Kleine-Levin syndrome: interface between neurology and psychiatry.
We report the first episode of Kleine-Levin (KLS) syndrome in a 17-year-old male. The illness onset, clinical features, neuropsychological evaluation and polysomnographic recording are described. Typical symptoms hypersomnia, hyperphagia and sexual disinhibition were observed besides behavioral disturbances, polysomnographic and neuropsychological alterations. Behavioral disturbances similar to a manic episode including psychotic symptoms were relevant. The pharmacologic treatment included lithium, methylphenidate and risperidone. The introduction of risperidone aimed the control of psychotic symptoms and the persistent manifestations of hypersexuality after sleepiness control and to the best of our knowledge there are no other reports regarding risperidone use for KLS in the literature.
Justo
Luís Pereira
LP
Department of Psychobiology, Federal University of São Paulo, 01333-000 São Paulo, SP, Brazil. luisjusto1@ig.com.br
Calil
Helena Maria
HM
Prado-Bolognani
Sílvia A
SA
Muszkat
Mauro
M
D000293:Adolescent; D014150:Antipsychotic Agents / Q000627:therapeutic use; D006801:Humans; D017593:Kleine-Levin Syndrome / Q000175:diagnosis* / Q000188:drug therapy; D018020:Lithium Compounds / Q000627:therapeutic use; D008297:Male; D008774:Methylphenidate / Q000627:therapeutic use; D009483:Neuropsychological Tests; D017286:Polysomnography; D018967:Risperidone / Q000627:therapeutic use
D014150:Antipsychotic Agents; D018020:Lithium Compounds; D008774:Methylphenidate; D018967:Risperidone