Novel synthon for incorporating 1,3-dimethyl imidazolium group into molecular architecture.
The synthesized 1,3-dimethylated imidazolium carbaldehydes serves as synthons for incorporating a permanently cationic imidazolium group into molecular framework. The utility of new synthon was demonstrated in a variety of reactions: Knoevenagel, Wittig, Schiff base formation, based mediated electrophilic substitution and oxidation, including synthesis of the natural product norzooanemonin.
Berezin
Mikhail
M
Department of Radiology, Washington University School of Medicine, 4525 Scott Ave, St. Louis, MO 63110, USA.
Achilefu
Samuel
S