title: Spontaneous intestinal perforation due to non-Hodgkin's lymphoma: evaluation of eight cases.
abstract: Primary intestinal lymphoma with spontaneous perforation and after systemic chemotherapy is rare. The present study summarizes retrospectively the outcome of eight free intestinal perforated patients diagnosed with intestinal non-Hodgkin's lymphoma. Two patients had a history of systemic chemotherapy before perforation. The most common symptoms of the patients were abdominal pain, nausea, vomiting, weight loss, and fever. Sites of perforation were ileum in four, jejunum in two, cecum in one, and sigmoid colon in one patient. Synchronous lymphoma was present in three patients. The perforation was closed by primary closure in three patients. Resection/anastomosis was performed in four patients and sigmoid colostomy was performed in one patient. Three patients were lost due to leakage or septicemia. Intestinal lymphoma might be kept in mind as a cause in free intestinal perforations. Because of the high mortality rate early diagnosis and treatment are important to improve the prognosis of bowel perforation in patients with non-Hodgkin's lymphoma.
authors.affiliation: Department of General Surgery, Inonu University School of Medicine, Malatya, 44069, Turkey. cara@inonu.edu
authors.forename: Cengiz
authors.initials: C
authors.lastname: Ara
authors.forename: Sacid
authors.initials: S
authors.lastname: Coban
authors.forename: Cuneyt
authors.initials: C
authors.lastname: Kayaalp
authors.forename: Sezai
authors.initials: S
authors.lastname: Yilmaz
authors.forename: Vedat
authors.initials: V
authors.lastname: Kirimlioglu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D005260:Female; D006801:Humans; D007414:Intestinal Neoplasms / Q000150:complications*; D007416:Intestinal Perforation / Q000209:etiology*; D008228:Lymphoma, Non-Hodgkin / Q000150:complications*; D008297:Male; D008875:Middle Aged