Enantioselective organocatalytic intramolecular ring-closing Friedel-Crafts-type alkylation of indoles.
An enantioselective organocatalytic intramolecular ring-closing Friedel-Crafts-type alkylation of indolyl alpha,beta-unsaturated aldehydes has been developed. This powerful new strategy allows enantioselective access to THPIs and THBCs in a straightforward and atom-economical manner.
Li
Chang-Feng
CF
Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, Hubei, China.
Liu
Hiu
H
Liao
Jie
J
Cao
Yi-Ju
YJ
Liu
Xiao-Peng
XP
Xiao
Wen-Jing
WJ
D000447:Aldehydes / Q000737:chemistry; D000478:Alkylation; D002384:Catalysis; D018360:Crystallography, X-Ray; D003500:Cyclization; D007211:Indoles / Q000138:chemical synthesis / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D013237:Stereoisomerism
D000447:Aldehydes; D007211:Indoles