title: CAD in clinical trials: current role and architectural requirements.
abstract: Computer-aided diagnosis (CAD) technology is becoming an important tool to assess treatment response in clinical trials. However, CAD software alone is not sufficient to conduct an imaging-based clinical trial. There are a number of architectural requirements such as image receive (from multiple field sites), a database for storing quantitative measures, and data mining and reporting capabilities. In this paper we describe the architectural requirements to incorporate CAD into clinical trials and illustrate their functionality in therapeutic trials for emphysema.
authors.affiliation: UCLA, Department of Radiological Sciences, USA. MBrown@mednet.ucla.edu
authors.forename: Matthew S
authors.initials: MS
authors.lastname: Brown
authors.forename: Michael F
authors.initials: MF
authors.lastname: McNitt-Gray
authors.forename: Richard
authors.initials: R
authors.lastname: Pais
authors.forename: Sumit K
authors.initials: SK
authors.lastname: Shah
authors.forename: Peiyuan
authors.initials: P
authors.lastname: Qing
authors.forename: Irene
authors.initials: I
authors.lastname: Da Costa
authors.forename: Denise R
authors.initials: DR
authors.lastname: Aberle
authors.forename: Jonathan G
authors.initials: JG
authors.lastname: Goldin
mesh_terms: D002986:Clinical Trials as Topic; D003199:Computer Systems; D003936:Diagnosis, Computer-Assisted / Q000706:statistics & numerical data*; D006801:Humans; D017063:Outcome Assessment, Health Care; D011656:Pulmonary Emphysema / Q000000981:diagnostic imaging / Q000628:therapy; D011859:Radiography; D014481:United States