Formulation and characterization of formaldehyde cross-linked degradable starch microspheres containing terbutaline sulfate.
Preparation of starch microspheres using epichlorohydrin is a time consuming method and requires around 18 hr for cross-linking reaction. To reduce reaction time, terbutaline sulfate (TBS) loaded degradable starch microspheres (DSM) were prepared using formaldehyde as the cross-linking agent. All microspheres were spherical in shape and had a porous, rough surface with a mean particle size of 18-24 microm. Whatever the cross-linking time, it was seen that the release of the TBS was not complete during the release experiments. The influence of enzyme on the degradation of microspheres was moderate. Following intravenous administration, initial uptake of microspheres by the lung was higher than those of other organs.
Selek
Handan
H
Faculty of Pharmacy, Hacettepe University, Ankara, Turkey.
Sahin
Selma
S
Kas
H Suheyla
HS
Hincal
A Atilla
AA
Ponchel
Gilles
G
Ercan
Meral T
MT
Sargon
Mustafa
M
D000318:Adrenergic beta-Agonists / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D000818:Animals; D019540:Area Under Curve; D001682:Biological Availability; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D003432:Cross-Linking Reagents / Q000737:chemistry*; D004058:Diffusion; D004305:Dose-Response Relationship, Drug; D004339:Drug Compounding / Q000379:methods; D005557:Formaldehyde / Q000737:chemistry*; D005612:Freeze Drying / Q000379:methods; D006207:Half-Life; D007275:Injections, Intravenous; D008168:Lung / Q000378:metabolism; D008297:Male; D051379:Mice; D008855:Microscopy, Electron, Scanning; D010316:Particle Size; D013213:Starch / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D013726:Terbutaline / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D014018:Tissue Distribution
D000318:Adrenergic beta-Agonists; D003432:Cross-Linking Reagents; C083286:degradable starch microspheres; D005557:Formaldehyde; D013213:Starch; D013726:Terbutaline