title: [Association of L-selectin gene polymorphism with susceptibility to coronary heart disease].
abstract: OBJECTIVE
  To investigate the possible association between L-selectin gene P213S polymorphism and coronary heart disease (CHD) in Chinese population.
  
  
  METHODS
  In total 212 CHD patients diagnosed by angiography and 230 healthy controls were studied. The genotype and allele frequencies of L-selectin gene polymorphism were assayed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).
  
  
  RESULTS
  The frequency of the L-selectin gene 213P allele in CHD patients was significantly higher than that in the control group (77.59% vs 69.35%, P=0.006). Compared with the SS genotype, PP homozygote had a significantly increased CHD risk (OR=2.70 and OR=2.15 using unadjusted and adjusted Logistic regression models, respectively). No association was found between the severity of CHD and the Lselectin gene P213S polymorphism
  
  
  CONCLUSIONS
  Our findings suggest that L-selectin gene 213P mutant allele might contribute to susceptibility of Chinese individuals to contract CHD.
authors.affiliation: Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan, Hubei, 430060 PR China.
authors.forename: Zun-en
authors.initials: ZE
authors.lastname: Xia
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Kai-hua
authors.initials: KH
authors.lastname: Ming
authors.forename: Xiao-quan
authors.initials: XQ
authors.lastname: Xiong
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003327:Coronary Disease / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D019041:L-Selectin / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*
chemical_list: D019041:L-Selectin