A dimeric lactone from Ardisia japonica with inhibitory activity for HIV-1 and HIV-2 ribonuclease H.
A new dimeric lactone, ardimerin digallate (1), was isolated from the whole plants of Ardisia japonica, along with six known constituents. The structure of 1 was established on the basis of spectroscopic analysis including 1D- and 2D-NMR techniques. Compound 1 inhibited HIV-1 and HIV-2 RNase H in vitro with IC50 values of 1.5 and 1.1 microM, respectively.
Dat
Nguyen Tien
NT
College of Pharmacy, Chungnam National University, Daejeon 305-764, Korea.
Bae
KiHwan
K
Wamiru
Antony
A
McMahon
James B
JB
Le Grice
Stuart F J
SF
Bona
Marion
M
Beutler
John A
JA
Kim
Young Ho
YH
D019380:Anti-HIV Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D031644:Ardisia / Q000737:chemistry*; D015497:HIV-1 / Q000201:enzymology*; D015498:HIV-2 / Q000201:enzymology*; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*; D016914:Ribonuclease H / Q000037:antagonists & inhibitors*
D019380:Anti-HIV Agents; D007783:Lactones; C521075:ardimerin digallate; D016914:Ribonuclease H