title: Syndrome of inappropriate antidiuretic hormone secretion and ectopic ACTH production in small cell lung carcinoma.
abstract: BACKGROUND
  Small cell lung carcinoma (SCLC) is frequently associated with a paraneoplastic syndrome.
  
  
  METHODS
  We report on a rare case of SCLC presenting with syndrome of inappropriate antidiuretic hormone (SIADH) secretion and ectopic ACTH production. In accordance with the endocrine evaluation, immunohistochemical staining of the tumour was positive for ADH and ACTH. Chemotherapy with etoposide and carboplatin induced a nearly complete remission.
  
  
  CONCLUSIONS
  Simultaneous secretion of ADH and ACTH is infrequently reported with only five cases described in the literature. SIADH in patients with ectopic ACTH syndrome may be underdiagnosed due to the antagonistic hormone actions of cortisol and ADH on renal sodium excretion.
authors.forename: Karsten
authors.initials: K
authors.lastname: Müssig
authors.forename: Marius
authors.initials: M
authors.lastname: Horger
authors.forename: Hans-Ulrich
authors.initials: HU
authors.lastname: Häring
authors.forename: Manfred
authors.initials: M
authors.lastname: Wehrmann
mesh_terms: D000182:ACTH Syndrome, Ectopic / Q000150:complications* / Q000209:etiology; D000324:Adrenocorticotropic Hormone / Q000096:biosynthesis* / Q000097:blood; D000970:Antineoplastic Agents / Q000008:administration & dosage; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D016190:Carboplatin / Q000008:administration & dosage; D018288:Carcinoma, Small Cell / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000378:metabolism; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007177:Inappropriate ADH Syndrome / Q000150:complications*; D008175:Lung Neoplasms / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000378:metabolism; D008875:Middle Aged; D011859:Radiography; D012074:Remission Induction
chemical_list: D000970:Antineoplastic Agents; D000972:Antineoplastic Agents, Phytogenic; D005047:Etoposide; D000324:Adrenocorticotropic Hormone; D016190:Carboplatin