Production of lymphocyte-activating factors by mouse macrophages during aging and under the effect of short peptides.
Age-specific characteristics of production of lymphocyte-activating factor by mouse peritoneal macrophages and modulation of this production by short synthetic peptides (Vilon, Epithalon, and Cortagen) were studied. The production of lymphocyte-activating factors by macrophages stimulated with lipopolysaccharides in vitro was lower in old animals. The opposite modulating effects of short peptides on the production of lymphocyte-activating factors by resident and lipopolysaccharide-stimulated macrophages in young and old mice were demonstrated for the first time. This is a possible mechanism of immune system dysfunction during aging, which opens new vistas for its correction with short synthetic peptides.
Gumen
A V
AV
Laboratory of Peptide Pharmacology, St. Petersburg Institute of Bioregulation and Gerontology, North-Western Division of Russian Academy of Medical Sciences.
Kozinets
I A
IA
Shanin
S N
SN
Malinin
V V
VV
Rybakina
E G
EG
D000375:Aging / Q000502:physiology*; D000818:Animals; D003433:Crosses, Genetic; D004305:Dose-Response Relationship, Drug; D007375:Interleukin-1 / Q000096:biosynthesis*; D008070:Lipopolysaccharides / Q000633:toxicity; D008262:Macrophage Activation / Q000187:drug effects; D017737:Macrophages, Peritoneal / Q000187:drug effects* / Q000378:metabolism*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009842:Oligopeptides / Q000494:pharmacology; D010455:Peptides / Q000737:chemistry / Q000494:pharmacology*
D007375:Interleukin-1; D008070:Lipopolysaccharides; D009842:Oligopeptides; D010455:Peptides