title: Morphological and immunological analysis of the oral mucosa in tobacco smoking and odontopreparation.
abstract: Tobacco smoking causes pronounced structural reorganization of the gingival mucosa and its atrophic changes. Odontopreparation stimulates destructive processes in the gingival mucosa promoting activation of local immunity (stimulation of immunoglobulin synthesis). Significant differences in the local humoral immunity (IgG dysimmunoglobulinemia) and cytokine spectrum in nonsmoking and tobacco-smoking patients were detected. Subcompensated level of immune resistance in tobacco smokers prompts referring them to a group at a high risk of chronic pathological processes of the oral cavity.
authors.affiliation: Department of Cellular Biology and Morphology, Institute of Regional Pathology and Pathomorphology, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk.
authors.forename: A V
authors.initials: AV
authors.lastname: Shcheglov
authors.forename: G I
authors.initials: GI
authors.lastname: Oskol'skii
authors.forename: E L
authors.initials: EL
authors.lastname: Lushnikova
authors.forename: L M
authors.initials: LM
authors.lastname: Nepomnyashchikh
mesh_terms: D000328:Adult; D000917:Antibody Formation; D016207:Cytokines / Q000378:metabolism; D006801:Humans; D007071:Immunoglobulin A, Secretory / Q000378:metabolism; D007074:Immunoglobulin G / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000276:immunology* / Q000473:pathology*; D009971:Orthodontics, Corrective / Q000379:methods; D012907:Smoking / Q000276:immunology* / Q000473:pathology*
chemical_list: D016207:Cytokines; D007071:Immunoglobulin A, Secretory; D007074:Immunoglobulin G