[Association of mineral and bone disorder with increasing PWV in CKD 1-5 patients].
The association between pulse wave velocity(PWV) and chronic kidney disease mineral and bone disorder(CKD-MBD) was investigated in CKD 1-5 patients without dialysis. Pulse pressure(PP), PWV, serum Cr, non-HDL-cholesterol, Alb, Ca, Pi, calcitriol, intact-PTH and BAP were measured in sixty patients not receiving a phosphate binder or vitamin D. Using the relationship between age and baPWV in healthy subjects, we determined delta baPWV(measured baPWV-calculated baPWV) as an index for the effect of CKD-related factors. delta baPWV was significantly higher in diabetic patients (p < 0.00001). Simple regression analysis revealed that delta baPWV was positively correlated with PP (p < 0.05) and Log(intact-PTH) (p < 0.01), but negatively correlated with Log(estimated GFR) and Log(calcitriol) (p < 0.01). Multiple regression analysis revealed that delta baPWV was significantly associated with PP and calcitriol, or PP and intact-PTH. These results suggest a relationship between PWV and CKD-MBD.
Shiota
Jun
J
Department of Internal Medicine, Urayasu-Ichikawa City Hospital, Chiba, Japan.
Watanabe
Mitsuhiro
M
D000368:Aged; D001783:Blood Flow Velocity; D015519:Bone Density; D001851:Bone Diseases, Metabolic / Q000378:metabolism / Q000503:physiopathology*; D002784:Cholesterol / Q000097:blood; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D008903:Minerals / Q000378:metabolism*; D011673:Pulsatile Flow
D008903:Minerals; D002784:Cholesterol