title: Association analysis between the C516T polymorphism in the 5-HT2A receptor gene and schizophrenia.
abstract: Data from epidemiological studies have demonstrated that genetics is an important risk factor for schizophrenia. Disturbances of serotonergic brain pathways have been implicated in the pathophysiology of schizophrenia. Some studies have suggested that the efficacy of atypical antipsychotics on schizophrenia treatment may be related to the serotonin 2A receptor (5-HT2A), and that serotonergic drugs may induce psychotic symptoms. Thus, the aim of this study was to investigate the association between the C516T polymorphism and schizophrenia in a Brazilian population composed by 246 patients and 315 healthy matched controls in a case-control approach. No statistically differences were observed in allelic (chi2=1.77, 1d.f., p=0.18) or genotypic (chi2=1.69, 2d.f., p=0.42) distributions between cases and controls. The results suggest that the C516T polymorphism of the 5-HT2A receptor gene is not related to the susceptibility for schizophrenia in our Brazilian sample.
authors.affiliation: Department and Institute of Psychiatry, Medical School, University of São Paulo, São Paulo, SP, Brazil.
authors.forename: Vivian
authors.initials: V
authors.lastname: Bertola
authors.forename: Quirino
authors.initials: Q
authors.lastname: Cordeiro
authors.forename: Stevin
authors.initials: S
authors.lastname: Zung
authors.forename: Elisabete Cristina
authors.initials: EC
authors.lastname: Miracca
authors.forename: Homero
authors.initials: H
authors.lastname: Vallada
mesh_terms: D000483:Alleles; D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D011110:Polymorphism, Genetic / Q000235:genetics*; D044402:Receptor, Serotonin, 5-HT2A / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*
chemical_list: D044402:Receptor, Serotonin, 5-HT2A