Novel physically crosslinked polyurethane-block-poly(vinyl pyrrolidone) hydrogel biomaterials.
Successful tissue repair and regeneration relies on the design of new biomaterials that can mediate cell interaction without inflicting undesirable responses. Novel physically crosslinked polyurethane-block-poly(vinyl pyrrolidone) hydrogel biomaterials were synthesized by the macroiniferter controlled radical polymerization method. The structures of the hydrogels were studied by FT-IR and (1)H NMR. Hydrogels with EWC up to 37 wt.-% were prepared. The presence of the PVP block significantly increased the hard-segment glass transition temperature. Vascular smooth muscle cell attachment and spreading on the hydrogels indicated that these materials have a potential for use as scaffolds in tissue engineering.
Patel
Alpesh
A
Department of Chemical and Biochemical Engineering, University of Western Ontario, London, ON N6A 5B9, Canada.
Mequanint
Kibret
K
D001672:Biocompatible Materials / Q000737:chemistry*; D003331:Coronary Vessels / Q000166:cytology; D006801:Humans; D020100:Hydrogels / Q000737:chemistry*; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D032389:Myocytes, Smooth Muscle / Q000166:cytology; D011140:Polyurethanes / Q000737:chemistry*; D011205:Povidone / Q000737:chemistry*; D014945:Wound Healing
D001672:Biocompatible Materials; D020100:Hydrogels; D011140:Polyurethanes; D011205:Povidone