[Iron overload and arthropathy].
Arthropathy is a major and distinctive manifestation of hemochromatosis, resembling degenerative joint disease with involvement of unusual articular sites, almost identical to the arthropathy in calcium pyrophosphate dihydrate crystals deposition disease (chondrocalcinosis), associated with osteoporosis. Hemochromatosis is the clinical condition of iron overload; it can be genetic or secondary. It is important to know how to diagnose early genetic hemochromatosis since it is a frequent, life-threatening and treatable condition. Early bio-clinical symptoms are weakness, arthralgias and increase of serum tranferrin saturation.
Chalès
Gérard
G
Service de rhumatologie, hôpital Sud, 35203 Rennes Cedex 2. gerard.chales@chu-rennes.fr
Guggenbuhl
Pascal
P
Pawlotsky
Yves
Y
D000328:Adult; D000367:Age Factors; D001851:Bone Diseases, Metabolic / Q000175:diagnosis; D002805:Chondrocalcinosis / Q000000981:diagnostic imaging; D003937:Diagnosis, Differential; D005260:Female; D006432:Hemochromatosis / Q000097:blood / Q000150:complications* / Q000175:diagnosis / Q000209:etiology / Q000235:genetics; D006801:Humans; D007592:Joint Diseases / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000209:etiology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000209:etiology; D010024:Osteoporosis / Q000175:diagnosis; D011859:Radiography; D014168:Transferrin / Q000032:analysis
D014168:Transferrin