[Apoptotic mechanisms induced in breast cancer cells by vinorelbine].
Vinorelbine (VNB) is one of new semi-synthesized vinka alkaloids developed in France, of which anti-tumor activity is susceptible mainly to non-small cell lung cancer and breast cancer. Moreover, its clinical efficacy has been noted from single-agent therapy or combination therapy with taxanes. It is assumed that VNB selectively acts on tubulin which elaborates microtubules, strands the cells at G 1 phase and interferes with the mitosis. VNB has unique anti-tumor activity as an antimicrotubule agent and is expected to be available for treatment of multi-drug resistant tumors. In this report, we demonstrate that VNB, as an antimicrotubule agent, induces apoptosis in breast cancer cell line, MX-1 via a mitochondrial pathway.
Nakajima
Hiroo
H
Dept. of Endocrine and Breast Surgery, Kyoto Prefectural University of Medicine.
Sakaguchi
Koichi
K
Mizuta
Naruhiko
N
Fujiwara
Ikuya
I
Hayakawa
Akemi
A
Magae
Junji
J
D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects* / Q000235:genetics; D001943:Breast Neoplasms / Q000473:pathology*; D020169:Caspases / Q000378:metabolism; D002470:Cell Survival / Q000187:drug effects; D005260:Female; D006801:Humans; D008928:Mitochondria / Q000378:metabolism / Q000502:physiology; D014407:Tumor Cells, Cultured; D014747:Vinblastine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000077235:Vinorelbine
D000972:Antineoplastic Agents, Phytogenic; D014747:Vinblastine; D020169:Caspases; D000077235:Vinorelbine