Incidence of neonatal herpes simplex virus infections in a managed-care population.
OBJECTIVE
To determine the incidence of possible neonatal herpes simplex virus (HSV) infections, HSV infection status of women with infected infants, and use of measures to reduce risk of HSV transmission to the neonate in a large US managed-care population.


METHODS
Retrospective analysis of administrative claims from the Integrated Health Care Information Services National Managed Care Benchmark database.


RESULTS
Of 233,487 infants born to 252,474 mothers from January 1997 to June 2002, the numbers assigned an ICD-9 code reflecting possible neonatal HSV infection </=30 and </=90 days of birth were 178 (0.08%) and 338 (0.15%), respectively. Of the 338 mothers delivering infants with possible neonatal HSV </=90 days postnatally, 12% had a prior HSV diagnosis, 5% were prescribed an antiviral medication during the study period, and 3% used antiviral medication and had a cesarean delivery.


CONCLUSIONS
These results support national surveillance of neonatal HSV to better define its incidence, strengthen health policies, and improve prevention and treatment.
Whitley
Richard
R
Department of Pediatrics, Microbiology, Medicine and Neurosurgery, University of Alabama at Birmingham, Birmingham, Alabama, USA. rwhitley@peds.uab.edu
Davis
Elizabeth Anne
EA
Suppapanya
Nittaya
N
D003953:Diagnosis-Related Groups / Q000706:statistics & numerical data; D005260:Female; D006561:Herpes Simplex / Q000453:epidemiology* / Q000209:etiology / Q000517:prevention & control* / Q000635:transmission; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical / Q000706:statistics & numerical data*; D008297:Male; D008329:Managed Care Programs; D008499:Medical Records; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000453:epidemiology* / Q000209:etiology / Q000517:prevention & control*; D011295:Prenatal Care; D012189:Retrospective Studies; D014481:United States / Q000453:epidemiology