title: Association of neuropeptide Y receptor Y5 polymorphisms with dyslipidemia in Mexican Americans.
abstract: We examined the genetic association of neuropeptide Y receptor Y5 (NPY5R) single nucleotide polymorphisms (SNPs) with measures of the insulin resistance (metabolic) syndrome. We genotyped 10 NPY5R SNPs in 439 Mexican American individuals (age=43.3+/-17.3 years and BMI=30.0+/-6.7 kg/m2) distributed across 27 pedigrees from the San Antonio Family Diabetes Study and performed association analyses using the measured genotype approach as implemented in Sequential Oligogenic Linkage Analysis Routines (SOLAR). Minor alleles for five (rs11100493, rs12501691, P1, rs11100494, rs12512687) of the NPY5R SNPs were found to be significantly (p<0.05) associated with fasting plasma triglyceride concentrations and decreased high-density lipoprotein concentrations. In addition, the minor allele for SNP P2 was significantly associated (p=0.031) with a decreased homeostasis model assessment of beta-cell function (HOMA-%beta). Linkage disequilibrium between SNP pairs indicated one haplotype block of five SNPs (rs11100493, rs12501691, P1, rs11100494, rs12512687) that were highly correlated (r2>0.98). These preliminary results provide evidence for association of SNPs in the NPY5R gene with dyslipidemia (elevated triglyceride concentrations and reduced high-density lipoprotein levels) in our Mexican American population.
authors.affiliation: Division of Diabetes MC 7886, Department of Medicine, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229-3900, USA. richardsond2@uthscsa.edu
authors.forename: Dawn K
authors.initials: DK
authors.lastname: Coletta
authors.forename: Jennifer
authors.initials: J
authors.lastname: Schneider
authors.forename: Michael P
authors.initials: MP
authors.lastname: Stern
authors.forename: John
authors.initials: J
authors.lastname: Blangero
authors.forename: Ralph A
authors.initials: RA
authors.lastname: DeFronzo
authors.forename: Ravindranath
authors.initials: R
authors.lastname: Duggirala
authors.forename: Christopher P
authors.initials: CP
authors.lastname: Jenkinson
mesh_terms: D000328:Adult; D000483:Alleles; D050171:Dyslipidemias / Q000208:ethnology* / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000235:genetics; D017058:Mexican Americans; D008875:Middle Aged; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D017476:Receptors, Neuropeptide Y / Q000235:genetics*
chemical_list: D017476:Receptors, Neuropeptide Y