title: Age-related structural and functional changes in the breast: multimodality correlation with digital mammography, computed tomography, magnetic resonance imaging, and positron emission tomography.
abstract: Preliminary results generated from digital mammography, computed tomography, magnetic resonance imaging, and (18)F-fluorodeoxyglucose positron emission tomography demonstrate concordant findings of decreasing glandular tissue and decreasing metabolic activity with increasing age. These results are presented in the context of a detailed literature review summarizing age-related changes in the breast, both from the histologic/physiologic and the imaging perspectives. We also discuss potential applications of this approach and emphasize the importance of new advanced imaging technologies to offer high levels of quantitative precision for tissue characterization for research and clinical purposes.
authors.affiliation: Department of Radiology, Division of Nuclear Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-4283, USA.
authors.forename: Richard G
authors.initials: RG
authors.lastname: Abramson
authors.forename: Ayse
authors.initials: A
authors.lastname: Mavi
authors.forename: Tevfik
authors.initials: T
authors.lastname: Cermik
authors.forename: Sandip
authors.initials: S
authors.lastname: Basu
authors.forename: Natasha E
authors.initials: NE
authors.lastname: Wehrli
authors.forename: Mohamed
authors.initials: M
authors.lastname: Houseni
authors.forename: Shipra
authors.initials: S
authors.lastname: Mishra
authors.forename: Jay
authors.initials: J
authors.lastname: Udupa
authors.forename: Paras
authors.initials: P
authors.lastname: Lakhani
authors.forename: Andrew D A
authors.initials: AD
authors.lastname: Maidment
authors.forename: Drew A
authors.initials: DA
authors.lastname: Torigian
authors.forename: Abass
authors.initials: A
authors.lastname: Alavi
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000473:pathology*; D001940:Breast / Q000473:pathology* / Q000503:physiopathology*; D001943:Breast Neoplasms / Q000473:pathology* / Q000503:physiopathology*; D003952:Diagnostic Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography / Q000379:methods; D011856:Radiographic Image Enhancement / Q000379:methods; D014057:Tomography, X-Ray Computed / Q000379:methods