High-resolution adaptive optics scanning laser ophthalmoscope with dual deformable mirrors.
Adaptive optics scanning laser ophthalmoscopes have been used to produce noninvasive views of the human retina. However, the range of aberration compensation has been limited by the choice of deformable mirror technology. We demonstrate that the use of dual deformable mirrors can effectively compensate large aberrations in the human eye while maintaining the quality of the retinal imagery. We verified experimentally that the use of dual deformable mirrors improved the dynamic range for correction of the wavefront aberrations compared with the use of the micro-electro-mechanical-system mirror alone and improved the quality of the wavefront correction compared with the use of the bimorph mirror alone. We also demonstrated that the large-stroke bimorph deformable mirror improved the capability for axial sectioning with the confocal imaging system by providing an easier way to move the focus axially through different layers of the retina.
Chen
Diana C
DC
Lawrence Livermore National Laboratory, Livermore, CA 94550, USA. chen47@llnl.gov
Jones
Steven M
SM
Silva
Dennis A
DA
Olivier
Scot S
SS
D004867:Equipment Design; D019544:Equipment Failure Analysis; D006801:Humans; D007089:Image Enhancement / Q000295:instrumentation* / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000295:instrumentation* / Q000379:methods*; D007909:Lenses; D018613:Microscopy, Confocal / Q000295:instrumentation* / Q000379:methods; D019721:Ophthalmoscopes; D019047:Phantoms, Imaging; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity