Prevention and treatment of aortic graft infection.
Prosthetic vascular graft infection remains one of the most challenging surgical problems for vascular surgeons. This condition is classically associated with high morbidity and mortality rates. Accurate diagnosis of a vascular graft infection can typically be made based on a thorough history and physical examination; although, infrequently, an extensive radiological evaluation is necessary to establish the clinical finding. Complete graft excision and extra-anatomic bypass grafting remains a commonly accepted surgical treatment strategy. Recent clinical data have supported other treatment modalities, including the use of in situ antibiotic-impregnated graft replacement, in situ allograft replacement and in situ autologous graft replacement. This article will review the pathobiology of aortic graft infection, as well as methods to prevent a prosthetic graft infection. Furthermore, various surgical treatment modalities of aortic graft infection will be discussed.
Mussa
Firas F
FF
The Michael E DeBakey VA Medical Center, Division of Vascular Surgery & Endovascular Therapy, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX, USA. fmussa@bcm.edu
Hedayati
Nasim
N
Zhou
Wei
W
El-Sayed
Hosam F
HF
Kougias
Panagiotis
P
Darouiche
Rabih O
RO
Lin
Peter H
PH
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use; D001011:Aorta / Q000382:microbiology / Q000637:transplantation*; D001424:Bacterial Infections / Q000188:drug therapy / Q000209:etiology / Q000517:prevention & control*; D006801:Humans; D019737:Transplants / Q000009:adverse effects / Q000382:microbiology; D014656:Vascular Surgical Procedures / Q000009:adverse effects
D000900:Anti-Bacterial Agents