A preliminary fMRI study of the effects on cortical activation of the treatment of refractory auditory hallucinations with rTMS.
Three patients underwent fMRI during a word generation task before and after successful treatment of auditory hallucinations with rTMS and were compared to four control subjects. There was a significant increase and more normal task related brain activation in brain areas involved in language processing including left temporoparietal cortex after rTMS treatment.
Fitzgerald
Paul B
PB
Alfred Psychiatry Research Centre, The Alfred and Monash University Department of Psychological Medicine, Commercial Rd, Melbourne, Victoria 3004, Australia. paul.fitzgerald@med.monash.edu.au
Sritharan
Anusha
A
Benitez
Jessica
J
Daskalakis
Z Jeff
ZJ
Jackson
Graeme
G
Kulkarni
Jayashri
J
Egan
Gary F
GF
D000328:Adult; D000077582:Amisulpride; D014150:Antipsychotic Agents / Q000627:therapeutic use; D003024:Clozapine / Q000627:therapeutic use; D003131:Combined Modality Therapy; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006212:Hallucinations / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010296:Parietal Lobe / Q000378:metabolism* / Q000503:physiopathology*; D011930:Reaction Time; D012559:Schizophrenia / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy; D013469:Sulpiride / Q000031:analogs & derivatives / Q000627:therapeutic use; D013702:Temporal Lobe / Q000378:metabolism* / Q000503:physiopathology*; D050781:Transcranial Magnetic Stimulation / Q000379:methods*; D016896:Treatment Outcome
D014150:Antipsychotic Agents; D013469:Sulpiride; D000077582:Amisulpride; D003024:Clozapine