Animal models in gerontology research.
Animal models have paved the way for the vast majority of advances in biomedical research. Studies on aged animals are essential for understanding the processes inherent in normal aging and the progression of age-related diseases. Animal models are used to identify physiological changes with age, to identify the genetic basis of normal aging and age-associated disease and degeneration, and to test potential therapeutic interventions. This chapter will focus on rodent models and will summarize important considerations for the use of animals in aging research in general and in modeling geriatric epilepsy.
Nadon
Nancy L
NL
National Institute on Aging, Bethesda, Maryland 20892, USA.
D000818:Animals; D035843:Biomedical Research; D004195:Disease Models, Animal; D004827:Epilepsy; D005853:Geriatrics; D006801:Humans; D012377:Rodentia