Aurantiomides A-C, quinazoline alkaloids from the sponge-derived fungus Penicillium aurantiogriseum SP0-19.
Three new quinazoline alkaloids, aurantiomides A (1), B (2), and C (3), along with the known metabolite anacine (4) were isolated from the sponge-derived fungus strain Penicillium aurantiogriseum SP0-19 by bioassay-guided fractionation. Their structures were elucidated by spectroscopic and chemical methods. Their absolute configurations were deduced by comparison of their Cotton effects with anacine (4) and by chemical transformations. Compounds 2 and 3 showed moderate cytotoxicities against HL-60, P388 and BEL-7402, P388 cell lines, respectively.
Xin
Zhi Hong
ZH
Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People's Republic of China.
Fang
Yuchun
Y
Du
Lin
L
Zhu
Tianjiao
T
Duan
Lin
L
Chen
Juan
J
Gu
Qian-Qun
QQ
Zhu
Wei-Ming
WM
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification*; D000818:Animals; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007941:Leukemia P388; D051379:Mice; D015394:Molecular Structure; D010407:Penicillium / Q000737:chemistry*; D011161:Porifera / Q000382:microbiology; D011799:Quinazolines / Q000737:chemistry / Q000302:isolation & purification*
D000470:Alkaloids; D011799:Quinazolines; C521029:aurantiomide A; C521030:aurantiomide B; C521031:aurantiomide C