The application of an enamel matrix protein derivative (Emdogain) in regenerative periodontal therapy: a review.
Regenerative periodontal therapy aims at reconstitution of the lost periodontal structures such as new formation of root cementum, periodontal ligament and alveolar bone. Findings from basic research indicate that enamel matrix protein derivative (EMD) has a key role in periodontal wound healing. Histological results from animal and human studies have shown that treatment with EMD promotes periodontal regeneration. Moreover, clinical studies have indicated that treatment with EMD positively influences periodontal wound healing in humans. This review aims to present an overview of evidence-based clinical indications for regenerative therapy with EMD.
Sculean
Anton
A
Department of Periodontology, Radboud University Medical Center, Nijmegen, The Netherlands. a.sculean@dent.umcn.nl
Schwarz
Frank
F
Becker
Jurgen
J
Brecx
Michel
M
D016301:Alveolar Bone Loss / Q000188:drug therapy* / Q000601:surgery; D000818:Animals; D001861:Bone Regeneration / Q000187:drug effects*; D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy; D003746:Dental Enamel Proteins / Q000494:pharmacology*; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods*; D006801:Humans; D017622:Periodontal Attachment Loss / Q000188:drug therapy* / Q000601:surgery; D013524:Surgical Flaps; D014092:Tooth Root / Q000187:drug effects* / Q000601:surgery; D014945:Wound Healing / Q000187:drug effects
D003746:Dental Enamel Proteins; C109069:enamel matrix proteins