[Mucociliary transport in patients with chronic obstructive lung disease from the cotton-growing areas of Uzbekistan].
Based on the data on 98 patients with chronic obstructive lung disease (COLD) of varying severity from the cotton-growing areas of Uzbekistan, including 66 patients with pesticide accumulation and 32 without the latter, the authors studied the mycociliary transport (MCT) by the time of MCT, adhesiveness, and surface tension of sputum, as well as its content of bound and free water. The studies point to the development of significant mucociliary insufficiency that deteriorates the signs of bronchial obstruction in patients with COLD with pesticide accumulation. With the longer release of an inhaled indicator (MCT time > 48 hours), peak forced expiratory flow rates (PFEFR) were found to considerably decrease in this category of patients than in patients without impaired MCT (PEFR 1.8 +/- 0.6 l/sec versus 5.9 +/- 0.3 l/sec. The increases in sputum adhesiveness and surface tension may be used as an additional criterion of MCT impairments.
Arifkhanova
S I
SI
Ubaĭdullaeva
K M
KM
Liverko
I V
IV
D000328:Adult; D018556:Crops, Agricultural; D003627:Data Interpretation, Statistical; D004781:Environmental Exposure / Q000009:adverse effects; D005260:Female; D003368:Gossypium; D006801:Humans; D008297:Male; D008875:Middle Aged; D009079:Mucociliary Clearance; D010366:Peak Expiratory Flow Rate; D010575:Pesticides / Q000009:adverse effects / Q000378:metabolism; D029424:Pulmonary Disease, Chronic Obstructive / Q000139:chemically induced / Q000378:metabolism / Q000503:physiopathology*; D013183:Sputum / Q000378:metabolism; D014610:Uzbekistan
D010575:Pesticides