title: Multiple osseous metastases of a carotid body tumor in a dog.
abstract: Metastasis of malignant carotid body tumor to multiple bones was detected in a 13-year-old female Siberian husky dog. Radiographs exhibited an abnormal mass in the retropharyngeal site and osteolytic lesions in the vertebral bodies, spinous process, tibia, and ribs. At necropsy, multiple masses were observed in the bones as well as at the dorsal area of the retropharynx. Histologically, the tumor cells, arranged in sheets and clusters, had eosinophilic finely granular cytoplasm. Immunohistochemistry showed the tumor cells were positive for neuron-specific enolase and synaptophysin. Electron microscopy demonstrated a number of dense membrane-bound granules in the cytoplasm of the tumor cells. Based on these findings, this case was diagnosed as multiple bone metastases of a malignant carotid body tumor. Spinal cord damage induced by the tumor mass was the cause of the hind limb paralysis of the present dog.
authors.affiliation: Department of Veterinary Pathology, Tottori University, Japan.
authors.forename: Mina
authors.initials: M
authors.lastname: Okajima
authors.forename: Akinori
authors.initials: A
authors.lastname: Shimada
authors.forename: Takehito
authors.initials: T
authors.lastname: Morita
authors.forename: Masako
authors.initials: M
authors.lastname: Yoshikawa
authors.forename: Koji
authors.initials: K
authors.lastname: Nishida
mesh_terms: D000818:Animals; D001859:Bone Neoplasms / Q000378:metabolism* / Q000662:veterinary*; D002345:Carotid Body Tumor / Q000000981:diagnostic imaging / Q000662:veterinary*; D004283:Dog Diseases / Q000000981:diagnostic imaging*; D004285:Dogs; D017809:Fatal Outcome; D005260:Female; D007150:Immunohistochemistry / Q000662:veterinary; D008854:Microscopy, Electron / Q000662:veterinary; D011859:Radiography