Cardiovascular risk factors are reduced with a low dose of acarbose in obese patients with polycystic ovary syndrome.
Polycystic ovary syndrome (PCOS) is defined by menstrual irregularity, hyperandrogenism, chronic anovulation, and enlarged ovaries with multiple follicles. Polycystic ovary syndrome is highly prevalent in women, affecting up to 10% of all women of reproductive age and reducing the possibility of spontaneous conception. In addition to altering reproductive function, PCOS has systemic implications, especially in the cardiovascular system. Cardiovascular risk (CVR) in PCOS patient increases because of insulin resistance, elevated androgen levels, and association with obesity. Those alterations promote cardiovascular risk factors, such as endothelial dysfunction, elevated homocysteine levels, left ventricular hypertrophy, and reduced high-density lipoprotein (HDL) cholesterol (1).
Araujo Penna
Ivan
I
Department of Obstetrics and Gynecology, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil; Gynecology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Canella
Paulo Roberto Bastos
PR
Vieira
Carolina Sales
CS
Silva de Sá
Marcos Felipe
MF
dos Reis
Rosana Maria
RM
Ferriani
Rui Alberto
RA
D020909:Acarbose / Q000008:administration & dosage*; D000328:Adult; D002318:Cardiovascular Diseases / Q000209:etiology / Q000517:prevention & control*; D015243:Cholesterol, VLDL / Q000097:blood; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D017588:Hyperandrogenism / Q000188:drug therapy; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D009765:Obesity / Q000097:blood / Q000150:complications* / Q000188:drug therapy*; D019007:P-Selectin / Q000097:blood; D010919:Placebos; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000150:complications* / Q000188:drug therapy*; D012307:Risk Factors
D015243:Cholesterol, VLDL; D007004:Hypoglycemic Agents; D019007:P-Selectin; D010919:Placebos; D020909:Acarbose