Epidemiologic distribution of the arginine catabolic mobile element among selected methicillin-resistant and methicillin-susceptible Staphylococcus aureus isolates.
We tested 214 Staphylococcus aureus isolates for the arcA locus of the arginine catabolic mobile element (ACME). All USA300 SCCmec IVa isolates, but no isolates containing other SCCmec subtypes, were arcA positive. arcA was also detected in selected methicillin-susceptible USA300 and methicillin-resistant USA100 isolates. DNA sequence analysis confirmed the integration of ACME in orfX.
Goering
Richard V
RV
Department of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, NE 68178, USA. rgoeri@creighton.edu
McDougal
Linda K
LK
Fosheim
Greg E
GE
Bonnstetter
Kristin K
KK
Wolter
Daniel J
DJ
Tenover
Fred C
FC
D001120:Arginine / Q000378:metabolism*; D001483:Base Sequence; D016521:Electrophoresis, Gel, Pulsed-Field; D006801:Humans; D020071:Interspersed Repetitive Sequences / Q000235:genetics*; D008712:Methicillin / Q000494:pharmacology*; D016106:Methicillin Resistance / Q000235:genetics; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D013203:Staphylococcal Infections / Q000453:epidemiology* / Q000382:microbiology; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000235:genetics
D001120:Arginine; D008712:Methicillin