title: Study of the effects on DNA of two novel nucleoside derivatives synthesized as potential anti-HIV agents.
abstract: The pursuit of antiviral active compounds against different classes of viruses, in particular HIV, HBV, and HTLV is an area of important and intense research. In the current study, two novel nucleoside derivatives belonging to a new class of isoxazolidine were successfully synthesized as potential anti-HIV agents by replacement of the furanose ring by a N,O-heterocyclic ring Both compounds were investigated for biological activity, namely, mutagenic and antimutagenic properties. Using Salmonella typhimurium strains TA97, TA100, and TA102, both compounds proved to be nonmutagenic, which may be considered an encouraging result to further elucidate other biological activities. Antimutagenic testing of the synthesized compounds revealed that they are active against the base-pair substitution mutagen sodium azide. However, they did not show any indication as antimutagenic agents against hydrogen peroxide and mitomycin C (oxidative mutagens) or against nitrophenylenediamine (a base-pair substitution and frameshift mutagen). Structure-activity relationship is also discussed. Testing these compounds as antiviral agents is highly recommended.
authors: Department of Biological Sciences, Yarmouk University, Irbid, Jordan. mass7000@yahoo.com
authors: Ahmed O
authors: AO
authors: Maslat
authors: Majdi
authors: M
authors: Bkhaitan
authors: Ghassan Abu
authors: GA
authors: Sheikha
mesh_terms: D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D004247:DNA / Q000378:metabolism*; D007555:Isoxazoles / Q000138:chemical synthesis* / Q000737:chemistry; D009152:Mutagenicity Tests; D009705:Nucleosides / Q000737:chemistry*; D012486:Salmonella typhimurium / Q000187:drug effects* / Q000235:genetics; D019810:Sodium Azide / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D019380:Anti-HIV Agents; D007555:Isoxazoles; D009705:Nucleosides; D004247:DNA; D019810:Sodium Azide