[Topical enzyme-based formulations].
Research studies aimed at improving the enzyme catalytic efficiency and operational stability are considered as a recurrent challenge with topical enzyme-based formulations. A large number of plant and bacterial proteolytic enzymes have been studied as an early substitutive replacement for the mechanical debridement of partial-thickness burns. In addition, progress in protein engineering and vectorisation of drugs provide improvements in the approach of topical and photoprotective enzyme therapy.
Boudry
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Centre de Recherches du Service de Santé des Armées (CRSSA), Département de toxicologie, 24, avenue du marquis du Grésivaudan, BP 87, F 38702 La Tronche Cedex. iboudry@crssa.net
D000287:Administration, Topical; D000818:Animals; D002626:Chemistry, Pharmaceutical; D057487:Enzyme Therapy; D004798:Enzymes / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D010447:Peptide Hydrolases / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D012871:Skin Diseases / Q000188:drug therapy
D004798:Enzymes; D010447:Peptide Hydrolases