[Melatonin as a corrector of free radical oxidation processes during toxic damage of liver in rat].
Biochemiluminiscense parameters (light sum and maximum flash) show that free radical oxidation intensity (increased in serum blood of rats with toxic hepatitis) is decreased upon the treatment with melatonin. At the same time, the tg a2 value (reflecting the total antioxidant activity) changes toward the normal level, which indicated a decrease in the degree of antioxidant system mobilization. Superoxide dismutase and catalase activities (increased in the liver and blood serum of rats with toxic hepatitis) also showed the tendency to decrease upon the melatonin administration. Evidently, melatonin can act as a factor correcting the oxidative stress caused by the toxic damage of liver.
Popov
S S
SS
Pashkov
A N
AN
Popova
T N
TN
Semenikhina
A V
AV
Rakhmanova
T I
TI
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002374:Catalase / Q000037:antagonists & inhibitors; D056486:Chemical and Drug Induced Liver Injury / Q000201:enzymology / Q000378:metabolism*; D005609:Free Radicals / Q000037:antagonists & inhibitors; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D008550:Melatonin / Q000494:pharmacology*; D010084:Oxidation-Reduction / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D013482:Superoxide Dismutase / Q000037:antagonists & inhibitors
D000975:Antioxidants; D005609:Free Radicals; D002374:Catalase; D013482:Superoxide Dismutase; D008550:Melatonin