title: The Brugada syndrome.
abstract: OBJECTIVE
  The Brugada syndrome has been an area of intensive investigation since its earliest description in 1992, both on a clinical and on a basic research level. In this review, we will focus on recent achievements in the molecular dissection of the disease pathophysiology and on large multicenter studies dealing with prognostic markers and the natural history of the Brugada syndrome.
  
  
  RESULTS
  In the past year, two additional genetic pathways have been associated with the disease. Also, an inflammatory or infectious etiology has recently been linked with the Brugada syndrome. The debate on the predictive role of programmed electrical stimulation is still ongoing. Very recently, large follow-up studies questioned the prognostic role of programmed electrical stimulation in this disease.
  
  
  CONCLUSIONS
  Knowledge on the genetic determinants of the Brugada syndrome remains limited. Therefore, the management and the risk stratification of patients should be performed on a clinical basis. Sufficient evidence exists to reassure clinicians who feel reluctant to include programmed electrical stimulation in the risk stratification strategy of asymptomatic Brugada syndrome patients.
authors.affiliation: Molecular Cardiology, IRCCS Fondazione Maugeri, Pavia, Italy.
authors.forename: Tom
authors.initials: T
authors.lastname: Rossenbacker
authors.forename: Silvia G
authors.initials: SG
authors.lastname: Priori
mesh_terms: D001341:Autonomic Nervous System / Q000503:physiopathology; D053840:Brugada Syndrome / Q000175:diagnosis / Q000235:genetics* / Q000503:physiopathology; D016757:Death, Sudden, Cardiac; D020022:Genetic Predisposition to Disease; D036281:Genetic Research; D006801:Humans; D009124:Muscle Proteins / Q000235:genetics; D062554:NAV1.5 Voltage-Gated Sodium Channel; D018570:Risk Assessment; D012307:Risk Factors; D015222:Sodium Channels / Q000235:genetics
chemical_list: D009124:Muscle Proteins; D062554:NAV1.5 Voltage-Gated Sodium Channel; C568320:SCN5A protein, human; D015222:Sodium Channels