Design of chiral organocatalysts for practical asymmetric synthesis of amino acid derivatives.
A series of structurally rigid, chiral quaternary ammonium salts and several chiral sec-amine catalysts derived from commercially available (R)- or (S)-binaphthol have been designed as new C(2)-symmetric chiral phase-transfer catalysts and chiral bifunctional amino-catalysts. These chiral organocatalysts have been successfully applied to the highly practical asymmetric synthesis of various amino acid derivatives.
Maruoka
Keiji
K
Department of Chemistry, Graduate School of Science, Kyoto University, Kyoto 606-8502, Japan. maruoka@kuchem.kyoto-u.ac.jp
Ooi
Takashi
T
Kano
Taichi
T
D000596:Amino Acids / Q000138:chemical synthesis*; D002384:Catalysis; D015394:Molecular Structure; D000644:Quaternary Ammonium Compounds / Q000737:chemistry*; D013237:Stereoisomerism
D000596:Amino Acids; D000644:Quaternary Ammonium Compounds