CAPN10 alleles modify laryngeal cancer risk in the Spanish population.
OBJECTIVE
Laryngeal carcinoma is a common upper respiratory tract cancer with different environmental and genetic factors involved in its development. To date, CAPN10 has been found to be extensively associated with hyperinsulinaemia and type 2 diabetes mellitus, by different groups. In addition, some reports have shown evidence that hyperinsulinaemia exerts a protective effect on laryngeal cancer risk. On the other hand, low circulating levels of IGF-1 have been recently found in patients with laryngeal carcinoma. Our objective was to examine the contribution of CAPN10 alleles to the development of laryngeal cancer.


METHODS
Cases and controls were recruited from central and southern Spain. Genotypes were determined using pyrosequencing technology. We analysed CAPN10 UCSNP-44, -43, -19, and -63 allelic distribution in 218 unrelated laryngeal cancer patients and 606 controls from the general population.


RESULTS
We found that the UCSNP-44 allele-C is significantly under-represented among patients with laryngeal cancer (OR=0.685, p=0.02).


CONCLUSIONS
These results indicate that some CAPN10 alleles may be exerting a protective effect on laryngeal cancer risk in the Spanish population.
Esteban
F
F
Servicio de Otorrinolaringologia, Hospital Universitario Virgen del Rocío, Avda Manuel Siurot s/n, 41013 Sevilla, Spain.
Royo
J L
JL
González-Moles
M A
MA
Gonzalez-Perez
A
A
Redondo
M
M
Moreno-Luna
R
R
Rodríguez-Sola
M
M
Gonzalez
A
A
Real
L M
LM
Ruiz
A
A
Ramírez-Lorca
R
R
D000483:Alleles; D002154:Calpain / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D006239:Haplotypes; D006801:Humans; D007822:Laryngeal Neoplasms / Q000201:enzymology* / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D013030:Spain; D044465:White People / Q000235:genetics*
D002154:Calpain; C415197:calpain 10