title: Long-term use of cellular phones and brain tumours: increased risk associated with use for > or =10 years.
abstract: OBJECTIVE
  To evaluate brain tumour risk among long-term users of cellular telephones.
  
  
  METHODS
  Two cohort studies and 16 case-control studies on this topic were identified. Data were scrutinised for use of mobile phone for > or =10 years and ipsilateral exposure if presented.
  
  
  RESULTS
  The cohort study was of limited value due to methodological shortcomings in the study. Of the 16 case-control studies, 11 gave results for > or =10 years' use or latency period. Most of these results were based on low numbers. An association with acoustic neuroma was found in four studies in the group with at least 10 years' use of a mobile phone. No risk was found in one study, but the tumour size was significantly larger among users. Six studies gave results for malignant brain tumours in that latency group. All gave increased odd ratios (OR), especially for ipsilateral exposure. In a meta-analysis, ipsilateral cell phone use for acoustic neuroma was OR = 2.4 (95% CI 1.1 to 5.3) and OR = 2.0, (1.2 to 3.4) for glioma using a tumour latency period of > or =10 years.
  
  
  CONCLUSIONS
  Results from present studies on use of mobile phones for > or =10 years give a consistent pattern of increased risk for acoustic neuroma and glioma. The risk is highest for ipsilateral exposure.
authors.affiliation: Department of Oncology, University Hospital, Orebro, Sweden. lennart.hardell@orebroll.se
authors.forename: Lennart
authors.initials: L
authors.lastname: Hardell
authors.forename: Michael
authors.initials: M
authors.lastname: Carlberg
authors.forename: Fredrik
authors.initials: F
authors.lastname: Söderqvist
authors.forename: Kjell Hansson
authors.initials: KH
authors.lastname: Mild
authors.forename: L Lloyd
authors.initials: LL
authors.lastname: Morgan
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000209:etiology* / Q000401:mortality; D040421:Cell Phone; D004812:Epidemiologic Methods; D005260:Female; D005910:Glioma / Q000209:etiology* / Q000401:mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D009381:Neoplasms, Radiation-Induced / Q000209:etiology* / Q000401:mortality; D009464:Neuroma, Acoustic / Q000209:etiology* / Q000401:mortality