[Electron microscopical observation on rats with Pneumocystis carinii pneumonia treated with Brucea javanica and Fructus Psoraleae].
Rats with Pneumocystis carinii pneumonia (PCP) were established by hypodermic injection of dexamethasone and treated by Brucea javanica combined with Fructus Psoraleae 2 ml (Brucea javanica 0.12 mg and Fructus Psoraleae 1.0 mg) per rat per day for 7 days or 14 days. The effect of cyst-killing and the pathological change were observed under transmission electron microscope. Lung damage was alleviated or repaired, and a significant reduction of cysts was shown in the treatment group. The results show that a combination of Brucea javanica and Fructus Psoraleae played a significant restraining and killing effect on cysts, and helped repair the impairment of pneumonia.
Ren
Yi-Xin
YX
Department of Parasitology, Dalian Medical University, Dalian 116023, China.
Qin
Yuan-Hua
YH
Zheng
Li-Li
LL
Dai
Xiao-Dong
XD
Tao
Lin
L
Chen
Yu-Feng
YF
Cui
Yu
Y
D000818:Animals; D032269:Brucea / Q000737:chemistry*; D004195:Disease Models, Animal; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D008168:Lung / Q000187:drug effects / Q000473:pathology / Q000648:ultrastructure; D046529:Microscopy, Electron, Transmission; D008517:Phytotherapy; D011020:Pneumonia, Pneumocystis / Q000188:drug therapy* / Q000473:pathology; D029907:Psoralea / Q000737:chemistry*; D011650:Pulmonary Alveoli / Q000187:drug effects* / Q000473:pathology / Q000648:ultrastructure; D051381:Rats; D017207:Rats, Sprague-Dawley
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal