The matrix comes to lung transplantation.
Lung transplantation is complicated by fibroproliferation, which is likely mediated in part by matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs. This commentary briefly discusses what is known about these mediators in fibrotic pulmonary diseases and how an important new study by Yoshida and colleagues sheds light on the diverse functions of these proteins in alloimmune inflammation.
Babu
Ashok N
AN
Department of Surgery, University of Colorado Health Sciences Center, Denver, CO 80262, USA.
Nicolls
Mark R
MR
D015551:Autoimmunity / Q000502:physiology*; D006084:Graft Rejection / Q000209:etiology / Q000276:immunology; D006801:Humans; D016040:Lung Transplantation / Q000276:immunology*; D061965:Matrix Metalloproteinase Inhibitors; D020782:Matrix Metalloproteinases / Q000502:physiology*; D011014:Pneumonia / Q000276:immunology / Q000503:physiopathology; D011658:Pulmonary Fibrosis / Q000276:immunology / Q000503:physiopathology*; D019714:Tissue Inhibitor of Metalloproteinases / Q000502:physiology
D061965:Matrix Metalloproteinase Inhibitors; D019714:Tissue Inhibitor of Metalloproteinases; D020782:Matrix Metalloproteinases