Central auditory development: evidence from CAEP measurements in children fit with cochlear implants.
In normal-hearing children the latency of the P1 component of the cortical evoked response to sound varies as a function of age and, thus, can be used as a biomarker for maturation of central auditory pathways. We assessed P1 latency in 245 congenitally deaf children fit with cochlear implants following various periods of auditory deprivation. If children experience less than 3.5 years of auditory deprivation before implantation, P1 latencies fall into the range of normal following 3-6 months of electrical stimulation. Children who experience greater than 7 years of deprivation, however, generally do not develop normal P1 latencies even after years of stimulation. Moreover, the waveforms for these patients can be markedly abnormal. Cortical reorganization stimulated by deprivation is likely to be a significant factor in both variation in the latency and morphology of the cortical evoked response to sound for children fit with a cochlear implant and variation in the development of oral speech and language function.


OBJECTIVE
The reader will be introduced to research using cortical evoked responses (CAEPs), positron emission tomography (PET) scans and in-depth recording from the auditory cortex of congenitally deaf cats that converges on the existence of a sensitive period for the development of central auditory pathways in children. The reader will also be provided with two case studies that illustrate the use of the P1 response as biomarker for development of central auditory pathways. Finally, suggestions for future research will be provided.
Dorman
Michael F
MF
Department of Speech and Hearing Science, Arizona State University, AZ, USA. mdorman@asu.edu
Sharma
Anu
A
Gilley
Phillip
P
Martin
Kathryn
K
Roland
Peter
P
D001303:Auditory Cortex / Q000000981:diagnostic imaging; D001304:Auditory Diseases, Central / Q000175:diagnosis* / Q000601:surgery*; D001306:Auditory Pathways / Q000503:physiopathology; D002648:Child; D002675:Child, Preschool; D019929:Cochlear Implantation / Q000379:methods*; D005072:Evoked Potentials, Auditory / Q000502:physiology; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D049268:Positron-Emission Tomography; D012720:Severity of Illness Index