All-dry synthesis and coating of methacrylic acid copolymers for controlled release.
Initiated chemical vapor deposition (iCVD) is presented as an all-dry synthesis and coating method for applying methacrylic acid copolymers as pH-responsive controlled release layers. iCVD combines the strengths of liquid-phase chemical synthesis with a precision solvent-free chemical vapor deposition environment. Copolymers of methacrylic acid and ethyl acrylate were confirmed by a systematic shift in the carbonyl bond stretching mode with a shift in the comonomer ratio within the copolymer and by the ability to apply the Fineman-Ross copolymerization equation to describe copolymerization kinetics. Copolymers of methacrylic acid and ethylene dimethacrylate showed pH-dependent swelling behavior that was applied to the enteric release of fluorescein and ibuprofen.
Lau
Kenneth K S
KK
Department of Chemical and Biological Engineering, Drexel University, 3141 Chestnut Street, Philadelphia, Pennsylvania 19104, USA. klau@drexel.edu
Gleason
Karen K
KK
D000179:Acrylates / Q000737:chemistry*; D018712:Analgesics, Non-Narcotic / Q000737:chemistry; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000138:chemical synthesis* / Q000737:chemistry; D019793:Fluorescein / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D007052:Ibuprofen / Q000737:chemistry; D008689:Methacrylates / Q000737:chemistry*; D011109:Polymethacrylic Acids / Q000138:chemical synthesis* / Q000737:chemistry; D014835:Volatilization
D000179:Acrylates; D018712:Analgesics, Non-Narcotic; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D008689:Methacrylates; D011109:Polymethacrylic Acids; C008384:methacrylic acid; C040833:ethyl acrylate; D019793:Fluorescein; D007052:Ibuprofen