title: Fine-needle aspiration cytology of apocrine adenosis of the breast: report on three cases.
abstract: Apocrine adenosis is a distinctive breast lesion, which can sometimes be misdiagnosed as malignant histologically. Although its histological characteristics have been well established, there are limited descriptions of its cytological features. We report fine-needle aspiration (FNA) cytology of three cases of apocrine adenosis. There were diverse cytological features between cases, and in two cases, FNA smears were highly cellular. Naked nuclei were present in all cases, and were numerous in one. Enlarged nucleoli and anisonucleosis were common. Apocrine metaplasia with nuclear atypia mimicking apocrine carcinoma was prominent in one case, whereas one case lacked definite apocrine features. Regardless of their various atypical FNA cytologies, the nuclei were consistently less hyperchromatic in all cases. Although FNA cytology of apocrine adenosis has the potential to be misinterpreted as malignant, the naked nuclei of background and less hyperchromatic nuclear features may be useful in distinguishing apocrine adenosis from carcinoma. Being familiar with these distinctive breast lesions is also important in decreasing false positives.
authors.affiliation: Pathology Division, Fukushima Medical University School of Medicine Hospital, Fukushima, Japan. w-kazuo@fmu.ac.jp
authors.forename: Kazuo
authors.initials: K
authors.lastname: Watanabe
authors.forename: Mizuko
authors.initials: M
authors.lastname: Nomura
authors.forename: Yuko
authors.initials: Y
authors.lastname: Hashimoto
authors.forename: Miyoko
authors.initials: M
authors.lastname: Hanzawa
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Hoshi
mesh_terms: D000328:Adult; D044963:Biopsy, Fine-Needle / Q000379:methods*; D001943:Breast Neoplasms / Q000473:pathology; D002467:Cell Nucleus / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D005348:Fibrocystic Breast Disease / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008875:Middle Aged; D016896:Treatment Outcome