Multipotent stem and progenitor cells of the olfactory epithelium.
In recent decades, a wide spectrum of fetal and embryonic stem and progenitor cells were used for cell therapy of diseases of the central nervous system, but the olfactory glial ensheathing cells exhibited certain advantages due to their biological properties and capacity to stimulate regeneratory processes in spinal injury. The therapeutic effect of a heterogeneous complex of olfactory epithelial cells is more pronounced; apart from glial ensheathing cells, this complex includes fibroblasts, Schwann cells, stem and progenitor cells of this structure. The use of minimally invasive methods for isolation of human olfactory epithelial tissue is important for clinical practice, because they provide cells for autologous transplantation and rule out graft rejection immune reaction and the risk of transmission viral infection and transfer of genetic defects, which can be associated with allotransplantation.
Viktorov
I V
IV
V. P. Serbsky State Research Center of Social and Forensic Psychiatry, Moscow. victorov_iv@bk.ru
Savchenko
E A
EA
Ukhova
O V
OV
Alekseyeva
N Yu
NY
Chekhonin
V P
VP
D000818:Animals; D006801:Humans; D039902:Multipotent Stem Cells / Q000166:cytology / Q000502:physiology*; D009830:Olfactory Bulb / Q000502:physiology; D009831:Olfactory Mucosa / Q000166:cytology / Q000502:physiology*; D009832:Olfactory Nerve / Q000502:physiology; D018034:Olfactory Receptor Neurons / Q000502:physiology; D013234:Stem Cells / Q000166:cytology / Q000502:physiology*