title: TDP-43 gene analysis in frontotemporal lobar degeneration.
abstract: It has recently been established that the ubiquitinated neuronal inclusions and neurites observed in frontotemporal lobar degeneration (FTLD) contain the TAR DNA-binding protein, TDP-43. It is not uncommon for genetic variation of genes that encode proteins that accumulate in neurodegenerative conditions to increase risk for disease. We therefore examined whether variation of the TDP-43 locus was associated with an increased risk of disease in the Manchester FTLD cohort. We found no evidence of TDP-43 variation increasing risk for FTLD in this cohort. These data suggest that TDP-43 accumulation is a consequence of the disease process underlying FTLD.
authors: Division of Regenerative Medicine, Department of Medicine, University of Manchester, Oxford Road, Manchester M13 9PT, UK.
authors: Sara
authors: S
authors: Rollinson
authors: Julie S
authors: JS
authors: Snowden
authors: David
authors: D
authors: Neary
authors: Karen E
authors: KE
authors: Morrison
authors: David M A
authors: DM
authors: Mann
authors: Stuart M
authors: SM
authors: Pickering-Brown
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D004252:DNA Mutational Analysis / Q000379:methods; D004268:DNA-Binding Proteins / Q000235:genetics*; D003704:Dementia / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D004268:DNA-Binding Proteins