Too much to count on: impaired very small numbers in corticobasal degeneration.
Patients with corticobasal degeneration (CBD) have calculation impairments. This study examined whether impaired number knowledge depends on verbal mediation. We focused particularly on knowledge of very small numbers, where there is a precise relationship between a cardinality and its number concept, but little hypothesized role for verbal mediation. We evaluated accuracy and reaction time (RT) for matching dot arrays and Arabic numerals involving smaller (2-4) and larger (5-9) cardinalities in non-aphasic patients with CBD (n=16), frontotemporal dementia (FTD; n=23), and healthy controls (n=15). CBD were less accurate and slowed at judging smaller Arabic numeral-dot array stimuli compared to FTD patients and controls. Moreover, only CBD showed longer RTs judging successively larger number-dot array pairs among the smaller cardinalities. Difficulty judging very small numbers is impaired in CBD, suggesting degraded representation of precise number knowledge that does not depend on language functioning.
Halpern
Casey
C
Department of Neurology, University of Pennsylvania Medical Center, 3400 Spruce Street, Philadelphia, PA 19104-4283, USA.
Clark
Robin
R
Moore
Peachie
P
Cross
Katy
K
Grossman
Murray
M
D000368:Aged; D001284:Atrophy; D001479:Basal Ganglia / Q000473:pathology / Q000502:physiology / Q000503:physiopathology; D016022:Case-Control Studies; D002540:Cerebral Cortex / Q000473:pathology / Q000502:physiology / Q000503:physiopathology; D003072:Cognition Disorders / Q000209:etiology* / Q000503:physiopathology; D003704:Dementia / Q000150:complications / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007806:Language Disorders / Q000209:etiology* / Q000503:physiopathology; D008297:Male; D016555:Matched-Pair Analysis; D008433:Mathematics; D008875:Middle Aged; D019636:Neurodegenerative Diseases / Q000150:complications / Q000473:pathology / Q000503:physiopathology*; D011930:Reaction Time / Q000502:physiology; D012660:Semantics