Next steps in Alzheimer's disease research: interaction between epidemiology and basic science.
Epidemiologic studies have provided important clues about the etiology, prognosis and options for prevention and treatment of AD, and sub-clinical changes in cognition and brain structure. A brief review is given of what we have learned from epidemiologic studies of risk factors and natural history. This is followed by a discussion of how these findings could inform the design of basic research strategies that may further the translation of bench science to the clinic and public health arena.
Launer
Lenore J
LJ
National Institute on Aging, Bethesda, MD 20892, USA. launerl@nia.nih.gov
D000544:Alzheimer Disease / Q000453:epidemiology* / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology*; D016021:Epidemiologic Studies; D006801:Humans; D012106:Research / Q000639:trends*; D012307:Risk Factors