Transcatheter arterial embolization of renal VX-2 carcinoma: ethiodol-ethanol capillary embolization combined with carboplatin.
OBJECTIVE
We wanted to determine whether transcatheter Ethiodol-based capillary embolization in combination with carboplatin could improve the efficiency of a 1:1 Ethiodol-ethanol mixture (EEM) to ablate kidneys that been inoculated with VX-2 carcinoma.


METHODS
The right kidney in 34 New Zealand white rabbits were inoculated with fresh VX-2 tumor fragments. One week later, the kidneys were subjected to transarterial treatment (4-5 rabbits/group): Saline infusion (Group 1); carboplatin infusion (5 or 10 mg, Groups 2A and 2B); carboplatin-Ethiodol (CE) alone (Group 3) and followed by main renal artery occlusion with ethanol (RAO) (Group 4); carboplatin-EEM (C-EEM) followed by RAO (Group 5); carboplatin infusion followed by EEM plus RAO (Group 6); and EEM followed by RAO (Group 7). The animals were followed for up to 3-weeks. The treated kidneys were evaluated angiographically and macroscopically. The kidneys that showed successful embolization macroscopically were entirely cut into serial sections, and these were examined microscopically. Histologically, the kidneys were evaluated on the basis of the residual tumor found in the serial sections.


RESULTS
The results obtained with carboplatin infusion alone (Groups 2A and 2B) and CE without RAO (Group 3) were similar to those of the control animals (Group 1). Kidneys from Groups 4-7 demonstrated macroscopically successful embolization with histologically proven complete renal parenchyma infarction; however, some residual tumor was evident in all but one animal.


CONCLUSIONS
None of the Ethiodol-based modalities combined with locoregional carboplatin were more efficacious for tumor ablation than EEM alone.
Kónya
András
A
Vascular and Interventional Radiology, Division of Diagnostic Imaging, Unit 057, The University of Texas MD Anderson Cancer Center, TX 77030, USA. akonya@mdanderson.org
Choi
Byung Gil
BG
Van Pelt
Carolyn S
CS
Wright
Kenneth C
KC
D000792:Angiography; D000818:Animals; D016190:Carboplatin / Q000008:administration & dosage*; D016461:Chemoembolization, Therapeutic / Q000379:methods*; D000431:Ethanol / Q000008:administration & dosage*; D004998:Ethiodized Oil / Q000008:administration & dosage*; D007269:Injections, Intra-Arterial; D007680:Kidney Neoplasms / Q000628:therapy*; D011817:Rabbits; D018709:Statistics, Nonparametric
D000431:Ethanol; D004998:Ethiodized Oil; D016190:Carboplatin