Role of hepatic opioid receptors in the regulation of bile excretion.
Experiments on isolated rat liver perfused with Ringer-Krebs bicarbonate buffer showed that stimulation of delta-opiate receptors in this organ increases bile flow rate and taurocholate secretion. Stimulation of micro-opiate receptors decelerated bile production and inhibited taurocholate secretion. Acceleration of bile production and stimulation of taurocholate secretion under the influence of dalargin is probably related to its interaction with delta-opiate receptors in the liver.
Medvedev
M A
MA
Siberian State Medical University, Tomsk. medvedev@ssmu.net.ru
Rudin
I V
IV
Garaeva
A F
AF
D000818:Animals; D001646:Bile / Q000378:metabolism*; D020875:Enkephalin, Ala(2)-MePhe(4)-Gly(5)- / Q000494:pharmacology; D016308:Enkephalin, Leucine-2-Alanine / Q000031:analogs & derivatives / Q000494:pharmacology; D066298:In Vitro Techniques; D008099:Liver / Q000502:physiology*; D009270:Naloxone / Q000494:pharmacology; D051381:Rats; D017465:Receptors, Opioid, delta / Q000187:drug effects / Q000502:physiology*; D017450:Receptors, Opioid, mu / Q000502:physiology*; D013656:Taurocholic Acid / Q000378:metabolism
D017465:Receptors, Opioid, delta; D017450:Receptors, Opioid, mu; D020875:Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; D009270:Naloxone; D013656:Taurocholic Acid; D016308:Enkephalin, Leucine-2-Alanine; C040996:enkephalin-Leu, Ala(2)-Arg(6)-