Drug interactions between proton pump inhibitors and antiretroviral drugs.
Gastroesophageal reflux disease and other related symptoms are common comorbidities for HIV-infected patients. Therefore, concurrent use of proton pump inhibitors and antiretrovirals is a common practice in the clinical setting. However, this practice may alter antiretroviral pharmacokinetics and lead to treatment failure due to inadequate drug exposure. Clinician awareness of these complex interactions is essential for optimal HIV management. This review summarizes the current knowledge on the interactions between proton pump inhibitors and antiretrovirals, and makes recommendations for the coadministration of proton pump inhibitors.
McCabe
Sarah M
SM
Associate Dean, Clinical Education and Research, University of Buffalo, Department of Pharmacy Practice, 317 Hochstetter Hall, Buffalo, NY 14260, USA.
Smith
Patrick F
PF
Ma
Qing
Q
Morse
Gene D
GD
D000818:Animals; D044966:Anti-Retroviral Agents / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D000897:Anti-Ulcer Agents / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D005764:Gastroesophageal Reflux / Q000150:complications / Q000188:drug therapy / Q000378:metabolism; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy / Q000378:metabolism; D006801:Humans; D054328:Proton Pump Inhibitors
D044966:Anti-Retroviral Agents; D000897:Anti-Ulcer Agents; D054328:Proton Pump Inhibitors