Fast and sensitive trace analysis of malachite green using a surface-enhanced Raman microfluidic sensor.
A rapid and highly sensitive trace analysis technique for determining malachite green (MG) in a polydimethylsiloxane (PDMS) microfluidic sensor was investigated using surface-enhanced Raman spectroscopy (SERS). A zigzag-shaped PDMS microfluidic channel was fabricated for efficient mixing between MG analytes and aggregated silver colloids. Under the optimal condition of flow velocity, MG molecules were effectively adsorbed onto silver nanoparticles while flowing along the upper and lower zigzag-shaped PDMS channel. A quantitative analysis of MG was performed based on the measured peak height at 1615 cm(-1) in its SERS spectrum. The limit of detection, using the SERS microfluidic sensor, was found to be below the 1-2 ppb level and this low detection limit is comparable to the result of the LC-Mass detection method. In the present study, we introduce a new conceptual detection technology, using a SERS microfluidic sensor, for the highly sensitive trace analysis of MG in water.
Lee
Sangyeop
S
Department of Applied Chemistry, Hanyang University, Ansan 426-791, South Korea.
Choi
Junghyun
J
Chen
Lingxin
L
Park
Byungchoon
B
Kyong
Jin Burm
JB
Seong
Gi Hun
GH
Choo
Jaebum
J
Lee
Yeonjung
Y
Shin
Kyung-Hoon
KH
Lee
Eun Kyu
EK
Joo
Sang-Woo
SW
Lee
Kyeong-Hee
KH
D046210:Microfluidic Analytical Techniques / Q000379:methods*; D012394:Rosaniline Dyes / Q000032:analysis*; D013059:Spectrum Analysis, Raman / Q000379:methods*
D012394:Rosaniline Dyes; C005095:malachite green