Live birth after the transfer of human embryos developed from cryopreserved oocytes harvested before cancer treatment.
OBJECTIVE
To document the first successful fertility preservation with freezing mature oocytes for a cancer patient.


METHODS
Case report.


METHODS
Private IVF center.


METHODS
A woman with Hodgkin's disease and her gestational carrier.


METHODS
Metaphase II oocytes cryopreserved before cancer treatments were thawed and fertilized for transfer to a gestational carrier.


METHODS
Post-thaw survival and pregnancy.


RESULTS
Ten of the 12 metaphase II oocytes survived the thawing process. Nine oocytes were fertilized after microinjection with her husband's sperm. All fertilized oocytes developed into good quality embryos and were transferred to a gestational carrier in three cycles. A biochemical pregnancy was achieved after the second transfer. A singleton pregnancy was achieved after the last transfer of three embryos, resulting in the birth of a healthy male.


CONCLUSIONS
Our findings suggest that oocyte cryopreservation should be considered as a preferred strategy for the cancer patient who has time to cryopreserve oocytes before cancer treatment.
Yang
Dunsong
D
Florida Institute for Reproductive Medicine, Jacksonville, Florida 32207, USA. firmdsyang@aol.com
Brown
Samuel E
SE
Nguyen
Kevin
K
Reddy
Vijay
V
Brubaker
Cindy
C
Winslow
Kevin L
KL
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000008:administration & dosage; D005260:Female; D005307:Fertilization in Vitro; D006689:Hodgkin Disease / Q000188:drug therapy* / Q000532:radiotherapy*; D006801:Humans; D007231:Infant, Newborn; D050498:Live Birth; D009865:Oocytes / Q000502:physiology*; D010062:Ovulation Induction / Q000379:methods; D011241:Prednisone / Q000008:administration & dosage; D011247:Pregnancy; D011344:Procarbazine / Q000008:administration & dosage; D011878:Radiotherapy / Q000009:adverse effects; D014021:Tissue Preservation / Q000379:methods*; D020858:Tissue and Organ Harvesting / Q000379:methods; D014750:Vincristine / Q000008:administration & dosage
D011344:Procarbazine; D014750:Vincristine; D003520:Cyclophosphamide; D011241:Prednisone