title: Antinociceptive and antipyretic activities of the Zizyphus oxyphylla Edgew. leaves.
abstract: A methanol extract of Zizyphus oxyphylla Edgew leaves has been investigated for its analgesic and antipyretic activities in Adult Wistar and Swiss albino mice of either sex at 50, 100 and 200 mg/kg orally. The extract demonstrated marked antipyretic activity against Brewer's yeast-induced pyrexia in rats. The extract demonstrated significant peripheral analgesic effect in the acetic acid-induced writhing test in mice. The phytochemical tests revealed that the extract contained alkaloids, anthraquinones, flavonoids, glycosides, phenols, resins, saponins and tannins using standard procedures. In conclusion, the present study suggests that the methanol extract of Zizyphus oxyphylla Edgew leaves possesses potent antipyretic and antinociceptive activities and thus validates its use in the treatment of pain and fever.
authors.affiliation: Department of Pharmacy, University of Peshawar, Peshawar 25120, Pakistan. nisaruma@yahoo.com
authors.forename: M
authors.initials: M
authors.lastname: Nisar
authors.forename: B
authors.initials: B
authors.lastname: Adzu
authors.forename: K
authors.initials: K
authors.lastname: Inamullah
authors.forename: A
authors.initials: A
authors.lastname: Bashir
authors.forename: A
authors.initials: A
authors.lastname: Ihsan
authors.forename: A H
authors.initials: AH
authors.lastname: Gilani
mesh_terms: D019342:Acetic Acid; D000700:Analgesics / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D051379:Mice; D010146:Pain / Q000139:chemically induced / Q000517:prevention & control*; D010147:Pain Measurement / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves; D051381:Rats; D017208:Rats, Wistar; D031957:Ziziphus
chemical_list: D000700:Analgesics; D018712:Analgesics, Non-Narcotic; D010936:Plant Extracts; D019342:Acetic Acid