Role of activity-dependent mechanisms in the control of dopaminergic neuron survival.
Dopaminergic neurons that constitute the nigrostriatal pathway are characterized by singular electrical properties that allow them to discharge in vivo spontaneously in a spectrum of patterns ranging from pacemaker to random and bursting modes. These electrophysiological features allow dopaminergic neurons to optimize the release of dopamine in their terminal fields. However, there is emerging evidence indicating that electrical activity might also participate in the control of dopaminergic neuron survival, not only during development, but also in the adult brain, thus raising the possibility that alterations in ionic currents could contribute actively to the demise of these neurons in Parkinson disease. This review focuses on the mechanisms by which activity-dependent mechanisms might modulate dopaminergic cell survival.
Michel
Patrick P
PP
INSERM, UMR679, Paris, France. ppmichel@ccr.jussieu.fr
Alvarez-Fischer
Daniel
D
Guerreiro
Serge
S
Hild
Audrey
A
Hartmann
Andreas
A
Hirsch
Etienne C
EC
D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D002470:Cell Survival / Q000502:physiology; D004298:Dopamine / Q000378:metabolism*; D006801:Humans; D007473:Ion Channels / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism*; D010300:Parkinson Disease / Q000378:metabolism / Q000503:physiopathology; D017981:Receptors, Neurotransmitter / Q000378:metabolism; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D013378:Substantia Nigra / Q000378:metabolism*
D007473:Ion Channels; D017981:Receptors, Neurotransmitter; D000254:Sodium-Potassium-Exchanging ATPase; D004298:Dopamine