[Primary mediastinal seminoma. Report of three cases].
BACKGROUND
Primary mediastinal seminomas (PMS) are rare tumors that are morphologically similar to their testicular counterparts but may have different biologic behavior due to their particular anatomical location.


OBJECTIVE
New cases report of PMS CASES: Three new cases of primary mediastinal seminoma are presented. The patients were men aged of 16, 33 and 47 years. Their clinical symptoms included cough, dyspnea, chest pain and superior vena cava syndrome. None of the patients had a previous history of testicular neoplasm or tumor elsewhere. Mediastinoscopic biopsy was performed and histological examination results revealed a seminoma. Immunohistochemical showed membranous staining with placental alkaline phosphatase in the three cases. Chemotherapy has largely replaced surgical resection and radiotherapy as the initial treatment in patients with mediastinal seminoma.
Abid
Leïla
L
Service d'Anatomie et de Cytologie Pathologiques, Hôpital Abderrahman-Mami - 2080 Ariana.
Ayadi-Kaddour
Aïda
A
Braham
Emna
E
Smati
Belhassen
B
Ismail
Olfa
O
Kilani
Tarek
T
El Mezni
Faouzi
F
D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001706:Biopsy; D003131:Combined Modality Therapy; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008479:Mediastinal Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy; D008482:Mediastinum / Q000473:pathology; D008875:Middle Aged; D013902:Radiography, Thoracic; D011879:Radiotherapy Dosage; D018239:Seminoma / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome