HIV and parasitic infection and the effect of treatment among adult outpatients in Malawi.
We measured enteric parasitic infection prevalence and the effect of treatment on human immunodeficiency virus (HIV) RNA levels to assess their importance to HIV primary care in resource-limited settings. Adults in Lilongwe, Malawi, were evaluated, treated, and followed-up for parasitic and HIV infections. Of 389 patients, 266 (68%) were HIV infected. Helminth infections were more common in HIV-uninfected than in HIV-infected patients (39% vs. 17%). Among HIV-infected patients, helminth infections were associated with higher CD4 cell counts but not with higher HIV RNA levels. Successful treatment of parasitic infections had no effect on HIV RNA levels. Although common, parasitic infections did not impact HIV RNA levels.
Hosseinipour
Mina C
MC
University of North Carolina Project, Lilongwe, Malawi. Mina_Hosseinipour@med.unc.edu
Napravnik
Sonia
S
Joaki
George
G
Gama
Syze
S
Mbeye
Nyanyiwe
N
Banda
Blessings
B
Martinson
Francis
F
Hoffman
Irving
I
Cohen
Myron S
MS
D000328:Adult; D015766:Albendazole / Q000008:administration & dosage / Q000627:therapeutic use; D000553:Ambulatory Care; D000871:Anthelmintics / Q000008:administration & dosage / Q000627:therapeutic use; D000981:Antiprotozoal Agents / Q000008:administration & dosage / Q000627:therapeutic use; D018791:CD4 Lymphocyte Count; D005243:Feces / Q000469:parasitology; D005260:Female; D015658:HIV Infections / Q000097:blood / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology* / Q000821:virology*; D015497:HIV-1 / Q000235:genetics / Q000302:isolation & purification*; D006373:Helminthiasis / Q000097:blood / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology* / Q000469:parasitology / Q000652:urine; D006801:Humans; D007411:Intestinal Diseases, Parasitic / Q000097:blood / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology* / Q000469:parasitology / Q000652:urine; D008295:Malawi / Q000453:epidemiology; D008297:Male; D008507:Medically Underserved Area; D008795:Metronidazole / Q000008:administration & dosage / Q000627:therapeutic use; D011223:Praziquantel / Q000008:administration & dosage / Q000627:therapeutic use; D012367:RNA, Viral / Q000032:analysis; D019562:Viral Load; D017201:Virus Shedding
D000871:Anthelmintics; D000981:Antiprotozoal Agents; D012367:RNA, Viral; D008795:Metronidazole; D011223:Praziquantel; D015766:Albendazole