title: Lymphohistiocytoid variant of malignant mesothelioma of the pleura: a series of 22 cases.
abstract: The lymphohistiocytoid variant of diffuse malignant mesothelioma is rare with very few cases described in the literature. It is characterized by mesothelial cells with a histiocytelike appearance and an associated dense lymphoid infiltrate. We studied clinicopathologic features and immunohistochemical patterns of a series of 22 cases. The histiocytelike cells had a mesothelial immunophenotype: AE1/AE3 (100%), calretinin (100%), CK5/6 (46%), and EMA (52%). The prominent lymphoid component showed a cytotoxic T-cell immunophenotype. Prognosis was similar to that of a large series of epithelioid diffuse malignant mesotheliomas. Formely, it was classified within the sarcomatoid type. We suggest that it should be reclassified as an epithelioid variant because of its similar behavioural characteristics. There was no evidence of Epstein-Barr virus-related infection.
authors: Mesopath Group, ERI 3 Inserm, CHU Caen, Caen, France. galateausalle-f@chu-caen.fr
authors: Francoise
authors: F
authors: Galateau-Sallé
authors: Richard
authors: R
authors: Attanoos
authors: Allen R
authors: AR
authors: Gibbs
authors: Louise
authors: L
authors: Burke
authors: Philippe
authors: P
authors: Astoul
authors: Patrick
authors: P
authors: Rolland
authors: Anabelle Gilg Soit
authors: AG
authors: Ilg
authors: Jean Claude
authors: JC
authors: Pairon
authors: Patrick
authors: P
authors: Brochard
authors: Hugues
authors: H
authors: Begueret
authors: Jean Michel
authors: JM
authors: Vignaud
authors: Keith
authors: K
authors: Kerr
authors: Guy
authors: G
authors: Launoy
authors: Ellen
authors: E
authors: Imbernon
authors: Marcel
authors: M
authors: Goldberg
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism; D004848:Epithelium / Q000378:metabolism / Q000473:pathology; D005260:Female; D006644:Histiocytes / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D008297:Male; D008654:Mesothelioma / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D008875:Middle Aged; D010997:Pleural Neoplasms / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D011379:Prognosis; D015996:Survival Rate; D013602:T-Lymphocytes, Cytotoxic / Q000378:metabolism / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor