Primary ocular natural killer/T-cell lymphomas: clinicopathologic features and diagnosis.
OBJECTIVE
Primary ocular natural killer/T-cell lymphoma (NKTL) is rare. This study aims to characterize the clinical manifestations, diagnosis and treatment methods of primary ocular NKTL.


METHODS
Clinical data of seven patients with ocular NKTL from 1982 to 2004 were collected. A morphologic, immunohistochemical and molecular analysis was undertaken.


RESULTS
Clinical manifestations and computed tomography of the patients were typical. LCA CD56 CD3epsilon Ki-67 granzyme B (GrB) and T-cell intracellular antigen-1(TIA-1) were mostly positive. Clonal T-cell-receptor gene rearrangements of five patients showed negative findings, and the detection of Epstein-Barr virus showed positive. All patients died 5 months to 28 months after presentation.


CONCLUSIONS
Ocular NKTL is a highly aggressive clinical course with poor prognosis. The diagnosis relies on clinicopathologic findings.
Yang
Yuli
Y
Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu, China.
Luo
Qingli
Q
He
Weiming
W
Tang
Li
L
D000328:Adult; D014408:Biomarkers, Tumor / Q000378:metabolism; D017252:CD3 Complex / Q000378:metabolism; D019002:CD56 Antigen / Q000378:metabolism; D003131:Combined Modality Therapy; D004273:DNA, Neoplasm / Q000032:analysis; D003937:Diagnosis, Differential; D005500:Follow-Up Studies; D019675:Genes, T-Cell Receptor gamma / Q000235:genetics; D053804:Granzymes / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000378:metabolism; D007694:Killer Cells, Natural / Q000276:immunology / Q000473:pathology*; D016411:Lymphoma, T-Cell, Peripheral / Q000175:diagnosis / Q000276:immunology / Q000628:therapy; D008279:Magnetic Resonance Imaging; D008297:Male; D009918:Orbital Neoplasms / Q000175:diagnosis / Q000276:immunology / Q000628:therapy; D039102:Poly(A)-Binding Proteins / Q000378:metabolism; D016133:Polymerase Chain Reaction; D011379:Prognosis; D000074019:T-Cell Intracellular Antigen-1; D014057:Tomography, X-Ray Computed
D014408:Biomarkers, Tumor; D017252:CD3 Complex; D019002:CD56 Antigen; D004273:DNA, Neoplasm; D019394:Ki-67 Antigen; D039102:Poly(A)-Binding Proteins; D000074019:T-Cell Intracellular Antigen-1; C071558:TIA1 protein, human; D053804:Granzymes