title: Discovery and development of therapeutic cancer vaccines.
abstract: Over the past century, various efforts have been made to induce the rejection of cancerous tissues by the stimulation of an immune reaction, using both non-specific and antigen-specific strategies. Non-specific approaches attempt to augment an immune response in and around the tumor by injecting immune stimulating substances, for example, bacterial extracts, cytokines or gene therapy agents. Antigen-specific approaches use either the tumor cells themselves as a source of antigens or incorporate identified tumor-associated antigens into vaccines. This review describes antigen-specific therapeutic cancer vaccines that are currently in development.
authors: Transgene SA, Department of Medical Affairs, 11 rue de Molsheim, 67082 Strasbourg, France. acres@transgene.fr
authors: Bruce
authors: B
authors: Acres
authors: Jean-Marc
authors: JM
authors: Limacher
authors: Jeanoy
authors: J
authors: Bonnefoy
mesh_terms: D000818:Animals; D019496:Cancer Vaccines / Q000627:therapeutic use*; D006801:Humans; D007167:Immunotherapy; D009369:Neoplasms / Q000276:immunology / Q000517:prevention & control* / Q000628:therapy*
chemical_list: D019496:Cancer Vaccines