Introducing histone modification in trypanosomes.
Nuclear DNA is wrapped around histones. Vigorous research over the past decade has established a central role for histone post-translational modification in controlling the DNA-protein interactions that are required for successful growth and propagation. Recent work now provides a description of acetylated and methylated residues in the divergent trypanosome core histones. Future studies should provide insights into the genomic distribution of each modification and their roles in growth and pathogenesis.
Horn
David
D
London School of Hygiene & Tropical Medicine, Keppel Street, London, UK. david.horn@lshtm.ac.uk
D000107:Acetylation; D000818:Animals; D016054:DNA, Protozoan / Q000235:genetics / Q000378:metabolism; D006657:Histones / Q000737:chemistry / Q000235:genetics / Q000302:isolation & purification / Q000378:metabolism*; D013058:Mass Spectrometry; D008745:Methylation; D011499:Protein Processing, Post-Translational; D015800:Protozoan Proteins / Q000737:chemistry / Q000235:genetics / Q000302:isolation & purification / Q000378:metabolism; D014346:Trypanosoma brucei brucei / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D014349:Trypanosoma cruzi / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*
D016054:DNA, Protozoan; D006657:Histones; D015800:Protozoan Proteins