In vivo study of the anti-inflammatory effect of Rhus toxicodendron.
BACKGROUND
Homeopathic Rhus toxicodendron (Rhus tox) is used in various inflammatory conditions. We screened its effect compared to succussed ethanol controls and appropriate active controls.


METHODS
We initially experimented with Rhus tox 6, 12, 30 and 200 cH, using carrageenan-induced paw oedema in rats. The 6 cH dilution appeared most effective and was used in subsequent assays. We used pre-treatment and single treatment regimes in Wistar rats, and mice.


RESULTS
We found significant reductions compared to control in carrageenan-induced paw oedema, vascular permeability, writhing induced by intraperitoneal acetic acid and stress induced gastric lesions.


CONCLUSIONS
Rhus tox in homeopathic dilution appears to interfere with inflammatory processes involving histamine, prostaglandins and other inflammatory mediators.
dos Santos
A L
AL
Faculdade de Ciências da Saúde de São Paulo, R. Bartolomeu de Gusmão, São Paulo, São Paulo, Brazil.
Perazzo
F F
FF
Cardoso
L G V
LG
Carvalho
J C T
JC
D000284:Administration, Oral; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D002199:Capillary Permeability / Q000187:drug effects; D002351:Carrageenan; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy*; D005534:Foot Diseases / Q000139:chemically induced / Q000188:drug therapy*; D006705:Homeopathy / Q000379:methods*; D008297:Male; D051379:Mice; D010146:Pain / Q000517:prevention & control; D010147:Pain Measurement; D008517:Phytotherapy; D051381:Rats; D017208:Rats, Wistar; D029045:Rhus; D013276:Stomach Ulcer / Q000517:prevention & control; D012251:Toxicodendron
D000894:Anti-Inflammatory Agents, Non-Steroidal; D002351:Carrageenan