Micellar solubilization of selected non-steroidal therapeutic agents by new surface-active agents of the class of the products of oxyethylation of ursodeoxycholic acid.
A new class of non-ionic surface-active agents were synthesized by means of oxyethylation of ursodeoxycholic acid (UDOCh acid) with the application of modified generation of catalysts in the form of a model prodrug. Basic viscosity values ([eta], Meta, Ro, Robs., Omga) as well as the analytic level of hyrohilic-lipophilic balance HLB in the notation of Griffin, Davies and 'HNMR method were determined. In the state of equilibrium the solubilizing properties of aqueous solutions of the products of oxyetyenation of UDOCh acid x nTE were estimated with respect to non-steroidal therapeutic agents such as diclofenac, ibuprofen, ketoprofen, and naproxen. The surface activity of solubilizers of UDOCh acid > or = nTE = 30 type and the thermodynamic stability deltaGm of an adduct emerging in the state of equilibrium were determined.
Zgoda
Marian Mikołaj
MM
Drug Form Technology Unit, Department of Applied Pharmacy, Medical University in łódź. mmzgoda@pharm.am.lodz.pl
Lukosek
Marek
M
Nachajski
Michał Jakub
MJ
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry*; D004008:Diclofenac / Q000737:chemistry; D007052:Ibuprofen / Q000737:chemistry; D007660:Ketoprofen / Q000737:chemistry; D008823:Micelles; D009288:Naproxen / Q000737:chemistry; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D012995:Solubility; D012996:Solutions / Q000737:chemistry*; D013501:Surface-Active Agents / Q000737:chemistry*; D014580:Ursodeoxycholic Acid / Q000031:analogs & derivatives* / Q000737:chemistry*; D014783:Viscosity
D000894:Anti-Inflammatory Agents, Non-Steroidal; D008823:Micelles; D004364:Pharmaceutical Preparations; D012996:Solutions; D013501:Surface-Active Agents; D004008:Diclofenac; D009288:Naproxen; D014580:Ursodeoxycholic Acid; D007660:Ketoprofen; D007052:Ibuprofen