title: A possible role for TSLP in inflammatory arthritis.
abstract: Thymic stromal lymphopoietin (TSLP) is an IL-7-like cytokine that triggers dendritic cell-mediated Th2-type inflammatory responses and is considered as a master switch for allergic inflammation. In this study, we found increased levels of TSLP and, also TNF-alpha as previously reported, in synovial fluid specimens derived from patients with rheumatoid arthritis (RA) when compared with those from patients with osteoarthritis (OA). In addition, TNF-alpha up-regulated TSLP expression in RA- and OA-derived synovial fibroblasts, which was inhibited by IFN-gamma. Furthermore, anti-TSLP neutralizing antibody ameliorated a TNF-alpha-dependent experimental arthritis induced by anti-type II collagen antibody in mice. Collectively, these results suggest that TSLP, as a downstream molecule of TNF-alpha, may be involved in the pathophysiology of inflammatory arthritis. TSLP might thus play a role not only in allergic diseases but also in inflammatory arthritis such as RA.
authors.affiliation: Department of Immunology, Faculty of Medicine, University of Yamanashi, Chuo, Yamanashi 409-3898, Japan.
authors.forename: Kensuke
authors.initials: K
authors.lastname: Koyama
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Ozawa
authors.forename: Kyosuke
authors.initials: K
authors.lastname: Hatsushika
authors.forename: Takashi
authors.initials: T
authors.lastname: Ando
authors.forename: Shinichi
authors.initials: S
authors.lastname: Takano
authors.forename: Masanori
authors.initials: M
authors.lastname: Wako
authors.forename: Fumiko
authors.initials: F
authors.lastname: Suenaga
authors.forename: Yuko
authors.initials: Y
authors.lastname: Ohnuma
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Ohba
authors.forename: Ryohei
authors.initials: R
authors.lastname: Katoh
authors.forename: Hajime
authors.initials: H
authors.lastname: Sugiyama
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Hamada
authors.forename: Hideoki
authors.initials: H
authors.lastname: Ogawa
authors.forename: Ko
authors.initials: K
authors.lastname: Okumura
authors.forename: Atsuhito
authors.initials: A
authors.lastname: Nakao
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001172:Arthritis, Rheumatoid / Q000276:immunology*; D002478:Cells, Cultured; D016207:Cytokines / Q000276:immunology*; D005260:Female; D005347:Fibroblasts / Q000187:drug effects / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000276:immunology*; D013582:Synovial Fluid / Q000187:drug effects / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000008:administration & dosage* / Q000276:immunology*; D000094632:Thymic Stromal Lymphopoietin
chemical_list: D016207:Cytokines; D014409:Tumor Necrosis Factor-alpha; D000094632:Thymic Stromal Lymphopoietin