title: The Bxs6 locus of BXSB mice is sufficient for high-level expression of gp70 and the production of gp70 immune complexes.
abstract: High levels of the retroviral envelope protein gp70 and gp70 immune complexes have been linked to a single locus on chromosome 13 (Bxs6) in the BXSB model, to which linkage of nephritis was also seen. Congenic lines containing the BXSB Bxs6 interval on a non-autoimmune C57BL/10 background were bred in the presence or absence of the BXSB Y chromosome autoimmune accelerator gene (Yaa), which accelerates disease in male mice. In these mice, we have shown that Bxs6 is sufficient to cause high-level expression of gp70 and the production of gp70 autoantibodies, independently of Yaa, with gp70 immune complex levels enhanced by Yaa. In the presence of Yaa, Bxs6 also causes mild nephritis, and interestingly the sporadic production of high levels of anti-DNA Abs in some mice. Fine mapping using rare recombinant mice suggested that Bxs6 lies between 59.7 and 74.8 megabases (Mb), although the interval of 0.6 Mb between 73.6 and 78.6 Mb on chromosome 13 cannot be excluded in this study.
authors: Rheumatology Section, Faculty of Medicine, Imperial College, Hammersmith Campus, Du Cane Road, London, UK.
authors: Joanna
authors: J
authors: Rankin
authors: Joseph J
authors: JJ
authors: Boyle
authors: S Jane
authors: SJ
authors: Rose
authors: Luisa
authors: L
authors: Gabriel
authors: Margarita
authors: M
authors: Lewis
authors: Vasuky
authors: V
authors: Thiruudaian
authors: Nicola J
authors: NJ
authors: Rogers
authors: Shozo
authors: S
authors: Izui
authors: Bernard J
authors: BJ
authors: Morley
mesh_terms: D000818:Animals; D000936:Antigen-Antibody Complex / Q000097:blood*; D001323:Autoantibodies / Q000097:blood / Q000235:genetics / Q000378:metabolism; D001324:Autoantigens / Q000097:blood / Q000276:immunology*; D001947:Breeding; D002875:Chromosomes / Q000235:genetics*; D006023:Glycoproteins / Q000097:blood / Q000276:immunology*; D008297:Male; D051379:Mice; D020297:Mice, Congenic; D009393:Nephritis / Q000235:genetics / Q000276:immunology; D020161:Physical Chromosome Mapping; D020641:Polymorphism, Single Nucleotide
chemical_list: D000936:Antigen-Antibody Complex; D001323:Autoantibodies; D001324:Autoantigens; D006023:Glycoproteins; C033589:glycoprotein gp70, murine serum