Suppression of cell-mediated immunity by a donor-transmitted lymphocytic choriomeningitis virus in a kidney transplant recipient.
Infection with lymphocytic choriomeningitis virus (LCMV) in rodents, the primary host, is known to cause suppression of cell-mediated immunity. Serial determinations using a functional cell-mediated immune assay in a kidney transplant recipient with donor-transmitted LCMV also suggested profound suppression of cellular immunity. This suppression persisted in spite of reduction of immunosuppression. With the clearance of the virus there was reconstitution of the cellular immune response.
Gautam
Amitabh
A
Division of Organ Transplantation, Rhode Island Hospital, Brown Medical School, Providence, Rhode Island 02903, USA. agautam@lifespan.org
Fischer
S A
SA
Yango
A F
AF
Gohh
R Y
RY
Morrissey
P E
PE
Monaco
A P
AP
D005260:Female; D006801:Humans; D007111:Immunity, Cellular / Q000276:immunology*; D007165:Immunosuppression Therapy; D007668:Kidney / Q000821:virology*; D016030:Kidney Transplantation / Q000009:adverse effects*; D008216:Lymphocytic Choriomeningitis / Q000276:immunology* / Q000473:pathology; D008217:Lymphocytic choriomeningitis virus / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D014019:Tissue Donors