Risk assessment in haematopoietic stem cell transplantation: pre-transplant patient and donor factors: non-HLA genetics.
Non-HLA genetics involving the study of single-nucleotide polymorphisms (SNPs) and microsatellites of cytokine and cytokine receptor genes, and as well as genes associated with response to infection and therapeutic drugs, are currently being studied for associations with diseases, including autoimmune disease, cancer and solid-organ transplant rejection. This chapter will summarize the potential role of non-HLA genetics in predicting outcome of haematopoietic stem-cell transplantation (HSCT) and how genotyping for non-HLA genes may give insight into the immunobiology of HSCT complications, including GvHD and infectious episodes. Future directions - including the role of pharmacogenomics, use of the research results for individualized medicine, and interpretation of data - will also be discussed.
Dickinson
Anne M
AM
School of Clinical and Laboratory Sciences, Haematological Sciences, Newcastle University, The Medical School, Newcastle upon Tyne NE2 4HH, UK. a.m.dickinson@ncl.ac.uk
D016207:Cytokines / Q000235:genetics; D006085:Graft Survival / Q000276:immunology; D006086:Graft vs Host Disease / Q000276:immunology / Q000517:prevention & control; D018380:Hematopoietic Stem Cell Transplantation; D006648:Histocompatibility / Q000276:immunology; D006650:Histocompatibility Testing; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology; D007125:Immunogenetics; D007371:Interferon-gamma / Q000235:genetics; D007375:Interleukin-1 / Q000235:genetics; D016753:Interleukin-10 / Q000235:genetics; D015850:Interleukin-6 / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D018570:Risk Assessment; D014019:Tissue Donors; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics
D016207:Cytokines; D007375:Interleukin-1; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; D007371:Interferon-gamma