title: Plasmodium falciparum-infected mice: more than a tour de force.
abstract: Up until recently, the relevance of Plasmodium falciparum-infected humanized mice for malaria studies has been questioned because of the low percentage of mice in which the parasite develops. Advances in the generation of new immunodeficient mouse strains combined with the use of protocols that modulate the innate immune defenses of mice have facilitated the harvesting of exoerythrocytic and intraerythrocytic stages of the parasite. These results renew the hope of working with P. falciparum in a laboratory animal and indicate that the next challenge (i.e. a complete parasite cycle in the same mouse, including transmission to mosquito) could be reached in the future.
authors: Université Pierre & Marie Curie-Paris 6, UMR S511, Paris F-75013, France. ams@isciii.es
authors: Alicia
authors: A
authors: Moreno
authors: Jean Louis
authors: JL
authors: Pérignon
authors: Serban
authors: S
authors: Morosan
authors: Dominique
authors: D
authors: Mazier
authors: Agustin
authors: A
authors: Benito
mesh_terms: D000818:Animals; D002678:Chimera; D004195:Disease Models, Animal; D004912:Erythrocytes / Q000469:parasitology; D006801:Humans; D016778:Malaria, Falciparum / Q000469:parasitology / Q000503:physiopathology*; D051379:Mice; D016688:Mice, Inbred NOD; D016513:Mice, SCID; D010963:Plasmodium falciparum / Q000472:pathogenicity*