Model systems for activation of nucleic acid encoded prodrugs.
The development of more selective chemotherapeutic agents for benign treatments of malicious diseases is highly desirable. In recent years model systems for the release of small molecule drugs from nucleic acid conjugates by templated chemical or photochemical reactions have been designed. Common for these systems is that the stoichiometric or catalytic drug release is controlled by the highly selective hybridization between complementary strands of nucleic acids. Herein, the concepts of the new field of nucleic acid templated release reactions are outlined.
Jacobsen
Mikkel F
MF
Centre for DNA Nanotechnology, Center for Catalysis and Interdisciplinary Nanoscience Center (iNANO), Department of Chemistry, University of Aarhus, Langelandsgade 140, 8000 Aarhus C, Denmark.
Cló
Emiliano
E
Mokhir
Andriy
A
Gothelf
Kurt V
KV
D002384:Catalysis; D016503:Drug Delivery Systems / Q000379:methods / Q000639:trends; D006801:Humans; D008956:Models, Chemical; D009696:Nucleic Acids / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D010777:Photochemistry / Q000379:methods; D011355:Prodrugs / Q000737:chemistry* / Q000378:metabolism*; D026082:Singlet Oxygen / Q000737:chemistry; D013698:Templates, Genetic
D009696:Nucleic Acids; D011355:Prodrugs; D026082:Singlet Oxygen