Quantitative assessment of regional left ventricular wall thickness and thickening using 16 multidetector-row computed tomography: comparison with cine magnetic resonance imaging.
OBJECTIVE
The purpose of this study was to investigate the feasibility of retrospective electrocardiography-gated multidetector-row computed tomography (MDCT) in the assessment left ventricular (LV) wall thickness and thickening and to test its validity compared to cine magnetic resonance imaging (MRI) as a standard of reference.


METHODS
We enrolled 19 patients who underwent both cardiac MDCT and cine MRI. End-diastolic wall thickness (EDWT) and end-systolic wall thickness (ESWT) were measured in 16 myocardial segments. Percent systolic wall thickening (%SWT) was generated from the EDWT and ESWT. Nondiagnostic myocardial segments were excluded. Correlation and agreement between MDCT and cine MRI were analyzed.


RESULTS
Segmental assessability values were 86.2% (262/304) and 92.1% (280/304) for MDCT and cine MRI, respectively. In assessable segments by both modalities (80.9%, 246/304), a significant correlation between MDCT and MRI was found (r = 0.89, 0.85, and 0.61, for EDWT, ESWT, and %SWT, respectively; all P < 0.05). Mean EDWT and ESWT values by MDCT were slightly lower than those by cine MRI (9.8 +/- 3.6 vs. 10.0 +/- 3.7 mm and 13.8 +/- 4.4 vs. 14.1 +/- 4.3 mm, respectively; both P < 0.01). Bland-Altman analysis revealed acceptable limits of agreement between MDCT and Cine MRI.


CONCLUSIONS
MDCT is a feasible method to assess regional LV wall thickness and systolic thickening.
Kanza
Rene E
RE
Department of Radiology, Ehime University Postgraduate School of Medicine, Shitsukawa, Toon 791-0295, Japan. tmochi@m.ehime-u.ac.jp
Higashino
Hiroshi
H
Kido
Teruhito
T
Kurata
Akira
A
Saito
Makoto
M
Sugawara
Yoshifumi
Y
Mochizuki
Teruhito
T
D000328:Adult; D000368:Aged; D016477:Artifacts; D004562:Electrocardiography; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000000981:diagnostic imaging / Q000473:pathology*; D007091:Image Processing, Computer-Assisted; D019028:Magnetic Resonance Imaging, Cine; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012189:Retrospective Studies; D018709:Statistics, Nonparametric; D014057:Tomography, X-Ray Computed / Q000379:methods*