title: Low serum high-density lipoprotein cholesterol in obese subjects with normal serum triglycerides: the role of insulin resistance and inflammatory cytokines.
abstract: BACKGROUND
  The cause of obesity-related low HDLc in the absence of hypertriglyceridemia is not known.
  
  
  METHODS
  A total of 32 subjects with a body mass index (BMI)(kg/m(2)) greater than 30 and normal serum triglycerides (<150 mg/dl) were identified.
  
  
  RESULTS
  People with low HDLc (n = 16) compared to those with normal HDLc (n = 16) had higher BMI (37.53 +/- 4.54 vs. 33.99 +/- 3.65 kg/m(2), p < 0.021), higher body fat weight (42.59 +/- 9.51 vs. 34.76 +/- 8.7 kg, p < 0.023), and higher insulin resistance index (3.75 +/- 2.51 vs. 1.95 +/- 1.10, p < 0.013). Seven subjects with low HDLc and none of those with normal HDLc, had elevated serum tumor necrosis factor alpha and/or interleukin-6 (p < 0.010).
  
  
  CONCLUSIONS
  Low HDLc levels can occur in obesity independently of elevated serum triglycerides and may be secondary to elevated serum levels of inflammatory cytokines.
authors: Department of Internal Medicine, Division of Endocrinology, Diabetes and Metabolism, Saint Louis University School of Medicine, Saint Louis, MO 63104, USA. mooradad@slu.edu
authors: A D
authors: AD
authors: Mooradian
authors: S G
authors: SG
authors: Albert
authors: M J
authors: MJ
authors: Haas
mesh_terms: D000273:Adipose Tissue / Q000503:physiopathology; D000328:Adult; D015992:Body Mass Index; D008076:Cholesterol, HDL / Q000097:blood*; D016207:Cytokines / Q000097:blood*; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D009765:Obesity / Q000097:blood*; D014280:Triglycerides / Q000097:blood*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D008076:Cholesterol, HDL; D016207:Cytokines; D015850:Interleukin-6; D014280:Triglycerides; D014409:Tumor Necrosis Factor-alpha