title: [Assessment of preclinical cognition impairment in hypertension patients with functional magnetic resonance imaging].
abstract: OBJECTIVE
  To explore whether the hypertension patients with no clinical cognitive impairment manifestations have certain brain dysfunctions.
  
  
  METHODS
  Twenty-five moderately to severely hypertensive patients, males and females, aged 63.0 +/- 1.6 (60 approximately 65), with a disease history if 5 to 10 years, and 25 sex, age, and educational level-matched healthy persons underwent tests by mini-mental status examination (MMSE) scales, state anxiety inventory (STAI-S) and trait anxiety inventory (STAI-T), and then underwent two functional magnetic resonance imaging (fMRI) studies. In Experiment 1, the subjects were demanded to listen actively to the meaningless words (pseudowords) and in Experiment 2 the subjects listened actively to real words and make the valence (abstract or concrete) of the words in silence. The subjects were told to listen passively the noise from the MR scanners during the resting period, which was used as the control task. The fMRI data were analyzed with statistical parametric mapping (SPM99) software.
  
  
  RESULTS
  The MMSE score of the patient group was 29.3 +/- 1.1, not significantly different from that of the control group (29.6 +/- 0.5, P > 0.05). The STAI-S score of the patient group was 47 +/- 5.3748, significantly higher than that of the control group (41.6 +/- 4.9777, P < 0.05). The STAI-S score of the patient group was 45 +/- 3, not significantly different from that of the control group (43 +/- 4, t = 1.0619, P = 0.3032). In Experiment 1, the activated patterns and deactivated patterns were nearly similar for the patient and control groups. The activated regions included the bilateral superior temporal lobe, bilateral inferior frontal cortex and supplementary motor areas. In Experiment 2, the activated patterns were also nearly similar for these 2 groups. The regions included the bilateral superior temporal lobe, bilateral inferior frontal cortex, left angular gyrus, bilateral superior frontal cortex, bilateral cerebellum, premotor areas, and supplementary motor areas. The deactivation patterns were similar for the patients and controls both in Experiment 1 and Experiment 2. These regions were medial prefrontal cortex, posterior cingulate and bilateral inferior parietal cortex, which nearly overlapping with the default model network proposed by Raichle et al. However, the activation and deactivation magnitude and extent of the brain were significantly greater for the patients than for the controls both in Experiment 1 and Experiment 2.
  
  
  CONCLUSIONS
  Some brain dysfunction may have already existed in patients with moderately to severely hypertension disorders, though their behavior performance scores are within the normal range of ages. The fMRI technique can be a useful tool to detect the preclinical brain abnormalities.
authors.affiliation: Radiology Department of Tongji Hospital of Tongji University, Shanghai 200065, China.
authors.forename: Xiao-hu
authors.initials: XH
authors.lastname: Zhao
authors.forename: Pei-jun
authors.initials: PJ
authors.lastname: Wang
authors.forename: Bing
authors.initials: B
authors.lastname: Jie
authors.forename: Qian
authors.initials: Q
authors.lastname: Xi
authors.forename: Lu
authors.initials: L
authors.lastname: Gan
authors.forename: Tao
authors.initials: T
authors.lastname: Lei
mesh_terms: D000368:Aged; D003072:Cognition Disorders / Q000175:diagnosis* / Q000209:etiology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000523:psychology; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity