Role of surgeons in clinical trials for thyroid cancer.
Properly performed clinical trials provide a foundation for evidence-based medical practice. The surgeon plays a central role in the management of patients with malignant solid tumors, including thyroid cancer, because operative extirpation of the malignancy is the essential first step in effective therapy. This article discusses the role of the surgeon in the clinical research of thyroid cancer and also reviews the important clinical trials that have influenced the treatment of patients with thyroid cancer. Recent discoveries defining the genetic mutations underlying the various types of thyroid cancers have led to the development of targeted therapies. These chemical compounds, which are now being evaluated in clinical trials, hold great promise for the treatment of patients with locally advanced and distant metastatic disease. The surgical investigator also plays an important role in procuring tumor tissue from patients in clinical trials. The molecular analysis of these tissues is of critical importance in selecting specific therapies and predicting patient response and prognosis.
You
Y Nancy
YN
Department of Surgery, Mayo Clinic, Rochester, Minnesota 55902, USA.
Wells
Samuel A
SA
D002986:Clinical Trials as Topic; D019317:Evidence-Based Medicine; D006801:Humans; D008967:Molecular Biology; D009364:Neoplasm Recurrence, Local; D010819:Physician's Role; D011237:Predictive Value of Tests; D011379:Prognosis; D013964:Thyroid Neoplasms / Q000235:genetics / Q000601:surgery*