Review. Pro- and anti-angiogenesis effects of resveratrol.
Resveratrol, a natural polyphenol, has a variety of effects including protection against ischemia-reperfusion injury, and antitumor and chemopreventive action against malignant tumors. In recent years, resveratrol has been found to exert pro-and anti-angiogenic effects, depending on the situation. For example, pro-angiogenic effects are noted in the peri-infarct myocardium, whereas resveratrol inhibits angiogenesis in tumors. In this article, a review of the literature concerning both pro-angiogenic and anti-angiogenic effects of resveratrol and the underlying mechanisms of its effects on angiogenesis is presented.
Chen
Yun
Y
Department of Surgery, Far Eastern Memorial Hospital, 21, Sec. 2, Nan-Ya South Road, Banciao, Taipei 220, Taiwan.
Tseng
Sheng-Hong
SH
D043925:Angiogenesis Inducing Agents / Q000494:pharmacology*; D020533:Angiogenesis Inhibitors / Q000494:pharmacology*; D000818:Animals; D006801:Humans; D023421:Models, Animal; D031625:Morus; D010936:Plant Extracts / Q000737:chemistry; D015427:Reperfusion Injury / Q000517:prevention & control*; D000077185:Resveratrol; D013267:Stilbenes / Q000302:isolation & purification / Q000494:pharmacology*; D027843:Vitis
D043925:Angiogenesis Inducing Agents; D020533:Angiogenesis Inhibitors; D010936:Plant Extracts; D013267:Stilbenes; D000077185:Resveratrol