Control of quorum sensing by a Burkholderia pseudomallei multidrug efflux pump.
The Burkholderia pseudomallei KHW quorum-sensing systems produced N-octanoyl-homoserine lactone, N-decanoyl-homoserine lactone, N-(3-hydroxy)-octanoyl-homoserine lactone, N-(3-hydroxy)-decanoyl-homoserine lactone, N-(3-oxo)-decanoyl-homoserine lactone, and N-(3-oxo)-tetradecanoyl-homoserine lactone. The extracellular secretion of these acyl-homoserine lactones is dependent absolutely on the function of the B. pseudomallei BpeAB-OprB efflux pump.
Chan
Ying Ying
YY
Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 8 Medical Drive, Singapore 117597, Singapore.
Bian
Hao Sheng
HS
Tan
Theresa May Chin
TM
Mattmann
Margrith E
ME
Geske
Grant D
GD
Igarashi
Jun
J
Hatano
Tomomi
T
Suga
Hiroaki
H
Blackwell
Helen E
HE
Chua
Kim Lee
KL
D015107:4-Butyrolactone / Q000031:analogs & derivatives / Q000378:metabolism; D001425:Bacterial Outer Membrane Proteins / Q000235:genetics / Q000378:metabolism*; D016957:Burkholderia pseudomallei / Q000235:genetics / Q000378:metabolism* / Q000502:physiology; D002851:Chromatography, High Pressure Liquid; D015964:Gene Expression Regulation, Bacterial; D006714:Homoserine / Q000031:analogs & derivatives / Q000378:metabolism; D007783:Lactones / Q000378:metabolism; D009154:Mutation; D053038:Quorum Sensing / Q000235:genetics / Q000502:physiology*
D001425:Bacterial Outer Membrane Proteins; D007783:Lactones; C091088:N-octanoylhomoserine lactone; C088386:homoserine lactone; D006714:Homoserine; D015107:4-Butyrolactone