title: [Study of a role of artificial mycobacterial particles in the realization of immunological processes in experimental animal tuberculosis].
abstract: The protective properties of artificial mycobacterial particles versus BCG vaccine were studied in laboratory animals with experimental tuberculosis. The findings of the decreased rate of a tuberculous process and on the increased mean life span in animals inoculated with M. bovis suggest that immunization of guinea-pigs with mycobacterial particles promotes the enhanced development of antituberculous immunity in the animals. The paper proposes a promising method for designing artificial immunogens, the high-polymer antigenic structures that imitates mycobacterial particles.
authors.forename: M Sh
authors.initials: MSh
authors.lastname: Azaev
authors.forename: L R
authors.initials: LR
authors.lastname: Lebedev
authors.forename: G A
authors.initials: GA
authors.lastname: Kuz'micheva
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Tumanov
authors.forename: N A
authors.initials: NA
authors.lastname: Donchenko
authors.forename: S I
authors.initials: SI
authors.lastname: Tat'kov
authors.forename: O V
authors.initials: OV
authors.lastname: Nosareva
authors.forename: A A
authors.initials: AA
authors.lastname: Il'ichev
mesh_terms: D000818:Animals; D001500:BCG Vaccine / Q000276:immunology*; D003627:Data Interpretation, Statistical; D004195:Disease Models, Animal; D006168:Guinea Pigs; D007114:Immunization; D007124:Immunoenzyme Techniques; D009163:Mycobacterium bovis / Q000276:immunology*; D010587:Phagocytosis; D014376:Tuberculosis / Q000276:immunology / Q000517:prevention & control*; D032581:Tuberculosis Vaccines / Q000276:immunology*; D014614:Vaccines, Synthetic / Q000276:immunology*
chemical_list: D001500:BCG Vaccine; D032581:Tuberculosis Vaccines; D014614:Vaccines, Synthetic