Efficacy of 25% diluted fluticasone propionate 0.05% cream as wet-wrap treatment in cutaneous mastocytosis.
BACKGROUND
Mastocytosis is a disorder that can be subdivided into two forms: cutaneous and systemic. Patients with cutaneous mastocytosis only may suffer from cosmetic problems. Topical steroid application has been shown to be effective in cases of limited skin lesions.


METHODS
A case-controlled pilot study was conducted during a 6-weeks treatment using diluted 25% fluticasone propionate 0.05% cream under wet-wrap occlusion in 5 adults and 6 children. Improvement was measured up to the 24th week after treatment using the SCORMA Index.


RESULTS
The results of this pilot study showed a partial but clear cosmetic improvement in 9 of the 11 patients. The mean SCORMA Index decreased after treatment from 38 to 26.


CONCLUSIONS
25% dilution of fluticasone propionate 0.05% cream under wet-wrap occlusion is an alternative treatment modality for alleviating the symptoms of cutaneous mastocytosis, but the improvement may be moderate and fall short of the patient's expectations.
Heide
Rogier
R
Department of Dermatology, MCA, Alkmaar, The Netherlands.
de Waard-van der Spek
Flora B
FB
den Hollander
Jan C
JC
Tank
Bhupendra
B
Oranje
Arnold P
AP
D000287:Administration, Topical; D000328:Adult; D000730:Androstadienes / Q000008:administration & dosage*; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D016022:Case-Control Studies; D002648:Child; D004643:Emollients; D000068298:Fluticasone; D006801:Humans; D034701:Mastocytosis, Cutaneous / Q000188:drug therapy*; D009779:Occlusive Dressings; D010865:Pilot Projects; D016896:Treatment Outcome
D000730:Androstadienes; D000893:Anti-Inflammatory Agents; D004643:Emollients; D000068298:Fluticasone