Lack of differences of motorcortical excitability in the morning as compared to the evening in juvenile myoclonic epilepsy--a study using transcranial magnetic stimulation.
We used transcranial magnetic stimulation (TMS) in patients with juvenile myoclonic epilepsy (JME) and healthy controls to characterise motorcortical excitability in the morning as compared to the evening. Intra- and interindividual comparisons in JME-patients and controls showed no significant differences of any TMS parameter. The expected rise of the resting motor thresholds (RMT) in JME-patients taking anticonvulsants could not be detected which may indicate a decreased RMT in JME-patients.
Pfütze
Martin
M
Interdisciplinary Epilepsy Center, Department of Neurology, Philipps-University Marburg, Marburg, Germany. pfuetze@med.uni-marburg.de
Reis
Janine
J
Haag
Anja
A
John
Daniel
D
Hattemer
Katja
K
Oertel
Wolfgang H
WH
Rosenow
Felix
F
Hamer
Hajo M
HM
D000293:Adolescent; D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use; D002940:Circadian Rhythm / Q000502:physiology*; D004569:Electroencephalography; D004832:Epilepsy, Absence / Q000503:physiopathology; D004830:Epilepsy, Tonic-Clonic / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D009044:Motor Cortex / Q000503:physiopathology*; D020190:Myoclonic Epilepsy, Juvenile / Q000503:physiopathology*; D050781:Transcranial Magnetic Stimulation
D000927:Anticonvulsants