title: Disordered lipid metabolism and the pathogenesis of insulin resistance.
abstract: Although abnormal glucose metabolism defines type 2 diabetes mellitus (T2DM) and accounts for many of its symptoms and complications, efforts to understand the pathogenesis of T2DM are increasingly focused on disordered lipid metabolism. Here we review recent human studies exploring the mechanistic links between disorders of fatty acid/lipid metabolism and insulin resistance. As "mouse models of insulin resistance" were comprehensively reviewed in Physiological Reviews by Nandi et al. in 2004, we will concentrate on human studies involving the use of isotopes and/or magnetic resonance spectroscopy, occasionally drawing on mouse models which provide additional mechanistic insight.
authors.affiliation: Department of Internal Medicine, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06536-8012, USA.
authors.forename: David B
authors.initials: DB
authors.lastname: Savage
authors.forename: Kitt Falk
authors.initials: KF
authors.lastname: Petersen
authors.forename: Gerald I
authors.initials: GI
authors.lastname: Shulman
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D005227:Fatty Acids / Q000494:pharmacology; D005947:Glucose / Q000378:metabolism; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D052439:Lipid Metabolism Disorders / Q000503:physiopathology*; D008099:Liver / Q000737:chemistry / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D009132:Muscles / Q000737:chemistry / Q000378:metabolism; D009765:Obesity / Q000378:metabolism
chemical_list: D005227:Fatty Acids; D005947:Glucose