Liposomes and niosomes as potential carriers for dermal delivery of minoxidil.
The aim of this work was to formulate minoxidil loaded liposome and niosome formulations to improve skin drug delivery. Multilamellar liposomes were prepared using soy phosphatidylcholine at different purity degrees (Phospholipon 90, 90% purity, soy lecithin (SL), 75% purity) and cholesterol (Chol), whereas niosomes were made with two different commercial mixtures of alkylpolyglucoside (APG) surfactants (Oramix NS10, Oramix CG110), Chol and dicetylphosphate. Minoxidil skin penetration and permeation experiments were performed in vitro using vertical diffusion Franz cells and human skin treated with either drug vesicular systems or propylene glycol-water-ethanol solution (control). Penetration of minoxidil in epidermal and dermal layers was greater with liposomes than with niosomal formulations and the control solution. These differences might be attributed to the smaller size and the greater potential targeting to skin and skin appendages of liposomal carriers, which enhanced globally the skin drug delivery. The greatest skin accumulation was always obtained with non-dialysed vesicular formulations. No permeation of minoxidil through the whole skin thickness was detected in the present study irrespective of the existence of hair follicles. Alcohol-free liposomal formulations would constitute a promising approach for the topical delivery of minoxidil in hair loss treatment.
Mura
Simona
S
Laboratoire de Recherche et Développement de Pharmacie Galénique Industrielle, Institut des Sciences Pharmaceutiques et Biologiques, Université Claude Bernard Lyon, France. somipika@libero.it
Pirot
Fabrice
F
Manconi
Maria
M
Falson
Françoise
F
Fadda
Anna M
AM
D000959:Antihypertensive Agents / Q000008:administration & dosage*; D004337:Drug Carriers; D006801:Humans; D008081:Liposomes; D008854:Microscopy, Electron; D008914:Minoxidil / Q000008:administration & dosage*
D000959:Antihypertensive Agents; D004337:Drug Carriers; D008081:Liposomes; D008914:Minoxidil