A strong association between human earwax-type and apocrine colostrum secretion from the mammary gland.
Here we provided the first genetic evidence for an association between the degree of apocrine colostrum secretion and human earwax type. Genotyping at the earwax-type locus, rs17822931 within the ABCC11 gene, revealed that 155 of 225 Japanese women were dry-type and 70 wet-type. Frequency of women without colostrum among dry-type women was significantly higher than that among wet-type women (P<0.0002), and the measurable colostrum volume in dry-type women was significantly smaller than in wet-type women (P=0.0341).
Miura
Kiyonori
K
Department of Obstetrics and Gynaecology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan. kiyonori@nagasaki-u.ac.jp
Yoshiura
Koh-ichiro
K
Miura
Shoko
S
Shimada
Takako
T
Yamasaki
Kentaro
K
Yoshida
Atsushi
A
Nakayama
Daisuke
D
Shibata
Yoshisada
Y
Niikawa
Norio
N
Masuzaki
Hideaki
H
D018528:ATP-Binding Cassette Transporters / Q000235:genetics; D044466:Asian People; D002571:Cerumen / Q000378:metabolism*; D003126:Colostrum / Q000378:metabolism*; D005260:Female; D006801:Humans; D011110:Polymorphism, Genetic
C435500:ABCC11 protein, human; D018528:ATP-Binding Cassette Transporters