title: [Effect of 2-phenoxyethanol on potency of Sabin inactivated poliomyelitis vaccine and its safety].
abstract: OBJECTIVE
  To investigate the effect of 2-phenoxyethanol on potency of Sabin inactivated poliomyelitis vaccine (IPV).
  
  
  METHODS
  Sabin IPV samples containing 5 mg or 7 mg 2-phenoxyethanol each dosage respectively were placed separately at 4 degrees C, 37 degrees C for 2 days and 7 days. D-antigen contents were tested with ELISA method. Then neutralizing antibodies in mice and guinea pigs were detected. The safety experiment was performed according to unusual toxicity test of China requirement for biological product.
  
  
  RESULTS
  After addition of 2-phenoxyethanol, the I, II, and III D-antigen contents of Sabin IPV did not change. The antibody levels in mice and guinea pigs were not different between experimental group and control group. Animals were safe during observation period.
  
  
  CONCLUSIONS
  2-Phenoxyethanol had no effect on potency and safety of Sabin IPV. It can be used as antiseptic for Sabin IPV.
authors: Institute of Medical Biology, Chinese Academy of Medical Science, Kunming 650118, China.
authors: Chuan-xiu
authors: CX
authors: Bian
authors: Shu-de
authors: SD
authors: Jiang
authors: Jian-yong
authors: JY
authors: Yang
authors: Ming-bo
authors: MB
authors: Sun
authors: Ming-xue
authors: MX
authors: Xie
authors: Xin-wen
authors: XW
authors: Zhang
authors: Guo-yang
authors: GY
authors: Liao
authors: Wei-dong
authors: WD
authors: Li
mesh_terms: D000818:Animals; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage / Q000494:pharmacology / Q000633:toxicity; D000956:Antigens, Viral / Q000032:analysis / Q000276:immunology; D001835:Body Weight / Q000187:drug effects; D002522:Chlorocebus aethiops; D004355:Drug Stability; D004797:Enzyme-Linked Immunosorbent Assay; D005026:Ethylene Glycols / Q000008:administration & dosage / Q000494:pharmacology* / Q000633:toxicity; D006168:Guinea Pigs; D051379:Mice; D009500:Neutralization Tests; D011054:Poliovirus Vaccine, Inactivated / Q000008:administration & dosage / Q000276:immunology* / Q000633:toxicity; D014709:Vero Cells
chemical_list: D000891:Anti-Infective Agents, Local; D000956:Antigens, Viral; D005026:Ethylene Glycols; D011054:Poliovirus Vaccine, Inactivated; C005398:phenoxyethanol