title: Prevention and treatment of cerebrospinal fluid leak after translabyrinthine acoustic tumor removal.
abstract: OBJECTIVE
  To determine the incidence rate of cerebrospinal fluid (CSF) leak after translabyrinthine acoustic tumor removal using titanium mesh cranioplasty and to compare with previous series and historical controls.
  
  
  METHODS
  Database analysis with historical controls.
  
  
  METHODS
  Tertiary referral neurotologic private practice.
  
  
  METHODS
  The series of 389 patients who underwent titanium mesh cranioplasty after translabyrinthine tumor removal between March 2003 and July 2005. The results were compared with those in a group of 1,195 translabyrinthine tumor removal patients from our previously published series and with those in a group of 324 patients from the immediately preceding two-year period.
  
  
  METHODS
  Cranioplasty using titanium mesh after acoustic tumor removal.
  
  
  METHODS
  Rates of CSF leak for this method and previous methods of closure.
  
  
  RESULTS
  Thirteen patients (3.3%) had CSF leaks when using the new method of titanium mesh closure. This compares with rates of 10.9% and 8.7% in series in which other methods of closure were used (p < 0.001 and 0.003). The rates of CSF leak requiring reoperation were 0.5%, 2.5%, and 1.9% for the new and the two older series, respectively.
  
  
  CONCLUSIONS
  In our hands, titanium mesh cranioplasty seems to reduce the rate of CSF leaks after the translabyrinthine removal of acoustic tumors.
authors.affiliation: House Clinic and House Ear Institute, Los Angeles, California 90057, USA. jfayad@hei.org
authors.forename: Jose N
authors.initials: JN
authors.lastname: Fayad
authors.forename: Marc S
authors.initials: MS
authors.lastname: Schwartz
authors.forename: William H
authors.initials: WH
authors.lastname: Slattery
authors.forename: Derald E
authors.initials: DE
authors.lastname: Brackmann
mesh_terms: D000328:Adult; D000368:Aged; D001672:Biocompatible Materials; D002558:Cerebrospinal Fluid Otorrhea / Q000209:etiology* / Q000517:prevention & control* / Q000601:surgery; D003056:Cochlear Nerve / Q000473:pathology* / Q000601:surgery*; D003390:Cranial Nerve Neoplasms / Q000473:pathology* / Q000601:surgery*; D007758:Ear, Inner / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013506:Otologic Surgical Procedures / Q000379:methods*; D011183:Postoperative Complications / Q000517:prevention & control*; D013526:Surgical Mesh; D014025:Titanium / Q000627:therapeutic use
chemical_list: D001672:Biocompatible Materials; D014025:Titanium