title: Daily profile of circulating C-type natriuretic peptide in pre-ascitic cirrhosis and in normal subjects: relationship with renal function.
abstract: OBJECTIVE
  To investigate whether the C-type natriuretic peptide (CNP) has a role in the regulation of fluid and sodium homeostasis in normal subjects and in pre-ascitic cirrhotic patients.
  
  
  METHODS
  The daily profile of CNP plasma levels was assessed by serial measurements (0700 h, 0900 h, 1800 h, 2300 h) in 10 pre-ascitic cirrhotic outpatients (age 56+/-4 years) and in 10 age-matched healthy controls (54+/-2 years) on a normal sodium diet (150 mmol/day) while carrying on their usual activities (mobile from 0700 h to 2200 h), after an equilibration period of 5 days. Daily diuresis and natriuresis were also monitored.
  
  
  RESULTS
  Mean daily CNP was comparable in cirrhotic and healthy subjects (3.64+/-0.32 versus 3.20+/-0.20 pg/ml; p=0.139); CNP concentration showed a tendency towards a circadian fluctuation in healthy subjects (p=0.053) but not in patients (p=0.171). Mean daily CNP concentration significantly correlated with 24-h natriuresis (r=0.709; p=0.022) and urine volume (r=0.745; p=0.013) in patients but not in healthy subjects.
  
  
  CONCLUSIONS
  CNP plasma levels appear to play a role in the water-sodium balance regulation in patients with pre-ascitic cirrhosis.
authors: Dipartimento di Medicina Interna, Cardioangiologia ed Epatologia, Alma Mater Studiorum, Università di Bologna, Italy.
authors: Andrea
authors: A
authors: Zambruni
authors: Franco
authors: F
authors: Trevisani
authors: Veit
authors: V
authors: Gülberg
authors: Paolo
authors: P
authors: Caraceni
authors: Marco
authors: M
authors: Domenicali
authors: Maria Chiara
authors: MC
authors: Cantarini
authors: Federica Mirici
authors: FM
authors: Cappa
authors: Antonio
authors: A
authors: Di Micoli
authors: Giulia
authors: G
authors: Magini
authors: Antonio Maria
authors: AM
authors: Labate-Morselli
authors: Alexander L
authors: AL
authors: Gerbes
authors: Mauro
authors: M
authors: Bernardi
mesh_terms: D001201:Ascites / Q000097:blood / Q000209:etiology*; D002940:Circadian Rhythm / Q000502:physiology*; D018450:Disease Progression; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate / Q000502:physiology; D006801:Humans; D007668:Kidney / Q000503:physiopathology*; D008103:Liver Cirrhosis / Q000097:blood* / Q000150:complications; D008875:Middle Aged; D009318:Natriuresis / Q000502:physiology*; D020098:Natriuretic Peptide, C-Type / Q000097:blood*; D012720:Severity of Illness Index
chemical_list: D020098:Natriuretic Peptide, C-Type