title: [Psychotic syndrome developing into dementia as a clinical manifestation of mitochondrial DNA deletion].
abstract: The manifestations of mitochondrial disease are variable, affecting more frequently the organs with high aerobic metabolism in which they are more abundant, for example the nervous system. The beginning of symptoms in general is observed at childhood, but some patients presented on adult age. We present an atypical case associated with mitochondrial DNA deletion. A 39-years-old man with psychiatric symptoms that configured initial clinical picture and only after 12 years of the beginning of symptoms neurological alterations became noticeable. The diagnosis of mitochondrial illness was confirmed by muscle biopsy being documented mitochondrial DNA deletion.
authors.affiliation: Instituto de Neurologia Deolindo Couto, Universidade Federal do Rio de Janeiro, Rua conde de Bonfim 211/702, CEP 20520-050 Rio de Janeiro, RJ, Brazil. luizneurol@terra.com.br
authors.forename: Luiz Felipe Rocha
authors.initials: LF
authors.lastname: Vasconcellos
authors.forename: Ana Claudia Celestino
authors.initials: AC
authors.lastname: Leite
authors.forename: José Luis Sá
authors.initials: JL
authors.lastname: Cavalcanti
authors.forename: Denise Madeira
authors.initials: DM
authors.lastname: Moreira
authors.forename: Denise
authors.initials: D
authors.lastname: Feijó
authors.forename: Carolina Fischinger Moura de
authors.initials: CF
authors.lastname: Souza
mesh_terms: D000328:Adult; D004272:DNA, Mitochondrial / Q000235:genetics*; D003704:Dementia / Q000175:diagnosis / Q000235:genetics*; D017353:Gene Deletion; D006801:Humans; D008297:Male; D028361:Mitochondrial Diseases / Q000150:complications* / Q000175:diagnosis / Q000235:genetics; D011618:Psychotic Disorders / Q000175:diagnosis / Q000235:genetics*; D013577:Syndrome
chemical_list: D004272:DNA, Mitochondrial