Philadelphia variant, t(5;9;22)(q13;q34;q11), in a case with chronic myeloid leukemia.
In this paper we report on a case of chronic myeloid leukemia (CML) with a Philadelphia variant involving chromosome 5 as a second change of the standard Philadelphia chromosome (Ph). Molecular analysis found a fusion gene BCR-ABL with participation of exons b3 and a2, respectively (b3a2). The molecular variant of the fusion gene BCR/ ABL or the rare involvement of chromosome 5 could possibly explain the mild course of the disease.
Balatzenko
G
G
National Centre of Haematology and Transfusiology, Sofia, Bulgaria.
Grudeva-Popova
J
J
Krustev
T
T
Marichkov
D
D
Stefanova
M
M