Triterpenoid saponins with N-acetyl sugar from the bark of Albizia procera.
Three (1,2,4) and one known (3) triterpenoid saponins were isolated from the bark of Albizia procera. The saponins were characterized as 3-O-[beta-D-xylopyranosyl-(1-->2)-alpha-L-arabinopyranosyl-(1-->6)-2-acetamido-2-deoxy-beta-D-glucopyranosyl] echinocystic acid (1), 3-O-[alpha-L-arabinopyranosyl-(1-->2)-beta-D-fucopyranosyl-(1-->6)-2-acetamido-2-deoxy-beta-D-glucopyranosyl] echinocystic acid (2) and 3-O-[beta-D-xylopyranosyl-(1-->2)-alpha-L-arabinopyranosyl-(1-->6)-2-acetamido-2-deoxy-beta-D-glucopyranosyl] acacic acid lactone (4). Their structures were elucidated by 1D and 2D NMR experiments, FABMS as well as chemical means. Saponins 1 and 3 exhibited cytotoxicity against HEPG2 cell line with IC50 9.13 microg/ml and 10 microg/ml, respectively.
Melek
F R
FR
Chemistry of Natural Compounds Department, National Research Center, Dokki 12622, Giza, Egypt. frmelek@link.net
Miyase
Toshio
T
Ghaly
N S
NS
Nabil
Marian
M
D031289:Albizzia / Q000737:chemistry*; D002241:Carbohydrates / Q000737:chemistry*; D045744:Cell Line, Tumor; D006801:Humans; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry* / Q000302:isolation & purification* / Q000633:toxicity; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification*
D002241:Carbohydrates; D012503:Saponins; D014315:Triterpenes