title: Comparison of the effects of firocoxib, carprofen and vedaprofen in a sodium urate crystal induced synovitis model of arthritis in dogs.
abstract: A randomized, placebo-controlled, four-period cross-over laboratory study involving eight dogs was conducted to confirm the effective analgesic dose of firocoxib, a selective COX-2 inhibitor, in a synovitis model of arthritis. Firocoxib was compared to vedaprofen and carprofen, and the effect, defined as a change in weight bearing measured via peak ground reaction, was evaluated at treatment dose levels. A lameness score on a five point scale was also assigned to the affected limb. Peak vertical ground reaction force was considered to be the most relevant measurement in this study. The firocoxib treatment group performed significantly better than placebo at the 3 h post-treatment time point and significantly better than placebo and carprofen at the 7 h post-treatment time point. Improvement in lameness score was also significantly better in the dogs treated with firocoxib than placebo and carprofen at both the 3 and 7 h post-treatment time points.
authors.affiliation: Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, P.O. Box 80.154, 3508 TD Utrecht, The Netherlands. H.A.W.Hazewinkel@vet.uu.nl
authors.forename: Herman A W
authors.initials: HA
authors.lastname: Hazewinkel
authors.forename: Walter E
authors.initials: WE
authors.lastname: van den Brom
authors.forename: Lars F H
authors.initials: LF
authors.lastname: Theyse
authors.forename: Matthias
authors.initials: M
authors.lastname: Pollmeier
authors.forename: Peter D
authors.initials: PD
authors.lastname: Hanson
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D001168:Arthritis / Q000139:chemically induced / Q000188:drug therapy / Q000662:veterinary*; D002227:Carbazoles / Q000627:therapeutic use*; D018592:Cross-Over Studies; D004283:Dog Diseases / Q000139:chemically induced / Q000188:drug therapy*; D004285:Dogs; D005260:Female; D007794:Lameness, Animal / Q000139:chemically induced / Q000188:drug therapy; D008297:Male; D009281:Naphthalenes / Q000627:therapeutic use*; D011422:Propionates / Q000627:therapeutic use*; D013450:Sulfones / Q000627:therapeutic use*; D013585:Synovitis / Q000139:chemically induced / Q000188:drug therapy / Q000662:veterinary*; D013997:Time Factors; D014527:Uric Acid
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D002227:Carbazoles; D009281:Naphthalenes; D011422:Propionates; D013450:Sulfones; D014527:Uric Acid; C007005:carprofen; C121784:2-(4-cyclohexyl-1-naphthalenyl)propanoic acid; D015107:4-Butyrolactone; C487384:firocoxib