title: Inhibitory activities of three classes of acyclic nucleoside phosphonates against murine polyomavirus and primate simian virus 40 strains.
abstract: Murine polyomavirus and simian virus 40 were used to evaluate the potencies of the compounds of three classes of acyclic nucleoside phosphonates: (i) the original HPMP (3-hydroxy-2-phosphonomethoxypropyl) and PME (2-phosphonomethoxyethyl) derivatives, (ii) the 6-[2-(phosphonomethoxy)alkoxy]-2,4-diaminopyrimidine (DAPy) derivatives, and (iii) a new class of HPMP derivatives containing a 5-azacytosine moiety. The last class showed the highest activities and selectivities against both polyomaviruses.
authors.affiliation: Rega Institute for Medical Research, K.U. Leuven, Minderbroedersstraat 10, Leuven, Belgium.
authors.forename: Ilya
authors.initials: I
authors.lastname: Lebeau
authors.forename: Graciela
authors.initials: G
authors.lastname: Andrei
authors.forename: Marcela
authors.initials: M
authors.lastname: Krecmerová
authors.forename: Erik
authors.initials: E
authors.lastname: De Clercq
authors.forename: Antonin
authors.initials: A
authors.lastname: Holy
authors.forename: Robert
authors.initials: R
authors.lastname: Snoeck
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry / Q000145:classification / Q000494:pharmacology* / Q000633:toxicity; D002460:Cell Line; D000077404:Cidofovir; D003596:Cytosine / Q000031:analogs & derivatives / Q000494:pharmacology / Q000633:toxicity; D051379:Mice; D008826:Microbial Sensitivity Tests; D009705:Nucleosides / Q000737:chemistry / Q000145:classification / Q000494:pharmacology* / Q000633:toxicity; D063065:Organophosphonates / Q000737:chemistry / Q000145:classification / Q000494:pharmacology* / Q000633:toxicity; D011120:Polyomavirus / Q000187:drug effects*; D011741:Pyrimidine Nucleosides / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D011743:Pyrimidines / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D013539:Simian virus 40 / Q000187:drug effects*
chemical_list: D000998:Antiviral Agents; D009705:Nucleosides; D063065:Organophosphonates; D011741:Pyrimidine Nucleosides; D011743:Pyrimidines; C017205:2,4-diaminopyrimidine; D003596:Cytosine; D000077404:Cidofovir