[Effect of nebivolol on the blood oxygen transport].
The effect of nebivolol (30.0, 60.0, or 90.0 microM) on the blood oxygen transport was studied by incubation with blood samples for 120 min. Nebivolol increased the values of p50 (pO2 at 50% hemoglobin saturation with oxygen) under real pH and pCO2 (by 4.3 +/- 0.8 mm Hg at the lowest concentration (p < 0.01). The further (2- or 3- fold) growth in the concentration of nebivolol increased these values by 7.5 +/- 1.1 and 10.6 +/- 0.7 mm Hg, respectively (for both p < 0.01), thereby indicating the dose dependence of the drug effect. Greater drug concentration resulted in higher methemoglobin level and nitrate/nitrite content. The data can be explained by a change in the hemoglobin-oxygen affinity as a result of the influence of nebivolol through an autonomous intraerythrocyte system that regulates the blood oxygen-binding properties. In this case, NO acts as an important modifier of the hemoglobin function.
Zinchuk
V V
VV
Zinchuk
N V
NV
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000818:Animals; D001578:Benzopyrans / Q000494:pharmacology*; D004912:Erythrocytes / Q000187:drug effects; D004983:Ethanolamines / Q000494:pharmacology*; D006454:Hemoglobins / Q000187:drug effects* / Q000378:metabolism; D008706:Methemoglobin / Q000032:analysis; D000068577:Nebivolol; D009566:Nitrates / Q000097:blood; D009569:Nitric Oxide / Q000378:metabolism; D009573:Nitrites / Q000097:blood; D010100:Oxygen / Q000097:blood / Q000378:metabolism*; D010101:Oxygen Consumption / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D015657:Respiratory Transport / Q000187:drug effects*
D000319:Adrenergic beta-Antagonists; D001578:Benzopyrans; D004983:Ethanolamines; D006454:Hemoglobins; D009566:Nitrates; D009573:Nitrites; D000068577:Nebivolol; D009569:Nitric Oxide; D008706:Methemoglobin; D010100:Oxygen