Targeting Bcl-X(L) for prevention and therapy of skin cancer.
Apoptosis plays an important role in skin carcinogenesis. Bcl-X(L), an antiapoptotic Bcl-2 family member, is a key regulator in the process. Aberrant expression of Bcl-X(L) allows cells carrying mutations to survive and propagate. Overexpression of Bcl-X(L) is correlated with tumor malignancy and invasion. Importantly, deregulation of Bcl-X(L) confers drug resistance to chemotherapy. Therefore, targeting Bcl-X(L) in combination with conventional chemotherapy is a promising way to pursue cancer chemotherapy. Several compounds targeting Bcl-X(L) expression or function have shown their potential in chemoprevention and of chemotherapy of cancer.
Zhang
Jack
J
Arizona Cancer Center, University of Arizona, 1515 N. Campbell, Tucson, Arizona 85724, USA.
Bowden
G Tim
GT
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D017209:Apoptosis / Q000187:drug effects*; D006801:Humans; D012878:Skin Neoplasms / Q000188:drug therapy / Q000378:metabolism / Q000517:prevention & control*; D051020:bcl-X Protein / Q000037:antagonists & inhibitors* / Q000378:metabolism
D000970:Antineoplastic Agents; D051020:bcl-X Protein