title: Lupoid sclerosis: what is the role of antiphospholipid antibodies?
abstract: A multiple sclerosis-like syndrome, also called lupoid sclerosis for having some lupus characteristics, has been described in a few reports. Recently, antiphospholipid antibodies have been demonstrated in patients with this syndrome, suggesting that they can participate in the etiopathogenic process, which can have therapeutic implications. We report the case of a patient previously diagnosed with multiple sclerosis who later presented with ANA positivity and antiphospholipid antibodies, livedo reticularis, and deep venous thrombosis, leading her to be characterized as having lupoid sclerosis. The patient was anticoagulated. Antiphospholipid antibodies may be involved in the pathogenesis of lupoid sclerosis.
authors.affiliation: Serviço de Reumatologia do Hospital Santa Izabel (HSI), Salvador, Bahia, Brazil.
authors.forename: Isabella
authors.initials: I
authors.lastname: Lima
authors.forename: Ailton
authors.initials: A
authors.lastname: Melo
authors.forename: Ivar Viana
authors.initials: IV
authors.lastname: Brandi
authors.forename: Olívia
authors.initials: O
authors.lastname: Costa
authors.forename: Mittermayer
authors.initials: M
authors.lastname: Santiago
mesh_terms: D000328:Adult; D000974:Antibodies, Antinuclear / Q000097:blood; D017152:Antibodies, Antiphospholipid / Q000097:blood*; D016736:Antiphospholipid Syndrome / Q000150:complications / Q000276:immunology*; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000150:complications / Q000276:immunology; D009103:Multiple Sclerosis / Q000150:complications / Q000276:immunology*
chemical_list: D000974:Antibodies, Antinuclear; D017152:Antibodies, Antiphospholipid