Histologic eosinophilia as an aid to diagnose acute cellular rejection after living donor liver transplantation.
The significance of histologic eosinophilia in the diagnosis of acute cellular rejection (ACR) after living donor liver transplantation was evaluated. A retrospective analysis was performed on 185 liver biopsy specimens to determine the presence of eosinophil infiltration around the portal tracts. Data were collected and analyzed to determine whether there was a correlation between ACR and the maximum eosinophil counts per portal triad (Em) and the rate of portal triads that included at least one eosinophil (Er). A receiver operating characteristic curve revealed the best cut-off value of Em and Er as 2% and 8% respectively. The sensitivity and specificity of an Em of two to predict ACR were 54% and 84% respectively. The sensitivity and specificity of Er were 72% and 65% respectively. One-way analysis of variance revealed that both Em and Er correlated with ACR severity. Histologic eosinophilia can be a useful parameter for confirming the occurrence of ACR and for evaluating ACR severity.
Kishi
Yoji
Y
Artificial Organ and Transplantation Division, Department of Surgery, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
Sugawara
Yasuhiko
Y
Tamura
Sumihito
S
Kaneko
Junichi
J
Matsui
Yuichi
Y
Makuuchi
Masatoshi
M
D004802:Eosinophilia / Q000209:etiology*; D006084:Graft Rejection / Q000175:diagnosis*; D006801:Humans; D008103:Liver Cirrhosis / Q000601:surgery; D016031:Liver Transplantation / Q000276:immunology; D019520:Living Donors; D012372:ROC Curve; D012189:Retrospective Studies; D012680:Sensitivity and Specificity