title: Titanocene(II)-promoted stereoselective alkenylation utilizing (Z)-alkenyl sulfones.
abstract: The stereoselective alkenylation of unsaturated compounds by means of a (Z)-alkenyl sulfone-titanocene(II) system is described. Treatment of alkynes and (Z)-alkenyl methyl sulfones with the titanocene(II) reagent Cp2Ti[P(OEt)3]2 produced conjugated dienes. This alkenylation system is also applicable to polar C=O bonds; the simple mixing of carbonyl compounds, (Z)-alkenyl methyl sulfones, and the titanocene(II) reagent formed allylic alcohols. The advantages of alkenylation are that it requires no prepreparation of the alkenylmetal reagent and that it proceeds with complete stereoselectivity.
authors: Department of Applied Chemistry, Graduate School of Engineering, Tokyo University of Agriculture and Technology, Koganei, Tokyo 184-8588, Japan.
authors: Akitoshi
authors: A
authors: Ogata
authors: Masami
authors: M
authors: Nemoto
authors: Kenji
authors: K
authors: Kobayashi
authors: Akira
authors: A
authors: Tsubouchi
authors: Takeshi
authors: T
authors: Takeda