title: Proteomics in neurosciences.
abstract: This review provides an outline of the most important proteomic applications in the study of neurodegenerative disorders including Alzheimer's (AD), Parkinson's (PD), Huntington's (HD), and prion diseases, and also discusses advances in cancer and addiction. One of the scopes is to illustrate the potential of proteomics in the biomarkers discovery of these diseases. Finally, this article comments the advantages and drawbacks of the most commonly used techniques and methods for samples preparation.
authors.affiliation: Faculty of Chemistry and Regional Laboratory, Jagiellonian University, Krakow, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Drabik
authors.forename: Anna
authors.initials: A
authors.lastname: Bierczynska-Krzysik
authors.forename: Anna
authors.initials: A
authors.lastname: Bodzon-Kulakowska
authors.forename: Piotr
authors.initials: P
authors.lastname: Suder
authors.forename: Jolanta
authors.initials: J
authors.lastname: Kotlinska
authors.forename: Jerzy
authors.initials: J
authors.lastname: Silberring
mesh_terms: D015415:Biomarkers / Q000032:analysis; D003936:Diagnosis, Computer-Assisted / Q000379:methods; D020869:Gene Expression Profiling / Q000379:methods*; D006801:Humans; D013058:Mass Spectrometry / Q000379:methods*; D019636:Neurodegenerative Diseases / Q000175:diagnosis* / Q000378:metabolism*; D009488:Neurosciences / Q000379:methods*; D010449:Peptide Mapping / Q000379:methods; D020543:Proteome / Q000032:analysis*; D040901:Proteomics / Q000379:methods*; D013048:Specimen Handling / Q000379:methods
chemical_list: D015415:Biomarkers; D020543:Proteome