Vogt-Koyanagi-Harada syndrome in a case of multiple sclerosis.
A 34-year-old woman in whom multiple sclerosis (MS) had been diagnosed 2 years earlier developed progressive bilateral visual loss associated with peripapillary exudative retinal detachment and other features of Vogt-Koyanagi-Harada (VKH) syndrome. She was treated with corticosteroid pulses and interferon beta-1A with visual acuity improvement and resolution of the retinal detachment. This is the first reported case of VKH syndrome in a patient with MS. The combination of VKH syndrome and MS suggests a common autoimmune pathogenesis.
Montero
Javier A
JA
VISSUM, Instituto Oftalmológico de Alicante, Retina Unit, Alicante, Spain. msm02va@wanadoo.es
Sanchis
M Eugenia
ME
Fernandez-Munoz
Marta
M
D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000627:therapeutic use; D000328:Adult; D003937:Diagnosis, Differential; D018450:Disease Progression; D004333:Drug Administration Routes; D004359:Drug Therapy, Combination; D005260:Female; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D005938:Glucocorticoids / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D000068556:Interferon beta-1a; D016899:Interferon-beta / Q000008:administration & dosage / Q000627:therapeutic use; D008279:Magnetic Resonance Imaging; D009103:Multiple Sclerosis / Q000150:complications* / Q000175:diagnosis; D041623:Tomography, Optical Coherence; D014607:Uveomeningoencephalitic Syndrome / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D014792:Visual Acuity
D000276:Adjuvants, Immunologic; D005938:Glucocorticoids; D016899:Interferon-beta; D000068556:Interferon beta-1a