Preparation of substituted anilines from nitro compounds by using supported gold catalysts.
A protocol for the chemoselective hydrogenation of nitro compounds to the corresponding anilines by means of supported gold catalysts is described. Nitro groups on different compounds--containing double bonds, carbonyl, nitrile or amide groups--have been successfully hydrogenated on supported gold nanoparticles (Au/TiO2 and Au/Fe2O3), using a batch reactor under H2 pressure. Unlike other noble metals, gold shows high chemoselectivity towards reduction of the nitro group, at near-complete conversion of the substrate. The total time to carry out this protocol strongly depends on the reaction step, which is a function of the activity of the catalyst and the nature of the substrate.
Corma
Avelino
A
Instituto de Tecnología Química, UPV-CSIC, Av. los Naranjos, s/n, Valencia 46022, Spain. acorma@itq.upv.es
Serna
Pedro
P
D000814:Aniline Compounds / Q000138:chemical synthesis*; D002384:Catalysis; D006046:Gold / Q000737:chemistry*; D006865:Hydrogenation; D009578:Nitrobenzenes / Q000737:chemistry*
D000814:Aniline Compounds; D009578:Nitrobenzenes; D006046:Gold