title: Impact of gemcitabine on the survival of patients with stage IV pancreatic cancer.
abstract: OBJECTIVE
  The prognosis of patients with advanced pancreatic cancer remains very poor. This study was designed to elucidate the prognostic factors of patients with pancreatic cancer to evaluate appropriate treatment with gemcitabine.
  
  
  METHODS
  Ninety-nine consecutive patients with stage IV pancreatic cancer were treated in the gemcitabine era at the Kobe University Hospital. Prognostic variables for survival were analyzed (sex, age, performance status, main site of the tumor, tumor size, major vessel invasion, distal metastasis, resection, gemcitabine, radiation, and pathological factors). The Cox proportional hazards model was used to determine the factors influencing the survival of patients with stage IV pancreatic cancer.
  
  
  RESULTS
  Multivariate analysis revealed that pancreatic resection, gemcitabine, and distant metastasis significantly influenced the survival of all patients with stage IV pancreatic cancer. Pancreatic resection and gemcitabine were significant factors influencing the survival of patients with stage IVa pancreatic cancer, whereas gemcitabine was the strongest factor influencing stage IVb pancreatic cancer.
  
  
  CONCLUSIONS
  Gemcitabine has a possible role for stage IV pancreatic cancer.
authors.affiliation: Department of Gastroenterological Surgery, Kobe University Graduate School of Medicine, Kobe, Japan. yasu120@med.kobe-u.ac.jp
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Fujino
authors.forename: Takashi
authors.initials: T
authors.lastname: Ueda
authors.forename: Takashi
authors.initials: T
authors.lastname: Kamigaki
authors.forename: Shiro
authors.initials: S
authors.lastname: Takase
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Ajiki
authors.forename: Yasuhisa
authors.initials: Y
authors.lastname: Kamoda
authors.forename: Ippei
authors.initials: I
authors.lastname: Matsumoto
authors.forename: Takeo
authors.initials: T
authors.lastname: Yasuda
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Kuroda
mesh_terms: D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use*; D003841:Deoxycytidine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D010190:Pancreatic Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology / Q000601:surgery; D011379:Prognosis; D012189:Retrospective Studies; D016019:Survival Analysis; D000093542:Gemcitabine
chemical_list: D000964:Antimetabolites, Antineoplastic; D003841:Deoxycytidine; D000093542:Gemcitabine