title: Synthesis and cytotoxic activity of trisubstituted-1,3,5-triazines.
abstract: 1,3,5-Triazine derivatives were screened for phototoxicity as well as the cytotoxic activities against leukemia and adenocarcinoma derived cell lines in comparison to the normal human keratinocytes. A simple and environmentally friendly procedure has been developed for the synthesis of 1,3,5-triazine derivatives under microwave irradiation in the presence of a HY zeolite. The catalyst can be recovered and reused. Thus, the procedure provides a simple and green synthetic methodology under environmentally friendly conditions. Structure-activity relationships between the chemical structures and antimycobacterial and photosynthesis-inhibiting activity of the evaluated compounds are also discussed.
authors: Indian Oil Corporation Limited, R&D Center, Faridabad, Haryana 121007, India. aryakapil2001@yahoo.com
authors: Kapil
authors: K
authors: Arya
authors: Anshu
authors: A
authors: Dandia
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000473:pathology; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D045744:Cell Line, Tumor / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D015603:Keratinocytes / Q000166:cytology / Q000187:drug effects* / Q000473:pathology; D007938:Leukemia / Q000188:drug therapy* / Q000473:pathology; D008826:Microbial Sensitivity Tests; D008956:Models, Chemical; D010788:Photosynthesis / Q000187:drug effects*; D013329:Structure-Activity Relationship; D014227:Triazines / Q000138:chemical synthesis / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D014227:Triazines