Geroprotective effect of epithalamine (pineal gland peptide preparation) in elderly subjects with accelerated aging.
A 12-year randomized clinical study of epithalamine (pineal gland peptide preparation) was carried out in elderly patients with coronary disease and accelerated aging of the cardiovascular system. Long-term treatment with epithalamine decreased the functional age and degree of cardiovascular aging; exercise tolerance increased. After 12 years the number of elderly subjects dead in the group treated by epithalamine was 28% lower than in the control group, despite the same basic therapy. Cardiovascular mortality was 2-fold lower in patients treated by epithalamine; the incidence of cardiovascular failure and respiratory diseases was 2-fold lower in this group. Long-term treatment with epithalamine was associated with a geroprotective effect on the long-term life prognosis in elderly subjects with accelerated aging.
Korkushko
O V
OV
Institute of Gerontology, Academy of Medical Sciences of Ukraine, Kiev.
Khavinson
V Kh
VKh
Shatilo
V B
VB
Antonyuk-Shcheglova
I A
IA
D000368:Aged; D003327:Coronary Disease / Q000150:complications* / Q000453:epidemiology / Q000401:mortality; D017079:Exercise Tolerance / Q000187:drug effects; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008136:Longevity / Q000187:drug effects*; D008875:Middle Aged; D010455:Peptides / Q000009:adverse effects / Q000737:chemistry / Q000494:pharmacology*; D010870:Pineal Gland / Q000737:chemistry*; D012140:Respiratory Tract Diseases / Q000453:epidemiology / Q000401:mortality; D013997:Time Factors; D016896:Treatment Outcome
D010455:Peptides; C027437:epithalamin