[Study on the di-n-butyl phthalate and di-2-ethylhexyl phthalate level of girl serum related with precocious puberty in Shanghai].
OBJECTIVE
To determine the levels of the di-n-butyl phthalate and di-2-ethylhexyl phthalate in the serum of precocious girls in Shanghai, and study the development relationship between DBP, DEHP and precocious girls.


METHODS
The concentrations of two phthalates (di-n-butyl phthalate, DBP, di-2-ethylhexyl phthalate, DEHP) in serum of 110 precocious girls and 100 normal children were measured by using gas chromatography, in the same time, the volumes of the uteruses and ovaries for precocious girls and normal children were measured by B-ultrasound and then did correlation analysis between the concentrations of DBP, DEHP and the volumes of uteruses and ovaries of precocious girls.


RESULTS
DBP and DEHP were detected for 27.3% and 22.7% in precocious girls respectively, DBP and DEHP were detected for only 4% and 3% in normal children respectively. From the ratio of DBP and DEHP in serum of precocious girls were higher than normal children. Precocious girls uteruses and ovaries volume were higher than those of normal children respectively (P < 0.05, P < 0.05). DBP in serum of precocious girls had positive correlation with the volumes of the uteruses (r = 0.456, P < 0.05), and had positive correlation with volumes of the ovaries (r = 0.378, P < 0.01). DEHP in serum of precocious puberty had positive correlation with the volumes of uteruses (r = 0.382, P < 0.05), and had positive correlation with volumes of ovaries (r = 0.689, P < 0.01).


CONCLUSIONS
Precocious girls could be contaminated more severely than normal girls, and DBP, DEHP could influence the volumes of the uteruses and ovaries.
Qiao
Lili
L
Department of Children Hospital, Fudan University, Shanghai 200032, China.
Zheng
Lixing
L
Cai
Depei
D
D016022:Case-Control Studies; D002648:Child; D002681:China; D002849:Chromatography, Gas; D003993:Dibutyl Phthalate / Q000097:blood*; D004051:Diethylhexyl Phthalate / Q000097:blood*; D052244:Endocrine Disruptors / Q000097:blood*; D005260:Female; D006801:Humans; D011629:Puberty, Precocious / Q000097:blood*
D052244:Endocrine Disruptors; D003993:Dibutyl Phthalate; D004051:Diethylhexyl Phthalate