Inhibitory effects of caffeine on hippocampal neurogenesis and function.
Caffeine is one of the most extensively consumed psychostimulants in the world. However, compared to short-term effects of caffeine, the long-term effects of caffeine consumption on learning and memory are poorly characterized. The present study found that long-term consumption of low dose caffeine (0.3 g/L) slowed hippocampus-dependent learning and impaired long-term memory. Caffeine consumption for 4 weeks also significantly reduced hippocampal neurogenesis compared to controls. From these results, we concluded that long-term consumption of caffeine could inhibit hippocampus-dependent learning and memory partially through inhibition of hippocampal neurogenesis.
Han
Myoung-Eun
ME
Department of Anatomy, School of Medicine, Pusan National University, 1-10 Ami-Dong, Seo-Gu, Pusan 602-739, Republic of Korea.
Park
Kyu-Hyun
KH
Baek
Sun-Yong
SY
Kim
Bong-Seon
BS
Kim
Jae-Bong
JB
Kim
Hak-Jin
HJ
Oh
Sae-Ock
SO
D000818:Animals; D002110:Caffeine / Q000008:administration & dosage*; D049109:Cell Proliferation / Q000187:drug effects; D006624:Hippocampus / Q000166:cytology* / Q000187:drug effects / Q000502:physiology*; D018782:Maze Learning / Q000187:drug effects*; D009433:Neural Inhibition / Q000187:drug effects* / Q000502:physiology; D009474:Neurons / Q000166:cytology* / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D002110:Caffeine