title: Perchlorate mixed-ligand copper(II) complexes of beta-diketone and ethylene diamine derivatives: thermal, spectroscopic and biochemical studies.
abstract: The present work carried out a study on perchlorate mixed-ligand copper(II) complexes which have been synthesized from ethylenediamine derivatives (3a-c) and beta-diketones. These complexes, namely [Cu(DA-Cl)(acac)H(2)O]ClO(4)4, [Cu(DA-Cl)(bzac)H(2)O]H(2)O.ClO(4)5, [Cu(DA-OMe)(acac)H(2)O]ClO(4)6, [Cu(DA-OMe)(bzac)H(2)O]ClO(4)7, [Cu(DA-H)(acac)H(2)O]2H(2)O.ClO(4)8 and [Cu(DA-H)(bzac)H(2)O]ClO(4)9 (where acac, acetylacetonate and bzac, benzoylacetonate) were characterized by elemental analysis, spectral (IR and UV-vis) and magnetic moment measurements. Thermal properties and decomposition kinetics of all complexes are investigated. The interpretation, mathematical analysis and evaluation of kinetic parameters (E, A, DeltaH, DeltaS and DeltaG) of all thermal decomposition stages have been evaluated using Coats-Redfern equation. The biochemical studies showed that, the diamines 3a-c have powerful effects on degradation of DNA and protein. The antibacterial screening demonstrated that, the diamine (DA-Cl), 3b has the maximum and broad activities against Gram +ve and Gram -ve bacterial strains.
authors.affiliation: Department of Chemistry, Faculty of Science, Mansoura University, Mansoura, Egypt. uelayaan@kfu.edu.sa
authors.forename: Usama
authors.initials: U
authors.lastname: El-Ayaan
authors.forename: Nashwa M
authors.initials: NM
authors.lastname: El-Metwally
authors.forename: Magdy M
authors.initials: MM
authors.lastname: Youssef
authors.forename: Serry A A
authors.initials: SA
authors.lastname: El Bialy
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D002417:Cattle; D003300:Copper / Q000737:chemistry* / Q000494:pharmacology; D004269:DNA, Bacterial / Q000378:metabolism; D004055:Differential Thermal Analysis; D004583:Electrons; D005029:Ethylenediamines / Q000737:chemistry* / Q000494:pharmacology; D007659:Ketones / Q000737:chemistry* / Q000494:pharmacology; D007700:Kinetics; D008024:Ligands; D008280:Magnetics; D008826:Microbial Sensitivity Tests; D010472:Perchlorates / Q000737:chemistry* / Q000494:pharmacology; D012710:Serum Albumin, Bovine / Q000378:metabolism; D013055:Spectrophotometry, Infrared; D013481:Superoxides / Q000378:metabolism; D013696:Temperature; D013818:Thermogravimetry
chemical_list: D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial; D005029:Ethylenediamines; D007659:Ketones; D008024:Ligands; D010472:Perchlorates; D013481:Superoxides; D012710:Serum Albumin, Bovine; D003300:Copper; C494474:perchlorate