title: Modulating effect of Hypericum perforatum extract on astrocytes in MPTP induced Parkinson's disease in mice.
abstract: The present study has been evaluated the neuroprotective effect of Hypericum perforatum extract on the reaction of astrocytes in mice brain treated with an intraperitoneal injection of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) (20 mg/kg with 2 hr intervals). Treatment with Hypericum perforatum extract (HPE) resulted in an inhibition of monoamine oxidase-B (MAO-B) activity and reduced astrocyte activation in striatal area induced by MPTP. The results show that HPE has neuromodulating effect against MPTP induced Parkinson's disease in mice.
authors.affiliation: Department of Zoology, Annamalai University, Annamalainagar 608 002, Tamilnadu, India.
authors.forename: M
authors.initials: M
authors.lastname: Mohanasundari
authors.forename: M
authors.initials: M
authors.lastname: Sabesan
mesh_terms: D000818:Animals; D001253:Astrocytes / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D003342:Corpus Striatum / Q000737:chemistry / Q000187:drug effects / Q000201:enzymology; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D020902:Hypericum / Q000737:chemistry*; D007150:Immunohistochemistry; D020267:MPTP Poisoning / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D008297:Male; D051379:Mice; D008995:Monoamine Oxidase / Q000378:metabolism; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D005904:Glial Fibrillary Acidic Protein; D010936:Plant Extracts; D008995:Monoamine Oxidase