title: [Metabolic profile according to leptin levels in obese patients].
abstract: Increased body mass index and waist circumference are related to cardiovascular risk factors. Leptin is an adipocyte-produced hormone and regulates body weight. Leptin is directly related to body fat. To evaluate the relationship between leptin and metabolic profile in obese subjects, we studied 119 patients. Anthropometric, laboratory, body composition (by bioelectrical impedance) and co-morbidity data were collected. The analysis was performed in the female population (86.6%): average age: 42 +/- 13 years; hypertension, type 2 diabetes and grade III obesity were present in 61.9%, 20.2% and 58.3%, respectively. Leptin levels were positively related to insulin resistance (IR). HOMA-IR was related to metabolic abnormalities of IR. No differences were demonstrated between lipid profile, glycemia, body composition and tertiles of leptin corrected by fat weight. A significant difference in HOMA-IR was present when the 2nd and 3rd tertiles of leptin corrected by fat weight [3.4 (2.8-4.1) vs. 5.3 (4.1-6.5), p=0.011] were compared. In conclusion, leptin corrected by fat weight did not influence lipid profile and glycemia in moderate to severe obese women with similar percent body fat. Leptin should not be considered an independent factor affecting lipid metabolism.
authors: Grupo de Obesidade e Síndrome Metabólica, Serviço de Endocrinologia, Hospital das Clínicas, Universidade de São Paulo. alinafeitosa@yahoo.com.br
authors: Alina C R
authors: AC
authors: Feitosa
authors: Márcio C
authors: MC
authors: Mancini
authors: Cíntia
authors: C
authors: Cercato
authors: Sandra M
authors: SM
authors: Villares
authors: Alfredo
authors: A
authors: Halpern
mesh_terms: D050154:Adiposity / Q000502:physiology; D000328:Adult; D015415:Biomarkers / Q000032:analysis; D015992:Body Mass Index; D005260:Female; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D020738:Leptin / Q000032:analysis*; D050356:Lipid Metabolism / Q000502:physiology*; D008875:Middle Aged; D009765:Obesity / Q000378:metabolism*; D012307:Risk Factors; D050151:Subcutaneous Fat / Q000378:metabolism*; D049629:Waist-Hip Ratio
chemical_list: D015415:Biomarkers; D020738:Leptin