title: Biochemical, physiological, and histological changes in the neotropical fish Prochilodus lineatus exposed to diesel oil.
abstract: Toxicity tests were conducted simulating a diesel oil spill in a tropical environment and juveniles of Prochilodus lineatus were exposed to the water-soluble fraction of diesel oil (WSD) for 6, 24, 96 h, and 15 days. The results showed the activation of biotransformation pathways for xenobiotics, through a time-dependent increase of liver GST activity. WSD caused a decrease in hematocrit and hemoglobin content, very likely due to hemolysis. Furthermore, an increase in glucose levels was observed after acute exposure to WSD. A possible lack of cortisol response could also be associated with WSD, since a reduction in plasma cortisol was seen in fish exposed to the petroleum product for 15 days. Moreover, the occurrence of lesions in the gills and even more severe lesions in the liver, should lead to functional damage to both organs, interfering thus directly with fundamental processes for the maintenance of homeostasis in this fish.
authors: Departamento de Ciências Fisiológicas, Universidade Estadual de Londrina, C.P. 6001, CEP:86051-990, Londrina, Paraná, Brasil.
authors: Juliana Delatim
authors: JD
authors: Simonato
authors: Carmen L B
authors: CL
authors: Guedes
authors: Cláudia B R
authors: CB
authors: Martinez
mesh_terms: D000818:Animals; D001786:Blood Glucose; D002374:Catalase / Q000378:metabolism; D005399:Fishes; D005742:Gasoline / Q000633:toxicity*; D005880:Gills / Q000473:pathology; D005982:Glutathione Transferase / Q000378:metabolism; D006854:Hydrocortisone / Q000097:blood; D008099:Liver / Q000201:enzymology / Q000473:pathology; D018675:Toxicity Tests; D014874:Water Pollutants, Chemical / Q000633:toxicity*
chemical_list: D001786:Blood Glucose; D005742:Gasoline; D014874:Water Pollutants, Chemical; D002374:Catalase; D005982:Glutathione Transferase; D006854:Hydrocortisone