title: Induction of apoptosis in DLD-1 human colon cancer cells by peridinin isolated from the dinoflagellate, Heterocapsa triquetra.
abstract: Peridinin, which is uniquely present in dinoflagellates, is one of the most abundant carotenoids found in nature. We evaluated the apoptotic effect of peridinin on DLD-1 human colorectal cancer cells. Peridinin significantly reduced the cell viability in a dose-dependent manner (0-20 microM) and induced apoptosis by activating both caspase-8 and caspase-9. Our findings could be important for the high-performance utilization of marine bioproducts.
authors.affiliation: Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University, Kyoto, Japan. sugawara@kais.kyoto-u.ac.jp
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Sugawara
authors.forename: Kyoko
authors.initials: K
authors.lastname: Yamashita
authors.forename: Shota
authors.initials: S
authors.lastname: Sakai
authors.forename: Akira
authors.initials: A
authors.lastname: Asai
authors.forename: Akihiko
authors.initials: A
authors.lastname: Nagao
authors.forename: Tomotaka
authors.initials: T
authors.lastname: Shiraishi
authors.forename: Ichiro
authors.initials: I
authors.lastname: Imai
authors.forename: Takashi
authors.initials: T
authors.lastname: Hirata
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D002338:Carotenoids / Q000302:isolation & purification / Q000494:pharmacology*; D053181:Caspase 8 / Q000378:metabolism; D053453:Caspase 9 / Q000378:metabolism; D002467:Cell Nucleus / Q000187:drug effects / Q000648:ultrastructure; D002470:Cell Survival / Q000187:drug effects; D003110:Colonic Neoplasms / Q000188:drug therapy*; D004141:Dinoflagellida / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D004789:Enzyme Activation / Q000187:drug effects; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans
chemical_list: D000970:Antineoplastic Agents; C016040:peridinin; D002338:Carotenoids; D053181:Caspase 8; D053453:Caspase 9