title: Malaria-infected mice are cured by a single dose of novel artemisinin derivatives.
abstract: We disclose here for the first time the curative activity of a new generation of trioxane dimers, designed logically and prepared easily from the natural trioxane artemisinin in only four or five chemical steps that would be easily accomplished also on a manufacturing scale. Four of these trioxane dimers cure malaria-infected mice after only a single subcutaneous dose, and two other dimers cure after three oral doses.
authors: Department of Chemistry, School of Arts and Sciences, The Johns Hopkins Malaria Research Institute, Johns Hopkins University, Baltimore, Maryland 21218, USA. ghp@jhu.edu
authors: Gary H
authors: GH
authors: Posner
authors: Ik-Hyeon
authors: IH
authors: Paik
authors: Wonsuk
authors: W
authors: Chang
authors: Kristina
authors: K
authors: Borstnik
authors: Sandra
authors: S
authors: Sinishtaj
authors: Andrew S
authors: AS
authors: Rosenthal
authors: Theresa A
authors: TA
authors: Shapiro
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D037621:Artemisinins / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D008288:Malaria / Q000188:drug therapy* / Q000401:mortality; D051379:Mice; D010962:Plasmodium berghei; D013329:Structure-Activity Relationship
chemical_list: D000962:Antimalarials; D037621:Artemisinins; D019086:Bridged Bicyclo Compounds, Heterocyclic