title: Effects of hydrated forms of C60 fullerene on amyloid 1-peptide fibrillization in vitro and performance of the cognitive task.
abstract: It has been shown for the first time by transmission electron microscopy that the hydrated fullerene C60 inhibited the fibrillization of amyloid-beta25-35 peptide. The fullerene affected the amyloid-beta25-35 assembly, manifesting its anti-amyloidogenic capacity. Our in vivo investigations demonstrated also that a single intracerebroventricular injection of the C60 hydrated fullerene at a dose of 7.2 nmol/ventricle significantly improved the performance of the cognitive task in control rats. The intracerebroventricular injection of the C60 hydrated fullerene (3.6 nmol/ventricle) prevented the impairment of performance of the cognitive task induced by amyloid-beta25-35 (22.5 nmol/ventricle). The results obtained may be useful in the development of therapy of Alzheimer's disease.
authors: Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Russia.
authors: I Ya
authors: IY
authors: Podolski
authors: Z A
authors: ZA
authors: Podlubnaya
authors: E A
authors: EA
authors: Kosenko
authors: E A
authors: EA
authors: Mugantseva
authors: E G
authors: EG
authors: Makarova
authors: L G
authors: LG
authors: Marsagishvili
authors: M D
authors: MD
authors: Shpagina
authors: Yu G
authors: YG
authors: Kaminsky
authors: G V
authors: GV
authors: Andrievsky
authors: V K
authors: VK
authors: Klochkov
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy; D000595:Amino Acid Sequence; D000682:Amyloid / Q000737:chemistry*; D016229:Amyloid beta-Peptides / Q000737:chemistry; D000818:Animals; D001522:Behavior, Animal; D001921:Brain / Q000473:pathology; D004195:Disease Models, Animal; D037741:Fullerenes / Q000737:chemistry* / Q000494:pharmacology*; D006624:Hippocampus / Q000187:drug effects*; D007858:Learning; D008297:Male; D046529:Microscopy, Electron, Transmission; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000737:chemistry; D010455:Peptides / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000682:Amyloid; D016229:Amyloid beta-Peptides; D037741:Fullerenes; D010446:Peptide Fragments; D010455:Peptides; C074636:amyloid beta-protein (25-35); C069837:fullerene C60