Paradoxical effect of Echinocandins across Candida species in vitro: evidence for echinocandin-specific and candida species-related differences.
Paradoxical growth of some Candida isolates occurs at concentrations above the MIC for echinocandins. In 60 Candida bloodstream isolates from cancer patients (20 C. albicans isolates and 10 isolates each of C. parapsilosis, C. tropicalis, C. krusei, and C. glabrata), paradoxical growth was more frequent with caspofungin than micafungin or anidulafungin, was unrelated to MIC, and was strikingly absent in C. glabrata isolates.
Chamilos
Georgios
G
Department of Infectious Diseases, Infection Control and Employee Health, Unit 402, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.
Lewis
Russell E
RE
Albert
Nathaniel
N
Kontoyiannis
Dimitrios P
DP
D000935:Antifungal Agents / Q000145:classification / Q000494:pharmacology; D002175:Candida / Q000145:classification / Q000187:drug effects / Q000254:growth & development / Q000302:isolation & purification; D002177:Candidiasis / Q000382:microbiology; D003470:Culture Media; D016469:Fungemia / Q000382:microbiology; D006801:Humans; D008826:Microbial Sensitivity Tests / Q000379:methods; D009369:Neoplasms / Q000150:complications; D010456:Peptides, Cyclic / Q000145:classification / Q000494:pharmacology; D013045:Species Specificity
D000935:Antifungal Agents; D003470:Culture Media; D010456:Peptides, Cyclic