Gingival crevicular fluid and serum leptin: their relationship to periodontal health and disease.
OBJECTIVE
Leptin is a pleiotrophic hormone produced by adipose tissue and it plays an important role in protection of the host from inflammation and infection. The purpose of this study is to determine the presence of leptin in gingival crevicular fluid (GCF) and serum samples and to find out their association, if any.


METHODS
Forty two subjects were selected based on their body mass index and were divided into three groups of 14 each; healthy (Group I), chronic gingivitis (Group II) and chronic periodontitis (Group III). GCF samples (by microcapillary pipettes) and serum samples (by venipuncture) were collected to estimate the levels of leptin using enzyme linked immunosorbent assay kit.


RESULTS
The highest mean leptin concentration in GCF was obtained for Group I (2658 pg/ml) and the least for Group III (1312 pg/ml). In contrast, the lowest serum leptin concentration was obtained for the Group I (8783 pg/ml), and the highest for Group III (12082 pg/ml). This suggests a negative correlation of GCF leptin concentration and a positive correlation of serum leptin concentration as the clinical attachment level progresses (p<0.05).


CONCLUSIONS
These results suggest that greater the periodontal destruction, lesser is the GCF leptin concentration and greater the serum leptin concentration.
Karthikeyan
B V
BV
Department of Periodontics, Government Dental College and Hospital, Bangalore, India. drkarthikeyanbv@rediffmail.com
Pradeep
A R
AR
D000328:Adult; D016022:Case-Control Studies; D002908:Chronic Disease; D005260:Female; D005881:Gingiva / Q000378:metabolism*; D005883:Gingival Crevicular Fluid / Q000737:chemistry*; D005888:Gingival Pocket / Q000097:blood / Q000378:metabolism; D005891:Gingivitis / Q000097:blood / Q000378:metabolism*; D006801:Humans; D020738:Leptin / Q000032:analysis* / Q000097:blood; D008297:Male; D017622:Periodontal Attachment Loss / Q000097:blood / Q000378:metabolism; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000097:blood / Q000378:metabolism; D010518:Periodontitis / Q000097:blood / Q000378:metabolism*
D020738:Leptin