title: Focal epileptiform activity described by a large computerised EEG database.
abstract: OBJECTIVE
  To study the age-related topographical tendency of expressing epileptiform activity, and the effect of focal epileptiform activity (FEA) on the general cortical brain activity.
  
  
  METHODS
  1647 consecutive routine EEGs containing FEA were visually assessed for FEA location and asymmetry. Background activity was compared with that in normal EEGs from 3268 drug-free outpatient controls.
  
  
  RESULTS
  FEA localisation was age-related (p<0.0005) except for the temporal region (p=0.22) where FEA was found equally often in the young and the old. The left hemisphere was more prone to FEA (p=0.018). The left-right asymmetry varied by age (p=0.013). FEA asymmetry occurred most frequently in EEGs from patients older than 80 years, and least frequent in the age-group 20-39 years. FEA was associated with lower alpha rhythm (AR) frequencies (p=0.0041) and higher AR amplitudes (p=0.0023), as well as higher general background activity (GBA) amplitude (p<0.0005), while GBA frequencies were the same (p=0.96).
  
  
  CONCLUSIONS
  Topographical localisation of FEA was age-dependent. There was an overall left dominance, but the side asymmetry was modest and varied by age. FEA was associated with changes in AR and GBA.
  
  
  CONCLUSIONS
  The results demonstrate that FEA is associated with cerebral cortical dysfunction also distant from the epileptic focus.
authors: Section of Clinical Neurophysiology, Department of Neurology, Haukeland University Hospital, Bergen, Norway. harald.aurlien@helse-bergen.no
authors: H
authors: H
authors: Aurlien
authors: J H
authors: JH
authors: Aarseth
authors: I O
authors: IO
authors: Gjerde
authors: B
authors: B
authors: Karlsen
authors: H
authors: H
authors: Skeidsvoll
authors: N E
authors: NE
authors: Gilhus
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000503:physiopathology*; D016208:Databases, Factual / Q000706:statistics & numerical data*; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D004569:Electroencephalography; D004827:Epilepsy / Q000453:epidemiology / Q000473:pathology / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged