[Primary gastric T-cell lymphoma with predominant bone marrow infiltration undergoing aggressive clinical course].
A 63-year-old man complained of high fever, epigastralgia, and severe cytopenia in June, 2005. Upper gastroduodenal endoscopy revealed a gastric tumor in the greater curvature of the body. Biopsy specimens showed the infiltration of medium-sized abnormal cells. Bone marrow biopsy also indicated infiltration of the medium-sized abnormal cells. Immunophenotyping with abnormal cells was positive for CD 3, negative for CD 20 and cytokeratin. Serum investigation showed human T-cell lymphotropic virus-1 (HTLV-1) antibody below 16 fold. The diagnosis was HTLV-1 unassociated primary gastric T-cell lymphoma with bone marrow infiltration. After undergoing oral chemotherapy with VP-16 at 25 mg/day, combination chemotherapy was initiated with vincristine 2 mg/day and dexamethasone 48 mg/day. The man died with the aggressive clinical course after combination chemotherapy.
Kobayashi
Kichinosuke
K
First Dept. of Internal Medicine, Osaka Medical College.
Yokote
Taiji
T
Akioka
Toshikazu
T
Hara
Satoshi
S
Oka
Satoko
S
Hirata
Yuji
Y
Miyoshi
Takuji
T
Tsuji
Motomu
M
Hanafusa
Toshiaki
T
D018951:Antigens, CD20 / Q000032:analysis; D001859:Bone Neoplasms / Q000473:pathology*; D017252:CD3 Complex / Q000032:analysis; D006801:Humans; D016130:Immunophenotyping; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000188:drug therapy / Q000473:pathology*; D016399:Lymphoma, T-Cell / Q000188:drug therapy / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D013274:Stomach Neoplasms / Q000188:drug therapy / Q000473:pathology*
D018951:Antigens, CD20; D017252:CD3 Complex