A practical Buchwald-Hartwig amination of 2-bromopyridines with volatile amines.
A practical Buchwald-Hartwig amination of 2-bromopyridines with volatile amines is developed in sealed tubes. The method provides an expedient entry to a variety of secondary and tertiary aminopyridines that are otherwise not readily synthesized.
Li
Jie Jack
JJ
Department of Chemistry, Michigan Laboratories, Pfizer Global Research & Development, Ann Arbor, Michigan 48105, USA. jack.li@pfizer.com
Wang
Zhi
Z
Mitchell
Lorna H
LH
D000588:Amines / Q000737:chemistry*; D002625:Chemistry, Organic / Q000379:methods*; D011725:Pyridines / Q000737:chemistry; D014835:Volatilization
D000588:Amines; D011725:Pyridines; C023666:pyridine