Mutation analysis of NANOS3 in 80 Chinese and 88 Caucasian women with premature ovarian failure.
NANOS3 encodes an RNA-binding protein and has a conserved function in germ cell development. Our objective was to investigate whether mutations in NANOS3 were present in Chinese and Caucasian women with premature ovarian failure. A known synonymous single-nucleotide polymorphism (rs 2016163) in exon 1 was identified through sequencing 80 Chinese and 88 Caucasian women with premature ovarian failure. No additional single-nucleotide polymorphisms or mutations were found in exons encoding for NANOS3. Our findings suggest that mutations in NANOS3 exons are rare in both Chinese and Caucasian women with premature ovarian failure.
Qin
Yingying
Y
Center for Reproductive Medicine, Shandong Provincial Hospital, Shandong University, Jinan, China.
Zhao
Han
H
Kovanci
Ertug
E
Simpson
Joe Leigh
JL
Chen
Zi-Jiang
ZJ
Rajkovic
Aleksandar
A
D000293:Adolescent; D000328:Adult; D044466:Asian People / Q000235:genetics*; D004252:DNA Mutational Analysis / Q000379:methods; D005260:Female; D006801:Humans; D009154:Mutation; D020641:Polymorphism, Single Nucleotide; D016649:Primary Ovarian Insufficiency / Q000235:genetics*; D016601:RNA-Binding Proteins / Q000235:genetics*; D044465:White People / Q000235:genetics*
C524848:NANOS3 protein, human; D016601:RNA-Binding Proteins