title: Sporadic, severe bronchointerstitial pneumonia of foals.
abstract: Bronchointerstitial pneumonia was diagnosed postmortem in 19 foals in a 10 year retrospective study of submissions to a diagnostic center in Ontario. Mean age at death was 2.0 +/- 0.05 (SEM) mo (range five days to four months). Fourteen of 19 were aged from 1.5 to 2.5 mo. Clinically, the disease was generally characterized by sudden onset of fever and increasingly severe dyspnea which developed into respiratory distress before death. Mean length of illness was 7.0 +/- 0.33 days (range 1-21 days). The disease appeared to affect only individual foals on 19 different farms.At postmortem, lungs were typically diffusely red, wet, firm, and failed to collapse. The major lesion recognized histologically was epithelial necrosis of alveoli and terminal bronchioles. Alveolar lumens contained large epithelioid cells, which were probably macrophages, and multinucleated syncytial cells were present in 16 of the 19 lungs. Inflammatory cells were sparse. Intraalveolar fibrin was prominent in all lungs. Bacteriological examination revealed no significant pathogen in 12 animals, but Rhodococcus equi was isolated from seven foals, associated in two animals with extensive abscesses. Viruses were not recovered from eight foals examined.On the basis of the similarity and severity of lesions, the sporadic nature of the disease, and the similar age at onset which appears to coincide with declining maternally-derived immunoglobulins, we speculate that this disease may be the result of a viral infection.
authors.forename: J F
authors.initials: JF
authors.lastname: Prescott
authors.forename: B P
authors.initials: BP
authors.lastname: Wilcock
authors.forename: P S
authors.initials: PS
authors.lastname: Carman
authors.forename: A M
authors.initials: AM
authors.lastname: Hoffman