title: Treatment of chronic pulmonary aspergillosis by voriconazole in nonimmunocompromised patients.
abstract: BACKGROUND
  There is no recognized medical treatment for chronic pulmonary aspergillosis (CPA) apart from surgery in patients with simple aspergilloma. To evaluate the efficacy of voriconazole in this setting, we conducted a retrospective multicenter study over a 3-year period.
  
  
  METHODS
  For inclusion in the study, patients had to have received voriconazole for treatment of confirmed or probable CPA with a follow-up of at least 6 months. Clinical, radiologic, and mycologic data were collected at baseline, every 2 to 3 months, and at the end of treatment or at the date point.
  
  
  RESULTS
  Twenty-four patients were included in the study, among which 9 patients presented with chronic cavitary pulmonary aspergillosis and 15 presented with chronic necrotizing pulmonary aspergillosis (CNPA). Voriconazole was given as a first-line treatment to 13 patients. The median duration of treatment and follow-up were 6.5 and 10 months, respectively. Three patients had to stop treatment with voriconazole because of toxicity. Symptoms and imagery findings were improved in 16 of 24 patients and 17 of 24 patients, respectively, at the end of follow-up. Mycology, which was positive at baseline in 21 of 23 patients, was negative in 18 of 19 patients at the end of follow-up; serologic test results were also negative in 6 of 19 evaluable patients, all of whom had CNPA. Improved radioclinical findings and mycologic eradication were observed at the end of follow-up in 11 of 19 patients (58%). Patients in whom the disease was controlled had a significantly longer median duration of treatment than patients in whom it was uncontrolled (9 vs 6 months, respectively; p = 0.04).
  
  
  CONCLUSIONS
  Voriconazole provides effective treatment of CPA with an acceptable level of toxicity.
authors.affiliation: Department of Pneumology and Respiratory Intensive Care, Assistance Publique-Hôpitaux de Paris, Tenon Hospital, 4 rue de la Chine, 75970 Paris, France.
authors.forename: Juliette
authors.initials: J
authors.lastname: Camuset
authors.forename: Hilario
authors.initials: H
authors.lastname: Nunes
authors.forename: Marie-Christine
authors.initials: MC
authors.lastname: Dombret
authors.forename: Anne
authors.initials: A
authors.lastname: Bergeron
authors.forename: Priscilla
authors.initials: P
authors.lastname: Henno
authors.forename: Bruno
authors.initials: B
authors.lastname: Philippe
authors.forename: Gaelle
authors.initials: G
authors.lastname: Dauriat
authors.forename: Gilles
authors.initials: G
authors.lastname: Mangiapan
authors.forename: Antoine
authors.initials: A
authors.lastname: Rabbat
authors.forename: Jacques
authors.initials: J
authors.lastname: Cadranel
mesh_terms: D000328:Adult; D000368:Aged; D000935:Antifungal Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001229:Aspergillosis, Allergic Bronchopulmonary / Q000188:drug therapy* / Q000276:immunology; D002908:Chronic Disease; D015331:Cohort Studies; D004305:Dose-Response Relationship, Drug; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007121:Immunocompetence; D008168:Lung / Q000276:immunology / Q000382:microbiology; D008297:Male; D008875:Middle Aged; D011743:Pyrimidines / Q000009:adverse effects / Q000627:therapeutic use*; D012189:Retrospective Studies; D014230:Triazoles / Q000009:adverse effects / Q000627:therapeutic use*; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole