Mouse Piwi-interacting RNAs are 2'-O-methylated at their 3' termini.
Piwi-interacting RNAs (piRNAs) are a novel class of small RNAs that are expressed specifically and abundantly in male germ cells. Here we report that the 3' termini of piRNAs are 2'-O-methylated; this modification may have important implications for the biogenesis and function of piRNAs.
Kirino
Yohei
Y
Department of Pathology and Laboratory Medicine, Division of Neuropathology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.
Mourelatos
Zissimos
Z
D000818:Animals; D060565:Argonaute Proteins; D008297:Male; D008745:Methylation; D051379:Mice; D010710:Phosphates / Q000378:metabolism; D011506:Proteins / Q000378:metabolism*; D012313:RNA / Q000737:chemistry* / Q000378:metabolism*; D012323:RNA Processing, Post-Transcriptional; D013737:Testis / Q000378:metabolism
D060565:Argonaute Proteins; D010710:Phosphates; C448522:Piwil1 protein, mouse; D011506:Proteins; D012313:RNA