title: Feasibility of a low-fat/high-fiber diet intervention with soy supplementation in prostate cancer patients after prostatectomy.
abstract: OBJECTIVE
  To evaluate the feasibility and long-term compliance with a low-fat diet supplemented with soy protein in men at increased risk for recurrence after radical prostatectomy.
  
  
  METHODS
  Randomized, control study.
  
  
  METHODS
  Academic center in USA.
  
  
  METHODS
  Forty men who had undergone radical prostatectomy and were at increased risk for recurrence.
  
  
  METHODS
  Low-fat (15% fat), high-fiber (18 g/1000 kcal) diet supplemented with 40 g soy protein isolate (n=26) was compared to USDA recommended diet (n=14).
  
  
  RESULTS
  Over 4 years, subjects in the intervention group but not in the control group made and sustained significant changes in their diet as measured by the dietary assessment instruments and urinary isoflavone excretion. In the intervention group, dietary fat intake was reduced from 33.46+/-1.27% energy/day to 21.04+/-1.74% (P<0.05), fiber intake increased from 14.6+/-1.06 to 21.05+/-2.29 g/day. The insulin growth factor-1 (IGF-1) level was decreased from 260.4+/-8.6 ng/ml at baseline to 220.5+/-7.9 ng/ml at 6 months (P<0.05) in the intervention group with no significant change in the control group. An ex vivo assay demonstrated inhibition of LNCaP cell growth (-20.0+/-7.7%, P<0.05) by sera from patients in the intervention group after 6 months of dietary change compared to baseline.
  
  
  CONCLUSIONS
  These data suggest that long-term low-fat dietary interventions as part of prospective randomized trials in prostate cancer survivors are feasible, and lead to reductions in circulating hormones or other growth factors stimulating prostate cancer growth ex vivo.
authors: Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, CA, USA. zli@mednet.ucla.edu
authors: Z
authors: Z
authors: Li
authors: W J
authors: WJ
authors: Aronson
authors: J R
authors: JR
authors: Arteaga
authors: K
authors: K
authors: Hong
authors: G
authors: G
authors: Thames
authors: S M
authors: SM
authors: Henning
authors: W
authors: W
authors: Liu
authors: R
authors: R
authors: Elashoff
authors: J M
authors: JM
authors: Ashley
authors: D
authors: D
authors: Heber
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000652:urine; D018752:Diet, Fat-Restricted; D004041:Dietary Fats / Q000008:administration & dosage* / Q000009:adverse effects; D004043:Dietary Fiber / Q000008:administration & dosage*; D019587:Dietary Supplements; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D007529:Isoflavones / Q000652:urine; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000178:diet therapy / Q000453:epidemiology / Q000601:surgery*; D030262:Soybean Proteins / Q000008:administration & dosage*
chemical_list: D015415:Biomarkers; D004041:Dietary Fats; D004043:Dietary Fiber; D007529:Isoflavones; D030262:Soybean Proteins; D007334:Insulin-Like Growth Factor I