No association evidence between schizophrenia and dystrobrevin-binding protein 1 (DTNBP1) in Taiwanese families.
Several linkage studies have shown significant linkage of schizophrenia to chromosome 6p region, which includes the positional candidate genes, Dystrobrevin-binding protein 1 (DTNBP1). The aim was to examine the association evidence of the candidate gene in 693 Taiwanese families with at least two affected siblings of schizophrenia. We genotyped nine SNPs of this gene with average intermarker distance of 17 kb. Intermarker linkage disequilibrium was calculated with GOLD. Single locus and haplotype association analyses were performed with TRANSMIT program. We found no significant association between schizophrenia and DTNBP1 either through single locus or haplotype analyses. We failed to replicate the association evidence between DTNBP1 and schizophrenia and this gene may not play a major role in the etiology of schizophrenia in this Taiwanese family sample.
Liu
Chih-Min
CM
Department of Psychiatry, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
Liu
Yu-Li
YL
Fann
Cathy Shen-Jang
CS
Yang
Wei-Chih
WC
Wu
Jer-Yuarn
JY
Hung
Shuen-Iu
SI
Chen
Wei J
WJ
Chueh
Ching-Mo
CM
Liu
Wei-Ming
WM
Liu
Chen-Chung
CC
Hsieh
Ming-Hsien
MH
Hwang
Tzung-Jeng
TJ
Faraone
Stephen V
SV
Tsuang
Ming T
MT
Hwu
Hai-Gwo
HG
D000328:Adult; D044466:Asian People / Q000235:genetics*; D002352:Carrier Proteins / Q000235:genetics*; D002896:Chromosomes, Human, Pair 6; D000074765:Dysbindin; D049029:Dystrophin-Associated Proteins; D005260:Female; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000208:ethnology / Q000235:genetics*; D035781:Siblings / Q000523:psychology; D013624:Taiwan
D002352:Carrier Proteins; C432416:DTNBP1 protein, human; D000074765:Dysbindin; D049029:Dystrophin-Associated Proteins; D005819:Genetic Markers