[Fixed drug eruption : about 13 cases].
OBJECTIVE
To discuss, through a retrospective study, the epidemiological and clinical aspects and the causative agents of fixed drug eruption.


METHODS
Thirteen cases were collected retrospectively during 11 years. There were 10 females and 3 males with a mean age of 44 years.


RESULTS
The lesions correspond to erythematous plaques which fade to leave slate-brawn macules in all cases. The most frequent localizations were limbs (12 cases), trunk (6 cases), face (3 cases) ans external genitals (3 cases). Sulfonamides were the most frequent responsible drugs in our series (7 cases).


CONCLUSIONS
Fixed drug eruption is characterized by one or more erythematous plaques which recur in the same places after challenge. Sulfonamides are actually the most frequent causative drugs in the different series.
Daoud
Wafa
W
Service de Dermatologie, Hôpital Charles Nicolle, Tunis, Tunisie.
Zeglaoui
Faten
F
Kastalli
Sarra
S
Elfekih
Nadia
N
Fazaa
Bécima
B
Loueslati
Mohamed
M
Belkahia
Chalbi
C
Kamoun
Mohamed R
MR
D000082:Acetaminophen / Q000009:adverse effects*; D000328:Adult; D000368:Aged; D018712:Analgesics, Non-Narcotic / Q000009:adverse effects*; D014151:Anti-Anxiety Agents / Q000009:adverse effects*; D001960:Bromazepam / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D003875:Drug Eruptions / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D008620:Meprobamate / Q000009:adverse effects*; D008875:Middle Aged; D012189:Retrospective Studies; D013449:Sulfonamides / Q000009:adverse effects*
D018712:Analgesics, Non-Narcotic; D014151:Anti-Anxiety Agents; D013449:Sulfonamides; D000082:Acetaminophen; D008620:Meprobamate; D001960:Bromazepam