Clopidogrel (Plavix) reduces the rate of thrombosis in the rat tuck model for microvenous anastomosis.
OBJECTIVE
To evaluate the effect of clopidogrel on the rate of thrombosis in a rat model for venous microvascular failure.


METHODS
Forty rats were treated with clopidogrel or saline control via gastric gavage in a randomized, blinded fashion. After allowing for absorption and activation, each femoral vein was isolated and a venous "tuck" procedure was performed. The bleeding time and vessel patency were subsequently evaluated.


RESULTS
The rate of vessel thrombosis was decreased in the clopidogrel-treated group compared to controls (7.9% vs 31.4%, P < 0.025). The bleeding time was longer in the clopidogrel-treated group compared to controls (250 +/- 100 seconds vs 173 +/- 59 seconds, P < 0.015).


CONCLUSIONS
Clopidogrel decreased the rate of thrombosis in the rat model for venous microvascular failure.


CONCLUSIONS
The use of clopidogrel may reduce the rate of venous thrombosis after free tissue transfer and may be indicated in select patients.
Moore
Michael G
MG
Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA. michael_moore@meei.harvard.edu
Deschler
Daniel G
DG
D000714:Anastomosis, Surgical / Q000009:adverse effects; D000818:Animals; D000077144:Clopidogrel; D008297:Male; D008866:Microsurgery; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013536:Suture Techniques; D013927:Thrombosis / Q000209:etiology* / Q000517:prevention & control*; D013988:Ticlopidine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D014656:Vascular Surgical Procedures / Q000009:adverse effects*; D014680:Veins / Q000601:surgery*
D010975:Platelet Aggregation Inhibitors; D000077144:Clopidogrel; D013988:Ticlopidine