title: Comparison of the mucosal immune response in dogs vaccinated with either an intranasal avirulent live culture or a subcutaneous antigen extract vaccine of Bordetella bronchiseptica.
abstract: Healthy dogs with low antibody titer to Bordetella bronchiseptica were vaccinated intranasally with an avirulent live vaccine, subcutaneously with an antigen extract vaccine, or subcutaneously and intranasally with a placebo. Intranasally vaccinated dogs developed B. bronchiseptica-specific IgA titers in nasal secretions that remained at high levels until the end of the study; dogs vaccinated subcutaneously with the antigen extract or placebo did not develop measurable antigen-specific IgA titers in nasal secretions. Dogs were challenged with virulent live B. bronchiseptica 63 days after vaccination. Intranasally vaccinated dogs had significantly lower cough scores (P < or =.0058) and shed significantly fewer challenge organisms (P <.0001) than dogs in either of the other groups. Cough scores of subcutaneously vaccinated dogs were not significantly different from placebo-vaccinated dogs.
authors: Schering Plough Animal Health, 21401 West Center Road, Elkhorn, NE 68022, USA.
authors: Randy
authors: R
authors: Davis
authors: Huchappa
authors: H
authors: Jayappa
authors: Omar Y
authors: OY
authors: Abdelmagid
authors: Rob
authors: R
authors: Armstrong
authors: Diane
authors: D
authors: Sweeney
authors: Craig
authors: C
authors: Lehr
mesh_terms: D000281:Administration, Intranasal; D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood; D000942:Antigens, Bacterial / Q000276:immunology*; D001428:Bacterial Vaccines / Q000008:administration & dosage / Q000627:therapeutic use*; D001885:Bordetella Infections / Q000517:prevention & control / Q000662:veterinary*; D016950:Bordetella bronchiseptica / Q000276:immunology*; D001991:Bronchitis / Q000517:prevention & control / Q000662:veterinary*; D004283:Dog Diseases / Q000276:immunology / Q000517:prevention & control*; D004285:Dogs; D007070:Immunoglobulin A / Q000378:metabolism; D007279:Injections, Subcutaneous / Q000662:veterinary; D009297:Nasal Mucosa / Q000276:immunology; D016896:Treatment Outcome; D014611:Vaccination / Q000662:veterinary
chemical_list: D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D001428:Bacterial Vaccines; D007070:Immunoglobulin A