Cell lineage regulators in B and T cell development.
This special issue highlights a pivotal set of regulatory molecules that have emerged as central controllers of cell-type identity in the immune system. Each in its own way has been considered as a kind of 'master' regulator of a particular cell fate choice, but the actual modes of action of these factors vary widely. The comparison among them sheds light on the different ways that an essential regulatory input can affect cellular identity.
Rothenberg
Ellen V
EV
Division of Biology, 156-29, California Institute of Technology, Pasadena, California 91125, USA. evroth@its.caltech.edu
D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D002454:Cell Differentiation; D019070:Cell Lineage / Q000502:physiology*; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology / Q000378:metabolism