Anisaldehyde, a melanogenesis potentiator.
Anisaldehyde (4-methoxybenzaldehyde), previously reported as a tyrosinase inhibitor, did not inhibit melanogenesis in cultured B16-F10 melanoma cells but rather enhanced it. This adverse effect of anisaldehyde was accompanied by melanocytotoxicity in a dose-dependent manner up to 2 mM. The melanin content per cell at 1 mM was increased 5-fold compared to control and morphological observations showed the deposition of melanin pigments. Anisaldehyde was also examined against cultured human A375 melanoma cells.
Nitoda
Teruhiko
T
Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720, USA.
Fan
Maria D
MD
Kubo
Isao
I
D000818:Animals; D001547:Benzaldehydes / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D007211:Indoles / Q000494:pharmacology*; D007700:Kinetics; D008543:Melanins / Q000378:metabolism*; D008545:Melanoma / Q000473:pathology / Q000503:physiopathology*; D051379:Mice
D001547:Benzaldehydes; D007211:Indoles; D008543:Melanins; C009904:melanogen; C024896:4-anisaldehyde