title: Newer cardiac troponin I assays have similar performance to troponin T in patients with end-stage renal disease.
abstract: BACKGROUND
  Troponin T is present in the blood of a majority of patients with endstage renal disease (ESRD) undergoing regular dialysis and presence of troponin T is a predictor of adverse outcome in these patients. With several new formulations of troponin I assays available, this study was performed to see whether these newer assays were able to detect troponin I in these patients more effectively than the older assays.
  
  
  METHODS
  One hundred and forty-three patients undergoing regular haemodialysis or peritoneal dialysis had plasma collected and troponin T and troponin I measured by a variety of assays.
  
  
  RESULTS
  The newer troponin I assays (Abbott Architect, Bayer Centaur and Beckman Accu-TnI) were able to detect troponin I (>75% of samples) as effectively as the Roche assay was able to detect troponin T, while other troponin I assays had a much lower rate of detection of troponin - DPC Immulite 2000 16% and Abbott AxSYM 35%. However, the troponin T assay had more samples detected at concentrations corresponding to an assay CV of 10% (59% of samples) than did the newer troponin I assays (highest on the Bayer Centaur at 37%).
  
  
  CONCLUSIONS
  Newer assays demonstrate that troponin I is present in a similar number of samples as is troponin T, in the blood of patients with dialysis-dependent renal failure, and these newer troponin I assays identify patients at risk of experiencing a cardiac event.
authors: ANU Medical School, Canberra, Australia. peter.hickman@act.gov.au
authors: Peter E
authors: PE
authors: Hickman
authors: Gus
authors: G
authors: Koerbin
authors: Emma
authors: E
authors: Southcott
authors: Jill
authors: J
authors: Tate
authors: Goce
authors: G
authors: Dimeski
authors: Andrew
authors: A
authors: Carter
authors: Darryl
authors: D
authors: McGill
authors: Girish
authors: G
authors: Talaulikar
authors: Julia M
authors: JM
authors: Potter
mesh_terms: D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000628:therapy; D006435:Renal Dialysis; D012680:Sensitivity and Specificity; D019210:Troponin I / Q000097:blood*; D020107:Troponin T / Q000097:blood*
chemical_list: D019210:Troponin I; D020107:Troponin T