title: Event-related potentials (P300) and neuropsychological assessment in boys exhibiting Duchenne muscular dystrophy.
abstract: OBJECTIVE
  To examine auditory cognitive evoked potentials (P300 potentials) and neuropsychological dysfunction in patients with Duchenne muscular dystrophy (DMD).
  
  
  METHODS
  P300 potentials and neuropsychological test results were obtained from 16 healthy control boys and 20 DMD patients. Full Intelligence Quotients (IQ) were estimated for patients and control group. Mean age was 9.5 years in the DMD patient group, and 10 years in the control group (p>0.05).
  
  
  RESULTS
  The mean IQ values were 64.35 in the DMD patients and 82.68 in the control group (p=0.01). Mean P300 values were 347.6 in the DMD group and 337.4 in the control group (p=0.14). There was no significant correlation between parameters in each group.
  
  
  CONCLUSIONS
  DMD patients showed a poor performance as evaluated by P300 potential compared to the control group, although the difference was not statistically significant. Systematic alterations in neuropsychological test results were found, the differences paralleling those detected in IQ.
authors.affiliation: Neuromuscular/Neurology Division, Internal Medicine Department, Hospital de Clínicas, Universidade Federal do Paraná, Rua General Carneiro 181, 80060-900 Curitiba, PR, Brazil. neurocoletta@hotmail.com
authors.forename: Marcus Vinicius
authors.initials: MV
authors.lastname: Della Coletta
authors.forename: Rosana Herminia
authors.initials: RH
authors.lastname: Scola
authors.forename: Gislaine Richter Minhoto
authors.initials: GR
authors.lastname: Wiemes
authors.forename: Cláudia Nasser
authors.initials: CN
authors.lastname: Fonseca
authors.forename: Maria Joana
authors.initials: MJ
authors.lastname: Mäder
authors.forename: Aline Andrade
authors.initials: AA
authors.lastname: Freund
authors.forename: Lineu César
authors.initials: LC
authors.lastname: Werneck
mesh_terms: D000293:Adolescent; D016022:Case-Control Studies; D002648:Child; D003072:Cognition Disorders / Q000503:physiopathology*; D018913:Event-Related Potentials, P300 / Q000502:physiology*; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D006801:Humans; D008297:Male; D020388:Muscular Dystrophy, Duchenne / Q000503:physiopathology*; D009483:Neuropsychological Tests; D014888:Wechsler Scales