title: Stromal-cell regulation of natural killer cell differentiation.
abstract: Natural killer (NK) cells are bone-marrow-derived lymphocytes that play a crucial role in host defense against some viral and bacterial infections, as well as against tumors. Their phenotypic and functional maturation requires intimate interactions between the bone marrow stroma and committed precursors. In parallel to the identification of several phenotypic and functional stages of NK cell development, recent studies have shed new light on the role of stromal cells in driving functional maturation of NK cells. In this review, we provide an overview of the role of bone marrow microenvironment in NK cell differentiation.
authors.affiliation: Laboratoire Immunité Cellulaire Antivirale, Département d'Immunologie, Institut Pasteur, 75724, Paris Cedex 15, France. clroth@pasteur.fr
authors.forename: Claude
authors.initials: C
authors.lastname: Roth
authors.forename: Carla
authors.initials: C
authors.lastname: Rothlin
authors.forename: Sylvain
authors.initials: S
authors.lastname: Riou
authors.forename: David H
authors.initials: DH
authors.lastname: Raulet
authors.forename: Greg
authors.initials: G
authors.lastname: Lemke
mesh_terms: D000818:Animals; D018952:Antigens, CD34; D001853:Bone Marrow / Q000502:physiology; D019002:CD56 Antigen; D002454:Cell Differentiation / Q000502:physiology*; D002478:Cells, Cultured; D003602:Cytotoxicity, Immunologic; D006801:Humans; D019409:Interleukin-15; D007694:Killer Cells, Natural / Q000166:cytology* / Q000502:physiology; D051379:Mice; D015398:Signal Transduction; D013234:Stem Cells / Q000166:cytology / Q000502:physiology; D017154:Stromal Cells / Q000502:physiology*
chemical_list: D018952:Antigens, CD34; D019002:CD56 Antigen; D019409:Interleukin-15