Validation of alternative methods of preparing 99mTc-MAG3.
Parameters in the preparation of 99mTc-mertiatide (99mTc-MAG3) were investigated to determine the importance of total activity, activity concentration, boiling time, and delay before boiling for the radiochemical purity (RCP) and stability of the product. Satisfactory RCP results (>90%) were obtained over a range of concentrations including a dilute preparation for paediatric use. RCP was not affected by the time between the addition of pertechnetate and boiling, but low RCP (<60%) resulted when the kit was boiled for less than 10 min.
Seetharaman
Shankar
S
Department of Pharmacy, Guy's and St Thomas' Hospital, Lambeth Palace Road, London SE1 9EH, UK.
Sosabowski
Michael H
MH
Ballinger
James R
JR
D002648:Child; D004355:Drug Stability; D006801:Humans; D007553:Isotope Labeling; D008722:Methods; D010372:Pediatrics; D019275:Radiopharmaceuticals / Q000138:chemical synthesis; D017263:Technetium Tc 99m Mertiatide / Q000138:chemical synthesis*
D019275:Radiopharmaceuticals; D017263:Technetium Tc 99m Mertiatide