Post-transcriptional control of the interferon system.
The interferon (IFN) system is a well-controlled network of signaling, transcriptional, and post-transcriptional processes that orchestrate host defense against microbes. The IFN response comprises a multi-array of IFN-stimulated gene products that mediate a variety of biological processes designed to control infection and regulate specific immune responses. In this review, we focus on post-transcriptional mechanisms of gene regulation that occur during the course of IFN induction and during the response of cells to IFN. Post-transcriptional mechanisms involve different levels of regulation such as mRNA stability, alternative splicing, and translation. Such controls offer a fine tuning mechanism for efficient and rapid response and as a negative feedback control in IFN biosynthesis and response.
Khabar
Khalid S A
KS
Program in BioMolecular Research, King Faisal Specialist Hospital and Research Center, P3354, MBC-03, Takhasusi Road, Riyadh 11211, Saudi Arabia. khabar@kfshrc.edu.sa
Young
Howard A
HA
D020413:3' Untranslated Regions; D000818:Animals; D001483:Base Sequence; D004722:Endoribonucleases / Q000378:metabolism; D025461:Feedback, Physiological; D006801:Humans; D016899:Interferon-beta / Q000378:metabolism; D007371:Interferon-gamma / Q000378:metabolism; D007372:Interferons / Q000096:biosynthesis / Q000737:chemistry / Q000378:metabolism*; D008954:Models, Biological; D008969:Molecular Sequence Data; D012323:RNA Processing, Post-Transcriptional; D015398:Signal Transduction; D014158:Transcription, Genetic; D019892:eIF-2 Kinase / Q000378:metabolism
D020413:3' Untranslated Regions; D016899:Interferon-beta; D007371:Interferon-gamma; D007372:Interferons; D019892:eIF-2 Kinase; D004722:Endoribonucleases; C031956:2-5A-dependent ribonuclease