title: Normalization of dye bias in microarray data using the mixture of splines model.
abstract: This paper discusses characteristics of dye biases in microarray data that the conventional normalization methods do not handle, and proposes a new normalization method involving a mixture of splines model. We also develop a test for between-group comparisons of each gene that is designed to be used with our proposed method.
authors.affiliation: University of Florida, USA. yjoo@phhp.ufl.edu
authors.forename: Yongsung
authors.initials: Y
authors.lastname: Joo
authors.forename: George
authors.initials: G
authors.lastname: Casella
authors.forename: James
authors.initials: J
authors.lastname: Booth
authors.forename: Keunbaik
authors.initials: K
authors.lastname: Lee
authors.forename: Steven
authors.initials: S
authors.lastname: Enkemann
mesh_terms: D018076:DNA, Complementary; D005456:Fluorescent Dyes; D008962:Models, Theoretical; D020411:Oligonucleotide Array Sequence Analysis; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D018076:DNA, Complementary; D005456:Fluorescent Dyes