A possible role for TSLP in inflammatory arthritis.
Thymic stromal lymphopoietin (TSLP) is an IL-7-like cytokine that triggers dendritic cell-mediated Th2-type inflammatory responses and is considered as a master switch for allergic inflammation. In this study, we found increased levels of TSLP and, also TNF-alpha as previously reported, in synovial fluid specimens derived from patients with rheumatoid arthritis (RA) when compared with those from patients with osteoarthritis (OA). In addition, TNF-alpha up-regulated TSLP expression in RA- and OA-derived synovial fibroblasts, which was inhibited by IFN-gamma. Furthermore, anti-TSLP neutralizing antibody ameliorated a TNF-alpha-dependent experimental arthritis induced by anti-type II collagen antibody in mice. Collectively, these results suggest that TSLP, as a downstream molecule of TNF-alpha, may be involved in the pathophysiology of inflammatory arthritis. TSLP might thus play a role not only in allergic diseases but also in inflammatory arthritis such as RA.
Koyama
Kensuke
K
Department of Immunology, Faculty of Medicine, University of Yamanashi, Chuo, Yamanashi 409-3898, Japan.
Ozawa
Tetsuro
T
Hatsushika
Kyosuke
K
Ando
Takashi
T
Takano
Shinichi
S
Wako
Masanori
M
Suenaga
Fumiko
F
Ohnuma
Yuko
Y
Ohba
Tetsuro
T
Katoh
Ryohei
R
Sugiyama
Hajime
H
Hamada
Yoshiki
Y
Ogawa
Hideoki
H
Okumura
Ko
K
Nakao
Atsuhito
A
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001172:Arthritis, Rheumatoid / Q000276:immunology*; D002478:Cells, Cultured; D016207:Cytokines / Q000276:immunology*; D005260:Female; D005347:Fibroblasts / Q000187:drug effects / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000276:immunology*; D013582:Synovial Fluid / Q000187:drug effects / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000008:administration & dosage* / Q000276:immunology*; D000094632:Thymic Stromal Lymphopoietin
D016207:Cytokines; D014409:Tumor Necrosis Factor-alpha; D000094632:Thymic Stromal Lymphopoietin