title: Sequence and recombination analyses of the geminivirus replication initiator protein.
abstract: The sequence motifs present in the replication initiator protein (Rep) of geminiviruses have been compared with those present in all known rolling circle replication initiators. The predicted secondary structures of Rep representing each group of organisms have been compared and found to be conserved. Regions of recombination in the Rep gene and the adjoining 5' intergenic region (IR)of representative species of Geminiviridae have been identified using Recombination Detection Programs. The possible implications of such recombinations on the increasing host range of geminivirus infections are discussed.
authors.affiliation: Center for Excellence in Bioinformatics, School of Biotechnology, Madurai Kamaraj University, Madurai 625 21, India.
authors.forename: T
authors.initials: T
authors.lastname: Vadivukarasi
authors.forename: K R
authors.initials: KR
authors.lastname: Girish
authors.forename: R
authors.initials: R
authors.lastname: Usha
mesh_terms: D000595:Amino Acid Sequence; D004265:DNA Helicases / Q000737:chemistry* / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000737:chemistry* / Q000235:genetics*; D017791:Geminiviridae / Q000737:chemistry* / Q000145:classification / Q000235:genetics; D008969:Molecular Sequence Data; D010802:Phylogeny; D017433:Protein Structure, Secondary; D011995:Recombination, Genetic; D016415:Sequence Alignment; D015534:Trans-Activators / Q000737:chemistry* / Q000235:genetics*; D014764:Viral Proteins / Q000737:chemistry* / Q000235:genetics*; D014779:Virus Replication
chemical_list: D004268:DNA-Binding Proteins; D015534:Trans-Activators; D014764:Viral Proteins; C045264:replication initiator protein; D004265:DNA Helicases