title: The association between cord pH at birth and intellectual function in childhood.
abstract: BACKGROUND
  Acidemia at birth is very common but little is known about its long-term consequences.
  
  
  OBJECTIVE
  To determine if pH at birth is related to established tests of intellectual function.
  
  
  METHODS
  School children aged 6-8, for whom obstetric data were available, who had been delivered after labour at term, and had an umbilical cord arterial pH>7.00 (i.e. that was not extremely acidemic). STUDY DESIGN/OUTCOMES: Retrospective cohort study correlating birth and arterial pH data with childhood tests for non-verbal intelligence, grammar comprehension and literacy.
  
  
  METHODS
  Relationships between pH and cognitive measures were analysed with parametric correlations. Partial correlations were used to examine these relationships, controlling for possible confounding factors.
  
  
  RESULTS
  Arterial pH was significantly negatively correlated with literacy (p=0.001) and with non-verbal intelligence (p=0.033).
  
  
  CONCLUSIONS
  Lower arterial pH is associated with higher scores on literacy and non-verbal intelligence tests at ages 6-8. This is unlikely to be a chance finding and is further evidence that acidemia in isolation should not be considered an adverse outcome. Further research on the relationship between labour and long-term cognitive measures is required.
authors: Department of Experimental Psychology, University of Oxford, Oxford, UK.
authors: Elena
authors: E
authors: Svirko
authors: Jane
authors: J
authors: Mellanby
authors: Lawrence
authors: L
authors: Impey
mesh_terms: D002648:Child; D015331:Cohort Studies; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007231:Infant, Newborn; D007360:Intelligence / Q000502:physiology*; D007361:Intelligence Tests; D011247:Pregnancy; D012189:Retrospective Studies