Inappropriate use of potent topical glucocorticoids in infants.
Topical therapy with glucocorticoids (GCs) is used commonly in chronic dermatoses. Side effects are less common compared to systemic use; however, newer potent preparations may have serious side effects. A potential danger is their inappropriate use. Three infants who developed iatrogenic Cushing's syndrome and prolonged adrenal suppression in the course of GC therapy for simple diaper dermatitis are described. One patient also developed steatohepatitis which is uncommon with local GCs.
Ozon
Alev
A
Department of Pediatrics, Division of Endocrinology, Medical Faculty, Hacettepe University, Ihsan Dogramaci Children's Hospital, Ankara, Turkey. zeynepa@hacettepe.edu.tr
Cetinkaya
Semra
S
Alikasifoglu
Ayfer
A
Gonc
E Nazli
EN
Sen
Yaşar
Y
Kandemir
Nurgün
N
D000287:Administration, Topical; D000075202:Contraindications; D003480:Cushing Syndrome / Q000139:chemically induced* / Q000175:diagnosis; D003872:Dermatitis / Q000188:drug therapy*; D003937:Diagnosis, Differential; D005234:Fatty Liver / Q000139:chemically induced / Q000175:diagnosis; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects / Q000503:physiopathology; D007049:Iatrogenic Disease; D007223:Infant; D009765:Obesity / Q000175:diagnosis; D010913:Pituitary-Adrenal System / Q000187:drug effects / Q000503:physiopathology
D005938:Glucocorticoids