[Study on the vertical transmission of Y chromosome microdeletions from father to son].
OBJECTIVE
To analyze the Y chromosome microdeletions in the family of the infertile male and to study on the vertical transmission of Y chromosome microdeletions from father to son.


METHODS
The peripheral blood of infertile patients' family male members was extracted and analyzed with modified multiplex PCR. The infertile family tree was drawn according to the results.


RESULTS
Two cases in twelve investigated families had azoospermia factor (AZFc) microdeletion heredity. The others had no heredity.


CONCLUSIONS
AZFc microdeletion of the Y chromosome can be transmitted to the male offspring naturally,and the same deletion can result in different phenotypes in different individuals.
Zhu
Xiao-bin
XB
Renji Hospital, Shanghai Jiaotong University, Shanghai, 200001 PR China.
Li
Zhen
Z
Guo
An-liang
AL
Cao
Xiao-rong
XR
Liu
Yong
Y
Gong
Dong-ming
DM
Wang
Yi-xin
YX
D000328:Adult; D000368:Aged; D053713:Azoospermia / Q000235:genetics*; D002872:Chromosome Deletion; D041322:Chromosomes, Human, Y / Q000235:genetics*; D005192:Family Health; D005260:Female; D006801:Humans; D007248:Infertility, Male / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D055815:Young Adult