title: [Diagnosis of iron overload].
abstract: Hepatic iron overload conditions can be classified as genetic, mainly related to HFE haemochromatosis, and secondary, mainly associated with haematological and hepatic disorders and with metabolic syndrome. The strict affirmation of iron excess relies upon liver biopsy, MRI or calculation of the amount of iron removed through phlebotomies. Determination of its cause relies upon the assessment of transferrin saturation which, when increased, suggests the diagnosis of either haemochromatosis--implying HFE testing--or overload secondary to dysmyelopoiesis or to end-stage cirrhosis, and, when normal, suggests the diagnosis of dysmetabolic iron overload syndrome.
authors.affiliation: Service des maladies du foie, hôpital CHU Pontchaillou, 35033 Rennes Cedex 9. yves.deugnier@univ-rennes1.fr
authors.forename: Yves
authors.initials: Y
authors.lastname: Deugnier
authors.forename: Yves
authors.initials: Y
authors.lastname: Gandon
authors.forename: Charlotte
authors.initials: C
authors.lastname: Juhel
authors.forename: Damien
authors.initials: D
authors.lastname: Olivié
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Jouanolle
authors.forename: Bruno
authors.initials: B
authors.lastname: Turlin
mesh_terms: D000328:Adult; D000748:Anemia, Macrocytic / Q000150:complications / Q000175:diagnosis; D001706:Biopsy; D006432:Hemochromatosis / Q000175:diagnosis / Q000235:genetics; D006720:Homozygote; D006801:Humans; D019190:Iron Overload / Q000097:blood / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D008099:Liver / Q000473:pathology; D008103:Liver Cirrhosis / Q000150:complications; D008107:Liver Diseases / Q000150:complications / Q000175:diagnosis; D008279:Magnetic Resonance Imaging; D024821:Metabolic Syndrome / Q000150:complications / Q000175:diagnosis; D009154:Mutation; D012806:Siderosis / Q000175:diagnosis; D014168:Transferrin / Q000032:analysis
chemical_list: D014168:Transferrin