Microbial transformation of the steroidal alkaloid dictyophlebine by Rhizopus stolonifer.
The microbial transformation of a steroidal alkaloid, dictyophlebine (1) with Rhizopus stolonifer (ATCC 10404) afforded three oxidized metabolites 2-4. Compound 2 was found to be a new product. These metabolites were structurally characterized on the basis of modern spectroscopic techniques. Their inhibitory activity towards acetyl- and butyrylcholinesterase has been evaluated and the new product 2 has been found to be more potent than the parent compound and other metabolites.
Devkota
Krishna Prasad
KP
Institute of Forestry, Tribhuvan University, Kaski, Nepal. devkotakpd@yahoo.com
Choudhary
Muhammad Iqbal
MI
Nawaz
Sarfaraz Ahmed
SA
Lannang
Alain Meli
AM
Lenta
Bruno Ndjakou
BN
Fokou
Patrice Aime
PA
Sewald
Norbert
N
D001711:Biotransformation; D009682:Magnetic Resonance Spectroscopy; D012233:Rhizopus / Q000378:metabolism*; D021241:Spectrometry, Mass, Electrospray Ionization; D013056:Spectrophotometry, Ultraviolet; D013256:Steroids / Q000737:chemistry / Q000378:metabolism*
D013256:Steroids; C520060:dictyophlebine