Impact of heart failure and left ventricular function on long-term survival--report of a community-based cohort study in Taiwan.
BACKGROUND
There is little community-based information on heart failure (HF) prognosis in ethnic Chinese populations, in whom there is a low prevalence of coronary heart disease.


OBJECTIVE
To study the impact of HF and left ventricular function on long-term all-cause mortality.


RESULTS
This community-based prospective cohort study included 2660 subjects (1215 men, 1445 women, mean age 54.4+/-11.9 years) over a 10 year follow-up period. The prevalence of HF was 5.5%. Hypertension was the most common factor related to HF. The five and ten year all-cause mortality was higher in the HF/preserved LVEF group (14.1% and 24.4%) and the HF/impaired LVEF group (29.2% and 48.2%) than in the HF-free group (6.0% and 14.6%, p<0.0001 for both). In multivariable Cox analyses, controlling for sex, LV mass, atrial fibrillation, hypertension, coronary heart disease, HF/preserved LVEF and HF/impaired LVEF were important predictors of all-cause mortality (p=0.007).


CONCLUSIONS
Hypertension is a major heart failure related disease. HF and LV systolic dysfunction are associated with a significant increase in all-cause mortality in an ethnic Chinese population.
Huang
Chien-Hua
CH
Department of Emergency Medicine, National Taiwan University Medical College and National Taiwan University Hospital, Taipei, Taiwan.
Chien
Kuo-Liong
KL
Chen
Wen-Jone
WJ
Sung
Fung-Chang
FC
Hsu
Hsiu-Ching
HC
Su
Ta-Chen
TC
Lee
Yuan-Teh
YT
D000328:Adult; D000368:Aged; D002423:Cause of Death; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D006333:Heart Failure / Q000401:mortality / Q000503:physiopathology*; D006801:Humans; D006973:Hypertension / Q000401:mortality / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D016019:Survival Analysis; D017741:Survivors; D013624:Taiwan; D018487:Ventricular Dysfunction, Left / Q000401:mortality / Q000503:physiopathology*