Induction of human adiponectin gene transcription by telmisartan, angiotensin receptor blocker, independently on PPAR-gamma activation.
Adiponectin, an adipose tissue-specific plasma protein, has been shown to ameliorate insulin resistance and inhibit the process of atherosclerosis. Recently, several reports have stated that angiotensin type 1 receptor blockers (ARBs), increase adiponectin plasma level, and ameliorate insulin resistance. Telmisartan, a subclass of ARBs, has been shown to be a partial agonist of the peroxisome proliferator-activated receptor (PPAR)-gamma, and to increase the plasma adiponectin level. However, the transcriptional regulation of the human adiponectin gene by telmisartan has not been determined yet. To elucidate the effect of telmisartan on adiponectin, the stimulatory regulation of human adiponectin gene by telmisartan was investigated in 3T3-L1 adipocytes, utilizing adenovirus-mediated luciferase reporter gene-transferring technique. This study indicates that telmisartan may stimulate adiponectin transcription independent of PPAR-gamma.
Moriuchi
Akie
A
Department of Endocrinology and Metabolism, Unit of Translational Medicine, Graduate School of Biomedical Science, Nagasaki University, and Hospital of Medicine and Dentistry, Nagasaki, Japan.
Yamasaki
Hironori
H
Shimamura
Mika
M
Kita
Atsushi
A
Kuwahara
Hironaga
H
Fujishima
Keiichiro
K
Satoh
Tsuyoshi
T
Fukushima
Keiko
K
Fukushima
Tetsuya
T
Hayakawa
Takao
T
Mizuguchi
Hiroyuki
H
Nagayama
Yuji
Y
Abiru
Norio
N
Kawasaki
Eiji
E
Eguchi
Katsumi
K
D041721:3T3-L1 Cells; D017667:Adipocytes / Q000187:drug effects / Q000378:metabolism*; D052242:Adiponectin / Q000235:genetics / Q000378:metabolism*; D047228:Angiotensin II Type 1 Receptor Blockers / Q000008:administration & dosage*; D000818:Animals; D001562:Benzimidazoles / Q000008:administration & dosage*; D001565:Benzoates / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D051379:Mice; D047495:PPAR gamma / Q000378:metabolism*; D000077333:Telmisartan; D015533:Transcriptional Activation / Q000187:drug effects / Q000502:physiology*
D052242:Adiponectin; D047228:Angiotensin II Type 1 Receptor Blockers; D001562:Benzimidazoles; D001565:Benzoates; D047495:PPAR gamma; D000077333:Telmisartan