title: Clinical symptomatology and paranasal sinus involvement with nasal septal perforation.
abstract: OBJECTIVE
  Determine the symptom manifestations, clinical impact, and incidence of chronic rhinosinusitis (CRS) in patients with newly diagnosed nasal septal perforation.
  
  
  METHODS
  A consecutive series of adult patients with nasal septal perforation were prospectively studied at the time of endoscopic diagnosis with the rhinosinusitis symptom inventory (RSI) and sinus computed tomography (CT). Patients' symptoms in the RSI symptom domains were computed. From the CT scan, septal perforation size and Lund scores were obtained. A separate (control) cohort of patients with CRS without septal perforation was matched to these patients for age, sex, and Lund score. RSI symptom domain comparisons were conducted between groups to determine the additional symptom burden conferred by septal perforation.
  
  
  RESULTS
  Thirty-three patients with septal perforation were enrolled (mean age, 48.2 yr; 69.7% female). Mean perforation size was 1.9 (SD, 2.1) cm. The mean Lund score was 5.8 (SD, 5.3); 16 (57.1%) patients met radiographic criteria for a concurrent diagnoses of CRS. Patients with septal perforation reported significant nasal and facial symptom domain scores (56.8 and 47.0, respectively [range, 0-100]). Oropharyngeal and systemic symptoms were less severe (29.7 and 34.7, respectively). However, after comparison with the matched control patients, no statistically significant differences were identified in sinonasal symptoms between patients with and without septal perforation (all P > .131).
  
  
  CONCLUSIONS
  Concurrent CRS may frequently accompany nasal septal perforation and may require appropriate treatment along with the perforation itself. The presence of septal perforation does not appear to significantly augment symptom severity in CRS.
authors.affiliation: Division of Otolaryngology, Brigham and Women's Hospital, Boston, Massachusetts, and the Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts, USA. neiloy@massmed.org
authors.forename: Neil
authors.initials: N
authors.lastname: Bhattacharyya
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D009300:Nasal Septum / Q000000981:diagnostic imaging / Q000293:injuries*; D011446:Prospective Studies; D011788:Quality of Life / Q000523:psychology; D012720:Severity of Illness Index; D012852:Sinusitis / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology*; D014057:Tomography, X-Ray Computed; D014947:Wounds and Injuries / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology*