Role of the ABC transporter PRP1 (ABCC7) in pentamidine resistance in Leishmania amastigotes.
Pentamidine is a second-line agent in the treatment of leishmaniasis whose mode of action and resistance mechanism are not well understood. In this work, we show that the intracellular ABC protein PRP1 (pentamidine resistance protein 1) (ABCC7) can confer resistance to pentamidine in Leishmania sp. parasites in the intracellular stage.
Coelho
Adriano C
AC
Instituto de Medicina Tropical, Universidade de São Paulo, Av Dr Enéas de Carvalho Aguiar, 470, 4 andar, São Paulo, Brazil.
Messier
Nadine
N
Ouellette
Marc
M
Cotrim
Paulo C
PC
D018528:ATP-Binding Cassette Transporters / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D000981:Antiprotozoal Agents / Q000494:pharmacology*; D002460:Cell Line; D004351:Drug Resistance / Q000235:genetics; D006801:Humans; D007891:Leishmania / Q000145:classification / Q000187:drug effects* / Q000254:growth & development*; D008264:Macrophages / Q000469:parasitology*; D009000:Monocytes / Q000469:parasitology; D021261:Parasitic Sensitivity Tests; D010419:Pentamidine / Q000494:pharmacology*; D015800:Protozoan Proteins / Q000235:genetics / Q000378:metabolism; D011993:Recombinant Fusion Proteins / Q000235:genetics / Q000378:metabolism
D018528:ATP-Binding Cassette Transporters; D000981:Antiprotozoal Agents; D015800:Protozoan Proteins; D011993:Recombinant Fusion Proteins; C480121:pentamidine resistance protein 1, Leishmania major; D010419:Pentamidine