title: Repeated measurements of learned irrelevance by a novel within-subject paradigm in humans.
abstract: Learned irrelevance (LIrr) refers to the retardation of classical conditioning following preexposure of the to-be-associated stimuli. Healthy volunteers have been tested on three occasions with a new LIrr paradigm avoiding methodological problems which afflict traditional paradigms. A significant LIrr effect was demonstrated on each occasion. Thus, the new paradigm enables repeated measurements of LIrr and might be useful in evaluating long-term effects of medication in psychiatric disorders exhibiting aberrant LIrr.
authors.affiliation: Laboratory of Behavioral Biology, ETH Zürich, Switzerland.ariane.orosz@insel.ch
authors.forename: Ariane
authors.initials: A
authors.lastname: Orosz
authors.forename: Joram
authors.initials: J
authors.lastname: Feldon
authors.forename: Gilad
authors.initials: G
authors.lastname: Gal
authors.forename: Andor
authors.initials: A
authors.lastname: Simon
authors.forename: Katja
authors.initials: K
authors.lastname: Cattapan-Ludewig
mesh_terms: D000328:Adult; D001245:Association Learning; D001288:Attention; D035841:Behavioral Research / Q000379:methods*; D003214:Conditioning, Classical; D023381:Endpoint Determination; D005260:Female; D005364:Field Dependence-Independence; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000188:drug therapy; D010364:Pattern Recognition, Visual; D012016:Reference Values; D015203:Reproducibility of Results