title: The IL-10 (-627 A/C) promoter polymorphism may be associated with coronary aneurysms and low serum albumin in Korean children with Kawasaki disease.
abstract: Kawasaki disease (KD) is an acute febrile vasculitic syndrome of unknown etiology that preferentially affects the coronary artery. Interleukin-10 (IL-10) is a key proinflammatory cytokine, and a polymorphism near the major transcriptional start site of the IL-10 gene was shown to influence IL-10 production in vitro. This study investigated the association of the IL-10 promoter polymorphism with KD and its clinical parameters in Korean children. A total of 194 children with congenital heart disease (CHD) and 95 children with KD were included in this study. IL-10 (-627 A/C) polymorphism genotypes were determined using the single-base extension method. There was no difference in the allele frequencies of IL-10 (-627 A/C) polymorphism between CHD children and KD children. KD children with one or two copies of the IL-10 (-627C) allele showed significantly lower albumin levels (p = 0.020) and higher frequencies of early coronary artery aneurysm [62.22% versus 37.78%, adjusted odds ratio (aOR) = 3.50, 95% confidence interval (CI): 1.50-8.16] compared with KD children with the common IL-10 (-627A) allele. These findings suggest that the IL-10 (-627 A/C) promoter polymorphism might be a genetic marker for the risk of early coronary artery complication in KD.
authors.affiliation: Department of Pediatrics, College of Medicine, Ulsan University, Asian Medical Center, Seoul 138-736, Korea.
authors.forename: Hyun-Seung
authors.initials: HS
authors.lastname: Jin
authors.forename: Hyo Bin
authors.initials: HB
authors.lastname: Kim
authors.forename: Bong Seong
authors.initials: BS
authors.lastname: Kim
authors.forename: Jong-Keuk
authors.initials: JK
authors.lastname: Lee
authors.forename: Eul-Ju
authors.initials: EJ
authors.lastname: Seo
authors.forename: Han-Wook
authors.initials: HW
authors.lastname: Yoo
authors.forename: In Sook
authors.initials: IS
authors.lastname: Park
authors.forename: Young Mi
authors.initials: YM
authors.lastname: Hong
authors.forename: Soo-Jong
authors.initials: SJ
authors.lastname: Hong
mesh_terms: D044466:Asian People; D002675:Child, Preschool; D003323:Coronary Aneurysm / Q000097:blood / Q000235:genetics / Q000276:immunology; D005260:Female; D005787:Gene Frequency; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D007723:Korea; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000097:blood / Q000235:genetics / Q000276:immunology / Q000473:pathology; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D012709:Serum Albumin
chemical_list: D012709:Serum Albumin; D016753:Interleukin-10