Hypothermia following antipsychotic drug use.
OBJECTIVE
Hypothermia is an adverse drug reaction (ADR) of antipsychotic drug (APD) use. Risk factors for hypothermia in ADP users are unknown. We studied which risk factors for hypothermia can be identified based on case reports.


METHODS
Case reports of hypothermia in APD-users found in PUBMED or EMBASE were searched for risk factors. The WHO international database for Adverse Drug Reactions was searched for reports of hypothermia and APD use.


RESULTS
The literature search resulted in 32 articles containing 43 case reports. In the WHO database, 480 reports were registered of patients developing hypothermia during the use of APDs which almost equals the number of reports for hyperthermia associated with APD use (n = 524). Hypothermia risk seems to be increased in the first days following start or dose increase of APs. APs with strong 5-HT2 antagonism seem to be more involved in hypothermia; 55% of hypothermia reports are for atypical antipsychotics. Schizophrenia was the most prevalent diagnosis in the case reports.


CONCLUSIONS
Especially in admitted patients who are not able to control their own environment or physical status, frequent measurements of body temperature (with a thermometer that can measure low body temperatures) must be performed in order to detect developing hypothermia.
van Marum
Rob J
RJ
Geriatric Department, University Medical Centre, P.O. Box 85500, 3508 AB, Utrecht, The Netherlands. r.j.vanmarum@umcutrecht.nl
Wegewijs
Michelle A
MA
Loonen
Anton J M
AJ
Beers
Erna
E
D016907:Adverse Drug Reaction Reporting Systems; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D007035:Hypothermia / Q000139:chemically induced*; D012307:Risk Factors; D012559:Schizophrenia / Q000188:drug therapy; D014944:World Health Organization
D014150:Antipsychotic Agents