Interface interactions of osteoblasts with structured titanium and the correlation between physicochemical characteristics and cell biological parameters.
Cellular behavior at the interface of an implant is influenced by the material's topography. However, little is known about the correlation between the biological parameters and the physicochemical characteristics of the biomaterial. We therefore modified pure titanium surfaces by polishing, machining, blasting with glass spheres, blasting with corundum particles, and vacuum plasma spraying to give progressively higher surface roughness. The material surface was characterized by SEM, surface profiling, and electrochemical methods. We revealed a correlation for integrin expression and formation, adhesion, spreading, proliferation, and bone sialo protein expression with the physicochemical parameters of the titanium surfaces.
Nebe
J G Barbara
JG
Department of Internal Medicine, University of Rostock, BMFZ, Schillingallee 69, D-18057 Rostock, Germany. barbara.nebe@med.uni-rostock.de
Luethen
Frank
F
Lange
Regina
R
Beck
Ulrich
U
D001672:Biocompatible Materials / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D010006:Osteoblasts / Q000737:chemistry* / Q000378:metabolism; D019736:Prostheses and Implants / Q000648:ultrastructure; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry* / Q000378:metabolism
D001672:Biocompatible Materials; D014025:Titanium