Gap junction coding genes and schizophrenia: a genetic association study.
The aim of this study was to evaluate the association of genes that encode gap junction forming proteins and schizophrenia. Representative genetic candidates (Panx2 and Cx36) from two families of gap junction genes were selected for analysis. According to the present findings these genes represent both functional and positional candidates for schizophrenia. The sample was comprised of 381 schizophrenic patients, and the same number of matched controls was tested in this study in order to evaluate the possible influence of the aforementioned genes on the pathogenesis of schizophrenia. Four SNPs in the case of Panx2 and two SNPs in the case of Cx36 were selected for analysis. Allele-, genotype- and haplotype-wise association did not yield statistically significant results. These data do not suggest that Panx2 or Cx36 could increase the risk of schizophrenia in the Japanese population.
Aleksic
Branko
B
Department of Psychiatry, Nagoya University Graduate School of Medicine, Showa-ku, Tsurumai-Cho, 65, 466-8550, Nagoya, Aichi, Japan. branko@med.nagoya-u.ac.jp.
Ishihara
Ryoko
R
Department of Psychiatry, Nagoya University Graduate School of Medicine, Showa-ku, Tsurumai-Cho, 65, 466-8550, Nagoya, Aichi, Japan.
Takahashi
Nagahide
N
Department of Psychiatry, Nagoya University Graduate School of Medicine, Showa-ku, Tsurumai-Cho, 65, 466-8550, Nagoya, Aichi, Japan.
Maeno
Nobuhisa
N
Department of Psychiatry, Nagoya University Graduate School of Medicine, Showa-ku, Tsurumai-Cho, 65, 466-8550, Nagoya, Aichi, Japan.
Ji
Xiaofei
X
Department of Psychiatry, Nagoya University Graduate School of Medicine, Showa-ku, Tsurumai-Cho, 65, 466-8550, Nagoya, Aichi, Japan.
Saito
Shinichi
S
Department of Psychiatry, Nagoya University Graduate School of Medicine, Showa-ku, Tsurumai-Cho, 65, 466-8550, Nagoya, Aichi, Japan.
Inada
Toshiya
T
Department of Psychiatry, Teikyo University School of Medicine Chiba Medical Center, Chiba, 299-0111, Japan.
Ozaki
Norio
N
Department of Psychiatry, Nagoya University Graduate School of Medicine, Showa-ku, Tsurumai-Cho, 65, 466-8550, Nagoya, Aichi, Japan.
D000328:Adult; D000368:Aged; D000483:Alleles; D016022:Case-Control Studies; D017630:Connexins / Q000235:genetics*; D005260:Female; D017629:Gap Junctions / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012559:Schizophrenia / Q000209:etiology / Q000235:genetics*; D000097004:Gap Junction delta-2 Protein
D017630:Connexins; D000097004:Gap Junction delta-2 Protein; C492765:PANX2 protein, human