Strand compositional asymmetries in vertebrate large genes.
Both transcription-associated and replication-associated strand compositional asymmetries have recently been shown in vertebrate genomes. In this paper, we illustrate that transcription-associated strand compositional asymmetries and replication-associated ones coexist in most vertebrate large genes, although in most case the former conceals the latter. Furthermore, we found that the transcription-associated strand compositional asymmetries of housekeeping genes are stronger than those of somatic cell expressed genes. Together with other evidence, we suggest that germline transcription-associated strand asymmetric mutations may be the main cause of the transcription-associated strand compositional asymmetries.
Wang
Hai-Fang
HF
Ministry of Education Key Laboratory for Biodiversity Science and Ecological Engineering, College of Life Sciences, Beijing Normal University, Beijing, 100875, China.
Hou
Wen-Ru
WR
Niu
Deng-Ke
DK
D000818:Animals; D001482:Base Composition / Q000235:genetics*; D004247:DNA / Q000235:genetics*; D004261:DNA Replication; D006801:Humans; D007438:Introns / Q000235:genetics; D009154:Mutation / Q000235:genetics; D012641:Selection, Genetic; D014158:Transcription, Genetic; D014714:Vertebrates / Q000235:genetics*
D004247:DNA