Synthetic approaches to the 2005 new drugs.
New drugs are introduced to the market every year and each individual drug represents a privileged structure for its biological target. In addition, these new chemical entities (NCEs) not only provide insights into molecular recognition, but also serve as drug-like leads for designing future new drugs. To these ends, this review covers the syntheses of 22 NCEs marketed in 2005.
Sakya
Subas M
SM
Pfizer Global Research and Development, Pfizer, Inc., Groton, CT 06340, USA. subas.m.sakya@pfizer.com
Li
Jin
J
Liu
Kevin K-C
KK
D015195:Drug Design; D015394:Molecular Structure; D004364:Pharmaceutical Preparations / Q000145:classification*
D004364:Pharmaceutical Preparations