title: Mutant presenilin 2 increased oxidative stress and p53 expression in neuronal cells.
abstract: The learning and memory impairment of presenilin 2 transgenic mice was mentioned previously. In this study, exposing the presenilin 2 transfected PC12 cells to the 50 microM Abeta(25-35), 30 mM l-glutamate and 50 microM H(2)O(2) resulted in significant increase 8-oxodG and p53 levels of the cells expressing the mutant gene. The increase was also found in the mutant presenilin 2 transgenic mice brains age-dependently in comparison to that in the wild-type presenilin 2-transgenic mice and non-transgenic ones. These findings indicated that mutant presenilin 2 clearly increases oxidative stress and p53 expression, which could be implicated in promoting mutant presenilin 2-induced neurodegeneration in Alzheimer's disease, and the influence of mutant presenilin 2 in Alzheimer's disease may be brain regional and age related effects.
authors.affiliation: College of Pharmacy, CBITRC, Chungbuk National University, 12, Gaeshin-dong, Heungduk-gu, Cheongju, Chungbuk 361-763, Republic of Korea.
authors.forename: Hong Nga
authors.initials: HN
authors.lastname: Nguyen
authors.forename: Moon Soon
authors.initials: MS
authors.lastname: Lee
authors.forename: Dae Youn
authors.initials: DY
authors.lastname: Hwang
authors.forename: Young Kyu
authors.initials: YK
authors.lastname: Kim
authors.forename: Do Young
authors.initials: DY
authors.lastname: Yoon
authors.forename: Jae Woong
authors.initials: JW
authors.lastname: Lee
authors.forename: Yeo Pyo
authors.initials: YP
authors.lastname: Yun
authors.forename: Myung Koo
authors.initials: MK
authors.lastname: Lee
authors.forename: Ki Wan
authors.initials: KW
authors.lastname: Oh
authors.forename: Jin Tae
authors.initials: JT
authors.lastname: Hong
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism*; D000818:Animals; D009154:Mutation; D009474:Neurons / Q000378:metabolism*; D018384:Oxidative Stress; D016716:PC12 Cells; D053766:Presenilin-2 / Q000235:genetics / Q000378:metabolism*; D051381:Rats; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
chemical_list: D053766:Presenilin-2; D016159:Tumor Suppressor Protein p53