title: Glutathione-S-transferase genotypes influence prognosis in follicular non-Hodgkin's Lymphoma.
abstract: Polymorphisms in detoxification enzymes of the glutathione S-transferase (GST) family have been associated with risk and prognosis of several cancer types. We studied deletions of GSTM1 and GSTT1, and the GSTP1 Ile(105)Val polymorphism in 89 patients with follicular lymphoma (FL). Patients with a GSTM1 or GSTT1 deletion had a significantly worse event-free survival, when compared with patients with undeleted genotype (p = 0.03 and p = 0.03, respectively). Outcome was even worse in patients with a double negative genotype, in comparison with patients with only one GST deletion or normal genotype (p = 0.01). In the multivariate analysis, the GSTM1/GSTT1 genotype tended to have a prognostic significance independent from the Follicular Lymphoma International Prognostic Index (FLIPI) score. In particular, GSTM1/T1 deletions identified patients with negative prognosis in the low (<3) FLIPI score group (p = 0.01). Larger prospective studies including homogeneously treated patients will be needed to confirm these results.
authors: Istituto di Ematologia, Universita' Cattolica S, Cuore, Rome, Italy. stefan.hohaus@rm.unicatt.it
authors: Stefan
authors: S
authors: Hohaus
authors: Giovanna
authors: G
authors: Mansueto
authors: Giuseppina
authors: G
authors: Massini
authors: Francesco
authors: F
authors: D'Alo
authors: Manuela
authors: M
authors: Giachelia
authors: Maurizio
authors: M
authors: Martini
authors: Luigi Maria
authors: LM
authors: Larocca
authors: Maria Teresa
authors: MT
authors: Voso
authors: Giuseppe
authors: G
authors: Leone
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D017353:Gene Deletion; D005838:Genotype; D051549:Glutathione S-Transferase pi / Q000235:genetics*; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D008224:Lymphoma, Follicular / Q000175:diagnosis / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011379:Prognosis; D012307:Risk Factors
chemical_list: D051549:Glutathione S-Transferase pi; D005982:Glutathione Transferase; C413545:glutathione S-transferase T1; C496556:GSTP1 protein, human