Lack of association between pseudoexfoliation syndrome and manganese superoxide dismutase polymorphism.
OBJECTIVE
The aim of this clinical study was to investigate the possible association between manganese superoxide dismutase (Mn-SOD) enzyme polymorphism in the mitochondrial targeting sequence and pseudoexfoliation syndrome.


METHODS
Ala (GTT) or Val (GCT) polymorphism in the signal peptide of Mn-SOD gene was evaluated using a primer pair to amplify a 107-bp fragment followed by digestion with restriction enzyme NgoM IV.


RESULTS
The frequencies of Ala-9 and Val-9 variants and genotypes of Mn-SOD were similar in the controls and pseudoexfoliation syndrome patients.


CONCLUSIONS
These results suggest no major modifying role for the Mn-SOD gene polymorphism in patients with pseudoexfoliation syndrome.
Yuce
Huseyin
H
Department of Medical Biology and Genetics, Firat University Medical Faculty, Elazig, Turkey. hyuce@firat.edu.tr
Hepsen
Ibrahim F
IF
Tekedereli
Ibrahim
I
Keskin
Ugurcan
U
Elyas
Halit
H
Akyol
Omer
O
D000328:Adult; D000409:Alanine; D017889:Exfoliation Syndrome / Q000201:enzymology* / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D013482:Superoxide Dismutase / Q000235:genetics*; D014633:Valine
D013482:Superoxide Dismutase; D014633:Valine; D000409:Alanine