Niemann-Pick C proteins in sterol transport and absorption: flies in the ointment.
The Niemann-Pick C proteins have slowly emerged as regulators of subcellular lipid transport and sterol absorption at the small intestine. A recent article in Cell Metabolism suggests that in addition to their significant structural and sequence homology, these proteins may orchestrate their functions in a previously unappreciated fashion (Voght et al., 2007).
Ioannou
Yiannis A
YA
Department of Genetics and Genomic Sciences, Box 1498, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA. Yiannis.Ioannou@mssm.edu
D000042:Absorption; D000818:Animals; D001692:Biological Transport; D002784:Cholesterol / Q000493:pharmacokinetics; D004331:Drosophila melanogaster / Q000378:metabolism*; D051379:Mice; D008954:Models, Biological; D009542:Niemann-Pick Diseases / Q000378:metabolism*; D013261:Sterols / Q000493:pharmacokinetics*
D013261:Sterols; D002784:Cholesterol