Influence of bromazepam on cortical interhemispheric coherence.
Benzodiazepines are among the most commonly prescribed medications due to their therapeutic efficacy in reducing anxiety and inducing sleep. Consequently, they have been widely employed in the pharmacological treatment of several disorders. Nevertheless, few studies have analyzed the effects of bromazepam in electroencephalographic activity (EEG). The present study aimed at investigating the modulatory effects of this drug on brain dynamics. Specifically, the effects of bromazepam (3mg) on EEG coherence were tested in a double-blind experiment. The sample, consisting of 10 healthy subjects (5 male and 5 female), was submitted to ten minutes of EEG recording. The electrophysiological measure (coherence) was analyzed across three experimental conditions: bromazepam, placebo 1, and placebo 2. Results indicate that bromazepam significantly increases cortical interhemispheric coherence.
Sampaio
Isabel
I
Laboratório de Mapeamento Cerebral e Integração Sensório-Motora, Instituto de Psiquiatria, Universidade Federal do Rio de Janeiro, Avenida Venceslau Brás 71/Fundos, 22290-140 Rio de Janeiro, RJ, Brazil. belsampaio@gmail.com
Puga
Fernanda
F
Veiga
Heloisa
H
Cagy
Maurício
M
Piedade
Roberto
R
Ribeiro
Pedro
P
D000328:Adult; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001960:Bromazepam / Q000494:pharmacology*; D004311:Double-Blind Method; D004569:Electroencephalography / Q000187:drug effects*; D005260:Female; D007839:Functional Laterality / Q000187:drug effects*; D006801:Humans; D008297:Male; D009044:Motor Cortex / Q000187:drug effects*
D014151:Anti-Anxiety Agents; D001960:Bromazepam