Parallel synthesis of a novel C2-aryl pyrrolo[2,1-c][1,4]benzodiazepine (PBD) library.
A 66-member C2-aryl pyrrolo[2,1-c][1,4]benzodiazepine (PBD) library has been successfully synthesized in parallel via Suzuki coupling using PS-PPh3Pd (catalyst) and PS-DEAM (scavenger) under microwave radiation. Library members were obtained in sufficient yield (up to 91%) and purity (85-98% crude) for biological evaluation.
Antonow
Dyeison
D
Spirogen Limited, 2 Royal College Street, London NW1 0NH, UK.
Cooper
Nectaroula
N
Howard
Philip W
PW
Thurston
David E
DE
D001569:Benzodiazepines / Q000138:chemical synthesis* / Q000737:chemistry / Q000528:radiation effects; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D008872:Microwaves; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry; D010165:Palladium / Q000737:chemistry; D013237:Stereoisomerism
D009942:Organometallic Compounds; D001569:Benzodiazepines; D010165:Palladium