title: Current concepts in the pathogenesis of nonalcoholic fatty liver disease.
abstract: Nonalcoholic fatty liver disease (NAFLD) is an increasingly recognized cause of chronic liver disease, representing the leading cause of hepatology referral in some centres. However, its pathophysiology is not completely understood. Insulin resistance is one of the major mechanisms involved in disease prevalence and progression. Owing to the lack of an effective pharmacological therapy, recommendations on treatment are scarce and are based mainly on lifestyle changes, including diet and exercise. A review of the current literature on pathogenesis of NAFLD is presented in this article.
authors.affiliation: Department of Biomedical Research, Gastroenterology & Liver Unit, Medica Sur Clinic & Foundation, Mexico City, Mexico. nmendez@medicasur.org.mx
authors.forename: Nahum
authors.initials: N
authors.lastname: Méndez-Sánchez
authors.forename: Marco
authors.initials: M
authors.lastname: Arrese
authors.forename: Daniel
authors.initials: D
authors.lastname: Zamora-Valdés
authors.forename: Misael
authors.initials: M
authors.lastname: Uribe
mesh_terms: D005227:Fatty Acids / Q000378:metabolism; D005234:Fatty Liver / Q000209:etiology*; D006801:Humans; D007333:Insulin Resistance; D008099:Liver / Q000378:metabolism / Q000473:pathology; D053858:Metabolic Networks and Pathways
chemical_list: D005227:Fatty Acids