Maternal leptin concentrations are similar in African Americans and Caucasians in normal pregnancy, preeclampsia and small-for-gestational-age infants.
Leptin concentrations were measured in African American women in order to assess leptin's role in the increased frequency and severity of preeclampsia. In addition, leptin concentrations were measured in women who delivered small-for-gestational-age (SGA) infants. A case-control study of African American and Caucasian women with normal pregnancies, preeclampsia, or SGA infants was done. Plasma leptin was quantitated by radio-immunoassay. The previously recognized pattern of increased leptin concentrations in preeclampsia was replicated. Leptin concentrations did not differ by race in any diagnostic category, and concentrations in women with SGA infants were not higher than those in healthy women. Differences in the frequency and severity of preeclampsia in African Americans cannot be explained by higher leptin concentrations.
Jenkins
Laura D
LD
Magee-Womens Research Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA. jenkinsld@upmc.edu
Powers
Robert W
RW
Adotey
Mary
M
Gallaher
Marcia J
MJ
Markovic
Nina
N
Ness
Roberta B
RB
Roberts
James M
JM
D000328:Adult; D001741:Black or African American; D015992:Body Mass Index; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age / Q000097:blood*; D020738:Leptin / Q000097:blood*; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D044465:White People
D020738:Leptin