Analysis of HIV-1 CRF07_BC gag p6 sequences indicating novel deletions in the central region of p6.
We amplified gag sequences from 66 individuals infected with HIV-1 CRF07_BC during 2003-2005 in the Xinjiang region of China. A novel deletion of 7aa (including a KELY motif) in the central region of the CRF07_BC gag p6 domain was detected, which has not been reported in other HIV-1 subtypes. Further deletions of up to 13aa (including KQE and KELY motifs) was also found in this domain, representing the biggest natural deletion up to now. Moreover, the CD4+ count and viral load level indicated that 1-13aa deletions in CRF07_BC gag p6 do not have a significant effect on viral replication and fitness.
Song
Y H
YH
State Key Laboratory for Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, P.R. China.
Meng
Z F
ZF
Xing
H
H
Ruan
Y H
YH
Li
X P
XP
Xin
R L
RL
Ma
P F
PF
Peng
H
H
Shao
Y
Y
D000595:Amino Acid Sequence; D015683:Gene Products, gag / Q000737:chemistry / Q000235:genetics*; D015750:Genes, gag; D015658:HIV Infections / Q000821:virology; D015497:HIV-1 / Q000145:classification* / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D010802:Phylogeny; D016133:Polymerase Chain Reaction; D011995:Recombination, Genetic; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA; D017384:Sequence Deletion; D015819:Substance Abuse, Intravenous / Q000150:complications; D054301:gag Gene Products, Human Immunodeficiency Virus
D015683:Gene Products, gag; D054301:gag Gene Products, Human Immunodeficiency Virus; C083002:p6 gag protein, Human immunodeficiency virus 1