Secondary metabolites from the roots of Engelhardia roxburghiana and their antitubercular activities.
Engelharquinone (1), engelharquinone epoxide (2), engelharolide (3), and engelhardic acid (4), were isolated as naturally occurring products from a plant source, Engelhardia roxburghiana together with 20 previously known compounds, four of which were hitherto not known as plant constituents. Their structures were identified by means of spectroscopic analysis. A biological evaluation showed that three of the previously isolated antitubercular constituents [(-)-4-hydroxy-1-tetralone, 3-methoxyjuglone and engelhardione] and engelharquinone (1) exhibited moderate antitubercular activity against Mycobacterium tuberculosis 90-221387.
Wu
Che-Chen
CC
Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan, ROC.
Peng
Chien-Fang
CF
Tsai
Ian-Lih
IL
Abd El-Razek
Mohamed H
MH
Huang
He-Shun
HS
Chen
Ih-Sheng
IS
D000995:Antitubercular Agents / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology*; D029525:Juglandaceae / Q000737:chemistry / Q000378:metabolism*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D018517:Plant Roots / Q000737:chemistry / Q000378:metabolism*
D000995:Antitubercular Agents