title: Intra-aneurysmal hemodynamics during the growth of an unruptured aneurysm: in vitro study using longitudinal CT angiogram database.
abstract: OBJECTIVE
  The role of blood-flow biomechanics on the size, morphology, and growth of cerebral aneurysms is poorly known. The purpose of this study was to evaluate intra-aneurysmal hemodynamics before and after aneurysm growth.
  
  
  METHODS
  A flow-simulation study was performed in a middle cerebral artery (MCA) aneurysm with a bleb that grew after 1-year follow-up. Geometrically realistic in vitro models before and after aneurysm growth were constructed on the basis of CT angiograms. Blood-flow velocity, vorticity, and wall shear stress were obtained by using particle imaging velocimetry and laser Doppler velocimetry.
  
  
  RESULTS
  No significant quantitative differences were noted among the overall flow structures before and after aneurysm growth, with the exception of less vorticity in the bleb after aneurysm growth. A circulating flow pattern was seen within the aneurysm domes. A blood-flow separation was observed at the margins of the bleb. No impingement of inward flow into the enlarging bleb was noted. Before the aneurysm growth, the wall shear stress was high at the aneurysm neck and also at the margin of the bleb. The value of wall shear stress decreased in the deeper part of the bleb. This value decreased even more after the aneurysm growth.
  
  
  CONCLUSIONS
  Intra-aneurysmal hemodynamic structures before and after the growth of an MCA aneurysm were compared. Further investigation with a similar approach is mandatory to obtain a firm conclusion.
authors.affiliation: Division of Interventional Neuroradiology University of California, Los Angeles, Medical Center, CA 90095-1721, USA. stateshi@ucla.edu
authors.forename: S
authors.initials: S
authors.lastname: Tateshima
authors.forename: K
authors.initials: K
authors.lastname: Tanishita
authors.forename: H
authors.initials: H
authors.lastname: Omura
authors.forename: J P
authors.initials: JP
authors.lastname: Villablanca
authors.forename: F
authors.initials: F
authors.lastname: Vinuela
mesh_terms: D000328:Adult; D017542:Aneurysm, Ruptured / Q000000981:diagnostic imaging / Q000503:physiopathology; D001783:Blood Flow Velocity; D002533:Cerebral Angiography; D003198:Computer Simulation; D005260:Female; D006801:Humans; D002532:Intracranial Aneurysm / Q000000981:diagnostic imaging / Q000503:physiopathology*; D020768:Middle Cerebral Artery / Q000000981:diagnostic imaging / Q000503:physiopathology; D008955:Models, Cardiovascular; D033081:Shear Strength; D036542:Tomography, Spiral Computed; D014057:Tomography, X-Ray Computed