A novel study investigating the therapeutic outcome of patients with lytic, mixed and sclerotic bone metastases treated with combined radiotherapy and ibandronate.
OBJECTIVE
To investigate the therapeutic response of patients with different types of bone metastases treated with combined radiotherapy and bisphosphonates.


METHODS
By using computed tomography 52 patients were grouped into groups of lytic, mixed and sclerotic bone lesions. All patients were treated with concomitant radiotherapy and ibandronate (10 monthly cycles) and underwent clinical and radiological evaluations prior to therapy and at 3, 6 and 10 months of follow up.


RESULTS
At baseline there were statistically significant differences between the three groups for all the evaluated parameters. From 3 months onwards differences were leveled out. Statistically significant improvements were noted at all time points of evaluation for all groups in parameters such as pain (0-10), quality of life (QOL-physical functioning, 0-100) and Karnofsky performance status (KPS). The average pain score for the lytic group was reduced from 8.1 to 1.5 points at 3 months. The corresponding reductions for the mixed and sclerotic groups were from 6.2 to 0.5 and from 4.4 to 0.3 points respectively. Complete pain responses were >76.4% at all time points for all groups. Opioid consumption was also markedly reduced. Overall, the highest clinical response was noted for the lytic group, even though the mean values of pain, QOL and KPS were worse than those of the two other groups at all time points (apart from pain score at 10 months). The percentage of patients of the lytic group experiencing a complete pain response was the least of the three groups during follow up. At 10 months bone density was almost tripled for the lytic and almost doubled for the mixed group.


CONCLUSIONS
Even though the therapeutic outcome for the three groups was similar, the degree of clinical response and reossification differed.
Vassiliou
Vassilios
V
Department of Radiation Oncology, University of Patras Medical School, Athinon 81, 264 41, Patras, Greece.
Kalogeropoulou
Christine
C
Giannopoulou
Efstathia
E
Leotsinidis
Michael
M
Tsota
Irine
I
Kardamakis
Dimitrios
D
D000328:Adult; D000368:Aged; D000701:Analgesics, Opioid / Q000627:therapeutic use; D015519:Bone Density; D001859:Bone Neoplasms / Q000503:physiopathology / Q000523:psychology / Q000556:secondary* / Q000628:therapy*; D003131:Combined Modality Therapy; D004164:Diphosphonates / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D000077557:Ibandronic Acid; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000188:drug therapy; D011788:Quality of Life
D000701:Analgesics, Opioid; D004164:Diphosphonates; D000077557:Ibandronic Acid