title: The matrix comes to lung transplantation.
abstract: Lung transplantation is complicated by fibroproliferation, which is likely mediated in part by matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs. This commentary briefly discusses what is known about these mediators in fibrotic pulmonary diseases and how an important new study by Yoshida and colleagues sheds light on the diverse functions of these proteins in alloimmune inflammation.
authors.affiliation: Department of Surgery, University of Colorado Health Sciences Center, Denver, CO 80262, USA.
authors.forename: Ashok N
authors.initials: AN
authors.lastname: Babu
authors.forename: Mark R
authors.initials: MR
authors.lastname: Nicolls
mesh_terms: D015551:Autoimmunity / Q000502:physiology*; D006084:Graft Rejection / Q000209:etiology / Q000276:immunology; D006801:Humans; D016040:Lung Transplantation / Q000276:immunology*; D061965:Matrix Metalloproteinase Inhibitors; D020782:Matrix Metalloproteinases / Q000502:physiology*; D011014:Pneumonia / Q000276:immunology / Q000503:physiopathology; D011658:Pulmonary Fibrosis / Q000276:immunology / Q000503:physiopathology*; D019714:Tissue Inhibitor of Metalloproteinases / Q000502:physiology
chemical_list: D061965:Matrix Metalloproteinase Inhibitors; D019714:Tissue Inhibitor of Metalloproteinases; D020782:Matrix Metalloproteinases