Facile synthesis of (+/-)-paeonilide.
(+/-)-Paeonilide, a novel monoterpenoid metabolite from the roots of Paeonia delavayi showing anti-platelet activating factor activity, is convergently synthesized in five steps with 59% overall yield. The application of benzoyl peroxide-promoted radical addition of unsaturated ester to aldehyde and subsequent topologically favored cyclization greatly simplified the synthesis.
Du
Yuguo
Y
State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China. duyuguo@rcees.ac.cn
Liu
Jun
J
Linhardt
Robert J
RJ
D005663:Furans / Q000737:chemistry*; D015394:Molecular Structure; D013729:Terpenes / Q000138:chemical synthesis* / Q000737:chemistry
D005663:Furans; D013729:Terpenes; C416702:paeonilide