Mitochondrial dysfunction: impact on exercise performance and cellular aging.
Innovative noninvasive methods open a new window on the cell in vivo. This window reveals that the tempo of mitochondrial dysfunction with age varies among muscles and in proportion to Type II muscle fiber content. Exercise training can reverse age-related dysfunction, thereby providing an intervention to slow the pace of aging and disability in the elderly.
Conley
Kevin E
KE
Department of Radiology, University of Washington Medical Center, Seattle, WA 98195-7115, USA. kconley@u.washington.edu
Jubrias
Sharon A
SA
Amara
Catherine E
CE
Marcinek
David J
DJ
D000328:Adult; D016922:Cellular Senescence / Q000502:physiology*; D004272:DNA, Mitochondrial; D015444:Exercise / Q000502:physiology*; D006801:Humans; D008931:Mitochondria, Muscle / Q000473:pathology / Q000502:physiology*; D018482:Muscle, Skeletal / Q000473:pathology / Q000502:physiology*; D013178:Sports Medicine
D004272:DNA, Mitochondrial