Prophylactic effect of dietary seaweed Fucoidan against enteral prion infection.
Dietary seaweed fucoidan delays the onset of disease of enterally infected mice with scrapie when given orally for 6 days after infection, but not when given before the infection. This effect was not modified at a tested fucoidan dose range and appeared to reach the maximum level at a concentration of 2.5% or less in feed. Daily uptake of fucoidan might be prophylactic against prion diseases caused by ingestion of prion-contaminated materials, although further evaluation of its pharmacology remains to be done.
Doh-Ura
Katsumi
K
Department of Prion Research, Tohoku University Graduate School of Medicine, 2-1 Seiryo-cho, Aoba-ku, Sendai, Miyagi 980-8575, Japan. doh-ura@mail.tains.tohoku.ac.jp
Kuge
Tomoko
T
Uomoto
Miyuki
M
Nishizawa
Keiko
K
Kawasaki
Yuri
Y
Iha
Masahiko
M
D000284:Administration, Oral; D000818:Animals; D002417:Cattle; D045744:Cell Line, Tumor; D004032:Diet; D005643:Fucose; D006801:Humans; D008517:Phytotherapy; D011134:Polysaccharides / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D018620:PrPSc Proteins / Q000008:administration & dosage* / Q000472:pathogenicity; D017096:Prion Diseases / Q000517:prevention & control*; D011328:Prions; D012608:Scrapie / Q000517:prevention & control; D012624:Seaweed / Q000737:chemistry*
D011134:Polysaccharides; D018620:PrPSc Proteins; D011328:Prions; D005643:Fucose; C007789:fucoidan