title: Synthesis and SAR of aminopyrimidines as novel c-Jun N-terminal kinase (JNK) inhibitors.
abstract: The development of a series of novel aminopyrimidines as inhibitors of c-Jun N-terminal kinases is described. The synthesis, in vitro inhibitory values for JNK1, JNK2 and CDK2, and the in vitro inhibitory value for a c-Jun cellular assay are discussed.
authors: UCB, Granta Park, Great Abington, Cambridge CB21 6GS, UK.
authors: Mahbub
authors: M
authors: Alam
authors: Rebekah E
authors: RE
authors: Beevers
authors: Tom
authors: T
authors: Ceska
authors: Richard J
authors: RJ
authors: Davenport
authors: Karen M
authors: KM
authors: Dickson
authors: Mara
authors: M
authors: Fortunato
authors: Lewis
authors: L
authors: Gowers
authors: Alan F
authors: AF
authors: Haughan
authors: Lynwen A
authors: LA
authors: James
authors: Mark W
authors: MW
authors: Jones
authors: Natasha
authors: N
authors: Kinsella
authors: Christopher
authors: C
authors: Lowe
authors: Johannes W G
authors: JW
authors: Meissner
authors: Anne-Lise
authors: AL
authors: Nicolas
authors: Benjamin G
authors: BG
authors: Perry
authors: David J
authors: DJ
authors: Phillips
authors: William R
authors: WR
authors: Pitt
authors: Adam
authors: A
authors: Platt
authors: Andrew J
authors: AJ
authors: Ratcliffe
authors: Andrew
authors: A
authors: Sharpe
authors: Laura J
authors: LJ
authors: Tait
mesh_terms: D051357:Cyclin-Dependent Kinase 2 / Q000037:antagonists & inhibitors; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology*; D048031:JNK Mitogen-Activated Protein Kinases / Q000037:antagonists & inhibitors*; D048055:Mitogen-Activated Protein Kinase 8 / Q000037:antagonists & inhibitors; D048056:Mitogen-Activated Protein Kinase 9 / Q000037:antagonists & inhibitors; D008956:Models, Chemical; D013329:Structure-Activity Relationship
chemical_list: D004791:Enzyme Inhibitors; D048056:Mitogen-Activated Protein Kinase 9; D051357:Cyclin-Dependent Kinase 2; D048031:JNK Mitogen-Activated Protein Kinases; D048055:Mitogen-Activated Protein Kinase 8