The GLUT4 glucose transporter.
Few physiological parameters are more tightly and acutely regulated in humans than blood glucose concentration. The major cellular mechanism that diminishes blood glucose when carbohydrates are ingested is insulin-stimulated glucose transport into skeletal muscle. Skeletal muscle both stores glucose as glycogen and oxidizes it to produce energy following the transport step. The principal glucose transporter protein that mediates this uptake is GLUT4, which plays a key role in regulating whole body glucose homeostasis. This review focuses on recent advances on the biology of GLUT4.
Huang
Shaohui
S
Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.
Czech
Michael P
MP
D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D005786:Gene Expression Regulation; D005947:Glucose / Q000378:metabolism; D051275:Glucose Transporter Type 4 / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D006706:Homeostasis; D006801:Humans; D008856:Microscopy, Fluorescence; D008954:Models, Biological; D021381:Protein Transport; D015398:Signal Transduction / Q000502:physiology
D051275:Glucose Transporter Type 4; D005947:Glucose