title: [Free radicals in Carassius auratus liver: their generation and oxidative stress induced by 2,4,6-trichlorophenol].
abstract: With electron paramagnetic resonance (EPR) technique, this paper studied the free radicals generation and oxidative stress in Carassius auratus liver after 4, 8, 12, 24 and 72 hours of 2, 4,6-trichlorophenol (2,4,6-TCP) intraperitoneal injection. The results showed that 2,4,6-TCP significantly promoted the generation of free radicals in C. auratus liver. The superoxide dismutase (SOD) and glutathione-S-transferase (GST) activities were induced significantly, while catalase (CAT) activity was inhibited, and glutathione (GSH) content had little difference with the control. A significant increase was observed in the contents of oxidized glutathione (GSSG) and malondialdehyde (MDA).
authors.affiliation: School of Resources and Environment, Liaoning University, Shenyang 110036, China. jiliangliang82@163.com
authors.forename: Liang-liang
authors.initials: LL
authors.lastname: Ji
authors.forename: Fa-yun
authors.initials: FY
authors.lastname: Li
authors.forename: Yi
authors.initials: Y
authors.lastname: Luo
authors.forename: Xi-ping
authors.initials: XP
authors.lastname: Ma
authors.forename: Zhong-lin
authors.initials: ZL
authors.lastname: Chen
mesh_terms: D000818:Animals; D002374:Catalase / Q000378:metabolism; D002733:Chlorophenols / Q000633:toxicity*; D004578:Electron Spin Resonance Spectroscopy; D005982:Glutathione Transferase / Q000378:metabolism; D006054:Goldfish / Q000378:metabolism*; D008099:Liver / Q000201:enzymology*; D018384:Oxidative Stress / Q000187:drug effects*; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D002733:Chlorophenols; D002374:Catalase; D013482:Superoxide Dismutase; D005982:Glutathione Transferase; C024564:2,4,6-trichlorophenol