9-(2-C-Cyano-2-deoxy-beta-D-arabino-pentofuranosyl)guanine, a potential antitumor agent against B-lymphoma infected with Kaposi's sarcoma-associated herpesvirus.
Several 9-(2-C-cyano-2-deoxy-l-beta-d-arabino-pentofuranosyl)purine derivatives were tested against Kaposi's sarcoma-associated herpesvirus (KSHV)-infected primary effusion lymphoma (PEL) cells. The guanine derivative (3, CNDAG), as well as the 2-amino-6-substituted-purine derivatives 4, 5, and 6, exhibited cell growth inhibitory activity against KSHV-infected cells, but showed no cytotoxicity against KSHV-negative cells at >15 microM concentrations. Therefore, it was found that compounds 3, 4, 5, and 6 showed selective cytotoxicity against PEL cells infected with KSHV.
Ohtawa
Masaki
M
Department of Medicinal Chemistry and Biological Chemistry, Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-ku, Kita-12, Nishi-6, Sapporo 060-0812, Japan.
Ichikawa
Satoshi
S
Teishikata
Yasuhiro
Y
Fujimuro
Masahiro
M
Yokosawa
Hideyoshi
H
Matsuda
Akira
A
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001087:Arabinonucleosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D004247:DNA / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D020031:Epstein-Barr Virus Infections / Q000150:complications; D006151:Guanosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D006566:Herpesviridae Infections / Q000150:complications*; D019288:Herpesvirus 8, Human; D006801:Humans; D016393:Lymphoma, B-Cell / Q000150:complications*; D012313:RNA / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D013329:Structure-Activity Relationship
C520639:9-(2-C-cyano-2-deoxy-arabino-pentofuranosyl)guanine; D000970:Antineoplastic Agents; D001087:Arabinonucleosides; D006151:Guanosine; D012313:RNA; D004247:DNA