Cell microvesicles during experimental endotoxemia.
The dynamics of microvesicle formation in arterial blood in generalized Schwartzman phenomenon was studied. Successive (with 24-h interval) intravenous injections of endotoxin to rabbits in a dose of 1 mg/kg and 3 mg/kg caused an increase in the content of microvesicles in the blood, some of them containing ecto-5'-nucleotidase. Biphasic changes in arterial blood clotting time and erythrocyte hemolysis were observed.
Zubairova
L D
LD
Department of Biochemistry, Kazan State Medical University. dilja2001@mail.ru
Zubairov
D M
DM
Andrushko
I A
IA
Svintenok
G Yu
GY
Mustafin
I G
IG
D015720:5'-Nucleotidase / Q000097:blood; D000818:Animals; D019446:Endotoxemia / Q000473:pathology*; D004731:Endotoxins; D008070:Lipopolysaccharides; D008297:Male; D021962:Membrane Microdomains / Q000187:drug effects / Q000378:metabolism*; D011817:Rabbits; D012790:Shwartzman Phenomenon
D004731:Endotoxins; D008070:Lipopolysaccharides; D015720:5'-Nucleotidase