Additional support for an association between OLR1 and milk fat traits in cattle.
The bovine oxidized LDL receptor 1 (OLR1) was chosen as a candidate gene for association tests with milk composition traits. Genotyping of 773 Italian Brown Swiss for a SNP at position 8232 in OLR1 (NW_215807:g.8232C>A) revealed a frequency of 0.95 for the g.8232C allele. The University of Wisconsin Holstein resource population was genotyped for the OLR1 NW_215807:g.[7160C>T; 7161A>G; 8232C>A] SNPs, and four haplotypes were inferred based on the genotypes of sires and their daughters. Oxidized LDL receptor 1 haplotypes were significantly associated with fat percentage (P = 0.0015). Haplotype [C; A; C] was associated with a significant increase in fat percentage when compared with the other haplotypes.
Khatib
H
H
Department of Dairy Science, University of Wisconsin, Madison, WI 53706, USA. hkhatib@wisc.edu
Rosa
G J M
GJ
Weigel
K
K
Schiavini
F
F
Santus
E
E
Bagnato
A
A
D000818:Animals; D002417:Cattle / Q000235:genetics*; D003612:Dairying; D005838:Genotype; D006239:Haplotypes / Q000235:genetics; D007558:Italy; D008055:Lipids / Q000032:analysis*; D008892:Milk / Q000737:chemistry*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D051127:Scavenger Receptors, Class E / Q000235:genetics*
D008055:Lipids; D051127:Scavenger Receptors, Class E