Serum amyloid A and haptoglobin levels in bovine amyloidosis.
Serum amyloid A (SAA) and haptoglobin (Hp) levels were determined in 25 cows suffering from amyloidosis. SAA levels in cows with amyloidosis ranged between < 0.3 and 225.8 microg/ml, with a median level of 105.1 microg/ml, and Hp levels ranged between < 20 and 1860 microg/ml, with a median level of 950 microg/ml. These levels were significantly higher than the levels observed in healthy cows (SAA levels ranged from < 0.3 to 13.5 microg/ml, with median of 1.4 microg/ml, and Hp levels were undetectable in all cases), but were not significantly different from the levels observed in control cows with chronic inflammation. There was a significant correlation between SAA and Hp levels in cows with chronic inflammation , but not in cows with amyloidosis. It was concluded that the serum SAA levels in cows with amyloidosis might be changed by some factor other than inflammation.
Takahashi
Eiji
E
Department of Veterinary Clinical Science, United Graduate School of Veterinary Science, Gifu University, Japan.
Uzuka
Yuuji
Y
Tanabe
Sigeyuki
S
Satoh
Motoyoshi
M
Furuoka
Hidefumi
H
D000686:Amyloidosis / Q000097:blood / Q000662:veterinary*; D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay / Q000662:veterinary; D005260:Female; D006242:Haptoglobins / Q000032:analysis*; D000685:Serum Amyloid A Protein / Q000032:analysis*
D006242:Haptoglobins; D000685:Serum Amyloid A Protein