Hypoglycemic effect of Tournefortia hirsutissima L., on n-streptozotocin diabetic rats.
The hypoglycemic effect of aqueous and butanolic extracts from Tournefortia hirsutissima (Boraginaceae) was determined on neonatal induced streptozotocin diabetic rats (n-STZ). Oral administration of water extracts at doses of 20 and 80mg/kg, and butanolic extracts (8 and 80mg/kg) significantly lowered the plasma glucose levels in diabetic rats within 3h. Glibenclamide was used as reference and showed similar hypoglycemic effect. Our results support the traditional use of the plant as a hypoglycemic agent; we observe a dose-dependent action of the extracts. HPLC analysis confirmed that the aqueous and butanolic extracts had the same chemical composition.
Andrade-Cetto
Adolfo
A
Laboratorio de Etnofarmacología, Fac. Ciencias, Universidad Nacional Autónoma de México, 04510 México DF, Mexico. aac@hp.fciencias.unam.mx
Revilla-Monsalve
Cristina
C
Wiedenfeld
Helmut
H
D000284:Administration, Oral; D000818:Animals; D000831:Animals, Newborn; D001786:Blood Glucose / Q000187:drug effects*; D028082:Boraginaceae; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005905:Glyburide / Q000627:therapeutic use; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D008297:Male; D008519:Medicine, Traditional; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use; D018547:Plant Stems; D051381:Rats; D017208:Rats, Wistar
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D005905:Glyburide