Non-apoptogenic Ca2+-related extrusion of mitochondria in anoxia/reoxygenation stress.
Tumor cells often develop molecular strategies for survival to anoxia/reoxygenation stress as part of tumor progression. Here we describe that the B lymphoma Epstein-Barr-positive cells E2r survive reoxygenation in spite of a very high and long-lasting increase in cytosolic Ca2+ and the loss of about half of their mitochondria due to specific extrusion of the organelles from the cells. The extrusion typically occurs 3 days after reoxygenation, and a regular mitochondrial asset is regained after further 24 h.
Dorio
Annalisa
A
Dipartimento di Biologia, Università di Roma Tor Vergata, via Ricerca Scientifica 1, 00133 Roma, Italy.
Cerella
Claudia
C
De Nicola
Milena
M
D'Alessio
Maria
M
Gualandi
Giampiero
G
Ghibelli
Lina
L
D017209:Apoptosis; D002118:Calcium / Q000378:metabolism*; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D006801:Humans; D008928:Mitochondria / Q000378:metabolism*; D010100:Oxygen / Q000378:metabolism*
D010100:Oxygen; D002118:Calcium