How effective are lifestyle changes in the prevention of type 2 diabetes mellitus?
Obesity and impaired glucose tolerance are associated with a greater risk for a number of conditions, including insulin resistance, diabetes mellitus, hypertension, dyslipidemia, coagulation abnormalities, inflammatory markers, and coronary heart disease. Lifestyle changes can delay or prevent the development of type 2 diabetes in patients with obesity and impaired glucose tolerance. The risks improve with weight loss and increased physical activity. A decrease of 7% to 10% or more from baseline weight can have a significant effect. This has now been documented in a number of randomized, controlled studies.
Pi-Sunyer
F Xavier
FX
Columbia University, St. Luke's-Roosevelt Hospital Center, 1111 Amsterdam Avenue, New York, NY 10025, USA. fxp1@columbia.edu
D003924:Diabetes Mellitus, Type 2 / Q000517:prevention & control*; D015444:Exercise / Q000502:physiology*; D006801:Humans; D008019:Life Style; D009765:Obesity / Q000150:complications / Q000453:epidemiology; D016032:Randomized Controlled Trials as Topic; D015431:Weight Loss / Q000502:physiology*