Role of class II phosphoinositide 3-kinase in cell signalling.
Although it is now well established that PI3K (phosphoinositide 3-kinase) is a key enzyme in several intracellular processes, there are still relatively few reports that precisely identify the specific isoforms of PI3K actually involved in such events. The lack of specific inhibitors has made it particularly difficult to address the physiological roles of some isoforms, such as the members of class II. As a consequence, there is still relatively little understanding of the role of these enzymes and the question about the intracellular role of these isoforms still waits for more answers.
Falasca
M
M
Centre for Cardiovascular Biology and Medicine, Division of Medicine, University College London, Rayne Building, London, UK. m.falasca@ucl.ac.uk
Maffucci
T
T
D000730:Androstadienes / Q000494:pharmacology; D000818:Animals; D002468:Cell Physiological Phenomena; D004789:Enzyme Activation; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006801:Humans; D007527:Isoenzymes / Q000378:metabolism; D008861:Microsomes / Q000201:enzymology; D019869:Phosphatidylinositol 3-Kinases / Q000145:classification / Q000378:metabolism*; D000081082:Phosphoinositide-3 Kinase Inhibitors; D010766:Phosphorylation; D015398:Signal Transduction / Q000502:physiology*; D000077191:Wortmannin
D000730:Androstadienes; D004791:Enzyme Inhibitors; D007527:Isoenzymes; D019869:Phosphatidylinositol 3-Kinases; D000081082:Phosphoinositide-3 Kinase Inhibitors; D000077191:Wortmannin