Ferulic acid supplementation prevents trimethyltin-induced cognitive deficits in mice.
This study's objective was to clarify the ameliorative effects ferulic acid (4-hydroxy-3-methoxycinnamic acid) has against cognitive deficits and ChAT activation in trimethyltin (TMT) induced, memory injured mice following a 28-d ferulic acid treatment. After administering TMT for 3 d, each mouse performed Y-maze and passive avoidance tests to check immediate working memory performance and cognitive function. The results showed that ferulic acid administration attenuated TMT-induced memory injury and a decline in ChAT activity in the mice. This suggests that ferulic acid might be useful for preventing cognitive dysfunction as well as for boosting the activation of ChAT in dementia.
Kim
Mi Jeong
MJ
Graduate School of Life Sciences and Biotechnology, Korea University, Seoul, Korea.
Choi
Soo Jung
SJ
Lim
Seung-Taik
ST
Kim
Hye Kyung
HK
Heo
Ho Jin
HJ
Kim
Eun-Ki
EK
Jun
Woo Jin
WJ
Cho
Hong Yon
HY
Kim
Young Jun
YJ
Shin
Dong-Hoon
DH
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000201:enzymology; D002795:Choline O-Acetyltransferase / Q000378:metabolism; D003072:Cognition Disorders / Q000139:chemically induced* / Q000517:prevention & control* / Q000523:psychology; D003373:Coumaric Acids / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000494:pharmacology*; D008297:Male; D008568:Memory / Q000187:drug effects; D051379:Mice; D008813:Mice, Inbred ICR; D014298:Trimethyltin Compounds / Q000037:antagonists & inhibitors* / Q000633:toxicity*
D003373:Coumaric Acids; D016166:Free Radical Scavengers; D014298:Trimethyltin Compounds; C004999:ferulic acid; D002795:Choline O-Acetyltransferase