Adiponectin level and left ventricular hypertrophy in Japanese men.
A recent study has demonstrated that adiponectin inhibited hypertrophic signaling in the myocardium of mice, implying that a decrease in the blood adiponectin level could cause cardiac muscle hypertrophy. We hypothesized that a relationship might exist between the serum adiponectin level and electrocardiographically diagnosed left ventricular hypertrophy (ECG-LVH), and we examined this hypothesis by epidemiological study of 2839 Japanese male workers who were not taking medications for hypertension. ECG-LVH was defined as meeting Sokolow-Lyon voltage criteria and/or Cornell voltage-duration product. The subjects were categorized by tertiles of serum adiponectin level, and a multivariate logistic regression analysis was conducted relating left ventricular hypertrophy to adiponectin tertiles adjusting for potential confounding factors. Prevalence of ECG-LVH in the studied sample was 16.7%. Adiponectin ranged from 1.0 to 5.0 microg/mL in the lowest category and from 7.4 to 30.6 microg/mL in the highest. Compared with subjects in the highest adiponectin category, those in the lowest one had a significantly higher prevalence of ECG-LVH independent of age, body mass index, and systolic blood pressure with an odds ratio of 1.50 and a 95% CI of 1.16 to 1.94. Further adjustment for high-density lipoprotein cholesterol, triglyceride, and insulin resistance did not change the association (odds ratio: 1.68; 95% CI: 1.28 to 2.21; P<0.001). Similar results were obtained when different criteria for ECG-LVH were used or when subjects were stratified by blood pressure or body mass index. Adiponectin concentration was inversely and independently associated with ECG-LVH in Japanese men.
Mitsuhashi
Hirotsugu
H
Department of Public Health/Health Information Dynamics, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan.
Yatsuya
Hiroshi
H
Tamakoshi
Koji
K
Matsushita
Kunihiro
K
Otsuka
Rei
R
Wada
Keiko
K
Sugiura
Kaichiro
K
Takefuji
Seiko
S
Hotta
Yo
Y
Kondo
Takahisa
T
Murohara
Toyoaki
T
Toyoshima
Hideaki
H
D052242:Adiponectin / Q000097:blood* / Q000502:physiology; D000328:Adult; D000368:Aged; D015992:Body Mass Index; D004562:Electrocardiography; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000097:blood* / Q000453:epidemiology* / Q000503:physiopathology; D007564:Japan / Q000453:epidemiology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D015995:Prevalence
D052242:Adiponectin