title: Metabolic activity of cells in brain cortex after alcohol intoxication and correction of changes with Dolivin.
abstract: Metabolic processes in the brain cortex of albino rats with prenatal and postnatal alcohol intoxication were studied by the method of electron paramagnetic resonance. Accumulation of superoxide radical-generating agents, inactivation of superoxide dismutase, and increase in nitric oxide concentration were detected. Activation of free radical processes was associated with accumulation of Mn(2+)and Fe(2+). The parameters of electron paramagnetic resonance returned to normal after Dolivin treatment. These changes were accompanied by a decrease in the intensity of oxidative metabolism.
authors.affiliation: I. S. Beritashvili Institute of Physiology, Georgian Academy of Sciences; Institute of Clinical and Experimental Medicine, Georgian State Medical University, Tbilisi. nanajaparidze2000@yahoo.com
authors.forename: D P
authors.initials: DP
authors.lastname: Museridze
authors.forename: T V
authors.initials: TV
authors.lastname: Sanikidze
authors.forename: I K
authors.initials: IK
authors.lastname: Svanidze
mesh_terms: D000435:Alcoholic Intoxication / Q000378:metabolism*; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D002540:Cerebral Cortex / Q000166:cytology / Q000378:metabolism*; D004578:Electron Spin Resonance Spectroscopy; D005260:Female; D010647:Phenyl Ethers / Q000737:chemistry*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000378:metabolism; D051381:Rats; D012441:Saccharomyces cerevisiae / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D010647:Phenyl Ethers; C085806:olifen