Epigenetics and microRNAs.
MicroRNAs (miRNAs) regulate protein-coding genes post transcriptionally in higher eukaryotes. Argonaute proteins are important in miRNA regulation and are also implicated in epigenetic mechanisms such as histone modifications and DNA methylation. Here, we review miRNA regulation and outline its connections to epigenetics.
Saetrom
Pål
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Division of Molecular Biology, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA.
Snøve
Ola
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Rossi
John J
JJ
D000818:Animals; D044127:Epigenesis, Genetic; D005786:Gene Expression Regulation; D006801:Humans; D035683:MicroRNAs / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D009690:Nucleic Acid Conformation; D016601:RNA-Binding Proteins / Q000235:genetics / Q000378:metabolism
D035683:MicroRNAs; D016601:RNA-Binding Proteins