Novel lbeta-methylcarbapenems having cyclic sulfonamide moieties: synthesis and evaluation of in vitro antibacterial activity.
The synthesis of a new series of 1beta-methylcarbapenems having cyclic sulfonamide moieties is described. Their in vitro antibacterial activities against both Gram-positive and Gram-negative bacteria were tested and the effect of substituent on the pyrrolidine ring was investigated. A particular compound (IIIi) having 2-methyl-[1,2,6]thiadiazinan-1,1-dioxide moiety showed the most potent antibacterial activity.
Kim
Seong Jong
SJ
Medicinal Chemistry Research Center, Korea Institute of Science and Technology, Seoul 130-650, South Korea.
Park
Hyeong Beom
HB
Lee
Jae Seoung
JS
Jo
Nam Hyun
NH
Yoo
Kyung Ho
KH
Baek
Daejin
D
Kang
Byoung-Won
BW
Cho
Jung-Hyuck
JH
Oh
Chang-Hyun
CH
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015780:Carbapenems / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared
D000900:Anti-Bacterial Agents; D015780:Carbapenems