Inhibitory activities of three classes of acyclic nucleoside phosphonates against murine polyomavirus and primate simian virus 40 strains.
Murine polyomavirus and simian virus 40 were used to evaluate the potencies of the compounds of three classes of acyclic nucleoside phosphonates: (i) the original HPMP (3-hydroxy-2-phosphonomethoxypropyl) and PME (2-phosphonomethoxyethyl) derivatives, (ii) the 6-[2-(phosphonomethoxy)alkoxy]-2,4-diaminopyrimidine (DAPy) derivatives, and (iii) a new class of HPMP derivatives containing a 5-azacytosine moiety. The last class showed the highest activities and selectivities against both polyomaviruses.
Lebeau
Ilya
I
Rega Institute for Medical Research, K.U. Leuven, Minderbroedersstraat 10, Leuven, Belgium.
Andrei
Graciela
G
Krecmerová
Marcela
M
De Clercq
Erik
E
Holy
Antonin
A
Snoeck
Robert
R
D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry / Q000145:classification / Q000494:pharmacology* / Q000633:toxicity; D002460:Cell Line; D000077404:Cidofovir; D003596:Cytosine / Q000031:analogs & derivatives / Q000494:pharmacology / Q000633:toxicity; D051379:Mice; D008826:Microbial Sensitivity Tests; D009705:Nucleosides / Q000737:chemistry / Q000145:classification / Q000494:pharmacology* / Q000633:toxicity; D063065:Organophosphonates / Q000737:chemistry / Q000145:classification / Q000494:pharmacology* / Q000633:toxicity; D011120:Polyomavirus / Q000187:drug effects*; D011741:Pyrimidine Nucleosides / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D011743:Pyrimidines / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D013539:Simian virus 40 / Q000187:drug effects*
D000998:Antiviral Agents; D009705:Nucleosides; D063065:Organophosphonates; D011741:Pyrimidine Nucleosides; D011743:Pyrimidines; C017205:2,4-diaminopyrimidine; D003596:Cytosine; D000077404:Cidofovir