title: Mucinous cystadenocarcinoma of the pancreas developing during hormone replacement therapy.
abstract: Hormone replacement therapy (HRT) containing estrogens is generally used to relieve climacteric symptoms and to prevent osteoporosis and coronary heart disease [1], however, there has been increasing evidence of the HRT as the risk of hormone-dependent neoplasms including breast cancer [2], uterine endometrial cancer [3], ovarian cancer [4], and even lung cancer [5]. Noteworthy is mucinous cyst neoplasms (MCNs) of the pancreas, characterized by mucin-producing columnar epithelium supported by "ovarian-like" mesenchymal stroma, occur mostly in females expressing estrogen receptors [6, 7]. Although several reports regarding the closed relationship between MCNs and pregnancy [8, 9] might imply potential sex hormone-dependency of the MCNs [10], no correlation has been reported. This is the first case report of malignant MCN developing during continuous HRT after hysterectomy.
authors: Department of Hepato-Biliary-Pancreatic Surgery, Tokyo Medical and Dental University, Graduate School of Medicine, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan. shinji.msrg@tmd.ac.jp
authors: Shinji
authors: S
authors: Tanaka
authors: Toru
authors: T
authors: Kawamura
authors: Noriaki
authors: N
authors: Nakamura
authors: Kenichi
authors: K
authors: Teramoto
authors: Shigeki
authors: S
authors: Arii
mesh_terms: D018282:Cystadenocarcinoma, Mucinous / Q000139:chemically induced* / Q000737:chemistry / Q000473:pathology / Q000601:surgery; D015914:Estrogen Replacement Therapy / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007044:Hysterectomy; D007265:Inhibins / Q000032:analysis; D008875:Middle Aged; D009376:Neoplasms, Hormone-Dependent / Q000139:chemically induced* / Q000737:chemistry / Q000473:pathology / Q000601:surgery; D010180:Pancreatectomy; D010190:Pancreatic Neoplasms / Q000139:chemically induced* / Q000737:chemistry / Q000473:pathology / Q000601:surgery; D011960:Receptors, Estrogen / Q000032:analysis; D011980:Receptors, Progesterone / Q000032:analysis; D013156:Splenectomy; D017154:Stromal Cells / Q000737:chemistry / Q000187:drug effects* / Q000473:pathology; D016896:Treatment Outcome; D014463:Ultrasonography / Q000379:methods
chemical_list: D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D007265:Inhibins