Metabolic activity of cells in brain cortex after alcohol intoxication and correction of changes with Dolivin.
Metabolic processes in the brain cortex of albino rats with prenatal and postnatal alcohol intoxication were studied by the method of electron paramagnetic resonance. Accumulation of superoxide radical-generating agents, inactivation of superoxide dismutase, and increase in nitric oxide concentration were detected. Activation of free radical processes was associated with accumulation of Mn(2+)and Fe(2+). The parameters of electron paramagnetic resonance returned to normal after Dolivin treatment. These changes were accompanied by a decrease in the intensity of oxidative metabolism.
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I. S. Beritashvili Institute of Physiology, Georgian Academy of Sciences; Institute of Clinical and Experimental Medicine, Georgian State Medical University, Tbilisi. nanajaparidze2000@yahoo.com
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D000435:Alcoholic Intoxication / Q000378:metabolism*; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D002540:Cerebral Cortex / Q000166:cytology / Q000378:metabolism*; D004578:Electron Spin Resonance Spectroscopy; D005260:Female; D010647:Phenyl Ethers / Q000737:chemistry*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000378:metabolism; D051381:Rats; D012441:Saccharomyces cerevisiae / Q000737:chemistry*
D000975:Antioxidants; D010647:Phenyl Ethers; C085806:olifen