Synthesis and biological validation of novel synthetic histone/protein methyltransferase inhibitors.
Mai
Antonello
A
Istituto Pasteur-Fondazione Cenci Bolognetti, Dipartimento di Studi Farmaceutici, Università degli Studi di Roma La Sapienza, P.le A. Moro 5, 00185 Roma, Italy. antonello.mai@uniroma1.it
Valente
Sergio
S
Cheng
Donghang
D
Perrone
Andrea
A
Ragno
Rino
R
Simeoni
Silvia
S
Sbardella
Gianluca
G
Brosch
Gerald
G
Nebbioso
Angela
A
Conte
Mariarosaria
M
Altucci
Lucia
L
Bedford
Mark T
MT
D000107:Acetylation; D002454:Cell Differentiation / Q000187:drug effects; D045744:Cell Line, Tumor; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006098:Granulocytes / Q000166:cytology / Q000187:drug effects; D000076983:Histone Methyltransferases; D011495:Histone-Lysine N-Methyltransferase / Q000037:antagonists & inhibitors*; D006801:Humans; D008745:Methylation; D015394:Molecular Structure; D010766:Phosphorylation; D011496:Protein Methyltransferases
D004791:Enzyme Inhibitors; D000076983:Histone Methyltransferases; D011496:Protein Methyltransferases; D011495:Histone-Lysine N-Methyltransferase