title: A role for genetics in the immune response to the varicella vaccine.
abstract: BACKGROUND
  A wide range in antibody titers has been found after immunization with the varicella vaccine, although the basis for these differences has not been described.
  
  
  METHODS
  To evaluate the contribution of a genetic component in the immune response to the varicella vaccine, concordance for six-week postimmunization antibody titers was evaluated among 248 biologic siblings who participated in varicella vaccine clinical trials by comparing all pairs of siblings (151 pairs) to all possible unrelated, nonsibling pairs created from within this same cohort (30,477 pairs).
  
  
  RESULTS
  Postimmunization antibody titers after 1 varicella vaccine dose were within the range observed historically among healthy vaccinees, with 85.4% of subjects having antibody responses greater than the approximate correlate of protection of 5 gpELISA units. Postimmunization antibody titers within sibling pairs clustered together more than or less than 10 gpELISA units when compared with within nonsibling pairs (P < 0.0001). Postimmunization titers within sibling pairs were also quantitatively closer together than were those within unrelated, nonsibling pairs (P = 0.022). The age-adjusted intraclass correlation coefficient indicated that the heritability of the varicella vaccine immune response is 45% (95% confidence interval of 15-75%).
  
  
  CONCLUSIONS
  Similarities in siblings' response to varicella vaccine are supportive of the hypothesis that genetic factors play a role in the antibody response to the varicella vaccine.
authors.affiliation: Kaiser Permanente Vaccine Study Center and Division of Research, Oakland, CA 94612, USA. nicola.klein@kp.org
authors.forename: Nicola P
authors.initials: NP
authors.lastname: Klein
authors.forename: Bruce
authors.initials: B
authors.lastname: Fireman
authors.forename: Andrea
authors.initials: A
authors.lastname: Enright
authors.forename: Paula
authors.initials: P
authors.lastname: Ray
authors.forename: Steven
authors.initials: S
authors.lastname: Black
authors.forename: Cornelia L
authors.initials: CL
authors.lastname: Dekker
mesh_terms: D000914:Antibodies, Viral / Q000097:blood*; D002644:Chickenpox / Q000235:genetics* / Q000276:immunology / Q000517:prevention & control*; D019433:Chickenpox Vaccine / Q000008:administration & dosage / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D004200:Diseases in Twins / Q000235:genetics / Q000276:immunology / Q000517:prevention & control; D005260:Female; D020022:Genetic Predisposition to Disease; D014645:Herpesvirus 3, Human / Q000276:immunology*; D006801:Humans; D007223:Infant; D008297:Male; D035781:Siblings; D014427:Twins; D014611:Vaccination
chemical_list: D000914:Antibodies, Viral; D019433:Chickenpox Vaccine