Chemomicin A, a new angucyclinone antibiotic produced by Nocardia mediterranei subsp. kanglensis 1747-64.
A new angucyclinone antibiotic, chemomicin A was isolated from cultured broth of Nocardia mediterranei subsp. kanglensis 1747-64. Its chemical structure was determined to be 1,2,3,4a,5,6,6a,12a,12b-nonahydro-1,2,3,8,12,12b-hexahydroxy-3-methyl-6a,12a-epoxybenz[a]anthracen-4,7(12H)-dione by a detailed spectroscopic analysis. Chemomicin A had antimicrobial activity against Bacillus subtilis and Enterococcus faecium with MIC values of 10.2 and 20.4 microM, respectively, and showed cytotoxicity against human colorectal cancer HCT116 cells and human esophageal carcinoma YES-2 cells with IC50 values of 127 and 153 microM, respectively.
Sun
Cheng-Hang
CH
Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, PR China. chenghangsun@hotmail.com
Wang
Yue
Y
Wang
Zheng
Z
Zhou
Jian-Qin
JQ
Jin
Wen-Zao
WZ
You
Xue-Fu
XF
Gao
Hong
H
Zhao
Li-Xun
LX
Si
Shu-Yi
SY
Li
Xue
X
D000880:Anthraquinones / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology; D001412:Bacillus subtilis / Q000187:drug effects*; D045744:Cell Line, Tumor; D016984:Enterococcus faecium / Q000187:drug effects*; D005285:Fermentation; D006801:Humans; D020128:Inhibitory Concentration 50; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009615:Nocardia / Q000145:classification / Q000254:growth & development / Q000378:metabolism*
D000880:Anthraquinones; D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; C510997:angucyclinone; C520923:chemomicin A