Processing of auditory and visual location information in the monkey prefrontal cortex.
Visuospatial working memory mechanisms have been studied extensively at single cell level in the dorsolateral prefrontal cortex (PFCd) in nonhuman primates. Despite the importance of short-term memory of sound location for behavioral orientation, there are only a few studies on auditory spatial working memory. The purpose of this study was to investigate neuronal mechanisms underlying working memory processing of auditory and visual location information at single cell level in the PFCd. Neuronal activity was recorded in monkeys performing a delayed matching-to-sample task (DMTS). The location of a visual or auditory stimulus was used as a memorandum. The majority of the neurons that were activated during presentation of the cue memorandum were selective either for visual or auditory spatial information. A small group of cue related bimodal neurons were sensitive to the location of the cue regardless of whether the stimulus was visual or auditory, suggesting modality independent processing of spatial information at cellular level in the PFCd. Most neurons that were activated during the delay period were modality specific, responding either during visual or auditory trials. All bimodal delay related neurons that responded during both visual and auditory trials were spatially nonselective. The results of the present study suggest that in addition to the modality specific parallel mechanism, working memory of auditory and visual space also involves modality independent processing at cellular level in the PFCd.
Artchakov
Denis
D
Neuroscience Unit, Institute of Biomedicine/physiology, Department of Basic Veterinary Sciences/Physiology, University of Helsinki, P.O. Box 63, Haartmaninkatu 8, 00014 Helsinki, Finland.
Tikhonravov
Dmitry
D
Vuontela
Virve
V
Linnankoski
Ilkka
I
Korvenoja
Antti
A
Carlson
Synnöve
S
D000161:Acoustic Stimulation; D000200:Action Potentials / Q000502:physiology; D000818:Animals; D001307:Auditory Perception / Q000502:physiology*; D001931:Brain Mapping; D003463:Cues; D005260:Female; D008253:Macaca mulatta; D008570:Memory, Short-Term / Q000502:physiology*; D009434:Neural Pathways / Q000502:physiology; D009474:Neurons / Q000502:physiology; D009483:Neuropsychological Tests; D010775:Photic Stimulation; D017397:Prefrontal Cortex / Q000033:anatomy & histology / Q000502:physiology*; D011930:Reaction Time / Q000502:physiology; D013028:Space Perception / Q000502:physiology*; D014796:Visual Perception / Q000502:physiology*