[Study of a role of artificial mycobacterial particles in the realization of immunological processes in experimental animal tuberculosis].
The protective properties of artificial mycobacterial particles versus BCG vaccine were studied in laboratory animals with experimental tuberculosis. The findings of the decreased rate of a tuberculous process and on the increased mean life span in animals inoculated with M. bovis suggest that immunization of guinea-pigs with mycobacterial particles promotes the enhanced development of antituberculous immunity in the animals. The paper proposes a promising method for designing artificial immunogens, the high-polymer antigenic structures that imitates mycobacterial particles.
Azaev
M Sh
MSh
Lebedev
L R
LR
Kuz'micheva
G A
GA
Tumanov
Iu V
IuV
Donchenko
N A
NA
Tat'kov
S I
SI
Nosareva
O V
OV
Il'ichev
A A
AA
D000818:Animals; D001500:BCG Vaccine / Q000276:immunology*; D003627:Data Interpretation, Statistical; D004195:Disease Models, Animal; D006168:Guinea Pigs; D007114:Immunization; D007124:Immunoenzyme Techniques; D009163:Mycobacterium bovis / Q000276:immunology*; D010587:Phagocytosis; D014376:Tuberculosis / Q000276:immunology / Q000517:prevention & control*; D032581:Tuberculosis Vaccines / Q000276:immunology*; D014614:Vaccines, Synthetic / Q000276:immunology*
D001500:BCG Vaccine; D032581:Tuberculosis Vaccines; D014614:Vaccines, Synthetic