title: NADPH diaphorase reactive neurons in temporal lobe cortex of patients with intractable epilepsy and hippocampal sclerosis.
abstract: Several studies have demonstrated a controversial involvement of NO in epileptogenesis. The aim of this study is to compare the NADPH diaphorase (NADPH-d) reactivity in the temporal cortex between surgical specimens of patients with intractable epilepsy and hippocampal sclerosis and autopsy controls. Brain samples of patients and postmortem controls were stained with the NADPH-d technique. Sprouting and larger areas of NADPH-d reactive neurons were found in the temporal cortex of epileptic patients.
authors.affiliation: Buenos Aires University, Institute of Molecular Biology, E de Robertis, Ramos Mejia Hospital, Epilepsy Center, Urquiza 609, Capital Federal, Buenos Aires 1201, Argentina. ldalessio@intramed.net.ar <ldalessio@intramed.net.ar>
authors.forename: Luciana
authors.initials: L
authors.lastname: D'Alessio
authors.forename: Juan José
authors.initials: JJ
authors.lastname: López-Costa
authors.forename: Héctor
authors.initials: H
authors.lastname: Konopka
authors.forename: Damián
authors.initials: D
authors.lastname: Consalvo
authors.forename: Eduardo
authors.initials: E
authors.lastname: Seoane
authors.forename: María Esther
authors.initials: ME
authors.lastname: López
authors.forename: María Laura
authors.initials: ML
authors.lastname: Guelman
authors.forename: Silvia
authors.initials: S
authors.lastname: Kochen
authors.forename: Luis María
authors.initials: LM
authors.lastname: Zieher
mesh_terms: D000368:Aged; D004351:Drug Resistance; D004569:Electroencephalography; D004827:Epilepsy / Q000188:drug therapy / Q000201:enzymology* / Q000473:pathology; D005260:Female; D006624:Hippocampus / Q000201:enzymology* / Q000473:pathology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D009252:NADPH Dehydrogenase / Q000378:metabolism*; D009474:Neurons / Q000201:enzymology* / Q000473:pathology; D009569:Nitric Oxide / Q000378:metabolism; D012598:Sclerosis; D013702:Temporal Lobe / Q000201:enzymology* / Q000473:pathology; D016610:Tissue Embedding
chemical_list: D009569:Nitric Oxide; D009252:NADPH Dehydrogenase