Study on glycosylated prodrugs of toxoflavins for antibody-directed enzyme tumor therapy.
Eight novel toxoflavin glycosides, which are potential prodrugs in antibody directed enzyme prodrug therapy (ADEPT), were synthesized. The structures of all toxoflavin glycosides were characterized by (13)C NMR spectroscopy, elemental analysis, and MS. Their enzymatic hydrolysis activities were tested against beta-glucosidase (EC.3.2.1.21).
Wang
Shusheng
S
School of Life Sciences, Northeast Normal University, Changchun 130024, PR China.
Liu
Dan
D
Zhang
Xu
X
Li
Shengyu
S
Sun
Yongxu
Y
Li
Jia
J
Zhou
Yifa
Y
Zhang
Liping
L
D000906:Antibodies / Q000276:immunology*; D006027:Glycosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D007167:Immunotherapy / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy; D009369:Neoplasms / Q000628:therapy; D011355:Prodrugs / Q000737:chemistry* / Q000627:therapeutic use; D011744:Pyrimidinones / Q000737:chemistry* / Q000627:therapeutic use; D014227:Triazines / Q000737:chemistry* / Q000627:therapeutic use; D001616:beta-Galactosidase / Q000737:chemistry / Q000378:metabolism
D000906:Antibodies; D006027:Glycosides; D011355:Prodrugs; D011744:Pyrimidinones; D014227:Triazines; C009570:toxoflavin; D001616:beta-Galactosidase