title: Secondary metabolites from the roots of Engelhardia roxburghiana and their antitubercular activities.
abstract: Engelharquinone (1), engelharquinone epoxide (2), engelharolide (3), and engelhardic acid (4), were isolated as naturally occurring products from a plant source, Engelhardia roxburghiana together with 20 previously known compounds, four of which were hitherto not known as plant constituents. Their structures were identified by means of spectroscopic analysis. A biological evaluation showed that three of the previously isolated antitubercular constituents [(-)-4-hydroxy-1-tetralone, 3-methoxyjuglone and engelhardione] and engelharquinone (1) exhibited moderate antitubercular activity against Mycobacterium tuberculosis 90-221387.
authors.affiliation: Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan, ROC.
authors.forename: Che-Chen
authors.initials: CC
authors.lastname: Wu
authors.forename: Chien-Fang
authors.initials: CF
authors.lastname: Peng
authors.forename: Ian-Lih
authors.initials: IL
authors.lastname: Tsai
authors.forename: Mohamed H
authors.initials: MH
authors.lastname: Abd El-Razek
authors.forename: He-Shun
authors.initials: HS
authors.lastname: Huang
authors.forename: Ih-Sheng
authors.initials: IS
authors.lastname: Chen
mesh_terms: D000995:Antitubercular Agents / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology*; D029525:Juglandaceae / Q000737:chemistry / Q000378:metabolism*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D018517:Plant Roots / Q000737:chemistry / Q000378:metabolism*
chemical_list: D000995:Antitubercular Agents