title: Synthesis of biaryls via decarboxylative Pd-catalyzed cross-coupling reaction.
abstract: [reaction: see text] A simple and efficient route to biaryls via Pd-catalyzed decarboxylative cross-couplings of arene carboxylic acids and aryl iodides is reported. The PdCl2/AsPh3 catalytic system in the presence of Ag2CO3 in DMSO was found to be particularly efficient to perform this transformation. This reaction can be extended to the synthesis of various biaryls, including sterically hindered biaryls, with yields ranging from 58% to 90%.
authors.affiliation: Université de Haute-Alsace, Ecole Nationale Supérieure de Chimie de Mulhouse, Laboratoire de Chimie Organique et Bioorganique, UMR-CNRS 7015, 3 rue Alfred Werner, 68093 Mulhouse Cedex, France. jean-michel.becht@uha.fr
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Becht
authors.forename: Cédric
authors.initials: C
authors.lastname: Catala
authors.forename: Claude Le
authors.initials: CL
authors.lastname: Drian
authors.forename: Alain
authors.initials: A
authors.lastname: Wagner