title: Penisporolides A and B, two new spiral lactones from the marine-derived fungus Penicillium sp.
abstract: In our continued screening on bioactive constituents from marine-derived fungi, two novel compounds containing a rare spiral-lactone skeleton were isolated from lyophilized culture broth of the marine-derived fungus Penicillium sp. The structures of penisporolides A and B were elucidated on the basis of extensive 1D and 2D NMR as well as HRESI-MS spectroscopic data analysis. The relative stereochemistries of the compounds were assessed by analysis of NOESY data together with the comparison with data from previous literatures.
authors: State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, PR China. lixi@agr.gc.ca
authors: Xiang
authors: X
authors: Li
authors: Isabel
authors: I
authors: Sattler
authors: Wenhan
authors: W
authors: Lin
mesh_terms: D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010407:Penicillium / Q000737:chemistry* / Q000254:growth & development; D013057:Spectrum Analysis; D013141:Spiro Compounds / Q000737:chemistry / Q000302:isolation & purification*; D013237:Stereoisomerism; D014969:Xanthine Oxidase / Q000037:antagonists & inhibitors
chemical_list: D007783:Lactones; D013141:Spiro Compounds; C520916:penisporolide A; C520917:penisporolide B; D014969:Xanthine Oxidase