Effect of endotoxemia on skin antioxidant enzymes under experimental conditions.
Intraperitoneal injection of bacterial lipopolysaccharide in a dose of 1 mg/kg was followed by prestimulation of whole blood leukocytes in rats. Activities of peroxide- and lipoperoxide-utilizing antioxidant enzymes glutathione peroxidase, glutathione S-transferase, and catalase increased 1 day after lipopolysaccharide administration, while the content of malonic dialdehyde in the skin remained unchanged.
Ivanova
A V
AV
Russian State Medical University; Russian People's Friendship University, Moscow.
Mikhal'chik
E V
EV
Miroshnikova
E A
EA
Lukasheva
E V
EV
Korkina
L G
LG
D000818:Animals; D002374:Catalase / Q000378:metabolism*; D019446:Endotoxemia / Q000139:chemically induced / Q000201:enzymology*; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism*; D005982:Glutathione Transferase / Q000378:metabolism*; D008070:Lipopolysaccharides / Q000633:toxicity; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012867:Skin / Q000201:enzymology*; D013482:Superoxide Dismutase / Q000378:metabolism
D008070:Lipopolysaccharides; D008315:Malondialdehyde; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005982:Glutathione Transferase; D005978:Glutathione