title: Microsatellite instability in Bulgarian patients with endometrial cancer.
abstract: OBJECTIVE
  Microsatellite instability (MSI) is a frequent event in different types of cancer. In several studies MSI was shown to have both clinical and prognostic value. The aim of our study was to determine the frequency of MSI in Bulgarian patients with endometrial cancer (EC) and the possible relation of this phenomenon to their clinicopathological characteristics.
  
  
  METHODS
  A total of 33 histologically confirmed EC patients were analyzed for tumor MSI using a panel of 6 microsatellite markers.
  
  
  RESULTS
  We identified MSI in 30% of endometrial cancer cases. Six of them had high degree of MSI (MSI-H), and 4 displayed low degree of MSI (MSI-L).
  
  
  CONCLUSIONS
  The frequency of MSI in Bulgarian EC patients does not differ significantly from that reported in other European studies.
authors: Laboratory of Molecular Pathology, University Hospital of Obstetrics and Gynecology Maichin Dom, Sofia, Bulgaria. darivko@gmail.com
authors: D V
authors: DV
authors: Konstantinova
authors: T K
authors: TK
authors: Kadiyska
authors: R P
authors: RP
authors: Kaneva
authors: S I
authors: SI
authors: Ivanov
authors: R G
authors: RG
authors: Dimitrov
authors: T V
authors: TV
authors: Dyankova
authors: K P
authors: KP
authors: Meinhardt
authors: M V
authors: MV
authors: Gulubova
authors: T I
authors: TI
authors: Vlaykova
authors: N I
authors: NI
authors: Doganov
authors: V I
authors: VI
authors: Mitev
authors: I M
authors: IM
authors: Kremensky
mesh_terms: D000368:Aged; D002031:Bulgaria; D002454:Cell Differentiation; D016889:Endometrial Neoplasms / Q000235:genetics* / Q000473:pathology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D005838:Genotype; D006801:Humans; D053842:Microsatellite Instability; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D010641:Phenotype; D011379:Prognosis; D012189:Retrospective Studies