title: Design of simulated moving bed processes under reduced purity requirements.
abstract: The design of simulated moving bed chromatography under reduced purity requirements is investigated. A parametric study indicates that all internal flow rates should be considered as free parameters in process design. This is confirmed by systematic numerical optimisations of two different design scenarios. A restrictive scenario requires complete regeneration of liquid and solid phases. In contrast, in a non-restrictive design all flow rates are optimised. The latter leads to significantly improved process performance. On the basis of the obtained observations, a simple design method for simulated moving bed processes with desired outlet purity values is derived from equilibrium theory.
authors.affiliation: Max-Planck-Institut für Dynamik komplexer technischer Systeme, D-39106 Magdeburg, Germany. kaspereit@mpi-magdeburg.mpg.de
authors.forename: Malte
authors.initials: M
authors.lastname: Kaspereit
authors.forename: Andreas
authors.initials: A
authors.lastname: Seidel-Morgenstern
authors.forename: Achim
authors.initials: A
authors.lastname: Kienle
mesh_terms: D000327:Adsorption; D000465:Algorithms; D005591:Chemical Fractionation; D002850:Chromatography, Gel / Q000379:methods*; D002853:Chromatography, Liquid / Q000295:instrumentation* / Q000379:methods*; D003198:Computer Simulation; D004867:Equipment Design; D008956:Models, Chemical; D012997:Solvents / Q000737:chemistry*; D013678:Technology, Pharmaceutical / Q000295:instrumentation*; D013816:Thermodynamics
chemical_list: D012997:Solvents