Two indolocarbazole alkaloids with apoptosis activity from a marine-derived actinomycete Z(2)039-2.
Bioassay-guided fractionation of the EtOAc extract from the fermentation broth of a marine-derived actinomycete Z(2)039-2 led to the isolation of two known indolocarbazole alkaloids, K252c (1) and arcyriaflavin A (2). 1 and 2 exhibited moderate cytotoxic activities against the K562 cell line, and induced apoptotic activities at 10 and 100 microM, respectively. This is the first report on the significant apoptosis inducing effect of indolocarbazole alkaloids against K562 cancer cells.
Liu
Rui
R
Key laboratory of Marine Drugs, Chinese Ministry of Education, Qingdao 266003, PR China.
Zhu
Tianjiao
T
Li
Dehai
D
Gu
Jingyan
J
Xia
Wei
W
Fang
Yuchun
Y
HongbingLiu
Zhu
Weiming
W
Gu
Qianqun
Q
D039903:Actinobacteria / Q000378:metabolism*; D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects*; D002227:Carbazoles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D007211:Indoles / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D020014:K562 Cells; D009682:Magnetic Resonance Spectroscopy; D014871:Water Microbiology
D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D002227:Carbazoles; D007211:Indoles