title: Anti-inflammatory and immunosuppressive compounds from Tripterygium wilfordii.
abstract: The extract of Tripterygium wilfordii Hook F. (TwHF), which showed anti-inflammatory and immunosuppressive activities in human clinical trials for rheumatoid arthritis, was subjected to the activity-guided fractionation and spectroscopic characterization of bioactives. A tetrahydrofuran lignan, tripterygiol (1), and eight known compounds, all capable of suppressing pro-inflammatory gene expression were identified. Most of the pharmacological activity of the extract can be attributed to triptolide, its most abundant and active component, with some contribution from tripdiolide.
authors.affiliation: Biotech Center, Cook College, Rutgers University, 59 Dudley Road, New Brunswick, NJ 08901, USA.
authors.forename: Jun
authors.initials: J
authors.lastname: Ma
authors.forename: Moul
authors.initials: M
authors.lastname: Dey
authors.forename: Hui
authors.initials: H
authors.lastname: Yang
authors.forename: Alexander
authors.initials: A
authors.lastname: Poulev
authors.forename: Reneta
authors.initials: R
authors.lastname: Pouleva
authors.forename: Ruth
authors.initials: R
authors.lastname: Dorn
authors.forename: Peter E
authors.initials: PE
authors.lastname: Lipsky
authors.forename: Edward J
authors.initials: EJ
authors.lastname: Kennelly
authors.forename: Ilya
authors.initials: I
authors.lastname: Raskin
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002460:Cell Line; D005591:Chemical Fractionation; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004852:Epoxy Compounds / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D007166:Immunosuppressive Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D051379:Mice; D019906:Nuclear Magnetic Resonance, Biomolecular; D010616:Phenanthrenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry; D029757:Tripterygium / Q000737:chemistry*
chemical_list: D000893:Anti-Inflammatory Agents; D004224:Diterpenes; D004852:Epoxy Compounds; D007166:Immunosuppressive Agents; D010616:Phenanthrenes; D010936:Plant Extracts; C001899:triptolide; C001898:tripdiolide