title: Vogt-Koyanagi-Harada disease presenting as optic neuritis.
abstract: Vogt-Koyanagi-Harada (VKH) disease is a granulomatous multisystem inflammatory disorder that classically affects the uvea, inner ear, meninges, and skin. We report three patients who presented with initial findings suggestive of bilateral optic neuritis requiring CSF analysis and brain images. None of these patients had extraocular changes. Fluorescein angiography of the retina led to the diagnosis of VKH disease in all patients. Vogt-Koyanagi-Harada disease should be included in differential diagnosis of bilateral optic neuritis, even when extraocular manifestations of the disease are absent. In such cases, fluorescein angiography will aid diagnosis.
authors: Doheny Eye Institute and the Department of Ophthalmology, Keck School of Medicine of the University of Southern California, 1450 San Pablo Street, DVRC 211, Los Angeles, CA 90033, USA.
authors: Ranjan
authors: R
authors: Rajendram
authors: Monica
authors: M
authors: Evans
authors: Rahul N
authors: RN
authors: Khurana
authors: Julie H
authors: JH
authors: Tsai
authors: Narsing A
authors: NA
authors: Rao
mesh_terms: D000328:Adult; D001921:Brain / Q000473:pathology; D005260:Female; D005451:Fluorescein Angiography; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009902:Optic Neuritis / Q000175:diagnosis* / Q000188:drug therapy; D011241:Prednisone / Q000627:therapeutic use; D012189:Retrospective Studies; D013129:Spinal Puncture; D014607:Uveomeningoencephalitic Syndrome / Q000175:diagnosis* / Q000188:drug therapy
chemical_list: D005938:Glucocorticoids; D011241:Prednisone