Surfactant effect on persistence of oxadiazolyl 3(2H)-pyridazinones against Pseudaletia separata walker.
The photodynamic decomposition of two new insect-growth inhibitors (IGRs), 2-tert-butyl-5-[5'-aryl-2'-(1',3',4'-oxadiazolyl)methoxy]-3(2H)-pyridazinones (OPB) and its 4-chloro substituted derivative (OPC), and effect of surfactants on persistence of their bioactivity were taken into investigation. Both chemicals were significantly induced to photolysis by ultraviolet light at 365 nm wavelength and their inhibitory activities against Pseudaletia separata larvae decreased with the increasing irradiation time. However, irradiation at 254 nm wavelength didn't cause their photodegradation. Triton X-100 and Succinic-sulfonie acidic sodium but not Tween 60 possessed strong capability to slow down the decomposition and obviously prolonged the half life of OPC in laboratory and field whilst effects of the three surfactants almost did not preserve the inhibitory activity of OPB. Data suggested that electron-withdrawing halogen (-Cl) on the pi electron system in planar benzene-oxadialyl structures might reduce the efficiency of OPC on ultraviolet (UV) photoabsorption, and its hydrophobic interaction with the surfactants might be beneficial for forming stable micellar solubilization, thus sustaining the chemical's bioactivity.
Huang
Qingchun
Q
Shanghai Key Lab of Chemical Biology, East China University of Science and Technology, Shanghai. China. qchuang@ecust.edu.cn
Wu
Jihua
J
Kong
Yuping
Y
Liu
Manhui
M
Cao
Song
S
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005247:Feeding Behavior / Q000187:drug effects*; D006207:Half-Life; D007306:Insecticides / Q000737:chemistry* / Q000494:pharmacology / Q000528:radiation effects; D007605:Juvenile Hormones / Q000737:chemistry; D007700:Kinetics; D007814:Larva; D009036:Moths / Q000187:drug effects* / Q000254:growth & development; D010069:Oxadiazoles / Q000737:chemistry* / Q000494:pharmacology / Q000528:radiation effects; D010782:Photolysis; D011724:Pyridazines / Q000737:chemistry* / Q000494:pharmacology / Q000528:radiation effects; D013501:Surface-Active Agents / Q000032:analysis / Q000737:chemistry*; D014466:Ultraviolet Rays
D007306:Insecticides; D007605:Juvenile Hormones; D010069:Oxadiazoles; D011724:Pyridazines; D013501:Surface-Active Agents