Cutaneous intralymphatic histiocytosis associated with rheumatoid arthritis: report of a case and review of the literature.
Various dermatoses have been described associated with rheumatoid arthritis. Recently, a specific cutaneous lesion termed "intravascular histiocytosis" has been proposed as a new entity among these dermatoses. We report the case of a 50-year-old woman with rheumatoid arthritis for about 10 years who developed erythematous patches on the extensor surface of lower extremities. Histopathologically, the lesions showed intraluminal proliferation of CD68-positive histiocytes in vessels lined with endothelial cells expressing D2-40, a selective marker for lymphatic endothelium.
Catalina-Fernández
Inmaculada
I
Department of Pathology, Hospital Universitario Perpetuo Socorro-Materno Infantil, Badajoz, Spain. yaye@eresmas.net
Alvárez
Antonio Chaves
AC
Martin
Félix Conde
FC
Fernández-Mera
Jose Juan
JJ
Sáenz-Santamaría
Javier
J
D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D015703:Antigens, CD / Q000032:analysis; D015214:Antigens, Differentiation, Myelomonocytic / Q000032:analysis; D001172:Arthritis, Rheumatoid / Q000150:complications* / Q000276:immunology / Q000473:pathology; D049109:Cell Proliferation; D020405:Dermis / Q000276:immunology / Q000473:pathology; D004890:Erythema / Q000209:etiology / Q000276:immunology; D005260:Female; D006644:Histiocytes / Q000276:immunology / Q000473:pathology; D015614:Histiocytosis / Q000175:diagnosis / Q000209:etiology / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods*; D007868:Leg Dermatoses / Q000175:diagnosis / Q000209:etiology / Q000276:immunology* / Q000473:pathology; D042601:Lymphatic Vessels / Q000276:immunology* / Q000473:pathology; D008875:Middle Aged; D000097382:CD68 Molecule
D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; C067980:CD68 antigen, human; D000097382:CD68 Molecule; C500987:monoclonal antibody D2-40