title: Bacterial infection of fly ovaries reduces egg production and induces local hemocyte activation.
abstract: Morbidity, the state of being diseased, is an important aspect of pathogenesis that has gone relatively unstudied in fruit flies. Our interest is in characterizing how bacterial pathogenesis affects various physiologies of the fly. We chose to examine the fly ovary because we found bacterial infection had a striking effect on fly reproduction. We observed decreased egg laying after bacterial infection that correlated with increased bacterial virulence. We also found that bacteria colonized the ovary in a previously undescribed manner; bacteria were found in the posterior of the ovary, adjacent to the lateral oviduct. This local infection in the ovary resulted in melanization and activation of the cellular immune response at the site of infection.
authors.affiliation: Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.
authors.forename: Stephanie M
authors.initials: SM
authors.lastname: Brandt
authors.forename: David S
authors.initials: DS
authors.lastname: Schneider
mesh_terms: D000818:Animals; D004330:Drosophila / Q000276:immunology / Q000382:microbiology* / Q000502:physiology; D005260:Female; D006434:Hemocytes / Q000276:immunology*; D010053:Ovary / Q000276:immunology / Q000382:microbiology / Q000503:physiopathology; D010057:Oviducts / Q000276:immunology / Q000382:microbiology; D010058:Oviposition; D012098:Reproduction; D012486:Salmonella typhimurium / Q000254:growth & development / Q000276:immunology / Q000472:pathogenicity*