Gemcitabine radiosensitizes multiple myeloma cells to low let, but not high let, irradiation.
The radiosensitizing properties of gemcitabine in relation to low Linear Energy Transfer (LET) particles (Cobalt 60) and high-LET particles (alpha-RIT (213)Bi-radiolabeled CHX-DTPA-B-B4) were analyzed. Three multiple myeloma cell lines (LP1, RPMI 8226, U266) were irradiated with or without 10 nM gemcitabine 24 h prior to radiation. Gemcitabine led to radiosensitization of LP1 and U266 cells with low-LET (Radiation Enhancement Ratio: 1.55 and 1.49, respectively) but did not radiosensitize any cell line when combined with high-LET.
Supiot
Stéphane
S
Département de Recherche en Cancérologie, Université de Nantes, Nantes, France.
Thillays
Francois
F
Rio
Emmanuel
E
Gouard
Sébastien
S
Morgenstern
Alfred
A
Bruchertseifer
Frank
F
Mahé
Marc-André
MA
Chatal
Jean-François
JF
Davodeau
François
F
Chérel
Michel
M
D000512:Alpha Particles; D000964:Antimetabolites, Antineoplastic / Q000494:pharmacology; D002453:Cell Cycle / Q000187:drug effects / Q000528:radiation effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects / Q000528:radiation effects; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D003841:Deoxycytidine / Q000031:analogs & derivatives* / Q000494:pharmacology; D005720:Gamma Rays; D006801:Humans; D018499:Linear Energy Transfer; D009101:Multiple Myeloma / Q000473:pathology / Q000532:radiotherapy*; D011829:Radiation Dosage; D011836:Radiation Tolerance / Q000187:drug effects*; D011838:Radiation-Sensitizing Agents / Q000494:pharmacology*; D000093542:Gemcitabine
D000964:Antimetabolites, Antineoplastic; D011838:Radiation-Sensitizing Agents; D003841:Deoxycytidine; D000093542:Gemcitabine