Evaluation of urine N1,N12-Diacetylspermine as potential tumor marker for urinary bladder cancer.
BACKGROUND
N1,N12-diacetylspermine, a diacetylpolyamine which was recently identified in urine, appeared to be a useful tumor marker for a number of cancers. No valid data on urine diacetylspermine concentration in patients with urinary bladder cancer exist.


OBJECTIVE
Evaluation of urine N1,N12-diacetylspermine concentrations in individuals with urinary bladder cancer.


METHODS
Urine samples were used from 36 patients with urothelial tumors of the urinary bladder and from 30 patients with benign urological diseases. Urine was collected before cystoscopy. Enzyme-linked immunoabsorbent assays (ELISA) were performed for diacetylspermine from urine.


RESULTS
Urine diacetylspermine did not differentiate in individuals with urinary bladder cancer from controls (medians 171.5 vs 143.8, p = 0.64). Its efficacy for urinary bladder cancer detection was not shown.


CONCLUSIONS
Urine N1,N12-diacetylspermine is probably not a useful marker for urinary bladder cancer.
Stejskal
David
D
Department of Laboratory Medicine, Sternberk Hospital, Czech Republic. stejskal@nemstbk.cz
Humenanska
Viera
V
Hanulova
Zuzana
Z
Fiala
Richard
R
Vrtal
Radovan
R
Solichova
Pavlina
P
Karpisek
Michal
M
D014408:Biomarkers, Tumor / Q000652:urine*; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D008875:Middle Aged; D013096:Spermine / Q000031:analogs & derivatives* / Q000652:urine; D001749:Urinary Bladder Neoplasms / Q000175:diagnosis*
D014408:Biomarkers, Tumor; D013096:Spermine; C029453:N',N''-diacetylspermine