title: Effects of creatine supplementation on glucose tolerance and insulin sensitivity in sedentary healthy males undergoing aerobic training.
abstract: Recent findings have indicated that creatine supplementation may affect glucose metabolism. This study aimed to examine the effects of creatine supplementation, combined with aerobic training, on glucose tolerance in sedentary healthy male. Subjects (n = 22) were randomly divided in two groups and were allocated to receive treatment with either creatine (CT) ( approximately 10 g . day over three months) or placebo (PT) (dextrose). Administration of treatments was double blind. Both groups underwent moderate aerobic training. An oral glucose tolerance test (OGTT) was performed and both fasting plasma insulin and the homeostasis model assessment (HOMA) index were assessed at the start, and after four, eight and twelve weeks. CT demonstrated significant decrease in OGTT area under the curve compared to PT (P = 0.034). There were no differences between groups or over time in fasting insulin or HOMA. The results suggest that creatine supplementation, combined with aerobic training, can improve glucose tolerance but does not affect insulin sensitivity, and may warrant further investigation with diabetic subjects.
authors.affiliation: Laboratory of Applied Nutrition and Metabolism, Physical Education and Sport School, University of São Paulo, São Paulo, Brazil.
authors.forename: B
authors.initials: B
authors.lastname: Gualano
authors.forename: R B
authors.initials: RB
authors.lastname: Novaes
authors.forename: G G
authors.initials: GG
authors.lastname: Artioli
authors.forename: T O
authors.initials: TO
authors.lastname: Freire
authors.forename: D F
authors.initials: DF
authors.lastname: Coelho
authors.forename: F B
authors.initials: FB
authors.lastname: Scagliusi
authors.forename: P S
authors.initials: PS
authors.lastname: Rogeri
authors.forename: H
authors.initials: H
authors.lastname: Roschel
authors.forename: C
authors.initials: C
authors.lastname: Ugrinowitsch
authors.forename: A H
authors.initials: AH
authors.lastname: Lancha
mesh_terms: D000328:Adult; D003401:Creatine / Q000494:pharmacology*; D015444:Exercise / Q000502:physiology*; D005947:Glucose / Q000378:metabolism*; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood / Q000502:physiology*; D008297:Male
chemical_list: D007328:Insulin; D005947:Glucose; D003401:Creatine