Normalization of dye bias in microarray data using the mixture of splines model.
This paper discusses characteristics of dye biases in microarray data that the conventional normalization methods do not handle, and proposes a new normalization method involving a mixture of splines model. We also develop a test for between-group comparisons of each gene that is designed to be used with our proposed method.
Joo
Yongsung
Y
University of Florida, USA. yjoo@phhp.ufl.edu
Casella
George
G
Booth
James
J
Lee
Keunbaik
K
Enkemann
Steven
S
D018076:DNA, Complementary; D005456:Fluorescent Dyes; D008962:Models, Theoretical; D020411:Oligonucleotide Array Sequence Analysis; D020133:Reverse Transcriptase Polymerase Chain Reaction
D018076:DNA, Complementary; D005456:Fluorescent Dyes