Modeling Maternal-Infant HIV Transmission in the Presence of Breastfeeding with an Imperfect Test.
An important public health question is to determine the probabilities of perinatal HIV transmission and when it occurs, whether antepartum, intrapartum, or postpartum through breastfeeding. However, this is a difficult problem because the presence of HIV infection in an infant can only be ascertained through viral assays in the postpartum period. We propose a model that simultaneously estimates the risks of antepartum, intrapartum, and postpartum transmissions together with the sensitivity of the screening tests for HIV infection. The model allows estimating of infectivity through breast milk during postpartum periods. The methods are illustrated on a South African randomized clinical trial of extended AZT versus a short course of nevirapine in infants whose mothers had no access to antenatal antiretroviral therapy.
Gupte
N
N
JHU-BJMC MIT Study, Pathology Museum, BJ Medical College and Sassoon General Hospitals, Sassoon Road, Pune 411001, India. nikhil@jhumitpune.com
Brookmeyer
R
R
Bollinger
R
R
Gray
G
G
D001942:Breast Feeding / Q000453:epidemiology*; D003198:Computer Simulation; D003627:Data Interpretation, Statistical; D005260:Female; D015658:HIV Infections / Q000453:epidemiology*; D006801:Humans; D018445:Infectious Disease Transmission, Vertical / Q000706:statistics & numerical data*; D008431:Maternal-Fetal Exchange; D008954:Models, Biological; D015233:Models, Statistical; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000453:epidemiology*; D016032:Randomized Controlled Trials as Topic; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D013019:South Africa / Q000453:epidemiology