title: An outbreak of pulmonary tuberculosis in young Australians.
abstract: OBJECTIVE
  To characterise a pulmonary tuberculosis (TB) cluster in the Hunter Area of New South Wales using a combination of traditional epidemiological methods and molecular typing.
  
  
  METHODS
  Review of all notifications of TB in the Hunter Area between January 1994 and June 2005, with a detailed analysis of cases among people born in Australia or New Zealand.
  
  
  METHODS
  Comparison of genotypes of Mycobacterium tuberculosis isolates; extent of TB cluster.
  
  
  RESULTS
  Over the period studied, there were 72 TB notifications among people born in Australia or New Zealand. Genotypic testing was available for 20 of these cases, of which nine were confirmed to be part of a cluster. Two further cases for which genotyping was not available were epidemiologically linked to the cluster and regarded as probable cluster cases. Members of the cluster were relatively young (median age at diagnosis, 35 years; range, 21-57 years), and eight were women. Over the same period, there were 83 TB notifications among people born overseas, the majority being from Asia (47%) or central and eastern Europe (24%) (median age, 54 years; range, 9-63 years).
  
  
  CONCLUSIONS
  Clinicians should maintain a high index of suspicion for pulmonary TB in a person presenting with a productive cough lasting more than 3 weeks, weight loss, haemoptysis, night sweats and chest pain, even if the person is not overseas-born or elderly. A comprehensive tuberculosis genotyping network at regional and national level in Australia could help identify clusters resulting from recent transmission.
authors: Hunter New England Population Health, Newcastle, NSW, Australia. tony.merritt@hnehealth.nsw.gov.au
authors: Tony D
authors: TD
authors: Merritt
authors: Vitali
authors: V
authors: Sintchenko
authors: Peter
authors: P
authors: Jelfs
authors: Margaret
authors: M
authors: Worthing
authors: Brian
authors: B
authors: Robinson
authors: David N
authors: DN
authors: Durrheim
authors: Gwendolyn L
authors: GL
authors: Gilbert
mesh_terms: D000328:Adult; D016000:Cluster Analysis; D004196:Disease Outbreaks; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000235:genetics* / Q000302:isolation & purification; D009517:New South Wales / Q000453:epidemiology; D009520:New Zealand / Q000208:ethnology; D012150:Polymorphism, Restriction Fragment Length; D014397:Tuberculosis, Pulmonary / Q000453:epidemiology* / Q000235:genetics