Human lung density is not altered following normoxic and hypoxic moderate-intensity exercise: implications for transient edema.
The purpose of this study was to examine the effects of exercise on extravascular lung water as it may relate to pulmonary gas exchange. Ten male humans underwent measures of maximal oxygen uptake (Vo2 max) in two conditions: normoxia (N) and normobaric hypoxia of 15% O2 (H). Lung density was measured by quantified MRI before and 48.0 +/- 7.4 and 100.7 +/- 15.1 min following 60 min of cycling exercise in N (intensity = 61.6 +/- 9.5% Vo2 max) and 55.5 +/- 9.8 and 104.3 +/- 9.1 min following 60 min cycling exercise in H (intensity = 65.4 +/- 7.1% hypoxic Vo2 max), where Vo2 max = 65.0 +/- 7.5 ml x kg(-1) x min(-1) (N) and 54.1 +/- 7.0 ml x kg(-1) x min(-1) (H). Two subjects demonstrated mild exercise-induced arterial hypoxemia (EIAH) [minimum arterial oxygen saturation (SaO2 min) = 94.5% and 93.8%], and seven subjects demonstrated moderate EIAH (SaO2 min = 91.4 +/- 1.1%) as measured noninvasively during the Vo2 max test in N. Mean lung densities, measured once preexercise and twice postexercise, were 0.177 +/- 0.019, 0.181 +/- 0.019, and 0.173 +/- 0.019 g/ml (N) and 0.178 +/- 0.021, 0.174 +/- 0.022, and 0.176 +/- 0.019 g/ml (H), respectively. No significant differences (P > 0.05) were found in lung density following exercise in either condition or between conditions. Transient interstitial pulmonary edema did not occur following sustained steady-state cycling exercise in N or H, indicating that transient edema does not result from pulmonary capillary leakage during sustained submaximal exercise.
Hodges
Alastair N H
AN
Allan McGavin Sports Medicine Centre, University of British Columbia, Vancouver, British Columbia, Canada. alastairhodges@hotmail.com
Sheel
A William
AW
Mayo
John R
JR
McKenzie
Donald C
DC
D000328:Adult; D015444:Exercise; D015633:Extravascular Lung Water / Q000378:metabolism*; D006801:Humans; D000860:Hypoxia / Q000150:complications / Q000209:etiology* / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D008168:Lung / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D008279:Magnetic Resonance Imaging; D008297:Male; D010101:Oxygen Consumption; D011654:Pulmonary Edema / Q000150:complications / Q000209:etiology / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D011659:Pulmonary Gas Exchange; D015203:Reproducibility of Results; D012129:Respiratory Function Tests; D013997:Time Factors