title: Farnesyl protein transferase and tumor cell growth inhibitory activities of lipiferolide isolated from Liriodendron tulipifera.
abstract: The methanolic extract of the leaves of Liriodendron tulipifera was found to show inhibitory activity towards farnesyl protein transferase (FPTase). Bioassay-guided fractionation of the methanolic extract resulted in the isolation of lipiferolide, an inhibitor of FPTase. This compound inhibited the FPTase activity in a dose-dependent manner, and showed cell growth inhibitory activity against several tumor cells.
authors.affiliation: College of Pharmacy, Woosuk University, Samrye 565-701, Korea.
authors.forename: Mi Kyeong
authors.initials: MK
authors.lastname: Moon
authors.forename: Hyun Mi
authors.initials: HM
authors.lastname: Oh
authors.forename: Byoung-Mog
authors.initials: BM
authors.lastname: Kwon
authors.forename: Nam-In
authors.initials: NI
authors.lastname: Baek
authors.forename: Sung-Hoon
authors.initials: SH
authors.lastname: Kim
authors.forename: Ju Sin
authors.initials: JS
authors.lastname: Kim
authors.forename: Dae Keun
authors.initials: DK
authors.lastname: Kim
mesh_terms: D019883:Alkyl and Aryl Transferases / Q000037:antagonists & inhibitors*; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors / Q000302:isolation & purification / Q000494:pharmacology*; D018922:HL-60 Cells; D006801:Humans; D020014:K562 Cells; D007939:Leukemia L1210; D031567:Liriodendron / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology*; D012717:Sesquiterpenes / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004791:Enzyme Inhibitors; D010936:Plant Extracts; D012717:Sesquiterpenes; C520146:lipiferolide; D019883:Alkyl and Aryl Transferases; C064911:p21(ras) farnesyl-protein transferase