The effect of statins on postprandial lipemia.
Several studies showed that postprandial plasma triglyceride (TG) concentrations are higher in patients with coronary heart disease. TG-rich lipoprotein remnants accumulated in the postprandial state are involved in atherogenesis and in events leading to thrombosis. Lipid lowering drugs, such as 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors (statins) are of significant benefit in the primary and secondary prevention of atherosclerosis. Statins can decrease total cholesterol and low density lipoprotein cholesterol as well as TG concentrations and improve postprandial lipoprotein metabolism. Since abnormal postprandial lipemia is associated with pathological conditions, its treatment is relevant. This review considers the effect of statins on postprandial lipemia.
Kolovou
Genovefa D
GD
Cardiology Department, Onassis Cardiac Surgery Center, Athens, Greece. genovefa@kolovou.com
Anagnostopoulou
Katherine K
KK
Salpea
Klelia D
KD
Daskalopoulou
Stella S
SS
Mikhailidis
Dimitri P
DP
D050197:Atherosclerosis / Q000517:prevention & control; D002784:Cholesterol / Q000097:blood; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D006949:Hyperlipidemias / Q000188:drug therapy*; D019518:Postprandial Period; D016896:Treatment Outcome; D014280:Triglycerides / Q000097:blood
D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D014280:Triglycerides; D002784:Cholesterol