Hybrid gadolinium oxide nanoparticles: multimodal contrast agents for in vivo imaging.
Luminescent hybrid nanoparticles with a paramagnetic Gd2O3 core were applied as contrast agents for both in vivo fluorescence and magnetic resonance imaging. These hybrid particles were obtained by encapsulating Gd2O3 cores within a polysiloxane shell which carries organic fluorophores and carboxylated PEG covalently tethered to the inorganic network. Longitudinal proton relaxivities of these particles are higher than the positive contrast agents like Gd-DOTA which are commonly used for clinical magnetic resonance imaging. Moreover these particles can be followed up by fluorescence imaging. This study revealed that these particles suited for dual modality imaging freely circulate in the blood vessels without undesirable accumulation in lungs and liver.
Bridot
Jean-Luc
JL
Laboratoire de Physico-Chimie des Matériaux Luminescents, UMR 5620 CNRS-Université Claude Bernard Lyon 1, 69622 Villeurbanne Cedex, France.
Faure
Anne-Charlotte
AC
Laurent
Sophie
S
Rivière
Charlotte
C
Billotey
Claire
C
Hiba
Bassem
B
Janier
Marc
M
Josserand
Véronique
V
Coll
Jean-Luc
JL
Elst
Luce Vander
LV
Muller
Robert
R
Roux
Stéphane
S
Perriat
Pascal
P
Tillement
Olivier
O
D000818:Animals; D003287:Contrast Media / Q000737:chemistry / Q000493:pharmacokinetics*; D005453:Fluorescence; D005682:Gadolinium / Q000097:blood / Q000737:chemistry / Q000493:pharmacokinetics*; D006571:Heterocyclic Compounds / Q000737:chemistry; D008099:Liver / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D051379:Mice; D008819:Mice, Nude; D053758:Nanoparticles / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry; D051381:Rats; D012833:Siloxanes / Q000737:chemistry
D003287:Contrast Media; D006571:Heterocyclic Compounds; D009942:Organometallic Compounds; D012833:Siloxanes; D011092:Polyethylene Glycols; C030581:gadolinium oxide; C050823:gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate; D005682:Gadolinium