title: Six-minute walk test in Chagas cardiomyopathy.
abstract: We studied systematically, for the first time, the utility of the six-minute walk test (6MWT) in Chagas disease. The walked distance at 6MWT correlated negatively with the increased circulating levels of monocyte chemoattractant protein (MCP-1, r=-0.358, p=0.04) and natriuretic peptide type B (BNP, r=-0.349, p=0.04), as well as positively with ejection fraction deterioration (r=0.451, p=0.004), indicating that submaximal functional capacity of chagasic patients is related to the severity of the cardiopathy. 6MWT may constitute an auxiliary tool in the evaluation of the clinical status of Chagas disease patients.
authors.forename: Lidiane
authors.initials: L
authors.lastname: Sousa
authors.forename: Fernando Antônio
authors.initials: FA
authors.lastname: Botoni
authors.forename: Raquel R
authors.initials: RR
authors.lastname: Britto
authors.forename: Manoel Otávio da Costa
authors.initials: MO
authors.lastname: Rocha
authors.forename: Antonio Lúcio
authors.initials: AL
authors.lastname: Teixeira
authors.forename: Mauro Martins
authors.initials: MM
authors.lastname: Teixeira
authors.forename: Adelina M
authors.initials: AM
authors.lastname: Reis
authors.forename: Bráulio Muzzi R
authors.initials: BM
authors.lastname: Oliveira
authors.forename: Antonio L
authors.initials: AL
authors.lastname: Ribeiro
mesh_terms: D002598:Chagas Cardiomyopathy / Q000097:blood* / Q000503:physiopathology*; D018932:Chemokine CCL2 / Q000097:blood*; D005080:Exercise Test; D017079:Exercise Tolerance; D005260:Female; D006801:Humans; D007249:Inflammation; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010865:Pilot Projects; D013318:Stroke Volume; D013997:Time Factors
chemical_list: D018932:Chemokine CCL2; D020097:Natriuretic Peptide, Brain