Upper and lower limb motor impairments in alcoholism, HIV infection, and their comorbidity.
BACKGROUND
Both HIV infection and alcoholism can impair motor abilities involving manual dexterity and postural stability. Given the high prevalence of HIV and alcoholism comorbidity, we examined whether each disease selectively disrupts different components of upper and lower limb motor control and whether these impairments are compounded by disease comorbidity.


METHODS
Simple and complex upper (speed and finger dexterity) and lower (static posture) limb functions were tested in 31 men with HIV infection, 27 with alcoholism, 43 comorbid for HIV infection and alcoholism, and 22 normal healthy controls to assess whether comorbid patients would demonstrate greater motor impairment relative to those with a single diagnosis.


RESULTS
Individuals with HIV infection and those with alcoholism had impaired upper and lower limb motor function. Disease comorbidity compounded deficits in speeded finger movement. Neither Beck Depression Inventory scores, self-reported peripheral neuropathy, nor HIV medication accounted for group differences. Lower limb motor composite scores with eyes open were correlated with upper limb motor scores in the alcoholism group.


CONCLUSIONS
Overall, the observed impairment patterns indicate the presence of upper and lower limb motor impairment in both HIV infection and alcoholism and the relevance of alcoholism in exacerbating impairment in speeded fine finger movement, when it occurs in HIV infection.
Fama
Rosemary
R
Neuroscience Program, SRI International, Menlo Park, California, USA.
Eisen
Jeffrey C
JC
Rosenbloom
Margaret J
MJ
Sassoon
Stephanie A
SA
Kemper
Carol A
CA
Deresinski
Stanley
S
Pfefferbaum
Adolf
A
Sullivan
Edith V
EV
D000328:Adult; D000428:Alcohol Drinking / Q000503:physiopathology / Q000523:psychology; D000437:Alcoholism / Q000150:complications / Q000503:physiopathology*; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects; D016022:Case-Control Studies; D003863:Depression / Q000503:physiopathology; D015658:HIV Infections / Q000150:complications / Q000503:physiopathology*; D006801:Humans; D035002:Lower Extremity / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009043:Motor Activity / Q000502:physiology*; D010523:Peripheral Nervous System Diseases / Q000503:physiopathology; D034941:Upper Extremity / Q000503:physiopathology*