Metabolism of parthenin by Beauveria bassiana ATCC 7159.
Two new metabolites were isolated from the biotransformation reaction of parthenin by Beauveria bassiana ATCC 7159 along with the known naturally occurring sesquiterpene lactones hymenolin and dihydrocoronopilin. The new metabolites: are 3beta,4beta,6beta-trihydroxy-10alphaH,11alpha-methyl-ambrosa-1 -en-12-oic acid-gamma-lactone and 3alpha,6beta-dihydroxy-4beta-hydroperoxy-10alphaH, 11alpha-methyl-ambrosa-1-en-12-oic acid-gamma-lactone. The structure elucidation of these compounds was achieved by different spectroscopic methods.
Abdel Halim
O B
OB
Department of Pharmacognosy, Faculty of Pharmacy, University of Mansoura, Mansoura, Egypt.
Maatooq
G T
GT
Marzouk
A M
AM
D052982:Beauveria / Q000378:metabolism*; D005285:Fermentation; D017665:Hydroxyl Radical / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D012717:Sesquiterpenes / Q000032:analysis* / Q000378:metabolism; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
C519216:3alpha,6beta-dihydroxy-4beta-hydroperoxy-10alphaH,11alpha-methyl-ambrosa-1-en-12-oic acid-gamma-lactone; C519215:3beta,4beta,6beta-trihydroxy-10alphaH,11alpha-methyl-ambrosa-1 -en-12-oic acid-gamma-lactone; D012717:Sesquiterpenes; D017665:Hydroxyl Radical; C022097:parthenin