Urticarial vasculitis secondary to paroxetine.
Paroxetine (Paxil) is a widely prescribed antidepressant of the selective serotonin reuptake inhibitor (SSRI) class for which multiple cutaneous adverse effects have been reported, including urticaria, ecchymoses, vasculitis, and pruritus. In contrast, fluoxetine (Prozac) is the only SSRI previously reported to cause urticarial vasculitis. Urticarial vasculitis is a chronic disorder marked by recurrent episodes of erythematous, indurated wheals that histologically manifest the features of leukocytoclastic vasculitis. This case represents the first reported incidence of paroxetine-induced urticarial vasculitis, and highlights the need to consider the entire SSRI class as s as a potential cause of the condition.
Welsh
John Patrick
JP
Drexel University College of Medicine, Department of Dermatology, Philadelphia, PA 19107, USA. jpw32@drexel.edu
Cusack
Carrie Ann
CA
Ko
Christine
C
D003866:Depressive Disorder / Q000188:drug therapy; D006801:Humans; D008875:Middle Aged; D017374:Paroxetine / Q000009:adverse effects* / Q000627:therapeutic use; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects / Q000627:therapeutic use; D012867:Skin / Q000098:blood supply / Q000187:drug effects / Q000473:pathology; D014581:Urticaria / Q000139:chemically induced*; D014657:Vasculitis / Q000139:chemically induced* / Q000175:diagnosis
D017374:Paroxetine; D017367:Selective Serotonin Reuptake Inhibitors