title: Hydroperoxysterols from the tunicate Eudistoma sp.
abstract: Two 27C hydroperoxysterols, 7beta-hydroperoxycholesterol (1) and its stereoisomer 7alpha-hydroperoxycholesterol (2), were isolated from the lipophilic extracts of a Formosan tunicate belonging to the genus Eudistoma. The structures of sterols 1 and 2 were elucidated on the basis of extensive spectral data analyses. Cytotoxicity of sterols 1 and 2 against a limited panel of cancer cell lines is also described. Sterol 1 show weak inhibitory effects on human neutrophil elastase release.
authors.affiliation: National Museum of Marine Biology and Aquarium, Pingtung, Taiwan, R.O.C. pjsung@nmmba.gov.tw
authors.forename: Ping-Jyun
authors.initials: PJ
authors.lastname: Sung
authors.forename: Mei-Ru
authors.initials: MR
authors.lastname: Lin
authors.forename: Jih-Jung
authors.initials: JJ
authors.lastname: Chen
authors.forename: Shen-Fan
authors.initials: SF
authors.lastname: Lin
authors.forename: Yang-Chang
authors.initials: YC
authors.lastname: Wu
authors.forename: Tsong-Long
authors.initials: TL
authors.lastname: Hwang
authors.forename: Lee-Shing
authors.initials: LS
authors.lastname: Fang
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D002851:Chromatography, High Pressure Liquid; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013261:Sterols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014561:Urochordata / Q000737:chemistry*
chemical_list: D013261:Sterols