Anti-inflammatory actions of quinapril.
OBJECTIVE
The role of angiotensin II (Ang-II) in inflammation and the mechanisms through which it exerts this role are explored. Signaling through angiotensin stimulation of inflammatory cells often amplifies inflammation. Formation of Ang-II from tissue angiotensin-converting enzyme (ACE) has been shown to be of greater importance in the development and progression of inflammatory diseases than plasma ACE.


CONCLUSIONS
Quinapril, which is a potent and selective inhibitor of both plasma and tissue ACE, has demonstrated anti-inflammatory properties in many disease states such as atherosclerosis, nephritis, scleroderma, diabetes and arthritis, and, thus, offers new therapeutic possibilities for disease treatment.
Egido
Jesus
J
Vascular and Renal Laboratory Fundacion Jimenez Díaz, Autonoma University Madrid, Avda Reyes Católicos 2, Madrid, Spain. jegido@fjd.es
Ruiz-Ortega
Marta
M
D000804:Angiotensin II / Q000037:antagonists & inhibitors / Q000378:metabolism; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D007249:Inflammation / Q000378:metabolism / Q000517:prevention & control; D008954:Models, Biological; D000077583:Quinapril; D044005:Tetrahydroisoquinolines / Q000494:pharmacology / Q000627:therapeutic use*
D000806:Angiotensin-Converting Enzyme Inhibitors; D000893:Anti-Inflammatory Agents; D044005:Tetrahydroisoquinolines; D000804:Angiotensin II; D000077583:Quinapril