Sensory processing disorders in a nonhuman primate model: evidence for occupational therapy practice.
Evaluation of sensory processing function serves as a critical component of treatment planning and implementation of intervention in pediatric occupational therapy practice. We developed a Sensory Processing Scale for Monkeys (SPS-M), based on human tests, that measures behavioral responses to a series of tactile stimuli. This assessment has been used to assess sensory processing in adult rhesus monkeys exposed to prenatal alcohol, stress, or postnatal lead. Control monkeys from undisturbed pregnancies showed a habituation pattern, prenatally stressed monkeys showed sensitization, and prenatal alcohol-exposed monkeys showed relatively high responsiveness without habituation across trials. Lead-exposed monkeys showed sensitization compared to nonlead-exposed controls, and chelation reduced the sensitization in lead-exposed animals. Aversive responsiveness was associated with up-regulated striatal dopamine receptor binding measured with positron emission tomography.
Schneider
Mary L
ML
Department of Kinesiology, Occupational Therapy Program, University of Wisconsin-Madison, 2175 Medical Sciences Center, 1300 University Avenue, Madison, WI 53706-1532, USA. schneider@education.wisc.edu
Moore
Colleen F
CF
Gajewski
Lisa L
LL
Laughlin
Nellie K
NK
Larson
Julie A
JA
Gay
Cynthia L
CL
Roberts
Andrew D
AD
Converse
Alexander K
AK
DeJesus
Onofre T
OT
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D000431:Ethanol / Q000633:toxicity; D019317:Evidence-Based Medicine; D005260:Female; D007854:Lead / Q000097:blood / Q000633:toxicity; D008253:Macaca mulatta / Q000502:physiology*; D018811:Maternal Exposure; D023421:Models, Animal; D009622:Noise / Q000009:adverse effects; D009788:Occupational Therapy; D010812:Physical Stimulation; D011247:Pregnancy; D011897:Random Allocation; D020886:Somatosensory Disorders / Q000139:chemically induced / Q000209:etiology*; D013315:Stress, Psychological / Q000150:complications; D014481:United States
D007854:Lead; D000431:Ethanol