Comparison of urinary and recombinant human chorionic gonadotropin during ovulation induction in intrauterine insemination cycles: a prospective randomized clinical trial.
OBJECTIVE
To compare the in vivo effectiveness of recombinant (r) hCG with urinary (u) hCG during controlled ovarian hyperstimulation and intrauterine insemination (COH-IUI) cycles.


METHODS
Prospective controlled clinical study.


METHODS
Private IVF center.


METHODS
Two hundred eighty-four subjects undergoing COH-IUI cycles.


METHODS
Women were randomized into receiving r-hCG or u-hCG for final maturation and induction of ovulation.


METHODS
Clinical pregnancy rate and outcome of pregnancy.


RESULTS
Background characteristics were similar in the two groups studied except for a slight difference in the mean duration of infertility (3.0 vs. 2.3). There was no significant difference in the number of follicles > or =16 mm, mean peak E(2), or mean 1-week P levels between the two groups. The clinical pregnancy rate was 27.1% in the recombinant group compared with 28.5% in the urinary group. The outcome of pregnancy was similar in both groups.


CONCLUSIONS
Recombinant hCG was found to be as effective as u-hCG in achieving pregnancy during COH-IUI cycles. This is in agreement with earlier studies on the effectiveness of r-hCG in IVF cycles.
Sakhel
Khaled
K
Synergy Medical Education Alliance, Michigan State University, Saginaw, Michigan, USA.
Khedr
Mohamed
M
Schwark
Sandra
S
Ashraf
Mohammad
M
Fakih
Michael H
MH
Abuzeid
Mostafa
M
D006063:Chorionic Gonadotropin / Q000627:therapeutic use / Q000652:urine*; D005260:Female; D006801:Humans; D007315:Insemination, Artificial / Q000379:methods*; D008297:Male; D010053:Ovary / Q000187:drug effects / Q000502:physiology*; D010062:Ovulation Induction; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000453:epidemiology; D018873:Pregnancy Rate; D011446:Prospective Studies; D011994:Recombinant Proteins / Q000627:therapeutic use
D006063:Chorionic Gonadotropin; D011994:Recombinant Proteins