Mitochondrial redistribution: adding new players to the chemotaxis game.
Leukocyte polarization and chemotaxis have a key role in the homeostasis of the immune system and in inflammation. Recent work shows that chemoattractants induce the redistribution of mitochondria towards the uropod of polarized migrating leukocytes through a mechanism involving microtubules and mitochondrial fission. These findings underscore the key role this organelle can have in leukocyte chemotaxis by fuelling motor proteins at their trailing edge.
Sánchez-Madrid
Francisco
F
Departamento de Biología Vascular e Inflamación, Centro Nacional de Investigaciones Cardiovasculares, 28029 Madrid, Spain. fsanchez.hlpr@salud.madrid.org
Serrador
Juan M
JM
D000818:Animals; D002465:Cell Movement; D016764:Cell Polarity; D002630:Chemotactic Factors / Q000494:pharmacology*; D002634:Chemotaxis, Leukocyte / Q000502:physiology*; D004023:Dictyostelium / Q000502:physiology / Q000648:ultrastructure; D018922:HL-60 Cells; D006801:Humans; D007962:Leukocytes / Q000187:drug effects / Q000378:metabolism / Q000502:physiology* / Q000648:ultrastructure; D018613:Microscopy, Confocal; D008870:Microtubules / Q000187:drug effects / Q000378:metabolism; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism / Q000502:physiology* / Q000648:ultrastructure; D024101:Mitochondrial Proteins / Q000235:genetics / Q000378:metabolism
D002630:Chemotactic Factors; D024101:Mitochondrial Proteins