title: Antibiotic susceptibilities of bacteria isolated from ophthalmic specimens between 1984 and 2005 in Zurich, Switzerland.
abstract: BACKGROUND
  Increasing resistance of bacteria cultured from ophthalmic specimens to antibiotic therapy has been documented worldwide. Inappropriate prescribing practices are thought to represent a major risk factor for antibiotic resistance. This study investigates the pattern of bacterial antibiotic susceptibility in Zurich, Switzerland over a period of twenty years.
  
  
  METHODS
  Antibiotic susceptibilities of bacterial isolates from all ophthalmic specimens cultured at the Institute of Medical Microbiology in Zurich between 1984 and 2005 were analysed retrospectively.
  
  
  RESULTS
  A total of 7,862 ocular surface samples have been collected. 3,010 specimens (38.3 %) were positive for aerobic bacteria. The strains isolated most frequently were Staphylococcus aureus (23.9 %), coagulase-negative staphylococci (16.1 %), Pseudomonas aeruginosa (10.0 %), Haemophilus influenzae (6.3 %), Escherichia coli (5.1 %), Serratia marcescens (4.7 %), and Streptococcus pneumoniae (3.9 %). Various bacteria accounted for the remaining 30.0 %. Susceptibility of these strains to the aminoglycosides, quinolones, and cephalosporins tested did not change over this period of time.
  
  
  CONCLUSIONS
  The data suggest that bacteria cultured from ophthalmic specimens in Zurich, Switzerland have not changed their pattern of antibiotic susceptibility over the past 20 years.
authors: Department of Ophthalmology, University of Zurich, Zurich, Switzerland.
authors: P P
authors: PP
authors: Maurer
authors: R
authors: R
authors: Zbinden
authors: C
authors: C
authors: Kaufmann
authors: M A
authors: MA
authors: Thiel
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D003231:Conjunctivitis / Q000453:epidemiology* / Q000382:microbiology*; D004351:Drug Resistance; D015818:Eye Infections, Bacterial / Q000453:epidemiology* / Q000382:microbiology*; D006801:Humans; D008826:Microbial Sensitivity Tests / Q000706:statistics & numerical data; D013557:Switzerland / Q000453:epidemiology
chemical_list: D000900:Anti-Bacterial Agents