title: Factors associated with lower Mini Mental State Examination scores in elderly Japanese diabetes mellitus patients.
abstract: Cognitive impairment in elderly diabetic patients has generated considerable interest recently; however, the mechanism of the impairment remains to be elucidated. In the current study, factors associated with cognitive dysfunction in old diabetic patients were explored. A Mini Mental State Examination (MMSE) was performed on 907 of 1173 registered elderly Japanese diabetic subjects. To characterize the clinical features of diabetes, we examined indices of glycemic control, lipid metabolism, blood pressure and complications. Single regression analysis adjusted for age showed that shorter height, higher GDS 15 scores, lower serum albumin, history of cerebrovascular disease, the existence of diabetic nephropathy, no smoking habit, no drinking habit, and no occupation were associated with lower MMSE scores. Multiple regression analysis demonstrated that age (odds ratio (OR)=1.079; 95% confidence interval (CI)=1.011-1.150), GDS 15 scores (OR=1.139; 95% CI=1.045-1.243), serum albumin (OR=0.336; 95% CI=0.174-0.745), and history of cerebrovascular disease (OR=3.011; 95% CI=1.578-5.748) were the variables significantly associated with having lower MMSE scores.
authors: Department of Geriatrics, Nagoya University Graduate School of Medicine, 65 Tsuruma-Cho, Showa-Ku, Nagoya, Aichi 466-8550, Japan. umegaki@med.nagoya-u.ac.jp
authors: Hiroyuki
authors: H
authors: Umegaki
authors: Satoshi
authors: S
authors: Iimuro
authors: Tetsuji
authors: T
authors: Kaneko
authors: Atsushi
authors: A
authors: Araki
authors: Takashi
authors: T
authors: Sakurai
authors: Yasuo
authors: Y
authors: Ohashi
authors: Akihisa
authors: A
authors: Iguchi
authors: Hideki
authors: H
authors: Ito
mesh_terms: D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D003072:Cognition Disorders / Q000175:diagnosis / Q000453:epidemiology*; D015897:Comorbidity; D003704:Dementia / Q000175:diagnosis / Q000453:epidemiology*; D003863:Depression / Q000175:diagnosis / Q000453:epidemiology*; D003920:Diabetes Mellitus / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D006801:Humans; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D008297:Male; D011569:Psychiatric Status Rating Scales; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors