Localized biosensing with Topas microstructured polymer optical fiber.
We present what is believed to be the first microstructured polymer optical fiber (mPOF) fabricated from Topas cyclic olefin copolymer, which has attractive material and biochemical properties. This polymer allows for a novel type of fiber-optic biosensor, where localized sensor layers may be activated on the inner side of the air holes in a predetermined section of the mPOF. The concept is demonstrated using a fluorescence-based method for selective detection of fluorophore-labeled antibodies.
Emiliyanov
Grigoriy
G
COM - DTU, Department of Communications, Optics and Materials, Technical University of Denmark, Muilding 345v, 2800 Kgs. Lyngby, Denmark. gem@com.dtu.dk
Jensen
Jesper B
JB
Bang
Ole
O
Hoiby
Poul E
PE
Pedersen
Lars H
LH
Kjaer
Erik M
EM
Lindvold
Lars
L
D000475:Alkenes / Q000737:chemistry; D001672:Biocompatible Materials / Q000737:chemistry; D015374:Biosensing Techniques; D002097:C-Reactive Protein / Q000737:chemistry; D002232:Carbocyanines / Q000737:chemistry; D005336:Fiber Optic Technology; D008856:Microscopy, Fluorescence / Q000295:instrumentation / Q000379:methods; D055100:Optical Fibers; D055095:Optics and Photonics; D011108:Polymers / Q000737:chemistry*; D019904:Polymethyl Methacrylate / Q000737:chemistry; D019809:Streptavidin / Q000737:chemistry; D014466:Ultraviolet Rays
D000475:Alkenes; D001672:Biocompatible Materials; D002232:Carbocyanines; D011108:Polymers; C089187:cyanine dye 3; D002097:C-Reactive Protein; D019904:Polymethyl Methacrylate; D019809:Streptavidin