A novel monolayer cell line derived from human umbilical cord blood cells shows high sensitivity to measles virus.
Measles virus (MeV) research is largely dependent on the B95a cell line, which is derived from marmoset B lymphocytes. As this cell line is persistently infected with Epstein-Barr virus (EBV), a novel cell line, COBL-a, was established from human umbilical cord blood. COBL-a cells have a significant advantage over B95a cells because they are of human origin, are free from EBV and have higher sensitivity to wild-type MeV. Thus, COBL-a cells should prove very valuable for both epidemiological and basic studies of MeV.
Kobune
Fumio
F
NPO-Biomedical Science Association, Tokyo 169-0075, Japan.|Laboratory Animal Research Center, Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan.
Ami
Yasushi
Y
National Institute of Infectious Diseases (NIID), Tokyo 190-0011, Japan.
Katayama
Miki
M
NPO-Biomedical Science Association, Tokyo 169-0075, Japan.
Takahashi
Motohide
M
National Institute of Infectious Diseases (NIID), Tokyo 190-0011, Japan.
Tuul
Renchin
R
National Center for Communicable Diseases, Ulaanbaatar 48, Mongolia.
Korukluoglu
Gulay
G
National Measles Laboratory, Virology Department, Refik Saydam National Hygiene Center, Ankara 18-06100, Turkey.
Kiyohara
Tomoko
T
National Institute of Infectious Diseases (NIID), Tokyo 190-0011, Japan.
Miura
Ryuichi
R
Laboratory Animal Research Center, Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan.
Sato
Hiroki
H
Laboratory Animal Research Center, Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan.
Yoneda
Misako
M
Laboratory Animal Research Center, Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan.
Kai
Chieko
C
Laboratory Animal Research Center, Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan.
D000818:Animals; D001402:B-Lymphocytes / Q000821:virology; D001773:Blood Cells / Q000821:virology*; D002144:Callithrix; D002460:Cell Line; D005312:Fetal Blood / Q000166:cytology*; D006801:Humans; D007231:Infant, Newborn; D008459:Measles virus / Q000302:isolation & purification / Q000472:pathogenicity / Q000502:physiology*