[Association of L-selectin gene polymorphism with susceptibility to coronary heart disease].
OBJECTIVE
To investigate the possible association between L-selectin gene P213S polymorphism and coronary heart disease (CHD) in Chinese population.


METHODS
In total 212 CHD patients diagnosed by angiography and 230 healthy controls were studied. The genotype and allele frequencies of L-selectin gene polymorphism were assayed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).


RESULTS
The frequency of the L-selectin gene 213P allele in CHD patients was significantly higher than that in the control group (77.59% vs 69.35%, P=0.006). Compared with the SS genotype, PP homozygote had a significantly increased CHD risk (OR=2.70 and OR=2.15 using unadjusted and adjusted Logistic regression models, respectively). No association was found between the severity of CHD and the Lselectin gene P213S polymorphism


CONCLUSIONS
Our findings suggest that L-selectin gene 213P mutant allele might contribute to susceptibility of Chinese individuals to contract CHD.
Xia
Zun-en
ZE
Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan, Hubei, 430060 PR China.
Li
Yan
Y
Ming
Kai-hua
KH
Xiong
Xiao-quan
XQ
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003327:Coronary Disease / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D019041:L-Selectin / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*
D019041:L-Selectin