Low-dose oral tri-iodothyronine does not directly increase food intake in man.
Previously, we have shown that low-dose tri-iodothyronine (T3) increases food intake in rodents. This randomised, double-blind, placebo-controlled study aimed to investigate the effects of low-dose T3 on food intake in normal body weight individuals. However, despite an elevation in fT3 comparable to our earlier studies, administration of low-dose T3 in the fasted state did not stimulate food intake in man.
Martin
N M
NM
Department of Metabolic Medicine, Hammersmith Hospital, Imperial College London, London, UK.
Small
C J
CJ
Lee
J L
JL
Ellis
S
S
Dhillo
W S
WS
Smith
K L
KL
Kong
W M
WM
Frost
G S
GS
Bloom
S R
SR
D000284:Administration, Oral; D000328:Adult; D018592:Cross-Over Studies; D004311:Double-Blind Method; D004435:Eating / Q000187:drug effects* / Q000502:physiology; D002149:Energy Intake / Q000502:physiology; D004734:Energy Metabolism / Q000502:physiology; D006801:Humans; D008297:Male; D013972:Thyrotropin / Q000097:blood; D014284:Triiodothyronine / Q000008:administration & dosage* / Q000097:blood
D014284:Triiodothyronine; D013972:Thyrotropin