[Progress in metabolism and crucial enzymes of glycerol conversion to 1,3-propanediol].
1,3-propanediol production by microbial fermentation has become the research hot spot for its amiability with the environment. Here the molecular mechanism of glycerol bioconversion to 1,3-propanediol was outlined by elucidating the fermentation strains, metabolic pathways, regulon and key enzymes. Of enzymes, glycerol dehydrogenase, the velocity-limiting enzyme in glycerol reductive pathway, was emphatically discussed with regard to its molecular structure and reactivating factors. This paper aims to provide the basis for genetic modification of fermentation strains.
Tian
Ping-Fang
PF
College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China.
Tan
Tian-Wei
TW
D001419:Bacteria / Q000201:enzymology / Q000235:genetics / Q000378:metabolism; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D053898:Biosynthetic Pathways; D005285:Fermentation; D023061:Gene Order; D005990:Glycerol / Q000378:metabolism*; D006836:Hydro-Lyases / Q000235:genetics / Q000378:metabolism*; D007218:Industrial Microbiology / Q000379:methods / Q000639:trends; D011409:Propylene Glycols / Q000378:metabolism*; D013401:Sugar Alcohol Dehydrogenases / Q000235:genetics / Q000378:metabolism*
D001426:Bacterial Proteins; D011409:Propylene Glycols; C041787:1,3-propanediol; D013401:Sugar Alcohol Dehydrogenases; C020672:glycerol dehydrogenase; D006836:Hydro-Lyases; C020671:glycerol dehydratase; D005990:Glycerol