Constituents of the cultivated mulberry tree.
In addition to mulberrofuran C, a new 2-arylbenzofuran derivative, six flavonoid derivatives, cyclomorusin, morusin, kuwanon C, E, G and H, as well as a known 2-arylbenzofuran derivative, chalcomoracin, were isolated from extracts of root bark of the cultivated mulberry tree (a variety of Morus bombycis K OIDZUMI). The structure of mulberrofuran C was shown to be VIII on the basis of spectral data. It is regarded biogenetically as a Diels-Alder adduct of a chalcone derivative and a dehydroprenyl 2-arylbenzofuran derivative. Intravenous injection of mulberrofuran C produced significant hypotension in rabbit.
Nomura
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Faculty of Pharmaceutical Sciences, Toho University, Funabashi, Chiba, Japan.
Fukai
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Matsumoto
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Ohmori
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