title: Paraoxonase 2 gene C311S polymorphism is associated with a risk of large vessel disease stroke in a Polish population.
abstract: BACKGROUND
  Oxidative stress plays a role in atherosclerosis. Human paraoxonase (PON) gene products exhibit antioxidant properties. We studied the significance of the Q192R and M55L polymorphisms of the PON1 gene and the C311S polymorphism of the PON2 gene in different etiologies of ischemic stroke.
  
  
  METHODS
  One hundred and thirty-six patients with large vessel disease (LVD) stroke, 140 with small vessel disease stroke, 272 with cardioembolic stroke, and their age- and sex-matched controls were included. PON genotypes were evaluated by PCR-RFLP analyses.
  
  
  RESULTS
  The distribution of PON1 polymorphisms was similar in each stroke group and in the respective controls. Genotypes with the C allele of the PON2 gene C311S polymorphism were overrepresented in LVD stroke patients as compared with their controls, both in univariate and multivariate (dominant model: OR = 1.58, 95% CI: 1.006-2.48) analyses.
  
  
  CONCLUSIONS
  The genotype with the C allele of the PON2 gene is a risk factor for LVD stroke in a Polish population.
authors.affiliation: Department of Neurology, Jagiellonian University, Krakow, Poland. slowik@neuro.cm-uj.krakow.pl
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Slowik
authors.forename: Dorota
authors.initials: D
authors.lastname: Wloch
authors.forename: Pawel
authors.initials: P
authors.lastname: Szermer
authors.forename: Pawel
authors.initials: P
authors.lastname: Wolkow
authors.forename: Maciej
authors.initials: M
authors.lastname: Malecki
authors.forename: Joanna
authors.initials: J
authors.lastname: Pera
authors.forename: Wojciech
authors.initials: W
authors.lastname: Turaj
authors.forename: Tomasz
authors.initials: T
authors.lastname: Dziedzic
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Klimkowicz-Mrowiec
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Kopec
authors.forename: Denise A
authors.initials: DA
authors.lastname: Figlewicz
authors.forename: Andrzej
authors.initials: A
authors.lastname: Szczudlik
mesh_terms: D043303:Aryldialkylphosphatase / Q000235:genetics*; D050197:Atherosclerosis / Q000150:complications / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D002545:Brain Ischemia / Q000150:complications / Q000235:genetics* / Q000473:pathology; D016022:Case-Control Studies; D002533:Cerebral Angiography / Q000379:methods; D005820:Genetic Testing; D005838:Genotype; D006801:Humans; D008279:Magnetic Resonance Imaging; D016017:Odds Ratio; D010641:Phenotype; D011044:Poland; D020641:Polymorphism, Single Nucleotide; D011446:Prospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D020521:Stroke / Q000235:genetics* / Q000473:pathology; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography
chemical_list: D043303:Aryldialkylphosphatase; C468406:PON1 protein, human; C468411:PON2 protein, human