Depression as a manifestation of latent chronic hypoparathyroidism.
The exact cause of depression in cases of hypoparathyroidism is not known. We report the first case of an elderly patient with a long history of major depression as a complication of an undiagnosed chronic hypoparathyroidism following surgery on a parathyroid adenoma. Her depression was completely eliminated by calcium supplementation therapy to restore the calcium homeostasis in serum. As it is well known that disturbances in the endocrine hypothalamus-pituitary-thyroid system might be consistent findings of depressive disorders concerning neuroendocrinological alterations, this case report and review of literature strongly supports our claim that also parathyroid diseases like chronic hypoparathyroidism, even in its latent form, might be a relevant factor in the development of depressive symptoms.
Bohrer
Thomas
T
Department of Cardiothoracic Surgery, Julius-Maximilians University of Wuerzburg, Wuerzburg, Germany. Bohrer_T.htc@klinik.uni-wuerzburg.de
Krannich
Jens-Holger
JH
D000236:Adenoma / Q000601:surgery*; D000368:Aged; D000928:Antidepressive Agents / Q000627:therapeutic use; D003865:Major Depressive Disorder / Q000175:diagnosis* / Q000209:etiology* / Q000523:psychology; D003937:Diagnosis, Differential; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D049950:Hyperparathyroidism, Primary / Q000601:surgery*; D006996:Hypocalcemia / Q000175:diagnosis / Q000209:etiology / Q000523:psychology; D007011:Hypoparathyroidism / Q000150:complications* / Q000175:diagnosis* / Q000523:psychology; D010282:Parathyroid Neoplasms / Q000601:surgery*; D016105:Parathyroidectomy; D011183:Postoperative Complications / Q000175:diagnosis* / Q000523:psychology; D017211:Treatment Failure
D000928:Antidepressive Agents