Structures of pahayokolides A and B, cyclic peptides from a Lyngbya sp.
The isolation and structure elucidation of two cyclic peptides, pahayokolides A (1) and B (2), is described. Structural features determined for these compounds include a pendent N-acetyl-N-methyl leucine, both E- and Z-dehydrobutyrines, a homophenylalanine, and an unusual polyhydroxy amino acid that is most likely of mixed polyketide synthase/nonribosomal peptide synthase origin. These peptides were purified from a new species of cyanobacteria of the genus Lyngbya, which was isolated from a periphyton mat from the Florida Everglades.
An
Tianying
T
Department of Chemistry and Biochemistry, Florida International University, Miami, Florida 33199, USA.
Kumar
Thallapuranam Krishnaswamy Suresh
TK
Wang
Minglei
M
Liu
Li
L
Lay
Jackson O
JO
Liyanage
Rohana
R
Berry
John
J
Gantar
Miroslav
M
Marks
Vered
V
Gawley
Robert E
RE
Rein
Kathleen S
KS
D000458:Cyanobacteria / Q000737:chemistry*; D005431:Florida; D005618:Fresh Water; D008235:Lyngbya Toxins / Q000737:chemistry*; D015394:Molecular Structure; D010456:Peptides, Cyclic / Q000737:chemistry*
D008235:Lyngbya Toxins; D010456:Peptides, Cyclic; C509972:pahayokolide A; C520504:pahayokolide B