An angiotensin II receptor antagonist suppresses running-enhanced hippocampal neurogenesis in rat.
Hippocampal neurogenesis is enhanced by voluntary running exercise in adult mammals. To elucidate the factors involved in this enhancement, we examined the effects of losartan, an antagonist of angiotensin II type 1 receptors, on the running-enhanced neurogenesis in the adult rat hippocampus. When losartan was administered orally via the drinking water, the running-enhanced cell proliferation in the subgranular zone was almost completely suppressed, indicating that this enhancement may be mediated by angiotensin II and its receptors.
Mukuda
Takao
T
Department of Biology, Graduate School of Science, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan.
Sugiyama
Hiroyuki
H
D047228:Angiotensin II Type 1 Receptor Blockers / Q000494:pharmacology*; D000818:Animals; D001522:Behavior, Animal; D001973:Bromodeoxyuridine / Q000378:metabolism; D002452:Cell Count; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004326:Drinking / Q000187:drug effects; D006624:Hippocampus / Q000166:cytology* / Q000187:drug effects; D019808:Losartan / Q000494:pharmacology*; D008297:Male; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D038081:Organogenesis / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D012420:Running / Q000502:physiology*; D013997:Time Factors
D047228:Angiotensin II Type 1 Receptor Blockers; D001973:Bromodeoxyuridine; D019808:Losartan