Genetics of sleep and sleep disorders.
Genetic factors affect sleep. Studies in twin pairs demonstrate that the strong hereditary influences on sleep architecture and some sleep disorders are transmitted through families. Evidence like this strongly suggests that sleep regulation receives significant influence from genetic factors. Although recent molecular technologies have revealed evidence that genetic traits or gene products trigger particular changes in sleep electroencephalogram activity, we are still far from finding candidate genes or multiple mutations responsible for individual sleep disorders. Sleep is a very complex phenotype. Genetic susceptibility and environmental factors should be also considered as contributors to sleep phenotype. The aim of this review is to present a current summary and future prospects for genetic studies on sleep and selected sleep-associated disorders.
Kimura
M
M
Max Planck Institute of Psychiatry, Munich, Germany. kimura@mpipsykl.mpg.de
Winkelmann
J
J
D000818:Animals; D004569:Electroencephalography; D020869:Gene Expression Profiling; D020022:Genetic Predisposition to Disease; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods; D012890:Sleep / Q000235:genetics / Q000502:physiology*; D012893:Sleep Wake Disorders / Q000235:genetics / Q000503:physiopathology*