title: Synthesis and conformational analysis of an alpha-D-mannopyranosyl-(1-->2)-alpha-D-mannopyranosyl-(1-->6)-alpha-D-mannopyranose mimic.
abstract: A mimic of a (1-->2),(1-->6)-mannotrioside was synthesized by replacing the central mannose unit with an enantiomerically pure, conformationally stable trans-diaxial cyclohexanediol. The three-dimensional structure of the molecule was investigated by NMR spectroscopy supported by molecular modelling and was compared to the known features of the natural mannotrioside.
authors.affiliation: Centro de Investigaciones Biológicas, Departamento de Estructura y Functión de Proteínas, CSIC, c/Ramiro de Maeztu 9, 28040 Madrid, Spain.
authors.forename: Silvia
authors.initials: S
authors.lastname: Mari
authors.forename: Inmaculada
authors.initials: I
authors.lastname: Sánchez-Medina
authors.forename: Pierangelo
authors.initials: P
authors.lastname: Mereghetti
authors.forename: Laura
authors.initials: L
authors.lastname: Belvisi
authors.forename: Jesus
authors.initials: J
authors.lastname: Jiménez-Barbero
authors.forename: Anna
authors.initials: A
authors.lastname: Bernardi
mesh_terms: D002151:Calorimetry; D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008362:Mannosides / Q000737:chemistry; D008958:Models, Molecular; D008969:Molecular Sequence Data; D014312:Trisaccharides / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D007202:Indicators and Reagents; D008362:Mannosides; D014312:Trisaccharides