Is there a role for proteomics in Peyronie's disease?
BACKGROUND
Peyronie's disease (PD) continues to be a major source of sexual dysfunction among the 3-9% of affected men. The challenge in treating PD is determining the natural history and clinical course for the individual patient. Currently, there exists no reliable means to predict whether a penile plaque of PD will progress, regress, or remain stable. This represents a significant deficiency in contemporary management, one that may be addressed with newer technologies such as proteomic profiling.


OBJECTIVE
This review assesses the potential use of protein alterations measured by various novel technologies, to predict progression, regression, or stabilization of PD in an affected individual.


METHODS
A comprehensive literature review of the past decade in the field of gene profiling and protein expression of PD was performed.


METHODS
A critical analysis of the existing worldwide literature evaluating surface-enhanced laser desorption/ionization time of flight mass spectrometry (SELDI-TOF-MS or SELDI) and other proteonomic techniques.


RESULTS
SELDI and other technologies can provide the clinician with innovative data indicating the presence of unique individual factors that act to suppress or promote the fibrotic process in PD. Determining the clinical implications of altered protein expression in an individual is not yet defined.


CONCLUSIONS
The area of proteomics has begun to revolutionize the study of medicine in the postgenomic era, by allowing researchers to study the role that proteins play in health and disease. Applying this knowledge clinically has already led to innovative discoveries in early cancer detection in a number of malignancies, including prostate, ovarian, and bladder. Prior to the widespread use and acceptance of proteomic technology in PD, a critical assessment of its therapeutic and diagnostic value will be required.
Domes
Trustin
T
Department of Surgery, University of Western Ontario, London, Ontario, Canada.
De Young
Ling
L
O'Gorman
David B
DB
Gan
Bing Siang
BS
Bella
Anthony J
AJ
Brock
Gerald
G
D015415:Biomarkers / Q000378:metabolism; D006801:Humans; D008297:Male; D013058:Mass Spectrometry / Q000379:methods; D008954:Models, Biological; D010411:Penile Induration / Q000175:diagnosis* / Q000235:genetics; D040081:Protein Array Analysis / Q000379:methods*; D040901:Proteomics / Q000379:methods*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
D015415:Biomarkers