title: Age and indication for referral to capsule endoscopy significantly affect small bowel transit times: the given database.
abstract: The purpose of this study was to examine the effect of age and selected indications for capsule endoscopy on small bowel transit times. Data on 67 clinical studies (790 subjects with different gastrointestinal pathologies [49.5% males; mean age, 51.9 +/- 18.33 years; range, 18-91 years] and 87 healthy volunteers) were retrieved from the company (Given Imaging, Ltd.)-sponsored database. All subjects swallowed the PillCam SB Capsule after a 12-hr fast. The capsule reached the cecum in all 877 participants. Indications for referral for capsule endoscopy were as follows: 372 obscure gastrointestinal bleeding, 96 suspected Crohn's disease, 65 celiac disease, 54 irritable bowel syndrome, and 116 familial adenomatous polyposis, intestinal lymphoma, or ulcerative colitis. One group consisted of patients <40 years old (n = 235), and the other patients 40 years old (n = 555). The younger group, volunteers, and Crohn's disease patients had significantly shorter small bowel transit times than the others (P < 0.001). Gastric emptying indirectly influenced capsule transit time.
authors.affiliation: Department of Gastroenterology, Hillel Yaffe Medical Center, P.O. Box 169, Hadera, 38100, Israel. fireman@hy.health.gov.il
authors.forename: Zvi
authors.initials: Z
authors.lastname: Fireman
authors.forename: Yael
authors.initials: Y
authors.lastname: Kopelman
authors.forename: Shosh
authors.initials: S
authors.lastname: Friedman
authors.forename: Hagit
authors.initials: H
authors.lastname: Ephrath
authors.forename: Eran
authors.initials: E
authors.lastname: Choman
authors.forename: Hila
authors.initials: H
authors.lastname: Debby
authors.forename: Rami
authors.initials: R
authors.lastname: Eliakim
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D053704:Capsule Endoscopy; D019992:Databases as Topic; D005260:Female; D005772:Gastrointestinal Transit / Q000502:physiology*; D006801:Humans; D007410:Intestinal Diseases / Q000175:diagnosis* / Q000503:physiopathology; D007421:Intestine, Small / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D018579:Patient Selection; D012017:Referral and Consultation / Q000458:organization & administration*; D015203:Reproducibility of Results; D012189:Retrospective Studies