title: Physical activity and white matter lesion progression: assessment using MRI.
abstract: We evaluated the association between physical activity and changes in white matter lesions (WMLs) on MRI in a sample of 179 older adults comprising 59 incident cases of Alzheimer disease, 60 persons with mild cognitive impairment, and 60 persons who remained cognitively stable over a median 5-year follow-up. Physical activity was not significantly associated with a decreased rate of periventricular or deep WML progression.
authors.affiliation: Department of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. lpp8@cdc.gov
authors.forename: L J
authors.initials: LJ
authors.lastname: Podewils
authors.forename: E
authors.initials: E
authors.lastname: Guallar
authors.forename: N
authors.initials: N
authors.lastname: Beauchamp
authors.forename: C G
authors.initials: CG
authors.lastname: Lyketsos
authors.forename: L H
authors.initials: LH
authors.lastname: Kuller
authors.forename: P
authors.initials: P
authors.lastname: Scheltens
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D000544:Alzheimer Disease / Q000453:epidemiology* / Q000473:pathology*; D003072:Cognition Disorders / Q000453:epidemiology* / Q000473:pathology; D015331:Cohort Studies; D003711:Demyelinating Diseases / Q000453:epidemiology* / Q000473:pathology*; D018450:Disease Progression; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000706:statistics & numerical data; D008297:Male; D009043:Motor Activity; D014481:United States / Q000453:epidemiology