[Osteoclast differentiation and activation].
In autoimmune arthritis, activation of T cells induces bone destruction through receptor activator of NF-kappaB ligand (RANKL) . Recent study revealed interleukin-17 (IL-17) -producing helper T cell subset (Th17) , but not IFN-gamma-producing Th1, to be responsible for bone destruction. Here we summarize the current understanding of osteoclast differentiation and activation in the context of osteoimmunology.
Takayanagi
Hiroshi
H
Tokyo Medical and Dental University, Graduate School, Department of Cell Signaling.
D000818:Animals; D001172:Arthritis, Rheumatoid / Q000276:immunology / Q000473:pathology*; D001842:Bone and Bones / Q000276:immunology / Q000473:pathology*; D002454:Cell Differentiation; D006801:Humans; D020381:Interleukin-17 / Q000096:biosynthesis; D008213:Lymphocyte Activation; D010010:Osteoclasts / Q000166:cytology*; D053245:RANK Ligand / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D016176:T-Lymphocyte Subsets / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology
D020381:Interleukin-17; D053245:RANK Ligand