title: Fetal cerebral oxygenation: the role of maternal hyperoxia with supplemental CO2 in sheep.
abstract: OBJECTIVE
  We tested the hypothesis that supplemental CO2 can enhance the effect of maternal oxygen administration on fetal cerebral oxygenation.
  
  
  METHODS
  In near-term fetal sheep (n = 6), we instrumented the cerebral cortex with tissue PO2-laser Doppler flow probes, and placed arterial catheters. Following a 30-minute control period, the ewe breathed 50% O2 for 15 minutes, followed by added 6% CO2 for 15 minutes. We examined fetal cortical tissue PO2, cerebral blood flow (CBF), and fetal and maternal blood gases and related variables.
  
  
  RESULTS
  In response to maternal O2 administration, fetal arterial PO2, O2 content, cerebral O2 delivery, and cortical tissue PO2 increased significantly. In response to supplemental CO2 inhalation, fetal cortical tissue PO2 increased further. Fetal CBF also increased in response to the elevated arterial CO2 level.
  
  
  CONCLUSIONS
  CO2 supplementation of maternal O2 administration enhanced fetal cerebral oxygenation. In contrast, it was considered that during labor maternal hyperventilation with hypocapnia may blunt the effect of maternal O2 inhalation.
authors.affiliation: Center for Perinatal Biology and the Department of Physiology and Pharmacology, Loma Linda University School of Medicine, Loma Linda, CA 92350, USA.
authors.forename: Takuji
authors.initials: T
authors.lastname: Tomimatsu
authors.forename: Jorge Pereyra
authors.initials: JP
authors.lastname: Peña
authors.forename: Lawrence D
authors.initials: LD
authors.lastname: Longo
mesh_terms: D000818:Animals; D001784:Blood Gas Analysis; D002245:Carbon Dioxide / Q000378:metabolism / Q000494:pharmacology*; D002560:Cerebrovascular Circulation / Q000502:physiology; D004195:Disease Models, Animal; D005260:Female; D005311:Fetal Hypoxia / Q000517:prevention & control*; D018496:Hyperoxia; D008431:Maternal-Fetal Exchange; D010100:Oxygen / Q000008:administration & dosage*; D010101:Oxygen Consumption / Q000502:physiology*; D011247:Pregnancy; D011270:Pregnancy, Animal; D011336:Probability; D011897:Random Allocation; D012016:Reference Values; D012680:Sensitivity and Specificity; D034561:Sheep, Domestic
chemical_list: D002245:Carbon Dioxide; D010100:Oxygen