title: [Research study on renal targeted chemotherapy with magnetic harpoons and intravenous administration of ferro-carbon nanoparticles].
abstract: OBJECTIVE
  The use of nanoparticules for drug transport is one of the topics with priority interest within the field of biomedical research. Our objective is to show the initial results of an innovative method to focalize drug carrier ferro-carbon nanoparticules to solid organs. We obtained and characterized various types of ferrous magnetic nanoparticules and studied their behaviour in vitro and in vivo in laboratory animals with intrarenal magnetic targets laparoscopically implanted.
  
  
  METHODS
  Using a plasma arch we obtained ferro-carbon nanoparticules with the ability to absorb and deliver doxorubicin, showing an excellent behaviour in in vitro rheological studies. Under general anesthesia and control we inserted a gold covered magnetic microharpoon in the left kidney of New Zealand rabbits. At the same time we injected intravenously different doses of various types of nanoparticules. The animals were sacrified ofter pre-established times and pathologic studies of their kidneys, spleens, livers, lungs and bone marrow were carried out.
  
  
  RESULTS
  After selection of the most adequafe nanoparticules for our purposes, we ascertained significant differences in the distribution of nanoparticules in postmortem studies, with accumulation in the magnetic target and surrounding renal parenchyma. Nevertheless, the reticuloendothelial system retains a great amount of the injected dose.
  
  
  CONCLUSIONS
  Although our magnetic focalization system is effective, nanoparticule temporary protection systems should be tested to allow us avoid the action of the immune system.
authors.affiliation: Instituto Universitario de Investigación en Nanociencia de Aragón, Universidad de Zaragoza, Zaragoza. valdivia@unizar.es
authors.forename: José Gabriel
authors.initials: JG
authors.lastname: Valdivia Uríac
authors.forename: Manuel Ricardo
authors.initials: MR
authors.lastname: Ibarra García
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Fernández Pacheco
authors.forename: Américo
authors.initials: A
authors.lastname: Viloria
authors.forename: Teresa
authors.initials: T
authors.lastname: Higuera
authors.forename: Alicia
authors.initials: A
authors.lastname: Laborda
authors.forename: Angel
authors.initials: A
authors.lastname: García
authors.forename: José Antonio
authors.initials: JA
authors.lastname: García de Jalón
authors.forename: Martín
authors.initials: M
authors.lastname: Gutiérrez
authors.forename: Maria Soledad
authors.initials: MS
authors.lastname: Romero
authors.forename: Rosa
authors.initials: R
authors.lastname: Cornudella
authors.forename: Manuel
authors.initials: M
authors.lastname: Arruebo
authors.forename: Clara
authors.initials: C
authors.lastname: Marquina
authors.forename: Jordi
authors.initials: J
authors.lastname: Arbiol
authors.forename: Jesús
authors.initials: J
authors.lastname: Santamaría
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage*; D004317:Doxorubicin / Q000008:administration & dosage*; D004337:Drug Carriers; D006801:Humans; D007275:Injections, Intravenous; D007680:Kidney Neoplasms / Q000188:drug therapy*; D053758:Nanoparticles / Q000008:administration & dosage*; D011817:Rabbits
chemical_list: D000903:Antibiotics, Antineoplastic; D004337:Drug Carriers; D004317:Doxorubicin