Age has no effect on de novo constitutional t(11;22) translocation frequency in sperm.
We analyzed de novo constitutional t(11;22) translocation frequency in sperm derived from normal healthy males as a function of the age of the sperm donors (from 25 to 51). Translocation-specific polymerase chain reaction demonstrated no age-dependent increment in the frequency of the rearrangements.
Kato
Takema
T
Division of Molecular Genetics, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Japan.
Yamada
Kouji
K
Inagaki
Hidehito
H
Kogo
Hiroshi
H
Ohye
Tamae
T
Emanuel
Beverly S
BS
Kurahashi
Hiroki
H
D000328:Adult; D000375:Aging / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013094:Spermatozoa / Q000502:physiology*; D014178:Translocation, Genetic / Q000235:genetics*