Studies of interactions between platinum(II) complexes and some biologically relevant molecules.
The reactions of Pt(II) complexes, cis-[Pt(NH3)2Cl2], [Pt(terpy)Cl]+, [Pt(terpy)(S-cys)]2+, and [Pt(terpy)(N7-guo)]2+, where terpy=2,2':6',2''-terpyridine, S-cys=L-cysteine, and N7-guo=guanosine, with some biologically relevant ligands such as guanosine-5'-monophosphate (5'-GMP), L-cysteine, glutathione (GSH) and some strong sulfur-containing nucleophiles such as diethyldithiocarbamate (dedtc), thiosulfate (sts), and thiourea (tu), were studied in aqueous 0.1 M Hepes at pH of 7.4 using UV-vis, stopped-flow spectrophotometry, and 1H NMR spectroscopy.
Petrović
Dejan
D
University of Kragujevac, Faculty of Medicine, S. Markovića 69, 34000 Kragujevac, Serbia.
Stojimirović
Biljana
B
Petrović
Biljana
B
Bugarcić
Zorica M
ZM
Bugarcić
Zivadin D
ZD
D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D017671:Platinum Compounds / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet
D017671:Platinum Compounds