title: Is second-line enuretic alarm therapy after unsuccessful pharmacotherapy superior to first-line therapy in the treatment of monosymptomatic nocturnal enuresis?
abstract: BACKGROUND
  We aimed at comparing the success rates of primary enuretic alarm therapy with those of secondary alarm therapy after failed pharmacotherapy in the treatment of monosymptomatic nocturnal enuresis (MNE).
  
  
  METHODS
  We randomly applied enuretic alarm therapy in 35 MNE patients (group 1) and desmopressin therapy in 49 MNE patients (group 2). The success and rebound rates after 3 and 6 months were determined. We also applied enuretic alarm therapy as a secondary treatment in 19 group 2 patients with complete rebound after 6 months (group 3). The success rates of patients who have received primary and secondary enuretic alarm therapy were compared.
  
  
  RESULTS
  The success rates for groups 1 and 2 were 82.65 and 81.63%, respectively (p = 0.885), at 3 months and 54.28 and 26.53%, respectively (p = 0.007), at 6 months. The success rates in group 3 were 84.21 and 52.63%, respectively, at 3 and 6 months. When these success rates were compared between groups 1 and 3, no statistically significant difference was found (p = 1.000).
  
  
  CONCLUSIONS
  Prior pharmacotherapy did not increase success rates of alarm therapy in our MNE patients.
authors.affiliation: Department of Urology, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey. tuyguncan@yahoo.com
authors.forename: Can
authors.initials: C
authors.lastname: Tuygun
authors.forename: Muzaffer
authors.initials: M
authors.lastname: Eroglu
authors.forename: Hasan
authors.initials: H
authors.lastname: Bakirtas
authors.forename: Adnan
authors.initials: A
authors.lastname: Gucuk
authors.forename: Kursad
authors.initials: K
authors.lastname: Zengin
authors.forename: Abdurrahim
authors.initials: A
authors.lastname: Imamoglu
mesh_terms: D000293:Adolescent; D050034:Antidiuretic Agents / Q000627:therapeutic use; D002648:Child; D003894:Deamino Arginine Vasopressin / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D053206:Nocturnal Enuresis / Q000188:drug therapy / Q000628:therapy*; D013812:Therapeutics / Q000295:instrumentation; D017211:Treatment Failure
chemical_list: D050034:Antidiuretic Agents; D003894:Deamino Arginine Vasopressin