title: Endonasal endoscopic resection and radiotherapy in olfactory neuroblastoma: our experience.
abstract: BACKGROUND
  Our aim was to evaluate the efficacy of a bimodal method of treatment consisting in endoscopic resection followed by radiotherapy in patients with olfactory neuroblastoma (ON).
  
  
  METHODS
  This is a retrospective review on 10 patients with ON treated at a tertiary referral center. All the patients were treated with endonasal endoscopic resection, and 1 refused postoperative radiotherapy.
  
  
  RESULTS
  No mortality was observed. Local tumor control was obtained in all the patients. Follow-up ranged from 15 to 79 months (median, 37 months). One patient developed a regional recurrence and for this was treated with bilateral, modified type III radical neck dissection plus radiotherapy on the neck. All patients regained a good quality of life after the treatment.
  
  
  CONCLUSIONS
  This method of treatment causes minimal injury to the patients, reduces side effects, and improves the quality of life of those with olfactory neuroblastoma.
authors.affiliation: Department of Otorhinolaryngology, University of Insubria, Varese, Azienda Ospedaliero Universitaria Ospedale di Circolo e Fondazione Macchi, Varese, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Castelnuovo
authors.forename: Maurizio
authors.initials: M
authors.lastname: Bignami
authors.forename: Giovanni
authors.initials: G
authors.lastname: Delù
authors.forename: Paolo
authors.initials: P
authors.lastname: Battaglia
authors.forename: Mario
authors.initials: M
authors.lastname: Bignardi
authors.forename: Iacopo
authors.initials: I
authors.lastname: Dallan
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D004724:Endoscopy / Q000379:methods*; D018304:Esthesioneuroblastoma, Olfactory / Q000532:radiotherapy* / Q000601:surgery*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009296:Nasal Cavity; D009669:Nose Neoplasms / Q000532:radiotherapy* / Q000601:surgery*; D011788:Quality of Life; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies