Limits of usual biochemical alcohol markers in cord blood at term: a fetal/maternal population-based study.
BACKGROUND
After maternal alcohol consumption during pregnancy, many neonates affected by less apparent forms of fetal alcohol syndrome disorder (FASD) do not receive proper diagnosis or treatment. There is thus a need for laboratory markers for early detection of alcohol-exposed neonates. The aim of our study was to assess the efficiency of the usual alcohol biomarkers measured in cord blood to identify alcohol-exposed neonates immediately after birth.


METHODS
A 1-year study was conducted in the labor wards of the maternity units of the Auvergne, Central France at the time of term delivery. The patients answered an anonymous self-completion survey concerning alcohol use (Alcohol Use Disorder Identification Test; AUDIT) during their pregnancy. Aspartate aminotransferase, alanine aminotransferase, and gamma-glutamyltransferase concentrations and the percentage of carbohydrate-deficient transferrin were measured in maternal and cord blood.


RESULTS
We collected 870 maternal-fetal sample pairs. Two cases (0.2%) of typical FASD were detected. We report a non-significant correlation between maternal and cord blood biomarkers. None of the cord blood biomarkers differed significantly between newborns of alcohol-exposed and unexposed mothers.


CONCLUSIONS
We demonstrate that the usual alcohol biomarkers are not effective in cord blood for identifying alcohol-exposed neonates.
Gallot
Denis
D
Université d'Auvergne, JE2447, ARDEMO, and CHU, Maternité Hôtel-Dieu, Clermont-Ferrand, France.
de Chazeron
Ingrid
I
Boussiron
Didier
D
Ughetto
Sylvie
S
Vendittelli
Françoise
F
Legros
Franz J
FJ
Roszyk
Laurence
L
Llorca
Pierre-Michel
PM
Lemery
Didier
D
Sapin
Vincent
V
D015415:Biomarkers / Q000097:blood*; D000431:Ethanol / Q000097:blood*; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D006801:Humans; D007231:Infant, Newborn; D015997:Neonatal Screening; D011247:Pregnancy; D011446:Prospective Studies
D015415:Biomarkers; D000431:Ethanol