Basic science for the clinician 43: the mitogen-activated protein kinase family in inflammatory signaling.
Growth factors, cytokines, chemokines, apoptotic stimuli, TLR ligands, stress-a lot can happen to a cell in day-to-day living, but these are extracellular phenomena, and all influence the inner workings of the cell. Once the ligand binds to the receptor, or the stress, occurs, changes occur within the cell that eventuate in intranuclear transcription of new genes, subsequent changes in cellular structure and function, and often in the release of chemicals that transmit signals to self (autocrine) and other cells (paracrine and juxtacrine). Often, these changes occur due to the activation of cascades of kinases, a perireceptor choreography that is only now being elucidated. The human "kinome" (the various families of kinases) is very complex; we will limit ourselves in this discussion to the mitogen-activated protein kinases.
Sigal
Leonard H
LH
Pharmaceutical Research Institute, Bristol-Myers Squibb, Princeton, New Jersey 08543-4000, USA. leonard.sigal@bms.com
D006801:Humans; D007249:Inflammation / Q000201:enzymology* / Q000503:physiopathology; D020928:Mitogen-Activated Protein Kinases / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology
D020928:Mitogen-Activated Protein Kinases