title: Mitochondrial dysfunction: impact on exercise performance and cellular aging.
abstract: Innovative noninvasive methods open a new window on the cell in vivo. This window reveals that the tempo of mitochondrial dysfunction with age varies among muscles and in proportion to Type II muscle fiber content. Exercise training can reverse age-related dysfunction, thereby providing an intervention to slow the pace of aging and disability in the elderly.
authors.affiliation: Department of Radiology, University of Washington Medical Center, Seattle, WA 98195-7115, USA. kconley@u.washington.edu
authors.forename: Kevin E
authors.initials: KE
authors.lastname: Conley
authors.forename: Sharon A
authors.initials: SA
authors.lastname: Jubrias
authors.forename: Catherine E
authors.initials: CE
authors.lastname: Amara
authors.forename: David J
authors.initials: DJ
authors.lastname: Marcinek
mesh_terms: D000328:Adult; D016922:Cellular Senescence / Q000502:physiology*; D004272:DNA, Mitochondrial; D015444:Exercise / Q000502:physiology*; D006801:Humans; D008931:Mitochondria, Muscle / Q000473:pathology / Q000502:physiology*; D018482:Muscle, Skeletal / Q000473:pathology / Q000502:physiology*; D013178:Sports Medicine
chemical_list: D004272:DNA, Mitochondrial