title: The infectivity and pathogenicity of a group 2 bovine coronavirus in pups.
abstract: Canine respiratory coronavirus (CRCoV), which is more closely related to the bovine coronavirus (BCoV), has recently been detected in dogs. In this study, we examined whether BCoV was capable of infecting and exhibiting pathogenicity in dogs. Three 1-month-old pups were oronasally given field isolates of BCoV, and were kept together with 2 control animals. As a result, increases in BCoV-neutralizing antibody titers were confirmed in all pups in the challenged and control groups. Moreover, the virus gene was also detected in oral and rectal swabs by RT-PCR. These results indicate that BCoV infects dogs, and easily infects other dogs that are kept together. However, no clinical symptoms such as respiratory symptoms and diarrhea were observed.
authors.affiliation: Department of Veterinary Infectious Disease, School of Veterinary Medicine and Animal Science, Kitasato University, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Kaneshima
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Hohdatsu
authors.forename: Ryoko
authors.initials: R
authors.lastname: Hagino
authors.forename: Sakiko
authors.initials: S
authors.lastname: Hosoya
authors.forename: Yui
authors.initials: Y
authors.lastname: Nojiri
authors.forename: Michiko
authors.initials: M
authors.lastname: Murata
authors.forename: Tomomi
authors.initials: T
authors.lastname: Takano
authors.forename: Maki
authors.initials: M
authors.lastname: Tanabe
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tsunemitsu
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Koyama
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D018352:Coronavirus Infections / Q000276:immunology / Q000662:veterinary*; D017938:Coronavirus, Bovine / Q000235:genetics / Q000472:pathogenicity*; D004283:Dog Diseases / Q000276:immunology / Q000821:virology*; D004285:Dogs; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000662:veterinary; D013997:Time Factors
chemical_list: D000914:Antibodies, Viral