title: SMC proteins, new players in the maintenance of genomic stability.
abstract: Homologous recombination (HR) is one of the key mechanisms responsible for the repair of DNA double-strand breaks (DSBs), including those that occur during DNA replication. Recent studies in yeast and mammals have uncovered that the SMC complexes cohesins and Smc5-Smc6 are recruited to induced DSBs, and play a role in the maintenance of genome stability by favouring SCR as the main recombinational DSB repair mechanism. These new results raise intriguing questions such as whether SMC proteins might play a functional role at collapsed replication forks, which may represent the main source of spontaneous recombinogenic damage. A deeper knowledge of the role of SMC proteins in DSB repair should contribute to a better understanding of chromosome dynamics and stability.
authors.affiliation: Department of Molecular Biology, CABIMER, CSIC-Universidad de Sevilla, Sevilla, Spain.
authors.forename: Felipe
authors.initials: F
authors.lastname: Cortés-Ledesma
authors.forename: Giaccomo
authors.initials: G
authors.lastname: de Piccoli
authors.forename: James E
authors.initials: JE
authors.lastname: Haber
authors.forename: Luis
authors.initials: L
authors.lastname: Aragón
authors.forename: Andrés
authors.initials: A
authors.lastname: Aguilera
mesh_terms: D000818:Animals; D018797:Cell Cycle Proteins / Q000502:physiology*; D002868:Chromosomal Proteins, Non-Histone / Q000502:physiology*; D042822:Genomic Instability / Q000235:genetics*; D006801:Humans; D008954:Models, Biological; D009687:Nuclear Proteins / Q000502:physiology*; D012854:Sister Chromatid Exchange / Q000502:physiology; D014981:Xenopus; D015003:Yeasts; D000097722:Cohesins
chemical_list: D018797:Cell Cycle Proteins; D002868:Chromosomal Proteins, Non-Histone; D009687:Nuclear Proteins; D000097722:Cohesins