Concomitant presentation of acute myeloid leukemia with T-cell large granular lymphocytic leukemia.
T-cell large granular lymphocyte leukemia (T-LGL) also known as T-cell chronic lymphocytic leukemia is rare and comprises a small minority of all small lymphocytic leukemias. The concomitant presentation of T-LGL with acute myeloid leukemia (AML) has not been previously reported. We present an elderly gentleman with concomitant T-LGL and AML (non-M3) diagnosed by a combination of morphologic evaluation, immunophenotyping by flow cytometry, and T-cell gene rearrangement studies. The patient was managed with combination AML chemotherapy. He remains alive and well seven months after initial diagnosis. A brief review of literature is also presented.
Malani
Ashok Kumar
AK
Department of Hematology and Oncology, Heartland Regional Medical Center, St Joseph, Missouri, USA. drmalani@yahoo.com
Gupta
Chakshu
C
Rangineni
Rajgopal
R
Singh
Jaswinder
J
Ammar
Hussam
H
D000208:Acute Disease; D000369:Aged, 80 and over; D015703:Antigens, CD / Q000032:analysis; D005434:Flow Cytometry; D006801:Humans; D007951:Leukemia, Myeloid / Q000150:complications / Q000175:diagnosis*; D015461:Leukemia, Prolymphocytic, T-Cell / Q000175:diagnosis*; D008297:Male
D015703:Antigens, CD