title: Right ventricle injury during acute pulmonary embolism leads to its remodeling.
abstract: Right ventricular (RV) overload and hypoxia in acute pulmonary embolism (APE) may lead to RV myocardium injury reflected by elevated cardiac troponin levels. We studied 26 patients aged 57.2+/-17.8 years with first episode of APE. On admission troponin T (TnT) was measured. Transthoracic echocardiography was performed after 6 months of anticoagulation. Myocardial injury (TnT > or =0.03 ng/ml) was observed in 8 (30.8%) patients at the diagnosis. At follow up RV diastolic area tended to be larger in group with myocardial injury (25.0 (20.8-38.6) vs 18.4 (17.7-23.3) cm(2), p=0.06). Tricuspid annulus systolic velocity at tissue Doppler was lower in group with myocardial injury (0.12 (0.11-0.13) vs 0.15 (0.13-0.21) m/s, p=0.04), while no such a relationship was found for mitral annulus systolic velocity. TnT concentration correlated with RV diastolic area (r=0.61) and tricuspid annulus systolic velocity (r=-0.58) although not significantly (p=0.08 and p=0.09. respectively). Our data suggest that RV injury in acute phase of PE may lead to its remodeling.
authors.forename: Anna
authors.initials: A
authors.lastname: Kaczyńska
authors.forename: Marcin
authors.initials: M
authors.lastname: Szulc
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Styczyński
authors.forename: Maciej
authors.initials: M
authors.lastname: Kostrubiec
authors.forename: Ryszard
authors.initials: R
authors.lastname: Pacho
authors.forename: Piotr
authors.initials: P
authors.lastname: Pruszczyk
mesh_terms: D000208:Acute Disease; D005260:Female; D006352:Heart Ventricles / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology*; D011446:Prospective Studies; D011655:Pulmonary Embolism / Q000150:complications* / Q000503:physiopathology; D012307:Risk Factors; D013318:Stroke Volume; D020107:Troponin T / Q000097:blood; D014463:Ultrasonography; D018497:Ventricular Dysfunction, Right / Q000000981:diagnostic imaging / Q000209:etiology*
chemical_list: D020107:Troponin T