Effect of Kluyveromyces marxianus YIT 8292 crude cell wall fraction on serum lipids in normocholesterolemic and mildly hypercholesterolemic subjects.
The hypocholesterolemic effects of Kluyveromyces marxianus YIT 8292 crude cell wall (KM-CW) were examined. In pilot studies, KM-CW tablets were administered to mildly hypercholesterolemic subjects at doses of 8.0, 4.0, 2.0, or 1.0 g/d for 4 weeks. Total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) decreased at doses above 2.0 and 4.0 g/d, respectively. Further, we examined the effect of intake of yogurt containing 3.0 or 4.0 g of KM-CW/d for 8 weeks in normal and hypercholesterolemic subjects in a double-blind placebo-controlled study. The intake of either of the KM-CW-containing yogurts was associated with significantly improved TC and LDL-C in hypercholesterolemic subjects, but had no effect on these levels in normal subjects. TC was significantly lower at week 8 in the hypercholesterolemic subjects who ingested yogurt containing 3.0 or 4.0 g of KM-CW than in those who consumed placebo yogurt. Intake of KM-CW might contribute to the prevention of hypercholesterolemia.
Yoshida
Yasuto
Y
Yakult Central Institute for Microbiological Research, Tokyo, Japan. yasuto-yoshida@yakult.co.jp
Naito
Eiichiro
E
Ohishi
Kenji
K
Okumura
Takekazu
T
Ito
Masahiko
M
Sato
Tadashi
T
Sawada
Haruji
H
D000328:Adult; D000368:Aged; D002473:Cell Wall / Q000737:chemistry*; D002784:Cholesterol / Q000097:blood*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood*; D007716:Kluyveromyces / Q000737:chemistry*; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D013607:Tablets; D014280:Triglycerides / Q000097:blood; D015014:Yogurt
D008055:Lipids; D013607:Tablets; D014280:Triglycerides; D002784:Cholesterol