title: A pilot randomised controlled comparison of continuous veno-venous haemofiltration and extended daily dialysis with filtration: effect on small solutes and acid-base balance.
abstract: OBJECTIVE
  Continuous veno-venous haemofiltration (CVVH) is an established treatment for acute renal failure (ARF). Recently, extended intermittent dialytic techniques have been proposed for the treatment of ARF. The aim of this study was to compare these two approaches.
  
  
  METHODS
  Intensive care unit of tertiary hospital.
  
  
  METHODS
  Sixteen critically ill patients with ARF.
  
  
  METHODS
  Randomised controlled trial.
  
  
  METHODS
  We randomised sixteen patients to three consecutive days of treatment with either CVVH (8) or extended daily dialysis with filtration (EDDf) (8) and compared small-solute, electrolyte and acid-base control.
  
  
  RESULTS
  There was no significant difference between the two therapies for urea or creatinine levels over 3 days. Of 80 electrolyte measurements taken before treatment, 19 were abnormal. All values were corrected as a result of treatment, except for one patient in the CVVH group who developed hypophosphataemia (0.54 mmol/l) at 72 h. After 3 days of treatment, there was a mild but persistent metabolic acidosis in the EDDf group compared to the CVVH group (median bicarbonate: 20 mmol/l vs. 29 mmol/l: p=0.039; median base deficit: -4 mEq/l vs. -2.1 mEq/l, p=0.033).
  
  
  CONCLUSIONS
  CVVH and EDDf as prescribed achieved similar control of urea, creatinine and electrolytes. Acidosis was better controlled with CVVH.
authors: Department of Intensive Care, Austin Health, 3084, Heidelberg, Australia. ian.baldwin@austin.org.au.|School of Nursing and Midwifery, Department of Gerontic Nursing, La Trobe University, Melbourne, Australia. ian.baldwin@austin.org.au.
authors: Ian
authors: I
authors: Baldwin
authors: Department of Intensive Care, Austin Hospital, Melbourne, Australia.
authors: Toshio
authors: T
authors: Naka
authors: School of Nursing and Midwifery, Department of Gerontic Nursing, La Trobe University, Melbourne, Australia.
authors: Bill
authors: B
authors: Koch
authors: Department of Intensive Care, Austin Hospital, Melbourne, Australia.
authors: Nigel
authors: N
authors: Fealy
authors: Department of Intensive Care, Austin Hospital, Melbourne, Australia.
authors: Rinaldo
authors: R
authors: Bellomo
mesh_terms: D018806:APACHE; D000136:Acid-Base Equilibrium; D058186:Acute Kidney Injury / Q000097:blood / Q000628:therapy*; D000368:Aged; D003422:Critical Care; D005260:Female; D006440:Hemofiltration / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D006435:Renal Dialysis / Q000379:methods*