title: [Endocrine orbitopathy and significance of autoantibodies against 1D protein].
abstract: BACKGROUND
  Endocrine ophthalmopathy is a chronic eye disease, characterized by inflammation in parabulbar and retrobulbar space, occurring usually in Graves' thyrotoxicosis. Although the pathogenesis of the disease has not been clarified until now, it is accepted that this disease is of an autoimmune nature, where the targets of the autoimmune reaction are the antigens shared by thyroid and orbit-tissue. The autoantibodies against recombinant 1D protein are highly specific and sensitive for the diagnosis of endocrine orbitopathy.
  
  
  RESULTS
  The aim of our study was to establish, whether the autoantibodies against 1D protein are found predominantly in patients with clinically expressed endocrine orbitopathy. We evaluated in 30 patients with clinically expressed endocrine orbitopathy the thickness of the three retrobulbar eye muscles, damaged by endocrine orbitopathy, determined the parameters of thyroid hormones and anti-TSH receptor autoantibodies. In all patients the detection of circulating autoantibodies against recombinant 1D protein was performed. Autoantibodies against recombinant 1D protein were found in all patients with clinically expressed endocrine orbitopathy.
  
  
  CONCLUSIONS
  Immunoreactivity did not depend on the duration or severity of the eye disease, neither on patients' age. We did not find any correlation between the thickness of eye muscles and the titre of anti-TSH receptor autoantibodies, levels of ssTSH and free thyroxine and also any correlation between the thickness of eye muscles and the disease duration.
authors.affiliation: Endokrinologický ústav, Praha. phrda@endo.cz
authors.forename: P
authors.initials: P
authors.lastname: Hrdá
authors.forename: I
authors.initials: I
authors.lastname: Sterzl
authors.forename: S
authors.initials: S
authors.lastname: Vána
authors.forename: Z
authors.initials: Z
authors.lastname: Novák
authors.forename: P
authors.initials: P
authors.lastname: Matucha
authors.forename: A
authors.initials: A
authors.lastname: Kromminga
mesh_terms: D001323:Autoantibodies / Q000032:analysis*; D001324:Autoantigens / Q000276:immunology*; D015415:Biomarkers / Q000032:analysis; D003598:Cytoskeletal Proteins / Q000276:immunology*; D005260:Female; D049970:Graves Ophthalmopathy / Q000276:immunology* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009801:Oculomotor Muscles / Q000473:pathology; D011989:Receptors, Thyrotropin / Q000276:immunology; D011994:Recombinant Proteins / Q000276:immunology
chemical_list: D001323:Autoantibodies; D001324:Autoantigens; D015415:Biomarkers; D003598:Cytoskeletal Proteins; C103926:LMOD1 protein, human; D011989:Receptors, Thyrotropin; D011994:Recombinant Proteins