title: Serotonergic response to stress: a protective factor against abnormal dopaminergic reactivity in schizophrenia?
abstract: In a double-blind-crossover-study, 10 patients with schizophrenia, 10 of their unaffected siblings and 9 healthy controls randomly received metabolic stressor and placebo. A significant HVA plasma elevation in response to stress was found in siblings whose response was intermediate to that of patients and controls. Only siblings additionally displayed an exaggerated 5HIAA response.
authors.affiliation: Université de Lyon, Lyon, F-69003, France. jerome.brunelin@ch-le-vinatier.fr
authors.forename: Jerome
authors.initials: J
authors.lastname: Brunelin
authors.forename: Thierry
authors.initials: T
authors.lastname: D'amato
authors.forename: Jim
authors.initials: J
authors.lastname: van Os
authors.forename: Jean
authors.initials: J
authors.lastname: Dalery
authors.forename: Marie-Françoise
authors.initials: MF
authors.lastname: Suaud-Chagny
authors.forename: Mohamed
authors.initials: M
authors.lastname: Saoud
mesh_terms: D000328:Adult; D000963:Antimetabolites; D001143:Arousal / Q000235:genetics; D018592:Cross-Over Studies; D003847:Deoxyglucose; D004298:Dopamine / Q000502:physiology*; D004311:Double-Blind Method; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006719:Homovanillic Acid / Q000097:blood*; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000097:blood*; D008297:Male; D012016:Reference Values; D012307:Risk Factors; D012559:Schizophrenia / Q000097:blood* / Q000235:genetics; D012569:Schizotypal Personality Disorder / Q000097:blood / Q000235:genetics; D035781:Siblings; D012931:Social Environment; D013312:Stress, Physiological / Q000097:blood / Q000150:complications*
chemical_list: D000963:Antimetabolites; D006897:Hydroxyindoleacetic Acid; D003847:Deoxyglucose; D004298:Dopamine; D006719:Homovanillic Acid