The role of angiopoietin 2 in hyperoxia-induced acute lung injury.
Hyperoxia-induced acute lung injury (HALI) is characterized by an influx of inflammatory cells, increased pulmonary permeability, endothelial and epithelial cell death. In a murine model and in vitro, we found Angiopoietin 2 to be a critical mediator of lung oxidant injury, inflammation, edema, and regulator of necrotic cell death pathways. The clinical significance of our findings was highlighted by the detection of increased Angiopoietin 2 levels in patients with ALI.
Bhandari
Vineet
V
Divison of Perinatal Medicine, Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut, USA. vineet.bhandari@yale.edu
Elias
Jack A
JA
D042702:Angiopoietin-2 / Q000502:physiology*; D000818:Animals; D016923:Cell Death; D004195:Disease Models, Animal; D006801:Humans; D018496:Hyperoxia / Q000150:complications*; D008954:Models, Biological; D012128:Respiratory Distress Syndrome / Q000209:etiology*
D042702:Angiopoietin-2