Enhanced release of itraconazole from ordered mesoporous SBA-15 silica materials.
This in vitro study reports on the enhanced release of the hydrophobic drug itraconazole from the ordered mesoporous SBA-15 silica material and on the existence of a critical mesopore diameter for enhancing release.
Mellaerts
Randy
R
Centre for Surface Chemistry and Catalysis, Kasteelpark Arenberg 23, Catholic University of Leuven, BE-3001, Heverlee, Belgium. johan.martens@biw.kuleuven.be.
Aerts
Caroline A
CA
Van Humbeeck
Jan
J
Augustijns
Patrick
P
Van den Mooter
Guy
G
Martens
Johan A
JA
D002152:Calorimetry, Differential Scanning; D017964:Itraconazole / Q000737:chemistry*; D009584:Nitrogen / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry*
C509969:SBA-15; D017964:Itraconazole; D012822:Silicon Dioxide; D009584:Nitrogen