title: [Late-onset familial amyloid polyneuropathy in the Safor (Valencia) area: four case reports].
abstract: Four cases of late onset familial amyloid polyneuropathy diagnosed in relatively advanced ages and within 3 families of our area where the disease had never been described are presented. The possible origin of the mutation and need to consider this diagnosis even when there is no known family background or when the age of presentation is late are commented. The nerve biopsy does not always show the deposits as these are patchy and DNA studies or detection of abnormal TTR in serum are necessary for the diagnosis.
authors.affiliation: Servicio de Medicina Interna, Hospital Francisco de Borja, Gandía, Valencia, Spain. Tornero_car@gva.es
authors.forename: C
authors.initials: C
authors.lastname: Tornero Estébanez
authors.forename: C
authors.initials: C
authors.lastname: Soriano Soriano
authors.forename: A
authors.initials: A
authors.lastname: Giménez Escrich
authors.forename: S
authors.initials: S
authors.lastname: Rull Segura
mesh_terms: D000367:Age Factors; D000368:Aged; D028227:Amyloid Neuropathies, Familial / Q000175:diagnosis / Q000235:genetics / Q000401:mortality; D018450:Disease Progression; D005260:Female; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D013030:Spain; D013997:Time Factors