[123I]5-IA-85380 SPECT imaging of beta2-nicotinic acetylcholine receptor availability in the aging human brain.
Human postmortem studies have reported decreases with age in high-affinity nicotine binding in brain. We have been investigating in vivo the availability of the beta(2)-containing nicotinic acetylcholine receptor (beta(2)-nAChR) in healthy nonsmokers (18-85 years of age) using [(123)I]5-IA-85380 SPECT imaging. Age and regional beta(2)-nAChR availability (V(T)(,)) have been observed to be inversely correlated in all brain regions analyzed, with decline ranging from 21% (cerebellum) to 36% (thalamus), or by up to 5% per decade of life. Preliminary results have confirmed postmortem reports of age-related decline in high-affinity nicotine binding with age and may elucidate the role of beta(2)-nAChRs in the cognitive decline associated with aging.
Mitsis
Effie M
EM
Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA.
Cosgrove
Kelly P
KP
Staley
Julie K
JK
Frohlich
Erin B
EB
Bois
Frederic
F
Tamagnan
Gilles D
GD
Estok
Kristina M
KM
Seibyl
John P
JP
Van Dyck
Christopher H
CH
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology; D001384:Azetidines; D001921:Brain / Q000000981:diagnostic imaging* / Q000254:growth & development; D001923:Brain Chemistry / Q000502:physiology*; D002531:Cerebellum / Q000254:growth & development / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011725:Pyridines; D019275:Radiopharmaceuticals; D011978:Receptors, Nicotinic / Q000187:drug effects*; D013788:Thalamus / Q000254:growth & development / Q000473:pathology; D015899:Tomography, Emission-Computed, Single-Photon
D001384:Azetidines; D011725:Pyridines; D019275:Radiopharmaceuticals; D011978:Receptors, Nicotinic; C426745:5-iodo-3-(2-azetidinylmethoxy)pyridine