alpha-Glucosidase inhibitory constituents from stem bark of Terminalia superba (Combretaceae).
The CH(2)Cl(2)/CH(3)OH (1/1) extract of the dried stem bark of Terminalia superba afforded two compounds, (7S,8R,7'R,8'S)-4'-hydroxy-4-methoxy-7,7'-epoxylignan and meso-(rel 7S,8R,7'R,8'S)-4,4'-dimethoxy-7,7'-epoxylignan along with 11 known compounds. The structures of the compounds were established by analysing the spectroscopic data and also comparing it with the data of previously known analogues. All the isolated compounds were evaluated for their glycosidase inhibition activities. Gallic acid and methyl gallate showed significant alpha-glucosidase inhibition activity.
Wansi
Jean Duplex
JD
Department of Chemistry, University of Douala, Faculty of Science, P.O. Box 24157, Douala, Cameroon. jdwansi@yahoo.fr
Lallemand
Marie-Christine
MC
Chiozem
David Daco
DD
Toze
Flavien Aristide A
FA
Mbaze
Luc Meva'a
LM
Naharkhan
Shamsun
S
Iqbal
Muhammad Choudhary
MC
Tillequin
François
F
Wandji
Jean
J
Fomum
Zacharias Tanee
ZT
D004791:Enzyme Inhibitors / Q000302:isolation & purification / Q000494:pharmacology; D065089:Glycoside Hydrolase Inhibitors; D017705:Lignans / Q000302:isolation & purification / Q000494:pharmacology; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology; D018547:Plant Stems / Q000737:chemistry; D029766:Terminalia / Q000737:chemistry*
D004791:Enzyme Inhibitors; D065089:Glycoside Hydrolase Inhibitors; D017705:Lignans; D010936:Plant Extracts