title: Monocytosis is an adverse prognostic factor for survival in younger patients with primary myelofibrosis.
abstract: We recently developed a modified Dupriez prognostic scoring system (PSS) that effectively discriminated between high-, intermediate-, and low-risk young patients (age < or =60 years) with primary myelofibrosis (PMF) based on the respective presence of none, one, or two or more of the following parameters: hemoglobin <10 g/dL, leukocyte count <4 or >30 x 10(9)L(-1), and platelet count <100 x 10(9)L(-1). The current study (n=129; median age, 52 years; 69 males) reveals, on multivariable analysis, that an absolute monocyte count of > or =1 x 10(9)L(-1) carries an independent predictive value (p=0.02), for an inferior survival, in addition to that provided by hemoglobin level (p=0.002), platelet count (0.02), and leukocyte count (p=0.16). The inclusion of the monocyte count as a fourth risk factor enabled the construction of a new and improved Mayo PSS; median survival was 173, 61, and 26 months in the absence of all four (low-risk), three (intermediate-risk), or two or less (high-risk) adverse features, respectively (p<0.0001). The independent prognostic value of monocytosis was validated in a separate database of 97 patients with PMF from another institution.
authors.affiliation: Department of Internal Medicine, Division of Hematology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.
authors.forename: M A
authors.initials: MA
authors.lastname: Elliott
authors.forename: S
authors.initials: S
authors.lastname: Verstovsek
authors.forename: D
authors.initials: D
authors.lastname: Dingli
authors.forename: S M
authors.initials: SM
authors.lastname: Schwager
authors.forename: R A
authors.initials: RA
authors.lastname: Mesa
authors.forename: C Y
authors.initials: CY
authors.lastname: Li
authors.forename: A
authors.initials: A
authors.lastname: Tefferi
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000473:pathology*; D055728:Primary Myelofibrosis / Q000473:pathology*; D011379:Prognosis