[Good clinical practices and inpatient antibiotics: optimization of fluoroquinolone switch therapy].
OBJECTIVE
Intravenous-to-oral switch therapy is strongly recommended in the medical literature. The aim of this study was to assess how we can improve fluoroquinolone switch therapy.


METHODS
In this comparative prospective study, we analyzed 243 intravenous ciprofloxacin treatments and assessed the impact of promoting a switch to oral step-down therapy.


RESULTS
This study found that switches from intravenous to oral therapy increased, mainly in medical wards, and led to significant savings in direct costs.


CONCLUSIONS
Promoting switch therapy has improved clinical practices in antibiotic use and led to lower direct and probably indirect drug-related costs.


CONCLUSIONS
Our findings will help define the role of switch therapy in improving clinical practices in inpatient antibiotic use.
Rigaud
Baptiste
B
Service Pharmacie, CHU, Dijon. baptiste.rigaud@chu-limoges.fr
Malbranche
Charlotte
C
Pioud
Virginie
V
Lochard
Audrey
A
Chemelle
Mathilde
M
Aube
Hervé
H
Lazzarotti
Aline
A
Guignard
Marie-Hélène
MH
D000284:Administration, Oral; D000890:Anti-Infective Agents / Q000008:administration & dosage* / Q000191:economics*; D016009:Chi-Square Distribution; D002939:Ciprofloxacin / Q000008:administration & dosage* / Q000191:economics*; D017046:Cost Savings; D003627:Data Interpretation, Statistical; D016527:Drug Costs; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D007297:Inpatients; D008297:Male; D010818:Practice Patterns, Physicians'; D011446:Prospective Studies
D000890:Anti-Infective Agents; D002939:Ciprofloxacin