Collagen antibody-induced arthritis.
Collagen antibody-induced arthritis (CAIA) is a simple mouse model of rheumatoid arthritis that can be used to address questions of pathogenic mechanisms and to screen candidate therapeutic agents. Arthritis is stimulated by the administration of a cocktail of monoclonal antibodies that are directed to conserved auto-antigenic epitopes in collagen type II, followed by endotoxin. The antibody-induced arthritis model offers several key advantages over the classic collagen-induced arthritis (CIA) model. These include rapid disease onset, high uptake rate, synchronicity, and the capacity to use genetically modified mice, such as transgenics and knockouts. This protocol takes 1-2 weeks to be completed.
Khachigian
Levon M
LM
Centre for Vascular Research, Department of Pathology, School of Medical Sciences, The University of New South Wales, Sydney, NSW 2052, Australia. L.Khachigian@unsw.edu.au
D000818:Animals; D000911:Antibodies, Monoclonal; D001172:Arthritis, Rheumatoid / Q000276:immunology* / Q000473:pathology; D024043:Collagen Type II / Q000276:immunology*; D004195:Disease Models, Animal; D005121:Extremities / Q000473:pathology; D051379:Mice / Q000276:immunology*
D000911:Antibodies, Monoclonal; D024043:Collagen Type II