title: Modification of C2 functional group on asiatic acid and the evaluation of hepatoprotective effects.
abstract: For the development of novel hepatoprotective agents, C2 functional group on asiatic acid was modified, and evaluated for their hepatoprotective effects. Among prepared compounds, compounds 10 and 14 showed better hepatoprotective effects compared to silymarin.
authors.affiliation: College of Pharmacy, Yeungnam University, Kyongsan 712-749, Korea.
authors.forename: Byeong-Seon
authors.initials: BS
authors.lastname: Jeong
authors.forename: Mi Kyeong
authors.initials: MK
authors.lastname: Lee
authors.forename: Young Choong
authors.initials: YC
authors.lastname: Kim
authors.forename: Eung-Seok
authors.initials: ES
authors.lastname: Lee
mesh_terms: D000818:Animals; D002251:Carbon Tetrachloride / Q000633:toxicity; D002478:Cells, Cultured; D005688:Galactosamine / Q000633:toxicity; D008099:Liver / Q000187:drug effects*; D008297:Male; D053978:Pentacyclic Triterpenes; D020011:Protective Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship; D014315:Triterpenes / Q000138:chemical synthesis / Q000494:pharmacology*
chemical_list: D053978:Pentacyclic Triterpenes; D020011:Protective Agents; D014315:Triterpenes; D005688:Galactosamine; C017032:asiatic acid; D002251:Carbon Tetrachloride