Modulatory action of combined treatment with antibodies against S100 protein and low doses of this protein on membrane effects of quinine.
Antibodies against calcium-binding protein S100 (AB-S100) 1.5-fold increased, while quinine 2-fold decreased the frequency of action potential generation in B4 and B6 neurons. Application of quinine against the background of AB-S100 treatment returned this parameter to the initial level. Pretreatment with AB-S100 in low doses prevents changes the frequency of action potential generation induced by application of AB-S100 in the initial dilution. The duration of action potential increased by 1.6 times after application of AB-S100 and quinine, while after application of quinine increased this parameter by more than 6 times. AB-S100 decreased maximum inward current by 20%. Our experiments demonstrated a modulating effect of combined administration of AB-S100 and its low doses on the membrane effects of quinine.
Epstein
O I
OI
Materia Medica Holding Research-and-Production Company, Moscow.
Shtark
M B
MB
Andrianov
V V
VV
Gainutdinov
Kh L
KhL
Gainutdinova
T Kh
TKh
Silant'eva
D I
DI
D000200:Action Potentials / Q000187:drug effects* / Q000502:physiology; D000818:Animals; D000906:Antibodies / Q000494:pharmacology*; D002462:Cell Membrane / Q000187:drug effects; D006372:Helix, Snails / Q000502:physiology*; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D011803:Quinine / Q000494:pharmacology*; D009418:S100 Proteins / Q000276:immunology*; D018709:Statistics, Nonparametric
D000906:Antibodies; D009418:S100 Proteins; D011803:Quinine