Polyspecificity of T cell and B cell receptor recognition.
A recent workshop discussed the recognition of multiple distinct ligands by individual T cell and B cell receptors and the implications of this discovery for lymphocyte biology. The workshop recommends general use of the term polyspecificity because it emphasizes two fundamental aspects, the inherent specificity of receptor recognition and the ability to recognize multiple ligands. Many different examples of polyspecificity and the structural mechanisms were discussed, and the group concluded that polyspecificity is a general, inherent feature of TCR and antibody recognition. This review summarizes the relevance of polyspecificity for lymphocyte development, activation and disease processes.
Wucherpfennig
Kai W
KW
Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA. kai_wucherpfennig@dfci.harvard.edu
Allen
Paul M
PM
Celada
Franco
F
Cohen
Irun R
IR
De Boer
Rob
R
Garcia
K Christopher
KC
Goldstein
Byron
B
Greenspan
Ralph
R
Hafler
David
D
Hodgkin
Philip
P
Huseby
Erik S
ES
Krakauer
David C
DC
Nemazee
David
D
Perelson
Alan S
AS
Pinilla
Clemencia
C
Strong
Roland K
RK
Sercarz
Eli E
EE
D000818:Animals; D017951:Antigen Presentation / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D006801:Humans; D008024:Ligands; D008213:Lymphocyte Activation / Q000276:immunology*; D051379:Mice; D010455:Peptides / Q000276:immunology; D011948:Receptors, Antigen, T-Cell / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
D008024:Ligands; D010455:Peptides; D011948:Receptors, Antigen, T-Cell