title: The microvascular thrombi of colonic tissue in ulcerative colitis.
abstract: Mucosal microvascular thrombi in rectal biopsies were observed in some ulcerative colitis (UC). Heparin may be effective in steroid resistant UC in some studies, however, the new results of meta-analysis demonstrated a non-significant effect of heparin in controlled clinical trials, differing markedly from observational studies. The objective of this study was to identify colonic microvascular thrombi in larger cases with UC, and analyse its possible risk factors: age, gender, histologic score, extent of lesions and operation or biopsy specimens, and assess the significance of microvascular thrombosis in patients with UC. The microvascular thrombi were identified by immunohistochemical staining with anti-CD61 monoclonal antibody and Martius scarlet blue (MSB) staining in 40 colonic tissue samples of UC (31 biopsy specimens and nine operated cases) and 12 cases of normal colon tissue from operated colonic carcinoma. Logistic regression analysis was used to assess the relationship of age, gender, degree of histology, origin of the specimens, extent of lesions and microvascular thrombi examined. Microvascular thrombi were positive in 14 of 40 UC cases, and none in the controls. The presence of microvascular thrombi was related to operation specimens with odds ratio 11.667, P=0.0179, it might be also related to histologic score (OR=1.350) and extent of lesions (OR=1.619). These results suggest that microvascular thrombosis may be one of the important pathogenesis in some UC, and that the effect of anticoagulant treatment still needs to be assessed.
authors: Department of Gastroenterology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, China. heguobin@tom.com
authors: Guobin
authors: G
authors: He
authors: Qin
authors: Q
authors: Ouyang
authors: Daiyun
authors: D
authors: Chen
authors: Fengyuan
authors: F
authors: Li
authors: Jingguo
authors: J
authors: Zhou
mesh_terms: D000328:Adult; D001391:Azo Compounds; D001706:Biopsy; D003093:Colitis, Ulcerative / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D003106:Colon / Q000098:blood supply*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D039661:Integrin beta3 / Q000276:immunology; D008297:Male; D008833:Microcirculation; D008875:Middle Aged; D011379:Prognosis; D012044:Regression Analysis; D012307:Risk Factors; D013927:Thrombosis / Q000209:etiology* / Q000378:metabolism / Q000473:pathology
chemical_list: D001391:Azo Compounds; D039661:Integrin beta3; C042643:Martius scarlet blue trichrome