title: Abnormalities of cingulate gyrus neuroanatomy in schizophrenia.
abstract: OBJECTIVE
  Abnormalities of the neuroanatomy of the gray matter of the cingulate gyrus, especially its anterior segment, have been suggested to be an important characteristic of schizophrenia. In this study, T1-weighted magnetic resonance scans were collected in 53 individuals with schizophrenia and 68 comparison subjects matched for age, gender, race and parental socioeconomic status. We applied Labeled Cortical Mantle Distance Mapping to assess the volume, surface area and thickness of the cortical mantle within the anterior (AC) and posterior (PC) segments of the cingulate gyrus, excluding the paracingulate gyrus, and related these anatomical measures to measures of psychopathology and illness duration.
  
  
  RESULTS
  After covarying for total cerebral volume, individuals with schizophrenia showed smaller AC gray matter volume (p=0.024), thickness (trend, p=0.081), but not surface area (p=0.16), than comparison subjects. Similar group differences were found for PC gray matter volume (p=0.0005) and thickness (trend, p=0.055), but not surface area (p=0.15). Across both groups, there was a significant L>R asymmetry in thickness of the AC, and a significant L>R asymmetry in the surface area of the PC. However, there were no significant group-by-hemisphere interactions. In the individuals with schizophrenia, thinning of the AC, but not the PC, was correlated with a longer duration of illness and a greater severity of psychotic symptoms.
  
  
  CONCLUSIONS
  Individuals with schizophrenia showed smaller gray matter volumes across the entire cingulate gyrus, mostly due to a reduction in cortical mantle thickness. However, structural measures of the AC were more closely related to clinical features of the illness.
authors: Department of Psychiatry, Washington University School of Medicine, Box 8134, 660 S. Euclid Ave., St. Louis, MO 63110, United States. lei@wustl.edu
authors: Lei
authors: L
authors: Wang
authors: Malini
authors: M
authors: Hosakere
authors: Joshua C L
authors: JC
authors: Trein
authors: Alex
authors: A
authors: Miller
authors: J Tilak
authors: JT
authors: Ratnanather
authors: Deanna M
authors: DM
authors: Barch
authors: Paul A
authors: PA
authors: Thompson
authors: Anqi
authors: A
authors: Qiu
authors: Mokhtar H
authors: MH
authors: Gado
authors: Michael I
authors: MI
authors: Miller
authors: John G
authors: JG
authors: Csernansky
mesh_terms: D000328:Adult; D000368:Aged; D004292:Dominance, Cerebral / Q000502:physiology; D005260:Female; D006179:Gyrus Cinguli / Q000002:abnormalities* / Q000473:pathology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009929:Organ Size / Q000502:physiology; D011569:Psychiatric Status Rating Scales; D012016:Reference Values; D012559:Schizophrenia / Q000175:diagnosis*; D013223:Statistics as Topic