Resveratrol inhibition of Propionibacterium acnes.
OBJECTIVE
To evaluate the effects of the anti-inflammatory hydroxystilbene, resveratrol, on Propionibacterium acnes growth.


METHODS
Three different strains of P. acnes were tested against resveratrol at concentrations between 0 and 200 mg/L. Piceatannol was included as a second hydroxystilbene to compare with resveratrol, and erythromycin and benzoyl peroxide were used as positive controls.


RESULTS
After 24 h of treatment with resveratrol, the average 50% inhibitory concentration (IC(50)) was 73 mg/L and the average 100% inhibitory concentration (IC(100)) was 187 mg/L for the three strains of P. acnes tested. The IC(50) and IC(100) of piceatannol were 123 and 234 mg/L, respectively. The highest concentration of resveratrol tested (200 mg/L) was bactericidal, whereas lower concentrations were bacteriostatic.


CONCLUSIONS
Resveratrol, an anti-inflammatory hydroxystilbene, is capable of inhibiting P. acnes growth.
Docherty
John J
JJ
Department of Microbiology, Immunology and Biochemistry, Northeastern Ohio Universities College of Medicine, Rootstown, OH 44272, USA. jjd@neoucom.edu
McEwen
Heather A
HA
Sweet
Thomas J
TJ
Bailey
Erin
E
Booth
Tristan D
TD
D000900:Anti-Bacterial Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001585:Benzoyl Peroxide / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004917:Erythromycin / Q000494:pharmacology; D007641:Keratolytic Agents / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D011425:Propionibacterium acnes / Q000187:drug effects* / Q000254:growth & development; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D007641:Keratolytic Agents; D013267:Stilbenes; D004917:Erythromycin; C041525:3,3',4,5'-tetrahydroxystilbene; D000077185:Resveratrol; D001585:Benzoyl Peroxide