title: [Therapeutic management of tics in Tourette's syndrome].
abstract: Tourette's syndrome is a neuropsychiatric disorder characterised by both involuntary movements, tics, and psychiatric symptoms, attentional deficit disorder, hyperactivity, obsessive compulsive symptoms..., and can be the cause of major disability. Over the past 30 years, several types of treatment have been proposed for the treatment of tics in Tourette's Syndrome, ranging from psychotherapeutic approaches to neurosurgery. The education of the patient and his entourage is fundamental and must be offered to all patients. Psychotherapy does not directly improve the tics but contributes to a better adjustment of both patient and carers to his disability. The decision to start a course of drug therapy depends largely on the impact of the patient's tics on his personal life. Drug treatment relies on neuromodulators acting on a variety of neural systems and whose efficacy has been rarely demonstrated. The literature shows that the latest generation of dopaminergic antagonists have the highest benefit/risk ratio. Recently, deep brain stimulation, by modulating neuronal activity in structures involved in the pathophysiology of the disease, has become a promising therapeutical approach, producing a marked decrease in the severity of tics over that obtained with other treatments.
authors.affiliation: Centre d'Investigation Clinique, Groupe Hospitalier Pitié-Salpêtrière, Paris, France.
authors.forename: R
authors.initials: R
authors.lastname: Diallo
authors.forename: M L
authors.initials: ML
authors.lastname: Welter
authors.forename: L
authors.initials: L
authors.lastname: Mallet
mesh_terms: D000928:Antidepressive Agents / Q000627:therapeutic use; D018492:Dopamine Antagonists / Q000627:therapeutic use; D006801:Humans; D019635:Neurosurgical Procedures; D011613:Psychotherapy; D005879:Tourette Syndrome / Q000523:psychology / Q000601:surgery / Q000628:therapy*
chemical_list: D000928:Antidepressive Agents; D018492:Dopamine Antagonists