title: [A case of gastroesophageal reflux disease with marked eosinophilia].
abstract: A 73-year-old woman without a history of allergic diseases visited our hospital complaining of sore throat and nocturnal cough. Blood tests showed marked eosinophilia (18000/mm(3);WBC 21900/mm(3), Eos 82.0%) with normal serum levels of C-reactive protein, non-specific and various allergen-specific IgE. Stool tests for protozoa or helminthic ova were negative. Chest X-ray films showed no pulmonary abnormalities. Endoscopic and histological examinations revealed reflux esophagitis (grade C according to the Los Angeles Classification System) with hiatal hernia with inflammatory infiltrates including eosinophils within the esophageal mucosa. A computed tomography showed the thickening of the esophageal wall. An administration of lansoprazole improved reflux esophagitis and also eosinophilia, and an alteration to famotidine caused heartburn with an increase in eosinophils. A re-alteration to omeprazole relieved the symptom and decreased eosinophils. It was shown that gastroesophageal reflux disease was one of the possible causes of eosinophilia.
authors.affiliation: Department of Internal Medicine, Hyogo Prefectural Nishinomiya Hospital.
authors.forename: Rika
authors.initials: R
authors.lastname: Miyoshi
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Yasunaga
authors.forename: Takashi
authors.initials: T
authors.lastname: Kizu
authors.forename: Takuya
authors.initials: T
authors.lastname: Inoue
authors.forename: Chie
authors.initials: C
authors.lastname: Watanabe
authors.forename: Yumi
authors.initials: Y
authors.lastname: Matsumoto
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Katata
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Inui
authors.forename: Takashi
authors.initials: T
authors.lastname: Kohro
authors.forename: Masahiro
authors.initials: M
authors.lastname: Nishikawa
mesh_terms: D053799:2-Pyridinylmethylsulfinylbenzimidazoles / Q000008:administration & dosage; D000368:Aged; D004802:Eosinophilia / Q000209:etiology*; D004942:Esophagitis, Peptic / Q000150:complications / Q000188:drug therapy; D005260:Female; D005764:Gastroesophageal Reflux / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D064747:Lansoprazole; D009853:Omeprazole / Q000008:administration & dosage
chemical_list: D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D064747:Lansoprazole; D009853:Omeprazole