A novel method using cyanobacteria for ecotoxicity test of veterinary antimicrobial agents.
The effect of antimicrobial agents for veterinary use on the growth of cyanobacteria was investigated by measuring minimum inhibitory concentration, medium effective concentration (EC50), and no-observed-effect concentration of seven antimicrobial agents for eight cyanobacteria. The results demonstrated that the seven antimicrobial agents, even at low concentrations, inhibited the growth of cyanobacteria. Microcystis aeruginosa and Synechococcus sp. had the highest sensitivity to the antimicrobial agents used in the present study. It is considered that the utilization of cyanobacteria would enable easy and highly sensitive assessment of the toxicity of such chemicals as antimicrobial agents. We suggest that cyanobacteria be used for ecotoxicity test in addition to the hitherto established method that uses green algae.
Ando
Tomonori
T
Laboratory of Environmental Biotechnology, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka Suita, Osaka 565-0871, Japan.
Nagase
Hiroyasu
H
Eguchi
Kaoru
K
Hirooka
Takashi
T
Nakamura
Takanori
T
Miyamoto
Kazuhisa
K
Hirata
Kazumasa
K
D000890:Anti-Infective Agents / Q000633:toxicity*; D000458:Cyanobacteria / Q000187:drug effects* / Q000254:growth & development; D004305:Dose-Response Relationship, Drug; D008826:Microbial Sensitivity Tests; D019055:No-Observed-Adverse-Effect Level; D018675:Toxicity Tests / Q000379:methods*; D019155:Veterinary Drugs / Q000633:toxicity*
D000890:Anti-Infective Agents; D019155:Veterinary Drugs