Surgical treatment of pulmonary metastasis from hepatocellular carcinoma.
OBJECTIVE
The lung is one of the most common sites of extrahepatic spread from hepatocellular carcinoma (HCC). The aim of this study was to evaluate the efficacy of surgical management in patients with pulmonary metastasis from HCC.


METHODS
Fourteen patients with pulmonary metastases arising from HCC underwent surgery at the National Cancer Center Hospital between 1980 and 2001. The clinical and pathological data were analyzed retrospectively.


RESULTS
Four patients were still alive and none of them had evidence of recurrent disease. Ten patients had died with recurrent HCC. The postoperative morbidity and mortality rates were low. The mean overall survival was 42.7 months (range, 8-87). The mean survival after initial thoracotomy was 21.6 months (range, 1-66). The 1-, 2-, and 5-year survival rates after metastasectomy were 71.4%, 44.6%, and 26.8%, respectively.


CONCLUSIONS
Surgical treatment is appropriate option in selected patients for pulmonary metastasis arising from HCC, and might prolong survival.
Koide
Norimasa
N
Division of Thoracic Surgery, National Cancer Center Hospital, Japan.
Kondo
Haruhiko
H
Suzuki
Kenji
K
Asamura
Hisao
H
Shimada
Kazuaki
K
Tsuchiya
Ryosuke
R
D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000401:mortality / Q000556:secondary* / Q000628:therapy; D016461:Chemoembolization, Therapeutic; D003131:Combined Modality Therapy; D000431:Ethanol / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology* / Q000628:therapy; D008175:Lung Neoplasms / Q000401:mortality / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011013:Pneumonectomy / Q000379:methods; D011379:Prognosis; D012189:Retrospective Studies; D020775:Thoracic Surgery, Video-Assisted
D000431:Ethanol