title: Effect of aloe vera leaf gel extract on membrane bound phosphatases and lysosomal hydrolases in rats with streptozotocin diabetes.
abstract: Diabetes mellitus is known to promote deterioration of membrane function and impair intra cellular metabolism in the organism. The aim of the present study was to examine the effect of the ethanolic extract from Aloe vera leaf gel on membrane bound phosphatases and lysosomal hydrolases in the liver and kidney of streptozotocin (STZ)-induced diabetic rats. The rats treated with STZ showed significant alterations in the activities of membrane bound phosphatases and lysosomal hydrolases in the liver and kidney. Oral administration of Aloe vera gel extract at a dose of 300 mg/kg body weight/day to STZ-induced diabetic rats for a period of 21 days significantly restored the alterations in enzymes activity to near normalcy. These results were compared with glibenclamide, a reference drug. Thus, the present study confirms that Aloe vera gel extract possesses a significant beneficial effect on membrane bound phosphatases and lysosomal hydrolases.
authors.affiliation: Department of Advanced Biochemistry, University of Madras, Guindy Campus, Chennai, India. rajasekarphd@gmail.com
authors.forename: S
authors.initials: S
authors.lastname: Rajasekaran
authors.forename: N
authors.initials: N
authors.lastname: Sriram
authors.forename: P
authors.initials: P
authors.lastname: Arulselvan
authors.forename: S
authors.initials: S
authors.lastname: Subramanian
mesh_terms: D000251:Adenosine Triphosphatases / Q000378:metabolism; D000504:Aloe / Q000737:chemistry*; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002462:Cell Membrane / Q000187:drug effects / Q000201:enzymology*; D003921:Diabetes Mellitus, Experimental / Q000201:enzymology*; D005905:Glyburide / Q000494:pharmacology; D006867:Hydrolases / Q000378:metabolism*; D007004:Hypoglycemic Agents / Q000494:pharmacology; D008247:Lysosomes / Q000201:enzymology*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism*; D010936:Plant Extracts / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D006867:Hydrolases; D010744:Phosphoric Monoester Hydrolases; D000251:Adenosine Triphosphatases; D005905:Glyburide