title: Relationship between cytokine response and temporary ventilation during one-lung ventilation in esophagectomy.
abstract: OBJECTIVE
  Postoperative pulmonary complications are often fatal in patients with esophageal cancer. The aim of this study was to clarify the association between cytokines and temporary ventilation during one-lung ventilation.
  
  
  METHODS
  Serum and BALF IL-6, 8 were measured in 39 patients with esophageal cancer, and the relationship between cytokine response and temporary ventilation during one-lung ventilation in esophagectomy was examined.
  
  
  RESULTS
  Pulmonary complications did not occur in our patients. Serum IL-6 levels were significantly increased in the high one-lung ventilation ratio and long-term one-lung ventilation groups. Serum IL-6 levels in the one or more times ventilation group during one-lung ventilation were significantly low compared to the no-ventilation group. There were no significant differences in serum IL-8 and BALF IL-6, 8 levels.
  
  
  CONCLUSIONS
  Our results indicate that it is important to ventilate one or more times during one-lung ventilation in order to reduce postoperative pulmonary complications.
authors.affiliation: Department of General Surgical Science, Gunma University Faculty of Medicine, Maebashi, Japan. hojima@showa.gunma-u.ac.jp
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Ojima
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kuwano
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kato
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Miyazaki
authors.forename: Masanobu
authors.initials: M
authors.lastname: Nakajima
authors.forename: Makoto
authors.initials: M
authors.lastname: Sohda
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Tsukada
mesh_terms: D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry; D004938:Esophageal Neoplasms / Q000601:surgery*; D016629:Esophagectomy; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000032:analysis / Q000097:blood; D016209:Interleukin-8 / Q000032:analysis / Q000097:blood; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000517:prevention & control; D012121:Respiration, Artificial / Q000379:methods
chemical_list: D015850:Interleukin-6; D016209:Interleukin-8