title: Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1.
abstract: A series of 4-hydroxy-4-phenylpiperidines have been synthesized and bind to the nociceptin receptor with high affinity. The synthesis and structure-activity relationships at the N-1 and C-4 are described.
authors.affiliation: Department of Chemical Research-CV & CNS, Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA. ginny.ho@spcorp.com
authors.forename: Ginny D
authors.initials: GD
authors.lastname: Ho
authors.forename: Ana
authors.initials: A
authors.lastname: Bercovici
authors.forename: Deen
authors.initials: D
authors.lastname: Tulshian
authors.forename: William J
authors.initials: WJ
authors.lastname: Greenlee
authors.forename: Ahmad
authors.initials: A
authors.lastname: Fawzi
authors.forename: April
authors.initials: A
authors.lastname: Smith Torhan
authors.forename: Hongtao
authors.initials: H
authors.lastname: Zhang
mesh_terms: D000818:Animals; D016466:CHO Cells; D006224:Cricetinae; D003412:Cricetulus; D006801:Humans; D008024:Ligands; D015394:Molecular Structure; D010880:Piperidines / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism*; D011957:Receptors, Opioid / Q000378:metabolism*; D013329:Structure-Activity Relationship; D000094942:Nociceptin Receptor
chemical_list: D008024:Ligands; D010880:Piperidines; D011957:Receptors, Opioid; D000094942:Nociceptin Receptor