title: A non-alcoholic patient with acute Marchiafava-Bignami disease associated with gynecologic malignancy: paraneoplastic Marchiafava-Bignami disease?
abstract: We report a 45-year-old, non-alcoholic woman with ovarian cancer who presented with acute impairment of consciousness. Cranial MRI revealed symmetrical and bilateral increased signal intensities of the corpus callosum and the dentate nucleus, without contrast enhancement. The findings are comparable with Marchiafava-Bignami disease (MBD), although pathological confirmation was not possible. Most of the reported cases of MBD are related to chronic ingestion of red wine and/or related with a nutritional cause. We suggest that this patient may suffer a MBD possible related to the ovarian cancer.
authors: Trakya University School of Medicine, Department of Neurology, Edirne, Turkey. celikyahyatr@yahoo.com <celikyahyatr@yahoo.com>
authors: Yahya
authors: Y
authors: Celik
authors: Osman
authors: O
authors: Temizoz
authors: Hakan
authors: H
authors: Genchellac
authors: Bilge
authors: B
authors: Cakir
authors: Talip
authors: T
authors: Asil
mesh_terms: D000428:Alcohol Drinking / Q000009:adverse effects; D001927:Brain Diseases / Q000175:diagnosis*; D002529:Cerebellar Nuclei / Q000473:pathology; D003244:Consciousness Disorders / Q000175:diagnosis; D003337:Corpus Callosum / Q000473:pathology; D004292:Dominance, Cerebral / Q000502:physiology; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009122:Muscle Hypertonia / Q000175:diagnosis; D009367:Neoplasm Staging; D009460:Neurologic Examination; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000473:pathology; D020362:Paraneoplastic Cerebellar Degeneration / Q000175:diagnosis; D020361:Paraneoplastic Syndromes, Nervous System / Q000175:diagnosis*; D014920:Wine / Q000009:adverse effects