title: Withanolides with phytotoxic activity from Jaborosa caulescens var. caulescens and J. caulescens var. bipinnatifida 1.
abstract: Seven new withanolides (1-7) were isolated from the aerial parts of Jaborosa caulescens var. caulescens and Jaborosa caulescens var. bipinnatifida. Three of the new compounds are related to jaborosalactones R, S, and T with a delta-lactone side chain and a hemiketal (or ketal) ring formed between a 21-hydroxyl and a 12-ketone (1-3). Compounds 4-7 are trechonolide-type withanolides with a gamma-lactone side chain and a hemiketal (or ketal) ring formed between a 22-hydroxyl and a 12-ketone. Compounds 4 and 5 also contain a hydroxyl group at C-21. Compounds 1, 2, and 7 showed selective phytotoxicity toward monocotyledonous and dicotyledonous species.
authors.affiliation: Departamento de Química OrgAnica and IMBIV, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, 5000 Córdoba, Argentina.
authors.forename: Viviana E
authors.initials: VE
authors.lastname: Nicotra
authors.forename: Roberto R
authors.initials: RR
authors.lastname: Gil
authors.forename: Juan C
authors.initials: JC
authors.lastname: Oberti
authors.forename: Gerardo
authors.initials: G
authors.lastname: Burton
mesh_terms: D001118:Argentina; D018554:Avena / Q000187:drug effects; D004875:Ergosterol / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018525:Germination / Q000187:drug effects; D006540:Herbicides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018545:Lactuca / Q000187:drug effects; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D036226:Seedlings / Q000187:drug effects; D019657:Solanaceae / Q000737:chemistry*
chemical_list: D006540:Herbicides; D004875:Ergosterol