Corpus callosotomy using conformal stereotactic radiosurgery.
OBJECTIVE
To show the clinical results of a corpus callosotomy (CC) treatment using conformal stereotactic radiosurgery (SRS) on a patient with medically intractable multifocal epilepsy.


METHODS
A 17-year-old male patient underwent corpus callosotomy conformal SRS using a dedicated linear accelerator (linac) with dynamic arcs technique. The prescribed dose was 36.0 Gy at the periphery of the rostrum, genu, and a half of the body of the corpus callosum (CCA). At 8 months after conformal SRS, the patient developed a significant brain edema and moderate transitory motor deficit, which were controlled with steroids. After 32 months follow-up, there is an improvement of 84% on drop attacks and generalized tonic-clonic seizures.


CONCLUSIONS
Conformal SRS for corpus callosotomy with a single isocenter reproduce the results reported on literature using Gamma Knife-based SRS. The results show that this technique is safe and demonstrate its efficacy to control seizures.
Celis
M A
MA
Unidad de Radioneurocirugía, Instituto Nacional de Neurología y Neurocirugía, Insurgentes sur 3877, La Fama, Tlalpan, 14269, México, D.F., México. macelisl@yahoo.com.mx
Moreno-Jiménez
S
S
Lárraga-Gutiérrez
J M
JM
Alonso-Vanegas
M A
MA
García-Garduño
O A
OA
Martínez-Juárez
I E
IE
Fernández-Gónzalez
M C
MC
D000293:Adolescent; D000927:Anticonvulsants / Q000627:therapeutic use; D001929:Brain Edema / Q000209:etiology / Q000473:pathology / Q000628:therapy; D003337:Corpus Callosum / Q000473:pathology / Q000601:surgery*; D004351:Drug Resistance; D004569:Electroencephalography; D004827:Epilepsy / Q000601:surgery; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D010291:Paresis / Q000209:etiology; D010315:Particle Accelerators; D011183:Postoperative Complications / Q000473:pathology / Q000628:therapy; D016634:Radiosurgery; D020266:Radiotherapy, Conformal; D014057:Tomography, X-Ray Computed
D000927:Anticonvulsants