title: BAC consensus conference, November 4-6, 2004: epidemiology, pathogenesis, and preclinical models.
abstract: BACKGROUND
  Human bronchioloalveolar carcinoma (BAC) is a disease with an evolving definition. "Pure" BAC, characterized by a bronchioloalveolar growth pattern and no evidence of stromal, vascular, or pleural invasion, represents only 2 to 6% of non-small cell lung cancer (NSCLC) cases, but up to 20% of NSCLC cases may contain elements of BAC. This imprecise definition makes it difficult to perform epidemiologic analyses or to generate accurate animal models. However, because BAC appears to behave clinically differently from adenocarcinoma, a better understanding of this disease entity is imperative.
  
  
  RESULTS
  At the BAC Consensus Conference in 2004, our committee discussed issues relevant to BAC epidemiology, pathogenesis, and preclinical models.
  
  
  CONCLUSIONS
  Elucidation of molecular events involved in BAC tumorigenesis will allow for more precise epidemiologic studies and improved animal models, which will enable development of more effective treatments against the disease.
authors.affiliation: Harvard University Schools of Medicine and Public Health, Boston, MA, USA.
authors.forename: David C
authors.initials: DC
authors.lastname: Christiani
authors.forename: William
authors.initials: W
authors.lastname: Pao
authors.forename: James C
authors.initials: JC
authors.lastname: DeMartini
authors.forename: R Ilona
authors.initials: RI
authors.lastname: Linnoila
authors.forename: Alvin M
authors.initials: AM
authors.lastname: Malkinson
authors.forename: Amir
authors.initials: A
authors.lastname: Onn
authors.forename: Katerina A
authors.initials: KA
authors.lastname: Politi
authors.forename: Michael
authors.initials: M
authors.lastname: Sharp
authors.forename: Kwok-Kin
authors.initials: KK
authors.lastname: Wong
authors.forename: Kwok
authors.initials: K
authors.lastname: Kim
mesh_terms: D000230:Adenocarcinoma / Q000453:epidemiology / Q000473:pathology / Q000503:physiopathology; D002282:Adenocarcinoma, Bronchiolo-Alveolar / Q000453:epidemiology* / Q000473:pathology* / Q000503:physiopathology; D000818:Animals; D001707:Biopsy, Needle; D003937:Diagnosis, Differential; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000453:epidemiology* / Q000473:pathology* / Q000503:physiopathology; D008297:Male; D051379:Mice; D008819:Mice, Nude; D008822:Mice, Transgenic; D009367:Neoplasm Staging; D015995:Prevalence; D011379:Prognosis; D018570:Risk Assessment; D012756:Sheep