[Wound healing in venous ulcers; mechanisms, approach and modern developments].
A large proportion of the population, particularly the elderly, suffer from venous insufficiency which regularly leads to the development of leg ulcers. Delayed wound healing is a major problem in ulcers making them a target for both conventional and newly developed advanced therapies. Good compression therapy and wound cleansing are essential for wound healing. A number of advanced local application therapies are currently being developed that are aimed particularly at the 'hard-to-heal' group. These therapies include the application of tissue-engineered skin substitutes.
Gibbs
S
S
VU Medisch Centrum, afd. Dermatologie, Postbus 7057, 1007 MB Amsterdam. s.gibbs@vumc.nl
van den Hoogenband
H M
HM
de Boer
E M
EM
D003094:Collagen / Q000627:therapeutic use*; D006801:Humans; D017768:Skin, Artificial; D016896:Treatment Outcome; D014647:Varicose Ulcer / Q000628:therapy*; D014945:Wound Healing / Q000502:physiology
C117898:Apligraf; D003094:Collagen