title: Minimum structure requirement of immunomodulatory glycolipids for predominant Th2 cytokine induction and the discovery of non-linear phytosphingosine analogs.
abstract: Analogs of immunomodulatory glycolipid OCH (2) were prepared and minimum structure requirement to exhibit equivalent profiles was disclosed. Analogs bearing non-linear hydrocarbon chain in the phytosphingosine moiety (18, 19) were shown for the first time to possess comparable cytokine inducing profile to 2. Molecular modeling of 2/hCD1d complex based on the crystal structure of alpha-GalCer (1)/hCD1d complex is also described.
authors.affiliation: Biomedical Research Laboratories, Daiichi Asubio Pharma Co., Ltd, Japan.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Toba
authors.forename: Kenji
authors.initials: K
authors.lastname: Murata
authors.forename: Kyoko
authors.initials: K
authors.lastname: Nakanishi
authors.forename: Bitoku
authors.initials: B
authors.lastname: Takahashi
authors.forename: Naohiro
authors.initials: N
authors.lastname: Takemoto
authors.forename: Minako
authors.initials: M
authors.lastname: Akabane
authors.forename: Takashi
authors.initials: T
authors.lastname: Nakatsuka
authors.forename: Seiichi
authors.initials: S
authors.lastname: Imajo
authors.forename: Takashi
authors.initials: T
authors.lastname: Yamamura
authors.forename: Sachiko
authors.initials: S
authors.lastname: Miyake
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Annoura
mesh_terms: D000818:Animals; D016207:Cytokines / Q000378:metabolism*; D006017:Glycolipids / Q000378:metabolism*; D006801:Humans; D007155:Immunologic Factors / Q000378:metabolism*; D015394:Molecular Structure; D013110:Sphingosine / Q000031:analogs & derivatives* / Q000737:chemistry; D018418:Th2 Cells / Q000378:metabolism*
chemical_list: D016207:Cytokines; D006017:Glycolipids; D007155:Immunologic Factors; C012491:phytosphingosine; D013110:Sphingosine