title: Polyspecificity of T cell and B cell receptor recognition.
abstract: A recent workshop discussed the recognition of multiple distinct ligands by individual T cell and B cell receptors and the implications of this discovery for lymphocyte biology. The workshop recommends general use of the term polyspecificity because it emphasizes two fundamental aspects, the inherent specificity of receptor recognition and the ability to recognize multiple ligands. Many different examples of polyspecificity and the structural mechanisms were discussed, and the group concluded that polyspecificity is a general, inherent feature of TCR and antibody recognition. This review summarizes the relevance of polyspecificity for lymphocyte development, activation and disease processes.
authors.affiliation: Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA. kai_wucherpfennig@dfci.harvard.edu
authors.forename: Kai W
authors.initials: KW
authors.lastname: Wucherpfennig
authors.forename: Paul M
authors.initials: PM
authors.lastname: Allen
authors.forename: Franco
authors.initials: F
authors.lastname: Celada
authors.forename: Irun R
authors.initials: IR
authors.lastname: Cohen
authors.forename: Rob
authors.initials: R
authors.lastname: De Boer
authors.forename: K Christopher
authors.initials: KC
authors.lastname: Garcia
authors.forename: Byron
authors.initials: B
authors.lastname: Goldstein
authors.forename: Ralph
authors.initials: R
authors.lastname: Greenspan
authors.forename: David
authors.initials: D
authors.lastname: Hafler
authors.forename: Philip
authors.initials: P
authors.lastname: Hodgkin
authors.forename: Erik S
authors.initials: ES
authors.lastname: Huseby
authors.forename: David C
authors.initials: DC
authors.lastname: Krakauer
authors.forename: David
authors.initials: D
authors.lastname: Nemazee
authors.forename: Alan S
authors.initials: AS
authors.lastname: Perelson
authors.forename: Clemencia
authors.initials: C
authors.lastname: Pinilla
authors.forename: Roland K
authors.initials: RK
authors.lastname: Strong
authors.forename: Eli E
authors.initials: EE
authors.lastname: Sercarz
mesh_terms: D000818:Animals; D017951:Antigen Presentation / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D006801:Humans; D008024:Ligands; D008213:Lymphocyte Activation / Q000276:immunology*; D051379:Mice; D010455:Peptides / Q000276:immunology; D011948:Receptors, Antigen, T-Cell / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D008024:Ligands; D010455:Peptides; D011948:Receptors, Antigen, T-Cell