title: [Study on the vertical transmission of Y chromosome microdeletions from father to son].
abstract: OBJECTIVE
  To analyze the Y chromosome microdeletions in the family of the infertile male and to study on the vertical transmission of Y chromosome microdeletions from father to son.
  
  
  METHODS
  The peripheral blood of infertile patients' family male members was extracted and analyzed with modified multiplex PCR. The infertile family tree was drawn according to the results.
  
  
  RESULTS
  Two cases in twelve investigated families had azoospermia factor (AZFc) microdeletion heredity. The others had no heredity.
  
  
  CONCLUSIONS
  AZFc microdeletion of the Y chromosome can be transmitted to the male offspring naturally,and the same deletion can result in different phenotypes in different individuals.
authors.affiliation: Renji Hospital, Shanghai Jiaotong University, Shanghai, 200001 PR China.
authors.forename: Xiao-bin
authors.initials: XB
authors.lastname: Zhu
authors.forename: Zhen
authors.initials: Z
authors.lastname: Li
authors.forename: An-liang
authors.initials: AL
authors.lastname: Guo
authors.forename: Xiao-rong
authors.initials: XR
authors.lastname: Cao
authors.forename: Yong
authors.initials: Y
authors.lastname: Liu
authors.forename: Dong-ming
authors.initials: DM
authors.lastname: Gong
authors.forename: Yi-xin
authors.initials: YX
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D053713:Azoospermia / Q000235:genetics*; D002872:Chromosome Deletion; D041322:Chromosomes, Human, Y / Q000235:genetics*; D005192:Family Health; D005260:Female; D006801:Humans; D007248:Infertility, Male / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D055815:Young Adult