Modulation of TRPs by PIPs.
The TRP superfamily of cation channels encompasses 28 mammalian members related to the product of the Drosophila trp (transient receptor potential) gene. TRP channels have a widespread distribution in many cell types and organs and gate in response to a broad variety of physical and chemical stimuli; as such, they can be considered as ubiquitous cellular sensors. Several recent studies reported modulation of different TRP channels by phosphoinositides, in particular by phosphatidylinositol 4,5-bisphosphate (PIP(2)). In most cases, PIP(2) promotes TRP channel activation. Here we provide a brief overview of current insights and controversies about the mechanisms and structural determinants of PIP(2)-TRP channel interactions, and zoom in on the regulation of the Ca(2+)- and voltage-gated TRPM4 by phosphoinositides.
Voets
Thomas
T
Laboratory of Ion Channel Research, Division of Physiology, Department of Molecular Cell Biology, KU Leuven, Onderwijs & Navorsing 1, Herestraat 49 bus 802, 3000 Leuven, Belgium. thomas.voets@med.kuleuven.be
Nilius
Bernd
B
D000818:Animals; D008322:Mammals; D008954:Models, Biological; D019269:Phosphatidylinositol 4,5-Diphosphate / Q000378:metabolism; D010716:Phosphatidylinositols / Q000502:physiology; D050053:TRPM Cation Channels / Q000502:physiology; D050051:Transient Receptor Potential Channels / Q000502:physiology*
D019269:Phosphatidylinositol 4,5-Diphosphate; D010716:Phosphatidylinositols; D050053:TRPM Cation Channels; D050051:Transient Receptor Potential Channels