Characterization of polysaccharide hydrogels for modified drug delivery.
Hydrogels are hydrophilic macromolecular networks that are capable of retaining a large amount of water. A precise description of these systems is actually quite complex and the practical use of hydrogels for drug delivery and biomedical applications is often not supported by a well-defined knowledge of the overall structure of the polymeric network. In this paper, we report the characterization of two different systems: a chemical network based on Guar Gum (GG) and a physical gel prepared with Xanthan (Xanth) and Locust Bean Gum (LBG). The dynamo-mechanical properties of the gels were analysed: the cohesiveness and the adhesion of the networks were strongly dependent on time, temperature, and composition. The kinetics of the chemical crosslinking was followed by means of rheological measurements, i.e. recording the mechanical spectra of the gelling system, and the power law exponent at the gel point was evaluated. Furthermore, the networks, loaded with model drugs with different steric hindrance, were used as matrices for tablets and the rate of release of such model drugs was studied. The diffusion of the guest molecules was deeply dependent on their dimensions; in the case of Xanth-LBG tablets the release profiles were almost independent from the different cohesion properties of the starting hydrogel composition.
Sandolo
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C
Faculty of Pharmacy, University of Rome La Sapienza, Piazzale A. Moro 5, Rome, Italy.
Coviello
T
T
Matricardi
P
P
Alhaique
F
F
D016503:Drug Delivery Systems; D005685:Galactans / Q000737:chemistry*; D020100:Hydrogels / Q000737:chemistry*; D008351:Mannans / Q000737:chemistry*; D053149:Plant Gums / Q000737:chemistry*; D011134:Polysaccharides / Q000737:chemistry*; D011135:Polysaccharides, Bacterial / Q000737:chemistry*; D013696:Temperature
D005685:Galactans; D020100:Hydrogels; D008351:Mannans; D053149:Plant Gums; D011134:Polysaccharides; D011135:Polysaccharides, Bacterial; C007894:guar gum; C002563:xanthan gum; C017471:locust bean gum