[Association of aldosterone synthase gene -344 T/C polymorphism with early renal damage in Han nationality with essential hypertension].
OBJECTIVE
To investigate whether the -344T/C polymorphism of aldosterone synthase gene is associated with early renal damage in Han nationality with essential hypertension in Shandong province.


METHODS
Plasma aldosterone concentration and urinary albumin excretion were measured with radioimmunoassays in 225 patients with essential hypertension, and hypertensives were classified as hypertension with normal albuminuria or hypertension with microalbuminuria according to urinary albumin excretion during 24 hours. -344T/C polymorphism of aldosterone synthase gene was determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in controls and hypertensives.


RESULTS
No significant differences were found in genotype distribution among groups of control, primary hypertension with normal albuminuria and hypertension with microalbuminuria. The C allele frequency in hypertension with microal buminuria group was significantly higher than that in control and hypertension with normal albuminuria group (P < 0.05). In hypertensive patients, plasma aldosterone concentration and urinary albumin excretion of TC+CC genotypes were significantly higher than that of TT genotype ( P< 0.05).


CONCLUSIONS
These results suggest that -344T/C polymorphism of aldosterone synthase gene may be associated with early renal damage in Han nationality with essential hypertension, C allele may be a genetic factor susceptible to renal damage in hypertensives.
Sun
Xiao-jian
XJ
Department of Cardiology, Affiliated Yuhuangding Hospital, Qingdao University, Yantai, Shandong, 264000 PR China. sunxj315@163.com
Liu
Shao-rong
SR
Zhang
Chuan-huan
CH
Yuan
Guo-hui
GH
Chen
Hong-ying
HY
Hou
Xiao-fei
XF
D000328:Adult; D000418:Albumins / Q000378:metabolism; D000419:Albuminuria / Q000097:blood / Q000235:genetics; D000450:Aldosterone / Q000097:blood; D044466:Asian People / Q000235:genetics; D002681:China; D019405:Cytochrome P-450 CYP11B2 / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000150:complications*; D007674:Kidney Diseases / Q000150:complications / Q000208:ethnology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011863:Radioimmunoassay
D000418:Albumins; D000450:Aldosterone; D019405:Cytochrome P-450 CYP11B2