Glycogen synthase kinase-3beta -- actively inhibiting hypertrophy.
A number of signaling pathways are involved in the regulation of cardiac hypertrophy and remodeling. One that serves as an integrator of upstream inputs, and as a transducer to downstream effectors, is the protein kinase, glycogen synthase kinase-3beta. In this work we review the role of this putative "nodal point" in the response of the heart to growth stimuli, both physiologic and pathologic.
Kerkelä
Risto
R
Center for Translational Medicine, Jefferson Medical College, Philadelphia, PA 19107, USA.
Woulfe
Kathleen
K
Force
Thomas
T
D000818:Animals; D004789:Enzyme Activation / Q000187:drug effects; D038362:Glycogen Synthase Kinase 3 / Q000037:antagonists & inhibitors / Q000378:metabolism*; D000071679:Glycogen Synthase Kinase 3 beta; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000378:metabolism* / Q000503:physiopathology / Q000517:prevention & control*; D032383:Myocytes, Cardiac / Q000378:metabolism / Q000473:pathology; D047428:Protein Kinase Inhibitors / Q000494:pharmacology; D015398:Signal Transduction / Q000187:drug effects; D020257:Ventricular Remodeling / Q000187:drug effects; D051153:Wnt Proteins / Q000378:metabolism
D047428:Protein Kinase Inhibitors; D051153:Wnt Proteins; C000605506:GSK3B protein, human; D000071679:Glycogen Synthase Kinase 3 beta; D038362:Glycogen Synthase Kinase 3