title: Synaptic and mitochondrial morphometry provides structural correlates of successful brain aging.
abstract: Average synaptic size (S), synaptic numeric density (Nv) and surface density (Sv), average mitochondrial volume, mitochondrial numeric density, and mitochondrial volume density were measured by morphometry in the frontal (FC) and temporal (TC) cortex from adult and old monkeys (Macaca fascicularis). In relation to aging, Sv did not change, while Nv was significantly decreased in TC, but not in FC. S was significantly increased in FC and TC. No significant difference due to age was found with regard to mitochondrial ultrastructure. Considering the functional significance of the above parameters, their substantial age-related constancy suggests that they may reasonably represent structural correlates of successful brain aging.
authors.affiliation: Neurobiology of Aging Laboratory, INRCA Research Department, Via Birarelli 8, 60121 Ancona, Italy. c.bertoni@inrca.it
authors.forename: Carlo
authors.initials: C
authors.lastname: Bertoni-Freddari
authors.forename: Patrizia
authors.initials: P
authors.lastname: Fattoretti
authors.forename: Belinda
authors.initials: B
authors.lastname: Giorgetti
authors.forename: Yessica
authors.initials: Y
authors.lastname: Grossi
authors.forename: Marta
authors.initials: M
authors.lastname: Balietti
authors.forename: Tiziana
authors.initials: T
authors.lastname: Casoli
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Di Stefano
authors.forename: Gemma
authors.initials: G
authors.lastname: Perretta
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D001921:Brain / Q000254:growth & development* / Q000648:ultrastructure*; D002540:Cerebral Cortex / Q000254:growth & development / Q000648:ultrastructure; D008252:Macaca fascicularis; D008928:Mitochondria / Q000648:ultrastructure*; D013569:Synapses / Q000648:ultrastructure*