title: Interface interactions of osteoblasts with structured titanium and the correlation between physicochemical characteristics and cell biological parameters.
abstract: Cellular behavior at the interface of an implant is influenced by the material's topography. However, little is known about the correlation between the biological parameters and the physicochemical characteristics of the biomaterial. We therefore modified pure titanium surfaces by polishing, machining, blasting with glass spheres, blasting with corundum particles, and vacuum plasma spraying to give progressively higher surface roughness. The material surface was characterized by SEM, surface profiling, and electrochemical methods. We revealed a correlation for integrin expression and formation, adhesion, spreading, proliferation, and bone sialo protein expression with the physicochemical parameters of the titanium surfaces.
authors: Department of Internal Medicine, University of Rostock, BMFZ, Schillingallee 69, D-18057 Rostock, Germany. barbara.nebe@med.uni-rostock.de
authors: J G Barbara
authors: JG
authors: Nebe
authors: Frank
authors: F
authors: Luethen
authors: Regina
authors: R
authors: Lange
authors: Ulrich
authors: U
authors: Beck
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D010006:Osteoblasts / Q000737:chemistry* / Q000378:metabolism; D019736:Prostheses and Implants / Q000648:ultrastructure; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry* / Q000378:metabolism
chemical_list: D001672:Biocompatible Materials; D014025:Titanium