Late onset nephrogenic diabetes insipidus following cessation of lithium therapy.
Lithium-induced diabetes insipidus occurs in up to one third of patients on long-term therapy. It usually manifests during the treatment course, often with preceding signs or symptoms. We wish to highlight a case in which diabetes insipidus developed many days after cessation of long-term lithium therapy. We seek to explain this delayed onset by a discussion of the molecular and genetic changes underlying the pathogenesis of lithium-induced nephrogenic diabetes insipidus.
Paw
H
H
Intensive Care Department, York Hospital, York, United Kingdom.
Slingo
M E
ME
Tinker
M
M
D017668:Age of Onset; D000368:Aged; D018692:Antimanic Agents / Q000009:adverse effects*; D018500:Diabetes Insipidus, Nephrogenic / Q000139:chemically induced* / Q000175:diagnosis*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016651:Lithium Carbonate / Q000009:adverse effects*
D018692:Antimanic Agents; D016651:Lithium Carbonate