Effects of octenidine HCl on liver tissue: could it be an alternative scolicidal for Hidatid disease?
Octenidine HCl is new topical antiseptic solution for wounds and abdominal washing that has been found to be highly effective for inactivating scolices in an in vitro study. However, the effects of octenidine HCl on the liver are not yet known. The aim of this study was to determine if there are any histopathologic changes after injecting octenidine HCl into the liver. A group of 50 male Sprague-Dawley rats were included in the study and randomly divided into five groups of 10 rats each, as follows: sham group; 0.09% NaCl group; 20% NaCl group; undiluted octenidine HCl group; 1% octenidine HCl group. The scolicidal agents (0.3 ml) were directly injected into the left lobe of the liver (except in the sham group). At 3 and 7 days after the injection, the rats were sacrificed, and the left lobe of the liver was harvested. Liver tissue was scored for degree of necrosis and the diameter of the necrosis examined under light microscopy. The highest scores were found in the undiluted octenidine HCl group, although a similar effect was observed in the 20% NaCl group. There was no necrosis in the sham group, the 0.09% NaCl group, or the 1% octenidine HCl group. All of the injury was coagulation-type necrosis. No mortality was observed throughout the study. The 1% octenidine HCl solution could thus be used as a scolicidal agent in liver tissue, whereas the undiluted form of octenidine and 20% NaCl solutions were shown to cause necrosis when directly injected into liver tissue in our animal model.
Arikan
Yüksel
Y
Department of General Surgery, Afyonkarahisar Kocatepe University, School of Medicine, Tip Fakültesi, Genel Cerrahi AD, Ali Cetinkaya Kampüsü, 03200, Afyon Karahisar, Turkey.
Akbulut
Gökhan
G
Sahin
Dursun Ali
DA
Dilek
Fatma Hüsniye
FH
Saykol
Volkan
V
Dilek
Osman Nuri
ON
D000818:Animals; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage / Q000633:toxicity*; D000923:Anticestodal Agents / Q000008:administration & dosage / Q000633:toxicity*; D056486:Chemical and Drug Induced Liver Injury / Q000473:pathology*; D004305:Dose-Response Relationship, Drug; D007097:Imines; D007267:Injections; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008297:Male; D011725:Pyridines / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats; D017207:Rats, Sprague-Dawley
D000891:Anti-Infective Agents, Local; D000923:Anticestodal Agents; D007097:Imines; D011725:Pyridines; C034213:octenidine