GSTT1 and GSTM1 null genotypes may facilitate hepatitis C virus infection becoming chronic.
Oxidative stress contributes to hepatitis C virus (HCV)-induced liver damage. The activity of antioxidant glutathione S-transferases (GSTs) T1 and M1 is polymorphic. The GSTT1 and GSTM1 genotypes were identified in 139 HCV-infected patients and in 329 healthy individuals. Among patients, there was an excess of GSTT1 (odds ratio [OR], 2.76 [95% confidence interval [CI], 1.77-4.30]; P<.001) and GSTM1 (OR, 1.54 [95% CI, 1.02-2.35]; P=.032) null genotypes and of double-null haplotypes (OR, 3.65 [95% CI, 1.98-6.75]; P<.001). The GSTT1 null genotype, particularly if associated with the GSTM1 null genotype, may facilitate HCV infection becoming chronic.
Martínez
Carmen
C
Department of Pharmacology and Psychiatry, University of Extremadura, Badajoz, Spain.
García-Martín
Elena
E
Ladero
José M
JM
Herráez
Oscar
O
Ortega
Luis
L
Taxonera
Carlos
C
Suárez
Avelina
A
Díaz-Rubio
Manuel
M
Agúndez
José A G
JA
D000328:Adult; D016022:Case-Control Studies; D015331:Cohort Studies; D018450:Disease Progression; D005260:Female; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics*; D016174:Hepacivirus / Q000201:enzymology* / Q000235:genetics*; D019698:Hepatitis C, Chronic / Q000473:pathology / Q000821:virology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013030:Spain; D044465:White People / Q000235:genetics
D005982:Glutathione Transferase; C413545:glutathione S-transferase T1