title: Selective mastectomy in the management of locally advanced breast cancer.
abstract: OBJECTIVE
  To evaluate local control for patients with locally advanced noninflammatory breast cancer (LABC) managed by selective mastectomy.
  
  
  METHODS
  Between 1979 and 1996, 176 patients with LABC were prospectively managed by chemotherapy (CT)-irradiation (RT)-CT without routine mastectomy. All surviving patients were followed for a minimum of 5 years.
  
  
  RESULTS
  A total of 132 patients (75%) had a T4 tumor and 22 (12.5%) supraclavicular nodal disease. The clinical complete response rate was 91% (160/176), which included 13 patients who underwent mastectomy and 2 an iridium wire implant. The first site of failure was local for 43 patients (breast +/- axilla for 38); 27 of these patients underwent salvage mastectomy and 11 did not for an overall mastectomy rate of 23% (40/176). If all 176 patients had undergone routine mastectomy (136 extra mastectomies), 11 additional patients may have avoided an unsalvageable first local relapse. The others would have either have not had a local relapse or would have suffered local relapse after distant disease. No tumor or treatment related factor was found to predict local disease at death. Median disease-free and overall survival for all patients was 26 and 52 months, respectively.
  
  
  CONCLUSIONS
  Selective mastectomy in LABC may not jeopardize local control or survival.
authors.affiliation: Department of Radiation Oncology, Westmead Hospital, NSW 2145, Sydney, Australia. verity.ahern@awahs.healthnsw.gov.au
authors.forename: Verity
authors.initials: V
authors.lastname: Ahern
authors.forename: John
authors.initials: J
authors.lastname: Boyages
authors.forename: Val
authors.initials: V
authors.lastname: Gebski
authors.forename: Dominic
authors.initials: D
authors.lastname: Moon
authors.forename: Nicholas
authors.initials: N
authors.lastname: Wilcken
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008408:Mastectomy / Q000379:methods*; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000473:pathology / Q000601:surgery; D011446:Prospective Studies; D012074:Remission Induction; D012189:Retrospective Studies; D016019:Survival Analysis