title: [Clinical features and prognosis of IgA nephropathy with glomerular crescents].
abstract: OBJECTIVE
  To understand the clinical features and prognosis of IgA nephropathy (IgAN) patients with glomerular crescents.
  
  
  METHODS
  The clinical data collected at the time of renal biopsy and the follow-up data of 89 IgAN patients with glomerular crescents were analyzed with 412 IgAN patients without crescents serving as the control group. Follow-up study was conducted in 78 patients with crescents and 198 without it, and the renal survival rate was estimated using Kaplan-Meier survival analysis.
  
  
  RESULTS
  The incidence of glomerular crescents was 17.8% in IgAN patients. Clinically, 39 patients with crescents experienced rapidly progressive glomerulonephritis, resulting in a significantly higher rate of this manifestation than that in patients without crescent. Patients with crescents also had more grave pathological changes in the glomerulus and renal tubule interstitium than the control patients. Patients were followed up for an average of 40.3-/+29.6 months in crescent group and 45.1-/+26.9 months in the control group, and the 1-, 3-, 5-year renal survival rate was 95.24%, 80.95%, 61.9% in the former and 100%, 91.67%, 79.17% in the latter, respectively.
  
  
  CONCLUSIONS
  IgAN patients with crescents have severer clinical and pathological manifestations and poorer prognosis than those without crescents.
authors.affiliation: Department of Nephrology, Second Affiliated Hospital of Sun Yat-sen University, Guangzhou 510120, China.
authors.forename: Xia
authors.initials: X
authors.lastname: Wan
authors.forename: Jing-gao
authors.initials: JG
authors.lastname: Li
authors.forename: Jie
authors.initials: J
authors.lastname: Bai
authors.forename: Hu-hui
authors.initials: HH
authors.lastname: Huang
authors.forename: Xiao-yan
authors.initials: XY
authors.lastname: Su
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002681:China / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D005922:Glomerulonephritis, IGA / Q000401:mortality / Q000473:pathology*; D006801:Humans; D053208:Kaplan-Meier Estimate; D007678:Kidney Glomerulus / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D015996:Survival Rate