Functionalized nano-magnetic particles for an in vivo delivery system.
Nanotechnologies to allow the nondisruptive introduction of carriers in vivo have wide potential for therapeutic delivery system. We have prepared functional nano-magnetic particles (d = 3 nm) by silanization with (3-aminopropyl) triethoxysilane. For the purpose of functionalizing the surface of the nanoparticles with amino groups for subsequent cross-linking with pharmaceuticals and biomolecules. The extremely small particles were successfully introduced into living cells without any further modification to enhance endocytic internalization, such as the use of a cationic help. The cells containing the internalized particles continued to thrive, indicating that the particles have no inhibition effect for mitosis. In addition, the particles could be incorporated into the subcutaneous tissue of mouse's ear from ear skin and were able to be localized upon application of an external magnetic field. The functionalized nano-magnetic particles are expected to be useful as a new delivery tool.
Moritake
Shinji
S
Mitsubishi Kagaku Institute of Life Sciences, 11 Minamiooya, Machida City, Tokyo 194-8511, Japan.
Taira
Shu
S
Ichiyanagi
Yuko
Y
Morone
Nobuhiro
N
Song
Si-Young
SY
Hatanaka
Takahiro
T
Yuasa
Shigeki
S
Setou
Mitsutoshi
M
D000818:Animals; D002460:Cell Line; D016503:Drug Delivery Systems; D008280:Magnetics; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D051379:Mice; D008854:Microscopy, Electron; D053769:Nanocapsules / Q000737:chemistry* / Q000648:ultrastructure*; D036103:Nanotechnology; D010316:Particle Size; D012867:Skin / Q000378:metabolism
D053769:Nanocapsules