title: PKC defends crown against Munc13.
abstract: Protein kinase C has long been thought to mediate DAG signaling at the synapse. Recently PKC has been supplanted by members of the Unc13 family as the predominant effectors of DAG signaling. Thanks to a study by Wierda and colleagues in this issue of Neuron, PKC returns to reclaim part of the kingdom: both pathways must be active to activate presynaptic potentiation.
authors: Department of Biology and Howard Hughes Medical Institute, University of Utah, 257 South 1400 East, Salt Lake City, UT 84112-0840, USA.
authors: Mark
authors: M
authors: Palfreyman
authors: Erik M
authors: EM
authors: Jorgensen
mesh_terms: D004075:Diglycerides / Q000502:physiology*; D006801:Humans; D009419:Nerve Tissue Proteins / Q000502:physiology*; D010703:Phorbol Esters / Q000494:pharmacology; D010766:Phosphorylation; D011493:Protein Kinase C / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology; D009435:Synaptic Transmission / Q000187:drug effects / Q000502:physiology
chemical_list: D004075:Diglycerides; D009419:Nerve Tissue Proteins; D010703:Phorbol Esters; C485548:UNC13B protein, human; D011493:Protein Kinase C