Urokinase induces ROS production in vascular smooth muscle cells.
Urokinase stimulates the production of superoxide radical in cultured aortal smooth muscle cells simultaneously with activation of the expression of NAD(F)H-oxidases nox1, nox4, and phox22. Antioxidant ebselen abolishes the stimulating effect of urokinase on smooth muscle cell proliferation. The data showed that urokinase can potentiate oxidative stress in the arterial wall and can play an important role in the development of adverse arterial remodeling.
Plekhanova
O S
OS
Russian Cardiology Research-and-Production Complex, Ministry of Health, Moscow.
Men'shikov
M Yu
MY
Bashtrykov
P P
PP
Berk
B C
BC
Tkachuk
V A
VA
Parfenova
E V
EV
D000818:Animals; D001011:Aorta / Q000166:cytology; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D008163:Luminescent Measurements; D008297:Male; D009130:Muscle, Smooth / Q000187:drug effects*; D009131:Muscle, Smooth, Vascular / Q000166:cytology; D009247:NADH, NADPH Oxidoreductases / Q000378:metabolism; D000074624:NADPH Oxidase 1; D000074663:NADPH Oxidase 4; D019255:NADPH Oxidases / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D017382:Reactive Oxygen Species / Q000378:metabolism*; D011994:Recombinant Proteins / Q000494:pharmacology; D013481:Superoxides / Q000378:metabolism; D014568:Urokinase-Type Plasminogen Activator / Q000235:genetics / Q000494:pharmacology*
D017382:Reactive Oxygen Species; D011994:Recombinant Proteins; D013481:Superoxides; D009247:NADH, NADPH Oxidoreductases; D000074624:NADPH Oxidase 1; D000074663:NADPH Oxidase 4; D019255:NADPH Oxidases; C000614712:NOX1 protein, rat; C498911:Nox4 protein, rat; D014568:Urokinase-Type Plasminogen Activator