title: What is the best adjuvant treatment for very young patients with medulloblastoma?
abstract: The standard treatment for medulloblastoma is surgery followed by adjuvant chemotherapy and external beam radiotherapy to the craniospinal axis and posterior fossa. However, in very young children, craniospinal irradiation has a more significant detrimental effect in terms of neurocognitive function and growth. This article reviews the different strategies used for very young patients with medulloblastoma.
authors.affiliation: Ohio State University Medical Center, Department of Radiation Medicine, Arthur G James Cancer Hospital, Columbus, OH 43210, USA. james.clarke@osumc.edu
authors.forename: James W
authors.initials: JW
authors.lastname: Clarke
authors.forename: Mersiha
authors.initials: M
authors.lastname: Hadziahmetovic
authors.forename: Katherine
authors.initials: K
authors.lastname: Tzou
authors.forename: Ching C
authors.initials: CC
authors.lastname: Lau
authors.forename: Arnold C
authors.initials: AC
authors.lastname: Paulino
authors.forename: John C
authors.initials: JC
authors.lastname: Grecula
authors.forename: Joseph F
authors.initials: JF
authors.lastname: Montebello
authors.forename: Nina A
authors.initials: NA
authors.lastname: Mayr
authors.forename: Simon S
authors.initials: SS
authors.lastname: Lo
mesh_terms: D001932:Brain Neoplasms / Q000628:therapy*; D017024:Chemotherapy, Adjuvant / Q000379:methods*; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008527:Medulloblastoma / Q000628:therapy*; D018714:Radiotherapy, Adjuvant / Q000379:methods*