title: Psychiatric morbidity and X-chromosomal origin in a Klinefelter sample.
abstract: The presence of an additional X-chromosome in Klinefelter patients provides an opportunity to study the influence of this chromosome on psychiatric disorders. Previous studies have reported an excess of Klinefelter patients in psychiatric patient groups. We report an increased prevalence of psychiatric disorders including psychotic disorders in a sample of Klinefelter patients but could not find evidence of an effect of the parental origin of the extra X-chromosome on the psychiatric phenotype. Nevertheless, these findings provide further support for the role of the X-chromosome in the susceptibility to psychiatric disorders in general and psychotic disorders in particular.
authors: Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, Utrecht, The Netherlands. mboks@umcutrecht.nl
authors: Marco P M
authors: MP
authors: Boks
authors: Marjolein H T
authors: MH
authors: de Vette
authors: Iris E
authors: IE
authors: Sommer
authors: Sophie
authors: S
authors: van Rijn
authors: Jacques C
authors: JC
authors: Giltay
authors: Hanna
authors: H
authors: Swaab
authors: René S
authors: RS
authors: Kahn
mesh_terms: D000328:Adult; D041321:Chromosomes, Human, X / Q000235:genetics*; D015897:Comorbidity; D003430:Cross-Sectional Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D007713:Klinefelter Syndrome / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics* / Q000523:psychology; D008297:Male; D001523:Mental Disorders / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics*; D008875:Middle Aged; D010641:Phenotype; D011618:Psychotic Disorders / Q000175:diagnosis / Q000235:genetics / Q000523:psychology; D012559:Schizophrenia / Q000175:diagnosis / Q000235:genetics; D012565:Schizophrenic Psychology; D012729:Sex Chromosome Aberrations