The isolation of secondary metabolites and in vitro potent anti-cancer activity of clerodermic acid from Enicosanthum membranifolium.
Four compounds were isolated from Enicosanthum membranifolium. The structures of the compounds were confirmed by spectroscopic data. Their structures were determined as N-trans-feruloyltyramine, R-(-)-mellein, clerodermic acid, and salicifoline chloride as a quaternary alkaloid compound. The structures of R-(-)-mellein and salicifoline chloride were confirmed by using X-ray diffraction. Clerodermic acid was shown to induce potent apoptosis against human leukemia HL60 cells.
Efdi
Mai
M
Department of Chemistry, Faculty of Engineering, Gifu University, Gifu 501-1193, Japan.
Itoh
Tomohiro
T
Akao
Yukihiro
Y
Nozawa
Yoshinori
Y
Koketsu
Mamoru
M
Ishihara
Hideharu
H
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D029061:Annonaceae / Q000378:metabolism*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D003373:Coumaric Acids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D049934:Isocoumarins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D009281:Naphthalenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D009793:Ochratoxins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D014407:Tumor Cells, Cultured; D014439:Tyramine / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
D000470:Alkaloids; D000970:Antineoplastic Agents; D003373:Coumaric Acids; D049934:Isocoumarins; D007783:Lactones; D009281:Naphthalenes; D009793:Ochratoxins; C521389:clerodermic acid; C074004:feruloyltyramine; C058227:salicifoline; D014439:Tyramine; C120538:ochracin