Piericidins C7 and C8, new cytotoxic antibiotics produced by a marine Streptomyces sp.
Piericidins C7 and C8, two new members of the piericidin family, were isolated from a marine actinomycete. The producing organism was identified as Streptomyces sp. based on the cultural, biochemical and chemotaxonomical characteristics as well as the 16S rRNA sequence. Piericidins C7 and C8 showed selective cytotoxicity against rat glia cells transformed with the adenovirus E1A gene (IC50 C7: 1.5 nM, C8: 0.45 nM) and Neuro-2a mouse neuroblastoma cells (IC50 C7: 0.83 nM, C8: 0.21 nM).
Hayakawa
Yoichi
Y
Faculty of Pharmaceutical Sciences, Tokyo University of Science, Noda, Chiba, Japan. hykw@rs.noda.tus.ac.jp
Shirasaki
Shingo
S
Shiba
Sayaka
S
Kawasaki
Takashi
T
Matsuo
Yoshihide
Y
Adachi
Kyoko
K
Shizuri
Yoshikazu
Y
D017500:Adenovirus E1A Proteins / Q000235:genetics; D000475:Alkenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D016923:Cell Death; D002455:Cell Division / Q000187:drug effects; D002461:Cell Line, Transformed; D045744:Cell Line, Tumor; D005285:Fermentation; D008386:Marine Biology; D009457:Neuroglia / Q000166:cytology / Q000187:drug effects*; D011725:Pyridines / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism* / Q000494:pharmacology; D051381:Rats; D013302:Streptomyces / Q000145:classification / Q000235:genetics / Q000254:growth & development / Q000378:metabolism*
D017500:Adenovirus E1A Proteins; D000475:Alkenes; D000903:Antibiotics, Antineoplastic; D011725:Pyridines; C520919:piericidin C7; C520918:piericidin C8