title: Nearly identical strains of human herpesvirus 8 in couples discordant for Kaposi's sarcoma.
abstract: Transmission of human herpesvirus 8 (HHV-8) may occur through various routes including breastfeeding and sexual intercourse. We attempted to detect HHV-8 infection in nine HIV-positive couples discordant for Kaposi's sarcoma who maintained a monogamous sexual relationship for at least one year. By quantitative real-time polymerase chain reaction and HHV-8 genotyping we provide strong evidence for the sexual transmission of HHV-8 in this unique cohort.
authors.affiliation: Instituto de Medicina Tropical Pedro Kouri, Ciudad de La Habana, Cuba.
authors.forename: Vivian
authors.initials: V
authors.lastname: Kouri
authors.forename: Alessandra
authors.initials: A
authors.lastname: Marini
authors.forename: Sandeep
authors.initials: S
authors.lastname: Nambiar
authors.forename: Maria E
authors.initials: ME
authors.lastname: Rodriguez
authors.forename: Virginia
authors.initials: V
authors.lastname: Capo
authors.forename: Sonia
authors.initials: S
authors.lastname: Resik
authors.forename: Beatriz
authors.initials: B
authors.lastname: Mantecon
authors.forename: Ariel
authors.initials: A
authors.lastname: Martinez
authors.forename: Karin J
authors.initials: KJ
authors.lastname: Köhler-Hansner
authors.forename: Ulrich R
authors.initials: UR
authors.lastname: Hengge
mesh_terms: D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D015331:Cohort Studies; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D005838:Genotype; D006679:HIV Seropositivity / Q000150:complications / Q000188:drug therapy / Q000821:virology*; D019288:Herpesvirus 8, Human / Q000302:isolation & purification*; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000821:virology; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction / Q000379:methods; D012514:Sarcoma, Kaposi / Q000150:complications / Q000821:virology*; D017386:Sequence Homology, Amino Acid; D012725:Sexual Behavior
chemical_list: D004279:DNA, Viral