[Management of localized germ-cell tumours of the testis].
Stage 1 is currently the most frequent pattern at diagnosis of germ-cell tumours. Prognosis is excellent and different options are available after orchidectomy. The therapeutic choice should be taken after fair and extensive information regarding the limitations of each option therefore taking into account both predictive factors of relapse and patient individual willing. In case of pure seminoma, prophylactic radiotherapy directed to the retroperitoneal lymph nodes, chemotherapy by single-agent carboplatin and surveillance with differed treatment at relapse are the three currently available attitudes. In non-seminomatous germ cell tumours three options should also be considered: surveillance (watchful waiting), chemotherapy by two cycles of BEP, or retroperitoneal lymph node dissection.
Loriot
Yohann
Y
Département de médecine, institut Gustave-Roussy, Villejuif Cedex.
Fizazi
Karim
K
D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use; D001761:Bleomycin / Q000008:administration & dosage / Q000627:therapeutic use; D016190:Carboplatin / Q000008:administration & dosage / Q000627:therapeutic use; D017024:Chemotherapy, Adjuvant; D002945:Cisplatin / Q000008:administration & dosage / Q000627:therapeutic use; D002985:Clinical Protocols; D017326:Clinical Trials, Phase III as Topic; D003131:Combined Modality Therapy; D005047:Etoposide / Q000008:administration & dosage / Q000627:therapeutic use; D005500:Follow-Up Studies; D006801:Humans; D008197:Lymph Node Excision; D008297:Male; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D009373:Neoplasms, Germ Cell and Embryonal / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D009919:Orchiectomy; D017410:Practice Guidelines as Topic; D011379:Prognosis; D011879:Radiotherapy Dosage; D016032:Randomized Controlled Trials as Topic; D018239:Seminoma / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy / Q000628:therapy; D013736:Testicular Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D013737:Testis / Q000473:pathology; D013995:Time; D013997:Time Factors
D000970:Antineoplastic Agents; D001761:Bleomycin; D005047:Etoposide; D016190:Carboplatin; D002945:Cisplatin