[T-cell rich B-cell lymphoma associated with neutrophilia and thrombocytosis].
A 49-year-old man was admitted with high-grade fever, night sweating and cervical lymphadenopathy in September 2005. On examination, both neutrophilia and thrombocytosis were noted in the peripheral blood, a bone marrow examination revealed marked both myeloid and megakaryocytic hyperplasia. The sera obtained at initial presentation showed an elevated levels of granulocyte-colony stimulating factor (G-CSF) and interleukin-6 (IL-6). A pathologic diagnosis of T-cell rich B-cell lymphoma was made based on an inguinal lymph node biopsy. Following treatment with CHOP accompanied by rituximab (R-CHOP), both the neutrophilia and thrombocytosis subsided after 3 courses of R-CHOP, resulting in a complete remission after 4 courses of chemotherapy. Neutrophilia, thrombocytosis and T-cell rich B-cell lymphoma in this patient were considerably ameliorated with chemotherapy. We report here a patient with T-cell rich B-cell lymphoma associated with both neutrophilia and thrombocytosis, suggesting that the lymphoma triggered both myeloid and megakaryocytic hyperplasia.
Kuroda
Hiroyuki
H
Department of Internal Medicine, Higashi Sapporo Hospital.
Matsunaga
Takuya
T
Sakamaki
Sumio
S
Koike
Kazuhiko
K
Terui
Takeshi
T
Neda
Hiroshi
H
Ishitani
Kunihiko
K
Nobuoka
Atsushi
A
Sato
Mutsumi
M
Kida
Masaya
M
Watanabe
Hideki
H
Yamaguchi
Jun
J
Niitsu
Yoshiro
Y
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D016179:Granulocyte Colony-Stimulating Factor / Q000097:blood; D006801:Humans; D006965:Hyperplasia; D015850:Interleukin-6 / Q000097:blood; D007964:Leukocytosis / Q000209:etiology*; D018655:Lymphocyte Count; D016393:Lymphoma, B-Cell / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology; D008297:Male; D008533:Megakaryocytes / Q000473:pathology; D008875:Middle Aged; D022423:Myeloid Cells / Q000473:pathology; D009504:Neutrophils; D013601:T-Lymphocytes; D013922:Thrombocytosis / Q000209:etiology*; D016896:Treatment Outcome
D015850:Interleukin-6; D016179:Granulocyte Colony-Stimulating Factor