Synthetic studies on macrolactin A: construction of C4-C24 fragment.
The preparation of the C4-C24 fragment of the macrolactin A is described. The adopted synthetic strategy involves two isomerizations to selectively construct the (8E,10Z) and (16E,18E) dienes, using a sequential Claisen rearrangement/allene isomerization and a Ph3P-catalyzed isomerization of an yne-one, respectively.
Georgy
Marie
M
ICSN-CNRS Avenue de la Terrasse, 91198 Gif-sur-Yvette, France.
Lesot
Philippe
P
Campagne
Jean-Marc
JM
D002625:Chemistry, Organic / Q000379:methods*; D007536:Isomerism; D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure
D018942:Macrolides; C453562:macrolactin A