Docetaxel-induced Meibomian duct inflammation and blockage leading to chalazion formation.
We report a 71-year male with castration-resistant metastatic prostate cancer who was treated with weekly docetaxel for 12 weeks and developed significant eye irritation and dryness during treatment. Subsequently, the patient presented with a lower eyelid mass, which on excision was demonstrated to be a chalazion. Docetaxel induced Meibomian duct inflammation and blockage is the likely cause of this presentation in a patient with no history of eyelid masses in the past.
Gupta
S
S
Department of Medicine, School of Medicine and Biochemical Sciences, State University of New York at Buffalo, Buffalo, NY, USA.
Silliman
C G
CG
Trump
D L
DL
D000368:Aged; D000972:Antineoplastic Agents, Phytogenic / Q000009:adverse effects* / Q000627:therapeutic use; D002369:Castration; D017043:Chalazion / Q000139:chemically induced* / Q000175:diagnosis / Q000601:surgery; D000077143:Docetaxel; D005141:Eyelid Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000601:surgery; D006801:Humans; D008297:Male; D008537:Meibomian Glands / Q000187:drug effects* / Q000473:pathology; D011471:Prostatic Neoplasms / Q000188:drug therapy*; D043823:Taxoids / Q000009:adverse effects* / Q000627:therapeutic use
D000972:Antineoplastic Agents, Phytogenic; D043823:Taxoids; D000077143:Docetaxel