title: [Changes of heme oxygenase-1 and inflammatory factors in patients with end-stage renal failure following hemodialysis].
abstract: OBJECTIVE
  To evaluate the changes in heme oxygenase-1 (HO-1), C-reactive protein (CRP), interleukin-6 (IL-6), and malondialdehyde (MDA) levels in patients with end-stage renal failure (ESRF) following hemodialysis.
  
  
  METHODS
  The urea nitrogen and the blood creatinine levels were determined with an automatic biochemistry analyzer, HO-1 and IL-6 levels by enzyme linked immunosorbent assay (ELISA), CRP by chemoluminescence technique, and MDA by thiobarbituric acid assay.
  
  
  RESULTS
  HO-1, CRP, IL-6, and MDA levels were significantly elevated in patients with ESRF in comparison with the control group. After hemodialysis, HO-1 and CRP levels increased and IL-6 and MDA levels decreased significantly.
  
  
  CONCLUSIONS
  In ESRF patients who have elevated inflammatory factors and HO-1 levels, hemodialysis can increase HO-1 and CRP levels and lower IL-6 and MDA levels.
authors.affiliation: Southern Medical University, Guangzhou 510515, China. fanwu112@163.com
authors.forename: Fan
authors.initials: F
authors.lastname: Wu
authors.forename: Lu
authors.initials: L
authors.lastname: Yu
authors.forename: Zhi-min
authors.initials: ZM
authors.lastname: Zhang
authors.forename: Hai-bin
authors.initials: HB
authors.lastname: Shi
mesh_terms: D000328:Adult; D001806:Blood Urea Nitrogen; D002097:C-Reactive Protein / Q000378:metabolism*; D003404:Creatinine / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D051547:Heme Oxygenase-1 / Q000097:blood*; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D007676:Kidney Failure, Chronic / Q000097:blood / Q000628:therapy*; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D006435:Renal Dialysis
chemical_list: D015850:Interleukin-6; D008315:Malondialdehyde; D002097:C-Reactive Protein; D003404:Creatinine; D051547:Heme Oxygenase-1