[Vitamin D and breast cancer].
Active vitamin D increases the differentiation and exerts antiproliferative effects in cancer cells. Recent data suggest that vitamin D is activated locally in cancer cells. Ecologic studies have shown an inverse correlation between breast cancer mortality and sun exposure and dietary vitamin D intake. In clinical studies an impaired vitamin D status is associated with a 20-30% increased breast cancer incidence and 10-20% increased mortality. As vitamin D insufficiency is common, it is important to clarify whether vitamin D status affects the risk and prognosis of breast cancer.
Nielsen
Lars Rejnmark
LR
Arhus Universitetshospital, Arhus Sygehus, Medicinsk-endokrinologisk Afdeling C. rejnmark@post6.tele.dk
Mosekilde
Leif
L
D001943:Breast Neoplasms / Q000209:etiology / Q000378:metabolism* / Q000401:mortality; D002112:Calcifediol / Q000008:administration & dosage / Q000172:deficiency / Q000378:metabolism; D002117:Calcitriol / Q000008:administration & dosage / Q000172:deficiency / Q000378:metabolism; D019317:Evidence-Based Medicine; D005260:Female; D006801:Humans; D012307:Risk Factors; D014466:Ultraviolet Rays; D014807:Vitamin D / Q000008:administration & dosage / Q000378:metabolism*; D014808:Vitamin D Deficiency / Q000150:complications
D014807:Vitamin D; D002117:Calcitriol; D002112:Calcifediol