title: An elderly case of type 2 diabetes which developed in association with oral and esophageal candidiasis.
abstract: A 75-year-old woman who had been healthy except for mild glycemia and lipidemia discovered three and a half months before admission experienced severe dysphagia secondary to oral and esophageal candidiasis. She eventually developed diabetic hyperosmolar syndrome and ketoacidosis. Since anti-GAD antibody was negative and her diabetes was controlled with a moderate dose of insulin, we made a diagnosis of type 2 diabetes. Her only risk factors for candidiasis were hyperglycemia, age, and continuous denture use. The fact that her diabetes developed in association with oral candidiasis supports the hypothesis that there is a bidirectional interrelationship between diabetes and oral infection.
authors.affiliation: Department of Endocrinology and Metabolism, International Medical Center of Japan, Tokyo, Japan.
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Takasawa
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Takahashi
authors.forename: Makiko
authors.initials: M
authors.lastname: Abe
authors.forename: Keiichiro
authors.initials: K
authors.lastname: Osame
authors.forename: Shigeru
authors.initials: S
authors.lastname: Watanabe
authors.forename: Tomoko
authors.initials: T
authors.lastname: Hisatake
authors.forename: Kazuki
authors.initials: K
authors.lastname: Yasuda
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Kaburagi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kajio
authors.forename: Mitsuhiko
authors.initials: M
authors.lastname: Noda
mesh_terms: D000368:Aged; D000935:Antifungal Agents / Q000627:therapeutic use; D002180:Candidiasis, Oral / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D004935:Esophageal Diseases / Q000150:complications* / Q000188:drug therapy / Q000382:microbiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D018570:Risk Assessment; D012720:Severity of Illness Index
chemical_list: D000935:Antifungal Agents; D007004:Hypoglycemic Agents