Arrested replication fork processing: interplay between checkpoints and recombination.
The arrest of DNA replication by DNA damage, nucleotide depletion, DNA-protein complexes or following clashes between transcription and replication factors all have the capacity to promote genome instability. In this review, we discuss how DNA replication is regulated by the checkpoint pathways that stabilise arrested replication forks and the recombination factors that process specific DNA structures resulting from fork arrest. We examine what is known about the interplay between the checkpoints and the recombination apparatus and review the evidence for a recombination-based fork restart pathway in eukaryotes.
Lambert
Sarah
S
Institut Curie-CNRS UMR 2027, Batiment 110, Centre Universitaire, 91405 Orsay, Cedex, France. sarah.lambert@curie.u-psud.fr
Froget
Benoît
B
Carr
Antony M
AM
D000818:Animals; D018797:Cell Cycle Proteins / Q000378:metabolism*; D004249:DNA Damage; D004260:DNA Repair; D004261:DNA Replication; D006801:Humans; D011995:Recombination, Genetic; D016196:S Phase; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism
D018797:Cell Cycle Proteins