[Hypertonic saline solution for reduction of intracranial pressure. Are there doubts?].
Osmotherapy, i.e. the intravenous administration of hyperosmolar solutions, is one of the mainstays of therapy for reduction of a pathologically increased intracranial pressure, in addition to analgosedation and raising the upper body of the patient. The administration of mannitol as a osmotherapeutic agent is, however, marred by considerable side-effects. A possible alternative is the use of hypertonic saline solution (NaCl). The advantages and disadvantages of this option are considered as well as points still in question.
Theilen
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Klinik und Poliklinik für Anästhesie und Intensivtherapie, Universitätsklinik Carl Gustav Carus der Technischen Universität Dresden, Fetscherstrasse 74, 01307 Dresden. Hermann.Theilen@uniklinikum-dresden.de
Ragaller
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M
Koch
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T
D006801:Humans; D019586:Intracranial Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D007427:Intracranial Pressure / Q000187:drug effects* / Q000502:physiology; D008353:Mannitol / Q000009:adverse effects / Q000627:therapeutic use; D012462:Saline Solution, Hypertonic / Q000627:therapeutic use*
D012462:Saline Solution, Hypertonic; D008353:Mannitol