title: Sirolimus-eluting, bioabsorbable polymer-coated constant stent (Cura) in acute ST-elevation myocardial infarction: a clinical and angiographic study (CURAMI Registry).
abstract: BACKGROUND
  There are safety concerns over the current polymer-based drug-eluting stents (DES) on the possible delayed healing process and adverse reactions to the polymer when drug elution is completed. Cura (Orbus Neich) is a sirolimus-eluting, bioabsorbable, polymer-coated constant stent.
  
  
  METHODS
  From March 1 to June 30, 2005, Cura stent implantation was instituted as the default strategy for percutaneous coronary intervention in 49 consecutive ST-Elevation Myocardial Infarction (STEMI) patients (male 86%; average age 55 +/- 10 years; diabetes 31%).
  
  
  RESULTS
  The angiographic success rate was 100%. In-hospital adverse events consisted of 1 in-hospital death (2% heart failure). A total of 27 patients (56%) underwent 8-month angiographic follow up. Binary restenosis occurred in 6 patients (22%), and late loss was 0.74 +/- 0.89 mm. At 9-month follow up, a total of 5 patients had 6 major adverse events (1 death, 1 reinfarction, and 4 target lesion revascularizations). There was no incidence of stent thrombosis.
  
  
  CONCLUSIONS
  Cura stent implantation appears to be feasible and safe in the treatment of STEMI. However, the binary restenosis rate and late loss at angiographic follow up were similar to that of bare-metal stents, and therefore compare unfavorably with other proven benchmark DES.
authors.affiliation: Heart Institute, National University Hospital, Singapore. leerch@hotmail.com
authors.forename: Chi-Hang
authors.initials: CH
authors.lastname: Lee
authors.forename: Jimmy
authors.initials: J
authors.lastname: Lim
authors.forename: Adrian
authors.initials: A
authors.lastname: Low
authors.forename: Xiao-Ling
authors.initials: XL
authors.lastname: Zhang
authors.forename: Than-Than
authors.initials: TT
authors.lastname: Kyaing
authors.forename: Mark Y
authors.initials: MY
authors.lastname: Chan
authors.forename: Hwee-Bee
authors.initials: HB
authors.lastname: Wong
authors.forename: Yean-Teng
authors.initials: YT
authors.lastname: Lim
authors.forename: Huay-Cheem
authors.initials: HC
authors.lastname: Tan
mesh_terms: D000368:Aged; D020099:Coated Materials, Biocompatible; D017023:Coronary Angiography; D023903:Coronary Restenosis / Q000517:prevention & control; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging / Q000401:mortality / Q000628:therapy*; D011108:Polymers; D011474:Prosthesis Design; D012042:Registries; D015607:Stents
chemical_list: D020099:Coated Materials, Biocompatible; D011108:Polymers