title: Satoyoshi syndrome has antibody against brain and gastrointestinal tissue.
abstract: Satoyoshi syndrome is a rare postnatal disorder with muscle spasms, alopecia, and diarrhea of unknown etiology. Nutritional deficiency seems to influence lifespan. We present a patient with this syndrome having a unique "mesh-like" mucosal change radiographically and white granules endoscopically in the gastrointestinal tract. A common antibody against brain, stomach, and duodenal tissue, according to Western blot analysis, was detected in the sera of two patients with this syndrome. These findings suggest that Satoyoshi syndrome is a systemic autoimmune disease involving the nervous, endocrine, and gastrointestinal systems.
authors.affiliation: Department of Neurology and Geriatrics, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan.
authors.forename: Eiji
authors.initials: E
authors.lastname: Matsuura
authors.forename: Wataru
authors.initials: W
authors.lastname: Matsuyama
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Sameshima
authors.forename: Kimiyoshi
authors.initials: K
authors.lastname: Arimura
mesh_terms: D000293:Adolescent; D000505:Alopecia / Q000175:diagnosis / Q000276:immunology* / Q000473:pathology; D001323:Autoantibodies / Q000097:blood*; D001327:Autoimmune Diseases / Q000175:diagnosis / Q000276:immunology* / Q000473:pathology; D001921:Brain / Q000276:immunology; D003967:Diarrhea / Q000175:diagnosis / Q000276:immunology* / Q000473:pathology; D004724:Endoscopy; D005260:Female; D005753:Gastric Mucosa / Q000276:immunology / Q000473:pathology; D006801:Humans; D013035:Spasm / Q000175:diagnosis / Q000276:immunology*; D013270:Stomach / Q000276:immunology; D013577:Syndrome
chemical_list: D001323:Autoantibodies