title: Replication-competent HIV strains infect HIV controllers despite undetectable viremia (ANRS EP36 study).
abstract: The replicative potential of HIV-1 strains in a well-characterized group of eight HIV controllers was investigated. Replication-competent viruses were detected in CD4 T-cell co-culture supernatants from all HIV controllers. The phylogenetic analysis of C2V4 suggested viral evolution or co-infection or superinfection in two out of the four patients analysed. The vif and vpr genes were normal. Infection with HIV-1 variants with attenuated replicative capacity cannot be a general factor accounting for undetectable viraemia in HIV controllers.
authors: INSERM U802, Paris XI University, Bicêtre, France.
authors: Aurelia
authors: A
authors: Lamine
authors: Anne
authors: A
authors: Caumont-Sarcos
authors: Marie-Laure
authors: ML
authors: Chaix
authors: Asier
authors: A
authors: Saez-Cirion
authors: Christine
authors: C
authors: Rouzioux
authors: Jean-François
authors: JF
authors: Delfraissy
authors: Gianfranco
authors: G
authors: Pancino
authors: Olivier
authors: O
authors: Lambotte
mesh_terms: D015496:CD4-Positive T-Lymphocytes / Q000821:virology; D002478:Cells, Cultured; D015686:Gene Products, env / Q000235:genetics; D015658:HIV Infections / Q000276:immunology / Q000821:virology*; D015497:HIV-1 / Q000235:genetics / Q000472:pathogenicity / Q000502:physiology*; D006801:Humans; D010802:Phylogeny; D014766:Viremia / Q000821:virology; D014779:Virus Replication
chemical_list: D015686:Gene Products, env