[Potential prognostic value of angiogenesis, cell proliferation and metastasing in patients with surgically treated gastric cancer--current knowledge].
Gastric cancer is nowadays one of the most severe human malignant tumours. Surgeons and oncologists often encounter in their clinical practice the course of disease that cannot be fully accounted for by commonly used classical histo-clinical prognostic parameters. Gastric tumours of similar size, similar progression stage and similarly treated may develop along significantly different courses, the phenomenon that seems to depend on as yet not fully recognized biological factors. Preliminary observations from different centers concerning the role of new molecular parameters having potential influence on prognosis in gastric cancer are often contradictory. This study based on bibliography and own observations presents current data connected with potential prognostic value of angiogenesis, proliferation and metastasing in patients with surgically treated gastric cancer. It is very possible that in the future the evaluation of these molecular parameters will find its place in clinical practice for determination of more precise prognosis and improving distant results of combined treatment in gastric cancer patients.
Tenderenda
Michał
M
Kliniki Chirurgii Onkologicznej Katedry Onkologii Uniwersytetu Medycznego w Lodzi.
D018952:Antigens, CD34 / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis*; D002277:Carcinoma / Q000473:pathology / Q000556:secondary* / Q000601:surgery* / Q000628:therapy; D049109:Cell Proliferation; D003131:Combined Modality Therapy; D006801:Humans; D018960:Hyaluronan Receptors / Q000032:analysis; D019394:Ki-67 Antigen / Q000032:analysis; D009361:Neoplasm Invasiveness; D009389:Neovascularization, Pathologic; D011237:Predictive Value of Tests; D011379:Prognosis; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000098:blood supply* / Q000175:diagnosis / Q000601:surgery*
D018952:Antigens, CD34; D014408:Biomarkers, Tumor; D018960:Hyaluronan Receptors; D019394:Ki-67 Antigen