title: Carbonarones A and B, new bioactive gamma-Pyrone and alpha-Pyridone derivatives from the marine-derived fungus Aspergillus carbonarius.
abstract: Two new secondary metabolites, carbonarones A (1) and B (2), were obtained from the culture of the marine-derived fungus Aspergillus carbonarius isolated from the marine sediment collected at Weizhou island of China. Based on ESIMS, 1D and 2D NMR data, and the X-ray crystallographic analysis, their structures were elucidated as 6-benzyl-4-oxo-4H-pyran-3-carboxamide and 6-benzyl-4-hydroxy-2-oxo-1, 2-dihydropyridine-3-carbaldehyde, respectively. 1 and 2 showed moderate cytotoxicity against K562 cells with IC(50) values of 56.0 and 27.8 mug/ml, respectively.
authors.affiliation: Key Laboratory of Marine Drugs, Ministry of Education, Institute of Marine Drugs and Food, Ocean University of China, Qingdao, PR China.
authors.forename: Yapeng
authors.initials: Y
authors.lastname: Zhang
authors.forename: Tianjiao
authors.initials: T
authors.lastname: Zhu
authors.forename: Yuchun
authors.initials: Y
authors.lastname: Fang
authors.forename: Hongbing
authors.initials: H
authors.lastname: Liu
authors.forename: Qianqun
authors.initials: Q
authors.lastname: Gu
authors.forename: Weiming
authors.initials: W
authors.lastname: Zhu
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis* / Q000302:isolation & purification / Q000494:pharmacology; D001230:Aspergillus / Q000737:chemistry / Q000378:metabolism*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002851:Chromatography, High Pressure Liquid; D018360:Crystallography, X-Ray; D003470:Culture Media / Q000032:analysis; D004354:Drug Screening Assays, Antitumor; D005285:Fermentation; D006801:Humans; D020014:K562 Cells; D009682:Magnetic Resonance Spectroscopy; D025282:Mycelium / Q000737:chemistry; D009792:Oceans and Seas; D011728:Pyridones / Q000302:isolation & purification / Q000378:metabolism* / Q000494:pharmacology; D011753:Pyrones / Q000302:isolation & purification / Q000378:metabolism* / Q000494:pharmacology
chemical_list: D000903:Antibiotics, Antineoplastic; D003470:Culture Media; D011728:Pyridones; D011753:Pyrones; C519863:carbonarone A; C519864:carbonarone B