title: CINRG pilot trial of oxatomide in steroid-naïve Duchenne muscular dystrophy.
abstract: The authors report a pilot open-label two-center therapeutic trial of oxatomide in 14 steroid-naive DMD boys aged 5-10 years. Comparison of linear evolutions between 3 months medication-free lead-in periods and 6 months treatment periods showed no significant differences in quantitative (QMT) and manual (MMT) measurements of muscle strength and timed functional tests. A modest mitigation of strength deterioration over time cannot be excluded.
authors: University Hospitals KU Leuven, Leuven, Herestraat 49, B-3000 Leuven, Belgium. gunnar.buyse@uz.kuleuven.ac.be
authors: Gunnar M
authors: GM
authors: Buyse
authors: Nathalie
authors: N
authors: Goemans
authors: Erik
authors: E
authors: Henricson
authors: Alejandro
authors: A
authors: Jara
authors: Marleen
authors: M
authors: van den Hauwe
authors: Robert
authors: R
authors: Leshner
authors: Julaine M
authors: JM
authors: Florence
authors: Jill E
authors: JE
authors: Mayhew
authors: Diana M
authors: DM
authors: Escolar
mesh_terms: D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006634:Histamine H1 Antagonists / Q000627:therapeutic use*; D006801:Humans; D016014:Linear Models; D008297:Male; D053580:Muscle Strength / Q000187:drug effects; D020388:Muscular Dystrophy, Duchenne / Q000188:drug therapy*; D010865:Pilot Projects; D010879:Piperazines / Q000627:therapeutic use*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D006634:Histamine H1 Antagonists; D010879:Piperazines; C015408:oxatomide