title: [Comparative study on transdermal osmosis in vitro of Aconitum brachypodium liniment, gel and patcher].
abstract: OBJECTIVE
  To study the transdermal osmosis process of Aconitum brachypodum's liniment, gel and patcher to provide basis for selecting dosage form and controlling the quality.
  
  
  METHODS
  Taking the cumulate rate of transdermal as index, a imitated Fick's diffusion device was used for the investigating the transdermal osmosis course of the three preparations. The best transdermal mathematics models are obtained and the relations between the transdermal course and the release course are analysed.
  
  
  RESULTS
  The three preparations have different characteristics of transdermal osmosis course. The liniment meets dynamics 0 order process, the gel and the patcher meet dynamic 0 order process of non-corroded drug system. And the relation is good cubic equation between their transdermal course and release course.
  
  
  CONCLUSIONS
  The transdermal osmosis experiment in vitro for three preparations can provide basis for selecting dosage form and the quality control in future studies.
authors: Guizhou Province Drug Administration, Guiyang 550004, China lypgz@126.com
authors: Ya-ping
authors: YP
authors: Lin
authors: Ying
authors: Y
authors: Zhao
authors: Yong-ping
authors: YP
authors: Zhang
authors: Guang-yi
authors: GY
authors: Liang
mesh_terms: D031841:Aconitum / Q000737:chemistry*; D000279:Administration, Cutaneous; D000818:Animals; D004058:Diffusion; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000302:isolation & purification / Q000493:pharmacokinetics*; D066298:In Vitro Techniques; D008297:Male; D009995:Osmosis; D035281:Plant Tubers / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D011817:Rabbits; D012867:Skin / Q000378:metabolism*; D012869:Skin Absorption
chemical_list: D004365:Drugs, Chinese Herbal