title: Chemistry, 13C-NMR Study and Pharmacology of Two Saponins from Colubrina asiatica.
abstract: From the leaves of COLUBRINA ASIATICA B RONGEN (Rhamnaceae) two saponins have been isolated and structurally elucidated, mainly by (13)C-NMR-spectroscopic methods, as jujubogenin-3-O-[2-O-acetyl-3-O-(3-O-beta-D-xylopyranosyl-4-O-acetyl-beta-D-glucopyranosyl)-alpha-L-arabinoside] (colubrinoside) and jujubogenin-3-O- [2-O-acetyl -3-O- (2-O- beta -D- xylopyranosyl-beta-D-glucopyranosyl)-alpha-L-arabinoside] (colubrin) respectively. Both saponins inhibit the spontaneous motility of mice, even at low doses (1 mg/ kg), they show an antagonistic effect on amphetamine and exert a synergistic activity on chlordiazepoxide.
authors.affiliation: Institut für Pharmazeutische Biologie der Universität München.
authors.forename: H
authors.initials: H
authors.lastname: Wagner
authors.forename: S
authors.initials: S
authors.lastname: Ott
authors.forename: K
authors.initials: K
authors.lastname: Jurcic
authors.forename: J
authors.initials: J
authors.lastname: Morton
authors.forename: A
authors.initials: A
authors.lastname: Neszmelyi