title: [Importance of urgent cerebrospinal fluid examination for early diagnosis of central nervous system infections].
abstract: To a certain extent, the cerebrospinal fluid (CSF) composition reflects the current status of the central nervous system (CNS). Therefore, studying changes in even the most essential CSF parameters provides enormous scope for obtaining valuable information about processes in the CNS in relation to its disorders. The article aims at presenting our current conception of urgent CSF examination with special emphasis on early diagnosis of central nervous infections. In particular, the focus is on evaluating energy conditions in the CSF compartment and permeability of the blood-brain and blood-CSF barriers, CSF cytology, detecting CNS tissue destruction and bleeding into CNS pathways and monitoring the levels of systemic inflammatory activity.
authors.affiliation: Department of Clinical Biochemistry and Haematology, Regional Hospital Kadan, Czech Republic. kelbich@nemkadan.cz
authors.forename: Petr
authors.initials: P
authors.lastname: Kelbich
authors.forename: Martina
authors.initials: M
authors.lastname: Koudelková
authors.forename: Hana
authors.initials: H
authors.lastname: Machová
authors.forename: Miloslav
authors.initials: M
authors.lastname: Tomaskovic
authors.forename: Petr
authors.initials: P
authors.lastname: Vachata
authors.forename: Patricie
authors.initials: P
authors.lastname: Kotalíková
authors.forename: Vlasta
authors.initials: V
authors.lastname: Chmelíková
authors.forename: Eva
authors.initials: E
authors.lastname: Hanuljaková
mesh_terms: D015415:Biomarkers / Q000134:cerebrospinal fluid; D001812:Blood-Brain Barrier; D002494:Central Nervous System Infections / Q000134:cerebrospinal fluid / Q000175:diagnosis*; D002555:Cerebrospinal Fluid / Q000737:chemistry* / Q000166:cytology; D042241:Early Diagnosis; D004630:Emergencies; D004734:Energy Metabolism; D006801:Humans
chemical_list: D015415:Biomarkers