[Expression of fatty acid binding protein in human breast cancer tissues].
OBJECTIVE
To detect the expression pattern of fatty acid binding protein (FABP) in human breast cancer, and to find potential markers and therapeutic targets for breast cancer.


METHODS
adipocyte-FABP (A-FABP), heart or muscle FABP (H-FABP), brain-FABP (B-FABP), epidermis or psoriasis FABP (E-FABP), liver FABP (L-FABP), intestinal FABP (I-FABP) and gastro-FABP (G-FABP) expression in 35 ductal infiltrating carcinoma and 16 fibroadenoma of breast were detected by RT-PCR, immunohistochemical staining and Western blot analysis, respectively.


RESULTS
E-, L-, and H-FABP were up regulated significantly in ductal infiltrating carcinoma when compared with those in benign tissue (P<0.05). However, there were not significant difference in A-, B-, G-, and I-FABP expression between ductal infiltrating carcinoma and benign tissue (P>0.05). Interestingly, H-FABP was not only found in benign tissues but in some of ductal infiltrating carcinomas, furthermore, H-FABP level was elevated in malignant tissue, compared with that in benign tissue.


CONCLUSIONS
E-, L-, and H-FABP may play a key role in the progress of invasiveness and metastasis in human breast cancer. Furthermore, the secretion of these FABPs has the potential to serve as a diagnostic marker for breast cancer.
Li
Hua
H
Department of Human Anatomy, School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, China.
Lu
Qing
Q
Dong
Li-Hua
LH
Xue
Hui
H
Zhou
Hong-Ying
HY
Yang
Hui-Jun
HJ
D000328:Adult; D000368:Aged; D015153:Blotting, Western; D001943:Breast Neoplasms / Q000378:metabolism*; D044584:Carcinoma, Ductal / Q000235:genetics / Q000378:metabolism; D050556:Fatty Acid-Binding Proteins / Q000235:genetics* / Q000378:metabolism*; D005260:Female; D018226:Fibroadenoma / Q000235:genetics / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D020133:Reverse Transcriptase Polymerase Chain Reaction
D050556:Fatty Acid-Binding Proteins