[Effect of dimethoate on dopamines neurotransmitters in brain regions of rat].
OBJECTIVE
To observe changes of dopamine and its metabolite (3,4-hydroxyphenylaceticacid, DOPAC) levels of the brain regions in rats exposed by dimethoate (DM).


METHODS
Groups of rats were treated with saline and 38.9, 83.7 and 180.0 mg/kg DM respectively, and were decapitated at different time course from 0.5 to 24 hours after the administration. The dopamine neurotransmitters and its metabolite were determined by reverse-phase high-performance liquid chromatography with electrochemical detection.


RESULTS
The concentrations of DA (28% - 122% of control) and DOPAC (89% - 538% of control) varied according with the DM dose and the exposure time.


CONCLUSIONS
These results indicated that DM-induced toxic effects could alter the dopamine levels after the different dose and time exposure in the brain regions of rats.
Ruan
Guohong
G
School of Public Health, Fudan University, Key Lab. of Public Health Safety of Education Ministry, Shanghai 200032, China.
Wu
Qiang'en
Q
Wu
Qing
Q
Zheng
Lixing
L
D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism*; D001933:Brain Stem / Q000378:metabolism; D002540:Cerebral Cortex / Q000378:metabolism; D002800:Cholinesterase Inhibitors / Q000633:toxicity; D004117:Dimethoate / Q000633:toxicity*; D004298:Dopamine / Q000378:metabolism*; D006624:Hippocampus / Q000378:metabolism; D008297:Male; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
D002800:Cholinesterase Inhibitors; D015102:3,4-Dihydroxyphenylacetic Acid; D004298:Dopamine; D004117:Dimethoate