Assessment of infant brain development with frequency-domain near-infrared spectroscopy.
This is the first report to demonstrate quantitative monitoring of infant brain development with frequency-domain near-infrared spectroscopy (FD-NIRS). Regionally specific increases in blood volume and oxygen consumption were measured in healthy infants during their first year. The results agree with prior PET and SPECT reports; but, unlike these methods, FD-NIRS is portable and uses nonionizing radiation. Further, new information includes the relatively constant tissue oxygenation with age and location, suggesting a tight control between local oxygen delivery and consumption in healthy infants during brain development. FD-NIRS could become the preferred clinical tool for quantitatively assessing infant brain development.
Franceschini
Maria Angela
MA
Athinoula A. Martinos Center, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA. mari@nmr.mgh.harvard.edu
Thaker
Sonal
S
Themelis
George
G
Krishnamoorthy
Kalpathy K
KK
Bortfeld
Heather
H
Diamond
Solomon G
SG
Boas
David A
DA
Arvin
Kara
K
Grant
P Ellen
PE
D001921:Brain / Q000033:anatomy & histology / Q000254:growth & development* / Q000502:physiology*; D002560:Cerebrovascular Circulation; D006801:Humans; D007223:Infant; D008297:Male; D010101:Oxygen Consumption; D012039:Regional Blood Flow; D019265:Spectroscopy, Near-Infrared / Q000379:methods*