title: Protective effects of amylin on reserpine-induced gastric damage in the rat.
abstract: Here we show that the vasoactive peptide amylin protects against reserpine-induced gastric injury in the rat, resulting in lower score of gastric lesions. Hepatocyte growth factor (HGF), its c-Met receptor and cyclooxygenase-2 (COX-2) expression, usually increased in course of reserpine-induced gastric damage, was decreased in rats treated with amylin. Pretreatment with the specific amylin receptor antagonist AC187 abrogated the gastroprotective effects of amylin and restored high expression levels of HGF, c-Met and COX-2. Our data suggest that protective effects of amylin upon the gastric mucosa are specific and eventually involve modulation of HGF, c-Met and COX-2 expression.
authors.affiliation: Department of Experimental and Clinical Pharmacology, School of Medicine, University of Catania, Italy.
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Cantarella
authors.forename: Giuseppa
authors.initials: G
authors.lastname: Martinez
authors.forename: Giulia
authors.initials: G
authors.lastname: Di Benedetto
authors.forename: Carla
authors.initials: C
authors.lastname: Loreto
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Musumeci
authors.forename: Agata
authors.initials: A
authors.lastname: Prato
authors.forename: Laurence
authors.initials: L
authors.lastname: Lempereur
authors.forename: Mario
authors.initials: M
authors.lastname: Matera
authors.forename: Matilde
authors.initials: M
authors.lastname: Amico-Roxas
authors.forename: Renato
authors.initials: R
authors.lastname: Bernardini
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Clementi
mesh_terms: D000682:Amyloid / Q000494:pharmacology*; D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology; D015153:Blotting, Western; D051546:Cyclooxygenase 2 / Q000378:metabolism; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D017228:Hepatocyte Growth Factor / Q000378:metabolism; D058228:Islet Amyloid Polypeptide; D048670:MAP Kinase Kinase 4 / Q000378:metabolism; D008297:Male; D010446:Peptide Fragments / Q000494:pharmacology; D010766:Phosphorylation / Q000187:drug effects; D019859:Proto-Oncogene Proteins c-met / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D058287:Receptors, Islet Amyloid Polypeptide; D018000:Receptors, Peptide / Q000037:antagonists & inhibitors; D012110:Reserpine / Q000633:toxicity*; D013276:Stomach Ulcer / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*
chemical_list: D000682:Amyloid; D000897:Anti-Ulcer Agents; D058228:Islet Amyloid Polypeptide; D010446:Peptide Fragments; D058287:Receptors, Islet Amyloid Polypeptide; D018000:Receptors, Peptide; C087166:AC 187; D017228:Hepatocyte Growth Factor; D012110:Reserpine; D051546:Cyclooxygenase 2; D019859:Proto-Oncogene Proteins c-met; D048670:MAP Kinase Kinase 4