[Melatonin against surgical stress].
Surgery is associated with oxidative stress. Oxidative stress is correlated with postoperative myocardial ischaemia. It has been shown that the endogenous hormone melatonin has antioxidant effects. A potential benefit of melatonin has been proven in experimental studies as well as in neonates. Melatonin has not been used in adult patients with acute oxidative stress. A potential beneficial effect of melatonin in patients after surgery is possible and should be investigated in the future.
Kücükakin
Bülent
B
Gentofte Hospital, Kirurgisk Gastroenterologisk Afdeling D. bulkuc01@gentoftehosp.kbhamt.dk
Gögenur
Ismail
I
Rosenberg
Jacob
J
D000328:Adult; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage*; D006801:Humans; D007231:Infant, Newborn; D008550:Melatonin / Q000008:administration & dosage*; D017202:Myocardial Ischemia / Q000209:etiology / Q000517:prevention & control; D018384:Oxidative Stress / Q000187:drug effects*; D011183:Postoperative Complications / Q000209:etiology / Q000517:prevention & control; D018805:Sepsis / Q000209:etiology / Q000517:prevention & control; D013514:Surgical Procedures, Operative / Q000009:adverse effects*
D000975:Antioxidants; D008550:Melatonin