title: Noninferiority of antibody response to human papillomavirus type 16 in subjects vaccinated with monovalent and quadrivalent L1 virus-like particle vaccines.
abstract: The incorporation of multiple antigens into a single human papillomavirus (HPV) vaccine may induce immune interference. To evaluate whether interference occurs when HPV type 16 (HPV16) virus-like particles are combined in a multivalent vaccine, we conducted a study to evaluate anti-HPV16 responses among subjects receiving three-dose regimens of either a monovalent HPV16 vaccine or a quadrivalent HPV (types 6, 11, 16, and 18) vaccine.
authors.affiliation: Microbiology and Infectious Diseases Department, Royal Women's Hospital, Carlton, University of Melbourne, Melbourne, Victoria, Australia.
authors.forename: Suzanne M
authors.initials: SM
authors.lastname: Garland
authors.forename: Marc
authors.initials: M
authors.lastname: Steben
authors.forename: Mauricio
authors.initials: M
authors.lastname: Hernandez-Avila
authors.forename: Laura A
authors.initials: LA
authors.lastname: Koutsky
authors.forename: Cosette M
authors.initials: CM
authors.lastname: Wheeler
authors.forename: Gonzalo
authors.initials: G
authors.lastname: Perez
authors.forename: Diane M
authors.initials: DM
authors.lastname: Harper
authors.forename: Sepp
authors.initials: S
authors.lastname: Leodolter
authors.forename: Grace W K
authors.initials: GW
authors.lastname: Tang
authors.forename: Daron G
authors.initials: DG
authors.lastname: Ferris
authors.forename: Mark T
authors.initials: MT
authors.lastname: Esser
authors.forename: Scott C
authors.initials: SC
authors.lastname: Vuocolo
authors.forename: Micki
authors.initials: M
authors.lastname: Nelson
authors.forename: Radha
authors.initials: R
authors.lastname: Railkar
authors.forename: Carlos
authors.initials: C
authors.lastname: Sattler
authors.forename: Eliav
authors.initials: E
authors.lastname: Barr
mesh_terms: D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000096:biosynthesis; D000917:Antibody Formation / Q000276:immunology*; D004311:Double-Blind Method; D005260:Female; D052162:Human papillomavirus 16 / Q000276:immunology*; D006801:Humans; D030361:Papillomavirus Infections / Q000517:prevention & control*; D053918:Papillomavirus Vaccines / Q000008:administration & dosage / Q000145:classification* / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D053918:Papillomavirus Vaccines