title: Antibacterial and cytotoxic activity of the acetone extract of the flowers of Salvia sclarea and some natural products.
abstract: The aim of this study was to investigate the antibacterial and the cytotoxic activity of the acetone extract of the flowers of Salvia sclarea and of some natural products (sclareol, sclareolide and ambrox). The antibacterial and the cytotoxic activity were determined by the dilution method. Sclareolide, ambrox and sclareol demonstrated a good antibacterial activity against Staphylococcus aureus ATCC 25923, Pseudomonas aeruginosa ATCC 27950, Escherichia coli ATCC 25922 and Enterococcus faecalis ATCC 29212. The acetonic extract of the flowers of Salvia sclarea has a significant cytotoxic activity against Hep-2 cells.
authors.affiliation: Laboratoire des substances biologiquement actives et des maladies transmissibles Faculté de Pharmacie-500-Monastir-Tunisia. hayetjaziri@yahoo.fr
authors.forename: Edziri
authors.initials: E
authors.lastname: Hayet
authors.forename: Bannour
authors.initials: B
authors.lastname: Fatma
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Souhir
authors.forename: Fekih Abdel
authors.initials: FA
authors.lastname: Waheb
authors.forename: Kenani
authors.initials: K
authors.lastname: Abderaouf
authors.forename: Aouni
authors.initials: A
authors.lastname: Mahjoub
authors.forename: Mastouri
authors.initials: M
authors.lastname: Maha
mesh_terms: D000096:Acetone / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004224:Diterpenes / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D013293:Enterococcus faecalis / Q000187:drug effects / Q000254:growth & development; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development; D035264:Flowers; D005663:Furans / Q000494:pharmacology*; D006801:Humans; D020128:Inhibitory Concentration 50; D008113:Liver Neoplasms / Q000473:pathology; D008826:Microbial Sensitivity Tests; D009281:Naphthalenes / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000254:growth & development; D027544:Salvia; D012997:Solvents / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development
chemical_list: D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D004224:Diterpenes; D005663:Furans; D009281:Naphthalenes; D010936:Plant Extracts; D012997:Solvents; D000096:Acetone; C109395:sclareolide; C413580:ambrox; C070760:sclareol