title: HUM5007, a novel combination of thermogenic compounds, and 3-acetyl-7-oxo-dehydroepiandrosterone: each increases the resting metabolic rate of overweight adults.
abstract: This study tested the hypothesis that 3-acetyl-7-oxo-dehydroepiandrosterone alone (7-Keto) and in combination with calcium citrate, green tea extract, ascorbic acid, chromium nicotinate and cholecalciferol (HUM5007) will increase the resting metabolic rate (RMR) of overweight subjects maintained on a calorie-restricted diet. In this randomized, double-blind, placebo-controlled, crossover trial, overweight adults on a calorie-restricted diet were randomized to three 7-day treatment periods with 7-Keto, HUM5007 or placebo. Resting metabolic rate was measured by indirect calorimetry at the beginning and end of each treatment period with a 7-day washout between testing periods. Of 45 subjects enrolled, 40 completed the study (30 women, 10 men; mean age, 38.5 years; mean mass index, 32.0 kg/m(2)). During the placebo treatment, RMR decreased by 3.9% (75+/-111 kcal/day; mean+/-S.D.); however, RMR increased significantly by 1.4% (21+/-115 kcal/day) and 3.4% (59+/-118 kcal/day) during the 7-Keto and HUM5007 treatment periods, respectively (each compared to placebo, P=.001). No significant differences were found between the treatment periods with respect to compliance or adverse events. In this study, the administration of HUM5007 or 7-Keto reversed the decrease in RMR normally associated with dieting. HUM5007 and 7-Keto increased RMR above basal levels and may benefit obese individuals with impaired energy expenditure. HUM5007 and 7-Keto were generally well tolerated and no serious adverse events were reported.
authors.affiliation: Department of Clinical Affairs, Minnesota Applied Research Center, Edina, MN 55435, USA. john@zenk.net
authors.forename: John L
authors.initials: JL
authors.lastname: Zenk
authors.forename: Joy L
authors.initials: JL
authors.lastname: Frestedt
authors.forename: Michael A
authors.initials: MA
authors.lastname: Kuskowski
mesh_terms: D000328:Adult; D001205:Ascorbic Acid / Q000008:administration & dosage / Q000494:pharmacology*; D001481:Basal Metabolism / Q000187:drug effects*; D031204:Caloric Restriction; D028241:Camellia sinensis; D002762:Cholecalciferol / Q000008:administration & dosage / Q000494:pharmacology*; D003687:Dehydroepiandrosterone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D004311:Double-Blind Method; D004338:Drug Combinations; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009539:Nicotinic Acids / Q000008:administration & dosage / Q000494:pharmacology*; D009942:Organometallic Compounds / Q000008:administration & dosage / Q000494:pharmacology; D050177:Overweight; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: C524254:3-acetyl-7-oxodehydroepiandrosterone; D004338:Drug Combinations; C524255:HUM 5007; D009539:Nicotinic Acids; D009942:Organometallic Compounds; D010936:Plant Extracts; C465546:green tea extract AR25; D002762:Cholecalciferol; D003687:Dehydroepiandrosterone; C102874:chromium nicotinic acid complex; D001205:Ascorbic Acid