Serum levels of CA19-9 in patients with nonmalignant respiratory diseases.
CA19-9 is a specific tumor marker in patients with gastrointestinal cancer; however, some patients with respiratory disease can have elevated serum levels of CA19-9 as well. In this study we evaluated serum CA19-9 levels of patients with nonmalignant respiratory diseases. We also estimated the prognostic significance of elevated serum levels of CA19-9 in patients with interstitial lung diseases. The study included 554 patients who had been diagnosed at our hospital during the period of 1984-2005. Serum CA19-9 levels in these patients were measured with a commercially available kit. Elevated levels (>37 U/mL) of CA19-9 were observed in 30.7% of patients with lung cancer. Furthermore, 38.9% of patients with idiopathic interstitial pneumonia (IIP), collagen disease-associated pulmonary fibrosis (CDPF), diffuse panbronchiolitis (DPB), and bronchiectasis had elevated serum CA19-9 levels. Survival rates were significantly lower in patients with interstitial lung diseases (IIP and CDPF) and elevated serum CA19-9 levels than in those with levels in the normal range (P=0.0065). Serum CA19-9 was elevated in some patients with nonmalignant diffuse lung diseases. Therefore, clinicians should pay attention to the evidence that increased serum CA19-9 levels can be found in nonmalignant respiratory disease patients. In patients with IIP and CDPF, elevated serum CA19-9 levels may be related to poor prognosis.
Kodama
Takahide
T
Division of Respiratory Medicine, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Japan.
Satoh
Hiroaki
H
Ishikawa
Hiroichi
H
Ohtsuka
Morio
M
D001987:Bronchiectasis / Q000097:blood / Q000401:mortality / Q000473:pathology; D001988:Bronchiolitis / Q000097:blood / Q000401:mortality / Q000473:pathology; D018395:CA-19-9 Antigen / Q000097:blood*; D003095:Collagen Diseases / Q000097:blood / Q000150:complications / Q000175:diagnosis; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008171:Lung Diseases / Q000097:blood* / Q000175:diagnosis / Q000401:mortality; D017563:Lung Diseases, Interstitial / Q000097:blood / Q000175:diagnosis / Q000401:mortality; D008175:Lung Neoplasms / Q000097:blood / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D011658:Pulmonary Fibrosis / Q000097:blood / Q000175:diagnosis / Q000209:etiology; D015996:Survival Rate
D018395:CA-19-9 Antigen