Chemoselective C(sp3)-H bond activation for the preparation of condensed N-heterocycles.
Condensed N-heterocycles were prepared by using C-H activation reactions catalyzed by Pd(OAc)2 (5 mol %) and (p-tolyl)3P (10 mol %). The key step of these ring closures is chemoselective intramolecular C-H activation of the methyl group at position 2 of the pyrrole ring. Functionalized 9H-pyrrolo[1,2-a]indoles and pyrrolo[1,2-f]phenanthridine derivatives were prepared in good yields. The preparation of some complex N-heterocycles by using successive reactions is also described.
Ren
Hongjun
H
Ludwig-Maximilians-Universität München, Department Chemie und Biochemie, Butenandtstrasse 5-13, Haus F, 81377 München, Germany.
Li
Zhuo
Z
Knochel
Paul
P
D002384:Catalysis; D006571:Heterocyclic Compounds / Q000138:chemical synthesis*; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D010165:Palladium / Q000737:chemistry; D010617:Phenanthridines / Q000138:chemical synthesis* / Q000737:chemistry; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry
D006571:Heterocyclic Compounds; D007211:Indoles; D010617:Phenanthridines; D011758:Pyrroles; D010165:Palladium