Diminished potential for B-lymphoid differentiation after murine leukemia virus infection in vivo and in EML hematopoietic progenitor cells.
Infection with a recombinant murine-feline gammaretrovirus, MoFe2, or with the parent virus, Moloney murine leukemia virus, caused significant reduction in B-lymphoid differentiation of bone marrow at 2 to 8 weeks postinfection. The suppression was selective, in that myeloid potential was significantly increased by infection. Analysis of cell surface markers and immunoglobulin H gene rearrangements in an in vitro model demonstrated normal B-lymphoid differentiation after infection but significantly reduced viability of differentiating cells. This reduction in viability may confer a selective advantage on undifferentiated lymphoid progenitors in the bone marrow of gammaretrovirus-infected animals and thereby contribute to the establishment of a premalignant state.
Finstad
Samantha L
SL
Department of Microbiology and Immunology, Tulane University School of Medicine, 1430 Tulane Avenue SL-38, New Orleans, LA 70112, USA.
Rosenberg
Naomi
N
Levy
Laura S
LS
D000818:Animals; D001402:B-Lymphocytes / Q000378:metabolism* / Q000473:pathology / Q000821:virology; D001853:Bone Marrow / Q000378:metabolism / Q000473:pathology / Q000821:virology; D002415:Cats; D002454:Cell Differentiation; D006411:Hematopoiesis, Extramedullary; D005256:Leukemia Virus, Feline / Q000378:metabolism*; D051379:Mice; D008979:Moloney murine leukemia virus / Q000378:metabolism*; D023461:Myeloid Progenitor Cells / Q000378:metabolism* / Q000473:pathology / Q000821:virology; D012192:Retroviridae Infections / Q000378:metabolism* / Q000473:pathology; D014412:Tumor Virus Infections / Q000401:mortality* / Q000473:pathology