title: [Reactive hemophagocytic syndrome in critical care patients. Report of 4 cases].
abstract: Reactive hemophagocytic syndrome or hemophagocytic lymphohistiocytosis comprises a variety of disorders, many of them associated with infection. It is characterized by hemophagocytosis, with cytopenia involving at least two cellular lines, increase in cytokines and serum ferritin. The clinical course resembles sepsis, sharing similar physiopathological features. We propose that hemophagocytic syndrome is an underdiagnosed entity in the critical care setting; simple tests aid to identify which patients should undergo diagnostic procedures. We discuss current therapeutic approaches.
authors.affiliation: Servicio de Terapia Intensiva, Hospital Alemán, Buenos Aires, Argentina. sterapiaintensiva@hospitalaleman.org
authors.forename: Maria Mercedes
authors.initials: MM
authors.lastname: Kleinert
authors.forename: Gonzalo
authors.initials: G
authors.lastname: Garate
authors.forename: Javier
authors.initials: J
authors.lastname: Osatnik
authors.forename: Juan
authors.initials: J
authors.lastname: Cicco
authors.forename: Barbara
authors.initials: B
authors.lastname: Hunter
authors.forename: Elisa J
authors.initials: EJ
authors.lastname: Soria
mesh_terms: D000328:Adult; D000368:Aged; D003422:Critical Care; D016207:Cytokines / Q000097:blood; D017809:Fatal Outcome; D005293:Ferritins / Q000097:blood; D006801:Humans; D051359:Lymphohistiocytosis, Hemophagocytic / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D008262:Macrophage Activation / Q000502:physiology; D008297:Male; D008875:Middle Aged; D018805:Sepsis / Q000473:pathology; D013577:Syndrome
chemical_list: D016207:Cytokines; D005293:Ferritins