title: Accrual of organ damage over time in Argentine patients with systemic lupus erythematosus: a multi-centre study.
abstract: The goals of this study were to ascertain damage in patients with systemic lupus erythematosus (SLE) from five rheumatologic centres in Argentina and to examine overall damage, damage by domain and damage by item within each domain. We performed a retrospective observational study including patients with SLE (ACR 1997 revised and modified criteria) from five rheumatology centres in Argentina. Organ damage was scored using the SLICC/ACR DI (SDI), ascertained at years 1, 2, 5 and 10. Three centres provided information up to the fifth year. Of the 197 patients, 88.3% were women and their mean age was 33.2 years. The mean disease duration and follow-up were 7.6 and 5.3 years, respectively. Damage accrued gradually over time with SDI ranging from 0.52 (+/-1.1) at year 1 up to 2.46 (+/-2.1) at year 10. The renal system was the most involved system, followed by the neuropsychiatric, the cardiovascular and the musculoskeletal systems. Proteinuria, cognitive impairment, pericarditis, avascular necrosis, cataract and alopecia were the predominant items in their respective systems. Systems such as peripheral vascular, pulmonary, gastrointestinal, diabetes, malignancy and premature gonadal failure were not frequent. Overall SDI had a gradual increase over time. Damage in each domain of SDI, except for diabetes, had a similar behaviour. Behaviour of items in each domain varied.
authors.affiliation: Rheumatology Section, Department of Internal Medicine, Hospital J.M. Cullen, Av Freyre 2150, Santa Fe, Argentina.
authors.forename: Gustavo
authors.initials: G
authors.lastname: Cassano
authors.affiliation: Rheumatology Section, Department of Internal Medicine, Hospital J.M. Cullen, Av Freyre 2150, Santa Fe, Argentina.
authors.forename: Susana
authors.initials: S
authors.lastname: Roverano
authors.affiliation: Rheumatology Section, Department of Internal Medicine, Hospital J.M. Cullen, Av Freyre 2150, Santa Fe, Argentina. pairasergio@fibertel.com.ar.
authors.forename: Sergio
authors.initials: S
authors.lastname: Paira
authors.affiliation: Rheumatology Section, Department of Internal Medicine, Hospital Padilla, Tucumán, Argentina.
authors.forename: Verónica
authors.initials: V
authors.lastname: Bellomio
authors.affiliation: Rheumatology Section, Department of Internal Medicine, Hospital Padilla, Tucumán, Argentina.
authors.forename: Eleonora
authors.initials: E
authors.lastname: Lucero
authors.affiliation: Rheumatology Section, Department of Internal Medicine, Hospital Padilla, Tucumán, Argentina.
authors.forename: Alberto
authors.initials: A
authors.lastname: Berman
authors.affiliation: Rheumatology Section, Department of Internal Medicine, Hospital Padilla, Tucumán, Argentina.
authors.forename: Alberto
authors.initials: A
authors.lastname: Spindler
authors.affiliation: Rheumatology Section, Hospital Municipal Nuestra Señora de Luján, Lujan, Buenos Aires, Argentina.
authors.forename: Rosana
authors.initials: R
authors.lastname: Trobo
authors.affiliation: Rheumatology Section, Hospital Nuestra Señora de Luján, Luján, Buenos Aires, Argentina.
authors.forename: Luis Fernando
authors.initials: LF
authors.lastname: Somma
authors.affiliation: Hospital San Martín, Paraná, Entre Ríos, Argentina.
authors.forename: César
authors.initials: C
authors.lastname: Graf
authors.affiliation: Rheumatology Section, Department of Internal Medicine, Hospital Tornú, Buenos Aires, Argentina.
authors.forename: Alejandra
authors.initials: A
authors.lastname: Barrionuevo
authors.affiliation: Rheumatology Section, Department of Internal Medicine, Hospital Tornú, Buenos Aires, Argentina.
authors.forename: Silvia
authors.initials: S
authors.lastname: Papasidero
authors.affiliation: Rheumatology Section, Department of Internal Medicine, Hospital Tornú, Buenos Aires, Argentina.
authors.forename: Oscar
authors.initials: O
authors.lastname: Rillo
mesh_terms: D000328:Adult; D001118:Argentina / Q000453:epidemiology; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000453:epidemiology* / Q000503:physiopathology; D008297:Male; D012189:Retrospective Studies; D012720:Severity of Illness Index; D015996:Survival Rate; D013997:Time Factors