Interaction between 5-HT1A and BDNF genotypes increases the risk of treatment-resistant depression.
Several studies have linked 5-HT1A C1019G and BDNF G196A (Val66Met) gene polymorphisms to major depressive disorder (MDD) and the actions of antidepressants. We attempt to show that the interaction between 5-HT1A and BDNF polymorphism predicts the risk of treatment-resistant depression. The sample consists of 119 patients with treatment-resistant MDD and 392 controls. 5-HT1A C1019G and BDNF G196A (Val66Met) polymorphisms were studied. The combination of 5-HT1A GG and BDNF GA + AA genotypes is associated with an increased risk of depression.
Anttila
S
S
Medical School, University of Tampere, Tampere, Finland. samia@koti.soon.fi
Huuhka
K
K
Huuhka
M
M
Rontu
R
R
Hurme
M
M
Leinonen
E
E
Lehtimäki
T
T
D000328:Adult; D000368:Aged; D000928:Antidepressive Agents / Q000494:pharmacology; D001921:Brain / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology; D001923:Brain Chemistry / Q000187:drug effects* / Q000235:genetics; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D004252:DNA Mutational Analysis; D003866:Depressive Disorder / Q000235:genetics* / Q000378:metabolism / Q000628:therapy; D004351:Drug Resistance / Q000235:genetics*; D004565:Electroconvulsive Therapy / Q000706:statistics & numerical data; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005820:Genetic Testing; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics; D044282:Receptor, Serotonin, 5-HT1A / Q000235:genetics*; D012307:Risk Factors; D012701:Serotonin / Q000378:metabolism; D017211:Treatment Failure
D000928:Antidepressive Agents; D019208:Brain-Derived Neurotrophic Factor; D005819:Genetic Markers; D044282:Receptor, Serotonin, 5-HT1A; D012701:Serotonin