title: Suppression of postprandial hypertriglyceridemia in rats and mice by oolong tea polymerized polyphenols.
abstract: Oolong tea-polymerized polyphenols (OTPP) are characterized polyphenols produced from semi-fermented tea (oolong tea). In the present study, we evaluated the suppressive effects of oolong tea extract and OTPP on postprandial hypertriglyceridemia in rats and mice. Lymphatic recovery of triglycerides in rats cannulated in the thoracic duct was delayed by the administration of oolong tea extract at 100 and 200 mg per head, and more effectively than with green tea extract. OTPP delayed lymphatic triglyceride absorption at 20 mg/head, though (-)-epigallocatechin gallate (EGCG) did not do so at the same dose. OTPP also suppressed postprandial hypertriglyceridemia after administration of olive oil in mice. The area under the curve (AUC) of plasma triglycerides was significantly decreased, by 53% and 76%, in the 500 and 1,000 mg/kg OTPP groups respectively, as compared with the control group. These results suggest that OTPP is responsible for the suppression of hypertriglyceridemia by ingestion of oolong tea.
authors.affiliation: Suntory Institute for Health Care Science, Osaka, Japan. yoshiko_toyoda@suntory.co.jp
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Toyoda-Ono
authors.forename: Makiko
authors.initials: M
authors.lastname: Yoshimura
authors.forename: Masaaki
authors.initials: M
authors.lastname: Nakai
authors.forename: Yuko
authors.initials: Y
authors.lastname: Fukui
authors.forename: Sumio
authors.initials: S
authors.lastname: Asami
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Shibata
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Kiso
authors.forename: Ikuo
authors.initials: I
authors.lastname: Ikeda
mesh_terms: D000818:Animals; D002392:Catechin / Q000031:analogs & derivatives / Q000494:pharmacology; D005419:Flavonoids / Q000494:pharmacology*; D015228:Hypertriglyceridemia / Q000188:drug therapy*; D008208:Lymphatic System / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010636:Phenols / Q000494:pharmacology*; D059808:Polyphenols; D019518:Postprandial Period / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013662:Tea / Q000737:chemistry*; D014280:Triglycerides / Q000378:metabolism
chemical_list: D005419:Flavonoids; D010636:Phenols; D059808:Polyphenols; D013662:Tea; D014280:Triglycerides; D002392:Catechin; C045651:epigallocatechin gallate