Towards a multiscale model of colorectal cancer.
Colorectal cancer (CRC) is one of the best characterised cancers, with extensive data documenting the sequential gene mutations that underlie its development. Complementary datasets are also being generated describing changes in protein and RNA expression, tumour biology and clinical outcome. Both the quantity and the variety of information are inexorably increasing and there is now an accompanying need to integrate these highly disparate datasets. In this article we aim to explain why we believe that mathematical modelling represents a natural tool or language with which to integrate these data and, in so doing, to provide insight into CRC.
van Leeuwen
Ingeborg M M
IM
Centre for Mathematical Medicine and Biology, School of Mathematical Sciences, University of Nottingham, Nottingham NG7 2RD, United Kingdom.
Edwards
Carina M
CM
Ilyas
Mohammad
M
Byrne
Helen M
HM
D017209:Apoptosis / Q000502:physiology; D002454:Cell Differentiation / Q000502:physiology; D002465:Cell Movement / Q000502:physiology; D049109:Cell Proliferation; D015179:Colorectal Neoplasms / Q000209:etiology / Q000473:pathology* / Q000503:physiopathology*; D006801:Humans; D008962:Models, Theoretical; D015398:Signal Transduction / Q000502:physiology; D013269:Stochastic Processes