Amyloid beta-protein and lipid metabolism.
Lipids play an important part as risk or protective factors for Alzheimer's disease. This review summarizes the current findings in which lipids influence Alzheimer's disease and introduces the molecular mechanism how these lipids are linked to amyloid production. Besides the pathological impact of amyloid in Alzheimer's disease, amyloid has a physiological function in regulating lipid homeostasis in return. The understanding of the resulting regulatory cycles between amyloid precursor protein processing and lipids provides a platform for the development of new causal therapeutic approaches for Alzheimer's disease.
Zinser
Eva G
EG
Universität des Saarlandes, Uniklinikum Homburg, Neurobiologie, Neurologie, Gebäude 90, 66421 Homburg/Saar, Germany.
Hartmann
Tobias
T
Grimm
Marcus O W
MO
D000544:Alzheimer Disease / Q000378:metabolism* / Q000473:pathology / Q000628:therapy; D016564:Amyloid beta-Protein Precursor; D000818:Animals; D006706:Homeostasis; D006801:Humans; D050356:Lipid Metabolism; D011499:Protein Processing, Post-Translational; D012307:Risk Factors
D016564:Amyloid beta-Protein Precursor