title: Alleviation of oxidative and nitrosative stress following curative resection in patient with oral cavity cancer.
abstract: BACKGROUND
  Oxidative stress by reactive oxygen species (ROS) and nitrosative stress by reactive nitrogen species (RNS) are proven initiators and promoters in carcinogenesis. Elevated ROS/RNS with lowered antioxidants occur in patients with squamous cell carcinoma of oral cavity. Ours is the first study to evaluate the effect of curative resection on both oxidative and nitrosative stress in such patients.
  
  
  METHODS
  This study was conducted on 24 cancer patients and with age- and sex-matched healthy controls. Lipid peroxidation products, nitric oxide (NO) products and ceruloplasmin (CPL) in plasma were measured before and after surgery. Similarly enzymatic antioxidants in erythrocytes and non-enzymatic antioxidants in plasma were measured.
  
  
  RESULTS
  Statistically significant elevation of lipid peroxidation, NO products and CPL and depletion of antioxidants were found in cancer patients compared with controls. After curative surgical resection there was a statistically significant fall in oxidants and CPL coupled with a rise in antioxidants.
  
  
  CONCLUSIONS
  Our results suggest that oxidative/nitrosative stress could play a significant role in oral cavity cancer (OCC) and that curative resection is effective in alleviating this oxidative/nitrosative burden. Significant mitigation of oxidative/nitrosative stress could indicate the completeness of resection since tumor forms the major source of oxidants.
authors: Department of Surgery, Maryborough Base Hospital, Maryborough, Queensland, Australia.
authors: Muzib Hassanal
authors: MH
authors: Rasheed
authors: Syed Sultan
authors: SS
authors: Beevi
authors: R
authors: R
authors: Rajaraman
authors: S J C
authors: SJ
authors: Bose
mesh_terms: D000328:Adult; D001205:Ascorbic Acid / Q000097:blood; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000601:surgery*; D016022:Case-Control Studies; D005260:Female; D005978:Glutathione / Q000097:blood; D005982:Glutathione Transferase / Q000097:blood; D006801:Humans; D015227:Lipid Peroxidation; D008054:Lipid Peroxides / Q000097:blood; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000473:pathology / Q000601:surgery*; D009566:Nitrates / Q000097:blood; D009569:Nitric Oxide / Q000097:blood; D009573:Nitrites / Q000097:blood; D018384:Oxidative Stress; D010088:Oxidoreductases / Q000097:blood; D011300:Preoperative Care; D011446:Prospective Studies; D014810:Vitamin E / Q000097:blood
chemical_list: D008054:Lipid Peroxides; D009566:Nitrates; D009573:Nitrites; D014810:Vitamin E; D009569:Nitric Oxide; D008315:Malondialdehyde; D010088:Oxidoreductases; D005982:Glutathione Transferase; D005978:Glutathione; D001205:Ascorbic Acid