Immunization with PspA incorporated into a poly(ethylene oxide) matrix elicits protective immunity against Streptococcus pneumoniae.
CBA/N mice were immunized with PspA in a poly(ethylene oxide) matrix to examine its ability to deliver the antigen and modulate the immune response. All mice receiving PspA in the matrix survived a lethal pneumococcal challenge and had serum anti-PspA antibody levels statistically higher than mice receiving PspA alone (P < 0.009).
Moore
Quincy C
QC
Department of Microbiology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA.
Johnson
LaShundra
L
Repka
Michael
M
McDaniel
Larry S
LS
D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics / Q000276:immunology*; D005027:Ethylene Oxide / Q000737:chemistry*; D051379:Mice; D008808:Mice, Inbred CBA; D011008:Pneumococcal Infections / Q000276:immunology / Q000517:prevention & control*; D022242:Pneumococcal Vaccines / Q000276:immunology*; D011108:Polymers / Q000737:chemistry; D011994:Recombinant Proteins / Q000276:immunology; D013296:Streptococcus pneumoniae / Q000276:immunology*; D014611:Vaccination
D001426:Bacterial Proteins; D022242:Pneumococcal Vaccines; D011108:Polymers; D011994:Recombinant Proteins; C051592:pneumococcal surface protein A; D005027:Ethylene Oxide