[Changes of heme oxygenase-1 and inflammatory factors in patients with end-stage renal failure following hemodialysis].
OBJECTIVE
To evaluate the changes in heme oxygenase-1 (HO-1), C-reactive protein (CRP), interleukin-6 (IL-6), and malondialdehyde (MDA) levels in patients with end-stage renal failure (ESRF) following hemodialysis.


METHODS
The urea nitrogen and the blood creatinine levels were determined with an automatic biochemistry analyzer, HO-1 and IL-6 levels by enzyme linked immunosorbent assay (ELISA), CRP by chemoluminescence technique, and MDA by thiobarbituric acid assay.


RESULTS
HO-1, CRP, IL-6, and MDA levels were significantly elevated in patients with ESRF in comparison with the control group. After hemodialysis, HO-1 and CRP levels increased and IL-6 and MDA levels decreased significantly.


CONCLUSIONS
In ESRF patients who have elevated inflammatory factors and HO-1 levels, hemodialysis can increase HO-1 and CRP levels and lower IL-6 and MDA levels.
Wu
Fan
F
Southern Medical University, Guangzhou 510515, China. fanwu112@163.com
Yu
Lu
L
Zhang
Zhi-min
ZM
Shi
Hai-bin
HB
D000328:Adult; D001806:Blood Urea Nitrogen; D002097:C-Reactive Protein / Q000378:metabolism*; D003404:Creatinine / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D051547:Heme Oxygenase-1 / Q000097:blood*; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D007676:Kidney Failure, Chronic / Q000097:blood / Q000628:therapy*; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D006435:Renal Dialysis
D015850:Interleukin-6; D008315:Malondialdehyde; D002097:C-Reactive Protein; D003404:Creatinine; D051547:Heme Oxygenase-1