Role of oxidative stress in celecoxib-induced renal damage in wistar rats.
Celecoxib, a selective cyclo-oxygenase-2 (Cox-2) inhibitor, prevents the formation of prostaglandins, responsible for maintenance of renal function. Celecoxib administration may lead to renal damage. Since free radicals and antioxidant mechanisms play a significant role in renal injury; this study was designed to evaluate the role of oxidative stress in celecoxib-induced renal damage. The administration of celecoxib resulted in moderate and mild tubulointerstitial nephritis in chronic and acute group. The renal function tests were significantly altered only in the chronic group. The results in both the acute and the chronic group showed (1) a significant increase in the lipid peroxidation and in the activities of superoxide dismutase, catalase and glutathione-S-transferase and (2) a decrease in nitrite, reactive thiols and glutathione. In conclusion, our study suggests that chronic administration of celecoxib may have a damaging effect on kidney, as evident through altered histopathology and renal functions. This damage may be mediated by oxidative stress.
Gupta
Shikha
S
Department of Biochemistry, Panjab University, Chandigarh, 160014, India.
Sarotra
Pooja
P
Aggarwal
Ritu
R
Dutta
Nisha
N
Agnihotri
Navneet
N
D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D002318:Cardiovascular Diseases; D002374:Catalase / Q000378:metabolism; D000068579:Celecoxib; D003404:Creatinine / Q000097:blood; D016861:Cyclooxygenase Inhibitors / Q000633:toxicity; D004195:Disease Models, Animal; D005982:Glutathione Transferase / Q000378:metabolism; D007668:Kidney / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D009395:Nephritis, Interstitial / Q000139:chemically induced / Q000378:metabolism* / Q000473:pathology; D009573:Nitrites / Q000378:metabolism; D018384:Oxidative Stress / Q000502:physiology*; D011720:Pyrazoles / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar; D013053:Spectrophotometry; D013449:Sulfonamides / Q000633:toxicity; D013482:Superoxide Dismutase / Q000378:metabolism; D014508:Urea / Q000097:blood
D015415:Biomarkers; D016861:Cyclooxygenase Inhibitors; D009573:Nitrites; D011720:Pyrazoles; D013449:Sulfonamides; D008315:Malondialdehyde; D014508:Urea; D003404:Creatinine; D002374:Catalase; D013482:Superoxide Dismutase; D005982:Glutathione Transferase; D000068579:Celecoxib