title: Esophagitis in frail elderly people.
abstract: BACKGROUND
  We studied the clinical course of elderly patients acutely hospitalized for various diseases, assessing any differences between patients with and without esophagitis.
  
  
  METHODS
  A case-control study on the presence of esophagitis was conducted on the clinical records of all in-patients undergoing gastroduodenoscopy at Padova Geriatric Hospital from 1997 to 2001. Data were examined on 338 sex-matched patients: 169 with a diagnosis of esophagitis and 169 with a negative endoscopy.
  
  
  RESULTS
  Admissions for acute respiratory disorders [odds ratios (OR) 2.68; 95% confidence interval (CI) 0.89-8.01], a remote diagnosis of esophagitis (OR 11.34; 95%CI 2.68-48.07), obesity (OR 3.36; 95%CI 0.91-12.48), and being bedridden (OR 6.84; 95%CI 3.27-14.29) were found to be independent risk factors for the presence of esophagitis. The symptoms prompting the endoscopic diagnoses included: gastrointestinal bleeding (OR 7.61; 95%CI 2.76-21.0), heartburn (OR 4.58; 95%CI 1.86-11.28), and cough (OR 3.59; 95%CI 1.34-9.62). Steroids (OR 2.68; 95%CI 1.11-6.44) and calcium antagonists (OR 1.50; 95%CI 0.79-2.87) were associated with esophagitis as risk factors, whereas proton pump inhibitors (OR 0.46; 95%CI 0.25-0.87), nitrates (OR 0.14; 95%CI 0.02-0.78), and sucralfate in males (OR 0.09; 95%CI 0.01-0.92) were associated as protective factors. Patients with esophagitis were discharged with an endocrinologic/metabolic-type diagnosis. Deaths were significantly higher among patients with esophagitis (25 vs. 9); more severe esophagitis was characterized by a higher Charlson comorbidity index and a greater presence of anorexia and nausea.
  
  
  CONCLUSIONS
  These findings seem to substantiate the theory that esophagitis is a characteristic which exacerbates frailty in hospitalized elderly people and its identification may be helpful in these patients.
authors.affiliation: Geriatric Department, Division of Geriatric Surgery, University of Padova, Padova, Italy. word.online@tin.it
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Cardin
authors.forename: Nadia
authors.initials: N
authors.lastname: Minicuci
authors.forename: Paola
authors.initials: P
authors.lastname: Siviero
authors.forename: Serena
authors.initials: S
authors.lastname: Bertolio
authors.forename: Giulia
authors.initials: G
authors.lastname: Gasparini
authors.forename: Emine Meral
authors.initials: EM
authors.lastname: Inelmen
authors.forename: Oreste
authors.initials: O
authors.lastname: Terranova
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D015897:Comorbidity; D016145:Endoscopy, Digestive System; D004941:Esophagitis / Q000453:epidemiology*; D005260:Female; D016330:Frail Elderly; D006760:Hospitalization; D006801:Humans; D008171:Lung Diseases / Q000453:epidemiology; D008297:Male; D051346:Mobility Limitation; D009765:Obesity / Q000453:epidemiology; D012307:Risk Factors