Early impairment of synaptic plasticity in patients with Down's syndrome.
We investigated synaptic plasticity in persons with Down' syndrome (DS) and control subjects used paired associative stimulation (PAS) protocol, a paradigm capable of producing long-term potentiation (LTP)-like changes in the sensorimotor system. After PAS, patients showed less LTP-like plasticity compared to control subjects. Abnormal motor cortex synaptic plasticity may play a role in the development of motor signs in DS.
Battaglia
Fortunato
F
CUNY School of Medicine, Department of Physiology and Pharmacology, 138th Street & Convent Avenue, Room D-210, New York, NY 10031, United States. fb@med.cuny.edu
Quartarone
Angelo
A
Rizzo
Vincenzo
V
Ghilardi
Maria Felice
MF
Di Rocco
Alessandro
A
Tortorella
Gaetano
G
Girlanda
Paolo
P
D000293:Adolescent; D002540:Cerebral Cortex / Q000503:physiopathology*; D004314:Down Syndrome / Q000503:physiopathology*; D005260:Female; D006801:Humans; D017774:Long-Term Potentiation; D008297:Male; D009473:Neuronal Plasticity; D009435:Synaptic Transmission