Metal carbonyls as pharmaceuticals? [Ru(CO)3Cl(glycinate)], a CO-releasing molecule with an extensive aqueous solution chemistry.
The pharmacologically active [Ru(CO)(3)Cl(glycinate)] is shown to be in equilibrium with [Ru(CO)(2)(CO(2)H)Cl(glycinate)](-) (isomers) at around pH 3.1 which then at physiological pH reacts with more base to give [Ru(CO)(2)(CO(2))Cl(glycinate)](2-) (isomers) or [Ru(CO)(2)(CO(2)H)(OH)(glycinate)](-) (isomers). The ease with which [Ru(CO)(3)Cl(glycinate)] reacts with hydroxide results in it producing a solution in water with a pH of around 2 to 2.5 depending on concentration and making its solutions more acidic than those of acetic acid at comparable concentrations. Acidification of [Ru(CO)(3)Cl(glycinate)] with HCl gives [Ru(CO)(3)Cl(2)(NH(2)CH(2)CO(2)H)]. The crystal structures of [Ru(CO)(3)Cl(glycinate)] and [Ru(CO)(3)Cl(2)(NH(2)CH(2)CO(2)Me)] are reported.
Johnson
Tony R
TR
Department of Chemistry, University of Sheffield, Sheffield, S3 7HF, UK.
Mann
Brian E
BE
Teasdale
Ian P
IP
Adams
Harry
H
Foresti
Roberta
R
Green
Colin J
CJ
Motterlini
Roberto
R
D002248:Carbon Monoxide / Q000737:chemistry*; D018360:Crystallography, X-Ray; D005998:Glycine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D012428:Ruthenium / Q000737:chemistry*; D012996:Solutions; D013055:Spectrophotometry, Infrared; D014867:Water / Q000737:chemistry
D009942:Organometallic Compounds; D012996:Solutions; D014867:Water; D002248:Carbon Monoxide; D012428:Ruthenium; D005998:Glycine