Investigation of parent-of-origin effects in ADHD candidate genes.
Attention deficit hyperactivity disorder (ADHD) is a common early-onset childhood disorder with a strong genetic component. Results from previous studies have suggested that there may be a parent-of-origin effect for ADHD candidate genes. In particular, a recent investigation identified a pattern of paternal over-transmission of risk alleles for nine ADHD candidate genes. We examined this phenomenon in a sample of 291 trios for five genes previously associated with ADHD (HTR1B, SNAP-25, DRD5, DAT1, and BDNF). Using a dense map of markers and two analytic methods in this relatively large family-based sample, we do not find any evidence for significant paternal over-transmission of risk alleles in these candidate loci. Thus, we conclude that a substantial parent-of-origin effect is unlikely for these leading ADHD candidate genes.
Kim
Jang Woo
JW
Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA. jwkim@partners.org
Waldman
Irwin D
ID
Faraone
Stephen V
SV
Biederman
Joseph
J
Doyle
Alysa E
AE
Purcell
Shaun
S
Arbeitman
Lori
L
Fagerness
Jesen
J
Sklar
Pamela
P
Smoller
Jordan W
JW
D000483:Alleles; D001289:Attention Deficit Disorder with Hyperactivity / Q000235:genetics*; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics; D002648:Child; D050483:Dopamine Plasma Membrane Transport Proteins / Q000235:genetics; D005260:Female; D006801:Humans; D008297:Male; D010290:Parents; D020641:Polymorphism, Single Nucleotide; D044302:Receptor, Serotonin, 5-HT1B / Q000235:genetics; D050641:Receptors, Dopamine D5 / Q000235:genetics; D012307:Risk Factors; D050825:Synaptosomal-Associated Protein 25 / Q000235:genetics
D019208:Brain-Derived Neurotrophic Factor; C493605:DRD5 protein, human; D050483:Dopamine Plasma Membrane Transport Proteins; C470302:HTR1B protein, human; D044302:Receptor, Serotonin, 5-HT1B; C493214:SLC6A3 protein, human; C494208:SNAP25 protein, human; D050825:Synaptosomal-Associated Protein 25; D050641:Receptors, Dopamine D5