Halogenated cyclic peptides isolated from the sponge Corticium sp.
Fractionation of two Fijian specimens of the sponge Corticium sp. led to the isolation of the known active alkaloid steroid plakinamine A and two new halogenated cyclic peptides, corticiamide A (1) and cyclocinamide B (2). Structural elucidation of 1 and 2 was achieved by an extensive combination of high-field NMR and HRFT MS/MS experiments, and the absolute stereochemistry of 2 was determined by acid hydrolysis and Marfey's analysis. Corticiamide A (1) and cyclocinamide B (2) represent the first peptides to be described from the genus Corticium.
Laird
Damian W
DW
Department of Medicinal Chemistry, University of Utah, Salt Lake City, Utah 84112, USA.
LaBarbera
Daniel V
DV
Feng
Xidong
X
Bugni
Tim S
TS
Harper
Mary Kay
MK
Ireland
Chris M
CM
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005367:Fiji; D006801:Humans; D006846:Hydrocarbons, Halogenated / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D011161:Porifera / Q000737:chemistry*
D000970:Antineoplastic Agents; D006846:Hydrocarbons, Halogenated; D010456:Peptides, Cyclic; C520801:corticiamide A; C520802:cyclocinamide B