Korean ginseng induces spermatogenesis in rats through the activation of cAMP-responsive element modulator (CREM).
The effect of Korean ginseng (ginseng) on spermatogenesis and cAMP-responsive element modulator (CREM) in rat testes was evaluated using sperm analysis, reverse transcription polymerase chain reaction, and Western blot analysis. The ginseng-treated rats exhibited significantly increased sperm count and motility with enhanced levels of CREM messenger RNA and protein. Ginseng appears to induce spermatogenesis via CREM activation in rat testes.
Park
Wan Su
WS
Department of Pathology, College of Oriental Medicine, Kyungwon University, Seongnam, Korea.
Shin
Dong Youp
DY
Kim
Do Rim
DR
Yang
Woong Mo
WM
Chang
Mun Seog
MS
Park
Seong Kyu
SK
D000818:Animals; D051786:Cyclic AMP Response Element Modulator / Q000378:metabolism*; D008297:Male; D005894:Panax; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013076:Sperm Count; D013081:Sperm Motility / Q000187:drug effects; D013091:Spermatogenesis / Q000187:drug effects*
C497412:Crem protein, rat; D010936:Plant Extracts; D051786:Cyclic AMP Response Element Modulator