title: Plasma interleukin-8 as a potential predictor of mortality in adult patients with severe traumatic brain injury.
abstract: Because of complex pathophysiology and severe consequences, traumatic brain injuries (TBI) are an important medical problem. Pathophysiology of TBI includes local and systemic stress response, in which interleukin-8 (IL-8) is considered as a key mediator of neuroinflammation. However, prognostic relevance of IL-8 measurement in adult patients with severe TBI is not certain. Therefore, IL-8 was determined in blood samples from central venous and jugular bulb catheter and in cerebrospinal fluid of twenty patients with isolated TBI at admission to Intensive Care Unit. None of the patients had history of stroke, dementia, autoimmune diseases, acute infection or medication with anti-inflammatory drugs. Ten patients died due to traumatic brain injury, while the other ten recovered well. While there was no significant difference of IL-8 levels in cerebrospinal fluid between survivors and nonsurvivors, central venous plasma level of IL-8 was significantly lower in survivors (71.00 +/- 14.17 pg/ml), than in nonsurvivors (111.26 +/- 16.9 pg/ml). Receiver Operating Characteristic (ROC) analysis revealed significant prognostic value for IL-8 in the blood as well as for the age of patients, Glasgow Coma Scale (GCS) and Acute Physiologic and Chronic Health Evaluation (APACHE II). These findings suggest that the central venous plasma values of IL-8 at admission might be an early predictive marker in patients with severe TBI, comparative to standard clinical prognostic markers such as APACHE II and GCS.
authors.affiliation: Department of Anesthesiology and Intensive Care, University Hospital Sestre Milosrdnice, Zagreb, Croatia.
authors.forename: Aleksandar
authors.initials: A
authors.lastname: Gopcevic
authors.forename: Branka
authors.initials: B
authors.lastname: Mazul-Sunko
authors.forename: Jasminka
authors.initials: J
authors.lastname: Marout
authors.forename: Ante
authors.initials: A
authors.lastname: Sekulic
authors.forename: Natasa
authors.initials: N
authors.lastname: Antoljak
authors.forename: Mladen
authors.initials: M
authors.lastname: Siranovic
authors.forename: Zeljko
authors.initials: Z
authors.lastname: Ivanec
authors.forename: Marko
authors.initials: M
authors.lastname: Margaritoni
authors.forename: Miroslav
authors.initials: M
authors.lastname: Bekavac-Beslin
authors.forename: Neven
authors.initials: N
authors.lastname: Zarkovic
mesh_terms: D018806:APACHE; D000328:Adult; D015415:Biomarkers / Q000097:blood; D001930:Brain Injuries / Q000097:blood / Q000276:immunology* / Q000401:mortality*; D005260:Female; D015600:Glasgow Coma Scale; D006801:Humans; D016209:Interleukin-8 / Q000097:blood* / Q000134:cerebrospinal fluid; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012372:ROC Curve
chemical_list: D015415:Biomarkers; D016209:Interleukin-8