The influence of genetics on nicotine dependence and the role of pharmacogenetics in treating the smoking habit.
Despite the considerable efforts made in the fight against smoking in the last decades, there are still substantial numbers of people who, in full knowledge of the health hazards, begin smoking or continue smoking. Recent studies have focused on the genetic bases of the nicotine addiction. Various genetic polymorphisms have been associated with smoking. However, environmental factors have also been shown to play a role. In this review, we present some of the principal data collected in genetic studies of smoking behavior. The results obtained through this line of research will eventually aid clinicians in individualizing the type, dosage and duration of treatment for patients with nicotine dependence in accordance with the genotype of each smoker, thereby maximizing the efficacy of the proposed treatment regimen.
Chatkin
José Miguel
JM
Faculdade de Medicina, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS, Brasil. jmchatki@pucrs.br <jmchatki@pucrs.br>
D020022:Genetic Predisposition to Disease; D006801:Humans; D010597:Pharmacogenetics; D011110:Polymorphism, Genetic; D012907:Smoking / Q000188:drug therapy / Q000235:genetics*; D014029:Tobacco Use Disorder / Q000188:drug therapy / Q000235:genetics*