Nearly identical strains of human herpesvirus 8 in couples discordant for Kaposi's sarcoma.
Transmission of human herpesvirus 8 (HHV-8) may occur through various routes including breastfeeding and sexual intercourse. We attempted to detect HHV-8 infection in nine HIV-positive couples discordant for Kaposi's sarcoma who maintained a monogamous sexual relationship for at least one year. By quantitative real-time polymerase chain reaction and HHV-8 genotyping we provide strong evidence for the sexual transmission of HHV-8 in this unique cohort.
Kouri
Vivian
V
Instituto de Medicina Tropical Pedro Kouri, Ciudad de La Habana, Cuba.
Marini
Alessandra
A
Nambiar
Sandeep
S
Rodriguez
Maria E
ME
Capo
Virginia
V
Resik
Sonia
S
Mantecon
Beatriz
B
Martinez
Ariel
A
Köhler-Hansner
Karin J
KJ
Hengge
Ulrich R
UR
D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D015331:Cohort Studies; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D005838:Genotype; D006679:HIV Seropositivity / Q000150:complications / Q000188:drug therapy / Q000821:virology*; D019288:Herpesvirus 8, Human / Q000302:isolation & purification*; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000821:virology; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction / Q000379:methods; D012514:Sarcoma, Kaposi / Q000150:complications / Q000821:virology*; D017386:Sequence Homology, Amino Acid; D012725:Sexual Behavior
D004279:DNA, Viral