title: Aspergillus infection of implantable cardioverter-defibrillators and pacemakers: case report and literature review.
abstract: Presented here is a case of implantable-cardioverter-defibrillator infection caused by Aspergillus flavus and a review of 14 previously reported Aspergillus infections of pacemakers or implantable cardioverter-defibrillators. Among all 15 cases, fever was the most common presenting feature (11 patients). Three patients presented with generator-pocket inflammation. Transthoracic echocardiography was performed on eight of 13 patients with endocarditis, revealing vegetations in only one. Transesophageal echocardiography demonstrated the presence of vegetations in all eight of the patients on whom it was performed (p < 0.01). Death was due to the Aspergillus infection in five cases. Patients who presented with unexplained fever had a higher mortality rate (60%) than patients with other clinical presentations (20%, p = 0.166).
authors: Department of Cardiology, Hospital Universitario Puerta de Hierro, Universidad Autónoma de Madrid, San Martin de Porres no. 4, 28050, Madrid, Spain.
authors: M
authors: M
authors: Cobo
authors: A
authors: A
authors: Ramos
authors: J
authors: J
authors: Toquero
authors: E
authors: E
authors: Muñez
authors: T
authors: T
authors: Alvárez-Espejo
authors: M
authors: M
authors: Muñoz
authors: I
authors: I
authors: Fernández
mesh_terms: D000368:Aged; D000935:Antifungal Agents / Q000627:therapeutic use; D001231:Aspergillus flavus / Q000187:drug effects / Q000472:pathogenicity*; D017147:Defibrillators, Implantable / Q000382:microbiology*; D005260:Female; D006801:Humans; D009181:Mycoses / Q000188:drug therapy / Q000382:microbiology*; D016459:Prosthesis-Related Infections / Q000188:drug therapy / Q000382:microbiology*; D011743:Pyrimidines / Q000627:therapeutic use; D014230:Triazoles / Q000627:therapeutic use; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole