title: Prognostic significance of paraglottic space invasion in T2N0 glottic carcinoma.
abstract: OBJECTIVE
  The purpose of this study was to evaluate the prognostic significance of paraglottic space invasion determined with pretreatment computed tomography (CT) for patients with T2N0 glottic carcinoma treated with radiotherapy (RT).
  
  
  METHODS
  Eighty patients with T2N0 glottic squamous cell carcinomas treated with definitive RT between 1983 and 2002 who had pretreatment CT information available regarding paraglottic space invasion were analyzed. Follow up ranged from 0.14 to 18 years (median, 7.1 years). No patient was lost to follow up.
  
  
  RESULTS
  Five-year outcomes were: local control, 78%; local control with larynx preservation, 80%; relapse-free survival, 71%; and cause-specific survival, 91%. Multivariate analyses of various parameters (including vocal cord mobility, paraglottic space invasion, supraglottic invasion, and subglottic extension) showed that only subglottic extension significantly influenced the probability of cure.
  
  
  CONCLUSIONS
  Paraglottic space invasion is likely associated with increased tumor volume and, by itself, is not necessarily associated with poorer outcome after definitive RT.
authors.affiliation: Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, Florida, USA.
authors.forename: Roi
authors.initials: R
authors.lastname: Dagan
authors.forename: Christopher G
authors.initials: CG
authors.lastname: Morris
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Bennett
authors.forename: Anthony A
authors.initials: AA
authors.lastname: Mancuso
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Amdur
authors.forename: Russell W
authors.initials: RW
authors.lastname: Hinerman
authors.forename: William M
authors.initials: WM
authors.lastname: Mendenhall
mesh_terms: D000704:Analysis of Variance; D019583:Dose Fractionation, Radiation; D005260:Female; D005931:Glottis / Q000473:pathology*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000000981:diagnostic imaging / Q000401:mortality / Q000473:pathology* / Q000532:radiotherapy; D008297:Male; D015999:Multivariate Analysis; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D016019:Survival Analysis; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome