Oral ulcers produced by mycophenolate mofetil in two liver transplant patients.
Oral ulcers are a frequent problem in transplant medicine. It is important to consider infectious etiologies, exacerbated by the immunosuppressive treatment, but other etiologies are also possible, like adverse drug reactions. Mycophenolate mofetil (MMF) is an immunosuppressive medication that has been used in combination with calcineurin inhibitors and steroids. Reports of renal transplant patients with oral ulcers related to MMF have appeared lately and herein we have described 2 cases in liver transplant patients. Their oral ulcers resolved quickly after suspension of the medication. Our 2 cases in liver transplant patients represented a unique setting for this type of complication.
Naranjo
J
J
Gastroenterology Department, Medicine Service, Clinical Hospital of the University of Chile, Independencia, Santiago, Chile. jotaene67@yahoo.com
Poniachik
J
J
Cisco
D
D
Contreras
J
J
Oksenberg
D
D
Valera
J M
JM
Díaz
J C
JC
Rojas
J
J
Cardemil
G
G
Mena
S
S
Castillo
J
J
Rencoret
G
G
Godoy
J
J
Escobar
J
J
Rodríguez
J
J
Leyton
P
P
Fica
A
A
Toledo
C
C
D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D016572:Cyclosporine / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D016031:Liver Transplantation / Q000276:immunology*; D016106:Methicillin Resistance; D008875:Middle Aged; D009173:Mycophenolic Acid / Q000009:adverse effects / Q000031:analogs & derivatives*; D019226:Oral Ulcer / Q000139:chemically induced*; D013203:Staphylococcal Infections / Q000175:diagnosis / Q000188:drug therapy; D013211:Staphylococcus aureus; D016896:Treatment Outcome
D000900:Anti-Bacterial Agents; D007166:Immunosuppressive Agents; D016572:Cyclosporine; D009173:Mycophenolic Acid