title: Kleine-Levin syndrome: interface between neurology and psychiatry.
abstract: We report the first episode of Kleine-Levin (KLS) syndrome in a 17-year-old male. The illness onset, clinical features, neuropsychological evaluation and polysomnographic recording are described. Typical symptoms hypersomnia, hyperphagia and sexual disinhibition were observed besides behavioral disturbances, polysomnographic and neuropsychological alterations. Behavioral disturbances similar to a manic episode including psychotic symptoms were relevant. The pharmacologic treatment included lithium, methylphenidate and risperidone. The introduction of risperidone aimed the control of psychotic symptoms and the persistent manifestations of hypersexuality after sleepiness control and to the best of our knowledge there are no other reports regarding risperidone use for KLS in the literature.
authors.affiliation: Department of Psychobiology, Federal University of São Paulo, 01333-000 São Paulo, SP, Brazil. luisjusto1@ig.com.br
authors.forename: Luís Pereira
authors.initials: LP
authors.lastname: Justo
authors.forename: Helena Maria
authors.initials: HM
authors.lastname: Calil
authors.forename: Sílvia A
authors.initials: SA
authors.lastname: Prado-Bolognani
authors.forename: Mauro
authors.initials: M
authors.lastname: Muszkat
mesh_terms: D000293:Adolescent; D014150:Antipsychotic Agents / Q000627:therapeutic use; D006801:Humans; D017593:Kleine-Levin Syndrome / Q000175:diagnosis* / Q000188:drug therapy; D018020:Lithium Compounds / Q000627:therapeutic use; D008297:Male; D008774:Methylphenidate / Q000627:therapeutic use; D009483:Neuropsychological Tests; D017286:Polysomnography; D018967:Risperidone / Q000627:therapeutic use
chemical_list: D014150:Antipsychotic Agents; D018020:Lithium Compounds; D008774:Methylphenidate; D018967:Risperidone