Behavioural measures in frontotemporal lobar dementia and other dementias: the utility of the frontal behavioural inventory and the neuropsychiatric inventory in a national cohort study.
BACKGROUND
Distinguishing between patients with frontotemporal lobar dementia (FTLD) and other dementing illnesses remains a difficult task for many clinicians. In this study, we aimed to provide further evidence for the construct validity of the frontal behavioural inventory (FBI) and assess its utility in differentiating FTLD patients from other groups using data from the Canadian Collaborative Cohort of Related Dementias (ACCORD) study.


METHODS
Baseline scores on the FBI and neuropsychiatric inventory (NPI) were compared among several clinical groups (n = 177).


RESULTS
The FBI discriminated a higher percentage of FTLD patients (>75% correct classification) from Alzheimer's disease and other groups compared to the NPI (54.2%).


CONCLUSIONS
This study provides good evidence for convergent validity between the FBI and NPI (r = 0.72), indicating that both measures capture similar psychopathology in this nationwide cohort.
Blair
M
M
Department of Cognitive Neurology and Alzheimer's Research Centre, St. Joseph's Health Care, University of Western Ontario, London, Canada. Mervin.Blair@sjhc.london.on.ca
Kertesz
A
A
Davis-Faroque
N
N
Hsiung
G-Y R
GY
Black
S E
SE
Bouchard
R W
RW
Gauthier
S
S
Guzman
D A
DA
Hogan
D B
DB
Rockwood
K
K
Feldman
H
H
D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D001526:Behavioral Symptoms / Q000175:diagnosis* / Q000209:etiology; D015331:Cohort Studies; D003704:Dementia / Q000145:classification / Q000150:complications / Q000175:diagnosis*; D003937:Diagnosis, Differential; D005260:Female; D005625:Frontal Lobe / Q000503:physiopathology*; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D010552:Personality Assessment; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity