title: Glycosylation of capsaicin and 8-nordihydrocapsaicin by cultured cells of Catharanthus roseus.
abstract: The glycosylation of capsaicin and 8-nordihydrocapsaicin was investigated using cultured cells of Catharanthus roseus. In addition to capsaicin 4-O-beta-d-glucopyranoside (170 microg/g fr. wt of cells), the biotransformation products, capsaicin 4-O-(6-O-beta-D-xylopyranosyl)-beta-D-glucopyranoside (116 microg/g fr. wt of cells) and capsaicin 4-O-(6-O-alpha-L-arabinopyranosyl)-beta-D-glucopyranoside (83 microg/g fr. wt of cells), were isolated from the cell suspension after three days of incubation with capsaicin. Two other compounds, 8-nordihydrocapsaicin 4-O-(6-O-beta-D-xylopyranosyl)-beta-D-glucopyranoside (171 microg/g fr. wt of cells) and 8-nordihydrocapsaicin 4-O-(6-O-alpha-L-arabinopyranosyl)-beta-D-glucopyranoside (122 microg/g fr. wt of cells), together with the known 8-nordihydrocapsaicin 4-O-beta-D-glucopyranoside (204 microg/g fr. wt of cells) were also isolated from the cell suspension after incubation with 8-nordihydrocapsaicin.
authors: Department of Pharmacology and Therapeutics, Faculty of Medicine, Oita University, 1-1 Hasama-machi, Oita 879-5593, Japan.
authors: Kei
authors: K
authors: Shimoda
authors: Soonil
authors: S
authors: Kwon
authors: Akiko
authors: A
authors: Utsuki
authors: Shingo
authors: S
authors: Ohiwa
authors: Hisashi
authors: H
authors: Katsuragi
authors: Naoko
authors: N
authors: Yonemoto
authors: Hatsuyuki
authors: H
authors: Hamada
authors: Hiroki
authors: H
authors: Hamada
mesh_terms: D001711:Biotransformation; D002211:Capsaicin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism*; D030008:Catharanthus / Q000378:metabolism*; D002478:Cells, Cultured; D006031:Glycosylation
chemical_list: C517386:nordihydrocapsaicin; D002211:Capsaicin