Bone mineral status in children with congenital adrenal hyperplasia.
Congenital adrenal hyperplasia (CAH) is caused by a deficiency in an adrenal enzyme resulting in alterations in cortisol and aldosterone production. Bone status is affected by chronic glucocorticoid therapy and excess androgen exposure in children with CAH. This cross-sectional study enrolled participants with 21-hydroxylase deficiency from a pediatric referral center. Bone mineral density in the participants was normal when compared to age, gender and ethnicity adjusted standards, with respect to chronological age or bone age. Lean body mass was positively correlated with bone mineral content (BMC), independent of fat mass (p < 0.001). There was no significant correlation between glucocorticoid dose or serum androgen levels and skeletal endpoints. In conclusion, lean body mass appears to be an important correlate of BMC in patients with CAH. The normal bone status may be explained by the differential effects of glucocorticoids on growing bone, beneficial androgen effects, or other disease specific factors.
Fleischman
Amy
A
Division of Endocrinology, Children's Hospital Boston, Harvard Medical School, Boston, MA 02115, USA. Amy.fleischman@childrens.harvard.edu
Ringelheim
Julie
J
Feldman
Henry A
HA
Gordon
Catherine M
CM
D000293:Adolescent; D000312:Adrenal Hyperplasia, Congenital / Q000188:drug therapy / Q000503:physiopathology*; D000328:Adult; D000728:Androgens / Q000378:metabolism; D001823:Body Composition / Q000187:drug effects / Q000502:physiology; D015519:Bone Density / Q000187:drug effects / Q000502:physiology*; D001842:Bone and Bones / Q000502:physiology*; D002648:Child; D003430:Cross-Sectional Studies; D005260:Female; D005938:Glucocorticoids / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D008297:Male; D012044:Regression Analysis; D013255:Steroid 21-Hydroxylase / Q000378:metabolism
D000728:Androgens; D005938:Glucocorticoids; D013255:Steroid 21-Hydroxylase