The effect of zoledronate on bone remodeling during the healing process.
OBJECTIVE
To check the effect of zoledronate in bone remodeling during bone healing.


METHODS
Thirty rabbits were divided into two groups of fifteen animals each (control and experimental group respectively). Shaft osteotomy was performed on the cranial portion of the fibula of each animal. In the experimental group, a single dose of 0.04mg/kg of zoledronate was administered. In the control group, the same volume of bi-distilled water was administered. After one, two and four weeks, animals of both groups were killed and histological sections of the fibular metaphyseal area were examined histomorphometrically. The parameters analyzed were tissue volume (TV), fractional trabecular bone volume (BV/TV) and fractional medullary fibrous volume (FbV/TV).


RESULTS
Tissue volume increased in the experimental group (237.2mm(2).10-2) compared to the control (166.62mm(2).10-2). Trabecular bone volume was significantly larger in the experimental (60.2%) than in the control group (34.8%). The amount of fibrosis volume decreased in the experimental group (22%) compared to the control (49.4%).


CONCLUSIONS
The effect of zoledronate is characterized by accentuated stimulus of bone formation in the metaphyseal area, resulting in a larger amount of trabecular bone volume and little fibrosis volume.
Matos
Marcos Almeida
MA
Division of Orthopedics and Traumatology, Department of Surgery, Bahia School of Medicine and Public Health, Salvador, Brazil. malmeidamatos@ig.com.br
Araújo
Francisco Pereira
FP
Paixão
Fábio Brasileiro
FB
D000818:Animals; D050071:Bone Density Conservation Agents / Q000494:pharmacology*; D016723:Bone Remodeling / Q000187:drug effects*; D004164:Diphosphonates / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D017102:Fracture Healing / Q000187:drug effects*; D007093:Imidazoles / Q000494:pharmacology*; D008297:Male; D010027:Osteotomy / Q000379:methods*; D011817:Rabbits; D018709:Statistics, Nonparametric; D000077211:Zoledronic Acid
D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D007093:Imidazoles; D000077211:Zoledronic Acid