title: The effect of pre-pregnancy weight on delivery outcome and birth weight in potential diabetic patients with normal screening for gestational diabetes mellitus in Siriraj Hospital.
abstract: OBJECTIVE
  To investigate the influence of pre-pregnancy weight on delivery outcome and birth weight in potential diabetic women with normal glucose tolerance.
  
  
  METHODS
  Retrospective Cohort study.
  
  
  METHODS
  The medical records of 660 pregnant women, who attended the antenatal clinic and delivered at Siriraj Hospital between January 2003 and December 2005, were reviewed and analyzed. They all had the known pre-pregnancy weight and were at risk of gestational diabetes with the normal glucose tolerance. Any pregnant women without pre-pregnancy weight recorded were excluded from the present study. They were classified into two groups according to the pre-pregnancy BMI, one was the overweight group (BMI > or = 27 kg/m2) and the other was the normal weight group (BMI 20-25 kg/m2). Information of the complications of pregnancy, the route of delivery, birth weight, and neonatal outcomes were collected and analyzed.
  
  
  RESULTS
  The risks of adverse pregnancy outcomes in overweight women, after adjusting for the confounding factors, were significantly increased, including pre-eclampsia (OR 3.87, 95% CI 2.09-7.25, p < 0.001), cesarean delivery (OR 2.22, 95% CI 1.45-3.39, p < 0.001), cephalopelvic disproportion (OR 2.15, 95% CI 1.35-3.42, p = 0.001), and macrosomia (OR 7.59, 95% CI 1.98-29.09, p < 0.001).
  
  
  CONCLUSIONS
  Even though the screening test for gestational diabetes mellitus is normal, the overweight women still have several adverse pregnancy outcomes.
authors: Department of Obstetrics and Gynecology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.
authors: Nisarat
authors: N
authors: Phithakwatchara
authors: Vitaya
authors: V
authors: Titapant
mesh_terms: D000328:Adult; D001724:Birth Weight; D015992:Body Mass Index; D001835:Body Weight; D016640:Diabetes, Gestational / Q000175:diagnosis*; D005260:Female; D006801:Humans; D011247:Pregnancy; D011256:Pregnancy Outcome; D012189:Retrospective Studies; D012307:Risk Factors; D013785:Thailand; D013997:Time Factors