Crucial roles for chromatin dynamics in cellular memory.
Cellular memory is defined as a long-term maintenance of a particular pattern of gene expression through many rounds of cell division or even after cell division. It is critical for development and differentiation of multicellular organisms. Chromatin dynamics including histone modification, histone replacement and chromatin remodeling play key roles in cellular memory.
Hirose
Susumu
S
Department of Developmental Genetics, National Institute of Genetics, Sokendai, Japan. shirose@lab.nig.ac.jp
D000818:Animals; D002454:Cell Differentiation; D019070:Cell Lineage; D002843:Chromatin / Q000502:physiology*; D029721:Drosophila Proteins / Q000502:physiology; D044127:Epigenesis, Genetic / Q000502:physiology; D005786:Gene Expression Regulation / Q000502:physiology; D020868:Gene Silencing / Q000502:physiology; D006570:Heterochromatin / Q000235:genetics*; D063150:Polycomb Repressive Complex 1
D002843:Chromatin; D029721:Drosophila Proteins; D006570:Heterochromatin; C066770:Pc protein, Drosophila; D063150:Polycomb Repressive Complex 1