title: New onset heightened interest or drive for gambling, shopping, eating or sexual activity in patients with Parkinson's disease: the role of dopamine agonist treatment and age at motor symptoms onset.
abstract: Alterations of impulse control that have recently been associated with Parkinson's disease (PD) are serious behavioural disturbances with significant impact on PD patients and their families.A total of 193 consecutive PD patients with no history of psychiatric illness and 190 age/gender-matched healthy controls were queried on the presence of new onset heightened interest or drive for gambling, shopping, eating or sexual activity (GSES). Clinical data were retrieved from medical charts and interviews. logistic regressions models assessed risk factors for these specific troublesome behaviours. New or heightened interests or drives for GSES behaviours were reported by 27 patients (14% vs 0% for controls). Younger age at PD motor symptoms onset (OR = 0.99, p = 0.0172), male gender (OR = 1.10, p = 0.0576) and longer duration of treatment with dopamine agonists (DAs)(OR = 1.18, >/=6 years versus never treated, p = 0.0459) contributed additively to the risk of developing one or more of these behavioural features. New onset heightened interests or drives for GSES are not rare behavioural disturbances among patients with PD. Age, gender and duration of treatment with DAs have an independent and additive effect on the risk to develop such behavioural changes. Patients should be informed about potential treatment-associated behavioural changes.
authors: Movement Disorders Unit and Parkinson Centre, Department of Neurology, Tel-Aviv Sourasky Medical Centre, Tel-Aviv, Israel. nirg@tasmc.health.gov.il
authors: Nir
authors: N
authors: Giladi
authors: Nina
authors: N
authors: Weitzman
authors: Shaul
authors: S
authors: Schreiber
authors: Herzel
authors: H
authors: Shabtai
authors: Chava
authors: C
authors: Peretz
mesh_terms: D000328:Adult; D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D000978:Antiparkinson Agents / Q000009:adverse effects*; D016022:Case-Control Studies; D018491:Dopamine Agonists / Q000009:adverse effects*; D005247:Feeding Behavior / Q000187:drug effects*; D005260:Female; D005715:Gambling; D006801:Humans; D007175:Impulsive Behavior / Q000209:etiology*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010300:Parkinson Disease / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology / Q000523:psychology*; D018570:Risk Assessment; D012307:Risk Factors; D012737:Sex Factors; D012725:Sexual Behavior / Q000187:drug effects*; D014202:Tremor / Q000453:epidemiology / Q000209:etiology*
chemical_list: D000978:Antiparkinson Agents; D018491:Dopamine Agonists