title: Identification of a new protein in the centrosome-like "atractophore" of Trichomonas vaginalis.
abstract: The human parasite Trichomonas vaginalis has specific structural bodies, atractophores, associated at one end to the kinetosomes and at the other to the spindle during division. A monoclonal antibody specific for a component of this structure was obtained. It recognizes a protein with a predicted molecular mass of 477 kDa. Sequence analysis of this protein shows that P477 belongs to the family of large coiled-coil proteins, sharing a highly versatile protein folding motif adaptable to many biological functions. P477-might act as an anchor to localize cellular activities and components to the golgi centrosomal region. It may represent a new class of structural proteins, since similar proteins were found in many protozoans.
authors.affiliation: Biologie des Protistes, UMR CNRS6023, Université Blaise Pascal, Les Cézeaux, 63177 Aubière, France. genevieve.bricheux@univ-bpclermont.fr
authors.forename: Geneviève
authors.initials: G
authors.lastname: Bricheux
authors.forename: Gérard
authors.initials: G
authors.lastname: Coffe
authors.forename: Guy
authors.initials: G
authors.lastname: Brugerolle
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002455:Cell Division; D018385:Centrosome / Q000378:metabolism* / Q000648:ultrastructure*; D005455:Fluorescent Antibody Technique; D015723:Gene Library; D006801:Humans; D008969:Molecular Sequence Data; D015800:Protozoan Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D017422:Sequence Analysis, DNA; D014246:Trichomonas vaginalis / Q000166:cytology / Q000235:genetics / Q000378:metabolism / Q000648:ultrastructure*
chemical_list: D015800:Protozoan Proteins