Central physeal arrests as a manifestation of hypervitaminosis A.
Vitamin A is necessary for synthesis of visual pigments and required in appropriate amounts for membrane stability. Acute hypervitamin A intoxication can lead to increased intracranial pressure, vomiting, and lethargy. Chronic excessive intake of vitamin A can lead to pruritus, muscle and bone tenderness, and failure to thrive. Reported effects of hypervitamin A intoxication on bone include osteoporosis, fracture, cortical thickening, and metaphyseal irregularity. We are reporting on a case of central physeal arrest in the distal femur, proximal tibia, and distal tibia after excessive intake of vitamin A.
Saltzman
Matthew D
MD
Department of Orthopaedic Surgery, Northwestern University.
King
Erik C
EC
D002675:Child, Preschool; D004838:Epiphyses / Q000000981:diagnostic imaging / Q000187:drug effects*; D005269:Femur / Q000000981:diagnostic imaging / Q000187:drug effects*; D006801:Humans; D006986:Hypervitaminosis A / Q000150:complications* / Q000000981:diagnostic imaging; D008297:Male; D011859:Radiography; D013977:Tibia / Q000000981:diagnostic imaging / Q000187:drug effects*