title: Microbial transformation of the steroidal alkaloid dictyophlebine by Rhizopus stolonifer.
abstract: The microbial transformation of a steroidal alkaloid, dictyophlebine (1) with Rhizopus stolonifer (ATCC 10404) afforded three oxidized metabolites 2-4. Compound 2 was found to be a new product. These metabolites were structurally characterized on the basis of modern spectroscopic techniques. Their inhibitory activity towards acetyl- and butyrylcholinesterase has been evaluated and the new product 2 has been found to be more potent than the parent compound and other metabolites.
authors.affiliation: Institute of Forestry, Tribhuvan University, Kaski, Nepal. devkotakpd@yahoo.com
authors.forename: Krishna Prasad
authors.initials: KP
authors.lastname: Devkota
authors.forename: Muhammad Iqbal
authors.initials: MI
authors.lastname: Choudhary
authors.forename: Sarfaraz Ahmed
authors.initials: SA
authors.lastname: Nawaz
authors.forename: Alain Meli
authors.initials: AM
authors.lastname: Lannang
authors.forename: Bruno Ndjakou
authors.initials: BN
authors.lastname: Lenta
authors.forename: Patrice Aime
authors.initials: PA
authors.lastname: Fokou
authors.forename: Norbert
authors.initials: N
authors.lastname: Sewald
mesh_terms: D001711:Biotransformation; D009682:Magnetic Resonance Spectroscopy; D012233:Rhizopus / Q000378:metabolism*; D021241:Spectrometry, Mass, Electrospray Ionization; D013056:Spectrophotometry, Ultraviolet; D013256:Steroids / Q000737:chemistry / Q000378:metabolism*
chemical_list: D013256:Steroids; C520060:dictyophlebine