title: Comparison of urinary and recombinant human chorionic gonadotropin during ovulation induction in intrauterine insemination cycles: a prospective randomized clinical trial.
abstract: OBJECTIVE
  To compare the in vivo effectiveness of recombinant (r) hCG with urinary (u) hCG during controlled ovarian hyperstimulation and intrauterine insemination (COH-IUI) cycles.
  
  
  METHODS
  Prospective controlled clinical study.
  
  
  METHODS
  Private IVF center.
  
  
  METHODS
  Two hundred eighty-four subjects undergoing COH-IUI cycles.
  
  
  METHODS
  Women were randomized into receiving r-hCG or u-hCG for final maturation and induction of ovulation.
  
  
  METHODS
  Clinical pregnancy rate and outcome of pregnancy.
  
  
  RESULTS
  Background characteristics were similar in the two groups studied except for a slight difference in the mean duration of infertility (3.0 vs. 2.3). There was no significant difference in the number of follicles > or =16 mm, mean peak E(2), or mean 1-week P levels between the two groups. The clinical pregnancy rate was 27.1% in the recombinant group compared with 28.5% in the urinary group. The outcome of pregnancy was similar in both groups.
  
  
  CONCLUSIONS
  Recombinant hCG was found to be as effective as u-hCG in achieving pregnancy during COH-IUI cycles. This is in agreement with earlier studies on the effectiveness of r-hCG in IVF cycles.
authors: Synergy Medical Education Alliance, Michigan State University, Saginaw, Michigan, USA.
authors: Khaled
authors: K
authors: Sakhel
authors: Mohamed
authors: M
authors: Khedr
authors: Sandra
authors: S
authors: Schwark
authors: Mohammad
authors: M
authors: Ashraf
authors: Michael H
authors: MH
authors: Fakih
authors: Mostafa
authors: M
authors: Abuzeid
mesh_terms: D006063:Chorionic Gonadotropin / Q000627:therapeutic use / Q000652:urine*; D005260:Female; D006801:Humans; D007315:Insemination, Artificial / Q000379:methods*; D008297:Male; D010053:Ovary / Q000187:drug effects / Q000502:physiology*; D010062:Ovulation Induction; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000453:epidemiology; D018873:Pregnancy Rate; D011446:Prospective Studies; D011994:Recombinant Proteins / Q000627:therapeutic use
chemical_list: D006063:Chorionic Gonadotropin; D011994:Recombinant Proteins