title: Distribution of gastric lymphoid follicles in Helicobacter pylori-associated gastritis.
abstract: OBJECTIVE
  Lymphoid follicles and the satellite lesions (intestinal metaplasia, atrophy and dysplasia) are known as precursor lesions of mucosa associated lymphoid tissue lymphomas in gastritis. Little is known about their prevalence in different distributions and types of Helicobacter pylori-associated gastritis. The aim of the study was to estimate the topographic prevalence of these lesions in gastritis related with Helicobacter pylori and to associate them with the density of bacteria.
  
  
  METHODS
  Histology for the type of gastritis and for lymphoid follicles and Helicobacter pylori density were studied in antrum and/or corpus biopsies taken from 107 consecutive patients with clinical diagnosis of peptic ulcer.
  
  
  RESULTS
  Lymphoid follicles, panmucosal and superficial gastritis were seen in 31 (31.9%), 84 (86.6%) and 13 (13.4%) out of 97 antrum biopsies, respectively. In the corresponding 28 corpus biopsies, these lesions were seen in 8 (28%), 15 (54%), 13 (46%), respectively. Lymphoid follicles were found more in panmucosal than superficial gastritis in the antrum, however in the same ratios in the corpus. In association with lymphoid follicles, Helicobacterpylori was positive in 7 (87%) of 8 corpus biopsies and in all (100%) of 31 antrum biopsies. No relation was observed between lymphoid follicles and Helicobacter pylori density.
  
  
  CONCLUSIONS
  Examination of antrum biopsies rather than corpus biopsies would be sufficient to screen precarcinogenic lymphoid follicles in Helicobacterpylori associated gastritis.
authors.affiliation: hmehmetsokmen@yahoo.com
authors.forename: Mehmet
authors.initials: M
authors.lastname: Sokmen
authors.forename: Damlanur
authors.initials: D
authors.lastname: Sakiz
authors.forename: Nihat
authors.initials: N
authors.lastname: Akbayir
authors.forename: Cetin
authors.initials: C
authors.lastname: Karaca
authors.forename: Ozdal
authors.initials: O
authors.lastname: Ersoy
authors.forename: Canan
authors.initials: C
authors.lastname: Alkim
authors.forename: Huseyin
authors.initials: H
authors.lastname: Demirsoy
mesh_terms: D000328:Adult; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism* / Q000382:microbiology; D005756:Gastritis / Q000378:metabolism* / Q000382:microbiology; D016481:Helicobacter Infections / Q000378:metabolism*; D016480:Helicobacter pylori; D006801:Humans; D007150:Immunohistochemistry; D008221:Lymphoid Tissue / Q000378:metabolism*; D008297:Male; D011446:Prospective Studies