title: Total synthesis of gymnorrhizol, an unprecedented 15-membered macrocyclic polydisulfide from the Chinese mangrove Bruguiera gymnorrhiza.
abstract: [reaction: see text] The total synthesis of gymnorrhizol, a naturally occurring macrocyclic polydisulfide with a new skeleton and a potent proteintyrosinephosphatase 1B inhibitor, was prepared in three steps, starting from (R)-1-bromo-3-chloroisopropanol and 1,3-dichloropropan-2-ol.
authors.affiliation: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, People's Republic of China.
authors.forename: Jing-Xu
authors.initials: JX
authors.lastname: Gong
authors.forename: Xu
authors.initials: X
authors.lastname: Shen
authors.forename: Li-Gong
authors.initials: LG
authors.lastname: Yao
authors.forename: Hualiang
authors.initials: H
authors.lastname: Jiang
authors.forename: Karsten
authors.initials: K
authors.lastname: Krohn
authors.forename: Yue-Wei
authors.initials: YW
authors.lastname: Guo
mesh_terms: D004220:Disulfides / Q000138:chemical synthesis / Q000737:chemistry*; D047028:Macrocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D043982:Rhizophoraceae / Q000737:chemistry*
chemical_list: D004220:Disulfides; D047028:Macrocyclic Compounds; C520145:gymnorrhizol