title: Antibiotic-containing collagen for the treatment of bone defects.
abstract: Recent studies have explored the use of biodegradable implants that incorporate antibiotics for the treatment of bone infections. In this study, a biodegradable composite containing bovine collagen and teicoplanin (Targobone) was used for the treatment of mandibular nonunion defects. Patients with mandibular nonunion defects subsequent to osteosynthesis were treated with Targobone (n = 9) or with autologous bone grafts (n = 12). Clinical and radiological evaluations were performed preoperatively, immediately postoperatively, and 4 and 24 weeks postoperatively. Bone regeneration was defined relative to the original defect area in the panoramic radiograph by using image analysis software. In the Targobone group, the defect area decreased to 78% (SD +/- 21.8%) of the preoperative area within 4 weeks and to 21% (SD +/- 9.7%) of the preoperative area within 24 weeks. In the autologous bone graft group, the defect area decreased to 69% (SD +/- 32.4%) of the preoperative area within 4 weeks and to 4.7% (SD +/- 5.6%) of the preoperative area within 24 weeks. Thus, Targobone is a promising option for the treatment of bone defects.
authors.affiliation: Oral and Maxillofacial Surgery, Friedrich Alexander University Erlangen-Nuremberg, Germany. rupprecht@mkg-erlangen.de
authors.forename: Stephan
authors.initials: S
authors.lastname: Rupprecht
authors.forename: Ljubinko
authors.initials: L
authors.lastname: Petrovic
authors.forename: Bettina
authors.initials: B
authors.lastname: Burchhardt
authors.forename: Jörg
authors.initials: J
authors.lastname: Wiltfang
authors.forename: Friedrich Wilhelm
authors.initials: FW
authors.lastname: Neukam
authors.forename: Karl Andreas
authors.initials: KA
authors.lastname: Schlegel
mesh_terms: D020341:Absorbable Implants; D000328:Adult; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000737:chemistry; D001861:Bone Regeneration; D018786:Bone Substitutes / Q000627:therapeutic use*; D002417:Cattle; D003094:Collagen / Q000737:chemistry / Q000627:therapeutic use*; D004338:Drug Combinations; D005260:Female; D006801:Humans; D008297:Male; D008338:Mandibular Injuries / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000601:surgery; D008875:Middle Aged; D011446:Prospective Studies; D011859:Radiography; D017334:Teicoplanin / Q000008:administration & dosage* / Q000737:chemistry / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D018786:Bone Substitutes; D004338:Drug Combinations; C525205:targobone; D017334:Teicoplanin; D003094:Collagen