title: Fluorinated NSC as a Cdc25 inhibitor.
abstract: We report on the fluorinated form of NSC 95397 as a Cdc25B inhibitor, which is predicted to be only an arylator of cysteine-containing proteins, without generating reactive oxygen species.
authors: Department of Bioscience and Biotechnology, Sejong University, 98 Kunja-Dong, Kwangjin-Ku, Seoul 143-747, Republic of Korea.
authors: Hwangseo
authors: H
authors: Park
authors: Brian I
authors: BI
authors: Carr
authors: Minghua
authors: M
authors: Li
authors: Seung Wook
authors: SW
authors: Ham
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry*; D001665:Binding Sites; D018797:Cell Cycle Proteins / Q000037:antagonists & inhibitors*; D002863:Chromogenic Compounds; D005461:Fluorine; D007700:Kinetics; D008958:Models, Molecular; D009285:Naphthoquinones / Q000737:chemistry* / Q000494:pharmacology*; D011485:Protein Binding; D013816:Thermodynamics; D020687:cdc25 Phosphatases / Q000037:antagonists & inhibitors*
chemical_list: C451261:2,3-bis(2-hydroxyethylsulfanyl)-(1,4)naphthoquinone; D000970:Antineoplastic Agents; D018797:Cell Cycle Proteins; D002863:Chromogenic Compounds; D009285:Naphthoquinones; D005461:Fluorine; D020687:cdc25 Phosphatases