[Oxytetracycline--mechanism of action and application in skin diseases].
Oxytetracycline is a bacteriostatic antibiotic. Newly discovered, additional mechanisms of action include antioxidant, antiinflammatory and immynosupresive activity of oxytetracycline and other tetracyclines. These activities were the basis for developing therapy regimens with oxytetracycline in subantimicrobial doses. Due to its significant efficacy, limited adverse effects and low therapy costs, oxytetracycline at the dose of 500 mg per day is presently considered as therapy of choice in papulopustulous acne. Rosacea and perioral dermatitis are other indications. Topical oxytetracycline shows significant efficacy in primary and secondary skin infections with inflammatory reaction.
Olszewska
Małgorzata
M
Katedry i Kliniki Dermatologicznej Akademii Medycznej w Warszawie. malgorzataolszewska@yahoo.com
D000152:Acne Vulgaris / Q000188:drug therapy* / Q000382:microbiology; D000284:Administration, Oral; D000287:Administration, Topical; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000627:therapeutic use*; D003879:Dermatologic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D010118:Oxytetracycline / Q000009:adverse effects / Q000191:economics / Q000627:therapeutic use*; D012393:Rosacea / Q000188:drug therapy*
D000900:Anti-Bacterial Agents; D003879:Dermatologic Agents; D010118:Oxytetracycline