title: First example of direct RuO4-catalyzed oxidation of isoxazolidines to 3-isoxazolidones.
abstract: RuO2/NaIO4 oxidation of 3-unsubstituted isoxazolidines, under ethyl acetate/water biphasic conditions, affords 3-isoxazolidones in good yields. The methodology can be used on both racemic and optically active isoxazolidines.
authors.affiliation: Dipartimento Farmaco-Chimico, Università di Messina, Via SS. Annunziata, Messina 98168, Italy. apiperno@pharma.unime.it
authors.forename: Anna
authors.initials: A
authors.lastname: Piperno
authors.forename: Ugo
authors.initials: U
authors.lastname: Chiacchio
authors.forename: Daniela
authors.initials: D
authors.lastname: Iannazzo
authors.forename: Salvatore V
authors.initials: SV
authors.lastname: Giofrè
authors.forename: Giovanni
authors.initials: G
authors.lastname: Romeo
authors.forename: Roberto
authors.initials: R
authors.lastname: Romeo
mesh_terms: D000475:Alkenes / Q000737:chemistry; D002384:Catalysis; D007555:Isoxazoles / Q000138:chemical synthesis / Q000737:chemistry*; D015394:Molecular Structure; D010084:Oxidation-Reduction; D017975:Ruthenium Compounds / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000475:Alkenes; D007555:Isoxazoles; D017975:Ruthenium Compounds; C027646:ruthenium tetraoxide