title: Effect of Kluyveromyces marxianus YIT 8292 crude cell wall fraction on serum lipids in normocholesterolemic and mildly hypercholesterolemic subjects.
abstract: The hypocholesterolemic effects of Kluyveromyces marxianus YIT 8292 crude cell wall (KM-CW) were examined. In pilot studies, KM-CW tablets were administered to mildly hypercholesterolemic subjects at doses of 8.0, 4.0, 2.0, or 1.0 g/d for 4 weeks. Total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) decreased at doses above 2.0 and 4.0 g/d, respectively. Further, we examined the effect of intake of yogurt containing 3.0 or 4.0 g of KM-CW/d for 8 weeks in normal and hypercholesterolemic subjects in a double-blind placebo-controlled study. The intake of either of the KM-CW-containing yogurts was associated with significantly improved TC and LDL-C in hypercholesterolemic subjects, but had no effect on these levels in normal subjects. TC was significantly lower at week 8 in the hypercholesterolemic subjects who ingested yogurt containing 3.0 or 4.0 g of KM-CW than in those who consumed placebo yogurt. Intake of KM-CW might contribute to the prevention of hypercholesterolemia.
authors.affiliation: Yakult Central Institute for Microbiological Research, Tokyo, Japan. yasuto-yoshida@yakult.co.jp
authors.forename: Yasuto
authors.initials: Y
authors.lastname: Yoshida
authors.forename: Eiichiro
authors.initials: E
authors.lastname: Naito
authors.forename: Kenji
authors.initials: K
authors.lastname: Ohishi
authors.forename: Takekazu
authors.initials: T
authors.lastname: Okumura
authors.forename: Masahiko
authors.initials: M
authors.lastname: Ito
authors.forename: Tadashi
authors.initials: T
authors.lastname: Sato
authors.forename: Haruji
authors.initials: H
authors.lastname: Sawada
mesh_terms: D000328:Adult; D000368:Aged; D002473:Cell Wall / Q000737:chemistry*; D002784:Cholesterol / Q000097:blood*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood*; D007716:Kluyveromyces / Q000737:chemistry*; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D013607:Tablets; D014280:Triglycerides / Q000097:blood; D015014:Yogurt
chemical_list: D008055:Lipids; D013607:Tablets; D014280:Triglycerides; D002784:Cholesterol