title: Elliptical nonmechanical corneal trephination: intraoperative complications and long-term outcome of 42 consecutive excimer laser penetrating keratoplasties.
abstract: OBJECTIVE
  To assess intraoperative complications and long-term outcome of elliptical excimer laser trephination for penetrating keratoplasties (EELPKs) performed at the Friedrich-Alexander University of Erlangen, between 1989 and 2002.
  
  
  METHODS
  This was a retrospective, longitudinal, single-center, clinical, interventional case series. Forty-two eyes (14 Fuchs dystrophy, 11 corneal ulcer, 7 aphakic/pseudophakic bullous keratopathy, 9 corneal scars, 1 keratotorus) after EELPK were observed. Trephination was performed with a 193-nm Meditec excimer laser along metal masks with 0-8 orientation teeth/notches. Horizontal/vertical graft diameters ranged from 7.0/6.0 to 8.0/7.0 mm, and 12 to 24 interrupted sutures were used. Simultaneously, 11 eyes (26.2%) underwent cataract surgery, 3 (7.1%) underwent intraocular lens (IOL) exchange, and 1 (2.4%) underwent secondary IOL implantation. The main outcome measures included intraoperative complications, immune reactions, and final astigmatism/visual acuity at the end of follow-up.
  
  
  RESULTS
  During surgery, 4 (9.5%) recipients had iris bleedings, and 10 (23.8%) ring-shaped superficial corneal thermal donor damages were detected. One (2.4%) immunologic graft rejection was seen in Fuchs dystrophy, and 3 (7.1%) in corneal ulcers occurred during follow-up (4.7 +/- 3.2 years). At the end of follow-up, corrected visual acuity (0.1/0.4; P < 0.001) and keratometric astigmatism (2.3 D/4.7 D, P = 0.001) increased significantly.
  
  
  CONCLUSIONS
  In EELPK, intraoperative disadvantages, such as the need for interrupted sutures and a tendency toward higher and more irregular astigmatism, may be expected. This study does not have the power to statistically confirm the tendency of EELPK toward a lower rate of immunologic graft rejections after normal-risk keratoplasty. However, EELPK may have advantages in deep or perforated elliptically shaped corneal ulcers (such as in acanthamoeba keratitis).
authors: Department of Ophthalmology, Friedrich Alexander University of Erlangen-Nürnberg, Erlangen, Germany. nszentmary@hotmail.com
authors: Nóra
authors: N
authors: Szentmáry
authors: Achim
authors: A
authors: Langenbucher
authors: Murat M
authors: MM
authors: Kus
authors: Gottfried O H
authors: GO
authors: Naumann
authors: Berthold
authors: B
authors: Seitz
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003316:Corneal Diseases / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007431:Intraoperative Complications; D015948:Keratoplasty, Penetrating / Q000295:instrumentation / Q000379:methods*; D053685:Laser Therapy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013536:Suture Techniques; D014019:Tissue Donors; D016896:Treatment Outcome