Oral and maxillofacial manifestations of Gardner's syndrome associated with growth hormone deficiency: case report and literature review.
Gardner's syndrome (GS) is a hereditary disorder inherited as autosomal dominant with complete penetrance and variable expression. GS is a variant of familial adenomatous polyposis characterized by extracolonic manifestations including osteomas, dental anomalies, and epidermoid cysts. The association between GS and endocrine abnormalities has been well documented but a direct pituitary involvement has never been reported. We present a case of oral and maxillofacial manifestations in an adult patient affected by GS associated with growth hormone deficiency, a hitherto unreported association. The possible pathogenic mechanisms are discussed.
Ramaglia
Luca
L
Dipartimento di Scienze Odontostomatologiche e Maxillo-Facciali, University of Naples Federico II, Naples, Italy. luca.ramaglia@unina.it
Morgese
Fabio
F
Filippella
Mariagiovanna
M
Colao
Annamaria
A
D000328:Adult; D005096:Exostoses / Q000209:etiology / Q000601:surgery; D005624:Frontal Bone / Q000473:pathology / Q000601:surgery; D005736:Gardner Syndrome / Q000150:complications*; D019382:Human Growth Hormone / Q000172:deficiency*; D006801:Humans; D007018:Hypopituitarism / Q000150:complications*; D008297:Male; D014095:Tooth, Impacted / Q000209:etiology* / Q000601:surgery; D014096:Tooth, Supernumerary / Q000209:etiology / Q000601:surgery
D019382:Human Growth Hormone