title: Retinal complications in patients with solid organ or bone marrow transplantations.
abstract: BACKGROUND
  The administration of systemic immunosuppressive agents to recipients of solid organ or bone marrow transplants results in an immunocompromised status. As the number of organ recipients and their life span increase with recent progress in organ transplantation, ocular complications tend to become more diverse and serious.
  
  
  METHODS
  From 1995 to 2005, 3656 cases of organ transplantations were performed at Asan Medical Center. The medical records of 1198 of these patients who had been examined at the Department of Ophthalmology were reviewed.
  
  
  RESULTS
  Retinal complications were diagnosed in 33 of the transplant recipients; five with bone marrow transplantation, 16 with kidney transplantation, seven with liver transplantation (LT), and five with heart transplantation. Diagnoses included 11 cases of CMV (cytomegalovirus) retinitis, three of acute retinal necrosis, one of progressive outer retinal necrosis, five of fungal chorioretinitis, one of toxoplasmic retinochoroiditis, three of central retinal vein occlusion, and nine of central serous chorioretinopathy. While CMV, fungal, or toxoplasmic chorioretinitis developed frequently in association with extraocular infection or organ rejection, herpetic infection manifested only in the eye without any rejection. Most infectious cases responded well to the standard therapeutic regimen. Interestingly, central retinal vein occlusion developed exclusively following LT, possibly in relation to coagulation cascade abnormality.
  
  
  CONCLUSIONS
  To our best knowledge, this comprehensive review presents the largest series of ocular complication in organ transplant recipients. Familiarity with the potential ocular complications as well as a high index of suspicion is warranted to the practicing ophthalmologists.
authors.affiliation: Department of Ophthalmology, Asan Medical Center, University of Ulsan, College of Medicine, Seoul, Korea.
authors.forename: Hyewon
authors.initials: H
authors.lastname: Chung
authors.forename: Kyung-Hoon
authors.initials: KH
authors.lastname: Kim
authors.forename: June-Gone
authors.initials: JG
authors.lastname: Kim
authors.forename: Sun Young
authors.initials: SY
authors.lastname: Lee
authors.forename: Young Hee
authors.initials: YH
authors.lastname: Yoon
mesh_terms: D000293:Adolescent; D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects* / Q000379:methods; D002825:Chorioretinitis / Q000175:diagnosis / Q000209:etiology; D002833:Choroiditis / Q000175:diagnosis / Q000209:etiology; D017726:Cytomegalovirus Retinitis / Q000175:diagnosis / Q000209:etiology; D005260:Female; D006084:Graft Rejection / Q000517:prevention & control; D016027:Heart Transplantation / Q000009:adverse effects* / Q000379:methods; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use; D016030:Kidney Transplantation / Q000009:adverse effects* / Q000379:methods; D016031:Liver Transplantation / Q000009:adverse effects* / Q000379:methods; D008297:Male; D008875:Middle Aged; D012164:Retinal Diseases / Q000175:diagnosis / Q000209:etiology*; D015882:Retinal Necrosis Syndrome, Acute / Q000175:diagnosis / Q000209:etiology; D012170:Retinal Vein Occlusion / Q000175:diagnosis / Q000209:etiology; D012189:Retrospective Studies
chemical_list: D007166:Immunosuppressive Agents