title: Synthesis of lipid derivatives of pyrrole polyamide and their biological activity.
abstract: Novel fatty acyl and phospholipid derivatives of pyrrole polyamide were synthesized. Their cytotoxicity against a cancer cell line of MT-4 cells and those infected by human immunodeficiency virus (HIV) was examined. Although no anti-HIV activity was found, their cytotoxicitty against the cancer cells was significantly enhanced by introducing a lipophilic group into the pyrrole polyamide.
authors.affiliation: Department of Biofunctional Chemistry, Graduate School of Natural Science and Technology, Okayama University, Okayama, Japan.
authors.forename: Masahiko
authors.initials: M
authors.lastname: Yamamoto
authors.forename: Changjin
authors.initials: C
authors.lastname: Zhu
authors.forename: Lui
authors.initials: L
authors.lastname: Yi
authors.forename: Zheng
authors.initials: Z
authors.lastname: Rong
authors.forename: Yoshie
authors.initials: Y
authors.lastname: Miura
authors.forename: Minoru
authors.initials: M
authors.lastname: Izumi
authors.forename: Shuhei
authors.initials: S
authors.lastname: Nakajima
authors.forename: Ken-Ichi
authors.initials: K
authors.lastname: Tanamoto
authors.forename: Sakayu
authors.initials: S
authors.lastname: Shimizu
authors.forename: Naomichi
authors.initials: N
authors.lastname: Baba
mesh_terms: D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D005227:Fatty Acids / Q000737:chemistry; D006801:Humans; D007202:Indicators and Reagents; D008055:Lipids / Q000138:chemical synthesis* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D009757:Nylons / Q000138:chemical synthesis* / Q000494:pharmacology*; D010743:Phospholipids / Q000737:chemistry; D011758:Pyrroles / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D019380:Anti-HIV Agents; D000970:Antineoplastic Agents; D005227:Fatty Acids; D007202:Indicators and Reagents; D008055:Lipids; D009757:Nylons; D010743:Phospholipids; D011758:Pyrroles