title: Prognostic value of serum free light chain ratio at diagnosis in multiple myeloma.
abstract: The prognostic value of baseline serum free light chain ratio (sFLCR) was investigated in 94 multiple myeloma (MM) patients. sFLCR was calculated as kappa/lambda or lambda/kappa, depending on the patients' dominating monoclonal light chain. Median baseline sFLCR was 3.57 in kappa-MM patients, 45.09 in lambda-MM. 'High' sFLCR (> or = the observed median value for kappa- and lambda-MM respectively) correlated with elevated serum creatinine and lactate dehydrogenase, extensive marrow infiltration and light chain type MM. The 5-year disease-specific survival was 82% and 30% in patients with sFLCR lower than and equal or greater than the median, respectively (P = 0.0001). sFLCR was an independent prognostic factor.
authors.affiliation: Department of Haematology, National and Kapodistrian University of Athens, Laikon General Hospital, Athens, Greece.
authors.forename: Marie-Christine
authors.initials: MC
authors.lastname: Kyrtsonis
authors.forename: Theodoros P
authors.initials: TP
authors.lastname: Vassilakopoulos
authors.forename: Nicoletta
authors.initials: N
authors.lastname: Kafasi
authors.forename: Sotirios
authors.initials: S
authors.lastname: Sachanas
authors.forename: Tatiana
authors.initials: T
authors.lastname: Tzenou
authors.forename: Argiroula
authors.initials: A
authors.lastname: Papadogiannis
authors.forename: Zacharoula
authors.initials: Z
authors.lastname: Galanis
authors.forename: Christina
authors.initials: C
authors.lastname: Kalpadakis
authors.forename: Maria
authors.initials: M
authors.lastname: Dimou
authors.forename: Elias
authors.initials: E
authors.lastname: Kyriakou
authors.forename: Maria K
authors.initials: MK
authors.lastname: Angelopoulou
authors.forename: Maria N
authors.initials: MN
authors.lastname: Dimopoulou
authors.forename: Marina P
authors.initials: MP
authors.lastname: Siakantaris
authors.forename: Evangelia M
authors.initials: EM
authors.lastname: Dimitriadou
authors.forename: Styliani I
authors.initials: SI
authors.lastname: Kokoris
authors.forename: Panayiotis
authors.initials: P
authors.lastname: Panayiotidis
authors.forename: Gerassimos A
authors.initials: GA
authors.lastname: Pangalis
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D001853:Bone Marrow / Q000473:pathology; D003404:Creatinine / Q000097:blood; D005260:Female; D006801:Humans; D007147:Immunoglobulin Light Chains / Q000097:blood*; D007145:Immunoglobulin kappa-Chains / Q000097:blood; D007146:Immunoglobulin lambda-Chains / Q000097:blood; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000097:blood / Q000175:diagnosis* / Q000401:mortality; D011379:Prognosis; D016019:Survival Analysis
chemical_list: D015415:Biomarkers; D007147:Immunoglobulin Light Chains; D007145:Immunoglobulin kappa-Chains; D007146:Immunoglobulin lambda-Chains; D003404:Creatinine; D007770:L-Lactate Dehydrogenase