title: Glutathione and associated enzymes in toxic cataractogenesis-selenite model.
abstract: Glutathione, gamma-glutamyl cysteine synthetase (gamma -GCS) and glutathione reductase (GSH-R) activity were determined biochemically in the lens during various stages after subcutaneous administration of sodium selenite in multiple low dosages and single high dosages. The GSH concentration and gamma-GCS and GSH-R activity declined progressively after the selenite administration. The changes observed were discussed in relation to the possible role of selenite interaction with GSH and the enzymes.
authors.affiliation: Department of Zoology, St. Berchmans' College, Changanacherry - 686 101, India. jopmat@rediffmail.com
authors.forename: Joe Prasad
authors.initials: JP
authors.lastname: Mathew
authors.forename: Priya
authors.initials: P
authors.lastname: Joseph
authors.forename: V C
authors.initials: VC
authors.lastname: Thomas
authors.forename: Issac
authors.initials: I
authors.lastname: Thomas
mesh_terms: D000818:Animals; D002386:Cataract / Q000139:chemically induced / Q000201:enzymology* / Q000378:metabolism; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005260:Female; D005721:Glutamate-Cysteine Ligase / Q000378:metabolism*; D005978:Glutathione / Q000378:metabolism*; D005980:Glutathione Reductase / Q000378:metabolism; D007908:Lens, Crystalline / Q000201:enzymology / Q000378:metabolism; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D018038:Sodium Selenite / Q000633:toxicity*
chemical_list: D005980:Glutathione Reductase; D005721:Glutamate-Cysteine Ligase; D005978:Glutathione; D018038:Sodium Selenite