title: Hybrid gadolinium oxide nanoparticles: multimodal contrast agents for in vivo imaging.
abstract: Luminescent hybrid nanoparticles with a paramagnetic Gd2O3 core were applied as contrast agents for both in vivo fluorescence and magnetic resonance imaging. These hybrid particles were obtained by encapsulating Gd2O3 cores within a polysiloxane shell which carries organic fluorophores and carboxylated PEG covalently tethered to the inorganic network. Longitudinal proton relaxivities of these particles are higher than the positive contrast agents like Gd-DOTA which are commonly used for clinical magnetic resonance imaging. Moreover these particles can be followed up by fluorescence imaging. This study revealed that these particles suited for dual modality imaging freely circulate in the blood vessels without undesirable accumulation in lungs and liver.
authors.affiliation: Laboratoire de Physico-Chimie des Matériaux Luminescents, UMR 5620 CNRS-Université Claude Bernard Lyon 1, 69622 Villeurbanne Cedex, France.
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Bridot
authors.forename: Anne-Charlotte
authors.initials: AC
authors.lastname: Faure
authors.forename: Sophie
authors.initials: S
authors.lastname: Laurent
authors.forename: Charlotte
authors.initials: C
authors.lastname: Rivière
authors.forename: Claire
authors.initials: C
authors.lastname: Billotey
authors.forename: Bassem
authors.initials: B
authors.lastname: Hiba
authors.forename: Marc
authors.initials: M
authors.lastname: Janier
authors.forename: Véronique
authors.initials: V
authors.lastname: Josserand
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Coll
authors.forename: Luce Vander
authors.initials: LV
authors.lastname: Elst
authors.forename: Robert
authors.initials: R
authors.lastname: Muller
authors.forename: Stéphane
authors.initials: S
authors.lastname: Roux
authors.forename: Pascal
authors.initials: P
authors.lastname: Perriat
authors.forename: Olivier
authors.initials: O
authors.lastname: Tillement
mesh_terms: D000818:Animals; D003287:Contrast Media / Q000737:chemistry / Q000493:pharmacokinetics*; D005453:Fluorescence; D005682:Gadolinium / Q000097:blood / Q000737:chemistry / Q000493:pharmacokinetics*; D006571:Heterocyclic Compounds / Q000737:chemistry; D008099:Liver / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D051379:Mice; D008819:Mice, Nude; D053758:Nanoparticles / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry; D051381:Rats; D012833:Siloxanes / Q000737:chemistry
chemical_list: D003287:Contrast Media; D006571:Heterocyclic Compounds; D009942:Organometallic Compounds; D012833:Siloxanes; D011092:Polyethylene Glycols; C030581:gadolinium oxide; C050823:gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate; D005682:Gadolinium