Bile acids as constituents for dental composites: in vitro cytotoxicity of (meth)acrylate and other ester derivatives of bile acids.
Methacrylic derivatives of bile acids have been synthesized for use as monomers in dental composites. Polymeric dental materials are known to leach cytotoxic unreacted monomers and degradation products. In this study, the in vitro cytotoxicity of bile acids and their derivatives towards 3T3 fibroblasts has been evaluated by colorimetric MTT assay and compared with that of the common dental monomers BisGMA, UDMA and TEGDMA. In general, the bile acids and their derivatives induced mitochondrial dysfunction at similar or higher concentrations than the commercial dental monomers. Certain monomers did not influence MTT response over their entire range of solubility.
Gauthier
Marc A
MA
Department of Chemistry, Université de Montréal, Montreal, Quebec, Canada.
Simard
Pierre
P
Zhang
Zhao
Z
Zhu
X X
XX
D016475:3T3 Cells; D000818:Animals; D001647:Bile Acids and Salts / Q000737:chemistry*; D003764:Dental Materials / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D005347:Fibroblasts / Q000187:drug effects*; D008422:Materials Testing; D008689:Methacrylates / Q000737:chemistry / Q000633:toxicity*; D051379:Mice; D015394:Molecular Structure
D001647:Bile Acids and Salts; D003764:Dental Materials; D008689:Methacrylates