Second transplant with two unrelated cord blood units for early graft failure after haematopoietic stem cell transplantation.
Graft failure (GF) can be a fatal complication following haematopoietic stem cell transplantation (HSCT). We report four patients who developed early GF after unrelated HSCT and who subsequently received a double unrelated cord blood transplant (dUCBT) after reduced-intensity conditioning, at a median 15 d after the decision to perform a second transplant. Neutrophil recovery was observed in all four patients between day +15 and +31 with full donor chimaerism of one unit. Acute GVHD grades II-IV was observed in three patients. Three are alive, between 12 and 25 months after dUCBT. In conclusion, dUCBT is a promising procedure to treat early GF.
Fernandes
Juliana
J
Haematology Department and Bone Marrow Transplant Unit, Hôpital Saint Louis, Paris, France.
Rocha
Vanderson
V
Robin
Marie
M
de Latour
Régis Peffault
RP
Traineau
Richard
R
Devergie
Agnès
A
Ribaud
Patricia
P
Réa
Delphine
D
Larghero
Jérôme
J
Gluckman
Eliane
E
Socié
Gérard
G
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000741:Anemia, Aplastic / Q000601:surgery; D002675:Child, Preschool; D036101:Cord Blood Stem Cell Transplantation; D017809:Fatal Outcome; D005260:Female; D005312:Fetal Blood; D006084:Graft Rejection / Q000601:surgery*; D006086:Graft vs Host Disease; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000601:surgery; D007951:Leukemia, Myeloid / Q000601:surgery*; D015473:Leukemia, Promyelocytic, Acute / Q000601:surgery; D008297:Male; D012086:Reoperation; D018183:Transplantation Chimera; D019172:Transplantation Conditioning / Q000379:methods