Can soluble triggering receptor expressed on myeloid cells (sTREM-1) be considered an anti-inflammatory mediator in the pathogenesis of peptic ulcer disease?
Soluble triggering receptor expressed on myeloid cells (sTREM-1) is a novel mediator involved in the pathogenesis of peptic ulcer disease. To investigate the potential role of sTREM-1 in the anti-inflammatory response in chronic gastritis, sTREM-1 was compared with other anti-inflammatory mediators of gastritis. Forty patients with dyspepsia were enrolled: 20 with peptic ulcer and 20 controls without any macroscopic abnormalities. All patients were examined by endoscopy; gastric juice was aspirated and biopsy specimens were collected from the antrum and corpus of the stomach. sTREM-1, interleukin (IL)-8, and IL-10 were estimated by enzyme immunoassays. Median sTREM-1 in patient controls and in patients with peptic ulcer disease was 3.91 and 44.27 pg/ml, respectively (P=0.006). Respective values of IL-8 were 1856.97 and 2030.66 pg/ml (P=0.023); those of IL-10 were 16.92 and 18.43 pg/ml (NS). The odds ratio for the presence of peptic ulcer in the event of a concentration of sTREM-1 higher than 15 pg/ml was 23.22 (95% CI, 2.58-208.62; P=0.002). A positive correlation was found between the ratios of IL-8/sTREM-1 and IL-8/IL-10 (r (s), + 0.365; P=0.021). In conclusion, sTREM-1 is an independent factor for the generation of peptic ulcer disease and might behave as an anti-inflammatory mediator in chronic gastritis.
Koussoulas
Vassilios
V
Department of Gastroenterology, Sismanoglion General Hospital of Athens, Athens, Greece. basilkoussoulas3@hotmail.com
Tzivras
Michalis
M
Giamarellos-Bourboulis
Evangelos J
EJ
Demonakou
Maria
M
Vassilliou
Spyridon
S
Pelekanou
Aimilia
A
Papadopoulos
Antonios
A
Giamarellou
Helen
H
Barbatzas
Charalambos
C
D015415:Biomarkers / Q000378:metabolism; D001706:Biopsy; D016099:Endoscopy, Gastrointestinal; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D007150:Immunohistochemistry; D016753:Interleukin-10 / Q000378:metabolism; D016209:Interleukin-8 / Q000378:metabolism; D007413:Intestinal Mucosa / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008562:Membrane Glycoproteins / Q000096:biosynthesis*; D008875:Middle Aged; D022423:Myeloid Cells / Q000378:metabolism* / Q000473:pathology; D010437:Peptic Ulcer / Q000378:metabolism* / Q000473:pathology; D011971:Receptors, Immunologic / Q000096:biosynthesis*; D012720:Severity of Illness Index; D000073871:Triggering Receptor Expressed on Myeloid Cells-1
D015415:Biomarkers; D016209:Interleukin-8; D008562:Membrane Glycoproteins; D011971:Receptors, Immunologic; C408842:TREM1 protein, human; D000073871:Triggering Receptor Expressed on Myeloid Cells-1; D016753:Interleukin-10