title: Is the follicular lymphoma international prognostic index better than the international prognostic index to identify high-risk follicular lymphoma patients?
abstract: The aims of this study are to validate follicular lymphoma international prognostic index (FLIPI) prognostic score and to compare it with the international prognostic index (IPI) in a cohort of 57 Brazilian patients. According to IPI, 24 patients (42%) were in the low-risk, 28 (49%) in the intermediate-risk, and 4 (7%) in the high-risk group. The distribution according to FLIPI was: 20 (35%) in the low-risk, 8 (14%) in the intermediate-risk, and 29 (51%) in the high-risk group. According to IPI score, median OS was not reached for the low-risk, it was 45 months for the intermediate-risk and 25 months for the high-risk group (p < 0.001). When FLIPI score was applied, median OS was not reached for the low and intermediate-risk, and was 42 months for the high-risk group (p = 0.0064). These findings suggest that: (1) FLIPI score could be validated in a Brazilian population; (2) FLIPI is more accurate than IPI to identify FL patients having worse prognosis (51%); (3) IPI seems to be a better tool for clinical decisions because it selected a smaller high-risk group (7%) having worse prognosis. In our opinion, IPI high-risk patients are the real candidates for more aggressive therapies, avoiding unnecessary over-treatment.
authors: Hematology and Transfusion Service, Sao Paulo, Brazil.
authors: Leina Yukari
authors: LY
authors: Etto
authors: Vanderleia Costa
authors: VC
authors: Silva
authors: Riguel Jun
authors: RJ
authors: Inaoka
authors: Roberta Pasianotto
authors: RP
authors: Costa
authors: Antonio Correa
authors: AC
authors: Alves
authors: Gisele W B
authors: GW
authors: Colleoni
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001938:Brazil / Q000453:epidemiology; D015331:Cohort Studies; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007391:International Cooperation; D008224:Lymphoma, Follicular / Q000175:diagnosis* / Q000453:epidemiology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D033581:Stem Cell Transplantation
chemical_list: D000970:Antineoplastic Agents