title: Effect of surgically removing subcutaneous fat by abdominoplasty on leptin concentrations and insulin sensitivity.
abstract: The aim of this study was to identify the effect of surgically removing subcutaneous fat by abdominoplasty on leptin concentrations and insulin sensitivity. An open clinical trial with a noninterventional parallel group was carried out in 12 obese women. After randomization, 6 volunteers were selected for abdominoplasty, and the other 6 women were considered as the noninterventional group. A metabolic profile, including leptin concentrations, and insulin tolerance test to assess insulin sensitivity were performed on all volunteers before intervention or nonintervention and 40-50 days afterward. A significant reduction in body mass index (30.7 +/- 0.9 versus 29.6 +/- 0.7 kg/m; P = 0.02) and in leptin concentrations (41.3 +/- 10.6 versus 32.0 +/- 10.2 ng/mL; P = 0.02) was observed after abdominoplasty. Insulin sensitivity did not change after intervention. In conclusion, surgically removing subcutaneous fat by abdominoplasty decreased leptin concentrations, with no change in insulin sensitivity.
authors.affiliation: Medical Research Unit in Clinical Epidemiology, Mexican Institute of Social Security, Guadalajara, Mexico. uiec@prodigy.net.mx
authors.forename: Esperanza
authors.initials: E
authors.lastname: Martínez-Abundis
authors.forename: Carlos Alejandro
authors.initials: CA
authors.lastname: Molina-Villa
authors.forename: Manuel
authors.initials: M
authors.lastname: González-Ortiz
authors.forename: José Antonio
authors.initials: JA
authors.lastname: Robles-Cervantes
authors.forename: José Antonio
authors.initials: JA
authors.lastname: Saucedo-Ortiz
mesh_terms: D000328:Adult; D015992:Body Mass Index; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D020738:Leptin / Q000097:blood*; D008875:Middle Aged; D009765:Obesity / Q000378:metabolism* / Q000601:surgery*; D018709:Statistics, Nonparametric; D050151:Subcutaneous Fat / Q000378:metabolism* / Q000601:surgery*
chemical_list: D020738:Leptin