title: Four cardiac hormones eliminate 4-fold more human glioblastoma cells than the green mamba snake peptide.
abstract: Within 24h four cardiac hormones, i.e., vessel dilator, kaliuretic peptide, atrial natriuretic peptide, and long acting natriuretic peptide decrease the number of human glioblastoma cells 75%, 68%, 67%, and 65% while Dendroaspis (green mamba) peptide caused a 17% decrease when each were utilized at 100 microM. The four cardiac hormones decreased DNA synthesis 65-87% and increased cyclic GMP 1.3- to 3.8-fold in the glioblastoma cells. Natriuretic peptide receptors (NPR)-A and -C were present.
  
  
  CONCLUSIONS
  four cardiac hormones eliminate up to 75% of glioblastoma cells via cyclic GMP-mediated up to 87% decrease in DNA synthesis.
authors.affiliation: Department of Internal Medicine, James A Haley Veterans Medical Center, Tampa, FL 33612, USA.
authors.forename: Brian A
authors.initials: BA
authors.lastname: Vesely
authors.forename: Ehrentraud J
authors.initials: EJ
authors.lastname: Eichelbaum
authors.forename: Abdel A
authors.initials: AA
authors.lastname: Alli
authors.forename: Ying
authors.initials: Y
authors.lastname: Sun
authors.forename: William R
authors.initials: WR
authors.lastname: Gower
authors.forename: David L
authors.initials: DL
authors.lastname: Vesely
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D015153:Blotting, Western; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D004273:DNA, Neoplasm / Q000096:biosynthesis; D004305:Dose-Response Relationship, Drug; D017815:Elapidae / Q000378:metabolism; D005909:Glioblastoma / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D006801:Humans; D009206:Myocardium / Q000737:chemistry / Q000378:metabolism; D010446:Peptide Fragments / Q000494:pharmacology; D010455:Peptides / Q000494:pharmacology*; D011498:Protein Precursors / Q000494:pharmacology*; D017461:Receptors, Atrial Natriuretic Factor / Q000378:metabolism; D013997:Time Factors
chemical_list: D000970:Antineoplastic Agents; D004273:DNA, Neoplasm; D010446:Peptide Fragments; D010455:Peptides; D011498:Protein Precursors; C075322:atrial natriuretic factor precursor (79-98); C054547:atrial natriuretic factor prohormone (1-30), human; C054548:atrial natriuretic factor prohormone (31-67); D009320:Atrial Natriuretic Factor; D017461:Receptors, Atrial Natriuretic Factor