Peculiarities of autonomic regulation assessed by variability of hemodynamic parameters in rats with different stress resistance.
Analysis of contribution of sympathetic and parasympathetic systems into heart rate variability carried out using atenolol and atropine showed that August rats are characterized by enhanced tone of the sympathetic system and reduced tone of the parasympathetic system compared to Wistar rats. Reduced tone of the parasympathetic system is also confirmed by lower sensitivity of the baroreflex. Blockade of NO synthesis with Nw-nitro-L-arginine more markedly increased blood pressure variability in August rats compared to Wistar rats. The data attest to a certain rigidity of the autonomic cardiovascular regulation in August rats.
Kirillina
T N
TN
State Research Institute of General Pathology and Pathological Physiology, Russian Academy of Medical Sciences, Moscow.
Usacheva
M A
MA
Belkina
L M
LM
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000818:Animals; D001262:Atenolol / Q000494:pharmacology; D001285:Atropine / Q000494:pharmacology; D001341:Autonomic Nervous System / Q000187:drug effects / Q000502:physiology*; D001794:Blood Pressure; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D010275:Parasympathetic Nervous System / Q000187:drug effects / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D013045:Species Specificity; D013564:Sympathetic Nervous System / Q000187:drug effects / Q000502:physiology
D000319:Adrenergic beta-Antagonists; D001262:Atenolol; D001285:Atropine