Translation of clinical trial results into practice: temporal patterns of beta-blocker utilization for heart failure at hospital discharge and during ambulatory follow-up.
BACKGROUND
Underutilization of beta-blockers in heart failure (HF) has been widely reported at hospital discharge and in the ambulatory setting. We examined recent temporal patterns of beta-blocker utilization in HF with systolic dysfunction at hospital discharge and over 2-year follow-up.


METHODS
Annual trends of beta-blocker use were examined in a clinical database of patients with ejection fraction < or = 40% discharged after HF hospitalization in 1998-2004 (n = 735). More detailed data on beta-blocker use at discharge and over 2-year follow-up were abstracted for 200 consecutive patients each in 1999-2001 and 2003-2004.


RESULTS
Annual rates of beta-blocker use at discharge increased steadily by 10% per year from 1998-2004 (P < .001), with no sharp increase noted in any single year after publication of clinical trials or guidelines. Use among patients without contraindications increased markedly from 1999-2001 to 2003-2004 at hospital discharge (38.7% vs 82.6%, P < .001) and 2-year follow-up (53.0% vs 84.5%, P < .001). The increase was significant in all examined subgroups. Although > 50% of patients remained on low doses of beta-blockers, a greater proportion trended to reach target doses at 2 years in the later period (25.6% vs 12.5%, P = .13).


CONCLUSIONS
Substantial increase in beta-blocker utilization in HF with systolic dysfunction occurred from 1998 to 2004, demonstrating that high rates of beta-blocker use are being achieved at hospital discharge and maintained in the ambulatory setting after discharge. However, the time lag in translation of scientific evidence into maximal use of beneficial therapy in practice remains a target for quality improvement.
Patel
Parag
P
Department of Medicine, Baylor College of Medicine, Houston, TX, USA.
White
Donna L
DL
Deswal
Anita
A
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000368:Aged; D000553:Ambulatory Care; D002986:Clinical Trials as Topic; D004363:Drug Utilization / Q000706:statistics & numerical data; D005260:Female; D005500:Follow-Up Studies; D006333:Heart Failure / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010351:Patient Discharge; D013997:Time Factors
D000319:Adrenergic beta-Antagonists