title: Structure and properties of methacrylate-endcapped caprolactone networks with modulated water uptake for biomedical applications.
abstract: Methacrylate-endcapped caprolactone (CLMA) networks were synthesized and copolymerized with 2-hydroxyethyl acrylate (HEA) seeking to tailor the hydrophilicity of the system. The resulting structure of the copolymer network is investigated by differential scanning calorimetry, thermogravimetry, and Fourier transform infrared spectroscopy. The dynamic swelling behavior and the equilibrium water sorption is measured and correlated with the microstructure. The experimental results allow one to conclude that the new material is a random copolymer of both components, HEA and CLMA. The effect of cell attachment and proliferation on the new copolymer networks was observed by in vitro culture of human chondrocytes up to 8 days. Enhanced cellular adhesion, similar to that obtained with tissue culture polystyrene (TCPS), was obtained in the hydrophilized systems. The new copolymers are appropriate for the fabrication of scaffolds with controlled porosity for tissue engineering.
authors.affiliation: Center for Biomaterials, Universidad Politécnica de Valencia, 46022 Valencia, Spain.
authors.forename: J L Escobar
authors.initials: JL
authors.lastname: Ivirico
authors.forename: E Costa
authors.initials: EC
authors.lastname: Martínez
authors.forename: M Salmerón
authors.initials: MS
authors.lastname: Sánchez
authors.forename: I Muñoz
authors.initials: IM
authors.lastname: Criado
authors.forename: J L Gómez
authors.initials: JL
authors.lastname: Ribelles
authors.forename: M Monleón
authors.initials: MM
authors.lastname: Pradas
mesh_terms: D000179:Acrylates / Q000737:chemistry*; D001672:Biocompatible Materials / Q000737:chemistry*; D002208:Caproates / Q000737:chemistry*; D002448:Cell Adhesion; D049109:Cell Proliferation; D002478:Cells, Cultured; D019902:Chondrocytes / Q000166:cytology / Q000378:metabolism; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D007783:Lactones / Q000737:chemistry*; D008422:Materials Testing; D008689:Methacrylates / Q000737:chemistry*; D015394:Molecular Structure; D011108:Polymers / Q000737:chemistry*; D023822:Tissue Engineering / Q000295:instrumentation / Q000379:methods; D014867:Water / Q000737:chemistry*
chemical_list: D000179:Acrylates; D001672:Biocompatible Materials; D002208:Caproates; D007783:Lactones; D008689:Methacrylates; D011108:Polymers; D014867:Water; C035957:2-hydroxyethyl acrylate; C121056:caprolactone