title: Bone mineral density in institutionalised patients with refractory epilepsy.
abstract: Bone mineral density (BMD) and content (BMC) were measured in 208 institutionalised patients with refractory epilepsy. BMD was in the osteoporotic range in 43% of males and 21% of females. BMC was reduced only in male patients. Apart from age and gender, no other factor or specific AED was particularly associated with reduced BMD or BMC. This study indicates the magnitude of the problem of bone disease in refractory epilepsy, in particular affecting young and male patients with chronic epilepsy.
authors.affiliation: Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London and National Society for Epilepsy, Chalfont St. Peter, Bucks, United Kingdom.
authors.forename: Josephine
authors.initials: J
authors.lastname: Swanton
authors.forename: Robert
authors.initials: R
authors.lastname: Simister
authors.forename: Daniel
authors.initials: D
authors.lastname: Altmann
authors.forename: Hilary
authors.initials: H
authors.lastname: Watts
authors.forename: Richard
authors.initials: R
authors.lastname: Keen
authors.forename: John S
authors.initials: JS
authors.lastname: Duncan
authors.forename: Matthias J
authors.initials: MJ
authors.lastname: Koepp
mesh_terms: D015502:Absorptiometry, Photon; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000927:Anticonvulsants / Q000627:therapeutic use; D001823:Body Composition; D015519:Bone Density / Q000187:drug effects; D004827:Epilepsy / Q000188:drug therapy / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007297:Inpatients; D008297:Male; D008875:Middle Aged
chemical_list: D000927:Anticonvulsants