title: Anti-angiogenic activity of the methanol extract and its fractions of Ulmus davidiana var. japonica.
abstract: This study aimed to elucidate anti-angiogenic activity of Ulmus davidiana var. japonica that has been widely used in folk medicine. The methanol extract (UDE) of Ulmus davidiana var. japonica concentration-dependently displayed a strong inhibition in the chick chorioallantoic membrane (CAM) angiogenesis. The n-butanol fraction of UDE and subsequent 30% MeOH subfraction were identified to be most responsible for the anti-angiogenic activity.
authors.affiliation: College of Pharmacy, Sookmyung Women's University, Seoul 140-742, Republic of Korea.
authors.forename: Hyun-Joo
authors.initials: HJ
authors.lastname: Jung
authors.forename: Hye-Jin
authors.initials: HJ
authors.lastname: Jeon
authors.forename: Eun-Ju
authors.initials: EJ
authors.lastname: Lim
authors.forename: Eun-Kyoung
authors.initials: EK
authors.lastname: Ahn
authors.forename: Yun Seon
authors.initials: YS
authors.lastname: Song
authors.forename: Sanghyun
authors.initials: S
authors.lastname: Lee
authors.forename: Kuk Hyun
authors.initials: KH
authors.lastname: Shin
authors.forename: Chang-Jin
authors.initials: CJ
authors.lastname: Lim
authors.forename: Eun-Hee
authors.initials: EH
authors.lastname: Park
mesh_terms: D020533:Angiogenesis Inhibitors / Q000494:pharmacology*; D000818:Animals; D002642:Chick Embryo; D049033:Chorioallantoic Membrane / Q000098:blood supply / Q000187:drug effects; D000432:Methanol; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D012039:Regional Blood Flow / Q000187:drug effects; D012997:Solvents; D034403:Ulmus / Q000737:chemistry*
chemical_list: D020533:Angiogenesis Inhibitors; D010936:Plant Extracts; D012997:Solvents; D000432:Methanol