title: Ambulatory blood pressure monitoring in hypertensive patients with high cardiovascular risk: a cross-sectional analysis of a 20,000-patient database in Spain.
abstract: OBJECTIVE
  To evaluate ambulatory blood pressure monitoring (ABPM) parameters in a broad sample of high-risk hypertensive patients.
  
  
  METHODS
  The Spanish Society of Hypertension is developing a nationwide project in which more than 900 physicians send ABPM registries and corresponding clinical records to a central database via www.cardiorisc.com. Between June 2004 and July 2005 a 20 000-patient database was obtained; 17 219 were valid for analysis.
  
  
  RESULTS
  We identified 6534 patients with high cardiovascular risk according to the 2003 European Society of Hypertension/European Society of Cardiology guidelines stratification score. Office blood pressure (BP) was 158.8/89.9 mmHg and 24-h BP was 135.8/77.0 mmHg. Patients with grade 3 BP in the office showed ambulatory systolic BP values less than 160 mmHg in more than 80%. A non-dipping pattern was observed in 3836 cases (58.7%), whereas this abnormality was present in 47.9% of patients with low-to-moderate risk [odds ratio (OR) 1.54; 95% confidence interval (CI) 1.45-1.64]. The prevalence of non-dippers was higher as ambulatory BP increased ( approximately 70% when 24-h systolic BP > 155 mmHg) and was similar in both groups. At the lowest levels of BP (24-h systolic BP < 135 mmHg) a non-dipping pattern was more prevalent in high-risk cases (56.6 versus 45.7%; OR 1.51; 95% CI 1.40-1.64).
  
  
  CONCLUSIONS
  There was a remarkable discrepancy between office and ambulatory BP in high-risk hypertensive patients. The prevalence of a non-dipper BP pattern was almost 60%. In the lowest levels of ambulatory BP, high-risk patients showed a higher prevalence of non-dipping BP than lower-risk cases. These observations support the recommendation of a wider use of ABPM in high-risk hypertensive patients.
authors.affiliation: Hospital San Agustín, Avilés, Asturias, Spain. manuel.gorostidi@sespa.princast.es
authors.forename: Manuel
authors.initials: M
authors.lastname: Gorostidi
authors.forename: Javier
authors.initials: J
authors.lastname: Sobrino
authors.forename: Julián
authors.initials: J
authors.lastname: Segura
authors.forename: Cristina
authors.initials: C
authors.lastname: Sierra
authors.forename: Alex
authors.initials: A
authors.lastname: de la Sierra
authors.forename: Raquel
authors.initials: R
authors.lastname: Hernández del Rey
authors.forename: Ernest
authors.initials: E
authors.lastname: Vinyoles
authors.forename: Josep M
authors.initials: JM
authors.lastname: Galcerán
authors.forename: María D
authors.initials: MD
authors.lastname: López-Eady
authors.forename: Rafael
authors.initials: R
authors.lastname: Marín
authors.forename: José R
authors.initials: JR
authors.lastname: Banegas
authors.forename: Antonio
authors.initials: A
authors.lastname: Sarría
authors.forename: Antonio
authors.initials: A
authors.lastname: Coca
authors.forename: Luis M
authors.initials: LM
authors.lastname: Ruilope
mesh_terms: D000368:Aged; D001794:Blood Pressure / Q000502:physiology*; D018660:Blood Pressure Monitoring, Ambulatory; D002318:Cardiovascular Diseases / Q000175:diagnosis; D002940:Circadian Rhythm / Q000502:physiology*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012307:Risk Factors