title: The release of systemic inflammatory mediators is independent of cardiopulmonary bypass temperature.
abstract: OBJECTIVE
  The aim of this study was to investigate the effect of systemic CPB temperature on the production of the key mediators of the systemic inflammatory response to coronary artery bypass graft (CABG) surgery.
  
  
  METHODS
  Randomized clinical study.
  
  
  METHODS
  University hospital.
  
  
  METHODS
  Thirty patients undergoing first-time CABG surgery.
  
  
  METHODS
  The patients were randomized to hypothermic (32 degrees C, n = 15) or normothermic (36 degrees C, n = 15) CPB.
  
  
  RESULTS
  Plasma interleukin (IL)-6, IL-8, IL-10, C-reactive protein (CRP), cortisol, and neutrophils were measured the day before operation, at closure of the sternum, and 4, 16, and 44 hours later. The cytokine, CRP, cortisol, and neutrophil responses were independent of temperature during CPB with peak concentrations of IL-10 at closure of the sternum followed by IL-6, IL-8, cortisol, neutrophils, and finally CRP. A correlation between maximal plasma concentrations of IL-10 and cortisol was seen in both groups after surgery (p = 0.02). Drainage after surgery was lower after normothermic CPB (p=0.02), with no difference in the requirement for blood transfusion. All patients were discharged from the intensive care unit within 24 hours after surgery.
  
  
  CONCLUSIONS
  The release of systemic inflammatory mediators after cardiac surgery was independent of mild hypothermia (32 degrees C) versus normothermia (36 degrees C) during CPB.
authors.affiliation: Department of Cardiothoracic Anaesthesia and Intensive Care Medicine, Center for Cardiovascular Research, Aalborg Hospital, Aarhus University, Aalborg, Denmark. an.bsr@nja.dk
authors.forename: Bodil S
authors.initials: BS
authors.lastname: Rasmussen
authors.forename: Jørn
authors.initials: J
authors.lastname: Sollid
authors.forename: Lise
authors.initials: L
authors.lastname: Knudsen
authors.forename: Trine
authors.initials: T
authors.lastname: Christensen
authors.forename: Egon
authors.initials: E
authors.lastname: Toft
authors.forename: Else
authors.initials: E
authors.lastname: Tønnesen
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D001831:Body Temperature; D002097:C-Reactive Protein / Q000378:metabolism; D002315:Cardiopulmonary Bypass; D001026:Coronary Artery Bypass; D003324:Coronary Artery Disease / Q000097:blood / Q000601:surgery; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007036:Hypothermia, Induced; D018836:Inflammation Mediators / Q000097:blood*; D016753:Interleukin-10 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D016209:Interleukin-8 / Q000097:blood; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000378:metabolism; D012107:Research Design; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D018836:Inflammation Mediators; D015850:Interleukin-6; D016209:Interleukin-8; D016753:Interleukin-10; D002097:C-Reactive Protein; D006854:Hydrocortisone