title: Nanoporous hard carbon membranes for medical applications.
abstract: Current blood glucose sensors have proven to be inadequate for long term in vivo applications; membrane biofouling and inflammation play significant roles in sensor instability. An ideal biosensor membrane material must prevent protein adsorption and promote integration of the sensor with the surrounding tissue. Furthermore, biosensor membranes must be sufficiently thin and porous in order to allow the sensor to rapidly respond to fluctuations in analyte concentration. In this study, the use of diamondlike carbon-coated anodized aluminum oxide as a potential biosensor membrane is discussed. Diamondlike carbon films and diamondlike carbon-coated anodized aluminum oxide nanoporous membranes were examined using scanning electron microscopy, atomic force microscopy, X-ray photoelectron spectroscopy, Raman spectroscopy, and platelet rich plasma testing. The diamondlike carbon-coated anodized aluminum oxide membranes remained free from protein adsorption during in vitro platelet rich plasma testing. We anticipate that this novel membrane could find use in immunoisolation devices, pacemakers, kidney dialysis membranes, microdialysis systems, and other devices facing biocompatibility issues that limit in vivo function.
authors: Department of Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
authors: Roger J
authors: RJ
authors: Narayan
authors: Chunming
authors: C
authors: Jin
authors: Nicola
authors: N
authors: Menegazzo
authors: Boris
authors: B
authors: Mizaikoff
authors: Rosario A
authors: RA
authors: Gerhardt
authors: Melanie
authors: M
authors: Andara
authors: Arvind
authors: A
authors: Agarwal
authors: Chun-Che
authors: CC
authors: Shih
authors: Chun-Ming
authors: CM
authors: Shih
authors: Shing-Jong
authors: SJ
authors: Lin
authors: Yea-Yang
authors: YY
authors: Su
mesh_terms: D000327:Adsorption; D000537:Aluminum Oxide / Q000737:chemistry; D001672:Biocompatible Materials / Q000737:chemistry*; D015374:Biosensing Techniques; D002244:Carbon / Q000737:chemistry*; D004563:Electrochemistry / Q000379:methods; D004867:Equipment Design; D008422:Materials Testing; D008566:Membranes / Q000737:chemistry; D008855:Microscopy, Electron, Scanning; D036103:Nanotechnology / Q000379:methods*; D037742:Nanotubes, Carbon / Q000737:chemistry*; D013059:Spectrum Analysis, Raman
chemical_list: D001672:Biocompatible Materials; D037742:Nanotubes, Carbon; D002244:Carbon; D000537:Aluminum Oxide