title: Bluetongue virus VP4 is an RNA-capping assembly line.
abstract: Eukaryotic organisms cap the 5' ends of their messenger RNAs by a series of four chemical reactions. Some viruses achieve this using a single molecule; the crystal structure of such an enzyme from bluetongue virus reveals an elongated modular architecture that provides a scaffold for an assemblage of active sites, two contributed by a domain of novel structure.
authors.affiliation: Division of Structural Biology, The Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Headington, Oxford, OX3 7BN, UK.
authors.forename: Geoff
authors.initials: G
authors.lastname: Sutton
authors.forename: Jonathan M
authors.initials: JM
authors.lastname: Grimes
authors.forename: David I
authors.initials: DI
authors.lastname: Stuart
authors.forename: Polly
authors.initials: P
authors.lastname: Roy
mesh_terms: D017766:Acid Anhydride Hydrolases / Q000737:chemistry*; D001665:Binding Sites; D001820:Bluetongue virus / Q000737:chemistry*; D018360:Crystallography, X-Ray; D008780:Methyltransferases / Q000737:chemistry*; D011487:Protein Conformation; D012315:RNA Caps; D012316:RNA Nucleotidyltransferases / Q000737:chemistry*; D012367:RNA, Viral / Q000378:metabolism
chemical_list: D012315:RNA Caps; D012367:RNA, Viral; D008780:Methyltransferases; C055097:mRNA (guanine(N7))-methyltransferase; C055099:mRNA (nucleoside-O(2'))-methyltransferase; D012316:RNA Nucleotidyltransferases; D017766:Acid Anhydride Hydrolases; C023090:RNA triphosphatase