Sutureless vascular anastomoses by N-butyl-2 cyanoacrylate adhesive: an experimental animal study.
BACKGROUND
The purpose of this animal study was to find out whether sutureless anastomoses using N-butyl-2-cyanoacrylate were effective in the suppression of neointimal hyperplasia or not.


METHODS
Ten male adult mongrel dogs were used in this animal study. The animals were randomly divided into a control group (n = 5) and a study group (n = 5). The study group underwent sutureless anastomoses using N-buthyl-2-cyanoacrylate adhesive. Infrarenal aortoaortic graft was interposed using polytetrafluoroethylene.


RESULTS
In the study group, the mean intimal thickness at the proximal anastomosis was 27.4 +/- 1.94 microm and 27.4 +/- 1.51 microm at the distal anastomosis. In the control group, the mean intimal thickness was 138.4 +/- 5.02 mum at the proximal anastomosis and 67.6 +/- 6.42 microm at the distal anastomosis. Intimal thickness at the proximal and distal anastomoses in the control group was significantly (p < 0.001) greater than in the study group. Also, perianastomotic inflammation was more obvious in the control group compared to the study group (p < 0.01).


CONCLUSIONS
Sutureless anastomoses using with N-butyl-2-cyanoacrylate adhesive might be a good alternative to conventional suture technique.
Saba
D
D
Department of Cardiovascular Surgery, Faculty of Medicine, Uludag University, Bursa, Turkey. davids@uludag.edu.tr
Yilmaz
M
M
Yavuz
H
H
Noyan
S
S
Avci
B
B
Ercan
A
A
Ozkan
H
H
Cengiz
M
M
D000714:Anastomosis, Surgical / Q000379:methods*; D000818:Animals; D001011:Aorta / Q000473:pathology / Q000601:surgery*; D004285:Dogs; D004659:Enbucrilate / Q000031:analogs & derivatives* / Q000494:pharmacology; D006965:Hyperplasia; D008297:Male; D023421:Models, Animal; D013537:Sutures; D014014:Tissue Adhesives / Q000494:pharmacology*; D017539:Tunica Intima / Q000473:pathology; D014656:Vascular Surgical Procedures / Q000379:methods*
D014014:Tissue Adhesives; D004659:Enbucrilate