title: [Durability of aortic root preservation using gelatin-resorcin-formalin glue in acute type A aortic dissection].
abstract: During the last 9 years, aortic root preservation using gelatin-resorcin-formalin (GRF) glue was performed in 63 patients as a part of surgery for acute type A aortic dissection. Residual aortic regurgitation (AR) was evaluated, grading 0 to IV+ by echocardiography. The survival and root reoperation-free rates were also assessed. The operative mortality was 9.5% (6 patients). Early postoperative AR < or = I+, = II+ and > or =III+ were 93, 7 and 0%, respectively. Late postoperative AR > or =III+ was observed in 4 patients. Root reoperation was performed in 4 patients (7.0%). In a case of reoperation, medial degeneration was found in the aortic wall, suggesting toxic effect of GRF glue. The actuarial survival and root reoperation-free rates at 9 years were 73 and 80%, respectively. In conclusion, aortic root preservation with the proper use of GRF glue has long-term durability with very low adverse effect.
authors.affiliation: Department of Cardiovascular Surgery, Niigata City Hospital, Niigata, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Aoki
authors.forename: S
authors.initials: S
authors.lastname: Nakazawa
authors.forename: Y
authors.initials: Y
authors.lastname: Takahashi
authors.forename: H
authors.initials: H
authors.lastname: Kanazawa
authors.forename: Y
authors.initials: Y
authors.lastname: Yamazaki
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000784:Aortic Dissection / Q000401:mortality / Q000601:surgery*; D001011:Aorta; D001014:Aortic Aneurysm / Q000401:mortality / Q000601:surgery*; D017545:Aortic Aneurysm, Thoracic / Q000401:mortality / Q000601:surgery*; D001022:Aortic Valve Insufficiency / Q000150:complications / Q000601:surgery*; D019917:Blood Vessel Prosthesis Implantation; D004338:Drug Combinations; D005260:Female; D005557:Formaldehyde / Q000008:administration & dosage* / Q000009:adverse effects; D005780:Gelatin / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D012118:Resorcinols / Q000008:administration & dosage* / Q000009:adverse effects; D015996:Survival Rate
chemical_list: D004338:Drug Combinations; D012118:Resorcinols; C027813:gelatin-resorcinol-formaldehyde tissue adhesive; D005557:Formaldehyde; D005780:Gelatin