title: A dimeric lactone from Ardisia japonica with inhibitory activity for HIV-1 and HIV-2 ribonuclease H.
abstract: A new dimeric lactone, ardimerin digallate (1), was isolated from the whole plants of Ardisia japonica, along with six known constituents. The structure of 1 was established on the basis of spectroscopic analysis including 1D- and 2D-NMR techniques. Compound 1 inhibited HIV-1 and HIV-2 RNase H in vitro with IC50 values of 1.5 and 1.1 microM, respectively.
authors.affiliation: College of Pharmacy, Chungnam National University, Daejeon 305-764, Korea.
authors.forename: Nguyen Tien
authors.initials: NT
authors.lastname: Dat
authors.forename: KiHwan
authors.initials: K
authors.lastname: Bae
authors.forename: Antony
authors.initials: A
authors.lastname: Wamiru
authors.forename: James B
authors.initials: JB
authors.lastname: McMahon
authors.forename: Stuart F J
authors.initials: SF
authors.lastname: Le Grice
authors.forename: Marion
authors.initials: M
authors.lastname: Bona
authors.forename: John A
authors.initials: JA
authors.lastname: Beutler
authors.forename: Young Ho
authors.initials: YH
authors.lastname: Kim
mesh_terms: D019380:Anti-HIV Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D031644:Ardisia / Q000737:chemistry*; D015497:HIV-1 / Q000201:enzymology*; D015498:HIV-2 / Q000201:enzymology*; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*; D016914:Ribonuclease H / Q000037:antagonists & inhibitors*
chemical_list: D019380:Anti-HIV Agents; D007783:Lactones; C521075:ardimerin digallate; D016914:Ribonuclease H