Erosive arthropathy: clinical variance in lupus erythematosus and association with anti-CCP case series and review of the literature.
OBJECTIVE
To describe the occurrence of erosive arthropathy in systemic lupus erythematosus (SLE) and its relationship to anti-CCP antibodies.


METHODS
Retrospective medical record review of a case series of five female patients with SLE and erosive arthropathies.


RESULTS
The initial disease presentation in all patients was a polyarthritis. Anti-CCP antibodies were detected in 4 out of 5 (80%) patients, 2 of whom had a positive rheumatoid factor.


CONCLUSIONS
Erosive arthritis was strongly associated with the presence of anti-CCP antibodies in these patients with SLE, who presented with polyarthritis. Anti-CCP in patients with SLE may be a marker of a more severe joint disease.
Martinez
J B
JB
Internal Medicine and Rheumatology, National University of Colombia, Bogota, Colombia.
Valero
J S
JS
Bautista
A J
AJ
Restrepo
J F
JF
Matteson
E L
EL
Rondon
F
F
Iglesias-Gamarra
A
A
D000328:Adult; D001172:Arthritis, Rheumatoid / Q000150:complications* / Q000276:immunology; D005260:Female; D050823:Hand Joints / Q000473:pathology*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000276:immunology; D008875:Middle Aged; D010456:Peptides, Cyclic / Q000276:immunology*; D010996:Pleural Effusion / Q000209:etiology; D012217:Rheumatoid Factor / Q000097:blood
D010456:Peptides, Cyclic; C487763:cyclic citrullinated peptide; D012217:Rheumatoid Factor