title: Superior vena cava syndrome with central venous catheter for chemotherapy treated successfully with fibrinolysis.
abstract: Recently, there has been an increase in the number of cases of superior vena cava (SVC) syndrome associated with chronic indwelling central venous catheters. Fibrinolytic therapy and endovascular treatment are currently achieving good results. We present a case history of a patient with SVC with a catheter used for chemotherapy, which was successfully treated with catheter-directed (intraclot) infusion thrombolytic therapy with urokinase.
authors.affiliation: Department of Vascular Surgery, Hospital Central de la Defensa, Gómez Ulla, Madrid, Spain. jfge41@wanadoo.es
authors.forename: J F
authors.initials: JF
authors.lastname: Guijarro Escribano
authors.forename: R F
authors.initials: RF
authors.lastname: Antón
authors.forename: A
authors.initials: A
authors.lastname: Colmenarejo Rubio
authors.forename: L
authors.initials: L
authors.lastname: Sáenz Cascos
authors.forename: F
authors.initials: F
authors.lastname: Sainz González
authors.forename: R
authors.initials: R
authors.lastname: Alguacil Rodríguez
mesh_terms: D000925:Anticoagulants / Q000008:administration & dosage / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery; D002405:Catheterization, Central Venous / Q000009:adverse effects*; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D003374:Coumarins / Q000008:administration & dosage / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D005343:Fibrinolytic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007262:Infusions, Intravenous; D015412:Mastectomy, Segmental; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged; D018714:Radiotherapy, Adjuvant; D013350:Subclavian Vein; D013479:Superior Vena Cava Syndrome / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D015912:Thrombolytic Therapy / Q000379:methods*; D014568:Urokinase-Type Plasminogen Activator / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D000925:Anticoagulants; D000970:Antineoplastic Agents; D003374:Coumarins; D005343:Fibrinolytic Agents; C493312:dicumarin; D014568:Urokinase-Type Plasminogen Activator; D008775:Methylprednisolone