Renal ischemia-reperfusion injury: renal dendritic cells loudly sound the alarm.
Renal ischemia-reperfusion injury is a major cause of acute renal failure and kidney allograft dysfunction. Dong and colleagues now identify the surveying renal dendritic cell network as the predominant source of tumor necrosis factor-alpha during the early stages of renal ischemia-reperfusion injury, raising the possibility for direct targeting of renal dendritic cells to help ameliorate this common form of renal injury and its sequelae.
Nelson
P J
PJ
Division of Nephrology, New York University School of Medicine, New York, New York, USA.
D003713:Dendritic Cells / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D007668:Kidney / Q000098:blood supply*; D015427:Reperfusion Injury / Q000209:etiology*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D014409:Tumor Necrosis Factor-alpha