title: Constituents of Oxandra cf. xylopioides with anti-inflammatory activity.
abstract: A new triterpenoid (1) derived from 24-methylcycloartanol was isolated from the leaves of Oxandra cf. xylopioides. An unusual structure of the new compound was assigned as 1, for which the name berenjenol is proposed, on the basis of the spectroscopic data of the natural product and of its derivatives 2 and 3. The leaves also afforded the known monoterpene isoespintanol (4). Compounds 1 and 4 significantly reduced the paw edema induced by carrageenan by 64% and 43%, at 3 h, respectively. Moreover, 4 reduced IL-1 beta production by 72% at 100 microM and reduced IL-1 beta mRNA synthesis.
authors.affiliation: Laboratorio Ciencia de los Alimentos, Escuela de Química, Universidad Nacional de Colombia, Sede Medellín, A.A 3840, Medellín, Colombia.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Rojano
authors.forename: Edwin
authors.initials: E
authors.lastname: Pérez
authors.forename: Bruno
authors.initials: B
authors.lastname: Figadère
authors.forename: Marie Thérèse
authors.initials: MT
authors.lastname: Martin
authors.forename: María C
authors.initials: MC
authors.lastname: Recio
authors.forename: Rosa
authors.initials: R
authors.lastname: Giner
authors.forename: José L
authors.initials: JL
authors.lastname: Ríos
authors.forename: Guillermo
authors.initials: G
authors.lastname: Schinella
authors.forename: Jairo
authors.initials: J
authors.lastname: Sáez
mesh_terms: D000818:Animals; D029061:Annonaceae / Q000737:chemistry*; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002351:Carrageenan / Q000494:pharmacology; D003105:Colombia; D004487:Edema / Q000139:chemically induced*; D053583:Interleukin-1beta / Q000096:biosynthesis* / Q000187:drug effects; D051379:Mice; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D000893:Anti-Inflammatory Agents; D053583:Interleukin-1beta; D014315:Triterpenes; C521026:berenjenol; D002351:Carrageenan