title: Effect of prolonged emotional and pain stress on the content of methylcytosine-binding protein MeCP2 in nuclei of hippocampal neurons in rats with different excitability of the nervous system.
abstract: In rats with low excitability threshold of the nervous system demonstrating significant and persistent behavioral disorders under stress conditions, the content of methylcytosine-binding protein MeCP2 in neuronal nuclei of hippocampal field CA3 decreased over 2 weeks after long-term emotional and pain stress. It was hypothesized that protein MeCP2 triggers epigenetic changes in DNA that underlie "stress memory".
authors: Laboratory for Genetics of Higher Nervous Activity, Laboratory of Neurogenetics, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg. dyuzhikova@kolt.infran.ru
authors: N A
authors: NA
authors: Dyuzhikova
authors: Yu N
authors: YN
authors: Savenko
authors: N E
authors: NE
authors: Sokolova
authors: E V
authors: EV
authors: Savvateeva-Popova
authors: A I
authors: AI
authors: Vaido
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism*; D006624:Hippocampus / Q000166:cytology*; D008297:Male; D051783:Methyl-CpG-Binding Protein 2 / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism*; D010146:Pain / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D013313:Stress Disorders, Post-Traumatic / Q000378:metabolism*; D013315:Stress, Psychological / Q000378:metabolism*
chemical_list: C497394:Mecp2 protein, rat; D051783:Methyl-CpG-Binding Protein 2