title: Ocular circulation in diabetic patients with coronary artery disease.
abstract: OBJECTIVE
  To evaluate the ocular circulation in diabetic patients with coronary artery disease (CAD).
  
  
  METHODS
  Thirty diabetic patients with diabetic retinopathy of grade 20 or 35, as evaluated by the Early Treatment Diabetic Retinopathy Study, were studied. They were divided into those without CAD (15 cases) and those with CAD (over 75% stenosis of carotid artery; 15 cases). All underwent standard ophthalmic examinations and orbital color Doppler imaging. Fifteen healthy controls underwent the same examinations.
  
  
  RESULTS
  The peak systolic velocity in the central retinal artery was significantly lower in the two diabetic groups. The end-diastolic velocity in the central retinal artery was significantly lower only in the diabetic patients with CAD. There were no significant intergroup differences in blood flow velocities in the ophthalmic artery, short posterior ciliary artery, and central retinal vein. The blood flow waves were flattened in the diastolic phase for all orbital arteries in significantly more eyes in the diabetic patients with CAD. Echocardiography, performed only in the diabetic patients with CAD, showed that 10 cases (67%) had reduced systolic functions and/or diastolic functions and/or asynergy of the left ventricle.
  
  
  CONCLUSIONS
  A decrease in blood flow velocities in the diastolic phase was found in diabetic patients with CAD. The findings indicate that this is probably related to the decrease in cardiac output.
authors: Department of Ophthalmology, Osaka Medical Center for Cancer and Cardiovascular Diseases, 1-3-3 Nakamiti, Higashinari-ku, Osaka 537-8511, Japan. fujioka-sa@mc.pref.osaka.jp
authors: Sayuri
authors: S
authors: Fujioka
authors: Kaoruko
authors: K
authors: Karashima
authors: Norikiyo
authors: N
authors: Nishikawa
authors: Yoshihiro
authors: Y
authors: Saito
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001775:Blood Circulation; D001783:Blood Flow Velocity; D019842:Ciliary Arteries / Q000502:physiology*; D003324:Coronary Artery Disease / Q000503:physiopathology*; D003430:Cross-Sectional Studies; D048909:Diabetes Complications / Q000503:physiopathology*; D003930:Diabetic Retinopathy / Q000503:physiopathology*; D003971:Diastole; D004452:Echocardiography; D005260:Female; D006801:Humans; D017078:Laser-Doppler Flowmetry; D008297:Male; D008875:Middle Aged; D009880:Ophthalmic Artery / Q000502:physiology*; D012039:Regional Blood Flow; D012161:Retinal Artery / Q000502:physiology*