Effect of mexidol and nitroglycerine on iron-sulfur centers, cytochrome P-450, and nitric oxide formation in liver tissue of experimental animals.
In experiments on mice we studied the effect of individual or combined treatment with mexidol and nitroglycerine on iron-sulfur centers of the mitochondrial respiratory chain, cytochrome P-450 of the endoplasmic reticulum, and nitric oxide formation in the liver tissue. Mexidol had a potent effect on these parameters and protected iron-sulfur centers from oxidation, including that induced by nitroglycerine.
Belaya
O L
OL
Institute of Biochemical Physics, Russian Academy of Sciences, Moscow. olgabelaya@km.ru
Baider
L M
LM
Kuropteva
Z V
ZV
D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000187:drug effects / Q000378:metabolism*; D004578:Electron Spin Resonance Spectroscopy; D007506:Iron-Sulfur Proteins / Q000187:drug effects / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D051379:Mice; D009569:Nitric Oxide / Q000096:biosynthesis*; D005996:Nitroglycerin / Q000494:pharmacology*; D010847:Picolines / Q000494:pharmacology*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D051381:Rats; D011918:Rats, Inbred SHR; D014665:Vasodilator Agents / Q000494:pharmacology
D007506:Iron-Sulfur Proteins; D010847:Picolines; D010975:Platelet Aggregation Inhibitors; D014665:Vasodilator Agents; C070020:emoxypine succinate; D009569:Nitric Oxide; D003577:Cytochrome P-450 Enzyme System; D005996:Nitroglycerin