Monarch-1/PYPAF7 and other CATERPILLER (CLR, NOD, NLR) proteins with negative regulatory functions.
CATERPILLER is a mammalian gene family with signature NBD and LRR domains. Several members of this family are positive regulators of inflammatory responses. Others, however, exert negative effects on proinflammatory responses. These data are particularly convincing when shRNA/siRNA are used. This review focuses on the Monarch-1/PYPAF7 gene with brief discussions of CLR16.2/NOD3, PYPAF2/PAN1/NALP2, and PYPAF3.
Lich
John D
JD
Lineberger Comprehensive Cancer Center, Department of Microbiology-Immunology, CB7295, University of North Carolina, Chapel Hill, NC 27599-7295, USA.
Ting
Jenny Pan-Yun
JP
D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000502:physiology*; D047908:Intracellular Signaling Peptides and Proteins / Q000502:physiology*; D053473:Nod2 Signaling Adaptor Protein / Q000502:physiology; D013601:T-Lymphocytes / Q000378:metabolism / Q000502:physiology*
D036341:Intercellular Signaling Peptides and Proteins; D047908:Intracellular Signaling Peptides and Proteins; C503285:NLRC3 protein, human; C476731:NLRP12 protein, human; D053473:Nod2 Signaling Adaptor Protein