title: Primary chondroid melanoma of the nasal skin: a rare melanoma variant at a previously undocumented site.
abstract: Heterologous differentiation is exceedingly rare in melanoma. Only four cases of melanoma demonstrating exclusive cartilaginous differentiation have been documented, all having occurred on the lower extremity. We report a chondroid melanoma involving the nasal skin and presenting clinically as a basal cell carcinoma. Both Melan-A and microphthalmia transcription factor protein immunoperoxidase stains were positive in our case, demonstrating the potential utility of these two stains in chondroid melanoma. We also provide a succinct review of the literature on this rare melanoma variant.
authors: Ampath Pathology Laboratories, Pretoria, South Africa. slavikt@ampath.co.za
authors: Tomas
authors: T
authors: Slavik
authors: Marius
authors: M
authors: Hannah
authors: Ralph A
authors: RA
authors: Schroder
mesh_terms: D002280:Basal Cell Carcinoma / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008545:Melanoma / Q000378:metabolism / Q000473:pathology*; D008875:Middle Aged; D009666:Nose / Q000473:pathology*; D012878:Skin Neoplasms / Q000378:metabolism / Q000473:pathology*