title: Novel lbeta-methylcarbapenems having cyclic sulfonamide moieties: synthesis and evaluation of in vitro antibacterial activity.
abstract: The synthesis of a new series of 1beta-methylcarbapenems having cyclic sulfonamide moieties is described. Their in vitro antibacterial activities against both Gram-positive and Gram-negative bacteria were tested and the effect of substituent on the pyrrolidine ring was investigated. A particular compound (IIIi) having 2-methyl-[1,2,6]thiadiazinan-1,1-dioxide moiety showed the most potent antibacterial activity.
authors.affiliation: Medicinal Chemistry Research Center, Korea Institute of Science and Technology, Seoul 130-650, South Korea.
authors.forename: Seong Jong
authors.initials: SJ
authors.lastname: Kim
authors.forename: Hyeong Beom
authors.initials: HB
authors.lastname: Park
authors.forename: Jae Seoung
authors.initials: JS
authors.lastname: Lee
authors.forename: Nam Hyun
authors.initials: NH
authors.lastname: Jo
authors.forename: Kyung Ho
authors.initials: KH
authors.lastname: Yoo
authors.forename: Daejin
authors.initials: D
authors.lastname: Baek
authors.forename: Byoung-Won
authors.initials: BW
authors.lastname: Kang
authors.forename: Jung-Hyuck
authors.initials: JH
authors.lastname: Cho
authors.forename: Chang-Hyun
authors.initials: CH
authors.lastname: Oh
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015780:Carbapenems / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D000900:Anti-Bacterial Agents; D015780:Carbapenems