title: Colonic infiltration with chronic myelomonocytic leukemia.
abstract: BACKGROUND
  A 75-year-old female presented with a 1 month history of non-bloody diarrhea, associated with abdominal cramping and urgency. Her medical history was notable for chronic myelomonocytic leukemia, diagnosed 6 years previously and managed expectantly by monitoring the patient's complete blood count. Over several months, the patient's symptoms progressed, which resulted in significant weight loss. The patient's course of disease was ultimately complicated by acute disseminated encephalomyelitis and death.
  
  
  METHODS
  Physical examination, laboratory investigations, stool studies, colonoscopy with biopsies, immunohistochemistry and pathologic review of biopsy specimens.
  
  
  METHODS
  Leukemic colitis.
  
  
  RESULTS
  Management of underlying leukemia with systemic hydroxyurea and topical colonic 5-aminosalicylic acid therapy.
authors.affiliation: Section of Gastroenterology, Hepatology, and Nutrition, University of Chicago, Chicago, IL 60637, USA.
authors.forename: Andelka D
authors.initials: AD
authors.lastname: LoSavio
authors.forename: Alana P
authors.initials: AP
authors.lastname: Bunnag
authors.forename: David T
authors.initials: DT
authors.lastname: Rubin
mesh_terms: D015746:Abdominal Pain / Q000175:diagnosis / Q000209:etiology; D000368:Aged; D001707:Biopsy, Needle; D003092:Colitis / Q000209:etiology / Q000473:pathology / Q000628:therapy; D003106:Colon / Q000473:pathology*; D003113:Colonoscopy / Q000379:methods; D003967:Diarrhea / Q000175:diagnosis / Q000209:etiology; D018450:Disease Progression; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007413:Intestinal Mucosa / Q000473:pathology; D015477:Leukemia, Myelomonocytic, Chronic / Q000150:complications* / Q000188:drug therapy / Q000473:pathology*; D017254:Leukemic Infiltration / Q000175:diagnosis* / Q000628:therapy; D012720:Severity of Illness Index