title: Pooled analysis and meta-analysis of the glutathione S-transferase P1 Ile 105Val polymorphism and bladder cancer: a HuGE-GSEC review.
abstract: The glutathione S-transferase P1 genotype (GSTP1) is involved in the inactivation of cigarette smoke carcinogens, and sequence variation in the gene may alter bladder cancer susceptibility. To examine the association between GSTP1Ile 105Val and bladder cancer, the authors undertook a meta- and pooled analysis. Summary crude and adjusted odds ratios and corresponding 95% confidence intervals were pooled by using a random-effects model. In the meta-analysis (16 studies, 4,273 cases and 5,081 controls), the unadjusted summary odds ratios for GSTP1 Ile/Val and Val/Val compared with GSTP1 Ile/Ile were 1.54 (95% confidence interval: 1.21, 1.99; p < 0.001) and 2.17 (95% confidence interval: 1.27, 3.71; p = 0.005). The association appeared to be the strongest in Asian countries. When the analysis was limited to European descendents (nine studies), the summary odds ratio decreased (odds ratio = 1.24, 95% confidence interval: 1.00, 1.52) (Q = 17.50; p = 0.02). All relevant data previously contributed to the International Study on Genetic Susceptibility to Environmental Carcinogens were pooled (eight studies, 1,305 cases and 1,558 controls). The summary odds ratios were similar to the ones from the meta-analysis. Case-only analyses did not detect an interaction between the GSTP1 genotype and smoking status (never/ever). GSTP1 Ile 105Val appears to be associated with a modest increase in the risk of bladder cancer.
authors.affiliation: Department of General Practice, Katholieke Universiteit Leuven, Comprehensive Cancer Institute Limburg, Limburg, Belgium. Eliane.Kellen@med.kuleuven.be
authors.forename: Eliane
authors.initials: E
authors.lastname: Kellen
authors.forename: Marjolein
authors.initials: M
authors.lastname: Hemelt
authors.forename: Karin
authors.initials: K
authors.lastname: Broberg
authors.forename: Klaus
authors.initials: K
authors.lastname: Golka
authors.forename: Vessela Nedelcheva
authors.initials: VN
authors.lastname: Kristensen
authors.forename: Rayjean J
authors.initials: RJ
authors.lastname: Hung
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Matullo
authors.forename: Rama D
authors.initials: RD
authors.lastname: Mittal
authors.forename: Stefano
authors.initials: S
authors.lastname: Porru
authors.forename: Andrew
authors.initials: A
authors.lastname: Povey
authors.forename: Wolfgang A
authors.initials: WA
authors.lastname: Schulz
authors.forename: Jianhua
authors.initials: J
authors.lastname: Shen
authors.forename: Frank
authors.initials: F
authors.lastname: Buntinx
authors.forename: Maurice P
authors.initials: MP
authors.lastname: Zeegers
authors.forename: Emanuela
authors.initials: E
authors.lastname: Taioli
mesh_terms: D001208:Asia / Q000453:epidemiology; D016022:Case-Control Studies; D005060:Europe / Q000453:epidemiology; D020022:Genetic Predisposition to Disease; D051549:Glutathione S-Transferase pi / Q000235:genetics*; D006801:Humans; D016015:Logistic Models; D011110:Polymorphism, Genetic; D012306:Risk; D012907:Smoking / Q000009:adverse effects; D014481:United States / Q000453:epidemiology; D001749:Urinary Bladder Neoplasms / Q000453:epidemiology* / Q000209:etiology / Q000235:genetics*
chemical_list: C496556:GSTP1 protein, human; D051549:Glutathione S-Transferase pi