Enantio- and regioselective heck-type reaction of arylboronic acids with 2,3-dihydrofuran.
Reported herein is a protocol for the enantioselective Pd(II)-catalyzed Heck-type reaction between arylboronic acids and 2,3-dihydrofuran. The highest chemical and optical yields were obtained when a Pd(OAc)2/(R)-MeO(biphenylphosphine) or a Pd(OAc)2/(R)-(2,2'-bis(diphenylphosphino)-1,1'-binaphthyl) catalyst and a Cu(OAc)2 reoxidant were employed.
Penn
Liza
L
Department of Organic Chemistry, The Hebrew University of Jerusalem, Jerusalem, 91904 Israel.
Shpruhman
Alina
A
Gelman
Dmitri
D