Rhodnius prolixus Malpighian tubules and control of diuresis by neurohormones.
Rhodnius prolixus Malpighian tubules (MTs) are a good model for fluid and ion secretion studies in view of the dramatic postprandial diuresis, which follows its massive blood meals. Ingestion of a blood meal equals to 10-12 times their initial body mass, leads to rapid activation of high output by excretory system, which eliminates 40-50% of the fluid mass. Secretion of ions and water is stimulated 1000-fold by serotonin and diuretic hormone. These hormones cooperate synergistically to activate adenylate cyclase activity from MTs cells, which increase the level of intracellular cAMP. The anti-diuretic hormones have also an important role in the fluid maintenance of Rhodnius prolixus. Several hours after insect feeding occurs a reduction in urine flow, that has been thought to result from a decreased diuretic hormone release or from a novel mechanism of anti-diuresis involving insect cardioacceleratory peptide 2b (CAP2b) and cyclic GMP. In this article it is discussed how the hormone regulation of fluid transport is done in Rhodnius prolixus MTs.
Martini
Sabrina V
SV
CCS, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, 21949-900, Brasil.
Nascimento
Suzete B
SB
Morales
Marcelo M
MM
D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism; D004231:Diuresis / Q000502:physiology*; D007301:Insect Hormones / Q000378:metabolism*; D017136:Ion Transport / Q000502:physiology; D007705:Kinins / Q000378:metabolism; D008317:Malpighian Tubules / Q000378:metabolism / Q000502:physiology*; D009479:Neuropeptides / Q000378:metabolism; D012239:Rhodnius / Q000378:metabolism / Q000502:physiology*; D012701:Serotonin / Q000378:metabolism
D007301:Insect Hormones; D007705:Kinins; D009479:Neuropeptides; C058620:crustacean cardioactive peptide; D012701:Serotonin; D000324:Adrenocorticotropic Hormone; D000242:Cyclic AMP