Failure to over express MHC-CLASS-1 on muscle biopsy in a case of amyopathic juvenile dermatomyositis.
The concept of amyopathic dermatomyositis or dermatomyositis sine myositis, is contentious, particularly within paediatrics. We report an 8-year-old girl presenting with dermatological dermatomyositis without muscle weakness. Muscle biopsy changes are described, in particular, the absence of MHC class 1 over expression. This supports the concept of amyopathic dermatomyositis as a subgroup of juvenile dermatomyositis (JDM) and suggests that immunohistological analysis may be a valuable in excluding a myositic element in such cases.
McCann
L J
LJ
Rheumatology Unit, Royal Liverpool Children's Hospital, Liverpool, UK. lisa.mccann@rlc.nhs.uk
Li
C K C
CK
Varsani
H
H
Wedderburn
L R
LR
Pilkington
C A
CA
D001706:Biopsy; D002648:Child; D003882:Dermatomyositis / Q000175:diagnosis / Q000276:immunology* / Q000473:pathology; D005260:Female; D005805:Genes, MHC Class I; D006680:HLA Antigens / Q000378:metabolism*; D006801:Humans; D018908:Muscle Weakness; D018482:Muscle, Skeletal / Q000276:immunology / Q000473:pathology*
D006680:HLA Antigens