[Carnosine and diseases of central nervous system].
The naturally-occurring dipeptide carnosine (beta-alanyl-L-histidine) is found exclusively in animal tissues, such as brain and skeletal muscle tissues. Carnosine is a potent hydrophilic antioxidant, antiglycating agent, reactive oxygen species scavenger and pH-buffer. Recent reports suggest that carnosine has potential therapeutic applications in many diseases of central nervous system, such as Alzheimer's disease, Parkinson's disease and cerebral ischemic diseases. To investigate the relationship between carnosine and diseases of central nervous system, and to research and develop carnosine drugs will shed light on a new way for treatment of diseases of central nervous system.
Shen
Yao
Y
Department of Pharmacology, College of Medicine, Zhejiang University, Hangzhou 310058, China.
Hu
Wei-Wei
WW
Chen
Zhong
Z
D000544:Alzheimer Disease / Q000188:drug therapy; D001927:Brain Diseases / Q000188:drug therapy; D002545:Brain Ischemia / Q000188:drug therapy; D002336:Carnosine / Q000627:therapeutic use*; D002493:Central Nervous System Diseases / Q000188:drug therapy*; D006801:Humans; D010300:Parkinson Disease / Q000188:drug therapy
D002336:Carnosine