title: Analyses of the 1957 (Asian) influenza pandemic in the United Kingdom and the impact of school closures.
abstract: Many countries plan to close schools during a future influenza pandemic, although the potential impact is poorly understood. We apply a model of the transmission dynamics of pandemic influenza to consultation, serological and clinical data from the United Kingdom from the 1957 (Asian) influenza pandemic, to estimate the basic reproduction number (R0), the proportion of infected individuals who experience clinical symptoms and the impact of school/nursery closures. The R0 for Asian influenza was about 1.8 and 60-65% of infected individuals were estimated to have experienced clinical symptoms. During a future pandemic, closure of schools/nurseries could reduce the epidemic size only by a very small amount (<10%) if R0 is high (e.g. 2.5 or 3.5), and modest reductions, e.g. 22% might be possible if it is low (1.8) and schools are closed early, depending on assumptions about contact patterns. Further data on contact patterns and their dependence on school closures are needed.
authors: Modelling and Economics Unit, Health Protection Agency Centre for Infections, Colindale, London, UK. emilia.vynnycky@hpa.org.uk
authors: E
authors: E
authors: Vynnycky
authors: W J
authors: WJ
authors: Edmunds
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D050936:Basic Reproduction Number; D002648:Child; D002675:Child, Preschool; D003140:Communicable Disease Control / Q000379:methods*; D004196:Disease Outbreaks; D006801:Humans; D015994:Incidence; D007223:Infant; D007251:Influenza, Human / Q000453:epidemiology* / Q000517:prevention & control / Q000635:transmission; D008875:Middle Aged; D015233:Models, Statistical; D012574:Schools; D013997:Time Factors; D006113:United Kingdom / Q000453:epidemiology