Loss of heterozygosity studies in extracranial metastatic meningiomas.
Although most meningiomas are slow-growing tumours associated with favourable prognosis, they often present local recurrence after surgical treatment; by contrast, extracranial metastatic meningiomas are rare, occurring in less than 1% of the cases. Risk factors for distal spread remain largely unknown. We report three cases with lung or bone metastases from intracranial recurrent meningiomas. Loss of heterozygosity (LOH) analysis on 1p, 9p, 10q, 14q, and 22q was conducted in available primary, recurrent and metastatic lesions, showing the same LOH pattern in the distal metastases and in the intracranial meningioma. LOH at 1p, 14q and 9p, known to be associated with increased aggressiveness, were found. The results highlight the potential clinical relevance of integrating histopathological studies with molecular genetic analysis in the follow-up of patients with different types of meningiomas.
Gladin
Caroline Regna
CR
Department of Experimental Neurology and Diagnostics, Fondazione IRCCS Istituto Neurologico Besta, Milano, Italy.
Salsano
Ettore
E
Menghi
Francesca
F
Grisoli
Marina
M
Ghielmetti
Francesco
F
Milanesi
Ida
I
Pollo
Bianca
B
Brock
Stefano
S
Cusin
Alberto
A
Minati
Ludovico
L
Finocchiaro
Gaetano
G
Bruzzone
Maria Grazia
MG
D000328:Adult; D001859:Bone Neoplasms / Q000235:genetics / Q000556:secondary; D001921:Brain / Q000473:pathology; D002875:Chromosomes / Q000235:genetics; D004273:DNA, Neoplasm / Q000235:genetics; D006801:Humans; D019656:Loss of Heterozygosity / Q000502:physiology*; D008175:Lung Neoplasms / Q000235:genetics / Q000556:secondary; D008297:Male; D008579:Meningioma / Q000235:genetics* / Q000473:pathology / Q000556:secondary*; D008875:Middle Aged; D009362:Neoplasm Metastasis; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014057:Tomography, X-Ray Computed
D004273:DNA, Neoplasm