title: The economic implications of the racial and ethnic disparities in the use of selective serotonin reuptake inhibitors.
abstract: OBJECTIVE
  Previous studies have examined racial and ethnic disparities in the use of selective serotonin reuptake inhibitors (SSRI). This study aims to examine the economic implications of these disparities.
  
  
  METHODS
  In this retrospective observational study, the study sample was adult survey respondents with a diagnosis of depression from the Medical Expenditure Panel Survey (2002-2003). SSRI use was measured as the number of times when SSRIs were obtained. The racial and ethnic disparities in SSRI use were examined employing a negative binomial model. The economic implications of disparities were explored using a linear regression with SSRI use as an independent variable. Interaction terms between the variable for SSRI use and dummy variables for racial and ethnic groups were included to explore whether the relationships between SSRI use and health expenditures differ across racial and ethnic groups.
  
  
  RESULTS
  The mean number of times of SSRI use was higher for non-Hispanic whites than non-Hispanic blacks (3.02 vs. 1.79; p < 0.05) and Hispanic whites (3.02 vs. 1.68; p < 0.05). These differences were still significant after adjusting for covariates (p < 0.05). In the multivariate analysis, each time of SSRI use was associated with health expenditures of $301 higher. Neither dummy variables for racial and ethnic groups nor the interaction terms between these dummy variables and the variable for SSRI use were significant.
  
  
  CONCLUSIONS
  The lower use of SSRIs among minorities compared to non-Hispanic whites is associated with lower health expenditures among minorities. SSRI may be a proxy for improved access to health care due to under-treatment of depression in general. The main limitation of this study is that its observational nature does not allow the researchers to determine whether the association between SSRI use and the increase in health expenditures is a causal effect.
authors.affiliation: University of Tennessee College of Pharmacy, Memphis, Tennessee 38163, USA. jwang26@utmem.edu <jwang26@utmem.edu>
authors.forename: Junling
authors.initials: J
authors.lastname: Wang
authors.forename: Shelley I
authors.initials: SI
authors.lastname: White-Means
authors.forename: Meghan A
authors.initials: MA
authors.lastname: Hufstader
authors.forename: Genene D
authors.initials: GD
authors.lastname: Walker
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003863:Depression / Q000188:drug therapy / Q000191:economics* / Q000208:ethnology*; D004363:Drug Utilization; D005006:Ethnicity; D005260:Female; D019538:Health Care Surveys; D005102:Health Expenditures; D006801:Humans; D008297:Male; D008875:Middle Aged; D018803:Models, Economic; D044469:Racial Groups; D012189:Retrospective Studies; D017367:Selective Serotonin Reuptake Inhibitors / Q000191:economics* / Q000627:therapeutic use; D012959:Socioeconomic Factors
chemical_list: D017367:Selective Serotonin Reuptake Inhibitors