title: Selective and potent in vitro antimalarial activities found in four microbial metabolites.
abstract: Antimalarial activities have been identified in four microbial metabolites through a screening programme of existing compounds in the Kitasato Institute chemical library. Hedamycin showed selective and potent activity against both drug-resistant and drug-sensitive strains of Plasmodium falciparum. Simaomicin alpha exhibited remarkably strong antimalarial activity, although its activity against a drug-resistant strain was weaker than that against a drug-sensitive strain. The antimalarial effects of triacsins C and D are also reported.
authors: Hideaki
authors: H
authors: Ui
authors: Aki
authors: A
authors: Ishiyama
authors: Hitomi
authors: H
authors: Sekiguchi
authors: Miyuki
authors: M
authors: Namatame
authors: Aki
authors: A
authors: Nishihara
authors: Yoko
authors: Y
authors: Takahashi
authors: Kazuro
authors: K
authors: Shiomi
authors: Kazuhiko
authors: K
authors: Otoguro
authors: Satoshi
authors: S
authors: Omura
mesh_terms: D000818:Animals; D000880:Anthraquinones / Q000737:chemistry / Q000494:pharmacology*; D000962:Antimalarials / Q000494:pharmacology*; D004351:Drug Resistance; D007546:Isoquinolines / Q000737:chemistry / Q000494:pharmacology*; D021261:Parasitic Sensitivity Tests; D010963:Plasmodium falciparum / Q000187:drug effects*; D014226:Triazenes / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000880:Anthraquinones; D000962:Antimalarials; D007546:Isoquinolines; D014226:Triazenes; C066125:simaomicin alpha; C001328:hedamycin; C034613:triacsin C; C034614:triacsin D