title: Three antinematodal diterpenes from Euphorbia kansui.
abstract: Three compounds, 20-O-acetyl-[3-O-(2'E,4'Z)-decadienoyl]-ingenol (1), 20-O-acetyl-[5-O-(2'E,4'Z)-decadienoyl]-ingenol (2) and 3-O-(2'E,4'Z)-decadienoylingenol (3), were isolated from Euphorbia kansui under the bioassay-guided method. Each compound showed the same antinematodal activity against the nematode, Bursaphelenchus xylophilus, at a minimum effective dose (MED) of 5 microg/cotton ball.
authors.affiliation: The Graduate School of Natural Science and Technology, Department of Biofunctional Chemistry, Laboratory of Applied Natural Products Chemistry, Okayama University, Okayama, Japan.
authors.forename: Jian-Xiao
authors.initials: JX
authors.lastname: Shi
authors.forename: Zhi-Xuan
authors.initials: ZX
authors.lastname: Li
authors.forename: Teruhiko
authors.initials: T
authors.lastname: Nitoda
authors.forename: Minoru
authors.initials: M
authors.lastname: Izumi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kanzaki
authors.forename: Naomichi
authors.initials: N
authors.lastname: Baba
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Kawazu
authors.forename: Shuhei
authors.initials: S
authors.lastname: Nakajima
mesh_terms: D000969:Antinematodal Agents / Q000302:isolation & purification* / Q000494:pharmacology*; D002855:Chromatography, Thin Layer; D004224:Diterpenes / Q000138:chemical synthesis / Q000302:isolation & purification* / Q000494:pharmacology*; D028481:Euphorbia / Q000737:chemistry*; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D018517:Plant Roots / Q000737:chemistry; D021241:Spectrometry, Mass, Electrospray Ionization; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
chemical_list: C521267:20-O-acetyl-(3-O-decadienoyl)ingenol; C521268:20-O-acetyl-(5-O-decadienoyl)ingenol; C521269:3-O-decadienoylingenol; D000969:Antinematodal Agents; D004224:Diterpenes; D007202:Indicators and Reagents