[ssociation of HLA class I and II alleles with generalized vitiligo in Chinese Hans in north China].
OBJECTIVE
To investigate the association of HLA class I and II alleles with generalized vitiligo in ethnic Han Chinese in north China.


METHODS
By employing polymerase chain reaction sequence-specific primer (PCR-SSP) procedure 34 generalized vitiligo patients in north China were studied for HLA I and II alleles and were compared with 102 healthy controls.


RESULTS
The allelic frequencies of HLA-A*30, Cw*06, DRB1*07, and DQB1*0201 were increased significantly in generalized vitiligo and especially in the patients without family history compared with the controls.


CONCLUSIONS
These alleles positively associated with generalized vitiligo in Chinese Han patients in north China, might provide clues to reveal the susceptibility gene(s) of vitiligo in Chinese and as well as the immunnogenetic mechanisms of disease.
Wang
Jun
J
Department of Dermatology, No.1 Hospital of China Medical University, Shenyang, Liaoning, 110001 PR China.
Zhao
Yu-ming
YM
Wang
Yan
Y
Xiao
Yi
Y
Wang
Ya-kun
YK
Chen
Hong-duo
HD
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D044466:Asian People / Q000235:genetics; D002681:China; D005260:Female; D005787:Gene Frequency; D005805:Genes, MHC Class I / Q000235:genetics*; D005802:Genes, MHC Class II / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D014820:Vitiligo / Q000208:ethnology / Q000235:genetics*