title: Assessment of hemodynamics in precancerous lesion of hepatocellular carcinoma: evaluation with MR perfusion.
abstract: OBJECTIVE
  To investigate the hemodynamic changes in a precancerous lesion model of hepatocellular carcinoma (HCC).
  
  
  METHODS
  Hemodynamic changes in 18 Wistar rats were studied with non-invasive magnetic resonance (MR) perfusion. The changes induced by diethylnitrosamine (DEN) developed into liver nodular lesions due to hepatic cirrhosis during the progression of carcinogenesis. The MR perfusion data [positive enhancement integral (PEI)] were compared between the nodular lesions corresponding well with MR images and pathology and their surrounding hepatic parenchyma.
  
  
  RESULTS
  A total of 46 nodules were located by MR imaging and autopsy, including 22 dysplastic nodules (DN), 9 regenerative nodules (RN), 10 early HCCs and 5 overt HCCs. Among the 22 DNs, 6 were low-grade DN (LGDN) and 16 were high-grade DN (HGDN). The average PEI of RN, DN, early and overt HCC was 205.67 +/- 31.17, 161.94 +/- 20.74, 226.09 +/- 34.83, 491.86 +/- 44.61 respectively, and their liver parenchyma nearby was 204.84 +/- 70.19. Comparison of the blood perfusion index between each RN and its surrounding hepatic parenchyma showed no statistically significant difference (P = 0.06). There were significant differences in DN (P = 0.02). During the late hepatic arterial phase, the perfusion curve in DN declined. DN had an iso-signal intensity at the early hepatic arterial phase and a low signal intensity at the portal venous phase. Of the 10 early HCCs, 4 demonstrated less blood perfusion and 6 displayed minimally increased blood flow compared to the surrounding parenchyma. Five HCCs showed significantly increased blood supply compared to the surrounding parenchyma (P = 0.02).
  
  
  CONCLUSIONS
  Non-invasive MR perfusion can detect changes in blood supply of precancerous lesions.
authors: Department of Radiology, 1st Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, Henan Province, China.
authors: Sheng
authors: S
authors: Guan
authors: Wei-Dong
authors: WD
authors: Zhao
authors: Kang-Rong
authors: KR
authors: Zhou
authors: Wei-Jun
authors: WJ
authors: Peng
authors: Feng
authors: F
authors: Tang
authors: Jian
authors: J
authors: Mao
mesh_terms: D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis / Q000503:physiopathology*; D008102:Liver Circulation / Q000502:physiology*; D008113:Liver Neoplasms / Q000175:diagnosis / Q000503:physiopathology*; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D011230:Precancerous Conditions / Q000175:diagnosis / Q000503:physiopathology*; D051381:Rats; D017208:Rats, Wistar