Evaluation of the relationship between the systemic inflammatory response and cancer-specific survival in patients with primary operable breast cancer.
The relationship between the systemic inflammatory response (as evidenced by elevated C-reactive protein and lowered albumin concentrations), clinico-pathologic status and relapse-free, cancer-specific and overall survival was examined in patients with invasive primary operable breast cancer (n=300). The median follow-up of the survivors was 46 months. During this period, 37 patients relapsed and 25 died of their cancer. On multivariate analysis, only tumour size (P<0.05), albumin (P<0.01) and systemic treatment (P<0.0001) were significant independent predictors of relapse-free, cancer-specific and overall survival. Lower serum albumin concentrations (<or=43 g l(-1)) were associated with deprivation (P<0.05), hormonal receptor negative tumours (P<0.01) and significantly poorer 3-year relapse-free (85 vs 93%, P=0.001) cancer-specific (87 vs 97%, P<0.0001) and overall survival (84 vs 94%, P=0.001) rates. The results of the present study suggest that lower preoperative albumin concentrations, but not elevated C-reactive protein concentrations, predict relapse-free, cancer-specific and overall survival, independent of clinico-pathologic status and treatment in patients undergoing potentially curative surgery for primary operable breast cancer.
Al Murri
A M
AM
Royal Infirmary, University Department of Surgery, Glasgow, UK.
Wilson
C
C
Lannigan
A
A
Doughty
J C
JC
Angerson
W J
WJ
McArdle
C S
CS
McMillan
D C
DC
D000328:Adult; D001943:Breast Neoplasms / Q000097:blood / Q000473:pathology* / Q000601:surgery*; D002097:C-Reactive Protein / Q000378:metabolism; D044584:Carcinoma, Ductal / Q000473:pathology / Q000601:surgery; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000473:pathology; D007958:Leukocyte Count; D008875:Middle Aged; D009367:Neoplasm Staging; D012709:Serum Albumin / Q000378:metabolism; D015996:Survival Rate
D012709:Serum Albumin; D002097:C-Reactive Protein