Brain activation in elderly people with and without dementia: Influences of gender and medication.
Patients suffering from dementia show altered functional brain activation patterns especially in prefrontal brain regions, as research suggests. The present study follows three aims: to replicate these findings, to investigate treatment effects when administering galantamine, and to put gender differences in focus. We compared 12 patients with dementia to 12 age- and gender-matched healthy subjects regarding changes in haemoglobin concentration in brain tissue while performing a verbal fluency task (VFT). Concentration changes of oxygenated (O(2)Hb) and deoxygenated (HHb) haemoglobin were measured by multi-channel near-infrared spectroscopy (NIRS), an easily applicable and non-invasive method of optical topography. In the patient group, measurement was repeated 4 and 8 weeks after starting treatment with galantamine. The results showed a reduced increase in O(2)Hb during task performance for patients compared to healthy controls. Furthermore, female subjects showed more pronounced activation in O(2)Hb as well as HHb compared to male subjects. Regarding treatment effects, no clear results could be obtained. In HHb, evidence for an entrainment effect was found. In the light of existing literature, the present study suggests an interaction of gender and age regarding brain activation patterns which should be aimed at in future investigations.
Richter
Melany M
MM
Laboratory of Psychophysiology and Functional Imaging, University Hospital of Psychiatry and Psychotherapy, Wuerzburg, Germany. Richter_M1@klinik.uni-wuerzburg.de
Herrmann
Martin J
MJ
Ehlis
Ann-Christine
AC
Plichta
Michael M
MM
Fallgatter
Andreas J
AJ
D000368:Aged; D000544:Alzheimer Disease / Q000188:drug therapy* / Q000503:physiopathology; D001143:Arousal / Q000187:drug effects* / Q000502:physiology; D001921:Brain / Q000187:drug effects* / Q000503:physiopathology; D005260:Female; D005702:Galantamine / Q000627:therapeutic use*; D006441:Hemoglobin A / Q000378:metabolism; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D008297:Male; D011939:Mental Recall / Q000187:drug effects; D009483:Neuropsychological Tests; D018697:Nootropic Agents / Q000627:therapeutic use*; D010108:Oxyhemoglobins / Q000378:metabolism; D017397:Prefrontal Cortex / Q000187:drug effects* / Q000503:physiopathology; D012016:Reference Values; D012737:Sex Factors; D019265:Spectroscopy, Near-Infrared; D013850:Thinking / Q000187:drug effects; D014705:Verbal Behavior / Q000187:drug effects; D014825:Vocabulary
D006454:Hemoglobins; D018697:Nootropic Agents; D010108:Oxyhemoglobins; D005702:Galantamine; C100003:deoxyhemoglobin; D006441:Hemoglobin A