title: Depletion of ovarian follicles with age in chimpanzees: similarities to humans.
abstract: We retrieved ovarian sections taken from necropsies of 19 captive chimpanzees (Pan troglodytes) aged 0-47 yr, counted the number of primordial follicles in each, and compared the rate of decline in numbers to declines previously documented in humans. The follicular depletion rate in this sample was indistinguishable from that shown across the same ages in classic human data sets. This result supports earlier suggestions that ovarian senescence occurs at the same ages in chimpanzees and humans, implying that the influence of declining ovarian function on other physiologic systems may be distinctively buffered in humans.
authors.affiliation: University of Utah School of Medicine, Department of Obstetrics and Gynecology, Salt Lake City, Utah 84132-2209, USA.
authors.forename: K P
authors.initials: KP
authors.lastname: Jones
authors.forename: L C
authors.initials: LC
authors.lastname: Walker
authors.forename: D
authors.initials: D
authors.lastname: Anderson
authors.forename: A
authors.initials: A
authors.lastname: Lacreuse
authors.forename: S L
authors.initials: SL
authors.lastname: Robson
authors.forename: K
authors.initials: K
authors.lastname: Hawkes
mesh_terms: D000328:Adult; D000375:Aging; D000818:Animals; D005260:Female; D006801:Humans; D008875:Middle Aged; D006080:Ovarian Follicle / Q000033:anatomy & histology*; D002679:Pan troglodytes / Q000033:anatomy & histology* / Q000502:physiology*