title: Influence of water quality on cholesterol induced systemic pathology.
abstract: Reduced systemic pathology was identified in cholesterol-fed rabbits administered distilled water compared to animals drinking local tap water; this included pathology of the liver and spleen. Studies directed at determining the effect of the trace metals aluminum, copper and zinc on cholesterol-induced systemic pathology were undertaken. As previously reported copper added to distilled drinking water (0.12 PPM) increased Alzheimer-like pathology in the brain, but did not augment pathology of the spleen or liver. Aluminum added to distilled water (0.36 PPM) administered to drink exacerbated cholesterol-induced hepatic pathology but not splenic pathology, and addition of 0.36 PPM zinc to the distilled drinking water failed to affect pathology of either the liver or spleen. The overall increase in both central and systemic pathology observed among cholesterol-fed rabbits administered tap water seems to be due to different trace metal contaminants occurring in tap water.
authors: Cleo Roberts Center for Clinical Research, Sun Health Research Insititute, Sun City, AZ.
authors: D L
authors: DL
authors: Sparks
authors: T
authors: T
authors: Martin
authors: G
authors: G
authors: Stankovic
authors: T
authors: T
authors: Wagoner
authors: R
authors: R
authors: Van Andel
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism; D000818:Animals; D002784:Cholesterol / Q000378:metabolism; D002791:Cholesterol, Dietary / Q000008:administration & dosage; D003300:Copper / Q000008:administration & dosage / Q000009:adverse effects / Q000032:analysis; D004195:Disease Models, Animal; D004326:Drinking; D006801:Humans; D006937:Hypercholesterolemia / Q000378:metabolism; D008099:Liver / Q000473:pathology*; D008297:Male; D011817:Rabbits; D013154:Spleen / Q000473:pathology*; D014867:Water / Q000592:standards*; D014874:Water Pollutants, Chemical / Q000008:administration & dosage / Q000009:adverse effects*; D015032:Zinc / Q000008:administration & dosage / Q000009:adverse effects / Q000032:analysis
chemical_list: D002791:Cholesterol, Dietary; D014874:Water Pollutants, Chemical; D014867:Water; D003300:Copper; D002784:Cholesterol; D015032:Zinc