Microsatellite instability in Bulgarian patients with endometrial cancer.
OBJECTIVE
Microsatellite instability (MSI) is a frequent event in different types of cancer. In several studies MSI was shown to have both clinical and prognostic value. The aim of our study was to determine the frequency of MSI in Bulgarian patients with endometrial cancer (EC) and the possible relation of this phenomenon to their clinicopathological characteristics.


METHODS
A total of 33 histologically confirmed EC patients were analyzed for tumor MSI using a panel of 6 microsatellite markers.


RESULTS
We identified MSI in 30% of endometrial cancer cases. Six of them had high degree of MSI (MSI-H), and 4 displayed low degree of MSI (MSI-L).


CONCLUSIONS
The frequency of MSI in Bulgarian EC patients does not differ significantly from that reported in other European studies.
Konstantinova
D V
DV
Laboratory of Molecular Pathology, University Hospital of Obstetrics and Gynecology Maichin Dom, Sofia, Bulgaria. darivko@gmail.com
Kadiyska
T K
TK
Kaneva
R P
RP
Ivanov
S I
SI
Dimitrov
R G
RG
Dyankova
T V
TV
Meinhardt
K P
KP
Gulubova
M V
MV
Vlaykova
T I
TI
Doganov
N I
NI
Mitev
V I
VI
Kremensky
I M
IM
D000368:Aged; D002031:Bulgaria; D002454:Cell Differentiation; D016889:Endometrial Neoplasms / Q000235:genetics* / Q000473:pathology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D005838:Genotype; D006801:Humans; D053842:Microsatellite Instability; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D010641:Phenotype; D011379:Prognosis; D012189:Retrospective Studies