Insights on pathogenesis of type 2 diabetes from MODY genetics.
Maturity-onset diabetes of the young (MODY) is a type of non-insulin-dependent diabetes mellitus caused by rare autosomal-dominant mutations. MODY genes play key biochemical roles in the pancreatic beta cell; therefore, common variants of MODY genes are excellent candidate genes for type 2 diabetes. We review recent studies that suggest that common MODY gene variation contributes modestly to the heritability of type 2 diabetes.
Weedon
Michael N
MN
Institute of Biomedical & Clinical Sciences, Peninsula College of Medicine & Dentistry, Peninsula Medical School, St. Lukes Campus, Magdalen Road, Exeter EX1 2LU, UK. Michael.Weedon@pms.ac.uk
Frayling
Timothy M
TM
D051792:Basic Helix-Loop-Helix Proteins / Q000235:genetics; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics* / Q000473:pathology*; D005941:Glucokinase / Q000235:genetics; D051536:Hepatocyte Nuclear Factors / Q000235:genetics; D018398:Homeodomain Proteins / Q000235:genetics; D006801:Humans; D009419:Nerve Tissue Proteins / Q000235:genetics; D015534:Trans-Activators / Q000235:genetics
D051792:Basic Helix-Loop-Helix Proteins; D005941:Glucokinase; D051536:Hepatocyte Nuclear Factors; D018398:Homeodomain Proteins; D009419:Nerve Tissue Proteins; D015534:Trans-Activators; C084010:pancreatic and duodenal homeobox 1 protein; C093564:Neurogenic differentiation factor 1