Current concepts in the pathogenesis of nonalcoholic fatty liver disease.
Nonalcoholic fatty liver disease (NAFLD) is an increasingly recognized cause of chronic liver disease, representing the leading cause of hepatology referral in some centres. However, its pathophysiology is not completely understood. Insulin resistance is one of the major mechanisms involved in disease prevalence and progression. Owing to the lack of an effective pharmacological therapy, recommendations on treatment are scarce and are based mainly on lifestyle changes, including diet and exercise. A review of the current literature on pathogenesis of NAFLD is presented in this article.
Méndez-Sánchez
Nahum
N
Department of Biomedical Research, Gastroenterology & Liver Unit, Medica Sur Clinic & Foundation, Mexico City, Mexico. nmendez@medicasur.org.mx
Arrese
Marco
M
Zamora-Valdés
Daniel
D
Uribe
Misael
M
D005227:Fatty Acids / Q000378:metabolism; D005234:Fatty Liver / Q000209:etiology*; D006801:Humans; D007333:Insulin Resistance; D008099:Liver / Q000378:metabolism / Q000473:pathology; D053858:Metabolic Networks and Pathways
D005227:Fatty Acids