title: Chorionic villus sampling significantly affects fetal cardiovascular function.
abstract: OBJECTIVE
  To assess the effects of chorionic villus sampling (CVS) on fetal heart rate (FHR).
  
  
  METHODS
  A prospective longitudinal study was conducted among 300 patients undergoing transabdominal CVS between 8 and 13 weeks of gestation. Duration of the procedure, number of needle passes, sample weight, maternal age, fetal gender, and FHR response to CVS were recorded.
  
  
  RESULTS
  The FHR before but not after CVS was inversely correlated with gestational age (r = -0.406, p < 0.001). Conversely, following CVS, no correlation was observed between FHR and gestational age (r = -0.06, p = 0.27). The difference between FHR after CVS and that obtained before CVS (delta FHR) increased with increasing gestational age at sampling (r = 0.372, p < 0.0001), decreased with increasing specimen weight (r = -0.16, p = 0.01) and increased with increasing maternal age (r = 0.22, p < 0.0001). Duration of the procedure, fetal gender and number of needle passes did not affect delta FHR. Multiple logistic regression indicated that gestational age at CVS and maternal age but not the other variables significantly affected delta FHR and together they accounted for over 22% of the variance (R(2) = 0.224, p < 0.0001).
  
  
  CONCLUSIONS
  In summary, our results suggest that acute fetal hemodynamic changes accompany CVS and that these changes vary with gestational age.
authors: Institute of Obstetrics and Gynecology, University of Belgrade, Belgrade, Serbia.
authors: Nebojsa
authors: N
authors: Radunovic
authors: Edward
authors: E
authors: Kuczynski
authors: Olivera
authors: O
authors: Kontic
authors: Vladimir
authors: V
authors: Kanjuh
authors: Charles J
authors: CJ
authors: Lockwood
mesh_terms: D000328:Adult; D001145:Arrhythmias, Cardiac / Q000196:embryology / Q000209:etiology* / Q000503:physiopathology; D015193:Chorionic Villi Sampling / Q000009:adverse effects*; D005260:Female; D005865:Gestational Age; D006340:Heart Rate, Fetal; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D011247:Pregnancy; D011446:Prospective Studies