title: Hypercalciuria in pediatric patients with ureteropelvic junction obstruction is of genetic origin.
abstract: OBJECTIVE
  Genitourinary tract malformations are associated with urolithiasis. Hypercalciuria has been described in children with ureteropelvic junction obstruction (UPJO), although the etiology of this metabolic abnormality remains unknown. This study was conducted to find out whether children with UPJO have a higher prevalence of hypercalciuria and whether their family members are affected by hypercalciuria and/or urolithiasis.
  
  
  METHODS
  We studied the prevalence of hypercalciuria and urolithiasis in 27 children (14 males, 13 females) with UPJO and their parents.
  
  
  RESULTS
  One patient had a history of renal colic, whereas imaging studies showed macroscopic renal lithiasis in two patients and calyceal microlithiasis in four. Hypercalciuria was found in 17/27 children (63%), 15 of whom (88%) had a familial history of urolithiasis: seven families in first-degree relatives, six in second-degree relatives and two in other relatives. Concerning the 10 children without hypercalciuria, seven of them (70%) had a family history of urolithiasis: four in first-degree relatives and three in second-degree relatives. The prevalences of both urolithiasis and hypercalciuria were not influenced by gender.
  
  
  CONCLUSIONS
  Urolithiasis is associated with hypercalciuria in patients with UPJO. In accordance with previous data, our results show that the prevalence of hypercalciuria is greater in pediatric patients with UPJO than in the general population. Likewise, the prevalence of urolithiasis in the families of these children is also higher than that in the general population. Hypercalciuria was inherited as an autosomal dominant trait.
authors: Pediatric Nephrology Unit, Nuestra Señora de Candelaria University Hospital, Santa Cruz de Tenerife, Spain. vgarcia@comtf.es
authors: Víctor
authors: V
authors: García-Nieto
authors: Juan F
authors: JF
authors: Navarro
authors: Ma Isabel
authors: MI
authors: Luis-Yanes
authors: Marisela
authors: M
authors: López-Méndez
authors: Victoria
authors: V
authors: García-Rodríguez
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D053565:Hypercalciuria / Q000453:epidemiology / Q000209:etiology*; D007223:Infant; D007231:Infant, Newborn; D007682:Kidney Pelvis; D008297:Male; D015995:Prevalence; D014517:Ureteral Obstruction / Q000150:complications* / Q000235:genetics*