title: Trauma and aggressive homeostasis management.
abstract: Three important issues concerning homeostasis in the acute care of trauma patients that are related directly to the stress response are hyperglycemia, lactic acidosis, and hypothermia. Recently, there has been a resurgence of interest in investigating the effects of aggressive thermal and glucose concentration and volume resuscitation on outcomes in critically ill and trauma patients. Significant reason exists to question the "conventional wisdom" relating to current approaches to restoring homeostasis in this patient population.
authors.affiliation: Department of Anesthesiology and Critical Care, Hospital of University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA. baranovd@uphs.upenn.edu
authors.forename: Dimitry
authors.initials: D
authors.lastname: Baranov
authors.forename: Patrick
authors.initials: P
authors.lastname: Neligan
mesh_terms: D000138:Acidosis / Q000097:blood / Q000628:therapy; D000818:Animals; D001930:Brain Injuries / Q000628:therapy; D006706:Homeostasis; D006801:Humans; D006943:Hyperglycemia / Q000209:etiology / Q000628:therapy; D007035:Hypothermia / Q000209:etiology / Q000628:therapy; D019344:Lactic Acid / Q000097:blood; D012771:Shock, Hemorrhagic / Q000209:etiology / Q000628:therapy; D014947:Wounds and Injuries / Q000628:therapy*
chemical_list: D019344:Lactic Acid