Non-redundant peptidomes from DAPs: towards "the vaccine"?
Experimental analyses and literature survey reveal low-redundancy to the host proteins as a common denominator of immunogenic sequences mapped along tumor-, autoimmune-, and infectious disease-associated-proteins. The hypothesis that immunogenicity of peptide sequences is linked to proteomic redundancy is discussed.
Kanduc
Darja
D
Department of Biochemistry and Molecular Biology, University of Bari, Italy. d.kanduc@biologia.uniba.it
Lucchese
Alberta
A
Mittelman
Abraham
A
D000595:Amino Acid Sequence; D000818:Animals; D000918:Antibody Specificity; D030541:Databases, Genetic; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D010455:Peptides / Q000235:genetics / Q000276:immunology*; D020543:Proteome / Q000235:genetics / Q000276:immunology*; D014612:Vaccines / Q000737:chemistry / Q000276:immunology*
D010455:Peptides; D020543:Proteome; D014612:Vaccines