Improved biochemical strategies for targeted delivery of taxoids.
Paclitaxel (Taxol) and docetaxel (Taxotere) are very important anti-tumor drugs in clinical use for cancer. However, their clinical utility is limited due to systemic toxicity, low solubility and inactivity against drug resistant tumors. To improve chemotherapeutic levels of these drugs, it would be highly desirable to design strategies which bypass the above limitations. In this respect various prodrug and drug targeting strategies have been envisioned either to improve oral bioavailability or tumor specific delivery of taxoids. Abnormal properties of cancer cells with respect to normal cells have guided in designing of these protocols. This review article records the designed biochemical strategies and their biological efficacies as potential taxoid chemotherapeutics.
Ganesh
Thota
T
Department of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, GA 30322, USA. tganesh@emory.edu
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D000077143:Docetaxel; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D017239:Paclitaxel / Q000008:administration & dosage*; D011355:Prodrugs / Q000008:administration & dosage*; D043823:Taxoids / Q000008:administration & dosage*
D000970:Antineoplastic Agents; D011355:Prodrugs; D043823:Taxoids; D000077143:Docetaxel; D017239:Paclitaxel