title: [Effects of brain stem and spinal cord by isoflurane inhibiting nociceptive reflex].
abstract: OBJECTIVE
  To explore the effect positions of the volatile anesthetic inhibiting the nociceptive reflex in the central nervous system.
  
  
  METHODS
  Thirty adult SD rats were randomly and equally divided into two groups that the lip and hind paw of rats were held by clamp. The minimum alveolar concentration (MAC) was determined by clamping two places: one was to clamp the hind paw of rats, of which the nervous reflex is controlled via the spinal cord; the another group was to clamp the lip of rats, of which the nervous reflex is controlled through the brain stem.
  
  
  RESULTS
  The isoflurane MAC was 1.44% +/- 0.09% in clamping the hind paw group, while 1.29% +/- 0.11% for clamping the lip group (P < 0.05).
  
  
  CONCLUSIONS
  Both brain stem and spinal cord are the effect positions of volatile anesthetics (especially isoflurane).
authors: Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu 610041, China.
authors: Jing
authors: J
authors: Yang
authors: Xiao-Wei
authors: XW
authors: Wang
authors: Zi-Yun
authors: ZY
authors: Zhang
authors: Qing-Qing
authors: QQ
authors: Huang
authors: Tong
authors: T
authors: Liu
authors: Tong-Zeng
authors: TZ
authors: Hu
mesh_terms: D000777:Anesthetics / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D000818:Animals; D001933:Brain Stem / Q000166:cytology / Q000187:drug effects* / Q000502:physiology*; D005260:Female; D007530:Isoflurane / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D008297:Male; D009619:Nociceptors / Q000166:cytology / Q000187:drug effects*; D011650:Pulmonary Alveoli / Q000378:metabolism; D051381:Rats; D012018:Reflex / Q000187:drug effects*; D013116:Spinal Cord / Q000166:cytology / Q000187:drug effects* / Q000502:physiology*; D014835:Volatilization
chemical_list: D000777:Anesthetics; D007530:Isoflurane