[Effect of corticosterone and plasma lipoproteins on working capacity and ultrastructure of isolated rat heart].
Blood lipoproteins (very low density--VLDL, low density--LDL and high density--HDL) penetrate into the myocardium through capillary endothelial layer via receptor mediated endocytosis (all lipoproteins), nonreceptor uptake, or along interendothelial gaps (LDL). In the myocardium lipoproteins are captured by interstitial macrophages and are subjected to degradation in secondary liposomes. Their action on myocardium results in development of perivascular swelling and constriction of substantial portion of capillaries. However part of capillaries (about 20%) stay in a condition of vasodilation. Destructive changes revealed (myelin figures, mild lysis of myofibrils) are presumably caused by activation of lysosomal proteinases. Corticosterone lowered coronary flow velocity, while parameters of working capacity of the heart remained at control level. Combined use of corticosterone and VLDL suppressed myocardial functional activity, to a great extent because of diminishment of coronary flow velocity. Corticosterone and LDL exerted less pronounced negative effect. Corticosterone and HDL caused improvement of parameters of cardiac working capacity.
Panin
L E
LE
Kolpakov
A R
AR
Maksimov
V F
VF
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000493:pharmacokinetics; D001783:Blood Flow Velocity / Q000187:drug effects; D003326:Coronary Circulation / Q000187:drug effects*; D003331:Coronary Vessels / Q000187:drug effects / Q000502:physiology / Q000648:ultrastructure; D003345:Corticosterone / Q000493:pharmacokinetics*; D006321:Heart / Q000187:drug effects* / Q000502:physiology; D008075:Lipoproteins, HDL / Q000378:metabolism / Q000494:pharmacology*; D008077:Lipoproteins, LDL / Q000493:pharmacokinetics*; D008079:Lipoproteins, VLDL / Q000493:pharmacokinetics*; D008297:Male; D008854:Microscopy, Electron; D009206:Myocardium / Q000648:ultrastructure*; D051381:Rats; D017208:Rats, Wistar; D014664:Vasodilation / Q000187:drug effects
D000893:Anti-Inflammatory Agents; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D008079:Lipoproteins, VLDL; D003345:Corticosterone