title: [A case report of a recurrence of Mooren's ulcer after cataract surgery].
abstract: We report the case of Mooren's ulcer recurrence after uncomplicated cataract surgery in a 61-year-old woman. This cataract developed because of repetitive inflammation of the anterior chamber and corticotherapy. Local and general corticotherapy with cyclosporin 2% drops was started in association with an anterior lamellar graft and a conjunctival recession due to a preperforation condition. Secondarily cyclophosphamide was necessary to control recurrence with a good anatomic result and an increase in visual acuity. The case updates physiopathologic and diagnostic data on this rare limbic autoimmune ulcerative disease. The diagnosis was made by histology and the dosage of specific autoantibodies against cornea. The prevention of recurrence after surgery requires a long clinical quiescent period, minimally invasive surgery long after inflammation has subsided, and a gradual tapering of corticotherapy over several weeks.
authors.affiliation: Service d'ophtalmologie, Hôpital Pellegrin, CHU, Bordeaux.
authors.forename: C
authors.initials: C
authors.lastname: Schweitzer
authors.forename: D
authors.initials: D
authors.lastname: Touboul
authors.forename: C
authors.initials: C
authors.lastname: Ghiringhelli
authors.forename: J
authors.initials: J
authors.lastname: Colin
mesh_terms: D001324:Autoantigens / Q000276:immunology; D001327:Autoimmune Diseases / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology / Q000601:surgery; D003131:Combined Modality Therapy; D003228:Conjunctiva / Q000601:surgery; D003231:Conjunctivitis / Q000209:etiology; D003315:Cornea / Q000276:immunology; D016039:Corneal Transplantation; D003320:Corneal Ulcer / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology / Q000601:surgery; D016572:Cyclosporine / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008875:Middle Aged; D018716:Molecular Mimicry; D009504:Neutrophils / Q000276:immunology; D018918:Phacoemulsification; D011183:Postoperative Complications / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology / Q000601:surgery; D012008:Recurrence; D009418:S100 Proteins / Q000276:immunology; D000067616:S100A12 Protein; D014792:Visual Acuity
chemical_list: D001324:Autoantigens; D007166:Immunosuppressive Agents; D009418:S100 Proteins; D000067616:S100A12 Protein; C090441:S100A12 protein, human; D016572:Cyclosporine