title: Kidney transplantation at the Chinese People's Liberation Army General Hospital.
abstract: Between October 1977 and December 2004, 2,037 kidney transplants were performed in 1,804 patients with ESRD at the Peoples Liberation Army General Hospital Postgraduate Medical School. Overall graft survival rates at one, 5, 10, 15, and 20 years were 91.6%, 79.3%, 64.3%, 53.8%, and 47.6%, respectively. The number of transplants significantly increased during the past decade. One-year patient and graft survival rates have increased from 40% and 35% in the 1970s to 98% and 96% in the 2000s, respectively. Since CSA was introduced to our clinic, one-year graft survival rates have increased from 33% to 93% and the half-lives have significantly improved from 13.1 years to 21.7 years. Also, the graft survival rate for patients on CSA-based triple therapy using MMF was about 18% higher at 5 years than those for patients using AZA (92% vs. 74%, p < 0.001), and 11% higher at 10 years (71% vs. 60%, p < 0.01). Our analysis showed that transplant year, DGF, rejection, immunosuppressive regimen, ABO blood group, and original disease were independent factors impacting on graft survival and poor HLA matching with 5-6 mismatches had an adverse effect on graft survival compared with 1-2 mismatches. Infection, cardio- and cerebral accidents and hepatic failure were the 3 main causes of death in transplant recipients.
authors.affiliation: Department of Urology, Chinese People's Liberation Army General Hospital, Postgraduate Medical School, Beijing, China.
authors.forename: Xuren
authors.initials: X
authors.lastname: Xiao
authors.forename: Jianhua
authors.initials: J
authors.lastname: Ao
authors.forename: Jinshan
authors.initials: J
authors.lastname: Lu
authors.forename: Baofa
authors.initials: B
authors.lastname: Hong
authors.forename: Linyang
authors.initials: L
authors.lastname: Ye
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.forename: Cai
authors.initials: C
authors.lastname: Wei
authors.forename: Jiangping
authors.initials: J
authors.lastname: Gao
authors.forename: Yong
authors.initials: Y
authors.lastname: Yang
authors.forename: Jun
authors.initials: J
authors.lastname: Dong
authors.forename: Xiaoxiong
authors.initials: X
authors.lastname: Wang
authors.forename: Yantang
authors.initials: Y
authors.lastname: Li
authors.forename: Dianyi
authors.initials: D
authors.lastname: Xu
mesh_terms: D000328:Adult; D002681:China; D005260:Female; D005500:Follow-Up Studies; D006085:Graft Survival; D006650:Histocompatibility Testing; D006772:Hospitals, Military / Q000706:statistics & numerical data*; D006801:Humans; D016030:Kidney Transplantation / Q000401:mortality / Q000502:physiology / Q000706:statistics & numerical data*; D008297:Male; D008875:Middle Aged; D018579:Patient Selection; D012189:Retrospective Studies; D016019:Survival Analysis; D014019:Tissue Donors / Q000706:statistics & numerical data; D016896:Treatment Outcome