Association of the 5-HT2A receptor gene polymorphism 102T/C with ischemic stroke.
Serotonin (5-HT) has been implicated in a number of cardiovascular disorders due to its ability to induce vascular contraction and platelet aggregation through activation of the 5-HT2 receptor family. In this study, we investigated the association of stroke in a Scandinavian population with two common polymorphisms in the 5-HT2A receptor gene. The two polymorphisms under investigation, namely the 102T/C and the -1438A/G variations of the 5-HT2A receptor gene, were examined in a case control association study involving 99 stroke patients and a comparable number of controls. Among patients, the prevalence of the homozygous 102T/T genotype was significantly higher than in controls (28.3% vs 13.5%; p < 0.01). The allelic frequency of 102T carriers was also significantly higher in stroke patients than in controls (p = 0.002, OR = 1.88, 95% CI, 1.27-2.80). The association between the 102T allele and stroke was significant in both males and females. There was no association between stroke and the -1438A/G polymorphism. Taken together, this study indicates that the 102T/C polymorphism in the 5-HT2A receptor gene could be an independent risk factor for developing stroke.
Olesen
Ole F
OF
Laboratory of Neuropsychiatry, Department of Psychiatry, Copenhagen University Hospital (Rigshospitalet), Copenhagen Ø, Denmark. ofo@curix.com
Bennike
Bente
B
Dam
Henrik
H
Mellerup
Erling
E
D002545:Brain Ischemia / Q000235:genetics*; D016009:Chi-Square Distribution; D003596:Cytosine; D004247:DNA / Q000097:blood / Q000235:genetics / Q000302:isolation & purification; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D020641:Polymorphism, Single Nucleotide; D044402:Receptor, Serotonin, 5-HT2A / Q000235:genetics*; D012016:Reference Values; D017384:Sequence Deletion; D013941:Thymine
D044402:Receptor, Serotonin, 5-HT2A; D003596:Cytosine; D004247:DNA; D013941:Thymine