title: Hypoadiponectinemia as a predictor for the development of hypertension: a 5-year prospective study.
abstract: Low circulating levels of adiponectin, an adipokine with insulin-sensitizing, antiatherogenic, and anti-inflammatory properties, are found in hypertensive patients. Adiponectin replenishment ameliorated hypertension in adiponectin-deficient mice or obese, hypertensive mice with hypoadiponectinemia, suggesting an etiologic role of adiponectin in hypertension. We aimed to determine, in this 5-year prospective study, whether hypoadiponectinemia could predict the development of hypertension in a nondiabetic Chinese cohort. A total of 577 subjects (249 men and 328 women) were recruited from the population-based Hong Kong Cardiovascular Risk Factor Prevalence Study and prospectively followed up for 5 years. The relationship of serum adiponectin with the development of hypertension (sitting blood pressure >or=140/90 mm Hg) was investigated in a nested case-control study consisting of 70 subjects who had developed hypertension on follow-up and 140 age- and sex-matched control subjects who were normotensive both at baseline and at year 5. At baseline, serum adiponectin level in the lowest sex-specific tertile was more likely to be associated with hypertension (P=0.003 versus the highest tertile, after adjusting for age, body mass index, fasting insulin, and high-sensitivity C-reactive protein). At year 5, baseline serum adiponectin was a significant independent predictor of incident hypertension in the nested case-control study (P=0.015; age adjusted), together with mean arterial pressure (P<0.001), high-sensitivity C-reactive protein (P=0.018), and body mass index (P=0.004). Normotensive subjects with baseline serum adiponectin levels in the lowest sex-specific tertile had an increased risk of becoming hypertensive (adjusted odds ratio: 2.76; 95% CIs: 1.06 to 7.16; P=0.037 versus highest tertile). Our data suggest that hypoadiponectinaemia may be involved in the pathogenesis of hypertension in humans.
authors: Department of Medicine, University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Rd, Hong Kong, People's Republic of China.
authors: Wing-Sun
authors: WS
authors: Chow
authors: Bernard M Y
authors: BM
authors: Cheung
authors: Annette W K
authors: AW
authors: Tso
authors: Aimin
authors: A
authors: Xu
authors: Nelson M S
authors: NM
authors: Wat
authors: Carol H Y
authors: CH
authors: Fong
authors: Liza H Y
authors: LH
authors: Ong
authors: Sidney
authors: S
authors: Tam
authors: Kathryn C B
authors: KC
authors: Tan
authors: Edward D
authors: ED
authors: Janus
authors: Tai-Hing
authors: TH
authors: Lam
authors: Karen S L
authors: KS
authors: Lam
mesh_terms: D052242:Adiponectin / Q000097:blood*; D050154:Adiposity / Q000502:physiology; D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000502:physiology; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000453:epidemiology*; D007333:Insulin Resistance / Q000502:physiology; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood* / Q000150:complications*; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012307:Risk Factors
chemical_list: D052242:Adiponectin