title: Preparation of poly(MAA-g-EG) hydrogel nanoparticles by a thermally-initiated free radical dispersion polymerization.
abstract: Poly(methacrylic acid-grafted-poly(ethylene glycol)) (P(MAA-g-EG)) hydrogel nanoparticles (HNPs) were prepared by a thermally-initiated free radical dispersion polymerization method. The effects of various reaction parameters on the preparation of HNPs were investigated, including the quantity of monomer, temperature, initiator dosage, crosslinker dosage, and co-stabilizer concentration. The reaction temperature at 75 degrees C was found to be suitable for preparing stable and small P(MAA-g-EG) HNPs. By adding a little amount of polyvinyl alcohol in the reaction media, P(MAA-g-EG) HNPs with narrow size distribution could be obtained. The effects of pH and the crosslinker dosage on the equilibrium swelling behavior of P(MAA-g-EG) HNPs were also studied. The P(MAA-g-EG) HNPs perform pH-responsive swelling behavior, which is strongly influenced by the crosslinker dosage.
authors: Department of Polymer Science and Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, P. R. China.
authors: Liandong
authors: L
authors: Deng
authors: Xiaohua
authors: X
authors: He
authors: Aigui
authors: A
authors: Li
authors: Qiuxia
authors: Q
authors: Yang
authors: Anjie
authors: A
authors: Dong
mesh_terms: D002021:Buffers; D003432:Cross-Linking Reagents / Q000737:chemistry*; D005609:Free Radicals / Q000737:chemistry; D005612:Freeze Drying; D006358:Hot Temperature; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles / Q000032:analysis / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D010710:Phosphates / Q000737:chemistry; D010772:Phosphotungstic Acid / Q000494:pharmacology; D011092:Polyethylene Glycols / Q000737:chemistry*; D011109:Polymethacrylic Acids / Q000737:chemistry*; D011142:Polyvinyl Alcohol / Q000737:chemistry; D012972:Sodium Hydroxide / Q000737:chemistry; D013010:Sonication; D017550:Spectroscopy, Fourier Transform Infrared; D014867:Water / Q000737:chemistry
chemical_list: D002021:Buffers; D003432:Cross-Linking Reagents; D005609:Free Radicals; D010710:Phosphates; D011109:Polymethacrylic Acids; D014867:Water; D010772:Phosphotungstic Acid; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D011092:Polyethylene Glycols; D012972:Sodium Hydroxide; D011142:Polyvinyl Alcohol