Syndrome of inappropriate antidiuretic hormone secretion and ectopic ACTH production in small cell lung carcinoma.
BACKGROUND
Small cell lung carcinoma (SCLC) is frequently associated with a paraneoplastic syndrome.


METHODS
We report on a rare case of SCLC presenting with syndrome of inappropriate antidiuretic hormone (SIADH) secretion and ectopic ACTH production. In accordance with the endocrine evaluation, immunohistochemical staining of the tumour was positive for ADH and ACTH. Chemotherapy with etoposide and carboplatin induced a nearly complete remission.


CONCLUSIONS
Simultaneous secretion of ADH and ACTH is infrequently reported with only five cases described in the literature. SIADH in patients with ectopic ACTH syndrome may be underdiagnosed due to the antagonistic hormone actions of cortisol and ADH on renal sodium excretion.
Müssig
Karsten
K
Horger
Marius
M
Häring
Hans-Ulrich
HU
Wehrmann
Manfred
M
D000182:ACTH Syndrome, Ectopic / Q000150:complications* / Q000209:etiology; D000324:Adrenocorticotropic Hormone / Q000096:biosynthesis* / Q000097:blood; D000970:Antineoplastic Agents / Q000008:administration & dosage; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D016190:Carboplatin / Q000008:administration & dosage; D018288:Carcinoma, Small Cell / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000378:metabolism; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007177:Inappropriate ADH Syndrome / Q000150:complications*; D008175:Lung Neoplasms / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000378:metabolism; D008875:Middle Aged; D011859:Radiography; D012074:Remission Induction
D000970:Antineoplastic Agents; D000972:Antineoplastic Agents, Phytogenic; D005047:Etoposide; D000324:Adrenocorticotropic Hormone; D016190:Carboplatin