Disordered lipid metabolism and the pathogenesis of insulin resistance.
Although abnormal glucose metabolism defines type 2 diabetes mellitus (T2DM) and accounts for many of its symptoms and complications, efforts to understand the pathogenesis of T2DM are increasingly focused on disordered lipid metabolism. Here we review recent human studies exploring the mechanistic links between disorders of fatty acid/lipid metabolism and insulin resistance. As "mouse models of insulin resistance" were comprehensively reviewed in Physiological Reviews by Nandi et al. in 2004, we will concentrate on human studies involving the use of isotopes and/or magnetic resonance spectroscopy, occasionally drawing on mouse models which provide additional mechanistic insight.
Savage
David B
DB
Department of Internal Medicine, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06536-8012, USA.
Petersen
Kitt Falk
KF
Shulman
Gerald I
GI
D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D005227:Fatty Acids / Q000494:pharmacology; D005947:Glucose / Q000378:metabolism; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D052439:Lipid Metabolism Disorders / Q000503:physiopathology*; D008099:Liver / Q000737:chemistry / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D009132:Muscles / Q000737:chemistry / Q000378:metabolism; D009765:Obesity / Q000378:metabolism
D005227:Fatty Acids; D005947:Glucose