9-epi-Viridiol, a novel cytotoxic furanosteroid from soil fungus Trichoderma virens.
A novel furanosteroid named 9-epi-viridiol (1), along with viridiol (2) and mevalonic acid (3), was isolated from Trichoderma virens. The structure of 1 was verified by combined spectroscopic data (COSY, HSQC, HMBC and NOESY) to be a C-9 epimer of viridiol. 9-epi-Viridiol exhibited cytotoxicity towards HeLa and KB cells with IC50 values of 19 and 50 microg mL(-1), respectively.
Phuwapraisirisan
Preecha
P
Natural Product Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand. preecha.p@chula.ac.th
Rangsan
Jakaphan
J
Siripong
Pongpun
P
Tip-Pyang
Santi
S
D000734:Androstenediols / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005562:Formazans; D006367:HeLa Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D007624:KB Cells; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009904:Optical Rotation; D013056:Spectrophotometry, Ultraviolet; D013237:Stereoisomerism; D053719:Tandem Mass Spectrometry; D013778:Tetrazolium Salts; D013785:Thailand; D014242:Trichoderma / Q000737:chemistry*
D000734:Androstenediols; D000970:Antineoplastic Agents; D005562:Formazans; D013778:Tetrazolium Salts; C079782:MTT formazan; C055608:viridiol