Cell therapy of comatose states.
We demonstrated that liquor from adult humans can maintain proliferative activity of cells of immature nervous tissue in vitro. The paper presents the results of a retrospective clinical study of the efficiency of cell therapy in the treatment of II-III degree comatose patients with severe brain injury. Cell suspension consisting of cells derived from immature nervous and hemopoietic tissues was injected into the recipient subarachnoidal space through a cerebrospinal puncture. The mortality in the study group was 8% vs. 56% in the control group. The 1.5-year follow-up demonstrated significantly better quality of life in patients receiving cell therapy in comparison with patients of the control group. Cell therapy proved to be ineffective for patients in a comatose state caused by hypoxic encephalopathy. The study demonstrated the efficiency of cell therapy in patients with severe brain injury during the acute period of the disease.
Seledtsov
V I
VI
Institute of Clinical Immunology, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk. vs@online.nsk.su
Rabinovich
S S
SS
Parlyuk
O V
OV
Poveshchenko
O V
OV
Astrakov
S V
SV
Samarin
D M
DM
Seledtsova
G V
GV
Senyukov
V V
VV
Taraban
V Ya
VY
Kozlov
V A
VA
D000328:Adult; D016022:Case-Control Studies; D002457:Cell Extracts / Q000494:pharmacology; D049109:Cell Proliferation / Q000187:drug effects; D064987:Cell- and Tissue-Based Therapy / Q000379:methods*; D020207:Coma, Post-Head Injury / Q000628:therapy*; D020833:Diffuse Axonal Injury / Q000473:pathology*; D004569:Electroencephalography; D005069:Evaluation Studies as Topic; D005260:Female; D016332:Fetal Tissue Transplantation / Q000379:methods*; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006801:Humans; D002534:Hypoxia, Brain / Q000628:therapy*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009474:Neurons / Q000637:transplantation*; D013346:Subarachnoid Space; D016896:Treatment Outcome; D018608:Ultrasonography, Doppler
D002457:Cell Extracts