Antiproliferative effects of some N-benzylideneanilines.
A series of Schiff bases including N-benzylideneaniline (NBA) nuclei were prepared. The chemical products obtained were characterized by mass spectometry (APCI), 1H NMR, and IR spectroscopy in order to seek their cytotoxic and proliferation effects on human small lung (A549) and cervical (HeLa) cancer cell lines with biochemical assays. All of the synthesized compounds showed antiproliferative effects to different extents.
Ozkay
Yusuf
Y
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, 26470 Eskişehir, Turkey.
Incesu
Zerrin
Z
Işikdağ
Ilhan
I
Yeşilkaya
Mehmet
M
D000814:Aniline Compounds / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001597:Benzylidene Compounds / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006131:Growth Inhibitors / Q000494:pharmacology*; D006367:HeLa Cells; D006801:Humans; D012545:Schiff Bases / Q000494:pharmacology; D013997:Time Factors
D000814:Aniline Compounds; D000970:Antineoplastic Agents; D001597:Benzylidene Compounds; D006131:Growth Inhibitors; D012545:Schiff Bases; C023650:aniline