Effects of astaxanthin in obese mice fed a high-fat diet.
Astaxanthin is a natural antioxidant carotenoid that occurs in a wide variety of living organisms. We investigated the effects of astaxanthin supplementation in obese mice fed a high-fat diet. Astaxanthin inhibited the increases in body weight and weight of adipose tissue that result from feeding a high-fat diet. In addition, astaxanthin reduced liver weight, liver triglyceride, plasma triglyceride, and total cholesterol. These results suggest that astaxanthin might be of value in reducing the likelihood of obesity and metabolic syndrome in affluent societies.
Ikeuchi
Mayumi
M
Laboratory of Nertraceuticals and Functional Foods Science, Graduate School of Marine Science and Technology, Tokyo University of Marine Science and Technology, Tokyo, Japan.
Koyama
Tomoyuki
T
Takahashi
Jiro
J
Yazawa
Kazunaga
K
D000273:Adipose Tissue / Q000187:drug effects / Q000254:growth & development; D000818:Animals; D019440:Anti-Obesity Agents / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects; D002791:Cholesterol, Dietary / Q000494:pharmacology; D004032:Diet; D004041:Dietary Fats / Q000494:pharmacology*; D004435:Eating / Q000187:drug effects; D005260:Female; D050356:Lipid Metabolism / Q000187:drug effects; D008055:Lipids; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D009765:Obesity / Q000188:drug therapy*; D009929:Organ Size / Q000187:drug effects; D010101:Oxygen Consumption; D014280:Triglycerides / Q000378:metabolism; D024341:Xanthophylls / Q000494:pharmacology
D019440:Anti-Obesity Agents; D002791:Cholesterol, Dietary; D004041:Dietary Fats; D008055:Lipids; D014280:Triglycerides; D024341:Xanthophylls; C005948:astaxanthine