Dextran-sulfate-adsorption of atherosclerotic lipoproteins from whole blood or separated plasma for lipid-apheresis--comparison of performance characteristics with DALI and Lipidfiltration.
For many years dextran sulfate adsorption (DSA) treatment of separated plasma has been an established technology for low-density lipoprotein (LDL)-elimination. Recently a system for the treatment of whole blood based on DSA was introduced into clinical practice. To further characterize DSA treatment of whole blood, the performance characteristics of both DSA modalities were compared at two investigational sites with two alternative LDL apheresis systems being already in routine clinical use. In prospective cross-over design, DSA whole blood treatment was compared with a whole blood polyacrylate LDL adsorption system (DALI) in one study group. DSA for plasma treatment was compared with Lipidfiltration in cross-over design in a second study group. In total, 12 patients on chronic LDL apheresis received 169 treatments. Six patients were treated twice with whole blood polyacrylate adsorption and twice with whole blood DSA. LDL-cholesterol (74.9-78.0%) and lipoprotein (a) (72.1-73.3%) were reduced by both with equal efficacy. DSA achieved a significantly higher reduction rate of fibrinogen. Another six patients were treated eight times with DSA plasma adsorption followed by 16 Lipidfiltration treatments. LDL-cholesterol (67.0-70.2%) and lipoprotein (a) (69.2-73.7%) were reduced by both with equal efficacy. Fibrinogen was eliminated more efficiently by Lipidfiltration (50.2 vs. 38.5%). DSA proved to be a safe and effective in both treatment modes, for plasma as well as for whole blood. At the discretion of the apheresis specialist, depending upon the status of national approval, DSA of whole blood complements the armamentarium of powerful modalities for extracorporeal elimination of atherosclerotic lipoproteins to meet specific individual, medical, or logistic needs.
Julius
Ulrich
U
Department for Internal Medicine III, University Hospital Dresden, Dresden, Germany.
Parhofer
Klaus G
KG
Heibges
Andreas
A
Kurz
Stefan
S
Klingel
Reinhard
R
Geiss
Hans-Christian
HC
D000180:Acrylic Resins / Q000737:chemistry; D050197:Atherosclerosis / Q000628:therapy*; D001781:Blood Component Removal / Q000379:methods*; D008078:Cholesterol, LDL / Q000097:blood / Q000302:isolation & purification*; D016264:Dextran Sulfate / Q000737:chemistry*; D005260:Female; D005340:Fibrinogen / Q000302:isolation & purification; D005374:Filtration / Q000379:methods; D006801:Humans; D008297:Male
D000180:Acrylic Resins; D008078:Cholesterol, LDL; C006903:carbopol 940; D005340:Fibrinogen; D016264:Dextran Sulfate