title: Invertebrate lamins.
abstract: Lamins are the main component of the nuclear lamina and considered to be the ancestors of all intermediate filament proteins. They are localized mainly at the nuclear periphery where they form protein complexes with integral proteins of the nuclear inner membrane, transcriptional regulators, histones and chromatin modifiers. Studying lamins in invertebrate species has unique advantages including the smaller number of lamin genes in the invertebrate genomes and powerful genetic analyses in Caenorhabditis elegans and Drosophila melanogaster. These simpler nuclear lamina systems allow direct analyses of their structure and functions. Here we give an overview of recent advances in the field of invertebrate nuclear lamins with special emphasis on their evolution, assembly and functions.
authors: Department of Genetics, The Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.
authors: Shai
authors: S
authors: Melcer
authors: Yosef
authors: Y
authors: Gruenbaum
authors: Georg
authors: G
authors: Krohne
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics / Q000378:metabolism / Q000648:ultrastructure; D004331:Drosophila melanogaster / Q000235:genetics / Q000378:metabolism / Q000648:ultrastructure; D019143:Evolution, Molecular; D007448:Invertebrates / Q000235:genetics* / Q000378:metabolism* / Q000648:ultrastructure; D034882:Lamins / Q000235:genetics* / Q000378:metabolism*; D034881:Nuclear Lamina / Q000235:genetics* / Q000378:metabolism* / Q000648:ultrastructure; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism; D010802:Phylogeny; D017434:Protein Structure, Tertiary / Q000502:physiology
chemical_list: D034882:Lamins; D009687:Nuclear Proteins