title: Korean ginseng induces spermatogenesis in rats through the activation of cAMP-responsive element modulator (CREM).
abstract: The effect of Korean ginseng (ginseng) on spermatogenesis and cAMP-responsive element modulator (CREM) in rat testes was evaluated using sperm analysis, reverse transcription polymerase chain reaction, and Western blot analysis. The ginseng-treated rats exhibited significantly increased sperm count and motility with enhanced levels of CREM messenger RNA and protein. Ginseng appears to induce spermatogenesis via CREM activation in rat testes.
authors.affiliation: Department of Pathology, College of Oriental Medicine, Kyungwon University, Seongnam, Korea.
authors.forename: Wan Su
authors.initials: WS
authors.lastname: Park
authors.forename: Dong Youp
authors.initials: DY
authors.lastname: Shin
authors.forename: Do Rim
authors.initials: DR
authors.lastname: Kim
authors.forename: Woong Mo
authors.initials: WM
authors.lastname: Yang
authors.forename: Mun Seog
authors.initials: MS
authors.lastname: Chang
authors.forename: Seong Kyu
authors.initials: SK
authors.lastname: Park
mesh_terms: D000818:Animals; D051786:Cyclic AMP Response Element Modulator / Q000378:metabolism*; D008297:Male; D005894:Panax; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013076:Sperm Count; D013081:Sperm Motility / Q000187:drug effects; D013091:Spermatogenesis / Q000187:drug effects*
chemical_list: C497412:Crem protein, rat; D010936:Plant Extracts; D051786:Cyclic AMP Response Element Modulator