[Effects of systemic corticosteroids on expression of Eotaxin in nasal polyps].
OBJECTIVE
To observe the effects of systemic corticosteroids on the expression of Eotaxin in nasal polyps.


METHODS
The SP immunohistochemical methods were applied to detected the expression of Eotaxin in nasal polyps before and after corticosteroids therapy. The optical density of positive cells in mucosal epithelia, vascular endothelia, inflammatory cells was measured by using HPIAS-2000 image-conduct system.


RESULTS
The expression of Eotaxin was positive in the cytoplasm of the mucosal epithelia,the inflammatory cells and the vascular endothelia in nasal polyps. The expression of Eotaxin was significantly reduced in the mucosal epithelia, the inflammatory cells and the vascular endothelia of nasal polyps after treated with corticosteroids compared with pre-treated.


CONCLUSIONS
Inhibiting the expression of Eotaxin in mucosal epithelia, inflammatory cells and vascular endothelia of nasal polyps, reducing recruitment and activation of eosinophil and relieving eosinophil inflammatory reaction in nasal polyps may be one of mechanisms of systemic corticosteroids therapy on the nasal polyps.
Yang
Wu
W
Department of Otolaryngology, the First People's Hospital of Xiangfan, Xiangfan, 441000, China. fadh318@yahoo.com.cn
Shi
Wei
W
Chen
Jinhui
J
Tao
Zezhang
Z
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D054413:Chemokine CCL11 / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000188:drug therapy* / Q000378:metabolism*
D000305:Adrenal Cortex Hormones; C515456:CCL11 protein, human; D054413:Chemokine CCL11