A guide to murine fibrinolytic factor structure, function, assays, and genetic alterations.
The components and functions of the murine fibrinolytic system are quite similar to those of humans. Because of these similarities and the adaptability of mice to genetic manipulation, murine fibrinolysis has been studied extensively. These studies have yielded important information regarding the function of the several components of fibrinolysis. This review presents information on the structure, function and assay of mouse fibrinolytic parameters and it discusses the results of the extensive studies of genetically modified mice. It is intended to be a convenient reference resource for investigators of fibrinolysis.
Matsuo
O
O
Department of Physiology, Kinki University School of Medicine, Osakasayama, Japan.
Lijnen
H R
HR
Ueshima
S
S
Kojima
S
S
Smyth
S S
SS
D000818:Animals; D004195:Disease Models, Animal; D005340:Fibrinogen / Q000737:chemistry / Q000378:metabolism*; D005342:Fibrinolysis; D005343:Fibrinolytic Agents / Q000737:chemistry*; D006487:Hemostasis; D006801:Humans; D007700:Kinetics; D051379:Mice; D008954:Models, Biological; D008957:Models, Genetic; D010958:Plasminogen / Q000235:genetics / Q000502:physiology*; D010960:Plasminogen Activators / Q000235:genetics / Q000502:physiology*; D013045:Species Specificity
D005343:Fibrinolytic Agents; D005340:Fibrinogen; D010958:Plasminogen; D010960:Plasminogen Activators