Nilvadipine prevents the impairment of spatial memory induced by cerebral ischemia combined with beta-amyloid in rats.
In the present study, we examined the effects of nilvadipine and amlodipine, both dihydropyridine-derivative calcium antagonists, on the impairment of spatial memory induced by a combination of ischemia and beta-amyloid (Abeta). Nilvadipine (3.2 mg/kg, i.p.) significantly prevented the impairment of spatial memory and neuronal apoptosis in this model. By contrast, amlodipine had no effect on this impairment of spatial memory. These findings suggest that nilvadipine may prevent impairment of spatial memory by inhibiting neuronal apoptosis; this drug might therefore be useful for the prevention of the progression to dementia in Alzheimer's disease (AD).
Iwasaki
Katsunori
K
Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan. iwasakik@fukuoka-u.ac.jp
Egashira
Nobuaki
N
Takagaki
Yuki
Y
Yoshimitsu
Yoshitaka
Y
Hatip-Al-Khatib
Izzettin
I
Mishima
Kenichi
K
Fujiwara
Michihiro
M
D016229:Amyloid beta-Peptides / Q000633:toxicity*; D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D002545:Brain Ischemia / Q000503:physiopathology*; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008569:Memory Disorders / Q000188:drug therapy*; D009474:Neurons / Q000187:drug effects; D009543:Nifedipine / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013028:Space Perception / Q000187:drug effects*
D016229:Amyloid beta-Peptides; D002121:Calcium Channel Blockers; C035100:nilvadipine; D009543:Nifedipine