Noninvasive identification of different intraocular lenses using Raman spectroscopy in porcine eyes.
OBJECTIVE
To develop a noninvasive technique for identifying the specific type of intraocular lens (IOL) implanted in porcine eyes.


METHODS
Department of Ophthalmology, University of Ulsan College of Medicine, Asan Medical Center, and Department of Chemistry Education, Seoul National University, Seoul, Korea.


METHODS
A confocal Raman spectroscopy system was used to identify various acrylic (AcrySof SA60AT [Alcon], Sensar AR40e [Advanced Medical Optics], I-Flex [I-Medical Intraocular Lenses]) and silicone (ClariFlex, [Advanced Medical Optics]) IOLs implanted in enucleated pig eyes. Confocal Raman spectra of IOLs were obtained by photoexcitation using the 514.5 nm line from an argon-ion laser, with a power of 1 mW at the sample and an acquisition time of 10 to 100 seconds.


RESULTS
All IOLs, including those composed of acrylic optic material from different manufacturers, exhibited distinct spectral peaks before and after implantation in pig eyes.


CONCLUSIONS
Confocal Raman spectroscopy may represent a novel method for obtaining specific information about implanted IOLs through direct and noninvasive confocal observation of spectral characteristics.
Hwang
Jong-uk
JU
Department of Ophthalmology, University of Ulsan College of Medicine, Asan Medical Center, Songpa-Gu, Seoul, Korea.
Choi
Heejeong
H
Jeong
Dae Hong
DH
Kim
Myoung Joon
MJ
Tchah
Hungwon
H
D000180:Acrylic Resins / Q000737:chemistry*; D000818:Animals; D019654:Lens Implantation, Intraocular; D007908:Lens, Crystalline / Q000601:surgery; D007910:Lenses, Intraocular; D013059:Spectrum Analysis, Raman; D013552:Swine
D000180:Acrylic Resins