title: A new cytotoxic lanostane-type triterpene glycoside from the sea cucumber Holothuria impatiens.
abstract: A new lanostane-type triterpene glycoside, impatienside A (1), was isolated from the sea cucumber Holothuria impatiens, together with a structurally related, known compound, bivittoside D (2). Their structures were elucidated by in-depth spectroscopic and mass-spectrometric methods, including (1)H-, (13)C-, and 2D-NMR, ESI-MS, and HR-ESI-MS experiments, as well as by chemical evidence. Compounds 1 and 2 possess the same hexasaccharide moieties, but differ slightly in their holostane-type triterpene aglycone. The two glycosides were found to exhibit in vitro cytotoxicities similar to or better than those of the potent anticancer drug etoposide (V-16) against seven different human tumor cells, with IC50 values of 0.37-2.75 microg/ml.
authors: Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, PR. China.
authors: Peng
authors: P
authors: Sun
authors: Bao-Shu
authors: BS
authors: Liu
authors: Yang-Hua
authors: YH
authors: Yi
authors: Ling
authors: L
authors: Li
authors: Min
authors: M
authors: Gui
authors: Hai-Feng
authors: HF
authors: Tang
authors: Da-Zhi
authors: DZ
authors: Zhang
authors: Shi-Long
authors: SL
authors: Zhang
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification; D045744:Cell Line, Tumor; D003603:Cytotoxins / Q000737:chemistry / Q000302:isolation & purification*; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification*; D047332:Holothuria; D006801:Humans; D012616:Sea Cucumbers; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D000970:Antineoplastic Agents; D003603:Cytotoxins; D006027:Glycosides; D014315:Triterpenes