Human cytomegalovirus-associated oral and maxillo-facial disease.
Human cytomegalovirus is a ubiquitous pathogen with protean clinical manifestations. After initial infection, the virus remains in a persistent state in the host. Immunity plays a pivotal role in counteracting its virulence, albeit intermittent virus shedding occurs in immunocompetent individuals. Should deficiencies in immunity occur, e.g., as a consequence of AIDS or iatrogenic immunosuppression, then virus replication and subsequent pathogenic manifestations ensue. In the oral and maxillo-facial region, the virus causes a wide variety of diseases, mainly atypical chronic ulcerations and sialadenitis. These morbidities are rarely reported and sometimes cause significant problems for clinicians.
Doumas
S
S
Vladikas
A
A
Papagianni
M
M
Kolokotronis
A
A
D003587:Cytomegalovirus / Q000502:physiology*; D003586:Cytomegalovirus Infections; D005892:Gingivitis, Necrotizing Ulcerative / Q000821:virology*; D006801:Humans; D016867:Immunocompromised Host; D009140:Musculoskeletal Diseases / Q000821:virology*; D050721:Proto-Oncogene Proteins c-cbl; D012793:Sialadenitis / Q000821:virology*; D015022:Yugoslavia
D050721:Proto-Oncogene Proteins c-cbl; C067419:CBL protein, human