Two new chemical constituents from Daphne odora Thunb. var. marginata.
Two new phenolic constituents, daphnenone (1) and daphneone (2), were isolated from the stem bark of Daphne odora Thunb. var. marginata. Their structures were established on the basis of spectroscopic analysis. Compounds 1 and 2 were tested for cytotoxic activity by MTT assays on five human tumour cell lines, K562, A549, MCF-7, LOVO and HepG2. Compound 1 showed obvious cytotoxic activity against all the five cell lines.
Zhang
W
W
College of Pharmacy, Second Military Medical University, Shanghai, PR China. wdzhangY@hotmail.com
Zhang
W D
WD
Liu
R H
RH
Shen
Y H
YH
Zhang
C
C
Cheng
H S
HS
Fu
P
P
Shan
L
L
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D032364:Daphne / Q000737:chemistry*; D005562:Formazans / Q000378:metabolism; D006801:Humans; D020128:Inhibitory Concentration 50; D020014:K562 Cells; D007659:Ketones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D019906:Nuclear Magnetic Resonance, Biomolecular; D010636:Phenols / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013778:Tetrazolium Salts / Q000378:metabolism
D000972:Antineoplastic Agents, Phytogenic; D005562:Formazans; D007659:Ketones; D010636:Phenols; D010936:Plant Extracts; D013778:Tetrazolium Salts; C079782:MTT formazan