title: Systemic d-phenylalanine and d-leucine for effective treatment of pain in the horse.
abstract: This study showed that subcutaneous injection of a solution of D-amino acids produced effective analgesia in horses. It is postulated that systemic D-phenylalanine and D-leucine may become one of the safe, effective and nonaddictive drugs for acute and chronic pain treatment. These D-amino acids cause analgesia by presumably preserving brain endorphins. They may bind reversibly to enkephalinases and prevent enzymatic degradation of enkephalins.
authors.forename: L S
authors.initials: LS
authors.lastname: McKibbin
authors.forename: R S
authors.initials: RS
authors.lastname: Cheng