Reactive oxygen species regulate autophagy through redox-sensitive proteases.
Starvation induces autophagy through a signal transduction pathway that is not fully understood. In a recent issue of The EMBO Journal, Scherz-Shouval and colleagues (Scherz-Shouval et al., 2007) show that reactive oxygen species (ROS) occurring during starvation serve as signaling molecules that initiate autophagy.
Liu
Zhihua
Z
Laboratory of Immunology, NIAID, NIH, Building 10, Room 11N311, 10 Center Drive, MSC 1892, Bethesda, MD 20892, USA. liuzhi@niaid.nih.gov
Lenardo
Michael J
MJ
D000818:Animals; D001343:Autophagy; D015971:Gene Expression Regulation, Enzymologic; D006801:Humans; D008954:Models, Biological; D010084:Oxidation-Reduction; D010447:Peptide Hydrolases / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism*; D015398:Signal Transduction
D017382:Reactive Oxygen Species; D010447:Peptide Hydrolases