Type I diabetes mellitus in human and chimpanzee: a comparison of kyoto encyclopedia of genes and genomes pathway.
BACKGROUND
Diabetes is a worldwide medical problem and is a significant cause of morbidity and mortality. Type 1 diabetes results from the autoimmune destruction of insulin-producing beta cells in the pancreas. The identification of causative genes for the autoimmune disease type 1 diabetes in humans has made significant progress in recent years. Studies of pathways for type 1 diabetes in other living things can give useful information on the nature of type 1 diabetes.


METHODS
Here, the author used a new pathway technology to compare type 1 diabetes mellitus in the human and the chimpanzee.


RESULTS
According to the comparison, the mainframes of pathways are similar for both the human and the chimpanzee.


CONCLUSIONS
These results can imply a close relation between the human and the chimpanzee. They also confirm usage of the chimpanzee model for studies of type 1 diabetes pathophysiology.
Wiwanitkit
Viroj
V
Department of Laboratory Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. wviroj@pioneer.netserv.chula.ac.th
D000818:Animals; D018420:Ape Diseases / Q000235:genetics*; D001324:Autoantigens / Q000235:genetics; D043423:Carboxypeptidase H / Q000235:genetics; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics* / Q000662:veterinary*; D005796:Genes; D016678:Genome; D015894:Genome, Human; D006801:Humans; D008562:Membrane Glycoproteins / Q000235:genetics; D008565:Membrane Proteins / Q000235:genetics; D002679:Pan troglodytes; D054353:Perforin; D052899:Pore Forming Cytotoxic Proteins / Q000235:genetics; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1; D017027:Protein Tyrosine Phosphatases / Q000235:genetics; D054635:Receptor-Like Protein Tyrosine Phosphatases, Class 8
D001324:Autoantigens; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; D052899:Pore Forming Cytotoxic Proteins; D054353:Perforin; C516862:PTPRN protein, human; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1; D017027:Protein Tyrosine Phosphatases; D054635:Receptor-Like Protein Tyrosine Phosphatases, Class 8; D043423:Carboxypeptidase H