title: Effect of hyperthermia on experimental acute pancreatitis.
abstract: BACKGROUND
  [corrected] Recent studies indicate that hyperthermia can change inflammatory mechanisms and protect experimental animals from deleterious effects of secretagogue-induced acute pancreatitis
  
  
  OBJECTIVE
  To evaluate the effects of hyperthermia post-treatment on cerulein-induced acute pancreatitis in rats
  
  
  METHODS
  Twenty animals were divided in two groups: group I (n = 10), rats with cerulein-induced acute pancreatitis undergone hyperthermia, and group II (n = 10), animals with cerulein-induced acute pancreatitis that were kept normothermic. In all groups, amylase serum levels, histologic damage, vascular permeability and pancreatic water content were assessed. Acute pancreatitis was induced by administration of two cerulein injections (20 mcg/kg). A single dose of Evans' blue dye was administered along with the second dose of cerulein. All animals also received a subcutaneous injection of saline solution. After this process, animals undergone hyperthermia were heated in a cage with two 100 W lamps. Body temperature was increased to 39.5 degrees C and maintained at that level for 45 minutes. Normothermia rats were kept at room temperature in a second cage
  
  
  RESULTS
  Control animals had typical edema, serum amylase activity and morphologic changes of this acute pancreatitis model. Hyperthermia post-treatment ameliorated the pancreatic edema, whereas the histologic damage and the serum amylase level remained unchanged
  
  
  CONCLUSIONS
  The findings suggest a beneficial effect of the thermal stress on inflammatory edema in experimental acute pancreatitis.
authors.affiliation: Department of Gastroenterology, Medical School, University of São Paulo, São Paulo, SP, Brazil. josluizalmeida@yahoo.com.br
authors.forename: José Luiz Jesus
authors.initials: JL
authors.lastname: de Almeida
authors.forename: José
authors.initials: J
authors.lastname: Jukemura
authors.forename: Sandra Nassa
authors.initials: SN
authors.lastname: Sampietre
authors.forename: Rosely Antunes
authors.initials: RA
authors.lastname: Patzina
authors.forename: José Eduardo Monteiro
authors.initials: JE
authors.lastname: da Cunha
authors.forename: Marcel Cerqueira César
authors.initials: MC
authors.lastname: Machado
mesh_terms: D000208:Acute Disease; D000681:Amylases / Q000097:blood; D000818:Animals; D001831:Body Temperature / Q000502:physiology; D002108:Ceruletide; D004195:Disease Models, Animal; D004487:Edema / Q000517:prevention & control / Q000628:therapy*; D006979:Hyperthermia, Induced; D018836:Inflammation Mediators / Q000032:analysis; D053583:Interleukin-1beta / Q000032:analysis; D015850:Interleukin-6 / Q000032:analysis; D010195:Pancreatitis / Q000139:chemically induced / Q000628:therapy*; D051381:Rats; D017208:Rats, Wistar; D018709:Statistics, Nonparametric; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
chemical_list: D018836:Inflammation Mediators; D053583:Interleukin-1beta; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D002108:Ceruletide; D000681:Amylases