NADPH diaphorase reactive neurons in temporal lobe cortex of patients with intractable epilepsy and hippocampal sclerosis.
Several studies have demonstrated a controversial involvement of NO in epileptogenesis. The aim of this study is to compare the NADPH diaphorase (NADPH-d) reactivity in the temporal cortex between surgical specimens of patients with intractable epilepsy and hippocampal sclerosis and autopsy controls. Brain samples of patients and postmortem controls were stained with the NADPH-d technique. Sprouting and larger areas of NADPH-d reactive neurons were found in the temporal cortex of epileptic patients.
D'Alessio
Luciana
L
Buenos Aires University, Institute of Molecular Biology, E de Robertis, Ramos Mejia Hospital, Epilepsy Center, Urquiza 609, Capital Federal, Buenos Aires 1201, Argentina. ldalessio@intramed.net.ar <ldalessio@intramed.net.ar>
López-Costa
Juan José
JJ
Konopka
Héctor
H
Consalvo
Damián
D
Seoane
Eduardo
E
López
María Esther
ME
Guelman
María Laura
ML
Kochen
Silvia
S
Zieher
Luis María
LM
D000368:Aged; D004351:Drug Resistance; D004569:Electroencephalography; D004827:Epilepsy / Q000188:drug therapy / Q000201:enzymology* / Q000473:pathology; D005260:Female; D006624:Hippocampus / Q000201:enzymology* / Q000473:pathology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D009252:NADPH Dehydrogenase / Q000378:metabolism*; D009474:Neurons / Q000201:enzymology* / Q000473:pathology; D009569:Nitric Oxide / Q000378:metabolism; D012598:Sclerosis; D013702:Temporal Lobe / Q000201:enzymology* / Q000473:pathology; D016610:Tissue Embedding
D009569:Nitric Oxide; D009252:NADPH Dehydrogenase