title: Future aspects of bioprocess monitoring.
abstract: Nature has the impressive ability to efficiently and precisely control biological processes by applying highly evolved principles and using minimal space and relatively simple building blocks. The challenge is to transfer these principles into technically applicable and precise analytical systems that can be used for many applications. This article summarizes some of the new approaches in sensor technology and control strategies for different bioprocesses such as fermentations, biotransformations, and downstream processes. It focuses on bio- and chemosensors, optical sensors, DNA and protein chip technology, software sensors, and modern aspects of data evaluation for improved process monitoring and control.
authors.affiliation: Universität Hohenheim, Process Analysis, Garbenstrasse 25, 70599 Stuttgart, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Becker
authors.forename: Bernd
authors.initials: B
authors.lastname: Hitzmann
authors.forename: K
authors.initials: K
authors.lastname: Muffler
authors.forename: Ralf
authors.initials: R
authors.lastname: Pörtner
authors.forename: Kenneth F
authors.initials: KF
authors.lastname: Reardon
authors.forename: Frank
authors.initials: F
authors.lastname: Stahl
authors.forename: Roland
authors.initials: R
authors.lastname: Ulber
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation / Q000379:methods*; D001709:Biotechnology / Q000295:instrumentation / Q000379:methods* / Q000639:trends; D017022:Flow Injection Analysis / Q000295:instrumentation / Q000379:methods; D020411:Oligonucleotide Array Sequence Analysis / Q000295:instrumentation / Q000379:methods; D040081:Protein Array Analysis / Q000295:instrumentation / Q000379:methods; D013050:Spectrometry, Fluorescence / Q000295:instrumentation / Q000379:methods; D019265:Spectroscopy, Near-Infrared / Q000295:instrumentation / Q000379:methods; D013059:Spectrum Analysis, Raman / Q000295:instrumentation / Q000379:methods