A unique case of IgD-only splenic marginal-zone lymphoma with mutated immunoglobulin genes: ontogenetic implications.
Splenic marginal zone lymphoma (SMZL) is a rare indolent lymphoma subtype which accounts for less than 1% of all non-Hodgkin's lymphomas. We here report a unique case of IgD-only SMZL with mutated immunoglobulin variable region genes and discuss possible ontogenetic derivation.
Papadaki
Theodora
T
Hemopathology Department, Evangelismos Hospital, Athens, Greece.
Stamatopoulos
Kostas
K
Mavrommatis
Theodore
T
Anagnostopoulos
Achilles
A
Anagnostou
Dimitra
D
D000368:Aged; D005260:Female; D005803:Genes, Immunoglobulin; D006801:Humans; D007072:Immunoglobulin D / Q000378:metabolism*; D007135:Immunoglobulin Variable Region / Q000235:genetics*; D007150:Immunohistochemistry; D018442:Lymphoma, B-Cell, Marginal Zone; D009154:Mutation; D013160:Splenic Neoplasms / Q000235:genetics*
D007072:Immunoglobulin D; D007135:Immunoglobulin Variable Region