Preparation, characterization, and optimization of pancreas-targeted 5-Fu loaded magnetic bovine serum albumin microspheres.
The magnetic bovine serum albumin (BSA) microspheres (MS) were prepared by emulsification/solidification method. In this experiment, two kinds of magnetic MS, e.g. BSA MS and PEG-incorporated BSA microspheres (PMS) were prepared. The obtained MS were characterized by Malvern laser particle sizer and scanning electron microscopy (SEM). The obtained MS were spherical and about 1.3 microm in size. The magnetic responsivity and in vitro release behavior of these MS were studied in detail. The in vivo distribution and targeting delivery of 5-fluorouracil (5-Fu) magnetic MS after artery administration were studied in rat. The results showed that PMS could efficiently delivery 5-Fu to the targeted site compared with BSA MS without PEG MS and free drug.
Jia
Wen Juan
WJ
State Key Laboratory of Biotherapy, West China Medical School, West China Hospital, Sichuan University, Chengdu, 610041, People's Republic of China.
Liu
Jian Gang
JG
De Zhang
Yang
Y
Wang
Ji Wei
JW
Wang
Jun
J
Sun
Cheng Yi
CY
Pan
Yi Feng
YF
Yu
Chao
C
Li
Guo Zheng
GZ
Zhang
Heng
H
Gou
Ma Ling
ML
Tu
Ming Jing
MJ
Qian
Zhi Yong
ZY
D000818:Animals; D002417:Cattle; D002851:Chromatography, High Pressure Liquid; D005472:Fluorouracil / Q000008:administration & dosage*; D008280:Magnetics; D008863:Microspheres; D010179:Pancreas / Q000378:metabolism*; D012710:Serum Albumin, Bovine / Q000819:agonists*
D012710:Serum Albumin, Bovine; D005472:Fluorouracil