title: [The plasma levels of granulocyte-colony stimulating factor (G-CSF) and macrophage-colony stimulating factor (M-CSF) in breast cancer patients].
abstract: We have investigated the plasma levels of G-CSF and M-CSF and commonly accepted tumor marker CA 15-3 in 54 breast cancer patients before and after surgery and chemotherapy. The patients were divided into two groups: A (stage I) and B (stage II). G-CSF i M-CSF were determined using enzyme-linked immunosorbent assay (ELISA), CA 15-3 was measured by microparticle enzyme immunoassay (MEIA). G-CSF and M-CSF plasma levels (similarly as CA 15-3) were significantly higher in breast cancer patients before surgery comparing to the control group. After surgery plasma level of G-CSF (as CA 15-3) was decreased, but M-CSF increased. The plasma levels of tested cytokines and CA 15-3 increased after chemotherapy. This study suggests that tested cytokines (especially G-CSF) can be clinically useful in diagnostics of breast cancer, yet further investigation and confirmation by a prospective study are necessary.
authors.affiliation: Zakład Diagnostyki Biochemicznej AM w Białymstoku.
authors.forename: Sławomir
authors.initials: S
authors.lastname: Lawicki
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Czygier
authors.forename: Jacek
authors.initials: J
authors.lastname: Omyła
authors.forename: Maciej
authors.initials: M
authors.lastname: Szmitkowski
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D001943:Breast Neoplasms / Q000097:blood* / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology / Q000601:surgery; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000097:blood*; D006801:Humans; D016173:Macrophage Colony-Stimulating Factor / Q000097:blood*; D008875:Middle Aged; D018396:Mucin-1 / Q000097:blood; D009367:Neoplasm Staging; D012680:Sensitivity and Specificity
chemical_list: D014408:Biomarkers, Tumor; D018396:Mucin-1; D016179:Granulocyte Colony-Stimulating Factor; D016173:Macrophage Colony-Stimulating Factor