Optimizing the laser-pulse configuration for coherent Raman spectroscopy.
We introduce a hybrid technique that combines the robustness of frequency-resolved coherent anti-Stokes Raman scattering (CARS) with the advantages of time-resolved CARS spectroscopy. Instantaneous coherent broadband excitation of several characteristic molecular vibrations and the subsequent probing of these vibrations by an optimally shaped time-delayed narrowband laser pulse help to suppress the nonresonant background and to retrieve the species-specific signal. We used this technique for coherent Raman spectroscopy of sodium dipicolinate powder, which is similar to calcium dipicolinate (a marker molecule for bacterial endospores, such as Bacillus subtilis and Bacillus anthracis), and we demonstrated a rapid and highly specific detection scheme that works even in the presence of multiple scattering.
Pestov
Dmitry
D
Institute for Quantum Studies and Departments of Physics and Chemical Engineering, Texas A&M University, College Station, TX 77843, USA. dmip@neo.tamu.edu
Murawski
Robert K
RK
Ariunbold
Gombojav O
GO
Wang
Xi
X
Zhi
Miaochan
M
Sokolov
Alexei V
AV
Sautenkov
Vladimir A
VA
Rostovtsev
Yuri V
YV
Dogariu
Arthur
A
Huang
Yu
Y
Scully
Marlan O
MO
D001412:Bacillus subtilis / Q000302:isolation & purification; D007834:Lasers; D010848:Picolinic Acids / Q000032:analysis; D013059:Spectrum Analysis, Raman / Q000379:methods*; D013171:Spores, Bacterial / Q000302:isolation & purification
D010848:Picolinic Acids; C004860:dipicolinic acid