title: The use of unsymmetrical indirect covariance NMR methods to obtain the equivalent of HSQC-NOESY data.
abstract: We have recently demonstrated that unsymmetrical indirect covariance NMR methods can be used to mathematically calculate the equivalent of low sensitivity, hyphenated NMR experiments by combining data from a pair of higher sensitivity experiments. The present report demonstrates the application of this method to the combination of HSQC and NOESY spectra to provide results comparable to HSQC-NOESY data, albeit with greater sensitivity and with considerably less spectrometer time.
authors: Advanced Chemistry Development, Moscow Department, 6 Akademik Bakulev Street, Moscow 117513, Russian Federation, Russia.
authors: Kirill A
authors: KA
authors: Blinov
authors: Antony J
authors: AJ
authors: Williams
authors: Bruce D
authors: BD
authors: Hilton
authors: Patrick A
authors: PA
authors: Irish
authors: Gary E
authors: GE
authors: Martin
mesh_terms: D007052:Ibuprofen / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy / Q000379:methods* / Q000592:standards*; D012680:Sensitivity and Specificity; D013995:Time
chemical_list: D007052:Ibuprofen