title: Autoimmune pancreatitis with extreme elevation of DUPAN-2.
abstract: An 80-year-old woman was admitted to our hospital with complaints of jaundice and liver dysfunction. She was found to have a high titer of serum IgG4, positive rheumatoid factor and marked elevation of DUPAN-2 (11,148 U/ml). Computed tomography showed swelling of the pancreas, and endoscopic retrograde cholangiopancreatography revealed diffuse irregular narrowing of the main pancreatic duct, which are typical findings of autoimmune pancreatitis. There was no evidence of malignancy. Administration of 30 mg/day of prednisolone was started. Computed tomography showed significant regression in the size of the pancreas, and the stenosis of the main pancreatic duct was improved on ERCP. The serum level of DUPAN-2 was also markedly decreased after the treatment.
authors.affiliation: Department of Internal Medicine, Nagasaki Municipal Hospital, Nagasaki, Japan.
authors.forename: Shiho
authors.initials: S
authors.lastname: Mishima
authors.forename: Yohei
authors.initials: Y
authors.lastname: Mizuta
authors.forename: Takuji
authors.initials: T
authors.lastname: Yamao
authors.forename: Masaki
authors.initials: M
authors.lastname: Yamakawa
authors.forename: Yuko
authors.initials: Y
authors.lastname: Akazawa
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Mishima
authors.forename: Kazuo
authors.initials: K
authors.lastname: Ohba
authors.forename: Jun-ich
authors.initials: JI
authors.lastname: Masuda
authors.forename: Ken
authors.initials: K
authors.lastname: Ohnita
authors.forename: Hajime
authors.initials: H
authors.lastname: Isomoto
authors.forename: Saburo
authors.initials: S
authors.lastname: Shikuwa
authors.forename: Katsuhisa
authors.initials: K
authors.lastname: Omagari
authors.forename: Shigeru
authors.initials: S
authors.lastname: Kohno
mesh_terms: D000208:Acute Disease; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000369:Aged, 80 and over; D000951:Antigens, Neoplasm / Q000097:blood*; D001327:Autoimmune Diseases / Q000097:blood* / Q000175:diagnosis* / Q000188:drug therapy; D015415:Biomarkers / Q000097:blood; D002760:Cholangiopancreatography, Endoscopic Retrograde / Q000379:methods; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D010186:Pancreatic Function Tests; D010190:Pancreatic Neoplasms / Q000175:diagnosis; D010195:Pancreatitis / Q000097:blood* / Q000175:diagnosis* / Q000188:drug therapy; D018570:Risk Assessment; D012720:Severity of Illness Index; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones; D000951:Antigens, Neoplasm; D015415:Biomarkers; C042317:DU-PAN-2 antigen, human