ATP-induced relaxation of porcine retinal arterioles depends on the perivascular retinal tissue and acts via an adenosine receptor.
OBJECTIVE
Purinergic compounds and cyclooxygenase inhibitors are involved in the tone regulation of isolated retinal arterioles in vitro, but it is unknown whether the perivascular retinal tissue influences these effects.


METHODS
Adenosine-and ATP-induced vasodilation of porcine retinal arterioles was studied in a wire myograph before and after removal of the perivascular tissue.


RESULTS
Both adenosine and ATP caused relaxation of the studied arterioles. This effect depended on the perivascular tissue and could be blocked by antagonists but was unaffected by ibuprofen.


CONCLUSIONS
The relaxation of porcine retinal arterioles induced by purinergic compounds is modulated by the perivascular retinal tissue.
Holmgaard
Kim
K
Department of Ophthalmology, Arhus University Hospital, Arhus, Denmark. khj@akhphd.au.dk
Aalkjaer
Christian
C
Lambert
John D C
JD
Bek
Toke
T
D000241:Adenosine / Q000494:pharmacology*; D000255:Adenosine Triphosphate / Q000494:pharmacology*; D000818:Animals; D001160:Arterioles / Q000187:drug effects; D066298:In Vitro Techniques; D009213:Myography; D018047:Receptors, Purinergic P1 / Q000502:physiology*; D012160:Retina / Q000502:physiology*; D012171:Retinal Vessels / Q000187:drug effects*; D013552:Swine; D014664:Vasodilation; D014665:Vasodilator Agents / Q000494:pharmacology*
D018047:Receptors, Purinergic P1; D014665:Vasodilator Agents; D000255:Adenosine Triphosphate; D000241:Adenosine