[Importance of urgent cerebrospinal fluid examination for early diagnosis of central nervous system infections].
To a certain extent, the cerebrospinal fluid (CSF) composition reflects the current status of the central nervous system (CNS). Therefore, studying changes in even the most essential CSF parameters provides enormous scope for obtaining valuable information about processes in the CNS in relation to its disorders. The article aims at presenting our current conception of urgent CSF examination with special emphasis on early diagnosis of central nervous infections. In particular, the focus is on evaluating energy conditions in the CSF compartment and permeability of the blood-brain and blood-CSF barriers, CSF cytology, detecting CNS tissue destruction and bleeding into CNS pathways and monitoring the levels of systemic inflammatory activity.
Kelbich
Petr
P
Department of Clinical Biochemistry and Haematology, Regional Hospital Kadan, Czech Republic. kelbich@nemkadan.cz
Koudelková
Martina
M
Machová
Hana
H
Tomaskovic
Miloslav
M
Vachata
Petr
P
Kotalíková
Patricie
P
Chmelíková
Vlasta
V
Hanuljaková
Eva
E
D015415:Biomarkers / Q000134:cerebrospinal fluid; D001812:Blood-Brain Barrier; D002494:Central Nervous System Infections / Q000134:cerebrospinal fluid / Q000175:diagnosis*; D002555:Cerebrospinal Fluid / Q000737:chemistry* / Q000166:cytology; D042241:Early Diagnosis; D004630:Emergencies; D004734:Energy Metabolism; D006801:Humans
D015415:Biomarkers