Biomarkers of exposure to carcinogenic PAHs and their relationship with environmental factors.
The EXPAH project is a multicentre European study in which biomarkers of exposure, biomarkers of effect, genetic susceptibility and environmental factors were studied in populations exposed to differing levels of carcinogenic polycyclic aromatic hydrocarbons (c-PAHs). We describe here the relationships between the levels of DNA adducts (as biomarkers of exposure), the exposure to air pollution and smoking status. Lymphocyte bulky DNA adducts were significantly correlated with exposure when subjects were classified either by job description or by personal monitor measurements, and both bulky and benzo(a)pyrene (B[a]P) DNA adducts were also correlated with smoking status. These associations varied across the countries studied (Czech Republic, Slovakia, Bulgaria). Results from a multivariate analysis show that factors mainly contributing to bulky and B[a]P DNA adducts are age, smoking habit, country of origin and environmental exposure to c-PAHs. The B[a]P DNA adducts were more strongly associated with smoking status than with the environmental exposure to c-PAHs.
Taioli
Emanuela
E
University of Pittsburgh Cancer Center, 5150 Centre Avenue, Pittsburgh, PA 15232, USA. taiolien@upmc.edu
Sram
Radim J
RJ
Binkova
Blanka
B
Kalina
Ivan
I
Popov
Todor A
TA
Garte
Seymour
S
Farmer
Peter B
PB
D000393:Air Pollutants / Q000633:toxicity*; D001564:Benzo(a)pyrene / Q000032:analysis; D015415:Biomarkers; D002274:Carcinogens, Environmental / Q000633:toxicity*; D018736:DNA Adducts / Q000032:analysis; D004784:Environmental Monitoring; D006801:Humans; D008297:Male; D015999:Multivariate Analysis; D016273:Occupational Exposure; D011084:Polycyclic Aromatic Hydrocarbons / Q000633:toxicity*; D012907:Smoking / Q000009:adverse effects
D000393:Air Pollutants; D015415:Biomarkers; D002274:Carcinogens, Environmental; D018736:DNA Adducts; D011084:Polycyclic Aromatic Hydrocarbons; C056612:benzo(a)pyrene-DNA adduct; D001564:Benzo(a)pyrene