Increased dopamine D2High receptors in knockouts of the dopamine transporter and the vesicular monoamine transporter may contribute to spontaneous hyperactivity and dopamine supersensitivity.
Seeman
Philip
P
Department of Pharmacology, University of Toronto, Toronto, Ontario, Canada. philip.seeman@utoron
Hall
Frank Scott
FS
Uhl
George
G
D000818:Animals; D001667:Binding, Competitive / Q000187:drug effects; D003342:Corpus Striatum / Q000187:drug effects; D004294:Domperidone / Q000493:pharmacokinetics; D004298:Dopamine / Q000494:pharmacology; D018492:Dopamine Antagonists / Q000493:pharmacokinetics; D050483:Dopamine Plasma Membrane Transport Proteins / Q000172:deficiency*; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D017448:Receptors, Dopamine D2 / Q000378:metabolism*; D050493:Vesicular Monoamine Transport Proteins / Q000172:deficiency*
D018492:Dopamine Antagonists; D050483:Dopamine Plasma Membrane Transport Proteins; D017448:Receptors, Dopamine D2; D050493:Vesicular Monoamine Transport Proteins; D004294:Domperidone; D004298:Dopamine