Fabrication of ultrathin polyelectrolyte fibers and their controlled release properties.
Ultrathin fibers comprising 2-weak polyelectrolytes, poly(acrylic acid) (PAA) and poly(allylamine hydrochloride) (PAH) were fabricated using the electrospinning technique. Methylene blue (MB) was used as a model drug to evaluate the potential application of the fibers for drug delivery. The release of MB was controlled in a nonbuffered medium by changing the pH of the solution. The sustained release of MB in a phosphate buffered saline (PBS) solution was achieved by constructing perfluorosilane networks on the fiber surfaces as capping layers. Temperature controlled release of MB was obtained by depositing temperature sensitive PAA/poly(N-isopropylacrylamide) (PNIPAAM) multilayers onto the fiber surfaces. The controlled release of drugs from electrospun fibers have potential applications as drug carriers in biomedical science.
Chunder
Anindarupa
A
NanoScience Technology Center and Department of Chemistry, University of Central Florida, Orlando, FL 32826, USA.
Sarkar
Sourangsu
S
Yu
Yingbo
Y
Zhai
Lei
L
D000180:Acrylic Resins / Q000737:chemistry*; D016503:Drug Delivery Systems; D004573:Electrolytes / Q000737:chemistry*; D008751:Methylene Blue / Q000008:administration & dosage / Q000493:pharmacokinetics; D011073:Polyamines / Q000737:chemistry*
D000180:Acrylic Resins; D004573:Electrolytes; D011073:Polyamines; C063994:polyallylamine; C006903:carbopol 940; D008751:Methylene Blue