Secondary glioblastoma multiforme after treatment for primary choroid plexus carcinoma in childhood.
A 15-year-old boy was diagnosed with choroid plexus carcinoma (CPC) of the right lateral ventricle. His metastatic work-up was negative. After complete macroscopic resection of the tumor, the patient was treated with chemotherapy consisting of vincristine, cisplatin, etoposide, and carboplatin, followed by radiotherapy for a total dose of 34.2 Gy on the whole craniospinal axis plus a boost of 19.8 Gy at the tumor region. The patient remained in complete clinical and radiologic remission over the next 5 years when a secondary malignant tumor, glioblastoma multiforme, a rare complication of the treatment of CPC, was diagnosed. This case reflects the necessity of thorough follow-up in long-term survivors of CPC.
Postovsky
Sergey
S
Department of Pediatric Hematology-Oncology, Meyer Children's Hospital, Technion-Israel Institute of Technology, Haifa, Israel. s_postovsky@rambam.health.gov.il
Vlodavsky
Eugene
E
Eran
Ayelet
A
Guilburd
Joseph
J
Ben Arush
Myriam Weyl
MW
D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D016190:Carboplatin / Q000008:administration & dosage; D016545:Choroid Plexus Neoplasms / Q000473:pathology* / Q000628:therapy; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D003937:Diagnosis, Differential; D005047:Etoposide / Q000008:administration & dosage; D017809:Fatal Outcome; D005909:Glioblastoma / Q000209:etiology / Q000473:pathology* / Q000628:therapy; D006801:Humans; D008297:Male; D016609:Neoplasms, Second Primary / Q000209:etiology / Q000473:pathology* / Q000628:therapy; D014750:Vincristine / Q000008:administration & dosage
D014750:Vincristine; D005047:Etoposide; D016190:Carboplatin; D002945:Cisplatin