Antitumor and antibacterial activity of ethylacetate extract of Ludwigia hyssopifolia linn and its active principle piperine.
An alkaloid constituent 1-[5-(1,3-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl]piperidine, trivial name piperine was isolated from Ludwigia hyssopifolia Linn. (Family-Onagraceae). The ethylacetate extract of the plant and the isolated compound piperine were studied for antitumor and in vitro antibacterial activity. Ethylacetate extract showed 73.05 and 84.14% inhibition of Agrobacterium tumefaciens-induced crown gall tumor formation in potato disc. Piperine exhibited antitumor activity with IC50 value of 13.50 microg/disc. Both ethylacetate extract and piperine showed mild to moderate antibacterial activity against selected Gram-positive and Gram-negative bacteria.
Das
Banibrata
B
Department of Pharmaceutical Technology, Faculty of Pharmacy, Dhaka University, Dhaka-1000, Bangladesh.
Kundu
Juthika
J
Bachar
Sitesh Chandra
SC
Uddin
Mohammad Aftab
MA
Kundu
Joydeb Kumar
JK
D000085:Acetates / Q000737:chemistry*; D016960:Agrobacterium tumefaciens / Q000187:drug effects / Q000472:pathogenicity; D000470:Alkaloids / Q000302:isolation & purification / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology*; D052117:Benzodioxoles / Q000302:isolation & purification / Q000494:pharmacology*; D006090:Gram-Negative Bacteria / Q000187:drug effects / Q000254:growth & development; D006094:Gram-Positive Bacteria / Q000187:drug effects / Q000254:growth & development; D008826:Microbial Sensitivity Tests; D029594:Onagraceae; D010880:Piperidines / Q000302:isolation & purification / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D010941:Plant Tumors / Q000382:microbiology; D053284:Polyunsaturated Alkamides / Q000302:isolation & purification / Q000494:pharmacology*; D012997:Solvents / Q000737:chemistry*
D000085:Acetates; D000470:Alkaloids; D000900:Anti-Bacterial Agents; D000972:Antineoplastic Agents, Phytogenic; D052117:Benzodioxoles; D010880:Piperidines; D010936:Plant Extracts; D053284:Polyunsaturated Alkamides; D012997:Solvents; C007650:ethyl acetate; C008922:piperine