Increased prothrombin time and lactic acidosis: rofecoxib drug interaction with acenocoumarin and metformin.
Tewari
Prabhat
P
Department of Anaesthesiology and Cardiothoracic and Vascular Surgery, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow. ptewari123@yahoo.co.in
Nath
Soumya Sankar
SS
Mazumdar
Gauranga
G
D000074:Acenocoumarol / Q000009:adverse effects*; D000140:Acidosis, Lactic / Q000097:blood / Q000139:chemically induced*; D000925:Anticoagulants / Q000009:adverse effects; D001024:Aortic Valve Stenosis / Q000601:surgery; D052246:Cyclooxygenase 2 Inhibitors / Q000009:adverse effects; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy; D004347:Drug Interactions; D005260:Female; D019918:Heart Valve Prosthesis Implantation; D006801:Humans; D007004:Hypoglycemic Agents / Q000009:adverse effects; D007783:Lactones / Q000009:adverse effects*; D008687:Metformin / Q000009:adverse effects*; D008875:Middle Aged; D011517:Prothrombin Time; D013450:Sulfones / Q000009:adverse effects*
D000925:Anticoagulants; D052246:Cyclooxygenase 2 Inhibitors; D007004:Hypoglycemic Agents; D007783:Lactones; D013450:Sulfones; C116926:rofecoxib; D008687:Metformin; D000074:Acenocoumarol