title: [Adenosquamous and squamous carcinoma of the gallbladder].
abstract: BACKGROUND
  Squamous and adenosquamous carcinomas of the gallbladder have poor prognosis. Because these tumors are silent in the initial stage, they are generally diagnosed in advanced stages.
  
  
  METHODS
  We performed a retrospective observational study of five patients with squamous or adenosquamous carcinoma of the gallbladder. There were two women and three men with a mean age of 71 years (range, 68-75). All patients showed abdominal pain, nausea, vomiting, and weight lost (4-8 kg). One patient presented with acute cholecystitis. None of the patients had jaundice and all had gallstone disease.
  
  
  RESULTS
  Surgery was performed in all patients. Extended cholecystectomy was performed in three patients, cholecystectomy and bile drainage in one patient, and colonic bypass and cholecystectomy in the remaining patient. Pathologic analysis revealed epidermoid carcinoma in two patients and adenosquamous carcinoma in three patients. Two patients were treated with adjuvant chemotherapy. All died within 6 months of surgery.
  
  
  CONCLUSIONS
  In both histological types of gallbladder carcinoma, treatment depends on the grade of local and regional invasion and tumor spread at diagnosis.
authors.affiliation: Hospital Nacional de Clínicas, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba, Argentina.
authors.forename: Paul Eduardo
authors.initials: PE
authors.lastname: Lada
authors.forename: Bruno
authors.initials: B
authors.lastname: Taborda
authors.forename: Martín
authors.initials: M
authors.lastname: Sánchez
authors.forename: Juan
authors.initials: J
authors.lastname: Tommasino
authors.forename: Fernando Franco
authors.initials: FF
authors.lastname: Rosso
authors.forename: Luis
authors.initials: L
authors.lastname: Gramática
authors.forename: Jesús
authors.initials: J
authors.lastname: Alecha Gil
authors.forename: Miguel
authors.initials: M
authors.lastname: Echenique Elizondo
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology* / Q000601:surgery; D018256:Adenomatous Polyps / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000601:surgery; D005260:Female; D005706:Gallbladder Neoplasms / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008297:Male; D012189:Retrospective Studies; D014463:Ultrasonography