title: ATP-induced relaxation of porcine retinal arterioles depends on the perivascular retinal tissue and acts via an adenosine receptor.
abstract: OBJECTIVE
  Purinergic compounds and cyclooxygenase inhibitors are involved in the tone regulation of isolated retinal arterioles in vitro, but it is unknown whether the perivascular retinal tissue influences these effects.
  
  
  METHODS
  Adenosine-and ATP-induced vasodilation of porcine retinal arterioles was studied in a wire myograph before and after removal of the perivascular tissue.
  
  
  RESULTS
  Both adenosine and ATP caused relaxation of the studied arterioles. This effect depended on the perivascular tissue and could be blocked by antagonists but was unaffected by ibuprofen.
  
  
  CONCLUSIONS
  The relaxation of porcine retinal arterioles induced by purinergic compounds is modulated by the perivascular retinal tissue.
authors: Department of Ophthalmology, Arhus University Hospital, Arhus, Denmark. khj@akhphd.au.dk
authors: Kim
authors: K
authors: Holmgaard
authors: Christian
authors: C
authors: Aalkjaer
authors: John D C
authors: JD
authors: Lambert
authors: Toke
authors: T
authors: Bek
mesh_terms: D000241:Adenosine / Q000494:pharmacology*; D000255:Adenosine Triphosphate / Q000494:pharmacology*; D000818:Animals; D001160:Arterioles / Q000187:drug effects; D066298:In Vitro Techniques; D009213:Myography; D018047:Receptors, Purinergic P1 / Q000502:physiology*; D012160:Retina / Q000502:physiology*; D012171:Retinal Vessels / Q000187:drug effects*; D013552:Swine; D014664:Vasodilation; D014665:Vasodilator Agents / Q000494:pharmacology*
chemical_list: D018047:Receptors, Purinergic P1; D014665:Vasodilator Agents; D000255:Adenosine Triphosphate; D000241:Adenosine