Integrating noninvasive molecular imaging into molecular medicine: an evolving paradigm.
Molecular imaging is a rapidly emerging field, providing noninvasive visual quantitative representations of fundamental biological processes in intact living subjects. Fundamental biomedical research stands to benefit considerably from advances in molecular imaging, with improved molecular target selection, probe development and imaging instrumentation. The noninvasiveness of molecular imaging technologies will also provide benefit through improved patient care. Molecular imaging endpoints can be quantified, and therefore are particularly useful for translational research. Integration of the two disciplines of molecular imaging and molecular medicine, combined with systems-biology approaches to understanding disease complexity, promises to provide predictive, preventative and personalized medicine that will transform healthcare.
Massoud
Tarik F
TF
Department of Radiology, University of Cambridge School of Clinical Medicine, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ, UK. tfm23@radiol.cam.ac.uk
Gambhir
Sanjiv S
SS
D000818:Animals; D035843:Biomedical Research / Q000379:methods; D003952:Diagnostic Imaging / Q000379:methods / Q000639:trends*; D015195:Drug Design; D006801:Humans; D051379:Mice; D023421:Models, Animal; D008954:Models, Biological; D025202:Molecular Diagnostic Techniques; D009683:Nuclear Medicine / Q000639:trends*; D049490:Systems Biology / Q000379:methods / Q000639:trends