The ins and outs of secretion from pancreatic beta-cells: control of single-vesicle exo- and endocytosis.
Exocytosis of insulin-containing secretory vesicles in pancreatic beta-cells is crucial to maintenance of plasma glucose levels. They fuse with the plasma membrane in a regulated manner to release their contents and are subsequently recaptured either intact or through conventional clathrin-mediated endocytosis. Here, we discuss these mechanisms in beta-cells at the single-vesicle level.
MacDonald
Patrick E
PE
Department of Pharmacology, University of Alberta, Edmonton, Alberta, Canada. pmacdonald@bcell.org
Rorsman
Patrik
P
D000818:Animals; D002462:Cell Membrane / Q000502:physiology; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology; D004594:Electrophysiology; D004705:Endocytosis / Q000502:physiology*; D005089:Exocytosis / Q000502:physiology*; D006801:Humans; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D050417:Insulin-Secreting Cells / Q000378:metabolism* / Q000502:physiology; D022142:Secretory Vesicles / Q000502:physiology*
D007328:Insulin