title: Vascular adaptations to 8-week cycling training in older men.
abstract: OBJECTIVE
  Because age-related changes in the large conduit arteries (increased wall thickness, and attenuated arterial compliance and endothelial function) are associated with cardiovascular pathology, prevention is of paramount importance. The effects of endurance training (i.e. walking or cycling) in older humans are assessed in cross-sectional studies, examining the brachial and carotid arteries (supplying non-trained areas). The purpose of this study was to assess the effects of 8-week endurance training in older men on conduit artery characteristics in the trained and non-trained vascular beds.
  
  
  METHODS
  In eight healthy sedentary older men (70 +/- 3 years), characteristics of the large conduit arteries [common femoral (CFA), superficial femoral (SFA), carotid (CA), and brachial artery (BA)] were measured before and after 8-week cycling training. Functional [arterial compliance and flow-mediated dilation (FMD)] and structural (diameter and intima-media thickness) conduit artery properties were measured using echo-Doppler. Peak blood flow, representing structural peripheral adaptations, was measured using venous occlusion plethysmography.
  
  
  RESULTS
  After training, peak leg blood flow was increased (P < 0.01) and baseline diameter and flow were increased in the CFA (P < 0.05). Cycling training enhanced arterial compliance of the SFA (P = 0.03), but did not affect the FMD (P = 0.32) or the intima-media thickness of the SFA. Exercise training did not alter characteristics of the BA or CA.
  
  
  CONCLUSIONS
  Eight weeks of endurance training in older men altered functional and structural characteristics of the lower extremity vasculature, whereas no changes are reported for the conduit arteries in the non-trained areas (BA or in the CA).
authors: Department of Physiology, Institute of Fundamental and Clinical Movement science, Radboud University Nijmegen Medical Centre, The Netherlands.
authors: D H J
authors: DH
authors: Thijssen
authors: P C E
authors: PC
authors: de Groot
authors: P
authors: P
authors: Smits
authors: M T E
authors: MT
authors: Hopman
mesh_terms: D000222:Adaptation, Physiological / Q000502:physiology*; D000368:Aged; D001642:Bicycling / Q000502:physiology*; D001916:Brachial Artery / Q000502:physiology*; D002339:Carotid Arteries / Q000502:physiology*; D015444:Exercise / Q000502:physiology*; D005263:Femoral Artery / Q000502:physiology*; D006801:Humans; D008297:Male; D010807:Physical Endurance / Q000502:physiology