title: Aerosol and subcutaneous measles vaccine: measles antibody responses 6 years after re-vaccination.
abstract: There are no large-scale data on the long-term persistence of measles antibody after vaccination by the aerosol route. We therefore followed-up South African schoolchildren 6 years after their re-vaccination with Edmonston-Zagreb (EZ) and Schwarz (SW) measles vaccine given by aerosol and subcutaneous routes. Measles antibody levels and the proportion of children who were seropositive at year 6 remained significantly higher in the Edmonston-Zagreb aerosol group compared to the groups that received Schwarz or Edmonston-Zagreb vaccine subcutaneously. Measles re-vaccination by aerosol evokes a stronger and much longer lasting antibody response than injected vaccine and should thus provide more durable protection against measles.
authors.affiliation: Unit for Clinical and Biomedical TB Research, Medical Research Council, 491 Ridge Road, Overport, Durban 4001, South Africa. dilraja@mrc.ac.za
authors.forename: Athmanundh
authors.initials: A
authors.lastname: Dilraj
authors.forename: Reshma
authors.initials: R
authors.lastname: Sukhoo
authors.forename: Felicity T
authors.initials: FT
authors.lastname: Cutts
authors.forename: John V
authors.initials: JV
authors.lastname: Bennett
mesh_terms: D000293:Adolescent; D000336:Aerosols; D000914:Antibodies, Viral / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007279:Injections, Subcutaneous; D008297:Male; D008457:Measles / Q000276:immunology / Q000517:prevention & control*; D008458:Measles Vaccine / Q000008:administration & dosage* / Q000276:immunology*; D008459:Measles virus / Q000276:immunology*; D013019:South Africa; D013997:Time Factors
chemical_list: D000336:Aerosols; D000914:Antibodies, Viral; D008458:Measles Vaccine