title: Hormone replacement therapy, mammography screening and changing age-specific incidence rates of breast cancer: an ecological study comparing two European populations.
abstract: BACKGROUND
  In 2003, for the first time, US breast cancer incidence rates have fallen. Experts argue whether this is due to the reduced uptake of screening mammography or to lower use of Hormone Replacement Therapy (HRT). This study aims to disentangle the respective impact of screening and HRT on age-incidence rates and histology of breast cancer, by comparing two populations with comparably high levels of screening mammography, but with different prevalence of HRT.
  
  
  METHODS
  We included all invasive breast cancers recorded at the Geneva cancer registry (n = 4,909) and the Netherlands Cancer Registry (n = 152,428) between 1989-2003. We compared age-specific incidence rates and trends in histological subtyping between the two populations.
  
  
  RESULTS
  Between 1989-1991, incidence rates increased with age in both populations. In 2001-2003, women aged 60-64 years showed highest incidence rates in Geneva, while in the Netherlands incidence rates continued to increase with age. The annual increase in ductal cancer incidence was similar in the Netherlands (2.3%) and Geneva (2.5%), but the annual increase in lobular cancer was sharper in Geneva (10%) than in the Netherlands (5%).
  
  
  CONCLUSIONS
  The sharp differences in age distribution and histological subtyping of breast cancer between two European populations are not attributable to screening, since both populations have a high uptake of mammography screening. Since the prevalence of HRT use is very high in Geneva and rather low in the Netherlands, HRT may explain these discrepancies. However, other etiological factors and differences in histological assessment may also have played a role.
authors: Geneva Cancer Registry, Institute for Social and Preventive Medicine, Geneva University, 55 Boulevard de la Cluse, Geneva 1205, Switzerland. cofhmv@nus.edu.sg
authors: H M
authors: HM
authors: Verkooijen
authors: V C M
authors: VC
authors: Koot
authors: G
authors: G
authors: Fioretta
authors: M
authors: M
authors: van der Heiden
authors: M E I
authors: ME
authors: Schipper
authors: E
authors: E
authors: Rapiti
authors: P H M
authors: PH
authors: Peeters
authors: J L
authors: JL
authors: Peterse
authors: C
authors: C
authors: Bouchardy
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000453:epidemiology*; D015914:Estrogen Replacement Therapy; D005260:Female; D006801:Humans; D015994:Incidence; D008327:Mammography; D008875:Middle Aged; D009426:Netherlands / Q000453:epidemiology; D013557:Switzerland / Q000453:epidemiology; D013997:Time Factors