title: Melphalan in ultralow doses decreases the severity of experimental colitis in mice.
abstract: We studied the effect of melphalan in ultralow doses on mice with experimental colitis induced by substitution of drinking water for 5% dextran sulfate. Daily treatment with melphalan in a dose of 0.025 mg/kg improved the general state of animals. The influence of melphalan was evaluated by quantitative clinical, pathomorphological, and laboratory parameters. Melphalan had a local and systemic antiinflammatory effect.
authors.affiliation: Medical and Genetic Research Center, Russian Academy of Medical Sciences, Moscow. osugariver@ med_gen.ru
authors.forename: A L
authors.initials: AL
authors.lastname: Pukhalskii
authors.forename: G V
authors.initials: GV
authors.lastname: Shmarina
authors.forename: V A
authors.initials: VA
authors.lastname: Aleshkin
mesh_terms: D000818:Animals; D003092:Colitis / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D016264:Dextran Sulfate; D004305:Dose-Response Relationship, Drug; D007413:Intestinal Mucosa / Q000187:drug effects / Q000473:pathology; D007420:Intestine, Large / Q000187:drug effects / Q000473:pathology; D008297:Male; D008558:Melphalan / Q000627:therapeutic use*; D051379:Mice; D008807:Mice, Inbred BALB C
chemical_list: D016264:Dextran Sulfate; D008558:Melphalan