[Free radicals in Carassius auratus liver: their generation and oxidative stress induced by 2,4,6-trichlorophenol].
With electron paramagnetic resonance (EPR) technique, this paper studied the free radicals generation and oxidative stress in Carassius auratus liver after 4, 8, 12, 24 and 72 hours of 2, 4,6-trichlorophenol (2,4,6-TCP) intraperitoneal injection. The results showed that 2,4,6-TCP significantly promoted the generation of free radicals in C. auratus liver. The superoxide dismutase (SOD) and glutathione-S-transferase (GST) activities were induced significantly, while catalase (CAT) activity was inhibited, and glutathione (GSH) content had little difference with the control. A significant increase was observed in the contents of oxidized glutathione (GSSG) and malondialdehyde (MDA).
Ji
Liang-liang
LL
School of Resources and Environment, Liaoning University, Shenyang 110036, China. jiliangliang82@163.com
Li
Fa-yun
FY
Luo
Yi
Y
Ma
Xi-ping
XP
Chen
Zhong-lin
ZL
D000818:Animals; D002374:Catalase / Q000378:metabolism; D002733:Chlorophenols / Q000633:toxicity*; D004578:Electron Spin Resonance Spectroscopy; D005982:Glutathione Transferase / Q000378:metabolism; D006054:Goldfish / Q000378:metabolism*; D008099:Liver / Q000201:enzymology*; D018384:Oxidative Stress / Q000187:drug effects*; D013482:Superoxide Dismutase / Q000378:metabolism
D002733:Chlorophenols; D002374:Catalase; D013482:Superoxide Dismutase; D005982:Glutathione Transferase; C024564:2,4,6-trichlorophenol