[The influence of some retarding agents NOS of dihydrothiazine-thiazoline rank on postradiational of recovery endogenous CFU-S-8 of mice].
In this work the attempt to estimate a nitric oxide (NO*) role in regulation of the number of pool haemopoietic stem cells at the irradiated mice was made. With this purpose the number of new compounds from dihydrothiazine-thiazoline line was synthesized, their NO-inhibiting activity was investigated in vivo by the method of ESR-spectroscopy of spin trap and their influence on an output endogenous spleen colonies (CFU-S-8) after the total sublethal y-irradiation of mice in a doze of 6 Gy was also investigated. Was shown, that the tested compounds reduced the contents of NO* in a liver tissue of mice which have received an injection of nitric oxide synthesis inductor - lipopolysaccharide, and also increased an output CFU-S-8 forming endogenous colonies in the spleen of the irradiated mice. Received data testify to perceptivity of search radioprotective agents among NO* synthesis inhibitors.
Konopliannikov
A G
AG
Proskuriakov
S Ia
SIa
Konopliannikov
O A
OA
Trishkina
A I
AI
Shteĭn
L V
LV
Verkhovskiĭ
Iu G
IuG
Kolesnikova
A I
AI
Trofimova
T P
TP
Mandrugin
A A
AA
Fedoseev
V M
VM
Bachurin
S O
SO
Proshin
A N
AN
Skvortsov
V G
VG
D000818:Animals; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D015672:Erythroid Precursor Cells / Q000187:drug effects* / Q000201:enzymology / Q000528:radiation effects; D008099:Liver / Q000737:chemistry; D008297:Male; D051379:Mice; D009569:Nitric Oxide / Q000032:analysis; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors*; D011837:Radiation-Protective Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013154:Spleen / Q000166:cytology / Q000528:radiation effects; D013843:Thiazines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013844:Thiazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
D004791:Enzyme Inhibitors; D011837:Radiation-Protective Agents; D013843:Thiazines; D013844:Thiazoles; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase