Central atrial natriuretic peptide in dehydration.
To test the effect of dehydration on brain atrial natriuretic peptide (ANP) concentrations in areas important to salt appetite, water balance and cardiovascular regulation, we subjected rats to dehydration and rehydration and measured ANP concentration in 18 brain areas, as well as all relevant peripheral parameters. Water deprivation decreased body weight, blood pressure, urine volume, and plasma ANP, while it increased urine and plasma osmolality, angiotensin II, and vasopressin. ANP greatly increased in 17 and 18 brain areas (all cut cerebral cortex) by 24 h. Rehydration for 12 h corrected all changes evoked by dehydration, including elevated ANP levels in brain. We conclude that chronic dehydration results in increased ANP in brain areas important to salt appetite and water balance. These results support a role for ANP as a neuroregulatory substance that participates in salt and water balance.
Bahner
Udo
U
KfH Nierenzentrum, Hans-Brandmann-Weg 1, D-97080 Würzburg, Germany.
Geiger
Helmut
H
Palkovits
Miklós
M
Lenkei
Zsolt
Z
Luft
Friedrich C
FC
Heidland
August
A
D000804:Angiotensin II / Q000097:blood; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000097:blood / Q000378:metabolism*; D001794:Blood Pressure; D001835:Body Weight; D001921:Brain / Q000378:metabolism; D002540:Cerebral Cortex / Q000378:metabolism*; D003681:Dehydration / Q000378:metabolism*; D008297:Male; D009994:Osmolar Concentration; D051381:Rats; D017208:Rats, Wistar; D013894:Thirst; D013997:Time Factors; D014556:Urine; D014667:Vasopressins / Q000097:blood; D014882:Water-Electrolyte Balance
D014667:Vasopressins; D000804:Angiotensin II; D009320:Atrial Natriuretic Factor