title: Serum leptin levels in women with uterine leiomyomas.
abstract: OBJECTIVE
  The purpose of this study was to examine the influence of leptin in women with uterine myoma.
  
  
  METHODS
  In this study, 38 women with myoma uteri and 30 normal women who applied to the Dr Zekai Tahir Burak Woman Health Research and Education Hospital's gynecology clinic were enrolled. Uterine leiomyomas were proved by pathology postoperatively. In all subjects, FSH, LH, E2, prolactin, hemoglobin, hematocrit, blood urea nitrogen, creatinine, fasting glucose, CA125, and leptin were examined, and body mass index (BMI) was calculated. Data were analyzed by Student's t test and Mann-Whitney U test.
  
  
  RESULTS
  Although leptin level was higher in the myomatic women (5.73 +/- 4.08 ng/mL) than in the normal women, there was no statistically significant difference (p = 0.303). Also, no statistical difference in the ratios of leptin/BMI was found in both groups. A significant correlation was found between high E2 level and myoma uteri (p = 0.021). Hemoglobin levels were significantly lower in the myomatic women (p = 0.044). When we compared the leptin levels according to BMI, leptin levels were higher in patients who had BMI > 30 (p = 0.02).
  
  
  CONCLUSIONS
  We did not find any significant difference in serum leptin levels between the two groups. But leptin may have an indirect role in the pathogenesis of uterine leiomyoma. So further research is needed to reveal the role of leptin in myoma uteri pathogenesis.
authors: Department of Obstetrics and Gynecology, Dr Zekai Tahir Burak Woman Health Research and Education Hospital, Ankara, Turkey.
authors: Bihter Senem
authors: BS
authors: Dingiloglu
authors: Tayfun
authors: T
authors: Gungor
authors: Bulent
authors: B
authors: Ozdal
authors: Sabri
authors: S
authors: Cavkaytar
authors: Umit
authors: U
authors: Bilge
authors: Leyla
authors: L
authors: Mollamahmutoglu
mesh_terms: D000328:Adult; D015992:Body Mass Index; D018394:CA-125 Antigen / Q000097:blood; D005260:Female; D006454:Hemoglobins / Q000032:analysis; D006728:Hormones / Q000097:blood; D006801:Humans; D007889:Leiomyoma / Q000097:blood*; D020738:Leptin / Q000097:blood*; D008875:Middle Aged; D014594:Uterine Neoplasms / Q000097:blood*
chemical_list: D018394:CA-125 Antigen; D006454:Hemoglobins; D006728:Hormones; D020738:Leptin