title: [Impact of highly active antiretroviral therapy on plasma MCP-1 and MSP in AIDS patients].
abstract: To study the effect of highly active antiretroviral therapy (HAART) on plasma levels of MSP and MCP-1 in AIDS patients.
  
  
  
  Forty Chinese AIDS patients were treated with HAART for 3 months and 84 German AIDS patients with HAART for 3 to 6 years. The pre-treatment and post-treatment plasma levels of MSP and MCP-1 were measured by enzyme-linked immunosorbent assay (ELISA), and their correlations with CD4+ cell counts and viral loads were analyzed.
  
  
  
  The mean levels of MCP-1 were significantly higher and MSP were significantly lower in HIV-infected patients compared with the HIV-negative controls (P <0.01). After HAART for three months, there were no significant changes in the levels of these cytokines. But after long-term HAART (for 3 to 6 y), the level of MCP-1 was increased and that of MSP decreased significantly (P<0.01). There was a negative correlation between MSP and MCP-1 levels, and the same for MSP level and CD4+ cell counts; while there was a positive correlation between MCP-1 levels and CD4+ cell counts.
  
  
  
  The changed plasma levels of MSP and MCP-1 are associated with HIV-1 infection and HAART may reverse the levels of these two cytokines.
authors: The Institute of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China.
authors: Hang-Ping
authors: HP
authors: Yao
authors: Chang-Zhong
authors: CZ
authors: Jin
authors: Fu-Jie
authors: FJ
authors: Zhang
authors: Lei
authors: L
authors: Feng
authors: Hong-Shan
authors: HS
authors: Wei
authors: Ling-Jiao
authors: LJ
authors: Wu
authors: Gui-Ju
authors: GJ
authors: Gao
authors: Bader
authors: B
authors: Armin
authors: Brockmeyer
authors: B
authors: Norbert
authors: Nan-Ping
authors: NP
authors: Wu
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000097:blood* / Q000188:drug therapy*; D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D018932:Chemokine CCL2 / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D016215:Macrophage-Activating Factors / Q000097:blood*; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D019380:Anti-HIV Agents; D018932:Chemokine CCL2; D016215:Macrophage-Activating Factors