title: Nanostructured lipid carriers-containing anticancer compounds: preparation, characterization, and cytotoxicity studies.
abstract: This article describes the development of nanostructured lipid carriers (NLC) as colloidal carriers for two antitumor compounds that possess a remarkable antineoplastic activity. But their limited stability and low solubility in water could give a very low parenteral bioavailability. Results revealed an enhancement of the cytotoxicity effect of drug-loaded NLC on human prostate cancer (PC-3) and human hepatocellular carcinoma (HuH-6, HuH-7) cell lines with respect to that of both free drugs. Results of characterization studies strongly support the potential application of these drugs-loaded NLC as prolonged delivery systems for lipophilic drugs by several administration routes, in particular for intravenous administration.
authors: Istituto per lo Studio dei Materiali Nanostrutturati, sez. di Palermo, Consiglio Nazionale delle Ricerche, Palermo, Italy. marialuisa.bondi@ismn.cnr.it
authors: Maria Luisa
authors: ML
authors: Bondì
authors: Emanuela Fabiola
authors: EF
authors: Craparo
authors: Gaetano
authors: G
authors: Giammona
authors: Melchiorre
authors: M
authors: Cervello
authors: Antonina
authors: A
authors: Azzolina
authors: Patrizia
authors: P
authors: Diana
authors: Anna
authors: A
authors: Martorana
authors: Girolamo
authors: G
authors: Cirrincione
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D004337:Drug Carriers / Q000737:chemistry*; D004339:Drug Compounding; D004563:Electrochemistry; D006801:Humans; D008055:Lipids / Q000737:chemistry*; D053758:Nanoparticles; D010316:Particle Size; D010949:Plasma / Q000737:chemistry; D012995:Solubility
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D008055:Lipids