Workgroup report: review of fish bioaccumulation databases used to identify persistent, bioaccumulative, toxic substances.
Chemical management programs strive to protect human health and the environment by accurately identifying persistent, bioaccumulative, toxic substances and restricting their use in commerce. The advance of these programs is challenged by the reality that few empirical data are available for the tens of thousands of commercial substances that require evaluation. Therefore, most preliminary assessments rely on model predictions and data extrapolation. In November 2005, a workshop was held for experts from governments, industry, and academia to examine the availability and quality of in vivo fish bioconcentration and bioaccumulation data, and to propose steps to improve its prediction. The workshop focused on fish data because regulatory assessments predominantly focus on the bioconcentration of substances from water into fish, as measured using in vivo tests or predicted using computer models. In this article we review of the quantity, features, and public availability of bioconcentration, bioaccumulation, and biota-sediment accumulation data. The workshop revealed that there is significant overlap in the data contained within the various fish bioaccumulation data sources reviewed, and further, that no database contained all of the available fish bioaccumulation data. We believe that a majority of the available bioaccumulation data have been used in the development and testing of quantitative structure-activity relationships and computer models currently in use. Workshop recommendations included the publication of guidance on bioconcentration study quality, the combination of data from various sources to permit better access for modelers and assessors, and the review of chemical domains of existing models to identify areas for expansion.
Weisbrod
Anne V
AV
Central Product Safety, The Procter and Gamble Company, Cincinnati, Ohio 45252, USA. weisbrod.av@pg.com
Burkhard
Lawrence P
LP
Arnot
Jon
J
Mekenyan
Ovanes
O
Howard
Philip H
PH
Russom
Christine
C
Boethling
Robert
R
Sakuratani
Yuki
Y
Traas
Theo
T
Bridges
Todd
T
Lutz
Charles
C
Bonnell
Mark
M
Woodburn
Kent
K
Parkerton
Thomas
T
D000818:Animals; D016208:Databases, Factual; D004784:Environmental Monitoring; D005399:Fishes / Q000378:metabolism*; D008954:Models, Biological; D008956:Models, Chemical; D018570:Risk Assessment; D014874:Water Pollutants, Chemical / Q000032:analysis* / Q000378:metabolism / Q000633:toxicity
D014874:Water Pollutants, Chemical