Proteomic analysis of the serum in patients with idiopathic pulmonary arterial hypertension.
Idiopathic pulmonary arterial hypertension (IPAH) is a rare disease of unknown etiology. The exact pathogenesis of pulmonary arterial hypertension is still not well known. In the past decades, many protein molecules have been found to be involved in the development of IPAH. With proteomic techniques, profiling of human plasma proteome becomes more feasible in searching for disease-related markers. In present study, we showed the protein expression profiles of the serum of IPAH and healthy controls after depleting a few high-abundant proteins in serum. Thirteen spots had changed significantly in IPAH compared with healthy controls and were identified by LC-MS/MS. Alpha-1-antitrypsin and vitronectin were down-regulated in IPAH and may be valuable candidates for further explorations of their roles in the development of IPAH.
Yu
Min
M
Department of Cardiovascular Disease, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China.
Wang
Xing-xiang
XX
Zhang
Fu-rong
FR
Shang
Yun-peng
YP
Du
Yu-xi
YX
Chen
Hong-juan
HJ
Chen
Jun-zhu
JZ
D001798:Blood Proteins / Q000032:analysis* / Q000235:genetics; D030562:Databases, Protein; D015180:Electrophoresis, Gel, Two-Dimensional; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D006976:Hypertension, Pulmonary / Q000097:blood* / Q000235:genetics; D040901:Proteomics
D001798:Blood Proteins