[Research advance of role of inhibitor of differentiation 2 in skeletal muscle regeneration].
OBJECTIVE
To review researches of the role of inhibitor of differentiation 2(Id2) in skeletal muscle regeneration.


METHODS
The latest original literature concerning Id2 and its role in skeletal muscle regeneration was extensively reviewed.


RESULTS
Id2 could form heterodimers by combining with E protein to prevent myogenic regulatory factors (MRFs) forming heterodimers by combining with E protein, to inhibit the transcription activity of MRFs and differentiation of skeletal muscle cell.


CONCLUSIONS
Id2 plays an important role in skeletal muscle regeneration.
Lai
Guihua
G
Department of Anatomy, Southern Medical University, Guangdong Provincial Key Laboratory of Tissue Construction and Inspection, Guangzhou Guangdong, 510515, PR China. lai7890@sohu.com
Qiu
Xiaozhong
X
Ouyang
Jun
J
D000818:Animals; D002454:Cell Differentiation; D049109:Cell Proliferation; D006801:Humans; D051797:Inhibitor of Differentiation Protein 2 / Q000502:physiology*; D051379:Mice; D018482:Muscle, Skeletal / Q000166:cytology / Q000293:injuries / Q000502:physiology*; D032446:Myoblasts / Q000166:cytology / Q000502:physiology; D018006:Myogenic Regulatory Factors / Q000037:antagonists & inhibitors*; D012038:Regeneration
D051797:Inhibitor of Differentiation Protein 2; D018006:Myogenic Regulatory Factors