S-allyl cysteine prevents CCl(4)-induced acute liver injury in rats.
Aged garlic extract (AGE) possesses multiple biological activities. We evaluated the protective effect of S-allyl cysteine (SAC), one of the organosulfur compounds of AGE, against carbon tetrachloride (CCl(4))-induced acute liver injury in rats. SAC was administrated intraperitoneally (50-200 mg/kg). SAC significantly suppressed the increases of plasma ALT and LDH levels. SAC also attenuated histological liver damage. CCl(4) administration induced lipid peroxidation accompanied by increases in the plasma malondialdehyde and hepatic 4-hydroxy-2-nonenal levels, and SAC dose-dependently attenuated these increases. The hepatic total level of hydroxyoctadecadienoic acid (HODE), a new oxidative stress biomarker, was closely correlated with the amount of liver damage. These results suggest that SAC decreased CCl(4)-induced liver injury by attenuation of oxidative stress, and may be a better therapeutic tool for chronic liver disease.
Kodai
Shintaro
S
Department of Hepato-Biliary-Pancreatic Surgery, Graduate School of Medicine, Osaka City University, Osaka, Japan. s-kodai@med.osaka-cu.ac.jp
Takemura
Shigekazu
S
Minamiyama
Yukiko
Y
Hai
Seikan
S
Yamamoto
Satoshi
S
Kubo
Shoji
S
Yoshida
Yasukazu
Y
Niki
Etsuo
E
Okada
Shigeru
S
Hirohashi
Kazuhiro
K
Suehiro
Shigefumi
S
D000818:Animals; D015415:Biomarkers; D002251:Carbon Tetrachloride / Q000633:toxicity*; D003545:Cysteine / Q000031:analogs & derivatives* / Q000494:pharmacology; D005231:Fatty Acids, Unsaturated / Q000737:chemistry; D005737:Garlic / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism; D015227:Lipid Peroxidation; D008054:Lipid Peroxides / Q000737:chemistry; D008099:Liver / Q000293:injuries* / Q000473:pathology*; D008297:Male; D009504:Neutrophils / Q000378:metabolism; D018384:Oxidative Stress; D051381:Rats; D017208:Rats, Wistar
D015415:Biomarkers; D005231:Fatty Acids, Unsaturated; D008054:Lipid Peroxides; C495366:hydroxyoctadecadienoic acid; C065299:S-allylcysteine; D002251:Carbon Tetrachloride; D005978:Glutathione; D003545:Cysteine