Curcumin prevents the development of dextran sulfate Sodium (DSS)-induced experimental colitis.
Curcumin is a phenolic natural product isolated from the rhizome of Curcuma longa (turmeric). We evaluated the effects of curcumin on the development of dextran sulfate sodium (DSS)-induced experimental colitis. BALB/c mice were fed a chow containing either 3.5% (wt/wt) DSS or 3.5% DSS + 2.0% (wt/wt) curcumin. The body weight loss was more apparent in DSS-treated mice than in DSS + curcumin-treated mice. The disease activity index, histological colitis score, and MPO activity were all significantly higher in DSS-treated mice than in DSS plus curcumin-treated mice. Microscopically, mucosal edema, cellular infiltration, and epithelial disruption were much more severe in DSS-treated mice than in DSS + curcumin-treated mice. In DSS + curcumin-treated mice, NF-kappaB activation was blocked in the mucosa. In conclusion, the development of DSS-induced colitis was significantly attenuated by curcumin. Being a nontoxic natural dietary product, curcumin could be useful in treatment of IBD patients.
Deguchi
Yasuyuki
Y
Department of Internal Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu, 520-2192, Japan.
Andoh
Akira
A
Inatomi
Osamu
O
Yagi
Yuhki
Y
Bamba
Shigeki
S
Araki
Yoshio
Y
Hata
Kazunori
K
Tsujikawa
Tomoyuki
T
Fujiyama
Yoshihide
Y
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D003092:Colitis / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D003106:Colon / Q000187:drug effects / Q000201:enzymology / Q000473:pathology; D003474:Curcumin / Q000627:therapeutic use*; D016264:Dextran Sulfate / Q000633:toxicity*; D004195:Disease Models, Animal; D007150:Immunohistochemistry; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009195:Peroxidase / Q000378:metabolism; D010952:Plasma Substitutes / Q000633:toxicity
D000970:Antineoplastic Agents; D010952:Plasma Substitutes; D016264:Dextran Sulfate; D009195:Peroxidase; D003474:Curcumin