Outcome of a national Israeli cohort of pediatric systemic lupus erythematosus.
The aim of this study was to describe the clinical manifestations and outcomes of a national cohort of childhood systemic lupus erythematosus (cSLE). All cases of cSLE registered in the Israeli national registry of children with rheumatic diseases between 1987-2003 were examined for disease activity and damage by the SLE disease activity index (SLEDAI) and SLE collaborating clinics/American College of Rheumatology (SLICC/ACR) damage index. Demographic, clinical, laboratory and treatment factors were analysed for their effect on the outcome. One-hundred and two patients were identified, 81% females, with a mean age at diagnosis of 13.3 +/- 2.6 years. The mean SLEDAI score was 17.2 +/- 9.0 (range 2-60). Fifty four patients were followed for at least five years. The mean SLEDAI decreased to 7.6 +/- 6.3 (0-29) and the mean SLICC/ACR damage index was 0.7 +/- 1.6 (0-8). Five patients developed chronic renal failure. No patients died. No factors were found to be significantly associated with the outcome except the initial SLEDAI score. The five-year outcome of our national cSLE cohort was good; with relatively low activity and minimal damage in most patients. The initial SLEDAI predicted the development of late damage.
Uziel
Y
Y
Department of Pediatrics, Meir Medical Center, Tel Aviv University Kfar-Saba, Isreal. uziely@zahav.net.il
Gorodnitski
N
N
Mukamel
M
M
Padeh
S
S
Brik
R
R
Barash
J
J
Mevorach
D
D
Berkun
Y
Y
Tauber
T
T
Press
J
J
Harel
L
L
Navon
P
P
Rubenstein
M
M
Naparstek
Y
Y
Hashkes
P J
PJ
D000293:Adolescent; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007557:Israel; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis* / Q000188:drug therapy*; D008297:Male; D012042:Registries