Quantitative trait loci for fasting glucose in young Europeans replicate previous findings for type 2 diabetes in 2q23-24 and other locations.
Long before reaching diagnostic cutoff levels for type 2 diabetes, fasting glucose can be a powerful risk marker for this disease. We conducted a genome-wide search for fasting glucose as a quantitative trait in 412 young European sib-pairs including obese children, with adjustment for sex, age, and BMI. We identified more quantitative trait loci specific to fasting glucose and more significant than would be found by simple chance estimated by permutation tests. The strongest linkage was on chromosome 2q (logarithm of odds [LOD] = 3.00) in a region previously linked to type 2 diabetes as a disease. We also found linkage signals of fasting glucose with 7q (LOD = 2.03), 8q (1.28), 17p (2.12), 17q (1.4), and 11p (1.33). These findings suggest that the quantitative genetics of fasting glucose could contribute to the search for type 2 diabetes genes.
Fradin
Delphine
D
Department of Pediatric Endocrinology, Hôpital Saint-Vincent de Paul and U561 Institut National de la Santé et de la Recherche Médicale, Paris, France. fradin@paris5.inserm.fr
Heath
Simon
S
Lathrop
Mark
M
Bougnères
Pierre
P
D002648:Child; D002889:Chromosomes, Human, Pair 2; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D005006:Ethnicity; D005060:Europe; D005190:Family; D005260:Female; D015894:Genome, Human; D005838:Genotype; D006801:Humans; D008126:Lod Score; D008297:Male; D009765:Obesity / Q000235:genetics; D040641:Quantitative Trait Loci; D035781:Siblings