title: Development of self-expandable covered stents.
abstract: We newly developed self-expandable covered stents by combining two of our original technologies. Of these, the first is the dip-coating covering method that was developed previously for balloon-expandable stents; the other is the newly developed self-expandable Nitinol stents, namely, Sendai stents. The three types of covered stents with the expansion diameter of 4.5, 5.0, or 6.0 mm thus obtained had a laser-processed microporous elastomeric cover film (pore diameter: 100 microm, interpore distance: 250 microm). Although the film was extremely thin (approximately 15 microm), the film could be expanded without causing any damage, the strut was completely embedded within the film, and the luminal surface of the film was smooth and flat. Mechanical properties such as ideal flexibility to follow the shapes of arteries were almost retained even after covering. As appropriate drugs, the blood-contacting inner and tissue-contacting outer surfaces of the film were differentially coated with argatroban for antithrombogenicity or FK506 for anti-inflammation, respectively. The preliminary in vivo study indicated that the covered stents mounted in the delivery catheter were navigated and placed to appropriate position in the arteries, and permissible neointimal thickening after 1-month implantation was observed similarly in noncovered stents.
authors: Department of Diagnostic Radiology, Graduate School of Medicine, Tohoku University, 1-1 Seiryo, Sendai, Miyagi 980-8574, Japan.
authors: Sachiko
authors: S
authors: Sato
authors: Yasuhide
authors: Y
authors: Nakayama
authors: Yoshihiro
authors: Y
authors: Miura
authors: Yoshihiro
authors: Y
authors: Okamoto
authors: Hiroyuki
authors: H
authors: Asano
authors: Hatsue
authors: H
authors: Ishibashi-Ueda
authors: Yue-Min
authors: YM
authors: Zhou
authors: Kyoko
authors: K
authors: Hayashida
authors: Toshio
authors: T
authors: Matsuhashi
authors: Kazumasa
authors: K
authors: Seiji
authors: Akihiro
authors: A
authors: Sato
authors: Takayuki
authors: T
authors: Yamada
authors: Shoki
authors: S
authors: Takahashi
authors: Tadashi
authors: T
authors: Ishibashi
mesh_terms: D000497:Alloys / Q000737:chemistry*; D000792:Angiography; D000818:Animals; D000925:Anticoagulants / Q000008:administration & dosage; D001120:Arginine / Q000031:analogs & derivatives; D001807:Blood Vessel Prosthesis; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D004285:Dogs; D004343:Drug Implants / Q000737:chemistry*; D004548:Elasticity; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D010875:Pipecolic Acids / Q000008:administration & dosage; D011474:Prosthesis Design; D015607:Stents; D013449:Sulfonamides; D016559:Tacrolimus / Q000008:administration & dosage
chemical_list: D000497:Alloys; D000925:Anticoagulants; D020099:Coated Materials, Biocompatible; D004343:Drug Implants; D007166:Immunosuppressive Agents; D010875:Pipecolic Acids; D013449:Sulfonamides; C013616:nitinol; D001120:Arginine; C031942:argatroban; D016559:Tacrolimus