title: Enhanced antitumor activity of irinotecan combined with propolis and its polyphenolic compounds on Ehrlich ascites tumor in mice.
abstract: The effects of the anticancer drug irinotecan combined with ethanolic extract of propolis (EEP), a water-soluble derivate of propolis (WSDP), quercetin and naringin on the growth of Ehrlich ascites tumor (EAT) and the life span of tumor-bearing Swiss albino mice were studied. Test components were given to mice intraperitoneally (i.p.) at doses of 100mg kg(-1) for three consecutive days before the i.p. injection of EAT cells (1x10(6)). Irinotecan was administered i.p. at dose of 50mg kg(-1) on days 1, 13, and 19 after tumor cell inoculation. The results clearly demonstrate the synergistic action of irinotecan and EEP on survival time. These results suggest that clinical trials using a propolis preparation EEP combined with irinotecan may be beneficial in maximizing antitumor activity and minimizing post-chemotherapeutic reactions to the cytostatic drug.
authors.affiliation: Department of Animal Physiology, Faculty of Science, University of Zagreb, Rooseveltov trg 6, 10000 Zagreb, Croatia.
authors.forename: V
authors.initials: V
authors.lastname: Benkovic
authors.forename: A
authors.initials: A
authors.lastname: Horvat Knezevic
authors.forename: G
authors.initials: G
authors.lastname: Brozovic
authors.forename: F
authors.initials: F
authors.lastname: Knezevic
authors.forename: D
authors.initials: D
authors.lastname: Dikic
authors.forename: M
authors.initials: M
authors.lastname: Bevanda
authors.forename: I
authors.initials: I
authors.lastname: Basic
authors.forename: N
authors.initials: N
authors.lastname: Orsolic
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000627:therapeutic use*; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy*; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D044950:Flavanones / Q000008:administration & dosage / Q000627:therapeutic use; D005419:Flavonoids / Q000008:administration & dosage / Q000627:therapeutic use*; D000077146:Irinotecan; D008297:Male; D051379:Mice; D010636:Phenols / Q000008:administration & dosage / Q000627:therapeutic use*; D059808:Polyphenols; D011429:Propolis / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D011794:Quercetin / Q000008:administration & dosage / Q000627:therapeutic use
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D044950:Flavanones; D005419:Flavonoids; D010636:Phenols; D059808:Polyphenols; D000077146:Irinotecan; D011429:Propolis; D011794:Quercetin; C005274:naringin; D002166:Camptothecin