Enantiomeric separation and determination of absolute stereochemistry of asymmetric molecules in drug discovery: building chiral technology toolboxes.
The application of Chiral Technology, or the (extensive) use of techniques or tools for the determination of absolute stereochemistry and the enantiomeric or chiral separation of racemic small molecule potential lead compounds, has been critical to successfully discovering and developing chiral drugs in the pharmaceutical industry. This has been due to the rapid increase over the past 10-15 years in potential drug candidates containing one or more asymmetric centers. Based on the experiences of one pharmaceutical company, a summary of the establishment of a Chiral Technology toolbox, including the implementation of known tools as well as the design, development, and implementation of new Chiral Technology tools, is provided.
McConnell
Oliver
O
Wyeth Research, Chemical and Screening Sciences, Collegeville, PA 19426, USA. mcconno@wyeth.com
Bach
Alvin
A
Balibar
Carl
C
Byrne
Neal
N
Cai
Yanxuan
Y
Carter
Guy
G
Chlenov
Michael
M
Di
Li
L
Fan
Kristi
K
Goljer
Igor
I
He
Yanan
Y
Herold
Don
D
Kagan
Michael
M
Kerns
Edward
E
Koehn
Frank
F
Kraml
Christina
C
Marathias
Vasilios
V
Marquez
Brian
B
McDonald
Leonard
L
Nogle
Lisa
L
Petucci
Christopher
C
Schlingmann
Gerhard
G
Tawa
Gregory
G
Tischler
Mark
M
Williamson
R Thomas
RT
Sutherland
Alan
A
Watts
William
W
Young
Mairead
M
Zhang
Mei-Yi
MY
Zhang
Yingru
Y
Zhou
Dahui
D
Ho
Douglas
D
D002626:Chemistry, Pharmaceutical / Q000379:methods*; D002845:Chromatography / Q000379:methods; D002942:Circular Dichroism; D015195:Drug Design; D004345:Drug Industry / Q000379:methods*; D004583:Electrons; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008956:Models, Chemical; D008968:Molecular Conformation; D012492:Salts / Q000494:pharmacology; D013237:Stereoisomerism; D013678:Technology, Pharmaceutical / Q000379:methods
D012492:Salts