title: Drinking capacity and severity of dyspeptic symptoms during a water load test after Nissen fundoplication.
abstract: Up to 30% of subjects undergoing Nissen fundoplication develop dyspeptic symptoms. Previous studies using the water load test have shown that functional dyspepsia patients have a diminished drinking capacity due to increased visceral sensitivity. Here we investigate drinking capacity and severity of symptoms in 9 patients with dyspeptic symptoms after fundoplication, 9 patients without symptoms after surgery, 18 functional dyspepsia patients, and 18 controls. The water load test was performed by having subjects drinking room-temperature tap water at a predetermined rate of 15 ml/min. The presence and severity of symptoms during the test were evaluated every 5 min using a Likert scale. We found that patients with dyspeptic symptoms after fundoplication had a significantly lower drinking capacity and higher symptoms scores than controls (P<0.05) but values similar to those of functional dyspepsia patients (P>0.05). In contrast, drinking capacity in patients without symptoms after surgery was similar to that in controls (P>0.05). These findings suggest that, as in functional dyspepsia, severe dyspeptic symptoms after Nissen fundoplication are associated with an impaired drinking capacity, reflecting visceral hypersensitivity or impaired gastric accommodation or both.
authors.affiliation: Department of Gastroenterology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga 15, Colonia Sección XVI, CP 14000, México, DF, México. chemaremes@hotmail.com
authors.forename: Jose María
authors.initials: JM
authors.lastname: Remes-Troche
authors.forename: Aldo
authors.initials: A
authors.lastname: Montaño-Loza
authors.forename: Julio César
authors.initials: JC
authors.lastname: Martínez
authors.forename: Miguel
authors.initials: M
authors.lastname: Herrera
authors.forename: Miguel Angel
authors.initials: MA
authors.lastname: Valdovinos-Díaz
mesh_terms: D000328:Adult; D004326:Drinking / Q000502:physiology*; D004415:Dyspepsia / Q000209:etiology / Q000503:physiopathology*; D005260:Female; D018662:Fundoplication / Q000009:adverse effects*; D005764:Gastroesophageal Reflux / Q000601:surgery; D006801:Humans; D008297:Male; D011183:Postoperative Complications; D011379:Prognosis; D012720:Severity of Illness Index; D014867:Water
chemical_list: D014867:Water