Synthesis of 4-O-glycosylated 1-deoxynojirimycin derivatives as disaccharide mimics-based inhibitors of human beta-glucocerebrosidase.
Examples of a new type of inhibitor of human beta-glucocerebrosidase based on imino-disaccharides as glycosylceramide mimetics have been synthesized by way of the glycosylation of 1-deoxynojirimycin derivatives with 2,3,4,6-tetra-O-acetyl-alpha-D-glucopyranosyl bromide.
Boucheron
Charlotte
C
Institut de Chimie Organique et Analytique, CNRS-Université d'Orléans, rue de Chartres, BP 6759, 45067 Orléans, France.
Toumieux
Sylvestre
S
Compain
Philippe
P
Martin
Olivier R
OR
Ikeda
Kyoko
K
Asano
Naoki
N
D017485:1-Deoxynojirimycin / Q000737:chemistry* / Q000494:pharmacology; D002236:Carbohydrate Conformation; D004187:Disaccharides / Q000138:chemical synthesis* / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis*; D005962:Glucosylceramidase / Q000037:antagonists & inhibitors*; D006031:Glycosylation; D006801:Humans; D007202:Indicators and Reagents; D007700:Kinetics; D008958:Models, Molecular; D008968:Molecular Conformation
D004187:Disaccharides; D004791:Enzyme Inhibitors; D007202:Indicators and Reagents; D017485:1-Deoxynojirimycin; D005962:Glucosylceramidase