The role of intragenomic recombination rate in the evolution of population's genetic pool.
In a simple computer model of population evolution, we have shown that frequency of recombination between haplotypes during the gamete production influences the effectiveness of the reproduction strategy. High recombination rates keeps the fraction of defective alleles low while low recombination rate or uneven distributed recombination spots change the strategy of genomes' evolution and result in the accumulation of heterozygous loci in the genomes. Even short fragment of chromosome with restricted recombination influences the genetic structure of neighboring regions.
Zawierta
Marta
M
Department of Genomics, Wrocław University, ul. Przybyszewskiego 63/77, 51-148 Wrocław, Poland.
Biecek
Przemysław
P
Waga
Wojciech
W
Cebrat
Stanisław
S
D005075:Biological Evolution; D003198:Computer Simulation; D005260:Female; D014644:Genetic Variation; D005828:Genetics, Population / Q000379:methods*; D006239:Haplotypes; D006801:Humans; D008297:Male; D008957:Models, Genetic; D009010:Monte Carlo Method; D011995:Recombination, Genetic