title: Fractionated conformal radiotherapy in vestibular schwannoma: early results from a single centre.
abstract: OBJECTIVE
  To assess the local control and cranial nerve toxicity in vestibular schwannoma patients treated with fractionated conformal radiotherapy delivered using a linear accelerator.
  
  
  METHODS
  Ninety-five patients were referred for consultation to the Oncology Department in Addenbrookes Hospital between 1996 and 2005. The 42 cases who received fractionated conformal radiotherapy are the subject of this analysis. All patients had radiological or symptomatic progression. Conformal radiotherapy was prescribed at 50Gy in 30 fractions over 6 weeks, delivered using a linear accelerator. Patients were immobilised using either a beam direction shell or a Gill Thomas Cosman relocatable stereotactic head frame.
  
  
  RESULTS
  The median age was 63 years (range 28-81) with 57% men. The average tumour size was 21.5mm on magnetic resonance imaging. Before treatment, 20 (48%) patients were deemed to have useful hearing on the affected side. The median follow-up was 18.6 months (range 0.3-6.5 years) and the actuarial local control rate at 2.5 years was 96.9% (one patient progressed after treatment). In previously hearing patients, the actuarial rate of useful hearing preservation was 100%, and the rate of mild hearing loss was 20% at 1 year and 26.7% at 2.5 years of follow-up. There were five neurofibromatosis type 2 patients treated, two of whom had useful hearing before radiotherapy. In one patient this was affected, with a 20dB loss, although he still has useful hearing. In those with normal facial nerve function before radiotherapy (n=40), this was preserved in 96.8% at 2.5 years. Trigeminal nerve function was preserved in all patients (n=38) who had normal nerve function before radiotherapy.
  
  
  CONCLUSIONS
  Although follow-up was relatively short in this single institution series, fractionated linear accelerator radiotherapy gave excellent local control, useful hearing preservation and retained cranial nerve function in vestibular schwannoma.
authors.affiliation: Oncology Centre, Addenbrookes Hospital, Cambridge, UK. ghoran@doctors.org.uk
authors.forename: G
authors.initials: G
authors.lastname: Horan
authors.forename: G A
authors.initials: GA
authors.lastname: Whitfield
authors.forename: K E
authors.initials: KE
authors.lastname: Burton
authors.forename: N G
authors.initials: NG
authors.lastname: Burnet
authors.forename: S J
authors.initials: SJ
authors.lastname: Jefferies
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003391:Cranial Nerves / Q000528:radiation effects; D019583:Dose Fractionation, Radiation; D005260:Female; D006309:Hearing / Q000528:radiation effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009464:Neuroma, Acoustic; D020266:Radiotherapy, Conformal / Q000009:adverse effects / Q000379:methods*; D013238:Stereotaxic Techniques