Novel amphiphilic ternary polysaccharide derivates chitosan-g-PCL-b-MPEG: synthesis, characterization, and aggregation in aqueous solution.
Chitosan-g-PCL-b-MPEG copolymers of various compositions were successful synthesized via a protection-graft-deprotection procedure, by the esterification of phthaloyl-protected chitosan (PHCS) with MPEG-b-PCL-COOH, which was synthesized from MPEG and epsilon-caprolactone and carboxylated by maleic anhydride. The chemical structure of the chitosan-g-PCL-b-MPEG was characterized by Fourier transform infrared and NMR spectroscopy. The chitosan-g-PCL-b-MPEG was obtained as amphoteric hybrid with amino polysaccharide backbone and amphiphilic MPEG-b-PCL side chain. Their crystallinity and aggregation behavior in aqueous solution were also investigated.
Lu
Yiye
Y
School of Pharmacy, Shanghai Jiaotong University, Shanghai, PR China.
Liu
Li
L
Guo
Shengrong
S
D048271:Chitosan / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D016503:Drug Delivery Systems; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011091:Polyesters / Q000138:chemical synthesis* / Q000737:chemistry; D011092:Polyethylene Glycols / Q000138:chemical synthesis* / Q000737:chemistry; D033362:Powder Diffraction; D012996:Solutions; D017550:Spectroscopy, Fourier Transform Infrared; D013501:Surface-Active Agents; D014867:Water
D011091:Polyesters; D012996:Solutions; D013501:Surface-Active Agents; D014867:Water; C016240:polycaprolactone; D011092:Polyethylene Glycols; C028210:monomethoxypolyethylene glycol; D048271:Chitosan