Liposomal drug delivery.
Liposomes are composed of phospholipids, the basic components of human cell walls. Liposome encapsulation improves a medication's bioavailability, which can extend treatment effects and reduce drug dosing. The therapeutic advantages of liposomal drug delivery, such as the ability of long-circulating liposomes to accumulate preferentially at disease sites, including tumors and sites of inflammation, are well recognized. In cases in which a single active has more than one liposome product available, formulation changes leading to differences in pharmacokinetics, toxicity, and clinical efficacy are described.
Allison
S Dean
SD
Drug Delivery, University of South Carolina College of Pharmacy, Columbia, SC 29208, USA. allison@cop.sc.edu
D000666:Amphotericin B / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D016503:Drug Delivery Systems; D004496:Education, Continuing; D008081:Liposomes
D008081:Liposomes; D000666:Amphotericin B; D004317:Doxorubicin