Waiting to inhale: HIF-1 modulates aerobic respiration.
The hypoxia-inducible factor HIF-1 is known to promote anaerobic respiration during low oxygen conditions (hypoxia). In this issue, Fukuda et al. (2007) expand the range of HIF-1's functions by showing that it modulates aerobic respiration as well.
Boutin
Adam T
AT
Molecular Biology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA.
Johnson
Randall S
RS
D000332:Aerobiosis; D000818:Animals; D015687:Cell Hypoxia; D019069:Cell Respiration; D003576:Electron Transport Complex IV / Q000378:metabolism*; D006801:Humans; D051793:Hypoxia-Inducible Factor 1 / Q000378:metabolism*; D008928:Mitochondria / Q000378:metabolism; D015003:Yeasts / Q000378:metabolism
D051793:Hypoxia-Inducible Factor 1; D003576:Electron Transport Complex IV