[Vitamin D receptor gene polymorphism is not associated with bone mineral density of pre-menopausal women in Guangzhou].
OBJECTIVE
To investigate the prevalence of vitamin D receptor (VDR) gene polymorphism in pre-menopausal women in Guangzhou and study its relationship with bone mineral density(BMD).


METHODS
The genotypes of VDR gene in 193 per-menopausal women in Guangzhou were analyzed by polymerase chain reaction-restriction fragment length polymorphism. BMD of the lumbar spine, femoral neck, greater trochanter and Ward's triangle were measured by dual-energy X-ray absorptiometry.


RESULTS
In the 193 subjects, 120 (66.2%) were identified as VDR bb genotype, 64 (33.2%) as Bb, and 9 (4.6%) as BB. The b allele frequencies reached 78.76%, and B allele frequencies was 21.24%. The distribution followed the Hardy-Weinberg equilibrium. No significant difference was found in BMD among the subjects with different genotypes.


CONCLUSIONS
VDR genotype is not related to BMD, and VDR polymorphism can not be used as a genetic marker for predicting the risk of osteoporosis in pre-menopausal women in Guangzhou.
Wu
Wen
W
Center of Osteoporosis, People's Hospital of Guangdong Province, Guangzhou 510080, China. wuwen1964@ 163.com
Zhi
Xi-mei
XM
Li
Dong-feng
DF
Lin
Kai
K
Xu
Ling
L
Yang
Yan-hong
YH
D015502:Absorptiometry, Photon; D000328:Adult; D000704:Analysis of Variance; D015519:Bone Density; D002681:China; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D010024:Osteoporosis / Q000235:genetics / Q000378:metabolism; D011110:Polymorphism, Genetic; D017697:Premenopause; D018167:Receptors, Calcitriol / Q000235:genetics*
D018167:Receptors, Calcitriol