title: [123I]5-IA-85380 SPECT imaging of beta2-nicotinic acetylcholine receptor availability in the aging human brain.
abstract: Human postmortem studies have reported decreases with age in high-affinity nicotine binding in brain. We have been investigating in vivo the availability of the beta(2)-containing nicotinic acetylcholine receptor (beta(2)-nAChR) in healthy nonsmokers (18-85 years of age) using [(123)I]5-IA-85380 SPECT imaging. Age and regional beta(2)-nAChR availability (V(T)(,)) have been observed to be inversely correlated in all brain regions analyzed, with decline ranging from 21% (cerebellum) to 36% (thalamus), or by up to 5% per decade of life. Preliminary results have confirmed postmortem reports of age-related decline in high-affinity nicotine binding with age and may elucidate the role of beta(2)-nAChRs in the cognitive decline associated with aging.
authors.affiliation: Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA.
authors.forename: Effie M
authors.initials: EM
authors.lastname: Mitsis
authors.forename: Kelly P
authors.initials: KP
authors.lastname: Cosgrove
authors.forename: Julie K
authors.initials: JK
authors.lastname: Staley
authors.forename: Erin B
authors.initials: EB
authors.lastname: Frohlich
authors.forename: Frederic
authors.initials: F
authors.lastname: Bois
authors.forename: Gilles D
authors.initials: GD
authors.lastname: Tamagnan
authors.forename: Kristina M
authors.initials: KM
authors.lastname: Estok
authors.forename: John P
authors.initials: JP
authors.lastname: Seibyl
authors.forename: Christopher H
authors.initials: CH
authors.lastname: Van Dyck
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology; D001384:Azetidines; D001921:Brain / Q000000981:diagnostic imaging* / Q000254:growth & development; D001923:Brain Chemistry / Q000502:physiology*; D002531:Cerebellum / Q000254:growth & development / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011725:Pyridines; D019275:Radiopharmaceuticals; D011978:Receptors, Nicotinic / Q000187:drug effects*; D013788:Thalamus / Q000254:growth & development / Q000473:pathology; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D001384:Azetidines; D011725:Pyridines; D019275:Radiopharmaceuticals; D011978:Receptors, Nicotinic; C426745:5-iodo-3-(2-azetidinylmethoxy)pyridine