title: Patterning skin pigmentation via dickkopf.
abstract: One of the striking regional variations in skin is its pigmentation. Yamaguchi et al. further dissect the mechanism of regional pigmentation by assessing the effects of dickkopf 1 (DKK1), an antagonist of the Wnt pathway produced in lightly pigmented skin, on melanocyte gene expression. The results provide a plethora of candidate genes that may mediate DKK1's inhibitory effects on melanocyte function.
authors: Program in Epithelial Biology, Stanford University, Stanford, California 94305, USA. howchang@stanford.edu
authors: Howard Y
authors: HY
authors: Chang
mesh_terms: D005347:Fibroblasts / Q000502:physiology; D005786:Gene Expression Regulation; D038362:Glycogen Synthase Kinase 3 / Q000235:genetics / Q000502:physiology; D000071679:Glycogen Synthase Kinase 3 beta; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics / Q000502:physiology*; D008544:Melanocytes / Q000502:physiology; D012880:Skin Pigmentation / Q000502:physiology*; D051153:Wnt Proteins / Q000037:antagonists & inhibitors; D051176:beta Catenin / Q000235:genetics / Q000502:physiology
chemical_list: C501126:DKK1 protein, human; D036341:Intercellular Signaling Peptides and Proteins; D051153:Wnt Proteins; D051176:beta Catenin; D000071679:Glycogen Synthase Kinase 3 beta; D038362:Glycogen Synthase Kinase 3