title: Role of receptor and nonreceptor protein tyrosine kinases in H2O2-induced PKB and ERK1/2 signaling.
abstract: Excessive generation of reactive oxygen species (ROS) has been implicated in the pathogenesis of many diseases, including atherosclerosis, hypertension, and vascular complications of diabetes. However, the precise mechanisms by which ROS contribute to the development of these diseases are not fully characterized. Hydrogen peroxide (H2O2), a ROS, has been shown to activate several signaling protein kinases, such as extracellular signal-regulated kinase (ERK)1/2 and protein kinase B (PKB) in different cell types, notably in vascular smooth muscle cells. Because these pathways regulate cellular mitogenesis, migration, proliferation, survival, and death responses, their aberrant activation has been suggested to be a potential mechanism of ROS-induced pathologies. The upstream elements responsible for H2O2-induced ERK1/2 and PKB activation remain poorly characterized, but a potential role of receptor and nonreceptor protein tyrosine kinases (PTKs) as triggers that initiate such events has been postulated. Therefore, the aim of this review is to highlight the involvement of receptor and nonreceptor PTKs in modulating H2O2-induced ERK1/2 and PKB signaling.
authors.affiliation: Laboratory of Cell Signaling, Research Centre, Centre hospitalier de l'Université de Montréal-Technopole Angus, Université de Montréal, Montreal (Quebec) Canada.
authors.forename: Mohamad Z
authors.initials: MZ
authors.lastname: Mehdi
authors.forename: Zeina M
authors.initials: ZM
authors.lastname: Azar
authors.forename: Ashok K
authors.initials: AK
authors.lastname: Srivastava
mesh_terms: D000818:Animals; D002450:Cell Communication; D051418:Focal Adhesion Kinase 2 / Q000378:metabolism; D006801:Humans; D006861:Hydrogen Peroxide / Q000737:chemistry*; D019950:Mitogen-Activated Protein Kinase 1 / Q000378:metabolism; D048052:Mitogen-Activated Protein Kinase 3 / Q000378:metabolism; D008954:Models, Biological; D011392:Proline / Q000737:chemistry; D017027:Protein Tyrosine Phosphatases / Q000378:metabolism; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism; D017382:Reactive Oxygen Species; D011972:Receptor, Insulin / Q000378:metabolism; D015398:Signal Transduction; D015533:Transcriptional Activation
chemical_list: D017382:Reactive Oxygen Species; D011392:Proline; D006861:Hydrogen Peroxide; D011972:Receptor, Insulin; D051418:Focal Adhesion Kinase 2; D051057:Proto-Oncogene Proteins c-akt; D019950:Mitogen-Activated Protein Kinase 1; D048052:Mitogen-Activated Protein Kinase 3; D017027:Protein Tyrosine Phosphatases