Synthesis of 1,3- and 1,2-diphosphatidylglycerol.
A novel phosphonium salt methodology was utilized for the first time to synthesize 1,3-, and 1,2-diphosphatidylglycerol. Optically active 1,2-di-O-acyl-sn-glyceryl phosphate was coupled with unprotected glycerol in the presence of pyridiniumbromide perbromide and triethylamine to yield, after final removal of phosphate protecting group, the title compounds. The 1,2-diphosphatidylglycerol (1,2-isomer of cardiolipin) may be a member of a new class of phospholipids for industrial applications similar to other phosphocholines.
Ahmad
Moghis U
MU
NeoPharm, Inc., 1850 Lakeside Drive, Waukegan, IL 60085, USA.
Krishna
U Murali
UM
Ali
Shoukath M
SM
Choudhury
Sreeti
S
Ahmad
Imran
I
D002308:Cardiolipins / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D009682:Magnetic Resonance Spectroscopy; D021241:Spectrometry, Mass, Electrospray Ionization; D017550:Spectroscopy, Fourier Transform Infrared
D002308:Cardiolipins