title: Central physeal arrests as a manifestation of hypervitaminosis A.
abstract: Vitamin A is necessary for synthesis of visual pigments and required in appropriate amounts for membrane stability. Acute hypervitamin A intoxication can lead to increased intracranial pressure, vomiting, and lethargy. Chronic excessive intake of vitamin A can lead to pruritus, muscle and bone tenderness, and failure to thrive. Reported effects of hypervitamin A intoxication on bone include osteoporosis, fracture, cortical thickening, and metaphyseal irregularity. We are reporting on a case of central physeal arrest in the distal femur, proximal tibia, and distal tibia after excessive intake of vitamin A.
authors.affiliation: Department of Orthopaedic Surgery, Northwestern University.
authors.forename: Matthew D
authors.initials: MD
authors.lastname: Saltzman
authors.forename: Erik C
authors.initials: EC
authors.lastname: King
mesh_terms: D002675:Child, Preschool; D004838:Epiphyses / Q000000981:diagnostic imaging / Q000187:drug effects*; D005269:Femur / Q000000981:diagnostic imaging / Q000187:drug effects*; D006801:Humans; D006986:Hypervitaminosis A / Q000150:complications* / Q000000981:diagnostic imaging; D008297:Male; D011859:Radiography; D013977:Tibia / Q000000981:diagnostic imaging / Q000187:drug effects*