title: A reductase-mimicking thiourea organocatalyst incorporating a covalently bound NADH analogue: efficient 1,2-diketone reduction with in situ prosthetic group generation and recycling.
abstract: A new class of bifunctional organocatalyst promotes the chemoselective reduction of diketone electrophiles at catalytic loadings in the presence of an inorganic co-reductant.
authors: Centre for Synthesis and Chemical Biology, School of Chemistry, University of Dublin, Trinity College, Dublin 2, Ireland.
authors: Barbara
authors: B
authors: Procuranti
authors: Stephen J
authors: SJ
authors: Connon
mesh_terms: D002384:Catalysis; D007659:Ketones / Q000737:chemistry; D018716:Molecular Mimicry; D009243:NAD / Q000737:chemistry*; D010084:Oxidation-Reduction; D010088:Oxidoreductases / Q000737:chemistry*; D013890:Thiourea / Q000737:chemistry*
chemical_list: D007659:Ketones; D009243:NAD; D010088:Oxidoreductases; D013890:Thiourea