Prevention and treatment of congenital toxoplasmosis.
Infection with Toxoplasma gondii is transmitted to man by infected meat or meat products and by contact with soil or surface water. In theory, prevention by hygienic measures is possible, but this has never been proved to work in practice. Therefore, pre- and postnatal screening has been implemented in several countries aiming at early diagnosis. However, data on the effect of treatment are limited and no randomized, controlled trials have been performed. The risk of T. gondii infection in Europe is declining and studies using historical controls from earlier decades cannot be used for decision making. The screening of pregnant women or neonates makes the assumption that any children diagnosed can be offered an effective treatment. There is an urgent need to test new drugs and demonstrate, using randomized, controlled trials, that the currently used drugs are effective.
Petersen
Eskild
E
Aarhus University Hospital, Department of Infectious Diseases, DK8000 Aarhus, Denmark. epf@sks.aaa.dk
D000818:Animals; D000981:Antiprotozoal Agents / Q000494:pharmacology / Q000627:therapeutic use; D053626:Atovaquone / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D005506:Food Contamination / Q000517:prevention & control; D006801:Humans; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy / Q000517:prevention & control; D014122:Toxoplasma / Q000187:drug effects; D014125:Toxoplasmosis, Congenital / Q000188:drug therapy* / Q000517:prevention & control* / Q000635:transmission
D000981:Antiprotozoal Agents; D053626:Atovaquone