[Role of matrix metalloproteinase-3 in joint destruction in rheumatoid arthritis].
Matrix metalloproteinase-3 (MMP-3) , which is induced by inflammatory cytokines such as interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF-alpha) in rheumatoid synovium, degrades a number of extracellular matrix components of cartilage, and plays central roles in rheumatoid joint destruction. In addition, serum MMP-3 level is a clinically useful maker for predicting joint destruction and for disease activity in rheumatoid arthritis (RA) . In this review, I summarized the role of MMP-3 in rheumatoid joint destruction, and clinical usefulness of serum MMP-3 level as a laboratory marker in RA.
Sugiyama
Eiji
E
University of Toyama, Graduate school of Medicine and Pharmaceutical Sciences for Research.
D000818:Animals; D001172:Arthritis, Rheumatoid / Q000175:diagnosis* / Q000209:etiology* / Q000473:pathology; D015415:Biomarkers / Q000097:blood; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism; D007375:Interleukin-1 / Q000378:metabolism; D007596:Joints / Q000473:pathology*; D019278:Matrix Metalloproteinase 3 / Q000097:blood / Q000502:physiology*; D011379:Prognosis; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D015415:Biomarkers; D018836:Inflammation Mediators; D007375:Interleukin-1; D014409:Tumor Necrosis Factor-alpha; D019278:Matrix Metalloproteinase 3