The P239S palladin variant does not account for a significant fraction of hereditary or early onset pancreas cancer.
The P239S palladin variant has recently been suggested to play a role in hereditary pancreatic cancer. We estimated the contribution of the P239S variant, and surrounding sequence, to familial and early-onset pancreatic cancer. The P239S germline variant was identified in one of 84 high-risk cases and one of 555 controls. The case reported an elderly relative with pancreas cancer. We conclude that this variant does not appear to account for a significant fraction of hereditary or early-onset pancreas cancer.
Zogopoulos
George
G
Sam Minuk Cancer Genetics and Biomarker Laboratories, Samuel Lunenfeld Research Institute, Toronto, Ontario, Canada.
Rothenmund
Heidi
H
Eppel
Ayelet
A
Ash
Colleen
C
Akbari
Mohammad Reza
MR
Hedley
David
D
Narod
Steven A
SA
Gallinger
Steven
S
D000368:Aged; D003598:Cytoskeletal Proteins / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D010190:Pancreatic Neoplasms / Q000235:genetics*; D010750:Phosphoproteins / Q000235:genetics*
D003598:Cytoskeletal Proteins; C412722:PALLD protein, human; D010750:Phosphoproteins