Polyamines and mRNA stability in regulation of intestinal mucosal growth.
The mammalian intestinal epithelium is a rapidly self-renewing tissue in the body, and its homeostasis is preserved through strict regulation of epithelial cell proliferation, growth arrest, and apoptosis. Polyamines are necessary for normal intestinal mucosal growth and decreasing cellular polyamines inhibits cell proliferation and disrupts epithelial integrity. An increasing body of evidence indicates that polyamines regulate intestinal epithelial cell renewal by virtue of their ability to modulate expression of various genes and that growth inhibition following polyamine depletion results primarily from the activation of growth-inhibiting genes rather than a simple decrease in expression of growth-promoting genes. In this review article, we will focus on changes in expression of growth-inhibiting genes following polyamine depletion and further analyze in some detail the mechanisms through which mRNA stability is regulated by RNA-binding proteins.
Wang
J-Y
JY
Cell Biology Group, Departments of Surgery and Pathology, University of Maryland School of Medicine and Baltimore Veterans Affairs Medical Center, Baltimore, MD 21201, USA. jwang@smail.umaryland.edu
D020413:3' Untranslated Regions / Q000378:metabolism; D000818:Animals; D000954:Antigens, Surface / Q000502:physiology; D015317:Biogenic Polyamines / Q000502:physiology*; D003593:Cytoplasm / Q000378:metabolism; D051959:ELAV Proteins; D000067780:ELAV-Like Protein 1; D000518:Eflornithine / Q000494:pharmacology; D006801:Humans; D007413:Intestinal Mucosa / Q000254:growth & development*; D008954:Models, Biological; D009955:Ornithine Decarboxylase / Q000378:metabolism; D065108:Ornithine Decarboxylase Inhibitors; D016755:Proto-Oncogene Proteins c-jun / Q000502:physiology; D011700:Putrescine / Q000494:pharmacology; D012333:RNA, Messenger / Q000378:metabolism*; D016601:RNA-Binding Proteins / Q000502:physiology; D051785:Smad Proteins / Q000502:physiology; D016212:Transforming Growth Factor beta / Q000235:genetics; D016159:Tumor Suppressor Protein p53 / Q000502:physiology
D020413:3' Untranslated Regions; D000954:Antigens, Surface; D015317:Biogenic Polyamines; D051959:ELAV Proteins; D000067780:ELAV-Like Protein 1; C098770:ELAVL1 protein, human; D065108:Ornithine Decarboxylase Inhibitors; D016755:Proto-Oncogene Proteins c-jun; D012333:RNA, Messenger; D016601:RNA-Binding Proteins; D051785:Smad Proteins; D016212:Transforming Growth Factor beta; D016159:Tumor Suppressor Protein p53; D009955:Ornithine Decarboxylase; D011700:Putrescine; D000518:Eflornithine