title: A novel monolayer cell line derived from human umbilical cord blood cells shows high sensitivity to measles virus.
abstract: Measles virus (MeV) research is largely dependent on the B95a cell line, which is derived from marmoset B lymphocytes. As this cell line is persistently infected with Epstein-Barr virus (EBV), a novel cell line, COBL-a, was established from human umbilical cord blood. COBL-a cells have a significant advantage over B95a cells because they are of human origin, are free from EBV and have higher sensitivity to wild-type MeV. Thus, COBL-a cells should prove very valuable for both epidemiological and basic studies of MeV.
authors.affiliation: NPO-Biomedical Science Association, Tokyo 169-0075, Japan.|Laboratory Animal Research Center, Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan.
authors.forename: Fumio
authors.initials: F
authors.lastname: Kobune
authors.affiliation: National Institute of Infectious Diseases (NIID), Tokyo 190-0011, Japan.
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Ami
authors.affiliation: NPO-Biomedical Science Association, Tokyo 169-0075, Japan.
authors.forename: Miki
authors.initials: M
authors.lastname: Katayama
authors.affiliation: National Institute of Infectious Diseases (NIID), Tokyo 190-0011, Japan.
authors.forename: Motohide
authors.initials: M
authors.lastname: Takahashi
authors.affiliation: National Center for Communicable Diseases, Ulaanbaatar 48, Mongolia.
authors.forename: Renchin
authors.initials: R
authors.lastname: Tuul
authors.affiliation: National Measles Laboratory, Virology Department, Refik Saydam National Hygiene Center, Ankara 18-06100, Turkey.
authors.forename: Gulay
authors.initials: G
authors.lastname: Korukluoglu
authors.affiliation: National Institute of Infectious Diseases (NIID), Tokyo 190-0011, Japan.
authors.forename: Tomoko
authors.initials: T
authors.lastname: Kiyohara
authors.affiliation: Laboratory Animal Research Center, Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan.
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Miura
authors.affiliation: Laboratory Animal Research Center, Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Sato
authors.affiliation: Laboratory Animal Research Center, Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan.
authors.forename: Misako
authors.initials: M
authors.lastname: Yoneda
authors.affiliation: Laboratory Animal Research Center, Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan.
authors.forename: Chieko
authors.initials: C
authors.lastname: Kai
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000821:virology; D001773:Blood Cells / Q000821:virology*; D002144:Callithrix; D002460:Cell Line; D005312:Fetal Blood / Q000166:cytology*; D006801:Humans; D007231:Infant, Newborn; D008459:Measles virus / Q000302:isolation & purification / Q000472:pathogenicity / Q000502:physiology*