title: [Oxidative stress and immune response in eumenorrheic underweight patients].
abstract: Malnutrition is known to induce a state of immunodeficiency and a predisposition to death from infectious diseases. During fasting or starvation, it appears that oxidative stress is decreased. The goal of our study was to assess the interrelation between nutritional factors, oxidative stress and immune response. The malondialdehyde (MDA)-marker of lipid peroxidation, white blood cell count, differential count and hormonal status (FSH, LH, and cortisol) were followed in eumenorrheic underweight patients. MDA was significantly lower and lymphocyte count was significantly increased in eumenorrheic underweight patients as compared to normal weight patients. Gonadal and adrenal axes were found normal in eumenorrheic underweight patients. Body mass index was positively correlated with MDA and negatively correlated with lymphocyte count. Low levels of lipid peroxidation and non-suppressed immune function in underweight patients may be explained by an increased sensitivity to leptin but further studies are requested.
authors: Facultatea de Medicina, Disciplina de Fiziopatologie, Universitatea de Medicina şi Farmacie "Gr.T. Popa", Iaşi.
authors: Veronica
authors: V
authors: Mocanu
authors: Silvia
authors: S
authors: Mandaşescu
authors: Ana-Maria
authors: AM
authors: Dascaliţa
authors: Didona
authors: D
authors: Ungureanu
authors: Anca Roxana
authors: AR
authors: Costan
authors: Veronica
authors: V
authors: Luca
authors: E
authors: E
authors: Zbranca
mesh_terms: D000328:Adult; D015992:Body Mass Index; D001835:Body Weight; D005260:Female; D006801:Humans; D018655:Lymphocyte Count; D044342:Malnutrition / Q000097:blood / Q000276:immunology*; D008315:Malondialdehyde / Q000097:blood; D008597:Menstrual Cycle; D018384:Oxidative Stress / Q000276:immunology*
chemical_list: D008315:Malondialdehyde