Lung transplantation in the United States: 1990-2005.
The number of lung transplants reported to the OPTN/UNOS Registry has been increasing during the past 15 years. The increase is mainly due to a steady increase in transplants in the 50-64 age group. There is also a trend toward increasing lung transplants for older patients (> 65 yr) since 2001. Among whites, COPD, IPF, CF, alpha1-ATD, and PPH were the top 5 original diseases leading to lung transplantation; while for blacks, sarcoidosis, COPD, and IPF were the major original diseases. Recipients with IPF had significantly lower graft survival rates than COPD patients. One-year graft survival rates increased from 70% in the early 1990s to more than 80% in the most recent 3-year period, but the increase in long-term graft survival has been very limited. The negative effect of previous transplantation on graft survival was only significant within the first post transplant year; in contrast, the negative effect of HLA mismatches is more apparent on long-term graft survival. Acute rejection within the first year had a significant deleterious effect on long-term graft survival.
Cai
Junchao
J
Terasaki Foundation Laboratory, Los Angeles, CA, USA.
Mao
Quanzong
Q
Ozawa
Miyuki
M
Terasaki
Paul I
PI
D000328:Adult; D017677:Age Distribution; D000368:Aged; D005260:Female; D006084:Graft Rejection / Q000453:epidemiology; D006085:Graft Survival; D006801:Humans; D008171:Lung Diseases / Q000145:classification / Q000601:surgery; D016040:Lung Transplantation / Q000502:physiology / Q000706:statistics & numerical data*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D014481:United States; D014850:Waiting Lists