Constituents of Oxandra cf. xylopioides with anti-inflammatory activity.
A new triterpenoid (1) derived from 24-methylcycloartanol was isolated from the leaves of Oxandra cf. xylopioides. An unusual structure of the new compound was assigned as 1, for which the name berenjenol is proposed, on the basis of the spectroscopic data of the natural product and of its derivatives 2 and 3. The leaves also afforded the known monoterpene isoespintanol (4). Compounds 1 and 4 significantly reduced the paw edema induced by carrageenan by 64% and 43%, at 3 h, respectively. Moreover, 4 reduced IL-1 beta production by 72% at 100 microM and reduced IL-1 beta mRNA synthesis.
Rojano
Benjamin
B
Laboratorio Ciencia de los Alimentos, Escuela de Química, Universidad Nacional de Colombia, Sede Medellín, A.A 3840, Medellín, Colombia.
Pérez
Edwin
E
Figadère
Bruno
B
Martin
Marie Thérèse
MT
Recio
María C
MC
Giner
Rosa
R
Ríos
José L
JL
Schinella
Guillermo
G
Sáez
Jairo
J
D000818:Animals; D029061:Annonaceae / Q000737:chemistry*; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002351:Carrageenan / Q000494:pharmacology; D003105:Colombia; D004487:Edema / Q000139:chemically induced*; D053583:Interleukin-1beta / Q000096:biosynthesis* / Q000187:drug effects; D051379:Mice; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
D000893:Anti-Inflammatory Agents; D053583:Interleukin-1beta; D014315:Triterpenes; C521026:berenjenol; D002351:Carrageenan