[Endothelial injury markers as a possible criterion for the efficiency of treatment for arterial hypertension].
Endothelial injury markers, including endothelial microparticles (CD31+ particles, 1.5-4.0 microm in diameter), von Willebrand factor, endothelin-big 1-38, and plasma concentrations of thiobarbituric acid reactive substances in patients with essential hypertension (EH), were evaluated. The endothelial injury markers and the concentrations of thiobarbituric acid reactive substances were significantly elevated in patients with EH, as compared to healthy subjects and decreased, so was blood pressure in response to antihypertensive pharmacotherapy. However, the patients and the healthy subjects had differences in these parameters. It is suggested that all the studied parameters of endothelial injury are suitable for laboratory monitoring of treatment in patients with EH in different periods of the disease, including a stable blood pressure period.
El'chaninova
S A
SA
Koreniak
N A
NA
Driagina
I V
IV
Makarenko
V V
VV
Smirnova
O I
OI
D000328:Adult; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D015415:Biomarkers / Q000097:blood*; D001795:Blood Pressure Determination; D019332:Endothelin-1 / Q000097:blood; D004730:Endothelium, Vascular / Q000473:pathology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis; D016896:Treatment Outcome; D014841:von Willebrand Factor / Q000032:analysis
D000959:Antihypertensive Agents; D015415:Biomarkers; D019332:Endothelin-1; D017392:Thiobarbituric Acid Reactive Substances; D014841:von Willebrand Factor