Ossification of the ligamentum flavum: diet and genetics.
Ossified ligamentum flavum (OLF) is being appreciated as an important cause of thoracic myeloradiculopathy. However, despite numerous epidemiological and basic science studies, the pathogenesis of OLF has not been conclusively established. Ossification and symptom development are significantly more frequent in the Japanese population, therefore supporting a genetic predilection for the disease process. We present an unusual case of OLF in a patient from a low-risk genetic background (Chinese), exposed in youth to a lifestyle and diet from a high-risk population (Japanese). Based on our case report, we support the view that dietary habits may constitute an independent risk factor for OLF and ossification of the posterior longitudinal ligament.
Mobbs
Ralph J
RJ
Prince of Wales Hospital, Peripheral Nerve Research Foundation, 3 Wansey Road, Randwick, New South Wales 2031, Australia. ralphmobbs@hotmail.com
Dvorak
Marcel
M
D004032:Diet / Q000009:adverse effects*; D005247:Feeding Behavior; D006801:Humans; D008019:Life Style; D017843:Ligamentum Flavum / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009999:Ossification, Heterotopic / Q000209:etiology* / Q000235:genetics*; D012307:Risk Factors