Analysis of vaccine's schedules using models.
We present a further, yet important, step in applying Catania Mouse Model & simulator (SimTriplex) of immune system response to vaccination. In particular we show that, as immune response can induce toxicity, one can calibrate the vaccine administrations in such a way to avoid toxicity effects, keeping immunoprevention from cancer. This result increases the model's potential applications.
Pappalardo
F
F
Faculty of Pharmacy, University of Catania, Italy. francesco@dmi.unict.it
Motta
S
S
Lollini
P-L
PL
Mastriani
E
E
D000818:Animals; D019496:Cancer Vaccines / Q000008:administration & dosage* / Q000276:immunology*; D002278:Carcinoma in Situ / Q000276:immunology* / Q000517:prevention & control; D003198:Computer Simulation; D005260:Female; D007115:Immunization Schedule; D015674:Mammary Neoplasms, Animal / Q000276:immunology* / Q000517:prevention & control; D051379:Mice; D008807:Mice, Inbred BALB C; D008822:Mice, Transgenic; D018448:Models, Immunological; D014611:Vaccination / Q000379:methods*
D019496:Cancer Vaccines