title: Experimental and theoretical investigations on the adsorption of 2'-deoxyguanosine oxidation products at oxidized boron-doped diamond electrodes.
abstract: Electrochemical oxidation of 2'-deoxyguanosine has been performed on boron-doped diamond (BDD) electrodes, resulting in a strong adsorption of the formed oxidized products onto the BDD surface. The adsorption behavior has been investigated by studying the electrochemical behavior of a redox probe ([IrCl6]3-) using cyclic voltammetry. The most probable situations are the formation of (A) an insulating adsorbed film resulting in a partially blocked electrode behavior, (B) a porous film, or (C) an overall conductive film. Different parameters such as the standard rate constant, the charge-transfer coefficient, the electrode/adsorbed products/solution interface resistance, and the formal potential of the redox couple were determined. Through comparison of theoretical current-potential curves obtained by analytical calculations with experimental cyclic voltammograms, we found that the oxidized products of 2'-deoxyguanosine form a continuous conductive film on BDD.
authors.affiliation: Groupe Chimie de la Reconnaissance et Etude des Assemblages Biologiques - SprAM (UMR 5819 CEA/CNRS/UJF), DRFMC/SPrAM/CREAB, CEA Grenoble, 17 rue des Martyrs, 38054 Grenoble Cedex 9, France.
authors.forename: Elodie
authors.initials: E
authors.lastname: Fortin
authors.forename: Eric
authors.initials: E
authors.lastname: Vieil
authors.forename: Pascal
authors.initials: P
authors.lastname: Mailley
authors.forename: Sabine
authors.initials: S
authors.lastname: Szunerits
authors.forename: Thierry
authors.initials: T
authors.lastname: Livache
mesh_terms: D000327:Adsorption; D001895:Boron; D003849:Deoxyguanosine; D018130:Diamond; D004563:Electrochemistry / Q000295:instrumentation / Q000379:methods*; D004566:Electrodes; D010084:Oxidation-Reduction
chemical_list: D018130:Diamond; D003849:Deoxyguanosine; D001895:Boron