title: Repair of cranial bone defects with calcium phosphate ceramic implant or autogenous bone graft.
abstract: Autogenous bone grafts have frequently been used in the treatment of bone defects; however, this procedure can cause clinical complications after surgery. Besides, the amount of available bone is sometimes insufficient. Therefore, synthetic biomaterials have been researched as an alternative to autogenous bone graft implants. The objective of this study was to evaluate the repair of bone defects treated with compact autogenous bone graft or porous calcium phosphate ceramics. Three defects 3 mm in diameter were produced in the skull of 21 rats. One the defects was produced in the frontal bone, which remained empty, while the others were produced in the right and left parietal bones, which were filled respectively with ceramics and autogenous bone graft. The animals were sacrificed 1, 2, 4, and 24 weeks after surgery and analyzed by light microscopy and radiography. In the twenty-fourth week, the defects filled with autogenous bone graft and ceramics had similar volumes of newly formed bone tissue. The ceramics offered favorable conditions to bone tissue growth. Thus, we concluded that the calcium phosphate ceramic implant proved to be effective in repairing defects produced in the skull of rats.
authors.affiliation: State University of Campinas-UNICAMP, Institute of Biology/Department of Anatomy, Campinas, Brazil.
authors.forename: Rosane Vieira
authors.initials: RV
authors.lastname: da Silva
authors.forename: Celso Aparecido
authors.initials: CA
authors.lastname: Bertran
authors.forename: Elizabete Yoshie
authors.initials: EY
authors.lastname: Kawachi
authors.forename: José Angelo
authors.initials: JA
authors.lastname: Camilli
mesh_terms: D000818:Animals; D001861:Bone Regeneration; D018786:Bone Substitutes; D016025:Bone Transplantation; D002130:Calcium Phosphates; D002516:Ceramics; D003399:Craniotomy / Q000379:methods*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012886:Skull / Q000601:surgery
chemical_list: D018786:Bone Substitutes; D002130:Calcium Phosphates