The mechanisms of activation of normal human serum complement by Escherichia coli strains with K1 surface antigen.
Ten E. coli K1 strains isolated from the urine of children with urinary tract infections were sensitive to the bactericidal action of normal human serum (NHS). The role of the particular mechanisms of complement activation was determined in the process of killing these strains, showing variable sensitivity to the bactericidal action of NHS; three mechanisms of activation of human complement were observed. Important role of alternative pathway activation in the bactericidal action of NHS against E. coli K1 strains independent of the classical and lectin pathways was not established.
Bugla-Płoskońska
G
G
Institute of Genetics and Microbiology University of Wroclaw, Poland. gbploskonska@poczta.onet.pl
Cisowska
A
A
Karpińska
K
K
Jankowski
S
S
Doroszkiewicz
W
W
D000942:Antigens, Bacterial / Q000276:immunology*; D000954:Antigens, Surface / Q000276:immunology*; D001770:Blood Bactericidal Activity; D002648:Child; D003167:Complement Activation; D003170:Complement Pathway, Alternative; D003171:Complement Pathway, Classical; D037582:Complement Pathway, Mannose-Binding Lectin / Q000276:immunology; D004926:Escherichia coli / Q000276:immunology* / Q000302:isolation & purification; D004927:Escherichia coli Infections / Q000382:microbiology; D006801:Humans; D050296:Microbial Viability; D014552:Urinary Tract Infections / Q000382:microbiology
D000942:Antigens, Bacterial; D000954:Antigens, Surface