Polypharmacy: when is it rational?
In this article, the authors discuss when it makes sense to consider using more than one medication to treat a single condition. They give a brief history of the use of polypharmacy in psychiatry and discuss how new discoveries in psychotropic drug development are making polypharmacy an increasingly important topic today. The authors then present a list of 10 criteria to guide the rational use of psychotropic polypharmacy and explain each in detail with examples drawn from clinical practice.
Preskorn
Sheldon H
SH
University of Kansas School of Medicine-Wichita, Clinical Research Institute, Wichita, KS 67211, USA.
Lacey
Ronald L
RL
D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D006801:Humans; D016014:Linear Models; D001523:Mental Disorders / Q000097:blood / Q000188:drug therapy*; D017410:Practice Guidelines as Topic; D011619:Psychotropic Drugs / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics
D011619:Psychotropic Drugs