Long-term survival of a patient with small cell lung cancer associated with cancer-associated retinopathy.
Cancer-associated retinopathy (CAR) is a rare paraneoplastic disorder that is frequently found in patients with small cell lung cancer (SCLC); it is caused by autoantibody to the 23-kDa photoreceptor protein, recoverin. We report a 9-year survivor of SCLC after concurrent chemoradiotherapy. His anti-recoverin antibody remains positive. Long-term survival without SCLC recurrence might be related to an autoimmunity mechanism that causes CAR due to the presence of anti-recoverin antibody cross-reacting with retinal cells and tumor cells. The current literature review was conducted to evaluate the impact on overall survival according to anti-recoverin antibody status.
Kobayashi
Makoto
M
Department of Hematology and Respiratory Medicine, Kochi Medical School, Kochi University, Nankoku, Kochi 783-8505, Japan. kmakoto@kochi-u.ac.jp
Ikezoe
Takayuki
T
Uemura
Yoshiki
Y
Ueno
Hisayuki
H
Taguchi
Hirokuni
H
D000368:Aged; D001327:Autoimmune Diseases / Q000276:immunology / Q000401:mortality* / Q000473:pathology; D018288:Carcinoma, Small Cell / Q000150:complications / Q000401:mortality* / Q000473:pathology; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications / Q000401:mortality* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012164:Retinal Diseases / Q000276:immunology / Q000401:mortality* / Q000473:pathology; D016019:Survival Analysis