title: Inhibitory effects of histone deacetylase inhibitor depsipeptide on benzo(a)pyrene- and cyclophosphamide-induced genotoxicity in Swiss albino mice.
abstract: Depsipeptide (FK228 or FR901228) was evaluated in the mouse bone marrow micronucleus test for its possible protective effect against chromosomal damage induced by benzo(a)pyrene and cyclophosphamide. Three doses of depsipeptide (0.5, 1, and 1.5 mg/kg body weight) were given intravenously to mice for 7 consecutive days prior to administration of genotoxins under investigation. All the three doses of depsipeptide were effective in exerting a protective effect against both benzo(a)pyrene and cyclophosphamide. A significant suppression (34.9% to 67.5%) in the micronuclei formation induced by benzo(a)pyrene and (25.7% to 71.5%) cyclophosphamide was observed following intravenous administration of depsipeptide at doses of 0.5, 1, and 1.5 mg/kg in Swiss albino mice.
authors: Department of Biochemistry, University of Madras, Guindy Campus, Chennai, India.
authors: Vinodhkumar
authors: V
authors: Radhakrishnan
authors: Radhakrishnan
authors: R
authors: Vinodhkumar
authors: Radhakrishnan Vinodh
authors: RV
authors: Kumar
authors: Chung Mu
authors: CM
authors: Park
authors: Park Chung
authors: PC
authors: Mu
authors: Vilwanathan
authors: V
authors: Ravikumar
authors: Thiruvengadam
authors: T
authors: Devaki
mesh_terms: D000818:Animals; D016587:Antimutagenic Agents / Q000494:pharmacology*; D001564:Benzo(a)pyrene; D002861:Chromobacterium / Q000737:chemistry; D003520:Cyclophosphamide; D004249:DNA Damage; D047630:Depsipeptides / Q000494:pharmacology*; D056572:Histone Deacetylase Inhibitors; D008297:Male; D051379:Mice; D015162:Micronucleus Tests
chemical_list: D016587:Antimutagenic Agents; D047630:Depsipeptides; D056572:Histone Deacetylase Inhibitors; D001564:Benzo(a)pyrene; D003520:Cyclophosphamide