title: [An ultrasonic scoring system for assessing the severity of hepatic fibrosis in patients with chronic hepatitis B].
abstract: OBJECTIVE
  To discuss the diagnostic value of an ultrasonic assessing system for detecting the severity of hepatic fibrosis in patients with chronic hepatitis B (CHB).
  
  
  METHODS
  Ultrasonographic variables were analyzed in 110 CHB patients. An ultrasonic semi-quantitative scoring system using seven ultrasonic morphologic parameters, a Fisher discriminating function and three quantitative ultrasonic parameters was developed. The performance of these methods was also studied and compared.
  
  
  RESULTS
  The areas under the curve of the scoring system for different liver fibrosis stages were >or= S2: 0.946, >or= S3: 0.914, and S4: 0.915. The total score was well correlated with the histological stage of fibrosis (r=0.824, P < 0.001). There was a significant difference between the stages of fibrosis. The accuracy of the Fisher discriminating function for identifying three study endpoints was 76.5%, 78.2% and 67.3%. Combining the ultrasonic scoring system and the discriminating function, the specificity was 85%-90% and the accuracy was 77%-84%.
  
  
  CONCLUSIONS
  Our ultrasonic semi-quantitative scoring system is a noninvasive method for quantitating liver fibrosis. If it is used together with a discriminating function, the accuracy of diagnosing liver fibrosis can be significantly increased.
authors: Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
authors: Wen-sheng
authors: WS
authors: Zhang
authors: Bo-en
authors: BE
authors: Wang
authors: Ji-dong
authors: JD
authors: Jia
authors: Xiao-juan
authors: XJ
authors: Ou
authors: Tai-ling
authors: TL
authors: Wang
authors: Lin-xue
authors: LX
authors: Qian
authors: Fu-kui
authors: FK
authors: Zhang
authors: Hong
authors: H
authors: Ma
authors: Hong
authors: H
authors: You
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D019694:Hepatitis B, Chronic / Q000000981:diagnostic imaging*; D006801:Humans; D008103:Liver Cirrhosis / Q000000981:diagnostic imaging* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D018615:Ultrasonography, Doppler, Color; D055815:Young Adult