title: Antimalarial activity of sera from subjects taking HIV protease inhibitors.
abstract: Synergy between HIV and malaria is being increasingly recognized. We examined the antimalarial activity of sera from subjects receiving chloroquine, no drugs or HAART. Sera from subjects taking ritonavir-boosted saquinavir or lopinavir significantly inhibited parasite growth (median of 55 and 69% inhibition, respectively). These results indicate that patients on protease inhibitors may be afforded some protection from malaria. The clinical relevance of these observations will require confirmation in controlled studies in malaria-endemic regions.
authors.affiliation: Department of Infectious Diseases, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.
authors.forename: Andrew M
authors.initials: AM
authors.lastname: Redmond
authors.forename: Tina
authors.initials: T
authors.lastname: Skinner-Adams
authors.forename: Katherine T
authors.initials: KT
authors.lastname: Andrews
authors.forename: Donald L
authors.initials: DL
authors.lastname: Gardiner
authors.forename: John
authors.initials: J
authors.lastname: Ray
authors.forename: Mark
authors.initials: M
authors.lastname: Kelly
authors.forename: James S
authors.initials: JS
authors.lastname: McCarthy
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active / Q000379:methods; D002738:Chloroquine / Q000627:therapeutic use; D004357:Drug Synergism; D015658:HIV Infections / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D017320:HIV Protease Inhibitors / Q000627:therapeutic use*; D006801:Humans; D061466:Lopinavir; D016778:Malaria, Falciparum / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D010963:Plasmodium falciparum / Q000187:drug effects / Q000254:growth & development; D011744:Pyrimidinones / Q000627:therapeutic use; D018894:Reverse Transcriptase Inhibitors / Q000627:therapeutic use; D019438:Ritonavir / Q000627:therapeutic use; D019258:Saquinavir / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D000962:Antimalarials; D017320:HIV Protease Inhibitors; D011744:Pyrimidinones; D018894:Reverse Transcriptase Inhibitors; D061466:Lopinavir; D002738:Chloroquine; D019258:Saquinavir; D019438:Ritonavir