title: MR spectroscopy in patients with intracranial meningiomas.
abstract: With magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS), we tried to get more pre-operative information in patients with suspicious meningioma concerning the histologic diagnosis especially regarding WHO Grades I and II meningiomas. Apart from the known spectra and metabolites such as choline, creatine and N-acetyl-aspartate (NAA), recent publications have shown that lactate is often found in necrotic tumor tissue. Within a 2 year period, 39 patients with an intracranial meningioma were studied with MRS. In 62.5% of histologic atypical meningiomas (WHO Grade II), a lactate peak could be demonstrated in the pre-operative MRS. Interestingly, also patients with multiple meningiomas show different spectra of their tumors.
authors.affiliation: Department of Neurosurgery, University of Schleswig Holstein, Campus Kiel, Kiel, Germany. buhlr@nch.uni-kiel.de
authors.forename: R
authors.initials: R
authors.lastname: Buhl
authors.forename: A
authors.initials: A
authors.lastname: Nabavi
authors.forename: S
authors.initials: S
authors.lastname: Wolff
authors.forename: H H
authors.initials: HH
authors.lastname: Hugo
authors.forename: K
authors.initials: K
authors.lastname: Alfke
authors.forename: O
authors.initials: O
authors.lastname: Jansen
authors.forename: H M
authors.initials: HM
authors.lastname: Mehdorn
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis / Q000378:metabolism; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D019344:Lactic Acid / Q000032:analysis / Q000378:metabolism; D008279:Magnetic Resonance Imaging / Q000379:methods; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D008577:Meningeal Neoplasms / Q000145:classification / Q000175:diagnosis* / Q000378:metabolism; D008578:Meninges / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology; D008579:Meningioma / Q000145:classification / Q000175:diagnosis* / Q000378:metabolism; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000175:diagnosis; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis; D011237:Predictive Value of Tests; D014057:Tomography, X-Ray Computed
chemical_list: D014408:Biomarkers, Tumor; D019344:Lactic Acid