Seizure activity affects neuroglial Kv1 channel immunoreactivities in the gerbil hippocampus.
In order to confirm the species-specific distribution of voltage-gated K(+) (Kv) channels and the definitive relationship between their immunoreactivities and seizure activity, we investigated Kv1 channel immunoreactivities in the hippocampus of seizure resistant (SR) and seizure sensitive (SS) gerbils. There was distinct difference of the Kv1 channel subtypes immunoreactivity in the hippocampi in both SR and SS gerbils. Kv1.1, Kv1.2, Kv1.3, Kv1.4, and Kv1.6 immunoreactivities in the SS gerbil hippocampus were lower than that in the SR gerbil hippocampus. However, Kv1 immunoreactivities were obviously presented in astrocyte within the stratum radiatum of the CA1 region of pre-seizure SS gerbil hippocampus. Following seizure-onset, Kv1 immunoreactivities (except Kv1.5) were markedly elevated, whereas their immunoreactivites in astrocytes were down-regulated. Therefore, the present study demonstrates that seizure activity may distinctly affect neuroglial Kv1 immunoreactivities in the gerbil hippocampus.
Kim
Duk-Soo
DS
Department of Anatomy, College of Medicine, Hallym University, Chunchon 200-702, Kangwon-Do, South Korea.
Kim
Ji-Eun
JE
Kwak
Sung-Eun
SE
Won
Moo Ho
MH
Kang
Tae-Cheon
TC
D000818:Animals; D002452:Cell Count / Q000379:methods; D005849:Gerbillinae; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D006624:Hippocampus / Q000378:metabolism / Q000473:pathology*; D007150:Immunohistochemistry; D009457:Neuroglia / Q000378:metabolism*; D010320:Parvalbumins / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D012640:Seizures / Q000473:pathology*; D051637:Shaker Superfamily of Potassium Channels / Q000145:classification / Q000378:metabolism*
D005904:Glial Fibrillary Acidic Protein; D010320:Parvalbumins; D051637:Shaker Superfamily of Potassium Channels