Total synthesis of anibamine, a novel natural product as a chemokine receptor CCR5 antagonist.
The total synthesis of anibamine, the first and only natural product known as a chemokine receptor CCR5 antagonist, is reported herein. Anibamine was synthesized from acetylacetone and cyanoacetamide in 10 steps.
Li
Guo
G
Department of Medicinal Chemistry, Virginia Commonwealth University, Richmond, VA 23298-0540, USA.
Watson
Karen
K
Buckheit
Robert W
RW
Zhang
Yan
Y
D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D065100:CCR5 Receptor Antagonists; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D007536:Isomerism; D015394:Molecular Structure; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
D001688:Biological Products; D065100:CCR5 Receptor Antagonists; D011725:Pyridines; C488244:anibamine