Do immunisations reduce the risk for SIDS? A meta-analysis.
BACKGROUND
There are claims that immunisations cause sudden infant death syndrome (SIDS), but some studies have found either no association or that they are associated with a reduced risk of SIDS.


OBJECTIVE
To conduct a meta-analysis examining the relationship between immunisation and SIDS.


METHODS
Nine case-controls studies were identified examining this association, of which four adjusted for potential confounders.


RESULTS
The summary odds ratio (OR) in the univariate analysis suggested that immunisations were protective, but the presence of heterogeneity makes it difficult to combine these studies. The summary OR for the studies reporting multivariate ORs was 0.54 (95% CI=0.39-0.76) with no evidence of heterogeneity.


CONCLUSIONS
Immunisations are associated with a halving of the risk of SIDS. There are biological reasons why this association may be causal, but other factors, such as the healthy vaccinee effect, may be important. Immunisations should be part of the SIDS prevention campaigns.
Vennemann
M M T
MM
Institute of Legal Medicine, University of Münster, Roentgenstrasse 23, 48129 Münster, Germany. Mechtild.Vennemann@ukmuenster.de
Höffgen
M
M
Bajanowski
T
T
Hense
H-W
HW
Mitchell
E A
EA
D000704:Analysis of Variance; D016022:Case-Control Studies; D006801:Humans; D007114:Immunization; D007223:Infant; D007231:Infant, Newborn; D016017:Odds Ratio; D012306:Risk; D013398:Sudden Infant Death / Q000517:prevention & control*