title: Synthesis of amphiphilic galactopyranosyl diamines and amino alcohols as antitubercular agents.
abstract: Mono- and diacylated derivatives of galactopyranosyl amines were obtained from d-galactose, via aminated intermediates prepared by reaction of 6-deoxy-6-iodo-1,2:3,4-di-O-isopropylidene-alpha-d-galactopyranose with 1,3-propanediamine, 1,2-ethanediamine or ethanolamine. Monoacylated derivatives displayed antitubercular activity.
authors: Departamento de Química, Universidade Federal de Juiz de Fora, Juiz de Fora-MG 36036-330, Brazil. mauro.almeida@ufif.edu.br
authors: Mauro Vieira
authors: MV
authors: de Almeida
authors: Mireille
authors: M
authors: Le Hyaric
authors: Giovanni Wilson
authors: GW
authors: Amarante
authors: Maria Cristina
authors: MC
authors: Silva Lourenço
authors: Marcelo Luiz
authors: ML
authors: Lima Brandão
mesh_terms: D000215:Acylation; D000605:Amino Alcohols / Q000138:chemical synthesis* / Q000494:pharmacology; D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D003959:Diamines / Q000138:chemical synthesis / Q000494:pharmacology; D005688:Galactosamine / Q000138:chemical synthesis* / Q000494:pharmacology; D015394:Molecular Structure; D013329:Structure-Activity Relationship
chemical_list: D000605:Amino Alcohols; D000995:Antitubercular Agents; D003959:Diamines; D005688:Galactosamine