Technetium-99m-labeling and synthesis of thymidine analogs: potential candidates for tumor imaging.
The technetium-99m-labeling and synthesis of a series of thymidine analogs were studied. The target molecules were obtained by using 6-hydrazinopyridine-3-carboxylic acid (HYNIC) as a bifunctional coupling agent and using N-(2-hydroxy-1,1-bis(hydroxymethyl)ethyl)glycine (tricine) and ethylenediamine-N,N'-diacetic acid (EDDA) as coligands. The effects of different spacers between thymidine analog with HYNIC on radiochemical yield were also studied.
Teng
Bao
B
Department of Chemistry, Tsinghua University, Beijing 100084, PR China.
Bai
Yunpeng
Y
Chang
Yu
Y
Chen
Shizhen
S
Li
Zhaolong
Z
D002614:Chelating Agents / Q000737:chemistry; D004492:Edetic Acid / Q000031:analogs & derivatives / Q000737:chemistry; D005998:Glycine / Q000031:analogs & derivatives / Q000737:chemistry; D007553:Isotope Labeling; D008024:Ligands; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008956:Models, Chemical; D009369:Neoplasms / Q000175:diagnosis*; D019275:Radiopharmaceuticals / Q000138:chemical synthesis; D013667:Technetium / Q000737:chemistry*; D013936:Thymidine / Q000031:analogs & derivatives / Q000138:chemical synthesis
D002614:Chelating Agents; D008024:Ligands; D019275:Radiopharmaceuticals; C026058:EDDA; D013667:Technetium; D004492:Edetic Acid; D005998:Glycine; D013936:Thymidine; C100184:tricine