title: [ssociation of HLA class I and II alleles with generalized vitiligo in Chinese Hans in north China].
abstract: OBJECTIVE
  To investigate the association of HLA class I and II alleles with generalized vitiligo in ethnic Han Chinese in north China.
  
  
  METHODS
  By employing polymerase chain reaction sequence-specific primer (PCR-SSP) procedure 34 generalized vitiligo patients in north China were studied for HLA I and II alleles and were compared with 102 healthy controls.
  
  
  RESULTS
  The allelic frequencies of HLA-A*30, Cw*06, DRB1*07, and DQB1*0201 were increased significantly in generalized vitiligo and especially in the patients without family history compared with the controls.
  
  
  CONCLUSIONS
  These alleles positively associated with generalized vitiligo in Chinese Han patients in north China, might provide clues to reveal the susceptibility gene(s) of vitiligo in Chinese and as well as the immunnogenetic mechanisms of disease.
authors.affiliation: Department of Dermatology, No.1 Hospital of China Medical University, Shenyang, Liaoning, 110001 PR China.
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.forename: Yu-ming
authors.initials: YM
authors.lastname: Zhao
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.forename: Yi
authors.initials: Y
authors.lastname: Xiao
authors.forename: Ya-kun
authors.initials: YK
authors.lastname: Wang
authors.forename: Hong-duo
authors.initials: HD
authors.lastname: Chen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D044466:Asian People / Q000235:genetics; D002681:China; D005260:Female; D005787:Gene Frequency; D005805:Genes, MHC Class I / Q000235:genetics*; D005802:Genes, MHC Class II / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D014820:Vitiligo / Q000208:ethnology / Q000235:genetics*