Modulation of HLA-G and HLA-E expression in human neuronal cells after rabies virus or herpes virus simplex type 1 infections.
Human Leukocyte Antigen (HLA)-G and E are nonclassical human MHC class I molecules. They may promote tolerance leading to virus and tumor immune escape. We recently described that the herpes simplex virus type 1 (HSV-1), a neurotropic virus inducing chronic infection and neuron latency, and rabies virus (RABV), a neuronotropic virus triggering acute neuron infection, up-regulate HLA-G expression in human neurons (NT2-N). Surface expression was only detected after RABV infection. We investigated here whether RABV and HSV-1 up-regulate HLA-E expression in human neuronal precursors (Ntera-2D/1). We found that RABV, not HSV-1, up-regulates HLA-E expression, nevertheless HLA-E could not be detected on the surface of RABV-infected Ntera-2D/1. Altogether these data suggest that HLA-G and not HLA-E could contribute to the immune escape of RABV. In contrast, there was no evidence that these molecules are used by latent HSV-1 infection. Thus, neurotropic viruses that escape the host immune response totally (RABV) or partially (HSV-1) regulate HLA-G expression on human neuronal cells differentially.
Mégret
Françoise
F
Laboratoire de Neuroimmunologie Virale, Institut Pasteur, Paris, France.
Prehaud
Christophe
C
Lafage
Mireille
M
Moreau
Philippe
P
Rouas-Freiss
Nathalie
N
Carosella
Edgardo D
ED
Lafon
Monique
M
D002460:Cell Line; D002462:Cell Membrane / Q000276:immunology; D006680:HLA Antigens / Q000096:biosynthesis / Q000235:genetics*; D059951:HLA-G Antigens; D018259:Herpesvirus 1, Human / Q000276:immunology*; D015395:Histocompatibility Antigens Class I / Q000096:biosynthesis / Q000235:genetics*; D006801:Humans; D009474:Neurons / Q000276:immunology* / Q000378:metabolism / Q000821:virology; D011820:Rabies virus / Q000276:immunology*; D015854:Up-Regulation / Q000276:immunology; D000097625:HLA-E Antigens
D006680:HLA Antigens; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I; D000097625:HLA-E Antigens