Fas antigen and sporadic Alzheimer's disease in Southern Italy: evaluation of two polymorphisms in the TNFRSF6 gene.
Tumor Necrosis Factor Receptor Super Family 6 gene (TNFRSF6), also known as FAS, encodes the Fas antigen, a cell surface receptor mediating cell apoptosis, situated on chromosome 10q located near the region of linkage to sporadic Alzheimer's disease (sAD). FAS levels have been reported elevated in the brain of AD patients. Due to both positional and pathobiological criteria, the association of the FAS antigen with this pathology is of great interest. We have tested two SNPs in the FAS gene in 223 Italian patients with non-familial AD from Southern Italy (Calabria region) and 211 healthy control subjects. No significant differences in allelic and genotypic distributions were found between cases and controls, or late and early-onset AD patients, thus suggesting that these polymorphisms do not represent an AD risk factor in our population.
Andreoli
Virginia
V
Institute of Neurological Sciences, National Research Council, C/da Burga, Pianolago di Mangone, Italy. v.andreoli@isn.cnr.it
Nicoletti
Giuseppe
G
Romeo
Nelide
N
Condino
Francesca
F
La Russa
Antonella
A
Liguori
Maria
M
Manna
Ida
I
Spadafora
Patrizia
P
Quattrone
Aldo
A
Cittadella
Rita
R
D017668:Age of Onset; D000368:Aged; D000544:Alzheimer Disease / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D019014:fas Receptor / Q000032:analysis / Q000235:genetics*
D019014:fas Receptor