Neural-tube-derived neuroepithelial stem cells: a new transplant resource for Parkinson's disease.
To assess the feasibility of using neuroepithelial stem cells as a transplant source for Parkinson's disease, neuroepithelial cells were harvested from the neural tube, cultured and stereotactically transplanted into the striatum of a rat model of Parkinson's disease. In culture, neuroepithelial cells generated abundant neurospheres and differentiated into both neurons and glia. After transplantation, tyrosine-hydroxylase-positive cells were detected in the graft. Furthermore, an apomorphine-induced rotation test showed that the implanted cells successfully promoted functional recovery in animals that underwent this transplantation procedure. Our results demonstrate that neuroepithelial cells may be a new source of donor material for Parkinson's disease.
Sun
Jinhao
J
Institute of Anatomy and Histology and Embryology, School of Medicine, Shandong University, Jinan, PR China.
Gao
Yingmao
Y
Yang
Lin
L
Li
Zhenhua
Z
Lu
Gang
G
Yew
David
D
D000818:Animals; D001522:Behavior, Animal; D002454:Cell Differentiation; D002470:Cell Survival; D003342:Corpus Striatum / Q000601:surgery*; D053595:Embryonic Stem Cells / Q000166:cytology / Q000637:transplantation*; D005260:Female; D006085:Graft Survival; D046569:Neuroepithelial Cells / Q000166:cytology / Q000637:transplantation*; D016627:Oxidopamine; D020734:Parkinsonian Disorders / Q000601:surgery*; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D013116:Spinal Cord / Q000166:cytology / Q000196:embryology; D013565:Sympatholytics
D013565:Sympatholytics; D016627:Oxidopamine