title: Metallic film optimization in a surface plasmon resonance biosensor by the extended Rouard method.
abstract: The extended Rouard method is applied to the computation of a multi-absorbing-layer system for the optimization of surface plasmon resonance (SPR) sensors. Specifically, the effect of the properties of a metallic layer on the shape of the reflectivity and sensitivity curve is demonstrated in the case of a Kretschmann configuration. This theoretical investigation allows us to establish the best optical properties of the metal to obtain a localized SPR, given the illuminating beam properties. Toward the development of a sensitive biosensor based on SPR, we quantify the changes in reflectivity of such an optical biosensor induced by the deposition of a nanometric biochemical film as a function of the metal film characteristics and the illumination operating conditions. The sensitivity of the system emphasizes the potential of such biophotonic technology using metallic multilayer configurations, especially with envisioned metamaterials.
authors.affiliation: Laboratoire Charles Fabry de l'Institut d'Optique, CNRS, Université Paris-Sud, Palaiseau Cedex, France. pierre.lecaruyer@institutoptique.fr
authors.forename: P
authors.initials: P
authors.lastname: Lecaruyer
authors.forename: M
authors.initials: M
authors.lastname: Canva
authors.forename: J
authors.initials: J
authors.lastname: Rolland
mesh_terms: D000465:Algorithms; D015374:Biosensing Techniques / Q000295:instrumentation* / Q000379:methods; D017076:Computer-Aided Design; D004867:Equipment Design; D019544:Equipment Failure Analysis; D008567:Membranes, Artificial; D008670:Metals / Q000737:chemistry* / Q000528:radiation effects*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D020349:Surface Plasmon Resonance / Q000295:instrumentation* / Q000379:methods
chemical_list: D008567:Membranes, Artificial; D008670:Metals