title: Terpenoid-related metabolites from a formosan soft coral Nephthea chabrolii.
abstract: Two new sesquiterpenoidal natural products chabrolidiones A and B (1 and 2), two C(18) terpenoid-related carboxylic acids, ketochabrolic acid (3) and isoketochabrolic acid (4), and one naphthoquinone derivative chabrolonaphthoquinone C (5), along with two known compounds (+)-aristolone (6) and teuhetenone A (7) were isolated from a Formosan soft coral Nephthea chabrolii. The structures of the new metabolites were determined on the basis of extensive spectroscopic analysis and by comparison of NMR data with those of related metabolites. Metabolite 1 has been synthesized previously, but was isolated for the first time from natural sources. Cytotoxic activity of metabolites 1-3 and 5-7 against a limited panel of cancer cell lines is also described.
authors.affiliation: Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaoshiung, Taiwan, R.O.C.
authors.forename: Jui-Hsin
authors.initials: JH
authors.lastname: Su
authors.forename: Chang-Feng
authors.initials: CF
authors.lastname: Dai
authors.forename: Hsin-Hui
authors.initials: HH
authors.lastname: Huang
authors.forename: Yang-Chang
authors.initials: YC
authors.lastname: Wu
authors.forename: Ping-Jyun
authors.initials: PJ
authors.lastname: Sung
authors.forename: Chi-Hsin
authors.initials: CH
authors.lastname: Hsu
authors.forename: Jyh-Horng
authors.initials: JH
authors.lastname: Sheu
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D015394:Molecular Structure; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013729:Terpenes / Q000302:isolation & purification* / Q000378:metabolism
chemical_list: D013729:Terpenes