Antioxidant and neuroprotective properties of N-docosahexaenoyl dopamine.
N-Docosahexaenoyl dopamine exhibited antioxidant activity in the test with a stable oxygen radical galvinoxyl. This compound produced a dose-dependent protective effect on cultured granular cells from rat cerebellum under conditions of oxidative stress. N-Docosahexaenoyl dopamine decelerated the development of symptoms of Parkinson's disease in mice receiving neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
Bobrov
M Yu
MY
Laboratory of Oxylipins, M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences.
Lyzhin
A A
AA
Andrianova
E L
EL
Gretskaya
N M
NM
Zinchenko
G N
GN
Frumkina
L E
LE
Khaspekov
L G
LG
Bezuglov
V V
VV
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002478:Cells, Cultured; D002531:Cerebellum / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D004298:Dopamine / Q000031:analogs & derivatives* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D009474:Neurons / Q000187:drug effects / Q000502:physiology; D018696:Neuroprotective Agents / Q000494:pharmacology*; D018384:Oxidative Stress / Q000187:drug effects; D020734:Parkinsonian Disorders / Q000503:physiopathology; D051381:Rats
D000975:Antioxidants; C520236:N-docosahexaenoyl dopamine; D018696:Neuroprotective Agents; D004298:Dopamine