title: [The influence of the EGF on proliferative signal transduction in ciliate Tetrahymena pyriformis].
abstract: It has been shown that the transduction of the proliferative signal induced by EGF in ciliata Tetrahymena pyriformis cells is not connected with autophosphorylation of the receptor tyrosine kinases. The results obtained indicate that EGF in ciliata cells initiates the mitogenic pathway including the membrane proteins of the tyrosine kinases-like type (without tyrosine phosphorylation sites), adenylate cyclase, tyrosine- and Ca2+ -dependent ERK-like kinases.
authors: I V
authors: IV
authors: Shemarova
authors: G V
authors: GV
authors: Selivanova
authors: T D
authors: TD
authors: Vlasova
mesh_terms: D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D049109:Cell Proliferation; D004815:Epidermal Growth Factor / Q000502:physiology*; D048049:Extracellular Signal-Regulated MAP Kinases / Q000378:metabolism; D008565:Membrane Proteins / Q000378:metabolism; D008938:Mitosis; D010766:Phosphorylation; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D015398:Signal Transduction; D013769:Tetrahymena pyriformis / Q000254:growth & development*
chemical_list: D008565:Membrane Proteins; D004815:Epidermal Growth Factor; D011505:Protein-Tyrosine Kinases; D048049:Extracellular Signal-Regulated MAP Kinases; D000262:Adenylyl Cyclases