title: Predictors for silent cerebral infarction in patients with chronic renal failure undergoing hemodialysis.
abstract: In patients with chronic renal failure undergoing hemodialysis (HD), silent cerebral infarctions (SCIs) are associated with high mortality. Levels of hepatocyte growth factor (HGF) increase with renal dysfunction and may be a novel predictor of cerebrovascular events. We examined if HGF is a predictor of SCI in HD patients. Brain magnetic resonance imaging findings were used to divide 50 patients undergoing HD into 2 groups, a group with SCI (age, 61 +/- 8 years, mean +/- SD; n = 27) and a group without SCI (age, 60 +/- 7 years; n = 23). These patients received 24-hour ambulatory blood pressure monitoring. The number of patients with diabetes or hypertension was not different between the 2 groups. We made the following observations: (1) The percentage of smokers was higher in the group with SCI than in the group without SCI (P < .05). (2) Plasma levels of high-density lipoprotein cholesterol were lower and HGF levels were higher in the group with SCI compared with the group without SCI (P < .05 and P < .005, respectively). (3) Systolic ambulatory blood pressure and mean heart rate at night were higher in the group with SCI than in the group without SCI (P < .05). Multiple logistic regression analysis identified HGF as a significant risk factor for SCI (odds ratio, 1.89; 95% confidence interval, 1.57-3.38; P < .005). Our findings indicate that HGF may be a novel useful predictor of SCI in patients with chronic renal failure undergoing HD.
authors: Department of Cardiology, Oita Red Cross Hospital, Oita, Japan. anan-f@med.oita-u.ac.jp
authors: Futoshi
authors: F
authors: Anan
authors: Tsuyoshi
authors: T
authors: Shimomura
authors: Masaharu
authors: M
authors: Imagawa
authors: Takayuki
authors: T
authors: Masaki
authors: Tomoko
authors: T
authors: Nawata
authors: Naohiko
authors: N
authors: Takahashi
authors: Hidetoshi
authors: H
authors: Yonemochi
authors: Nobuoki
authors: N
authors: Eshima
authors: Tetsunori
authors: T
authors: Saikawa
authors: Hironobu
authors: H
authors: Yoshimatsu
mesh_terms: D018660:Blood Pressure Monitoring, Ambulatory; D001921:Brain / Q000473:pathology; D002544:Cerebral Infarction / Q000097:blood / Q000150:complications* / Q000473:pathology; D015150:Echocardiography, Doppler; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D017228:Hepatocyte Growth Factor / Q000097:blood*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000150:complications* / Q000628:therapy; D016015:Logistic Models; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D006435:Renal Dialysis
chemical_list: D017228:Hepatocyte Growth Factor