title: High prevalence of abnormal Pap smears among young women co-infected with HIV in rural South Africa - implications for cervical cancer screening policies in high HIV prevalence populations.
abstract: OBJECTIVE
  To establish the relationship between HIV infection and cervical dysplasia in young women in rural South Africa.
  
  
  METHODS
  This cross-sectional study was conducted at a primary health care clinic in Vulindlela, KwaZulu- Natal. Standardised questionnaires were used to collect sociodemographic and clinical presentation data from women attending family planning and other reproductive health services. Pap smears were done using standard methods. Pap smear data were linked to HIV serostatus.
  
  
  RESULTS
  Four hundred and sixty-six women were included in the study. The median age was 24.3 years (range 15 - 55 years), and 80% were younger than 30 years. The HIV prevalence rate was 24.5% (95% confidence interval: 20.7 - 28.7%) and the prevalence of abnormal Pap smears was 16.9 - 6.4% ASCUS (atypical squamous cells of undetermined significance), 9.2% LGSIL (low-grade squamous intraepithelial lesions), and 1.3% HGSIL (high-grade squamous intraepithe lial lesions). The association between HIV seropositivity and abnormal Pap results was statistically significant (p < 0.05).
  
  
  CONCLUSIONS
  There is a need for more data on cervical changes in HIV co-infected women and for review of guidelines on selective Pap smear screening in high HIV prevalence settings such as sub-Saharan Africa and where access to antiretroviral treatment remains limited.
authors.affiliation: Faculty of Medicine, Addis Ababa University, Ethiopia, and Centre for the AIDS Programme of Research in South Africa (CAPRISA), University of KwaZulu-Natal, Durban, South Africa.
authors.forename: Asheber
authors.initials: A
authors.lastname: Gaym
authors.forename: May
authors.initials: M
authors.lastname: Mashego
authors.forename: Ayesha B M
authors.initials: AB
authors.lastname: Kharsany
authors.forename: Jenny
authors.initials: J
authors.lastname: Walldorf
authors.forename: Janet
authors.initials: J
authors.lastname: Frohlich
authors.forename: Quarraisha Abdool
authors.initials: QA
authors.lastname: Karim
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000453:epidemiology / Q000517:prevention & control; D006801:Humans; D008403:Mass Screening / Q000379:methods*; D008875:Middle Aged; D065006:Papanicolaou Test; D015995:Prevalence; D012189:Retrospective Studies; D012424:Rural Population / Q000706:statistics & numerical data*; D013019:South Africa / Q000453:epidemiology; D002583:Uterine Cervical Neoplasms / Q000150:complications / Q000175:diagnosis*; D014626:Vaginal Smears