Liver injury induced by a Japanese herbal medicine, sairei-to (TJ-114, Bupleurum and Hoelen Combination, Chai-Ling-Tang) R1.
The case is reported of a man who showed acute hepatitis with jaundice after he was given a Japanese herbal medicine, sairei-to (TJ-114, Bupleurum and Hoelen Combination, Chai-Ling-Tang). Unusually, the component thought to be responsible for the observed drug-induced liver injury was able to be identified. Lymphocyte migration inhibition testing indicated that the tuber of the perennial herbage Pinellia ternate was the causative agent.
Aiba
Tsuneo
T
Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.
Takahashi
Toru
T
Suzuki
Kenji
K
Okoshi
Shogo
S
Nomoto
Minoru
M
Uno
Katsuji
K
Aoyagi
Yutaka
Y
D000208:Acute Disease; D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D001663:Bilirubin / Q000097:blood; D002464:Cell Migration Inhibition; D002465:Cell Movement / Q000187:drug effects; D056486:Chemical and Drug Induced Liver Injury / Q000201:enzymology / Q000209:etiology* / Q000276:immunology / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000009:adverse effects* / Q000737:chemistry; D005303:Fertility Agents, Male / Q000009:adverse effects* / Q000737:chemistry; D006801:Humans; D007565:Jaundice / Q000139:chemically induced* / Q000201:enzymology / Q000276:immunology / Q000378:metabolism; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology; D008297:Male; D030021:Pinellia / Q000009:adverse effects; D035281:Plant Tubers / Q000009:adverse effects
D004365:Drugs, Chinese Herbal; D005303:Fertility Agents, Male; C080903:sairei-to; D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D001663:Bilirubin