title: Gene discovery in diabetic nephropathy.
abstract: Diabetic nephropathy affects approximately one third of diabetic patients and is the leading cause of end-stage renal disease. Identification of genetic susceptibility factors contributing to the development of diabetic nephropathy could facilitate prediction, development of improved treatments, and prevention of this devastating complication of diabetes. Although investigations to identify the causal genetic variants associated with diabetic nephropathy have been inconclusive, new approaches, including whole genome association scanning, offer hope for the future.
authors.affiliation: Nephrology Research Laboratory, Queen's University Belfast, Regional Genetics Centre, Belfast City Hospital, Lisburn Road, Belfast BT9 7AB, Northern Ireland. d.savage@qub.ac.uk
authors.forename: David A
authors.initials: DA
authors.lastname: Savage
authors.forename: Stephen C
authors.initials: SC
authors.lastname: Bain
authors.forename: Amy Jayne
authors.initials: AJ
authors.lastname: McKnight
authors.forename: A Peter
authors.initials: AP
authors.lastname: Maxwell
mesh_terms: D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000235:genetics; D003928:Diabetic Nephropathies / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D015894:Genome, Human / Q000235:genetics; D006801:Humans