title: The P239S palladin variant does not account for a significant fraction of hereditary or early onset pancreas cancer.
abstract: The P239S palladin variant has recently been suggested to play a role in hereditary pancreatic cancer. We estimated the contribution of the P239S variant, and surrounding sequence, to familial and early-onset pancreatic cancer. The P239S germline variant was identified in one of 84 high-risk cases and one of 555 controls. The case reported an elderly relative with pancreas cancer. We conclude that this variant does not appear to account for a significant fraction of hereditary or early-onset pancreas cancer.
authors.affiliation: Sam Minuk Cancer Genetics and Biomarker Laboratories, Samuel Lunenfeld Research Institute, Toronto, Ontario, Canada.
authors.forename: George
authors.initials: G
authors.lastname: Zogopoulos
authors.forename: Heidi
authors.initials: H
authors.lastname: Rothenmund
authors.forename: Ayelet
authors.initials: A
authors.lastname: Eppel
authors.forename: Colleen
authors.initials: C
authors.lastname: Ash
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Akbari
authors.forename: David
authors.initials: D
authors.lastname: Hedley
authors.forename: Steven A
authors.initials: SA
authors.lastname: Narod
authors.forename: Steven
authors.initials: S
authors.lastname: Gallinger
mesh_terms: D000368:Aged; D003598:Cytoskeletal Proteins / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D010190:Pancreatic Neoplasms / Q000235:genetics*; D010750:Phosphoproteins / Q000235:genetics*
chemical_list: D003598:Cytoskeletal Proteins; C412722:PALLD protein, human; D010750:Phosphoproteins