Smart textiles: a new drug delivery system for symptomatic treatment of a common cold.
Smart textiles provide the possibility of being coated with cineole, menthol, and camphor. Due to over-the-counter availability, ethereal oils are frequently used to treat a common cold. The existing pharmaceutical forms entail the risk of oral ingestion by children, which can cause severe intoxications. This risk could be limited by a smart textile application. Prior to applicability tests in children, the principal traceability of smart textile-applied ethereal oils at their site of action in the alveoli has to be demonstrated. Therefore, a crossover trial (ointment vs smart textiles) with 6 healthy volunteers was carried out as a proof-of-concept study. As a result, the principle proof is given that smart textile-applied ethereal oils are available at their site of action. Because of the volatility of the active ingredients, a close-fitting textile form has to be developed for further clinical development of smart textiles to achieve higher concentrations in the alveoli. Slower liberation properties and a more convenient skin sensation in comparison to available pharmaceutical forms may provide advantages for the applicability in both children and adults.
Wienforth
F
F
Institute of Clinical Pharmacology, Medical Faculty, Technical University Dresden, Fiedlerstr. 27, 01307 Dresden, Germany. florian.wienforth@tu-dresden.de
Landrock
A
A
Schindler
C
C
Siegert
J
J
Kirch
W
W
D000279:Administration, Cutaneous; D000328:Adult; D001944:Breath Tests; D002164:Camphor / Q000008:administration & dosage* / Q000493:pharmacokinetics; D018592:Cross-Over Studies; D003511:Cyclohexanols / Q000008:administration & dosage* / Q000493:pharmacokinetics; D016503:Drug Delivery Systems; D000077591:Eucalyptol; D005260:Female; D006801:Humans; D008168:Lung / Q000378:metabolism; D008297:Male; D008610:Menthol / Q000008:administration & dosage* / Q000493:pharmacokinetics; D039821:Monoterpenes / Q000008:administration & dosage* / Q000493:pharmacokinetics; D009824:Ointments; D013784:Textiles
D003511:Cyclohexanols; D039821:Monoterpenes; D009824:Ointments; D008610:Menthol; D002164:Camphor; D000077591:Eucalyptol