title: Expeditious access to unprotected racemic pyroglutamic acids.
abstract: A series of biologically intriguing pyroglutamic acids were synthesized in racemic form by employing indole-isonitrile and ammonium acetate in the Ugi 4-center-3-component reaction of gamma-ketoacids.
authors.affiliation: Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive Mail Code 0343, La Jolla, California 92093-0343, USA.
authors.forename: Jerry
authors.initials: J
authors.lastname: Isaacson
authors.forename: Cynthia B
authors.initials: CB
authors.lastname: Gilley
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Kobayashi
mesh_terms: D000588:Amines / Q000737:chemistry; D000813:Anilides / Q000737:chemistry; D007211:Indoles / Q000737:chemistry; D008745:Methylation; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry; D011761:Pyrrolidonecarboxylic Acid / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000588:Amines; D000813:Anilides; D007211:Indoles; D009570:Nitriles; D011761:Pyrrolidonecarboxylic Acid