title: Orbital metastasis as a rare form of clinical presentation of non-small cell lung cancer.
abstract: Approximately 11 million new cases of cancer are diagnosed worldwide each year; one in eight is a lung cancer. More than one million people die of lung cancer each year, and non-small cell lung cancer accounts for approximately 80% of all cases of lung cancer. The incidence of primary tumors that metastasize to the orbit is approximately 7%. In 19% of the cases, there is no history of cancer when the patient presents with ophthalmic symptoms, and in 10%, the primary site remains obscure despite intensive systemic evaluation. We report a rare form of clinical presentation of non-small cell lung cancer in which symptoms caused by orbital metastases were the first manifestations.
authors.affiliation: Department of Medical Oncology, Portuguese Institute of Oncology, Oporto, Portugal. joanamacedo@hotmail.com
authors.forename: Joana Espiga
authors.initials: JE
authors.lastname: Macedo
authors.forename: Manuela
authors.initials: M
authors.lastname: Machado
authors.forename: António
authors.initials: A
authors.lastname: Araújo
authors.forename: Vítor
authors.initials: V
authors.lastname: Angélico
authors.forename: José M
authors.initials: JM
authors.lastname: Lopes
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000188:drug therapy / Q000556:secondary*; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D016190:Carboplatin / Q000627:therapeutic use; D002289:Carcinoma, Non-Small-Cell Lung / Q000175:diagnosis / Q000188:drug therapy / Q000556:secondary; D017809:Fatal Outcome; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D009918:Orbital Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000556:secondary*
chemical_list: D000970:Antineoplastic Agents; D016190:Carboplatin