Accrual of organ damage over time in Argentine patients with systemic lupus erythematosus: a multi-centre study.
The goals of this study were to ascertain damage in patients with systemic lupus erythematosus (SLE) from five rheumatologic centres in Argentina and to examine overall damage, damage by domain and damage by item within each domain. We performed a retrospective observational study including patients with SLE (ACR 1997 revised and modified criteria) from five rheumatology centres in Argentina. Organ damage was scored using the SLICC/ACR DI (SDI), ascertained at years 1, 2, 5 and 10. Three centres provided information up to the fifth year. Of the 197 patients, 88.3% were women and their mean age was 33.2 years. The mean disease duration and follow-up were 7.6 and 5.3 years, respectively. Damage accrued gradually over time with SDI ranging from 0.52 (+/-1.1) at year 1 up to 2.46 (+/-2.1) at year 10. The renal system was the most involved system, followed by the neuropsychiatric, the cardiovascular and the musculoskeletal systems. Proteinuria, cognitive impairment, pericarditis, avascular necrosis, cataract and alopecia were the predominant items in their respective systems. Systems such as peripheral vascular, pulmonary, gastrointestinal, diabetes, malignancy and premature gonadal failure were not frequent. Overall SDI had a gradual increase over time. Damage in each domain of SDI, except for diabetes, had a similar behaviour. Behaviour of items in each domain varied.
Cassano
Gustavo
G
Rheumatology Section, Department of Internal Medicine, Hospital J.M. Cullen, Av Freyre 2150, Santa Fe, Argentina.
Roverano
Susana
S
Rheumatology Section, Department of Internal Medicine, Hospital J.M. Cullen, Av Freyre 2150, Santa Fe, Argentina.
Paira
Sergio
S
Rheumatology Section, Department of Internal Medicine, Hospital J.M. Cullen, Av Freyre 2150, Santa Fe, Argentina. pairasergio@fibertel.com.ar.
Bellomio
Verónica
V
Rheumatology Section, Department of Internal Medicine, Hospital Padilla, Tucumán, Argentina.
Lucero
Eleonora
E
Rheumatology Section, Department of Internal Medicine, Hospital Padilla, Tucumán, Argentina.
Berman
Alberto
A
Rheumatology Section, Department of Internal Medicine, Hospital Padilla, Tucumán, Argentina.
Spindler
Alberto
A
Rheumatology Section, Department of Internal Medicine, Hospital Padilla, Tucumán, Argentina.
Trobo
Rosana
R
Rheumatology Section, Hospital Municipal Nuestra Señora de Luján, Lujan, Buenos Aires, Argentina.
Somma
Luis Fernando
LF
Rheumatology Section, Hospital Nuestra Señora de Luján, Luján, Buenos Aires, Argentina.
Graf
César
C
Hospital San Martín, Paraná, Entre Ríos, Argentina.
Barrionuevo
Alejandra
A
Rheumatology Section, Department of Internal Medicine, Hospital Tornú, Buenos Aires, Argentina.
Papasidero
Silvia
S
Rheumatology Section, Department of Internal Medicine, Hospital Tornú, Buenos Aires, Argentina.
Rillo
Oscar
O
Rheumatology Section, Department of Internal Medicine, Hospital Tornú, Buenos Aires, Argentina.
D000328:Adult; D001118:Argentina / Q000453:epidemiology; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000453:epidemiology* / Q000503:physiopathology; D008297:Male; D012189:Retrospective Studies; D012720:Severity of Illness Index; D015996:Survival Rate; D013997:Time Factors