title: Evolutionary and biomedical insights from the rhesus macaque genome.
abstract: The rhesus macaque (Macaca mulatta) is an abundant primate species that diverged from the ancestors of Homo sapiens about 25 million years ago. Because they are genetically and physiologically similar to humans, rhesus monkeys are the most widely used nonhuman primate in basic and applied biomedical research. We determined the genome sequence of an Indian-origin Macaca mulatta female and compared the data with chimpanzees and humans to reveal the structure of ancestral primate genomes and to identify evidence for positive selection and lineage-specific expansions and contractions of gene families. A comparison of sequences from individual animals was used to investigate their underlying genetic diversity. The complete description of the macaque genome blueprint enhances the utility of this animal model for biomedical research and improves our understanding of the basic biology of the species.
authors: Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA. agibbs@bcm.edu
authors: Richard A
authors: RA
authors: Gibbs
authors: Jeffrey
authors: J
authors: Rogers
authors: Michael G
authors: MG
authors: Katze
authors: Roger
authors: R
authors: Bumgarner
authors: George M
authors: GM
authors: Weinstock
authors: Elaine R
authors: ER
authors: Mardis
authors: Karin A
authors: KA
authors: Remington
authors: Robert L
authors: RL
authors: Strausberg
authors: J Craig
authors: JC
authors: Venter
authors: Richard K
authors: RK
authors: Wilson
authors: Mark A
authors: MA
authors: Batzer
authors: Carlos D
authors: CD
authors: Bustamante
authors: Evan E
authors: EE
authors: Eichler
authors: Matthew W
authors: MW
authors: Hahn
authors: Ross C
authors: RC
authors: Hardison
authors: Kateryna D
authors: KD
authors: Makova
authors: Webb
authors: W
authors: Miller
authors: Aleksandar
authors: A
authors: Milosavljevic
authors: Robert E
authors: RE
authors: Palermo
authors: Adam
authors: A
authors: Siepel
authors: James M
authors: JM
authors: Sikela
authors: Tony
authors: T
authors: Attaway
authors: Stephanie
authors: S
authors: Bell
authors: Kelly E
authors: KE
authors: Bernard
authors: Christian J
authors: CJ
authors: Buhay
authors: Mimi N
authors: MN
authors: Chandrabose
authors: Marvin
authors: M
authors: Dao
authors: Clay
authors: C
authors: Davis
authors: Kimberly D
authors: KD
authors: Delehaunty
authors: Yan
authors: Y
authors: Ding
authors: Huyen H
authors: HH
authors: Dinh
authors: Shannon
authors: S
authors: Dugan-Rocha
authors: Lucinda A
authors: LA
authors: Fulton
authors: Ramatu Ayiesha
authors: RA
authors: Gabisi
authors: Toni T
authors: TT
authors: Garner
authors: Jennifer
authors: J
authors: Godfrey
authors: Alicia C
authors: AC
authors: Hawes
authors: Judith
authors: J
authors: Hernandez
authors: Sandra
authors: S
authors: Hines
authors: Michael
authors: M
authors: Holder
authors: Jennifer
authors: J
authors: Hume
authors: Shalini N
authors: SN
authors: Jhangiani
authors: Vandita
authors: V
authors: Joshi
authors: Ziad Mohid
authors: ZM
authors: Khan
authors: Ewen F
authors: EF
authors: Kirkness
authors: Andrew
authors: A
authors: Cree
authors: R Gerald
authors: RG
authors: Fowler
authors: Sandra
authors: S
authors: Lee
authors: Lora R
authors: LR
authors: Lewis
authors: Zhangwan
authors: Z
authors: Li
authors: Yih-Shin
authors: YS
authors: Liu
authors: Stephanie M
authors: SM
authors: Moore
authors: Donna
authors: D
authors: Muzny
authors: Lynne V
authors: LV
authors: Nazareth
authors: Dinh Ngoc
authors: DN
authors: Ngo
authors: Geoffrey O
authors: GO
authors: Okwuonu
authors: Grace
authors: G
authors: Pai
authors: David
authors: D
authors: Parker
authors: Heidie A
authors: HA
authors: Paul
authors: Cynthia
authors: C
authors: Pfannkoch
authors: Craig S
authors: CS
authors: Pohl
authors: Yu-Hui
authors: YH
authors: Rogers
authors: San Juana
authors: SJ
authors: Ruiz
authors: Aniko
authors: A
authors: Sabo
authors: Jireh
authors: J
authors: Santibanez
authors: Brian W
authors: BW
authors: Schneider
authors: Scott M
authors: SM
authors: Smith
authors: Erica
authors: E
authors: Sodergren
authors: Amanda F
authors: AF
authors: Svatek
authors: Teresa R
authors: TR
authors: Utterback
authors: Selina
authors: S
authors: Vattathil
authors: Wesley
authors: W
authors: Warren
authors: Courtney Sherell
authors: CS
authors: White
authors: Asif T
authors: AT
authors: Chinwalla
authors: Yucheng
authors: Y
authors: Feng
authors: Aaron L
authors: AL
authors: Halpern
authors: Ladeana W
authors: LW
authors: Hillier
authors: Xiaoqiu
authors: X
authors: Huang
authors: Pat
authors: P
authors: Minx
authors: Joanne O
authors: JO
authors: Nelson
authors: Kymberlie H
authors: KH
authors: Pepin
authors: Xiang
authors: X
authors: Qin
authors: Granger G
authors: GG
authors: Sutton
authors: Eli
authors: E
authors: Venter
authors: Brian P
authors: BP
authors: Walenz
authors: John W
authors: JW
authors: Wallis
authors: Kim C
authors: KC
authors: Worley
authors: Shiaw-Pyng
authors: SP
authors: Yang
authors: Steven M
authors: SM
authors: Jones
authors: Marco A
authors: MA
authors: Marra
authors: Mariano
authors: M
authors: Rocchi
authors: Jacqueline E
authors: JE
authors: Schein
authors: Robert
authors: R
authors: Baertsch
authors: Laura
authors: L
authors: Clarke
authors: Miklós
authors: M
authors: Csürös
authors: Jarret
authors: J
authors: Glasscock
authors: R Alan
authors: RA
authors: Harris
authors: Paul
authors: P
authors: Havlak
authors: Andrew R
authors: AR
authors: Jackson
authors: Huaiyang
authors: H
authors: Jiang
authors: Yue
authors: Y
authors: Liu
authors: David N
authors: DN
authors: Messina
authors: Yufeng
authors: Y
authors: Shen
authors: Henry Xing-Zhi
authors: HX
authors: Song
authors: Todd
authors: T
authors: Wylie
authors: Lan
authors: L
authors: Zhang
authors: Ewan
authors: E
authors: Birney
authors: Kyudong
authors: K
authors: Han
authors: Miriam K
authors: MK
authors: Konkel
authors: Jungnam
authors: J
authors: Lee
authors: Arian F A
authors: AF
authors: Smit
authors: Brygg
authors: B
authors: Ullmer
authors: Hui
authors: H
authors: Wang
authors: Jinchuan
authors: J
authors: Xing
authors: Richard
authors: R
authors: Burhans
authors: Ze
authors: Z
authors: Cheng
authors: John E
authors: JE
authors: Karro
authors: Jian
authors: J
authors: Ma
authors: Brian
authors: B
authors: Raney
authors: Xinwei
authors: X
authors: She
authors: Michael J
authors: MJ
authors: Cox
authors: Jeffery P
authors: JP
authors: Demuth
authors: Laura J
authors: LJ
authors: Dumas
authors: Sang-Gook
authors: SG
authors: Han
authors: Janet
authors: J
authors: Hopkins
authors: Anis
authors: A
authors: Karimpour-Fard
authors: Young H
authors: YH
authors: Kim
authors: Jonathan R
authors: JR
authors: Pollack
authors: Tomas
authors: T
authors: Vinar
authors: Charles
authors: C
authors: Addo-Quaye
authors: Jeremiah
authors: J
authors: Degenhardt
authors: Alexandra
authors: A
authors: Denby
authors: Melissa J
authors: MJ
authors: Hubisz
authors: Amit
authors: A
authors: Indap
authors: Carolin
authors: C
authors: Kosiol
authors: Bruce T
authors: BT
authors: Lahn
authors: Heather A
authors: HA
authors: Lawson
authors: Alison
authors: A
authors: Marklein
authors: Rasmus
authors: R
authors: Nielsen
authors: Eric J
authors: EJ
authors: Vallender
authors: Andrew G
authors: AG
authors: Clark
authors: Betsy
authors: B
authors: Ferguson
authors: Ryan D
authors: RD
authors: Hernandez
authors: Kashif
authors: K
authors: Hirani
authors: Hildegard
authors: H
authors: Kehrer-Sawatzki
authors: Jessica
authors: J
authors: Kolb
authors: Shobha
authors: S
authors: Patil
authors: Ling-Ling
authors: LL
authors: Pu
authors: Yanru
authors: Y
authors: Ren
authors: David Glenn
authors: DG
authors: Smith
authors: David A
authors: DA
authors: Wheeler
authors: Ian
authors: I
authors: Schenck
authors: Edward V
authors: EV
authors: Ball
authors: Rui
authors: R
authors: Chen
authors: David N
authors: DN
authors: Cooper
authors: Belinda
authors: B
authors: Giardine
authors: Fan
authors: F
authors: Hsu
authors: W James
authors: WJ
authors: Kent
authors: Arthur
authors: A
authors: Lesk
authors: David L
authors: DL
authors: Nelson
authors: William E
authors: WE
authors: O'brien
authors: Kay
authors: K
authors: Prüfer
authors: Peter D
authors: PD
authors: Stenson
authors: James C
authors: JC
authors: Wallace
authors: Hui
authors: H
authors: Ke
authors: Xiao-Ming
authors: XM
authors: Liu
authors: Peng
authors: P
authors: Wang
authors: Andy Peng
authors: AP
authors: Xiang
authors: Fan
authors: F
authors: Yang
authors: Galt P
authors: GP
authors: Barber
authors: David
authors: D
authors: Haussler
authors: Donna
authors: D
authors: Karolchik
authors: Andy D
authors: AD
authors: Kern
authors: Robert M
authors: RM
authors: Kuhn
authors: Kayla E
authors: KE
authors: Smith
authors: Ann S
authors: AS
authors: Zwieg
mesh_terms: D000818:Animals; D035843:Biomedical Research; D019143:Evolution, Molecular; D005260:Female; D020440:Gene Duplication; D015321:Gene Rearrangement; D030342:Genetic Diseases, Inborn; D014644:Genetic Variation; D016678:Genome; D006801:Humans; D008253:Macaca mulatta / Q000235:genetics*; D008297:Male; D005810:Multigene Family; D009154:Mutation; D002679:Pan troglodytes / Q000235:genetics; D017422:Sequence Analysis, DNA; D013045:Species Specificity