Prognostic value of human chorionic gonadotropin changes after methotrexate injection for ectopic pregnancy.
Because early prediction of clinical outcome (one or more injections or surgery) of methotrexate treatment of ectopic pregnancy could ease the intensity of follow-up and patient compliance required, we studied the relationship between the change in hCG levels after methotrexate injection and outcome in 129 consecutive patients. A 20% decline in hCG levels between days 1 and 4 during methotrexate treatment has a positive predictive value of 97%.
Agostini
Aubert
A
Service de Gynécologie Obstétrique, Hôpital La Conception, Marseille, France. aagostini@mail.ap-hm.fr <aagostini@mail.ap-hm.fr>
Blanc
Karina
K
Ronda
Isabelle
I
Romain
Fanny
F
Capelle
Mariane
M
Blanc
Bernard
B
D000020:Abortifacient Agents, Nonsteroidal / Q000008:administration & dosage; D006063:Chorionic Gonadotropin / Q000097:blood*; D005260:Female; D006801:Humans; D007267:Injections; D008727:Methotrexate / Q000008:administration & dosage*; D011237:Predictive Value of Tests; D011247:Pregnancy; D011258:Pregnancy Tests; D011271:Pregnancy, Ectopic / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy*; D011379:Prognosis; D012680:Sensitivity and Specificity
D000020:Abortifacient Agents, Nonsteroidal; D006063:Chorionic Gonadotropin; D008727:Methotrexate