Is your metabolism determined by (cell) fate?
The rise in the incidence of metabolic disease to become a major public health problem has been met with a substantial increase in research into both the clinical and basic science of metabolism. This work has revealed that the origins of metabolic diseases of adults can begin early in life. Furthermore, the age of onset of symptoms has been rapidly decreasing. Therefore, pediatricians should be critically involved in both the generation of new therapies as well as the institution of measures of disease prevention. This perspective examines how recent advances have improved our understanding of the development of metabolic diseases. A connection between glucocorticoids and the origins of metabolic disease is one enticing clue because of the clinical similarity between patients with glucocorticoid excess and those with metabolic disease. A unifying link was found by investigating the role of glucocorticoids on cell fate and differentiation of mesenchymal stem cells. We conclude that understanding the mechanisms by which glucocorticoids can modify how cell fate decisions are made holds promise for developing new therapies and preventative measures.
Feldman
Brian J
BJ
Department of Pediatrics, University of California, San Francisco, CA 94143, USA. bfeldman@cmp.ucsf.edu
D050156:Adipogenesis; D000273:Adipose Tissue / Q000378:metabolism*; D000818:Animals; D002648:Child; D003480:Cushing Syndrome / Q000209:etiology* / Q000378:metabolism; D005223:Fats / Q000378:metabolism; D005938:Glucocorticoids / Q000378:metabolism*; D006801:Humans; D008659:Metabolic Diseases / Q000209:etiology* / Q000378:metabolism; D051379:Mice
D005223:Fats; D005938:Glucocorticoids