title: Antimicrobial activity of cefazolin-impregnated mesh grafts.
abstract: BACKGROUND
  The aim of this study is the preparation and characterization of cefazolin-impregnated meshes (Surgipro; Tyco Healthcare USSC, Norwalk, CT, USA) to be used as antimicrobial devices.
  
  
  METHODS
  During the impregnation, poly(DL-lactide-co-glycolide) solution with cephazolin in dichloromethane was used as coating material. In vitro release experiment was carried out first; later cefazolin-impregnated meshes were evaluated for the characteristics of antimicrobial efficacy and in the last part of the study native and cefazolin-impregnated meshes were implanted in the rats. Cefazolin content was proposed as the effective parameter to control the cefazolin release rate and it was concluded that the higher amounts of initial cefazolin content caused higher release rates. In all cases (or with different cefazolin content for each mesh), the release rates were very rapid in the first 24 h and in the following periods rather slow release rates were obtained.
  
  
  RESULTS
  Antimicrobial activity was increased in the case of cefazolin-impregnated form and this efficiency was also increased by the higher amount of cefazolin in certain mesh pieces. Similar antimicrobial activities were observed in the in vitro studies.
  
  
  CONCLUSIONS
  In this study, almost all of the cefazolin-impregnated mesh grafts showed very high antimicrobial activity compared with the bare mesh (or mesh without cefazolin).
authors: Department of Infectious Disease, Krikkale University, Krikkale, Turkey. kilicd@gmail.com
authors: Dilek
authors: D
authors: Kilic
authors: Canan
authors: C
authors: Agalar
authors: Eylem
authors: E
authors: Ozturk
authors: Emir B
authors: EB
authors: Denkbas
authors: Abdullah
authors: A
authors: Cime
authors: Fatih
authors: F
authors: Agalar
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D001424:Bacterial Infections / Q000188:drug therapy*; D002437:Cefazolin / Q000008:administration & dosage*; D016503:Drug Delivery Systems; D008297:Male; D008826:Microbial Sensitivity Tests; D051381:Rats; D017208:Rats, Wistar; D018709:Statistics, Nonparametric; D013526:Surgical Mesh
chemical_list: D000900:Anti-Bacterial Agents; D002437:Cefazolin