[Characterization of Schizosaccharomyces pombe secreted proteins].
Secreted proteins play a vital physiological role. Schizosaccharomyces pombe is an important model organism for cell cycle study and a potential useful drug screen model. Secreted proteins also initiate the mating. However, few global studies concerning the secreted proteins of S. pombe was reported. To address this issue, bioinformatics were used to reveal the global secreted proteins of S. pombe. The 4997 proteins deduced from the S. pombe genome were analyzed by combined several programs. One hundred and sixty proteins were identified carrying an NH2-terminal secretory signal peptide by signalP3.0. Among them, 117 proteins are integral membrane proteins (TMpred), 13 proteins are lipoproteins (PrositeS-can), and 66 proteins are secreted proteins. The location of the secreted proteins was also predicted by Target P. Some of the secreted proteins are involved in the nutrition, reproduction, as well as the communication between cells and environment. The global information of the secreted proteins of S. pombe will benefit further studies in drug screening model and host searching for heterologous gene expression.
Liu
Yu-Ling
YL
Institute of Modern Biopharmaceuticals, School of Life Sciences, Southwest University, Chongqing, China. lyling@swu.edu.cn
Liu
Yun-Fan
YF
Xie
Jian-Ping
JP
D000595:Amino Acid Sequence; D015825:Chromosomes, Fungal / Q000235:genetics; D019295:Computational Biology / Q000379:methods*; D008969:Molecular Sequence Data; D012568:Schizosaccharomyces / Q000235:genetics / Q000378:metabolism*; D029702:Schizosaccharomyces pombe Proteins / Q000032:analysis* / Q000235:genetics
D029702:Schizosaccharomyces pombe Proteins