title: Ferulic acid supplementation prevents trimethyltin-induced cognitive deficits in mice.
abstract: This study's objective was to clarify the ameliorative effects ferulic acid (4-hydroxy-3-methoxycinnamic acid) has against cognitive deficits and ChAT activation in trimethyltin (TMT) induced, memory injured mice following a 28-d ferulic acid treatment. After administering TMT for 3 d, each mouse performed Y-maze and passive avoidance tests to check immediate working memory performance and cognitive function. The results showed that ferulic acid administration attenuated TMT-induced memory injury and a decline in ChAT activity in the mice. This suggests that ferulic acid might be useful for preventing cognitive dysfunction as well as for boosting the activation of ChAT in dementia.
authors.affiliation: Graduate School of Life Sciences and Biotechnology, Korea University, Seoul, Korea.
authors.forename: Mi Jeong
authors.initials: MJ
authors.lastname: Kim
authors.forename: Soo Jung
authors.initials: SJ
authors.lastname: Choi
authors.forename: Seung-Taik
authors.initials: ST
authors.lastname: Lim
authors.forename: Hye Kyung
authors.initials: HK
authors.lastname: Kim
authors.forename: Ho Jin
authors.initials: HJ
authors.lastname: Heo
authors.forename: Eun-Ki
authors.initials: EK
authors.lastname: Kim
authors.forename: Woo Jin
authors.initials: WJ
authors.lastname: Jun
authors.forename: Hong Yon
authors.initials: HY
authors.lastname: Cho
authors.forename: Young Jun
authors.initials: YJ
authors.lastname: Kim
authors.forename: Dong-Hoon
authors.initials: DH
authors.lastname: Shin
mesh_terms: D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000201:enzymology; D002795:Choline O-Acetyltransferase / Q000378:metabolism; D003072:Cognition Disorders / Q000139:chemically induced* / Q000517:prevention & control* / Q000523:psychology; D003373:Coumaric Acids / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000494:pharmacology*; D008297:Male; D008568:Memory / Q000187:drug effects; D051379:Mice; D008813:Mice, Inbred ICR; D014298:Trimethyltin Compounds / Q000037:antagonists & inhibitors* / Q000633:toxicity*
chemical_list: D003373:Coumaric Acids; D016166:Free Radical Scavengers; D014298:Trimethyltin Compounds; C004999:ferulic acid; D002795:Choline O-Acetyltransferase