title: Prevention and treatment of aortic graft infection.
abstract: Prosthetic vascular graft infection remains one of the most challenging surgical problems for vascular surgeons. This condition is classically associated with high morbidity and mortality rates. Accurate diagnosis of a vascular graft infection can typically be made based on a thorough history and physical examination; although, infrequently, an extensive radiological evaluation is necessary to establish the clinical finding. Complete graft excision and extra-anatomic bypass grafting remains a commonly accepted surgical treatment strategy. Recent clinical data have supported other treatment modalities, including the use of in situ antibiotic-impregnated graft replacement, in situ allograft replacement and in situ autologous graft replacement. This article will review the pathobiology of aortic graft infection, as well as methods to prevent a prosthetic graft infection. Furthermore, various surgical treatment modalities of aortic graft infection will be discussed.
authors.affiliation: The Michael E DeBakey VA Medical Center, Division of Vascular Surgery & Endovascular Therapy, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX, USA. fmussa@bcm.edu
authors.forename: Firas F
authors.initials: FF
authors.lastname: Mussa
authors.forename: Nasim
authors.initials: N
authors.lastname: Hedayati
authors.forename: Wei
authors.initials: W
authors.lastname: Zhou
authors.forename: Hosam F
authors.initials: HF
authors.lastname: El-Sayed
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Kougias
authors.forename: Rabih O
authors.initials: RO
authors.lastname: Darouiche
authors.forename: Peter H
authors.initials: PH
authors.lastname: Lin
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use; D001011:Aorta / Q000382:microbiology / Q000637:transplantation*; D001424:Bacterial Infections / Q000188:drug therapy / Q000209:etiology / Q000517:prevention & control*; D006801:Humans; D019737:Transplants / Q000009:adverse effects / Q000382:microbiology; D014656:Vascular Surgical Procedures / Q000009:adverse effects
chemical_list: D000900:Anti-Bacterial Agents