Telomeres and telomerase: Biological and clinical importance in dogs.
In recent years in human oncology the enzyme telomerase has emerged as an ideal target for cancer therapy. This has led to the assessment of telomerase in cancers in companion animals, mainly dogs and these studies confirm that in dogs, like humans, telomere maintenance by telomerase is the primary mechanism by which cancer cells overcome their mortality and extend their lifespan. This review aims to provide an introduction to the biology of telomeres and telomerase and to discuss some of the telomere/telomerase directed therapeutic methodologies currently under development which may be of benefit to the canine cancer patient.
Nasir
Lubna
L
Institute of Comparative Medicine, University of Glasgow, Faculty of Veterinary Medicine, Bearsden Road, Glasgow G61 1QH, UK. l.nasir@vet.gla.ac.uk
D000818:Animals; D002455:Cell Division / Q000502:physiology; D004283:Dog Diseases / Q000201:enzymology*; D004285:Dogs; D009369:Neoplasms / Q000188:drug therapy / Q000201:enzymology / Q000662:veterinary*; D019098:Telomerase / Q000037:antagonists & inhibitors / Q000378:metabolism*; D016615:Telomere / Q000378:metabolism*
D019098:Telomerase