Proteomics in uveal melanoma research: opportunities and challenges in biomarker discovery.
Uveal melanoma (UM) is the most frequent primary intraocular tumor in adult humans. Despite the significant advances in diagnosis and treatment of UM in the last decades, the prognosis of UM sufferers is still poor. Metastatic liver disease is the leading cause of death in UM and can develop after a long disease-free interval, suggesting the presence of occult micrometastasis. Proteomics technology has opened new opportunities for elucidating the molecular mechanism of complex diseases, such as cancer. This article will review the recent developments in biomarker discovery for UM research by proteomics. In the last few years, the first UM proteomics-based analyses have been launched, yielding promising results. An update on recent developments on this field is presented.
Pardo
María
M
Universidad de Santiago de Compostela, Laboratorio de Endocrinología Molecular, Departamento de Medicina, Complejo Hospitalario Universitario de Santiago, Santiago de Compostela, Spain. maruxapardo@hotmail.com.
Dwek
Raymond A
RA
Zitzmann
Nicole
N
D015415:Biomarkers; D035843:Biomedical Research; D006801:Humans; D008545:Melanoma; D009362:Neoplasm Metastasis; D009363:Neoplasm Proteins / Q000032:analysis*; D040901:Proteomics / Q000379:methods*; D014604:Uveal Neoplasms
D015415:Biomarkers; D009363:Neoplasm Proteins