title: Sodium and kidney disease.
abstract: Salt is essential and important for maintaining life. Excess salt intake produces an increase in blood pressure. In several subpopulations of patients with hypertension, such as those with obesity, post-menopausal women, and patients with chronic kidney diseases, for example, salt sensitivity is based on a pressure-natriuresis mechanism. In this mechanism, neuro-humoral regulation is mainly responsible for sodium handling. In addition, NO has a powerful effect on the pressure-natriuresis mechanism. Based on this mechanism, progression of chronic kidney disease is governed by salt uptake. Moreover, a genetic component for salt sensitivity is important in normotensive subjects with a family history of hypertension. In these regards, modulation of salt is of utmost importance in the fields of hypertension and nephrology.
authors: Department of Nephrology, Saitama Medical University, Saitama, Japan.
authors: Hiromichi
authors: H
authors: Suzuki
authors: Tsuneo
authors: T
authors: Takenaka
authors: Yoshihiko
authors: Y
authors: Kanno
authors: Yoichi
authors: Y
authors: Ohno
authors: Takao
authors: T
authors: Saruta
mesh_terms: D001794:Blood Pressure / Q000502:physiology; D002908:Chronic Disease; D018450:Disease Progression; D020022:Genetic Predisposition to Disease; D006801:Humans; D006973:Hypertension / Q000139:chemically induced / Q000150:complications / Q000503:physiopathology; D007674:Kidney Diseases / Q000209:etiology* / Q000503:physiopathology; D009318:Natriuresis / Q000502:physiology; D012084:Renin-Angiotensin System / Q000502:physiology; D012982:Sodium, Dietary / Q000009:adverse effects*
chemical_list: D012982:Sodium, Dietary