[Mitochondrial ATP-dependent potassium channel. 2. The role of the channel in protection of the heart against ischemia].
The cardioprotective properties of pharmacological and metabolic activators of mitoKATP are reviewed. Metabolic activators of the channels and data on their cardioprotective properties are discussed in the review. The authors adduce their own data concerning cardioprotective properties of mitoKATP channel metabolic activator (UDP). In experimental animals, UDP precursors, uridine and UMP, decrease myocardial ischemic alteration index and T-wave amplitude within 60 min after occlusion of the left coronary artery. Both effects are prevented by mitoKATP channel inhibitors, glibenclamide and 5-HD. UMP and uridine possess antiarrhythmic properties as well. These preparations decrease the number of premature ventricular beats, the duration of ventricular tachycardia and fibrillation, and these effects are eliminated mainly by glibenclamide. Thus, mitoKATP plays a significant role in prevention of both ischemic lesions and rhythm disorders. The prospects of application of metabolic activators to prevent and treat myocardial infarction are discussed.
Mironova
G D
GD
Kachaeeva
E V
EV
Krylova
I B
IB
Rodionova
O M
OM
Balina
M I
MI
Evdokimova
N R
NR
Sapronov
N S
NS
D000222:Adaptation, Physiological / Q000502:physiology; D006801:Humans; D025261:Mitochondrial Proton-Translocating ATPases / Q000502:physiology*; D017202:Myocardial Ischemia / Q000503:physiopathology*; D015221:Potassium Channels / Q000502:physiology*
D015221:Potassium Channels; D025261:Mitochondrial Proton-Translocating ATPases