How a home-grown T cell receptor interacts with a foreign landscape.
The ability of a T cell receptor (TCR) to directly recognize foreign (allogeneic)-major histocompatibility complex (MHC) molecules underlies T cell-mediated rejection in patients receiving allogeneic organ transplants. In this issue, Colf et al. (2007) reveal that instead of mimicking the interactions formed with a self MHC, a single TCR adopts a completely different strategy to recognize a foreign MHC.
Rossjohn
Jamie
J
The Protein Crystallography Unit, Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Victoria 3800, Australia. jamie.rossjohn@med.monash.edu.au <jamie.rossjohn@med.monash.edu.au>
McCluskey
James
J
D000818:Animals; D001324:Autoantigens / Q000276:immunology*; D006801:Humans; D007519:Isoantigens / Q000276:immunology*; D008285:Major Histocompatibility Complex / Q000276:immunology*; D018448:Models, Immunological; D011948:Receptors, Antigen, T-Cell / Q000737:chemistry / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology; D014184:Transplantation, Homologous
D001324:Autoantigens; D007519:Isoantigens; D011948:Receptors, Antigen, T-Cell