Enantioselective oxidation of O-methyl-N-hydroxylamines using monoamine oxidase N as catalyst.
Enantioselective oxidation of racemic O-methyl-N-hydroxycyclohexylethylamine, using a variant of monoamine oxidase N (MAO-N) from Aspergillus niger, yields unreacted (R)-enantiomer (e.e. = 99%) together with the oxime exclusively in the (E)-configuration.
Eve
Tom S C
TS
School of Chemistry, University of Edinburgh, King's Buildings, West Mains Road, Edinburgh, UK.
Wells
Andrew
A
Turner
Nicholas J
NJ
D001234:Aspergillus niger / Q000201:enzymology*; D002384:Catalysis; D005656:Fungal Proteins / Q000737:chemistry*; D006898:Hydroxylamines / Q000737:chemistry*; D008995:Monoamine Oxidase / Q000737:chemistry*; D010084:Oxidation-Reduction; D013237:Stereoisomerism; D013379:Substrate Specificity
D005656:Fungal Proteins; D006898:Hydroxylamines; C005214:methoxyamine; D008995:Monoamine Oxidase