title: Correlation between the permeability of metoprolol tartrate through plasticized isolated ethylcellulose/hydroxypropyl methylcellulose films and drug release from reservoir pellets.
abstract: The present study investigates if drug diffusion through plasticized isolated ethylcellulose (EC)/hydroxypropyl methylcellulose (HPMC) films prepared by solvent casting can be used as a tool to develop spray-coated dosage forms. In particular, the importance of the level and type of plasticizers was investigated. The permeability of the model drug metoprolol tartrate through plasticized isolated films could be adjusted by selecting the type and amount of plasticizer in the films due to the different hydrophilicity of the plasticizers. The release of metoprolol tartrate from coated pellets is consistent with the drug diffusion through the films made up of the same polymer blends. This indicated that it is useful to test isolated films for early predictions and for formulation optimization.
authors: Laboratorium voor Farmacotechnologie en Biofarmacie, Katholieke Universiteit Leuven, Leuven, Belgium.
authors: Zhi-wei
authors: ZW
authors: Ye
authors: Patrick
authors: P
authors: Rombout
authors: Jean Paul
authors: JP
authors: Remon
authors: Chris
authors: C
authors: Vervaet
authors: Guy
authors: G
authors: Van den Mooter
mesh_terms: D002482:Cellulose / Q000031:analogs & derivatives / Q000737:chemistry; D002626:Chemistry, Pharmaceutical / Q000379:methods; D002851:Chromatography, High Pressure Liquid; D003692:Delayed-Action Preparations; D004058:Diffusion; D004867:Equipment Design; D065347:Hypromellose Derivatives; D008747:Methylcellulose / Q000031:analogs & derivatives / Q000737:chemistry; D008790:Metoprolol / Q000737:chemistry*; D010539:Permeability; D010968:Plasticizers / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D013678:Technology, Pharmaceutical / Q000379:methods; D013997:Time Factors
chemical_list: D003692:Delayed-Action Preparations; D010968:Plasticizers; D011108:Polymers; D065347:Hypromellose Derivatives; C013517:ethyl cellulose; D002482:Cellulose; D008747:Methylcellulose; D008790:Metoprolol