title: Factor VII polymorphisms influence the plasma response to diets with different fat content, in a healthy Caucasian population.
abstract: To determine the influence of the factor VII gene polymorphisms, R353Q and 5'F7, on factor VII Ag plasma levels after the consumption of diets with different fat contents.
  
  
  METHODS
  59 healthy individuals (42 RR, 16 RQ, 1 QQ at the R353Q and 46 A1A1, 13 A1A2 at the 5'F7) consumed 3 diets during 4-weeks each: a Saturated diet (SAT) enriched in saturated fatty acid (SFA) (38% fat, 20% SFA), followed by a carbohydrate (CHO)-rich diet (30% fat, 55% CHO) or a Mediterranean diet (MEDIT) enriched in monounsaturated fatty acid (MUFA) (38% fat, 22% MUFA) following a randomized crossover design. Plasma lipids and FVII Ag plasma levels were determined at the end of each dietary period.
  
  
  RESULTS
  After a SAT diet, RR homozygotes had greater concentrations of FVII Ag compared with MEDIT and CHO diets than did carriers of the minority Q allele (82.76 +/- 1.3 vs. 75.02 +/- 2.4, p = 0.001). The 5'F7 polymorphism behaved in a similar fashion (A1A1 81.98 +/- 1.4 vs. A1A2 75.37 +/- 2.4, p = 0.026).
  
  
  CONCLUSIONS
  Our data show that carriers of the RR and/or A1A1 genotype present higher FVII Ag levels after the consumption of a SAT diet compared with the MEDIT and CHO rich diets.
authors: Reina Sofia University Hospital, Lipids and Atherosclerosis Research Unit, University of Cordoba, Ciber Fisiopatologia Obesidad y Nutricion, Instituto Salud Carlos III, Cordoba, Spain.
authors: Rafael Angel
authors: RA
authors: Fernández de la Puebla
authors: Pablo
authors: P
authors: Pérez-Martínez
authors: José
authors: J
authors: Carmona
authors: José
authors: J
authors: López-Miranda Carmen Marín
authors: Juan Antonio
authors: JA
authors: Paniagua
authors: Francisco
authors: F
authors: Fuentes
authors: Francisco
authors: F
authors: Pérez-Jiménez
mesh_terms: D000328:Adult; D018592:Cross-Over Studies; D038441:Diet, Mediterranean; D004040:Dietary Carbohydrates / Q000008:administration & dosage; D004041:Dietary Fats / Q000008:administration & dosage*; D005167:Factor VII / Q000032:analysis* / Q000235:genetics*; D005227:Fatty Acids / Q000008:administration & dosage; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic
chemical_list: D004040:Dietary Carbohydrates; D004041:Dietary Fats; D005227:Fatty Acids; D005167:Factor VII