title: Role of surfactants in clouding phenomenon of imipramine hydrochloride.
abstract: The clouding behavior of tricyclic antidepressant drug imipramine hydrochloride (IMP) in aqueous solution has been studied in presence of surfactants. A pH increase in the presence as well as in the absence of surfactants decreased the CP. Drug molecules become neutral at high pH and therefore head-head repulsion decreases which lead to CP decrease. Addition of non-ionic and cationic surfactants increased the CP whereas anionic surfactants showed a peaked profile. Effect of CTAB/TX-100 at different fixed drug concentrations showed that at all surfactant concentrations the CP value was higher for higher drug concentrations. However, variation of pH produced opposite effect: CP at all CTAB/TX-100 concentrations decreased with increasing pH. All results are interpreted in terms of increase in hydrophobicity or hydrophilicity of micelles on addition of surfactants.
authors.affiliation: Department of Chemistry, Aligarh Muslim University, Aligarh 202002, UP, India.
authors.forename: Md Sayem
authors.initials: MS
authors.lastname: Alam
authors.forename: Andleeb Z
authors.initials: AZ
authors.lastname: Naqvi
authors.lastname: Kabir-Ud-Din
mesh_terms: D000929:Antidepressive Agents, Tricyclic / Q000737:chemistry*; D007099:Imipramine / Q000737:chemistry*; D013501:Surface-Active Agents / Q000737:chemistry*
chemical_list: D000929:Antidepressive Agents, Tricyclic; D013501:Surface-Active Agents; D007099:Imipramine