title: Genotoxicity screening for N-nitroso compounds. Electrochemical and electrochemiluminescent detection of human enzyme-generated DNA damage from N-nitrosopyrrolidine.
abstract: We report for the first time voltammetric/electrochemiluminescent sensors applied to predict genotoxicity of N-nitroso compounds bioactivated by human cytochrome P450 enzymes.
authors: Department of Chemistry (U-60), 55 N. Eagleville Rd., University of Connecticut, Connecticut, USA.
authors: Sadagopan
authors: S
authors: Krishnan
authors: Eli G
authors: EG
authors: Hvastkovs
authors: Besnik
authors: B
authors: Bajrami
authors: Ingela
authors: I
authors: Jansson
authors: John B
authors: JB
authors: Schenkman
authors: James F
authors: JF
authors: Rusling
mesh_terms: D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D004247:DNA / Q000737:chemistry / Q000378:metabolism*; D004249:DNA Damage / Q000187:drug effects*; D004563:Electrochemistry; D006801:Humans; D008163:Luminescent Measurements; D015394:Molecular Structure; D009242:N-Nitrosopyrrolidine / Q000737:chemistry / Q000378:metabolism* / Q000633:toxicity*
chemical_list: D004247:DNA; D003577:Cytochrome P-450 Enzyme System; D009242:N-Nitrosopyrrolidine