title: Computer-aided mass detection based on ipsilateral multiview mammograms.
abstract: OBJECTIVE
  Recent reports on advances in computer-aided detection (CAD) indicate that current schemes miss early-stage breast cancers and result in a relatively large false-positive detection rate in order to achieve a high sensitivity rate for mass detection. This paper is inspired by the interpretation procedure from mammographers. The abnormal diagnosis can be derived from multiple views but is not available through single-view image analysis.
  
  
  METHODS
  A new multiview CAD system for early-stage breast cancer detection, which is based on modifying the optimized CAD algorithms from our prior single-view CAD system for constructing an adaptive ipsilateral multiview concurrent CAD system, is presented in this paper. The selection and design for the training and testing ipsilateral multiview mammogram databases are described here.
  
  
  RESULTS
  The performance evaluation of the developed ipsilateral multiview CAD system using free-response receiver operating characteristic analysis and computerized receiver operating characteristic experiments are presented. The results indicated that the proposed multiview CAD system is significantly superior to the single-view CAD systems based on statistically standard P-values.
  
  
  CONCLUSIONS
  This paper addresses a very important and timely project. It is related to two main problems regarding the development of breast cancer detection and diagnosis: early-stage detection and diagnosis of breast cancer with digital mammogram, and overall improvement of CAD system performance for clinical implementation. In order to improve the efficacy, accuracy, and efficiency of the current CAD scheme, an entirely new class of CAD method is required. This paper is unique in that a comprehensive and state-of-the-art approach is proposed for the CAD scheme of digital mammography. From the design aspect of the CAD scheme, the proposed ipsilateral multiview CAD method is innovative and quite different from current single-view CAD methods.
authors: Department of Interdisciplinary Oncology and Radiology, H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, 12902 Magnolia Drive, Tampa, FL 33612-9497, USA. qianw@moffitt.usf.edu
authors: Wei
authors: W
authors: Qian
authors: Dansheng
authors: D
authors: Song
authors: Minshan
authors: M
authors: Lei
authors: Ravi
authors: R
authors: Sankar
authors: Edward
authors: E
authors: Eikman
mesh_terms: D000465:Algorithms; D001943:Breast Neoplasms / Q000000981:diagnostic imaging*; D003663:Decision Trees; D042241:Early Diagnosis; D005260:Female; D017143:Fuzzy Logic; D006801:Humans; D008327:Mammography; D016571:Neural Networks, Computer; D012372:ROC Curve; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods*