title: Molecular pharmacokinetics of catharanthus (vinca) alkaloids.
abstract: This review focuses on the published data regarding the molecular determinants (enzymes, transporters, orphan nuclear receptors) of Catharanthus (vinca) alkaloids pharmacokinetics in humans. The clinical impact of these determinants (drug disposition, drug-drug interactions) is also discussed.
authors: Pharmacy-Pharmacology, Hôpital Hautepierre, Avenue Molière, 67000 Strasbourg, France.
authors: Dominique
authors: D
authors: Levêque
authors: François
authors: F
authors: Jehl
mesh_terms: D018435:ATP Binding Cassette Transporter, Subfamily B / Q000378:metabolism; D030008:Catharanthus / Q000737:chemistry; D004347:Drug Interactions; D006801:Humans; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism; D014748:Vinca Alkaloids / Q000493:pharmacokinetics*
chemical_list: D018435:ATP Binding Cassette Transporter, Subfamily B; D018160:Receptors, Cytoplasmic and Nuclear; D014748:Vinca Alkaloids