title: Antimicrobial and cytotoxic activity of agelasine and agelasimine analogs.
abstract: Agelasine and agelasimine derivatives with substantially less complicated terpenoid side chains compared to the naturally occurring compounds have been synthesized and their ability to inhibit growth of microorganisms and cancer cells has been studied. Compounds with excellent activity against cancer cell lines (MIC ca. 1 microM for the most potent compounds), including a drug resistant renal cell line, have been identified. Most compounds studied also exhibited broad spectrum antimicrobial activity including activity against Mycobacterium tuberculosis.
authors: Department of Chemistry, University of Oslo, Blindern, N-0315 Oslo, Norway.
authors: Anders
authors: A
authors: Vik
authors: Erik
authors: E
authors: Hedner
authors: Colin
authors: C
authors: Charnock
authors: Linda W
authors: LW
authors: Tangen
authors: Ørjan
authors: Ø
authors: Samuelsen
authors: Rolf
authors: R
authors: Larsson
authors: Lars
authors: L
authors: Bohlin
authors: Lise-Lotte
authors: LL
authors: Gundersen
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents