title: A model system for analyzing somatic mutations in Drosophila melanogaster.
abstract: Presently there are no good assays for comparing somatic mutation frequencies and spectra between different vertebrate and invertebrate organisms. Here we describe a new lacZ mutation reporter system in D. melanogaster, which complements existing systems in the mouse. The results obtained with the new model indicate two-to threefold higher frequencies of spontaneous mutations than in the mouse, with most of the mutations characterized as large genome rearrangements.
authors: University of Texas at San Antonio, San Antonio, Texas 78249, USA.
authors: Ana Maria
authors: AM
authors: Garcia
authors: Anastasia
authors: A
authors: Derventzi
authors: Rita
authors: R
authors: Busuttil
authors: R Brent
authors: RB
authors: Calder
authors: Ernesto
authors: E
authors: Perez
authors: Linda
authors: L
authors: Chadwell
authors: Martijn E T
authors: ME
authors: Dollé
authors: Martha
authors: M
authors: Lundell
authors: Jan
authors: J
authors: Vijg
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified; D004331:Drosophila melanogaster / Q000235:genetics*; D005260:Female; D007763:Lac Operon / Q000235:genetics*; D008297:Male; D008957:Models, Genetic; D009154:Mutation; D015265:Site-Specific DNA-Methyltransferase (Adenine-Specific) / Q000378:metabolism
chemical_list: C090528:DNA modification methylase HindIII; D015265:Site-Specific DNA-Methyltransferase (Adenine-Specific)