title: Temperament and response to the Trier Social Stress Test.
abstract: OBJECTIVE
  The personality characteristics behavioural inhibition and neuroticism have been associated with mood and anxiety disorders and, in some studies, hypothalamic-pituitary-adrenal (HPA) axis hyperactivity. We recently reported that low levels of Novelty Seeking were associated with elevated plasma cortisol responses to the dexamethasone/corticotropin-releasing hormone (Dex/CRH) test in healthy adults with no psychiatric disorder. The present study tested the association between temperament and HPA axis function in the same group of subjects using a standardized psychosocial neuroendocrine stress test.
  
  
  METHODS
  Subjects completed diagnostic interviews, questionnaires, and the Trier Social Stress Test (TSST).
  
  
  RESULTS
  Novelty Seeking was inversely associated with plasma cortisol concentrations at baseline and throughout the TSST, but was not related to adrenocorticotropic hormone (ACTH) levels.
  
  
  CONCLUSIONS
  Results of this study extend our previous finding in the Dex/CRH test to a psychosocial stress test. Future investigations are needed to replicate these findings and further elucidate how temperament and personality are linked to HPA function.
authors: Mood Disorders Research Program and Laboratory for Clinical Neuroscience, Butler Hospital, Brown Medical School, Providence, RI 02906, USA. audrey_tyrka@brown.edu
authors: A R
authors: AR
authors: Tyrka
authors: L M
authors: LM
authors: Wier
authors: G M
authors: GM
authors: Anderson
authors: C W
authors: CW
authors: Wilkinson
authors: L H
authors: LH
authors: Price
authors: L L
authors: LL
authors: Carpenter
mesh_terms: D000293:Adolescent; D000324:Adrenocorticotropic Hormone / Q000097:blood; D000328:Adult; D000339:Affect / Q000502:physiology; D001143:Arousal / Q000502:physiology*; D003346:Corticotropin-Releasing Hormone; D003907:Dexamethasone; D005106:Exploratory Behavior / Q000502:physiology; D005260:Female; D040261:Harm Reduction; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D010913:Pituitary-Adrenal System / Q000503:physiopathology; D013315:Stress, Psychological / Q000150:complications* / Q000503:physiopathology; D013694:Temperament / Q000502:physiology*
chemical_list: D003907:Dexamethasone; D000324:Adrenocorticotropic Hormone; D003346:Corticotropin-Releasing Hormone; D006854:Hydrocortisone