Nonconventional terror--the anesthesiologist's role in a nerve agent event.
The structure and biologic action of nerve agents is similar to organophosphates, commonly used as insecticides. Acetylcholine accumulation and binding to the cholinergic receptor site stimulates the affected organs producing a predictable set of clinical symptoms. Treatment of the affected patients will include decontamination, respiratory and hemodynamic support, as well as specific antidotes. The multiple casualties that may be expected present additional logistical and organizational problems. The specific skills of anesthesiologists will make them invaluable members of the care team in such a chemical mass casualty event.
Talmor
Daniel
D
Department of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, Harvard Medical School, 1 Deaconess Road, CC-470, Boston, MA 02215, USA. dtalmor@bidmc.harvard.edu
D000776:Anesthesiology; D051337:Chemical Terrorism; D002618:Chemical Warfare; D002619:Chemical Warfare Agents / Q000145:classification; D004189:Disaster Planning; D006801:Humans; D020258:Neurotoxicity Syndromes / Q000175:diagnosis / Q000517:prevention & control / Q000628:therapy*
D002619:Chemical Warfare Agents