title: Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24.
abstract: Prostate cancer is the most prevalent noncutaneous cancer in males in developed regions, with African American men having among the highest worldwide incidence and mortality rates. Here we report a second genetic variant in the 8q24 region that, in conjunction with another variant we recently discovered, accounts for about 11%-13% of prostate cancer cases in individuals of European descent and 31% of cases in African Americans. We made the current discovery through a genome-wide association scan of 1,453 affected Icelandic individuals and 3,064 controls using the Illumina HumanHap300 BeadChip followed by four replication studies. A key step in the discovery was the construction of a 14-SNP haplotype that efficiently tags a relatively uncommon (2%-4%) susceptibility variant in individuals of European descent that happens to be very common (approximately 42%) in African Americans. The newly identified variant shows a stronger association with affected individuals who have an earlier age at diagnosis.
authors.affiliation: deCODE genetics, Sturlugata 8, 101 Reykjavik, Iceland.
authors.forename: Julius
authors.initials: J
authors.lastname: Gudmundsson
authors.forename: Patrick
authors.initials: P
authors.lastname: Sulem
authors.forename: Andrei
authors.initials: A
authors.lastname: Manolescu
authors.forename: Laufey T
authors.initials: LT
authors.lastname: Amundadottir
authors.forename: Daniel
authors.initials: D
authors.lastname: Gudbjartsson
authors.forename: Agnar
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authors.lastname: Helgason
authors.forename: Thorunn
authors.initials: T
authors.lastname: Rafnar
authors.forename: Jon T
authors.initials: JT
authors.lastname: Bergthorsson
authors.forename: Bjarni A
authors.initials: BA
authors.lastname: Agnarsson
authors.forename: Adam
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authors.lastname: Baker
authors.forename: Asgeir
authors.initials: A
authors.lastname: Sigurdsson
authors.forename: Kristrun R
authors.initials: KR
authors.lastname: Benediktsdottir
authors.forename: Margret
authors.initials: M
authors.lastname: Jakobsdottir
authors.forename: Jianfeng
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authors.lastname: Xu
authors.forename: Thorarinn
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authors.lastname: Blondal
authors.forename: Jelena
authors.initials: J
authors.lastname: Kostic
authors.forename: Jielin
authors.initials: J
authors.lastname: Sun
authors.forename: Shyamali
authors.initials: S
authors.lastname: Ghosh
authors.forename: Simon N
authors.initials: SN
authors.lastname: Stacey
authors.forename: Magali
authors.initials: M
authors.lastname: Mouy
authors.forename: Jona
authors.initials: J
authors.lastname: Saemundsdottir
authors.forename: Valgerdur M
authors.initials: VM
authors.lastname: Backman
authors.forename: Kristleifur
authors.initials: K
authors.lastname: Kristjansson
authors.forename: Alejandro
authors.initials: A
authors.lastname: Tres
authors.forename: Alan W
authors.initials: AW
authors.lastname: Partin
authors.forename: Marjo T
authors.initials: MT
authors.lastname: Albers-Akkers
authors.forename: Javier
authors.initials: J
authors.lastname: Godino-Ivan Marcos
authors.forename: Patrick C
authors.initials: PC
authors.lastname: Walsh
authors.forename: Dorine W
authors.initials: DW
authors.lastname: Swinkels
authors.forename: Sebastian
authors.initials: S
authors.lastname: Navarrete
authors.forename: Sarah D
authors.initials: SD
authors.lastname: Isaacs
authors.forename: Katja K
authors.initials: KK
authors.lastname: Aben
authors.forename: Theresa
authors.initials: T
authors.lastname: Graif
authors.forename: John
authors.initials: J
authors.lastname: Cashy
authors.forename: Manuel
authors.initials: M
authors.lastname: Ruiz-Echarri
authors.forename: Kathleen E
authors.initials: KE
authors.lastname: Wiley
authors.forename: Brian K
authors.initials: BK
authors.lastname: Suarez
authors.forename: J Alfred
authors.initials: JA
authors.lastname: Witjes
authors.forename: Mike
authors.initials: M
authors.lastname: Frigge
authors.forename: Carole
authors.initials: C
authors.lastname: Ober
authors.forename: Eirikur
authors.initials: E
authors.lastname: Jonsson
authors.forename: Gudmundur V
authors.initials: GV
authors.lastname: Einarsson
authors.forename: Jose I
authors.initials: JI
authors.lastname: Mayordomo
authors.forename: Lambertus A
authors.initials: LA
authors.lastname: Kiemeney
authors.forename: William B
authors.initials: WB
authors.lastname: Isaacs
authors.forename: William J
authors.initials: WJ
authors.lastname: Catalona
authors.forename: Rosa B
authors.initials: RB
authors.lastname: Barkardottir
authors.forename: Jeffrey R
authors.initials: JR
authors.lastname: Gulcher
authors.forename: Unnur
authors.initials: U
authors.lastname: Thorsteinsdottir
authors.forename: Augustine
authors.initials: A
authors.lastname: Kong
authors.forename: Kari
authors.initials: K
authors.lastname: Stefansson
mesh_terms: D001741:Black or African American; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics*; D005060:Europe; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D014644:Genetic Variation; D023281:Genomics / Q000379:methods; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D011471:Prostatic Neoplasms / Q000235:genetics*; D014481:United States; D044465:White People