Synthesis of highly tritium labeled steroids for evaluation of aromatase and steroidsulfatase activities in endometrial tumors.
Data on activities of estrogen-synthesis enzymes (aromatase and steroidsulfatase) in endometrial tumors were obtained by sensitive and highly precise radioisotope methods. The results clear out some pathogenetic aspects in the development and progress of malignant tumors in the endometrium.
Bochkareva
N V
NV
Institute of Oncology, Tomsk Research Center, Siberian Division of Russian Academy of Medical Sciences. biochem@oncology.tomsk.ru
Kondakova
I V
IV
Kolomiets
L A
LA
Muntyan
A B
AB
Shevchenko
V P
VP
Nagaev
I Yu
IY
Shevchenko
K V
KV
Myasoedov
N F
NF
Dorofeeva
N N
NN
D001141:Aromatase / Q000378:metabolism*; D002454:Cell Differentiation; D016889:Endometrial Neoplasms / Q000201:enzymology* / Q000473:pathology*; D004970:Estrone / Q000031:analogs & derivatives / Q000378:metabolism; D005260:Female; D006801:Humans; D007553:Isotope Labeling / Q000379:methods; D008593:Menopause; D008875:Middle Aged; D009367:Neoplasm Staging; D017698:Postmenopause; D043266:Steryl-Sulfatase / Q000378:metabolism*; D014316:Tritium
D014316:Tritium; D004970:Estrone; D001141:Aromatase; D043266:Steryl-Sulfatase; C017296:estrone sulfate