Evaluation of Tectona grandis leaves for wound healing activity.
The frontal leaves of Tectona grandis (Verabinaceae) are widely used in the folklore for the treatment of various kinds of wounds, especially burn wound. The present study was carried out to evaluate the effect of hydrochloric extract of Tectona grandis on experimentally induced wounds in rats and compare the effects observed with a known wound healing agent, Aloe vera. The models selected were excision wound, incision wound, burn wound and dead space wound. A suitable gel formulation was selected for the application using cellophane membrane penetration. In the excision wound and burn wound models, animals treated with Tectona grandis leaf extract showed significant reduction in period of epithelisation and wound contraction 50%. In the incision wound model, a significant increase in the breaking strength was observed. Tectona grandis leaf extract treatment orally produced a significant increase in the breaking strength, dry weight and hydroxyproline content of the granulation tissue in dead space wound. It was concluded that Tectona grandis leaf extract applied topically (5% and 10% gel formulation) or administered orally (250 mg and 500 mg/kg body weight) possesses wound healing activity.
Majumdar
Mrityunjoy
M
Krupanidhi College of Pharmacy, Koramangala, Bangalore-560 034, India.
Nayeem
Naira
N
Kamath
Jagadish V
JV
Asad
Mohammed
M
D000284:Administration, Oral; D000287:Administration, Topical; D000504:Aloe; D000818:Animals; D002056:Burns / Q000188:drug therapy* / Q000503:physiopathology; D002626:Chemistry, Pharmaceutical; D062109:Dermatologic Surgical Procedures; D004195:Disease Models, Animal; D004337:Drug Carriers; D004339:Drug Compounding; D005782:Gels; D006097:Granulation Tissue / Q000187:drug effects* / Q000378:metabolism; D006358:Hot Temperature; D006851:Hydrochloric Acid / Q000737:chemistry; D006909:Hydroxyproline / Q000378:metabolism; D065347:Hypromellose Derivatives; D008297:Male; D008747:Methylcellulose / Q000031:analogs & derivatives / Q000737:chemistry; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D018515:Plant Leaves; D051381:Rats; D017208:Rats, Wistar; D012867:Skin / Q000187:drug effects* / Q000503:physiopathology; D012997:Solvents / Q000737:chemistry; D029648:Verbenaceae; D014945:Wound Healing / Q000187:drug effects*; D014950:Wounds, Penetrating / Q000188:drug therapy* / Q000503:physiopathology
D004337:Drug Carriers; D005782:Gels; D010936:Plant Extracts; D012997:Solvents; D065347:Hypromellose Derivatives; D008747:Methylcellulose; D006851:Hydrochloric Acid; D006909:Hydroxyproline