title: [Association of aldosterone synthase gene -344 T/C polymorphism with early renal damage in Han nationality with essential hypertension].
abstract: OBJECTIVE
  To investigate whether the -344T/C polymorphism of aldosterone synthase gene is associated with early renal damage in Han nationality with essential hypertension in Shandong province.
  
  
  METHODS
  Plasma aldosterone concentration and urinary albumin excretion were measured with radioimmunoassays in 225 patients with essential hypertension, and hypertensives were classified as hypertension with normal albuminuria or hypertension with microalbuminuria according to urinary albumin excretion during 24 hours. -344T/C polymorphism of aldosterone synthase gene was determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in controls and hypertensives.
  
  
  RESULTS
  No significant differences were found in genotype distribution among groups of control, primary hypertension with normal albuminuria and hypertension with microalbuminuria. The C allele frequency in hypertension with microal buminuria group was significantly higher than that in control and hypertension with normal albuminuria group (P < 0.05). In hypertensive patients, plasma aldosterone concentration and urinary albumin excretion of TC+CC genotypes were significantly higher than that of TT genotype ( P< 0.05).
  
  
  CONCLUSIONS
  These results suggest that -344T/C polymorphism of aldosterone synthase gene may be associated with early renal damage in Han nationality with essential hypertension, C allele may be a genetic factor susceptible to renal damage in hypertensives.
authors.affiliation: Department of Cardiology, Affiliated Yuhuangding Hospital, Qingdao University, Yantai, Shandong, 264000 PR China. sunxj315@163.com
authors.forename: Xiao-jian
authors.initials: XJ
authors.lastname: Sun
authors.forename: Shao-rong
authors.initials: SR
authors.lastname: Liu
authors.forename: Chuan-huan
authors.initials: CH
authors.lastname: Zhang
authors.forename: Guo-hui
authors.initials: GH
authors.lastname: Yuan
authors.forename: Hong-ying
authors.initials: HY
authors.lastname: Chen
authors.forename: Xiao-fei
authors.initials: XF
authors.lastname: Hou
mesh_terms: D000328:Adult; D000418:Albumins / Q000378:metabolism; D000419:Albuminuria / Q000097:blood / Q000235:genetics; D000450:Aldosterone / Q000097:blood; D044466:Asian People / Q000235:genetics; D002681:China; D019405:Cytochrome P-450 CYP11B2 / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000150:complications*; D007674:Kidney Diseases / Q000150:complications / Q000208:ethnology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011863:Radioimmunoassay
chemical_list: D000418:Albumins; D000450:Aldosterone; D019405:Cytochrome P-450 CYP11B2