title: [The effect of amino acid nutritional support on serum tryptophan and melatonin in lung cancer patients receiving chemotherapy].
abstract: OBJECTIVE
  To investigate the effect of amino acid parenteral nutritional (PN) support on serum tryptophan and melatonin in non-small cell lung cancer (NSCLC) patients receiving chemotherapy.
  
  
  METHODS
  Seventy-two patients with inoperable NSCLC were divided into three groups randomly: control group, 250 ml/d amino acids PN therapy group and 500 ml/d amino acids PN therapy group. The same NP (cisplatin + vinorelbine) chemotherapy was carried out in all the three groups. During three sessions of chemotherapy,amino acids PN therapy was given to the amino acids PN therapy groups. Serum tryptophan and melatonin concentration changes were assessed before and after chemotherapy.
  
  
  RESULTS
  After chemotherapy the concentration of MT and Try were much lower than that before chemotherapy in the three group patients (P < 0.05). But the concentration of MT and Try in the PN group patients was higher than that in control group patients. The concentration of MT and Try in the 500 ml/d amino acid parenteral nutritional support group patients were significantly higher than that in the 250 ml/d group patients, the difference was significant (P < 0.05).
  
  
  CONCLUSIONS
  Amino acid parenteral nutritional support is beneficial to improve the lower concentration of serum MT and Try in NSCLC patients receiving chemotherapy, and a more significant effect can be achieved by the 500 ml/d amino acid parenteral nutritional support treatment.
authors.affiliation: Department of Geriatrics, Anhui Provincial Hospital, Hefei 230001, China.
authors.forename: Shi
authors.initials: S
authors.lastname: Yin
authors.forename: Shi-lian
authors.initials: SL
authors.lastname: Hu
authors.forename: Gan
authors.initials: G
authors.lastname: Shen
authors.forename: Wei-dong
authors.initials: WD
authors.lastname: Wang
authors.forename: Bing
authors.initials: B
authors.lastname: Hu
authors.forename: Wei-ping
authors.initials: WP
authors.lastname: Xu
authors.forename: Hua
authors.initials: H
authors.lastname: Wang
authors.forename: Qi
authors.initials: Q
authors.lastname: Zhang
mesh_terms: D000368:Aged; D000596:Amino Acids / Q000008:administration & dosage / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002289:Carcinoma, Non-Small-Cell Lung / Q000097:blood / Q000188:drug therapy / Q000628:therapy*; D002945:Cisplatin / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000628:therapy*; D008297:Male; D008550:Melatonin / Q000097:blood*; D009367:Neoplasm Staging; D010288:Parenteral Nutrition; D016896:Treatment Outcome; D014364:Tryptophan / Q000097:blood*; D014747:Vinblastine / Q000008:administration & dosage / Q000031:analogs & derivatives; D000077235:Vinorelbine
chemical_list: D000596:Amino Acids; D014747:Vinblastine; D014364:Tryptophan; D008550:Melatonin; D002945:Cisplatin; D000077235:Vinorelbine