Scutiaquinones A and B, perylenequinones from the roots of Scutia myrtina with anthelmintic activity.
Haemonchus contortus is a worm that causes serious infections in livestock. Two new perylenequinones, scutiaquinone A (1) and scutiaquinone B (2), have been isolated from a methanol extract of the roots of Scutia myrtina by bioassay-guided fractionation, using an assay that kills this parasite in vitro. The structures of compounds 1 and 2 were elucidated by analysis of their 1D- and 2D-NMR and MS spectra. The isolation, structure, and anthelmintic activities of compounds 1 and 2 are reported.
Ayers
Sloan
S
Natural Products Chemistry, Merck Research Laboratories, P.O. Box 2000, Rahway, NJ 07065, USA.
Zink
Deborah L
DL
Mohn
Kenneth
K
Powell
Joanne Staats
JS
Brown
Christine M
CM
Murphy
Terry
T
Brand
Robert
R
Pretorius
Seef
S
Stevenson
Dennis
D
Thompson
Donald
D
Singh
Sheo B
SB
D000818:Animals; D000829:Animals, Domestic / Q000469:parasitology*; D000871:Anthelmintics / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006189:Haemonchus / Q000187:drug effects*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010569:Perylene / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D011809:Quinones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D027823:Rhamnaceae / Q000737:chemistry*; D013019:South Africa
D000871:Anthelmintics; D011809:Quinones; C519142:scutiaquinone A; C519143:scutiaquinone B; D010569:Perylene