Melphalan in ultralow doses decreases the severity of experimental colitis in mice.
We studied the effect of melphalan in ultralow doses on mice with experimental colitis induced by substitution of drinking water for 5% dextran sulfate. Daily treatment with melphalan in a dose of 0.025 mg/kg improved the general state of animals. The influence of melphalan was evaluated by quantitative clinical, pathomorphological, and laboratory parameters. Melphalan had a local and systemic antiinflammatory effect.
Pukhalskii
A L
AL
Medical and Genetic Research Center, Russian Academy of Medical Sciences, Moscow. osugariver@ med_gen.ru
Shmarina
G V
GV
Aleshkin
V A
VA
D000818:Animals; D003092:Colitis / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D016264:Dextran Sulfate; D004305:Dose-Response Relationship, Drug; D007413:Intestinal Mucosa / Q000187:drug effects / Q000473:pathology; D007420:Intestine, Large / Q000187:drug effects / Q000473:pathology; D008297:Male; D008558:Melphalan / Q000627:therapeutic use*; D051379:Mice; D008807:Mice, Inbred BALB C
D016264:Dextran Sulfate; D008558:Melphalan