title: [Tobacco use and plasma lipid-lipoprotein profile in adolescents].
abstract: OBJECTIVE
  To analyze the impact of tobacco use on plasma lipid lipoprotein profile in representative sample of adolescents.
  
  
  METHODS
  A sample of 452 subjects (246 girls and 206 boys) 15 to 18 years old were included in the study. Each participant completed a structured and self-administered questionnaire concerning tobacco use. Plasma lipid-lipoprotein concentrations were measured by standard procedures. Differences between mean values were evaluated by analysis of covariance, controlling for saturated fat and cholesterol intake. Odds ratio was used to estimate the relative risk of the smokers being classified with an undesirable level of a plasma lipidlipoprotein parameter.
  
  
  RESULTS
  The proportion of smokers was 20.9% for boys and 15.4% for girls. The average consumption of cigarettes per day was 9.2+/-4.7 for boys and 5.6+/-3.1 for girls. When compared with non-smokers, boy and girl smokers showed a significantly higher serum levels of total cholesterol, LDL-cholesterol, triglycerides and apolipoprotein B100, and significantly lower serum levels of HDL-cholesterol. Adolescent smokers tended to show a two-fold higher risk of altered lipid-lipoprotein levels than non-smokers.
  
  
  CONCLUSIONS
  The present data could imply that intervention promoting a healthy lifestyle, including non smoking, should start at an early age to prevent or delay development of atherosclerotic lesions and ultimately to minimize the appearance of premature coronary heart disease in adults.
authors.affiliation: Universidade Estadual de Londrina, Paraná, Brazil. darta@sercomtel.com.br
authors.forename: Dartagnan Pinto
authors.initials: DP
authors.lastname: Guedes
authors.forename: Joana Elisabete Ribeiro Pinto
authors.initials: JE
authors.lastname: Guedes
authors.forename: Décio Sabbatini
authors.initials: DS
authors.lastname: Barbosa
authors.forename: Jair Aparecido
authors.initials: JA
authors.lastname: de Oliveira
mesh_terms: D000293:Adolescent; D001053:Apolipoproteins / Q000097:blood; D001938:Brazil; D002791:Cholesterol, Dietary / Q000008:administration & dosage / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D004812:Epidemiologic Methods; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D012907:Smoking / Q000009:adverse effects / Q000097:blood*; D012959:Socioeconomic Factors; D014280:Triglycerides / Q000097:blood; D014026:Nicotiana
chemical_list: D001053:Apolipoproteins; D002791:Cholesterol, Dietary; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008055:Lipids; D008074:Lipoproteins; D014280:Triglycerides