[Effects of brain stem and spinal cord by isoflurane inhibiting nociceptive reflex].
OBJECTIVE
To explore the effect positions of the volatile anesthetic inhibiting the nociceptive reflex in the central nervous system.


METHODS
Thirty adult SD rats were randomly and equally divided into two groups that the lip and hind paw of rats were held by clamp. The minimum alveolar concentration (MAC) was determined by clamping two places: one was to clamp the hind paw of rats, of which the nervous reflex is controlled via the spinal cord; the another group was to clamp the lip of rats, of which the nervous reflex is controlled through the brain stem.


RESULTS
The isoflurane MAC was 1.44% +/- 0.09% in clamping the hind paw group, while 1.29% +/- 0.11% for clamping the lip group (P < 0.05).


CONCLUSIONS
Both brain stem and spinal cord are the effect positions of volatile anesthetics (especially isoflurane).
Yang
Jing
J
Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu 610041, China.
Wang
Xiao-Wei
XW
Zhang
Zi-Yun
ZY
Huang
Qing-Qing
QQ
Liu
Tong
T
Hu
Tong-Zeng
TZ
D000777:Anesthetics / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D000818:Animals; D001933:Brain Stem / Q000166:cytology / Q000187:drug effects* / Q000502:physiology*; D005260:Female; D007530:Isoflurane / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D008297:Male; D009619:Nociceptors / Q000166:cytology / Q000187:drug effects*; D011650:Pulmonary Alveoli / Q000378:metabolism; D051381:Rats; D012018:Reflex / Q000187:drug effects*; D013116:Spinal Cord / Q000166:cytology / Q000187:drug effects* / Q000502:physiology*; D014835:Volatilization
D000777:Anesthetics; D007530:Isoflurane