title: Adaptation of a quantitative trait to a moving optimum.
abstract: We investigate adaptive evolution of a quantitative trait under stabilizing selection with a moving optimum. We characterize three regimes, depending on whether (1) the beneficial mutation rate, (2) the fixation time, or (3) the rate of environmental change is the limiting factor for adaptation. If the environment is rate limiting, mutations with a small phenotypic effect are preferred over large mutations, in contrast to standard theory.
authors.affiliation: Section of Evolutionary Biology, Department Biology II, Ludwig-Maximilian-University, Munich, Germany. kopp@zi.biologie.uni-muenchen.de
authors.forename: Michael
authors.initials: M
authors.lastname: Kopp
authors.forename: Joachim
authors.initials: J
authors.lastname: Hermisson
mesh_terms: D000483:Alleles; D000818:Animals; D005075:Biological Evolution; D003198:Computer Simulation; D008957:Models, Genetic; D016296:Mutagenesis / Q000235:genetics; D019655:Quantitative Trait, Heritable; D012641:Selection, Genetic