title: Early impairment of synaptic plasticity in patients with Down's syndrome.
abstract: We investigated synaptic plasticity in persons with Down' syndrome (DS) and control subjects used paired associative stimulation (PAS) protocol, a paradigm capable of producing long-term potentiation (LTP)-like changes in the sensorimotor system. After PAS, patients showed less LTP-like plasticity compared to control subjects. Abnormal motor cortex synaptic plasticity may play a role in the development of motor signs in DS.
authors.affiliation: CUNY School of Medicine, Department of Physiology and Pharmacology, 138th Street & Convent Avenue, Room D-210, New York, NY 10031, United States. fb@med.cuny.edu
authors.forename: Fortunato
authors.initials: F
authors.lastname: Battaglia
authors.forename: Angelo
authors.initials: A
authors.lastname: Quartarone
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Rizzo
authors.forename: Maria Felice
authors.initials: MF
authors.lastname: Ghilardi
authors.forename: Alessandro
authors.initials: A
authors.lastname: Di Rocco
authors.forename: Gaetano
authors.initials: G
authors.lastname: Tortorella
authors.forename: Paolo
authors.initials: P
authors.lastname: Girlanda
mesh_terms: D000293:Adolescent; D002540:Cerebral Cortex / Q000503:physiopathology*; D004314:Down Syndrome / Q000503:physiopathology*; D005260:Female; D006801:Humans; D017774:Long-Term Potentiation; D008297:Male; D009473:Neuronal Plasticity; D009435:Synaptic Transmission