Da-Cheng-Qi-Tang promotes the recovery of gastrointestinal motility after abdominal surgery in humans.
In order to examine the effects of Da-Cheng-Qi-Tang (DCQT) on gastrointestinal motility functions after abdominal surgery in humans, 33 patients with abdominal surgeries and 36 patients with cholecystectomies were divided into the DCQT and the control groups at random. Electrogastrography (EGG) and gastroduodenojejunal manometry was performed and the levels of plasma motilin were measured by radioimmunoassay. The results were as follows: (1) on the day of surgery, the ratio of EGG normal frequency in the DCQT group was higher than in the control group (P=0.0016); (2) the power of EGG in the DCQT group was higher than in the control group on the second and third days after surgeries (P=0.0011 and P=0.0215, respectively); (3) the percentage of normal bowel peristalsis was significantly higher in the DCQT group than in the control group (P<0.01); and (4) in the DCQT group, the plasma motilin level reached its peak earlier than in the control group. Our results suggest that DCQT can increase plasma motilin, enhance gastrointestinal motility, improve gastric dysrythmia, and reduce gastroparesis after abdominal surgery.
Qi
Qing Hui
QH
Department of General Surgery, The First Affiliated Hospital, Dalian Medical School, Dalian, Liaoning Province, China. qiqh@medmail.com.cn
Wang
Jian
J
Liang
Guo Gang
GG
Wu
Xian Zhong
XZ
D000328:Adult; D000368:Aged; D013505:Digestive System Surgical Procedures / Q000009:adverse effects*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use*; D004576:Electromyography; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects*; D006801:Humans; D007418:Intestinal Pseudo-Obstruction / Q000188:drug therapy / Q000209:etiology / Q000517:prevention & control*; D008297:Male; D008365:Manometry; D008875:Middle Aged; D009037:Motilin / Q000097:blood; D010936:Plant Extracts; D011863:Radioimmunoassay
D004365:Drugs, Chinese Herbal; D010936:Plant Extracts; C477169:dachengqi decoction; D009037:Motilin