title: Impact of heart failure and left ventricular function on long-term survival--report of a community-based cohort study in Taiwan.
abstract: BACKGROUND
  There is little community-based information on heart failure (HF) prognosis in ethnic Chinese populations, in whom there is a low prevalence of coronary heart disease.
  
  
  OBJECTIVE
  To study the impact of HF and left ventricular function on long-term all-cause mortality.
  
  
  RESULTS
  This community-based prospective cohort study included 2660 subjects (1215 men, 1445 women, mean age 54.4+/-11.9 years) over a 10 year follow-up period. The prevalence of HF was 5.5%. Hypertension was the most common factor related to HF. The five and ten year all-cause mortality was higher in the HF/preserved LVEF group (14.1% and 24.4%) and the HF/impaired LVEF group (29.2% and 48.2%) than in the HF-free group (6.0% and 14.6%, p<0.0001 for both). In multivariable Cox analyses, controlling for sex, LV mass, atrial fibrillation, hypertension, coronary heart disease, HF/preserved LVEF and HF/impaired LVEF were important predictors of all-cause mortality (p=0.007).
  
  
  CONCLUSIONS
  Hypertension is a major heart failure related disease. HF and LV systolic dysfunction are associated with a significant increase in all-cause mortality in an ethnic Chinese population.
authors.affiliation: Department of Emergency Medicine, National Taiwan University Medical College and National Taiwan University Hospital, Taipei, Taiwan.
authors.forename: Chien-Hua
authors.initials: CH
authors.lastname: Huang
authors.forename: Kuo-Liong
authors.initials: KL
authors.lastname: Chien
authors.forename: Wen-Jone
authors.initials: WJ
authors.lastname: Chen
authors.forename: Fung-Chang
authors.initials: FC
authors.lastname: Sung
authors.forename: Hsiu-Ching
authors.initials: HC
authors.lastname: Hsu
authors.forename: Ta-Chen
authors.initials: TC
authors.lastname: Su
authors.forename: Yuan-Teh
authors.initials: YT
authors.lastname: Lee
mesh_terms: D000328:Adult; D000368:Aged; D002423:Cause of Death; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D006333:Heart Failure / Q000401:mortality / Q000503:physiopathology*; D006801:Humans; D006973:Hypertension / Q000401:mortality / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D016019:Survival Analysis; D017741:Survivors; D013624:Taiwan; D018487:Ventricular Dysfunction, Left / Q000401:mortality / Q000503:physiopathology*