ISG20, an actor of the innate immune response.
The interferon (IFN) system is a major effector of the innate immunity that allows time for the subsequent establishment of an adaptive immune response against wide-range pathogens. The effectiveness of IFN to control initial infection requires the cooperation between several pathways induced in the target cells. Recent studies that highlight the implication of the 3'-5' exonuclease ISG20 (IFN Stimulated Gene product of 20 kDa) in the host's defenses against pathogens are summarised in this review.
Degols
Genevieve
G
UMR5160 CNRS, EFS, 240 Avenue Emile Jeanbrau, 34094 Montpellier Cedex 5, France.
Eldin
Patrick
P
Mechti
Nadir
N
D000595:Amino Acid Sequence; D000818:Animals; D002460:Cell Line; D005092:Exonucleases / Q000378:metabolism / Q000502:physiology*; D005095:Exoribonucleases; D006801:Humans; D007113:Immunity, Innate; D007249:Inflammation; D007372:Interferons / Q000378:metabolism; D008954:Models, Biological; D008969:Molecular Sequence Data; D012328:RNA Viruses / Q000378:metabolism; D034741:RNA, Small Interfering / Q000378:metabolism; D051193:Toll-Like Receptors / Q000378:metabolism
D034741:RNA, Small Interfering; D051193:Toll-Like Receptors; D007372:Interferons; D005092:Exonucleases; D005095:Exoribonucleases; C112346:ISG20 protein, human