Serum differentially alters the antifungal properties of echinocandin drugs.
Antifungal efficacies of the echinocandin drugs caspofungin, micafungin, and anidulafungin were reduced significantly in the presence of 50% human serum, which yielded nearly equivalent MICs or minimum effective concentrations against diverse Candida spp. and Aspergillus spp. Consistent with a direct drug interaction, serum decreased the sensitivity of glucan synthase to echinocandin drugs.
Paderu
Padmaja
P
Public Health Research Institute, 225 Warren St., Newark, NJ 07103, USA.
Garcia-Effron
Guillermo
G
Balashov
Sergey
S
Delmas
Guillaume
G
Park
Steven
S
Perlin
David S
DS
D000077612:Anidulafungin; D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001232:Aspergillus fumigatus / Q000145:classification / Q000187:drug effects* / Q000201:enzymology; D002176:Candida albicans / Q000145:classification / Q000187:drug effects* / Q000201:enzymology; D000077336:Caspofungin; D004347:Drug Interactions; D025141:Drug Resistance, Fungal; D054714:Echinocandins; D005964:Glucosyltransferases / Q000037:antagonists & inhibitors; D006801:Humans; D055666:Lipopeptides; D008074:Lipoproteins / Q000494:pharmacology / Q000627:therapeutic use; D000077551:Micafungin; D051379:Mice; D008807:Mice, Inbred BALB C; D008826:Microbial Sensitivity Tests / Q000592:standards; D010456:Peptides, Cyclic / Q000494:pharmacology* / Q000627:therapeutic use; D044967:Serum
D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D008074:Lipoproteins; D010456:Peptides, Cyclic; D000077612:Anidulafungin; D005964:Glucosyltransferases; C040232:glucan synthase; D000077336:Caspofungin; D000077551:Micafungin