Dynamics of the protein spectrum changes in blood erythrocytes of male patients with prostate adenocarcinoma after plastic orchiectomy.
We have studied erythrocytes electrophoresis profiles in patients with prostate adenocarcinoma before and after plastic orchectomy and in healthy men to detect changes in the protein spectrum of erythrocytes. Our investigations have shown that during this pathology protein spectrum of erythrocytes structure undergoes substantial changes. This is demonstrated by losing of 35 KD molecular weight protein fraction and by appearance of 36 KD molecular weight protein fraction on the erythrocytes electrophoregram. It should be noted, that after plastic orchectomy we can see the relative normalization of erythrocyte's electrophoresis picture and it's approaching to the data of the control group (losing of 120 KD protein fraction and appearance of 48 KD protein fraction), which indicates to the normalization of the condition of the whole organism. It was detected that the synthesis of lower molecular protein fractions, on the one hand is influenced by rising of accantocytes percentage and on the other hand by the activation of the lipid oxidation process in erythrocytes membrane.
Veshapidze
N
N
Department of Exact and Natural Sciences, Iv. Javakhishvili Tbilisi State University, Georgia.
Alibegashvili
M
M
Chigogidze
T
T
Gabunia
N
N
Kotrikadze
N
N
D000230:Adenocarcinoma / Q000097:blood* / Q000601:surgery*; D000368:Aged; D001797:Blood Protein Electrophoresis / Q000379:methods; D004910:Erythrocyte Membrane / Q000378:metabolism; D004912:Erythrocytes / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009919:Orchiectomy / Q000379:methods*; D011184:Postoperative Period; D011471:Prostatic Neoplasms / Q000097:blood* / Q000601:surgery*; D019651:Plastic Surgery Procedures / Q000379:methods*