[Kidney protein complexes that inhibit gene expression in the nuclei of homotypic cells].
The comparative study of protein complexes (PCs) isolated by alcohol extraction from white rat and human nephrocytes (post-operational material) have been performed. It has been shown that PCs of white rat cells inhibit RNA synthesis in the nuclei of intact as well as nephrectomized (unilateral nephrectomy) animals. The same effect has been shown while studying the PCs of patients with hydronephrotic kidneys. At the same time the inhibition of transcription has not been detected in case of RCC kidney cancer cell PCs. The chromatography studies revealed that the active component of PCs (12 kDa protein factor) which had been detected earlier has not been shown up in cancer cells of human kidney.
Dzidziguri
D V
DV
Chigogidze
T G
TG
Managadze
L G
LG
Aslamazishvili
T T
TT
Kerkendzhiia
S M
SM
D000818:Animals; D002467:Cell Nucleus / Q000473:pathology; D015870:Gene Expression / Q000502:physiology*; D006801:Humans; D006869:Hydronephrosis / Q000235:genetics / Q000473:pathology*; D007680:Kidney Neoplasms / Q000378:metabolism* / Q000473:pathology*; D046912:Multiprotein Complexes / Q000502:physiology*; D051381:Rats; D014157:Transcription Factors / Q000235:genetics*; D015291:Transforming Growth Factors / Q000378:metabolism*
D046912:Multiprotein Complexes; D014157:Transcription Factors; D015291:Transforming Growth Factors