title: Consumption of mercury-contaminated rice induces oxidative stress and free radical aggravation in rats.
abstract: OBJECTIVE
  To study the oxidative stress induced by consumption of mercury-contaminated rice in rats, and to assess the possible public health risk of mercury contamination in Wanshan mining area.
  
  
  METHODS
  Sprague Dawley rats were fed the mercury-contaminated rice produced from Wanshan area for 90 days. The antioxidant status and the free radicals in rat serum were evaluated.
  
  
  RESULTS
  High mercury accumulation in organs of rats fed the mercury-contaminated rice confirmed the server pollution of mercury in Wanshan mining area. The intensity of electron spin resonance (ESR) signal increased by 87.38% in rats fed the rice from Wanshan compared with that in the control rats fed the rice from Shanghai, suggesting that chronic dietary consumption of rice from mercury mining area could induce an aggravation of free radicals. Feeding the mercury-contaminated rice was associated with significant decreases in the antioxidant enzymatic activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) and concentration of serum nitric oxide (NO), but it had no effect on serum nitric oxide synthase (NOS) activity. Feeding the mercury-contaminated rice raised the level of serum malonyldialdehyde (MDA), indicating the occurrence of oxidative stress.
  
  
  CONCLUSIONS
  The long-term dietary consumption of mercury-contaminated rice induces the aggravation of free radicals and exerts oxidative stress.
authors: School of Environmental Science and Engineering, Shanghai Jiaotong University, Shanghai, China.
authors: Xiu-Ling
authors: XL
authors: Jie
authors: Gui-Wen
authors: GW
authors: Jin
authors: Jin-Ping
authors: JP
authors: Cheng
authors: Wen-Hua
authors: WH
authors: Wang
authors: Jing
authors: J
authors: Lu
authors: Li-Ya
authors: LY
authors: Qu
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism; D002681:China; D004785:Environmental Pollutants / Q000032:analysis / Q000493:pharmacokinetics / Q000633:toxicity*; D005506:Food Contamination / Q000032:analysis; D005609:Free Radicals / Q000097:blood; D005979:Glutathione Peroxidase / Q000097:blood; D007220:Industrial Waste / Q000009:adverse effects; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008315:Malondialdehyde / Q000097:blood; D008628:Mercury / Q000032:analysis / Q000493:pharmacokinetics / Q000633:toxicity*; D008767:Methylmercury Compounds / Q000032:analysis / Q000493:pharmacokinetics / Q000633:toxicity*; D009569:Nitric Oxide / Q000097:blood; D019001:Nitric Oxide Synthase / Q000097:blood; D012275:Oryza; D018384:Oxidative Stress; D051381:Rats; D017207:Rats, Sprague-Dawley; D013482:Superoxide Dismutase / Q000097:blood
chemical_list: D004785:Environmental Pollutants; D005609:Free Radicals; D007220:Industrial Waste; D008767:Methylmercury Compounds; D009569:Nitric Oxide; D008315:Malondialdehyde; D005979:Glutathione Peroxidase; D019001:Nitric Oxide Synthase; D013482:Superoxide Dismutase; D008628:Mercury