title: Fulminant-type malignant hyperthermia in Japan: cumulative analysis of 383 cases.
abstract: We investigated the transition of clinical signs of fulminant-type malignant hyperthermia (f-MH) by analyzing a database consisting of 383 cumulative cases of f-MH from 1961 to 2004. The cases were divided by time period into group 1 (1961-1984), group 2 (1985-1994), and group 3 (1995-2004). The variables considered were age, sex, type of agents used (succinylcholine and volatile anesthetics), dantrolene administration, clinical signs, laboratory data, and mortality. The level of statistical significance was considered to be less than 5%. Groups 1, 2, and 3 consisted of 196, 127, and 60 cases, respectively. In groups 1, 2, and 3, the rates of dantrolene administration were 18.4%, 93.6%, and 86.7%; the rates of occurrence of ventricular arrhythmia were: 75.2%, 55.6%, and 35.0%; and the rates of generalized muscle rigidity were 64.7%, 60.9%, and 23.9%, respectively. The mortality rate decreased over time, from 42.3% in group 1, to 15.0% in group 2 and group 3. We considered that this decrease occurred because of the increased use of dantrolene and the early diagnosis of malignant hyperthermia in the latter two groups.
authors: Department of Anesthesiology and Critical Care, Hiroshima University Hospital, 1-2-3 Kasumi, Hiroshima 734-8551, Japan.
authors: Takako
authors: T
authors: Migita
authors: Keiko
authors: K
authors: Mukaida
authors: Masashi
authors: M
authors: Kawamoto
authors: Masako
authors: M
authors: Kobayashi
authors: Osafumi
authors: O
authors: Yuge
mesh_terms: D000777:Anesthetics / Q000627:therapeutic use; D003620:Dantrolene / Q000627:therapeutic use; D005260:Female; D006801:Humans; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D008297:Male; D008305:Malignant Hyperthermia / Q000188:drug therapy / Q000453:epidemiology*; D012008:Recurrence
chemical_list: D000777:Anesthetics; D003620:Dantrolene