Experimental and theoretical investigations on the adsorption of 2'-deoxyguanosine oxidation products at oxidized boron-doped diamond electrodes.
Electrochemical oxidation of 2'-deoxyguanosine has been performed on boron-doped diamond (BDD) electrodes, resulting in a strong adsorption of the formed oxidized products onto the BDD surface. The adsorption behavior has been investigated by studying the electrochemical behavior of a redox probe ([IrCl6]3-) using cyclic voltammetry. The most probable situations are the formation of (A) an insulating adsorbed film resulting in a partially blocked electrode behavior, (B) a porous film, or (C) an overall conductive film. Different parameters such as the standard rate constant, the charge-transfer coefficient, the electrode/adsorbed products/solution interface resistance, and the formal potential of the redox couple were determined. Through comparison of theoretical current-potential curves obtained by analytical calculations with experimental cyclic voltammograms, we found that the oxidized products of 2'-deoxyguanosine form a continuous conductive film on BDD.
Fortin
Elodie
E
Groupe Chimie de la Reconnaissance et Etude des Assemblages Biologiques - SprAM (UMR 5819 CEA/CNRS/UJF), DRFMC/SPrAM/CREAB, CEA Grenoble, 17 rue des Martyrs, 38054 Grenoble Cedex 9, France.
Vieil
Eric
E
Mailley
Pascal
P
Szunerits
Sabine
S
Livache
Thierry
T
D000327:Adsorption; D001895:Boron; D003849:Deoxyguanosine; D018130:Diamond; D004563:Electrochemistry / Q000295:instrumentation / Q000379:methods*; D004566:Electrodes; D010084:Oxidation-Reduction
D018130:Diamond; D003849:Deoxyguanosine; D001895:Boron