title: Drug-supported microparticles of calcium carbonate nanocrystals and its covering with hydroxyapatite.
abstract: Drug-supported spherical microparticles with below 3 microm in diameter of calcium carbonate (CC) nanocrystals were precipitated by a complex decomposition method from Na2CO3 and CaCl2 solutions with hydrocortisone phosphate (HyC). The HyC was completely incorporated into the microparticles and was adsorbed on the surface of nanocrystals. The crystal phases of vaterite and calcite were controlled by the addition of magnesium ions. Spherical microparticles of calcite cores and petal-shaped hydroxyapatite (HAp) outer layers were fabricated by soaking calcite into the SBF, or a supersaturated solution of phosphate ions to enhance the crystal growth of HAp.
authors: National Institute for Materials Science, Biomaterials Center, Namiki 1-1, Tsukuba, Ibaraki 305-0044, Japan.
authors: Toshiyuki
authors: T
authors: Ikoma
authors: Toru
authors: T
authors: Tonegawa
authors: Hajime
authors: H
authors: Watanaba
authors: Guoping
authors: G
authors: Chen
authors: Junzo
authors: J
authors: Tanaka
authors: Yutaka
authors: Y
authors: Mizushima
mesh_terms: D002119:Calcium Carbonate / Q000737:chemistry*; D016503:Drug Delivery Systems; D017886:Durapatite / Q000737:chemistry*; D006854:Hydrocortisone / Q000008:administration & dosage; D008854:Microscopy, Electron; D008855:Microscopy, Electron, Scanning; D053758:Nanoparticles / Q000737:chemistry / Q000648:ultrastructure; D036103:Nanotechnology; D010316:Particle Size; D017550:Spectroscopy, Fourier Transform Infrared; D014961:X-Ray Diffraction
chemical_list: D017886:Durapatite; D002119:Calcium Carbonate; D006854:Hydrocortisone