title: Predictive factors for corneal infiltrates with continuous wear of silicone hydrogel contact lenses.
abstract: OBJECTIVE
  To estimate the cumulative probability and risk factors for developing corneal infiltrates after up to 3 years of continuous wear (CW) with lotrafilcon A lenses.
  
  
  METHODS
  Patients were fitted with lotrafilcon A lenses and followed up for 3 years. The main outcome variable was the first occurrence of any infiltrative event in either eye. Cox proportional hazards regression was used to model the probability of developing infiltrates as a function of demographic and biomicroscopy findings.
  
  
  RESULTS
  A total of 317 patients participated in this study. The Kaplan-Meier unadjusted cumulative incidence of a corneal infiltrate after CW was 5.7% (95% confidence interval [CI], 3.0%-8.4%) at the end of 1 year, 8.5% (95% CI, 5.2%-11.9%) at the end of 2 years, and 10.3% (95% CI, 6.6%-13.9%) at the end of 3 years. Corneal staining and limbal redness present in the affected eye on a previous visit were significantly associated with the development of an infiltrative event (hazard ratios, 7.23 and 3.18; P<.001 and P = .02, respectively).
  
  
  CONCLUSIONS
  Corneal staining and limbal redness may predict the subsequent development of an infiltrative event among CW contact lens patients. The probability of remaining free of any corneal infiltrates at the end of 3 years of CW of contact lenses was 89.7% (95% CI, 86.1%-93.4%).
authors.affiliation: Department of Ophthalmology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA. loretta.szczotka@uhhs.com
authors.forename: Loretta
authors.initials: L
authors.lastname: Szczotka-Flynn
authors.forename: Sara M
authors.initials: SM
authors.lastname: Debanne
authors.forename: Vinay K
authors.initials: VK
authors.lastname: Cheruvu
authors.forename: Bill
authors.initials: B
authors.lastname: Long
authors.forename: Sally
authors.initials: S
authors.lastname: Dillehay
authors.forename: Joseph
authors.initials: J
authors.lastname: Barr
authors.forename: Peter
authors.initials: P
authors.lastname: Bergenske
authors.forename: Peter
authors.initials: P
authors.lastname: Donshik
authors.forename: Glenda
authors.initials: G
authors.lastname: Secor
authors.forename: John
authors.initials: J
authors.lastname: Yoakum
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D003262:Contact Lenses, Extended-Wear / Q000009:adverse effects*; D003315:Cornea / Q000473:pathology*; D003316:Corneal Diseases / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D020100:Hydrogels; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011336:Probability; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012307:Risk Factors; D012828:Silicones; D005466:Fluorocarbons
chemical_list: D020100:Hydrogels; D012828:Silicones; C481129:lotrafilcon A; D005466:Fluorocarbons