[Investigation on dissolution of cinnabar in vitro].
OBJECTIVE
To study effects of different chemical factors in gastrointestinal tract, i.e. pH, protein, amino acid, ionic strength, Na2S, on the dissolution of cinnabar.


METHODS
The content of total mercury in various dissolution of cinnabar were analyzed by UV/VIS Spectrophotometer. The particle distributions in dissolution of cinnabar were measured by Laser Particle Size Analyzer. The constituents of dissoluble substance of cinnabar in presence of Na2S were determined using ESI-MS.


RESULTS
The solubility of cinnabar could be increased significantly in the presence of Na2S/So, and strong acidic pH, respectively. While the influence of thiol amino acid on promoting dissolution remains relatively low. Cinnabar didnt dissolve mainly in the form of nanoparticle.


CONCLUSIONS
We postulated that cinnabar could be dissolved in various forms of mercury complexes containing sulphur.
Zeng
Ke-wu
KW
Department of Chemical Biology, Peking University School of Pharmaceutical Sciences, Beijing 100083, China.
Wang
Qi
Q
Yang
Xiao-da
XD
Wang
Kui
K
D003545:Cysteine / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D017669:Mercury Compounds / Q000032:analysis / Q000737:chemistry*; D010316:Particle Size; D012995:Solubility; D021241:Spectrometry, Mass, Electrospray Ionization; D013056:Spectrophotometry, Ultraviolet; D013447:Sulfites / Q000737:chemistry*
D017669:Mercury Compounds; D013447:Sulfites; D003545:Cysteine; C025026:sodium sulfite; C034211:cinnabar