title: Post-infarction remodeling is independent of mitogen-activated protein kinase kinase 3 (MKK3).
abstract: OBJECTIVE
  Our aim was to examine the role of mitogen-activated protein kinase kinase 3 (MKK3) in the development of left ventricular (LV) remodeling following myocardial infarction (MI).
  
  
  METHODS
  MKK3-null mice were subjected to permanent coronary artery ligation. Twenty-eight days after MI, haemodynamics in male mkk3+/+(WT) and mkk3-/-(KO) littermates were assessed using a pressure-conductance catheter. MI groups were compared to un-operated time-matched WT and KO controls.
  
  
  RESULTS
  MI caused significant LV contractile dysfunction and dilatation which did not differ by genotype. Detailed morphometric analysis of excised hearts confirmed these similar global indices of remodeling and also demonstrated that pathological changes within remote myocardium and scar did not differ between KO and WT hearts.
  
  
  CONCLUSIONS
  Despite numerous lines of evidence suggesting MKK3 is the relevant kinase upstream of p38 mitogen-activated protein kinase in LV remodeling these processes can continue in its absence.
authors.affiliation: The Cardiovascular Division, Kings College London, The Rayne Institute, St Thomas' Hospital, London, UK.
authors.forename: James E
authors.initials: JE
authors.lastname: Clark
authors.forename: Richard A
authors.initials: RA
authors.lastname: Flavell
authors.forename: Matthew E
authors.initials: ME
authors.lastname: Faircloth
authors.forename: Roger J
authors.initials: RJ
authors.lastname: Davis
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Heads
authors.forename: Michael S
authors.initials: MS
authors.lastname: Marber
mesh_terms: D000818:Animals; D004108:Dilatation, Pathologic; D015151:Immunoblotting; D048371:MAP Kinase Kinase 3 / Q000235:genetics / Q000502:physiology*; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D009200:Myocardial Contraction; D009203:Myocardial Infarction / Q000201:enzymology*; D009206:Myocardium / Q000201:enzymology*; D016277:Ventricular Function, Left; D020257:Ventricular Remodeling / Q000502:physiology*
chemical_list: D048371:MAP Kinase Kinase 3