Tuning the release rate of acidic degradation products through macromolecular design of caprolactone-based copolymers.
Macromolecular engineering is presented as a tool to control the degradation rate and release rate of acidic degradation products from biomedical polyester ethers. Three different caprolactone/1,5-dioxepan-2-one (CL/DXO) copolymers were synthesized: DXO/CL/DXO triblock, CL/DXO multiblock, and random cross-linked CL/DXO copolymer. The relation of CL and DXO units in all three copolymers was 60/40 mol %. The polymer discs were immersed in phosphate buffer solution at pH 7.4 and 37 degrees C for up to 364 days. After different time periods degradation products were extracted from the buffer solution and analyzed. In addition mass loss, water absorption, molecular weight changes, and changes in thermal properties were determined. The results show that the release rate of acidic degradation products, a possible cause of acidic microclimates and inflammatory responses, is controllable through macromolecular design, i.e., different distribution of the weak linkages in the copolymers.
Hakkarainen
Minna
M
Department of Fibre and Polymer Technology, School of Chemical Science and Engineering, Royal Institute of Technology, S-100 44 Stockholm, Sweden.
Höglund
Anders
A
Odelius
Karin
K
Albertsson
Ann-Christine
AC
D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry; D002021:Buffers; D002208:Caproates / Q000138:chemical synthesis / Q000737:chemistry; D004355:Drug Stability; D006868:Hydrolysis; D006880:Hydroxy Acids / Q000032:analysis*; D007783:Lactones / Q000138:chemical synthesis / Q000737:chemistry; D008422:Materials Testing; D008970:Molecular Weight; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry; D012995:Solubility; D013997:Time Factors
D001672:Biocompatible Materials; D002021:Buffers; D002208:Caproates; D006880:Hydroxy Acids; D007783:Lactones; D011108:Polymers; C121056:caprolactone