Bluetongue virus VP4 is an RNA-capping assembly line.
Eukaryotic organisms cap the 5' ends of their messenger RNAs by a series of four chemical reactions. Some viruses achieve this using a single molecule; the crystal structure of such an enzyme from bluetongue virus reveals an elongated modular architecture that provides a scaffold for an assemblage of active sites, two contributed by a domain of novel structure.
Sutton
Geoff
G
Division of Structural Biology, The Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Headington, Oxford, OX3 7BN, UK.
Grimes
Jonathan M
JM
Stuart
David I
DI
Roy
Polly
P
D017766:Acid Anhydride Hydrolases / Q000737:chemistry*; D001665:Binding Sites; D001820:Bluetongue virus / Q000737:chemistry*; D018360:Crystallography, X-Ray; D008780:Methyltransferases / Q000737:chemistry*; D011487:Protein Conformation; D012315:RNA Caps; D012316:RNA Nucleotidyltransferases / Q000737:chemistry*; D012367:RNA, Viral / Q000378:metabolism
D012315:RNA Caps; D012367:RNA, Viral; D008780:Methyltransferases; C055097:mRNA (guanine(N7))-methyltransferase; C055099:mRNA (nucleoside-O(2'))-methyltransferase; D012316:RNA Nucleotidyltransferases; D017766:Acid Anhydride Hydrolases; C023090:RNA triphosphatase