Relationship between N,N-dialkyl chitosan monolayer and corresponding vesicle.
The properties of N,N-dialkyl chitosan monolayers and corresponding vesicles have been studied by LB technique and drug-release experiment. With increasing molecular weight of chitosan backbone and/or length of alkyl chain, both the compressibility and collapse pressure of N,N-dialkyl chitosan monolayer are enhanced. The experiments on drug-release behavior of N,N-dialkyl chitosan vesicles show that the drug-release rate and the equilibrium drug-release ratio are decreased with increasing the compressibility of corresponding monolayer. It is worth noticing that there is a linear relationship between the compressibility of N,N-dialkyl chitosan monolayers and the equilibrium drug-release ratio of the vesicles.
Li
Mingchun
M
College of Materials Science and Engineering, Huaqiao University, Quanzhou, Fujian 362021, PR China. mcli@hqu.edu.cn
Su
Sheng
S
Xin
Meihua
M
Liao
Yaozu
Y