Matrix metalloproteinases in peripheral vascular disease.
Matrix metalloproteinases (MMPs) are extracellular matrix-modifying enzymes that are important in many physiologic and pathologic vascular processes. Dysregulation of MMP activity has been associated with common vascular diseases such as atherosclerotic plaque formation, abdominal aortic aneurysms, and critical limb ischemia. For this reason, MMPs have become an important focus for basic science studies and clinical investigations by vascular biology researchers. This article reviews the recent literature, summarizing our current understanding of the role of MMPs in the pathogenesis of various peripheral vascular disease states. In addition, the importance of MMPs in the future diagnosis and treatment of peripheral vascular disease is discussed.
Hobeika
Mark J
MJ
Department of Surgery, New York University School of Medicine, New York, NY, USA.
Thompson
Robert W
RW
Muhs
Bart E
BE
Brooks
Peter C
PC
Gagne
Paul J
PJ
D000818:Animals; D017544:Aortic Aneurysm, Abdominal / Q000188:drug therapy / Q000201:enzymology; D050197:Atherosclerosis / Q000188:drug therapy / Q000201:enzymology; D015415:Biomarkers / Q000378:metabolism; D003251:Constriction, Pathologic / Q000188:drug therapy / Q000201:enzymology / Q000601:surgery; D004791:Enzyme Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D005121:Extremities / Q000098:blood supply; D006801:Humans; D007511:Ischemia / Q000188:drug therapy / Q000201:enzymology; D053505:Matrix Metalloproteinases, Secreted / Q000037:antagonists & inhibitors / Q000378:metabolism*; D016491:Peripheral Vascular Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000201:enzymology*; D012008:Recurrence; D019714:Tissue Inhibitor of Metalloproteinases / Q000378:metabolism; D014647:Varicose Ulcer / Q000188:drug therapy / Q000201:enzymology; D014648:Varicose Veins / Q000188:drug therapy / Q000201:enzymology; D014656:Vascular Surgical Procedures / Q000009:adverse effects; D020246:Venous Thrombosis / Q000188:drug therapy / Q000201:enzymology
D015415:Biomarkers; D004791:Enzyme Inhibitors; D019714:Tissue Inhibitor of Metalloproteinases; D053505:Matrix Metalloproteinases, Secreted