Future aspects of bioprocess monitoring.
Nature has the impressive ability to efficiently and precisely control biological processes by applying highly evolved principles and using minimal space and relatively simple building blocks. The challenge is to transfer these principles into technically applicable and precise analytical systems that can be used for many applications. This article summarizes some of the new approaches in sensor technology and control strategies for different bioprocesses such as fermentations, biotransformations, and downstream processes. It focuses on bio- and chemosensors, optical sensors, DNA and protein chip technology, software sensors, and modern aspects of data evaluation for improved process monitoring and control.
Becker
Thomas
T
Universität Hohenheim, Process Analysis, Garbenstrasse 25, 70599 Stuttgart, Germany.
Hitzmann
Bernd
B
Muffler
K
K
Pörtner
Ralf
R
Reardon
Kenneth F
KF
Stahl
Frank
F
Ulber
Roland
R
D015374:Biosensing Techniques / Q000295:instrumentation / Q000379:methods*; D001709:Biotechnology / Q000295:instrumentation / Q000379:methods* / Q000639:trends; D017022:Flow Injection Analysis / Q000295:instrumentation / Q000379:methods; D020411:Oligonucleotide Array Sequence Analysis / Q000295:instrumentation / Q000379:methods; D040081:Protein Array Analysis / Q000295:instrumentation / Q000379:methods; D013050:Spectrometry, Fluorescence / Q000295:instrumentation / Q000379:methods; D019265:Spectroscopy, Near-Infrared / Q000295:instrumentation / Q000379:methods; D013059:Spectrum Analysis, Raman / Q000295:instrumentation / Q000379:methods