MgtC: a key player in intramacrophage survival.
Several bacterial pathogens have evolved strategies to survive in macrophages and create a replicative niche within phagosomes. The bacterial factor MgtC is a key player in intramacrophage survival, being important for virulence in diverse intracellular pathogens. MgtC is also required for growth under magnesium limitation. Recent studies provide new clues on the role of MgtC in macrophages, which seems to be unlinked to adaptation to a low Mg(2+) microenvironment. In addition, we discuss the unexpected finding that MgtC modulates host P-type ATPase activity.
Alix
Eric
E
Inserm, Espri 26, Avenue J.F. Kennedy, 30908 Nîmes cedex 02, France.
Blanc-Potard
Anne-Béatrice
AB
D000818:Animals; D001419:Bacteria / Q000737:chemistry / Q000254:growth & development* / Q000472:pathogenicity; D001426:Bacterial Proteins / Q000502:physiology*; D027682:Cation Transport Proteins / Q000502:physiology; D002412:Cations; D003470:Culture Media; D008264:Macrophages / Q000737:chemistry / Q000201:enzymology / Q000382:microbiology*; D008274:Magnesium; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D014774:Virulence; D037521:Virulence Factors / Q000502:physiology*
D001426:Bacterial Proteins; D027682:Cation Transport Proteins; D002412:Cations; D003470:Culture Media; D037521:Virulence Factors; C093586:MgtC protein, Salmonella typhimurium; D000254:Sodium-Potassium-Exchanging ATPase; D008274:Magnesium