[Ulcerative colitis and thrombocytopenia: a clinical case of fortuitous association?].
Ulcerative colitis (UC) is an inflammatory bowel disease of unknown etiology, involving primarily the rectum with major intestinal symptoms. Additionally, UC is often associated with extraintestinal manifestations, especially arthropathies, as well as with some autoimmune disorders. Vice versa, UC is rarely described in association with hematologic abnormalities, such as autoimmune hemolytic anemia and immune thrombocytopenic purpura with antiplatelet antibodies positive. Usually UC precedes the onset of thrombocytopenia by days or years or coincides with it. We report a case of UC and thrombocytopenia with negative anti-platelet antibodies in which an immunosuppressive therapy with corticosteroids obtained significant remission of intestinal symptoms along with a rapid increase of platelet count.
Braucci
S
S
Dipartimento di Medicina Interna, Ospedale Sant'Andrea, II Facoltui di Medicina, Università di Roma La Sapienza, Roma, Italia.
Trappolini
F
F
Angrisani
L
L
Luberti
E
E
Clarice
A
A
Proietta
M
M
Pisani
D
D
Trappolini
M
M
D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000627:therapeutic use; D001706:Biopsy; D001803:Blood Transfusion; D003093:Colitis, Ulcerative / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology; D003106:Colon / Q000473:pathology; D003113:Colonoscopy; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D008297:Male; D019804:Mesalamine / Q000008:administration & dosage / Q000627:therapeutic use; D008775:Methylprednisolone / Q000008:administration & dosage / Q000627:therapeutic use; D008875:Middle Aged; D010976:Platelet Count; D013921:Thrombocytopenia / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D013997:Time Factors; D016896:Treatment Outcome
D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D005938:Glucocorticoids; D019804:Mesalamine; D008775:Methylprednisolone