title: Assessment of infant brain development with frequency-domain near-infrared spectroscopy.
abstract: This is the first report to demonstrate quantitative monitoring of infant brain development with frequency-domain near-infrared spectroscopy (FD-NIRS). Regionally specific increases in blood volume and oxygen consumption were measured in healthy infants during their first year. The results agree with prior PET and SPECT reports; but, unlike these methods, FD-NIRS is portable and uses nonionizing radiation. Further, new information includes the relatively constant tissue oxygenation with age and location, suggesting a tight control between local oxygen delivery and consumption in healthy infants during brain development. FD-NIRS could become the preferred clinical tool for quantitatively assessing infant brain development.
authors.affiliation: Athinoula A. Martinos Center, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA. mari@nmr.mgh.harvard.edu
authors.forename: Maria Angela
authors.initials: MA
authors.lastname: Franceschini
authors.forename: Sonal
authors.initials: S
authors.lastname: Thaker
authors.forename: George
authors.initials: G
authors.lastname: Themelis
authors.forename: Kalpathy K
authors.initials: KK
authors.lastname: Krishnamoorthy
authors.forename: Heather
authors.initials: H
authors.lastname: Bortfeld
authors.forename: Solomon G
authors.initials: SG
authors.lastname: Diamond
authors.forename: David A
authors.initials: DA
authors.lastname: Boas
authors.forename: Kara
authors.initials: K
authors.lastname: Arvin
authors.forename: P Ellen
authors.initials: PE
authors.lastname: Grant
mesh_terms: D001921:Brain / Q000033:anatomy & histology / Q000254:growth & development* / Q000502:physiology*; D002560:Cerebrovascular Circulation; D006801:Humans; D007223:Infant; D008297:Male; D010101:Oxygen Consumption; D012039:Regional Blood Flow; D019265:Spectroscopy, Near-Infrared / Q000379:methods*