A case of interleukin-12 receptor beta-1 deficiency with recurrent leishmaniasis.
Interleukin-12 receptor beta-1 (IL-12Rbeta1) defect is generally associated with selective susceptibility to weakly pathogenic mycobacteria and Salmonella species. Patients rarely experience infections caused by other organisms. We report a 5-year-old patient with IL-12Rbeta1 deficiency who developed recurrent visceral leishmaniasis 6 months apart. The patient responded to lyposomal amphotericin B treatment reasonably well.
Sanal
Ozden
O
Divisions of Immunology, Hacettepe University Children's Hospital, Ankara, Turkey. sanaloz@tr.net
Turkkani
Gulten
G
Gumruk
Fatma
F
Yel
Leman
L
Secmeer
Gulten
G
Tezcan
Ilhan
I
Kara
Ates
A
Ersoy
Fugen
F
D000666:Amphotericin B / Q000627:therapeutic use; D000890:Anti-Infective Agents / Q000627:therapeutic use; D000981:Antiprotozoal Agents / Q000627:therapeutic use; D002675:Child, Preschool; D002939:Ciprofloxacin / Q000627:therapeutic use; D020022:Genetic Predisposition to Disease; D006801:Humans; D007898:Leishmaniasis, Visceral / Q000188:drug therapy / Q000235:genetics* / Q000276:immunology* / Q000517:prevention & control; D008297:Male; D053707:Receptors, Interleukin-12 / Q000172:deficiency* / Q000235:genetics / Q000378:metabolism; D012008:Recurrence; D012480:Salmonella Infections / Q000188:drug therapy / Q000235:genetics / Q000276:immunology
D000890:Anti-Infective Agents; D000981:Antiprotozoal Agents; C508438:IL12RB1 protein, human; D053707:Receptors, Interleukin-12; C068538:liposomal amphotericin B; D002939:Ciprofloxacin; D000666:Amphotericin B