Prognostic value of serum free light chain ratio at diagnosis in multiple myeloma.
The prognostic value of baseline serum free light chain ratio (sFLCR) was investigated in 94 multiple myeloma (MM) patients. sFLCR was calculated as kappa/lambda or lambda/kappa, depending on the patients' dominating monoclonal light chain. Median baseline sFLCR was 3.57 in kappa-MM patients, 45.09 in lambda-MM. 'High' sFLCR (> or = the observed median value for kappa- and lambda-MM respectively) correlated with elevated serum creatinine and lactate dehydrogenase, extensive marrow infiltration and light chain type MM. The 5-year disease-specific survival was 82% and 30% in patients with sFLCR lower than and equal or greater than the median, respectively (P = 0.0001). sFLCR was an independent prognostic factor.
Kyrtsonis
Marie-Christine
MC
Department of Haematology, National and Kapodistrian University of Athens, Laikon General Hospital, Athens, Greece.
Vassilakopoulos
Theodoros P
TP
Kafasi
Nicoletta
N
Sachanas
Sotirios
S
Tzenou
Tatiana
T
Papadogiannis
Argiroula
A
Galanis
Zacharoula
Z
Kalpadakis
Christina
C
Dimou
Maria
M
Kyriakou
Elias
E
Angelopoulou
Maria K
MK
Dimopoulou
Maria N
MN
Siakantaris
Marina P
MP
Dimitriadou
Evangelia M
EM
Kokoris
Styliani I
SI
Panayiotidis
Panayiotis
P
Pangalis
Gerassimos A
GA
D000368:Aged; D015415:Biomarkers / Q000097:blood; D001853:Bone Marrow / Q000473:pathology; D003404:Creatinine / Q000097:blood; D005260:Female; D006801:Humans; D007147:Immunoglobulin Light Chains / Q000097:blood*; D007145:Immunoglobulin kappa-Chains / Q000097:blood; D007146:Immunoglobulin lambda-Chains / Q000097:blood; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000097:blood / Q000175:diagnosis* / Q000401:mortality; D011379:Prognosis; D016019:Survival Analysis
D015415:Biomarkers; D007147:Immunoglobulin Light Chains; D007145:Immunoglobulin kappa-Chains; D007146:Immunoglobulin lambda-Chains; D003404:Creatinine; D007770:L-Lactate Dehydrogenase