title: [Features of expression and functional activity of P2X7 receptors in bone marrow cells under the action of doxorubicin].
abstract: Mechanisms of the myelotoxic action of doxorubicin associated with changes in the expression and functional activity of P2X7 receptors have been assessed. The acute and subacute exposure of bone marrow cells to doxorubicin in vivo changed the expression of P2X7, altered the intracellular and extracellular ATP concentrations, and modulated the process of programmed cell death. These changes were associated with transformed susceptibility of hemopoietic cells to the apoptogenic action of ATP. Various possible mechanisms of realization of the apoptogenic action of ATP during acute and subacute exposure to doxorubicin are discussed.
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Uspenskaia
authors.forename: A B
authors.initials: AB
authors.lastname: Salmina
authors.forename: N A
authors.initials: NA
authors.lastname: Malinovskaia
authors.forename: N S
authors.initials: NS
authors.lastname: Mantorova
authors.forename: E F
authors.initials: EF
authors.lastname: Vaĭs
authors.forename: L A
authors.initials: LA
authors.lastname: Kushnir
authors.forename: A D
authors.initials: AD
authors.lastname: Klimova
mesh_terms: D000255:Adenosine Triphosphate / Q000032:analysis / Q000378:metabolism; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000633:toxicity*; D017209:Apoptosis; D001854:Bone Marrow Cells / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism; D004317:Doxorubicin / Q000633:toxicity*; D015227:Lipid Peroxidation; D008297:Male; D051379:Mice; D018048:Receptors, Purinergic P2 / Q000032:analysis / Q000378:metabolism*; D058486:Receptors, Purinergic P2X7
chemical_list: D000903:Antibiotics, Antineoplastic; C546469:P2rx7 protein, mouse; D018048:Receptors, Purinergic P2; D058486:Receptors, Purinergic P2X7; D004317:Doxorubicin; D000255:Adenosine Triphosphate