title: Salivaricin P, one of a family of two-component antilisterial bacteriocins produced by intestinal isolates of Lactobacillus salivarius.
abstract: Lactobacillus salivarius DPC6005, a porcine intestinal isolate, produces a two-component bacteriocin, salivaricin P, with homology to ABP-118 produced by a human probiotic L. salivarius strain. Indeed, molecular characterization revealed that while the peptides Sln1 and ABP-118alpha are identical, their companion peptides (Sln2 and ABP-118beta, respectively) differ by two amino acids. This observation suggests that two-component bacteriocins may be a common feature of intestinal L. salivarius strains.
authors.affiliation: Teagasc Biotechnology Centre, Moorepark Food Research Centre, Fermoy, Co. Cork, Ireland.
authors.forename: Eoin
authors.initials: E
authors.lastname: Barrett
authors.forename: Maria
authors.initials: M
authors.lastname: Hayes
authors.forename: Paula
authors.initials: P
authors.lastname: O'Connor
authors.forename: Gillian
authors.initials: G
authors.lastname: Gardiner
authors.forename: Gerald F
authors.initials: GF
authors.lastname: Fitzgerald
authors.forename: Catherine
authors.initials: C
authors.lastname: Stanton
authors.forename: R Paul
authors.initials: RP
authors.lastname: Ross
authors.forename: Colin
authors.initials: C
authors.lastname: Hill
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000737:chemistry / Q000494:pharmacology; D000898:Antibiosis; D001430:Bacteriocins / Q000096:biosynthesis* / Q000737:chemistry / Q000235:genetics* / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D007422:Intestines / Q000382:microbiology*; D007778:Lactobacillus / Q000302:isolation & purification / Q000502:physiology*; D008087:Listeria / Q000187:drug effects; D008969:Molecular Sequence Data; D017386:Sequence Homology, Amino Acid; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D013552:Swine
chemical_list: C459788:ABP-118 protein, Lactobacillus salivarius; D000900:Anti-Bacterial Agents; D001430:Bacteriocins