Evaluation of contraceptive activity of methanol extract of Dendrophthoe falcata stem in male albino rats.
The present study was undertaken to evaluate the contraceptive efficacy of methanol extract of Dendrophthoe falcata Ettingsh (family-Loranthaceae), stem in male albino rats as reported in folk remedies. Adult proven fertile male rats were gavaged methanol extract of D. falcata stem at 50, 100 and 200mg/rat/day for 60 days. The activity was compared with standard drug, i.e. Lonidamine. On day 61 the animals were autopsied and the testes, epididymides, seminal vesicle and ventral prostate were dissected out and weighed. Sperm motility and density and serum testosterone level were assessed. The sperm motility and density were significantly reduced. The histoarchitecture of testes revealed degenerative changes in the seminiferous tubules, arrest of spermatogenesis at the stage of round spermatid. Serum testosterone levels were decreased significantly in all treatment groups. It is concluded that D. falcata methanol stem extract showed a significant effect on fertility in male rats as reported in folk remedies.
Gupta
R S
RS
Reproductive Physiology Section, Center of Advanced Studies, Department of Zoology, University of Rajasthan, Jaipur 302004, India. gupta_rs@hotmail.com
Kachhawa
J B S
JB
D000818:Animals; D003272:Contraceptive Agents, Male / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005837:Genitalia, Male / Q000166:cytology / Q000187:drug effects; D007191:Indazoles / Q000494:pharmacology; D028183:Loranthaceae; D008297:Male; D000432:Methanol; D009929:Organ Size / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal; D051381:Rats; D012997:Solvents; D013094:Spermatozoa / Q000166:cytology / Q000187:drug effects / Q000502:physiology; D013739:Testosterone / Q000097:blood
D003272:Contraceptive Agents, Male; D007191:Indazoles; D010936:Plant Extracts; D012997:Solvents; D013739:Testosterone; C016371:lonidamine; D000432:Methanol