Two successful pregnancies in a chronic myeloid leukemia patient treated with imatinib.
The number of CML patients in child-bearing age and treated with imatinib is increasing. These women may want to be pregnant or are actually pregnant while on imatinib. Physicians do not know when to stop the treatment and what the risks are for the foetus and the mother. We report a case of a CML patient treated with imatinib who has two children, now 3 years and 10 months of age, in good health. The mother was in complete molecular remission, relapsed during pregnancy and reverted to remission in both cases after delivery.
Garderet
Laurent
L
Department of Hematology, Saint Antoine Hospital, Paris, France.
Santacruz
Rodrigo
R
Barbu
Veronique
V
van den Akker
Jacqueline
J
Carbonne
Bruno
B
Gorin
Norbert Claude
NC
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D001549:Benzamides; D001942:Breast Feeding; D003561:Cytarabine / Q000008:administration & dosage; D047108:Embryonic Development / Q000187:drug effects*; D005260:Female; D006801:Humans; D000068877:Imatinib Mesylate; D007155:Immunologic Factors / Q000627:therapeutic use; D007372:Interferons / Q000627:therapeutic use; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy*; D010879:Piperazines / Q000008:administration & dosage / Q000494:pharmacology*; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000188:drug therapy*; D011256:Pregnancy Outcome; D011743:Pyrimidines / Q000008:administration & dosage / Q000494:pharmacology*; D012008:Recurrence; D012074:Remission Induction
D001549:Benzamides; D007155:Immunologic Factors; D010879:Piperazines; D011743:Pyrimidines; D003561:Cytarabine; D000068877:Imatinib Mesylate; D007372:Interferons