title: Solitary extramedullary plasmacytoma of the canine larynx.
abstract: An 11-year-old, female, spayed cocker spaniel was presented with dysphonia caused by a solitary laryngeal mass. Excisional biopsy was performed, and a diagnosis of plasmacytoma was made on the basis of histological examination. Further investigations showed no signs of systemic involvement. Coarse fractionated radiation therapy failed to control the tumour. Therapy was successfully instituted with a conventional combination chemotherapy protocol over a period of 14 months. The dog remains disease free 30 months after diagnosis. Most solitary, extramedullary plasmacytomas in dogs arise in the gastrointestinal tract, with fewer reports in other sites. The larynx is an uncommon sight of involvement in any species, and to the authors' knowledge, this is the first report of this tumour type in the canine larynx. In contrast to the therapeutic benefits reported in humans, the combination of surgery and radiation therapy was unsuccessful in this case, although sustained remission was gained following chemotherapy.
authors.affiliation: Animal Health Trust, Lanwandes Park, Kentford, Newmarket, Suffolk CB8 7UU.
authors.forename: A M
authors.initials: AM
authors.lastname: Hayes
authors.forename: S P
authors.initials: SP
authors.lastname: Gregory
authors.forename: S
authors.initials: S
authors.lastname: Murphy
authors.forename: J F
authors.initials: JF
authors.lastname: McConnell
authors.forename: J C
authors.initials: JC
authors.lastname: Patterson-Kane
mesh_terms: D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D018572:Disease-Free Survival; D004283:Dog Diseases / Q000188:drug therapy* / Q000473:pathology; D004285:Dogs; D005260:Female; D007150:Immunohistochemistry / Q000662:veterinary; D007822:Laryngeal Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D010954:Plasmacytoma / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D013997:Time Factors; D016896:Treatment Outcome