title: Mutation analysis of NANOS3 in 80 Chinese and 88 Caucasian women with premature ovarian failure.
abstract: NANOS3 encodes an RNA-binding protein and has a conserved function in germ cell development. Our objective was to investigate whether mutations in NANOS3 were present in Chinese and Caucasian women with premature ovarian failure. A known synonymous single-nucleotide polymorphism (rs 2016163) in exon 1 was identified through sequencing 80 Chinese and 88 Caucasian women with premature ovarian failure. No additional single-nucleotide polymorphisms or mutations were found in exons encoding for NANOS3. Our findings suggest that mutations in NANOS3 exons are rare in both Chinese and Caucasian women with premature ovarian failure.
authors.affiliation: Center for Reproductive Medicine, Shandong Provincial Hospital, Shandong University, Jinan, China.
authors.forename: Yingying
authors.initials: Y
authors.lastname: Qin
authors.forename: Han
authors.initials: H
authors.lastname: Zhao
authors.forename: Ertug
authors.initials: E
authors.lastname: Kovanci
authors.forename: Joe Leigh
authors.initials: JL
authors.lastname: Simpson
authors.forename: Zi-Jiang
authors.initials: ZJ
authors.lastname: Chen
authors.forename: Aleksandar
authors.initials: A
authors.lastname: Rajkovic
mesh_terms: D000293:Adolescent; D000328:Adult; D044466:Asian People / Q000235:genetics*; D004252:DNA Mutational Analysis / Q000379:methods; D005260:Female; D006801:Humans; D009154:Mutation; D020641:Polymorphism, Single Nucleotide; D016649:Primary Ovarian Insufficiency / Q000235:genetics*; D016601:RNA-Binding Proteins / Q000235:genetics*; D044465:White People / Q000235:genetics*
chemical_list: C524848:NANOS3 protein, human; D016601:RNA-Binding Proteins