title: Early growth of infants of HIV-infected and uninfected Zambian women.
abstract: OBJECTIVE
  Parental HIV infection may affect even those exposed children who remain uninfected. We investigated early growth, an indicator of overall health, of infants born to Zambian mothers recruited for a study of breastfeeding and postpartum health.
  
  
  METHODS
  HIV-infected and uninfected women in Lusaka were followed regularly from late pregnancy to 16 weeks postpartum. Infant weight and length were measured at birth, 6 and 16 weeks. Infant HIV status could not be specifically determined in this cohort so comparisons were between all infants of HIV-uninfected mothers (n = 184) and those infants of HIV-infected mothers who were known to be alive and showed no clinical evidence of HIV infection at age 2-4 years (n = 85).
  
  
  RESULTS
  Most infants were exclusively or predominantly breastfed until 16 weeks. At all time points infants of HIV-infected mothers tended to have lower weight and length standard deviation (Z) scores (significant for weight at 6 weeks; P = 0.04), even after adjustment for their lower gestational age at birth, compared with infants of uninfected mothers. In multivariate analyses the major factors affecting weight or length at 6 or 16 weeks of age were birth weight or length, and maternal subclinical mastitis, primiparity and weight during pregnancy.
  
  
  CONCLUSIONS
  Early growth of infants of HIV-infected mothers is less than that of uninfected mothers, in part associated with subclinical mastitis, and this effect cannot be overcome with intensive support of mothers to follow international recommendations regarding exclusive breastfeeding.
authors: Lusaka District Health Management Team, Lusaka, Zambia.
authors: M
authors: M
authors: Makasa
authors: L
authors: L
authors: Kasonka
authors: M
authors: M
authors: Chisenga
authors: M
authors: M
authors: Sinkala
authors: C
authors: C
authors: Chintu
authors: A
authors: A
authors: Tomkins
authors: S
authors: S
authors: Filteau
mesh_terms: D000328:Adult; D001724:Birth Weight / Q000502:physiology; D001827:Body Height / Q000502:physiology; D001835:Body Weight / Q000502:physiology; D001942:Breast Feeding; D002657:Child Development; D016241:Child of Impaired Parents; D015331:Cohort Studies; D005260:Female; D005865:Gestational Age; D006128:Growth / Q000502:physiology*; D015658:HIV Infections; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008413:Mastitis; D010298:Parity; D011247:Pregnancy; D015024:Zambia
chemical_list: D006454:Hemoglobins