title: Bioactive constituents from the marine crinoid Himerometra magnipinna.
abstract: A new tetrabromospirocyclohexadienylisoxazole, (+)-12-hydroxyhomoaerothionin (1), together with the known compounds (+)-aerothionin (2) and crinemodin-rhodoptilometrin bianthrone (3), were isolated from the marine crinoid Himerometra magnipinna, which had been collected in the South China Sea, Malaysia. The structure of 1 was elucidated by interpretation of 1D 1H and 13C NMR spectra and 2D 1H-1H COSY, HMQC, and HMBC spectra. This is the first report of tetrabromospirocyclohexadienylisoxazole compounds from a crinoid of Himerometra. Compounds 1-3 were evaluated for their inhibitory activity with the hyphae formation inhibition assay in Streptomyces 85E.
authors.affiliation: Department of Chemistry and Biochemistry, College of Science and Engineering, University of Minnesota Duluth, 1039 University Drive, Duluth, Minnesota 55812, USA.
authors.forename: Nan
authors.initials: N
authors.lastname: Shao
authors.forename: Guangmin
authors.initials: G
authors.lastname: Yao
authors.forename: Leng Chee
authors.initials: LC
authors.lastname: Chang
mesh_terms: D000818:Animals; D004447:Echinodermata / Q000737:chemistry*; D008296:Malaysia; D008386:Marine Biology; D015394:Molecular Structure; D013141:Spiro Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013302:Streptomyces / Q000187:drug effects*
chemical_list: D013141:Spiro Compounds