title: Peripheral ulcerative keratitis-like findings associated with filgrastim.
abstract: OBJECTIVE
  To describe an ocular side effect occurring with filgrastim therapy.
  
  
  METHODS
  Retrospective case report.
  
  
  RESULTS
  One week after starting therapy with intravenous filgrastim, a 66-year-old woman developed bilateral keratitis, evidenced by epithelial defects and peripheral corneal infiltrates. When filgrastim was discontinued, symptoms improved within 3 days and resolved within 2 weeks.
  
  
  CONCLUSIONS
  Our patient's bilateral keratitis, which abated rapidly after discontinuation of filgrastim, may have been an adverse effect of this drug. Although the patient also took pamidronate, timing and resolution of symptoms make this a less likely culprit. Physicians should be aware of the possibility of filgrastim-associated keratitis, which can be managed by discontinuing the drug or treating with artificial tears.
authors.affiliation: Casey Eye Institute, Oregon Health and Science University, Portland, OR 97239-4197 , USA. eyedrug@ohsu.edu
authors.forename: Frederick W
authors.initials: FW
authors.lastname: Fraunfelder
authors.forename: Devin
authors.initials: D
authors.lastname: Harrison
mesh_terms: D000368:Aged; D003320:Corneal Ulcer / Q000139:chemically induced* / Q000175:diagnosis; D005260:Female; D000069585:Filgrastim; D016179:Granulocyte Colony-Stimulating Factor / Q000009:adverse effects*; D006801:Humans; D007262:Infusions, Intravenous; D011994:Recombinant Proteins; D012189:Retrospective Studies
chemical_list: D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor; D000069585:Filgrastim