Medicinal flowers. XV. The structures of noroleanane- and oleanane-type triterpene oligoglycosides with gastroprotective and platelet aggregation activities from flower buds of Camellia japonica.
The methanolic extract from the flowers buds of Camellia japonica L. (Theaceae) were found to exhibit potent inhibitory activities on ethanol- or indomethacin-induced gastric mucosal lesions in rats. Through bioassay-guided separation, 28-noroleanane-type triterpene oligoglycosides, camelliosides A, B, and C, and an oleanane-type triterpene oligoglycoside, camellioside D, were isolated from the methanolic extract together with five known compounds. The absolute stereostructures of camelliosides were determined on the basis of chemical and physicochemical evidence, which included the structure revision of the nortriterpene aglycons (camellenodiol and camelledionol). The principal oligoglycosides, camelliosides A and B, showed platelet aggregation activity in addition to the gastroprotective effects on ethanol- or indomethacin-induced gastric mucosal lesions in rats.
Yoshikawa
Masayuki
M
Kyoto Pharmaceutical University, Japan. myoshika@mb.kyoto-phu.ac.jp
Morikawa
Toshio
T
Asao
Yasunobu
Y
Fujiwara
Emi
E
Nakamura
Seikou
S
Matsuda
Hisashi
H
D000818:Animals; D028244:Camellia / Q000737:chemistry*; D035264:Flowers / Q000737:chemistry*; D006027:Glycosides / Q000737:chemistry*; D008297:Male; D008958:Models, Molecular; D015394:Molecular Structure; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D011817:Rabbits; D051381:Rats; D017207:Rats, Sprague-Dawley; D013057:Spectrum Analysis / Q000379:methods; D013276:Stomach Ulcer / Q000517:prevention & control*; D014315:Triterpenes / Q000737:chemistry*
D006027:Glycosides; D010975:Platelet Aggregation Inhibitors; D014315:Triterpenes