title: Breast implant capsules are partially composed of bone marrow-derived cells.
abstract: Capsular contracture is the most common complication following breast augmentation or reconstruction with implants. We recently demonstrated that bone marrow-derived cells provide fibroblasts to murine skin during wound healing. To determine if bone marrow-derived cells were the cellular source of periprosthetic capsules, we created chimeric C57BL mice containing bone marrow cells from isogeneic enhanced green fluorescent protein (EGFP) mice and implanted with a textured silicone shell implant. We found that none of the mice developed infection or capsular contracture, but day 30 capsules were composed of 26.4 +/- 6.1% EGFP cells, and day 60 capsules had 21.8 +/- 10.3% EGFP cells. Immunohistochemistry revealed a small population of EGFP cells in the capsules that were myofibroblasts. Thus, breast implant capsules are partially composed of bone marrow-derived cells and, given the potential of these cells to become myofibroblasts, may explain the cellular source of capsular contracture when it develops.
authors.affiliation: University of Washington Medical Center, Seattle, WA 98195, USA.
authors.forename: Casey
authors.initials: C
authors.lastname: Isom
authors.forename: Vishal
authors.initials: V
authors.lastname: Kapoor
authors.forename: Lynne
authors.initials: L
authors.lastname: Wilson
authors.forename: Carrie
authors.initials: C
authors.lastname: Fathke
authors.forename: Leigh
authors.initials: L
authors.lastname: Barnes
authors.forename: Stephen R
authors.initials: SR
authors.lastname: Sullivan
authors.forename: F Frank
authors.initials: FF
authors.lastname: Isik
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells; D018427:Breast Implants / Q000009:adverse effects*; D002678:Chimera; D003286:Contracture; D005347:Fibroblasts / Q000166:cytology*; D005549:Foreign-Body Reaction / Q000473:pathology*; D049452:Green Fluorescent Proteins; D007150:Immunohistochemistry; D051379:Mice; D008810:Mice, Inbred C57BL; D012828:Silicones / Q000009:adverse effects
chemical_list: D012828:Silicones; D049452:Green Fluorescent Proteins