[Recent advances on the role of chemokines/chemokine receptors in the pathogenesis of idiopathic pulmonary fibrosis].
Idiopathic pulmonary fibrosis (IPF) is a progressive and irreversible lung disease characterized by fibrosis in the lung parenchyma and collagen deposition leading to respiratory failure. Different etiopathogenetic hypothesis have been formulated during the last years and many studies recently published demonstrated that in most of processes suggested for the onset and the development of IPF, chemokines and chemokine receptors are involved. Dysregulated expression of chemokines and their receptors during inflammatory processes might also alter the equilibrium between angiostatic and angiogenic processes leading to neovascularization in the lung tissue. Studies on chemokines/chemokine receptors could shed light on the mechanisms involved in IPF and draw new therapeutic strategies to block the progression of the disease.
Brunetti
Giuseppe
G
Divisione di Pneumologia Riabilitativa, Fondazione Salvatore Maugeri, IRCCS Istituto Scientifico, Pavia. gbrunetti@fsm.it
Pignatti
Patrizia
P
D020533:Angiogenesis Inhibitors / Q000627:therapeutic use; D001706:Biopsy; D018925:Chemokines / Q000037:antagonists & inhibitors / Q000502:physiology*; D018450:Disease Progression; D005347:Fibroblasts / Q000473:pathology; D006801:Humans; D007371:Interferon-gamma / Q000627:therapeutic use; D008024:Ligands; D008168:Lung / Q000473:pathology; D009389:Neovascularization, Pathologic; D011658:Pulmonary Fibrosis / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D016032:Randomized Controlled Trials as Topic; D019707:Receptors, Chemokine / Q000037:antagonists & inhibitors / Q000502:physiology*; D011994:Recombinant Proteins
D020533:Angiogenesis Inhibitors; D018925:Chemokines; D008024:Ligands; D019707:Receptors, Chemokine; D011994:Recombinant Proteins; D007371:Interferon-gamma