title: Modifiers of epigenetic reprogramming show paternal effects in the mouse.
abstract: There is increasing evidence that epigenetic information can be inherited across generations in mammals, despite extensive reprogramming both in the gametes and in the early developing embryo. One corollary to this is that disrupting the establishment of epigenetic state in the gametes of a parent, as a result of heterozygosity for mutations in genes involved in reprogramming, could affect the phenotype of offspring that do not inherit the mutant allele. Here we show that such effects do occur following paternal inheritance in the mouse. We detected changes to transcription and chromosome ploidy in adult animals. Paternal effects of this type have not been reported previously in mammals and suggest that the untransmitted genotype of male parents can influence the phenotype of their offspring.
authors: Epigenetics Laboratory, Queensland Institute of Medical Research, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia.
authors: Suyinn
authors: S
authors: Chong
authors: Nicola
authors: N
authors: Vickaryous
authors: Alyson
authors: A
authors: Ashe
authors: Natasha
authors: N
authors: Zamudio
authors: Neil
authors: N
authors: Youngson
authors: Sarah
authors: S
authors: Hemley
authors: Tomas
authors: T
authors: Stopka
authors: Arthur
authors: A
authors: Skoultchi
authors: Jacqui
authors: J
authors: Matthews
authors: Hamish S
authors: HS
authors: Scott
authors: David
authors: D
authors: de Kretser
authors: Moira
authors: M
authors: O'Bryan
authors: Marnie
authors: M
authors: Blewitt
authors: Emma
authors: E
authors: Whitelaw
mesh_terms: D000251:Adenosine Triphosphatases; D054366:Agouti Signaling Protein / Q000235:genetics; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002868:Chromosomal Proteins, Non-Histone; D003433:Crosses, Genetic; D019175:DNA Methylation; D004252:DNA Mutational Analysis; D044127:Epigenesis, Genetic / Q000235:genetics*; D005434:Flow Cytometry; D040461:Gene Components; D018507:Gene Expression Regulation, Developmental; D007150:Immunohistochemistry; D040582:Inheritance Patterns / Q000235:genetics*; D008297:Male; D051379:Mice / Q000235:genetics*; D008969:Molecular Sequence Data; D020411:Oligonucleotide Array Sequence Analysis; D010641:Phenotype; D017354:Point Mutation / Q000235:genetics; D016415:Sequence Alignment; D013091:Spermatogenesis / Q000235:genetics
chemical_list: D054366:Agouti Signaling Protein; D002868:Chromosomal Proteins, Non-Histone; C515183:a protein, mouse; D000251:Adenosine Triphosphatases; C498725:Smarca5 protein, mouse