Tumor necrosis factor is critical to control tuberculosis infection.
Tumor necrosis factor (TNF) is critical and non-redundant to control Mycobacterium tuberculosis infection and cannot be replaced by other proinflammatory cytokines. Overproduction of TNF may cause immunopathology, while TNF neutralization reactivates latent and chronic, controlled infection, which is relevant for the use of neutralizing TNF therapies in patients with rheumatoid arthritis.
Jacobs
Muazzam
M
Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
Togbe
Dieudonnée
D
Fremond
Cecile
C
Samarina
Arina
A
Allie
Nasiema
N
Botha
Tania
T
Carlos
Daniela
D
Parida
Shreemanta K
SK
Grivennikov
Sergei
S
Nedospasov
Sergei
S
Monteiro
Analbery
A
Le Bert
Marc
M
Quesniaux
Valerie
V
Ryffel
Bernhard
B
D000818:Animals; D006801:Humans; D009169:Mycobacterium tuberculosis / Q000276:immunology / Q000502:physiology*; D014376:Tuberculosis / Q000276:immunology* / Q000503:physiopathology; D048069:Tumor Necrosis Factors / Q000172:deficiency / Q000276:immunology / Q000502:physiology*
D048069:Tumor Necrosis Factors