title: The effect of cognitive behaviour therapy for chronic fatigue syndrome on self-reported cognitive impairments and neuropsychological test performance.
abstract: BACKGROUND
  Patients with chronic fatigue syndrome (CFS) often have concentration and memory problems. Neuropsychological test performance is impaired in at least a subgroup of patients with CFS. Cognitive behavioural therapy (CBT) for CFS leads to a reduction in fatigue and disabilities.
  
  
  OBJECTIVE
  To test the hypothesis that CBT results in a reduction of self-reported cognitive impairment and in an improved neuropsychological test performance.
  
  
  METHODS
  Data of two previous randomised controlled trials were used. One study compared CBT for adult patients with CFS, with two control conditions. The second study compared CBT for adolescent patients with a waiting list condition. Self-reported cognitive impairment was assessed with questionnaires. Information speed was measured with simple and choice reaction time tasks. Adults also completed the symbol digit-modalities task, a measure of complex attentional function.
  
  
  RESULTS
  In both studies, the level of self-reported cognitive impairment decreased significantly more after CBT than in the control conditions. Neuropsychological test performance did not improve.
  
  
  CONCLUSIONS
  CBT leads to a reduction in self-reported cognitive impairment, but not to improved neuropsychological test performance. The findings of this study support the idea that the distorted perception of cognitive processes is more central to CFS than actual cognitive performance.
authors: Expert Centre Chronic Fatigue, Radboud University Nijmegen Medical Centre, P O Box 9011, 6525 EC Nijmegen, The Netherlands. j.knoop@nkcv.umcn.nl
authors: Hans
authors: H
authors: Knoop
authors: Judith B
authors: JB
authors: Prins
authors: Maja
authors: M
authors: Stulemeijer
authors: Jos W M
authors: JW
authors: van der Meer
authors: Gijs
authors: G
authors: Bleijenberg
mesh_terms: D000328:Adult; D003072:Cognition Disorders / Q000209:etiology / Q000628:therapy; D015928:Cognitive Behavioral Therapy; D015673:Fatigue Syndrome, Chronic / Q000150:complications* / Q000523:psychology / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D012647:Self-Assessment; D016896:Treatment Outcome