title: Experimental use of N-butyl cyanoacrylate tissue adhesive on lung parenchyma after pulmonary resection.
abstract: BACKGROUND
  The aim of this study was to investigate the effectiveness of N-butyl cyanoacrylate tissue adhesive for the prevention of air leak together with the morphological changes to lung parenchyma.
  
  
  METHODS
  Twelve New Zealand rabbits were used. The rabbits were ventilated with pressure-controlled ventilation during the experiment, beginning with a pressure level of 10 cm H (2)O. After a 2 x 2-cm pulmonary wedge resection, the resection surface was sealed with N-butyl cyanoacrylate and the pressure level was increased every five minutes in 5-cm H (2)O increments. The pressure level which caused an air leak from the resection surface was recorded. The morphological damage to the lung parenchyma was evaluated under light microscopy.
  
  
  RESULTS
  The mean value of the pressure levels that caused air leak was 43.3 +/- 8.8 cm H (2)O. No tissue damage to lung parenchyma was recorded after histopathological examination.
  
  
  CONCLUSIONS
  N-butyl cyanoacrylate was effective in preventing air leak from the pulmonary resection surface even with high airway pressure levels. It could be used as an aid for pulmonary resection lines or to control the air leak from pulmonary parenchyma.
authors.affiliation: Thoracic Surgery, Ege University, Izmir, Turkey.
authors.forename: U
authors.initials: U
authors.lastname: Cagirici
authors.forename: Y
authors.initials: Y
authors.lastname: Cetin
authors.forename: A
authors.initials: A
authors.lastname: Cakan
authors.forename: O
authors.initials: O
authors.lastname: Samancilar
authors.forename: A
authors.initials: A
authors.lastname: Veral
authors.forename: F Z
authors.initials: FZ
authors.lastname: Askar
mesh_terms: D000399:Air Pressure; D000818:Animals; D004659:Enbucrilate; D008297:Male; D011013:Pneumonectomy; D011030:Pneumothorax / Q000517:prevention & control*; D011817:Rabbits; D013536:Suture Techniques; D014014:Tissue Adhesives
chemical_list: D014014:Tissue Adhesives; D004659:Enbucrilate