Dietary fiber and risk of colorectal cancer in the Japan collaborative cohort study.
To examine the association of dietary fiber with the risk of colorectal cancer in a population with a high incidence of cancer and a low fiber intake, we analyzed the data from the Japan Collaborative Cohort Study. From 1988 to 1990, 43,115 men and women aged 40 to 79 years completed a questionnaire on dietary and other factors. Intake of dietary fiber was estimated using a food frequency questionnaire. Rate ratios (RR) were computed by fitting proportional hazards models. During the mean follow-up of 7.6 years, 443 colorectal cancer cases were recorded. In all participants, we found a decreasing trend in risk of colorectal cancer with increasing intake of total dietary fiber; the multivariate-adjusted RRs across quartiles were 1.00, 0.96 [95% confidence interval (95% CI), 0.72-1.27], 0.72 (0.53-0.99), and 0.73 (0.51-1.03; P(trend) = 0.028). This trend was exclusively detected for colon cancer: the corresponding RRs were 1.00, 0.90 (95% CI, 0.64-1.26), 0.56 (0.38-0.83), and 0.58 (0.38-0.88; P(trend) = 0.002). The decrease in RRs with increasing intake of dietary fiber was larger in men than in women. No material differences appeared in the strength of associations with the risk between water-soluble and insoluble dietary fiber. For food sources of fiber, bean fiber intake was somewhat inversely correlated with colorectal cancer risk. This prospective study supported potential protective effects of dietary fiber against colorectal cancer, mainly against colon cancer. The role of dietary fiber in the prevention of colorectal cancer seems to remain inconsistent, and further investigations in various populations are warranted. (
Wakai
Kenji
K
Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1-1 Kanokoden, Chikusa-ku, Nagoya 464-8681, Japan. wakai@aichi-cc.jp
Date
Chigusa
C
Fukui
Mitsuru
M
Tamakoshi
Koji
K
Watanabe
Yoshiyuki
Y
Hayakawa
Norihiko
N
Kojima
Masayo
M
Kawado
Miyuki
M
Suzuki
Koji
K
Hashimoto
Shuji
S
Tokudome
Shinkan
S
Ozasa
Kotaro
K
Suzuki
Sadao
S
Toyoshima
Hideaki
H
Ito
Yoshinori
Y
Tamakoshi
Akiko
A
D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D015331:Cohort Studies; D015179:Colorectal Neoplasms / Q000453:epidemiology*; D004043:Dietary Fiber; D005247:Feeding Behavior; D005260:Female; D006801:Humans; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D012306:Risk; D011795:Surveys and Questionnaires