Allogenous bone grafts improved by bone marrow stem cells and platelet growth factors: clinical case reports.
In order to increase the amount of available bone where dental implants must be placed, the present study has associated platelet-rich plasma (PRP) and mononuclear cells (MNCs) from bone marrow aspirate and bone scaffold (BS) in 32 patients aged between 45 and 75 years old. The MNC attainment and the adherence to the BS were confirmed through histology, cell culture, and scanning electron microscopy. The clinical results, analyzed by computed tomography, have showed that the scaffolds were well integrated and adapted to the cortical bone. We can conclude that the process of healing observed in the patients was due to the presence of mesenchymal stem cell in MNC fraction in the bone grafts.
Filho Cerruti
Humberto
H
Clínica CERA LTDA, University of São Paulo Medical School, São Paulo, Brazil.
Kerkis
Irina
I
Kerkis
Alexandre
A
Tatsui
Nelson Hidekazu
NH
da Costa Neves
Adriana
A
Bueno
Daniela Franco
DF
da Silva
Marcelo Cavenaghi Pereira
MC
D000368:Aged; D000369:Aged, 80 and over; D001861:Bone Regeneration; D016025:Bone Transplantation / Q000379:methods*; D015921:Dental Implants; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000637:transplantation / Q000648:ultrastructure; D008297:Male; D008437:Maxilla / Q000000981:diagnostic imaging / Q000601:surgery; D008855:Microscopy, Electron, Scanning; D008875:Middle Aged; D016348:Osseointegration; D053657:Platelet-Rich Plasma / Q000502:physiology*; D023822:Tissue Engineering; D014057:Tomography, X-Ray Computed; D014184:Transplantation, Homologous
D015921:Dental Implants