs) and hydroxylated PMFs were isolated from sweet orange (Citrus sinensis) peel extract and synthesized to investigate their biological activity. All obtained compounds were tested in HL-60 cancer cell proliferation and apoptosis induction assays. While some PMFs and hydroxylated PMFs had moderate anti-carcinogenic activities, 5-hydroxy-6,7,8,3',4'-pentamethoxyflavone and 5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone showed strong inhibitory activities against the proliferation and induced apoptosis of HL-60 cell lines.
Li
Shiming
S
Department of Food Science, Rutgers University, 65 Dudley Road, New Brunswick, NJ 08901-8520, USA. shiming.li@roche.com
Pan
Min-Hsiung
MH
Lai
Ching-Shu
CS
Lo
Chih-Yu
CY
Dushenkov
Slavik
S
Ho
Chi-Tang
CT
D016588:Anticarcinogenic Agents / Q000138:chemical synthesis / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis* / Q000302:isolation & purification / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D002957:Citrus / Q000737:chemistry*; D047309:Flavones / Q000302:isolation & purification / Q000502:physiology*; D005638:Fruit / Q000737:chemistry; D018922:HL-60 Cells; D006801:Humans; D006900:Hydroxylation; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D010936:Plant Extracts / Q000737:chemistry; D021241:Spectrometry, Mass, Electrospray Ionization; D013056:Spectrophotometry, Ultraviolet
D016588:Anticarcinogenic Agents; D000972:Antineoplastic Agents, Phytogenic; D047309:Flavones; D007202:Indicators and Reagents; D010936:Plant Extracts