Functional significance of Na+/Ca2+ exchangers co-localization with ryanodine receptors.
Co-localization of Na+/Ca2+ exchangers (NCX) with ryanodine receptors (RyRs) is debated. We incorporate local NCX current in a biophysically detailed model of L-type Ca2+ channels (LCCs) and RyRs and study the effect of NCX on the regulation of Ca2+-induced Ca2+ release and the shape of the action potential. In canine ventricular cells, under pathological conditions, e.g., impaired LCCs, local NCXs become an enhancer of sarcoplasmic reticulum release. Under such conditions incorporation of local NCXs is critical to accurately capture mechanisms of excitation-contraction coupling.
Sher
Anna A
AA
Computational Biology Group, University of Oxford Computing Laboratory, Wolfson Building, Parks Road, Oxford OX1 3QD, Oxford, UK.
Hinch
Robert
R
Noble
Penelope J
PJ
Gavaghan
David J
DJ
Noble
Denis
D
D000818:Animals; D008962:Models, Theoretical; D019837:Ryanodine Receptor Calcium Release Channel / Q000378:metabolism*; D019831:Sodium-Calcium Exchanger / Q000378:metabolism*
D019837:Ryanodine Receptor Calcium Release Channel; D019831:Sodium-Calcium Exchanger