title: [Using plaferon in patients with nephrolithiasis of the only kidney].
abstract: We have studied the influence of the Plaferon on the stimulation of restoration of a kidney function in patients with nephrolithiasis of the only kidney. The researches were performed in 42 patients with nephrolithiasis of the only kidney (control group-23; group accepted Plaferon-19 patients). In group of the patients, which accepted Plaferon, the creatinine clearance after two weeks from the operation was increased (58.1+/-5.9 ml/min) and achieve statistically main differs from those in control group (40.1+/-4.2 ml/min; p<0.05). There was detected correlation between "osmolar free" water reabsorption in each nephron and mass of the active nephrons. In control group these correlations are weak and couldn't be evaluated as positive one. In both groups we couldn't detect correlation between excretion fraction of filtered Natrium and reabsorption of "osmolar free" water. Plaferon positively influences process of stimulation of restoration of a renal function at post-operative period in patients with nephrolithiasis of the only kidney and to restoration of the urine passage. After using Plaferon at post-operative period we can detect the better function of the glomerular filtration and other investigated parameters, which differs from those in control group. Plaferon should be used in patients with nephrolithiasis of the only kidney for stimulation of restoration of a renal function at postoperative period.
authors.forename: V A
authors.initials: VA
authors.lastname: Sulkhanishvili
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009392:Nephrectomy; D053040:Nephrolithiasis / Q000188:drug therapy / Q000473:pathology / Q000601:surgery; D009479:Neuropeptides / Q000627:therapeutic use*; D011182:Postoperative Care
chemical_list: D009479:Neuropeptides; C091912:plaferon