title: N,N-dimethylsphingosine-coumarin: synthesis, chemical characterization, and biological evaluation.
abstract: Coumarin derivatives of N,N-dimethylsphingosine (DMSP) were prepared and chemically characterized. They were apparently biologically equivalent to DMSP in terms of tumor cell cytotoxicity and were used to establish the rapid mitochondrial localization of this sphingolipid in tumor cells, followed closely by its marked reduction of mitochondrial membrane potential.
authors: Departments of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA.
authors: Sukhen C
authors: SC
authors: Ghosh
authors: Edmond
authors: E
authors: Auzenne
authors: David
authors: D
authors: Farquhar
authors: Jim
authors: J
authors: Klostergaard
mesh_terms: D045744:Cell Line, Tumor; D003374:Coumarins / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology*; D006801:Humans; D053078:Membrane Potential, Mitochondrial / Q000187:drug effects; D008856:Microscopy, Fluorescence; D008928:Mitochondria / Q000737:chemistry / Q000378:metabolism*; D013110:Sphingosine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology
chemical_list: D003374:Coumarins; C030123:coumarin; C061800:N,N-dimethylsphingosine; D013110:Sphingosine