title: What symptom and functional dimensions can be predictors for global ratings of overall quality of life in lung cancer patients?
abstract: OBJECTIVE
  This study explores what dimensions of a health-related quality of life (HRQOL) questionnaire predict global ratings of overall quality of life (QOL) in lung cancer patients in assessments by patients and significant others, respectively.
  
  
  METHODS
  The analyses were based on dyadic assessments from lung cancer patients and their significant others. A subset of scales and items from the Swedish version of the European Organization for Research and Treatment of Cancer (EORTC) QLQ C30 and the lung-cancer-specific module, LC-13, was selected. Using multiple regression procedures, the relative importance of different symptoms and of functional impairments in predicting overall QOL was examined.
  
  
  RESULTS
  The multiple regressions revealed that emotional functioning and fatigue were the only significant predictors of overall QOL for both the patients and the significant others' assessments. In addition, physical functioning was found to be another predictor in the significant others' assessments.
  
  
  CONCLUSIONS
  The results emphasize that it is essential to consider both emotional functioning and fatigue as important areas for overall QOL in lung cancer patients.
authors: Division of Nursing, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, 23300, 141 83 Huddinge, Sweden. ulrika.ostlund@ki.se
authors: Ulrika
authors: U
authors: Ostlund
authors: Agneta
authors: A
authors: Wennman-Larsen
authors: Petter
authors: P
authors: Gustavsson
authors: Yvonne
authors: Y
authors: Wengström
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008175:Lung Neoplasms / Q000523:psychology*; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D013548:Sweden