title: Daptomycin produces an enhanced bactericidal activity compared to ceftriaxone, measured by [3H]choline release in the cerebrospinal fluid, in experimental meningitis due to a penicillin-resistant pneumococcal strain without lysing its cell wall.
abstract: Daptomycin monotherapy was superior to ceftriaxone monotherapy and was highly efficacious in experimental pneumococcal meningitis, sterilizing the cerebrospinal fluid (CSF) of three of three rabbits after 4 to 6 h. With daptomycin therapy only a negligible release of [(3)H]choline as marker of cell wall lysis was detectable in the CSF, peaking around 250 cpm/min after 4 h, compared to a peak of around 2,400 cpm/min after 4 to 6 h for the ceftriaxone-treated rabbits.
authors: Department of Internal Medicine, Inselspital, Freiburgstrasse, 3010 Bern, Switzerland.
authors: A
authors: A
authors: Stucki
authors: M
authors: M
authors: Cottagnoud
authors: V
authors: V
authors: Winkelmann
authors: T
authors: T
authors: Schaffner
authors: P
authors: P
authors: Cottagnoud
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D001433:Bacteriolysis; D002443:Ceftriaxone / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D002473:Cell Wall / Q000187:drug effects*; D002555:Cerebrospinal Fluid / Q000378:metabolism / Q000382:microbiology; D002794:Choline / Q000378:metabolism; D017576:Daptomycin / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D004195:Disease Models, Animal; D006801:Humans; D008586:Meningitis, Pneumococcal / Q000188:drug therapy* / Q000382:microbiology; D008826:Microbial Sensitivity Tests; D010403:Penicillin Resistance; D011817:Rabbits; D013296:Streptococcus pneumoniae / Q000187:drug effects*; D016896:Treatment Outcome; D014316:Tritium / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D014316:Tritium; D002443:Ceftriaxone; D002794:Choline; D017576:Daptomycin