[The effect of amino acid nutritional support on serum tryptophan and melatonin in lung cancer patients receiving chemotherapy].
OBJECTIVE
To investigate the effect of amino acid parenteral nutritional (PN) support on serum tryptophan and melatonin in non-small cell lung cancer (NSCLC) patients receiving chemotherapy.


METHODS
Seventy-two patients with inoperable NSCLC were divided into three groups randomly: control group, 250 ml/d amino acids PN therapy group and 500 ml/d amino acids PN therapy group. The same NP (cisplatin + vinorelbine) chemotherapy was carried out in all the three groups. During three sessions of chemotherapy,amino acids PN therapy was given to the amino acids PN therapy groups. Serum tryptophan and melatonin concentration changes were assessed before and after chemotherapy.


RESULTS
After chemotherapy the concentration of MT and Try were much lower than that before chemotherapy in the three group patients (P < 0.05). But the concentration of MT and Try in the PN group patients was higher than that in control group patients. The concentration of MT and Try in the 500 ml/d amino acid parenteral nutritional support group patients were significantly higher than that in the 250 ml/d group patients, the difference was significant (P < 0.05).


CONCLUSIONS
Amino acid parenteral nutritional support is beneficial to improve the lower concentration of serum MT and Try in NSCLC patients receiving chemotherapy, and a more significant effect can be achieved by the 500 ml/d amino acid parenteral nutritional support treatment.
Yin
Shi
S
Department of Geriatrics, Anhui Provincial Hospital, Hefei 230001, China.
Hu
Shi-lian
SL
Shen
Gan
G
Wang
Wei-dong
WD
Hu
Bing
B
Xu
Wei-ping
WP
Wang
Hua
H
Zhang
Qi
Q
D000368:Aged; D000596:Amino Acids / Q000008:administration & dosage / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002289:Carcinoma, Non-Small-Cell Lung / Q000097:blood / Q000188:drug therapy / Q000628:therapy*; D002945:Cisplatin / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000628:therapy*; D008297:Male; D008550:Melatonin / Q000097:blood*; D009367:Neoplasm Staging; D010288:Parenteral Nutrition; D016896:Treatment Outcome; D014364:Tryptophan / Q000097:blood*; D014747:Vinblastine / Q000008:administration & dosage / Q000031:analogs & derivatives; D000077235:Vinorelbine
D000596:Amino Acids; D014747:Vinblastine; D014364:Tryptophan; D008550:Melatonin; D002945:Cisplatin; D000077235:Vinorelbine