title: [Cost-effectiveness analysis of maximum androgen blockade for Japanese men with advanced prostate cancer].
abstract: Like other countries, Japan is facing the problem of rising medical costs associated with aging of the population, and therefore the cost-effectiveness of medicines has become increasingly important. Maximum androgen blockade (MAB) therapy, which is being widely used for advanced prostate cancer, has proved useful in clinical studies but it requires the additional use of an anti-androgen in contrast with luteinizing hormone releasing hormone agonist (LHRHa) monotherapy, raising a concern about the increase medical costs. Thus, based on the results of a Japanese Phase III study of bicalutamide we performed a cost-effectiveness analysis. We constructed a Markov model to express the changes in prognosis following MAB therapy and LHRHa monotherapy for advanced prostate cancer and the cost and effectiveness (survival) were simulated. As a result, the expected costs of MAB therapy and LHRHa monotherapy were 5,240,000 yen and 3,660,000 yen, respectively, with expected survival durations of 7.45 and 6.44 years. The incremental cost-effectiveness ratio for MAB therapy was 1,560,000 yen/life-year saved, lower than the established threshold (6,000,000 yen/life-year saved), and a sensitivity analysis confirmed the robustness of this result. Therefore, the incremental cost of bicalutamide was considered worth it in view of the therapeutic effect, suggesting that MAB therapy is a highly cost-effective therapy.
authors: Kyoto University, Graduate School of Economics.
authors: Shuzo
authors: S
authors: Nishimura
authors: Yoichi
authors: Y
authors: Arai
authors: Michiyuki
authors: M
authors: Usami
authors: Hiroshi
authors: H
authors: Kanetake
authors: Seiji
authors: S
authors: Naito
authors: Hideyuki
authors: H
authors: Akaza
mesh_terms: D000368:Aged; D000726:Androgen Antagonists / Q000191:economics* / Q000627:therapeutic use*; D003362:Cost-Benefit Analysis; D004334:Drug Administration Schedule; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists; D006801:Humans; D008297:Male; D008390:Markov Chains; D017059:Models, Econometric; D009010:Monte Carlo Method; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000191:economics* / Q000401:mortality; D015996:Survival Rate
chemical_list: D000726:Androgen Antagonists; D007987:Gonadotropin-Releasing Hormone