Inhibition of cytochrome P-450 with 2-diethylamino-ethyl-2,2-diphenylpropylacetate (SKF-525A) reduces immunotoxicity of chlorinated carbohydrates.
Experiments on outbred albino rats showed that single intraperitoneal injection of cytochrome P-450 inhibitor 2-diethylaminoethyl-2,2-diphenylpropylacetate (SKF-525A) in a dose of 50 mg/kg before acute poisoning with 1,2-dichloroethane and trichloroethane in a dose of 1.0 LD(50), metabolized in the body to compounds with higher toxicity (the phenomenon of "lethal synthesis") reduced their immunotoxicity by decreasing the formation of their biotransformation products.
Zabrodskii
P F
PF
Saratov Military Institute of Radiation, Chemical, and Biological Protection. pz@renet.com.ru
Mandych
V G
VG
Germanchuk
V G
VG
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D001402:B-Lymphocytes / Q000276:immunology; D065607:Cytochrome P-450 Enzyme Inhibitors; D003601:Cytotoxicity Tests, Immunologic; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D005025:Ethylene Dichlorides / Q000493:pharmacokinetics* / Q000633:toxicity; D005260:Female; D007075:Immunoglobulin M / Q000096:biosynthesis; D008297:Male; D011335:Proadifen / Q000494:pharmacology*; D051381:Rats; D013053:Spectrophotometry; D013154:Spleen / Q000276:immunology; D018417:Th1 Cells / Q000276:immunology; D014241:Trichloroethylene / Q000493:pharmacokinetics* / Q000633:toxicity
D065607:Cytochrome P-450 Enzyme Inhibitors; D004791:Enzyme Inhibitors; D005025:Ethylene Dichlorides; D007075:Immunoglobulin M; D014241:Trichloroethylene; C024565:ethylene dichloride; D011335:Proadifen