title: Neck dissection for squamous cell carcinoma of the head and neck.
abstract: OBJECTIVE
  To investigate the successes and failures of 172 patients receiving neck dissections for squamous cell carcinoma (SCC) managed through a multidisciplinary head and neck clinic and to observe factors in predicting failure (death with head and neck cancer or local regional recurrence) or local regional recurrence alone.
  
  
  METHODS
  A retrospective, 14-year surgical audit.
  
  
  METHODS
  The information from patient medical records was correlated with that of a database. Multivariate analysis was performed with the use of a logistic regression model.
  
  
  RESULTS
  The most common site for head and neck SCC was the oral cavity (42%), with 17% of patients having tumors of unknown primary site. The disease-free survival probability was 76.7% at five years. Patients who were older at neck dissection, were nonsmokers, or who did not have radiotherapy to the primary site were more likely to die with head and neck cancer or to have local regional recurrence (P < 0.1). Patients with more radical neck dissections did not have better survival or recurrence outcomes. Lymphatic invasion appears to be the only important factor in predicting local regional recurrence alone (P = 0.1), of which 67% occurred within the first postoperative year.
  
  
  CONCLUSIONS
  Patients with smoking-related SCC are likely to have a less aggressive disease. Adjuvant radiotherapy plays an important role in the treatment of patients with head and neck SCC. Follow-up, especially within the first postoperative year, is essential in managing head and neck SCC. Head and neck surgeons can confidently continue their practice away from more radical neck dissections.
authors.affiliation: Department of Ear, Nose, and Throat Surgery, Fremantle Hospital, Perth, Western Australia, Australia. petersantamaria@hotmail.com
authors.forename: Peter L
authors.initials: PL
authors.lastname: Santa Maria
authors.forename: Chady
authors.initials: C
authors.lastname: Sader
authors.forename: Neil J M
authors.initials: NJ
authors.lastname: Preston
authors.forename: Philip H
authors.initials: PH
authors.lastname: Fisher
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000209:etiology / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006258:Head and Neck Neoplasms / Q000209:etiology / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*; D006801:Humans; D016015:Logistic Models; D008297:Male; D008499:Medical Records; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000601:surgery; D015999:Multivariate Analysis; D037981:Neck Dissection; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*; D009367:Neoplasm Staging; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies; D012907:Smoking / Q000009:adverse effects; D016896:Treatment Outcome