title: Effect of alcohol consumption on leptin level in serum, adipose tissue, and gastric mucosa.
abstract: It has been reported that the stomach is a source of leptin, which is the product of the obese (ob) gene. In the present study, the effect of alcohol on leptin level in serum, gastric mucosa, and adipose tissue was studied to understand the relationship between appetite and alcohol consumption. Male Sprague-Dawley rats were administered 1 ml of 25% ethanol perorally. Leptin levels in the serum, gastric mucosa, and adipose tissue were measured. The serum leptin level was significantly decreased 3 and 6 hr after ethanol administration, although the gastric leptin level was not affected. The leptin level in the adipose tissue was significantly increased 3 hr after administration. We conclude that the decreased serum leptin level after ethanol administration might be due to suppression of leptin secretion from adipose tissue to the systemic circulation. These findings might be important for understanding the relationship between alcohol consumption and appetite.
authors.affiliation: Department of Internal Medicine and Gastroenterology, Akita University School of Medicine, 1-1-1 Hondo, Akita 010-8543, Japan. otaka@med.akita-u.ac.jp
authors.forename: Michiro
authors.initials: M
authors.lastname: Otaka
authors.forename: Noriaki
authors.initials: N
authors.lastname: Konishi
authors.forename: Masaru
authors.initials: M
authors.lastname: Odashima
authors.forename: Mario
authors.initials: M
authors.lastname: Jin
authors.forename: Isao
authors.initials: I
authors.lastname: Wada
authors.forename: Tamotsu
authors.initials: T
authors.lastname: Matsuhashi
authors.forename: Reina
authors.initials: R
authors.lastname: Ohba
authors.forename: Sumio
authors.initials: S
authors.lastname: Watanabe
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D000284:Administration, Oral; D000428:Alcohol Drinking / Q000009:adverse effects / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D015415:Biomarkers / Q000097:blood / Q000378:metabolism; D002492:Central Nervous System Depressants / Q000008:administration & dosage; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004797:Enzyme-Linked Immunosorbent Assay; D000431:Ethanol / Q000008:administration & dosage*; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D020738:Leptin / Q000097:blood / Q000378:metabolism*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D015415:Biomarkers; D002492:Central Nervous System Depressants; D020738:Leptin; D000431:Ethanol