Protective effect of energy metabolism regulators in alteration of gravitation load under experimental conditions.
Mitochondrial substrate-based preparations corrected disorders, caused by long-term exposure to abnormal gravitation vector in head-down tilt (hanging) test in rats. The preparations produced systemic and polyorgan protective effects consisting in correction of the blood prooxidant/antioxidant balance, energy metabolism in musculus soleus, and minimization of morphological changes in the liver and kidneys.
Mazina
N K
NK
Institute of Biomedical Problems, Russian Academy of Sciences, Moscow.
Larina
I M
IM
Khazanov
V A
VA
Shenkman
B S
BS
Tsapok
P I
PI
Zaitsev
V B
VB
Khorobrykh
V G
VG
Veselova
O M
OM
Tret'yakov
V S
VS
D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D004734:Energy Metabolism / Q000187:drug effects; D006112:Gravitation; D018475:Head-Down Tilt; D008293:Malates / Q000494:pharmacology; D008297:Male; D008928:Mitochondria / Q000378:metabolism*; D016877:Oxidants / Q000097:blood; D051381:Rats; D017208:Rats, Wistar; D019802:Succinic Acid / Q000494:pharmacology
D000975:Antioxidants; D008293:Malates; D016877:Oxidants; C030298:malic acid; D019802:Succinic Acid