title: [Chronic intestinal pseudo-obstruction].
abstract: Chronic intestinal pseudo-obstruction (CIPO) is a syndrome characterized by the presence of recurrent episodes of clinical intestinal obstruction in the absence of obstructive lesions. Although this syndrome is rare, it causes a high morbidity. It is caused by a disturbance of the intestinal motility, that results in a failure of the progression of the intestinal content. Basically, the failure of the intestinal motility is a consequence of muscular disorder, neurological disorder or both. Usually, CIPO is secondary to other systemic disease; however, in the last years, many cases of primary CIPO have been described. The use of new manometric tecniques and specific histological procedures have allowed to clarify the pathogenesis of some of these entities including mitochondrial diseases and paraneoplasic syndromes. Clinical manifestations of CIPO are diverse, depending on the location and extension of the motility disorder. As the diagnosis of this disease is usually not an easy task, patients frecuently undergo unnecesary surgical interventions, are diagnosed of psyquiatric disorders, or the correct diagnosis is delayed several years after the first symptoms arise. The aims of the treatment are to maintain the nutritional condition and to improve symptoms using nutritional measures, drugs or, eventually, endoscopical or surgical procedures.
authors.affiliation: Servicio de Medicina de Aparato Digestivo, Hospital Universitario 12 de Octubre, Madrid. tmunoz.hdoc@salud.madrid.org
authors.forename: M T
authors.initials: MT
authors.lastname: Muñoz
authors.forename: J A
authors.initials: JA
authors.lastname: Solís Herruzo
mesh_terms: D002908:Chronic Disease; D020117:Cisapride / Q000627:therapeutic use; D019587:Dietary Supplements; D004724:Endoscopy; D005765:Gastrointestinal Agents / Q000627:therapeutic use; D006801:Humans; D007418:Intestinal Pseudo-Obstruction / Q000145:classification / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000209:etiology / Q000601:surgery / Q000628:therapy; D009752:Nutritional Status; D015282:Octreotide / Q000627:therapeutic use; D010166:Palliative Care; D011379:Prognosis; D011860:Radiography, Abdominal; D014057:Tomography, X-Ray Computed
chemical_list: D005765:Gastrointestinal Agents; D015282:Octreotide; D020117:Cisapride