Four cardiac hormones eliminate 4-fold more human glioblastoma cells than the green mamba snake peptide.
Within 24h four cardiac hormones, i.e., vessel dilator, kaliuretic peptide, atrial natriuretic peptide, and long acting natriuretic peptide decrease the number of human glioblastoma cells 75%, 68%, 67%, and 65% while Dendroaspis (green mamba) peptide caused a 17% decrease when each were utilized at 100 microM. The four cardiac hormones decreased DNA synthesis 65-87% and increased cyclic GMP 1.3- to 3.8-fold in the glioblastoma cells. Natriuretic peptide receptors (NPR)-A and -C were present.


CONCLUSIONS
four cardiac hormones eliminate up to 75% of glioblastoma cells via cyclic GMP-mediated up to 87% decrease in DNA synthesis.
Vesely
Brian A
BA
Department of Internal Medicine, James A Haley Veterans Medical Center, Tampa, FL 33612, USA.
Eichelbaum
Ehrentraud J
EJ
Alli
Abdel A
AA
Sun
Ying
Y
Gower
William R
WR
Vesely
David L
DL
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D015153:Blotting, Western; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D004273:DNA, Neoplasm / Q000096:biosynthesis; D004305:Dose-Response Relationship, Drug; D017815:Elapidae / Q000378:metabolism; D005909:Glioblastoma / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D006801:Humans; D009206:Myocardium / Q000737:chemistry / Q000378:metabolism; D010446:Peptide Fragments / Q000494:pharmacology; D010455:Peptides / Q000494:pharmacology*; D011498:Protein Precursors / Q000494:pharmacology*; D017461:Receptors, Atrial Natriuretic Factor / Q000378:metabolism; D013997:Time Factors
D000970:Antineoplastic Agents; D004273:DNA, Neoplasm; D010446:Peptide Fragments; D010455:Peptides; D011498:Protein Precursors; C075322:atrial natriuretic factor precursor (79-98); C054547:atrial natriuretic factor prohormone (1-30), human; C054548:atrial natriuretic factor prohormone (31-67); D009320:Atrial Natriuretic Factor; D017461:Receptors, Atrial Natriuretic Factor