title: Synthesis and biological activity of 5-aza-ellipticine derivatives.
abstract: Novel 5-aza-ellipticine derivatives were synthesized and tested as antitumor agents. The new compounds were prepared more readily than the analogous ellipticine derivatives, which are known to be potent anti-tumor agents Although the novel 5-aza-ellipticine derivatives are not as biologically active as their corresponding ellipticine analogues, the new compounds represent a new, readily accessible class of heteroaromatic catalytic inhibitors of topoisomerase II and possible anti-tumor agents.
authors: Structural Biophysics Laboratory, Molecular Aspects of Drug Design Section, Structural Biophysics Laboratory, NCI-Frederick, PO Box B Frederick, MD 21702, USA.
authors: Deborah L
authors: DL
authors: Moody
authors: Marcin
authors: M
authors: Dyba
authors: Teresa
authors: T
authors: Kosakowska-Cholody
authors: Nadya I
authors: NI
authors: Tarasova
authors: Christopher J
authors: CJ
authors: Michejda
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001372:Aza Compounds / Q000138:chemical synthesis / Q000494:pharmacology; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D004611:Ellipticines / Q000138:chemical synthesis* / Q000494:pharmacology*; D006801:Humans; D020128:Inhibitory Concentration 50; D013329:Structure-Activity Relationship; D059005:Topoisomerase II Inhibitors
chemical_list: D000970:Antineoplastic Agents; D001372:Aza Compounds; D004611:Ellipticines; D059005:Topoisomerase II Inhibitors