Preparation of microcapsules with self-microemulsifying core by a vibrating nozzle method.
Incorporation of drugs in self-microemulsifying systems (SMES) offers several advantages for their delivery, the main one being faster drug dissolution and absorption. Formulation of SMES in solid dosage forms can be difficult and, to date, most SMES are applied in liquid dosage form or soft gelatin capsules. This study has explored the incorporation of SMES in microcapsules, which could then be used for formulation of solid dosage forms. An Inotech IE-50 R encapsulator equipped with a concentric nozzle was used to produce alginate microcapsules with a self-microemulsifying core. Retention of the core phase was improved by optimization of encapsulator parameters and modification of the shell forming phase and hardening solution. The mean encapsulation efficiency of final batches was more than 87%, which resulted in 0.07% drug loading. It was demonstrated that production of microcapsules with a self-microemulsifying core is possible and that the process is stable and reproducible.
Homar
Miha
M
Lek Pharmaceuticals d.d., Research and development, Ljubljana, Slovenia.
Suligoj
Dasa
D
Gasperlin
Mirjana
M
D002214:Capsules / Q000302:isolation & purification*; D004339:Drug Compounding / Q000379:methods*; D016503:Drug Delivery Systems; D004655:Emulsions; D007660:Ketoprofen / Q000008:administration & dosage; D010316:Particle Size; D014732:Vibration
D002214:Capsules; D004655:Emulsions; D007660:Ketoprofen