[The importance of choline and different serum parameters for the course of the anorexia nervosa].
Malnutrition in anorexia nervosa was simulated in an animal starvation study. Female rats aged 11 to 13 weeks received a hypocaloric standard diet or a hypocaloric choline reduced diet. Weight reduction lasted for 12 to 20 weeks and was between 30 % to 40 % of initial weight. Several animals were refed after weight reduction up to 6 to 12 weeks with a standard or a choline enriched diet ad libitum. Serum parameters and membrane fluidity of the CNS were measured after weight reduction or after refeeding. Weight reduction leads to a significant decrease of serum protein, triglycerides (Z = -3.53 resp. -3.42; p < 0.001) and an increase of membrane fluidity in the CNS (Z = -2.83; p < 0.001). Long-term diet with marked weight reduction and following refeeding causes a catabole metabolic situation with significant increase of urea/creatinine-ratio. Choline enriched refeeding after diet results in normalization of serum parameters and membrane fluidity of the CNS. Choline enrichment leads to a significant increase of serum protein (Z = -2.03; p < 0.01). Besides we found a negative correlation between serum protein and urea/creatinine-ratio (r (S) = -0.47; p < 0.001; n = 64). This is possibly caused by a reduced protein catabolism or an increased protein anabolism. Furthermore membrane fluidity in the CNS correlates with serum protein (r (S) = 0.65; p < 0.001; n = 41) and with serum creatinine levels (r (S) = 0.58; p < 0.001; n = 42). We conclude that these serum parameters are potential predictors for cell function in the starved brain and consequently for the course of anorexia nervosa. We furthermore hypothesize that choline enriched nutrition after starvation improves the stabilization of cerebral membranes and the metabolic situation in anorexia nervosa.
Wöckel
L
L
Klinik für Psychiatrie und Psychotherapie des Kindes- und Jugendalters, Universität Frankfurt am Main, 60528 Frankfurt/Main. woeckel@em.uni-frankfurt.de
Bertsch
T
T
Koch
S
S
Achtnichts
L
L
Holtmann
M
M
Gretz
N
N
Schmidt
M H
MH
Poustka
F
F
D000818:Animals; D000856:Anorexia Nervosa / Q000097:blood* / Q000188:drug therapy / Q000503:physiopathology; D001798:Blood Proteins / Q000378:metabolism; D002794:Choline / Q000097:blood / Q000502:physiology* / Q000627:therapeutic use; D003404:Creatinine / Q000097:blood; D004032:Diet; D002149:Energy Intake / Q000502:physiology; D005260:Female; D008560:Membrane Fluidity / Q000187:drug effects / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D014508:Urea / Q000097:blood; D015431:Weight Loss / Q000502:physiology
D001798:Blood Proteins; D014508:Urea; D003404:Creatinine; D002794:Choline