title: Diagnosis of maxillofacial tumor with L-3-[18f]-fluoro-alpha-methyltyrosine (FMT) PET: a comparative study with FDG-PET.
abstract: OBJECTIVE
  To compare L-3-[18F]-fluoro-a-methyltyrosine (FMT)-positron emission tomography (PET) and 2-[18F]-fluoro-2-deoxy-D-glucose (FDG)-PET in the differential diagnosis of maxillofacial tumors.
  
  
  METHODS
  This study included 36 patients (16 males, 20 females; 31-90 years old) with untreated malignant tumors (34 squamous cell carcinoma, one mucoepidermoid carcinoma, one rhabdomyosarcoma) and seven patients (five males, two females; 32-81 years old) with benign lesions. In all patients, both FMT-PET and FDG-PET were performed within two weeks before biopsy or treatment of the lesions. To evaluate the diagnostic usefulness of FMT-PET and FDG-PET, visual interpretation and semiquantitative analysis were performed. PET images were rated according to the contrast of tumor uptake as compared with background, and were statistically analyzed. As a semiquantitative analysis, standardized uptake values (SUV) of the primary tumors were measured, and the SUV data were analyzed using receiver operating characteristic (ROC) curves.
  
  
  RESULTS
  The mean SUV of the malignant lesions were significantly higher than those of the benign lesions in both FMT-PET (2.62 +/- 1.58 vs. 1.20 +/- 0.30, p < 0.01) and FDG-PET (9.17 +/- 5.06 vs. 3.14 +/- 1.34, p < 0.01). A positive correlation (r = 0.567, p < 0.0001, n = 46) was noted between FMT and FDG. ROC analysis revealed that there was no statistically significant difference in SUVs between FMT and FDG for differentiating malignant tumors. In 27 of 36 patients, FMT-PET had better contrast of malignant tumor visualization to the surrounding normal structures by visual assessment (p < 0.005, binomial proportion test).
  
  
  CONCLUSIONS
  Differential diagnosis of FMT-PET based on the uptake in maxillofacial tumors is equivalent to FDG-PET. However, the contrast of FMT uptake between maxillofacial tumors and the surrounding normal structures is higher than that of FDG, indicating the possibility of accurate diagnosis of maxillofacial tumors by FMT-PET.
authors.affiliation: Department of Stomatology and Maxillofacial Surgery, Gunma University Graduate School of Medicine, Japan.
authors.forename: Mitsuyuki
authors.initials: M
authors.lastname: Miyakubo
authors.forename: Noboru
authors.initials: N
authors.lastname: Oriuchi
authors.forename: Yoshito
authors.initials: Y
authors.lastname: Tsushima
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Higuchi
authors.forename: Keiko
authors.initials: K
authors.lastname: Koyama
authors.forename: Kiyokazu
authors.initials: K
authors.lastname: Arai
authors.forename: Bishnuhari
authors.initials: B
authors.lastname: Paudyal
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Iida
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Hanaoka
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Ishikita
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Nakasone
authors.forename: Akihide
authors.initials: A
authors.lastname: Negishi
authors.forename: Kenji
authors.initials: K
authors.lastname: Mogi
authors.forename: Keigo
authors.initials: K
authors.lastname: Endo
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000473:pathology*; D005153:Facial Neoplasms / Q000000981:diagnostic imaging*; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007573:Jaw Neoplasms / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014443:Tyrosine / Q000031:analogs & derivatives*
chemical_list: C493093:O-(18F)fluoromethyl-L-tyrosine; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D014443:Tyrosine