Neuroprotective effects of vitamin E in cold induced cerebral injury in guinea pigs.
Significant reduction in hemorrhage (10 v/s 13), necrosis (2 v/s 4), cavitations (7 v/s 13), neuronal degeneration, perivascular and parenchymal inflammatory infiltrate (7 v/s 11) were observed in Vitamin E treated cold induced head injury in guinea pigs, evaluated post injury using the modified Benderson's scale. The results suggest that Vitamin E is highly effective in promoting clinical and histopathological recovery in cold induced head injury in guinea pigs.
Badhe
Prerna
P
Department of Neurosurgery, Lokmanya Tilak Municipal Medical College & General Hospital, Sion, Mumbai 400 022, India. prernabadhe@yahoo.co.in
Thorat
Jayant
J
Diyora
Batuk D
BD
Mamidanna
Ravikrishna
R
Sayal
Parag
P
Badhe
Suvarna
S
Sharma
Alok K
AK
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D001921:Brain / Q000473:pathology; D001930:Brain Injuries / Q000188:drug therapy* / Q000473:pathology; D003080:Cold Temperature; D005260:Female; D006168:Guinea Pigs; D008297:Male; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D011897:Random Allocation; D014810:Vitamin E / Q000627:therapeutic use*
D000975:Antioxidants; D018696:Neuroprotective Agents; D014810:Vitamin E