title: [Cerebrovascular disease and diabetes mellitus].
abstract: In Japan, individuals with diabetes mellitus have been increasing rapidly. A population -based study, conducted in a Japanese community, Hisayama, in 1988, showed that among subjects aged 40 to 79 years, the prevalence of glucose intolerance: namely impaired fasting glycemia, impaired glucose tolerance, and diabetes, exceeded 40% in men and 30% in women. Previous cohort studies in the world demonstrated that the multivariate -adjusted relative risks of stroke (cerebral infarction) for diabetes were significantly high and ranged from 2 to 5. Diabetes induces various types of cerebral infarction and significantly increases the recurrence and mortality rates after first episode of stroke. Hyperglycemia and insulin resistance observed in diabetes cause arteriosclerosis through various mechanisms, resulting in the development of stroke.
authors.affiliation: Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Kiyohara
mesh_terms: D000328:Adult; D000368:Aged; D002561:Cerebrovascular Disorders / Q000209:etiology*; D048909:Diabetes Complications; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged