title: Anti-inflammatory and immunomodulatory strategies to protect the perinatal brain.
abstract: Infection and inflammation contribute to perinatal brain damage, particularly to the white matter. Although combating perinatal inflammation can be dangerous, because inflammation might have beneficial effects for mother and fetus, it is worthwhile reviewing potential anti-inflammatory neuroprotective compounds, along with their potential adverse effects. Further research on the possible neuroprotective roles of existing medications and substances is necessary.
authors.affiliation: Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Tufts New England Medical Center, Boston, MA, USA.
authors.forename: Adam J
authors.initials: AJ
authors.lastname: Wolfberg
authors.forename: Olaf
authors.initials: O
authors.lastname: Dammann
authors.forename: Pierre
authors.initials: P
authors.lastname: Gressens
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001921:Brain / Q000187:drug effects; D004660:Encephalitis / Q000188:drug therapy* / Q000503:physiopathology*; D005260:Female; D006801:Humans; D018696:Neuroprotective Agents / Q000494:pharmacology* / Q000627:therapeutic use; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious
chemical_list: D000893:Anti-Inflammatory Agents; D018696:Neuroprotective Agents