title: Synthesis of 4-O-glycosylated 1-deoxynojirimycin derivatives as disaccharide mimics-based inhibitors of human beta-glucocerebrosidase.
abstract: Examples of a new type of inhibitor of human beta-glucocerebrosidase based on imino-disaccharides as glycosylceramide mimetics have been synthesized by way of the glycosylation of 1-deoxynojirimycin derivatives with 2,3,4,6-tetra-O-acetyl-alpha-D-glucopyranosyl bromide.
authors.affiliation: Institut de Chimie Organique et Analytique, CNRS-Université d'Orléans, rue de Chartres, BP 6759, 45067 Orléans, France.
authors.forename: Charlotte
authors.initials: C
authors.lastname: Boucheron
authors.forename: Sylvestre
authors.initials: S
authors.lastname: Toumieux
authors.forename: Philippe
authors.initials: P
authors.lastname: Compain
authors.forename: Olivier R
authors.initials: OR
authors.lastname: Martin
authors.forename: Kyoko
authors.initials: K
authors.lastname: Ikeda
authors.forename: Naoki
authors.initials: N
authors.lastname: Asano
mesh_terms: D017485:1-Deoxynojirimycin / Q000737:chemistry* / Q000494:pharmacology; D002236:Carbohydrate Conformation; D004187:Disaccharides / Q000138:chemical synthesis* / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis*; D005962:Glucosylceramidase / Q000037:antagonists & inhibitors*; D006031:Glycosylation; D006801:Humans; D007202:Indicators and Reagents; D007700:Kinetics; D008958:Models, Molecular; D008968:Molecular Conformation
chemical_list: D004187:Disaccharides; D004791:Enzyme Inhibitors; D007202:Indicators and Reagents; D017485:1-Deoxynojirimycin; D005962:Glucosylceramidase