Relationship between human leucocyte antigen class I and class II and chronic idiopathic urticaria associated with aspirin and/or NSAIDs hypersensitivity.
BACKGROUND
HLA genes play a role in the predisposition of several diseases. The aim was to analyze the prevalence of HLA class I phenotypes and HLA-DRB1* genotype in patients with CIU associated with ASA and NSAIDs hypersensitivity (AICU).


METHODS
69 patients with AICU, and 200 healthy subjects.


RESULTS
Subjects with HLA-B44 and HLA-Cw5 antigens were more represented in patients with AICU than in control group. Subjects with HLA-A11, HLA-B13, HLACw4, and HLA-Cw7 antigen were more represented in control group than in patients with AICU. Multiple logistic regression demonstrated an association of HLA-Cw4 and HLA-Cw7 with a lower risk of AICU, whereas carriers of HLA-B44 phenotype had a higher risk of AICU. No differences were found between patients and controls as regards to HLA-DRB1* genotype.


CONCLUSIONS
We observed an association between some HLA class-I antigens and AICU. To the best of our knowledge this is the first description of such association.
Pacor
Maria Luisa
ML
Dipartimento de Medicina Clinica e Sperimentale, Policlinico G.B. Rossi, Università di Verona, Italy.
Di Lorenzo
Gabriele
G
Mansueto
Pasquale
P
Martinelli
Nicola
N
Esposito-Pellitteri
Maria
M
Pradella
Paola
P
Uxa
Laura
L
Di Fede
Gaetana
G
Rini
GiovamBattista
G
Corrocher
Roberto
R
D000328:Adult; D000483:Alleles; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D001241:Aspirin / Q000009:adverse effects*; D016022:Case-Control Studies; D004342:Drug Hypersensitivity / Q000150:complications* / Q000235:genetics / Q000276:immunology*; D005260:Female; D005787:Gene Frequency; D005802:Genes, MHC Class II; D005838:Genotype; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D015395:Histocompatibility Antigens Class I / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D012307:Risk Factors; D014581:Urticaria / Q000209:etiology* / Q000235:genetics / Q000276:immunology*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; D015395:Histocompatibility Antigens Class I; D001241:Aspirin