title: The saliva immunology mechanisms and periodontal status in HIV infected subjects.
abstract: OBJECTIVE
  The aim of this study was the evaluation of connection between parodontium determined by using GI and PBI indexes and specific immunity status and non-specific in HIV infected group and in control group.
  
  
  METHODS
  The study was carried out in the group of 37 patients infected with HIV. Mixed non-stimulated saliva was used for the study. Peroxidase activity was determined using the method by Mansson-Rahemtull. Lysozyme and A, G, M antibodies concentrations were determined with the use of radial immunodiffusion method. The concentration of lactoferrin was determined by using ELISA method. The clinical state of parodontium estimated by means of GI and PBI evaluating quality changes in the gum.
  
  
  RESULTS
  Deterioration of the immunological status of subjects was accompanied by the increase of the values of GI and PBI. The strong negative correlation between GI and PBI and the concentration of lactoferrin and positive activity of the peroxidase in the whole examined population was determined. In the infected group the correlation between the status of gingiva expressed by GI and concentration or activity of examined enzymes and immunoglobulins was not ascertained.
  
  
  CONCLUSIONS
  1. HIV infection is connected to worsening of paradontium status expressed by values of GI and PBI indexes. 2. Paradontium status correlated positively with immunological status of HIV positive subjects. 3. In HIV infected group, no connection between number of IgA, IgG, IgM, concentration of lysozyme, lactoferrin, activity of peroxidase and paradontium status was observed.
authors: Department of Conservative Dentistry, Medical University of Białystok, Poland.
authors: A
authors: A
authors: Klimiuk
authors: D
authors: D
authors: Waszkiel
authors: M
authors: M
authors: Choromańska
authors: A
authors: A
authors: Jankowska
authors: B
authors: B
authors: Zelazowska-Rutkowska
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D007781:Lactoferrin / Q000032:analysis; D008297:Male; D008875:Middle Aged; D009113:Muramidase / Q000032:analysis; D010510:Periodontal Diseases / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D010519:Periodontium / Q000276:immunology / Q000473:pathology; D009195:Peroxidase / Q000032:analysis; D012463:Saliva / Q000276:immunology*
chemical_list: D007136:Immunoglobulins; D009195:Peroxidase; D009113:Muramidase; D007781:Lactoferrin