Aromatase expression was not detected by immunohistochemistry in endometrial cancer.
Several studies suggested that aromatase could play an important role in tumor progression and prognosis in endometrial cancer because androstenedione is converted to estrogen by the enzyme. For better understanding of the aromatase expression in endometrial cancer and its relation to diverse clinicopathological parameters, we conducted this study. This study was carried out with 141 endometrial cancer patients, all of whom had undergone operations in our institution from 1993 to 2002. Paraffin-embedded tissue blocks were sectioned and immunostained with monoclonal antiaromatase antibody using human placental tissue as positive control. Clinicopathological variables of all patients were also reviewed. Despite quite a high aromatase expression in positive control, there was no endometrial cancer specimen showing the enzyme expression. Our result, although needs further investigation on the cause of the difference from other studies, suggested that aromatase might not have an important role in endometrial cancer.
Jeon
Yong-Tark
YT
Department of Obstetrics and Gynecology, College of Medicine, Seoul National University, 28 Yungun-Dong, Jongno-Gu, Seoul 110-744, Korea. yssong@snu.ac.kr
Park
So Yeon
SY
Kim
Yong-Beom
YB
Kim
Jae Weon
JW
Park
Noh-Hyun
NH
Kang
Soon-Beom
SB
Lee
Hyo-Pyo
HP
Song
Yong-Sang
YS
D000328:Adult; D000368:Aged; D001141:Aromatase / Q000096:biosynthesis / Q000235:genetics* / Q000502:physiology; D014408:Biomarkers, Tumor / Q000235:genetics* / Q000502:physiology; D016889:Endometrial Neoplasms / Q000201:enzymology* / Q000235:genetics / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D010920:Placenta / Q000201:enzymology
D014408:Biomarkers, Tumor; D001141:Aromatase