Hsp60 and Hspl0 as antitumor molecular agents.
The molecular chaperones Hsp60 and Hsp10 are, according to recent reports, involved in cancer development and progression. We, for instance, have found that their expression varies with distinctive patterns in different malignancies: they are overexpressed in colorectal, exocervical and prostate carcinogenesis, and colorectal cancer progression, but they are downregulated during bronchial carcinogenesis. There is also evidence showing that Hsp60 and Hsp10 can be used as therapeutic agents, for example in rheumatoid arthritis. In view of these findings we want now to call attention to the potential of Hsp60 and Hsp10 in cancer therapy.
Cappello
Francesco
F
Department of Experimental Medicine, University of Palermo, Palermo, Italy. francapp@hotmail.com
Czarnecka
Anna M
AM
La Rocca
Giampiero
G
Di Stefano
Antonino
A
Zummo
Giovanni
G
Macario
Alberto J L
AJ
D018835:Chaperonin 10 / Q000627:therapeutic use*; D018834:Chaperonin 60 / Q000627:therapeutic use*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*
D018835:Chaperonin 10; D018834:Chaperonin 60