title: Biotransformation of cinobufagin by Cunninghamella elegans.
abstract: Cunninghamella elegans has been employed for the biotransformation of cinobufagin to afford 5 metabolites. The structures of the transformation products have been characterized as 12alpha-hydroxybufagin, 11alpha-hydroxybufagin, 12beta-hydroxy-desacetylcinobufagin, 3-oxo-12alpha-hydroxybufagin and 12beta-hydroxybufagin. Products 12alpha-hydroxybufagin and 11alpha-hydroxybufagin are new compounds. In vitro both the biotransformation products and cinobufagin all showed cytotoxic activities against HeLa cells.
authors: School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University.
authors: Li
authors: L
authors: Qiao
authors: Yu-Zhi
authors: YZ
authors: Zhou
authors: Xiu-Lan
authors: XL
authors: Qi
authors: Li-Hong
authors: LH
authors: Lin
authors: Huan
authors: H
authors: Chen
authors: Li-Yan
authors: LY
authors: Pang
authors: Yue-Hu
authors: YH
authors: Pei
mesh_terms: D001711:Biotransformation; D002018:Bufanolides / Q000378:metabolism* / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D020093:Cunninghamella / Q000378:metabolism*; D006367:HeLa Cells; D006801:Humans; D013329:Structure-Activity Relationship
chemical_list: D002018:Bufanolides; C002471:cinobufagin