A concise synthesis of butylcycloheptylprodigiosin.
A short and efficient total synthesis of the tripyrrole alkaloid butylcycloheptylprodigiosin is described. Key to the brevity of the approach is a two-step synthesis of macrocyclic formylpyrrole 4 from cyclononenone 6.
Reeves
Jonathan T
JT
Department of Chemical Development, Boehringer Ingelheim Pharmaceuticals Inc, Ridgefield, CT 06877, USA. jreeves@rdg.boehringer-ingelheim.com
D005561:Formates / Q000737:chemistry; D006868:Hydrolysis; D006900:Hydroxylation; D007659:Ketones / Q000138:chemical synthesis / Q000737:chemistry; D015394:Molecular Structure; D011353:Prodigiosin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry
D005561:Formates; D007659:Ketones; C513603:butylcycloheptylprodigiosin; C030544:formic acid; D011353:Prodigiosin