Anti-inflammatory and antinociceptive properties of blueberry extract (Vaccinium corymbosum).
Blueberries are among the edible fruits that are recognized best for their potential health benefits. The crude extract from Vaccinium corymbosum was assessed in anti-inflammatory and antinociceptive models. The crude hydroalcoholic extract was administered orally at doses of 100, 200 or 300 mg kg (-1) for all the assays. In the carrageenan test, the crude extract reduced rat paw oedema by 9.8, 28.5 and 65.9%, respectively. For the histamine assay, the reductions of oedema were 70.1, 71.7 and 81.9%, respectively. In the myeloperoxidase (MPO) assay, 300 mg kg (-1) crude extract produced a significant inhibition of the MPO activity, at 6 h and 24 h after injection of carrageenan, by 42.8 and 46.2%, respectively. With the granulomatous tissue assay dexamethasone displayed significant activity, whereas the blueberry extract was inactive. For the abdominal constriction test, inhibitions of 49.0, 54.5, 53.5%, respectively, were observed for the crude extract, and 61.4% for indometacin. In the formalin test, the crude extract (200 and 300 mg kg (-1)) and indometacin inhibited only the second phase by 36.2, 35.3 and 45.8%, respectively. Considering that the crude extract of blueberry displayed antinociceptive and anti-inflammatory activity, its consumption may be helpful for the treatment of inflammatory disorders.
Torri
Eliane
E
Núcleo de Ciência e Tecnologia, Area de Ciências Biológicas e da Saúde, Universidade do Oeste de Santa Catarina, Campus de Videira, Rua Paese, 198, Bairro das Torres, Videira-SC, 89560-000, SC, Brazil.
Lemos
Marivane
M
Caliari
Vinícius
V
Kassuya
Cândida A L
CA
Bastos
Jairo K
JK
Andrade
Sérgio F
SF
D000005:Abdomen; D000700:Analgesics / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000494:pharmacology*; D002351:Carrageenan; D003251:Constriction, Pathologic / Q000139:chemically induced / Q000188:drug therapy; D003907:Dexamethasone / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy*; D005638:Fruit; D015745:Granuloma, Foreign-Body / Q000188:drug therapy; D006632:Histamine / Q000502:physiology; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D010147:Pain Measurement; D009195:Peroxidase / Q000187:drug effects / Q000378:metabolism; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D029796:Vaccinium
D000700:Analgesics; D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D003907:Dexamethasone; D006632:Histamine; D002351:Carrageenan; D009195:Peroxidase; D007213:Indomethacin