title: Feasibility and outcome of reduced-intensity conditioning in haploidentical transplantation.
abstract: Allogeneic stem cell transplantation is for a number of patients with malignant and nonmalignant diseases the only curative approach. For those patients who do not have an HLA-identical-related or -unrelated stem cell donor, a related three-loci mismatch haploidentical stem cell transplantation with T cell-depleted stem cells is a viable option. T cell depletion either by CD34(+) positive selection or by CD3-negative depletion strategies is available and has been investigated. We have shown that reduced-intensity conditioning haploidentical transplantation using mobilized peripheral stem cells negatively depleted from T and B lymphocytes is associated with a rapid immune reconstitution, a low transplant-related mortality rate, and a favorable outcome in patients in remission at the time of transplant. For chemorefractory patients, additional posttransplant cellular and humoral immunotherapeutic strategies are needed for prevention of relapse after transplantation.
authors: Children's University Hospital, University of Tuebingen, Hoppe-Seyler-Strasse 1, 72076 Tuebingen, Germany. Rupert.Handgretinger@med.uni-tuebingen.de
authors: Rupert
authors: R
authors: Handgretinger
authors: Xiaohua
authors: X
authors: Chen
authors: Matthias
authors: M
authors: Pfeiffer
authors: Ingo
authors: I
authors: Mueller
authors: Tobias
authors: T
authors: Feuchtinger
authors: Gregory A
authors: GA
authors: Hale
authors: Peter
authors: P
authors: Lang
mesh_terms: D018952:Antigens, CD34 / Q000096:biosynthesis; D001402:B-Lymphocytes / Q000378:metabolism; D017252:CD3 Complex / Q000096:biosynthesis; D005240:Feasibility Studies; D006085:Graft Survival; D006086:Graft vs Host Disease; D006680:HLA Antigens / Q000737:chemistry*; D006650:Histocompatibility Testing / Q000379:methods; D006801:Humans; D007107:Immune System; D012008:Recurrence; D033581:Stem Cell Transplantation / Q000379:methods*; D013601:T-Lymphocytes / Q000378:metabolism; D019172:Transplantation Conditioning; D014184:Transplantation, Homologous / Q000379:methods*
chemical_list: D018952:Antigens, CD34; D017252:CD3 Complex; D006680:HLA Antigens