Cerebral activation in patients with somatoform pain disorder exposed to pain and stress: an fMRI study.
Patients with somatoform pain disorders are supposed to suffer from an early acquired defect in stress regulation. In order to look for common alterations of the pain- and stress-responsive cortical areas, we prospectively recorded cerebral activations induced by pin-prick pain, by cognitive stress and emotional stress using functional magnetic resonance imaging (fMRI) in a group of 17 patients and an age-matched control group. In addition, the hippocampal volumes of both groups were measured. Patients showed increased activations of the known pain-processing areas (thalamus, basal ganglia, operculo-insular cortex), but also of some prefrontal, temporal and parietal regions during first pain exposure and of temporal and parietal areas during cognitive stress, but reduced activations during emotional stress. In contrast to these functional differences, hippocampal volume was not significantly reduced in patients. Although the superior temporal gyrus was the only common area of an "overactivation" in patients in the pain and stress condition, findings of our study support the current concept of mechanisms involved in somatoform pain disorders: central processing of pain and of cognitive stress is increased in patients possibly due to exaggerated memory and/or anticipation of pain exposure and to a disturbance of stress-regulating systems which has to be worked out on a cortical level in more detail. Our finding of a reduced responsiveness to emotional stress is surprising, but not contradictive to these results because some sort of neglect or coping mechanisms may have developed over time as a response to early adversities.
Stoeter
P
P
Institute of Neuroradiology, University Clinic Mainz, Langenbeckstr. 1, D-55101 Mainz, Germany. stoeter@neuroradio.klinik.uni-mainz.de
Bauermann
Th
T
Nickel
R
R
Corluka
L
L
Gawehn
J
J
Vucurevic
G
G
Vossel
G
G
Egle
U T
UT
D000200:Action Potentials; D000328:Adult; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping / Q000379:methods*; D005073:Evoked Potentials, Somatosensory; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000150:complications / Q000503:physiopathology*; D017288:Pain Threshold; D013001:Somatoform Disorders / Q000150:complications / Q000503:physiopathology*; D013312:Stress, Physiological / Q000150:complications / Q000503:physiopathology*