title: Comparison of short- and long-term outcomes between Cypher and TAXUS drug-eluting stents for in-stent restenosis.
abstract: OBJECTIVE
  To compare the short- and long-term clinical outcomes between sirolimus-eluting stent (Cypher stent) and paclitaxel-eluting stent (TAXUS stent) in patients with in-stent restenosis (ISR) lesions of the coronary arteries.
  
  
  METHODS
  From December 2002 to March 2005, 253 patients with ISR lesions of the coronary arteries were selected and divided into two groups. Cypher group (152 cases) was treated with Cypher or Cypher Select stents, and TAXUS group (101 cases) with TAXUS stents. A total of 262 ISR lesions in these patients were treated with 308 drug-eluting stents (DESs), including 176 Cypher or Cypher Select stents and 132 TAXUS stents. All patients were followed up for 10 months. Procedure success rates of DES implantation in both groups were observed. Major adverse cardiac events (MACE) rates in hospital and at 10 months follow-up, as well as in-DES restenosis observed using coronary angiography at follow-up were compared between two groups.
  
  
  RESULTS
  Success rate of DES implantation was 100% in both groups. No significant difference in MACE rate during hospitalization was found between the two groups. However, at 10 months follow-up, MACE rate was higher in TAXUS group than in Cypher group (16.00% vs. 6.67% , P = 0.031). As for coronary angiography at 10 months follow-up, we observed an increasing tendency of in-DES restenosis rate in TAXUS group compared with Cypher group (29.41% vs. 14.04%, P = 0.075).
  
  
  CONCLUSIONS
  Cypher and TAXUS DESs both have good short- and long-term outcomes in treating ISR. Cypher DES proved better long-term clinical outcome than TAXUS DES.
authors: Center for Diagnosis & Treatment of Coronary Heart Disease, Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100037. jilin.chen@263.net
authors: Ji-Lin
authors: JL
authors: Chen
authors: Yue-Jin
authors: YJ
authors: Yang
authors: Shu-Bin
authors: SB
authors: Qiao
authors: Min
authors: M
authors: Yao
authors: Xue-Wen
authors: XW
authors: Qin
authors: Bo
authors: B
authors: Xu
authors: Hai-Bo
authors: HB
authors: Liu
authors: Yong-Jian
authors: YJ
authors: Wu
authors: Jin-Qing
authors: JQ
authors: Yuan
authors: Jue
authors: J
authors: Chen
authors: Shi-Jie
authors: SJ
authors: You
authors: Jun
authors: J
authors: Dai
authors: Jian-Jun
authors: JJ
authors: Li
authors: Run-Lin
authors: RL
authors: Gao
mesh_terms: D000328:Adult; D000368:Aged; D000787:Angina Pectoris / Q000601:surgery; D003327:Coronary Disease / Q000401:mortality / Q000601:surgery*; D004867:Equipment Design; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000453:epidemiology; D015607:Stents / Q000009:adverse effects; D013997:Time Factors; D016896:Treatment Outcome