GENOME: a rapid coalescent-based whole genome simulator.
CONCLUSIONS
GENOME proposes a rapid coalescent-based approach to simulate whole genome data. In addition to features of standard coalescent simulators, the program allows for recombination rates to vary along the genome and for flexible population histories. Within small regions, we have evaluated samples simulated by GENOME to verify that GENOME provides the expected LD patterns and frequency spectra. The program can be used to study the sampling properties of any statistic for a whole genome study.


BACKGROUND
The program and C++ source code are available online at http://www.sph.umich.edu/csg/liang/genome/
Liang
Liming
L
Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA. lianglim@umich.edu
Zöllner
Sebastian
S
Abecasis
Gonçalo R
GR
D000483:Alleles; D019295:Computational Biology / Q000379:methods*; D003198:Computer Simulation; D005787:Gene Frequency; D016678:Genome; D015894:Genome, Human; D006801:Humans; D008957:Models, Genetic; D009154:Mutation; D011381:Programming Languages; D011995:Recombination, Genetic; D017422:Sequence Analysis, DNA; D012984:Software