Conduction velocity distribution: early diagnostic tool for peripheral neuropathies.
In order to get early information on the functional state of smaller myelinated fibers this article investigated the applicability of conduction velocity distribution on compound action potential recorded in experimentally demyelinated frog sciatic nerve. Conduction velocity distribution histograms were estimated by using the mathematical model the authors enhanced. The results suggest that by using appropriate conduction velocity distribution model the diagnosis time in demyelinating neuropathy may be shortened at least three times as compared with conventional conduction velocity assessment. Therefore, it may be concluded that a well-defined model designed for the estimation of the conduction velocity distribution may be used as a diagnostic tool for the early phase of peripheral demyelinating neuropathies.
Kiziltan
Erhan
E
Department of Biophysics, Karaelmas University, Zonguldak, Turkey. ekiziltan@med.karaelmas.edu.tr
Dalkilic
Nizamettin
N
Guney
Figen Bayramoglu
FB
Pehlivan
Ferit
F
D000200:Action Potentials / Q000502:physiology; D000818:Animals; D001001:Anura; D003711:Demyelinating Diseases / Q000139:chemically induced / Q000175:diagnosis / Q000503:physiopathology; D004195:Disease Models, Animal; D004558:Electric Stimulation / Q000379:methods; D008244:Lysophosphatidylcholines; D009431:Neural Conduction / Q000502:physiology*; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology*; D011930:Reaction Time / Q000502:physiology* / Q000528:radiation effects; D012584:Sciatic Nerve / Q000503:physiopathology; D018709:Statistics, Nonparametric; D013997:Time Factors
D008244:Lysophosphatidylcholines