title: Evaluation of the risk of contamination of surgical personnel by vaporization of oxaliplatin during the intraoperative hyperthermic intraperitoneal chemotherapy (HIPEC).
abstract: OBJECTIVE
  To evaluate if oxaliplatin is likely to vaporize under HIPEC conditions and to see if it could be a source of pulmonary contamination for surgeons.
  
  
  METHODS
  Three oxaliplatin concentrations (230, 460 and 920 mg oxaliplatin/l), 3 heating temperatures (41, 43 and 45 degrees C) and 3 bubbling durations (30, 60 and 90 min) were tested. Drug vaporization was evaluated by using inductively coupled plasma mass spectrometry (ICP-MS) to analyze platinum concentrations in the trap solutions.
  
  
  RESULTS
  At all concentrations of oxaliplatin solutions, heating temperatures and bubbling trap periods, the quantities of vaporized platinum were always insignificantly lower than 1 microg/l.
  
  
  CONCLUSIONS
  The experimental risk of pulmonary contamination of hospital staff during HIPEC procedure appears to be negligible. However a monitoring study with an analysis of samples of the operating theatre and urine from surgical personnel should be carried out to confirm these conclusions.
authors.affiliation: Laboratory of Toxicology, ADEN EA 3234, Rouen University Faculty of Medicine and Pharmacy, 22 boulevard Gambetta, 76183, Rouen cedex, France. michel.guerbet@univ-rouen.fr
authors.forename: M
authors.initials: M
authors.lastname: Guerbet
authors.forename: J P
authors.initials: JP
authors.lastname: Goullé
authors.forename: J
authors.initials: J
authors.lastname: Lubrano
mesh_terms: D000970:Antineoplastic Agents / Q000633:toxicity; D003131:Combined Modality Therapy; D013502:General Surgery; D006801:Humans; D006979:Hyperthermia, Induced; D007263:Infusions, Parenteral; D016273:Occupational Exposure; D009873:Operating Rooms; D009944:Organoplatinum Compounds / Q000008:administration & dosage / Q000737:chemistry / Q000633:toxicity*; D000077150:Oxaliplatin; D018675:Toxicity Tests; D014835:Volatilization
chemical_list: D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; D000077150:Oxaliplatin