title: Genetic and antigenic analysis of invasive serogroup Y Neisseria meningitidis isolates collected from 1999 to 2003 in Canada.
abstract: One hundred forty serogroup Y Neisseria meningitidis isolates recovered from patients with invasive meningococcal disease (IMD) in Canada from 1999 to 2003 were analyzed by genetic and serological methods. Seventy-four isolates (52.9%) belonged to serotype 2c, and most have serosubtype antigen P1.5,2 (37 isolates, 26%) or P1.5 (31 isolates, 22%). Forty-eight isolates (34.3%) belonged to serotype 14 and have serosubtype antigen P1.5,2 (13 isolates, 9%) or P1.5 (7 isolates, 5%) or were nonserosubtypeable (27 isolates, 19%). Thirteen isolates (9.3%) were nonserotypeable. Multilocus sequence typing identified two unrelated clonal populations of serogroup Y meningococci causing invasive disease in Canada: ST-23 and ST-167 clonal complexes. Almost all ST-167-related isolates were typed as 2c:P1.5, while strains of the ST-23 clonal complex were either serotype 14 or 2c but with the serosubtype antigen P1.5,2. In contrast to previous reports that patients with serogroup Y disease are usually older, 26% of the Canadian serogroup Y cases were found in the 10-to-19-year-old age group and another 11% were in the 20-to-39-year-old age group.
authors: Laboratory for Vaccine Preventable Bacterial Diseases, National Microbiology Laboratory, public Health Agency of Canada, Winnipeg, Manitoba, Canada R3E 3R2. Raymond_Tsang@phac-aspc.gc.ca
authors: Raymond S W
authors: RS
authors: Tsang
authors: Averil M
authors: AM
authors: Henderson
authors: Marissa L
authors: ML
authors: Cameron
authors: Shaun D
authors: SD
authors: Tyler
authors: Shari
authors: S
authors: Tyson
authors: Dennis K S
authors: DK
authors: Law
authors: Jan
authors: J
authors: Stoltz
authors: Wendell D
authors: WD
authors: Zollinger
mesh_terms: D000293:Adolescent; D000328:Adult; D000940:Antigenic Variation; D015373:Bacterial Typing Techniques; D002170:Canada / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008589:Meningococcal Infections / Q000453:epidemiology / Q000382:microbiology*; D008875:Middle Aged; D038581:Neisseria meningitidis, Serogroup Y / Q000145:classification* / Q000235:genetics* / Q000276:immunology / Q000302:isolation & purification; D012703:Serotyping