title: miR-1-2 gets to the heart of the matter.
abstract: Although many microRNAs (miRNAs) and their targets have been identified, the importance of miRNAs in vivo is still unclear. In this issue, Zhao et al. (2007) generate mice deficient in a cardiac-specific miRNA, miR-1-2, and reveal that this microRNA plays a crucial role in heart development and physiology.
authors: Department of Genetics, Yale University School of Medicine, New Haven, CT 06510, USA.
authors: Yuichiro
authors: Y
authors: Mishima
authors: Carlos
authors: C
authors: Stahlhut
authors: Antonio J
authors: AJ
authors: Giraldez
mesh_terms: D000818:Animals; D006321:Heart / Q000196:embryology* / Q000502:physiology*; D051379:Mice; D035683:MicroRNAs / Q000235:genetics / Q000502:physiology*
chemical_list: D035683:MicroRNAs