title: Robust intravascular optical coherence elastography by line correlations.
abstract: We present a new method for intravascular optical coherence elastography, which is robust against motion artefacts. It employs the correlation between adjacent lines, instead of subsequent frames. Pressure to deform the tissue is applied synchronously with the line scan rate of the optical coherence tomography (OCT) instrument. The viability of the method is demonstrated with a simulation study. We find that the root mean square (rms) error of the displacement estimate is 0.55 microm, and the rms error of the strain is 0.6%. It is shown that high-strain spots in the vessel wall, such as observed at the sites of vulnerable atherosclerotic lesions, can be detected with the technique.
authors: Department of Biomedical Engineering, Thorax Center, Erasmus MC, PO Box 2040, NL-3000 CA Rotterdam, The Netherlands. g.vansoest@erasmusmc.nl
authors: Gijs
authors: G
authors: van Soest
authors: Frits
authors: F
authors: Mastik
authors: Nico
authors: N
authors: de Jong
authors: Anton F W
authors: AF
authors: van der Steen
mesh_terms: D001808:Blood Vessels / Q000473:pathology*; D003198:Computer Simulation; D003324:Coronary Artery Disease / Q000175:diagnosis / Q000473:pathology; D004548:Elasticity; D008962:Models, Theoretical; D019047:Phantoms, Imaging; D041623:Tomography, Optical Coherence / Q000379:methods*