title: Complete response of deep neutrophilic dermatosis associated with myelodysplastic syndrome to 5-azacytidine.
abstract: Cutaneous manifestations of myelodysplastic syndromes (MDS) may predict disease progression and a poorer prognosis. We describe a patient in whom a deep neutrophilic dermatosis preceded evolution of disease from refractory anaemia to RAEB (refractory anaemia with excess blasts) and resolved completely on treating the disease with 5-azacytidine. The dermatological response was accompanied by complete bone marrow remission and trilineage haematological improvement. We suggest that 5-azacytidine should be considered in the treatment of immune mediated cutaneous manifestations of MDS.
authors.affiliation: Department of Haematological Medicine, King's College London and King's College Hospital, Denmark Hill, London, UK.
authors.forename: K
authors.initials: K
authors.lastname: Raj
authors.forename: A
authors.initials: A
authors.lastname: Ho
authors.forename: J D
authors.initials: JD
authors.lastname: Creamer
authors.forename: A W P
authors.initials: AW
authors.lastname: du Vivier
authors.forename: J R
authors.initials: JR
authors.lastname: Salisbury
authors.forename: G J
authors.initials: GJ
authors.lastname: Mufti
mesh_terms: D000368:Aged; D000754:Anemia, Refractory, with Excess of Blasts / Q000150:complications; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use*; D001374:Azacitidine / Q000627:therapeutic use*; D006257:Head; D006801:Humans; D008297:Male; D009333:Neck; D012074:Remission Induction; D012782:Shoulder; D012871:Skin Diseases / Q000188:drug therapy* / Q000209:etiology
chemical_list: D000964:Antimetabolites, Antineoplastic; D001374:Azacitidine