Ternary complexes of flurbiprofen with HP-beta-CD and ethanolamines characterization and transdermal delivery.
Binary and multicomponent systems complexes prepared with HP-beta-CD and/or with monoethanolamine (MEA), diethanolamine (DEA) or triethanolamine (TEA) were obtained. The results of solid-state studies indicated the presence of strong interactions between the components in the binary and the ternary systems. Drug solubility and dissolution rate in water were notably improved by employing the HP-beta-CD and the alkanolamines. The combined use of cosolvency and complexation with MEA in the presence of HP-beta-CD on the permeation of flurbiprofen through the human skin was evaluated. The combination of IPM, PG, and HP-beta-CD yield the highest permeation for the flurbiprofen-MEA complex.
Maitre
Marcos M
MM
Departamento de Farmacia, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Ciudad Universitaria, Córdoba, Argentina.
Longhi
Marcela R
MR
Granero
Gladys G
GG
D000073738:2-Hydroxypropyl-beta-cyclodextrin; D000279:Administration, Cutaneous; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry* / Q000493:pharmacokinetics; D004983:Ethanolamines / Q000737:chemistry* / Q000494:pharmacology; D005480:Flurbiprofen / Q000737:chemistry* / Q000493:pharmacokinetics; D006801:Humans; D012869:Skin Absorption / Q000187:drug effects*; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D047392:beta-Cyclodextrins / Q000737:chemistry* / Q000494:pharmacology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004983:Ethanolamines; D047392:beta-Cyclodextrins; D000073738:2-Hydroxypropyl-beta-cyclodextrin; D005480:Flurbiprofen