Crossing barriers in transplantation.
In 1978, Jonathan Sprent and Robert Korngold proved that graft-versus-host disease (GVHD) is caused by donor T cells that attack the host's non-MHC antigens. T cell depletion of donor grafts has since become a staple of transplantation strategies to combat leukemia and other inherited blood disorders.
Bashyam
Hema
H
hbashyam@rockefeller.edu
D016026:Bone Marrow Transplantation / Q000266:history*; D006086:Graft vs Host Disease / Q000266:history*; D049673:History, 20th Century; D049674:History, 21st Century; D013601:T-Lymphocytes / Q000637:transplantation