title: Clinical pharmacokinetics of oseltamivir and its active metabolite oseltamivir carboxylate after oral administration in horses.
abstract: The aim of this study was to investigate the pharmacokinetics of oseltamivir carboxylate (OC) in horses (n=6) after oral administration of its prodrug oseltamivir. The binding rate of OC to horse plasma proteins was negligible (<1%). Oral administration of oseltamivir of 2 mg/kg body weight of oseltamivir to horses provided a plasma concentration of OC (mean maximum concentration: 257.9 ng/ml) above the inhibitory concentrations against equine influenza A viruses determined in vitro. However, because OC is rapidly eliminated from horse plasma (mean elimination half-life: 2.5 hr), administration intervals should be less than 10 hr to retain a suitable concentration when using a single dose of 2 mg/kg oseltamivir.
authors.affiliation: Epizootic Research Center, Equine Research Institute, Japan Racing Association, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Yamanaka
authors.forename: Masayuki
authors.initials: M
authors.lastname: Yamada
authors.forename: Koji
authors.initials: K
authors.lastname: Tsujimura
authors.forename: Takashi
authors.initials: T
authors.lastname: Kondo
authors.forename: Shunichi
authors.initials: S
authors.lastname: Nagata
authors.forename: Seiji
authors.initials: S
authors.lastname: Hobo
authors.forename: Masahiko
authors.initials: M
authors.lastname: Kurosawa
authors.forename: Tomio
authors.initials: T
authors.lastname: Matsumura
mesh_terms: D000284:Administration, Oral; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D006734:Horse Diseases / Q000188:drug therapy; D006736:Horses; D008297:Male; D015394:Molecular Structure; D009976:Orthomyxoviridae Infections / Q000188:drug therapy / Q000662:veterinary; D053139:Oseltamivir / Q000008:administration & dosage / Q000097:blood* / Q000378:metabolism / Q000493:pharmacokinetics*; D011355:Prodrugs / Q000008:administration & dosage / Q000378:metabolism / Q000493:pharmacokinetics*; D013997:Time Factors
chemical_list: D011355:Prodrugs; D053139:Oseltamivir