title: Antifungal agent and other constituents from Cynanchum otophyllum.
abstract: Seven constituents were isolated from the ethyl acetate extract of the rhizome of Cynanchum otophyllum Schneid (Asclepiadaceae). Their structures were determined as 1-(4-methoxy-3-(6-methoxy-3-acetylphenylperoxy)phenyl)ethanone (1), 1-(3-hydroxy-7-acetylnaphthalen-2-yl)ethanone (2), 1-(3,4-dihydroxyphenyl)ethanone (3), 1-(2,4-dihydroxyphenyl)ethanone (4), 1-(3-(3,6-dihydroxy-2-methylbenzoyl)-2,4-dihydroxyphenyl)ethanone (beishouwubenzophenone) (5), N,N-dimethylethanamine (6), and 2-oxo-2-phenylacetic acid (7), respectively, by spectral methods. Among them, 1 and 2 were new compounds; 1 had antifungal activity.
authors: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany. The Chinese Academy of Sciences, Kunming, Yunnan 650204, People' s Republic of China.
authors: Yi-Bin
authors: YB
authors: Zhao
authors: Yue-Mao
authors: YM
authors: Shen
authors: Hong-Ping
authors: HP
authors: He
authors: Quan-Zhang
authors: QZ
authors: Mu
authors: Xiao-Jiang
authors: XJ
authors: Hao
mesh_terms: D000085:Acetates; D000935:Antifungal Agents / Q000302:isolation & purification* / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects; D002177:Candidiasis / Q000382:microbiology; D031105:Cynanchum / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D009281:Naphthalenes / Q000302:isolation & purification* / Q000494:pharmacology*; D010545:Peroxides / Q000302:isolation & purification* / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry; D012997:Solvents; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
chemical_list: C519442:1-(3-hydroxy-7-acetylnaphthalen-2-yl)ethanone; C519438:1-(4-methoxy-3-(6-methoxy-3-acetylphenylperoxy)phenyl)ethanone; D000085:Acetates; D000935:Antifungal Agents; D009281:Naphthalenes; D010545:Peroxides; D012997:Solvents; C007650:ethyl acetate