title: A facile approach to the synthesis of chiral 2-substituted benzofurans.
abstract: An effective route to chiral optically active 2-substituted benzofurans directly from carboxylic acids is reported. This procedure, which allows the preparation of alpha-alkyl-2-benzofuranmethanamines from N-protected alpha-amino acids without sensible racemization phenomena, proceeds in good yields under mild conditions with the help of microwave irradiation.
authors.affiliation: Dipartimento di Chimica, Università degli Studi di Sassari, via Vienna 2, I-07100 Sassari, Italy.
authors.forename: Lidia
authors.initials: L
authors.lastname: De Luca
authors.forename: Giampaolo
authors.initials: G
authors.lastname: Giacomelli
authors.forename: Giammario
authors.initials: G
authors.lastname: Nieddu
mesh_terms: D000478:Alkylation; D001572:Benzofurans / Q000138:chemical synthesis / Q000737:chemistry*; D002264:Carboxylic Acids / Q000737:chemistry; D005663:Furans / Q000737:chemistry*; D008872:Microwaves; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D001572:Benzofurans; D002264:Carboxylic Acids; D005663:Furans