Relationship between cytokine response and temporary ventilation during one-lung ventilation in esophagectomy.
OBJECTIVE
Postoperative pulmonary complications are often fatal in patients with esophageal cancer. The aim of this study was to clarify the association between cytokines and temporary ventilation during one-lung ventilation.


METHODS
Serum and BALF IL-6, 8 were measured in 39 patients with esophageal cancer, and the relationship between cytokine response and temporary ventilation during one-lung ventilation in esophagectomy was examined.


RESULTS
Pulmonary complications did not occur in our patients. Serum IL-6 levels were significantly increased in the high one-lung ventilation ratio and long-term one-lung ventilation groups. Serum IL-6 levels in the one or more times ventilation group during one-lung ventilation were significantly low compared to the no-ventilation group. There were no significant differences in serum IL-8 and BALF IL-6, 8 levels.


CONCLUSIONS
Our results indicate that it is important to ventilate one or more times during one-lung ventilation in order to reduce postoperative pulmonary complications.
Ojima
Hitoshi
H
Department of General Surgical Science, Gunma University Faculty of Medicine, Maebashi, Japan. hojima@showa.gunma-u.ac.jp
Kuwano
Hiroyuki
H
Kato
Hiroyuki
H
Miyazaki
Tatsuya
T
Nakajima
Masanobu
M
Sohda
Makoto
M
Tsukada
Katsuhiko
K
D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry; D004938:Esophageal Neoplasms / Q000601:surgery*; D016629:Esophagectomy; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000032:analysis / Q000097:blood; D016209:Interleukin-8 / Q000032:analysis / Q000097:blood; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000517:prevention & control; D012121:Respiration, Artificial / Q000379:methods
D015850:Interleukin-6; D016209:Interleukin-8