title: [Surgical treatment of Parkinson's disease as a supplement to pharmacological therapy].
abstract: The aim of the study was review of literature and description of surgical treatment of Parkinson's disease, based on neuroanatomical and neurophysiological aspects ofnigrostriatal system. Parkinson's disease is the neurodegenerative disorder characterized by dopaminergic cell loss in the compact part of substantia nigra. It is treated pharmacologically or surgically. The surgical treatment is the supplement to the pharmacological one in severe and drug resistant cases. In this study the common methods of surgical treatment of Parkinson's disease: ablative lesions and deep brain stimulation procedures in globus pallidus internus, thalamus and subthalamic nucleus and also the intrastriatal transplantation ofdopaminergic cells (into the striatum) were described.
authors.affiliation: Katedry i Kliniki Chirurgii Przewodu Pokarmowego, Slaskiej Akademii Medycznej w Katowicach.
authors.forename: Beata
authors.initials: B
authors.lastname: Jabłońska
authors.forename: Józefa
authors.initials: J
authors.lastname: Dabek
authors.forename: Tomasz
authors.initials: T
authors.lastname: Lepich
mesh_terms: D016380:Brain Tissue Transplantation; D003342:Corpus Striatum / Q000503:physiopathology / Q000601:surgery; D046690:Deep Brain Stimulation; D004298:Dopamine / Q000378:metabolism; D018491:Dopamine Agonists / Q000627:therapeutic use; D004599:Electric Stimulation Therapy / Q000009:adverse effects / Q000295:instrumentation / Q000379:methods*; D004567:Electrodes, Implanted / Q000009:adverse effects; D004598:Electrosurgery / Q000379:methods; D016332:Fetal Tissue Transplantation; D006801:Humans; D010300:Parkinson Disease / Q000188:drug therapy / Q000503:physiopathology / Q000601:surgery*; D013238:Stereotaxic Techniques; D016896:Treatment Outcome
chemical_list: D018491:Dopamine Agonists; D004298:Dopamine