Effect of transplantation of immunocompetent cell on orientation and exploratory behavior and cytokine gene expression in the brain of experimental animals.
Intravenous injection of adherent splenocyte fraction from donor (CBAxC57Bl/6)F(1) mice characterized by specific open-field behavior modified this behavior in syngeneic recipient mice. This was paralleled by appropriate changes in the levels of IL-1b and type 1 IL-1 receptor mRNA in the brain cells of recipient mice. Hence, we demonstrated the possibility of directed regulation of orientation and exploratory behavior in mice by transplantation of immunocompetent cells. Mononuclear phagocytes play an important role in this phenomenon.
Markova
E V
EV
Institute of Clinical Immunology, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk. evgeniya_markova@mail.ru
Abramov
V V
VV
Korotkova
N A
NA
Kozlov
V A
VA
D000818:Animals; D001921:Brain / Q000378:metabolism*; D017690:Cell Transplantation / Q000379:methods*; D003433:Crosses, Genetic; D016207:Cytokines / Q000235:genetics / Q000378:metabolism*; D005106:Exploratory Behavior; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009949:Orientation; D010586:Phagocytes / Q000637:transplantation*; D013154:Spleen / Q000166:cytology / Q000276:immunology; D014185:Transplantation, Isogeneic
D016207:Cytokines