title: An 18-norspirostanol saponin with inhibitory action against COX-2 production from the underground part of Trillium tschonoskii.
abstract: A novel 18-norspirostanol saponin (1), along with Trillenoside A (2), was obtained from the underground parts of Trillium tschonoskii MAXIM., collected in Shennongjia Forest District, China. Based on the chemical and spectroscopic evidences, their structures were determined as shown in Fig. 1. 1 and 2 displayed marked inhibitory action towards COX-2 production in macrophagocytes of the mouse abdominal cavity stimulated by LPS at 10 microg/ml.
authors.affiliation: Hubei Key Laboratory of Natural Products Research and Development, College of Chemistry and Life Science, China Three Gorges University, Yichang, P.R. China.
authors.forename: Junzhi
authors.initials: J
authors.lastname: Wang
authors.forename: Kun
authors.initials: K
authors.lastname: Zou
authors.forename: Yanming
authors.initials: Y
authors.lastname: Zhang
authors.forename: Chuang
authors.initials: C
authors.lastname: Liu
authors.forename: Jun
authors.initials: J
authors.lastname: Wu
authors.forename: Yuan
authors.initials: Y
authors.lastname: Zhou
authors.forename: Feijun
authors.initials: F
authors.lastname: Dan
authors.forename: Yaxiong
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000818:Animals; D051546:Cyclooxygenase 2 / Q000096:biosynthesis*; D016861:Cyclooxygenase Inhibitors / Q000302:isolation & purification / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008810:Mice, Inbred C57BL; D018517:Plant Roots / Q000737:chemistry*; D012503:Saponins / Q000302:isolation & purification / Q000494:pharmacology*; D031446:Trillium / Q000737:chemistry*
chemical_list: D016861:Cyclooxygenase Inhibitors; D012503:Saponins; D051546:Cyclooxygenase 2