Glutathione and associated enzymes in toxic cataractogenesis-selenite model.
Glutathione, gamma-glutamyl cysteine synthetase (gamma -GCS) and glutathione reductase (GSH-R) activity were determined biochemically in the lens during various stages after subcutaneous administration of sodium selenite in multiple low dosages and single high dosages. The GSH concentration and gamma-GCS and GSH-R activity declined progressively after the selenite administration. The changes observed were discussed in relation to the possible role of selenite interaction with GSH and the enzymes.
Mathew
Joe Prasad
JP
Department of Zoology, St. Berchmans' College, Changanacherry - 686 101, India. jopmat@rediffmail.com
Joseph
Priya
P
Thomas
V C
VC
Thomas
Issac
I
D000818:Animals; D002386:Cataract / Q000139:chemically induced / Q000201:enzymology* / Q000378:metabolism; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005260:Female; D005721:Glutamate-Cysteine Ligase / Q000378:metabolism*; D005978:Glutathione / Q000378:metabolism*; D005980:Glutathione Reductase / Q000378:metabolism; D007908:Lens, Crystalline / Q000201:enzymology / Q000378:metabolism; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D018038:Sodium Selenite / Q000633:toxicity*
D005980:Glutathione Reductase; D005721:Glutamate-Cysteine Ligase; D005978:Glutathione; D018038:Sodium Selenite