title: Fronto-striatal overactivation in euthymic bipolar patients during an emotional go/nogo task.
abstract: OBJECTIVE
  Although euthymic bipolar patients show minimal manic and depressive symptoms, they continue to show impaired emotional regulation and cognitive functioning. Few studies have directly examined the interference of emotional information with cognitive processes and its underlying cerebral mechanisms in euthymic bipolar patients. The authors examined the emotional modulation of cognitive processes and its underlying neural mechanisms in euthymic bipolar patients.
  
  
  METHODS
  Seventeen euthymic bipolar patients and 17 healthy comparison subjects underwent functional magnetic resonance imaging (MRI) while performing an emotional and nonemotional go/nogo task. Neural responses associated with the overall task performance, as well as with the impact of emotional information on the task performance, were assessed.
  
  
  RESULTS
  Bipolar disorder patients exhibited increased activity in the temporal cortex, specifically to emotional go/nogo conditions, as well as in the orbitofrontal cortex, the insula, the caudate nuclei, and the dorsal anterior and posterior cingulate cortices when inhibiting emotional stimuli compared with neutral stimuli. Conversely, no global attentional deficits were observed on either a behavioral or neural response level, indicated by similar task performances for all task conditions and similar brain activation patterns when comparing all the go/nogo conditions with the resting state.
  
  
  CONCLUSIONS
  The present study provides evidence of an altered emotional modulation of cognitive processing in euthymic bipolar patients, indicated by an overactivation in ventral-limbic, temporal, and dorsal brain structures during emotional go/nogo conditions in patients relative to comparison subjects.
authors.affiliation: Inserm U797, CEA-INSERM Research Unit Neuroimaging and Psychiatry, IFR49, University Paris-Sud 11 and University Paris 5, Hospital Department Frédéric Joliot, 91401 Orsay, France. michele.wessa@zi-mannheim.de
authors.forename: Michèle
authors.initials: M
authors.lastname: Wessa
authors.forename: Josselin
authors.initials: J
authors.lastname: Houenou
authors.forename: Marie-Laure
authors.initials: ML
authors.lastname: Paillère-Martinot
authors.forename: Sylvie
authors.initials: S
authors.lastname: Berthoz
authors.forename: Eric
authors.initials: E
authors.lastname: Artiges
authors.forename: Marion
authors.initials: M
authors.lastname: Leboyer
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Martinot
mesh_terms: D000328:Adult; D001479:Basal Ganglia / Q000502:physiology*; D001714:Bipolar Disorder / Q000175:diagnosis*; D001931:Brain Mapping; D003071:Cognition / Q000502:physiology*; D004644:Emotions / Q000502:physiology*; D005149:Facial Expression; D005260:Female; D005625:Frontal Lobe / Q000502:physiology*; D006801:Humans; D008032:Limbic System / Q000502:physiology; D008279:Magnetic Resonance Imaging / Q000706:statistics & numerical data*; D008297:Male; D011597:Psychomotor Performance / Q000502:physiology*; D011930:Reaction Time / Q000502:physiology; D013647:Task Performance and Analysis