Cutaneous involvement with Burkitt-like lymphoma.
We report a case of a 27-year-old woman with a known history of Burkitt-like lymphoma (BLL), who presented with a rapidly enlarging nodule in the suprapubic area. Skin biopsy of the suprapubic nodule was consistent with cutaneous involvement of BLL. BLL is a highly aggressive B-cell lymphoma with a high proliferative rate. Like Burkitt lymphoma, BLL is characterized by a translocation of the c-MYC proto-oncogene. Histopathologic characteristics are considered borderline between those of classic Burkitt lymphoma and diffuse large B-cell lymphoma. Cutaneous involvement of BLL is rare and poorly documented in the literature.
Pettey
Adam A
AA
Mayo Clinic, Jacksonville, FL 32224, USA.
Walsh
John S
JS
D000328:Adult; D002051:Burkitt Lymphoma / Q000235:genetics / Q000276:immunology / Q000473:pathology*; D051925:CD79 Antigens / Q000032:analysis; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D016259:Genes, myc; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000032:analysis; D008214:Lymphocytes / Q000276:immunology / Q000473:pathology; D016403:Lymphoma, Large B-Cell, Diffuse / Q000235:genetics / Q000276:immunology / Q000473:pathology*; D009361:Neoplasm Invasiveness; D000090063:Proto-Oncogene Mas; D012878:Skin Neoplasms / Q000235:genetics / Q000276:immunology / Q000473:pathology*; D014178:Translocation, Genetic
D051925:CD79 Antigens; C497881:CD79A protein, human; D019394:Ki-67 Antigen; C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas