Repeated measurements of learned irrelevance by a novel within-subject paradigm in humans.
Learned irrelevance (LIrr) refers to the retardation of classical conditioning following preexposure of the to-be-associated stimuli. Healthy volunteers have been tested on three occasions with a new LIrr paradigm avoiding methodological problems which afflict traditional paradigms. A significant LIrr effect was demonstrated on each occasion. Thus, the new paradigm enables repeated measurements of LIrr and might be useful in evaluating long-term effects of medication in psychiatric disorders exhibiting aberrant LIrr.
Orosz
Ariane
A
Laboratory of Behavioral Biology, ETH Zürich, Switzerland.ariane.orosz@insel.ch
Feldon
Joram
J
Gal
Gilad
G
Simon
Andor
A
Cattapan-Ludewig
Katja
K
D000328:Adult; D001245:Association Learning; D001288:Attention; D035841:Behavioral Research / Q000379:methods*; D003214:Conditioning, Classical; D023381:Endpoint Determination; D005260:Female; D005364:Field Dependence-Independence; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000188:drug therapy; D010364:Pattern Recognition, Visual; D012016:Reference Values; D015203:Reproducibility of Results