title: French brain tumor data bank: methodology and first results on 10,000 cases.
abstract: This work aims to prospectively record all primary central nervous system tumors (PCNST), in France, for which histological diagnosis is available. The objectives are to create a national registry and a network to perform epidemiological studies, to implement clinical and basic research protocols, and to harmonize the healthcare of patients affected by PCNST. Following a feasibility study, including an estimate of the gross incidence of PCNST (15.8/100,000 person-years) in France, all French neuropathology and neurosurgery departments decided to participate in the program. For each patient, the neurosurgeon and the neuropathologist complete a data file containing socio-demographic, clinical, radiologic and anatomopathologic information. The Tumor Registry from Herault is authorized to compile the data files with personal identifiers. In 2.5 years, 10,093 cases of newly diagnosed PCNST have been recorded. Tumor resections were performed in 75.3%, while biopsies accounted for 24.7%. Histological diagnoses included glioma (49.6%), other neuroepithelial tumors (3.8%), meningioma (30.9%), neurinoma (8.7%), lymphoma (2.9%) and others (4.1%). Cryopreservation was reported for 2,261 PCNST specimens. Clinical and radiological aspects were also recorded. Preliminary results are encouraging and stimulating for the long-term goal of creating a National Registry and a National Network for patients affected by PCNST. To our knowledge, this is the first European databank dedicated to PCNST, with collection of clinical, radiological and histological data (including cryopreservation of the specimen). The creation of this registry and this database may have major clinical and fundamental implications.
authors: Department of Neurosurgery, Centre Hospitalo-Universitaire, Hôpital Gui de Chauliac, 80 Avenue Augustin Fliche, 34295 Montpellier cedex 5, France. l-bauchet@chu-montpellier.fr
authors: Luc
authors: L
authors: Bauchet
authors: Valérie
authors: V
authors: Rigau
authors: Hélène
authors: H
authors: Mathieu-Daudé
authors: Dominique
authors: D
authors: Figarella-Branger
authors: Delphine
authors: D
authors: Hugues
authors: Loreleï
authors: L
authors: Palusseau
authors: Fabienne
authors: F
authors: Bauchet
authors: Michel
authors: M
authors: Fabbro
authors: Chantal
authors: C
authors: Campello
authors: Laurent
authors: L
authors: Capelle
authors: Anne
authors: A
authors: Durand
authors: Brigitte
authors: B
authors: Trétarre
authors: Didier
authors: D
authors: Frappaz
authors: Dominique
authors: D
authors: Henin
authors: Philippe
authors: P
authors: Menei
authors: Jérome
authors: J
authors: Honnorat
authors: François
authors: F
authors: Segnarbieux
mesh_terms: D001932:Brain Neoplasms / Q000145:classification* / Q000453:epidemiology / Q000473:pathology*; D016208:Databases, Factual; D005260:Female; D005602:France; D006801:Humans; D008297:Male; D008875:Middle Aged