[Effect of clearing heat and removing dampness method on formation of pigment gallstones in rabbits].
OBJECTIVE
To observe dynamically the effect of drugs for clearing heat and removing dampness (CHRD) on biliary components in rabbits with pigment gallstones (PGS).


METHODS
Forty rabbits were established into PGS model and randomly divided into 3 groups, the bacterial infection group, the CHRD low-dose group and the CHRD high-dose group. Besides, a normal group was set up with healthy rabbits for control. Changes of total bilirubin (TB), unconjugated bilirubin (UCB), total bile acid (TBA), Ca2+, bacterial and endogenous beta-glucuronidase (beta-Gase) in bile were observed.


RESULTS
CHRD drugs significantly decreased the contents of UCB, Ca2+, bacterial and endogenous beta-Gase (P < 0.05), and increased TBA in bile (P < 0.05).


CONCLUSIONS
CHRD drugs have good effect in reducing the lithogenesis of the pigment gallstones.
Zhang
Xi-bo
XB
Tianjin Medical University.
Cui
Nai-qiang
NQ
Li
Dong-hua
DH
D000818:Animals; D001646:Bile / Q000187:drug effects / Q000378:metabolism; D001654:Bile Pigments / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D042882:Gallstones / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D005966:Glucuronidase / Q000378:metabolism; D008297:Male; D008517:Phytotherapy; D011817:Rabbits; D011897:Random Allocation; D016896:Treatment Outcome
D001654:Bile Pigments; D004365:Drugs, Chinese Herbal; D005966:Glucuronidase; D002118:Calcium