Improved temporal clustering analysis method applied to whole-brain data in acupuncture fMRI study.
Temporal clustering analysis (TCA) has been proposed as a method for detecting the brain responses of a functional magnetic resonance imaging (fMRI) time series when the time and location of activation are completely unknown. But TCA is not suitable for treating the time series of the whole brain due to the existence of many inactive pixels. In theory, active pixels are located only in gray matter (GM). In this study, SPM2 was used to segment functional images into GM, white matter and cerebrospinal fluid, and only the pixels in GM were considered. Thus, most of inactive pixels are deleted, so that the sensitivity of TCA is greatly improved in the analysis of the whole brain. The same set of acupuncture fMRI data was treated using both conventional TCA and modified TCA (MTCA) for comparing their analytical ability. The results clearly show a significant improvement in the sensitivity achieved by MTCA.
Lu
Na
N
Key Laboratory of Nuclear Analysis Techniques, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China.
Shan
Bao-Ci
BC
Xu
Jian-Yang
JY
Wang
Wei
W
Li
Kun-Cheng
KC
D015670:Acupuncture Therapy / Q000379:methods*; D000465:Algorithms; D001185:Artificial Intelligence; D001921:Brain / Q000033:anatomy & histology / Q000502:physiology*; D001931:Brain Mapping / Q000379:methods; D016000:Cluster Analysis; D005071:Evoked Potentials / Q000502:physiology*; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D010363:Pattern Recognition, Automated / Q000379:methods; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity