title: Brugada syndrome masquerading as febrile seizures.
abstract: Fever can precipitate ventricular tachycardia in adults with Brugada syndrome, but such a link has not been reported in children. A 21-month-old white girl presented repeatedly with decreased conscious level and seizures during fever. During a typical episode, rapid ventricular tachycardia was documented. The resting 12-lead electrocardiogram revealed a Brugada electrocardiogram signature. Resting electrocardiograms of the asymptomatic brother and mother were normal, but fever in the mother and pharmacologic stress with ajmaline in the brother revealed Brugada electrocardiogram features. Genetic testing revealed an SCN5A mutation in the affected family members.
authors.affiliation: Greenlane Paediatric and Congenital Cardiac Services, Starship Children's Hospital, Grafton, Auckland, New Zealand. jskinner@adhb.govt.nz
authors.forename: Jonathan Robert
authors.initials: JR
authors.lastname: Skinner
authors.forename: Seo-Kyung
authors.initials: SK
authors.lastname: Chung
authors.forename: Carey-Anne
authors.initials: CA
authors.lastname: Nel
authors.forename: Andrew Neil
authors.initials: AN
authors.lastname: Shelling
authors.forename: Jackie Robyn
authors.initials: JR
authors.lastname: Crawford
authors.forename: Neil
authors.initials: N
authors.lastname: McKenzie
authors.forename: Ralph
authors.initials: R
authors.lastname: Pinnock
authors.forename: John Kerswell
authors.initials: JK
authors.lastname: French
authors.forename: Mark Ian
authors.initials: MI
authors.lastname: Rees
mesh_terms: D053840:Brugada Syndrome / Q000175:diagnosis* / Q000235:genetics / Q000503:physiopathology; D003937:Diagnosis, Differential; D004562:Electrocardiography; D005260:Female; D006801:Humans; D007223:Infant; D009124:Muscle Proteins / Q000235:genetics; D009154:Mutation; D062554:NAV1.5 Voltage-Gated Sodium Channel; D003294:Seizures, Febrile / Q000175:diagnosis* / Q000235:genetics / Q000503:physiopathology; D015222:Sodium Channels / Q000235:genetics
chemical_list: D009124:Muscle Proteins; D062554:NAV1.5 Voltage-Gated Sodium Channel; C568320:SCN5A protein, human; D015222:Sodium Channels