Central nervous system involvement in Hodgkin's lymphoma associated with Epstein-Barr virus in a patient with AIDS: case report and review of the literature.
Intracranial and intraspinal involvement is a rare complication of Hodgkin's disease. We report a case of a patient with diagnosis of AIDS and Hodgkin's lymphoma who developed brain and spinal involvement at the time of the relapse of the neoplasm disease. Mixed cellularity histology was the subtype of Hodgkin's disease in our patient; we identified the Epstein-Barr virus genome in the Reed-Sternberg cells by immunohistochemistry and in situ hybridization.
Corti
Marcelo
M
Division of HIV/AIDS, Neurosurgery and Histopathology Laboratory, Infectious Diseases FJ Muñiz Hospital and Histopathology Laboratory, National Academy of Medicine, Buenos Aires, Argentina. marcelocorti@fibertel.com.ar
Fioti
María F Villafañe
MF
Yampolsky
Claudio
C
Schtirbu
Ricardo
R
Narbaitz
Marina
M
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D016543:Central Nervous System Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D020031:Epstein-Barr Virus Infections / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D017809:Fatal Outcome; D006689:Hodgkin Disease / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D008279:Magnetic Resonance Imaging; D008297:Male; D016539:Reed-Sternberg Cells / Q000821:virology; D014057:Tomography, X-Ray Computed