Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1.
A series of 4-hydroxy-4-phenylpiperidines have been synthesized and bind to the nociceptin receptor with high affinity. The synthesis and structure-activity relationships at the N-1 and C-4 are described.
Ho
Ginny D
GD
Department of Chemical Research-CV & CNS, Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA. ginny.ho@spcorp.com
Bercovici
Ana
A
Tulshian
Deen
D
Greenlee
William J
WJ
Fawzi
Ahmad
A
Smith Torhan
April
A
Zhang
Hongtao
H
D000818:Animals; D016466:CHO Cells; D006224:Cricetinae; D003412:Cricetulus; D006801:Humans; D008024:Ligands; D015394:Molecular Structure; D010880:Piperidines / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism*; D011957:Receptors, Opioid / Q000378:metabolism*; D013329:Structure-Activity Relationship; D000094942:Nociceptin Receptor
D008024:Ligands; D010880:Piperidines; D011957:Receptors, Opioid; D000094942:Nociceptin Receptor