The enantioselective Morita-Baylis-Hillman reaction and its aza counterpart.
The development of asymmetric Morita-Baylis-Hillman (MBH) reactions has evolved dramatically over the past few years, parallel to the emerging concept of bifunctional organocatalysis. Whereas organocatalysis is starting to compete with metal-based catalysis in several important organic transformations, the MBH reaction belongs to a group of prototypical reactions in which organocatalysts already display superiority over their metal-based counterparts. This Minireview summarizes recent mechanistic insights and advances in the design and synthesis of small organic molecules for enantioselective MBH and aza-MBH reactions.
Masson
Géraldine
G
Institut de Chimie des Substances Naturelles, CNRS, 91198 Gif-sur-Yvette Cedex, France. Geraldine.Masson@icsn.cnrs-gif.fr
Housseman
Christopher
C
Zhu
Jieping
J
D000588:Amines / Q000737:chemistry; D001372:Aza Compounds / Q000737:chemistry*; D002384:Catalysis; D002625:Chemistry, Organic; D008968:Molecular Conformation; D015394:Molecular Structure; D055601:Organic Chemistry Phenomena; D013237:Stereoisomerism
D000588:Amines; D001372:Aza Compounds