Interleukin-10 in the pathophysiology of inflammatory bowel disease: increased serum concentrations during the recovery phase.
Using a specific enzyme-linked immunosorbent assay, IL-10 concentrations were measured in serum from 62 patients with ulcerative colitis (UC), 43 with Crohn's disease (CD), 25 with other colitides, and 44 normal control subjects. Serum IL-10 concentrations were increased in patients with active UC but not in those with active CD when compared with normal control subjects. A time course study showed that in patients with UC and CD, serum concentrations of IL-6 and C-reactive protein increased during the acute phase and returned to normal as patients go into remission. Notably, serum IL-10 concentrations increased during the phase of disease resolution and declined thereafter regardless of the treatment modality. Gel filtration analysis indicated that IL-10 circulated predominantly as a dimer. In conclusion, this study shows that serum IL-10 is increased during disease recovery in patients with inflammatory bowel disease, and may be a helpful marker in monitoring disease status.
Mitsuyama
Keiichi
K
Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Japan.
Tomiyasu
Nobuo
N
Takaki
Kosuke
K
Masuda
Junya
J
Yamasaki
Hiroshi
H
Kuwaki
Kotaro
K
Takeda
Teiko
T
Kitazaki
Shigehiko
S
Tsuruta
Osamu
O
Sata
Michio
M
D000328:Adult; D002097:C-Reactive Protein / Q000032:analysis; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000097:blood* / Q000503:physiopathology*; D016753:Interleukin-10 / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D012016:Reference Values
D015850:Interleukin-6; D016753:Interleukin-10; D002097:C-Reactive Protein