Gene discovery in diabetic nephropathy.
Diabetic nephropathy affects approximately one third of diabetic patients and is the leading cause of end-stage renal disease. Identification of genetic susceptibility factors contributing to the development of diabetic nephropathy could facilitate prediction, development of improved treatments, and prevention of this devastating complication of diabetes. Although investigations to identify the causal genetic variants associated with diabetic nephropathy have been inconclusive, new approaches, including whole genome association scanning, offer hope for the future.
Savage
David A
DA
Nephrology Research Laboratory, Queen's University Belfast, Regional Genetics Centre, Belfast City Hospital, Lisburn Road, Belfast BT9 7AB, Northern Ireland. d.savage@qub.ac.uk
Bain
Stephen C
SC
McKnight
Amy Jayne
AJ
Maxwell
A Peter
AP
D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000235:genetics; D003928:Diabetic Nephropathies / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D015894:Genome, Human / Q000235:genetics; D006801:Humans