title: Tumor-volume increase at beginning of primary treatment with topical interferon alpha 2-beta in a case of conjunctiva-cornea intraepithelial neoplasia.
abstract: OBJECTIVE
  The aim of this study was to report on the effectiveness and tumor side effects of topical interferon (INF) alpha 2-beta in a case of conjunctiva-cornea intraepithelial neoplasia (CIN) of a patient that rejected any surgical procedure.
  
  
  METHODS
  This study is a case report description.
  
  
  RESULTS
  An 81-year-old man with a history of neoplasies of the colon and prostate and anticoagulant treatment was referred for treatment of an ocular surface neoplasia on his left eye. Pathognomonic signs of CIN were present. The patient rejected surgical procedures. A regimen of topical INF alpha 2-beta 4 times daily was administered. An increase in tumor volume of 25% was observable 15 days after the beginning of therapy. No subjective discomfort was reported. The treatment continued with follow-ups every 15 days. The progressive regression was remarkable. Complete regression of the CIN was observable after 60 days of therapy. No other side-effects were detected.
  
  
  CONCLUSIONS
  Topical INF alpha 2-beta is a valid choice for the treatment of CIN in patients for whom surgery is not possible. The increase of tumor volume at the beginning of therapy does not require the suspension of treatment.
authors: Department of Ophthalmology, University Hospital Arnau de Vilanova, Lleida, Spain. vhuerva@mixmail.com
authors: Valentín
authors: V
authors: Huerva
authors: Maria Carmen
authors: MC
authors: Sánchez
authors: Irene
authors: I
authors: Mangues
mesh_terms: D000287:Administration, Topical; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D002278:Carcinoma in Situ / Q000188:drug therapy*; D003230:Conjunctival Neoplasms / Q000188:drug therapy*; D003316:Corneal Diseases / Q000188:drug therapy*; D005134:Eye Neoplasms / Q000188:drug therapy; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D009883:Ophthalmic Solutions; D011994:Recombinant Proteins; D012074:Remission Induction; D047368:Tumor Burden / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D009883:Ophthalmic Solutions; D011994:Recombinant Proteins