title: Genetically determined mannan-binding lectin deficiency is of minor importance in determining susceptibility to severe infections and vascular organ damage in systemic lupus erythematosus.
abstract: Deficiency of mannan-binding lectin (MBL) has been reported to impact susceptibility to severe infections and atherosclerosis in systemic lupus erythematosus (SLE). In this study, MBL gene polymorphisms were analysed in 143 SLE patients and the frequency of severe infections and organ damage according to SLICC/ACR Damage Index regarding cerebrovascular accidents, angina pectoris, coronary by-pass surgery, myocardial infarction and peripheral arterial disease leading to significant tissue loss, were recorded during a mean follow-up time of 15 years from diagnosis. In a multiple logistic regression model, smoking (P = 0.001), hypertension (P = 0.030), alcohol intake (P = 0.027) and higher triglyceride concentration (P = 0.026) were associated with cerebrovascular, cardiovascular and peripheral arterial organ damage (CPAD), while the association with MBL deficiency did not reach significance (P = 0.098). Alcohol intake (>15 g/month) was inversely correlated with CPAD (OR = 0.29, 95%CI 0.096-0.87). MBL deficiency was not significantly more common in SLE patients with severe infections in a multivariate analysis (P > 0.3). In conclusion, classical risk factors such as smoking, hypertension, low alcohol intake and elevated triglyceride concentration were relatively more important for development of CPAD than MBL deficiency in SLE. Furthermore, MBL deficiency did not contribute to development of major infections in SLE.
authors: Department of Clinical Sciences, Section of Rheumatology, Lund University, Lund, Sweden. Jonsen@med.lu.se
authors: A
authors: A
authors: Jönsen
authors: B
authors: B
authors: Gullstrand
authors: N
authors: N
authors: Güner
authors: A A
authors: AA
authors: Bengtsson
authors: O
authors: O
authors: Nived
authors: L
authors: L
authors: Truedsson
authors: G
authors: G
authors: Sturfelt
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000428:Alcohol Drinking; D001424:Bacterial Infections / Q000150:complications / Q000276:immunology*; D004198:Disease Susceptibility / Q000276:immunology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000235:genetics / Q000276:immunology* / Q000382:microbiology; D008297:Male; D037601:Mannose-Binding Lectin / Q000172:deficiency* / Q000235:genetics; D008875:Middle Aged; D016491:Peripheral Vascular Diseases / Q000150:complications*; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects
chemical_list: D037601:Mannose-Binding Lectin