Brugada syndrome masquerading as febrile seizures.
Fever can precipitate ventricular tachycardia in adults with Brugada syndrome, but such a link has not been reported in children. A 21-month-old white girl presented repeatedly with decreased conscious level and seizures during fever. During a typical episode, rapid ventricular tachycardia was documented. The resting 12-lead electrocardiogram revealed a Brugada electrocardiogram signature. Resting electrocardiograms of the asymptomatic brother and mother were normal, but fever in the mother and pharmacologic stress with ajmaline in the brother revealed Brugada electrocardiogram features. Genetic testing revealed an SCN5A mutation in the affected family members.
Skinner
Jonathan Robert
JR
Greenlane Paediatric and Congenital Cardiac Services, Starship Children's Hospital, Grafton, Auckland, New Zealand. jskinner@adhb.govt.nz
Chung
Seo-Kyung
SK
Nel
Carey-Anne
CA
Shelling
Andrew Neil
AN
Crawford
Jackie Robyn
JR
McKenzie
Neil
N
Pinnock
Ralph
R
French
John Kerswell
JK
Rees
Mark Ian
MI
D053840:Brugada Syndrome / Q000175:diagnosis* / Q000235:genetics / Q000503:physiopathology; D003937:Diagnosis, Differential; D004562:Electrocardiography; D005260:Female; D006801:Humans; D007223:Infant; D009124:Muscle Proteins / Q000235:genetics; D009154:Mutation; D062554:NAV1.5 Voltage-Gated Sodium Channel; D003294:Seizures, Febrile / Q000175:diagnosis* / Q000235:genetics / Q000503:physiopathology; D015222:Sodium Channels / Q000235:genetics
D009124:Muscle Proteins; D062554:NAV1.5 Voltage-Gated Sodium Channel; C568320:SCN5A protein, human; D015222:Sodium Channels