title: Back extensor strength and lumbar spinal mobility are predictors of quality of life in patients with postmenopausal osteoporosis.
abstract: To assess the effect of multiple factors on quality of life (QOL) in osteoporosis, relationships between the QOL and possible spinal factors were analyzed in 174 postmenopausal women with osteoporosis. Back extensor strength and lumbar spinal mobility were the most important factors for QOL in these patients.
  
  
  BACKGROUND
  Quality of life (QOL) in patients with osteoporosis and vertebral fractures is impaired by the decline of total spinal mobility, although it is not clear to what extent. This study aimed to assess the effect of multiple factors on QOL in patients with osteoporosis.
  
  
  METHODS
  QOL of 174 postmenopausal women with osteoporosis (mean, 68 years old) was evaluated using the Japanese Osteoporosis QOL Questionnaire (JOQOL). Correlations between the JOQOL score, bone mineral density (BMD) of the lumbar spine/proximal femur/whole body, the kyphosis angle and mobility of thoracic and lumbar spine, the number of vertebral fractures, grip strengths of dominant and non-dominant hands, and isometric back extensor strength (BES) were analyzed.
  
  
  RESULTS
  JOQOL showed significant correlation (p < 0.05) with age (r = -0.303), BES (r = 0.455), dominant and non-dominant grip strengths (r = 0.273 and r = 0.255, respectively), number of vertebral fractures (r = -0.282), BMDs of proximal femur and whole body (r = 0.200 and r = 0.157, respectively), lumbar kyphosis angle (r = -0.296), and lumbar spinal mobility (r = 0.345). Multiple regression analysis revealed that the BES and lumbar spinal mobility were the significant contributors to the JOQOL (p < 0.05).
  
  
  CONCLUSIONS
  BES and lumbar spinal mobility are the important factors for QOL in patients with postmenopausal osteoporosis.
authors: Division of Orthopedic Surgery, Department of Neuro and Locomotor Science, Akita University School of Medicine, 1-1-1 Hondo, Akita 010-8543, Japan. miyakosh@doc.med.akita-u.ac.jp
authors: N
authors: N
authors: Miyakoshi
authors: M
authors: M
authors: Hongo
authors: S
authors: S
authors: Maekawa
authors: Y
authors: Y
authors: Ishikawa
authors: Y
authors: Y
authors: Shimada
authors: E
authors: E
authors: Itoi
mesh_terms: D015502:Absorptiometry, Photon / Q000706:statistics & numerical data; D000368:Aged; D015519:Bone Density / Q000502:physiology*; D005260:Female; D006801:Humans; D007738:Kyphosis / Q000503:physiopathology / Q000523:psychology / Q000628:therapy*; D008159:Lumbar Vertebrae / Q000503:physiopathology*; D008875:Middle Aged; D053580:Muscle Strength / Q000502:physiology*; D015663:Osteoporosis, Postmenopausal / Q000503:physiopathology / Q000523:psychology / Q000628:therapy*; D011237:Predictive Value of Tests; D011788:Quality of Life / Q000523:psychology; D012044:Regression Analysis; D011795:Surveys and Questionnaires