title: Response to tetanus vaccination in infants exposed in utero to immunosuppressants for maternal autoimmune disorders.
abstract: Immunosuppressive drugs given during pregnancy to mothers suffering from a systemic autoimmune disease (AID) can cross the placenta, thus being potentially able to affect the offspring immune system. Aim of our study was to evaluate the in vivo immune function of a series of these newborns. Twenty-two babies born from mothers suffering from autoimmune diseases (AID) who had been taking immunosuppressive drugs during pregnancy were evaluated for their response to vaccination with C. Tetani toxoid. Six babies born from mothers receiving low-dose aspirin only were used as controls. The immune response to C. Tetani vaccination was evaluated with an ELISA to detect circulating antibodies. Five children out of 28 (17%) did not achieve a protective titer of anti C. Tetani toxoid IgG. No clear relationship was found between specific drug exposure and antibody response. Our findings suggest that maternal immunosuppressive treatment given for a systemic AID can affect the response to an active immunization, without specificities for drug types used.
authors.affiliation: Hospices Civils de Lyon- Universitè Lyon 1, Lyon, France. roland.cimaz@chu-lyon.fr
authors.forename: R
authors.initials: R
authors.lastname: Cimaz
authors.forename: E
authors.initials: E
authors.lastname: Meregalli
authors.forename: M
authors.initials: M
authors.lastname: Biggioggero
authors.forename: P
authors.initials: P
authors.lastname: Airò
authors.forename: E
authors.initials: E
authors.lastname: Danieli
authors.forename: C M
authors.initials: CM
authors.lastname: Antonioli
authors.forename: M
authors.initials: M
authors.lastname: Motta
authors.forename: G
authors.initials: G
authors.lastname: Chirico
authors.forename: D
authors.initials: D
authors.lastname: Columbrita
authors.forename: M
authors.initials: M
authors.lastname: Frassi
authors.forename: P L
authors.initials: PL
authors.lastname: Meroni
authors.forename: A
authors.initials: A
authors.lastname: Tincani
mesh_terms: D000328:Adult; D000906:Antibodies / Q000097:blood*; D001327:Autoimmune Diseases / Q000188:drug therapy*; D005260:Female; D005333:Fetus / Q000187:drug effects*; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology* / Q000627:therapeutic use; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy; D013745:Tetanus Toxoid / Q000276:immunology*
chemical_list: D000906:Antibodies; D007166:Immunosuppressive Agents; D013745:Tetanus Toxoid