[Serum and sputum eosinophil cationic protein levels and clinical status in cystic fibrosis patients].
Recent studies have emphasied the role of eosinophils and it's metabolites in the pathogenesis of lung disease in cystic fibrosis. This study was designed to assess the relationship between serum and sputum ECP levels and clinical status of cystic fibrosis patients.


METHODS
30 patients, aged 6-30 with moderate cystic fibrosis were recruited. Spirometry, weight and high, and Shwachman-Kulczycki score were measured, and serum and sputum samples were obtained for measurements of the eosinophil cationic protein (ECP).


RESULTS
We observed significant inverse correlation between sputum ECP levels and BMI (p<0.001) and FEV1 (p<0.001), and not significant inverse correlation between sputum ECP levels Shwachman-Kulczycki score (p=0.057). There was no signifi cant correlation between sputum ECP levels and FEF25/75% and between serum ECP levels and measured clinical parameters.


CONCLUSIONS
Results of this study suggest influence of eosinophil inflammation in respiratory tract on clinical status of CF patients.
Korzeniewska
Aleksandra
A
Oddział Kliniczny Interny Dzieciecej i Alergologii III Katedry Pediatrii Wojewódzki Szpital Specjalistyczny im. M. Kopernika w Łodzi, Poland. alergol@kopernik.lodz.pl
Sołoniewicz
Anna
A
Stelmach
Piotr
P
Sobocińska
Agnieszka
A
Stelmach
Iwona
I
D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000032:analysis; D015992:Body Mass Index; D002648:Child; D003550:Cystic Fibrosis / Q000097:blood / Q000378:metabolism*; D047150:Eosinophil Cationic Protein / Q000032:analysis* / Q000097:blood; D004804:Eosinophils / Q000166:cytology; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D044967:Serum / Q000737:chemistry; D013048:Specimen Handling / Q000379:methods; D013183:Sputum / Q000737:chemistry* / Q000166:cytology; D014797:Vital Capacity
D015415:Biomarkers; D047150:Eosinophil Cationic Protein