Plasma NO-binding activity in patients with hematological malignancies: suppressive effect of glucocorticoids.
Plasma NO-binding activity was studied in patients with various forms of hematological malignancies. The method used in the study quantitatively evaluated the plasma capacity to bind NO, which reflects the intensity of NO production and the degree of patient's stress resistance. Plasma NO-binding activity significantly decreases in patients with hematological malignancies. Glucocorticoid treatment promotes the decrease in plasma NO-binding activity, which was dose-dependent.
Petukhov
V I
VI
Riga Stradynia University, Riga.
Kalvinsh
I Ya
IY
Shestakova
I K
IK
Domracheva
I A
IA
Kanepe
I Ya
IY
Stibel
R G
RG
Romanova
M A
MA
Skesters
A P
AP
D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D005938:Glucocorticoids / Q000494:pharmacology* / Q000627:therapeutic use; D019337:Hematologic Neoplasms / Q000097:blood* / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000097:blood*; D011485:Protein Binding
D005938:Glucocorticoids; D009569:Nitric Oxide