Application of nicotine enantiomers, derivatives and analogues in therapy of neurodegenerative disorders.
This review gives a brief overview over the major aspects of application of the nicotine alkaloid and its close derivatives in the therapy of some neurodegenerative disorders and diseases (e.g. Alzheimer's disease, Parkinson's disease, Tourette's syndrome, schizophrenia etc.). The issues concerning methods of nicotine analysis and isolation, and some molecular aspects of nicotine pharmacology are included. The natural and synthetic analogues of nicotine that are considered for medical practice are also mentioned. The molecular properties of two naturally occurring nicotine enantiomers are compared--the less-common but less-toxic (R)-nicotine is suggested as a natural compound that may find its place in pharmaceutical practice.
Pogocki
Dariusz
D
Rzeszów University of Technology, Faculty of Chemistry, Department of Biochemistry and Biotechnology, 6 Powstańców Warszawy Ave. 35-959 Rzeszów, Poland.
Ruman
Tomasz
T
Danilczuk
Magdalena
M
Danilczuk
Marek
M
Celuch
Monika
M
Wałajtys-Rode
Elzbieta
E
D000818:Animals; D015507:Drugs, Investigational / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D007536:Isomerism; D019636:Neurodegenerative Diseases / Q000188:drug therapy* / Q000378:metabolism; D009538:Nicotine / Q000031:analogs & derivatives / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D018722:Nicotinic Agonists / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D011978:Receptors, Nicotinic / Q000187:drug effects / Q000378:metabolism; D013678:Technology, Pharmaceutical / Q000379:methods; D014026:Nicotiana / Q000737:chemistry
D015507:Drugs, Investigational; D018722:Nicotinic Agonists; D011978:Receptors, Nicotinic; D009538:Nicotine