Cytokeratin and filaggrin expression in nevus comedonicus.
To elucidate the pathogenesis of abnormal keratinization in nevus comedonicus, we performed an immunohistochemical study using antikeratin and antifilaggrin (filament-aggregating protein) antibodies. There were no significant differences between nevus comedonicus and normal skin in cytokeratin expression. Although filaggrin was only detected in the granular layer in open comedones, filaggrin was detected in both superficial cells and also intermediate cells in closed comedones, suggesting that filaggrin is involved in the formation of closed comedones. The disorder of terminal differentiation related to filaggrin may play a role in the pathogenesis of abnormal keratinization in nevus comedonicus.
Kurokawa
Ichiro
I
Department of Dermatology, Mie University Graduate School of Medicine, Mie, Japan. kuroichi@clin.medic.mie-u.ac.jp
Nakai
Yasuo
Y
Nishimura
Keisuke
K
Hakamada
Arata
A
Isoda
Ken-ichi
K
Yamanaka
Kei-ichi
K
Mizutani
Hitoshi
H
Tsubura
Airo
A
D000328:Adult; D000091344:Filaggrin Proteins; D006201:Hair Diseases / Q000378:metabolism / Q000473:pathology; D018859:Hair Follicle / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D007381:Intermediate Filament Proteins / Q000096:biosynthesis*; D007633:Keratins / Q000096:biosynthesis*; D008297:Male; D012625:Sebaceous Gland Diseases / Q000378:metabolism / Q000473:pathology*
C000717249:FLG protein, human; D000091344:Filaggrin Proteins; D007381:Intermediate Filament Proteins; D007633:Keratins