Rational peptide selection to detect human immunodeficiency virus type 1-specific T-cell responses under resource-limited conditions.
Understanding human immunodeficiency virus type 1 (HIV-1)-specific cytotoxic T-lymphocyte responses is important for the development of vaccines and therapies. We describe a novel method for the rational selection of peptides that target stable regions of the HIV-1 genome, rich in epitopes specifically recognized by the study population. This method will be of particular use under resource/sample-limited conditions.
Willberg
C B
CB
Division of Experimental Medicine, Department of Medicine, UCSF, San Francisco, CA 94158, USA.
Pillai
S K
SK
Sharp
E R
ER
Rosenberg
M G
MG
Agudelo
J D
JD
Barbour
J D
JD
Nixon
D F
DF
D000595:Amino Acid Sequence; D000939:Epitopes / Q000235:genetics / Q000276:immunology; D016679:Genome, Viral; D015497:HIV-1 / Q000235:genetics / Q000276:immunology*; D006801:Humans; D008969:Molecular Sequence Data; D010455:Peptides / Q000737:chemistry / Q000191:economics* / Q000276:immunology*; D012641:Selection, Genetic; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*
D000939:Epitopes; D010455:Peptides