title: Histomorphometric analysis of tissue responses to bioactive glass implants in critical defects in rat calvaria.
abstract: The aim of this study was to evaluate the osteogenic behavior of two chemically similar bioactive glass products (Biogranand Perioglas) implanted in critical bone defects in rat calvaria. Thirty-six transfixed bone defects of 8 mm diameter were made surgically in adult male Wistar rats. The animals were distributed equally into three groups: Biogran (GI), Perioglas (GII) and without implant material (control; GIII). The morphology and composition of both bioactive glasses were analyzed by scanning electron microscopy and energy-dispersive spectrometry. Tissue specimens were analyzed at the biological time points of 15, 30 and 60 days by optical microscopy and morphometry, demonstrating biocompatibility for the tested materials with moderate chronic inflammation involving their particles. Bone neoformation resulted only as a reparative reaction to an intentionally produced defect and was limited to the defect's edges. No statistically significant differences among the groups were observed. At the scar interstice, abundant deposits of collagenous fibers enveloping the particles were noted. The present results indicated that the bioactive glasses, under the experimental conditions analyzed, did not show osteogenic behavior.
authors.affiliation: Dentistry Faculty, Federal University of Bahia, Salvador, Brazil.
authors.forename: Ana Karina M V
authors.initials: AK
authors.lastname: Cardoso
authors.forename: Aryon de Almeida
authors.initials: Ade A
authors.lastname: Barbosa
authors.forename: Fúlvio Borges
authors.initials: FB
authors.lastname: Miguel
authors.forename: Elcio
authors.initials: E
authors.lastname: Marcantonio
authors.forename: Marcos
authors.initials: M
authors.lastname: Farina
authors.forename: Glória Dulce de Almeida
authors.initials: GD
authors.lastname: Soares
authors.forename: Fabiana Paim
authors.initials: FP
authors.lastname: Rosa
mesh_terms: D000818:Animals; D001843:Bone Cements; D018786:Bone Substitutes; D005898:Glass; D008297:Male; D019736:Prostheses and Implants; D051381:Rats; D017208:Rats, Wistar; D012886:Skull / Q000033:anatomy & histology* / Q000166:cytology; D013053:Spectrophotometry
chemical_list: C073544:Biogran; D001843:Bone Cements; D018786:Bone Substitutes