[Clinical observation on effect of compound Shiwei Tablet in treating urinary tract infection].
OBJECTIVE
To evaluate the safety and efficacy of Compound Shiwei Tablet (CST) in treating upper and lower urinary tract infection (UTI, pyretic stranguria of dampness-heat of the Lower-jiao type in 'TCM).


METHODS
A multi-center, randomized, and opened clinical trial was conducted in the UTI patients with Sanjin Tablet (ST) as the parallel positive control medicine. The comprehensive efficacy, effect on TCM syndrome score, and change of urinary leukocyte count were observed, and the adverse reaction was recorded.


RESULTS
In the 147 upper UTI cases and the 312 lower UTI cases after treatment, the comprehensive effect was higher and urinary leukocyte was less in the CST treated patients than in the ST treated patients (P < 0.05); but significant difference in the improvement of TCM symptoms was found between them only in the lower UTI cases ( P < 0.05); and no adverse reaction was observed during the treatment course.


CONCLUSIONS
CST has definite therapeutic efficacy on UTI and is safe in clinical application.
Zhan
Yong-li
YL
Department of Nephrology, Guang' anmen Hospital Affiliated to China Academy of Chinese Medical Sciences, Beijing. zhanyongli88@sina.com
Li
Xiu-ying
XY
Wu
Sheng-xian
SX
D000328:Adult; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008516:Medicine, Chinese Traditional; D008875:Middle Aged; D008517:Phytotherapy; D013577:Syndrome; D013607:Tablets; D016896:Treatment Outcome; D014527:Uric Acid / Q000652:urine; D014552:Urinary Tract Infections / Q000175:diagnosis / Q000188:drug therapy* / Q000652:urine
D004365:Drugs, Chinese Herbal; D013607:Tablets; C528583:shiwei; D014527:Uric Acid