A metastatic melanoma with an unusual immunophenotypic profile.
The most commonly used melanocytic markers are S100, HMB45, Melan-A, or MART-1 and tyrosinase. Melanoma with complete, concordant loss of these markers has not been reported. We report a case of metastatic melanoma with complete loss of staining for S100, HMB45, Melan-A, and tyrosinase. Interestingly, both the primary melanoma and its metastasis were strongly positive for CD99.
Gao
Zhenqiang
Z
Department of Pathology, Albert Einstein College of Medicine North Shore Long Island Jewish Health System, New Hyde Park, NY 11040, USA.
Stanek
Albert
A
Chen
Sheng
S
D000071443:12E7 Antigen; D000368:Aged; D015703:Antigens, CD / Q000032:analysis; D000951:Antigens, Neoplasm / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis*; D019002:CD56 Antigen / Q000032:analysis; D015815:Cell Adhesion Molecules / Q000032:analysis; D015536:Down-Regulation; D006801:Humans; D007150:Immunohistochemistry; D016130:Immunophenotyping; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis; D058965:MART-1 Antigen; D008297:Male; D008545:Melanoma / Q000737:chemistry* / Q000175:diagnosis / Q000201:enzymology / Q000276:immunology / Q000473:pathology; D058950:Melanoma-Specific Antigens; D014442:Monophenol Monooxygenase / Q000032:analysis; D009363:Neoplasm Proteins / Q000032:analysis; D009418:S100 Proteins / Q000032:analysis; D012878:Skin Neoplasms / Q000737:chemistry* / Q000175:diagnosis / Q000201:enzymology / Q000276:immunology / Q000473:pathology; D014746:Vimentin / Q000032:analysis
D000071443:12E7 Antigen; D015703:Antigens, CD; D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D019002:CD56 Antigen; C061828:CD99 protein, human; D015815:Cell Adhesion Molecules; D058965:MART-1 Antigen; C548667:MLANA protein, human; D058950:Melanoma-Specific Antigens; D009363:Neoplasm Proteins; D009418:S100 Proteins; D014746:Vimentin; D014442:Monophenol Monooxygenase