title: Cold heparinized lactated Ringers with procaine (HeLP) preservation fluid in 266 living donor kidney transplantations.
abstract: Since the 1960s simple inexpensive cold lactated Ringers with additives has been used for short-term cold preservation of kidneys from living donors. We performed 266 living donor kidney transplantations from January 22, 2003 to October 30, 2006. Donor allografts were recovered laparoscopically and flushed with cold heparin, lactated Ringer's and procaine (HeLP) solution. Warm and cold ischemic times were typically <45 min and <90 min, respectively. The mean follow up was 21.6+/-12.2 months. There was no delayed graft function. Actuarial 1-year patient and graft survival were 98.6% and 98.1%, respectively. The creatinine at 1 year was 1.46+/-0.51 mg/dL. The cumulative incidences of acute cellular rejection at 6, 12, 18, and 24 months were 3.0%, 7.1%, 10.2%, and 11.7%. There were no identifiable side effects attributed to the HeLP solution. This study documents the effectiveness of cold HeLP as a flushing and short-term preservation fluid for living donor kidney transplantation with excellent results and significant cost benefit because of its low cost.
authors: The Thomas E. Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA. tanhp@upmc.edu
authors: Henkie P
authors: HP
authors: Tan
authors: Dinesh
authors: D
authors: Vyas
authors: Amit
authors: A
authors: Basu
authors: Parmjeet
authors: P
authors: Randhawa
authors: Nirav
authors: N
authors: Shah
authors: Joseph
authors: J
authors: Donaldson
authors: Amadeo
authors: A
authors: Marcos
authors: Richard L
authors: RL
authors: Simmons
authors: Thomas E
authors: TE
authors: Starzl
authors: Ron
authors: R
authors: Shapiro
mesh_terms: D001215:Asparaginase; D003080:Cold Temperature; D005500:Follow-Up Studies; D006493:Heparin / Q000494:pharmacology*; D006801:Humans; D007552:Isotonic Solutions / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects; D016030:Kidney Transplantation / Q000379:methods*; D019520:Living Donors; D009926:Organ Preservation / Q000379:methods*; D011343:Procaine / Q000494:pharmacology*; D000077325:Ringer's Lactate
chemical_list: D007552:Isotonic Solutions; D000077325:Ringer's Lactate; D011343:Procaine; D006493:Heparin; D001215:Asparaginase