title: Inhibition of melanogenesis by selina-4(14),7(11)-dien-8-one isolated from Atractylodis Rhizoma Alba.
abstract: To develop effective skin-lightening agents, we tested medicinal herbal extracts for their melanogenic-inhibitory activities. We isolated a sesquiterpenoid compound from the extract of Atractylodis Rhizoma Alba using the bioactivity-guided fractionation and identified it as selina-4(14),7(11)-dien-8-one (compound 1) with spectroscopic methods. Compound 1 dramatically reduced melanin synthesis of melan-a cells without any apparent cytotoxicity. Compound 1 did not inhibit cell-free tyrosinase activity but decreased tyrosinase activity in melanocytes. These effects were attributed to reduced expression of melanogenic enzymes such as tyrosinase, tyrosinase-related protein 1 (TRP-1), and tyrosinase-related protein 2 (TRP-2). These results suggest that compound 1 may be an effective skin-lightening agent that regulates expression of melanogenic enzymes.
authors.affiliation: Personal Care Research Center, LG Household & Healthcare Ltd, Korea.
authors.forename: Yun-Hee
authors.initials: YH
authors.lastname: Chang
authors.forename: CheongTaek
authors.initials: C
authors.lastname: Kim
authors.forename: Minhwan
authors.initials: M
authors.lastname: Jung
authors.forename: Young-Hee
authors.initials: YH
authors.lastname: Lim
authors.forename: Sanghwa
authors.initials: S
authors.lastname: Lee
authors.forename: Sangjin
authors.initials: S
authors.lastname: Kang
mesh_terms: D000818:Animals; D031174:Atractylodes / Q000737:chemistry*; D002478:Cells, Cultured; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D008543:Melanins / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D008544:Melanocytes / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D008546:Melanoma, Experimental / Q000201:enzymology / Q000378:metabolism / Q000473:pathology*; D051379:Mice; D014442:Monophenol Monooxygenase / Q000378:metabolism; D010858:Pigmentation / Q000187:drug effects*; D010936:Plant Extracts / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D027343:Rhizome / Q000737:chemistry; D012717:Sesquiterpenes / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D008543:Melanins; D010936:Plant Extracts; D012717:Sesquiterpenes; D014442:Monophenol Monooxygenase