[Effects of noopept and cortexin on the behavior of matured rats treated with corticoliberin or 70-kDa heat shock proteins in early ontogeny].
Young Wistar rats aged 4 days were injected intraperitoneally with corticotropin releasing hormone (CRH), which is an agent activating the stress system, or 70-kDa heat shock proteins (HSP-70)--intracellular shaperons, possessing antistress properties. In grown adult rats aged 90-100 days, the effects of nootropic drugs noopept and cortexin (1 mg/kg, i.p.) were assessed. The activation of stress or antistress systems with CRH or HSP-70 significantly altered the drug action. The effects were different in males and females and depended on animal gender. The spectrum of pharmacological activity of noopept and cortexin changed: noopept demonstrated preferable psychoactivating and antiaggressive effects, whereas cortexin showed mild anxiolytic and antidepressant activity. It is suggested that the behavioral effects of nootropes depend on the conditions of the stress system formation in early ontogeny.
Shabanov
P D
PD
Lebedev
A A
AA
Stetsenko
V P
VP
Lavrov
N V
NV
Sablina
G V
GV
Gudasheva
T A
TA
Ostrovaskaia
R U
RU
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D003346:Corticotropin-Releasing Hormone / Q000008:administration & dosage; D004151:Dipeptides / Q000494:pharmacology*; D005260:Female; D018840:HSP70 Heat-Shock Proteins / Q000008:administration & dosage; D036341:Intercellular Signaling Peptides and Proteins; D008297:Male; D010455:Peptides / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012737:Sex Factors; D013312:Stress, Physiological / Q000139:chemically induced / Q000523:psychology*
D004151:Dipeptides; D018840:HSP70 Heat-Shock Proteins; D036341:Intercellular Signaling Peptides and Proteins; D010455:Peptides; C103871:ethyl phenylacetyl-Pro-Gly; C056590:cortexin; D003346:Corticotropin-Releasing Hormone