Preparation of guanine and diaminopurine from biuret. Part III.
Because of their potential prebiotic origin and relative chemical stability, urea, biuret, formic acid, and glycine amide might have played a role in the assembly process of purine bases. In this paper, we describe a short reaction path to purine nucleobases from these acyclic precursors. The formation of different purines was verified by UV and NMR spectroscopy, as well as by mass spectrometry.
Lagoja
Irene M
IM
Laboratory of Medicinal Chemistry, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000 Leuven. irene.lagoja@rega.kuleuven.be
Herdewijn
Piet
P
D000577:Amides / Q000737:chemistry; D001737:Biuret / Q000737:chemistry*; D002855:Chromatography, Thin Layer; D005998:Glycine / Q000031:analogs & derivatives / Q000737:chemistry; D006147:Guanine / Q000737:chemistry / Q000302:isolation & purification*; D007202:Indicators and Reagents; D007536:Isomerism; D009930:Organic Chemicals / Q000737:chemistry; D011687:Purines / Q000138:chemical synthesis* / Q000737:chemistry / Q000302:isolation & purification; D014508:Urea / Q000031:analogs & derivatives
D000577:Amides; D007202:Indicators and Reagents; C516965:N,N'-diformylurea; D009930:Organic Chemicals; D011687:Purines; C018556:glycine amide; D006147:Guanine; D001737:Biuret; D014508:Urea; D005998:Glycine