title: A multicenter randomized, controlled study comparing laparoscopic versus minilaparotomic myomectomy: reproductive outcomes.
abstract: OBJECTIVE
  To assess the reproductive outcomes after minilaparotomic and laparoscopic myomectomy in patients wishing to conceive.
  
  
  METHODS
  Randomized controlled trial.
  
  
  METHODS
  Departments of obstetrics and gynecology of the universities of Catanzaro, Rome, and Florence, Italy.
  
  
  METHODS
  One hundred thirty-six women with symptomatic uterine leiomyomas or unexplained infertility.
  
  
  METHODS
  Laparoscopic and minilaparotomic myomectomy.
  
  
  METHODS
  Pregnancy, abortion, and live-birth rates.
  
  
  RESULTS
  Between the laparoscopic and minilaparotomic groups no difference was observed in cumulative pregnancy, live-birth, and abortion rates, whereas pregnancy and live-birth rates per cycle, and time to first pregnancy and live-birth were significantly higher in the laparoscopic than in the minilaparotomic group. Categorizing the patients according to surgical indication for myomectomy, cumulative pregnancy rate, pregnancy, and live-birth rates per cycle, and time to first pregnancy and live-birth were significantly better after laparoscopic myomectomy in symptomatic patients, whereas all reproductive outcomes were similar between the two groups in patients with unexplained infertility.
  
  
  CONCLUSIONS
  Minilaparotomic and laparoscopic myomectomy improves in a similar manner the reproductive outcomes in patients with unexplained infertility, whereas the laparoscopic approach provides the best benefits in fertile patients with symptomatic leiomyomas.
authors: Department of Obstetrics & Gynecology, University Magna Graecia of Catanzaro, Catanzaro, Italy. stefanopalomba@tin.it
authors: Stefano
authors: S
authors: Palomba
authors: Errico
authors: E
authors: Zupi
authors: Angela
authors: A
authors: Falbo
authors: Tiziana
authors: T
authors: Russo
authors: Daniela
authors: D
authors: Marconi
authors: Achille
authors: A
authors: Tolino
authors: Francesco
authors: F
authors: Manguso
authors: Alberto
authors: A
authors: Mattei
authors: Fulvio
authors: F
authors: Zullo
mesh_terms: D000328:Adult; D005260:Female; D013509:Gynecologic Surgical Procedures / Q000379:methods*; D006801:Humans; D007247:Infertility, Female / Q000601:surgery*; D010535:Laparoscopy / Q000379:methods*; D007813:Laparotomy / Q000379:methods; D007889:Leiomyoma / Q000601:surgery*; D009215:Myometrium / Q000601:surgery*; D011247:Pregnancy; D011256:Pregnancy Outcome; D018873:Pregnancy Rate; D014594:Uterine Neoplasms / Q000601:surgery*