title: [Effects of microsatellite in the regulatory region of IGF1 on growth traits in Jinhua swine].
abstract: Insulin-like growth factor 1 (IGF1) and its associated binding proteins and transmembrane receptors (IGFR) play an important role in the physiologic process of mammalian growth. The objectives of present work were to estimate the effects of microsatellite markers located in the 5'-regulatory region of the IGF1 on birth weight (BW), weaning weight (WW), weight at the 120th day, the 180th day and litter weight at birth (LWB) by the least square method in Jinhua pig. Significant effect was found for IGF1 genotype on BW (P<0.05), with positive effects associated with the 286/286 genotype, and 280/286 genotype on LWB in second parity (P>0.05). Furthermore, according to analysis of allele average substitution effect, alleles 274 bp and 286 bp was favourable for BW increase, allele 280 bp was favourable for LWB increase in the second parity. By correlation analysis, total number of birth, number of birth alive and LWB of the second parity in Jinhua pig had highly significant correlation (P<0.01), therefore increasing LWB of the second parity could improve litter performance of Jinhua pig.
authors: College of Animal Science, Zhejiang University, Hangzhou, China. zxf79@sina.com
authors: Xiao-Feng
authors: XF
authors: Zhao
authors: Ning-Ying
authors: NY
authors: Xu
authors: Xiao-Xiang
authors: XX
authors: Hu
authors: Ning
authors: N
authors: Li
mesh_terms: D000818:Animals; D001835:Body Weight / Q000235:genetics; D007334:Insulin-Like Growth Factor I / Q000235:genetics*; D008098:Litter Size / Q000235:genetics; D018895:Microsatellite Repeats / Q000235:genetics*; D034421:Sus scrofa / Q000235:genetics*
chemical_list: D007334:Insulin-Like Growth Factor I