Measurements of cerebrospinal fluid concentrations of S100beta protein during and after thoracic endovascular stent grafting.
OBJECTIVE
Thoracic endovascular aortic repair is associated with postoperative spinal cord ischemia in approximately 1 to 12.5% of all cases. S100beta is a protein that is released during acute damage of the central nervous system. This study was performed to determine the concentration of S100beta in cerebrospinal fluid during and after stenting of the thoracic aorta in patients at high risk for spinal cord ischemia.


METHODS
Prospective clinical study.


METHODS
Eight patients who underwent elective thoracic aortic stent grafting underwent lumbar spinal fluid drainage. These patients were at high risk to develop spinal cord ischemia.


METHODS
CSF samples for analysis of S100beta protein were drawn after induction of anesthesia, during stenting, once every hour the following six hours and 20 hours after repair.


RESULTS
No significant increase in S100beta protein could be detected in CSF and no neurological deficits were detected postoperatively.


CONCLUSIONS
The results of this study show us that there is no significant release of S100beta protein in CSF during stenting of the thoracic aorta in this subgroup of patients at high risk for spinal cord ischemia, consistent with clinical exam that there was no significant damage to the central nervous system.
Brunnekreef
G B
GB
Department of Anesthesiology and Intensive Care, St. Antonius Hospital, The Netherlands. brunnekreef@hotmail.com
Heijmen
R H
RH
Gerritsen
W B
WB
Schepens
M A
MA
ter Beek
H T
HT
van Dongen
E P
EP
D000368:Aged; D017545:Aortic Aneurysm, Thoracic / Q000134:cerebrospinal fluid / Q000601:surgery*; D015415:Biomarkers / Q000134:cerebrospinal fluid; D019917:Blood Vessel Prosthesis Implantation / Q000009:adverse effects* / Q000295:instrumentation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009414:Nerve Growth Factors / Q000134:cerebrospinal fluid*; D011446:Prospective Studies; D018570:Risk Assessment; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000134:cerebrospinal fluid*; D020760:Spinal Cord Ischemia / Q000134:cerebrospinal fluid / Q000209:etiology*; D015607:Stents; D016896:Treatment Outcome
D015415:Biomarkers; D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins