title: Randomized controlled trial comparing a low-fat diet with a weight-reduction diet in breast cancer-related lymphedema.
abstract: BACKGROUND
  Obesity is considered a risk factor for lymphedema of the arm resulting from breast cancer treatment (BCRL) as well as a poor prognostic factor in response to lymphedema treatment. The aim of the study was to compare the effect of 2 dietary interventions on excess arm volume in BCRL.
  
  
  METHODS
  A total of 64 women with BCRL were randomized to 1 of 3 groups for 24 weeks: 1) weight reduction through reduced energy intake; 2) low-fat diet with no change in energy intake (isoenergetic); 3) control group with no dietary change from habitual intake.
  
  
  RESULTS
  The primary outcome measure was arm volume at 24 weeks. Results showed significant reductions in body weight (P = .006), body mass index (P = .008), and skinfold thickness measured at 4 sites (P = .044) in the weight-reduction and low-fat groups compared with controls. A slightly greater, but not significant (P = .605), fall in excess arm volume occurred in the dietary groups but a significant correlation between weight loss (irrespective of group) and a reduction in excess arm volume (r: 0.423; P = .002) was demonstrated.
  
  
  CONCLUSIONS
  Weight loss, whether through reduced energy intake or low-fat diet, appears to be helpful in the treatment of breast cancer-related lymphedema.
authors: Royal Marsden NHS Foundation Trust, London, UK. clare.shaw@rmh.nhs.uk
authors: Clare
authors: C
authors: Shaw
authors: Peter
authors: P
authors: Mortimer
authors: Patricia A
authors: PA
authors: Judd
mesh_terms: D000368:Aged; D001132:Arm / Q000473:pathology; D015992:Body Mass Index; D001943:Breast Neoplasms / Q000150:complications / Q000601:surgery*; D018752:Diet, Fat-Restricted; D004038:Diet, Reducing; D002149:Energy Intake; D005260:Female; D006801:Humans; D008209:Lymphedema / Q000209:etiology / Q000473:pathology / Q000628:therapy*; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000178:diet therapy*; D015431:Weight Loss