Syntheses and anti-HIV activities of (+/-)-norcarbovir and (+/-)-norabacavir.
Norcarbovir (1) and norabacavir (2), the desmethylene derivatives of anti-HIV agents carbovir and abacavir, were efficiently synthesized from a common intermediate . Their antitumor and antiviral activities were evaluated and the results indicate norabacavir showed comparable anti-HIV activity to that of abacavir.
Huang
Weiqiang
W
Department of Chemistry & Biochemistry, University of Notre Dame, 251 Nieuwland Science Hall, Notre Dame, Indiana 46556, USA.
Miller
Marvin J
MJ
De Clercq
Erik
E
Balzarini
Jan
J
D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D015224:Dideoxynucleosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015497:HIV-1 / Q000187:drug effects*; D015498:HIV-2 / Q000187:drug effects*; D006801:Humans; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D019380:Anti-HIV Agents; D015224:Dideoxynucleosides; C522560:norabacavir; C522559:norcarbovir