Preceding infections and anti-ganglioside antibodies in patients with Guillain-Barré syndrome: a single centre prospective case-control study.
Preceding infections and anti-ganglioside antibodies were assessed among 80 Guillain-Barré syndrome (GBS) patients and 125 controls. Previous infections were more frequent among GBS patients than among controls (p <0.0001), and had a significant association with axonal subtype compared with acute inflammatory demyelinating polyneuropathy (AIDP) (29/46 vs. 10/34 patients; p <0.05). Campylobacter jejuni (26%) was the most common preceding infection among GBS patients, followed by Mycoplasma pneumoniae (15%). Anti-ganglioside antibodies were detected more frequently among GBS patients than among controls (65/80 vs. 13/125; p <0.001), and a higher proportion of axonal cases had these antibodies than did AIDP patients (43/46 vs. 22/34; p <0.01).
Sinha
S
S
Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.
Prasad
K N
KN
Jain
D
D
Pandey
C M
CM
Jha
S
S
Pradhan
S
S
D000328:Adult; D000906:Antibodies / Q000097:blood*; D001369:Axons / Q000473:pathology; D001424:Bacterial Infections / Q000150:complications*; D002169:Campylobacter Infections / Q000150:complications; D016123:Campylobacter jejuni; D016022:Case-Control Studies; D005260:Female; D005732:Gangliosides / Q000276:immunology*; D020275:Guillain-Barre Syndrome / Q000209:etiology* / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D008297:Male; D008875:Middle Aged; D011019:Pneumonia, Mycoplasma / Q000150:complications; D011446:Prospective Studies
D000906:Antibodies; D005732:Gangliosides; D007074:Immunoglobulin G; D007075:Immunoglobulin M