title: Hippocampus-specific fMRI group activation analysis using the continuous medial representation.
abstract: We present a new shape-based approach for regional group activation analysis in fMRI studies. The method restricts anatomical normalization, spatial smoothing and random effects statistical analysis to the space inside and around a structure of interest. Normalization involves finding intersubject correspondences between manually outlined masks, and it leverages the continuous medial representation, which makes it possible to extend surface-based shape correspondences to the space inside and outside of structures. Our approach is an alternative to whole-brain normalization in cases where the latter may fail due to anatomical variability or pathology. It also provides an opportunity to analyze the shape and thickness of structures concurrently with functional activation. We apply the technique to the hippocampus and evaluate it using data from a visual scene encoding fMRI study, where activation in the hippocampus is expected. We produce detailed statistical maps of hippocampal activation, as well as maps comparing activation inside and outside of the hippocampus. We find that random effects statistics computed by the new approach are more significant than those produced using the Statistical Parametric Mapping framework (Friston, K.J., Holmes, A.P., Worsley, K.J., Poline, J.-P., Firth, C.D., Frackowiak, R.S.J. 1994, Statistical parametric maps in functional imaging: a general linear approach. Human Brain Mapping, 2(4): 189-210) at low levels of smoothing, suggesting that greater specificity can be achieved by the new method without a severe tradeoff in sensitivity.
authors: Penn Image Computing and Science Laboratory (PICSL), Department of Radiology, University of Pennsylvania, 3600 Market St., Ste 370, Philadelphia, PA 19104, USA. pauly2@grasp.upenn.edu
authors: Paul A
authors: PA
authors: Yushkevich
authors: John A
authors: JA
authors: Detre
authors: Dawn
authors: D
authors: Mechanic-Hamilton
authors: María A
authors: MA
authors: Fernández-Seara
authors: Kathy Z
authors: KZ
authors: Tang
authors: Angela
authors: A
authors: Hoang
authors: Marc
authors: M
authors: Korczykowski
authors: Hui
authors: H
authors: Zhang
authors: James C
authors: JC
authors: Gee
mesh_terms: D000328:Adult; D000465:Algorithms; D016477:Artifacts; D001921:Brain / Q000033:anatomy & histology / Q000502:physiology; D005260:Female; D006624:Hippocampus / Q000033:anatomy & histology* / Q000502:physiology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D008953:Models, Anatomic; D008959:Models, Neurological