The role of protective effects of proline-containing peptides (PGP, PG, and GP) in contractile dysfunction of mesenteric lymphatic vessels in rats with experimental acute peritonitis.
The development of acute peritonitis in rats induced by intraperitoneal injection of thioglycollate was accompanied by a decrease in contractile function of mesenteric lymphatic vessels and impaired response to norepinephrine. Administration of proline-containing peptides after induction of inflammation significantly decreased the severity of these disorders. Our results attest to the possibility of using peptides for the correction of mesenteric microcirculatory disturbances during inflammation.
Umarova
B A
BA
Department of Human and Animal Physiology, Biological Faculty, M. V. Lomonosov Moscow State University.
Lelekova
T V
TV
Kopylova
G N
GN
Goncharova
E L
EL
Bakaeva
Z V
ZV
Samonina
G E
GE
D000208:Acute Disease; D000818:Animals; D007274:Injections, Intraperitoneal; D007700:Kinetics; D042601:Lymphatic Vessels / Q000503:physiopathology*; D008643:Mesentery / Q000098:blood supply* / Q000503:physiopathology; D010455:Peptides / Q000008:administration & dosage / Q000627:therapeutic use*; D010538:Peritonitis / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D011392:Proline / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D020011:Protective Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats; D013864:Thioglycolates / Q000633:toxicity
D010455:Peptides; D020011:Protective Agents; D013864:Thioglycolates; D011392:Proline