Asymmetric addition of 1-ethynylcyclohexene to both aromatic and heteroaromatic ketones catalyzed by a chiral Schiff base-zinc complex.
The evaluation of a chiral Schiff base ligand in the zinc-catalyzed asymmetric addition of 1-ethynylcyclohexene to both aromatic and heteroaromatic ketones is reported (with up to 83% enantioselectivity and up to 88% isolated yield).
Wang
Quan
Q
Department of Biochemistry and Molecular Biology, School of Life Sciences, and State key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, Gansu 730000, China.
Zhang
Bangzhi
B
Hu
Guowen
G
Chen
Chao
C
Zhao
Qinyang
Q
Wang
Rui
R
D000438:Alcohols / Q000138:chemical synthesis* / Q000737:chemistry; D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D003510:Cyclohexanes / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D008024:Ligands; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D013237:Stereoisomerism; D015032:Zinc / Q000737:chemistry*
D000438:Alcohols; D000480:Alkynes; D003510:Cyclohexanes; D007659:Ketones; D008024:Ligands; D009942:Organometallic Compounds; C522558:1-ethynylcyclohexene; D015032:Zinc