title: Intracellular motility: myosin and tropomyosin in actin cable flow.
abstract: A new study has found that retrograde flow of budding yeast actin cables is facilitated by myosin II but is inhibited by a specific tropomyosin isoform (Tpm2p). Budding yeast therefore contains a minimal component system for elucidating the mechanistic details of retrograde actin flow.
authors.affiliation: Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago, IL 60637, USA. drkovar@uchicago.edu
authors.forename: David R
authors.initials: DR
authors.lastname: Kovar
mesh_terms: D000199:Actins / Q000378:metabolism*; D000818:Animals; D009068:Movement; D024462:Myosin Type II / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000737:chemistry / Q000166:cytology / Q000502:physiology*; D014335:Tropomyosin / Q000378:metabolism*
chemical_list: D000199:Actins; D014335:Tropomyosin; D024462:Myosin Type II