Chemical glycosylation in the synthesis of glycoconjugate antitumour vaccines.
Therapeutic vaccines derived from carbohydrate antigen-adjuvant combinations are a promising approach for cancer immunotherapy. One of the critical limitations in this area is access to sufficient quantities of tumour-associated carbohydrate antigens and glycoconjugate adjuvants. At present, availability of the complex oligosaccharide constructs that are needed for the systematic design and evaluation of novel vaccine formulations relies on de novo chemical synthesis. The use of both state-of-the-art and emerging glycosylation technologies has led to significant advances in this field, allowing the clinical exploration of carbohydrate-based antigens in the treatment of cancer.
Galonić
Danica P
DP
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA. danica_galonic@hms.harvard.edu
Gin
David Y
DY
D000276:Adjuvants, Immunologic / Q000138:chemical synthesis / Q000737:chemistry; D000818:Animals; D000951:Antigens, Neoplasm / Q000737:chemistry / Q000276:immunology; D019496:Cancer Vaccines / Q000138:chemical synthesis* / Q000737:chemistry* / Q000276:immunology; D002240:Carbohydrate Sequence; D006001:Glycoconjugates / Q000138:chemical synthesis* / Q000737:chemistry / Q000276:immunology; D006031:Glycosylation; D006801:Humans; D008969:Molecular Sequence Data
D000276:Adjuvants, Immunologic; D000951:Antigens, Neoplasm; D019496:Cancer Vaccines; D006001:Glycoconjugates