Predictors of an accurate preoperative sestamibi scan for single-gland parathyroid adenomas.
OBJECTIVE
To investigate why some patients with single parathyroid adenomas have negative preoperative sestamibi scans.


METHODS
Retrospective review.


METHODS
Tertiary care center.


METHODS
Twenty-one patients with false-negative (FN) scans were compared with 22 patients with true-positive (TP) scans. All patients had single parathyroid adenomas.


METHODS
Neck exploration and removal of parathyroid adenomas.


METHODS
Age; sex; preoperative serum calcium and parathyroid hormone levels; gland weight; location; and pathologic features.


RESULTS
There was no significant difference in age or preoperative serum calcium or parathyroid hormone levels. Gland weight was greater in the TP group compared with the FN group (mean +/- SD, 1336 +/- 1603 mg vs 475 +/- 365 mg; P = .04); 13 (62%) of the 21 glands in the FN group were located in the upper position, compared with 6 (27%) of the 22 glands in the TP group (P = .03). Ten of the 22 glands in the TP group consisted predominantly of oxyphil cells, compared with 2 of the 21 glands in the FN group (P = .02). A multivariate logistic regression model yielded the following factors that predicted an accurate scan: higher percentage of oxyphil cells (P = .03), heavier gland (P = .03), female sex (P = .04), and gland location in the lower position (P = .04).


CONCLUSIONS
Smaller-volume parathyroid adenomas and those in the upper position are less likely to be localized with sestamibi scans. A TP scan correlates with oxyphil cell predominance, supporting a role for the mitochondrial-rich cell in sestamibi uptake and retention.
Stephen
Antonia E
AE
Department of Surgical Oncology, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA. astephen@partners.org
Roth
Sanford I
SI
Fardo
David W
DW
Finkelstein
Dianne M
DM
Randolph
Gregory W
GW
Gaz
Randall D
RD
Hodin
Richard A
RA
D000236:Adenoma / Q000000981:diagnostic imaging* / Q000601:surgery; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005188:False Negative Reactions; D005189:False Positive Reactions; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010282:Parathyroid Neoplasms / Q000000981:diagnostic imaging* / Q000601:surgery; D016105:Parathyroidectomy / Q000379:methods*; D011237:Predictive Value of Tests; D011300:Preoperative Care / Q000379:methods*; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D012189:Retrospective Studies; D017256:Technetium Tc 99m Sestamibi
D019275:Radiopharmaceuticals; D017256:Technetium Tc 99m Sestamibi