Effects of the myeloperoxidase 463 gene polymorphisms on development of atrophy in H pylori infected or noninfected gastroduodenal disease.
OBJECTIVE
To investigate the relationship between myelo-peroxidase polymorphisms as a host-related factor and atrophy caused by H pylori.


METHODS
Our study enrolled 77 patients. Biopsy materials obtained during gastrointestinal endoscopies were evaluated for the presence of H pylori. Polymerase chain reaction-restriction fragment length polymorphism assay was used to characterize myeloperoxidase genotypes.


RESULTS
Forty four patients (57.1%) were Hp (+) and 33 (42.9%) were Hp (-). Sixty six (85.7%) had GG genotype, 10 (12.9%) had GA genotype and 1 (1.29%) had AA genotype. The change in atrophy in relation to neutrophil infiltration was significant in Hp (+) patients (P = 0.0001). The change in atrophy in relation to neutrophil infiltration in patients with GG genotype was significant (P = 0.002). However, the change in atrophy in relation to neutrophil infiltration was not significant in patients with Hp (+) GG genotype (r = 0.066, P = 0.63).


CONCLUSIONS
Myeloperoxidase genotype is critical for development of atrophy in relation to the severity of inflammation. However, it is interesting to note that, H pylori does not show any additive effect on development of atrophy.
Yilmaz
Omer
O
Department of Gastroenterology, University of Atatürk, Erzurum 25070, Turkey. yilmazo@atauni.edu.tr
Dursun
Hakan
H
Gürsan
Nesrin
N
Pirim
Ibrahim
I
Yilmaz
Arif
A
Okcu
Nihat
N
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005757:Gastritis, Atrophic / Q000201:enzymology / Q000209:etiology*; D016481:Helicobacter Infections / Q000150:complications* / Q000201:enzymology; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D008875:Middle Aged; D020556:Neutrophil Infiltration / Q000502:physiology*; D010437:Peptic Ulcer / Q000150:complications; D009195:Peroxidase / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic
D009195:Peroxidase