title: A case report of the therapeutic effect of cryofiltration in a patient with glucocorticoid-resistant ulcerative colitis.
abstract: Ulcerative colitis (UC) is characterized by chronic inflammation of the colon and its cause and pathogenesis have not been fully clarified. Although UC is treated with various drugs, including 5-amino-salycilate and glucocorticoids, some patients are resistant to them. It was recently reported that apheresis, such as leukocytapheresis and granulocytapheresis, improves intestinal inflammation in refractory cases of UC. On the other hand, cryofiltration, in which plasma apheresis is used to remove immunoglobulin and immune complexes, has been used for the treatment of autoimmune diseases. We herein report a case of glucocorticoid-resistant UC successfully treated with cryofiltration. Interestingly, the level of interleukin-10 (IL-10) in the patient's serum was markedly increased after eight sessions of cryofiltration. This suggests that cryofiltration suppresses intestinal inflammation, in part via up-regulation of IL-10.
authors: Department of Gastroenterology, Sapporo Hokuyu Hospital, Hokkaido University Graduate School of Medicine, Sapporo, Japan. tokawara@med.hokudai.ac.jp
authors: Tatsuya
authors: T
authors: Ohkawara
authors: Masao
authors: M
authors: Saito
authors: Souichi
authors: S
authors: Nakagawa
authors: Hiroko
authors: H
authors: Ohizumi
authors: Toru
authors: T
authors: Tamaki
authors: Motoki
authors: M
authors: Yonekawa
authors: Hiroshi
authors: H
authors: Takeda
authors: Masahiro
authors: M
authors: Asaka
authors: Jun
authors: J
authors: Nishihira
authors: Akio
authors: A
authors: Kawamura
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D000328:Adult; D000936:Antigen-Antibody Complex / Q000097:blood; D003093:Colitis, Ulcerative / Q000097:blood / Q000276:immunology / Q000628:therapy*; D017679:Cryotherapy; D004351:Drug Resistance; D005260:Female; D005374:Filtration; D006801:Humans; D007136:Immunoglobulins / Q000097:blood; D016753:Interleukin-10 / Q000097:blood; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones; D000936:Antigen-Antibody Complex; D007136:Immunoglobulins; D016753:Interleukin-10