title: Mutations in 16S rRNA and ribosomal protein S5 associated with high-level spectinomycin resistance in Pasteurella multocida.
abstract: Pasteurella multocida isolates with high-level spectinomycin resistance in which no adenyltransferase genes could be demonstrated exhibited a C1192G transversion in the 16S rRNA of all six or five of the six rRNA operons and/or two different types of 3-bp deletions in the rpsE gene that codes for the ribosomal protein S5.
authors: Institut für Tierzucht, Bundesforschungsanstalt für Landwirtschaft (FAL), Höltystr. 10, 31535 Neustadt-Mariensee, Germany.
authors: Corinna
authors: C
authors: Kehrenberg
authors: Stefan
authors: S
authors: Schwarz
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001483:Base Sequence; D002417:Cattle; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D009154:Mutation; D016979:Pasteurella multocida / Q000187:drug effects* / Q000235:genetics; D012336:RNA, Ribosomal, 16S / Q000235:genetics*; D012269:Ribosomal Proteins / Q000235:genetics*; D000198:Spectinomycin / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D012336:RNA, Ribosomal, 16S; D012269:Ribosomal Proteins; C030831:ribosomal protein S5; D000198:Spectinomycin