Transition metal-catalyzed orthogonal solid-phase decoration of the 2(1H)-pyrazinone scaffold using a sulfur linker.
A new transition metal-catalyzed orthogonal solid-phase protocol for the synthesis of highly substituted 2(1H)-pyrazinones was developed, on the basis of Chan-Lam arylation and Liebeskind-Srogl cross-coupling reactions. This strategy opens the way for the generation of small libraries of 2(1H)-pyrazinone analogues for biological screening.
Kaval
Nadya
N
Laboratory for Organic & Microwave-Assisted Chemistry, Department of Chemistry, University of Leuven, Celestijnenlaan 200F, B-3001 Leuven, Belgium.
Singh
Brajendra Kumar
BK
Ermolat'ev
Denis S
DS
Claerhout
Stijn
S
Parmar
Virinder S
VS
der Eycken
Johan Van
JV
der Eycken
Erik Van
EV
D002384:Catalysis; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D015394:Molecular Structure; D011719:Pyrazines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D013438:Sulfhydryl Compounds / Q000737:chemistry*; D028561:Transition Elements / Q000737:chemistry*
D011719:Pyrazines; D013438:Sulfhydryl Compounds; D028561:Transition Elements