Inhibition of monosodium urate monohydrate-mediated hemolysis by vitamin E.
Microcrystals of monosodium urate monohydrate (MSUM) induce cytolysis and hemolysis in erythrocytes. In this report, we studied the effect of vitamin E on MSUM-mediated hemolysis in human erythrocytes. Vitamin E significantly inhibited hemolysis induced by MSUM. The hydroxyl group in the chromanol ring of vitamin E is dispensable for protecting erythrocytes against hemolysis induced by MSUM, indicating that the inhibitory effect of vitamin E is not due to its antioxidant properties. However, both the chromanol ring and the isoprenoid side chain are important for vitamin E to suppress MSUM-induced hemolysis. Our current study suggests that vitamin E inhibits hemolysis induced by MSUM as a membrane stabilizer.
Xie
Qiong
Q
Institute of Space Medico-Engineering, Beijing 100094, China.
Li
Shude
S
Feng
Weiyang
W
Li
Yongzhi
Y
Wu
Yuanliang
Y
Hu
Wei
W
Huang
Youguang
Y
D000975:Antioxidants / Q000494:pharmacology*; D003460:Crystallization; D004305:Dose-Response Relationship, Drug; D004910:Erythrocyte Membrane / Q000187:drug effects* / Q000378:metabolism; D006461:Hemolysis / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D007552:Isotonic Solutions / Q000737:chemistry; D007700:Kinetics; D014527:Uric Acid / Q000037:antagonists & inhibitors / Q000378:metabolism / Q000494:pharmacology*; D014810:Vitamin E / Q000494:pharmacology*
D000975:Antioxidants; D007552:Isotonic Solutions; D014810:Vitamin E; D014527:Uric Acid