title: Povidone iodine-induced overt hypothyroidism in a patient with prolonged habitual gargling: urinary excretion of iodine after gargling in normal subjects.
abstract: Iodine-induced hypothyroidism that develops in patients who gargle routinely with povidone iodine is well known. Usually the hypothyroidism is mild and resolves spontaneously upon cessation of gargling. Here, we report a 63-year-old patient with overt hypothyroidism that developed due to habitual gargling with povidone iodine for more than 10 years. The urinary excretion of iodine was estimated to be greater than 5 mg/day, based on values obtained from 18 normal subjects who gargled three times a day (4.6+/-2.1 mg, mean+/-SD). After discontinuation of the gargling, the patient has been euthyroid for more than 10 months.
authors.affiliation: Institute of Clinical Endocrinology, Tokyo Women's Medical University, Tokyo, Japan. satokan@attglobal.net <satokan@attglobal.net>
authors.forename: Kanji
authors.initials: K
authors.lastname: Sato
authors.forename: Teppei
authors.initials: T
authors.lastname: Ohmori
authors.forename: Keiko
authors.initials: K
authors.lastname: Shiratori
authors.forename: Kazuko
authors.initials: K
authors.lastname: Yamazaki
authors.forename: Emiko
authors.initials: E
authors.lastname: Yamada
authors.forename: Hironari
authors.initials: H
authors.lastname: Kimura
authors.forename: Kazue
authors.initials: K
authors.lastname: Takano
mesh_terms: D000368:Aged; D005500:Follow-Up Studies; D006801:Humans; D007037:Hypothyroidism / Q000139:chemically induced* / Q000175:diagnosis; D007455:Iodine / Q000378:metabolism / Q000652:urine; D008297:Male; D008875:Middle Aged; D009067:Mouthwashes / Q000009:adverse effects* / Q000737:chemistry; D011206:Povidone-Iodine / Q000009:adverse effects*; D018570:Risk Assessment; D012720:Severity of Illness Index; D013960:Thyroid Function Tests
chemical_list: D009067:Mouthwashes; D011206:Povidone-Iodine; D007455:Iodine