Adaptive effects of dexamethasone in stress exposure.
Disorders in the compensatory adaptive processes underlie the development of many somatic diseases. The neuroimmunoendocrine complex and one of its main components, the hypothalamic-pituitary-adrenal system, play the leading role in the maintenance of the adaptation reserve. Treatment with a synthetic analog of hydrocortisone (final effector of this system) in low doses modulates its function by inducing positive changes in the adaptive mechanisms under conditions of stress exposure.
Udut
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VV
Institute of Pharmacology, Tomsk Research Center, Siberian Division of Russian Academy of medical Sciences. evbor@hotbox.ru
Popova
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GA
Borodulina
E V
EV
D000222:Adaptation, Physiological; D000324:Adrenocorticotropic Hormone / Q000097:blood; D000328:Adult; D002940:Circadian Rhythm; D003907:Dexamethasone / Q000494:pharmacology*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007328:Insulin / Q000097:blood; D008297:Male; D013312:Stress, Physiological / Q000097:blood*
D007328:Insulin; D003907:Dexamethasone; D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone