title: Malignant pleural mesothelioma: two cases in first degree relatives.
abstract: We report two cases of malignant pleural mesothelioma in first degree relatives arising within weeks of each other. The patients had a shared exposure to asbestos and age difference of over 20 years at time of presentation. In both cases, the anatomical pattern was similar and unusual for mesothelioma and initial histology was reported for both as non-small cell lung cancer. Both patients were treated with platinum-based combination chemotherapy.
authors.affiliation: Department of Medical Oncology, Royal Marsden Hospital, Sutton, SURREY SM2 5PT, United Kingdom.
authors.forename: Anna
authors.initials: A
authors.lastname: Wilkins
authors.forename: Sanjay
authors.initials: S
authors.lastname: Popat
authors.forename: Sarah
authors.initials: S
authors.lastname: Hughes
authors.forename: Mary
authors.initials: M
authors.lastname: O'Brien
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001194:Asbestos / Q000633:toxicity; D005190:Family; D006801:Humans; D008297:Male; D008654:Mesothelioma / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000235:genetics; D008875:Middle Aged; D010984:Platinum / Q000627:therapeutic use; D010997:Pleural Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000235:genetics; D014057:Tomography, X-Ray Computed
chemical_list: D000970:Antineoplastic Agents; D001194:Asbestos; D010984:Platinum