Synthesis and erosion properties of PEG-containing polyanhydrides.
To tailor the erosion rate of polyanhydrides while retaining their surface erosion characteristics, new three-component polyanhydrides of sebacic acid, 1,3-bis(p-carboxyphenoxy)propane and poly(ethylene glycol) were synthesized. The hydrophilicity of the polymer increased and its mechanical strength decreased with increasing PEG content. Correspondingly, the erosion rate increases with increasing PEG content, whereas it decreases with increasing specimen thickness. This indicates that the incorporation of poly(ethylene glycol) into traditional two-component polyanhydrides retains their surface erosion properties while making the erosion rate tunable. The new polyanhydrides hold potential for drug delivery applications.
Hou
Sijian
S
Department of Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI 48109, USA.
McCauley
Laurie K
LK
Ma
Peter X
PX
D001672:Biocompatible Materials / Q000737:chemistry*; D003652:Decanoic Acids / Q000737:chemistry*; D003998:Dicarboxylic Acids / Q000737:chemistry*; D016503:Drug Delivery Systems; D062425:Hydroxybenzoate Ethers; D062385:Hydroxybenzoates / Q000737:chemistry*; D010281:Parathyroid Hormone / Q000008:administration & dosage; D049388:Polyanhydrides / Q000737:chemistry*; D011092:Polyethylene Glycols
D001672:Biocompatible Materials; D003652:Decanoic Acids; D003998:Dicarboxylic Acids; D062425:Hydroxybenzoate Ethers; D062385:Hydroxybenzoates; D010281:Parathyroid Hormone; D049388:Polyanhydrides; C078320:1,3-bis(4-carboxyphenoxy)propane; D011092:Polyethylene Glycols; C011107:sebacic acid