title: Noninvasive identification of different intraocular lenses using Raman spectroscopy in porcine eyes.
abstract: OBJECTIVE
  To develop a noninvasive technique for identifying the specific type of intraocular lens (IOL) implanted in porcine eyes.
  
  
  METHODS
  Department of Ophthalmology, University of Ulsan College of Medicine, Asan Medical Center, and Department of Chemistry Education, Seoul National University, Seoul, Korea.
  
  
  METHODS
  A confocal Raman spectroscopy system was used to identify various acrylic (AcrySof SA60AT [Alcon], Sensar AR40e [Advanced Medical Optics], I-Flex [I-Medical Intraocular Lenses]) and silicone (ClariFlex, [Advanced Medical Optics]) IOLs implanted in enucleated pig eyes. Confocal Raman spectra of IOLs were obtained by photoexcitation using the 514.5 nm line from an argon-ion laser, with a power of 1 mW at the sample and an acquisition time of 10 to 100 seconds.
  
  
  RESULTS
  All IOLs, including those composed of acrylic optic material from different manufacturers, exhibited distinct spectral peaks before and after implantation in pig eyes.
  
  
  CONCLUSIONS
  Confocal Raman spectroscopy may represent a novel method for obtaining specific information about implanted IOLs through direct and noninvasive confocal observation of spectral characteristics.
authors.affiliation: Department of Ophthalmology, University of Ulsan College of Medicine, Asan Medical Center, Songpa-Gu, Seoul, Korea.
authors.forename: Jong-uk
authors.initials: JU
authors.lastname: Hwang
authors.forename: Heejeong
authors.initials: H
authors.lastname: Choi
authors.forename: Dae Hong
authors.initials: DH
authors.lastname: Jeong
authors.forename: Myoung Joon
authors.initials: MJ
authors.lastname: Kim
authors.forename: Hungwon
authors.initials: H
authors.lastname: Tchah
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry*; D000818:Animals; D019654:Lens Implantation, Intraocular; D007908:Lens, Crystalline / Q000601:surgery; D007910:Lenses, Intraocular; D013059:Spectrum Analysis, Raman; D013552:Swine
chemical_list: D000180:Acrylic Resins