title: Nilvadipine prevents the impairment of spatial memory induced by cerebral ischemia combined with beta-amyloid in rats.
abstract: In the present study, we examined the effects of nilvadipine and amlodipine, both dihydropyridine-derivative calcium antagonists, on the impairment of spatial memory induced by a combination of ischemia and beta-amyloid (Abeta). Nilvadipine (3.2 mg/kg, i.p.) significantly prevented the impairment of spatial memory and neuronal apoptosis in this model. By contrast, amlodipine had no effect on this impairment of spatial memory. These findings suggest that nilvadipine may prevent impairment of spatial memory by inhibiting neuronal apoptosis; this drug might therefore be useful for the prevention of the progression to dementia in Alzheimer's disease (AD).
authors.affiliation: Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan. iwasakik@fukuoka-u.ac.jp
authors.forename: Katsunori
authors.initials: K
authors.lastname: Iwasaki
authors.forename: Nobuaki
authors.initials: N
authors.lastname: Egashira
authors.forename: Yuki
authors.initials: Y
authors.lastname: Takagaki
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Yoshimitsu
authors.forename: Izzettin
authors.initials: I
authors.lastname: Hatip-Al-Khatib
authors.forename: Kenichi
authors.initials: K
authors.lastname: Mishima
authors.forename: Michihiro
authors.initials: M
authors.lastname: Fujiwara
mesh_terms: D016229:Amyloid beta-Peptides / Q000633:toxicity*; D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D002545:Brain Ischemia / Q000503:physiopathology*; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008569:Memory Disorders / Q000188:drug therapy*; D009474:Neurons / Q000187:drug effects; D009543:Nifedipine / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013028:Space Perception / Q000187:drug effects*
chemical_list: D016229:Amyloid beta-Peptides; D002121:Calcium Channel Blockers; C035100:nilvadipine; D009543:Nifedipine