title: Elevated plasma levels of high mobility group box protein 1 in patients with HIV-1 infection.
abstract: High mobility group box protein 1 (HMGB1) is a potent proinflammatory mediator. It has a dichotomic effect on HIV-1 replication in vitro but its role in vivo is unknown. Here we report the novel finding that plasma HMGB1 levels are elevated in HIV-1-infected patients, with the highest concentrations in patients with clinical complications. HMGB1 is likely to contribute to immunoactivation in HIV-1 infection in vivo.
authors.affiliation: Divisions of Clinical Virology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
authors.forename: Piotr
authors.initials: P
authors.lastname: Nowak
authors.forename: Babilonia
authors.initials: B
authors.lastname: Barqasho
authors.forename: Anders
authors.initials: A
authors.lastname: Sönnerborg
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000097:blood; D018791:CD4 Lymphocyte Count; D005260:Female; D015658:HIV Infections / Q000097:blood* / Q000276:immunology / Q000821:virology; D015497:HIV-1; D024243:HMGB1 Protein / Q000097:blood*; D006801:Humans; D008297:Male; D019562:Viral Load
chemical_list: D024243:HMGB1 Protein