Synthesis of oxiran-2-ylmethyl and oxiran-2-ylmethoxy derivatives of some 4-azatricyclo[5.2.1.0(2,6)]dec-8-ene-3,5-diones as potential beta-adrenolytics.
A series of aminoalkanol derivatives of 10-(diphenylmethylene)-4-azatricyclo[5.2.1.0(2.6)]dec-8-ene-3,5-dione and 4-hydroxy-4-azatricyclo[5.2.1.0(2,6)]dec-8-ene-3,5-dione have been prepared. The pharmacological profile of selected compounds was evaluated for their affinities at beta-adrenoceptors. The investigated compounds exhibit modest affinity for these receptors.
Kossakowski
Jerzy
J
Department of Medical Chemistry, The Medical University of Warsaw, 3 Oczki Street, 02-007 Warsaw, Poland. jerzykos@amwaw.edu.pl
Wojciechowska
Anna
A
D000319:Adrenergic beta-Antagonists / Q000138:chemical synthesis* / Q000378:metabolism; D000818:Animals; D015195:Drug Design; D005027:Ethylene Oxide / Q000138:chemical synthesis; D006572:Heterocyclic Compounds, Bridged-Ring / Q000138:chemical synthesis*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D011943:Receptors, Adrenergic, beta / Q000378:metabolism
D000319:Adrenergic beta-Antagonists; D006572:Heterocyclic Compounds, Bridged-Ring; D011943:Receptors, Adrenergic, beta; D005027:Ethylene Oxide