title: Anaemia and abdominal pain due to occupational lead poisoning.
abstract: We describe a 47-year-old patient with chronic anaemia with basophilic stippling of erythrocytes, recurrent abdominal colics, discoloration of gums, sensitive polyneuropathy to the four limbs, hyperuricaemia, hepatosteatosis with raised transaminases, and a long ignored history of lead exposure in a battery recycling plant. The diagnosis of poisoning was confirmed by high lead levels in the blood and urine, decreased erythrocyte delta-aminolevulinic acid dehydratase (ALA-D), raised erythrocyte zinc protoporphyrin (ZP), and elevated urinary excretion of porphyrins. Chelation with EDTA resulted in increased urinary lead excretion, gradual improvement of the clinical picture, and progressive normalization of lead biomarkers. The case highlights the importance of occupational anamnesis for the diagnosis of lead poisoning, an uncommon condition which may mimic a variety of internal and surgical diseases. Since antiquity, lead has been extensively mined, produced, and utilized in a variety of industrial settings, such as metallurgy, construction, production of plastics, ceramics, paints and pigments. Lead and its compounds are systemic toxicants, and a wide range of adverse health effects (including haematological, gastrointestinal, neuropsychiatric, cardiovascular, renal, endocrine, and reproductive disorders) has been observed in exposed workers. The general population (particularly children) may also be exposed to toxic lead levels due to air, soil, food and water contamination. Thanks to the improvement of workplace hygienic conditions, the pathological picture of occupational lead poisoning (plumbism, saturnism) has gradually become less serious, at least in the most industrialized countries, and has progressively changed into aspecific, subclinical manifestations. We describe here an unusual case (nowadays) of anaemia and recurrent abdominal pain due to lead poisoning from battery recycling.
authors.affiliation: Internal Medicine and Endocrinology Unit, Salvatore Maugeri Foundation, Work and Rehabilitation, IRCCS, Scientific Institute of Pavia, Italy.
authors.forename: Rodolfo
authors.initials: R
authors.lastname: Fonte
authors.forename: Antonio
authors.initials: A
authors.lastname: Agosti
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Scafa
authors.forename: Stefano M
authors.initials: SM
authors.lastname: Candura
mesh_terms: D015746:Abdominal Pain / Q000139:chemically induced*; D000740:Anemia / Q000139:chemically induced*; D003247:Conservation of Natural Resources; D006801:Humans; D007854:Lead / Q000097:blood / Q000652:urine; D007855:Lead Poisoning / Q000097:blood / Q000150:complications* / Q000175:diagnosis / Q000652:urine; D008297:Male; D008487:Medical History Taking; D008669:Metallurgy; D008875:Middle Aged; D009784:Occupational Diseases / Q000097:blood / Q000150:complications* / Q000175:diagnosis / Q000652:urine; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced; D000623:Porphobilinogen Synthase / Q000097:blood; D011166:Porphyrins / Q000652:urine; D011524:Protoporphyrins / Q000097:blood
chemical_list: D011166:Porphyrins; D011524:Protoporphyrins; C017803:zinc protoporphyrin; D007854:Lead; D000623:Porphobilinogen Synthase