title: Design and synthesis of 2,3,5-substituted imidazolidin-4-one inhibitors of BACE-1.
authors: Department of Medicinal Chemistry, Merck Research Laboratories, P.O Box 4, WP14-1, West Point, PA 19486, USA. james_barrow@merck.com
authors: James C
authors: JC
authors: Barrow
authors: Kenneth E
authors: KE
authors: Rittle
authors: Phung L
authors: PL
authors: Ngo
authors: Harold G
authors: HG
authors: Selnick
authors: Samuel L
authors: SL
authors: Graham
authors: Steven M
authors: SM
authors: Pitzenberger
authors: Georgia B
authors: GB
authors: McGaughey
authors: Dennis
authors: D
authors: Colussi
authors: Ming-Tain
authors: MT
authors: Lai
authors: Qian
authors: Q
authors: Huang
authors: Katherine
authors: K
authors: Tugusheva
authors: Amy S
authors: AS
authors: Espeseth
authors: Adam J
authors: AJ
authors: Simon
authors: Sanjeev K
authors: SK
authors: Munshi
authors: Joseph P
authors: JP
authors: Vacca
mesh_terms: D053829:Amyloid Precursor Protein Secretases / Q000037:antagonists & inhibitors* / Q000737:chemistry; D016282:Aspartic Acid Endopeptidases / Q000037:antagonists & inhibitors* / Q000737:chemistry; D001665:Binding Sites; D018360:Crystallography, X-Ray; D006860:Hydrogen Bonding; D048289:Imidazolidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013058:Mass Spectrometry; D008958:Models, Molecular; D011480:Protease Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D048289:Imidazolidines; D011480:Protease Inhibitors; D053829:Amyloid Precursor Protein Secretases; D016282:Aspartic Acid Endopeptidases; C509280:BACE1 protein, human