title: Acute myeloid leukemia with the 8q22;21q22 translocation: secondary mutational events and alternative t(8;21) transcripts.
abstract: Nonrandom and somatically acquired chromosomal translocations can be identified in nearly 50% of human acute myeloid leukemias. One common chromosomal translocation in this disease is the 8q22;21q22 translocation. It involves the AML1 (RUNX1) gene on chromosome 21 and the ETO (MTG8, RUNX1T1) gene on chromosome 8 generating the AML1-ETO fusion proteins. In this review, we survey recent advances made involving secondary mutational events and alternative t(8;21) transcripts in relation to understanding AML1-ETO leukemogenesis.
authors.affiliation: Department of Molecular and Experimental Medicine, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
authors.forename: Luke F
authors.initials: LF
authors.lastname: Peterson
authors.forename: Anita
authors.initials: A
authors.lastname: Boyapati
authors.forename: Eun-Young
authors.initials: EY
authors.lastname: Ahn
authors.forename: Joseph R
authors.initials: JR
authors.lastname: Biggs
authors.forename: Akiko Joo
authors.initials: AJ
authors.lastname: Okumura
authors.forename: Miao-Chia
authors.initials: MC
authors.lastname: Lo
authors.forename: Ming
authors.initials: M
authors.lastname: Yan
authors.forename: Dong-Er
authors.initials: DE
authors.lastname: Zhang
mesh_terms: D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000235:genetics* / Q000378:metabolism; D002891:Chromosomes, Human, Pair 21 / Q000235:genetics* / Q000378:metabolism; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics* / Q000378:metabolism; D050676:Core Binding Factor Alpha 2 Subunit / Q000096:biosynthesis / Q000235:genetics*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D051379:Mice; D015514:Oncogene Proteins, Fusion / Q000096:biosynthesis / Q000235:genetics*; D000075142:RUNX1 Translocation Partner 1 Protein; D014158:Transcription, Genetic; D014178:Translocation, Genetic
chemical_list: C107844:AML1-ETO fusion protein, human; D050676:Core Binding Factor Alpha 2 Subunit; D015514:Oncogene Proteins, Fusion; D000075142:RUNX1 Translocation Partner 1 Protein