Design and synthesis of 2,3,5-substituted imidazolidin-4-one inhibitors of BACE-1.
Barrow
James C
JC
Department of Medicinal Chemistry, Merck Research Laboratories, P.O Box 4, WP14-1, West Point, PA 19486, USA. james_barrow@merck.com
Rittle
Kenneth E
KE
Ngo
Phung L
PL
Selnick
Harold G
HG
Graham
Samuel L
SL
Pitzenberger
Steven M
SM
McGaughey
Georgia B
GB
Colussi
Dennis
D
Lai
Ming-Tain
MT
Huang
Qian
Q
Tugusheva
Katherine
K
Espeseth
Amy S
AS
Simon
Adam J
AJ
Munshi
Sanjeev K
SK
Vacca
Joseph P
JP
D053829:Amyloid Precursor Protein Secretases / Q000037:antagonists & inhibitors* / Q000737:chemistry; D016282:Aspartic Acid Endopeptidases / Q000037:antagonists & inhibitors* / Q000737:chemistry; D001665:Binding Sites; D018360:Crystallography, X-Ray; D006860:Hydrogen Bonding; D048289:Imidazolidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013058:Mass Spectrometry; D008958:Models, Molecular; D011480:Protease Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
D048289:Imidazolidines; D011480:Protease Inhibitors; D053829:Amyloid Precursor Protein Secretases; D016282:Aspartic Acid Endopeptidases; C509280:BACE1 protein, human