Neuroimmunomodulatory effect of antibodies against GABA on acute generalized and chronic epileptiform activity.
We studied the possibility of induction of anti-GABA autoantibodies during chronic epileptization of the brain and the effect of systemic intraperitoneal administration of anti-GABA antibodies to C57Bl/6 mice on acute generalized and chronic epileptiform activity. It was found for the first time that chronic epileptization is accompanied by induction of anti-GABA autoantibody synthesis. Antibodies against GABA produced a proepileptic effect.
Karpova
M N
MN
Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow. niiopp@mail.ru
Vetrile
L A
LA
Trekova
N A
NA
Kuznetsova
L V
LV
Klishina
N Yu
NY
Evseev
V A
VA
D000818:Animals; D001323:Autoantibodies / Q000096:biosynthesis*; D004827:Epilepsy / Q000209:etiology* / Q000276:immunology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D015213:Neuroimmunomodulation; D012640:Seizures / Q000139:chemically induced; D005680:gamma-Aminobutyric Acid / Q000276:immunology*
D001323:Autoantibodies; D005680:gamma-Aminobutyric Acid