Activities of prolyl endopeptidase and dipeptidyl peptidase IV in brain structures of rats with dopamine deficiency-dependent MPTP-induced depressive syndrome.
The development of MPTP-induced depressive syndrome in rats was accompanied by activation of prolyl endopeptidase and dipeptidyl peptidase IV in the brain frontal cortex. Prolyl endopeptidase activity in the striatum also increased under these conditions. Our results indicate that proline-specific peptidases in the target structures of the brain dopaminergic system are involved in the pathogenesis of dopamine deficiency-dependent depressive states.
Krupina
N A
NA
Laboratory for General Pathophysiology of Nervous System, Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow. krupina-na@yandex.ru
Zolotov
N N
NN
Bogdanova
N G
NG
Orlova
I N
IN
Khlebnikova
N N
NN
Kryzhanovskii
G N
GN
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D000818:Animals; D001921:Brain / Q000201:enzymology*; D002540:Cerebral Cortex / Q000187:drug effects / Q000201:enzymology; D003866:Depressive Disorder / Q000139:chemically induced / Q000378:metabolism*; D018819:Dipeptidyl Peptidase 4 / Q000378:metabolism*; D004298:Dopamine / Q000172:deficiency*; D007031:Hypothalamus / Q000201:enzymology; D008297:Male; D000085822:Prolyl Oligopeptidases; D051381:Rats; D017208:Rats, Wistar; D012697:Serine Endopeptidases / Q000378:metabolism*
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D018819:Dipeptidyl Peptidase 4; D012697:Serine Endopeptidases; D000085822:Prolyl Oligopeptidases; D004298:Dopamine