title: Leprosy-associated eccrine syringofibroadenoma of Mascaro.
abstract: Eccrine syringofibroadenoma of Mascaro is a rare benign tumour. There are five subtypes, one of which is known to occur in reaction to inflammatory and neoplastic dermatoses. We describe a patient with previous lepromatous leprosy presenting with multiple flesh-coloured verrucous plaques over the right foot. Histology was consistent with eccrine syringofibroadenoma. To our knowledge, this is the first reported case of multiple eccrine syringofibroadenomata occurring in association with leprosy. The tumours in this case are most likely reactive in nature, subsequent to multiple traumatic events with tissue remodelling in an insensate foot affected by leprosy. It is less probable that the tumours are a result of scarring from recurrent infections. We also raise the possibility of a neuroeccrine interaction, with sympathetic neuropathy in leprosy as a contributing factor in the pathogenesis.
authors: National Skin Center, Singapore. hltey@nsc.gov.sg
authors: H L
authors: HL
authors: Tey
authors: W S
authors: WS
authors: Chong
authors: S N
authors: SN
authors: Wong
mesh_terms: D006607:Adenoma, Sweat Gland / Q000209:etiology / Q000473:pathology*; D000367:Age Factors; D000368:Aged; D018450:Disease Progression; D004439:Eccrine Glands / Q000473:pathology*; D005260:Female; D018226:Fibroadenoma / Q000473:pathology*; D005500:Follow-Up Studies; D006801:Humans; D015440:Leprosy, Lepromatous / Q000150:complications*; D012878:Skin Neoplasms / Q000209:etiology / Q000473:pathology*; D013544:Sweat Gland Neoplasms / Q000209:etiology / Q000473:pathology*