title: Back to the future of oridonin: again, compound from medicinal herb shows potent antileukemia efficacies in vitro and in vivo.
authors.affiliation: State Key Laboratory of Medical Genomics and Shanghai Institute of Hematology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 197 Ruijin Road II, Shanghai 200025, China.
authors.forename: Guang-Biao
authors.initials: GB
authors.lastname: Zhou
authors.forename: Sai-Juan
authors.initials: SJ
authors.lastname: Chen
authors.forename: Zhen-Yi
authors.initials: ZY
authors.lastname: Wang
authors.forename: Zhu
authors.initials: Z
authors.lastname: Chen
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D002453:Cell Cycle / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D050676:Core Binding Factor Alpha 2 Subunit / Q000235:genetics / Q000378:metabolism; D004224:Diterpenes / Q000494:pharmacology*; D045786:Diterpenes, Kaurane / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology; D006801:Humans; D037602:Isodon / Q000737:chemistry*; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy*; D053078:Membrane Potential, Mitochondrial / Q000187:drug effects; D015514:Oncogene Proteins, Fusion / Q000235:genetics / Q000378:metabolism; D000075142:RUNX1 Translocation Partner 1 Protein; D014407:Tumor Cells, Cultured
chemical_list: C107844:AML1-ETO fusion protein, human; D000972:Antineoplastic Agents, Phytogenic; D050676:Core Binding Factor Alpha 2 Subunit; D004224:Diterpenes; D045786:Diterpenes, Kaurane; D004365:Drugs, Chinese Herbal; D015514:Oncogene Proteins, Fusion; D000075142:RUNX1 Translocation Partner 1 Protein; C011959:oridonin