title: Perturbation of erythrocyte antioxidant barrier, lipid peroxidation and protein carbonylation in non-diabetic first degree relatives of patients with type 2 diabetes.
abstract: OBJECTIVE
  Oxidative stress plays an important role in the pathogenesis of type 2 diabetes. But it is still discussed whether oxidative stress precedes or merely reflects diabetic complications. The present study was carried out to search for the possibility of oxidative stress among the first degree relatives of patients with type 2 diabetes, as they are more prone to develop type 2 diabetes.
  
  
  METHODS
  This study has been conducted on 30 first degree relatives of patients with type 2 diabetes and 34 healthy subjects without any known family history of diabetes. Whole blood glutathione, plasma malondialdehyde (MDA), protein carbonylation, fasting glucose levels and the activities of anti-oxidant enzymes glutathione peroxidase, catalase and glutathione S-transferase were measured.
  
  
  RESULTS
  The antioxidant enzyme glutathione peroxidase, plasma MDA and protein carbonyl levels were significantly elevated in the test group compared with controls. The glutathione levels were significantly decreased in the test group.
  
  
  CONCLUSIONS
  This study reveals alteration of antioxidant status and oxidative stress among the first degree relatives of patients with type 2 diabetes.
authors.affiliation: Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry 605006, India.
authors.forename: V
authors.initials: V
authors.lastname: Sathiyapriya
authors.forename: N
authors.initials: N
authors.lastname: Selvaraj
authors.forename: Zachariah
authors.initials: Z
authors.lastname: Bobby
authors.forename: Aparna
authors.initials: A
authors.lastname: Agrawal
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000032:analysis*; D001786:Blood Glucose / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics* / Q000378:metabolism*; D004912:Erythrocytes / Q000502:physiology*; D005192:Family Health; D005260:Female; D005978:Glutathione / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D015227:Lipid Peroxidation / Q000502:physiology*; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D009679:Nuclear Family; D018384:Oxidative Stress / Q000502:physiology*; D050050:Protein Carbonylation
chemical_list: D000975:Antioxidants; D001786:Blood Glucose; D008315:Malondialdehyde; D005979:Glutathione Peroxidase; D005978:Glutathione