Emerging technologies for genome-wide DNA methylation profiling in cancer.
Genome-wide epigenetics, namely, epigenomics, is one of the current frontiers in cancer genomics. Epigenetic silencing of tumor-suppressor genes plays an important role in the pathogenesis of most cancers. Several technologies are emerging for the genome-wide profiling of DNA methylation to find new tumor-suppressor genes and predictions for clinical phenotypes in individual patients.
Hatada
Izuho
I
Laboratory of Genome Science, Biosignal Genome Resource Center, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi 371-8511 Japan. ihatada@showa.gunma-u.ac.jp
D019175:DNA Methylation; D044127:Epigenesis, Genetic; D020869:Gene Expression Profiling; D016147:Genes, Tumor Suppressor; D015894:Genome, Human; D006801:Humans; D009369:Neoplasms / Q000235:genetics*; D020411:Oligonucleotide Array Sequence Analysis