Task-related differential dynamics of EEG alpha- and beta-band synchronization in cortico-basal motor structures.
Movement-related processing results in the modulation of neuronal synchronization over several electroencephalography (EEG) frequency ranges, including alpha- (8-12 Hz) and beta-band (14-30 Hz). Whether modulation patterns differ across sites within the motor system remains unclear, but could denote how information is conveyed across the cortico-basal network. We therefore compared the event-related synchronization/desynchronization (ERS/ERD) in recordings from the scalp, basal ganglia and thalamic structures during a motor task. Simultaneous depth and scalp EEG were recorded in 13 patients, undergoing deep brain stimulation of the thalamic ventral intermediate nucleus (VIM) or the subthalamic nucleus (STN). They performed a choice-reaction task with pre-cued Go-signals, instructive for either left- or right-sided button presses. In the beta-band, pre-cues and Go-signals were followed by ERD starting well before and peaking at task execution, uniformly in all cortical and subcortical recordings. In contrast, a comparable alpha-band ERD was only seen at the scalp, whereas mirror-like ERS were observed in the motor-inhibitory STN. In VIM, which receives strong somatosensory afferences, a major alpha-ERD upon the Go-signal did not start until the motor response. These dissociations of task-related Alpha- and Beta-band dynamics tag a functional diversity in cortico-basal networks, which are simultaneously active in motor processing. Whereas the uniform downregulation of Beta-activity points to an anti-kinetic operation mode throughout the motor system, site-dependent courses of Alpha-synchronization rather reflect the coordination of activity levels in functionally divergent motor structures during the preparation and execution of movements.
Klostermann
Fabian
F
Department of Neurology, CBF/CVK, Charité-University Medicine Berlin, Berlin, Germany. fabian.klostermann@charite.de
Nikulin
Vadim V
VV
Kühn
Andrea Annette
AA
Marzinzik
Frank
F
Wahl
Michael
M
Pogosyan
Alek
A
Kupsch
Andreas
A
Schneider
Gerd-Helge
GH
Brown
Peter
P
Curio
Gabriel
G
D000328:Adult; D000368:Aged; D000513:Alpha Rhythm; D001611:Beta Rhythm; D001931:Brain Mapping; D002755:Choice Behavior / Q000502:physiology*; D003344:Cortical Synchronization; D046690:Deep Brain Stimulation / Q000379:methods; D004569:Electroencephalography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009044:Motor Cortex / Q000503:physiopathology*; D009069:Movement Disorders / Q000503:physiopathology* / Q000601:surgery; D017711:Nonlinear Dynamics; D011597:Psychomotor Performance / Q000502:physiology / Q000528:radiation effects; D011930:Reaction Time / Q000502:physiology / Q000528:radiation effects