title: Permissive and instructive anterior patterning rely on mRNA localization in the wasp embryo.
abstract: The long-germ mode of embryogenesis, in which segments arise simultaneously along the anteriorposterior axis, has evolved several times in different lineages of the holometabolous, or fully metamorphosing, insects. Drosophila's long-germ fate map is established largely by the activity of the dipteran-specific Bicoid (Bcd) morphogen gradient, which operates both instructively and permissively to accomplish anterior patterning. By contrast, all nondipteran long-germ insects must achieve anterior patterning independently of bcd. We show that bcd's permissive function is mimicked in the wasp by a maternal repression system in which anterior localization of the wasp ortholog of giant represses anterior expression of the trunk gap genes so that head and thorax can properly form.
authors: New York University, Department of Biology, Center for Developmental Genetics, 100 Washington Square East, New York, NY 10003, USA.
authors: Ava E
authors: AE
authors: Brent
authors: Gozde
authors: G
authors: Yucel
authors: Stephen
authors: S
authors: Small
authors: Claude
authors: C
authors: Desplan
mesh_terms: D000818:Animals; D019521:Body Patterning / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D004625:Embryo, Nonmammalian / Q000378:metabolism*; D047108:Embryonic Development; D018507:Gene Expression Regulation, Developmental; D017344:Genes, Insect; D006257:Head / Q000196:embryology; D019476:Insect Proteins / Q000235:genetics* / Q000378:metabolism; D051741:Kruppel-Like Transcription Factors / Q000235:genetics / Q000378:metabolism; D009024:Morphogenesis; D034622:RNA Interference; D023121:RNA, Messenger, Stored / Q000235:genetics / Q000378:metabolism*; D012097:Repressor Proteins / Q000235:genetics* / Q000378:metabolism; D013909:Thorax; D014863:Wasps / Q000196:embryology* / Q000235:genetics / Q000378:metabolism
chemical_list: D004268:DNA-Binding Proteins; D019476:Insect Proteins; D051741:Kruppel-Like Transcription Factors; D023121:RNA, Messenger, Stored; D012097:Repressor Proteins