title: Ultrasonic tissue characterization via 2-D spectrum analysis: theory and in vitro measurements.
abstract: A theoretical model is described for application in ultrasonic tissue characterization using a calibrated 2-D spectrum analysis method. This model relates 2-D spectra computed from ultrasonic backscatter signals to intrinsic physical properties of tissue microstructures, e.g., size, shape, and acoustic impedance. The model is applicable to most clinical diagnostic ultrasound systems. Two experiments employing two types of tissue architectures, spherical and cylindrical scatterers, are conducted using ultrasound with center frequencies of 10 and 40 MHz, respectively. Measurements of a tissue-mimicking phantom with an internal suspension of microscopic glass beads are used to validate the theoretical model. Results from in vitro muscle fibers are presented to further elucidate the utility of 2-D spectrum analysis in ultrasonic tissue characterization.
authors: Department of Radiation Oncology, Columbia University, New York, New York 10032, USA.
authors: Tian
authors: T
authors: Liu
authors: Frederic L
authors: FL
authors: Lizzi
authors: Jeffrey A
authors: JA
authors: Ketterling
authors: Ronald H
authors: RH
authors: Silverman
authors: Gerald J
authors: GJ
authors: Kutcher
mesh_terms: D000465:Algorithms; D000818:Animals; D002417:Cattle; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D015233:Models, Statistical; D008962:Models, Theoretical; D009132:Muscles / Q000473:pathology; D009369:Neoplasms / Q000175:diagnosis* / Q000473:pathology; D016011:Normal Distribution; D010363:Pattern Recognition, Automated; D019047:Phantoms, Imaging; D013057:Spectrum Analysis / Q000295:instrumentation / Q000379:methods*; D014465:Ultrasonics; D014463:Ultrasonography / Q000295:instrumentation* / Q000379:methods*