title: Inhibitory effects of caffeine on hippocampal neurogenesis and function.
abstract: Caffeine is one of the most extensively consumed psychostimulants in the world. However, compared to short-term effects of caffeine, the long-term effects of caffeine consumption on learning and memory are poorly characterized. The present study found that long-term consumption of low dose caffeine (0.3 g/L) slowed hippocampus-dependent learning and impaired long-term memory. Caffeine consumption for 4 weeks also significantly reduced hippocampal neurogenesis compared to controls. From these results, we concluded that long-term consumption of caffeine could inhibit hippocampus-dependent learning and memory partially through inhibition of hippocampal neurogenesis.
authors.affiliation: Department of Anatomy, School of Medicine, Pusan National University, 1-10 Ami-Dong, Seo-Gu, Pusan 602-739, Republic of Korea.
authors.forename: Myoung-Eun
authors.initials: ME
authors.lastname: Han
authors.forename: Kyu-Hyun
authors.initials: KH
authors.lastname: Park
authors.forename: Sun-Yong
authors.initials: SY
authors.lastname: Baek
authors.forename: Bong-Seon
authors.initials: BS
authors.lastname: Kim
authors.forename: Jae-Bong
authors.initials: JB
authors.lastname: Kim
authors.forename: Hak-Jin
authors.initials: HJ
authors.lastname: Kim
authors.forename: Sae-Ock
authors.initials: SO
authors.lastname: Oh
mesh_terms: D000818:Animals; D002110:Caffeine / Q000008:administration & dosage*; D049109:Cell Proliferation / Q000187:drug effects; D006624:Hippocampus / Q000166:cytology* / Q000187:drug effects / Q000502:physiology*; D018782:Maze Learning / Q000187:drug effects*; D009433:Neural Inhibition / Q000187:drug effects* / Q000502:physiology; D009474:Neurons / Q000166:cytology* / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D002110:Caffeine