Effect of interesterification of palmitic acid-rich triacylglycerol on postprandial lipid and factor VII response.
The process of interesterification results in changes in triacylglycerol (TAG) structure and is used to increase the melting point of dietary fats. The acute health effects of this process on palmitic acid-rich fats are uncertain with regard to postprandial lipemia, insulin and factor VII activated (FVIIa) concentrations. Two randomized crossover trials in healthy male subjects compared the effects of meals containing 50 g fat [interesterified palm oil (IPO) versus native palm oil (NPO); n=20, and IPO versus high-oleic sunflower oil (HOS); n=18], on postprandial changes in lipids, glucose, insulin, chylomicron composition and FVIIa. Compared with NPO, IPO decreased postprandial TAG and insulin concentrations. Both NPO and IPO increased FVIIa concentrations postprandially; mean increases at 6 h were 21 and 19%, respectively. Compared with HOS, IPO decreased postprandial TAG (47% lower incremental area under the curve) and reduced the postprandial increase in FVIIa concentration by 64% at 6 h; no significant differences in hepatic and total lipase activities or insulin concentrations were noted. All three test meals increased postprandial leukocyte counts (average 26% at 6 h). The fatty acid composition of the chylomicron TAG was similar to the test fats following all test meals. It is concluded that interesterification of palm oil does not result in adverse changes in postprandial lipids, insulin or FVIIa compared to high oleate and native palm oils.
Berry
Sarah E E
SE
Department of Nutrition and Dietetics, Nutritional Sciences Research Division, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London, SE1 9NH, UK. sarah.e.berry@kcl.ac.uk
Woodward
Rebecca
R
Yeoh
Christabelle
C
Miller
George J
GJ
Sanders
Thomas A B
TA
D000293:Adolescent; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D002914:Chylomicrons / Q000378:metabolism; D018592:Cross-Over Studies; D004041:Dietary Fats / Q000008:administration & dosage / Q000494:pharmacology; D004952:Esters; D005167:Factor VII / Q000378:metabolism*; D006801:Humans; D007328:Insulin / Q000097:blood / Q000378:metabolism; D007962:Leukocytes / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D050356:Lipid Metabolism / Q000187:drug effects; D008055:Lipids / Q000737:chemistry*; D008297:Male; D008875:Middle Aged; D000073878:Palm Oil; D019308:Palmitic Acid / Q000737:chemistry*; D010938:Plant Oils / Q000008:administration & dosage / Q000494:pharmacology; D019518:Postprandial Period; D000074242:Sunflower Oil; D014280:Triglycerides / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*
D001786:Blood Glucose; D002914:Chylomicrons; D004041:Dietary Fats; D004952:Esters; D007328:Insulin; D008055:Lipids; D010938:Plant Oils; D000074242:Sunflower Oil; D014280:Triglycerides; D019308:Palmitic Acid; D000073878:Palm Oil; D005167:Factor VII