title: A case of exocrine-endocrine neoplasm of the pancreas in a patient with ulcerative colitis with literature review.
abstract: Until now only Japanese authors have reported 4 cases of pancreatic neoplasm associated with ulcerative colitis (UC). We report on a case of a 44-year-old woman who was operated on for complicated UC and an exocrine-endocrine neoplasm of the pancreas, where the endocrine component was presented by pancreatic polypeptide (PP)-producing cells. By means of molecular genetics methods we found microsatellite instability (MSI) in the markers D18S35, FGA and p53 in the colonic lining, and loss of heterozygosity (LOH) in the p53 marker in the pancreatic tumor. A literature review concerning the coexistence of these two conditions showed that PP is involved in the pathogenesis of the UC and that UC increases the risk of development of extracolonic neoplasms.
authors.affiliation: Department of Surgery, University Hospital "Queen Giovanna", Sofia, Bulgaria.
authors.forename: D G
authors.initials: DG
authors.lastname: Nedin
authors.forename: A
authors.initials: A
authors.lastname: Borisova-Alexandrova
authors.forename: A
authors.initials: A
authors.lastname: Todorova-Gegova
authors.forename: E
authors.initials: E
authors.lastname: Petrova-Pophristova
authors.forename: S R
authors.initials: SR
authors.lastname: Donev
authors.forename: T
authors.initials: T
authors.lastname: Kirilova-Kadiyska
authors.forename: V D
authors.initials: VD
authors.lastname: Dimitrov