title: Angiotensin II receptor blockers in pregnancy: a case report and systematic review of the literature.
abstract: OBJECTIVE
  To describe the case of a woman exposed to angiotensin-II receptor blockers (ARBs) in the preconceptional period and to systematically review the literature on the safety of these drugs when used by pregnant women.
  
  
  METHODS
  The case was identified at the Korean Motherisk Program (Seoul). For the systematic review, we searched the PubMed for case reports, case series, and post-marketing surveys.
  
  
  RESULTS
  A hypertensive woman was exposed to irbesartan prior to conception. The embryo had delayed development of upper and lower extremities and decreased digital groove. A karyotype identified a 45,XO Turner syndrome. The patient had a spontaneous abortion. Including the case reported here, 64 published cases were identified in total; 57.8% had favorable and 42.2% had unfavorable outcomes. Duration of treatment during pregnancy among women who had adverse fetal outcomes was 26.3 +/- 10.5 weeks (mean +/- SD), compared with 17.3 +/- 11.6 weeks in those who had favorable outcomes (p = 0.04).
  
  
  CONCLUSIONS
  Exposure to ARBs for a period longer than the first trimester of pregnancy appears to be associated with a high risk for adverse fetal outcomes.
authors: PharmaREASONS. Toronto, Ontario, Canada.
authors: Elvia Yadira
authors: EY
authors: Velázquez-Armenta
authors: Jung Yeol
authors: JY
authors: Han
authors: June Seek
authors: JS
authors: Choi
authors: Kwang Moon
authors: KM
authors: Yang
authors: Alejandro A
authors: AA
authors: Nava-Ocampo
mesh_terms: D000022:Abortion, Spontaneous; D000328:Adult; D047228:Angiotensin II Type 1 Receptor Blockers / Q000009:adverse effects*; D001713:Biphenyl Compounds / Q000009:adverse effects*; D005260:Female; D006801:Humans; D000077405:Irbesartan; D047489:Preconception Injuries; D011247:Pregnancy; D011256:Pregnancy Outcome; D011297:Prenatal Exposure Delayed Effects / Q000139:chemically induced; D013777:Tetrazoles / Q000009:adverse effects*; D013997:Time Factors; D014424:Turner Syndrome / Q000139:chemically induced*
chemical_list: D047228:Angiotensin II Type 1 Receptor Blockers; D001713:Biphenyl Compounds; D013777:Tetrazoles; D000077405:Irbesartan