Incidence of side-effects of ticlopidine after sirolimus-eluting stent implantation.
BACKGROUND
Because of its side-effects, long-term administration of ticlopidine limits the use of the sirolimus-eluting stent (SES) in Japan.


RESULTS
Side-effects of ticlopidine occurred in 41 (9.3%) of 440 patients who underwent SES implantation. The majority were liver dysfunction (4.5%) and rash (3.6%). One patient died from severe liver dysfunction. Neutropenia occurred in 3 patients (0.7%). It is remarkable that 28% of side-effects occurred >8 weeks after the initiation of ticlopidine.


CONCLUSIONS
Ticlopidine has a relative high rate of side-effects. Clopidogrel should be approved for prevention of stent thrombosis as soon as possible.
Fukushima
Kenichi
K
Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine.
Kobayashi
Yoshio
Y
Okuno
Tomonobu
T
Nakamura
Yoshitake
Y
Sakakibara
Masayoshi
M
Nakayama
Takashi
T
Kuroda
Nakabumi
N
Miyazaki
Akira
A
Shimizu
Youichi
Y
Komuro
Issei
I
D000368:Aged; D019917:Blood Vessel Prosthesis Implantation / Q000379:methods; D056486:Chemical and Drug Induced Liver Injury; D003328:Coronary Thrombosis / Q000517:prevention & control*; D004305:Dose-Response Relationship, Drug; D004343:Drug Implants; D064420:Drug-Related Side Effects and Adverse Reactions; D005076:Exanthema / Q000139:chemically induced; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D015994:Incidence; D007564:Japan; D008297:Male; D008875:Middle Aged; D010975:Platelet Aggregation Inhibitors / Q000009:adverse effects*; D012189:Retrospective Studies; D020123:Sirolimus / Q000008:administration & dosage*; D015607:Stents; D013988:Ticlopidine / Q000009:adverse effects*
D004343:Drug Implants; D007166:Immunosuppressive Agents; D010975:Platelet Aggregation Inhibitors; D013988:Ticlopidine; D020123:Sirolimus