title: Evaluation of N-(phenylmethyl)-4-[5-(phenylmethyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridin-4-yl]benzamide inhibitors of Mycobacterium tuberculosis growth.
abstract: The biological evaluation of imidazopiperidines as FAS II inhibitors of Mycobacterium tuberculosis growth has been carried out with a view to assessment of potential as lead compounds for the development of a new TB drug. A summary of the hit evaluation and current challenges is described herein.
authors.affiliation: GlaxoSmithKline, Medicines Research Centre, Gunnels Wood Road, Stevenage SG1 2NY, UK. michael.d.wall@gsk.com
authors.forename: Michael D
authors.initials: MD
authors.lastname: Wall
authors.forename: Michael
authors.initials: M
authors.lastname: Oshin
authors.forename: Gavin A C
authors.initials: GA
authors.lastname: Chung
authors.forename: Tony
authors.initials: T
authors.lastname: Parkhouse
authors.forename: Andrea
authors.initials: A
authors.lastname: Gore
authors.forename: Esperanza
authors.initials: E
authors.lastname: Herreros
authors.forename: Brian
authors.initials: B
authors.lastname: Cox
authors.forename: Ken
authors.initials: K
authors.lastname: Duncan
authors.forename: Brian
authors.initials: B
authors.lastname: Evans
authors.forename: Martin
authors.initials: M
authors.lastname: Everett
authors.forename: Alfonso
authors.initials: A
authors.lastname: Mendoza
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D001549:Benzamides / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D010880:Piperidines / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D001549:Benzamides; D010880:Piperidines