title: The 15-Country Collaborative Study of Cancer Risk among Radiation Workers in the Nuclear Industry: estimates of radiation-related cancer risks.
abstract: A 15-Country collaborative cohort study was conducted to provide direct estimates of cancer risk following protracted low doses of ionizing radiation. Analyses included 407,391 nuclear industry workers monitored individually for external radiation and 5.2 million person-years of follow-up. A significant association was seen between radiation dose and all-cause mortality [excess relative risk (ERR) 0.42 per Sv, 90% CI 0.07, 0.79; 18,993 deaths]. This was mainly attributable to a dose-related increase in all cancer mortality (ERR/Sv 0.97, 90% CI 0.28, 1.77; 5233 deaths). Among 31 specific types of malignancies studied, a significant association was found for lung cancer (ERR/Sv 1.86, 90% CI 0.49, 3.63; 1457 deaths) and a borderline significant (P = 0.06) association for multiple myeloma (ERR/Sv 6.15, 90% CI <0, 20.6; 83 deaths) and ill-defined and secondary cancers (ERR/Sv 1.96, 90% CI -0.26, 5.90; 328 deaths). Stratification on duration of employment had a large effect on the ERR/Sv, reflecting a strong healthy worker survivor effect in these cohorts. This is the largest analytical epidemiological study of the effects of low-dose protracted exposures to ionizing radiation to date. Further studies will be important to better assess the role of tobacco and other occupational exposures in our risk estimates.
authors: International Agency for Research on Cancer, Lyon, France.
authors: E
authors: E
authors: Cardis
authors: M
authors: M
authors: Vrijheid
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authors: M
authors: Blettner
authors: E
authors: E
authors: Gilbert
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authors: M
authors: Hakama
authors: C
authors: C
authors: Hill
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authors: Howe
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authors: J
authors: Kaldor
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authors: CR
authors: Muirhead
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authors: M
authors: Schubauer-Berigan
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authors: T
authors: Yoshimura
authors: F
authors: F
authors: Bermann
authors: G
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authors: Cowper
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authors: J
authors: Fix
authors: C
authors: C
authors: Hacker
authors: B
authors: B
authors: Heinmiller
authors: M
authors: M
authors: Marshall
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authors: Thierry-Chef
authors: D
authors: D
authors: Utterback
authors: Y-O
authors: YO
authors: Ahn
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authors: Amoros
authors: P
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authors: Ashmore
authors: A
authors: A
authors: Auvinen
authors: J-M
authors: JM
authors: Bae
authors: J
authors: J
authors: Bernar
authors: A
authors: A
authors: Biau
authors: E
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authors: Combalot
authors: P
authors: P
authors: Deboodt
authors: A
authors: A
authors: Diez Sacristan
authors: M
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authors: Eklöf
authors: H
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authors: Engels
authors: G
authors: G
authors: Engholm
authors: G
authors: G
authors: Gulis
authors: R R
authors: RR
authors: Habib
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authors: Holan
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authors: Hyvonen
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authors: Kerekes
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authors: Kurtinaitis
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authors: H
authors: Malker
authors: M
authors: M
authors: Martuzzi
authors: A
authors: A
authors: Mastauskas
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authors: A
authors: Monnet
authors: M
authors: M
authors: Moser
authors: M S
authors: MS
authors: Pearce
authors: D B
authors: DB
authors: Richardson
authors: F
authors: F
authors: Rodriguez-Artalejo
authors: A
authors: A
authors: Rogel
authors: H
authors: H
authors: Tardy
authors: M
authors: M
authors: Telle-Lamberton
authors: I
authors: I
authors: Turai
authors: M
authors: M
authors: Usel
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authors: Veress
mesh_terms: D000328:Adult; D015331:Cohort Studies; D004651:Employment / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D007221:Industry / Q000706:statistics & numerical data*; D007391:International Cooperation; D008297:Male; D009381:Neoplasms, Radiation-Induced / Q000401:mortality*; D009688:Nuclear Reactors / Q000706:statistics & numerical data*; D009784:Occupational Diseases / Q000401:mortality*; D016273:Occupational Exposure / Q000706:statistics & numerical data*; D011829:Radiation Dosage; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D016019:Survival Analysis; D015996:Survival Rate; D014915:Whole-Body Counting / Q000706:statistics & numerical data*