title: Genetic relatedness of Streptococcus pneumoniae isolates from paired blood and respiratory specimens.
abstract: To assess the relatedness of Streptococcus pneumoniae isolates recovered concurrently from blood and respiratory tract specimens from patients with pneumonia, we analyzed 24 paired isolates by pulsed-field gel electrophoresis (PFGE), serotyping, and antimicrobial susceptibility testing. PFGE, serotype, and/or susceptibility patterns were identical for 22 of 24 pairs. Susceptibility results for blood isolates should guide therapy.
authors.affiliation: Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA. lizzie.harrell@duke.edu
authors.forename: L J
authors.initials: LJ
authors.lastname: Harrell
authors.forename: S K
authors.initials: SK
authors.lastname: Sharps
authors.forename: R A
authors.initials: RA
authors.lastname: Bean
authors.forename: L B
authors.initials: LB
authors.lastname: Reller
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001769:Blood / Q000382:microbiology*; D002648:Child; D002675:Child, Preschool; D004269:DNA, Bacterial / Q000032:analysis / Q000302:isolation & purification; D016521:Electrophoresis, Gel, Pulsed-Field; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D011018:Pneumonia, Pneumococcal / Q000382:microbiology*; D012137:Respiratory System / Q000382:microbiology*; D012703:Serotyping; D013296:Streptococcus pneumoniae / Q000145:classification* / Q000187:drug effects / Q000235:genetics* / Q000302:isolation & purification
chemical_list: D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial