Redox regulation of cellular functions.
Maintenance of normal intracellular redox status plays an important role in such processes as DNA synthesis, gene expression, enzymatic activity, and others. In addition, it is clear that changes in the redox status of intracellular content and individual molecules, resulting from stress or intrinsic cellular activity, are involved in the regulation of different processes in cells. Small changes in intracellular levels of reactive oxygen species participate in intracellular signaling. Thiol-containing molecules, such as glutathione, thioredoxins, glutaredoxins, and peroxiredoxins, also play an important role in maintaining redox homeostasis and redox regulation. This review attempts to summarize the current knowledge about redox regulation in different cell types.
Oktyabrsky
O N
ON
Institute of Ecology and Genetics of Microorganisms, Urals Division of the Russian Academy of Sciences, 614081 Perm', Russia. oktyabr@iegm.ru
Smirnova
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GV
D015687:Cell Hypoxia; D002477:Cells / Q000378:metabolism*; D015964:Gene Expression Regulation, Bacterial; D015966:Gene Expression Regulation, Fungal; D054477:Glutaredoxins; D005978:Glutathione / Q000378:metabolism; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D010088:Oxidoreductases / Q000378:metabolism; D010100:Oxygen / Q000378:metabolism; D010544:Peroxidases / Q000378:metabolism; D054464:Peroxiredoxins; D017382:Reactive Oxygen Species / Q000378:metabolism*; D015398:Signal Transduction; D013879:Thioredoxins / Q000378:metabolism
D054477:Glutaredoxins; D017382:Reactive Oxygen Species; D013879:Thioredoxins; D010088:Oxidoreductases; D010544:Peroxidases; D054464:Peroxiredoxins; D005978:Glutathione; D010100:Oxygen