Synthesis of lipid derivatives of pyrrole polyamide and their biological activity.
Novel fatty acyl and phospholipid derivatives of pyrrole polyamide were synthesized. Their cytotoxicity against a cancer cell line of MT-4 cells and those infected by human immunodeficiency virus (HIV) was examined. Although no anti-HIV activity was found, their cytotoxicitty against the cancer cells was significantly enhanced by introducing a lipophilic group into the pyrrole polyamide.
Yamamoto
Masahiko
M
Department of Biofunctional Chemistry, Graduate School of Natural Science and Technology, Okayama University, Okayama, Japan.
Zhu
Changjin
C
Yi
Lui
L
Rong
Zheng
Z
Miura
Yoshie
Y
Izumi
Minoru
M
Nakajima
Shuhei
S
Tanamoto
Ken-Ichi
K
Shimizu
Sakayu
S
Baba
Naomichi
N
D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D005227:Fatty Acids / Q000737:chemistry; D006801:Humans; D007202:Indicators and Reagents; D008055:Lipids / Q000138:chemical synthesis* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D009757:Nylons / Q000138:chemical synthesis* / Q000494:pharmacology*; D010743:Phospholipids / Q000737:chemistry; D011758:Pyrroles / Q000138:chemical synthesis* / Q000494:pharmacology*
D019380:Anti-HIV Agents; D000970:Antineoplastic Agents; D005227:Fatty Acids; D007202:Indicators and Reagents; D008055:Lipids; D009757:Nylons; D010743:Phospholipids; D011758:Pyrroles