Group A streptococcal infections in children.
The group A streptococcus causes the widest range of disease in humans of all bacterial pathogens. Group A streptococcal diseases are more common in children than adults with diseases ranging from pharyngitis and impetigo to invasive infections and the post-streptococcal sequelae--acute rheumatic fever and acute post-streptococcal glomerulonephritis. The global burden of severe group A streptococcal disease is concentrated largely in developing countries and Indigenous populations such as Aboriginal Australians. Control of group A streptococcal disease is poor in these settings and the need for a vaccine has been argued. With an ever-increasing understanding of the group A streptococcus at a molecular level, new and sophisticated vaccines are currently in human trials and the next decade holds exciting prospects for curbing group A streptococcal diseases.
Steer
Andrew C
AC
Centre for International Child Health, University of Melbourne, Department of Paediatrics, Murdoch Childrens Research Institute, Royal Children's Hospital, Melbourne, Victoria, Australia.
Danchin
Margaret H
MH
Carapetis
Jonathan R
JR
D002675:Child, Preschool; D005921:Glomerulonephritis / Q000188:drug therapy / Q000453:epidemiology / Q000503:physiopathology; D006801:Humans; D010612:Pharyngitis / Q000188:drug therapy / Q000453:epidemiology / Q000503:physiopathology; D011203:Poverty; D011711:Pyoderma / Q000188:drug therapy / Q000453:epidemiology / Q000503:physiopathology; D012213:Rheumatic Fever / Q000188:drug therapy / Q000453:epidemiology / Q000503:physiopathology; D013290:Streptococcal Infections / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology / Q000276:immunology / Q000503:physiopathology; D022541:Streptococcal Vaccines; D013297:Streptococcus pyogenes / Q000472:pathogenicity*; D014739:Victoria
D022541:Streptococcal Vaccines