title: Mast-cell sarcoma of the tibia.
abstract: The mast-cell sarcoma of a bone is described here for the first time. The tumour presented in a 4-year-old boy, with pain, oedema and deformation of his right lower leg. Radiological findings revealed a destructive tumourous mass. Histopathological examination showed the tumour to be composed of large, atypical cells, with hyperchromatic oval and polygonal nuclei. The cytoplasm around them was eosinophilic with many basophilic and toluidine-blue-positive granules. These atypical mast cells were positive for chloroacetate esterase, c-kit, tryptase and negative for myeloperoxidase. The primary disease quickly progressed to mast-cell leukaemia, and despite intensive chemotherapy the patient died 18 months after first symptoms.
authors.affiliation: Institute of Pathology, Medical School, University of Zagreb, Zagreb, Croatia.
authors.forename: Luka
authors.initials: L
authors.lastname: Brcić
authors.forename: Lovorka Batelja
authors.initials: LB
authors.lastname: Vuletić
authors.forename: Jasminka
authors.initials: J
authors.lastname: Stepan
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Bonevski
authors.forename: Gordana
authors.initials: G
authors.lastname: Jakovljević
authors.forename: Slavko
authors.initials: S
authors.lastname: Gasparov
authors.forename: Ksenija
authors.initials: K
authors.lastname: Marjanović
authors.forename: Sven
authors.initials: S
authors.lastname: Seiwerth
mesh_terms: D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D002675:Child, Preschool; D018450:Disease Progression; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D012515:Mast-Cell Sarcoma / Q000000981:diagnostic imaging / Q000473:pathology*; D013977:Tibia; D014057:Tomography, X-Ray Computed