title: Cerebral sinus occlusion in a boy presenting with asparaginase-induced hypertriglyceridemia.
abstract: Cerebral sinus thrombosis is a rare but severe complication during treatment for acute lymphoblastic leukaemia (ALL). It mostly has been reported during treatment with asparaginase and dexamethasone. Hypertriglyceridemia has - albeit very rarely - also been associated with asparaginase therapy. The combination of cerebral sinus thrombosis and hypertriglyceridemia however, has not yet been reported. Here we describe a 15-year-old boy who presented with clinical symptoms and radiologic findings of a cerebral sinus thrombosis. In addition, a life-threatening hypertriglyceridemia was present. The complication was successfully treated by anticoagulation with low molecular weight heparin and the lipid regulator bezafibrate.
authors.affiliation: Hospital for Children and Adolescents, University of Leipzig Medical Center, Leipzig, Germany.
authors.forename: V
authors.initials: V
authors.lastname: Dietel
authors.forename: P
authors.initials: P
authors.lastname: Bührdel
authors.forename: W
authors.initials: W
authors.lastname: Hirsch
authors.forename: D
authors.initials: D
authors.lastname: Körholz
authors.forename: W
authors.initials: W
authors.lastname: Kiess
mesh_terms: D000293:Adolescent; D000925:Anticoagulants; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000633:toxicity*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use / Q000633:toxicity*; D001215:Asparaginase / Q000008:administration & dosage / Q000633:toxicity*; D001629:Bezafibrate / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D006495:Heparin, Low-Molecular-Weight / Q000627:therapeutic use; D006801:Humans; D015228:Hypertriglyceridemia / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D000960:Hypolipidemic Agents / Q000627:therapeutic use; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000188:drug therapy*; D018810:Magnetic Resonance Angiography; D011092:Polyethylene Glycols / Q000008:administration & dosage / Q000633:toxicity*; D012851:Sinus Thrombosis, Intracranial / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy
chemical_list: D000925:Anticoagulants; D000970:Antineoplastic Agents; D006495:Heparin, Low-Molecular-Weight; D000960:Hypolipidemic Agents; D011092:Polyethylene Glycols; C042705:pegaspargase; D001215:Asparaginase; D001629:Bezafibrate