Synthesis and biological evaluation of nitric oxide-releasing derivatives of oleanolic acid as inhibitors of HepG2 cell apoptosis.
A total of 106 nitric oxide-releasing derivatives of oleanolic acid were synthesized and their effects on the inhibition of anti-Fas-mediated HepG2 cell apoptosis were evaluated in vitro. Several compounds inhibited anti-Fas-mediated HepG2 cell apoptosis in a dose-dependent manner. Within this series of compounds, 8b is the most potent inhibitor. The development of new NO-releasing derivatives of oleanolic acid may aid in the design of NO-based medicines for the intervention of human liver inflammatory diseases.
Chen
Li
L
Center of Drug Discovery, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, PR China.
Zhang
Yihua
Y
Kong
Xiangwen
X
Peng
Sixun
S
Tian
Jide
J
D017209:Apoptosis / Q000187:drug effects*; D002460:Cell Line; D022781:Hepatocytes / Q000187:drug effects*; D006801:Humans; D020030:Nitric Oxide Donors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D009828:Oleanolic Acid / Q000031:analogs & derivatives*; D011083:Polycyclic Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D019014:fas Receptor / Q000037:antagonists & inhibitors
D020030:Nitric Oxide Donors; D011083:Polycyclic Compounds; D019014:fas Receptor; D009828:Oleanolic Acid