title: Is KPNB3 locus associated with schizophrenia?
abstract: OBJECTIVE
  To reconfirm the association of KPNB3 with schizophrenia in Chinese population.
  
  
  METHODS
  Two single nucleotide polymorphisms (SNPs), rs2588014 and rs626716 at the KPNB3 locus, were genotyped in 304 Chinese Han family trios consisting of fathers, mothers, and affected offsprings with schizophrenia. These 2 SNPs were detected by PCR-based restriction fragment length polymorphism (RFLP) analysis. The Hardy-Weinberg equilibrium for genotypic distributions was estimated by the goodness-of-fit test. The UNPHASED program was used to perform transmission disequilibrium test (TDT), haplotype analysis, and pair-wise measure of linkage disequilibrium (LD) between these 2 SNPs.
  
  
  RESULTS
  The genotypic distributions of both rs2588014 and rs626716 were in the Hardy-Weinberg equilibrium (P > 0.05). The TDT revealed allelic association with rs626716 (chi2 = 9.31, P = 0.0023) but not with rs2588014 (chi2 = 3.44, P = 0.064). The global P-value was 0.0099 for 100 permutations. The haplotype analysis also showed a disease association (chi2 = 25.97, df = 3, P = 0.0000097).
  
  
  CONCLUSIONS
  The present study provides further evidence in support of the KPNB3 association with schizophrenia in Chinese population.
authors: Research Center for Genomic Medicine, School of Public Health, Jilin University, Changchun, China.
authors: Li-Bo
authors: LB
authors: Liu
authors: Ying
authors: Y
authors: Hu
authors: Gui-Zhi
authors: GZ
authors: Ju
authors: Xuan
authors: X
authors: Zhang
authors: Lin
authors: L
authors: Xie
authors: Shu-Zheng
authors: SZ
authors: Liu
authors: Jie-Ping
authors: JP
authors: Shi
authors: Ya-Qin
authors: YQ
authors: Yu
authors: Qi
authors: Q
authors: Xu
authors: Yu
authors: Y
authors: Fan
authors: Yan
authors: Y
authors: Shen
authors: Jun
authors: J
authors: Wei
mesh_terms: D000328:Adult; D002681:China / Q000453:epidemiology; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D012559:Schizophrenia / Q000453:epidemiology / Q000235:genetics*; D028961:beta Karyopherins / Q000235:genetics*
chemical_list: C107940:IPO5 protein, human; D028961:beta Karyopherins