title: Bone formation using human demineralised bone matrix (Grafton) for the treatment of bone cysts in children.
abstract: Bone cysts, in particular solitary bone cysts, are the most frequent cause of pathological fractures in children. However, there is still a great variety of regimens used to treat these lesions. Since demineralised bone matrix (DBM) is commercially available, we aimed to use this material for the consolidation of bones diagnosed as fragile because of cyst formation. Each of the 7 bone cysts as well as one enchondroma filled with DBM showed a continuous decrease in bone transparency over a period of two years (mean 8 months). A significant decrease in bone transparency and simultaneous cortical remodelling was radiographically detected in these cases as the specific hallmark of an initiated graft incorporation after 3 to 4 months. It was demonstrated that it is possible to heal children within an acceptable period of time using DBM to fill the cystic lesion. DBM appears to be a reasonable and beneficial alternative for the treatment of bone cysts offering both osteoinduction and osteoconductive features.
authors.affiliation: Department of Pediatric Surgery, University Hospital, Magdeburg, Germany. hans-juergen.hass@medizin.uni-magdeburg.de
authors.forename: H-J
authors.initials: HJ
authors.lastname: Hass
authors.forename: H
authors.initials: H
authors.lastname: Krause
authors.forename: S
authors.initials: S
authors.lastname: Kroker
authors.forename: W
authors.initials: W
authors.lastname: Wagemann
authors.forename: F
authors.initials: F
authors.lastname: Meyer
mesh_terms: D000293:Adolescent; D001845:Bone Cysts / Q000628:therapy*; D016723:Bone Remodeling / Q000187:drug effects*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005990:Glycerol / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D010012:Osteogenesis / Q000187:drug effects*; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: C497176:Grafton demineralized bone matrix gel; D005990:Glycerol