Propofol hemisuccinate suppression of experimental autoimmune encephalomyelitis.
Propofol hemisuccinate is a prodrug water soluble form of the lipophilic, phenolic compound propofol (2,6-di-isopropylphenol), that is the active ingredient in the widely used anesthetic agent Diprovan. Propofol binds to GABA(A) receptors but also has a phenolic structure that confers antioxidant properties to the molecule. The effects of propofol hemisuccinate in rat experimental autoimmune encephalomyelitis (EAE) were studied using different doses and time regimes. Propofol hemisuccinate, 100 mg/kg given three times a day from day 7 or day 12 until day 16 after disease initiation, significantly reduced maximal EAE score. Histology studies supported the clinical findings demonstrating reduction in the inflammatory response in the lumbar spinal cord in animals treated with propofol hemisuccinate. Decreased levels of nitrotyrosine and unchanged levels of induced nitric oxide synthase suggest propofol hemisuccinate crossed the blood brain barrier and exerted its effects by lowering reactive oxygen species levels. The results suggest that propofol hemisuccinate may provide an alternative mode of treatment for acute exacerbations of multiple sclerosis.
Vansant
G
G
Althea Technologies, 11040 Roselle Street, San Diego, CA 92121, USA. gvansant@altheatech.com
Trauger
R J
RJ
Cameron
A
A
Vendemelio
M
M
Kreitschitz
S
S
Carlo
A T
AT
Banaszczyk
M G
MG
Carlo
D J
DJ
Hendler
S
S
Ill
C R
CR
D018686:Anesthetics, Intravenous / Q000494:pharmacology*; D000818:Animals; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000188:drug therapy*; D008297:Male; D015742:Propofol / Q000494:pharmacology*; D051381:Rats; D011917:Rats, Inbred Lew; D019802:Succinic Acid / Q000494:pharmacology*
D018686:Anesthetics, Intravenous; D019802:Succinic Acid; D015742:Propofol