title: A composite adenoendocrine carcinoma of the stomach arising from a neuroendocrine tumor.
abstract: Gastric neuroendocrine tumors (carcinoids) are relatively uncommon neoplasms. Some 70 to 80% of these lesions occur in patients with autoimmune body gastritis. This disorder, however, is also a risk factor for the development of conventional gastric adenocarcinomas. We report a case of a patient with autoimmune body gastritis and a well-differentiated neuroendocrine tumor of the stomach, which was removed with endoscopic full-thickness resection in sano upon signs of invasive growth several years after its first diagnosis. Histological examination surprisingly showed a composite glandular-endocrine gastric carcinoma. We discuss the histopathological genesis of the tumor and provide evidence that endoscopic full-thickness resection might be an oncologically appropriate minimally invasive treatment for such gastric lesions.
authors: Department of Surgery, University Hospital Mannheim, Ruprecht-Karls-University Heidelberg, Theodor-Kutzer-Ufer 1-3, Mannheim, 68135, Germany. ulrich.ronellenfitsch@chir.ma.uni-heidelberg.de
authors: Ulrich
authors: U
authors: Ronellenfitsch
authors: Philipp
authors: P
authors: Ströbel
authors: Matthias H M
authors: MH
authors: Schwarzbach
authors: Wilko I
authors: WI
authors: Staiger
authors: Dieter
authors: D
authors: Gragert
authors: Georg
authors: G
authors: Kähler
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism / Q000473:pathology*; D002454:Cell Differentiation; D053379:Chromogranin A / Q000378:metabolism; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D018358:Neuroendocrine Tumors / Q000378:metabolism / Q000473:pathology*; D013274:Stomach Neoplasms / Q000378:metabolism / Q000473:pathology*
chemical_list: D053379:Chromogranin A