Synthesis and cytotoxic activity of certain 2,3,4,9-tetrahydrofuro [2,3-b] quinolin-3,4-dione and ethyl 2-(substituted aniline) -4-oxo-4,5-dihydrofuran-3-carboxylate derivatives in murine leukemia WEHI-3 cells.
A series of 2,3,4,9-tetrahydrofuro[2,3-b]quinolin-3,4-dione and ethyl 2-(substituted aniline) -4-oxo-4,5-dihydrofuran-3-carboxylate were synthesized and evaluated for cytotoxicity on murine leukemia WEHI-3 cells. The cytotoxic effects of most compounds tested were dose-dependent and the structure-activity relationships indicated that N-substituted benzyl derivatives displayed a stronger inhibitory activity against murine leukemia WEHI-3 cells compared to non-N-substituted benzyl substituted derivatives.
Huang
An-Cheng
AC
Graduate Institute of Pharmaceutical Chemistry, China Medical University, Taichung City, Taiwan, 404.
Chung
Jing-Gung
JG
Kuo
Sheng-Chu
SC
Lu
Hsu-Fung
HF
Lin
Tsung-Ping
TP
D000818:Animals; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects*; D005663:Furans / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity*; D007942:Leukemia, Experimental / Q000473:pathology*; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors; D015363:Quinolones / Q000138:chemical synthesis / Q000737:chemistry / Q000633:toxicity*; D013053:Spectrophotometry
D005663:Furans; C105213:HAJ11; D015363:Quinolones; C109999:HA 7; D011505:Protein-Tyrosine Kinases