Current role of glucosamine in the treatment of osteoarthritis.
OBJECTIVE
To evaluate the interest of using the various preparations of glucosamine for symptomatic and structural management of osteoarthritis (OA).


METHODS
A critical analysis of the literature based on an exhaustive search (Medline, PubMed and manual search within the bibliography of retrieved manuscripts) from 1980 to 2005.


RESULTS
Despite multiple controlled clinical trials of the use of glucosamine in OA (mainly of the knee), controversy on efficacy related to symptomatic improvement continues. Differences in results originate from the differences in products, study design and study populations. Symptomatic efficacy described in multiple studies performed with glucosamine sulphate (GS) support continued consideration in the OA therapeutic armamentarium. The most compelling evidence of a potential for inhibiting the progression of OA is also obtain with GS.


CONCLUSIONS
GS has shown positive effects on symptomatic and structural outcomes of knee OA. These results should not be extrapolated to other glucosamine salts [hydrochloride or preparations (over-the-counter or food supplements)] in which no warranty exists about content, pharmacokinetics and pharmacodynamics of the tablets.
Reginster
J-Y
JY
WHO Collaborating Center, Department of Public Health, Epidemiology and Health Economics, University of Liège, Liège, Belgium. jyreginster@ulg.ac.be
Bruyere
O
O
Neuprez
A
A
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D019587:Dietary Supplements; D005944:Glucosamine / Q000627:therapeutic use*; D006801:Humans; D010003:Osteoarthritis / Q000188:drug therapy*; D020370:Osteoarthritis, Knee / Q000188:drug therapy; D016032:Randomized Controlled Trials as Topic; D016896:Treatment Outcome
D000894:Anti-Inflammatory Agents, Non-Steroidal; D005944:Glucosamine