title: Multilevel finite element modeling for the prediction of local cellular deformation in bone.
abstract: The underlying mechanisms by which bone cells respond to mechanical stimuli or how mechanical loads act on osteocytes housed in lacunae in bone are not well understood. In this study, a multilevel finite element (FE) approach is applied to predict local cell deformations in bone tissue. The local structure of the matrix dictates the local mechanical environment of an osteocyte. Cell deformations are predicted from detailed linear FE analysis of the microstructure, consisting of an arrangement of cells embedded in bone matrix material. This work has related the loads applied to a whole femur during the stance phase of the gait cycle to the strain of a single lacuna and of canaliculi. The predicted bone matrix strains around osteocyte lacunae and canaliculi were nonuniform and differed significantly from the macroscopically measured strains. Peak stresses and strains in the walls of the lacuna were up to six times those in the bulk extracellular matrix. Significant strain concentrations were observed at sites where the process meets the cell body.
authors: Laboratory of Biomechanics and Biomedical Engineering, Department of Mechanical Engineering and Aeronautics, University of Patras, Rion, 26500, Greece. deligian@mech.upatras.gr
authors: D D
authors: DD
authors: Deligianni
authors: C A
authors: CA
authors: Apostolopoulos
mesh_terms: D016880:Anisotropy; D019245:Compressive Strength / Q000502:physiology; D003198:Computer Simulation; D004548:Elasticity; D005269:Femur / Q000166:cytology* / Q000502:physiology*; D020342:Finite Element Analysis; D040542:Mechanotransduction, Cellular / Q000502:physiology*; D008954:Models, Biological; D010006:Osteoblasts / Q000502:physiology*; D013314:Stress, Mechanical; D016474:Weight-Bearing / Q000502:physiology*