Natural products with calmodulin inhibitor properties.
This review summarizes properties of various naturally occurring compounds with reported calmodulin (CaM)-inhibitory properties which include about 159 natural products belonging to different structural classes. Most inhibitors are alkaloid and peptide type of compounds and have been isolated from a wide variety of natural sources, including many plant species. Among the most potent natural anti-CaM substances, however, are several animal venoms and the antibiotic polymixin. The largest number of compounds described were discovered by means of enzymatic functional assays.
Martínez-Luis
Sergio
S
Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, DF 04510, Mexico.
Pérez-Vásquez
Araceli
A
Mata
Rachel
R
D000818:Animals; D001688:Biological Products / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology*; D002147:Calmodulin / Q000037:antagonists & inhibitors* / Q000378:metabolism; D006801:Humans; D013329:Structure-Activity Relationship
D001688:Biological Products; D002147:Calmodulin