title: Prediction of differential adult health burden by conduct problem subtypes in males.
abstract: BACKGROUND
  A cardinal feature of the DSM-IV diagnostic criteria for conduct disorder is the distinction between childhood- vs adolescent-onset subtypes. Whether such developmental subtypes exist in the population and have different prognoses should be rigorously tested to inform the DSM-V.
  
  
  OBJECTIVE
  To evaluate the epidemiological validity of childhood- vs adolescent-onset conduct problems in a prospective birth cohort, and to assess whether life-course-persistent conduct problems are associated with a greater adult health burden.
  
  
  METHODS
  Our sample includes 526 male study members in the Dunedin Multidisciplinary Health and Development Study, a 1-year birth cohort (April 1, 1972, through March 30, 1973). Developmental trajectories were defined using prospective ratings of conduct problems at 7, 9, 11, 13, 15, 18, 21, and 26 years of age.
  
  
  METHODS
  Health burden was assessed as mental and physical health problems at 32 years of age measured via diagnostic interviews and physical examinations.
  
  
  RESULTS
  We identified the following 4 developmental subtypes of conduct problems through general growth mixture modeling: (1) childhood-onset/life-course-persistent, (2) adolescent onset, (3) childhood limited, and (4) low. At 32 years of age, study members with the life-course-persistent subtype experienced the worst health burden. To a lesser extent, those with the adolescent-onset subtype also experienced health problems. A childhood-limited subtype not specified by DSM-IV was revealed; its adult health outcomes were within the range of the cohort norm.
  
  
  CONCLUSIONS
  Results support the epidemiological validity of the DSM-IV conduct disorder distinction based on age of onset but highlight the need to also consider long-term persistence to refine diagnosis. Preventing and treating conduct problems has the potential to reduce the adult health burden.
authors.affiliation: Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London, England.
authors.forename: Candice L
authors.initials: CL
authors.lastname: Odgers
authors.forename: Avshalom
authors.initials: A
authors.lastname: Caspi
authors.forename: Jonathan M
authors.initials: JM
authors.lastname: Broadbent
authors.forename: Nigel
authors.initials: N
authors.lastname: Dickson
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Hancox
authors.forename: Honalee
authors.initials: H
authors.lastname: Harrington
authors.forename: Richie
authors.initials: R
authors.lastname: Poulton
authors.forename: Malcolm R
authors.initials: MR
authors.lastname: Sears
authors.forename: W Murray
authors.initials: WM
authors.lastname: Thomson
authors.forename: Terrie E
authors.initials: TE
authors.lastname: Moffitt
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D017668:Age of Onset; D002648:Child; D015331:Cohort Studies; D019955:Conduct Disorder / Q000145:classification* / Q000175:diagnosis*; D039721:Diagnostic and Statistical Manual of Mental Disorders; D006304:Health Status; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000175:diagnosis* / Q000453:epidemiology; D017063:Outcome Assessment, Health Care; D010808:Physical Examination; D015995:Prevalence; D011379:Prognosis; D011446:Prospective Studies; D011569:Psychiatric Status Rating Scales / Q000706:statistics & numerical data; D015203:Reproducibility of Results; D012307:Risk Factors; D012737:Sex Factors