Effects of L-, D-, and DL-carnitine on morphometric parameters of skeletal muscle and exercise performance of laboratory animals receiving carnitine-deficient diet.
Serum concentration of L-carnitine, the mean thickness of the skeletal muscle fiber, and exercise performance in the forced swimming test decreased in rats receiving a carnitine-deficient diet. Treatment with L-carnitine compensated for carnitine deficiency, while racemate and D-stereoisomer did not increase its level. L-Carnitine, but not racemate and D-stereoisomer, promoted recovery of the skeletal muscle fiber thickness and exercise performance of rats.
Spasov
A A
AA
Institute of Pharmacology, Volgograd State Medical University. farm@interdacom.ru
Iezhitsa
I N
IN
Kravchenko
M S
MS
Pisarev
V B
VB
Snigur
G L
GL
D000818:Animals; D002331:Carnitine / Q000172:deficiency* / Q000494:pharmacology*; D008297:Male; D023421:Models, Animal; D018482:Muscle, Skeletal / Q000187:drug effects / Q000502:physiology*; D010805:Physical Conditioning, Animal; D051381:Rats; D013237:Stereoisomerism; D013550:Swimming
D002331:Carnitine