Cl- conduction of GABA(A) receptor complex on synaptic membranes in rat cortex at the early stage of chronic cerebral epileptization.
Experiments on Wistar rats showed that muscimol-stimulated Cl(-) conduction of synaptoneurosomes, isolated from the cerebral cortex increased after 5-day systemic treatment with subconvulsive doses of pentylene tetrasole during the initial stage of pharmacological pentylene tetrasole kindling, characterized by gradually augmenting convulsive readiness of the brain. This indicates an increase in functional activity of the GABA(A) receptor/Cl(-) ionophore complex.
Rebrov
I G
IG
Laboratory of Epileptogenesis, Institute of Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow.
Karpova
M N
MN
Andreev
A A
AA
Klishina
N Yu
NY
Kalinina
M V
MV
Kuzina
O S
OS
Kuznetsova
L V
LV
D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism*; D002712:Chlorides / Q000378:metabolism*; D003292:Convulsants / Q000633:toxicity; D004827:Epilepsy / Q000139:chemically induced / Q000378:metabolism*; D008297:Male; D010433:Pentylenetetrazole / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar; D011963:Receptors, GABA-A / Q000378:metabolism*; D013570:Synaptic Membranes / Q000378:metabolism*
D002712:Chlorides; D003292:Convulsants; D011963:Receptors, GABA-A; D010433:Pentylenetetrazole