Anti-angiogenic activity of the methanol extract and its fractions of Ulmus davidiana var. japonica.
This study aimed to elucidate anti-angiogenic activity of Ulmus davidiana var. japonica that has been widely used in folk medicine. The methanol extract (UDE) of Ulmus davidiana var. japonica concentration-dependently displayed a strong inhibition in the chick chorioallantoic membrane (CAM) angiogenesis. The n-butanol fraction of UDE and subsequent 30% MeOH subfraction were identified to be most responsible for the anti-angiogenic activity.
Jung
Hyun-Joo
HJ
College of Pharmacy, Sookmyung Women's University, Seoul 140-742, Republic of Korea.
Jeon
Hye-Jin
HJ
Lim
Eun-Ju
EJ
Ahn
Eun-Kyoung
EK
Song
Yun Seon
YS
Lee
Sanghyun
S
Shin
Kuk Hyun
KH
Lim
Chang-Jin
CJ
Park
Eun-Hee
EH
D020533:Angiogenesis Inhibitors / Q000494:pharmacology*; D000818:Animals; D002642:Chick Embryo; D049033:Chorioallantoic Membrane / Q000098:blood supply / Q000187:drug effects; D000432:Methanol; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D012039:Regional Blood Flow / Q000187:drug effects; D012997:Solvents; D034403:Ulmus / Q000737:chemistry*
D020533:Angiogenesis Inhibitors; D010936:Plant Extracts; D012997:Solvents; D000432:Methanol