title: Synthetic studies on macrolactin A: construction of C4-C24 fragment.
abstract: The preparation of the C4-C24 fragment of the macrolactin A is described. The adopted synthetic strategy involves two isomerizations to selectively construct the (8E,10Z) and (16E,18E) dienes, using a sequential Claisen rearrangement/allene isomerization and a Ph3P-catalyzed isomerization of an yne-one, respectively.
authors.affiliation: ICSN-CNRS Avenue de la Terrasse, 91198 Gif-sur-Yvette, France.
authors.forename: Marie
authors.initials: M
authors.lastname: Georgy
authors.forename: Philippe
authors.initials: P
authors.lastname: Lesot
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Campagne
mesh_terms: D002625:Chemistry, Organic / Q000379:methods*; D007536:Isomerism; D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure
chemical_list: D018942:Macrolides; C453562:macrolactin A