alpha-Cyclodextrin/oil beads: an innovative self-assembling system.
The aim of this work was to characterise a new type of particulate system, named beads, prepared by a straightforward technique starting from a mixture of alpha-cyclodextrin aqueous solution and soybean oil without the use of any organic solvent or surface-active agent. Mechanisms involved in bead formation were also investigated. Optimal ratio between alpha-cyclodextrin (6%, w/w), soybean oil (19.6%, w/w) and water (74.4%, w/w) led to homogeneous bead size (1.6 mm) with a fabrication yield superior to 80% after a continuous external shaking during 2.5 days. After freeze-drying, oil and alpha-cyclodextrin contents were estimated at 80% (w/w) and 20% (w/w), respectively. X-ray diffraction studies revealed that beads presented a crystalline organisation and microscopic techniques showed that their inner structure was constituted by a matrix containing oily compartments. Beads offer interesting prospects for the microencapsulation of lipophilic and poorly stable molecules. Due to their semi-solid consistency and their ability to be freeze-dried, these beads have great potentialities for pharmaceutical (oral and topical routes) and cosmetic applications.
Bochot
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Univ Paris-Sud; CNRS UMR8612; Physico-chimie - Pharmacotechnie - Biopharmacie, Faculté de Pharmacie, 5 rue JB Clément, Châtenay-Malabry F-92296, France. amelie.bochot@u-psud.fr
Trichard
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Le Bas
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Alphandary
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Grossiord
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Duchêne
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Fattal
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D016503:Drug Delivery Systems; D013024:Soybean Oil / Q000737:chemistry*; D014783:Viscosity; D014961:X-Ray Diffraction; D047391:alpha-Cyclodextrins / Q000737:chemistry*
D047391:alpha-Cyclodextrins; D013024:Soybean Oil; C032613:alpha-cyclodextrin