[Mechanisms of EBV-mediated oncogenesis].
Epstein-Barr virus (EBV) is the DNA tumor virus, which is known to be relevant to various cancers. EBV maintains latent infection in cancer cells, and there are three types of latent infection (type I-III) according to the patterns of viral latent genes expression. EBV has the ability to transform B cells into immortalized lymphoblastoid cell lines (LCL) showing type III latency, in which all latent genes are expressed. The mechanism of B-cell transformation has provided a model of EBV-associated lymphomas in immunosuppressed individuals. In type I and II latency, the limited numbers of latent genes are expressed. Previous studies have demonstrated the oncogenic functions of latent EBV genes including nuclear antigen EBNA1, membrane protein LMP1 and LMP2A. In addition, we have demonstrated that EBV-encoded small RNA EBERs play a significant role in oncogenesis. Here we summarize recent progresses in the studies on molecular mechanisms of EBV-mediated oncogenesis.
Iwakiri
Dai
D
Department of Tumor Virology, Institute for Genetic Medicine, Hokkaido University, Kita-ku, Sapporo, Japan. iwakiri@igm.hokudai.ac.jp
Samanta
Mrinal
M
Takada
Kenzo
K
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D019309:Epstein-Barr Virus Nuclear Antigens / Q000502:physiology; D004854:Herpesvirus 4, Human / Q000235:genetics* / Q000472:pathogenicity*; D006801:Humans; D016867:Immunocompromised Host; D008213:Lymphocyte Activation; D009369:Neoplasms / Q000821:virology*; D012367:RNA, Viral / Q000502:physiology; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology; D014763:Viral Matrix Proteins / Q000502:physiology
C037662:EBV-associated membrane antigen, Epstein-Barr virus; D019309:Epstein-Barr Virus Nuclear Antigens; C099537:Epstein-Barr virus encoded RNA 1; C106732:Epstein-Barr virus encoded RNA 2; D012367:RNA, Viral; D014763:Viral Matrix Proteins; C417029:EBV-encoded nuclear antigen 1