title: The relationship between seroatopy and symptoms of either allergic rhinitis or asthma.
abstract: BACKGROUND
  Epidemiologic data on allergic rhinitis and asthma are frequently based on self-reported symptoms.
  
  
  OBJECTIVE
  This cross-sectional study examined the relationship between self-reported symptoms and histories of allergic rhinitis or asthma and a marker of allergic sensitization, allergen-specific IgE.
  
  
  METHODS
  We surveyed 702 pregnant women in Michigan. Blood samples were analyzed for specific IgE to 9 allergens: dust mites (Dermatophagoides farinae and Dermatophagoides pteronyssinus), cat, dog, cockroach, ragweed, timothy grass, egg, and Alternaria alternata. Seratopy was defined as a specific IgE greater than or equal to 0.35 kU/L to any allergen.
  
  
  RESULTS
  Seroatopy was found in 66.7% of those with hay fever symptoms, 68.3% with a physician's diagnosis of asthma, and 72.1% of those with both conditions. These results differed significantly from asymptomatic subjects, where 49.8% of patients without hay fever and 50.4% without asthma were seroatopic. Race and education did not modify the relationships. Symptoms related to specific exposures were modest predictors of positive specific IgE to related allergens (positive predictive values from 26.5% to 50.3%).
  
  
  CONCLUSIONS
  Self-reported symptoms of allergic rhinitis or asthma were significantly associated with allergic sensitization, but the odds ratios were of relatively low magnitude for this historical information to be considered evidence of current allergic sensitization. A 66% to 68% probability existed that those with symptoms of allergic rhinitis or asthma would have a positive specific IgE test.
  
  
  CONCLUSIONS
  Self-reported histories of hay fever or asthma alone are only modest predictors of allergic sensitization. When knowledge of allergic sensitization is important, information beyond self-reported symptoms is necessary.
authors.affiliation: Section of Allergy and Immunology, Medical College of Georgia, Augusta, GA 30912, USA.
authors.forename: Christina M
authors.initials: CM
authors.lastname: Abraham
authors.forename: Dennis R
authors.initials: DR
authors.lastname: Ownby
authors.forename: Edward L
authors.initials: EL
authors.lastname: Peterson
authors.forename: Ganesa
authors.initials: G
authors.lastname: Wegienka
authors.forename: Edward M
authors.initials: EM
authors.lastname: Zoratti
authors.forename: L Keoki
authors.initials: LK
authors.lastname: Williams
authors.forename: Christine L M
authors.initials: CL
authors.lastname: Joseph
authors.forename: Christine Cole
authors.initials: CC
authors.lastname: Johnson
mesh_terms: D000328:Adult; D000485:Allergens / Q000276:immunology; D001249:Asthma / Q000097:blood / Q000453:epidemiology* / Q000276:immunology; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000175:diagnosis / Q000453:epidemiology*; D007073:Immunoglobulin E / Q000097:blood*; D008875:Middle Aged; D011247:Pregnancy; D015995:Prevalence; D006255:Rhinitis, Allergic, Seasonal / Q000097:blood / Q000453:epidemiology* / Q000276:immunology; D012882:Skin Tests
chemical_list: D000485:Allergens; D007073:Immunoglobulin E