A signal for the caspase-1 inflammasome free of TLR.
Secretion of the proinflammatory cytokine IL-1beta requires caspase-1 and Toll-like receptor (TLR) signaling. However, Kanneganti et al. (2007) find that bacteria can use pore-forming mechanisms to activate caspase-1 for the production of IL-1beta precursor independently of TLRs.
Dinarello
Charles A
CA
Department of Medicine, University of Colorado Health Sciences Center, 4200 East Ninth Avenue B168, Denver, CO 80262, USA. cdinare333@aol.com
D000818:Animals; D020170:Caspase 1 / Q000378:metabolism*; D006801:Humans; D007249:Inflammation / Q000201:enzymology / Q000276:immunology*; D053583:Interleukin-1beta / Q000378:metabolism*; D051193:Toll-Like Receptors / Q000378:metabolism*
D053583:Interleukin-1beta; D051193:Toll-Like Receptors; D020170:Caspase 1