title: Successful use of extracorporeal membrane oxygenation in severe necrotizing pneumonia caused by Staphylococcus aureus.
abstract: OBJECTIVE
  To report the successful use of extracorporeal membrane oxygenation (ECMO) as rescue therapy for severe necrotizing pneumonia secondary to infection by the Staphylococcus aureus species.
  
  
  METHODS
  Case series.
  
  
  METHODS
  Pediatric intensive care unit at a freestanding tertiary care children's hospital.
  
  
  METHODS
  Two pediatric patients with severe S. aureus-induced necrotizing pneumonia requiring rescue with ECMO. Both patients survived with good neurologic outcomes. One patient required the use of activated factor VII for severe bleeding while on ECMO, with no thrombotic effect on the ECMO circuit.
  
  
  CONCLUSIONS
  ECMO as rescue support should be considered in a timely fashion for refractory hypoxemic respiratory failure resulting from S. aureus pneumonia, including patients with necrotizing pneumonia. Use of ECMO support in such cases, coupled with aggressive measures aimed at minimizing bleeding, such as the use of activated factor VII, may result in excellent short- and long-term outcomes for such patients.
authors.affiliation: Department of Pediatrics, University of Arkansas for Medical Sciences, Arkansas Children's Hospital, Little Rock, AR 72202, USA. stroudmichaelh@uams.edu
authors.forename: Michael H
authors.initials: MH
authors.lastname: Stroud
authors.forename: Regina
authors.initials: R
authors.lastname: Okhuysen-Cawley
authors.forename: Robert
authors.initials: R
authors.lastname: Jaquiss
authors.forename: Ariel
authors.initials: A
authors.lastname: Berlinski
authors.forename: Richard T
authors.initials: RT
authors.lastname: Fiser
mesh_terms: D000293:Adolescent; D002648:Child; D015199:Extracorporeal Membrane Oxygenation; D006801:Humans; D008297:Male; D009336:Necrosis; D011023:Pneumonia, Staphylococcal / Q000150:complications / Q000473:pathology; D012131:Respiratory Insufficiency / Q000209:etiology / Q000628:therapy*