title: Theoretical comparison of aberration-correcting customized and aspheric intraocular lenses.
abstract: OBJECTIVE
  To assess the performance and optical limitations of standard, aspheric, and wavefront-customized intraocular lenses (IOLs) using clinically verified pseudophakic eye models.
  
  
  METHODS
  White light pseudophakic eye models were constructed from physical measurements performed on 46 individual cataract patients and subsequently verified using the clinically measured contrast sensitivity function (CSF) and wavefront aberration of pseudophakic patients implanted with two different types of IOLs. These models are then used to design IOLs that correct the astigmatism and higher order aberrations of each individual eye model's cornea and to investigate how this correction would affect visual benefit, subjective tolerance to lens misalignment (tilt, decentration, and rotation), and depth of field.
  
  
  RESULTS
  Physiological eye models and clinical outcomes show similar levels of higher order aberration and contrast improvement. Customized correction of ocular wavefront aberrations with an IOL results in contrast improvements on the order of 200% over the control and the Tecnis IOLs. The customized lenses can be, on average, decentered by as much as 0.8 mm, tilted > 10 degrees , and rotated as much as 15 degrees before their polychromatic modulation transfer function at 8 cycles/degree is less than that of the Tecnis or spherical control lens. Correction of wavefront aberration results in a narrower through focus curve but better out of focus performance for +/- 0.50 diopters.
  
  
  CONCLUSIONS
  The use of realistic eye models that include higher order aberrations and chromatic aberrations are important when determining the impact of new IOL designs. Customized IOLs show the potential to improve visual performance.
authors: AMO Groningen, The Netherlands. Patricia.Piers@amo-inc.com
authors: Patricia A
authors: PA
authors: Piers
authors: Henk A
authors: HA
authors: Weeber
authors: Pablo
authors: P
authors: Artal
authors: Sverker
authors: S
authors: Norrby
mesh_terms: D015350:Contrast Sensitivity; D019781:Corneal Topography; D004867:Equipment Design; D006801:Humans; D007910:Lenses, Intraocular; D008954:Models, Biological; D019591:Pseudophakia / Q000473:pathology* / Q000503:physiopathology*