title: Primary papillary serous carcinoma of the peritoneum: report of a case with diagnosis by fine needle aspiration and immunocytochemistry.
abstract: BACKGROUND
  Primary papillary serous carcinoma (PPSC) of the peritoneum is a rare neoplasm, histologically indistinguishable from papillary serous carcinoma of the ovary, which diffusely involves the peritoneum but spares or minimally invades the ovaries. To the best of our knowledge, the preoperative and the fine needle aspiration diagnosis of this disorder have not been reported before.
  
  
  METHODS
  A woman developed an extensive peritoneal neoplasm 4 years after hysterectomy and bilateral salpingo-oophorectomy for benign disease. Fine needle aspiration of the tumor was performed, and the cytologic and immunocytochemical findings were consistent with papillary serous carcinoma. A diagnosis of PPSC of the peritoneum was rendered because review of all slides from previous surgical specimens showed no evidence of carcinoma and no other primary tumors were found elsewhere.
  
  
  CONCLUSIONS
  Fine needle aspiration cytology coupled with immunocytochemical and clinical data allows an unequivocal preoperative diagnosis of papillary serous carcinoma (primary peritoneal or with an ovarian origin). The sole limitation to establish a primary peritoneal origin before surgery is the requirement to histologically study the ovaries. Based on this fact, the preoperative fine needle aspiration cytology diagnosis of PSCP should be restricted to oophorectomized patients.
authors.affiliation: Department of Pathology, "12 de Octubre" University Hospital, Madrid, Spain.
authors.forename: Nuria
authors.initials: N
authors.lastname: Alberti
authors.forename: Anastasio
authors.initials: A
authors.lastname: Serrano-Egea
authors.forename: Elena
authors.initials: E
authors.lastname: García-García
authors.forename: Claudio
authors.initials: C
authors.lastname: Ballestín
authors.forename: Andrés
authors.initials: A
authors.lastname: Pérez-Barrios
authors.forename: Fernando
authors.initials: F
authors.lastname: López-Ríos
authors.forename: Pedro
authors.initials: P
authors.lastname: de Agustín
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001201:Ascites / Q000209:etiology; D014408:Biomarkers, Tumor / Q000032:analysis / Q000096:biosynthesis; D044963:Biopsy, Fine-Needle / Q000379:methods; D018283:Cystadenocarcinoma, Papillary / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology; D018284:Cystadenocarcinoma, Serous / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007044:Hysterectomy; D007150:Immunohistochemistry / Q000379:methods; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology; D010534:Peritoneal Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology; D016066:Pleural Effusion, Malignant / Q000209:etiology / Q000473:pathology; D011237:Predictive Value of Tests; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor