Association between embB codon 306 mutations and drug resistance in Mycobacterium tuberculosis.
embB306 mutants were detected in both ethambutol (EMB)-resistant and EMB-susceptible strains of Mycobacterium tuberculosis. Multidrug-resistant (MDR) strains had a higher proportion of embB306 mutants than non-MDR strains (odds ratio, 6.78; P < 0.001). The embB306 locus is a candidate marker for rapid detection of MDR and extremely drug resistant tuberculosis.
Shen
Xin
X
Key Laboratory of Medical Molecular Virology, Shanghai Medical College, Fudan University, Shanghai 20032, China.
Shen
Guo-miao
GM
Wu
Jie
J
Gui
Xiao-hong
XH
Li
Xia
X
Mei
Jian
J
DeRiemer
Kathryn
K
Gao
Qian
Q
D000995:Antitubercular Agents / Q000494:pharmacology*; D003062:Codon / Q000235:genetics*; D004269:DNA, Bacterial / Q000235:genetics; D024881:Drug Resistance, Bacterial / Q000235:genetics; D004977:Ethambutol / Q000494:pharmacology*; D006801:Humans; D009154:Mutation; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000235:genetics* / Q000302:isolation & purification; D012680:Sensitivity and Specificity
D000995:Antitubercular Agents; D003062:Codon; D004269:DNA, Bacterial; D004977:Ethambutol