title: Nitric oxide affects serum ferritin levels in children with iron deficiency.
abstract: In iron deficiency, serum levels of ferritin decrease. The lack of iron has been thought to be the main factor in this decrease, but another potential factor is nitric oxide, which has been shown to affect ferritin metabolism in vitro. The aim of this study was therefore to evaluate in children with iron deficiency the relation of serum ferritin, nitric oxide degradation products (nitrate and nitrite), and endothelin-1, a protein closely related to nitric oxide function. A total of 80 children were included in the study (39 with iron deficiency, 41 controls). Serum levels of ferritin, nitrate, nitrite, and endothelin-1 were measured in all participants. In children with iron deficiency, nitrate and nitrite levels were significantly higher (p < .009 and .01, respectively). Also, serum ferritin was negatively correlated with serum levels of nitrate and nitrite (p = .034, r = -.254 for nitrate and p = .01, r = -.593 for nitrite). No statistical relationship was found between serum ferritin and endothelin-1.
authors: Faculty of Medicine, Department of Pediatrics, Division of Pediatric Cardiology, Fatih University, Ankara, Turkey.
authors: Ender
authors: E
authors: Odemis
authors: Cemile
authors: C
authors: Koca
authors: Ahmet
authors: A
authors: Karadag
authors: Ferhat
authors: F
authors: Catal
authors: Murat
authors: M
authors: Aydin
authors: Sadi
authors: S
authors: Turkay
authors: Ramazan
authors: R
authors: Yigitoglu
mesh_terms: D000293:Adolescent; D000740:Anemia / Q000209:etiology; D015415:Biomarkers / Q000097:blood; D002648:Child; D002675:Child, Preschool; D019332:Endothelin-1 / Q000097:blood; D005260:Female; D005293:Ferritins / Q000097:blood*; D006801:Humans; D007223:Infant; D007501:Iron / Q000378:metabolism; D000090463:Iron Deficiencies; D008297:Male; D009566:Nitrates / Q000097:blood; D009569:Nitric Oxide / Q000494:pharmacology*; D009573:Nitrites / Q000097:blood
chemical_list: D015415:Biomarkers; D019332:Endothelin-1; D009566:Nitrates; D009573:Nitrites; D009569:Nitric Oxide; D005293:Ferritins; D007501:Iron