[Changes of cognition and micronutrient levels in rats treated by beta amyloid protein].
OBJECTIVE
To observe the changes of the cognition and micronutrient level in rats treated by beta amyloid protein.


METHODS
Thirty male Sprague-Dawley rats were randomly divided into control group, beta amyloid group (Abeta) and saline group. The rats were injected Abeta and saline by bilateral intrahippocampus (10 microg per lateral) in Abeta group and saline group separately. The experiment lasted 2 weeks.The cognition was identified by water maze and step through test. The contents of serum micronutrients were examined by atomic absorption spectrometry and fluorescence spectrometry.


RESULTS
Declined cognition and prolonged latency were observed in Abeta group. The contents of serum vitamin C and iron in Abeta group were significantly lower than those of the control group and saline group (P < 0.05). There was no significant difference among the three groups in other indicators.


CONCLUSIONS
It was seemed that impaired cognition and decreases of serum vitamin C and iron level could be observed in rats treated by beta amyloid protein.
Jiang
Yugang
Y
Institute of Hygiene and Environmental Medicine, Tianjin 300050, China. jyg1967@126.com
Fang
Hengtong
H
D016229:Amyloid beta-Peptides / Q000494:pharmacology*; D000818:Animals; D003071:Cognition / Q000187:drug effects*; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D018977:Micronutrients / Q000097:blood*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
D016229:Amyloid beta-Peptides; D018977:Micronutrients