title: Luminescence of a Pt(II) complex in the presence of DNA. Dependence of luminescence changes on the interaction binding mode.
abstract: Luminescence intensity changes of a Pt(II) complex which is known to bind externally to DNA at low [DNA]/[complex] ratio and to intercalate at high [DNA]/[complex] ratio are studied in the presence of calf thymus DNA. External binding is demonstrated to induce luminescence enhancement whereas intercalation leads to luminescence quenching. The reasons for this behaviour are discussed.
authors.affiliation: Dipartimento di Chimica Inorganica, Chimica Analitica e Chimica Fisica, Università di Messina, Salita Sperone 31, 98166, Vill. S. Agata, Messina.
authors.forename: Fausto
authors.initials: F
authors.lastname: Puntoriero
authors.forename: Sebastiano
authors.initials: S
authors.lastname: Campagna
authors.forename: Maria Letizia
authors.initials: ML
authors.lastname: Di Pietro
authors.forename: Antonino
authors.initials: A
authors.lastname: Giannetto
authors.forename: Matteo
authors.initials: M
authors.lastname: Cusumano
mesh_terms: D000818:Animals; D001665:Binding Sites; D001667:Binding, Competitive; D002417:Cattle; D004247:DNA / Q000737:chemistry*; D007364:Intercalating Agents / Q000138:chemical synthesis / Q000737:chemistry*; D049449:Luminescence; D049408:Luminescent Agents / Q000138:chemical synthesis / Q000737:chemistry*; D015394:Molecular Structure; D009944:Organoplatinum Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D011119:Polynucleotides / Q000737:chemistry; D012680:Sensitivity and Specificity; D013056:Spectrophotometry, Ultraviolet / Q000379:methods
chemical_list: D007364:Intercalating Agents; D049408:Luminescent Agents; D009944:Organoplatinum Compounds; D011119:Polynucleotides; D004247:DNA; C427203:calf thymus DNA