title: Local anaesthetic block of sodium channels: raising the barrier.
authors.affiliation: Department of Pharmacology, Mailstop 357280, University of Washington, Seattle, WA 98195-7280, USA. scheuer@u.washington.edu
authors.forename: Todd
authors.initials: T
authors.lastname: Scheuer
mesh_terms: D000779:Anesthetics, Local / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D000818:Animals; D001665:Binding Sites; D002463:Cell Membrane Permeability / Q000187:drug effects*; D006801:Humans; D015640:Ion Channel Gating / Q000187:drug effects*; D008012:Lidocaine / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D008564:Membrane Potentials / Q000187:drug effects; D008958:Models, Molecular; D015394:Molecular Structure; D009124:Muscle Proteins / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D062554:NAV1.5 Voltage-Gated Sodium Channel; D010649:Phenylalanine; D011487:Protein Conformation; D026941:Sodium Channel Blockers / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D015222:Sodium Channels / Q000737:chemistry / Q000235:genetics / Q000378:metabolism
chemical_list: D000779:Anesthetics, Local; D009124:Muscle Proteins; D062554:NAV1.5 Voltage-Gated Sodium Channel; C568320:SCN5A protein, human; D026941:Sodium Channel Blockers; D015222:Sodium Channels; D010649:Phenylalanine; D008012:Lidocaine