title: Effects of engrafted neural stem cells derived from GFP transgenic mice in Parkinson's diseases rats.
abstract: This study evaluated the therapeutic effect of neural stem cells (NSCs) transplanted into Parkinson's disease (PD) rats. NSCs were identified in vitro, then engrafted into the striatum of the PD rats. The rotational behavior was evaluated 1, 2, 4 and 6 weeks. A significant rotational behavior improvement was observed in PD rats subjected to cell transplantation. Transplanted NSCs not only express Nerve growth factor and Neurotrophin-3 in vitro, but also survive and partly differentiate into tyrosine hydroxylase (TH) positive cells in vivo. The results show that NSCs could be effective for PD treatment and the mechanisms might involve the neurotrophin expression and the neural differentiation.
authors.affiliation: Renmin Western Road No. 191, Institute of Neuroscience, Kunming Medical College, 650031, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Wei
authors.forename: Jia
authors.initials: J
authors.lastname: Liu
authors.forename: Hao-Li
authors.initials: HL
authors.lastname: Zhou
authors.forename: Zhi-Tong
authors.initials: ZT
authors.lastname: Han
authors.forename: Qing-Ying
authors.initials: QY
authors.lastname: Wu
authors.forename: Jiang-Xia
authors.initials: JX
authors.lastname: Pang
authors.forename: Su
authors.initials: S
authors.lastname: Liu
authors.forename: Ting-Hua
authors.initials: TH
authors.lastname: Wang
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D000978:Antiparkinson Agents / Q000494:pharmacology; D001058:Apomorphine / Q000494:pharmacology; D001522:Behavior, Animal; D004195:Disease Models, Animal; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D049452:Green Fluorescent Proteins / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D008822:Mice, Transgenic; D009474:Neurons / Q000502:physiology*; D016627:Oxidopamine / Q000633:toxicity; D010300:Parkinson Disease / Q000188:drug therapy / Q000209:etiology / Q000601:surgery*; D051381:Rats; D017207:Rats, Sprague-Dawley; D033581:Stem Cell Transplantation / Q000379:methods*; D013234:Stem Cells / Q000502:physiology*; D013239:Stereotyped Behavior / Q000187:drug effects; D013565:Sympatholytics / Q000633:toxicity; D013997:Time Factors; D014183:Transplantation, Heterologous; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
chemical_list: D000978:Antiparkinson Agents; D005904:Glial Fibrillary Acidic Protein; D013565:Sympatholytics; D049452:Green Fluorescent Proteins; D016627:Oxidopamine; D014446:Tyrosine 3-Monooxygenase; D001058:Apomorphine