WISE 2005: stroke volume changes contribute to the pressor response during ischemic handgrip exercise in women.
The mechanism of the pressor response to small muscle mass (e.g., forearm) exercise and during metaboreflex activation may include elevations in cardiac output (Q) or total peripheral resistance (TPR). Increases in Q must be supported by reductions in visceral venous volume to sustain venous return as heart rate (HR) increases. Therefore, this study tested the hypothesis that increases in Q, supported by reductions in splanchnic volume (portal vein constriction), explain the pressor response during handgrip exercise and metaboreflex activation. Seventeen healthy women performed 2 min of static ischemic handgrip exercise and 2 min of postexercise circulatory occlusion (PECO) while HR, stroke volume and superficial femoral artery flow (Doppler), blood pressure (Finometer), portal vein diameter (ultrasound imaging), and muscle sympathetic nerve activity (MSNA; microneurography) were measured followed by the calculation of Q, TPR, and leg vascular resistance (LVR). Compared with baseline, mean arterial blood pressure (MAP) (P < 0.001) and Q (P < 0.001) both increased in each minute of exercise accompanied by a approximately 5% reduction in portal vein diameter (P < 0.05). MAP remained elevated during PECO, whereas Q decreased below exercise levels. MSNA was elevated above baseline during the second minute of exercise and through the PECO period (P < 0.05). Neither TPR nor LVR was changed from baseline during exercise and PECO. The data indicate that the majority of the blood pressure response to isometric handgrip exercise in women was due to mobilization of central blood volume and elevated stroke volume and Q rather than elevations in TVR or LVR resistance.
Shoemaker
J K
JK
School of Kinesiology and Department of Physiology and Pharmacology, The University of Western Ontario, London, Ontario, Canada. kshoemak@uwo.ca
Mattar
L
L
Kerbeci
P
P
Trotter
S
S
Arbeille
P
P
Hughson
R L
RL
D000328:Adult; D001783:Blood Flow Velocity; D001794:Blood Pressure; D001810:Blood Volume; D015444:Exercise; D005260:Female; D005263:Femoral Artery / Q000000981:diagnostic imaging / Q000503:physiopathology; D005542:Forearm; D018737:Hand Strength; D006339:Heart Rate; D006801:Humans; D007511:Ischemia / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology*; D007537:Isometric Contraction; D018763:Muscle Fatigue; D018482:Muscle, Skeletal / Q000098:blood supply / Q000294:innervation / Q000378:metabolism / Q000503:physiopathology*; D011169:Portal Vein / Q000000981:diagnostic imaging / Q000503:physiopathology; D012018:Reflex; D013026:Space Flight; D013152:Splanchnic Circulation; D013318:Stroke Volume; D016683:Supine Position; D013564:Sympathetic Nervous System / Q000503:physiopathology; D013997:Time Factors; D014463:Ultrasonography; D014655:Vascular Resistance