title: Biosynthesis of antibiotic prodiginines in the marine bacterium Hahella chejuensis KCTC 2396.
abstract: OBJECTIVE
  Hahella chejuensis KCTC 2396 produces red pigments, showing antibacterial and algicidal activities. The main red-coloured metabolite of the pigments was identified as antibiotic prodigiosin. With the expectation that the red pigments are a mixture of a series of close relatives, the aim of the present study is to detect new antibiotic prodigiosin analogues and to analyse the biosynthetic pattern for prodiginines in KCTC 2396.
  
  
  RESULTS
  Except prodigiosin, the other constituents in the red pigments were confirmed as well-known dipyrrolyldipyrromethene prodigiosin, norprodigiosin, and undecylprodiginine. Additionally, four new prodigiosin analogues, each of which was distinguished from prodigiosin (C(5)), according to differences in alkyl chain length (C(3)-C(7)), were detected in small quantities by liquid chromatography mass spectrometry/mass spectrometry spectroscopy. Owing to the presence of a cytotoxic methoxy group, it is expected that all the new prodigiosin analogues are bioactive.
  
  
  CONCLUSIONS
  Four characterized prodiginines, including prodigiosin and four new prodigiosin analogues are produced in different ratio in KCTC 2396. All of the prodiginines possess a common linear tripyrrolyl structure and a cytotoxic methoxy group.
  
  
  CONCLUSIONS
  This study shows for the first time that KCTC 2396 is able to produce antibiotic prodigiosin, undecylprodiginine and new prodigiosin analogues in a mixture of pigments. It is also shown that KCTC 2396 possesses a novel system for the simultaneous production of multiple prodiginines in a single micro-organism.
authors: Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-333, Korea.
authors: D
authors: D
authors: Kim
authors: J S
authors: JS
authors: Lee
authors: Y K
authors: YK
authors: Park
authors: J F
authors: JF
authors: Kim
authors: H
authors: H
authors: Jeong
authors: T-K
authors: TK
authors: Oh
authors: B S
authors: BS
authors: Kim
authors: C H
authors: CH
authors: Lee
mesh_terms: D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D020563:Gammaproteobacteria; D010860:Pigments, Biological / Q000096:biosynthesis*; D011353:Prodigiosin / Q000031:analogs & derivatives* / Q000096:biosynthesis; D012623:Seawater / Q000382:microbiology*
chemical_list: D000900:Anti-Bacterial Agents; D010860:Pigments, Biological; C010307:prodiginine; D011353:Prodigiosin