title: [The influence of some retarding agents NOS of dihydrothiazine-thiazoline rank on postradiational of recovery endogenous CFU-S-8 of mice].
abstract: In this work the attempt to estimate a nitric oxide (NO*) role in regulation of the number of pool haemopoietic stem cells at the irradiated mice was made. With this purpose the number of new compounds from dihydrothiazine-thiazoline line was synthesized, their NO-inhibiting activity was investigated in vivo by the method of ESR-spectroscopy of spin trap and their influence on an output endogenous spleen colonies (CFU-S-8) after the total sublethal y-irradiation of mice in a doze of 6 Gy was also investigated. Was shown, that the tested compounds reduced the contents of NO* in a liver tissue of mice which have received an injection of nitric oxide synthesis inductor - lipopolysaccharide, and also increased an output CFU-S-8 forming endogenous colonies in the spleen of the irradiated mice. Received data testify to perceptivity of search radioprotective agents among NO* synthesis inhibitors.
authors: A G
authors: AG
authors: Konopliannikov
authors: S Ia
authors: SIa
authors: Proskuriakov
authors: O A
authors: OA
authors: Konopliannikov
authors: A I
authors: AI
authors: Trishkina
authors: L V
authors: LV
authors: Shteĭn
authors: Iu G
authors: IuG
authors: Verkhovskiĭ
authors: A I
authors: AI
authors: Kolesnikova
authors: T P
authors: TP
authors: Trofimova
authors: A A
authors: AA
authors: Mandrugin
authors: V M
authors: VM
authors: Fedoseev
authors: S O
authors: SO
authors: Bachurin
authors: A N
authors: AN
authors: Proshin
authors: V G
authors: VG
authors: Skvortsov
mesh_terms: D000818:Animals; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D015672:Erythroid Precursor Cells / Q000187:drug effects* / Q000201:enzymology / Q000528:radiation effects; D008099:Liver / Q000737:chemistry; D008297:Male; D051379:Mice; D009569:Nitric Oxide / Q000032:analysis; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors*; D011837:Radiation-Protective Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013154:Spleen / Q000166:cytology / Q000528:radiation effects; D013843:Thiazines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013844:Thiazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D004791:Enzyme Inhibitors; D011837:Radiation-Protective Agents; D013843:Thiazines; D013844:Thiazoles; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase