Polyunsaturation in lipid membranes: dynamic properties and lateral pressure profiles.
We elucidate the influence of unsaturation on single-component membrane properties, focusing on their dynamical aspects and lateral pressure profiles across the membrane. To this end, we employ atomistic molecular dynamics simulations to study five different membrane systems with varying degrees of unsaturation, starting from saturated membranes and systematically increasing the level of unsaturation, ending up with a bilayer of phospholipids containing the docosahexaenoic acid. For an increasing level of unsaturation, we find considerable effects on dynamical properties, such as accelerated dynamics of the phosphocholine head groups and glycerol backbones and speeded up rotational dynamics of the lipid molecules. The lateral pressure profile is found to be altered by the degree of unsaturation. For an increasing number of double bonds, the peak in the middle of the bilayer decreases. This is compensated for by changes in the membrane-water interface region in terms of increasing peak heights of the lateral pressure profile. Implications of the findings are briefly discussed.
Ollila
Samuli
S
Laboratory of Physics and Helsinki Institute of Physics, Helsinki University of Technology, P.O. Box 1100, FI-02015 HUT, Finland.
Hyvönen
Marja T
MT
Vattulainen
Ilpo
I
D015060:1,2-Dipalmitoylphosphatidylcholine / Q000737:chemistry; D000465:Algorithms; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003198:Computer Simulation; D004058:Diffusion; D005231:Fatty Acids, Unsaturated / Q000737:chemistry*; D005990:Glycerol / Q000737:chemistry; D006838:Hydrocarbons / Q000737:chemistry; D008051:Lipid Bilayers / Q000737:chemistry*; D008055:Lipids / Q000737:chemistry*; D008956:Models, Chemical; D010713:Phosphatidylcholines / Q000737:chemistry; D010743:Phospholipids; D011312:Pressure
D005231:Fatty Acids, Unsaturated; D006838:Hydrocarbons; D008051:Lipid Bilayers; D008055:Lipids; D010713:Phosphatidylcholines; D010743:Phospholipids; D015060:1,2-Dipalmitoylphosphatidylcholine; D005990:Glycerol