Junctional adhesion molecule C (JAM-C) distinguishes CD27+ germinal center B lymphocytes from non-germinal center cells and constitutes a new diagnostic tool for B-cell malignancies.
Differentiation of naïve B cells into plasma cells or memory cells occurs in the germinal centers (GCs) of lymph follicles or alternatively via a GC- and T-cell-independent pathway. It is currently assumed that B-cell lymphomas correlate to normal B-cell differentiation stages, but the precise correlation of several B-cell lymphomas to these two pathways remains controversial. In the present report, we describe the junctional adhesion molecule C (JAM-C), currently identified at the cell-cell border of endothelial cells, as a new B-cell marker with a tightly regulated expression during B-cell differentiation. Expression of JAM-C in tonsils allows distinction between two CD27+ B-cell subpopulations: JAM-C- GC B cells and JAM-C+ non-germinal B cells. The expression of JAM-C in different B-cell lymphomas reveals a disease-specific pattern and allows a clear distinction between JAM-C- lymphoproliferative syndromes (chronic lymphocytic leukemia, mantle cell lymphoma and follicular lymphoma) and JAM-C+ ones (hairy cell leukemia, marginal zone B-cell lymphoma). Therefore, we propose JAM-C as a new identification tool in B-cell lymphoma diagnosis.
Ody
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C
Department of Pathology and Immunology, University Medical Center, Geneva, Switzerland.
Jungblut-Ruault
S
S
Cossali
D
D
Barnet
M
M
Aurrand-Lions
M
M
Imhof
B A
BA
Matthes
T
T
D001402:B-Lymphocytes / Q000166:cytology*; D014408:Biomarkers, Tumor; D015815:Cell Adhesion Molecules / Q000032:analysis*; D018858:Germinal Center / Q000166:cytology*; D006801:Humans; D015448:Leukemia, B-Cell / Q000175:diagnosis* / Q000473:pathology; D016393:Lymphoma, B-Cell / Q000175:diagnosis* / Q000473:pathology; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7
D014408:Biomarkers, Tumor; D015815:Cell Adhesion Molecules; C448000:JAM3 protein, human; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7