Outcome of in vitro fertilization treatment in infertile women conservatively treated for endometrial adenocarcinoma.
OBJECTIVE
To evaluate IVF characteristics and outcome of infertile women conservatively treated for well-differentiated endometrial adenocarcinoma.


METHODS
Observational case series study.


METHODS
The Department of Gynecology Oncology and IVF unit of Chaim Sheba Medical center, Tel-Hashomer, Israel.


METHODS
Eight women referred to IVF treatment because of failure of other fertility treatments after conservative treatment of endometrial adenocarcinoma. All women were selected carefully for conservative treatment at the Department of Gynecology Oncology of the Chaim Sheba Medical Center after a thorough metastatic workup.


METHODS
In vitro fertilization/intracytoplasmic sperm injection treatment.


METHODS
Serum E(2) levels at hCG administration, endometrial thickness, number of oocytes retrieved, fertilization rate, pregnancy and delivery rate.


RESULTS
All women were nulliparous before IVF treatment, and only one woman was older than 35 years. In four of them, endometrial adenocarcinoma was diagnosed during infertility workup or treatment. A total of 31 IVF cycles were performed. The mean number of oocytes retrieved was 9.4 (95% confidence interval, 5.1-13.6), and fertilization rate was 58.6%. Six women (75%) conceived, and four (50%) delivered six healthy offspring.


CONCLUSIONS
In vitro fertilization treatment of infertile women conservatively treated for well-differentiated endometrial adenocarcinoma is highly successful and offers the opportunity to cryopreserve embryos for future use.
Elizur
Shai E
SE
IVF Unit, Tel-Hashomer, Israel. shai.elizur@muhc.mcgill.ca
Beiner
Mario E
ME
Korach
Jacob
J
Weiser
Amir
A
Ben-Baruch
Gilad
G
Dor
Jehoshua
J
D000230:Adenocarcinoma / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D000328:Adult; D016022:Case-Control Studies; D015331:Cohort Studies; D016889:Endometrial Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007247:Infertility, Female / Q000209:etiology / Q000628:therapy*; D009364:Neoplasm Recurrence, Local; D011247:Pregnancy; D018873:Pregnancy Rate; D011372:Progestins / Q000627:therapeutic use*; D012189:Retrospective Studies; D016896:Treatment Outcome
D011372:Progestins