IKKalpha at the crossroads of inflammation and metastasis.
The development of solid tumors is regulated by dynamic interactions between evolving neoplastic cells and their microenvironment. Luo et al. (2007) recently demonstrated that tumor-infiltrating immune cells expressing RANKL induce activation and nuclear localization of IKKalpha in prostatic epithelial tumor cells. This leads to repression of maspin, a critical suppressor of metastasis, and thus commits malignant prostatic epithelial cells to a metastatic fate.
Affara
Nesrine I
NI
Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA.
Coussens
Lisa M
LM
D000818:Animals; D004847:Epithelial Cells; D016147:Genes, Tumor Suppressor; D006801:Humans; D051550:I-kappa B Kinase / Q000378:metabolism*; D007249:Inflammation / Q000276:immunology / Q000378:metabolism*; D016246:Lymphocytes, Tumor-Infiltrating / Q000276:immunology / Q000378:metabolism; D008264:Macrophages / Q000276:immunology / Q000378:metabolism; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D009362:Neoplasm Metastasis; D011471:Prostatic Neoplasms / Q000378:metabolism / Q000473:pathology*; D053245:RANK Ligand / Q000378:metabolism; D015843:Serpins / Q000235:genetics / Q000378:metabolism
D053245:RANK Ligand; C085344:SERPIN-B5; D015843:Serpins; D051550:I-kappa B Kinase