title: Scavenging effects of phenolic compounds on reactive oxygen species.
abstract: Phenolic compounds are widely present in plants and they have received considerable attention due to their antioxidant property. In this article we report the results of a study of the reactivity of 10 selected phenolics (sesamol, three phenolic acids, three flavonols, one flavone, and two flavanones) with superoxide anion radical (O(2) (*)), hydroxyl radical (HO(*)) and singlet oxygen ((1)O(2)). The following generators of reactive oxygen species were used: 18-crown-6/KO(2)/dimethylsulfoxide (DMSO) or hypoxanthine/xanthine oxidase as sources of O(2) (*), the Fenton reaction carried out in a sodium trifluoroacetate (pH 6.15) for HO(*), and a mixture of alkaline aqueous H(2)O(2) and cobalt ions for (1)O(2). We have employed chemiluminescence, electron spin resonance spin trapping, and spectrophotometry techniques to examine an antioxidative property. All tested compounds acted as scavengers of various reactive oxygen species. The reactivity indexes (beta) for the reaction of the phenolic compounds with HO(*) were calculated.
authors: Pharmaceutical and Medicinal Chemistry Department, The Pharmaceutical and Drug Industries Research Division, National Research Centre, Dokki, Cairo 12311, Egypt. hyaboulenein@yahoo.com
authors: Hassan Y
authors: HY
authors: Aboul-Enein
authors: Irena
authors: I
authors: Kruk
authors: Aleksandra
authors: A
authors: Kładna
authors: Krzysztof
authors: K
authors: Lichszteld
authors: Teresa
authors: T
authors: Michalska
mesh_terms: D004578:Electron Spin Resonance Spectroscopy; D016166:Free Radical Scavengers / Q000737:chemistry / Q000494:pharmacology*; D017665:Hydroxyl Radical / Q000032:analysis / Q000378:metabolism; D049449:Luminescence; D008163:Luminescent Measurements; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry*; D017382:Reactive Oxygen Species / Q000032:analysis / Q000378:metabolism*; D026082:Singlet Oxygen / Q000032:analysis / Q000378:metabolism; D013113:Spin Labels; D019097:Spin Trapping; D013481:Superoxides / Q000032:analysis / Q000378:metabolism
chemical_list: D016166:Free Radical Scavengers; D010636:Phenols; D017382:Reactive Oxygen Species; D013113:Spin Labels; D013481:Superoxides; D026082:Singlet Oxygen; D017665:Hydroxyl Radical