title: Synthesis and biological evaluation of diamine-based histamine H3 antagonists with serotonin reuptake inhibitor activity.
abstract: The synthesis and structure-activity relationships of a series of novel phenoxyphenyl diamine derivatives with affinity for both the histamine H(3) receptor and the serotonin transporter is described.
authors.affiliation: Johnson & Johnson Pharmaceutical Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA 92121, USA. estockin@prdus.jnj.com
authors.forename: Emily M
authors.initials: EM
authors.lastname: Stocking
authors.forename: Jennifer M
authors.initials: JM
authors.lastname: Miller
authors.forename: Ann J
authors.initials: AJ
authors.lastname: Barbier
authors.forename: Sandy J
authors.initials: SJ
authors.lastname: Wilson
authors.forename: Jamin D
authors.initials: JD
authors.lastname: Boggs
authors.forename: Heather M
authors.initials: HM
authors.lastname: McAllister
authors.forename: Jiejun
authors.initials: J
authors.lastname: Wu
authors.forename: Timothy W
authors.initials: TW
authors.lastname: Lovenberg
authors.forename: Nicholas I
authors.initials: NI
authors.lastname: Carruthers
authors.forename: Ronald L
authors.initials: RL
authors.lastname: Wolin
mesh_terms: D003959:Diamines / Q000737:chemistry*; D006633:Histamine Antagonists / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D015394:Molecular Structure; D018100:Receptors, Histamine H3 / Q000737:chemistry / Q000187:drug effects*; D017367:Selective Serotonin Reuptake Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D003959:Diamines; D006633:Histamine Antagonists; D018100:Receptors, Histamine H3; D017367:Selective Serotonin Reuptake Inhibitors