title: Midterm outcomes of paclitaxel-eluting stents for the treatment of intracranial posterior circulation stenoses.
abstract: OBJECTIVE
  Symptomatic intracranial vertebral and basilar artery atherosclerotic stenoses carry a high risk of stroke and permanent disability if refractory to maximal medical therapy. The authors conducted a study to determine the technical feasibility and midterm clinical and angiographic outcomes in patients in whom paclitaxel-eluting stents were placed for the treatment of symptomatic intracranial posterior circulation stenoses.
  
  
  METHODS
  A retrospective review of medical records and imaging studies was performed for 13 consecutive patients in whom paclitaxel-coated stents were used to treat symptomatic posterior circulation intracranial stenoses between 2002 and 2005. Clinical follow-up data were supplemented by telephone interviews. The technical success rate for stent placement was 100%. One patient (8%) suffered a periprocedural stroke. Twelve patients (92%) underwent clinical follow up for a minimum of 3 months postsurgery, and 11 (92%) of these patients remained asymptomatic after a mean period of 10.9 months. Nine patients (69%) underwent catheter angiographic follow up, and no patient had significant in-stent recurrence of stenosis after a mean period of 5.4 months.
  
  
  CONCLUSIONS
  Treatment of intracranial posterior circulation stenoses with drug-eluting stents is technically feasible, and the rate of clinically significant periprocedural complications is low. Rates of stenosis recurrence are reduced compared with those of bare-metal stents in the midterm. Midterm clinical outcome is excellent; no symptom recurrence was observed in this patient cohort.
authors.affiliation: Department of Radiology, Royal North Shore Hospital, Sydney, Australia.
authors.forename: Brendan
authors.initials: B
authors.lastname: Steinfort
authors.forename: Perry P
authors.initials: PP
authors.lastname: Ng
authors.forename: Kenneth
authors.initials: K
authors.lastname: Faulder
authors.forename: Timothy
authors.initials: T
authors.lastname: Harrington
authors.forename: Verity
authors.initials: V
authors.lastname: Grinnell
authors.forename: William
authors.initials: W
authors.lastname: Sorby
authors.forename: Michael K
authors.initials: MK
authors.lastname: Morgan
mesh_terms: D000328:Adult; D000368:Aged; D017130:Angioplasty; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D017239:Paclitaxel / Q000008:administration & dosage*; D012189:Retrospective Studies; D015607:Stents; D013997:Time Factors; D016896:Treatment Outcome; D050257:Tubulin Modulators / Q000008:administration & dosage*; D014715:Vertebrobasilar Insufficiency / Q000601:surgery*
chemical_list: D050257:Tubulin Modulators; D017239:Paclitaxel