2-Aryl-2-hydroxyethylamine substituted 4-oxo-4,7-dihydrothieno[2,3-b]pyridines as broad-spectrum inhibitors of human herpesvirus polymerases.
A novel series of 2-aryl-2-hydroxyethylamine substituted 4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxamides have been identified as potent antivirals against human herpesviruses. These compounds demonstrate broad-spectrum inhibition of the herpesvirus polymerases HCMV, HSV-1, EBV, and VZV with high specificity compared to human DNA polymerases.
Schnute
Mark E
ME
Global Research and Development, Pfizer Inc., 700 Chesterfield Parkway West, St. Louis, MO 63017, USA. mark.e.schnute@pfizer.com
Anderson
David J
DJ
Brideau
Roger J
RJ
Ciske
Fred L
FL
Collier
Sarah A
SA
Cudahy
Michele M
MM
Eggen
MariJean
M
Genin
Michael J
MJ
Hopkins
Todd A
TA
Judge
Thomas M
TM
Kim
Euibong J
EJ
Knechtel
Mary L
ML
Nair
Sajiv K
SK
Nieman
James A
JA
Oien
Nancee L
NL
Scott
Allen
A
Tanis
Steven P
SP
Vaillancourt
Valerie A
VA
Wathen
Michael W
MW
Wieber
Janet L
JL
D000998:Antiviral Agents / Q000138:chemical synthesis / Q000494:pharmacology* / Q000627:therapeutic use; D001667:Binding, Competitive; D003587:Cytomegalovirus / Q000187:drug effects*; D004259:DNA-Directed DNA Polymerase; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology* / Q000627:therapeutic use; D005021:Ethylamines / Q000138:chemical synthesis / Q000494:pharmacology*; D005090:Exodeoxyribonucleases / Q000037:antagonists & inhibitors*; D006562:Herpes Zoster / Q000188:drug therapy; D006564:Herpesviridae / Q000187:drug effects* / Q000201:enzymology; D018259:Herpesvirus 1, Human / Q000187:drug effects*; D004854:Herpesvirus 4, Human / Q000187:drug effects*; D006801:Humans; D008956:Models, Chemical; D019384:Nucleic Acid Synthesis Inhibitors; D011725:Pyridines / Q000138:chemical synthesis / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014764:Viral Proteins / Q000037:antagonists & inhibitors*
D000998:Antiviral Agents; D004791:Enzyme Inhibitors; D005021:Ethylamines; D019384:Nucleic Acid Synthesis Inhibitors; D011725:Pyridines; D014764:Viral Proteins; D004259:DNA-Directed DNA Polymerase; D005090:Exodeoxyribonucleases; C043417:DNA polymerase, Simplexvirus