Satoyoshi syndrome has antibody against brain and gastrointestinal tissue.
Satoyoshi syndrome is a rare postnatal disorder with muscle spasms, alopecia, and diarrhea of unknown etiology. Nutritional deficiency seems to influence lifespan. We present a patient with this syndrome having a unique "mesh-like" mucosal change radiographically and white granules endoscopically in the gastrointestinal tract. A common antibody against brain, stomach, and duodenal tissue, according to Western blot analysis, was detected in the sera of two patients with this syndrome. These findings suggest that Satoyoshi syndrome is a systemic autoimmune disease involving the nervous, endocrine, and gastrointestinal systems.
Matsuura
Eiji
E
Department of Neurology and Geriatrics, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan.
Matsuyama
Wataru
W
Sameshima
Tomoyuki
T
Arimura
Kimiyoshi
K
D000293:Adolescent; D000505:Alopecia / Q000175:diagnosis / Q000276:immunology* / Q000473:pathology; D001323:Autoantibodies / Q000097:blood*; D001327:Autoimmune Diseases / Q000175:diagnosis / Q000276:immunology* / Q000473:pathology; D001921:Brain / Q000276:immunology; D003967:Diarrhea / Q000175:diagnosis / Q000276:immunology* / Q000473:pathology; D004724:Endoscopy; D005260:Female; D005753:Gastric Mucosa / Q000276:immunology / Q000473:pathology; D006801:Humans; D013035:Spasm / Q000175:diagnosis / Q000276:immunology*; D013270:Stomach / Q000276:immunology; D013577:Syndrome
D001323:Autoantibodies