title: Prion protein alleles showing a protective effect on the susceptibility of sheep to scrapie and bovine spongiform encephalopathy.
abstract: The susceptibility of sheep to classical scrapie and bovine spongiform encephalopathy (BSE) is mainly influenced by prion protein (PrP) polymorphisms A136V, R154H, and Q171R, with the ARR allele associated with significantly decreased susceptibility. Here we report the protective effect of the amino acid substitution M137T, I142K, or N176K on the ARQ allele in sheep experimentally challenged with either scrapie or BSE. Such observations suggest the existence of additional PrP alleles that significantly decrease the susceptibility of sheep to transmissible spongiform encephalopathies, which may have important implications for disease eradication strategies.
authors: Istituto Superiore di Sanità, Department of Food Safety and Veterinary Public Health, Viale Regina Elena 299, 00161 Rome, Italy. gabriele.vaccari@iss.it
authors: Gabriele
authors: G
authors: Vaccari
authors: Claudia
authors: C
authors: D'Agostino
authors: Romolo
authors: R
authors: Nonno
authors: Francesca
authors: F
authors: Rosone
authors: Michela
authors: M
authors: Conte
authors: Michele Angelo
authors: MA
authors: Di Bari
authors: Barbara
authors: B
authors: Chiappini
authors: Elena
authors: E
authors: Esposito
authors: Luigi
authors: L
authors: De Grossi
authors: Francesco
authors: F
authors: Giordani
authors: Stefano
authors: S
authors: Marcon
authors: Luisella
authors: L
authors: Morelli
authors: Renata
authors: R
authors: Borroni
authors: Umberto
authors: U
authors: Agrimi
mesh_terms: D000483:Alleles; D019943:Amino Acid Substitution; D000818:Animals; D001483:Base Sequence; D002417:Cattle; D016643:Encephalopathy, Bovine Spongiform / Q000235:genetics* / Q000635:transmission; D020022:Genetic Predisposition to Disease; D008969:Molecular Sequence Data; D020641:Polymorphism, Single Nucleotide; D011328:Prions / Q000235:genetics* / Q000472:pathogenicity; D012608:Scrapie / Q000235:genetics* / Q000635:transmission; D012756:Sheep
chemical_list: D011328:Prions