Serum adiponectin level as an independent predictor of mortality in patients with congestive heart failure.
BACKGROUND
Congestive heart failure (CHF) is associated with altered energy homeostasis and myocardial inflammation, hypertrophy, and fibrosis. Adiponectin, an insulin-sensitizing adipocytokine, may affect these pathogenic factors, and the circulating adiponectin level may serve as a biological marker of CHF. This study aimed to assess the significance of serum adiponectin as a prognostic marker for Japanese CHF patients.


RESULTS
The serum adiponectin levels were compared between 54 (24 ischemic and 30 non-ischemic) CHF patients with left ventricular systolic dysfunction and 55 age- and gender-matched control subjects. The CHF patients also underwent simultaneous clinical assessment and measurements for brain natriuretic peptide (BNP) and parameters of lipid or glucose metabolism. Compared with the controls, the CHF patients showed significantly increased serum adiponectin levels [6.7 (4.9-12.6) vs 14.6 (9.7-25.4) microg/ml, p<0.0001]. In the CHF patients, the log-transformed values of the serum adiponectin levels positively correlated with the log-transformed values of the plasma BNP levels (p=0.0003, r=0.48) and inversely correlated with the body mass index (p=0.0006, r=-0.46). Furthermore, an increase in the serum adiponectin level was associated with higher mortality (p<0.05), particularly in the ischemic CHF patients (p<0.005).


CONCLUSIONS
An increase in the circulating adiponectin level was associated with higher mortality in the ischemic CHF patients. Adiponectin may be an informative risk marker for Japanese CHF patients.
Tamura
Toshihiro
T
Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, Japan.
Furukawa
Yutaka
Y
Taniguchi
Ryoji
R
Sato
Yukihito
Y
Ono
Koh
K
Horiuchi
Hisanori
H
Nakagawa
Yoshihisa
Y
Kita
Toru
T
Kimura
Takeshi
T
D052242:Adiponectin / Q000097:blood*; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D005260:Female; D006333:Heart Failure / Q000097:blood* / Q000150:complications / Q000208:ethnology / Q000401:mortality*; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000150:complications; D020097:Natriuretic Peptide, Brain / Q000097:blood; D011237:Predictive Value of Tests; D016016:Proportional Hazards Models; D018487:Ventricular Dysfunction, Left / Q000150:complications
D052242:Adiponectin; D015415:Biomarkers; D020097:Natriuretic Peptide, Brain