Selective and potent in vitro antimalarial activities found in four microbial metabolites.
Antimalarial activities have been identified in four microbial metabolites through a screening programme of existing compounds in the Kitasato Institute chemical library. Hedamycin showed selective and potent activity against both drug-resistant and drug-sensitive strains of Plasmodium falciparum. Simaomicin alpha exhibited remarkably strong antimalarial activity, although its activity against a drug-resistant strain was weaker than that against a drug-sensitive strain. The antimalarial effects of triacsins C and D are also reported.
Ui
Hideaki
H
Ishiyama
Aki
A
Sekiguchi
Hitomi
H
Namatame
Miyuki
M
Nishihara
Aki
A
Takahashi
Yoko
Y
Shiomi
Kazuro
K
Otoguro
Kazuhiko
K
Omura
Satoshi
S
D000818:Animals; D000880:Anthraquinones / Q000737:chemistry / Q000494:pharmacology*; D000962:Antimalarials / Q000494:pharmacology*; D004351:Drug Resistance; D007546:Isoquinolines / Q000737:chemistry / Q000494:pharmacology*; D021261:Parasitic Sensitivity Tests; D010963:Plasmodium falciparum / Q000187:drug effects*; D014226:Triazenes / Q000737:chemistry / Q000494:pharmacology*
D000880:Anthraquinones; D000962:Antimalarials; D007546:Isoquinolines; D014226:Triazenes; C066125:simaomicin alpha; C001328:hedamycin; C034613:triacsin C; C034614:triacsin D