Time-dependent postsynaptic AMPA GluR1 receptor recruitment in the cingulate synaptic potentiation.
The anterior cingulate cortex (ACC) is critical for brain functions including learning, memory, fear and pain. Long-term synaptic potentiation (LTP), a cellular model for learning and memory, has been reported in the ACC neurons. Unlike LTP in the hippocampus and amygdala, two key structures for memory and fear, little is known about the synaptic mechanism for the expression of LTP in the ACC. Here we use whole-cell patch clamp recordings to demonstrate that cingulate LTP requires the functional recruitment of GluR1 AMPA receptors; and such events are rapid and completed within 5-10 min after LTP induction. Our results demonstrate that the GluR1 subunit is essential for synaptic plasticity in the ACC and may play critical roles under physiological and pathological conditions.
Toyoda
Hiroki
H
Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada M5S 1A8.
Wu
Long-Jun
LJ
Zhao
Ming-Gao
MG
Xu
Hui
H
Zhuo
Min
M
D000818:Animals; D002118:Calcium / Q000378:metabolism; D004307:Dose-Response Relationship, Radiation; D004558:Electric Stimulation / Q000379:methods; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D019706:Excitatory Postsynaptic Potentials / Q000187:drug effects / Q000528:radiation effects; D006179:Gyrus Cinguli / Q000166:cytology*; D066298:In Vitro Techniques; D017774:Long-Term Potentiation / Q000187:drug effects / Q000502:physiology* / Q000528:radiation effects; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009474:Neurons / Q000187:drug effects / Q000502:physiology* / Q000528:radiation effects; D018408:Patch-Clamp Techniques; D010455:Peptides / Q000494:pharmacology; D017434:Protein Structure, Tertiary / Q000502:physiology; D018091:Receptors, AMPA / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000502:physiology*; D013997:Time Factors
D002118:Calcium; D018691:Excitatory Amino Acid Antagonists; D010455:Peptides; D018091:Receptors, AMPA