title: Early treatment with arteriovenous extracorporeal lung assist and high-frequency oscillatory ventilation in a case of severe acute respiratory distress syndrome.
abstract: BACKGROUND
  Lung protective ventilation can reduce mortality in acute respiratory distress syndrome (ARDS). However, many patients with severe ARDS remain hypoxemic and more aggressive ventilation is necessary to maintain sufficient gas exchange. Pumpless arteriovenous extracorporeal lung assist (av-ECLA) has been shown to remove up to 95% of the systemic CO(2) production, thereby allowing ventilator settings and modes prioritizing oxygenation and lung protection. High-frequency oscillatory ventilation (HFOV) is an alternative form of ventilation that may improve oxygenation while limiting the risk of further lung injury by using extremely small tidal volumes (VT).
  
  
  METHODS
  We discuss the management of a patient suffering from severe ARDS as a result of severe bilateral lung contusions and pulmonary aspiration.
  
  
  RESULTS
  Severe ARDS developed within 4 h after intensive care unit admission. Conventional mechanical ventilation (CV) with high-airway pressures and low VT failed to improve gas exchange. Av-ECLA was initiated to achieve a less aggressive ventilation strategy. VT was reduced to 2-3 ml/kg, but oxygenation did not improve and airway pressures remained high. HFOV (8-10 Hz) was started using a recruitment strategy and oxygenation improved within 2 h. After 5 days, the patient was switched back to CV uneventfully and av-ECLA was removed after 8 days.
  
  
  CONCLUSIONS
  The combination of two innovative treatment modalities resulted in rapid stabilization and improvement of gas exchange during severe ARDS refractory to conventional lung protective ventilation. During av-ECLA, extremely high oscillatory frequencies were used minimizing the risk of baro- and volutrauma.
authors.affiliation: Department of Anaesthesiology, University of Wuerzburg, Wuerzburg, Germany. muellenbac_r@klinik.uni-wuerzburg.de
authors.forename: R M
authors.initials: RM
authors.lastname: Muellenbach
authors.forename: C
authors.initials: C
authors.lastname: Wunder
authors.forename: D C
authors.initials: DC
authors.lastname: Nuechter
authors.forename: T
authors.initials: T
authors.lastname: Smul
authors.forename: H
authors.initials: H
authors.lastname: Trautner
authors.forename: M
authors.initials: M
authors.lastname: Kredel
authors.forename: N
authors.initials: N
authors.lastname: Roewer
authors.forename: J
authors.initials: J
authors.lastname: Brederlau
mesh_terms: D000063:Accidents, Traffic; D000328:Adult; D005112:Extracorporeal Circulation; D006612:High-Frequency Ventilation / Q000379:methods; D006801:Humans; D008297:Male; D012128:Respiratory Distress Syndrome / Q000209:etiology / Q000628:therapy*; D016896:Treatment Outcome