trans-(1R,2R)-Diaminocyclohexane-functionalized mesoporous organosilica spheres as chiral stationary phase.
The bifunctionalized mesoporous organosilica spheres with trans-(1R,2R)-diaminocyclohexane (DACH) in the pore were synthesized and their application as chiral stationary phase in high-performance liquid chromatography (HPLC) was demonstrated. Bifunctionalized mesoporous organosilica spheres with narrow particle size distribution of 5-7 microm were prepared by the co-condensation of N-[3-(triethoxysilyl)propyl]-trans-(1R,2R)-diaminocyclohexane (M(propyl)) with 1,2-bis(trimethoxysilyl)ethane (BTME) in basic medium using octadecyltrimethylammonium chloride (C(18)TACl) as structural directing agent and ethanol as co-solvent. The morphologies of the bifunctionalized mesoporous organosilicas were sensitive to the molar fraction of M(propyl). At higher M(propyl)/BTME molar ratio, the bifunctionalized organosilica spheres with ordered mesoporous structure can be formed in a wide range of synthetic conditions. When the molar percent of M(propyl)/(M(propyl)+BTME) is less than 20, the formation of spheres could be hardly observed. The structural order of the materials mainly depends on the base concentration and M(propyl)/BTME molar ratio in the initial sol mixture. A column packed with the bifunctionalized mesoporous organosilica spheres exhibits higher selectivity and resolution for racemic amino acids than that packed with DACH-SiO(2) prepared by conventional post-synthesis grafting method.
Zhu
Guiru
G
State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, China.
Jiang
Dongmei
D
Yang
Qihua
Q
Yang
Jie
J
Li
Can
C
D002851:Chromatography, High Pressure Liquid; D003510:Cyclohexanes / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D010316:Particle Size; D012822:Silicon Dioxide / Q000737:chemistry*; D013237:Stereoisomerism
D003510:Cyclohexanes; D012822:Silicon Dioxide