[Positive ibopamine provocative test in normal-tension glaucoma suspects].
BACKGROUND
Ibopamine is an alpha-adrenergic agent and causes an elevation of intraocular pressure in eyes with increased outflow resistance. It has been proposed as a test substance for the detection of early ocular hydrodynamic disorders.


METHODS
A total of 64 normal-tension glaucoma suspect eyes without anti-hypertensive treatment were enrolled. A daily pressure curve was registered with measurements at 7:00 am, 8:00 am, 12:00 am, 17:00 pm using an applanation tonometer and a contour tonometer followed by instillation of ibopamine 2% in both eyes. Tonometry was performed every 15 minutes during the following hour. An IOP increase of > 2.0 mmHg was considered positive.


RESULTS
The positive test group showed a significant pressure increase from 18.04 to 22.06 mmHg. Ocular pulse amplitude increased from 2.96 to 3.97 mmHg and was positively correlated with the pressure. Intraocular pressure was unchanged in the negative test group. Central corneal thickness was not significantly different in the two groups (p = 0.32).


CONCLUSIONS
Ibopamine 2% eye drops have a positive pressure effect in 50% of suspected normal-tension glaucoma eyes and may differentiate between eyes with normal trabecular outflow capacity and eyes with increased resistance in the trabecular meshwork that are prone to pressure peaks and deterioration to glaucoma.
Kniestedt
C
C
Augenklinik, Kantonspital Winterthur, Winterthur, Schweiz. christoph.kniestedt@usz.ch
Romppainen
T
T
Gloor
B P
BP
Stürmer
J
J
D003846:Deoxyepinephrine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D005260:Female; D005901:Glaucoma / Q000175:diagnosis*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D009184:Mydriatics / Q000008:administration & dosage; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014065:Tonometry, Ocular / Q000379:methods*; D014665:Vasodilator Agents / Q000008:administration & dosage
D009184:Mydriatics; D014665:Vasodilator Agents; C023487:ibopamine; D003846:Deoxyepinephrine