Clinical importance of HLA-DPB1 in haematopoietic cell transplantation.
There is increasing evidence for a significant effect of human leukocyte antigen (HLA)-DPB1 mismatching on complications following unrelated donor haematopoietic cell transplantation (HCT). In this analysis of 5930 patient/donor pairs, we found that a DPB1 mismatch predicted significantly for an increased risk of acute graft-vs-host disease [hazard ratio (HR): 1.33; P-value = <0.0001], while protecting against disease relapse (HR: 0.82, P-value = 0.01). These data support an immunogenic role for HLA-DPB1 in HCT and the need for pretransplant tissue typing at this locus.
Shaw
B E
BE
Department of Haematology, Nottingham City Hospital, Nottingham, UK. bshaw@doctors.org.uk
Gooley
T
T
Madrigal
J A
JA
Malkki
M
M
Marsh
S G E
SG
Petersdorf
E W
EW
D005260:Female; D006086:Graft vs Host Disease / Q000276:immunology; D006682:HLA-DP Antigens / Q000235:genetics / Q000276:immunology*; D059868:HLA-DP beta-Chains; D019337:Hematologic Neoplasms / Q000276:immunology / Q000628:therapy*; D018380:Hematopoietic Stem Cell Transplantation; D006650:Histocompatibility Testing / Q000379:methods*; D006801:Humans; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000209:etiology / Q000628:therapy; D011237:Predictive Value of Tests; D015996:Survival Rate
D006682:HLA-DP Antigens; D059868:HLA-DP beta-Chains; C071170:HLA-DPB1 antigen