title: (-)-Menthol inhibits WEHI-3 leukemia cells in vitro and in vivo.
abstract: (-)-Menthol ([1-alpha]-5-methyl-2-[1-methylethyl]-cyclohexanol), is a widely used flavoring ingredient in mouthwash, foods, toothpaste and cigarettes. The studies reported here revealed that (-)-menthol induced cytotoxicity against murine leukemia WEHI-3 cells in vitro in a dose-dependent manner. The effects of (-)-menthol on WEHI-3 cells in vivo (BALBIc mice) were also examined, and it was observed that the Mac-3 and CD11b markers were decreased, indicating inhibition of differentiation of the precursor of macrophage and granulocyte. The weights of liver and spleen samples from mice treated with (-)-menthol were found to be decreased compared to untreated animals.
authors: Department of Clinical Pathology, Cheng Hsin Rehabilitation Medical Center, Taipei.
authors: Hsu-Fung
authors: HF
authors: Lu
authors: Jia-You
authors: JY
authors: Liu
authors: Shu-Ching
authors: SC
authors: Hsueh
authors: Yi-Yuan
authors: YY
authors: Yang
authors: Jai-Sing
authors: JS
authors: Yang
authors: Tzu-Wei
authors: TW
authors: Tan
authors: Lai-Fong
authors: LF
authors: Kok
authors: Chi-Cheng
authors: CC
authors: Lu
authors: Sheng-Huei
authors: SH
authors: Lan
authors: Shan-Ying
authors: SY
authors: Wu
authors: Shiu-Shin
authors: SS
authors: Liao
authors: Siu-Wan
authors: SW
authors: Ip
authors: Jing-Gung
authors: JG
authors: Chung
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D007942:Leukemia, Experimental / Q000188:drug therapy* / Q000473:pathology*; D015479:Leukemia, Myelomonocytic, Acute / Q000097:blood / Q000188:drug therapy / Q000473:pathology; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008610:Menthol / Q000097:blood / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D051379:Mice; D008807:Mice, Inbred BALB C; D013154:Spleen / Q000187:drug effects / Q000473:pathology
chemical_list: D008610:Menthol