[Inhibition of bacterial lypopolysaccharide-induced inflammation by oxidized lipids].
Previous studies demonstrated that oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine inhibits inflammatory effects of the bacterial lipopolisacharide (LPS, endotoxin). In this work we have characterized the anti-endotoxin activity of other classes of oxidized phospholipids with different polar head groups and fatty acid residues. LPS-induced expression of E-selectin on human endothelial cells was inhibited by oxidized phosphatidylcholine, phosphatidylserine, phosphatidylethanolamine, and phosphatidic acids. The anti-endotoxin effect insignificantly depended on the type of polyunsaturated fatty acids. Unoxidized phospholipids did not suppress effects of LPS. Thus, the anti-endotoxin activity of oxidized phospholipids crucially depends on the presence of oxidatively modified fatty acid residue.
Korotaeva
A A
AA
Samokhodskaia
L M
LM
Bochkov
V N
VN
D002478:Cells, Cultured; D019040:E-Selectin / Q000096:biosynthesis; D042783:Endothelial Cells / Q000187:drug effects / Q000378:metabolism; D004730:Endothelium, Vascular / Q000166:cytology; D004926:Escherichia coli; D006801:Humans; D007249:Inflammation / Q000378:metabolism / Q000517:prevention & control*; D008070:Lipopolysaccharides / Q000494:pharmacology*; D010084:Oxidation-Reduction; D010743:Phospholipids / Q000627:therapeutic use*; D013329:Structure-Activity Relationship; D014471:Umbilical Veins / Q000166:cytology
D019040:E-Selectin; D008070:Lipopolysaccharides; D010743:Phospholipids