title: Smallest peptoids with antiproliferative activity on human neoplastic cells.
abstract: Libraries of new, small peptoid monomers and dipeptoids were synthesized and assayed for antiproliferative activity against representative human neoplastic cell lines. The C-terminal N-alkyl amide peptoids are cytotoxic and are the smallest peptoids reported to have such activity. These compounds were conveniently synthesized on a BAL resin. Owing to their structure, the peptoids did not suffer from DKP formation, a problematic side reaction typically observed in peptide and peptoid synthesis.
authors: Institute for Research in Biomedicine, Barcelona Science Park, University of Barcelona, Barcelona, Spain.
authors: Carlos
authors: C
authors: Mas-Moruno
authors: Luis J
authors: LJ
authors: Cruz
authors: Puig
authors: P
authors: Mora
authors: Andrés
authors: A
authors: Francesch
authors: Angel
authors: A
authors: Messeguer
authors: Enrique
authors: E
authors: Pérez-Paya
authors: Fernando
authors: F
authors: Albericio
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D020650:Combinatorial Chemistry Techniques; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D034444:Peptoids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D012995:Solubility; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D034444:Peptoids