Effect of hypoxia during early organogenesis on cardiac activity and noradrenergic regulation in the postnatal period.
Cardiac activity in rats during the postnatal period was studied in vitro and in vivo after exposure of rat pups to antenatal acute hypobaric hypoxia at the stage of organogenesis (day 9-10 of gestation). Cultured cardiomyocytes from rat pups exposed to antenatal hypoxia were characterized by increased rate of contractions and decreased reactivity to norepinephrine. Heart rate elevation, predominance of sympathetic influences on cardiac activity, and significant increase in norepinephrine concentration in the cerebral cortex were found in freely moving animals exposed to antenatal hypoxia. Our results indicate that hypoxia at the stage of organogenesis modulated cardiac activity during the postnatal period, which manifested at the level of effector structures in the heart and activity of regulatory systems.
Graf
A V
AV
Department of Human and Animal Physiology, M. V. Lomonosov Moscow State University, Moscow. stasy_gr@pochta.ru
Maslova
M V
MV
Maklakova
A S
AS
Sokolova
N A
NA
Kudryashova
N Yu
NY
Krushinskaya
Ya V
YV
Goncharenko
E N
EN
Neverova
M E
ME
Fidelina
O V
OV
D000818:Animals; D000831:Animals, Newborn; D002478:Cells, Cultured; D002540:Cerebral Cortex / Q000378:metabolism; D005260:Female; D005311:Fetal Hypoxia / Q000503:physiopathology; D006339:Heart Rate / Q000187:drug effects; D000860:Hypoxia / Q000503:physiopathology*; D009200:Myocardial Contraction / Q000187:drug effects; D032383:Myocytes, Cardiac / Q000187:drug effects / Q000502:physiology*; D009638:Norepinephrine / Q000502:physiology*; D011247:Pregnancy; D011248:Pregnancy Complications; D011297:Prenatal Exposure Delayed Effects; D051381:Rats
D009638:Norepinephrine