Mechanisms of hemolytic anemia during experimental methemoglobinemias.
A complex study of the peripheral erythron component was performed during methemoglobinemias induced by single administration of sodium nitrate and phenylhydrazine in LD50. Administration of methemoglobin-forming agents to rats induced the development of hemolytic anemia. The pathogenesis of this disorder included significant long-term modifications of the erythrocyte membrane. The severity and duration of anemia syndrome depended on chemical structure of xenobiotics, blood methemoglobin level, and the duration of the acute period of methemoglobinemia.
Novitskii
V V
VV
Siberian State Medical University, Federal Agency of Public Health and Social Development, Tomsk.
Ryazantseva
N V
NV
Shperling
I A
IA
Filippova
O N
ON
Rogov
O A
OA
D000743:Anemia, Hemolytic / Q000209:etiology*; D000818:Animals; D002784:Cholesterol / Q000097:blood; D004910:Erythrocyte Membrane / Q000737:chemistry; D008297:Male; D008708:Methemoglobinemia / Q000139:chemically induced / Q000150:complications*; D009566:Nitrates; D010659:Phenylhydrazines; D010743:Phospholipids / Q000097:blood; D051381:Rats; D017208:Rats, Wistar; D000254:Sodium-Potassium-Exchanging ATPase / Q000097:blood
D009566:Nitrates; D010659:Phenylhydrazines; D010743:Phospholipids; C030299:phenylhydrazine; C031618:sodium nitrate; D002784:Cholesterol; D000254:Sodium-Potassium-Exchanging ATPase