Plasma membrane Ca2+ ATPase 2 contributes to short-term synapse plasticity at the parallel fiber to Purkinje neuron synapse.
Plasma membrane Ca2+ ATPase 2 (PMCA2) is a fast, highly effective mechanism to control resting cytosolic Ca2+ and Ca2+ excursions in neurons and other excitable cells. The strong expression of PMCA2 in the cerebellum and the cerebellar behavioral deficits presented by PMCA2-/- knock-out mice all point to its importance for cerebellar circuit dynamics. Here, we provide direct functional evidence for the influence of presynaptic PMCA2-mediated Ca2+ extrusion for short-term plasticity at cerebellar parallel fiber to Purkinje neuron synapses. Dramatic structural alterations to the Purkinje neurons in the absence of PMCA2 also suggest a strong influence of this fast PMCA2 isoform for development and maintenance of cerebellar function.
Empson
Ruth M
RM
School of Biological Sciences, Royal Holloway University of London, Egham, Surrey TW20 0EX, United Kingdom. ruth.empson@stonebow.otago.ac.nz
Garside
Molly L
ML
Knöpfel
Thomas
T
D000818:Animals; D002531:Cerebellum / Q000201:enzymology; D005260:Female; D007527:Isoenzymes / Q000172:deficiency / Q000235:genetics / Q000502:physiology; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D018656:Muscle Fibers, Fast-Twitch / Q000201:enzymology; D009473:Neuronal Plasticity / Q000502:physiology*; D053499:Plasma Membrane Calcium-Transporting ATPases / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D011689:Purkinje Cells / Q000201:enzymology*; D011930:Reaction Time; D013569:Synapses / Q000201:enzymology* / Q000235:genetics
D007527:Isoenzymes; D053499:Plasma Membrane Calcium-Transporting ATPases; C506959:Atp2b2 protein, mouse