title: Philadelphia variant, t(5;9;22)(q13;q34;q11), in a case with chronic myeloid leukemia.
abstract: In this paper we report on a case of chronic myeloid leukemia (CML) with a Philadelphia variant involving chromosome 5 as a second change of the standard Philadelphia chromosome (Ph). Molecular analysis found a fusion gene BCR-ABL with participation of exons b3 and a2, respectively (b3a2). The molecular variant of the fusion gene BCR/ ABL or the rare involvement of chromosome 5 could possibly explain the mild course of the disease.
authors.affiliation: National Centre of Haematology and Transfusiology, Sofia, Bulgaria.
authors.forename: G
authors.initials: G
authors.lastname: Balatzenko
authors.forename: J
authors.initials: J
authors.lastname: Grudeva-Popova
authors.forename: T
authors.initials: T
authors.lastname: Krustev
authors.forename: D
authors.initials: D
authors.lastname: Marichkov
authors.forename: M
authors.initials: M
authors.lastname: Stefanova