The effects of calcium channel blockers are not related to their chemical structure in the collar model of the rabbit.
Placing a silicone collar around the rabbit carotid artery induces intimal thickening, an early stage in atherosclerosis and restenosis. We investigatedwhethertreatment with oral pranidipine, a new potent, long-lasting dihydropyridine calcium channel blocker (CCB), inhibited collar-induced intimal thickening in addition to the changes in vascular reactivity usually observed in this model. Pranidipine treatment did not inhibit collar-induced intimal thickening. Placing the collar around the carotid artery resulted in the characteristic changes in vascular reactivity, such as increased sensitivity to 5-hydroxytryptamine. Treatment with Nomega-nitro-L-arginine (100 microM) and pranidipine, however, did not affect collar-induced changes in vascular reactivity. From results of this and previous studies, we conclude that pranidipine does not prevent collar-induced intimal thickening or collar-induced changes in vascular reactivity. Not all CCBs prevent collar-induced intimal thickening, suggesting that the effects of these agents are not related to their chemical structure and/or their calcium channel-blocking actions.
Yasa
M
M
Department of Pharmacology, Faculty of Pharmacy, Ege University, Izmir, Turkey.
Kerry
Z
Z
Reel
B
B
Yetik Anacak
G
G
Ertuna
E
E
Ozer
A
A
D000818:Animals; D050197:Atherosclerosis / Q000188:drug therapy*; D002121:Calcium Channel Blockers / Q000737:chemistry* / Q000494:pharmacology*; D002339:Carotid Arteries / Q000601:surgery; D004095:Dihydropyridines / Q000737:chemistry / Q000494:pharmacology*; D004195:Disease Models, Animal; D005260:Female; D008297:Male; D011817:Rabbits; D013329:Structure-Activity Relationship
D002121:Calcium Channel Blockers; D004095:Dihydropyridines; C048161:pranidipine