Effect of mesenchymal stem cell transplantation on cognitive functions in rats with ischemic stroke.
The effect of intravenous transplantation of mesenchymal stem cells on the recovery of cognitive functions was studied in Wistar-Kyoto rats after brain stroke induced by occlusion of the middle cerebral artery in the left hemisphere. Analysis 2 and 5 weeks after stroke showed that transplantation of mesenchymal stem cells 3 days after middle cerebral artery occlusion reduced the area of cerebral injury, preserved cognitive functions, and decreased mortality in experimental animals.
Sokolova
I B
IB
Trans-Tekhnologiya Company, Russian Academy of Medical Sciences, St. Petersburg.
Fedotova
O R
OR
Zin'kova
N N
NN
Kruglyakov
P V
PV
Polyntsev
D G
DG
D000818:Animals; D002545:Brain Ischemia / Q000503:physiopathology* / Q000523:psychology / Q000628:therapy*; D003071:Cognition / Q000502:physiology*; D004195:Disease Models, Animal; D005434:Flow Cytometry; D008297:Male; D018782:Maze Learning; D045164:Mesenchymal Stem Cell Transplantation; D020768:Middle Cerebral Artery / Q000601:surgery; D051381:Rats; D011921:Rats, Inbred WKY; D012016:Reference Values; D013550:Swimming