A facile approach to the synthesis of chiral 2-substituted benzofurans.
An effective route to chiral optically active 2-substituted benzofurans directly from carboxylic acids is reported. This procedure, which allows the preparation of alpha-alkyl-2-benzofuranmethanamines from N-protected alpha-amino acids without sensible racemization phenomena, proceeds in good yields under mild conditions with the help of microwave irradiation.
De Luca
Lidia
L
Dipartimento di Chimica, Università degli Studi di Sassari, via Vienna 2, I-07100 Sassari, Italy.
Giacomelli
Giampaolo
G
Nieddu
Giammario
G
D000478:Alkylation; D001572:Benzofurans / Q000138:chemical synthesis / Q000737:chemistry*; D002264:Carboxylic Acids / Q000737:chemistry; D005663:Furans / Q000737:chemistry*; D008872:Microwaves; D015394:Molecular Structure; D013237:Stereoisomerism
D001572:Benzofurans; D002264:Carboxylic Acids; D005663:Furans