title: A genome-wide genotyping study in patients with ischaemic stroke: initial analysis and data release.
abstract: BACKGROUND
  Despite evidence of a genetic role in stroke, the identification of common genetic risk factors for this devastating disorder remains problematic. We aimed to identify any common genetic variability exerting a moderate to large effect on risk of ischaemic stroke, and to generate publicly available genome-wide genotype data to facilitate others doing the same.
  
  
  METHODS
  We applied a genome-wide high-density single-nucleotide-polymorphism (SNP) genotyping approach to a cohort of samples with and without ischaemic stroke (n=278 and 275, respectively), and did an association analysis adjusted for known confounders in a final cohort of 249 cases and 268 controls. More than 400,000 unique SNPs were assayed.
  
  
  RESULTS
  We produced more than 200 million genotypes in 553 unique participants. The raw genotypes of all the controls have been posted publicly in a previous study of Parkinson's disease. From this effort, results of genotype and allele association tests have been publicly posted for 88% of stroke patients who provided proper consent for public release. Preliminary analysis of these data did not reveal any single locus conferring a large effect on risk for ischaemic stroke.
  
  
  CONCLUSIONS
  The data generated here comprise the first phase of a genome-wide association analysis in patients with stroke. Release of phase I results generated in these publicly available samples from each consenting individual makes this dataset a valuable resource for data-mining and augmentation.
authors: Molecular Genetics Unit, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.
authors: Mar
authors: M
authors: Matarín
authors: W Mark
authors: WM
authors: Brown
authors: Sonja
authors: S
authors: Scholz
authors: Javier
authors: J
authors: Simón-Sánchez
authors: Hon-Chung
authors: HC
authors: Fung
authors: Dena
authors: D
authors: Hernandez
authors: J Raphael
authors: JR
authors: Gibbs
authors: Fabienne Wavrant
authors: FW
authors: De Vrieze
authors: Cynthia
authors: C
authors: Crews
authors: Angela
authors: A
authors: Britton
authors: Carl D
authors: CD
authors: Langefeld
authors: Thomas G
authors: TG
authors: Brott
authors: Robert D
authors: RD
authors: Brown
authors: Bradford B
authors: BB
authors: Worrall
authors: Michael
authors: M
authors: Frankel
authors: Scott
authors: S
authors: Silliman
authors: L Douglas
authors: LD
authors: Case
authors: Andrew
authors: A
authors: Singleton
authors: John A
authors: JA
authors: Hardy
authors: Stephen S
authors: SS
authors: Rich
authors: James F
authors: JF
authors: Meschia
mesh_terms: D000368:Aged; D000483:Alleles; D002545:Brain Ischemia / Q000150:complications*; D015331:Cohort Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D015894:Genome, Human; D005838:Genotype; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D020521:Stroke / Q000209:etiology* / Q000235:genetics