title: Facile synthesis of (+/-)-paeonilide.
abstract: (+/-)-Paeonilide, a novel monoterpenoid metabolite from the roots of Paeonia delavayi showing anti-platelet activating factor activity, is convergently synthesized in five steps with 59% overall yield. The application of benzoyl peroxide-promoted radical addition of unsaturated ester to aldehyde and subsequent topologically favored cyclization greatly simplified the synthesis.
authors.affiliation: State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China. duyuguo@rcees.ac.cn
authors.forename: Yuguo
authors.initials: Y
authors.lastname: Du
authors.forename: Jun
authors.initials: J
authors.lastname: Liu
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Linhardt
mesh_terms: D005663:Furans / Q000737:chemistry*; D015394:Molecular Structure; D013729:Terpenes / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D005663:Furans; D013729:Terpenes; C416702:paeonilide