title: [Serum bone markers in patients with loosening of cemented total hip endoprosthesis].
abstract: Serum levels of bone markers N-mid osteocalcin (OCN-Mid) and Cross-Laps in 20 patients (8 men and 12 women) with loosening of at least one element of total hip endoprosthesis confirmed during operation were compared with age and sex matched group with OA. Marker levels were measured by direct chemoluminescency using Modular E-170. Statistical analysis were done with t-Student test (alpha = 0.05). There were no significant differences in OCN-Mid, Cross-Laps levels and OCN-Mid/Cross-Laps ratio between both groups. Implant loosening is a slow process taking place on a relatively small surface in comparison to whole skeleton, so bone markers have no clinical value in diagnostics of total hip loosening.
authors: Oddział Ortopedyczno-Urazowy Wojewódzkiego Szpitala Specjalistycznego im. M. Kopernika w Lodzi.
authors: Michał
authors: M
authors: Panasiuk
authors: Marek
authors: M
authors: Synder
authors: Maryla
authors: M
authors: Drynkowska-Panasiuk
authors: Oktawiusz
authors: O
authors: Bończak
mesh_terms: D000368:Aged; D019644:Arthroplasty, Replacement, Hip; D015415:Biomarkers / Q000097:blood*; D003094:Collagen / Q000097:blood*; D005260:Female; D006622:Hip Prosthesis; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D015207:Osteoarthritis, Hip / Q000097:blood* / Q000628:therapy*; D015675:Osteocalcin / Q000097:blood; D010446:Peptide Fragments / Q000097:blood*; D011475:Prosthesis Failure; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D015415:Biomarkers; D010446:Peptide Fragments; C110762:glutamyl-lysyl-alanyl-histidyl-aspartyl-glycyl-glycyl-arginine; D015675:Osteocalcin; D003094:Collagen