Survival of Proteus mirabilis O3 (S1959), O9 and O18 strains in normal human serum (NHS) correlates with the diversity of their outer membrane proteins (OMPs).
Urinary tract infections are frequently caused by Proteus mirabilis strains. In the previous studies there were defined the complete structures of O-polysaccharide parts of lipopolysaccharides from strains: P. mirabilis O3 (S1959), P. mirabilis O9 and P. mirabilis O18. In the present study it was investigated bactericidal effect of normal human serum (NHS) to P. mirabilis strains. We also focused on the diversity of outer membrane proteins (OMPs) being separated on a gel isolated from tested strains. Serial passage of P. mirabilis O18 in 90% normal bovine serum (NBS) contributed to over-expressing some classes of OMPs.
Futoma-Kołoch
Bozena
B
Institute of Genetics and Microbiology, Wrocław University, Przybyszewskiego 63/77, 51-148 Wrocław, Poland.
Bugla-Płoskońska
Gabriela
G
Doroszkiewicz
Wlodzimierz
W
Kaca
Wiesław
W
D001425:Bacterial Outer Membrane Proteins / Q000145:classification / Q000378:metabolism*; D001770:Blood Bactericidal Activity; D006801:Humans; D008070:Lipopolysaccharides / Q000378:metabolism; D011513:Proteus mirabilis / Q000276:immunology / Q000378:metabolism*; D015610:Serum Bactericidal Test; D014552:Urinary Tract Infections / Q000382:microbiology
D001425:Bacterial Outer Membrane Proteins; D008070:Lipopolysaccharides