[Pathogenesis of the hepatocellular carcinoma associated with hepatitis C virus].
Hepatitis C virus (HCV) is known as one of major causative agents of hepatocellular carcinoma (HCC) in the world. The pathogenesis of HCC associated with HCV, however, has not been fully elucidated yet, although the chronic inflammation induced by HCV infection is considered to contribute greatly to the HCC development. Some HCV gene products have been shown to possess transformation activities in cultured cells. Several oncogenic signal pathways in the cells were modulated by the exogenous expression of the HCV proteins. A few lines of the transgenic mice producing the core protein among those products was also reported to develop liver steatosis and HCC without apparent inflammation after rearing for a relatively long period. So, the functions of the core on the modulation of cellular events have been extensively examined and characterized. Here, I would summarize the progress of the research for the pathogenesis of HCC associated with HCV.
Hijikata
Makoto
M
Laboratory of Human Tumor Viruses Department of Viral Oncology Institute for Virus Research, Kyoto University, Sakyo-ku, Kyoto, Japan. mhijikat@virus.kyoto-u.ac.jp
D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000235:genetics / Q000821:virology*; D016174:Hepacivirus / Q000235:genetics* / Q000472:pathogenicity*; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics / Q000821:virology*; D051379:Mice; D017382:Reactive Oxygen Species; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology; D014170:Transformation, Genetic; D014758:Viral Core Proteins / Q000502:physiology*
D017382:Reactive Oxygen Species; D014758:Viral Core Proteins; C069130:nucleocapsid protein, Hepatitis C virus