Mechanisms of cardiac potassium channel trafficking.
The regulation of ion channels involves more than just modulation of their synthesis and kinetics, as controls on their trafficking and localization are also important. Although the body of knowledge is fairly large, the entire trafficking pathway is not known for any one channel. This review summarizes current knowledge on the trafficking of potassium channels that are expressed in the heart. Our knowledge of channel assembly, trafficking through the Golgi apparatus and on to the surface is covered, as are controls on channel surface retention and endocytosis.
Steele
David F
DF
Department of Physiology, University of British Columbia, 2146 Health Sciences Mall, Vancouver, British Columbia, Canada V6T 1Z3.
Eldstrom
Jodene
J
Fedida
David
D
D000818:Animals; D003598:Cytoskeletal Proteins / Q000378:metabolism; D004705:Endocytosis; D004721:Endoplasmic Reticulum / Q000378:metabolism; D006056:Golgi Apparatus / Q000378:metabolism*; D051528:Guanylate Kinases / Q000378:metabolism; D006801:Humans; D008958:Models, Molecular; D018832:Molecular Chaperones / Q000378:metabolism; D009206:Myocardium / Q000201:enzymology / Q000378:metabolism*; D015221:Potassium Channels / Q000737:chemistry / Q000378:metabolism*; D011487:Protein Conformation; D021381:Protein Transport; D012508:Sarcolemma / Q000201:enzymology / Q000378:metabolism*
D003598:Cytoskeletal Proteins; D018832:Molecular Chaperones; D015221:Potassium Channels; D051528:Guanylate Kinases