title: Angioimmunoblastic T-cell lymphoma initially presenting with replacement of bone marrow and peripheral plasmacytosis.
abstract: A 73-year-old man presented with lymphadenopathy, hepatosplenomegaly, and a variety of hematological and immunological abnormalities. The bone marrow was replaced by polymorphic cellular infiltrates containing aggregates of CD10(+) T-cells. Circulating lymphoplasmacytic/immunoblastic cells showed an early plasma cell immunophenotype on flow cytometric analysis. Combination of these observations indicated that the underlying disorder of this patient was angioimmunoblastic T-cell lymphoma (AITL); postmortem pathology was consistent with progression of peripheral T-cell lymphoma. Even in the absence of definitive lymph node biopsy, the appearance of the bone marrow and the peripheral blood can lead to the diagnosis of AITL.
authors.affiliation: Department of Internal Medicine, Takeda General Hospital, Kyoto, Japan.
authors.forename: Hisashi
authors.initials: H
authors.lastname: Sakai
authors.forename: Hideaki
authors.initials: H
authors.lastname: Tanaka
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Katsurada
authors.forename: Yataro
authors.initials: Y
authors.lastname: Yoshida
authors.forename: Eiichi
authors.initials: E
authors.lastname: Okamoto
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Ohno
mesh_terms: D000368:Aged; D001344:Autopsy; D001707:Biopsy, Needle; D001853:Bone Marrow / Q000473:pathology*; D003937:Diagnosis, Differential; D018450:Disease Progression; D017809:Fatal Outcome; D006801:Humans; D007119:Immunoblastic Lymphadenopathy / Q000175:diagnosis / Q000473:pathology*; D007150:Immunohistochemistry; D016411:Lymphoma, T-Cell, Peripheral / Q000175:diagnosis / Q000473:pathology*; D008297:Male; D010950:Plasma Cells / Q000473:pathology*; D018570:Risk Assessment; D012720:Severity of Illness Index