title: Relationship between human leucocyte antigen class I and class II and chronic idiopathic urticaria associated with aspirin and/or NSAIDs hypersensitivity.
abstract: BACKGROUND
  HLA genes play a role in the predisposition of several diseases. The aim was to analyze the prevalence of HLA class I phenotypes and HLA-DRB1* genotype in patients with CIU associated with ASA and NSAIDs hypersensitivity (AICU).
  
  
  METHODS
  69 patients with AICU, and 200 healthy subjects.
  
  
  RESULTS
  Subjects with HLA-B44 and HLA-Cw5 antigens were more represented in patients with AICU than in control group. Subjects with HLA-A11, HLA-B13, HLACw4, and HLA-Cw7 antigen were more represented in control group than in patients with AICU. Multiple logistic regression demonstrated an association of HLA-Cw4 and HLA-Cw7 with a lower risk of AICU, whereas carriers of HLA-B44 phenotype had a higher risk of AICU. No differences were found between patients and controls as regards to HLA-DRB1* genotype.
  
  
  CONCLUSIONS
  We observed an association between some HLA class-I antigens and AICU. To the best of our knowledge this is the first description of such association.
authors: Dipartimento de Medicina Clinica e Sperimentale, Policlinico G.B. Rossi, Università di Verona, Italy.
authors: Maria Luisa
authors: ML
authors: Pacor
authors: Gabriele
authors: G
authors: Di Lorenzo
authors: Pasquale
authors: P
authors: Mansueto
authors: Nicola
authors: N
authors: Martinelli
authors: Maria
authors: M
authors: Esposito-Pellitteri
authors: Paola
authors: P
authors: Pradella
authors: Laura
authors: L
authors: Uxa
authors: Gaetana
authors: G
authors: Di Fede
authors: GiovamBattista
authors: G
authors: Rini
authors: Roberto
authors: R
authors: Corrocher
mesh_terms: D000328:Adult; D000483:Alleles; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D001241:Aspirin / Q000009:adverse effects*; D016022:Case-Control Studies; D004342:Drug Hypersensitivity / Q000150:complications* / Q000235:genetics / Q000276:immunology*; D005260:Female; D005787:Gene Frequency; D005802:Genes, MHC Class II; D005838:Genotype; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D015395:Histocompatibility Antigens Class I / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D012307:Risk Factors; D014581:Urticaria / Q000209:etiology* / Q000235:genetics / Q000276:immunology*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; D015395:Histocompatibility Antigens Class I; D001241:Aspirin