title: Polarization-sensitive optical coherence tomography for imaging human atherosclerosis.
abstract: Polarization-sensitive optical coherence tomography (PS-OCT) combines the advantages of OCT with image contrast enhancement, which is based on its ability to detect phase retardation and the fast-axis angle. Both PS-OCT images and histopathology have demonstrated similar features that allowed differentiation of atherosclerotic structures (i.e., plaques) from normal tissue. Moreover, the picrosirius polarization method was used to confirm PS-OCT assessment of collagen in the fibrous cap of atherosclerotic plaques, and high-frequency (40 MHz) ultrasound images were used to identify calcium in the vessel wall. Our preliminary ex vivo investigation of human aortic specimens indicated that PS-OCT might help to identify atherosclerotic lesions.
authors: Institute of Electro-Optical Science and Technology, National Taiwan Normal University, Taipei 116, Taiwan.
authors: Wen-Chuan
authors: WC
authors: Kuo
authors: Nai-Kuan
authors: NK
authors: Chou
authors: Chien
authors: C
authors: Chou
authors: Chih-Ming
authors: CM
authors: Lai
authors: Huan-Jang
authors: HJ
authors: Huang
authors: Shoei-Shen
authors: SS
authors: Wang
authors: Jeou-Jong
authors: JJ
authors: Shyu
mesh_terms: D001011:Aorta / Q000473:pathology*; D003324:Coronary Artery Disease / Q000473:pathology*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D006801:Humans; D007089:Image Enhancement / Q000295:instrumentation* / Q000379:methods; D066298:In Vitro Techniques; D012031:Refractometry / Q000295:instrumentation* / Q000379:methods; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D041623:Tomography, Optical Coherence / Q000295:instrumentation* / Q000379:methods