Breast implant capsules are partially composed of bone marrow-derived cells.
Capsular contracture is the most common complication following breast augmentation or reconstruction with implants. We recently demonstrated that bone marrow-derived cells provide fibroblasts to murine skin during wound healing. To determine if bone marrow-derived cells were the cellular source of periprosthetic capsules, we created chimeric C57BL mice containing bone marrow cells from isogeneic enhanced green fluorescent protein (EGFP) mice and implanted with a textured silicone shell implant. We found that none of the mice developed infection or capsular contracture, but day 30 capsules were composed of 26.4 +/- 6.1% EGFP cells, and day 60 capsules had 21.8 +/- 10.3% EGFP cells. Immunohistochemistry revealed a small population of EGFP cells in the capsules that were myofibroblasts. Thus, breast implant capsules are partially composed of bone marrow-derived cells and, given the potential of these cells to become myofibroblasts, may explain the cellular source of capsular contracture when it develops.
Isom
Casey
C
University of Washington Medical Center, Seattle, WA 98195, USA.
Kapoor
Vishal
V
Wilson
Lynne
L
Fathke
Carrie
C
Barnes
Leigh
L
Sullivan
Stephen R
SR
Isik
F Frank
FF
D000818:Animals; D001854:Bone Marrow Cells; D018427:Breast Implants / Q000009:adverse effects*; D002678:Chimera; D003286:Contracture; D005347:Fibroblasts / Q000166:cytology*; D005549:Foreign-Body Reaction / Q000473:pathology*; D049452:Green Fluorescent Proteins; D007150:Immunohistochemistry; D051379:Mice; D008810:Mice, Inbred C57BL; D012828:Silicones / Q000009:adverse effects
D012828:Silicones; D049452:Green Fluorescent Proteins