Electrochemical determination of meloxicam in pharmaceutical preparation and biological fluids using oxidized glassy carbon electrodes.
The adsorptive and electrochemical behaviors of meloxicam (MLC) was investigated on a glassy carbon electrode that was electrochemically treated by anodic oxidation at +1.8 V, following potential cycling in the potential range from -0.8 to 1.0 V vs. Ag/AgCl reference electrode. The resulting electrode showed a good activity to improve the electrochemical response of the drug. MLC was accumulated at an electrochemically activated glassy carbon electrode (phosphate buffer pH 6) in a certain time and then determined by linear sweep voltammetry. The oxidative peak currents showed a linear function in the concentration ranges of 0.02 to 10 microM using a 240 s preconcentration time. The preconcentration medium-exchange approach was utilized for the selective determination of the drug in spiked urine and plasma samples with satisfactory results. The recovery values of the proposed method obtained 105% (RSD 2.5%) and 100% (RSD 1.8%) for urine and plasma samples, respectively. Also, the proposed method has been successfully used for determination of MLC in tablets.
Farhadi
Khalil
K
Department of Chemistry, Faculty of Science, Urmia University, Iran. kh.farhadi@mail.urmi.ac.ir
Karimpour
Ahmad
A
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000032:analysis*; D001826:Body Fluids / Q000737:chemistry*; D002244:Carbon; D004563:Electrochemistry / Q000379:methods*; D004566:Electrodes; D000077239:Meloxicam; D010084:Oxidation-Reduction; D013843:Thiazines / Q000032:analysis*; D013844:Thiazoles / Q000032:analysis*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D013843:Thiazines; D013844:Thiazoles; D002244:Carbon; D000077239:Meloxicam