Tachykinin receptor 1 variants associated with aggression in suicidal behavior.
Substance P is involved in the modulation of depression, anxiety, and suicidal-related behaviors. We studied gene variants of Tachykinin Receptor 1 (TACR1-rs3771810, rs3771825, rs726506, rs1477157) in 167 German suicide attempters (affective spectrum n = 107, schizophrenia spectrum n = 35, borderline personality disorder n = 25), 92 Caucasian individuals who committed suicide and 312 German healthy subjects. Single markers and haplotype analysis in relation to suicidal behaviors (suicide attempters/completers) did not reveal any significant association. The rarest rs3771825 T allele however showed a marginal association with higher Reactive Aggression scores on the Questionnaire for Measuring Factors of Aggression (FAF) (F = 9.86, df = 1; P = 0.0017). Haplotype analyses confirmed the finding. Violence or impulsivity of suicide attempt and State-Trait Anger Expression Inventory (STAXI) scores were not associated with gene variants. In conclusion, our study suggests that TACR1 gene variants have no major influence on suicidal behavior but may modulate aggression features.
Giegling
Ina
I
Department of Psychiatry, Ludwig Maximilians University, Munich, Germany.
Rujescu
Dan
D
Mandelli
Laura
L
Schneider
Barbara
B
Hartmann
Annette M
AM
Schnabel
Axel
A
Maurer
Konrad
K
De Ronchi
Diana
D
Möller
Hans-Jürgen
HJ
Serretti
Alessandro
A
D000293:Adolescent; D000328:Adult; D000368:Aged; D000374:Aggression / Q000502:physiology*; D016022:Case-Control Studies; D005260:Female; D014644:Genetic Variation; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D018039:Receptors, Tachykinin / Q000235:genetics*; D013405:Suicide / Q000523:psychology; D013406:Suicide, Attempted / Q000523:psychology
D018039:Receptors, Tachykinin