title: Successful medical treatment of cutaneous aspergillosis in a premature infant using liposomal amphotericin B, voriconazole and micafungin.
abstract: Treatment options for primary cutaneous aspergillosis in neonates are limited by the lack of pharmacokinetic and safety data of newer antifungal agents that are effective against Aspergillus spp. We report the successful treatment of cutaneous aspergillosis in an extremely low-birth-weight preterm infant with liposomal amphotericin B, voriconazole and micafungin, and provide pharmacokinetic profiles for voriconazole and micafungin.
authors.affiliation: Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390-9063, USA. roberto.santos@UTSouthwestern.edu
authors.forename: Roberto P
authors.initials: RP
authors.lastname: Santos
authors.forename: Pablo J
authors.initials: PJ
authors.lastname: Sánchez
authors.forename: Asuncion
authors.initials: A
authors.lastname: Mejias
authors.forename: Daniel K
authors.initials: DK
authors.lastname: Benjamin
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Walsh
authors.forename: Sanjay
authors.initials: S
authors.lastname: Patel
authors.forename: Hasan S
authors.initials: HS
authors.lastname: Jafri
mesh_terms: D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use*; D001228:Aspergillosis / Q000188:drug therapy* / Q000382:microbiology; D003881:Dermatomycoses / Q000188:drug therapy* / Q000382:microbiology; D054714:Echinocandins; D006801:Humans; D052577:Infant, Extremely Low Birth Weight; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000188:drug therapy* / Q000382:microbiology; D055666:Lipopeptides; D008074:Lipoproteins / Q000627:therapeutic use; D000077551:Micafungin; D010456:Peptides, Cyclic / Q000627:therapeutic use; D011743:Pyrimidines / Q000627:therapeutic use; D016896:Treatment Outcome; D014230:Triazoles / Q000627:therapeutic use; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D008074:Lipoproteins; D010456:Peptides, Cyclic; D011743:Pyrimidines; D014230:Triazoles; C068538:liposomal amphotericin B; D000666:Amphotericin B; D065819:Voriconazole; D000077551:Micafungin