Design, synthesis and biological evaluation of new oligopyrrole carboxamides linked with tricyclic DNA-intercalators as potential DNA ligands or topoisomerase inhibitors.
In the context of the design and synthesis of minor groove binding and intercalating DNA ligands some new oligopyrrole carboxamides were synthesized. These hybrid molecules (combilexins) possess a variable and conformatively flexible spacer at the N-terminal end. As intercalating tricyclic systems acridone, acridine, anthraquinones and in a special case iminostilbene terminate the N-terminal end of the pyrrole chain. The cytotoxicity was examined by the NCI antitumor screening, furthermore, biophysical as well as biochemical studies were performed in order to get some information about the DNA binding properties and topoisomerase inhibition effect of this new series of molecules.
David-Cordonnier
Marie-Hélène
MH
INSERM U837-JPARC, Equipe N degrees 4, Institut de Recherches sur le Cancer de Lille, Place de Verdun, 59045 Lille Cedex, France.
Hildebrand
Marie-Paule
MP
Baldeyrou
Brigitte
B
Lansiaux
Amelie
A
Keuser
Christoph
C
Benzschawel
Kerstin
K
Lemster
Thomas
T
Pindur
Ulf
U
D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D004247:DNA / Q000737:chemistry / Q000378:metabolism*; D018983:DNA Footprinting; D004214:Distamycins / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D015195:Drug Design; D006801:Humans; D007364:Intercalating Agents / Q000737:chemistry*; D008024:Ligands; D015394:Molecular Structure; D009429:Netropsin / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D011758:Pyrroles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship; D059003:Topoisomerase Inhibitors
D000970:Antineoplastic Agents; D004214:Distamycins; D007364:Intercalating Agents; D008024:Ligands; D011758:Pyrroles; D059003:Topoisomerase Inhibitors; D009429:Netropsin; C030000:stallimycin; D004247:DNA