Association of telomerase gene hTERT polymorphism and malignant gliomas.
BACKGROUND
The MNS16A polymorphism is located in the downstream region of the hTERT gene and affects telomerase activity.


METHODS
MNS16A has been investigated as a potential risk factor and/or prognostic marker for malignant glioma in a cohort of 352 patients (205 glioblastoma, 147 anaplastic gliomas) and 305 controls.


RESULTS
The S ("short") allele (which results in a higher telomerase activity) was significantly more frequent in glioma patients compared to the control population (278/704=39.5% vs. 200/610=32.8%; P=0.012). The odd ratios were 1 for LL (taken as reference), 1.33 [0.96; 1.84] for SL and 2.05 [1.22; 3.44] for SS. However, in contrast to a previous report, no significant difference of survival was found between SS, LL and SL allelotypes.


CONCLUSIONS
We found here the short allele of MNS16A more frequent in glioma patients, but it did not seem to be predictive of survival.
Carpentier
Catherine
C
INSERM, U711, Biologie des Interactions Neurones & Glie, Université Pierre et Marie Curie, Faculté de Médecine, and Service de Neurologie Mazarin, Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Pitié-Salpêtrière, Paris 13, France.
Lejeune
Julie
J
Gros
Florent
F
Everhard
Sibille
S
Marie
Yannick
Y
Kaloshi
Gentian
G
Laigle-Donadey
Florence
F
Hoang-Xuan
Khe
K
Delattre
Jean-Yves
JY
Sanson
Marc
M
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis; D001932:Brain Neoplasms / Q000235:genetics* / Q000401:mortality; D005260:Female; D020022:Genetic Predisposition to Disease; D005910:Glioma / Q000235:genetics* / Q000401:mortality; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011379:Prognosis; D019098:Telomerase / Q000235:genetics*
D014408:Biomarkers, Tumor; D019098:Telomerase