Platelets: the universal killer?
For many, the final terminal event in life is cessation of the heart beat. In turn, this is generally because this organ has been deprived of oxygen and glucose as the blood can no longer deliver these requirements to the myocardium. The principal reason for this is blockage of one or more coronary arteries or arterioles by platelet rich thrombus. A similar process exists for the pathophysiology of stroke--a disabilitating and often fatal event caused by occlusion or rupture of arteries in, or feeding, the brain. These scenarios are best developed in cardiovascular disease, but apply to almost all human disease. Therefore, the ultimate culprit for these major life events is the overactive platelet-too ready to form an inappropriate thrombus. Thus, one way forward in postponing an occlusive thrombotic event is to minimise platelet activation, new tools and treatments for which are eagerly sought.
Blann
Andrew D
AD
Haemostasis, Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, B18 7QH, UK. a.blann@bham.ac.uk
D001792:Blood Platelets / Q000502:physiology*; D006801:Humans; D020521:Stroke / Q000503:physiopathology*; D013927:Thrombosis / Q000503:physiopathology*