title: GSTT1 and GSTM1 null genotypes may facilitate hepatitis C virus infection becoming chronic.
abstract: Oxidative stress contributes to hepatitis C virus (HCV)-induced liver damage. The activity of antioxidant glutathione S-transferases (GSTs) T1 and M1 is polymorphic. The GSTT1 and GSTM1 genotypes were identified in 139 HCV-infected patients and in 329 healthy individuals. Among patients, there was an excess of GSTT1 (odds ratio [OR], 2.76 [95% confidence interval [CI], 1.77-4.30]; P<.001) and GSTM1 (OR, 1.54 [95% CI, 1.02-2.35]; P=.032) null genotypes and of double-null haplotypes (OR, 3.65 [95% CI, 1.98-6.75]; P<.001). The GSTT1 null genotype, particularly if associated with the GSTM1 null genotype, may facilitate HCV infection becoming chronic.
authors.affiliation: Department of Pharmacology and Psychiatry, University of Extremadura, Badajoz, Spain.
authors.forename: Carmen
authors.initials: C
authors.lastname: Martínez
authors.forename: Elena
authors.initials: E
authors.lastname: García-Martín
authors.forename: José M
authors.initials: JM
authors.lastname: Ladero
authors.forename: Oscar
authors.initials: O
authors.lastname: Herráez
authors.forename: Luis
authors.initials: L
authors.lastname: Ortega
authors.forename: Carlos
authors.initials: C
authors.lastname: Taxonera
authors.forename: Avelina
authors.initials: A
authors.lastname: Suárez
authors.forename: Manuel
authors.initials: M
authors.lastname: Díaz-Rubio
authors.forename: José A G
authors.initials: JA
authors.lastname: Agúndez
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D015331:Cohort Studies; D018450:Disease Progression; D005260:Female; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics*; D016174:Hepacivirus / Q000201:enzymology* / Q000235:genetics*; D019698:Hepatitis C, Chronic / Q000473:pathology / Q000821:virology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013030:Spain; D044465:White People / Q000235:genetics
chemical_list: D005982:Glutathione Transferase; C413545:glutathione S-transferase T1