Modification of C2 functional group on asiatic acid and the evaluation of hepatoprotective effects.
For the development of novel hepatoprotective agents, C2 functional group on asiatic acid was modified, and evaluated for their hepatoprotective effects. Among prepared compounds, compounds 10 and 14 showed better hepatoprotective effects compared to silymarin.
Jeong
Byeong-Seon
BS
College of Pharmacy, Yeungnam University, Kyongsan 712-749, Korea.
Lee
Mi Kyeong
MK
Kim
Young Choong
YC
Lee
Eung-Seok
ES
D000818:Animals; D002251:Carbon Tetrachloride / Q000633:toxicity; D002478:Cells, Cultured; D005688:Galactosamine / Q000633:toxicity; D008099:Liver / Q000187:drug effects*; D008297:Male; D053978:Pentacyclic Triterpenes; D020011:Protective Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship; D014315:Triterpenes / Q000138:chemical synthesis / Q000494:pharmacology*
D053978:Pentacyclic Triterpenes; D020011:Protective Agents; D014315:Triterpenes; D005688:Galactosamine; C017032:asiatic acid; D002251:Carbon Tetrachloride