Effect of beta-blockers on bone mass and biomechanical parameters of the femoral neck in males with acute myocardial infarction.
OBJECTIVE
Evaluate the effect of cardioselective beta-blockers on bone mass and biomechanical properties of the femoral neck in males with acute myocardial infarction.


METHODS
Forty males with acute myocardial infarction were studied during one year. Seventy-five percent of the patients (30 patients) were treated with cardioselective beta-blockers and 10 were not similarly treated. A hip densitometry was performed upon release and one year later. The BMD was measured in the femoral neck and in biomechanical elements obtained by DXA.


RESULTS
Both groups had similar clinical conditions at the beginning of the study and after a one-year follow-up. No differences in the BMD (0.934+/-0.12 vs. 0.921+/-0.14) were observed in the group without beta-blockers or in the group with beta-blockers (0.980+/-0.12 vs. 0.977+/-0.12). No differences were observed in the measured structural parameters.


CONCLUSIONS
The cardioselective beta-blockers do not modify bone mass or the structural bone parameters in males with acute myocardial infarction.
Pérez-Castrillón
José L
JL
Departamento de Medicina Interna, Hospital Universitario Río Hortega, Facultad de Medicina de Valladolid, C/Torquemada s/n, Valladolid 47010, Spain. castrv@terra.es
Vega
Gemma
G
Abad
Laura
L
Sanz
Alberto
A
Mendo
Marcelino
M
Porrero
Miguel García
MG
Dueñas
Antonio
A
D015502:Absorptiometry, Photon; D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage*; D000368:Aged; D001696:Biomechanical Phenomena; D015519:Bone Density / Q000187:drug effects*; D005265:Femoral Neck Fractures / Q000517:prevention & control; D005272:Femur Neck / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000502:physiology; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy*
D000319:Adrenergic beta-Antagonists