Gastroprotective properties of 11-deoxymisoprostol (prostaglandin E1 analog) and its effect on the level of sialic acids in gastric tissue of rats with peptic ulcer.
11-Deoxymisoprostol (prostaglandin E1 analog) exhibited a pronounced gastroprotective effect on various models of experimental ulcers induced by nonsteroid antiinflammatory drugs. A relationship between high resistance of the gastroduodenal mucosa under the effect of 11-deoxymisoprostol and changes in the level of sialic acid was detected.
Baschenko
N Zh
NZh
Department of Pharmacology No. 1, Bashkir State Medical University.
Sapozhnikova
T A
TA
Gabdrakhmanova
S F
SF
Makara
N S
NS
Khisamutdinova
R Yu
RY
Zarudii
F S
FS
Ivanova
N A
NA
Nazarov
V S
VS
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000633:toxicity; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D016595:Misoprostol / Q000031:analogs & derivatives* / Q000494:pharmacology; D010437:Peptic Ulcer / Q000139:chemically induced / Q000188:drug therapy / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D012794:Sialic Acids / Q000378:metabolism*
C475855:2-demethoxycarbonyl-2-ethoxycarbonyl-11-deoxymisoprostol; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000897:Anti-Ulcer Agents; D012794:Sialic Acids; D016595:Misoprostol