Metabolism and pharmacokinetics in children and the elderly.
In drug development, clinical trials are commonly carried out in either healthy volunteers or carefully selected patients. However, it has been recognised for a long time that both extremes of age, children and elderly, display a number of important metabolic and pharmacokinetic differences as compared with adults. This also has important consequences as to the toxic reactions and risk assessment of chemicals. What is known, what is not known and what should we do to improve the situation?
Pelkonen
Olavi
O
University of Oulu, Department of Pharmacology and Toxicology, Oulu, Finland. olavi.pelkonen@oulu.fi
D000367:Age Factors; D000368:Aged; D001711:Biotransformation; D002648:Child; D002986:Clinical Trials as Topic / Q000379:methods; D064420:Drug-Related Side Effects and Adverse Reactions / Q000139:chemically induced; D006801:Humans; D004364:Pharmaceutical Preparations / Q000008:administration & dosage / Q000378:metabolism*; D010599:Pharmacokinetics; D012307:Risk Factors
D004364:Pharmaceutical Preparations