Model of immunogenic uveitis in rabbits.
Six models of experimental immunogenic uveitis induced by injection of normal horse serum were tried in rabbits. A convenient working variant of the model was developed characterized by high activity and long duration of the inflammatory process in the eye. Creation of this model requires pre-sensitization (subcutaneous injection of 5 ml normal horse serum) followed by intravitreal injection of the resolving dose of horse serum on day 9. An adapted improved model of experimental immunogenic uveitis in rabbits is proposed.
Neroev
V V
VV
Helmholtz Institute of Ocular Diseases, Russian Ministry of Health, Moscow.
Davydova
G A
GA
Perova
T S
TS
D000818:Animals; D004195:Disease Models, Animal; D006736:Horses / Q000097:blood; D011817:Rabbits; D014605:Uveitis / Q000209:etiology / Q000276:immunology*