Neurotrophin-3, TNF-alpha and IL-6 relations in serum and cerebrospinal fluid of ischemic stroke patients.
Pro-inflammatory cytokines and neurotrophins in the central nervous system (CNS) have been recognized as mediators of both neurodegenerative and neuroprotective mechanisms in a number of CNS pathologies. A rapid, sustained elevation of these molecules was recently reported after traumatic and ischemic brain injury. Inflammatory mechanisms and immune activation have been hypothesized to play a role in the pathogenesis of cerebral ischemia. Stroke is the third largest cause of death next to heart disease and cancer in the world, and it is an important cause of death and disability in developed countries. Role of excitatory amino acids receptors activation, calcium overload, nitric oxide and oxidative stress in the pathogenesis of ischemic brain damage is well established. Stroke may modulate peripheral neurotrophic factors levels. In experimental animal models, neurotrophin-3 (NT-3) has been shown to be produced by glial cells as an adaptability response to hypoxia. In spite of substantial research and significant number of neuroprotective drugs that have been developed to limit ischemic brain damage and to improve the outcome for stroke patients, no specific therapy for stroke is available. The neurotrophins have been proposed as therapeutic agents for the treatment of neurodegenerative disorders and ischemic injury. In the present work, we investigated the possible correlation of NT-3 with tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) in the serum and cerebrospinal fluid (CSF) from patients with ischemic stroke (IS).
Pasarica
Daniela
D
"Carol Davila" University of Medicine and Pharmacy, Pathophysiology and Immunology Department, Bucharest, Romania.
Gheorghiu
Mihaela
M
Topârceanu
Florica
F
Bleotu
Coralia
C
Ichim
Loretta
L
Trandafir
T
T
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood / Q000134:cerebrospinal fluid; D003289:Convalescence; D006801:Humans; D015850:Interleukin-6 / Q000097:blood* / Q000134:cerebrospinal fluid*; D008875:Middle Aged; D020933:Neurotrophin 3 / Q000097:blood* / Q000134:cerebrospinal fluid*; D020521:Stroke / Q000097:blood* / Q000134:cerebrospinal fluid* / Q000503:physiopathology; D014409:Tumor Necrosis Factor-alpha / Q000097:blood* / Q000134:cerebrospinal fluid*
D015415:Biomarkers; D015850:Interleukin-6; D020933:Neurotrophin 3; D014409:Tumor Necrosis Factor-alpha