title: Study of blood porphyrin spectral profile for diagnosis of tumor progression.
abstract: Renal cell carcinoma (RCC) accounts for approximately 3% of new cancer incidence and mortality in the United States. Unfortunately many RCC masses remain asymptomatic and nonpalpable until they are advanced. Diagnosis and localization of early carcinoma play an important role in the prevention and curative treatment of RCC. The autofluorescence of blood porphyrin of healthy and tumor induced in male SCID mice was analyzed using fluorescence and excitation spectroscopy. A significant contrast between normal and tumor blood could be established. Blood porphyrin fluorophore showed enhanced fluorescence band (around 630 nm) in function of the tumor growth. This indicates that either the autofluorescence intensity of the blood fluorescence may provide a good parameter for the "first approximation" characterization of the tumor stage.
authors: Departamento de Ciências Exatas, UNIFESP, Campus Diadema, Brazil. lcourrol@gmail.com
authors: Lilia Coronato
authors: LC
authors: Courrol
authors: Flávia Rodrigues
authors: FR
authors: de Oliveira Silva
authors: Enia Lúcia
authors: EL
authors: Coutinho
authors: Michelly França
authors: MF
authors: Piccoli
authors: Ronaldo Domingues
authors: RD
authors: Mansano
authors: Nilson Dias
authors: ND
authors: Vieira Júnior
authors: Nestor
authors: N
authors: Schor
authors: Maria Helena
authors: MH
authors: Bellini
mesh_terms: D000818:Animals; D002292:Carcinoma, Renal Cell / Q000097:blood / Q000175:diagnosis / Q000473:pathology; D045744:Cell Line, Tumor; D004195:Disease Models, Animal; D018450:Disease Progression; D006801:Humans; D008297:Male; D051379:Mice; D016513:Mice, SCID; D009367:Neoplasm Staging / Q000379:methods; D009369:Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000473:pathology; D011166:Porphyrins / Q000097:blood* / Q000737:chemistry; D011524:Protoporphyrins / Q000097:blood / Q000737:chemistry; D013050:Spectrometry, Fluorescence; D013056:Spectrophotometry, Ultraviolet
chemical_list: D011166:Porphyrins; D011524:Protoporphyrins; C028025:protoporphyrin IX