[Iron metabolism in biological systems (biochemical, pathophysiological and clinical aspects)].
Modern concepts concerning iron metabolisms in the body, its circulation, involvement into free radical processes and lipid peroxidation (LP) are reviewed. Spetial attention is paid to cytotoxic effects, Fe2+ influence on lipid peroxidation, its role in multiple organ failure development in critical states. Iron ion can be bound by desferal, which may be effectively used for intensive care of critical states.
Orlov
Iu P
IuP
Dolgikh
V T
VT
D000975:Antioxidants / Q000627:therapeutic use; D016638:Critical Illness; D003676:Deferoxamine / Q000627:therapeutic use; D005609:Free Radicals / Q000378:metabolism; D006801:Humans; D000860:Hypoxia / Q000378:metabolism; D007501:Iron / Q000378:metabolism*; D035925:Iron-Regulatory Proteins / Q000502:physiology; D015227:Lipid Peroxidation; D009102:Multiple Organ Failure / Q000188:drug therapy / Q000378:metabolism*; D010084:Oxidation-Reduction; D017262:Siderophores / Q000627:therapeutic use
D000975:Antioxidants; D005609:Free Radicals; D035925:Iron-Regulatory Proteins; D017262:Siderophores; D007501:Iron; D003676:Deferoxamine