What is the best adjuvant treatment for very young patients with medulloblastoma?
The standard treatment for medulloblastoma is surgery followed by adjuvant chemotherapy and external beam radiotherapy to the craniospinal axis and posterior fossa. However, in very young children, craniospinal irradiation has a more significant detrimental effect in terms of neurocognitive function and growth. This article reviews the different strategies used for very young patients with medulloblastoma.
Clarke
James W
JW
Ohio State University Medical Center, Department of Radiation Medicine, Arthur G James Cancer Hospital, Columbus, OH 43210, USA. james.clarke@osumc.edu
Hadziahmetovic
Mersiha
M
Tzou
Katherine
K
Lau
Ching C
CC
Paulino
Arnold C
AC
Grecula
John C
JC
Montebello
Joseph F
JF
Mayr
Nina A
NA
Lo
Simon S
SS
D001932:Brain Neoplasms / Q000628:therapy*; D017024:Chemotherapy, Adjuvant / Q000379:methods*; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008527:Medulloblastoma / Q000628:therapy*; D018714:Radiotherapy, Adjuvant / Q000379:methods*