Survival quantitative trait locus fine mapping by measuring and testing for Hardy-Weinberg and linkage disequilibrium.
I show that fine-scale localization of a survival-related locus can be accomplished on the basis of deviations from Hardy-Weinberg equilibrium and linkage disequilibrium at closely linked marker loci. The method is based on chi(2)-tests and they can be performed for age-specific samples of alive (or dead) individuals, as for combined samples of alive and dead individuals.
Casellas
J
J
Grup de Recerca en Remugants, Departament de Ciència Animal i dels Aliments, Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain. joaquim.casellas@irta.es
D000818:Animals; D015810:Linkage Disequilibrium / Q000235:genetics*; D008957:Models, Genetic; D020161:Physical Chromosome Mapping; D040641:Quantitative Trait Loci / Q000235:genetics*; D018401:Sample Size