title: Genetic analysis of two influenza A (H1) swine viruses isolated from humans in Thailand and the Philippines.
abstract: Influenza viruses A/Philippines/341/2004 (H1N2) and A/Thailand/271/2005 (H1N1) were isolated from two males, with mild influenza providing evidence of sporadic human infection by contemporary swine influenza. Both viruses were antigenically and genetically distinct from influenza A (H1N1 and H1N2) viruses that have circulated in the human population. Genetic analysis of the haemagglutinin genes found these viruses to have the highest degree of similarity to the classical swine H1 viruses circulating in Asia and North America. The neuraminidase gene and the internal genes were found to be more closely related to viruses circulating in European swine, which appear to have undergone multiple reassorting events. Although transmission of swine influenza to humans appears to be a relatively rare event, swine have been proposed as the intermediate host in the generation of potential pandemic influenza virus that may have the capacity to cause human epidemics resulting in high morbidity and mortality.
authors: WHO Collaborating Centre for Reference and Research on Influenza, 45 Poplar Rd, Parkville, VIC 3052, Australia. Naomi.Komadina@influenzacentre.org
authors: N
authors: N
authors: Komadina
authors: V
authors: V
authors: Roque
authors: P
authors: P
authors: Thawatsupha
authors: J
authors: J
authors: Rimando-Magalong
authors: S
authors: S
authors: Waicharoen
authors: E
authors: E
authors: Bomasang
authors: P
authors: P
authors: Sawanpanyalert
authors: M
authors: M
authors: Rivera
authors: P
authors: P
authors: Iannello
authors: A C
authors: AC
authors: Hurt
authors: I G
authors: IG
authors: Barr
mesh_terms: D000328:Adult; D000818:Animals; D002675:Child, Preschool; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000235:genetics*; D007251:Influenza, Human / Q000453:epidemiology / Q000821:virology*; D008297:Male; D008969:Molecular Sequence Data; D010679:Philippines / Q000453:epidemiology; D010802:Phylogeny; D016865:Reassortant Viruses / Q000235:genetics; D013552:Swine / Q000821:virology*; D013785:Thailand / Q000453:epidemiology