title: Tumor necrosis factor is critical to control tuberculosis infection.
abstract: Tumor necrosis factor (TNF) is critical and non-redundant to control Mycobacterium tuberculosis infection and cannot be replaced by other proinflammatory cytokines. Overproduction of TNF may cause immunopathology, while TNF neutralization reactivates latent and chronic, controlled infection, which is relevant for the use of neutralizing TNF therapies in patients with rheumatoid arthritis.
authors.affiliation: Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
authors.forename: Muazzam
authors.initials: M
authors.lastname: Jacobs
authors.forename: Dieudonnée
authors.initials: D
authors.lastname: Togbe
authors.forename: Cecile
authors.initials: C
authors.lastname: Fremond
authors.forename: Arina
authors.initials: A
authors.lastname: Samarina
authors.forename: Nasiema
authors.initials: N
authors.lastname: Allie
authors.forename: Tania
authors.initials: T
authors.lastname: Botha
authors.forename: Daniela
authors.initials: D
authors.lastname: Carlos
authors.forename: Shreemanta K
authors.initials: SK
authors.lastname: Parida
authors.forename: Sergei
authors.initials: S
authors.lastname: Grivennikov
authors.forename: Sergei
authors.initials: S
authors.lastname: Nedospasov
authors.forename: Analbery
authors.initials: A
authors.lastname: Monteiro
authors.forename: Marc
authors.initials: M
authors.lastname: Le Bert
authors.forename: Valerie
authors.initials: V
authors.lastname: Quesniaux
authors.forename: Bernhard
authors.initials: B
authors.lastname: Ryffel
mesh_terms: D000818:Animals; D006801:Humans; D009169:Mycobacterium tuberculosis / Q000276:immunology / Q000502:physiology*; D014376:Tuberculosis / Q000276:immunology* / Q000503:physiopathology; D048069:Tumor Necrosis Factors / Q000172:deficiency / Q000276:immunology / Q000502:physiology*
chemical_list: D048069:Tumor Necrosis Factors