title: [Vitamin D receptor gene polymorphism is not associated with bone mineral density of pre-menopausal women in Guangzhou].
abstract: OBJECTIVE
  To investigate the prevalence of vitamin D receptor (VDR) gene polymorphism in pre-menopausal women in Guangzhou and study its relationship with bone mineral density(BMD).
  
  
  METHODS
  The genotypes of VDR gene in 193 per-menopausal women in Guangzhou were analyzed by polymerase chain reaction-restriction fragment length polymorphism. BMD of the lumbar spine, femoral neck, greater trochanter and Ward's triangle were measured by dual-energy X-ray absorptiometry.
  
  
  RESULTS
  In the 193 subjects, 120 (66.2%) were identified as VDR bb genotype, 64 (33.2%) as Bb, and 9 (4.6%) as BB. The b allele frequencies reached 78.76%, and B allele frequencies was 21.24%. The distribution followed the Hardy-Weinberg equilibrium. No significant difference was found in BMD among the subjects with different genotypes.
  
  
  CONCLUSIONS
  VDR genotype is not related to BMD, and VDR polymorphism can not be used as a genetic marker for predicting the risk of osteoporosis in pre-menopausal women in Guangzhou.
authors.affiliation: Center of Osteoporosis, People's Hospital of Guangdong Province, Guangzhou 510080, China. wuwen1964@ 163.com
authors.forename: Wen
authors.initials: W
authors.lastname: Wu
authors.forename: Xi-mei
authors.initials: XM
authors.lastname: Zhi
authors.forename: Dong-feng
authors.initials: DF
authors.lastname: Li
authors.forename: Kai
authors.initials: K
authors.lastname: Lin
authors.forename: Ling
authors.initials: L
authors.lastname: Xu
authors.forename: Yan-hong
authors.initials: YH
authors.lastname: Yang
mesh_terms: D015502:Absorptiometry, Photon; D000328:Adult; D000704:Analysis of Variance; D015519:Bone Density; D002681:China; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D010024:Osteoporosis / Q000235:genetics / Q000378:metabolism; D011110:Polymorphism, Genetic; D017697:Premenopause; D018167:Receptors, Calcitriol / Q000235:genetics*
chemical_list: D018167:Receptors, Calcitriol