Upper and lower system nasolacrimal duct stenosis secondary to paclitaxel.
A 66-year-old man underwent chemotherapy and radiation for angiosarcoma of the head and neck. Paclitaxel was used in his chemotherapeutic regimen. Two months post treatment with paclitaxel, he developed epiphora. He was found to have severe punctal and canalicular stenosis at the time of surgery.
McCartney
Emily
E
Wilmer Eye Institute, Division of Oculoplastic and Reconstructive Surgery, Johns Hopkins University, Baltimore, Maryland 21287-9237, USA. emccar12@jhmi.edu
Valluri
Shailaja
S
Rushing
Dan
D
Burgett
Richard
R
D000368:Aged; D003131:Combined Modality Therapy; D006258:Head and Neck Neoplasms / Q000188:drug therapy / Q000532:radiotherapy; D006394:Hemangiosarcoma / Q000188:drug therapy / Q000532:radiotherapy; D006801:Humans; D007767:Lacrimal Duct Obstruction / Q000139:chemically induced*; D008297:Male; D009301:Nasolacrimal Duct / Q000187:drug effects*; D017239:Paclitaxel / Q000009:adverse effects*; D050257:Tubulin Modulators / Q000009:adverse effects*
D050257:Tubulin Modulators; D017239:Paclitaxel