Racial/ethnic differences in the monthly variation of preeclampsia incidence.
OBJECTIVE
The purpose of this study was to assess monthly patterns in preeclampsia risk separately by race/ethnicity.


METHODS
We conducted a cohort study of 20,794 white women and 18,916 black women who received care at 12 hospitals in the United States.


RESULTS
Among white women, there was a significant U-shaped trend in the incidence of preeclampsia: the incidence was highest in winter months, reached its nadir in mid August, and subsequently increased through the fall months (P < .05). When compared with occurrences in January, the adjusted odds ratios were 0.65 (0.43, 0.99) for May, 0.76 (95% CI, 0.51, 1.13) for June, 0.64 (95% CI, 0.43, 0.97) for July, and 0.64 (95% CI, 0.42, 0.96) for August. Among black women, there was no association between month of delivery and preeclampsia risk (P = .81).


CONCLUSIONS
Our finding that the incidence of preeclampsia decreases in white women during the summer months and that no pattern exists in black women suggests that, in each subgroup, different or competing environmental exposures may be important for the pathogenesis of preeclampsia.
Bodnar
Lisa M
LM
Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA.
Catov
Janet M
JM
Roberts
James M
JM
D000328:Adult; D001741:Black or African American / Q000706:statistics & numerical data*; D000367:Age Factors; D015331:Cohort Studies; D016001:Confidence Intervals; D005006:Ethnicity / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D015994:Incidence; D016017:Odds Ratio; D010507:Periodicity; D011225:Pre-Eclampsia / Q000175:diagnosis / Q000208:ethnology*; D011247:Pregnancy; D011336:Probability; D018570:Risk Assessment; D012621:Seasons; D012720:Severity of Illness Index; D014481:United States / Q000453:epidemiology; D044465:White People / Q000706:statistics & numerical data*