Specific activities of poetam preparation (superlow-doses of antibodies to erythropoietin) and recombinant erythropoietin.
We compared the capacity of superlow-dose of antibodies to erythropoietin (Poetam) and recombinant erythropoietin (Recormon) to stimulate the recovery of adriamycin-suppressed erythropoiesis in mice. Both preparations exhibited high erythron activation capacity and considerably increased the content of erythrocytes and reticulocytes in the peripheral blood and content of erythrokaryocytes and erythroid precursors in the hemopoietic tissue of experimental animals. The effect of Recormon manifested immediately after injection, while the effect of Poetam was somewhat delayed, but more lasting (due to activation of host erythropoietin system).
Dygai
A M
AM
Institute of Pharmacology, Tomsk Research Center, Siberian Division of Russian Academy of Medical Sciences.
Zhdanov
V V
VV
Udut
E V
EV
Simanina
E V
EV
Gur'yantseva
L A
LA
Khrichkova
T Yu
TY
Epshtein
O I
OI
Sergeeva
S A
SA
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology; D000906:Antibodies / Q000494:pharmacology*; D004317:Doxorubicin / Q000494:pharmacology; D004797:Enzyme-Linked Immunosorbent Assay; D004906:Erythrocyte Count; D004909:Erythrocyte Indices / Q000187:drug effects; D004912:Erythrocytes / Q000187:drug effects*; D004920:Erythropoiesis / Q000187:drug effects*; D004921:Erythropoietin / Q000494:pharmacology*; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D011994:Recombinant Proteins
D000903:Antibiotics, Antineoplastic; D000906:Antibodies; D006454:Hemoglobins; D011994:Recombinant Proteins; D004921:Erythropoietin; D004317:Doxorubicin