title: Adiponectin level and left ventricular hypertrophy in Japanese men.
abstract: A recent study has demonstrated that adiponectin inhibited hypertrophic signaling in the myocardium of mice, implying that a decrease in the blood adiponectin level could cause cardiac muscle hypertrophy. We hypothesized that a relationship might exist between the serum adiponectin level and electrocardiographically diagnosed left ventricular hypertrophy (ECG-LVH), and we examined this hypothesis by epidemiological study of 2839 Japanese male workers who were not taking medications for hypertension. ECG-LVH was defined as meeting Sokolow-Lyon voltage criteria and/or Cornell voltage-duration product. The subjects were categorized by tertiles of serum adiponectin level, and a multivariate logistic regression analysis was conducted relating left ventricular hypertrophy to adiponectin tertiles adjusting for potential confounding factors. Prevalence of ECG-LVH in the studied sample was 16.7%. Adiponectin ranged from 1.0 to 5.0 microg/mL in the lowest category and from 7.4 to 30.6 microg/mL in the highest. Compared with subjects in the highest adiponectin category, those in the lowest one had a significantly higher prevalence of ECG-LVH independent of age, body mass index, and systolic blood pressure with an odds ratio of 1.50 and a 95% CI of 1.16 to 1.94. Further adjustment for high-density lipoprotein cholesterol, triglyceride, and insulin resistance did not change the association (odds ratio: 1.68; 95% CI: 1.28 to 2.21; P<0.001). Similar results were obtained when different criteria for ECG-LVH were used or when subjects were stratified by blood pressure or body mass index. Adiponectin concentration was inversely and independently associated with ECG-LVH in Japanese men.
authors.affiliation: Department of Public Health/Health Information Dynamics, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan.
authors.forename: Hirotsugu
authors.initials: H
authors.lastname: Mitsuhashi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yatsuya
authors.forename: Koji
authors.initials: K
authors.lastname: Tamakoshi
authors.forename: Kunihiro
authors.initials: K
authors.lastname: Matsushita
authors.forename: Rei
authors.initials: R
authors.lastname: Otsuka
authors.forename: Keiko
authors.initials: K
authors.lastname: Wada
authors.forename: Kaichiro
authors.initials: K
authors.lastname: Sugiura
authors.forename: Seiko
authors.initials: S
authors.lastname: Takefuji
authors.forename: Yo
authors.initials: Y
authors.lastname: Hotta
authors.forename: Takahisa
authors.initials: T
authors.lastname: Kondo
authors.forename: Toyoaki
authors.initials: T
authors.lastname: Murohara
authors.forename: Hideaki
authors.initials: H
authors.lastname: Toyoshima
mesh_terms: D052242:Adiponectin / Q000097:blood* / Q000502:physiology; D000328:Adult; D000368:Aged; D015992:Body Mass Index; D004562:Electrocardiography; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000097:blood* / Q000453:epidemiology* / Q000503:physiopathology; D007564:Japan / Q000453:epidemiology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D015995:Prevalence
chemical_list: D052242:Adiponectin