title: DepoDur extended-release epidural morphine: reshaping postoperative care. What perioperative nurses need to know.
abstract: Epidural morphine as a single bolus dose has demonstrated analgesia that lasts up to 24 hours. Recent advances in drug delivery mechanisms have resulted in a formulation of morphine, DepoDur, which is a lipid-encapsulated extended-release epidural morphine that provides up to 48 hours of analgesia. The efficacy of DepoDur has been established after hip arthroplasty, lower abdominal surgery involving an incision below the umbilicus, and elective cesarean section delivery. The unique characteristics of DepoDur dictate that clinicians must be aware of the benefits and risks, and facilities must have a comprehensive system to allow for the safe administration of DepoDur. This article provides information on this novel drug delivery system, reviews research findings reported in the literature, and describes the relational collaboration system designed and implemented at Duke University Health System for safe patient care of DepoDur recipients.
authors.affiliation: Duke University Medical Center, Durham, NC, USA.
authors.forename: Sherry
authors.initials: S
authors.lastname: Keck
authors.forename: Catherine
authors.initials: C
authors.lastname: Glennon
authors.forename: Brian
authors.initials: B
authors.lastname: Ginsberg
mesh_terms: D000701:Analgesics, Opioid / Q000008:administration & dosage* / Q000009:adverse effects; D000075202:Contraindications; D003692:Delayed-Action Preparations; D004496:Education, Continuing; D006801:Humans; D007268:Injections, Epidural; D009020:Morphine / Q000008:administration & dosage* / Q000009:adverse effects; D010149:Postoperative Pain / Q000188:drug therapy*; D016528:Postanesthesia Nursing
chemical_list: D000701:Analgesics, Opioid; D003692:Delayed-Action Preparations; D009020:Morphine