Primary T-cell lymphoma of the thyroid gland with chemokine receptors of Th1 phenotype complicating autoimmune thyroiditis.
Lymphoma of the thyroid is almost exclusively derived from B cells of mucosa-associated lymphoid tissue (MALT), and frequently co-exist with autoimmune thyroiditis in which most infiltrating cells are of Th1 cell origin. We present here two rare cases of peripheral T-cell lymphoma (PTCL) based on chronic thyroiditis with the phenotype CD3+, CD4+, CD8-, TCR+. Furthermore, lymphoma cells in both cases were CXCR3+, CCR5+ and ST2(L)-, suggesting a Th1 cell origin. Eight of 11 cases of PTCL of the thyroid in the literature, including our cases, were associated with thyroiditis. Except for one tumor of T-cell type, all of the five lymphomas analyzed for CD4 expression were positive for the antigen. Among them, both those examined for chemokine receptors were phenotypically of Th1-cell origin with a background of thyroiditis, suggesting that Th1 activation induced by chronic inflammation could lead to PTCL of themselves as well as MALT-lymphoma of B cells.
Koida
Satoshi
S
Department of Hematology, Molecular Medicine Unit, Atomic Bomb Disease Institute, Nagasaki 852-8523 Japan.
Tsukasaki
Kunihiro
K
Tsuchiya
Takeshi
T
Harasawa
Hitomi
H
Fukushima
Takuya
T
Yamada
Yasuaki
Y
Ohshima
Koichi
K
Kamihira
Shimeru
S
Kikuchi
Masahiro
M
Tomonaga
Masao
M
D000368:Aged; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis; D000951:Antigens, Neoplasm / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis; D015704:CD4 Antigens / Q000032:analysis; D002471:Cell Transformation, Neoplastic; D050031:Hashimoto Disease / Q000150:complications; D006801:Humans; D016130:Immunophenotyping; D016411:Lymphoma, T-Cell, Peripheral / Q000737:chemistry / Q000150:complications* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000032:analysis*; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000235:genetics; D019707:Receptors, Chemokine / Q000032:analysis*; D018417:Th1 Cells / Q000473:pathology*; D013964:Thyroid Neoplasms / Q000737:chemistry / Q000150:complications* / Q000473:pathology; D013967:Thyroiditis, Autoimmune / Q000150:complications*
D000945:Antigens, Differentiation, T-Lymphocyte; D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D015704:CD4 Antigens; D009363:Neoplasm Proteins; D016693:Receptors, Antigen, T-Cell, alpha-beta; D019707:Receptors, Chemokine