title: In vitro activities of CG400549, a novel FabI inhibitor, against recently isolated clinical staphylococcal strains in Korea.
abstract: The in vitro activities of CG400549, a novel FabI inhibitor, were compared to those of linezolid and commonly used antimicrobials against recent bacterial isolates. CG400549 had an MIC(90) of 0.5 microg/ml for Staphylococcus aureus strains and was more potent than either linezolid or vancomycin.
authors.affiliation: Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Jong Hwa
authors.initials: JH
authors.lastname: Yum
authors.forename: Chang Ki
authors.initials: CK
authors.lastname: Kim
authors.forename: Dongeun
authors.initials: D
authors.lastname: Yong
authors.forename: Kyungwon
authors.initials: K
authors.lastname: Lee
authors.forename: Yunsop
authors.initials: Y
authors.lastname: Chong
authors.forename: Cheol Min
authors.initials: CM
authors.lastname: Kim
authors.forename: Jeong Mi
authors.initials: JM
authors.lastname: Kim
authors.forename: Seonggu
authors.initials: S
authors.lastname: Ro
authors.forename: Joong Myung
authors.initials: JM
authors.lastname: Cho
mesh_terms: D000081:Acetamides / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000494:pharmacology; D050753:Enoyl-(Acyl-Carrier-Protein) Reductase (NADH) / Q000037:antagonists & inhibitors* / Q000737:chemistry; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D007723:Korea / Q000453:epidemiology; D000069349:Linezolid; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D023303:Oxazolidinones / Q000494:pharmacology; D011725:Pyridines / Q000009:adverse effects / Q000494:pharmacology; D013210:Staphylococcus / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics / Q000254:growth & development / Q000302:isolation & purification*; D013211:Staphylococcus aureus / Q000187:drug effects*; D058924:Thienopyridines; D013876:Thiophenes / Q000009:adverse effects / Q000494:pharmacology
chemical_list: D000081:Acetamides; D000890:Anti-Infective Agents; C523750:CG 400549; D004791:Enzyme Inhibitors; D023303:Oxazolidinones; D011725:Pyridines; D058924:Thienopyridines; D013876:Thiophenes; D050753:Enoyl-(Acyl-Carrier-Protein) Reductase (NADH); D000069349:Linezolid