title: The centrosome opens the way to mitosis.
abstract: During mitosis, the interaction between chromosomes and microtubules requires nuclear envelope disassembly in prophase. Two articles in this issue of Developmental Cell show that centrosomes have a role in promoting nuclear envelope breakdown (Hachet et al., 2007; Portier et al., 2007). Surprisingly, the role of the centrosome in this process is independent of its role as a microtubule nucleation organelle. Instead, the centrosome seems to act as a spatial regulator for the activation of the Aurora A kinase.
authors.affiliation: Wellcome Trust/Cancer Research UK Gurdon Institute, Tennis Court Road, Cambridge, CB2 1QR United Kingdom. r.basto@gurdon.cam.ac.uk
authors.forename: Renata
authors.initials: R
authors.lastname: Basto
authors.forename: Jonathon
authors.initials: J
authors.lastname: Pines
mesh_terms: D000818:Animals; D064127:Aurora Kinases; D017173:Caenorhabditis elegans / Q000196:embryology / Q000235:genetics; D018385:Centrosome / Q000378:metabolism*; D002875:Chromosomes / Q000235:genetics; D008870:Microtubules / Q000235:genetics / Q000502:physiology; D008938:Mitosis; D009685:Nuclear Envelope / Q000235:genetics* / Q000502:physiology; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D008941:Spindle Apparatus
chemical_list: D064127:Aurora Kinases; D017346:Protein Serine-Threonine Kinases