Small RNAs controlling iron metabolism.
Iron is one of the most important metals in the metabolism of many organisms, including bacteria, in which it serves as a cofactor in multiple enzymatic reactions. Most of the earlier research on iron regulation in bacteria has focused on the transcriptional regulator Fur and its effect on the many genes involved in iron uptake. More recent work demonstrates the essential role of a small regulatory RNA, RyhB, in iron metabolism. RyhB downregulates a large number of transcripts encoding iron-using proteins, resulting in redistribution of the intracellular iron. Recent advances have been made in the understanding of the small RNAs that modulate the intracellular iron usage in different organisms such as, Escherichia coli, Pseudomonas aeruginosa, Vibrio cholerae, Shigella flexneri and cyanobacteria.
Massé
Eric
E
Université de Sherbrooke, Département de Biochimie, 3001 12e Avenue, Sherbrooke, Québec J1H 5N4, Canada. eric.masse@usherbrooke.ca
Salvail
Hubert
H
Desnoyers
Guillaume
G
Arguin
Mélina
M
D001419:Bacteria / Q000235:genetics / Q000378:metabolism*; D001426:Bacterial Proteins / Q000235:genetics; D015964:Gene Expression Regulation, Bacterial; D007501:Iron / Q000378:metabolism*; D012329:RNA, Bacterial / Q000378:metabolism*; D022661:RNA, Untranslated / Q000378:metabolism*; D012097:Repressor Proteins / Q000235:genetics
D001426:Bacterial Proteins; D012329:RNA, Bacterial; D022661:RNA, Untranslated; D012097:Repressor Proteins; C068477:ferric uptake regulating proteins, bacterial; D007501:Iron