Effect of rapid slight cooling of the skin in various phases of immunogenesis on the immune response.
Slight cooling had no effect on heat emission and heat production, but modulated the immune response to antigen in animals. Changes in the immune response upon rapid slight cooling of the skin (by 1.5 degrees C) depended on the phase of immunogenesis corresponding to cold exposure. When cooling was performed immediately after immunization, antibody production increased in the spleen and blood, while antigen binding in the spleen remained unchanged. Cold exposure on day 5 after antigen treatment as well as immunization at the peak of cooling did not modulate antibody production, but increased antigen binding in the spleen. Our findings attest to an important role of the temperature factor in the formation of the immune response, which should be taken into account during vaccination.
Kozyreva
T V
TV
Laboratory of Thermophysiology, Institute of Physiology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk. kozyreva@iph.ma.nsc.ru
Eliseeva
L S
LS
Tsoi
L V
LV
Khramova
G M
GM
D000818:Animals; D003080:Cold Temperature; D004912:Erythrocytes / Q000276:immunology; D007114:Immunization; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012756:Sheep / Q000276:immunology; D012867:Skin / Q000276:immunology*; D012881:Skin Temperature / Q000502:physiology*