Growth evaluation in infants with neonatal cholestasis.
BACKGROUND
[corrected] Chronic liver diseases in childhood often cause undernutrition and growth failure. To our knowledge, growth parameters in infants with neonatal cholestasis are not available


OBJECTIVE
To evaluate the nutritional status and growth pattern in infants with intrahepatic cholestasis and extrahepatic cholestasis.


METHODS
One hundred forty-four patients with neonatal cholestasis were followed up at the Pediatric Gastroenterology Service of the Teaching Hospital, State University of Campinas, Campinas, SP, Brazil, in a 23-year period, from 1980 to 2003. The records of these patients were reviewed and patients were classified into two groups, according to their anatomical diagnosis: patients with intrahepatic cholestasis - group 1, and patients with extrahepatic cholestasis - group 2. Records of weight and height measurements were collected at 4 age stages of growth, in the first year of life: 1) from the time of the first medical visit to the age of 4 months (T1); 2) from the 5th to the 7th month (T2); 3) from the 8th to the 10th month (T3); and 4) from the 11th to the 13th month (T4). The weight-by-age and height-by-age Z-scores were calculated for each patient at each stage. In order for the patient to be included in the study it was necessary to have the weight and/or height measurements at the 4 stages. Analyses of variance and Tukey's tests were used for statistical analysis. Repeated measurement analyses of variance of the weight-by-age Z-score were performed in a 60-patient sample, including 29 patients from group 1 and 31 patients from group 2. The height-by-age data of 33 patients were recorded, 15 from group 1 and 18 from group 2


RESULTS
The mean weight-by-age Z-scores of group 1 patients at the 4 age stages were: T1=-1.54; T2=-1.40; T3=-0.94; T4=-0.78. There was a significant difference between T2 X T3 and T1 X T4. The weight-by-age Z-scores for group 2 patients were :T1=-1.04; T2=-1.67; T3=-1.93 and T4=-1.77, with a significant difference between T1 X T2 and T1 X T4. The mean weight-by-age Z-scores also showed a significant difference between group 1 and group 2 at stages T3 and T4. The mean height-by-age Z-scores at the four stages in group 1 were: T1=-1.27; T2=-1.16; T3=-0.92 and T4=-0.22, with a significant difference between T3XT4 and T1XT4. The scores for group 2 patients were: T1=-0.93; T2=-1.89; T3=-2.26 and T4=-2.03, with a significant difference between T1XT2 and T1XT4. The mean height-by-age Z-scores also showed a significant difference between group 1 and group 2 at T3 and T4


CONCLUSIONS
The weight and height differences between the groups became significant from the 3rd measurement onward, with the most substantial deficit found in the extrahepatic group. In this group, there is evidence that the onset of weight and height deficit occurs between the first and second evaluation stages.
Prado
Camila Carbone
CC
Department of Pediatrics, State University of Campinas, SP, Brazil.
Nogueira
Roberto José Negrão
RJ
Barros-Filho
Antônio de Azevedo
Ade A
da Costa-Pinto
Elizete Aparecida Lomazi
EA
Hessel
Gabriel
G
D000704:Analysis of Variance; D000886:Anthropometry; D001827:Body Height / Q000502:physiology; D049628:Body Size / Q000502:physiology*; D001835:Body Weight / Q000502:physiology; D002657:Child Development / Q000502:physiology*; D001651:Cholestasis, Extrahepatic / Q000378:metabolism / Q000503:physiopathology*; D002780:Cholestasis, Intrahepatic / Q000378:metabolism / Q000503:physiopathology*; D006130:Growth Disorders / Q000378:metabolism / Q000503:physiopathology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007567:Jaundice, Neonatal / Q000503:physiopathology; D044342:Malnutrition / Q000378:metabolism / Q000503:physiopathology; D009752:Nutritional Status / Q000502:physiology*; D014280:Triglycerides / Q000493:pharmacokinetics
D014280:Triglycerides