Protective effects of lamotrigine, aripiprazole and escitalopram on depression-induced oxidative stress in rat brain.
We investigated the effects of lamotrigine, aripiprazole and escitalopram administration and experimental depression on lipid peroxidation (LP) and antioxidant levels in cortex of the brain in rats. Forty male wistar rats were randomly divided into five groups. First group was used as control although second group was depression-induced group. Aripiprazole, lamotrigine and escitalopram per day were orally supplemented to chronic mild stress (CMS) depression-induced rats constituting the third, fourth and fifth groups for 28 days, respectively. Depression resulted in significant decrease in the glutathione peroxidase (GSH-Px) activity, reduced glutathione and vitamin C of cortex of the brain although their levels and beta-carotene concentrations were increased by the three drugs administrations to the animals of CMS induced depression group. The LP levels in the cortex of the brain and plasma of depression group were elevated although their levels were decreased by the administrations. The increases of antioxidant values in lamotrigine group were higher according to aripiprazole and escitalopram supplemented groups. Vitamin A level did not change in the five groups. In conclusion, the experimental depression is associated with elevated oxidative stress although treatment with lamotrigine has most protective effects on the oxidative stress within three medicines.
Eren
Ibrahim
I
Department of Psychiatry, Medical Faculty, Suleyman Demirel University, Isparta, Turkey.
Naziroğlu
Mustafa
M
Demirdaş
Arif
A
D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D000068180:Aripiprazole; D001205:Ascorbic Acid / Q000378:metabolism; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002121:Calcium Channel Blockers / Q000494:pharmacology; D015283:Citalopram / Q000494:pharmacology*; D005978:Glutathione / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D000077213:Lamotrigine; D015227:Lipid Peroxidation; D008297:Male; D018696:Neuroprotective Agents / Q000494:pharmacology*; D018384:Oxidative Stress; D010879:Piperazines / Q000494:pharmacology*; D015363:Quinolones / Q000494:pharmacology*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology*; D014227:Triazines / Q000494:pharmacology*; D014801:Vitamin A / Q000378:metabolism; D019207:beta Carotene / Q000378:metabolism
D014150:Antipsychotic Agents; D000068180:Aripiprazole; D001205:Ascorbic Acid; D002121:Calcium Channel Blockers; D015283:Citalopram; D005978:Glutathione; D005979:Glutathione Peroxidase; D000077213:Lamotrigine; D018696:Neuroprotective Agents; D010879:Piperazines; D015363:Quinolones; D017367:Selective Serotonin Reuptake Inhibitors; D014227:Triazines; D014801:Vitamin A; D019207:beta Carotene