[Functional state of the vessel endothelium in patients with systemic lupus erythematosis].
SLE patients show the formation of endothelial dysfunction manifested by the decreuse of endothelial dependent vasodilatation in response to reactive hyperemia test and incapuse of carotid artery intima-media thickness (IMT). Disorder of Endothelial dependent vasodilation damage in SLE patients is associated with age, damage index and inflammatory process activity. An association with the duration of the disease was not been found. (IMT) thickness increase is associated with the age, damage index and has no correlation with the duration of the disease. The rate of atherosclerotic plaques in the carotid artery in SLE patients exceeds by 1.8 times that of the control group. Atherosclerotic identification rate was found to have tight association with age, disease activity and damage index. Atherosclerotic damage degree is associated with damage index and disease activity and has no correlation with age and the duration of the disease.
Shevchuk
S V
SV
Stanislavchuk
M A
MA
D000328:Adult; D000367:Age Factors; D001161:Arteriosclerosis / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D002339:Carotid Arteries / Q000473:pathology / Q000503:physiopathology; D004730:Endothelium, Vascular / Q000473:pathology / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D017539:Tunica Intima / Q000473:pathology / Q000503:physiopathology; D014664:Vasodilation / Q000502:physiology*