title: Enhanced cell-to-cell contacts between activated microglia and pyramidal cell dendrites following kainic acid-induced neurotoxicity in the hippocampus.
abstract: Microglia participate in immune responses in the brain. However, little is known about the contact-mediated interaction between microglia and neurons. We report here that the cell-to-cell contacts between microglial processes and dendrites of hippocampal CA1 neurons were dramatically increased in density and area following local injection of kainic acid (KA). A similar KA-induced increase in the degree of intercellular contacts was observed in mice lacking telencephalin (TLCN), a neuronal dendritic adhesion molecule of ICAM family. The results suggest that adhesive contacts independent of TLCN and contact-mediated interactions between microglia and dendrites were promoted by excitotoxic brain injury.
authors.affiliation: Department of Physiology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
authors.forename: Sanae
authors.initials: S
authors.lastname: Hasegawa
authors.forename: Masahiro
authors.initials: M
authors.lastname: Yamaguchi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nagao
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Mishina
authors.forename: Kensaku
authors.initials: K
authors.lastname: Mori
mesh_terms: D000818:Animals; D002135:Calcium-Binding Proteins / Q000378:metabolism; D002450:Cell Communication / Q000187:drug effects*; D002452:Cell Count / Q000379:methods; D003712:Dendrites / Q000187:drug effects*; D037502:Galectin 3 / Q000378:metabolism; D006624:Hippocampus / Q000166:cytology* / Q000187:drug effects; D007608:Kainic Acid / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008840:Microfilament Proteins; D017628:Microglia / Q000187:drug effects* / Q000502:physiology; D008959:Models, Neurological; D009498:Neurotoxins / Q000494:pharmacology*; D017966:Pyramidal Cells / Q000166:cytology*; D013997:Time Factors
chemical_list: C491049:Aif1 protein, mouse; D002135:Calcium-Binding Proteins; D037502:Galectin 3; D008840:Microfilament Proteins; D009498:Neurotoxins; D007608:Kainic Acid