title: Two indolocarbazole alkaloids with apoptosis activity from a marine-derived actinomycete Z(2)039-2.
abstract: Bioassay-guided fractionation of the EtOAc extract from the fermentation broth of a marine-derived actinomycete Z(2)039-2 led to the isolation of two known indolocarbazole alkaloids, K252c (1) and arcyriaflavin A (2). 1 and 2 exhibited moderate cytotoxic activities against the K562 cell line, and induced apoptotic activities at 10 and 100 microM, respectively. This is the first report on the significant apoptosis inducing effect of indolocarbazole alkaloids against K562 cancer cells.
authors.affiliation: Key laboratory of Marine Drugs, Chinese Ministry of Education, Qingdao 266003, PR China.
authors.forename: Rui
authors.initials: R
authors.lastname: Liu
authors.forename: Tianjiao
authors.initials: T
authors.lastname: Zhu
authors.forename: Dehai
authors.initials: D
authors.lastname: Li
authors.forename: Jingyan
authors.initials: J
authors.lastname: Gu
authors.forename: Wei
authors.initials: W
authors.lastname: Xia
authors.forename: Yuchun
authors.initials: Y
authors.lastname: Fang
authors.lastname: HongbingLiu
authors.forename: Weiming
authors.initials: W
authors.lastname: Zhu
authors.forename: Qianqun
authors.initials: Q
authors.lastname: Gu
mesh_terms: D039903:Actinobacteria / Q000378:metabolism*; D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects*; D002227:Carbazoles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D007211:Indoles / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D020014:K562 Cells; D009682:Magnetic Resonance Spectroscopy; D014871:Water Microbiology
chemical_list: D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D002227:Carbazoles; D007211:Indoles