[Blood lipid-regulation of stilbene glycoside from polygonum multiflorum].
OBJECTIVE
To study lipid-regulating action of 2, 3, 5, 4'-tetrahydroxy stilbene-2-O-beta-D-glucopyranoside (TSG) from Polygonum multiflorum on experimental model hyperlipidemic rats.


METHODS
TSG 90 and 180 mg x kg(-10 x d(-1), atorvastatin mg kg(-1) x d(-1) and saline 2 mL x d(-1) were administered to hyperlipidemic rats. Groups of rats were determined and compared with those of saline group. The LDLR and HMGR mRNA expression were also detected.


RESULTS
TSG significantly reduced serum TC and LDL-C level and atherosclerosis index, increased the expression of LDLR in the liver cells.


CONCLUSIONS
TSG, which shows effects and mechanism in part like atorcastatin, is a major constituent with blood-lipid regulating effect of P. multiflorum and can be explored as a potent medication for hyperlipidemia. Effects on LDL-C and AI, as well as on gene expression of TSG were first reported.
Gao
Xuan
X
Tropical Medicine Institute, Guangzhou University of Chinese Medicine, Guangzhou 510405, China.
Hu
Ying-Jie
YJ
Fu
Lin-Chun
LC
D000818:Animals; D000924:Anticholesteremic Agents / Q000008:administration & dosage / Q000494:pharmacology; D000069059:Atorvastatin; D008078:Cholesterol, LDL / Q000097:blood; D005960:Glucosides / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D022781:Hepatocytes / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D006538:Heptanoic Acids / Q000008:administration & dosage / Q000494:pharmacology; D006903:Hydroxymethylglutaryl CoA Reductases / Q000096:biosynthesis / Q000235:genetics; D006949:Hyperlipidemias / Q000097:blood* / Q000517:prevention & control; D008297:Male; D035281:Plant Tubers / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D028502:Polygonum / Q000737:chemistry*; D011758:Pyrroles / Q000008:administration & dosage / Q000494:pharmacology; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D011973:Receptors, LDL / Q000096:biosynthesis / Q000235:genetics; D013267:Stilbenes / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D014280:Triglycerides / Q000097:blood
C489707:2',3',4',5'-tetrahydroxystilbene-2-O-beta-D-glucoside; D000924:Anticholesteremic Agents; D008078:Cholesterol, LDL; D005960:Glucosides; D006538:Heptanoic Acids; D011758:Pyrroles; D012333:RNA, Messenger; D011973:Receptors, LDL; D013267:Stilbenes; D014280:Triglycerides; D000069059:Atorvastatin; D006903:Hydroxymethylglutaryl CoA Reductases