title: [Percutaneous intradiscal oxygen-ozone injection for lumbar disc herniation: no need of perioperative antibiotic prophylaxis].
abstract: OBJECTIVE
  To evaluate the feasibility of no antibiotic administration to prevent infection during the perioperative period of percutaneous intradiscal ozone-injection for treatment of lumbar disc herniation.
  
  
  METHODS
  Seventy-two patients with lumbar disc herniation but normal body temperature as well as normal results of three routine tests (blood, urine, stool) and C-reactive protein (CRP) level were randomly divided into two groups. The patients in prophylaxis group were given cephalothin V(2.0 g) intravenous 30 min before the operation, and the control group did not use any antibiotics. All the patients were injected with 6-10 ml ozone (40 microg/ml) for medical use into the discs with 21G needles under fluoroscopic guidance, followed by 10 ml ozone into the paravertebral space. Three days later the general examinations and CRP measurement were repeated.
  
  
  RESULTS
  No infection was found in these patients, nor were any significant differences noted in the results of the examinations between the two groups after controlling in patients with above-normal white blood cell count, neutrophil percentage and CRP level.
  
  
  CONCLUSIONS
  Prophylaxis antibiotics is not necessary during the perioperative period of percutaneous intradiscal ozone injection for lumbar disc herniation.
authors.affiliation: Department of Interventional Radiology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. wcjun1999 @163.com
authors.forename: Chuan-jun
authors.initials: CJ
authors.lastname: Wei
authors.forename: Yan-hao
authors.initials: YH
authors.lastname: Li
authors.forename: Yong
authors.initials: Y
authors.lastname: Chen
authors.forename: Jiang-yun
authors.initials: JY
authors.lastname: Wang
authors.forename: Qing-le
authors.initials: QL
authors.lastname: Zeng
authors.forename: Jian-bo
authors.initials: JB
authors.lastname: Zhao
authors.forename: Que-lin
authors.initials: QL
authors.lastname: Mei
mesh_terms: D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002437:Cefazolin / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D015552:Injections, Intralesional; D007405:Intervertebral Disc Displacement / Q000000981:diagnostic imaging / Q000188:drug therapy*; D008159:Lumbar Vertebrae; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000008:administration & dosage*; D010126:Ozone / Q000008:administration & dosage*; D019990:Perioperative Care; D011859:Radiography
chemical_list: D000900:Anti-Bacterial Agents; D010126:Ozone; D002437:Cefazolin; D010100:Oxygen