Allergic reaction to fluorescein dye: successful one-day desensitization.
METHODS
An 86-year-old woman developed IgE-mediated generalized urticaria after a second fluorescein injection. A one-day desensitization protocol was successfully administered that permitted continuation of angiography for deteriorating vision.


CONCLUSIONS
We review the literature on adverse events associated with administration of fluorescein and suggest guidelines for testing and desensitization.
Knowles
Sandra R
SR
Division of Clinical Pharmacology, Department of Medicine, Sunnybrook Health Sciences Centre and the University of Toronto, Toronto, ON. sandra.knowles@sw.ca
Weber
Elizabeth A
EA
Berbrayer
Carolyn S
CS
D000369:Aged, 80 and over; D003888:Desensitization, Immunologic / Q000379:methods*; D004342:Drug Hypersensitivity / Q000209:etiology / Q000628:therapy*; D005260:Female; D019793:Fluorescein / Q000009:adverse effects*; D005451:Fluorescein Angiography; D005456:Fluorescent Dyes / Q000009:adverse effects*; D006801:Humans; D013997:Time Factors; D014581:Urticaria / Q000139:chemically induced / Q000628:therapy*
D005456:Fluorescent Dyes; D019793:Fluorescein