Hedgehog signaling pathway and lung cancer.
Signaling pathways responsible for embryogenesis play a critical role in the maintenance of stem cells in adult life and cellular responses to injury. Dysfunction of the developmental signaling pathways during adult homeostasis leads to various events resulting in the development of neoplasia. We review the biology of the hedgehog signaling pathway and its potential role in the development of lung cancer.
Velcheti
Vamsidhar
V
Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Govindan
Ramaswamy
R
D000818:Animals; D053823:Hedgehog Proteins / Q000037:antagonists & inhibitors / Q000502:physiology*; D006801:Humans; D008168:Lung / Q000196:embryology / Q000378:metabolism; D008175:Lung Neoplasms / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology*; D015398:Signal Transduction
D053823:Hedgehog Proteins