title: Symptom control trials: a 20-year experience.
abstract: Symptoms related to cancer and/or cancer therapy are a prominent consideration in cancer patients; multiple options have been proposed to alleviate these problems. The US National Cancer Institute (NCI) Community Clinical Oncology Program (CCOP) has mandated that CCOP participant institutions be involved with cancer control trials in addition to cancer treatment trials. Through such efforts, scientifically sound symptom control clinical trials are being conducted to determine the effectiveness of promising agents. In this article, the authors provide an update of clinical trial outcomes regarding 13 symptom and symptom complexes related to cancer and/or cancer therapy, emphasizing that publication of both positive and negative study results is important to separate what works from what does not.
authors.affiliation: Division of Medical Oncology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA. cloprinzi@mayo.edu
authors.forename: Charles L
authors.initials: CL
authors.lastname: Loprinzi
authors.forename: Debra L
authors.initials: DL
authors.lastname: Barton
authors.forename: Aminah
authors.initials: A
authors.lastname: Jatoi
authors.forename: Jeff
authors.initials: J
authors.lastname: Sloan
authors.forename: Jim
authors.initials: J
authors.lastname: Martenson
authors.forename: David
authors.initials: D
authors.lastname: Steensma
authors.forename: Ravi
authors.initials: R
authors.lastname: Rao
authors.forename: Paul
authors.initials: P
authors.lastname: Novotny
authors.forename: Amit
authors.initials: A
authors.lastname: Sood
authors.forename: Axel
authors.initials: A
authors.lastname: Grothey
authors.forename: Lori
authors.initials: L
authors.lastname: Minasian
authors.forename: Harold
authors.initials: H
authors.lastname: Windschitl
mesh_terms: D000740:Anemia / Q000209:etiology / Q000517:prevention & control; D000855:Anorexia / Q000209:etiology / Q000517:prevention & control; D000970:Antineoplastic Agents / Q000009:adverse effects; D002100:Cachexia / Q000209:etiology / Q000517:prevention & control; D002986:Clinical Trials as Topic; D005221:Fatigue / Q000209:etiology / Q000517:prevention & control; D019584:Hot Flashes / Q000209:etiology / Q000517:prevention & control; D006801:Humans; D008209:Lymphedema / Q000209:etiology / Q000517:prevention & control; D052016:Mucositis / Q000209:etiology / Q000517:prevention & control; D009369:Neoplasms / Q000150:complications / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D009422:Nervous System Diseases / Q000209:etiology / Q000517:prevention & control; D010024:Osteoporosis / Q000209:etiology / Q000517:prevention & control; D010146:Pain / Q000209:etiology / Q000517:prevention & control; D011878:Radiotherapy / Q000009:adverse effects; D012871:Skin Diseases / Q000209:etiology / Q000517:prevention & control; D007319:Sleep Initiation and Maintenance Disorders / Q000209:etiology / Q000517:prevention & control
chemical_list: D000970:Antineoplastic Agents