title: Attenuated aerobic exercise capacity in CD36 deficiency.
abstract: BACKGROUND
  An important role of CD36 in muscle fatty acid (FA) uptake has been shown in CD36-knockout or CD36-overexpressed mice. FA is a predominant substrate in energy production during light exercise below the anaerobic threshold (AT). We studied whether aerobic exercise capacity in humans could be affected by CD36 deficiency.
  
  
  METHODS
  We investigated the ventilatory threshold (VT) and serum FA changes in normal participants (n = 22) and participants with CD36 deficiency (n = 12) during pedalling on a cycle ergometer.
  
  
  RESULTS
  In participants with CD36 deficiency, FA levels were not reduced at peak work rate, whereas FA levels decreased by about 50% in normal participants. Participants with CD36 deficiency showed significantly lower VT than normal participants. A significant correlation was observed between VT and percentage changes in FA at peak work rate.
  
  
  CONCLUSIONS
  This study found reduced FA utilisation and an attenuated aerobic exercise capacity in CD36 deficiency, indicating that CD36-mediated FA oxidation is an important determinant for aerobic exercise capacity in humans.
authors.affiliation: Department of Laboratory Medicine, Hokkaido University School of Medicine, Sapporo 060-8648, Japan. yanaih@jikei.ac.jp
authors.forename: Hidekatsu
authors.initials: H
authors.lastname: Yanai
authors.forename: Ichiro
authors.initials: I
authors.lastname: Watanabe
authors.forename: Kojiro
authors.initials: K
authors.lastname: Ishii
authors.forename: Mie
authors.initials: M
authors.lastname: Morimoto
authors.forename: Hironobu
authors.initials: H
authors.lastname: Fujiwara
authors.forename: Shigeru
authors.initials: S
authors.lastname: Yoshida
authors.forename: Shu-Ping
authors.initials: SP
authors.lastname: Hui
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Matsuno
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Chiba
mesh_terms: D000328:Adult; D015308:Anaerobic Threshold / Q000235:genetics* / Q000502:physiology; D018955:CD36 Antigens / Q000235:genetics*; D005080:Exercise Test; D005227:Fatty Acids / Q000097:blood; D005260:Female; D005838:Genotype; D006801:Humans; D007564:Japan; D010084:Oxidation-Reduction; D012123:Pulmonary Ventilation
chemical_list: D018955:CD36 Antigens; D005227:Fatty Acids