title: Synthesis, characterization of Ag(I), Pd(II) and Pt(II) complexes of a triazine-3-thione and their interactions with bovine serum albumin.
abstract: Ag(I), Pd(II) and Pt(II) complexes of 5-methoxy-5,6-diphenyl-4,5-dihydro-2H-[1,2,4]triazine-3-thione (LH(2)OCH(3)) have been synthesized and characterized by elemental analysis, molar conductance, (1)H NMR, IR spectra, UV spectra and thermal analysis (TG-DTA). The components of the three complexes are [Ag(C(15)H(10)N(3)S)](6), Pd(C(15)H(10)N(3)S)(2) and Pt(C(15)H(10)N(3)S)(2).C(3)H(6)O.2H(2)O, respectively. All the complexes are nonelectrolyte and have high thermodynamic stability. The ligand may act as bidentate NS donor for Pd(II) and Pt(II) complexes, while it seems to be bidentate NS bridging via sulphur atom for Ag(I) complex. A planar quadrangular structure is proposed for Pd(II) and Pt(II) complexes and Ag(I) complex may be a hexanuclear cluster. Their interactions with bovine serum albumin (BSA) are investigated using steady state fluorescence technology. It is observed that all of them can quench the intrinsic fluorescence of BSA through static quenching procedure. The binding constants (K(A)) at different temperatures, thermodynamic parameters enthalpy changes (DeltaH) and entropy changes (DeltaS) between BSA and the compounds are calculated. Based on the values of DeltaH and DeltaS, it is judged that the main acting force of PtL(2).C(3)H(6)O.2H(2)O with BSA may be electrostatic interaction, and for the LH(2)OCH(3), Ag(6)L(6) and PdL(2), hydrophobic and electrostatic interactions may be involved in their binding processes.
authors.affiliation: School of Chemistry and Environmental Science, Key Laboratory for Environmental Pollution Control Technology of Henan Province, Henan Normal University, Xinxiang, Henan, China. zhangxyemail@126.com
authors.forename: Xiuying
authors.initials: X
authors.lastname: Zhang
authors.forename: Shuyan
authors.initials: S
authors.lastname: Li
authors.forename: Lin
authors.initials: L
authors.lastname: Yang
authors.forename: Changqing
authors.initials: C
authors.lastname: Fan
mesh_terms: D000818:Animals; D002417:Cattle; D007700:Kinetics; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D019216:Metals, Heavy / Q000378:metabolism*; D010165:Palladium / Q000378:metabolism; D010984:Platinum / Q000378:metabolism; D012710:Serum Albumin, Bovine / Q000737:chemistry / Q000378:metabolism*; D012834:Silver / Q000378:metabolism; D013055:Spectrophotometry, Infrared; D013816:Thermodynamics; D013871:Thiones / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism*; D014227:Triazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism*
chemical_list: D008024:Ligands; D019216:Metals, Heavy; D013871:Thiones; D014227:Triazines; D012710:Serum Albumin, Bovine; D012834:Silver; D010984:Platinum; D010165:Palladium