[Extrusion/spheronization: an important method for the production of the pellet dosage form].
Extrusion/spheronization is the method used to manufacture pellets with a high content of the active ingredient. It produces particles of very good physical properties (strength, friability, porosity, density, uniform diameter), which are well processed in further steps, i.e., when they are coated, compressed or filled into hard gelatine capsules. The process of extrusion/spheroniztion consists of several consequential steps, which are influenced by numerous formulation and process factors. Though there are general rules for optimization of the process, due to its complexity the same rules need not necessarily be valid for similar systems and very often it is necessary to find again the optimal production condition for a new formulation and equipment. The paper informs about the technology, equipment, and the result achieved in the field.
Häring
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Veterinární a farmaceutická univerzita Brno, Farmaceutická fakulta, Ustav technologie léků.
Rabisková
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D002214:Capsules; D010316:Particle Size; D013678:Technology, Pharmaceutical
D002214:Capsules