title: In vitro study of dentinal tubule occlusion with sol-gel DP-bioglass for treatment of dentin hypersensitivity.
abstract: DP-bioglass paste has been demonstrated to produce 60 microm of sealing depth on exposed dentinal tubules. However, the occlusive effect depended on a continuous placement of DP-bioglass paste on dentinal surface for three days. In a bid to fabricate highly reactive DP-bioglass particles, a sol-gel method was used together with HNO3, NaOH, and H3PO4 as catalysts. As a result, the application time of DP-bioglass paste was significantly reduced to 10 minutes. Percentage of tubular occlusion with DP-bioglass was 53.2-65.4%, while One Coat Bond and Seal & Protect yielded 51.3% and 41.2% respectively. Further, the average depth of tubular occlusion with DP-bioglass was 55.8-62.7 microm, while One Coat Bond and Seal & Protect produced 40.8 microm and 32.5 microm respectively. In conclusion, the best sealing performance of tubular occlusion was rendered by DP-bioglass catalyzed with HNO3. Its performance was significantly better than Seal & Protect, and was considered to exhibit the greatest potential in treating dentin hypersensitivity.
authors.affiliation: Graduate Institute of Clinical Dentistry, College of Medicine, National Taiwan University, National Taiwan University Hospital, No. 1, Chang-Te Street, Taipei 10016, Taiwan.
authors.forename: Bor-Shiunn
authors.initials: BS
authors.lastname: Lee
authors.forename: Shu-Han
authors.initials: SH
authors.lastname: Kang
authors.forename: Yin-Lin
authors.initials: YL
authors.lastname: Wang
authors.forename: Feng-Huei
authors.initials: FH
authors.lastname: Lin
authors.forename: Chun-Pin
authors.initials: CP
authors.lastname: Lin
mesh_terms: D000293:Adolescent; D000328:Adult; D003738:Dental Cements / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D003804:Dentin / Q000648:ultrastructure; D003806:Dentin Permeability / Q000187:drug effects*; D003807:Dentin Sensitivity / Q000188:drug therapy*; D005782:Gels; D005898:Glass; D006801:Humans; D008689:Methacrylates / Q000494:pharmacology / Q000627:therapeutic use; D008855:Microscopy, Electron, Scanning; D008964:Molar, Third; D017942:Nitric Acid; D044367:Phase Transition; D019279:Resin Cements / Q000494:pharmacology / Q000627:therapeutic use; D013052:Spectrometry, X-Ray Emission; D013818:Thermogravimetry; D014961:X-Ray Diffraction
chemical_list: C418024:DP-bioactive glass paste; D003738:Dental Cements; D005782:Gels; D008689:Methacrylates; C426984:One Coat Bond; D019279:Resin Cements; C442646:Seal and Protect resin cement; C120461:sodium oxide-calcium oxide-silicon dioxide-diphosphorus pentoxide; D017942:Nitric Acid