[Pulmonary edema during calcium-channel blockers therapy: role of predisposing or pharmacologic factors?].
Calcium channel blockers of the dihydropyridin's family have been associated with the onset of an acute pulmonary edema when they are used as a treatment of preterm labor. We report here four cases of pulmonary edema in pregnant women treated with nicardipine (Loxen) for preterm labor. The physiopathology of pulmonary edema, the pharmacology of calcium channel blockers of dihydropyridin's family and the detailed analysis of our cases and those of the literature make us discuss of the role of these agents and associated population and risk factors in such complication.
Akerman
G
G
Maternité Port-Royal, hôpital Cochin, 27, rue du Faubourg-Saint-Jacques, 75014 Paris, France.
Mignon
A
A
Tsatsaris
V
V
Jacqmin
S
S
Cabrol
D
D
Goffinet
F
F
D000328:Adult; D002121:Calcium Channel Blockers / Q000009:adverse effects*; D003922:Diabetes Mellitus, Type 1 / Q000150:complications; D004200:Diseases in Twins / Q000150:complications; D005260:Female; D005330:Fetofetal Transfusion / Q000150:complications; D006801:Humans; D009529:Nicardipine / Q000009:adverse effects*; D007752:Obstetric Labor, Premature / Q000188:drug therapy*; D011225:Pre-Eclampsia; D011247:Pregnancy; D011654:Pulmonary Edema / Q000139:chemically induced* / Q000175:diagnosis*; D014427:Twins
D002121:Calcium Channel Blockers; D009529:Nicardipine