Synthesis and biological evaluation of diamine-based histamine H3 antagonists with serotonin reuptake inhibitor activity.
The synthesis and structure-activity relationships of a series of novel phenoxyphenyl diamine derivatives with affinity for both the histamine H(3) receptor and the serotonin transporter is described.
Stocking
Emily M
EM
Johnson & Johnson Pharmaceutical Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA 92121, USA. estockin@prdus.jnj.com
Miller
Jennifer M
JM
Barbier
Ann J
AJ
Wilson
Sandy J
SJ
Boggs
Jamin D
JD
McAllister
Heather M
HM
Wu
Jiejun
J
Lovenberg
Timothy W
TW
Carruthers
Nicholas I
NI
Wolin
Ronald L
RL
D003959:Diamines / Q000737:chemistry*; D006633:Histamine Antagonists / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D015394:Molecular Structure; D018100:Receptors, Histamine H3 / Q000737:chemistry / Q000187:drug effects*; D017367:Selective Serotonin Reuptake Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D003959:Diamines; D006633:Histamine Antagonists; D018100:Receptors, Histamine H3; D017367:Selective Serotonin Reuptake Inhibitors