[Neonatal sepsis in the era of antenatal antibiotic prophylaxis].
The aim of this study was to compare incidence, bacteriology and associated mortality of neonatal sepsis in a neonatal unit, after (2001-2004) and before (1995-1996) implementation of universal screening for prevention of Group B Streptococcus diseases. Early onset sepsis incidence decreased from 2.5 to 1 per 1000 live births (p=0.03), with a decrease in the proportion of Group B Streptococcus cases from a 54% to 11% (p<0.01). In late onset sepsis, coagulase-negative Staphylococci continued to be the predominant pathogen (49% of cases), and Candida albicans emerged as the second etiologic agent in the postscreening period. Sepsis associated mortality was low in both periods (2.2%).
Tapia I
José Luis
JL
Unidad de Neonatología, Departamento de Pediatría, Hospital Clínico, Pontificia Universidad Católica de Chile, Santiago, Chile. jlta@med.puc.cl
Reichhard T
Cristina
C
Saldías R
M Isabel
MI
Abarzúa C
Fernando
F
Pérez A
M Eugenia
ME
González M
Alvaro
A
Gederlini G
Alessandra
A
D019072:Antibiotic Prophylaxis; D002677:Chile / Q000453:epidemiology; D005260:Female; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control* / Q000706:statistics & numerical data; D007363:Intensive Care Units, Neonatal / Q000706:statistics & numerical data*; D008297:Male; D018805:Sepsis / Q000382:microbiology / Q000401:mortality / Q000517:prevention & control*