Repeated administration of diphenyl ditelluride induces hematological disorders in rats.
In the present study, we investigated potential toxic effects of diphenyl ditelluride, as measured by biochemical and hematological parameters. Rats were given a daily dose of 0.3 micromol/kg diphenyl ditelluride by subcutaneous route and sacrificed at different times (24 and 48 h). Hepatic and renal TBARS levels were changed by diphenyl ditelluride exposure at the dose 0.9 micromol/Kg in rats. Diphenyl ditelluride exposure demonstrated an increase in AST (aspartate aminotransferase), ALT (alanine aminotransferase) and LDH (lactate dehydrogenase) activities. Plasma creatinine and urea levels increase after diphenyl ditelluride exposure. Diphenyl ditelluride also produced a significant decrease in plasma triglyceride and cholesterol levels. In contrast, this compound, at all doses tested, induced a marked increase in total leukocyte counts. The present study suggests that diphenyl ditelluride induces hematological disorders and provides evidence for renal and hepatic toxicity in rats.
Borges
V C
VC
Departamento de Quimica, Centro de Ciencias Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, CEP 97105-900, RS, Brazil.
Rocha
J B T
JB
Savegnago
L
L
Nogueira
C W
CW
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001555:Benzene Derivatives / Q000633:toxicity*; D001835:Body Weight / Q000187:drug effects; D001853:Bone Marrow / Q000473:pathology; D002097:C-Reactive Protein / Q000378:metabolism; D056486:Chemical and Drug Induced Liver Injury; D002784:Cholesterol / Q000097:blood; D003401:Creatine / Q000097:blood; D004435:Eating / Q000187:drug effects; D006651:Histocytochemistry; D007674:Kidney Diseases / Q000097:blood / Q000139:chemically induced* / Q000473:pathology; D007770:L-Lactate Dehydrogenase / Q000097:blood; D007958:Leukocyte Count; D008107:Liver Diseases / Q000097:blood / Q000473:pathology; D008297:Male; D009942:Organometallic Compounds / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D014280:Triglycerides / Q000097:blood; D014508:Urea / Q000097:blood
D001555:Benzene Derivatives; D009942:Organometallic Compounds; D017392:Thiobarbituric Acid Reactive Substances; D014280:Triglycerides; C434247:diphenylditelluride; D014508:Urea; D002097:C-Reactive Protein; D002784:Cholesterol; D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D003401:Creatine