Worldwide variation in the relative importance of hepatitis B and hepatitis C viruses in hepatocellular carcinoma: a systematic review.
We combined information published worldwide on the seroprevalence of hepatitis B surface antigen (HbsAg) and antibodies against hepatitis C virus (anti-HCV) in 27 881 hepatocellular carcinomas (HCCs) from 90 studies. A predominance of HBsAg was found in HCCs from most Asian, African and Latin American countries, but anti-HCV predominated in Japan, Pakistan, Mongolia and Egypt. Anti-HCV was found more often than HBsAg in Europe and the United States.
Raza
S A
SA
Department of Surgery, The Aga Khan University, Stadium Road, PO Box 3500, Karachi 74800, Pakistan.
Clifford
G M
GM
Franceschi
S
S
D006528:Carcinoma, Hepatocellular / Q000453:epidemiology / Q000276:immunology / Q000821:virology*; D014943:Global Health; D016174:Hepacivirus / Q000276:immunology*; D006509:Hepatitis B / Q000453:epidemiology / Q000276:immunology*; D006514:Hepatitis B Surface Antigens / Q000097:blood; D006515:Hepatitis B virus / Q000276:immunology*; D006526:Hepatitis C / Q000453:epidemiology / Q000276:immunology*; D018937:Hepatitis C Antibodies / Q000097:blood; D006801:Humans; D008113:Liver Neoplasms / Q000453:epidemiology / Q000276:immunology / Q000821:virology*; D016036:Seroepidemiologic Studies
D006514:Hepatitis B Surface Antigens; D018937:Hepatitis C Antibodies