Peculiarities of active avoidance conditioning in rats with various forms of inherited arterial hypertension.
Peculiarities of active avoidance conditioning were studied in NISAG rats (hereditary stress-induced arterial hypertension) and spontaneously hypertensive SHR rats. Conditioning was successful in 90% normotensive Wistar rats and in only 9.1% NISAG rats. Hypertensive SHR rats were intermediate between Wistar and NISAG rats by their learning capacity (66.7%). Our results suggest that differences in learning capacity of hypertensive rats are determined by genetic characteristics of animal behavior and emotional state, rather than blood pressure elevation.
Loskutova
L V
LV
Institute of Physiology, Siberian Division of the Russian Academy of Medical Sciences. loskutova@iph.ma.nsc.ru
Filatov
A V
AV
Dubrovia
N I
NI
Markel'
A L
AL
D000818:Animals; D001362:Avoidance Learning / Q000502:physiology*; D006973:Hypertension / Q000235:genetics / Q000503:physiopathology* / Q000523:psychology*; D010146:Pain / Q000503:physiopathology; D051381:Rats; D011918:Rats, Inbred SHR; D017208:Rats, Wistar; D011930:Reaction Time; D013315:Stress, Psychological