Pyridoxine induces non-specific EEG alterations in infants with therapy resistant seizures.
OBJECTIVE
In infants with frequent therapy resistant seizures (TRS-infants), clinical detection of pyridoxine-dependency (PD) or -responsiveness (PR) occurs by empirical intravenous (IV) pyridoxine administration during recording of the EEG. However, in undiagnosed TRS-infants it is still unclear to what extent EEG alterations by pyridoxine-IV are attributable to PD/PR or to non-specific responses. Before EEG alterations by pyridoxine-IV can be ascribed to PD/PR, these non-specific responses should be excluded first.


METHODS
In 10 TRS-infants under 1 year of age, we determined the EEG effect by pyridoxine-IV on the EEG-recording.


RESULTS
After pyridoxine-IV administration, our data indicate declined (10-15%; p<0.05) EEG-amplitudes and total power (magnitude/frequency-band) at frontal, central and centro-temporal electrodes.


CONCLUSIONS
In TRS-infants, pyridoxine-IV affects EEG-amplitude and -total power in a non-specific way, which does not identify PD/PR.
Teune
L K
LK
Department of Neurology, University Medical Center Groningen, University of Groningen, The Netherlands.
vd Hoeven
J H
JH
Maurits
N M
NM
Bos
A F
AF
Alffenaar
J W C
JW
Reijngoud
D J
DJ
Brouwer
O F
OF
Sival
D A
DA
D004569:Electroencephalography / Q000187:drug effects*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D011736:Pyridoxine / Q000494:pharmacology* / Q000627:therapeutic use; D012640:Seizures / Q000188:drug therapy / Q000503:physiopathology*; D018709:Statistics, Nonparametric; D014803:Vitamin B Complex / Q000494:pharmacology* / Q000627:therapeutic use
D014803:Vitamin B Complex; D011736:Pyridoxine