title: Steepened aortoseptal angle may be a risk factor for discrete subaortic stenosis in adults.
abstract: Discussion exists whether discrete subaortic stenosis (DSS) is a congenital or acquired cardiac defect. Currently, it is regarded an "acquired" cardiac defect presumably secondary to altered flow patterns due to morphological abnormalities in the left ventricular outflow tract, as have been shown by some studies in the pediatric population. In this report, we demonstrated a steepened aortoseptal angle in adults with DSS without previous cardiac surgery in comparison to controls. Our results strengthen the hypothesis that altered flow patterns due to a steepened aortoseptal angle are a substrate for development of DSS in adults.
authors: Sing-Chien
authors: SC
authors: Yap
authors: Jolien W
authors: JW
authors: Roos-Hesselink
authors: Ad J J C
authors: AJ
authors: Bogers
authors: Folkert J
authors: FJ
authors: Meijboom
mesh_terms: D000328:Adult; D001011:Aorta / Q000002:abnormalities / Q000473:pathology*; D021922:Discrete Subaortic Stenosis / Q000209:etiology / Q000473:pathology*; D005260:Female; D006346:Heart Septum / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors