title: No association evidence between schizophrenia and dystrobrevin-binding protein 1 (DTNBP1) in Taiwanese families.
abstract: Several linkage studies have shown significant linkage of schizophrenia to chromosome 6p region, which includes the positional candidate genes, Dystrobrevin-binding protein 1 (DTNBP1). The aim was to examine the association evidence of the candidate gene in 693 Taiwanese families with at least two affected siblings of schizophrenia. We genotyped nine SNPs of this gene with average intermarker distance of 17 kb. Intermarker linkage disequilibrium was calculated with GOLD. Single locus and haplotype association analyses were performed with TRANSMIT program. We found no significant association between schizophrenia and DTNBP1 either through single locus or haplotype analyses. We failed to replicate the association evidence between DTNBP1 and schizophrenia and this gene may not play a major role in the etiology of schizophrenia in this Taiwanese family sample.
authors.affiliation: Department of Psychiatry, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
authors.forename: Chih-Min
authors.initials: CM
authors.lastname: Liu
authors.forename: Yu-Li
authors.initials: YL
authors.lastname: Liu
authors.forename: Cathy Shen-Jang
authors.initials: CS
authors.lastname: Fann
authors.forename: Wei-Chih
authors.initials: WC
authors.lastname: Yang
authors.forename: Jer-Yuarn
authors.initials: JY
authors.lastname: Wu
authors.forename: Shuen-Iu
authors.initials: SI
authors.lastname: Hung
authors.forename: Wei J
authors.initials: WJ
authors.lastname: Chen
authors.forename: Ching-Mo
authors.initials: CM
authors.lastname: Chueh
authors.forename: Wei-Ming
authors.initials: WM
authors.lastname: Liu
authors.forename: Chen-Chung
authors.initials: CC
authors.lastname: Liu
authors.forename: Ming-Hsien
authors.initials: MH
authors.lastname: Hsieh
authors.forename: Tzung-Jeng
authors.initials: TJ
authors.lastname: Hwang
authors.forename: Stephen V
authors.initials: SV
authors.lastname: Faraone
authors.forename: Ming T
authors.initials: MT
authors.lastname: Tsuang
authors.forename: Hai-Gwo
authors.initials: HG
authors.lastname: Hwu
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics*; D002352:Carrier Proteins / Q000235:genetics*; D002896:Chromosomes, Human, Pair 6; D000074765:Dysbindin; D049029:Dystrophin-Associated Proteins; D005260:Female; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000208:ethnology / Q000235:genetics*; D035781:Siblings / Q000523:psychology; D013624:Taiwan
chemical_list: D002352:Carrier Proteins; C432416:DTNBP1 protein, human; D000074765:Dysbindin; D049029:Dystrophin-Associated Proteins; D005819:Genetic Markers