Back to the future of oridonin: again, compound from medicinal herb shows potent antileukemia efficacies in vitro and in vivo.
Zhou
Guang-Biao
GB
State Key Laboratory of Medical Genomics and Shanghai Institute of Hematology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 197 Ruijin Road II, Shanghai 200025, China.
Chen
Sai-Juan
SJ
Wang
Zhen-Yi
ZY
Chen
Zhu
Z
D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D002453:Cell Cycle / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D050676:Core Binding Factor Alpha 2 Subunit / Q000235:genetics / Q000378:metabolism; D004224:Diterpenes / Q000494:pharmacology*; D045786:Diterpenes, Kaurane / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology; D006801:Humans; D037602:Isodon / Q000737:chemistry*; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy*; D053078:Membrane Potential, Mitochondrial / Q000187:drug effects; D015514:Oncogene Proteins, Fusion / Q000235:genetics / Q000378:metabolism; D000075142:RUNX1 Translocation Partner 1 Protein; D014407:Tumor Cells, Cultured
C107844:AML1-ETO fusion protein, human; D000972:Antineoplastic Agents, Phytogenic; D050676:Core Binding Factor Alpha 2 Subunit; D004224:Diterpenes; D045786:Diterpenes, Kaurane; D004365:Drugs, Chinese Herbal; D015514:Oncogene Proteins, Fusion; D000075142:RUNX1 Translocation Partner 1 Protein; C011959:oridonin