title: Preservation of integron types among Enterobacteriaceae producing extended-spectrum beta-lactamases in a Spanish hospital over a 15-year period (1988 to 2003).
abstract: The variable presence of integrons among extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae species (0 to 66%) is described. Association between bla(ESBL) and integrons occurred when these are linked to specific ESBL-type genes (In60 bearing ISCR1 and bla(CTX-M-9)) or when ESBL genes were superimposed onto selected plasmids carrying integrons. Some integrons were identical to those found during decades worldwide, illustrating the preservation of the genetic elements carrying them.
authors.affiliation: Servicio de Microbiología, Hospital Universitario Ramón y Cajal. Carretera de Colmenar, km. 9.1. Madrid 28034, Spain.
authors.forename: Elisabete
authors.initials: E
authors.lastname: Machado
authors.forename: Joana
authors.initials: J
authors.lastname: Ferreira
authors.forename: Angela
authors.initials: A
authors.lastname: Novais
authors.forename: Luísa
authors.initials: L
authors.lastname: Peixe
authors.forename: Rafael
authors.initials: R
authors.lastname: Cantón
authors.forename: Fernando
authors.initials: F
authors.lastname: Baquero
authors.forename: Teresa M
authors.initials: TM
authors.lastname: Coque
mesh_terms: D004755:Enterobacteriaceae / Q000145:classification / Q000187:drug effects / Q000201:enzymology* / Q000235:genetics*; D004756:Enterobacteriaceae Infections / Q000453:epidemiology* / Q000382:microbiology; D006761:Hospitals; D006801:Humans; D032023:Integrons; D008826:Microbial Sensitivity Tests; D010957:Plasmids / Q000235:genetics; D013030:Spain / Q000453:epidemiology; D018440:beta-Lactam Resistance; D001618:beta-Lactamases / Q000096:biosynthesis* / Q000145:classification / Q000235:genetics
chemical_list: D001618:beta-Lactamases