Feeding flaxseed oil but not secoisolariciresinol diglucoside results in higher bone mass in healthy rats and rats with kidney disease.
Flaxseed's oil and lignan, secoisolariciresinol diglucoside (SDG), are implicated in attainment of health and treatment of renal injury and osteoporosis. To test for these benefits, weanling Han:SPRD-cy rats (n=171) with or without kidney disease were randomized to diets made with either corn oil or flaxseed oil and with or without SDG for 12 weeks. In females, weight was lower with the SDG diet. In males fed flaxseed oil, lean mass was higher and fat % was lower. In both sexes, fat % was lower in diseased rats. Bone mineral content (BMC) and density were higher in rats fed flaxseed oil and lower in diseased rats, additionally; BMC was lower in SDG-supplemented females. The benefit of flaxseed oil on body composition is sex specific but the effect on bone mass is not. Lastly, reduced weight due to early rat kidney disease is not due to loss of lean body mass.
Weiler
H A
HA
School of Dietetics and Human Nutrition, McGill University, Ste. Anne de Bellevue, Que., Canada H9X 3V9. hope.weiler@mcgill.ca
Kovacs
H
H
Nitschmann
E
E
Bankovic-Calic
N
N
Aukema
H
H
Ogborn
M
M
D000818:Animals; D001835:Body Weight; D015519:Bone Density; D002072:Butylene Glycols / Q000008:administration & dosage* / Q000378:metabolism; D003314:Corn Oil / Q000008:administration & dosage; D004041:Dietary Fats / Q000008:administration & dosage / Q000378:metabolism; D005260:Female; D005960:Glucosides / Q000008:administration & dosage* / Q000378:metabolism; D007674:Kidney Diseases / Q000378:metabolism*; D008043:Linseed Oil / Q000008:administration & dosage* / Q000378:metabolism; D008297:Male; D011897:Random Allocation; D051381:Rats; D011919:Rats, Inbred Strains
D002072:Butylene Glycols; D004041:Dietary Fats; D005960:Glucosides; D008043:Linseed Oil; D003314:Corn Oil; C090142:secoisolariciresinol diglucoside