title: Clinical response and tolerability to and safety of saquinavir with low-dose ritonavir in human immunodeficiency virus type 1-infected mothers and their infants.
abstract: Saquinavir boosted with low-dose ritonavir given with zidovudine and lamivudine was well tolerated by pregnant women and their infants. All mothers had <400 human immunodeficiency virus type 1 RNA copies/ml at delivery. Two had elevated liver transaminases and amylase. Seven infant adverse events were possibly treatment related (anemia, neutropenia, and hyperbilirubinemia).
authors.affiliation: Obstetrics and Gynecology Department, UPR School of Medicine, P.O. Box 365067, San Juan, Puerto Rico. czorrilla@rcm.upr.edu
authors.forename: Carmen D
authors.initials: CD
authors.lastname: Zorrilla
authors.forename: Russell
authors.initials: R
authors.lastname: Van Dyke
authors.forename: Arlene
authors.initials: A
authors.lastname: Bardeguez
authors.forename: Edward P
authors.initials: EP
authors.lastname: Acosta
authors.forename: Betsy
authors.initials: B
authors.lastname: Smith
authors.forename: Michael D
authors.initials: MD
authors.lastname: Hughes
authors.forename: Sharon
authors.initials: S
authors.lastname: Huang
authors.forename: D Heather
authors.initials: DH
authors.lastname: Watts
authors.forename: Barbara
authors.initials: B
authors.lastname: Heckman
authors.forename: Eleanor
authors.initials: E
authors.lastname: Jiménez
authors.forename: George
authors.initials: G
authors.lastname: McSherry
authors.forename: Lynne
authors.initials: L
authors.lastname: Mofenson
mesh_terms: D019380:Anti-HIV Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000821:virology; D015497:HIV-1 / Q000187:drug effects; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control; D008826:Microbial Sensitivity Tests; D009035:Mothers; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy* / Q000821:virology; D012367:RNA, Viral / Q000097:blood; D018894:Reverse Transcriptase Inhibitors / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D019438:Ritonavir / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D019258:Saquinavir / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D019380:Anti-HIV Agents; D012367:RNA, Viral; D018894:Reverse Transcriptase Inhibitors; D019258:Saquinavir; D019438:Ritonavir