title: Is major hepatectomy with pancreatoduodenectomy justified for advanced biliary malignancy?
abstract: OBJECTIVE
  Major hepatectomy with concomitant pancreatoduodenectomy (M-HPD) is usually indicated for the resection of diffuse bile duct cancer or advanced gallbladder cancer. This is the only procedure that can potentially cure such advanced cancers, so both a low mortality rate and long-term survival could potentially justify performing this procedure.
  
  
  METHODS
  Between 1990 and 2005, the morbidity, mortality, and long-term survival of 26 patients with advanced biliary tract carcinoma 14 with diffuse bile duct cancer, 9 with advanced gallbladder cancer, and 3 with hilar bile duct cancer, who underwent hepatopancreatoduodectomy (HPD) were reviewed and analyzed.
  
  
  RESULTS
  The overall morbidity and mortality rates were 30.8% and 0%, respectively. Postoperative infectious complications occurred in 6 patients (23.0%). The 5-year survival rate of the 14 patients with diffuse bile duct cancer who underwent HPD was 51.9%, while the 5-year survival rate in the 12 of these patients who underwent M-HPD was 61.4%. Patients with diffuse bile duct cancer without residual tumor and those without lymph node metastasis had 5-year survival rates of 68.6% and 80%, respectively. Thirty-three percent (2 of 6) of the patients who underwent M-HPD for advanced gallbladder cancer survived for more than 5 years.
  
  
  CONCLUSIONS
  Preoperative biliary drainage, portal embolization, complete external drainage of pancreatic juice, reduction of intraoperative bleeding, and prevention of bacterial colonization of bile may enable the incidence of mortality and hepatic failure to approach zero in patients who undergo HPD. Surgeons should strive for complete clearance of the tumor with a negative surgical margin to achieve long-term survival when performing M-HPD.
authors: Department of Surgery, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano 390-8621, Japan.
authors: Shiro
authors: S
authors: Miwa
authors: Akira
authors: A
authors: Kobayashi
authors: Yasuhiko
authors: Y
authors: Akahane
authors: Takenari
authors: T
authors: Nakata
authors: Motohiro
authors: M
authors: Mihara
authors: Kei
authors: K
authors: Kusama
authors: Shinichiro
authors: S
authors: Ogawa
authors: Junpei
authors: J
authors: Soeda
authors: Shinichi
authors: S
authors: Miyagawa
mesh_terms: D000328:Adult; D000368:Aged; D001650:Bile Duct Neoplasms / Q000401:mortality; D001661:Biliary Tract Neoplasms / Q000401:mortality* / Q000601:surgery*; D005260:Female; D005706:Gallbladder Neoplasms / Q000401:mortality; D006498:Hepatectomy / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016577:Pancreaticoduodenectomy / Q000379:methods*; D016019:Survival Analysis