Gastroprotective effects of DA-6034, a new flavonoid derivative, in various gastric mucosal damage models.
This study evaluated the gastroprotective activity of DA-6034 against various ulcerogens including ethanol, aspirin, indomethacin, stress, and acetic acid. The basic mechanisms of DA-6034 as a defensive factor such as mucus secretion and endogenous prostaglandin E(2) synthesis were determined. Rats with gastric lesions induced by ethanol-HCl, aspirin, indomethacin, and stress that had been pretreated with DA-6034 orally showed a statistically significant decrease or decreasing tendency of the gastric lesion. In acetic acid-induced gastric lesions, repeated oral administration of DA-6034 exhibited a U-shape activity in ulcer healing, with the maximum and minimum inhibition being observed at 30 and 10 mg/kg/day, respectively. DA-6034 also increased the mucus content in the gel layer as well as endogenous prostaglandin E(2) synthesis. These results suggest that DA-6034 prevents gastric mucosal injury, and these gastroprotective activities appear to be due to the increase in the gastric defensive systems.
Choi
Seul Min
SM
Research Laboratories, Dong-A Pharmaceutical Company, 47-5 Sanggal-dong, Kiheung-gu, Yongin-shi, Kyunggi-do 446-905, Korea.
Shin
Jee Hyun
JH
Kang
Kyung Koo
KK
Ahn
Byoung Ok
BO
Yoo
Moohi
M
D019342:Acetic Acid / Q000633:toxicity; D000284:Administration, Oral; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000633:toxicity; D001241:Aspirin / Q000633:toxicity; D002492:Central Nervous System Depressants / Q000633:toxicity; D015232:Dinoprostone / Q000096:biosynthesis; D004195:Disease Models, Animal; D000431:Ethanol / Q000633:toxicity; D005419:Flavonoids / Q000008:administration & dosage*; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*; D007101:Immersion; D007202:Indicators and Reagents / Q000633:toxicity; D007213:Indomethacin / Q000633:toxicity; D008297:Male; D009093:Mucus / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D012720:Severity of Illness Index; D013276:Stomach Ulcer / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D013315:Stress, Psychological / Q000150:complications; D016896:Treatment Outcome
D000894:Anti-Inflammatory Agents, Non-Steroidal; D002492:Central Nervous System Depressants; D005419:Flavonoids; D007202:Indicators and Reagents; D000431:Ethanol; D015232:Dinoprostone; D019342:Acetic Acid; D001241:Aspirin; C121889:recoflavone; D007213:Indomethacin