Attenuated aerobic exercise capacity in CD36 deficiency.
BACKGROUND
An important role of CD36 in muscle fatty acid (FA) uptake has been shown in CD36-knockout or CD36-overexpressed mice. FA is a predominant substrate in energy production during light exercise below the anaerobic threshold (AT). We studied whether aerobic exercise capacity in humans could be affected by CD36 deficiency.


METHODS
We investigated the ventilatory threshold (VT) and serum FA changes in normal participants (n = 22) and participants with CD36 deficiency (n = 12) during pedalling on a cycle ergometer.


RESULTS
In participants with CD36 deficiency, FA levels were not reduced at peak work rate, whereas FA levels decreased by about 50% in normal participants. Participants with CD36 deficiency showed significantly lower VT than normal participants. A significant correlation was observed between VT and percentage changes in FA at peak work rate.


CONCLUSIONS
This study found reduced FA utilisation and an attenuated aerobic exercise capacity in CD36 deficiency, indicating that CD36-mediated FA oxidation is an important determinant for aerobic exercise capacity in humans.
Yanai
Hidekatsu
H
Department of Laboratory Medicine, Hokkaido University School of Medicine, Sapporo 060-8648, Japan. yanaih@jikei.ac.jp
Watanabe
Ichiro
I
Ishii
Kojiro
K
Morimoto
Mie
M
Fujiwara
Hironobu
H
Yoshida
Shigeru
S
Hui
Shu-Ping
SP
Matsuno
Kazuhiko
K
Chiba
Hitoshi
H
D000328:Adult; D015308:Anaerobic Threshold / Q000235:genetics* / Q000502:physiology; D018955:CD36 Antigens / Q000235:genetics*; D005080:Exercise Test; D005227:Fatty Acids / Q000097:blood; D005260:Female; D005838:Genotype; D006801:Humans; D007564:Japan; D010084:Oxidation-Reduction; D012123:Pulmonary Ventilation
D018955:CD36 Antigens; D005227:Fatty Acids