Hydrolyzed metabolites of thalidomide: synthesis and TNF-alpha production-inhibitory activity.
Putative hydrolyzed metabolites of thalidomide were prepared and characterized, and their inhibitory activity on tumor necrosis factor (TNF)-alpha production in the human monocytic leukemia cell line THP-1 was evaluated. Alpha-(2-Carboxybenzamido)glutarimide was a more potent TNF-alpha production inhibitor than thalidomide.
Nakamura
Takanori
T
Institute of Molecular & Cellular Biosciences, The University of Tokyo, Japan.
Noguchi
Tomomi
T
Miyachi
Hiroyuki
H
Hashimoto
Yuichi
Y
D006868:Hydrolysis; D009682:Magnetic Resonance Spectroscopy; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013792:Thalidomide / Q000378:metabolism*; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors* / Q000096:biosynthesis*
D014409:Tumor Necrosis Factor-alpha; D013792:Thalidomide