Aerosol and subcutaneous measles vaccine: measles antibody responses 6 years after re-vaccination.
There are no large-scale data on the long-term persistence of measles antibody after vaccination by the aerosol route. We therefore followed-up South African schoolchildren 6 years after their re-vaccination with Edmonston-Zagreb (EZ) and Schwarz (SW) measles vaccine given by aerosol and subcutaneous routes. Measles antibody levels and the proportion of children who were seropositive at year 6 remained significantly higher in the Edmonston-Zagreb aerosol group compared to the groups that received Schwarz or Edmonston-Zagreb vaccine subcutaneously. Measles re-vaccination by aerosol evokes a stronger and much longer lasting antibody response than injected vaccine and should thus provide more durable protection against measles.
Dilraj
Athmanundh
A
Unit for Clinical and Biomedical TB Research, Medical Research Council, 491 Ridge Road, Overport, Durban 4001, South Africa. dilraja@mrc.ac.za
Sukhoo
Reshma
R
Cutts
Felicity T
FT
Bennett
John V
JV
D000293:Adolescent; D000336:Aerosols; D000914:Antibodies, Viral / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007279:Injections, Subcutaneous; D008297:Male; D008457:Measles / Q000276:immunology / Q000517:prevention & control*; D008458:Measles Vaccine / Q000008:administration & dosage* / Q000276:immunology*; D008459:Measles virus / Q000276:immunology*; D013019:South Africa; D013997:Time Factors
D000336:Aerosols; D000914:Antibodies, Viral; D008458:Measles Vaccine