Review of azelastine nasal spray in the treatment of allergic and non-allergic rhinitis.
Azelastine is a potent H(1)-antihistamine, which is available as a topical nasal spray and indicated for both seasonal allergic and non-allergic vasomotor rhinitis. In addition to its antihistaminic effects, it has also been shown to have a number of other potentially important attributes, including effects on cytokines, adhesion molecules and inflammatory cells. Azelastine nasal spray has been shown to benefit patients who have not responded adequately to loratadine and fexofenadine, and is significantly more efficacious than cetirizine and levocabastine in patients with seasonal allergic rhinitis. Given its unique pharmacologic properties and clinical profile, azelastine maintains an important role in the treatment of chronic rhinitis.
Lee
Christina
C
Department of Medicine, Division of Pulmonary and Critical Care Medicine, Section of Clinical Immunology and Allergy, University of California, Los Angeles, Los Angeles, CA, USA.
Corren
Jonathan
J
D000281:Administration, Intranasal; D000818:Animals; D018926:Anti-Allergic Agents / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D001682:Biological Availability; D006801:Humans; D010793:Phthalazines / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D016032:Randomized Controlled Trials as Topic; D012220:Rhinitis / Q000145:classification / Q000188:drug therapy* / Q000503:physiopathology
D018926:Anti-Allergic Agents; D010793:Phthalazines; C020976:azelastine