title: Health-related quality of life in secondary progressive multiple sclerosis.
abstract: Common disability scales in multiple sclerosis (MS) are often weighted towards physical disability. Non-motor symptoms such as depression, fatigue and pain substantially influence wellbeing in MS. Health-related quality of life (HRQoL) measures the broader impact of MS and might indicate less obvious disease burdens. We analysed HRQoL, using the Nottingham Health Profile Part I (NHP-I), among 345 secondary progressive MS (SPMS) patients participating in a randomized trial of interferon-beta1a (IFN-beta1a), 22 mug subcutaneously weekly, or matching placebo. The results did not reveal any beneficial effect of IFN-beta1a in any outcome measure. NHP-I sub- and sum scores were compared for 217 population controls and correlated with demographic and clinical disease variables. SPMS patients had lower NHP-I sum and all subscores than the controls. Patients experiencing disease progression reported worse NHP-I sum scores. Increased fatigue, Expanded Disability Status Scale (EDSS) and Arm Index scores were independently associated with reduction in several NHP-I subscores. SPMS patients had significantly lower HRQoL than controls and physical disability (EDSS and Arm Index), disease progression and fatigue strongly influenced this. MS.
authors: Department of Neurology, University Hospital of Akershus, Lørenskog, Norway. antonie.beiske@ahus.no
authors: A G
authors: AG
authors: Beiske
authors: H
authors: H
authors: Naess
authors: J H
authors: JH
authors: Aarseth
authors: O
authors: O
authors: Andersen
authors: I
authors: I
authors: Elovaara
authors: M
authors: M
authors: Farkkila
authors: H J
authors: HJ
authors: Hansen
authors: S I
authors: SI
authors: Mellgren
authors: M
authors: M
authors: Sandberg-Wollheim
authors: P S
authors: PS
authors: Sorensen
authors: K M
authors: KM
authors: Myhr
mesh_terms: D018450:Disease Progression; D004644:Emotions; D005221:Fatigue; D005260:Female; D006304:Health Status; D006801:Humans; D008297:Male; D051346:Mobility Limitation; D020528:Multiple Sclerosis, Chronic Progressive / Q000503:physiopathology* / Q000523:psychology; D010146:Pain; D011788:Quality of Life; D012890:Sleep; D012934:Social Isolation