title: Limited Wegener's granulomatosis--is it limited?
abstract: Complete heart block associated with Wegener's granulomatosis (WG) is rare especially in the limited form of the disease. We describe a case of a 43-year-old woman with a limited form of WG who developed a complete heart block. Prompt treatment with steroids and cyclophosphamide led to temporary regression of complete heart block. Further involvement of lung was treated successfully by tumor necrosis factor-alpha inhibitor infliximab. Cardiac rhythm abnormalities should always be kept in mind both in diagnosis and follow-up of WG.
authors.affiliation: Department of Internal Medicine F, Western Galilee Hospital, P.O.B 21, Nahariya, 22100, Israel.
authors.forename: Svetlana
authors.initials: S
authors.lastname: Lisitsin
authors.forename: Raymond
authors.initials: R
authors.lastname: Farah
authors.forename: Moshe
authors.initials: M
authors.lastname: Shay
mesh_terms: D000328:Adult; D000911:Antibodies, Monoclonal / Q000494:pharmacology / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D014890:Granulomatosis with Polyangiitis / Q000175:diagnosis*; D006327:Heart Block / Q000628:therapy*; D006801:Humans; D000069285:Infliximab; D008168:Lung / Q000473:pathology; D013256:Steroids / Q000494:pharmacology / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D000911:Antibodies, Monoclonal; D013256:Steroids; D014409:Tumor Necrosis Factor-alpha; D003520:Cyclophosphamide; D000069285:Infliximab