title: Noninvasive ventilation with positive airway pressure in paediatric intensive care.
abstract: OBJECTIVE
  The aim of the present study is to retrospectively evaluate the effectiveness of noninvasive pressure ventilation in the 24-bed Pediatric Intensive Care Unit (PICU) of the G. Gaslini Institute during a 24-month period.
  
  
  METHODS
  A retrospective analysis of the characteristics (pH, CO2, SpO2, respiratory rate, oxygen requirement) of patients treated with noninvasive mechanical ventilation for different acute pathologies has been performed.
  
  
  RESULTS
  Twenty patients (mean age 7.4+/-0.28 years) with acute respiratory failure due to different pathologies were treated with noninvasive mechanical ventilation. They were divided into 2 groups: the hypoxic group, suffering from pulmonary diseases, and the hypercapnic group, presenting a failure of the mechanical strength or increased dead space. Modalities of ventilation were pressure assisted/controlled or pressure support, delivered through nasal or facial masks. Fifteen out of 20 patients presented a marked improvement of oxygenation and ventilation. Mean times of treatment were 69 and 200 h in the hypoxic and hypercapnic groups, respectively. Five patients required intubation. Two patients presented reversible skin lesions over the nasal bridge.
  
  
  CONCLUSIONS
  Noninvasive ventilation can be used in PICU. Major advantages regard immunocompromised children and patients with exacerbations from chronic respiratory diseases, whereas the exact role of noninvasive positive pressure ventilation in patients affected by acute respiratory distress syndrome is still controversial.
authors.affiliation: Unit of Anesthesia and Intensive Care, G. Gaslini IRCCS, Genoa, Italy. giancarloottonello@ospedale-gaslini.ge.it
authors.forename: G
authors.initials: G
authors.lastname: Ottonello
authors.forename: G
authors.initials: G
authors.lastname: Villa
authors.forename: L
authors.initials: L
authors.lastname: Doglio
authors.forename: M
authors.initials: M
authors.lastname: Pedemonte
authors.forename: M C
authors.initials: MC
authors.lastname: Diana
authors.forename: R
authors.initials: R
authors.lastname: Casciaro
authors.forename: A
authors.initials: A
authors.lastname: De Alessandri
authors.forename: G
authors.initials: G
authors.lastname: Silvestri
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003422:Critical Care / Q000379:methods*; D005260:Female; D006801:Humans; D007223:Infant; D015278:Intensive Care Units, Pediatric; D008297:Male; D011175:Positive-Pressure Respiration / Q000379:methods*; D012189:Retrospective Studies