title: Systematic review of the depressive symptoms associated with vascular conditions.
abstract: BACKGROUND
  Numerous studies report a positive association between the presence of vascular conditions and depression; however, it is unclear whether this presents a distinct subtype of depression.
  
  
  METHODS
  A comprehensive literature search of Medline was conducted in order to identify studies that have compared symptoms of those with depression in the presence and absence of vascular factors.
  
  
  OBJECTIVE
  To provide a systematic review of studies that have attempted to characterise the depressive symptomatology associated with vascular factors. To establish whether the evidence for a subtype is sufficient to be of use in clinical settings.
  
  
  RESULTS
  Thirteen publications were identified as relevant to the investigation. Study design and definition of vascular factors varied greatly between studies. Depression in the presence of vascular conditions was associated with poor motivation, lack of energy and psychomotor change in some studies, though these findings were inconsistent. Many other possible distinctive features were reported in individual publications but were not consistent enough to be used confidently as a diagnostic feature.
  
  
  CONCLUSIONS
  At present, there does not appear to be sufficient evidence to support a clinically-recognisable subtype of vascular depression.
authors: Department of Public Health and Primary Care, University of Cambridge, UK. fm257@cam.ac.uk
authors: Fiona
authors: F
authors: McDougall
authors: Carol
authors: C
authors: Brayne
mesh_terms: D002561:Cerebrovascular Disorders / Q000453:epidemiology / Q000503:physiopathology / Q000523:psychology*; D003072:Cognition Disorders / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology; D003863:Depression / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D005221:Fatigue / Q000453:epidemiology / Q000209:etiology; D006801:Humans; D009042:Motivation; D015995:Prevalence; D011596:Psychomotor Disorders / Q000453:epidemiology / Q000209:etiology; D012720:Severity of Illness Index