Perception of risk of adverse drug reactions by medical students: influence of a 1 year pharmacological course.
OBJECTIVE
To investigate how adverse drug reactions (ADRs) to several classes of drugs are perceived by young medical students before and after a 1 year pharmacology course.


METHODS
The whole cohort of 92 medical students (63 females and 29 males) was questioned during their third year. A visual analogue scale was used to define a score (ranging from 0 to 10) of perceived risk of ADRs associated with each drug class before and at the end of the pharmacological training period.


RESULTS
Before the pharmacology course, hypnotics were ranked as the most dangerous drugs by the medical students, followed by antidepressants and anticoagulants. Contraceptive pills were listed in the last position. After pharmacological training, antidepressants moved into the first position, followed by anticoagulants and hypnotics. When all different drug classes were taken as a whole, the mean (+/-SD) of median scores of the perceived risk were 4.8 (+/-1.3) before and 5.8 (+/-1.5) at the end of the pharmacology course (P < 0.0001). Except for antidiabetics, antihypertensive drugs, tranquillizers, corticosteroids and hypnotics, the perceived risk significantly increased after the pharmacology course for the other drugs. The highest increases were observed for contraceptive pills (+104%, P < 0.01), NSAIDs (+86%, P < 0.01) and aspirin (+56%, P < 0.01).


CONCLUSIONS
Pharmacological training allows young medical students to be aware of potentially serious ADRs associated with drugs, in particular with drugs considered relatively safe (such as NSAIDs and aspirin) by nonhealth professionals.
Durrieu
G
G
Laboratoire de Pharmacologie Médicale et Clinique Unité de Pharmacoépidémiologie EA 3696, IFR 126, Université Paul Sabatier, Faculté de Médecine de Toulouse, Toulouse, France. durrieu@cict.fr
Hurault
C
C
Bongard
V
V
Damase-Michel
C
C
Montastruc
J L
JL
D000328:Adult; D016907:Adverse Drug Reaction Reporting Systems / Q000592:standards*; D015331:Cohort Studies; D004501:Education, Medical / Q000592:standards*; D005260:Female; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D008297:Male; D010600:Pharmacology / Q000193:education* / Q000592:standards