title: Palladium-catalyzed annulation of aryl heterocycles with strained alkenes.
abstract: [reaction: see text] An annulation reaction proceeding by the intermolecular addition of an arylpalladium(II) halide across a strained alkene, followed by an intramolecular C-H functionalization of a pendant heterocycle is described. A variety of polycyclic heterocycles have been prepared from readily accessible haloaryl heterocycles by annulation with a range of strained alkene partners.
authors.affiliation: Davenport Laboratories, Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario, Canada M5S 3H6.
authors.forename: David G
authors.initials: DG
authors.lastname: Hulcoop
authors.forename: Mark
authors.initials: M
authors.lastname: Lautens
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D001965:Bromides / Q000737:chemistry; D002384:Catalysis; D047028:Macrocyclic Compounds / Q000737:chemistry*; D009636:Norbornanes / Q000737:chemistry; D010165:Palladium / Q000737:chemistry*; D011758:Pyrroles / Q000737:chemistry
chemical_list: D000475:Alkenes; D001965:Bromides; D047028:Macrocyclic Compounds; D009636:Norbornanes; D011758:Pyrroles; D010165:Palladium