title: Effect of mesenchymal stem cell transplantation on cognitive functions in rats with ischemic stroke.
abstract: The effect of intravenous transplantation of mesenchymal stem cells on the recovery of cognitive functions was studied in Wistar-Kyoto rats after brain stroke induced by occlusion of the middle cerebral artery in the left hemisphere. Analysis 2 and 5 weeks after stroke showed that transplantation of mesenchymal stem cells 3 days after middle cerebral artery occlusion reduced the area of cerebral injury, preserved cognitive functions, and decreased mortality in experimental animals.
authors.affiliation: Trans-Tekhnologiya Company, Russian Academy of Medical Sciences, St. Petersburg.
authors.forename: I B
authors.initials: IB
authors.lastname: Sokolova
authors.forename: O R
authors.initials: OR
authors.lastname: Fedotova
authors.forename: N N
authors.initials: NN
authors.lastname: Zin'kova
authors.forename: P V
authors.initials: PV
authors.lastname: Kruglyakov
authors.forename: D G
authors.initials: DG
authors.lastname: Polyntsev
mesh_terms: D000818:Animals; D002545:Brain Ischemia / Q000503:physiopathology* / Q000523:psychology / Q000628:therapy*; D003071:Cognition / Q000502:physiology*; D004195:Disease Models, Animal; D005434:Flow Cytometry; D008297:Male; D018782:Maze Learning; D045164:Mesenchymal Stem Cell Transplantation; D020768:Middle Cerebral Artery / Q000601:surgery; D051381:Rats; D011921:Rats, Inbred WKY; D012016:Reference Values; D013550:Swimming