[Relation between cytochrome P450 2D6 and lung cancer susceptibility caused by smoking].
Cytochrome P450 2D6(CYP2D6) is one of the prominent phase I metabolizing enzymes in hepatic tissue, and is responsible for metabolically activating the tobacco-specific nitrosamine such as NNK and nicotinamide to highly reactive metabolites, so it may play a role in lung cancer. The study of its biological characters, structure function and the relationship beween CYP2D6 genetic polymorphisms and lung cancer susceptibility can redound to understand the significant influence of CYP2D6 on lung cancer susceptibility. Furthermore from the point of view of interaction between gene and environment it can evaluate the lung cancer risk accurately.
Yan
Zhen
Z
School of Public Health, Zhengzhou University, Zhengzhou 450001, China. yanzhen@gs.zzu.edu.cn
Wu
Yongjun
Y
Wu
Yiming
Y
D019389:Cytochrome P-450 CYP2D6 / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D008175:Lung Neoplasms / Q000209:etiology* / Q000235:genetics* / Q000378:metabolism; D009536:Niacinamide / Q000378:metabolism; D009602:Nitrosamines / Q000378:metabolism; D011110:Polymorphism, Genetic; D012907:Smoking / Q000009:adverse effects* / Q000378:metabolism
D009602:Nitrosamines; D009536:Niacinamide; D019389:Cytochrome P-450 CYP2D6