title: The selective effect of N-feruloylserotonins isolated from Leuzea carthamoides on nociception and anxiety in rats.
abstract: The effects of N-feruloylserotonins, substances isolated from the seeds of Leuzea carthamoides (WILLD.) DC., on nociception and anxiety were studied in Wistar rats. Nociceptive responses were measured using the plantar and tail-flick tests which were administered before and after swimming stress (3 min, water temperature 32 degrees C). Anxiety was evaluated using an elevated plus maze. In Experiment I, neither basal nociception nor stress-induced analgesia was influenced significantly. Separating the animals into groups based on their basal nociceptive sensitivity, either high- or low-pain threshold revealed that N-feruloylserotonins have selective effects, especially on rats with high-pain thresholds. In these animals, N-feruloylserotonins reduced the stress-induced analgesia that followed swimming stress. In Experiment II, basal nociceptive sensitivity correlated with indicators of anxiety; high-pain threshold rats were more anxious in the elevated plus maze, with less frequent visits to open arms. The opposite effect was seen in low-pain threshold rats. N-feruloylserotonins did not influence anxiety in low-pain threshold rats, although it reduced anxiety in the high-pain threshold rats as indicated by the increased ratio of open arm visit frequency compared to closed arm visit frequency in the elevated plus maze. From these results we concluded that N-feruloylserotonins have selective stress-reducing effects in stress-sensitive animals.
authors: Charles University, 3rd Faculty of Medicine, Department of Normal, Pathological and Clinical Physiology, Ke Karlovu 4, 120 00 Prague, Czech Republic. yamamoto@lf3.cuni.cz
authors: A
authors: A
authors: Yamamotová
authors: M
authors: M
authors: Pometlová
authors: J
authors: J
authors: Harmatha
authors: H
authors: H
authors: Rasková
authors: R
authors: R
authors: Rokyta
mesh_terms: D000700:Analgesics; D000818:Animals; D014151:Anti-Anxiety Agents; D043843:Leuzea / Q000737:chemistry*; D008297:Male; D010147:Pain Measurement / Q000187:drug effects; D017288:Pain Threshold / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time / Q000187:drug effects; D012701:Serotonin / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D013315:Stress, Psychological / Q000523:psychology; D013550:Swimming / Q000523:psychology
chemical_list: D000700:Analgesics; D014151:Anti-Anxiety Agents; C512561:N-feruloylserotonin; D012701:Serotonin