title: Full-thickness macular hole in a patient with diabetic cystoid macular oedema treated by intravitreal triamcinolone injections.
abstract: OBJECTIVE
  Full-thickness macular hole associated with diabetic macular oedema is a rare feature and its pathogenesis remains incompletely elucidated. We report the occurrence of a full-thickness macular hole, documented with optical coherence tomography (OCT), in a patient with diabetic cystoid macular oedema treated by intravitreal triamcinolone injections.
  
  
  METHODS
  A 48-year-old woman with refractory diabetic cystoid macular oedema underwent successive intravitreal triamcinolone injections, which were followed by a progressive thinning of the neurosensory retina at the fovea, and then by a full-thickness macular hole, associated with a perifoveal posterior hyaloid detachment, visible on OCT. During pars plana vitrectomy, a thin epiretinal macular membrane was diagnosed and removed.
  
  
  CONCLUSIONS
  Pathogenesis of the present full-thickness macular hole associated with diabetic macular oedema is different from that of idiopathic macular holes because anteroposterior vitreous tractions were not involved in its formation. Recurrent intravitreal triamcinolone injections may have had an indirect role in the development of the macular hole, by favouring the rupture of distended Muller cells and intraretinal pseudocysts.
authors: Department of Ophthalmology, Lariboisière Hospital, University of Paris, Paris, France. colletamelie@hotmail.com
authors: Amélie
authors: A
authors: Lecleire-Collet
authors: Olivier
authors: O
authors: Offret
authors: David
authors: D
authors: Gaucher
authors: François
authors: F
authors: Audren
authors: Belkacem
authors: B
authors: Haouchine
authors: Pascale
authors: P
authors: Massin
mesh_terms: D003930:Diabetic Retinopathy / Q000188:drug therapy*; D019773:Epiretinal Membrane / Q000175:diagnosis / Q000209:etiology / Q000601:surgery; D005260:Female; D005938:Glucocorticoids / Q000009:adverse effects*; D006801:Humans; D007267:Injections; D008269:Macular Edema / Q000188:drug therapy*; D008875:Middle Aged; D012160:Retina / Q000187:drug effects / Q000473:pathology; D012167:Retinal Perforations / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D019233:Retreatment; D041623:Tomography, Optical Coherence; D014222:Triamcinolone Acetonide / Q000009:adverse effects*; D014821:Vitrectomy; D014822:Vitreous Body
chemical_list: D005938:Glucocorticoids; D014222:Triamcinolone Acetonide