Pancreatic lipase-inhibiting triterpenoid saponins from Gypsophila oldhamiana.
Three new triterpenoid saponins, gypsosaponins A-C (1-3), were isolated from the roots of Gypsophila oldhamiana (Caryophyllaceae). Their structures were established as 3-O-beta-D-galactopyranosyl-(1-->2)-[beta-D-xylopyranosyl-(1-->3)]-beta-D-glucuronopyranosyl quillaic acid 28-O-alpha-L-arabinopyranosyl-(1-->2)-alpha-L-arabinopyranosyl-(1-->3)-beta-D-xylopyranosyl-(1-->4)-alpha-L-rhamnopyranosyl-(1-->2)-beta-D-fucopyranoside (1), 3-O-beta-D-galactopyranosyl-(1-->2)-[beta-D-xylopyranosyl-(1-->3)]-methyl-beta-D-glucuronopyranosyl gypsogenin 28-O-beta-D-glucopyranosyl-(1-->3)-[beta-D-xylopyranosyl-(1-->4)]-alpha-L-rhamnopyranosyl-(1-->2)-beta-D-fucopyranoside (2), and 23-O-beta-D-glucopyranosyl gypsogenic acid 28-O-beta-D-glucopyranosyl-(1-->3)-[beta-D-glucopyranosyl-(1-->6)]-beta-D-glucopyranoside (3), on the basis of various spectroscopic analyses and chemical degradations. The biological activities of 1-3 were examined inhibitory activity against pancreatic lipase, which showed inhibition of 58.2%, 99.2% and 50.3% at concentration of 1 mg/ml, respectively.
Zheng
Quan
Q
Faculty of Pharmaceutical Sciences, Toho University, Chiba, Japan.
Li
Wei
W
Han
Likun
L
Koike
Kazuo
K
D029748:Caryophyllaceae / Q000737:chemistry*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D008049:Lipase / Q000037:antagonists & inhibitors*; D009682:Magnetic Resonance Spectroscopy; D010179:Pancreas / Q000201:enzymology*; D012503:Saponins / Q000494:pharmacology*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D014315:Triterpenes / Q000494:pharmacology*
D004791:Enzyme Inhibitors; D012503:Saponins; D014315:Triterpenes; D008049:Lipase