title: Evaluation of modified CMC and CMC-PVA as miscible polymer blend membranes for hepatocytes.
abstract: CMC and CMC-PVA were blended either with type I collagen, BSA or CS to obtain biocompatible membranes for evaluation as potential hepatocyte culture substrates. Pure and modified forms of CMC showed distinct surface, mechanical, and cell attachment properties. While the hydrophilicity decreased, the mechanical stability and the porosity of CMC membranes increased after blending. Serum proteins were adsorbed by all types of membranes. Among eight membranes tested, collagen-modified CMC was found to be a suitable membrane material for hepatocyte culture, in terms of mechanical and cell interaction properties.
authors: Ankara University, Faculty of Science and Biotechnology Institute, Tissue Engineering and Biomaterials Laboratory, Ankara 06100, Turkey.
authors: Aysel
authors: A
authors: Koç
authors: Serap
authors: S
authors: Durkut
authors: A Eser
authors: AE
authors: Elçin
authors: Erdal
authors: E
authors: Tan
authors: Y Murat
authors: YM
authors: Elçin
mesh_terms: D000818:Animals; D002266:Carboxymethylcellulose Sodium / Q000737:chemistry*; D018929:Cell Culture Techniques; D002470:Cell Survival; D002478:Cells, Cultured; D022781:Hepatocytes / Q000166:cytology* / Q000201:enzymology; D019164:Liver, Artificial; D008297:Male; D008422:Materials Testing; D018625:Microscopy, Atomic Force; D011142:Polyvinyl Alcohol / Q000737:chemistry*; D051381:Rats; D044967:Serum; D017550:Spectroscopy, Fourier Transform Infrared; D014867:Water / Q000737:chemistry
chemical_list: D014867:Water; D011142:Polyvinyl Alcohol; D002266:Carboxymethylcellulose Sodium