[Vascular endothelial growth factor-C (VEGF-C) and vascular endothelial growth factor-D (VEGF-D) in ovarian carcinomas].
OBJECTIVE
The aim of the work was to assess vascular endothelial growth factor VEGF-C and vascular endothelial growth factor VEGF-D expression in ovarian carcinomas.


METHODS
Clinical records and preserved specimens from 80 patients with ovarian cacinoma who underwent treatment at Lower Silesia Centre of Oncology were examined consecutively.


RESULTS
Most of analysed patients (n=53) had serous adenocarcinomas at III or IV FIGO stage. The median VEGF-C expression analysed semiquantitively using immunohistochemistry method was 3.84, and in 5% of cases expression of marker was not found. Also median VEGF-D expression was 3.71, and reactivity of this cytokine was not found in 16.25% of cases. There was strong correlation between expression of VEGF-C and VEGF-D. Conversely, there was no significant correlation between VEGF-C and VEGF-D expression and clinicopathological features of ovarian carcinoma. Univariate analysis demonstrated that high expression of cytokines wasn't associated with worse survival rate.


CONCLUSIONS
This incresistence indicated that studies on angiogenesis in ovarian carcinomas should be continued.
Rossochacka-Rostalska
Barbara
B
Katedra Onkologii i Klinika Onkologii Ginekologicznej Akademii Medycznej we Wrocławiu.
Gisterek
Iwona
I
Suder
Elzbieta
E
Matkowski
Rafał
R
Szelachowska
Jolanta
J
Kornafel
Jan
J
D000328:Adult; D014408:Biomarkers, Tumor / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000378:metabolism* / Q000473:pathology*; D011044:Poland; D012189:Retrospective Studies; D016019:Survival Analysis; D042582:Vascular Endothelial Growth Factor C / Q000378:metabolism*; D042643:Vascular Endothelial Growth Factor D / Q000378:metabolism*
D014408:Biomarkers, Tumor; D042582:Vascular Endothelial Growth Factor C; D042643:Vascular Endothelial Growth Factor D