Prognostic factors in oocyte donation: an analysis through egg-sharing recipient pairs showing a discordant outcome.
OBJECTIVE
To analyze prognostic factors that are associated with a discordant outcome in egg recipients sharing oocytes from the same donor.


METHODS
Matched case-control single-center study.


METHODS
Private infertility clinic.


METHODS
Four hundred forty-four recipients (222 pairs) sharing oocytes from the same donor and showing a discordant outcome.


METHODS
Controlled ovarian hyperstimulation of egg donors, oocyte donation, intracytoplasmic sperm injection, and ET in egg recipients.


METHODS
Recipient age, obstetric (gravidity, parity) and gynecologic variables (previous uterine surgery, uterine fibroids, uterine malformations, endometriosis, history of tubal infertility), previous oocyte donation cycles, duration of E(2) replacement, received cumulus-oocyte complexes, mature (MII) oocytes, fertilized oocytes, transferred embryos, mean embryo score, transfer difficulty, and semen parameters.


RESULTS
No significant differences were found in the above-mentioned prognostic factors between the study and control groups.


CONCLUSIONS
Recipient- and cycle-related prognostic factors investigated in our study were not associated with a discordant outcome in recipient pairs sharing oocytes from the same donor. Other possible prognostic factors involving oocyte donor heterogeneity, embryo aneuploidy rates, male factor infertility, and endometrial receptivity should be further investigated.
Bodri
Daniel
D
Clínica EUGIN, Barcelona, Spain. dbodri@euvitro.com
Colodron
Marta
M
Vidal
Ricard
R
Galindo
Anna
A
Durban
Mercè
M
Coll
Oriol
O
D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D020964:Embryo Loss / Q000175:diagnosis* / Q000209:etiology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D018587:Oocyte Donation; D009865:Oocytes / Q000637:transplantation; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D014180:Transplantation; D016896:Treatment Outcome