Baccharis dracunculifolia, the main botanical source of Brazilian green propolis, displays antiulcer activity.
Baccharis dracunculifolia is the most important botanical source of Southeastern Brazilian propolis, known as green propolis for its colour. In a previous study, we described the gastric protective effect of the hydroalcoholic extract of Brazilian green propolis. We therefore wanted to investigate the possibility of using B. dracunculifolia extract for antiulcer treatment. This study was undertaken to evaluate the anti-ulcerogenic property of hydroalcoholic extract of B. dracunculifolia aerial parts. The HPLC analysis of the chemical composition of B. dracunculifolia extract used in this study revealed the presence mainly of cinnamic acid derivates and flavonoids. Doses of 50, 250 and 500 mg/kg of B. dracunculifolia crude extract and positive controls (omeprazole or cimetidine) significantly diminished the lesion index, the total lesion area and the percentage of lesion compared with negative control groups. The percentage of ulcer inhibition was significantly higher in groups treated with B. dracunculifolia, cimetidine or omeprazole, with all protocols used, compared with negative control groups. Regarding the model of gastric secretion, reductions in the volume of gastric juice and total acidity were observed, as well as an increase in the gastric pH. These results were similar to results from studies carried out with green propolis extract. Although more investigations are required, our results suggest that B. dracunculifolia has potential to be used as a phytotherapic preparation for the treatment of gastric ulcer.
Lemos
Marivane
M
Núcleo de Ciência e Tecnologia, Area de Ciências Biológicas e da Saúde, Universidade do Oeste de Santa Catarina, Campus de Videira, Rua Paese, 198, Bairro das Torres, Videira-SC, 89560-000, SC, Brazil.
de Barros
Muriel Primon
MP
Sousa
João Paulo Barreto
JP
da Silva Filho
Ademar Alves
AA
Bastos
Jairo Kenupp
JK
de Andrade
Sérgio Faloni
SF
D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D031175:Baccharis / Q000737:chemistry*; D001938:Brazil; D002851:Chromatography, High Pressure Liquid; D002927:Cimetidine / Q000494:pharmacology; D002934:Cinnamates / Q000302:isolation & purification* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology*; D005745:Gastric Acidity Determination; D005750:Gastric Juice / Q000187:drug effects; D006863:Hydrogen-Ion Concentration / Q000187:drug effects; D008297:Male; D009853:Omeprazole / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D018515:Plant Leaves; D010946:Plants, Medicinal; D011429:Propolis; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy*
D000897:Anti-Ulcer Agents; D002934:Cinnamates; D005419:Flavonoids; D010936:Plant Extracts; D002927:Cimetidine; D011429:Propolis; D009853:Omeprazole