title: [TNFalpha and sVCAM plasma levels during standard exercise test are higher in postmenopausal women with hypercholesterolemia].
abstract: OBJECTIVE
  The evaluation of serum ICAM, VCAM, endothelin-1 (Et-1), TNF-alpha and its soluble receptor levels and the secretion of nitric oxide in postmenopausal women with hypercholesterolemia.
  
  
  METHODS
  26 postmenopausal patients who neither received hormonal therapy nor cholesterol lowering treatment. Group A consisted of 16 women with high serum total cholesterol and group B of 10 women with normal cholesterol level.
  
  
  METHODS
  Basic fasting serum FSH, 17beta-estradiol, as well as total cholesterol, HDL-cholesterol, LDL-cholesterol and triglycerides levels were evaluated. Standard exercise test was carried out according to Bruce protocol. Blood samples were taken thrice (prior to, at peak exercise, 15th min of recovery) during the test to evaluate the serum levels of ICAM, VCAM, ET-1, TNF-alpha and its soluble receptors as well as secretion of nitric oxide.
  
  
  RESULTS
  In group A--sVCAM (660.0 +/- 106.4 mg/l versus 518.6 +/- 65.4 mg/l; p < 0.05) and TNF-alpha serum levels (2.2 +/- 1.0 ng/l versus 1.2 +/- 0.4 ng/l; p < 0.05) at peak exercise were higher in group A compared to group B. There was a tendency (p > 0.05) of higher ET-1 plasma levels in group A.
  
  
  CONCLUSIONS
  Serum levels of adhesion molecules and inflammatory mediators were higher during physical exercise in postmenopausal women with atherosclerosis risk factors.
authors: Klinika Endokrynologii Ginekologicznej, Collegium Medicum, Uniwersytetu Jagiellońskiego w Krakowie. momilewi@cyf-kr.edu.pl
authors: Tomasz
authors: T
authors: Milewicz
authors: Renata
authors: R
authors: Rajtar
authors: Danuta
authors: D
authors: Fedak
authors: Władysława
authors: W
authors: Kolasińska-Kloch
authors: Józef
authors: J
authors: Krzysiek
authors: Tomasz
authors: T
authors: Banach
authors: Piotr
authors: P
authors: Thor
mesh_terms: D000704:Analysis of Variance; D016232:Endothelins / Q000097:blood; D005080:Exercise Test; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood*; D008875:Middle Aged; D009569:Nitric Oxide / Q000097:blood; D017698:Postmenopause / Q000097:blood*; D018124:Receptors, Tumor Necrosis Factor / Q000097:blood; D012016:Reference Values; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*; D015854:Up-Regulation; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood*
chemical_list: D016232:Endothelins; D018124:Receptors, Tumor Necrosis Factor; D014409:Tumor Necrosis Factor-alpha; D019010:Vascular Cell Adhesion Molecule-1; D009569:Nitric Oxide