title: SPR imaging-based salivary diagnostics system for the detection of small molecule analytes.
abstract: Saliva is an underused fluid with considerable promise for biomedical testing. Its potential is particularly great for monitoring small-molecule analytes since these are often present in saliva at concentrations that correlate well with their free levels in blood. We describe the development of a prototype diagnostic device for the rapid detection of the antiepileptic drug (AED) phenytoin in saliva. The multicomponent system includes a hand-portable surface plasmon resonance (SPR) imaging instrument and a disposable microfluidic assay card.
authors: Department of Bioengineering, University of Washington, Seattle, WA 98195, USA. efu@u.washington.edu
authors: Elain
authors: E
authors: Fu
authors: Timothy
authors: T
authors: Chinowsky
authors: Kjell
authors: K
authors: Nelson
authors: Kyle
authors: K
authors: Johnston
authors: Thayne
authors: T
authors: Edwards
authors: Kristen
authors: K
authors: Helton
authors: Michael
authors: M
authors: Grow
authors: John W
authors: JW
authors: Miller
authors: Paul
authors: P
authors: Yager
mesh_terms: D015415:Biomarkers / Q000032:analysis / Q000737:chemistry / Q000378:metabolism; D044085:Microfluidics; D012463:Saliva / Q000737:chemistry*; D020349:Surface Plasmon Resonance / Q000295:instrumentation / Q000379:methods
chemical_list: D015415:Biomarkers