title: Treatment of human acute schistosomiasis with oxamniquine induces an increase in interferon-gamma response to Schistosoma mansoni antigens.
abstract: Patients with acute schistosomiasis were studied before and after oxamniquine treatment. They had been exposed to cercariae 5 to 9 weeks before, and presented compatible clinical manifestations, eosinophilia, and high levels of total IgE. Interferon-gamma (IFN-gamma) and interleukin-4 were measured by ELISA in whole blood samples under soluble egg antigen or soluble adult worm preparation stimulation. After treatment, the reduction of leukocytosis and eosinophilia were not significant, but total IgE levels decreased significantly, in contrast to IFN-gamma levels that were significantly increased. The oxamniquine treatment of acute schistosomiasis patients is followed by an improvement of a Th1 response in vitro. If this response has a protective aspect is unknown, and some investigations need to be realized.
authors.affiliation: Departamento de Bioquímica, Universitária, 52020-020 Recife, PE, Brasil.
authors.forename: Joelma R
authors.initials: JR
authors.lastname: de Souza
authors.forename: Clarice N L
authors.initials: CN
authors.lastname: Morais
authors.forename: Marcílio L
authors.initials: ML
authors.lastname: Aroucha
authors.forename: Paulo J C
authors.initials: PJ
authors.lastname: Miranda
authors.forename: Constança S
authors.initials: CS
authors.lastname: Barbosa
authors.forename: Ana Lúcia C
authors.initials: AL
authors.lastname: Domingues
authors.forename: Luiz B
authors.initials: LB
authors.lastname: Carvalho Júnior
authors.forename: Frederico G C
authors.initials: FG
authors.lastname: Abath
authors.forename: Silvia M L
authors.initials: SM
authors.lastname: Montenegro
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000818:Animals; D000909:Antibodies, Helminth / Q000097:blood; D000947:Antigens, Helminth / Q000276:immunology*; D002648:Child; D004196:Disease Outbreaks; D004797:Enzyme-Linked Immunosorbent Assay; D005243:Feces / Q000469:parasitology; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D007371:Interferon-gamma / Q000096:biosynthesis* / Q000276:immunology; D008297:Male; D010073:Oxamniquine / Q000627:therapeutic use*; D010270:Parasite Egg Count; D012550:Schistosoma mansoni / Q000276:immunology*; D012555:Schistosomiasis mansoni / Q000097:blood / Q000188:drug therapy* / Q000276:immunology; D012556:Schistosomicides / Q000627:therapeutic use*
chemical_list: D000909:Antibodies, Helminth; D000947:Antigens, Helminth; D012556:Schistosomicides; D010073:Oxamniquine; D007073:Immunoglobulin E; D007371:Interferon-gamma