Oxytocin infusion in laparoscopic myomectomy may decrease operative blood loss.
OBJECTIVE
To evaluate the influence of oxytocin on operative blood loss during laparoscopic myomectomy (LM).


METHODS
Prospective clinical study (Canadian Task Force classification I).


METHODS
Tertiary care university hospital.


METHODS
Sixty women scheduled for myomectomy because of symptomatic uterine myomas.


METHODS
Two ampules of oxytocin (10 u/mL/amp) were added to 1000 mL of saline solution running at the rate of 40 mU/min during the course of LM.


RESULTS
Blood loss and blood transfusion rate were significantly greater in the group without oxytocin infusion (group B) than in the group with oxytocin infusion (group A), with 445.0 +/- 268.6 mL (95% CI 344.7-545.3) versus 269.5 +/- 225.8 mL (95% CI 185.2-353.8)/(p <.05), and 36.7% versus 6.7% (p <.05), respectively. There was no significant difference in average age, body weight, or numbers of vaginal delivery and cesarean sections between the 2 groups. There was no significant difference in mean total myoma weight, main myoma size, postoperative stay, and complications between the 2 groups.


CONCLUSIONS
Oxytocin infusion combined with skillful surgical techniques may decrease operative blood loss and blood transfusion during LM.
Wang
Chin-Jung
CJ
Department of Obstetrics and Gynecology, Division of Gynecologic Endoscopy, Chang Gung Memorial Hospital, Linkou Medical Center and Chang Gung University College of Medicine, Kwei-Shan, Tao-Yuan, Taiwan. wang2260@cgmh.org.tw
Lee
Chyi-Long
CL
Yuen
Leung-To
LT
Kay
Nari
N
Han
Chien-Min
CM
Soong
Yung-Kuei
YK
D000328:Adult; D016063:Blood Loss, Surgical / Q000517:prevention & control*; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D010535:Laparoscopy / Q000009:adverse effects*; D018231:Leiomyomatosis / Q000601:surgery*; D010120:Oxytocics / Q000008:administration & dosage / Q000627:therapeutic use*; D010121:Oxytocin / Q000008:administration & dosage / Q000627:therapeutic use*; D011446:Prospective Studies; D014594:Uterine Neoplasms / Q000601:surgery*
D010120:Oxytocics; D010121:Oxytocin