Anesthetic properties of some fluorinated oxolanes and oxetanes.
BACKGROUND
The search for new potent inhaled anesthetics has slowed, in large part because of the excellence of the two most recent additions, desflurane and sevoflurane. Nonetheless, neither desflurane nor sevoflurane are ideal anesthetics, desflurane causing cardiorespiratory stimulation, and sevoflurane having a slower (albeit rapid) recovery from anesthesia. Sevoflurane also can produce convulsions and postoperative agitation.


RESULTS
In the present report, we describe the physical and anesthetic properties of 31 cyclic ethers halogenated solely with fluorine. Although several produced anesthesia, none had solubilities that would make them better than sevoflurane. The remaining ethers were unstable or produced obvious central nervous system irritation, including convulsions.


CONCLUSIONS
We find that none of these cyclic ethers appear to provide advantages over desflurane or sevoflurane.
Eger
Edmond I
EI
Department of Anesthesia and Perioperative Care, University of California, San Francisco, California 94143-0464, USA. egere@anesthesia.ucsf.edu
Lemal
David
D
Laster
Michael J
MJ
Liao
Mark
M
Jankowska
Katarzyna
K
Raghavanpillai
Anilkumar
A
Popov
Anatoliy V
AV
Gan
Yonghong
Y
Lou
Yan
Y
D018685:Anesthetics, Inhalation / Q000009:adverse effects / Q000737:chemistry* / Q000494:pharmacology*; D000818:Animals; D002490:Central Nervous System / Q000187:drug effects; D004988:Ethers, Cyclic / Q000009:adverse effects / Q000737:chemistry* / Q000494:pharmacology*; D017611:Fluorine Compounds / Q000009:adverse effects / Q000737:chemistry / Q000494:pharmacology; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012640:Seizures / Q000139:chemically induced
D018685:Anesthetics, Inhalation; D004988:Ethers, Cyclic; D017611:Fluorine Compounds