title: Undifferentiated embryonal sarcoma of the liver successfully treated with chemotherapy and liver resection.
abstract: Undifferentiated embryonal sarcoma is the third most common malignant tumor of the liver in children, accounting for 13% of hepatic malignancies in this age group. It has been considered an aggressive neoplasm with very poor prognosis until the late 1980s, when long-term survivors were reported after multiagent chemotherapy followed by resection. We, herein, report two pediatric cases of undifferentiated embryonal sarcoma treated successfully with surgical resection after neoadjuvant chemotherapy based on therapy used in childhood soft tissue sarcomas and in childhood hepatic malignancies. The first patient also had a concurrent cerebellar tumor (pilocytic astrocytoma), for which he first underwent craniotomy and resection, delaying the liver tumor resection by 10 weeks. They are alive and tumor free at 48 months (case no. 1) and 18 months (case no. 2) following neoadjuvant chemotherapy and liver resection.
authors: Transplantation Institute, Loma Linda University Medical Center and Children's Hospital, Loma Linda, CA 92354, USA. pbaron@ahs.llumc.edu
authors: Pedro W
authors: PW
authors: Baron
authors: Fatenah
authors: F
authors: Majlessipour
authors: Antranik A
authors: AA
authors: Bedros
authors: Craig W
authors: CW
authors: Zuppan
authors: Ramzi
authors: R
authors: Ben-Youssef
authors: George
authors: G
authors: Yanni
authors: Okechukwu N
authors: ON
authors: Ojogho
authors: Waldo
authors: W
authors: Concepcion
mesh_terms: D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002648:Child; D003131:Combined Modality Therapy; D006498:Hepatectomy; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery*; D008297:Male; D020360:Neoadjuvant Therapy; D012509:Sarcoma / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery*