Two isoforms of the human cyclin C gene are expressed differentially suggesting that they may have distinct functions.
Cyclin C is a highly conserved protein that is involved in divergent cellular processes. The exact roles of its isoforms are presently not very well defined and it is possible that there is a functional divergence amongst them. We therefore sought to assess the expression pattern of cyclin C1 and C2 isoforms in various human tissues and in cell cycle by using real-time PCR experiments. Our findings strongly suggest that the C2 isoform may play a presently unexplored and important role in mammalian testis and probably this isoform is the one that is mainly implicated in cell cycle regulation.
Katona
R L
RL
Department of Genetics and Tumor Cell Biology, MS350, Room D5003, St. Jude Children's Research Hospital 332 N. Lauderdale, Memphis, TN 38105-2794, USA. katona@brc.hu
Loyer
P
P
Roby
Sarah K
SK
Lahti
Jill M
JM
D000818:Animals; D002448:Cell Adhesion; D002453:Cell Cycle; D017124:Conserved Sequence; D056745:Cyclin C; D016213:Cyclins / Q000235:genetics* / Q000502:physiology; D005786:Gene Expression Regulation; D006801:Humans; D008297:Male; D008322:Mammals; D020033:Protein Isoforms / Q000235:genetics / Q000502:physiology; D013737:Testis / Q000166:cytology
C503674:CCNC protein, human; D056745:Cyclin C; D016213:Cyclins; D020033:Protein Isoforms