Vertebral polyostotic lymphoma in a young dog.
An unusual clinical presentation of lymphoma with vertebral involvement in a dog is reported. A 20-month-old intact female Golden Retriever presented with progressive paraparesis and anorexia. Complete blood count and serum biochemistry profile demonstrated pancytopenia and hypercalcemia. Ventral fusion of the lumbar vertebrae by new bony tissue deposition was evident on X-ray and CT scan. Fine needle aspiration revealed neoplastic lymphoid cells in lymph nodes and bone marrow. Histologically, vertebral bone and osteophytes, liver, bone marrow, kidney, and lymph nodes were diffusely infiltrated by neoplastic, lymphoid cells, with scant cytoplasm and round hyperchromatic nuclei. Polyostotic and medullary T-cell lymphoma with spondylosis was diagnosed. Lymphoma mainly affecting bone is uncommon in the dog. The present case differs from previously described polyostotic lymphomas in clinical signs of the disease, mainly attributable to spondylarthrosis. In addition, lymphomatous proliferation was associated with osteoproductive lesions of the vertebrae.
Vascellari
Marta
M
Histopathology Department, Istituto Zooprofilattico Sperimentale delle Venezie, 35020 Legnaro (PD), Italy. mvascellari@izsvenezie.it
Tasca
Silvia
S
Furlanello
Tommaso
T
Carli
Erika
E
Patron
Carlo
C
Mutinelli
Franco
F
Caldin
Marco
M
D000818:Animals; D000855:Anorexia / Q000209:etiology / Q000662:veterinary; D044963:Biopsy, Fine-Needle / Q000662:veterinary; D001853:Bone Marrow / Q000473:pathology; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D005260:Female; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging / Q000473:pathology; D008223:Lymphoma / Q000473:pathology / Q000662:veterinary*; D020335:Paraparesis / Q000209:etiology / Q000662:veterinary; D011859:Radiography; D013125:Spinal Neoplasms / Q000473:pathology / Q000662:veterinary*