An elderly case of type 2 diabetes which developed in association with oral and esophageal candidiasis.
A 75-year-old woman who had been healthy except for mild glycemia and lipidemia discovered three and a half months before admission experienced severe dysphagia secondary to oral and esophageal candidiasis. She eventually developed diabetic hyperosmolar syndrome and ketoacidosis. Since anti-GAD antibody was negative and her diabetes was controlled with a moderate dose of insulin, we made a diagnosis of type 2 diabetes. Her only risk factors for candidiasis were hyperglycemia, age, and continuous denture use. The fact that her diabetes developed in association with oral candidiasis supports the hypothesis that there is a bidirectional interrelationship between diabetes and oral infection.
Takasawa
Hirofumi
H
Department of Endocrinology and Metabolism, International Medical Center of Japan, Tokyo, Japan.
Takahashi
Yoshihiko
Y
Abe
Makiko
M
Osame
Keiichiro
K
Watanabe
Shigeru
S
Hisatake
Tomoko
T
Yasuda
Kazuki
K
Kaburagi
Yasushi
Y
Kajio
Hiroshi
H
Noda
Mitsuhiko
M
D000368:Aged; D000935:Antifungal Agents / Q000627:therapeutic use; D002180:Candidiasis, Oral / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D004935:Esophageal Diseases / Q000150:complications* / Q000188:drug therapy / Q000382:microbiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D018570:Risk Assessment; D012720:Severity of Illness Index
D000935:Antifungal Agents; D007004:Hypoglycemic Agents