A fully automated robotic system for high throughput fermentation.
High throughput robotic systems have been used since the 1990s to carry out biochemical assays in microtiter plates. However, before the application of such systems in industrial fermentation process development, some important specific demands should be taken into account. These are sufficient oxygen supply, optimal growth temperature, minimized sample evaporation, avoidance of contaminations, and simple but reliable process monitoring. A fully automated solution where all these aspects have been taken into account is presented.
Zimmermann
Hartmut F
HF
Degussa AG, Creavis Technologies & Innovation, Hanau, Wolfgang, Germany. hartmut.zimmermann@degussa.com <hartmut.zimmermann@degussa.com>
Rieth
Jochen
J
D001331:Automation / Q000295:instrumentation / Q000379:methods*; D005285:Fermentation; D007218:Industrial Microbiology / Q000295:instrumentation* / Q000379:methods; D012371:Robotics / Q000295:instrumentation* / Q000379:methods*; D012441:Saccharomyces cerevisiae / Q000378:metabolism