title: Antioxidant enzymes and diabetic retinopathy.
abstract: The aim of this study was to discuss the serum copper (Cu), zinc (Zn), nitric oxide (NO), glutathione (GSH), advanced oxidation protein products (AOPP) levels, and superoxide dismutase (SOD) activities with diabetic retinopathy severity. Twenty-five patients with proliferative diabetic retinopathy (PDR group 1), 25 patients with nonproliferative diabetic retinopathy (NPDR group 2), and 25 nondiabetic controls (control group) were included in the study. Patients who had macrovascular complications of diabetes (coronary arterial disease, periferic vascular disease) were excluded. The major finding of our study was that we did not observe any differences between group 1 and 2, which we aimed to discuss the severity of diabetic retinopathy. As the levels of SOD and Zn were not different between the groups, statistically significant differences were observed for GSH, NO, and Cu levels when compared to control group. AOPP levels were statistically increased in group 1 compared to control group. It can be suggested that hyperglycemia in DM is associated with accelerated nonenzymatic glycation and oxidative stress.
authors: Department of Medical Biochemistry, Faculty of Medicine, Gazi University, 06510 Beşevler, Ankara, Turkey. asepici@yahoo.com
authors: Zuhal
authors: Z
authors: Yildirim
authors: N Irem
authors: NI
authors: Uçgun
authors: Nedret
authors: N
authors: Kiliç
authors: E
authors: E
authors: Gürsel
authors: Aylin
authors: A
authors: Sepici-Dinçel
mesh_terms: D000368:Aged; D000975:Antioxidants / Q000378:metabolism*; D003300:Copper / Q000097:blood; D048909:Diabetes Complications / Q000097:blood / Q000235:genetics; D003930:Diabetic Retinopathy / Q000201:enzymology* / Q000235:genetics*; D005260:Female; D005978:Glutathione / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000097:blood; D018384:Oxidative Stress; D010100:Oxygen / Q000378:metabolism; D013482:Superoxide Dismutase / Q000097:blood / Q000378:metabolism; D015032:Zinc / Q000097:blood
chemical_list: D000975:Antioxidants; D009569:Nitric Oxide; D003300:Copper; D013482:Superoxide Dismutase; D005978:Glutathione; D015032:Zinc; D010100:Oxygen