[The co-infection with hepatitis virus B and D--cases admitted in the infectious diseases hospital from Iaşi, Romania (2003-2005)].
Despite the major medical advance, over 350 million people worldwide still have chronic infection with hepatitis B virus and HBV-associated liver disease remains a major cause of morbidity and mortality. 15-50% of patient VHB infected have serological markers for VHD co-infection. We retrospectively studied 252 cases of acute hepatitis B (AHB) admitted in our hospital between 2003-2005; 12 of them (4.76%) had a co-infection with hepatitis D virus. Most of the patients were young males with an urban origin. The route of transmission was unknown in 8/12 cases. Abdominal pain was more frequent during the onset of the disease than in AHB (p < 0.05). A cholestatic pattern was noted in 9 cases. The frequency of severe/ fulminant cases was greater then in AHB. The HBsAg was absent in 3 patients, and the HBV-DNA was present at low levels in 3/12 patients tested. Two patients had HBsAg present 6 month later.
Vâţa
A
A
Spitalul Clinic de Boli infectioase, Iaşi.
Hurmuzache
M
M
Duca
Elena
E
Scripcariu
Didona
D
Florea
D
D
Petrovici
Cristina
C
Butur
D
D
Luca
V
V
D000293:Adolescent; D000328:Adult; D005260:Female; D006509:Hepatitis B / Q000150:complications* / Q000453:epidemiology / Q000821:virology; D006515:Hepatitis B virus; D003699:Hepatitis D / Q000150:complications* / Q000453:epidemiology / Q000821:virology; D003698:Hepatitis Delta Virus; D006801:Humans; D008297:Male; D015995:Prevalence; D012189:Retrospective Studies; D012383:Romania / Q000453:epidemiology