Serum adiponectin and leptin in a patient with Cushing's syndrome before and after adrenalectomy.
We measured the serum adiponectin and leptin concentrations before and after successful removal of a left adrenal adenoma in a 46-year-old woman with Cushing's syndrome. The serum adiponectin level was 6.0 microg/ml before the operation and rose to 8.1 microg/ml after adrenalectomy. However, the serum leptin level was markedly high (24.8 ng/ml) before the operation and decreased to within the normal range (6.0 ng/ml) 6 months after adrenalectomy, concomitant with weight reduction and normalization of the serum cortisol level.
Ashizawa
Naoto
N
Division of Cardiovascular Medicine, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
Takagi
Mayuko
M
Seto
Shinji
S
Suzuki
Shin
S
Yano
Katsusuke
K
D000236:Adenoma / Q000097:blood / Q000175:diagnosis / Q000601:surgery*; D052242:Adiponectin / Q000097:blood*; D000310:Adrenal Gland Neoplasms / Q000097:blood / Q000175:diagnosis / Q000601:surgery*; D000315:Adrenalectomy / Q000379:methods; D015415:Biomarkers / Q000097:blood; D001774:Blood Chemical Analysis; D003480:Cushing Syndrome / Q000097:blood / Q000175:diagnosis / Q000601:surgery*; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood*; D008875:Middle Aged; D011184:Postoperative Period; D011300:Preoperative Care; D012680:Sensitivity and Specificity; D016896:Treatment Outcome
D052242:Adiponectin; D015415:Biomarkers; D020738:Leptin