The etiologic distribution of thrombophilic factors in chronic portal vein thrombosis.
OBJECTIVE
We aimed to prospectively investigate the full etiologic contributors to portal vein thrombosis.


BACKGROUND
Portal vein thrombosis in the absence of liver disease is a rare cause of portal hypertension with a different clinical course and management strategy. The etiologic distribution of this interesting clinical picture is important as far as diagnostic and management issues are concerned.


METHODS
After the application of exclusion criteria, 59 patients were included in the study who had normal liver functions, normal liver histology and studied the thrombophilia factors of both acquired factors and congenital factors like protein C, protein S, antithrombin levels with the mutations.


RESULTS
In all, 23.7% of the patients were found to have acquired thrombophilia factors like myeloproliferative disorders and cyst hydatid disease, whereas 22.1% of the patient population was found to harbor no identifiable cause of thrombophilia, which we termed as idiopathic. One or more causes of thrombophilia were identified in 46 patients. There were 27 patients with protein C deficiency, 18 patients with protein S deficiency. The antithrombin deficiency was found in 17 patients. The factor V Leiden mutation was found in 7 patients. There was 1 patient with homozygote mutation, whereas the remaining 6 patients were heterozygotes. There were 3 patients with prothrombin mutation who were heterozygote for this mutation.


CONCLUSIONS
Complete investigation of thrombophilia is crucial to delineate the outline of thrombophilic risk factors to estimate the rethrombosis risk and for further management concerns.
Harmanci
Ozgur
O
Department of Gastroenterology, Hacettepe University Faculty of Medicine, 06100 Sihhiye, Ankara, Turkey. ozgurmd@hacettepe.edu.tr
Ersoy
Osman
O
Gurgey
Aytemiz
A
Buyukasik
Yahya
Y
Gedikoglu
Gokhan
G
Balkanci
Ferhun
F
Sivri
Bulent
B
Bayraktar
Yusuf
Y
D000328:Adult; D000990:Antithrombin III / Q000032:analysis; D002908:Chronic Disease; D005165:Factor V / Q000032:analysis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011169:Portal Vein; D011446:Prospective Studies; D011486:Protein C / Q000032:analysis; D017293:Protein S / Q000032:analysis; D011516:Prothrombin / Q000032:analysis; D012307:Risk Factors; D019851:Thrombophilia / Q000150:complications*; D020246:Venous Thrombosis / Q000209:etiology*
D011486:Protein C; D017293:Protein S; D000990:Antithrombin III; D005165:Factor V; D011516:Prothrombin