Effect of surgically removing subcutaneous fat by abdominoplasty on leptin concentrations and insulin sensitivity.
The aim of this study was to identify the effect of surgically removing subcutaneous fat by abdominoplasty on leptin concentrations and insulin sensitivity. An open clinical trial with a noninterventional parallel group was carried out in 12 obese women. After randomization, 6 volunteers were selected for abdominoplasty, and the other 6 women were considered as the noninterventional group. A metabolic profile, including leptin concentrations, and insulin tolerance test to assess insulin sensitivity were performed on all volunteers before intervention or nonintervention and 40-50 days afterward. A significant reduction in body mass index (30.7 +/- 0.9 versus 29.6 +/- 0.7 kg/m; P = 0.02) and in leptin concentrations (41.3 +/- 10.6 versus 32.0 +/- 10.2 ng/mL; P = 0.02) was observed after abdominoplasty. Insulin sensitivity did not change after intervention. In conclusion, surgically removing subcutaneous fat by abdominoplasty decreased leptin concentrations, with no change in insulin sensitivity.
Martínez-Abundis
Esperanza
E
Medical Research Unit in Clinical Epidemiology, Mexican Institute of Social Security, Guadalajara, Mexico. uiec@prodigy.net.mx
Molina-Villa
Carlos Alejandro
CA
González-Ortiz
Manuel
M
Robles-Cervantes
José Antonio
JA
Saucedo-Ortiz
José Antonio
JA
D000328:Adult; D015992:Body Mass Index; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D020738:Leptin / Q000097:blood*; D008875:Middle Aged; D009765:Obesity / Q000378:metabolism* / Q000601:surgery*; D018709:Statistics, Nonparametric; D050151:Subcutaneous Fat / Q000378:metabolism* / Q000601:surgery*
D020738:Leptin