title: Effect of i.v. injection of radiographic contrast media on human renal blood flow.
abstract: OBJECTIVE
  The purpose of our study was to assess the effect of an i.v. injection of iodinated radiographic contrast medium on human renal blood flow using cine phase-contrast MRI.
  
  
  METHODS
  We examined 12 healthy adult volunteers. Blood flow in one renal artery was measured using cine phase-contrast imaging (1.5-T MR system). Each volunteer received 120 mL of isotonic sodium chloride on study day 1 and 120 mL of a low-osmolar, nonionic, iodinated contrast medium (iomeprol, 400 mg I/mL) on study day 2. Repetitive measurements were performed before (up to five measurements in 5 minutes) and after (up to 13 measurements in 30 minutes) the injection was started.
  
  
  RESULTS
  Mean basal renal artery blood flow was 664 mL/min. In response to the injection of the test substances, we found a significantly larger decrease in average renal blood flow for contrast medium than for sodium chloride (31.9 mL/min vs 18.3 mL/min, p = 0.0481). Furthermore, in analyzing the measurements at early time points, we found a significant decrease (11.4% +/- 4.7% [SD]; Bonferroni-corrected, p < 0.05) in renal blood flow 2 minutes after the injection of the contrast medium was started. Sodium chloride did not produce a significant effect at any time.
  
  
  CONCLUSIONS
  Cine phase-contrast MRI can measure a decrease in renal blood flow in humans in response to an i.v. injection of iodinated radiographic contrast medium. Therefore, cine phase-contrast MRI can be a helpful and noninvasive tool for further investigations of contrast media-induced changes in human renal blood flow and their possible impact on the development of contrast-induced nephropathy.
authors: Department of Diagnostic Radiology, Justus-Liebig-University, Klinikstrasse 36, 35392 Giessen, Hessen, Germany.
authors: Nils
authors: N
authors: Hackstein
authors: Christian
authors: C
authors: Schneider
authors: Gerrit
authors: G
authors: Eichner
authors: Wigbert S
authors: WS
authors: Rau
mesh_terms: D000328:Adult; D003287:Contrast Media / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D017613:Iodine Compounds / Q000008:administration & dosage / Q000494:pharmacology*; D008279:Magnetic Resonance Imaging; D008297:Male; D012039:Regional Blood Flow / Q000187:drug effects; D012079:Renal Circulation / Q000187:drug effects*
chemical_list: D003287:Contrast Media; D017613:Iodine Compounds