Biological activity of hemoglobin-containing complex isolated from blood serum of mice with Ehrlich carcinoma.
Injection of hemoglobin-containing complex of serum proteins isolated from animals with Ehrlich carcinoma led to regression of intraperitoneally and intramuscularly transplanted Ehrlich carcinoma in male C57Bl/6 mice. The hemoglobin-containing complex of serum proteins disturbed cycle distribution of Ehrlich carcinoma cells and caused apoptosis of about 34.3% tumor cells. Addition of hemoglobin-containing serum protein complex into Ehrlich carcinoma incubation medium did not lead to the death of tumor cells and even slightly increased their proliferation.
Donenko
F V
FV
N. N. Blokhin Cancer Research Center, Russian Academy of Medical Sciences, Moscow. fedor@edito.umos.ru
Sitdikova
S M
SM
Amandzholov
B S
BS
Kiselevskii
M V
MV
D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D001798:Blood Proteins / Q000302:isolation & purification / Q000494:pharmacology*; D002286:Carcinoma, Ehrlich Tumor / Q000097:blood* / Q000473:pathology; D049109:Cell Proliferation / Q000187:drug effects*; D002478:Cells, Cultured; D006454:Hemoglobins / Q000302:isolation & purification / Q000494:pharmacology*; D007273:Injections, Intramuscular; D007274:Injections, Intraperitoneal; D008136:Longevity / Q000187:drug effects*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009368:Neoplasm Transplantation / Q000379:methods
D001798:Blood Proteins; D006454:Hemoglobins