Resting energy expenditure and body mass changes in women during adjuvant chemotherapy for breast cancer.
Weight gain is a commonly reported side effect of adjuvant chemotherapy. A change in resting energy expenditure during treatment has been a suggested mechanism for weight gain. We prospectively measured resting energy expenditure, weight change, and body composition (dual-energy x-ray absorptiometry) in 10 women undergoing adjuvant chemotherapy for breast cancer. There was no change in resting energy expenditure across cycles of chemotherapy (P =.78) or from baseline to the end of treatment (1,189.68 +/- 80.27 vs 1,205.76 +/- 56.71 kcal/d; P =.74). Overall, participants did not gain weight across treatment. However, there was an overall trend toward weight gain (66.3 +/- 5.1 vs 68.2 +/- 5.0 kg; P =.09), and participants did show an increase in total fat mass (24.2 +/- 3.8 vs 26.5 +/- 3.2 kg; P =.04), whereas muscle mass remained the same. Although no change in resting energy expenditure was seen, the observed increase in total fat mass is consistent with a decrease in physical activity level commonly reported with adjuvant chemotherapy treatment of breast cancer, and these body composition changes may have important health implications for survivors.
Campbell
K L
KL
Allen McGavin Sports Medicine Centre, School of Human Kinetics, University of British Columbia, Vancouver, British Columbia, Canada.
Lane
K
K
Martin
A D
AD
Gelmon
K A
KA
McKenzie
D C
DC
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000704:Analysis of Variance; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D001481:Basal Metabolism / Q000187:drug effects; D001823:Body Composition / Q000187:drug effects; D015992:Body Mass Index; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D017024:Chemotherapy, Adjuvant / Q000009:adverse effects; D004734:Energy Metabolism / Q000187:drug effects*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015412:Mastectomy, Segmental; D008875:Middle Aged; D009367:Neoplasm Staging; D009859:Oncology Nursing / Q000379:methods; D011336:Probability; D011446:Prospective Studies; D012307:Risk Factors; D012494:Sampling Studies; D015996:Survival Rate; D016896:Treatment Outcome; D015430:Weight Gain / Q000187:drug effects