title: Use of fine needle aspiration cytology in leprotic lesions: a report of 4 cases.
abstract: BACKGROUND
  Although a few studies have shown fine needle aspiration cytology (FNAC) to be a sensitive diagnostic tool in the detection of nerve involvement, its role as an initial diagnostic procedure in pure neuritic leprosy (PNL) and in the detection of skeletal lesions with unusual findings has not been documented before.
  
  
  METHODS
  Three patients who presented with thickened nerves and a fourth with biopsy-proven lepromatous leprosy with lesions in hand bones underwent FNAC. Of the 3 patients with nerve thickening, 2 had a clinical suspicion or diagnosis of neuritic leprosy, whereas in the third patient a clinical differential diagnosis of a soft tissue tumor or parasitic cyst was considered. FNAC in all 3 cases revealed epithelioid cell granulomas, Langhans giant cells and caseous necrosis. Fites and Ziehl-Neelsen stains were negative for acid-fast bacilli. Cytologic diagnosis of pure neuritic leprosy was made in all 3 cases and confirmed by histopathologic examination. FNAC of skeletal lesions from the fourth patient confirmed involvement of bone with unusual cytologic findings of epithelioid cell granulomas and giant cells along with a significant proportion of foamy macrophages and strong Fites stain positivity.
  
  
  CONCLUSIONS
  FNAC is a simple, useful, minimally traumatic and routinely applicable procedure in the diagnosis of pure neuritic leprosy and leprous osteitis.
authors.affiliation: Department of Pathology, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India. rajusiddaraju@yahoo.com
authors.forename: Neelaiah
authors.initials: N
authors.lastname: Siddaraju
authors.forename: Parasappa Joteppa
authors.initials: PJ
authors.lastname: Yaranal
mesh_terms: D000328:Adult; D044963:Biopsy, Fine-Needle; D003937:Diagnosis, Differential; D050278:Finger Phalanges / Q000000981:diagnostic imaging / Q000382:microbiology / Q000473:pathology*; D006646:Histiocytosis, Langerhans-Cell / Q000382:microbiology / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D007194:India; D015440:Leprosy, Lepromatous / Q000000981:diagnostic imaging / Q000473:pathology* / Q000503:physiopathology; D008297:Male; D009336:Necrosis / Q000382:microbiology / Q000473:pathology / Q000503:physiopathology; D010525:Peripheral Nerves / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology; D010523:Peripheral Nervous System Diseases / Q000382:microbiology / Q000473:pathology* / Q000503:physiopathology; D011237:Predictive Value of Tests; D011859:Radiography