title: Dissemination of Acinetobacter baumannii clones with OXA-23 Carbapenemase in Colombian hospitals.
abstract: During 2005, 66 carbapenem-resistant isolates of Acinetobacter baumannii were collected from seven tertiary-care hospitals participating in a nationwide surveillance network in Colombia. The isolates were multidrug resistant and produced the carbapenemases OXA-23 and OXA-51. Forty-five belonged to four clones while 21 were unique pulsotypes. One clone was present in two hospitals within one city, while another had spread between two hospitals in different cities. Blood, secretions, and abdominal fluids were the most frequent sites of isolation. This is the first description of widespread dissemination of OXA-23 in South America.
authors.affiliation: John Stroger Hospital, 1900 W. Polk, Rm. 1236, Chicago, IL 60612, USA.
authors.forename: Maria Virginia
authors.initials: MV
authors.lastname: Villegas
authors.forename: Juan Nicolas
authors.initials: JN
authors.lastname: Kattan
authors.forename: Adriana
authors.initials: A
authors.lastname: Correa
authors.forename: Karen
authors.initials: K
authors.lastname: Lolans
authors.forename: Ana Maria
authors.initials: AM
authors.lastname: Guzman
authors.forename: Neil
authors.initials: N
authors.lastname: Woodford
authors.forename: David
authors.initials: D
authors.lastname: Livermore
authors.forename: John P
authors.initials: JP
authors.lastname: Quinn
mesh_terms: D000151:Acinetobacter Infections / Q000453:epidemiology* / Q000382:microbiology; D040981:Acinetobacter baumannii / Q000145:classification / Q000187:drug effects / Q000235:genetics*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000235:genetics* / Q000378:metabolism; D015780:Carbapenems / Q000494:pharmacology; D003105:Colombia / Q000453:epidemiology; D006761:Hospitals; D006801:Humans; D008826:Microbial Sensitivity Tests; D016133:Polymerase Chain Reaction; D011159:Population Surveillance; D018440:beta-Lactam Resistance; D001618:beta-Lactamases / Q000235:genetics* / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D015780:Carbapenems; C466679:beta-lactamase OXA-23; D001618:beta-Lactamases; C063912:carbapenemase