title: Polymorphisms of CD1 genes in chronic dysimmune neuropathies.
abstract: CD1 are MCH-like glycoproteins specialized in capturing and presenting glycolipid to T cells. Expression of CD1 molecules has been observed on endoneurial machrophages in patients with chronic inflammatory demyelinating polyneuropathy (CIDP) and vasculitis and polymorphisms of CID1A and CD1E genes have been associated with susceptibility to develop Guillain-Barré syndrome. In 46 patients with CIDP, in 13 patients with multifocal motor neuropathy and in 132 controls we genotyped exon 2 of CD1A and CD1E genes. We found no association between chronic dysimmune neuropathies, with or without anti-ganglioside antibodies, and polymorphisms of CD1A and CD1E genes.
authors.affiliation: Department of Human Motor Sciences University "G. d'Annunzio", Chieti--Pescara, Italy.
authors.forename: Maria Vittoria
authors.initials: MV
authors.lastname: De Angelis
authors.forename: Francesca
authors.initials: F
authors.lastname: Notturno
authors.forename: Christina M
authors.initials: CM
authors.lastname: Caporale
authors.forename: Marta
authors.initials: M
authors.lastname: Pace
authors.forename: Antonino
authors.initials: A
authors.lastname: Uncini
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000906:Antibodies / Q000097:blood; D018949:Antigens, CD1 / Q000235:genetics*; D002648:Child; D005260:Female; D005732:Gangliosides / Q000276:immunology; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011129:Polyradiculoneuropathy / Q000235:genetics*; D020277:Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / Q000097:blood / Q000235:genetics*
chemical_list: D000906:Antibodies; D018949:Antigens, CD1; C419393:CD1a antigen; C417738:CD1e antigen; D005732:Gangliosides