title: The effects of concentrated barley beta-glucan on blood lipids in a population of hypercholesterolaemic men and women.
abstract: Barley, like oats, is a rich source of the soluble fibre beta-glucan, which has been shown to significantly lower LDL-cholesterol (LDL-C). However, barley foods have been less widely studied. Therefore, we evaluated the LDL-C-lowering effect of a concentrated barley beta-glucan (BBG) extract as a vehicle to deliver this potential health benefit of barley. In a 10-week blinded controlled study, subjects were randomized to one of four treatment groups or control. Treatment groups included either high molecular weight (HMW) or low molecular weight (LMW) BBG at both 3 and 5 g doses. Treatment was delivered twice per day with meals in the form of two functional food products: a ready-to-eat cereal and a reduced-calorie fruit juice beverage. Levels of total cholesterol, LDL-C, HDL-cholesterol (HDL-C), and TAG were determined at baseline and after 6 weeks of treatment. The study group comprised 155 subjects. All treatments were well tolerated and after 6 weeks of treatment the mean LDL-C levels fell by 15 % in the 5 g HMW group, 13 % in the 5 g LMW group and 9 % in both the 3 g/d groups, versus baseline. Similar results were observed for total cholesterol. HDL-C levels were unchanged by treatment. Concentrated BBG significantly improves LDL-C and total cholesterol among moderately dyslipidaemic subjects. Food products containing concentrated BBG should be considered an effective option for improving blood lipids.
authors: University of Minnesota, Medical School, Department of Family Medicine and Community Health, MMC 381, Minneapolis, MN 55455, USA. keena001@umn.edu
authors: Joseph M
authors: JM
authors: Keenan
authors: Melanie
authors: M
authors: Goulson
authors: Tatyana
authors: T
authors: Shamliyan
authors: Nathan
authors: N
authors: Knutson
authors: Lore
authors: L
authors: Kolberg
authors: Leslie
authors: L
authors: Curry
mesh_terms: D000328:Adult; D000368:Aged; D008078:Cholesterol, LDL / Q000097:blood; D004043:Dietary Fiber / Q000008:administration & dosage / Q000627:therapeutic use; D004311:Double-Blind Method; D005260:Female; D005527:Food, Fortified; D001467:Hordeum; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000178:diet therapy*; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome; D047071:beta-Glucans / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D008078:Cholesterol, LDL; D004043:Dietary Fiber; D008055:Lipids; D047071:beta-Glucans