title: Rotavirus disease in young children from Hanoi, Vietnam.
abstract: BACKGROUND
  Pathogen prevalences and antimicrobial susceptibilities are essential for the rational development of preventive strategies for diarrheal diseases, but little recent information from Vietnam is available. We prospectively studied the prevalence of enteric pathogens in children less than 5 years of age with acute diarrhea and in nondiarrhea controls in a city hospital in Hanoi, Vietnam for 1 year.
  
  
  METHODS
  Enteric bacteria and viruses were detected by standard culture methods, and enzyme immunoassay in 291 cases and 291 controls.
  
  
  RESULTS
  Detection rates of viral pathogens among cases and controls were 31% and 3% for rotavirus, 12% and 1% for astrovirus and 4% and 1% for adenovirus. For bacterial pathogens, Aeromonas, Shigella, Salmonella, Campylobacter and enterotoxigenic E. coli were isolated from cases and controls in 15% and 8%, 9% and 1%, 7% and 1%, 4% and 0%, and 3% and 0%, respectively. The isolation of bacterial and viral pathogens except for adenovirus was significantly lower in controls than cases. Fluoroquinolones were effective against most bacterial enteropathogens, but resistance was observed in 27% of Campylobacter isolates.
  
  
  CONCLUSIONS
  Viral etiologic agents especially rotavirus were the most important cause of acute diarrhea in children less than 5 years of age in Hanoi. The burden of rotavirus in young children in Hanoi warrants consideration of using the recently released rotavirus vaccine.
authors.affiliation: Department of Enteric Diseases, Armed Forces Research Institute of Medical Sciences, Phyathai, Bangkok, Thailand. ladapornb@afrims.org
authors.forename: Ladaporn
authors.initials: L
authors.lastname: Bodhidatta
authors.forename: Nguyen Thi Phong
authors.initials: NT
authors.lastname: Lan
authors.forename: Bui Thu
authors.initials: BT
authors.lastname: Hien
authors.forename: Nong Vinh
authors.initials: NV
authors.lastname: Lai
authors.forename: Apichai
authors.initials: A
authors.lastname: Srijan
authors.forename: Oralak
authors.initials: O
authors.lastname: Serichantalergs
authors.forename: Caroline Dorworth
authors.initials: CD
authors.lastname: Fukuda
authors.forename: Phung Dac
authors.initials: PD
authors.lastname: Cam
authors.forename: Carl Jeffries
authors.initials: CJ
authors.lastname: Mason
mesh_terms: D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D003967:Diarrhea / Q000453:epidemiology / Q000382:microbiology / Q000821:virology; D005260:Female; D006090:Gram-Negative Bacteria / Q000302:isolation & purification; D016905:Gram-Negative Bacterial Infections / Q000453:epidemiology / Q000382:microbiology; D006786:Hospitals, Urban; D006801:Humans; D007223:Infant; D008297:Male; D015995:Prevalence; D012401:Rotavirus / Q000302:isolation & purification*; D012400:Rotavirus Infections / Q000453:epidemiology* / Q000821:virology; D014744:Vietnam / Q000453:epidemiology