title: The push and pull of the bacterial cytoskeleton.
abstract: A crucial function for eukaryotic cytoskeletal filaments is to organize the intracellular space: facilitate communication across the cell and enable the active transport of cellular components. It was assumed for many years that the small size of the bacterial cell eliminates the need for a cytoskeleton, because simple diffusion of proteins is rapid over micron-scale distances. However, in the last decade, cytoskeletal proteins have indeed been found to exist in bacteria where they have an important role in organizing the bacterial cell. Here, we review the progress that has been made towards understanding the mechanisms by which bacterial cytoskeletal proteins influence cellular organization. These discoveries have advanced our understanding of bacterial physiology and provided insight into the evolution of the eukaryotic cytoskeleton.
authors: Department of Biochemistry, Beckman Center, Stanford University, Stanford, CA 94305, USA.
authors: Natalie A
authors: NA
authors: Dye
authors: Lucy
authors: L
authors: Shapiro
mesh_terms: D001419:Bacteria; D001426:Bacterial Proteins / Q000502:physiology; D003598:Cytoskeletal Proteins / Q000502:physiology*; D029968:Escherichia coli Proteins / Q000502:physiology
chemical_list: D001426:Bacterial Proteins; D003598:Cytoskeletal Proteins; D029968:Escherichia coli Proteins; C071525:FtsZ protein, Bacteria; C062061:MreC protein, Bacteria; C078473:MreB protein, E coli