[Bone marrow stem cells in the treatment of ischemic heart disease].
Cardiac cells possess limited ability to regeneration. Therefore acute myocardial infarction results in replacement of "perished" cardiomyocytes by scar tissue. The consequence of this is lowering of myocardial contractile function and development of heart failure. Novel approach to improvement of blood supply, contractility and possibly heart failure prevention--transplantation of stem cells--has attracted increasing attention during recent years. The use of autologous bone marrow stem cells is one of most perspective directions of cellular therapy. Until present time mechanism of action of stem cells, necessary amount of cellular material, most adequate method of stem cells introduction, methods of diagnosis of clinical efficacy of cellular therapy have not been fully elucidated.
Rakhmat-Zade
T M
TM
Skridlevskaia
E A
EA
Achkurin
R S
RS
D006333:Heart Failure / Q000209:etiology / Q000517:prevention & control; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006801:Humans; D009200:Myocardial Contraction; D017202:Myocardial Ischemia / Q000150:complications / Q000503:physiopathology / Q000601:surgery*; D016896:Treatment Outcome