title: Prevalence of dyssynchrony derived from echocardiographic criteria in heart failure patients with normal or prolonged QRS duration.
abstract: Cardiac resynchronization therapy (CRT) for heart failure is targeted at specific patients with mechanical dyssynchrony. We aimed to evaluate the prevalence of dyssynchrony in heart failure patients with either normal or prolonged QRS duration using Doppler imaging. Sixty heart failure patients with idiopathic dilated cardiomyopathy (30 with prolonged QRS duration 30 with normal QRS duration) underwent standard echocardiography and tissue Doppler imaging examinations. Difference between left and right ventricular pre-ejection intervals of more than 40 msec was considered a marker of interventricular dyssynchrony. Intraventricular dyssynchrony was defined as a delay of 60 msec between the time to peak velocities of the septum and left ventricular lateral wall. Patients who have either intra- or interventricular dyssynchrony were defined as with cardiac dyssynchrony. Dyssynchrony was observed in 7 (23.3%) heart failure patients with normal QRS duration versus 26 (86.7%) patients with prolonged QRS duration. There was significant difference between the prevalence of dyssynchrony derived from echo criteria in two groups (P<0.05). Although patients with prolonged QRS duration have a high prevalence of dyssynchrony, yet some still have good cardiac synchronicity. Moreover, dyssynchrony also exists in a small percentage of heart failure patients with normal QRS duration. To identify the potential responders for CRT, both QRS duration and cardiac synchronicity should be assessed.
authors: Centre of Arrhythmia Diagnosis and Treatment, Fu Wai Hospital and Cardiovascular Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China.
authors: Hongxia
authors: H
authors: Niu
authors: Wei
authors: W
authors: Hua
authors: Shu
authors: S
authors: Zhang
authors: Xin
authors: X
authors: Sun
authors: Fangzheng
authors: F
authors: Wang
authors: Keping
authors: K
authors: Chen
authors: Xin
authors: X
authors: Chen
mesh_terms: D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D001783:Blood Flow Velocity; D002311:Cardiomyopathy, Dilated / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000503:physiopathology; D015150:Echocardiography, Doppler / Q000379:methods*; D004562:Electrocardiography; D005260:Female; D006329:Heart Conduction System / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D006333:Heart Failure / Q000000981:diagnostic imaging* / Q000453:epidemiology / Q000503:physiopathology*; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction; D015995:Prevalence; D012107:Research Design; D013318:Stroke Volume