Consideration of use of phenothiazines in particular trifluorperazine for epidermal growth factor receptor associated cancers.
Papers from a generation ago suggested that phenothiazines--in particular trifluorperazine (Stelazine) a medicinal approved by the FDA and still commonly used for schizophrenia--downregulate the epidermal growth factor receptor. As numerous cancers--e.g., colon cancer, breast cancer, pancreatic cancer and glioblastoma--are dependent on signaling via this receptor, we here suggest that phenothiazines such as trifluorperazine be considered for use in epidermal growth factor receptor associated cancers.
Kast
Richard E
RE
Department of Psychiatry, College of Medicine, University of Vermont, 2 Church Street, Burlington, VT 05401, United States.
Altschuler
Eric Lewin
EL
D066246:ErbB Receptors / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism*; D010640:Phenothiazines / Q000008:administration & dosage; D014268:Trifluoperazine / Q000008:administration & dosage*
D010640:Phenothiazines; D014268:Trifluoperazine; D066246:ErbB Receptors