title: [Clinical research about brain oxygen metabolism and neuroelectrophysiology during mild hypothermia in patients with severe head injury].
abstract: OBJECTIVE
  To observe the changes of brain oxygen metabolism and neuroelectrophysiology after severe brain injury, and the effects of hypothermia on severe brain injury.
  
  
  METHODS
  148 patients with severe brain injury (GCS 3 - 8, admitted within 10 hours from injury) were selected for this study. Patients were divided into 3 groups, Group GCS 7 - 8, Group GCS 5 - 6 and Group GCS 3 - 4. Every group were also randomly assigned to normothermia and hypothermia subgroup. Patients in the hypothermia group were cooled to 32 approximately 34 degrees C. SLSEP, BAEP, P(br)O(2) and rSaO(2) were recorded in each group at the same time.
  
  
  RESULTS
  In the Group GCS 7 - 8, N20 in SLSEP, I/V in BAEP and rSaO(2) were improved significantly after mild hypothermia treatment, and P(br)O(2) was decreased by hypothermia; In the Group GCS 5 - 6, N20 in SLSEP, I/V in BAEP and rSaO(2) were improved by hypothermia, and P(br)O(2) was decreased in hypothermia subgroup; In the Group GCS 3 - 4, no significant difference was found.
  
  
  CONCLUSIONS
  Mild hypothermia has a significant effect on patients of GCS 7 - 8 and a doubt effect on patients of GCS 5 - 6. It seem no effect on patients of GCS 3 - 4. Brain oxygen metabolism and neuroelectrophysiology are important to value the therapeutic effect on severe brain injury.
authors.affiliation: Department of Neurosurgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China. yanyi2005@gmail.com
authors.forename: Yi
authors.initials: Y
authors.lastname: Yan
authors.forename: Wen-yuan
authors.initials: WY
authors.lastname: Tang
authors.forename: Jian-guo
authors.initials: JG
authors.lastname: He
authors.forename: Jin-jian
authors.initials: JJ
authors.lastname: Gao
authors.forename: Wei
authors.initials: W
authors.lastname: Dan
authors.forename: Dong
authors.initials: D
authors.lastname: Zhong
authors.forename: Gang
authors.initials: G
authors.lastname: Yang
authors.forename: Ke
authors.initials: K
authors.lastname: Liu
authors.forename: Han-lin
authors.initials: HL
authors.lastname: Huang
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000378:metabolism* / Q000503:physiopathology*; D006259:Craniocerebral Trauma / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy*; D016057:Evoked Potentials, Auditory, Brain Stem; D005073:Evoked Potentials, Somatosensory; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007036:Hypothermia, Induced; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000378:metabolism*; D016896:Treatment Outcome
chemical_list: D010100:Oxygen