Chromatin regulation and sex determination in Caenorhabditis elegans.
Glioma-associated oncogene (GLI) transcription factors function downstream of the hedgehog signal transduction pathway to regulate the development of many animals. Although the nematode Caenorhabditis elegans lacks a hedgehog pathway, it does have a GLI protein that represses male development in favor of hermaphrodite development. As we discuss here, recent findings implicate two conserved transcription-repressor complexes in the repression of male-specific genes. This research indicates a possible conserved role for these complexes in either GLI-directed gene repression or sex determination.
Large
Edward E
EE
Department of Genetics, North Carolina State University, Raleigh, NC 27695-7614, USA.
Mathies
Laura D
LD
D000818:Animals; D017173:Caenorhabditis elegans; D029742:Caenorhabditis elegans Proteins / Q000502:physiology; D002843:Chromatin / Q000378:metabolism*; D008297:Male; D008954:Models, Biological; D008957:Models, Genetic; D011485:Protein Binding; D019849:Sex Determination Processes; D012737:Sex Factors; D015398:Signal Transduction; D014158:Transcription, Genetic; D016335:Zinc Fingers
D029742:Caenorhabditis elegans Proteins; D002843:Chromatin