[The effect of MTHFR polymorphisms, pregnancy and first intercourse on cervical cancer in a population from the Northeastern Mexico].
OBJECTIVE
To investigate the possible association among MTHFR polymorfhisms, environmental factors and cervical cancer (CC) in the Mexican population.


METHODS
Seventy patients with CC and 89 control women were questioned about clinical data and their 677 and 1298 genotypes of MTHFR gene were analized.


RESULTS
Multipregnancies (0-2 vs. > or = 3, OR 2.1), an early age of first intercourse (IVS) (17 < or = vs. > or = 18 years, OR 4.3) or both factors (OR 3.5) were significantly associated with CC. MTHFR 677, 1298 polymorphisms and their combinations were not different between cases and controls. However, a significant association between pregnancies, IVS and MTHFR polymorphisms (presence of 1298C allele or 677TT genotype) was observed. The 1298C allele plus multipregnancies and IVS < or = 17 years, or both factors, increased 4.3, 5.3, and 11.8 times the risk for CC, respectively, while 677TT genotype changed the risk 2.0, 1.9, and 4.2 times, respectively.


CONCLUSIONS
The 1298C allele increases the risk of CC strongly in women with multipregnancies and early age of IVS, while 677TT genotype has a lower risk without becoming a protection factor.
Delgado-Enciso
Iván
I
Departamento de Bioquímica de la Facultad de Medicina, Universidad Autónoma de Nuevo León.
Martínez-Garza
Sandra G
SG
Rojas-Martínez
Augusto
A
Espinoza-Gómez
Francisco
F
Canseco-Avila
Luis M
LM
Vidal-Gutiérrez
Oscar
O
Garza-Leal
José G
JG
Barboza-Quintana
Oralia
O
Flores-Gutiérrez
Juan P
JP
Barrera-Saldaña
Hugo A
HA
Ortiz-López
Rocío
R
D000328:Adult; D000367:Age Factors; D000368:Aged; D003075:Coitus; D005260:Female; D006801:Humans; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D008800:Mexico; D008875:Middle Aged; D010298:Parity; D011110:Polymorphism, Genetic; D011247:Pregnancy; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology* / Q000235:genetics*
D042965:Methylenetetrahydrofolate Reductase (NADPH2)