title: Induction of human adiponectin gene transcription by telmisartan, angiotensin receptor blocker, independently on PPAR-gamma activation.
abstract: Adiponectin, an adipose tissue-specific plasma protein, has been shown to ameliorate insulin resistance and inhibit the process of atherosclerosis. Recently, several reports have stated that angiotensin type 1 receptor blockers (ARBs), increase adiponectin plasma level, and ameliorate insulin resistance. Telmisartan, a subclass of ARBs, has been shown to be a partial agonist of the peroxisome proliferator-activated receptor (PPAR)-gamma, and to increase the plasma adiponectin level. However, the transcriptional regulation of the human adiponectin gene by telmisartan has not been determined yet. To elucidate the effect of telmisartan on adiponectin, the stimulatory regulation of human adiponectin gene by telmisartan was investigated in 3T3-L1 adipocytes, utilizing adenovirus-mediated luciferase reporter gene-transferring technique. This study indicates that telmisartan may stimulate adiponectin transcription independent of PPAR-gamma.
authors.affiliation: Department of Endocrinology and Metabolism, Unit of Translational Medicine, Graduate School of Biomedical Science, Nagasaki University, and Hospital of Medicine and Dentistry, Nagasaki, Japan.
authors.forename: Akie
authors.initials: A
authors.lastname: Moriuchi
authors.forename: Hironori
authors.initials: H
authors.lastname: Yamasaki
authors.forename: Mika
authors.initials: M
authors.lastname: Shimamura
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kita
authors.forename: Hironaga
authors.initials: H
authors.lastname: Kuwahara
authors.forename: Keiichiro
authors.initials: K
authors.lastname: Fujishima
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Satoh
authors.forename: Keiko
authors.initials: K
authors.lastname: Fukushima
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Fukushima
authors.forename: Takao
authors.initials: T
authors.lastname: Hayakawa
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Mizuguchi
authors.forename: Yuji
authors.initials: Y
authors.lastname: Nagayama
authors.forename: Norio
authors.initials: N
authors.lastname: Abiru
authors.forename: Eiji
authors.initials: E
authors.lastname: Kawasaki
authors.forename: Katsumi
authors.initials: K
authors.lastname: Eguchi
mesh_terms: D041721:3T3-L1 Cells; D017667:Adipocytes / Q000187:drug effects / Q000378:metabolism*; D052242:Adiponectin / Q000235:genetics / Q000378:metabolism*; D047228:Angiotensin II Type 1 Receptor Blockers / Q000008:administration & dosage*; D000818:Animals; D001562:Benzimidazoles / Q000008:administration & dosage*; D001565:Benzoates / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D051379:Mice; D047495:PPAR gamma / Q000378:metabolism*; D000077333:Telmisartan; D015533:Transcriptional Activation / Q000187:drug effects / Q000502:physiology*
chemical_list: D052242:Adiponectin; D047228:Angiotensin II Type 1 Receptor Blockers; D001562:Benzimidazoles; D001565:Benzoates; D047495:PPAR gamma; D000077333:Telmisartan