title: Antielastin autoimmunity in tobacco smoking-induced emphysema.
abstract: Chronic obstructive pulmonary disease and emphysema are common destructive inflammatory diseases that are leading causes of death worldwide. Here we show that emphysema is an autoimmune disease characterized by the presence of antielastin antibody and T-helper type 1 (T(H)1) responses, which correlate with emphysema severity. These findings link emphysema to adaptive immunity against a specific lung antigen and suggest the potential for autoimmune pathology of other elastin-rich tissues such as the arteries and skin of smokers.
authors: Department of Medicine, Section of Pulmonary and Critical Care, Baylor College of Medicine, Houston, Texas 77030, USA.
authors: Seung-Hyo
authors: SH
authors: Lee
authors: Sangeeta
authors: S
authors: Goswami
authors: Ariel
authors: A
authors: Grudo
authors: Li-Zhen
authors: LZ
authors: Song
authors: Venkata
authors: V
authors: Bandi
authors: Sheila
authors: S
authors: Goodnight-White
authors: Linda
authors: L
authors: Green
authors: Joan
authors: J
authors: Hacken-Bitar
authors: Joseph
authors: J
authors: Huh
authors: Faisal
authors: F
authors: Bakaeen
authors: Harvey O
authors: HO
authors: Coxson
authors: Sebastian
authors: S
authors: Cogswell
authors: Claudine
authors: C
authors: Storness-Bliss
authors: David B
authors: DB
authors: Corry
authors: Farrah
authors: F
authors: Kheradmand
mesh_terms: D015551:Autoimmunity; D001402:B-Lymphocytes / Q000276:immunology; D004549:Elastin / Q000276:immunology*; D004646:Emphysema / Q000209:etiology* / Q000276:immunology*; D006801:Humans; D008168:Lung; D029424:Pulmonary Disease, Chronic Obstructive / Q000209:etiology / Q000276:immunology; D012907:Smoking / Q000009:adverse effects* / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
chemical_list: D004549:Elastin