title: Cardiovascular response to renin substrate microinjection into the central nucleus of the amygdala of rats.
abstract: Central nucleus of the amygdala is involved in cardiovascular regulation. Although most components of the renin-angiotensin system have been found to be distributed in amygdala, renin expression in brain has remained controversial. This work was undertaken to elucidate the extent of renin presence in this nucleus. A cannula was implanted bilaterally into the central nucleus of the amygdala. Mean arterial pressure and heart rate were directly measured via indwelling femoral artery cannula post bilateral intra central nucleus of the amygdala microinjection of renin substrate. Renin substrate microinjection dose-dependently increased mean arterial pressure and heart rate, whereas captopril, saralasin and losartan pretreatment inhibited these effects. The results suggest the presence of local renin or similar proteases in this nucleus.
authors.affiliation: Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran.
authors.forename: Behnam
authors.initials: B
authors.lastname: Heshmatian
authors.forename: Mohsen
authors.initials: M
authors.lastname: Parviz
authors.forename: Sayed Morteza
authors.initials: SM
authors.lastname: Karimian
authors.forename: Mansoor
authors.initials: M
authors.lastname: Keshavarz
authors.forename: Hamid
authors.initials: H
authors.lastname: Sohanaki
mesh_terms: D000679:Amygdala / Q000187:drug effects / Q000378:metabolism*; D000808:Angiotensinogen / Q000008:administration & dosage* / Q000378:metabolism; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002319:Cardiovascular System / Q000187:drug effects* / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D006339:Heart Rate / Q000187:drug effects; D007276:Injections, Intraventricular; D008297:Male; D008845:Microinjections; D051381:Rats; D017207:Rats, Sprague-Dawley; D012083:Renin / Q000378:metabolism; D015842:Serine Proteinase Inhibitors / Q000008:administration & dosage* / Q000378:metabolism
chemical_list: D015842:Serine Proteinase Inhibitors; D000808:Angiotensinogen; D012083:Renin