title: Prednisolone concentration in the cochlea of patients with perilymph fistula.
abstract: After iv administration of 200 mg prednisolone in patients with perilymph fistula, concentrations of the drug in the cochlea were determined. A specially adapted LC method was used for analysis. Mean concentrations of prednisolone in the perilymphe reached 95 ng/ml after 15-25 min, and 338 ng/ml after 30-45 min. The values reached 8 and 41% of the corresponding serum concentrations, respectively.
authors.affiliation: Institut für klinische Pharmakologie, Med. Fakultät, TU-Dresden, Germany. reinhard.oertel@tu-dresden.de
authors.forename: R
authors.initials: R
authors.lastname: Oertel
authors.forename: W
authors.initials: W
authors.lastname: Kirch
authors.forename: E
authors.initials: E
authors.lastname: Klemm
mesh_terms: D000893:Anti-Inflammatory Agents / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D002851:Chromatography, High Pressure Liquid; D003051:Cochlea / Q000378:metabolism*; D015834:Cochlear Diseases / Q000378:metabolism*; D005402:Fistula / Q000378:metabolism; D006801:Humans; D007275:Injections, Intravenous; D010498:Perilymph / Q000378:metabolism*; D011239:Prednisolone / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D012015:Reference Standards; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D000893:Anti-Inflammatory Agents; D011239:Prednisolone