title: Hypotony and choroidal detachment as a complication of topical combined timolol and dorzolamide.
abstract: OBJECTIVE
  Hypotony with choroidal detachment is a rare complication of glaucoma medication. In this study, we report on a case which supports the hypothesis that has been proposed to explain this phenomenon.
  
  
  METHODS
  This study was designed as an observational case report.
  
  
  METHODS
  A woman with chronic glaucoma underwent trabeculectomy on both eyes. Low intraocular pressure (IOP) developed in 1 eye only, with no visual change for many years. After cataract surgery, the IOP increased, necessitating treatment with topical timolol 0.5% and dorzolamide 2%. She developed monocular hypotony and choroidal detachment 3 months later. This complication occurred in the eye that had previously had a low IOP and resolved completely when topical medication was stopped. The choroidal detachment recurred when rechallenged with the same medication.
  
  
  CONCLUSIONS
  Topical aqueous suppression therapy can result in hypotony and choroidal detachment in an eye in which relatively low IOP has been maintained for many years after glaucoma filtration surgery. The problem resolves on stopping the medication.
authors: Department of Ophthalmology, Oxford Eye Clinic, Oxford, UK.
authors: Tarun
authors: T
authors: Sharma
authors: John F
authors: JF
authors: Salmon
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000009:adverse effects*; D000959:Antihypertensive Agents / Q000627:therapeutic use; D002257:Carbonic Anhydrase Inhibitors / Q000009:adverse effects*; D002387:Cataract Extraction; D015862:Choroid Diseases / Q000139:chemically induced*; D002908:Chronic Disease; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D005260:Female; D005902:Glaucoma, Open-Angle / Q000188:drug therapy; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D000077338:Latanoprost; D008875:Middle Aged; D015814:Ocular Hypotension / Q000139:chemically induced*; D009883:Ophthalmic Solutions / Q000009:adverse effects; D011461:Prostaglandins F, Synthetic / Q000627:therapeutic use; D012008:Recurrence; D013449:Sulfonamides / Q000009:adverse effects*; D013876:Thiophenes / Q000009:adverse effects*; D013999:Timolol / Q000009:adverse effects*; D014130:Trabeculectomy
chemical_list: D000319:Adrenergic beta-Antagonists; D000959:Antihypertensive Agents; D002257:Carbonic Anhydrase Inhibitors; D009883:Ophthalmic Solutions; D011461:Prostaglandins F, Synthetic; D013449:Sulfonamides; D013876:Thiophenes; D000077338:Latanoprost; D013999:Timolol; C062765:dorzolamide