Regulation of lymphocyte development by Notch signaling.
Notch molecules are well conserved from Drosophila melanogaster to mammals and regulate a broad spectrum of various cell lineage commitment processes. Recent studies using inhibitors, transgenic mice and conditional loss-of-function approaches have demonstrated essential roles for Notch signaling in the differentiation of thymocytes and peripheral T cells, as well as B cells. Here we highlight parallels in the developmental regulation of mammalian lymphocytes and the D. melanogaster nervous system through Notch cooperation with the transcriptional regulators RBP-J (Su(H)), MINT (Hairless) and E2A (Ac-Sc-Da).
Tanigaki
Kenji
K
Research Institute, Shiga Medical Center, 5-4-30 Moriyama, Moriyama-shi, Shiga 524-8524 Japan.
Honjo
Tasuku
T
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology / Q000502:physiology*; D019070:Cell Lineage; D006410:Hematopoiesis; D006801:Humans; D038041:Lymphopoiesis; D051880:Receptors, Notch / Q000502:physiology*; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000276:immunology / Q000502:physiology*
D051880:Receptors, Notch