Human SIRT1: a potential biomarker for tumorigenesis?
Accumulating body of evidence reveals that hSIRT1, an NAD(+)-dependent protein deacetylase, is involved in regulating numerous biological processes. Therefore cellular functions of hSIRT1 are highly pleiotropic. The integrated hypothetical mechanisms of hSIRT1 action contributing to regulating cellular senescence and longevity have been proposed. Based on recent evidence, I propose that hSIRT1 is a potential biomarker for tumorigenesis.
Lim
Chang-Su
CS
Department of Biochemistry, Virginia Tech, Blacksburg, VA 24061, USA. lim@vt.edu
D014408:Biomarkers, Tumor / Q000378:metabolism*; D004249:DNA Damage; D006801:Humans; D051741:Kruppel-Like Transcription Factors / Q000378:metabolism; D008954:Models, Biological; D011485:Protein Binding; D056564:Sirtuin 1; D037761:Sirtuins / Q000378:metabolism*; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
D014408:Biomarkers, Tumor; C499808:HIC1 protein, human; D051741:Kruppel-Like Transcription Factors; D016159:Tumor Suppressor Protein p53; C447939:SIRT1 protein, human; D056564:Sirtuin 1; D037761:Sirtuins