Rapid transit in the immune cells: the role of mRNA turnover regulation.
There have been recent, significant advances about the role of mRNA turnover in controlling gene expression in immune cells. Post-transcriptional regulation of gene expression contributes to the characteristics of many of the processes underlying the immune response by ensuring early, rapid, and transient action. The emphasis of this review is on current work that deals with the regulation of mRNA decay during innate immunity against microbes and T cell activation as a model of the adaptive response.
Khabar
Khalid S A
KS
Program in BioMolecular Research, King Faisal Specialist Hospital and Research Center, P3354, mBC-03, Riyadh 11211, Saudi Arabia. khabar@kfshrc.edu.sa
D000818:Animals; D016207:Cytokines / Q000096:biosynthesis; D005786:Gene Expression Regulation; D006801:Humans; D007110:Immunity, Active; D007113:Immunity, Innate; D008213:Lymphocyte Activation; D035683:MicroRNAs / Q000276:immunology; D020871:RNA Stability / Q000276:immunology*; D012330:RNA, Double-Stranded / Q000276:immunology; D012333:RNA, Messenger / Q000276:immunology*; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000276:immunology*; D048051:p38 Mitogen-Activated Protein Kinases / Q000276:immunology
D016207:Cytokines; D035683:MicroRNAs; D012330:RNA, Double-Stranded; D012333:RNA, Messenger; D048051:p38 Mitogen-Activated Protein Kinases