title: c-Myb immunoreactivity, protein and mRNA levels significantly increase in the aged hippocampus proper in gerbils.
abstract: Myb genes are a family of transcription factors and have been implicated in the control of the proliferation and differentiation of normal and transformed cells. c-Myb is the best characterized member of the myb family. In the present study, we investigated age-dependent changes of c-myb immunoreactivity, its protein and mRNA level in the hippocampus proper (CA1-3 regions) at various age stages in gerbils. In the postnatal month 1 (PM 1) group, c-myb immunoreactivity was detected in non-pyramidal neurons of the strata oriens and radiatum as well as in pyramidal neurons of the stratum pyramidale. At PM 3, c-myb immunoreactivity and its protein level were similar to those at PM 1. Thereafter, c-myb immunoreactivity and its protein level were increased with time. In the PM 24 group, c-myb immunoreactivity, its protein and mRNA levels were highest. These results suggest that the significant increase of c-myb immunoreactivity, protein and mRNA levels in the aged hippocampus may be associated with neuronal aging.
authors.affiliation: Department of Anatomy and Neurobiology, College of Medicine, Hallym University, Chuncheon, South Korea.
authors.forename: In Koo
authors.initials: IK
authors.lastname: Hwang
authors.forename: Seung Myung
authors.initials: SM
authors.lastname: Moon
authors.forename: Ki-Yeon
authors.initials: KY
authors.lastname: Yoo
authors.forename: Hua
authors.initials: H
authors.lastname: Li
authors.forename: Heum Dai
authors.initials: HD
authors.lastname: Kwon
authors.forename: Hyung Sik
authors.initials: HS
authors.lastname: Hwang
authors.forename: Sun Kil
authors.initials: SK
authors.lastname: Choi
authors.forename: Bong-Hee
authors.initials: BH
authors.lastname: Lee
authors.forename: Jong Dai
authors.initials: JD
authors.lastname: Kim
authors.forename: Moo Ho
authors.initials: MH
authors.lastname: Won
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D015153:Blotting, Western; D020570:Genes, myb / Q000502:physiology*; D005849:Gerbillinae; D006624:Hippocampus / Q000254:growth & development* / Q000378:metabolism*; D007150:Immunohistochemistry; D008297:Male; D020598:Proto-Oncogene Proteins c-myb / Q000096:biosynthesis / Q000378:metabolism*; D017966:Pyramidal Cells / Q000378:metabolism; D012333:RNA, Messenger / Q000096:biosynthesis*; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D020598:Proto-Oncogene Proteins c-myb; D012333:RNA, Messenger