Lipodystrophy and dyslipidemia in human immunodeficiency virus-infected Thai patients receiving antiretroviral therapy.
BACKGROUND
Lipodystrophy and dyslipidemia are increasing problems in HIV-infected patients receiving antiretroviral therapy (ART).


OBJECTIVE
Determine the prevalence and predicting factors for lipodystrophy and dyslipidemia in these patients.


METHODS
A cross-sectional study was performed on HIV-infected patients receiving ART in January 2006. Clinical assessment for lipodystrophy and blood tests for lipid profile were obtained.


RESULTS
There were 56 patients with a mean age of 42.3 years and 71.4% were male. Lipodystrophy was detected in 66.1%. Baseline characteristics between patients with and without lipodystrophy were similar except for age, history of receiving d4T and undetectable HIV-RNA (p < 0. 05). There was a high prevalence of dyslipidemia (53.6%). By logistic regression, undetectable HIV-RNA (odds ratio (OR) 6.4, p = 0.016) and receiving d4T (OR 7.4, p = 0.022) are predicting factors for lipodystrophy.


CONCLUSIONS
Lipodystrophy and dyslipidemia in HIV-infected Thai patients receiving ART are common. Clinical monitoring for these abnormalities during ART is highly recommended.
Chuapai
Yaowaluk
Y
Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Thailand.
Kiertiburanakul
Sasisopin
S
Malathum
Kumthorn
K
Sungkanuparph
Somnuek
S
D000328:Adult; D044966:Anti-Retroviral Agents / Q000009:adverse effects*; D003430:Cross-Sectional Studies; D050171:Dyslipidemias / Q000139:chemically induced* / Q000453:epidemiology; D005260:Female; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D008060:Lipodystrophy / Q000139:chemically induced* / Q000453:epidemiology; D008297:Male; D015995:Prevalence; D013785:Thailand
D044966:Anti-Retroviral Agents