title: Brain activation during working memory after traumatic brain injury in children.
abstract: Eight children with moderate to severe traumatic brain injury (TBI) and eight matched, uninjured control children underwent fMRI during an N-back task to test effects of TBI on working memory performance and brain activation. Two patterns in the TBI group were observed. Patients whose criterion performance was reached at lower memory loads than control children demonstrated less extensive frontal and extrafrontal brain activation than controls. Patients who performed the same, highest (3-back) memory load as controls demonstrated more frontal and extrafrontal activation than controls. Our findings of performance and brain activation changes in children after TBI await longitudinal investigation.
authors: Cognitive Neuroscience Laboratory, Baylor College of Medicine, Houston, TX 77030, USA. mnewsome@bcm.tmc.edu
authors: Mary R
authors: MR
authors: Newsome
authors: Randall S
authors: RS
authors: Scheibel
authors: Jill V
authors: JV
authors: Hunter
authors: Zhiyue J
authors: ZJ
authors: Wang
authors: Zili
authors: Z
authors: Chu
authors: Xiaoqi
authors: X
authors: Li
authors: Harvey S
authors: HS
authors: Levin
mesh_terms: D000293:Adolescent; D001143:Arousal / Q000502:physiology*; D001930:Brain Injuries / Q000503:physiopathology*; D001931:Brain Mapping; D016022:Case-Control Studies; D002648:Child; D005260:Female; D005625:Frontal Lobe / Q000293:injuries / Q000502:physiology* / Q000503:physiopathology; D015600:Glasgow Coma Scale; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D016555:Matched-Pair Analysis; D008570:Memory, Short-Term / Q000502:physiology*; D012016:Reference Values