Outcome of acute liver failure due to acute hepatitis E in pregnant women.
BACKGROUND
Acute liver failure due to acute hepatitis E carries a high mortality.


METHODS
Clinical and laboratory parameters of 42 pregnant women (median age 25.5 years) with acute liver failure due to acute hepatitis E were retrospectively analyzed.


RESULTS
22 women delivered, whereas pregnancy continued in 20 women. The maternal mortality in these two groups was similar (9/22 [41%] versus 14/20 [70%], p=0.056). However, in patients with grade I, II or III hepatic encephalopathy, delivery of fetus was associated with reduced mortality in those who delivered as against those who continued pregnancy (5/16 (31%) vs. 13/20 (65%), p=0.046). On multivariate analysis, higher grade of encephalopathy at admission was associated with risk of death (p=0.005).


CONCLUSIONS
Mortality in pregnant women with acute liver failure with acute hepatitis E is high, especially in patients who present with higher grades of encephalopathy.
Banait
Vaibhav S
VS
Department of Gastroenterology, T N Medical College and BYL Nair Ch. Hospital, Mumbai 400 008, India.
Sandur
Virendra
V
Parikh
Falguni
F
Murugesh
M
M
Ranka
Purnima
P
Ramesh
V S
VS
Sasidharan
Madhu
M
Sattar
Abid
A
Kamat
Sandhya
S
Dalal
Asha
A
Bhatia
Shobna J
SJ
D000293:Adolescent; D016009:Chi-Square Distribution; D005260:Female; D016751:Hepatitis E / Q000401:mortality / Q000821:virology*; D006801:Humans; D007194:India / Q000453:epidemiology; D017114:Liver Failure, Acute / Q000401:mortality / Q000821:virology*; D008428:Maternal Mortality; D015999:Multivariate Analysis; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000401:mortality / Q000821:virology*; D011256:Pregnancy Outcome; D012189:Retrospective Studies; D012307:Risk Factors