title: alpha-Glucosidase inhibitory constituents from stem bark of Terminalia superba (Combretaceae).
abstract: The CH(2)Cl(2)/CH(3)OH (1/1) extract of the dried stem bark of Terminalia superba afforded two compounds, (7S,8R,7'R,8'S)-4'-hydroxy-4-methoxy-7,7'-epoxylignan and meso-(rel 7S,8R,7'R,8'S)-4,4'-dimethoxy-7,7'-epoxylignan along with 11 known compounds. The structures of the compounds were established by analysing the spectroscopic data and also comparing it with the data of previously known analogues. All the isolated compounds were evaluated for their glycosidase inhibition activities. Gallic acid and methyl gallate showed significant alpha-glucosidase inhibition activity.
authors: Department of Chemistry, University of Douala, Faculty of Science, P.O. Box 24157, Douala, Cameroon. jdwansi@yahoo.fr
authors: Jean Duplex
authors: JD
authors: Wansi
authors: Marie-Christine
authors: MC
authors: Lallemand
authors: David Daco
authors: DD
authors: Chiozem
authors: Flavien Aristide A
authors: FA
authors: Toze
authors: Luc Meva'a
authors: LM
authors: Mbaze
authors: Shamsun
authors: S
authors: Naharkhan
authors: Muhammad Choudhary
authors: MC
authors: Iqbal
authors: François
authors: F
authors: Tillequin
authors: Jean
authors: J
authors: Wandji
authors: Zacharias Tanee
authors: ZT
authors: Fomum
mesh_terms: D004791:Enzyme Inhibitors / Q000302:isolation & purification / Q000494:pharmacology; D065089:Glycoside Hydrolase Inhibitors; D017705:Lignans / Q000302:isolation & purification / Q000494:pharmacology; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology; D018547:Plant Stems / Q000737:chemistry; D029766:Terminalia / Q000737:chemistry*
chemical_list: D004791:Enzyme Inhibitors; D065089:Glycoside Hydrolase Inhibitors; D017705:Lignans; D010936:Plant Extracts