title: Risk of cervical intraepithelial neoplasia grade 2 or 3 after loop electrosurgical excision procedure associated with human papillomavirus type 16 variants.
abstract: Identification of factors associated with risk of relapse after treatment for high-grade cervical intraepithelial neoplasia (CIN) has important clinical implications. Study subjects were women participating in the Atypical Squamous Cells of Undetermined Significance and Low-Grade Squamous Intraepithelial Lesion Triage Study who were treated for CIN3 by loop electrosurgical excision procedure (LEEP) and who had a baseline infection with human papillomavirus type 16 (HPV16). These women were followed every 6 months for 2 years. Post-LEEP CIN2-3 was found in 20 (10.0%) of the 201 women. An adjusted relative risk of 3.1 (95% confidence interval, 1.1-8.9) was associated with HPV16 non-European, compared with European, variants, a finding that is consistent with the variant-related risk of prevalent/incident high-grade CIN.
authors.affiliation: Department of Pathology, School of Medicine, University of Washington, Seattle, WA 98103, USA. longfu@u.washington.edu
authors.forename: Long Fu
authors.initials: LF
authors.lastname: Xi
authors.forename: Nancy B
authors.initials: NB
authors.lastname: Kiviat
authors.forename: Cosette M
authors.initials: CM
authors.lastname: Wheeler
authors.forename: Aimee
authors.initials: A
authors.lastname: Kreimer
authors.forename: Jesse
authors.initials: J
authors.lastname: Ho
authors.forename: Laura A
authors.initials: LA
authors.lastname: Koutsky
mesh_terms: D003127:Colposcopy; D018572:Disease-Free Survival; D004598:Electrosurgery; D005260:Female; D052162:Human papillomavirus 16 / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology* / Q000473:pathology / Q000601:surgery / Q000821:virology; D009367:Neoplasm Staging; D030361:Papillomavirus Infections / Q000453:epidemiology* / Q000473:pathology / Q000601:surgery / Q000821:virology; D016016:Proportional Hazards Models; D012307:Risk Factors; D014481:United States / Q000453:epidemiology; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology* / Q000473:pathology / Q000601:surgery / Q000821:virology; D002578:Uterine Cervical Dysplasia / Q000453:epidemiology* / Q000473:pathology / Q000601:surgery / Q000821:virology