title: Long-term effect of optic edge design in a silicone intraocular lens on posterior capsule opacification.
abstract: OBJECTIVE
  To compare the posterior capsule opacification (PCO) inhibiting effect of the round anterior and sharp posterior optic edge profile of the Clariflex silicone intraocular lens (IOL) [AMO Inc, Santa Ana, California, USA] with that of the double-round edge profile of the SI40 (Phacoflex; AMO Inc, Santa Ana, California, USA) silicone IOL over a period of three years.
  
  
  METHODS
  Prospective, randomized, double-masked, bilateral clinical trial.
  
  
  METHODS
  The study took place at the Department of Ophthalmology, Medical University of Vienna, Austria. Fifty-two patients with age-related cataracts (104 eyes) were included in the study. Each patient received an SI40 IOL (round edges) in one eye and a Clariflex IOL with OptiEdge (sharp posterior optic edge) in the other eye. Follow-up examinations were at one week, one month, six months, and one, two, and three years. Digital retroillumination images were taken of each eye. The amount of PCO was subjectively assessed with the slit-lamp and objectively assessed by automated image analysis software (the computer program Automated Quantification of After-Cataract [AQUA]; Vienna, Austria) one, two, and three years after surgery.
  
  
  RESULTS
  The Clariflex lens showed markedly less PCO at one, two, and three years after surgery. The mean AQUA PCO score was 1.39 for the SI40 and 0.56 for the Clariflex lens after one year, estimated at 1.64 and 0.57 after two years, and at 2.04 and 0.64, respectively, after three years (scale zero to 10; P < .001). The Nd:YAG laser capsulotomy rate was far higher in the SI40 group (Five cases vs one case at three years).
  
  
  CONCLUSIONS
  The sharp posterior optic edge profile of the Clariflex silicone IOL led to marked and consistently less PCO than the round-edged SI40 IOL one, two, and three years after surgery.
authors.affiliation: Department of Ophthalmology, Medical University of Vienna, Vienna, Austria.
authors.forename: Wolf
authors.initials: W
authors.lastname: Buehl
authors.forename: Rupert
authors.initials: R
authors.lastname: Menapace
authors.forename: Oliver
authors.initials: O
authors.lastname: Findl
authors.forename: Thomas
authors.initials: T
authors.lastname: Neumayer
authors.forename: Matthias
authors.initials: M
authors.lastname: Bolz
authors.forename: Ana
authors.initials: A
authors.lastname: Prinz
mesh_terms: D000368:Aged; D002386:Cataract / Q000209:etiology*; D004311:Double-Blind Method; D005355:Fibrosis / Q000517:prevention & control; D005500:Follow-Up Studies; D006801:Humans; D053685:Laser Therapy; D007903:Lens Capsule, Crystalline / Q000473:pathology* / Q000601:surgery; D019654:Lens Implantation, Intraocular; D007910:Lenses, Intraocular; D018918:Phacoemulsification; D011183:Postoperative Complications; D011446:Prospective Studies; D011474:Prosthesis Design; D012826:Silicone Elastomers
chemical_list: D012826:Silicone Elastomers