title: More is not always better: the genetic constraints of polyploidy.
abstract: Polyploid cells are a characteristic feature of certain human tissues, and notably many cancers. In a systematic genomic screen in yeast, Storchová and co-workers identified the genetic requirements of tetraploidy. Surprisingly, they showed that only three connected pathways are essential for the viability of tetraploid yeast cells. These data provide exciting new targets that might be essential specifically in polyploid cancer cells.
authors.affiliation: Department of Genetics & Development, Columbia University Medical Center, 701 West 168th Street, New York, NY 10032-2704, USA.
authors.forename: Peter H
authors.initials: PH
authors.lastname: Thorpe
authors.forename: Sergio
authors.initials: S
authors.lastname: González-Barrera
authors.forename: Rodney
authors.initials: R
authors.lastname: Rothstein
mesh_terms: D000818:Animals; D005800:Genes, Fungal / Q000502:physiology; D042822:Genomic Instability / Q000235:genetics*; D006801:Humans; D011123:Polyploidy; D012441:Saccharomyces cerevisiae / Q000235:genetics*