Elevated plasma levels of high mobility group box protein 1 in patients with HIV-1 infection.
High mobility group box protein 1 (HMGB1) is a potent proinflammatory mediator. It has a dichotomic effect on HIV-1 replication in vitro but its role in vivo is unknown. Here we report the novel finding that plasma HMGB1 levels are elevated in HIV-1-infected patients, with the highest concentrations in patients with clinical complications. HMGB1 is likely to contribute to immunoactivation in HIV-1 infection in vivo.
Nowak
Piotr
P
Divisions of Clinical Virology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Barqasho
Babilonia
B
Sönnerborg
Anders
A
D017088:AIDS-Related Opportunistic Infections / Q000097:blood; D018791:CD4 Lymphocyte Count; D005260:Female; D015658:HIV Infections / Q000097:blood* / Q000276:immunology / Q000821:virology; D015497:HIV-1; D024243:HMGB1 Protein / Q000097:blood*; D006801:Humans; D008297:Male; D019562:Viral Load
D024243:HMGB1 Protein