The relationship of gamma-glutamyltransferase to C-reactive protein and arterial stiffness.
OBJECTIVE
The relationships between gamma-glutamyltransferase (GGT), C-reactive protein (CRP), and arterial stiffness have not been fully investigated. The aim of this study was to clarify whether serum GGT is related to CRP and arterial stiffness estimated using brachial-ankle pulse wave velocity (baPWV).


RESULTS
The subjects were 3412 males and 854 females. GGT, CRP, baPWV, and conventional risk factors were evaluated. On multiple regression analysis, after adjustment for the conventional risk factors, log GGT was significantly associated with log CRP in male and female subjects (male subjects: beta=0.168, p<0.0001; female subjects: beta=0.098, p<0.05). After adjustment for the conventional risk factors, log GGT was significantly associated with PWV in male subjects (beta=0.060, p<0.0001), but in female subjects, no significant relationships were found after adjustment (beta=0.007, p=0.82).


CONCLUSIONS
These results suggest that GGT is independently associated with an increased level of CRP in both males and females. In addition, in males, GGT is related to an increased level of arterial stiffness.
Saijo
Yasuaki
Y
Department of Health Science, Asahikwa Medical College, Midorigaoka, E2-1-1-1, Asahikawa, Hokkaido 078-8510, Japan. y-saijo@asahikawa-med.ac.jp
Utsugi
Megumi
M
Yoshioka
Eiji
E
Horikawa
Naoko
N
Sato
Tetsuro
T
Gong
Yingyan
Y
Kishi
Reiko
R
D000842:Ankle / Q000098:blood supply; D050197:Atherosclerosis; D015415:Biomarkers / Q000097:blood; D001783:Blood Flow Velocity; D001794:Blood Pressure / Q000502:physiology; D015992:Body Mass Index; D001916:Brachial Artery / Q000502:physiology*; D002097:C-Reactive Protein / Q000378:metabolism*; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D011795:Surveys and Questionnaires; D005723:gamma-Glutamyltransferase / Q000097:blood*
D015415:Biomarkers; D002097:C-Reactive Protein; D005723:gamma-Glutamyltransferase