title: Zuclopenthixol-induced neuroleptic malignant syndrome in an adolescent girl.
abstract: We present the case of a 14-year-old female who had many characteristics of neuroleptic malignant syndrome (NMS) without pyrexia following a single depot injection of 200 mg of zuclopenthixol. The patient presented with a change in mental status that had progressed over the preceding 48 hours. Subsequently, she became increasingly agitated and confused, and developed diffuse muscular rigidity, mutism, tremor, tachycardia, diaphoresis, sialorrhea, and incontinence. Results of laboratory tests showed elevated CPK levels, leukocytosis, and a low serum iron level. Bromocriptine and diazepam were used as initial treatment of a probable NMS and provided significant improvement. During the next seven days, she clinically improved but continued to exhibit emotional lability, logorrhea, elevated mood, and increased psychomotor activity. Therefore, bromocriptine and diazepam were discontinued and lorazepam and lithium were administered as treatment of a bipolar disorder. Four weeks later, she was discharged in stable condition. The presentation of this case report suggests that the primary psychiatric diagnosis is important in antipsychotic usage in the pediatric population, and that young patients receiving neuroleptic treatment should be monitored for the early signs of NMS. Using the diagnostic criteria of a neuroleptic toxicity spectrum may result in greater clinical awareness and earlier recognition of NMS.
authors: Department of Child Psychiatry, Ege University, School of Medicine, Izmir, Turkey.
authors: Serpil
authors: S
authors: Erermis
authors: Tezan
authors: T
authors: Bildik
authors: Muge
authors: M
authors: Tamar
authors: Ahmet
authors: A
authors: Gockay
authors: Hatice
authors: H
authors: Karasoy
authors: Eyup Sabri
authors: ES
authors: Ercan
mesh_terms: D000293:Adolescent; D014151:Anti-Anxiety Agents / Q000627:therapeutic use; D000931:Antidotes / Q000627:therapeutic use; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000506:poisoning*; D001971:Bromocriptine / Q000627:therapeutic use; D003006:Clopenthixol / Q000008:administration & dosage / Q000506:poisoning*; D003692:Delayed-Action Preparations; D003975:Diazepam / Q000627:therapeutic use; D018491:Dopamine Agonists / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000627:therapeutic use; D007273:Injections, Intramuscular; D018020:Lithium Compounds / Q000627:therapeutic use; D008140:Lorazepam / Q000627:therapeutic use; D009459:Neuroleptic Malignant Syndrome / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology*; D016896:Treatment Outcome
chemical_list: D014151:Anti-Anxiety Agents; D000931:Antidotes; D014150:Antipsychotic Agents; D003692:Delayed-Action Preparations; D018491:Dopamine Agonists; D006993:Hypnotics and Sedatives; D018020:Lithium Compounds; D001971:Bromocriptine; D003006:Clopenthixol; D008140:Lorazepam; D003975:Diazepam