title: Refining indications for the use of mitomycin C using a randomized controlled trial with an animal model.
abstract: OBJECTIVE
  To evaluate the effect of mitomycin on the repair of acquired subglottic stenosis and to define the optimal concentration of mitomycin that would minimize restenosis after repair.
  
  
  METHODS
  A randomized prospective model was used in which 20 ferrets (Mustela putorius furo) underwent simulated intubation injury that was then treated with CO2 laser lysis.
  
  
  RESULTS
  Comparison of cross-sectional airway areas, after stenosis repair, showed no significant differences between control and mitomycin treatment groups. Comparison of histologic scores for both inflammation and mucosalization yielded no difference between control and treatment animals.
  
  
  CONCLUSIONS
  Mitomycin C appeared to have no benefit when placed after repair of an acquired stenosis.
  
  
  CONCLUSIONS
  This study closely models the injury experienced by children with acquired subglottic stenosis. These data provide clear evidence that mitomycin is limited in its effect on established wounds and help further define its role as an adjuvant for surgery in the aerodigestive tract.
authors.affiliation: Tripler Army Medical Center, Honolulu, HI 96859, USA. jshvidler@yahoo.com
authors.forename: Joseph
authors.initials: J
authors.lastname: Shvidler
authors.forename: Nici E
authors.initials: NE
authors.lastname: Bothwell
authors.forename: Benjamin
authors.initials: B
authors.lastname: Cable
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005289:Ferrets; D007829:Laryngostenosis / Q000188:drug therapy* / Q000517:prevention & control*; D016685:Mitomycin / Q000008:administration & dosage / Q000627:therapeutic use*; D016032:Randomized Controlled Trials as Topic; D012008:Recurrence
chemical_list: D016685:Mitomycin