Hydroperoxysterols from the tunicate Eudistoma sp.
Two 27C hydroperoxysterols, 7beta-hydroperoxycholesterol (1) and its stereoisomer 7alpha-hydroperoxycholesterol (2), were isolated from the lipophilic extracts of a Formosan tunicate belonging to the genus Eudistoma. The structures of sterols 1 and 2 were elucidated on the basis of extensive spectral data analyses. Cytotoxicity of sterols 1 and 2 against a limited panel of cancer cell lines is also described. Sterol 1 show weak inhibitory effects on human neutrophil elastase release.
Sung
Ping-Jyun
PJ
National Museum of Marine Biology and Aquarium, Pingtung, Taiwan, R.O.C. pjsung@nmmba.gov.tw
Lin
Mei-Ru
MR
Chen
Jih-Jung
JJ
Lin
Shen-Fan
SF
Wu
Yang-Chang
YC
Hwang
Tsong-Long
TL
Fang
Lee-Shing
LS
D000818:Animals; D045744:Cell Line, Tumor; D002851:Chromatography, High Pressure Liquid; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013261:Sterols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014561:Urochordata / Q000737:chemistry*
D013261:Sterols