[Antiarrhythmic activity of lidocaine under conditions of lipid and carbohydrate metabolisms disturbances in modeling early occlusional and reperfusional arrhythmias].
The antiarrhythmic activity of lidocaine on the models of early arrhythmias induced by occlusion and reperfusion was studied in rats with background derangements of lipidic and carbohydrate metabolisms. It was established that lidocaine in a dose of 100 mg/kg did not produce reliable antiarrhythmic action under these conditions. In addition, changes in the development of early occlusional and reperfusional arrhythmias against the background violation of lipid and carbohydrate metabolisms were found.
Artem'eva
O V
OV
Koriaĭ kina
A V
AV
Zor'kina
A V
AV
D000496:Alloxan / Q000633:toxicity; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D001145:Arrhythmias, Cardiac / Q000150:complications / Q000188:drug therapy*; D050260:Carbohydrate Metabolism; D004195:Disease Models, Animal; D050171:Dyslipidemias / Q000139:chemically induced / Q000150:complications*; D006943:Hyperglycemia / Q000139:chemically induced / Q000150:complications*; D008012:Lidocaine / Q000627:therapeutic use*; D050356:Lipid Metabolism; D015425:Myocardial Reperfusion; D051381:Rats; D011919:Rats, Inbred Strains
D000889:Anti-Arrhythmia Agents; D000496:Alloxan; D008012:Lidocaine