Association of GST M1 null polymorphism with Parkinson's disease in a Chilean population with a strong Amerindian genetic component.
We have studied the association of a null mutation of Glutathione Transferase M1 (GST M1*0/0) with Parkinson's disease (MIM 168600) in a Chilean population with a strong Amerindian genetic component. We determined the genotype in 349 patients with idiopathic Parkinson's disease (174 female and 175 male; 66.84+/-10.7 years of age), and compared that to 611 controls (457 female and 254 male; 62+/-13.4 years of age). A significant association of the null mutation in GST M1 with Parkinson's disease was found (p=0.021), and the association was strongest in the earlier age range. An association of GSTM1*0/0 with Parkinson's disease supports the hypothesis that Glutathione Transferase M1 plays a role in protecting astrocytes against toxic dopamine oxidative metabolism, and most likely by preventing toxic one-electron reduction of aminochrome.
Perez-Pastene
Carolina
C
Molecular and Clinical Pharmacology, ICBM, Faculty of Medicine, University of Chile, Casilla 70000, Santiago-7, Chile.
Graumann
Rebecca
R
Díaz-Grez
Fernando
F
Miranda
Marcelo
M
Venegas
Pablo
P
Godoy
Osvaldo Trujillo
OT
Layson
Luis
L
Villagra
Roque
R
Matamala
Jose Manuel
JM
Herrera
Luisa
L
Segura-Aguilar
Juan
J
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000235:genetics / Q000378:metabolism; D001253:Astrocytes / Q000201:enzymology; D001921:Brain / Q000201:enzymology / Q000503:physiopathology; D002677:Chile / Q000208:ethnology; D019610:Cytoprotection / Q000235:genetics; D004252:DNA Mutational Analysis; D004298:Dopamine / Q000378:metabolism; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005820:Genetic Testing; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D007199:Indians, South American / Q000208:ethnology / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009154:Mutation; D018384:Oxidative Stress / Q000235:genetics*; D010300:Parkinson Disease / Q000201:enzymology* / Q000208:ethnology / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*
D004298:Dopamine; D005982:Glutathione Transferase