Vasculopathy and arterial stenotic lesions in the antiphospholipid syndrome.
The antiphospholipid (Hughes) syndrome (APS) is characterized by recurrent arterial or venous thromboembolism, or pregnancy loss, in association with antiphospholipid antibodies. These antibodies may be associated with premature or accelerated atherosclerosis and emerging evidence supports the concept of a vasculopathy in the APS that may lead to arterial stenotic lesions, possibly contributing to vascular occlusions and pregnancy morbidity.
Christodoulou
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The Lupus Research Unit, The Rayne Institute, St Thomas' Hospital, London, SE1 7EH, UK.
Sangle
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D'Cruz
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DP
D016736:Antiphospholipid Syndrome / Q000175:diagnosis*; D001157:Arterial Occlusive Diseases / Q000175:diagnosis*; D050197:Atherosclerosis / Q000175:diagnosis*; D003165:Complement System Proteins / Q000032:analysis; D005260:Female; D006801:Humans; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000175:diagnosis / Q000276:immunology
D003165:Complement System Proteins