Phosphine containing oligonucleotides for the development of metallodeoxyribozymes.
Novel transition metal catalysts based on oligonucleotides can be easily obtained by functionalization of 5-iodouridine with phosphine ligands, resulting in good asymmetric induction in palladium catalyzed allylic nucleophilic substitution.
Ropartz
Loïc
L
School of Chemistry, University of St. Andrews, St. Andrews, Fife, UK. pcjk@st-andrews.ac.uk
Meeuwenoord
Nico J
NJ
van der Marel
Gijsbert A
GA
van Leeuwen
Piet W N M
PW
Slawin
Alexandra M Z
AM
Kamer
Paul C J
PC
D002384:Catalysis; D003461:Crystallography; D021881:DNA, Catalytic / Q000138:chemical synthesis* / Q000737:chemistry; D007065:Idoxuridine / Q000031:analogs & derivatives* / Q000737:chemistry; D008024:Ligands; D009841:Oligonucleotides / Q000138:chemical synthesis* / Q000737:chemistry; D010165:Palladium / Q000737:chemistry*; D010720:Phosphines / Q000032:analysis*; D028561:Transition Elements / Q000737:chemistry
D021881:DNA, Catalytic; D008024:Ligands; D009841:Oligonucleotides; D010720:Phosphines; D028561:Transition Elements; C035991:5-iodouridine; D010165:Palladium; C044646:phosphine; D007065:Idoxuridine