title: Obesity and poor reproductive outcome: the potential role of the endometrium.
abstract: OBJECTIVE
  To analyze the potential role of extraovarian factors such as endometrium in the reproductive outcome of obese patients.
  
  
  METHODS
  Retrospective study.
  
  
  METHODS
  University-affiliated infertility clinic, between January 2001 and July 2005.
  
  
  METHODS
  Women undergoing a total of 2656 first ovum donation (OD) cycles with good quality embryos.
  
  
  METHODS
  The oocyte donors underwent controlled ovarian hyperstimulation, and recipients received a well-established hormonal replacement therapy for endometrial preparation. In vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) was performed according to semen characteristics. All first cycles (n = 2656) of ovum donation used good quality embryos and were divided into groups according to body mass index: <20 kg/m(2) (n = 471), 20 to 24.9 kg/m(2) (n = 1613), 25 to 29.9 kg/m(2) (n = 450), and > or =30 kg/m(2) (n = 122).
  
  
  METHODS
  The recipient body mass index groups were compared regarding IVF outcome.
  
  
  RESULTS
  The rates of implantation, pregnancy, miscarriage, and ongoing pregnancy were similar among the body mass index groups, although there was a negative trend when body mass index increased. Ongoing pregnancy rates per cycle were poorer in the overweight and obese groups than in the underweight and normal groups. In addition, women under 25 kg/m(2) presented an ongoing pregnancy rate per cycle of 45.5%, compared with 38.3% for those with > or =25 kg/m(2).
  
  
  CONCLUSIONS
  Excess weight exerts an extraovarian detrimental effect. The role of the endometrium or its environment seems to be subtle but should be taken into account.
authors.affiliation: Departments of Reproduction and Maternal-Fetal Medicine, Instituto Valenciano de Infertilidad, Universidad de Valencia, Valencia, Spain. jbellver@ivi.es <jbellver@ivi.es>
authors.forename: José
authors.initials: J
authors.lastname: Bellver
authors.forename: Marco A B
authors.initials: MA
authors.lastname: Melo
authors.forename: Ernesto
authors.initials: E
authors.lastname: Bosch
authors.forename: Vicente
authors.initials: V
authors.lastname: Serra
authors.forename: José
authors.initials: J
authors.lastname: Remohí
authors.forename: Antonio
authors.initials: A
authors.lastname: Pellicer
mesh_terms: D000022:Abortion, Spontaneous / Q000453:epidemiology / Q000209:etiology; D000293:Adolescent; D000328:Adult; D015992:Body Mass Index; D010064:Embryo Implantation; D004717:Endometrium / Q000502:physiology*; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000209:etiology* / Q000628:therapy; D009765:Obesity / Q000150:complications*; D018587:Oocyte Donation; D011247:Pregnancy; D018873:Pregnancy Rate; D012098:Reproduction; D027724:Reproductive Techniques, Assisted; D012189:Retrospective Studies; D016896:Treatment Outcome