[Effect of milk basic protein on rat bone mineral density].
OBJECTIVE
To investigate the effect of milk basic protein (MBP)'s on bone mineral density (BMD) and hemobiochemical indexes in normal and ovariectomized (ovx) rats.


METHODS
48 female Sprague-Dawley rats were ovariectomized and another 12 rats received a sham operation (sham). The ovx rats were randomly separated into 4 groups: ovx control, ovx low-does, ovx media dose, and ovx high-dose while 44 normal SD female rats into 4 groups: normal control, normal low-dose, normal media-dose, and normal high-dose. MBP at 10, 20 and 30 mg/(kg x d) were applied in rat diet for continuous 90 days. BMD (at proximal, middle of diaphysis, and distal end) and bone mineral content (BMC) was measured by dual energy X-ray absorptiomery. In addition, serum total protein (TP), total cholesterol (CHO), glucose (GLU) were determined.


RESULTS
The bone density and mineral composition at distant end of femur in low-dosage BMP group were significantly higher than those in normal control group, while no significant change of bone density was observed with MBP treatment in ovx groups. Total serum protein level and albumin level were significantly higher in MBP treatment groups than those in normal control group.


CONCLUSIONS
MBP at 10 mg/kg bw significantly elevated femoral distant-end bone density, as well as the total blood protein level and albumin level in normal rat. However, similar effect was not observed in ovx rat.
Lu
Yu
Y
Department of Food and Nutritional Health, College of Public Health, Beijing University Medical School, Beijing.
Chai
Weizhong
W
Lin
Xiaoming
X
D000818:Animals; D015519:Bone Density / Q000187:drug effects*; D001862:Bone Resorption / Q000517:prevention & control; D005260:Female; D008894:Milk Proteins / Q000494:pharmacology*; D010024:Osteoporosis / Q000378:metabolism / Q000517:prevention & control*; D010052:Ovariectomy; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
D008894:Milk Proteins