Serotonergic response to stress: a protective factor against abnormal dopaminergic reactivity in schizophrenia?
In a double-blind-crossover-study, 10 patients with schizophrenia, 10 of their unaffected siblings and 9 healthy controls randomly received metabolic stressor and placebo. A significant HVA plasma elevation in response to stress was found in siblings whose response was intermediate to that of patients and controls. Only siblings additionally displayed an exaggerated 5HIAA response.
Brunelin
Jerome
J
Université de Lyon, Lyon, F-69003, France. jerome.brunelin@ch-le-vinatier.fr
D'amato
Thierry
T
van Os
Jim
J
Dalery
Jean
J
Suaud-Chagny
Marie-Françoise
MF
Saoud
Mohamed
M
D000328:Adult; D000963:Antimetabolites; D001143:Arousal / Q000235:genetics; D018592:Cross-Over Studies; D003847:Deoxyglucose; D004298:Dopamine / Q000502:physiology*; D004311:Double-Blind Method; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006719:Homovanillic Acid / Q000097:blood*; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000097:blood*; D008297:Male; D012016:Reference Values; D012307:Risk Factors; D012559:Schizophrenia / Q000097:blood* / Q000235:genetics; D012569:Schizotypal Personality Disorder / Q000097:blood / Q000235:genetics; D035781:Siblings; D012931:Social Environment; D013312:Stress, Physiological / Q000097:blood / Q000150:complications*
D000963:Antimetabolites; D006897:Hydroxyindoleacetic Acid; D003847:Deoxyglucose; D004298:Dopamine; D006719:Homovanillic Acid