title: [Williams-Beuren syndrome].
abstract: Williams-Beuren syndrome (MIM 194050) is a rare genetic disease (incidence: 1/20 000) which is rather easy to identify during childhood. This developmental disorder associates cardiac defect (supra valvular aortic stenosis most often) in 75% of cases, suggestive face dysmorphism and specific cognitive and behavioural profile. Cognitive profile consists of visuo-spatial bearing deficits contrasting with a relatively well-preserved language. Affected children present with a hyper social behaviour, especially toward strangers; they have a distinctive sensitivity to noise and music. Arterial tension and renal functions have to be looked after during the whole life. Medical and educative management must be done on a multidisciplinary way combining pediatric, cardio-pediatric, orthodontic and psychological approach. Adult patients are generally not completely self-sufficient. Williams-Beuren syndrome is due to a chromosomal microdeletion in the q11.23 region of one chromosome 7. It can not be seen on a conventional karyotype and is detected by a FISH (fluorescent in situ hybridization) analyse. This microdeletion leads to the suppression of many genes, mainly the elastin gene.
authors.affiliation: Service de génétique médicale , CHU La Milétrie, 86021 Poitiers Cedex. b.gilbert@chu-poitiers.fr
authors.forename: Brigitte
authors.initials: B
authors.lastname: Gilbert-Dussardier
mesh_terms: D000328:Adult; D002648:Child; D002897:Chromosomes, Human, Pair 7 / Q000235:genetics; D004452:Echocardiography; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D018980:Williams Syndrome / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000235:genetics / Q000628:therapy