Tubuloglomerular feedback responses of the downstream efferent resistance: unmasking a role for adenosine?
This Commentary aims to integrate or interrelate the available in vivo data with the in vitro study by Ren and co-workers, which comes to the somewhat surprising conclusion that tubuloglomerular feedback activation vasodilates the efferent arteriole by an adenosine-dependent mechanism.
Blantz
R C
RC
Department of Medicine, University of California, San Diego, California 92161, USA. rblantz@ucsd.edu
Vallon
V
V
D000241:Adenosine / Q000502:physiology*; D000818:Animals; D001160:Arterioles / Q000502:physiology*; D005246:Feedback; D007678:Kidney Glomerulus / Q000098:blood supply / Q000502:physiology*; D007684:Kidney Tubules / Q000098:blood supply*; D008954:Models, Biological; D011817:Rabbits; D012079:Renal Circulation
D000241:Adenosine