Infective endocarditis due to community-associated methicillin-resistant Staphylococcus aureus in injection drug users may be associated with Panton-Valentine leukocidin-negative strains.
Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) isolates that cause infective endocarditis in injection drug users (IDUs) are distinct from CA-MRSA strains that cause endocardial infection as a complication of skin and soft tissue infections. We present a case of CA-MRSA infective endocarditis, review pertinent cases previously published, and describe the molecular characteristics of strains from IDUs and patients with skin and soft tissue infections.
Tsigrelis
Constantine
C
Department of Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA. tsigrelis.constantine@mayo.edu
Armstrong
Matthew D
MD
Vlahakis
Nicholas E
NE
Batsis
John A
JA
Baddour
Larry M
LM
D000328:Adult; D017714:Community-Acquired Infections / Q000382:microbiology; D004697:Endocarditis, Bacterial / Q000188:drug therapy / Q000382:microbiology* / Q000601:surgery; D006801:Humans; D008297:Male; D016106:Methicillin Resistance; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000382:microbiology* / Q000601:surgery; D013211:Staphylococcus aureus / Q000145:classification / Q000187:drug effects* / Q000472:pathogenicity*; D015819:Substance Abuse, Intravenous / Q000382:microbiology*; D014261:Tricuspid Valve / Q000382:microbiology