title: Outcome of in vitro fertilization treatment in infertile women conservatively treated for endometrial adenocarcinoma.
abstract: OBJECTIVE
  To evaluate IVF characteristics and outcome of infertile women conservatively treated for well-differentiated endometrial adenocarcinoma.
  
  
  METHODS
  Observational case series study.
  
  
  METHODS
  The Department of Gynecology Oncology and IVF unit of Chaim Sheba Medical center, Tel-Hashomer, Israel.
  
  
  METHODS
  Eight women referred to IVF treatment because of failure of other fertility treatments after conservative treatment of endometrial adenocarcinoma. All women were selected carefully for conservative treatment at the Department of Gynecology Oncology of the Chaim Sheba Medical Center after a thorough metastatic workup.
  
  
  METHODS
  In vitro fertilization/intracytoplasmic sperm injection treatment.
  
  
  METHODS
  Serum E(2) levels at hCG administration, endometrial thickness, number of oocytes retrieved, fertilization rate, pregnancy and delivery rate.
  
  
  RESULTS
  All women were nulliparous before IVF treatment, and only one woman was older than 35 years. In four of them, endometrial adenocarcinoma was diagnosed during infertility workup or treatment. A total of 31 IVF cycles were performed. The mean number of oocytes retrieved was 9.4 (95% confidence interval, 5.1-13.6), and fertilization rate was 58.6%. Six women (75%) conceived, and four (50%) delivered six healthy offspring.
  
  
  CONCLUSIONS
  In vitro fertilization treatment of infertile women conservatively treated for well-differentiated endometrial adenocarcinoma is highly successful and offers the opportunity to cryopreserve embryos for future use.
authors.affiliation: IVF Unit, Tel-Hashomer, Israel. shai.elizur@muhc.mcgill.ca
authors.forename: Shai E
authors.initials: SE
authors.lastname: Elizur
authors.forename: Mario E
authors.initials: ME
authors.lastname: Beiner
authors.forename: Jacob
authors.initials: J
authors.lastname: Korach
authors.forename: Amir
authors.initials: A
authors.lastname: Weiser
authors.forename: Gilad
authors.initials: G
authors.lastname: Ben-Baruch
authors.forename: Jehoshua
authors.initials: J
authors.lastname: Dor
mesh_terms: D000230:Adenocarcinoma / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D000328:Adult; D016022:Case-Control Studies; D015331:Cohort Studies; D016889:Endometrial Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007247:Infertility, Female / Q000209:etiology / Q000628:therapy*; D009364:Neoplasm Recurrence, Local; D011247:Pregnancy; D018873:Pregnancy Rate; D011372:Progestins / Q000627:therapeutic use*; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D011372:Progestins