title: Synthetic Studies Toward Bryostatin 1: Preparation of a C(1)-C(16) Fragment by Pyran Annulation.
abstract: An expeditious assembly of a C(1)-C(16) subunit of bryostatin 1 is described. A pyran annulation reaction was utilized to form the B-ring by reaction of a hydroxy-allylsilane with a fully elaborated A-ring subunit. This annulation process proceeded with complete diastereoselectivity and in excellent isolated yield despite the presence of potentially sensitive functionality in the A-ring segment.
authors.affiliation: Department of Chemistry, University of Utah, 315 South 1400 East, RM 2020, Salt Lake City, Utah 84112-0850, USA.
authors.forename: Gary E
authors.initials: GE
authors.lastname: Keck
authors.forename: Dennie S
authors.initials: DS
authors.lastname: Welch
authors.forename: Yam B
authors.initials: YB
authors.lastname: Poudel