title: Multiple regions within 8q24 independently affect risk for prostate cancer.
abstract: After the recent discovery that common genetic variation in 8q24 influences inherited risk of prostate cancer, we genotyped 2,973 SNPs in up to 7,518 men with and without prostate cancer from five populations. We identified seven risk variants, five of them previously undescribed, spanning 430 kb and each independently predicting risk for prostate cancer (P = 7.9 x 10(-19) for the strongest association, and P < 1.5 x 10(-4) for five of the variants, after controlling for each of the others). The variants define common genotypes that span a more than fivefold range of susceptibility to cancer in some populations. None of the prostate cancer risk variants aligns to a known gene or alters the coding sequence of an encoded protein.
authors.affiliation: Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.
authors.forename: Christopher A
authors.initials: CA
authors.lastname: Haiman
authors.forename: Nick
authors.initials: N
authors.lastname: Patterson
authors.forename: Matthew L
authors.initials: ML
authors.lastname: Freedman
authors.forename: Simon R
authors.initials: SR
authors.lastname: Myers
authors.forename: Malcolm C
authors.initials: MC
authors.lastname: Pike
authors.forename: Alicja
authors.initials: A
authors.lastname: Waliszewska
authors.forename: Julie
authors.initials: J
authors.lastname: Neubauer
authors.forename: Arti
authors.initials: A
authors.lastname: Tandon
authors.forename: Christine
authors.initials: C
authors.lastname: Schirmer
authors.forename: Gavin J
authors.initials: GJ
authors.lastname: McDonald
authors.forename: Steven C
authors.initials: SC
authors.lastname: Greenway
authors.forename: Daniel O
authors.initials: DO
authors.lastname: Stram
authors.forename: Loic
authors.initials: L
authors.lastname: Le Marchand
authors.forename: Laurence N
authors.initials: LN
authors.lastname: Kolonel
authors.forename: Melissa
authors.initials: M
authors.lastname: Frasco
authors.forename: David
authors.initials: D
authors.lastname: Wong
authors.forename: Loreall C
authors.initials: LC
authors.lastname: Pooler
authors.forename: Kristin
authors.initials: K
authors.lastname: Ardlie
authors.forename: Ingrid
authors.initials: I
authors.lastname: Oakley-Girvan
authors.forename: Alice S
authors.initials: AS
authors.lastname: Whittemore
authors.forename: Kathleen A
authors.initials: KA
authors.lastname: Cooney
authors.forename: Esther M
authors.initials: EM
authors.lastname: John
authors.forename: Sue A
authors.initials: SA
authors.lastname: Ingles
authors.forename: David
authors.initials: D
authors.lastname: Altshuler
authors.forename: Brian E
authors.initials: BE
authors.lastname: Henderson
authors.forename: David
authors.initials: D
authors.lastname: Reich
mesh_terms: D001741:Black or African American; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics*; D005006:Ethnicity / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D014644:Genetic Variation; D023281:Genomics / Q000379:methods; D005838:Genotype; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D008297:Male; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D011471:Prostatic Neoplasms / Q000235:genetics*; D012307:Risk Factors; D014481:United States; D044465:White People