title: Experimental and clinical significance of antinuclear antibodies in liver transplantation.
abstract: Histone H1 and high-mobility group box 1 (HMGB1) proteins are known to initiate an immune reaction, and the corresponding antibodies (Abs) possess immunosuppressive activity. In the present study, we aimed to evaluate the immunological role of antinuclear Abs in experimental and clinical liver transplantation. In a rat tolerogenic orthotopic liver transplantation (OLT) model, antihistone H1 and HMGB1 titers were induced during the rejection and tolerance induction phases, respectively. Those Ab responses also were confirmed in a drug-induced tolerance model (acute rejection model + cyclosporin A [0 to 14 days after OLT]). We also found a similar tendency in our clinical drug-free patient (who experienced complete cessation of any immunosuppressive treatments) and that antinuclear Abs induced in the serum after cessation of immunosuppressants play a part of immune privilege in this patient. These results suggest that antinuclear Abs are important factors for overcoming rejection and the subsequent tolerance induction in liver transplantation.
authors: Department of Surgery, Liver Transplantation Program, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
authors: Toshiaki
authors: T
authors: Nakano
authors: Shigeru
authors: S
authors: Goto
authors: Chia-Yun
authors: CY
authors: Lai
authors: Li-Wen
authors: LW
authors: Hsu
authors: Ying-Hsien
authors: YH
authors: Kao
authors: Yu-Chun
authors: YC
authors: Lin
authors: Seiji
authors: S
authors: Kawamoto
authors: Kuei-Chen
authors: KC
authors: Chiang
authors: Naoya
authors: N
authors: Ohmori
authors: Takeshi
authors: T
authors: Goto
authors: Shuji
authors: S
authors: Sato
authors: Bruno
authors: B
authors: Jawan
authors: Yu-Fan
authors: YF
authors: Cheng
authors: Kazuhisa
authors: K
authors: Ono
authors: Chao-Long
authors: CL
authors: Chen
mesh_terms: D000818:Animals; D000974:Antibodies, Antinuclear / Q000276:immunology*; D034961:Antigens, Nuclear / Q000276:immunology; D024243:HMGB1 Protein / Q000276:immunology; D006657:Histones / Q000276:immunology; D006801:Humans; D016031:Liver Transplantation / Q000276:immunology*; D023421:Models, Animal; D051381:Rats
chemical_list: D000974:Antibodies, Antinuclear; D034961:Antigens, Nuclear; D024243:HMGB1 Protein; D006657:Histones