Peripapillary schisis in glaucoma patients with narrow angles and increased intraocular pressure.
OBJECTIVE
To describe two cases of peripapillary retinal schisis in patients with glaucoma without evidence of optic nerve pits, pseudopits, or X-linked retinoschisis.


METHODS
Two observational case reports and literature review.


METHODS
Imaging of the peripapillary nerve fiber layer and schisis cavities was completed in two patients, and one patient was followed over time.


RESULTS
The first patient, diagnosed with narrow angle glaucoma, was noted to have peripapillary schisis in the right eye with matching changes on visual field and optical coherence tomographic (OCT) results. Follow-up examination revealed that the schisis disappeared in the right eye while appearing in the left. The findings were verified with high-speed ultra-high-resolution OCT performed in both eyes. The second case involved a patient with anatomically narrow angles, high intraocular pressure (IOP), and peripapillary schisis extending into the macula.


CONCLUSIONS
Peripapillary retinoschisis may represent a unique sequelae of intraocular fluctuations in patients with uncontrolled glaucoma. Further studies are needed to better understand this disease process.
Kahook
Malik Y
MY
UPMC Eye Center, Eye and Ear Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA.
Noecker
Robert J
RJ
Ishikawa
Hiroshi
H
Wollstein
Gadi
G
Kagemann
Larry
L
Wojtkowski
Maciej
M
Duker
Jay S
JS
Srinivasan
Vivek J
VJ
Fujimoto
James G
JG
Schuman
Joel S
JS
D005260:Female; D015812:Glaucoma, Angle-Closure / Q000150:complications* / Q000503:physiopathology; D006801:Humans; D007429:Intraocular Pressure; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology; D009898:Optic Disk; D012165:Retinal Ganglion Cells / Q000473:pathology; D041441:Retinoschisis / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D041623:Tomography, Optical Coherence; D014794:Visual Fields