title: Fibrous histiocytoma of the lacrimal gland.
abstract: Fibrous histiocytoma, a primary mesenchymal tumor of the orbit, is known to arise from various ocular and adnexal tissues. We are unable to find a published report of this tumor originating from the lacrimal gland. We report a case of a benign fibrous histiocytoma of the lacrimal gland in an 11 year old girl who presented with painless, progressive eyelid swelling and mild proptosis. Imaging studies revealed a discrete mass in the lacrimal gland region. The tumor was completely excised by anterolateral orbitotomy. Light microscopy showed a spindle cell tumor arising from the lacrimal gland. The tumor cells were arranged in a characteristic storiform (cartwheel) pattern with no pleomorphism or mitotic figures. Immunohistochemically, the tumor cells were focally positive for CD-68 and negative for S-100, smooth muscle actin, vimentin, and CD-34, which ruled out neurofibroma, leiomyoma, solitary fibrous tumor, and hemangiopericytoma. Based on these features, a diagnosis of benign fibrous histiocytoma was made.
authors.affiliation: Oculoplasty and Pediatric Ophthalmology Services, All India Institute of Medical Sciences, Ansari Nagar, New Delhi-110 029, India. msbajaj32@hotmail.com
authors.forename: Mandeep S
authors.initials: MS
authors.lastname: Bajaj
authors.forename: Neelam
authors.initials: N
authors.lastname: Pushker
authors.forename: Seema
authors.initials: S
authors.lastname: Kashyap
authors.forename: Seema
authors.initials: S
authors.lastname: Sen
authors.forename: Sujith
authors.initials: S
authors.lastname: Vengayil
authors.forename: Amrita
authors.initials: A
authors.lastname: Chaturvedi
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D002648:Child; D005134:Eye Neoplasms / Q000737:chemistry / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D005260:Female; D018219:Histiocytoma, Benign Fibrous / Q000737:chemistry / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007766:Lacrimal Apparatus Diseases / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D009363:Neoplasm Proteins / Q000032:analysis; D014057:Tomography, X-Ray Computed
chemical_list: D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins