DOK4/IRS-5 expression is altered in clear cell renal cell carcinoma.
The insulin-receptor substrate family plays important roles in cellular growth, signaling, and survival. We have previously shown the dysregulation of the IGF-axis in clear cell renal cell carcinoma. In this manuscript, we examine the expression of the insulin receptor substrate family in clear cell RCC, and demonstrate that the expression of 2 members of this family are significantly altered in tumors. The most striking finding is that expression of the new IRS family member IRS-5 is significantly upregulated in 90% of examined clear cell RCCs. Studies on this gene has shown that it is regulated through chromatin remodeling in kidney cells.
Al-Sarraf
Nael
N
Department of Clinical Medicine, Thoracic Oncology Research Group, Institute of Molecular Medicine, Trinity Centre for Health Sciences, St James's Hospital, Dublin 8, Ireland.
Reiff
Johanne Nørvig
JN
Hinrichsen
Jane
J
Mahmood
Shaukat
S
Teh
Bin Tean
BT
McGovern
Eilish
E
De Meyts
Pierre
P
O'byrne
Kenneth J
KJ
Gray
Steven G
SG
D000107:Acetylation; D048868:Adaptor Proteins, Signal Transducing; D001483:Base Sequence; D002292:Carcinoma, Renal Cell / Q000235:genetics*; D002460:Cell Line; D015342:DNA Probes; D019143:Evolution, Molecular; D005260:Female; D006657:Histones / Q000378:metabolism; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics*; D007680:Kidney Neoplasms / Q000235:genetics*; D008297:Male; D008969:Molecular Sequence Data; D010750:Phosphoproteins / Q000235:genetics*; D010802:Phylogeny; D020133:Reverse Transcriptase Polymerase Chain Reaction
D048868:Adaptor Proteins, Signal Transducing; D015342:DNA Probes; C486625:DOK4 protein, human; D006657:Histones; D047908:Intracellular Signaling Peptides and Proteins; D010750:Phosphoproteins