title: beta(2)-Adrenergic receptor-dependent sexual dimorphism for murine leukocyte migration.
abstract: In wild-type FVB mice, leukocyte recruitment to lipopolysaccharide was sexually dimorphic, with a greater number of leukocytes recruited in females. In male beta(2)-adrenergic receptor knock out mice (bred on a congenic FVB background) the number of leukocytes recruited was increased approximately 4-fold, while in females there was no change, eliminating sexual dimorphism in leukocyte migration. While there were significantly fewer recruited CD62L(+) and CD11a(+) leukocytes in wild-type males, only in male beta-adrenergic receptor knock out mice was there an increase in the number of recruited CD11a(+) leukocytes, again eliminating sexual dimorphism. Thus, leukocyte migration and CD11a(+) adhesion molecule expression in male, but not in female, leukocytes is beta-adrenergic receptor-dependent. Our findings provide support for a role of beta(2)-adrenergic receptor mechanisms in the inflammatory response, and suggest that beta(2)-adrenergic receptor on male leukocytes contributes to sexual dimorphism in the effect of stress on inflammatory diseases.
authors: Department of Medicine and Oral and Maxillofacial Surgery, 521 Parnassus Avenue, UCSF, San Francisco, CA 94143, USA.
authors: Catherine
authors: C
authors: de Coupade
authors: Adrienne S
authors: AS
authors: Brown
authors: Paul F
authors: PF
authors: Dazin
authors: Jon D
authors: JD
authors: Levine
authors: Paul G
authors: PG
authors: Green
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D040881:CD11a Antigen / Q000378:metabolism; D015496:CD4-Positive T-Lymphocytes / Q000502:physiology; D002465:Cell Movement / Q000187:drug effects / Q000502:physiology*; D005260:Female; D019041:L-Selectin / Q000378:metabolism; D007962:Leukocytes / Q000187:drug effects / Q000502:physiology*; D008070:Lipopolysaccharides / Q000494:pharmacology; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D009504:Neutrophils / Q000166:cytology / Q000187:drug effects; D018343:Receptors, Adrenergic, beta-2 / Q000172:deficiency / Q000502:physiology*; D012727:Sex Characteristics
chemical_list: D040881:CD11a Antigen; D008070:Lipopolysaccharides; D018343:Receptors, Adrenergic, beta-2; D019041:L-Selectin