[Age-related muscle mass loss].
One of the signs of advancing age in humans is sarcopenia. The term is used to define the loss of muscle mass and strength that occurs with ageing. Sarcopenia contributes to the decreased capacity of independent living and increased amounts of traumas. Numbers of mechanisms are proposed as a cause of sarcopenia, including changes in protein metabolism, alterations in hormonal and neural functions, impaired regeneration after contraction-induced injuries, mitochondrial abnormalities, oxidative stress and apoptosis in skeletal muscle fibres. Further studies on the mechanisms leading to sarcopenia could provide the basis for prevention and establishment of therapeutic methods that would contribute to an increase in the standard of living among elderly people.
Czarkowska-Paczek
Bozena
B
Zakład Biofizyki i Fizjologii Człowieka, Akademia Medyczna Warszawie. dom_paczek@o2.pl
Milczarczyk
Sylwia
S
D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000378:metabolism / Q000473:pathology / Q000502:physiology*; D017209:Apoptosis / Q000502:physiology; D001823:Body Composition / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009119:Muscle Contraction / Q000502:physiology; D009124:Muscle Proteins / Q000378:metabolism*; D018908:Muscle Weakness / Q000503:physiopathology; D018482:Muscle, Skeletal / Q000378:metabolism / Q000473:pathology / Q000502:physiology*; D009133:Muscular Atrophy / Q000378:metabolism* / Q000503:physiopathology; D009210:Myofibrils / Q000378:metabolism; D009929:Organ Size / Q000502:physiology; D011788:Quality of Life; D012038:Regeneration / Q000502:physiology; D013710:Tendons / Q000378:metabolism
D009124:Muscle Proteins