title: Asymmetric dynamic cerebral autoregulatory response to cyclic stimuli.
abstract: OBJECTIVE
  Dynamic cerebral autoregulation has been shown to be fast and effective, but it is not well known if the mechanism is symmetric, that is to say, it acts with equal compensatory action to upward as compared with downward abrupt changes in arterial blood pressure (ABP).
  
  
  METHODS
  Fourteen patients with head injuries and 10 normal subjects had bilateral transcranial Doppler and continuous ABP recording. Cyclic ABP stimuli were generated by large thigh cuffs, which were rapidly inflated above systolic pressure for 15 seconds alternating with 15 seconds of deflation. At least 8 such cycles were ensemble-averaged and the dynamic autoregulatory gain (AG(up) and AG(dn)) was estimated separately for upward and downward changes in ABP. The results were compared with the autoregulation index using conventional leg cuff releases.
  
  
  RESULTS
  In normal subjects, AG(dn) was 0.74+/-0.18 and AG(up) was 0.77+/-0.17 (mean+/-SD); the difference was insignificant. The correlation between AG(dn) and AG(up), however, was weak (r=0.24). In the patients with head injury, AG(dn) was 0.30+/-0.21 and AG(up) was 1.27+/-0.76, the difference being highly significant (P<0.001). There was a negative relationship between AG(dn) and AG(up) (r=-0.33). Autoregulation index correlated well with AG(dn) (r=0.79) and weakly negatively with AG(up) (r=-0.47).
  
  
  CONCLUSIONS
  A strongly asymmetric dynamic response of the cerebral autoregulation was seen the majority of patients with head injury. It might also have been present, albeit to a lesser degree, in the normal subjects. The findings suggest that nonlinear effects may be present in the operation of the cerebral autoregulation mechanism.
authors.affiliation: Department of Neurological Surgery, University of Washington School of Medicine, University of Washington Medical Center, Harborview Medical Center, Seattle, WA, USA.
authors.forename: Rune
authors.initials: R
authors.lastname: Aaslid
authors.forename: Martin
authors.initials: M
authors.lastname: Blaha
authors.forename: Gill
authors.initials: G
authors.lastname: Sviri
authors.forename: Colleen M
authors.initials: CM
authors.lastname: Douville
authors.forename: David W
authors.initials: DW
authors.lastname: Newell
mesh_terms: D000293:Adolescent; D000328:Adult; D001783:Blood Flow Velocity; D001794:Blood Pressure / Q000502:physiology; D002560:Cerebrovascular Circulation / Q000502:physiology*; D002648:Child; D005260:Female; D016489:Head Injuries, Closed / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017585:Ultrasonography, Doppler, Transcranial