title: Synthesis of a fluorous ligand and its application for asymmetric addition of dimethylzinc to aldehydes.
abstract: A new fluorous ligand was synthesized from the acetonide of dimethyl tartarate, which showed excellent asymmetric induction on the addition of dimethylzinc to aldehydes. This ligand will be useful for synthesis of bioactive compounds with a methyl carbinol moiety. It could be recycled without using a fluorous solvent or a fluorous column.
authors.affiliation: Faculty of Pharmaceutical Sciences, Setsunan University, Hirakata, Japan.
authors.forename: Yasser S
authors.initials: YS
authors.lastname: Sokeirik
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Mori
authors.forename: Masaaki
authors.initials: M
authors.lastname: Omote
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Sato
authors.forename: Atsushi
authors.initials: A
authors.lastname: Tarui
authors.forename: Itsumaro
authors.initials: I
authors.lastname: Kumadaki
authors.forename: Akira
authors.initials: A
authors.lastname: Ando
mesh_terms: D000447:Aldehydes / Q000138:chemical synthesis* / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid; D004148:Dioxolanes / Q000737:chemistry; D017611:Fluorine Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D008024:Ligands; D000432:Methanol / Q000031:analogs & derivatives / Q000737:chemistry; D008745:Methylation; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D004148:Dioxolanes; D017611:Fluorine Compounds; D008024:Ligands; D009942:Organometallic Compounds; C516101:alpha,alpha,alpha',alpha'-tetraaryl-1,3-dioxolane-4,5-dimethanol; C511262:dimethylzinc; D000432:Methanol