Insights into molecular medicine: development of new diagnostic and prognostic parameters.
Molecular medicine leads us towards an understanding of some diseases at the molecular level. Examples are the analysis of immune complexes and receptor-antireceptor compounds used in clinical medicine. Structural changes of some serum proteins occur in inflammation, neoplasia and autoimmunity. The detection and analysis of such structural modifications may offer a new field for the diagnosis, prognosis and therapy of some diseases. Modern medicine requires new technologies with high sensitivity, specificity and applicability. For the first time in Austria we have combined fluorescence correlation spectroscope (FCS), surface enhanced laser desorption ionisation--time of flight (SELDI-TOF) and the molecular modelling and visualization system according to the computer enhanced programs. Experimental and computational methods are combined in such a way that clinical data can be interpreted by theoretical methods at a molecular level or vice versa, the computational output delivers input for new investigations. One method brings us single results. In view of the spectrum of parameters relevant to clinical entities, multiplexing is a new way of development. Since the technologies are new, the scientifically interested reader should be informed about the matters arising.
Tilz
Gernot P
GP
Clinical Immunology and Jean Dausset Laboratory, Medical University of Graz, Auenbruggerplatz 8, 8036 Graz, Austria. gernot.tilz@meduni-graz.at
Wiltgen
Marco
M
Demel
Ulrike
U
Faschinger
Christian
C
Schmidinger
Hannes
H
Hermetter
Albin
A
D001082:Aqueous Humor / Q000378:metabolism; D001798:Blood Proteins / Q000378:metabolism; D003198:Computer Simulation / Q000639:trends; D039301:Computers, Molecular / Q000639:trends; D019020:Directed Molecular Evolution / Q000639:trends*; D005544:Forecasting; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000639:trends; D008958:Models, Molecular; D015394:Molecular Structure; D011487:Protein Conformation; D046188:Protein Modification, Translational; D012984:Software / Q000639:trends; D013050:Spectrometry, Fluorescence / Q000639:trends; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Q000639:trends
D001798:Blood Proteins