Novel aminoethylbiphenyls as 5-HT7 receptor ligands.
The synthesis of a series of aminoethylbiphenyls as novel 5-HT(7) receptor ligands is described. The novel derivatives exhibit high affinity for the 5-HT(7) receptor with selectivity toward 5-HT(1A) receptor.
Paillet-Loilier
Magalie
M
Centre d'Etudes et de Recherche sur le Médicament de Normandie EA3915, Université de Caen, UFR des Sciences Pharmaceutiques, 5, rue Vaubénard 14032 Caen Cedex, France.
Fabis
Frédéric
F
Lepailleur
Alban
A
Bureau
Ronan
R
Butt-Gueulle
Sabrina
S
Dauphin
François
F
Lesnard
Aurélien
A
Delarue
Catherine
C
Vaudry
Hubert
H
Rault
Sylvain
S
D000611:Aminobiphenyl Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D000818:Animals; D006801:Humans; D008024:Ligands; D051381:Rats; D011985:Receptors, Serotonin / Q000737:chemistry* / Q000187:drug effects
D000611:Aminobiphenyl Compounds; D008024:Ligands; D011985:Receptors, Serotonin; C104425:serotonin 7 receptor