title: 2-Aryl-2-hydroxyethylamine substituted 4-oxo-4,7-dihydrothieno[2,3-b]pyridines as broad-spectrum inhibitors of human herpesvirus polymerases.
abstract: A novel series of 2-aryl-2-hydroxyethylamine substituted 4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxamides have been identified as potent antivirals against human herpesviruses. These compounds demonstrate broad-spectrum inhibition of the herpesvirus polymerases HCMV, HSV-1, EBV, and VZV with high specificity compared to human DNA polymerases.
authors: Global Research and Development, Pfizer Inc., 700 Chesterfield Parkway West, St. Louis, MO 63017, USA. mark.e.schnute@pfizer.com
authors: Mark E
authors: ME
authors: Schnute
authors: David J
authors: DJ
authors: Anderson
authors: Roger J
authors: RJ
authors: Brideau
authors: Fred L
authors: FL
authors: Ciske
authors: Sarah A
authors: SA
authors: Collier
authors: Michele M
authors: MM
authors: Cudahy
authors: MariJean
authors: M
authors: Eggen
authors: Michael J
authors: MJ
authors: Genin
authors: Todd A
authors: TA
authors: Hopkins
authors: Thomas M
authors: TM
authors: Judge
authors: Euibong J
authors: EJ
authors: Kim
authors: Mary L
authors: ML
authors: Knechtel
authors: Sajiv K
authors: SK
authors: Nair
authors: James A
authors: JA
authors: Nieman
authors: Nancee L
authors: NL
authors: Oien
authors: Allen
authors: A
authors: Scott
authors: Steven P
authors: SP
authors: Tanis
authors: Valerie A
authors: VA
authors: Vaillancourt
authors: Michael W
authors: MW
authors: Wathen
authors: Janet L
authors: JL
authors: Wieber
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis / Q000494:pharmacology* / Q000627:therapeutic use; D001667:Binding, Competitive; D003587:Cytomegalovirus / Q000187:drug effects*; D004259:DNA-Directed DNA Polymerase; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology* / Q000627:therapeutic use; D005021:Ethylamines / Q000138:chemical synthesis / Q000494:pharmacology*; D005090:Exodeoxyribonucleases / Q000037:antagonists & inhibitors*; D006562:Herpes Zoster / Q000188:drug therapy; D006564:Herpesviridae / Q000187:drug effects* / Q000201:enzymology; D018259:Herpesvirus 1, Human / Q000187:drug effects*; D004854:Herpesvirus 4, Human / Q000187:drug effects*; D006801:Humans; D008956:Models, Chemical; D019384:Nucleic Acid Synthesis Inhibitors; D011725:Pyridines / Q000138:chemical synthesis / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014764:Viral Proteins / Q000037:antagonists & inhibitors*
chemical_list: D000998:Antiviral Agents; D004791:Enzyme Inhibitors; D005021:Ethylamines; D019384:Nucleic Acid Synthesis Inhibitors; D011725:Pyridines; D014764:Viral Proteins; D004259:DNA-Directed DNA Polymerase; D005090:Exodeoxyribonucleases; C043417:DNA polymerase, Simplexvirus