title: Study on glycosylated prodrugs of toxoflavins for antibody-directed enzyme tumor therapy.
abstract: Eight novel toxoflavin glycosides, which are potential prodrugs in antibody directed enzyme prodrug therapy (ADEPT), were synthesized. The structures of all toxoflavin glycosides were characterized by (13)C NMR spectroscopy, elemental analysis, and MS. Their enzymatic hydrolysis activities were tested against beta-glucosidase (EC.3.2.1.21).
authors.affiliation: School of Life Sciences, Northeast Normal University, Changchun 130024, PR China.
authors.forename: Shusheng
authors.initials: S
authors.lastname: Wang
authors.forename: Dan
authors.initials: D
authors.lastname: Liu
authors.forename: Xu
authors.initials: X
authors.lastname: Zhang
authors.forename: Shengyu
authors.initials: S
authors.lastname: Li
authors.forename: Yongxu
authors.initials: Y
authors.lastname: Sun
authors.forename: Jia
authors.initials: J
authors.lastname: Li
authors.forename: Yifa
authors.initials: Y
authors.lastname: Zhou
authors.forename: Liping
authors.initials: L
authors.lastname: Zhang
mesh_terms: D000906:Antibodies / Q000276:immunology*; D006027:Glycosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D007167:Immunotherapy / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy; D009369:Neoplasms / Q000628:therapy; D011355:Prodrugs / Q000737:chemistry* / Q000627:therapeutic use; D011744:Pyrimidinones / Q000737:chemistry* / Q000627:therapeutic use; D014227:Triazines / Q000737:chemistry* / Q000627:therapeutic use; D001616:beta-Galactosidase / Q000737:chemistry / Q000378:metabolism
chemical_list: D000906:Antibodies; D006027:Glycosides; D011355:Prodrugs; D011744:Pyrimidinones; D014227:Triazines; C009570:toxoflavin; D001616:beta-Galactosidase