[Cytoprotective properties of 3-oxy-6-methyl-2-ethylpyridine succinate in cell cultures].
Tests on calf coronary vessel cells (CVC) cultures showed that 3-oxi-6-methyl-2-ethylpiridine succinate (OMEPS) in dozes within 5.0-10.0 microg/ml did not decrease proliferation index, monolayer development, and viability factor. OMEPS also did not increase cytotoxicity index and did not change cytomorphological characteristics of the culture. In a concentration of 100 microg/ml, OMEPS exhibited some cytotoxyc properties, but to a lower degree compared to the reference antiarrhythmic drug moricisine (1.0-20.0 microg/ml). However, OMEPS (2.5 microg/ml) reduced the cytotoxicity moricisine introduced into CVC culture in a doze of 1.0 microg/ml.
Balashov
V P
VP
D'iakonov
L P
LP
Kolesnikova
S G
SG
Markelova
I A
IA
D000818:Animals; D002417:Cattle; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D003331:Coronary Vessels / Q000166:cytology* / Q000187:drug effects*; D019610:Cytoprotection; D010640:Phenothiazines / Q000037:antagonists & inhibitors / Q000633:toxicity; D010847:Picolines / Q000494:pharmacology*; D020011:Protective Agents / Q000494:pharmacology; D013386:Succinates / Q000494:pharmacology*
C520396:3-hydroxy-6-methyl-2-ethylpyridine succinate; D010640:Phenothiazines; D010847:Picolines; D020011:Protective Agents; D013386:Succinates; C046818:ethacizine