Corpus callosotomy for treatment of pediatric epilepsy in the modern era.
OBJECTIVE
The purpose of this study was to evaluate seizure outcome in children with intractable secondary generalized epilepsy without a resectable focus who underwent complete corpus callosotomy and compare these results to those of anterior two-third callosotomy.


METHODS
Data were obtained for all patients who underwent a corpus callosotomy from 2000 to 2005. The study involved 37 patients. Eleven patients had anterior two-third corpus callosotomy compared with 28 patients who underwent complete corpus callosotomy. Two of these patients had completion of their callosotomy following initial partial callosotomy. Seizure type, seizure frequency, and family satisfaction were evaluated for all patients pre- and postoperatively.


RESULTS
A reduction of >or=75% in seizures occurred in 75% of the total-callosotomy patients compared to 55% of the partial-callosotomy patients. Family satisfaction for complete and partial callosotomy was 89 and 73%, respectively. No prolonged neurologic deficits were observed in either group.


CONCLUSIONS
Complete corpus callosotomy is the most effective treatment for secondary generalized intractable seizures not amenable to focal resection in children.
Rahimi
Scott Y
SY
Department of Neurosurgery, Medical College of Georgia Children's Medical Center, Augusta, GA 30912-2900, USA.
Park
Yong D
YD
Witcher
Mark R
MR
Lee
Ki H
KH
Marrufo
Manuel
M
Lee
Mark R
MR
D002648:Child; D002675:Child, Preschool; D003337:Corpus Callosum / Q000601:surgery*; D003399:Craniotomy; D004831:Epilepsies, Myoclonic / Q000175:diagnosis / Q000601:surgery; D004832:Epilepsy, Absence / Q000175:diagnosis / Q000601:surgery; D017029:Epilepsy, Complex Partial / Q000175:diagnosis / Q000601:surgery; D004829:Epilepsy, Generalized / Q000175:diagnosis / Q000601:surgery*; D004830:Epilepsy, Tonic-Clonic / Q000175:diagnosis / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D008297:Male; D011183:Postoperative Complications / Q000209:etiology; D013525:Surgical Instruments