title: Chemical modifications to improve the cellular uptake of oligonucleotides.
abstract: Specific control of gene expression by synthetic oligonucleotides (ON) is now widely used for target validation but clinical applications are limited by ON bioavailability. Moreover, most currently used strategies for physical and chemical delivery cannot be easily implemented in vivo. This article reviews new strategies which appear promising for ON delivery. The first part deals with ON chemical modifications aiming at improving cellular uptake as for instance the grafting of cationic groups on the ON backbone. The second part concerns ON conjugation to cell penetrating peptides.
authors: LCOBS, UMR 5625 CNRS, Université Montpellier 2, Place Eugene Bataillon, 34095 Montpellier cedex 5, France.
authors: Françoise
authors: F
authors: Debart
authors: Saïd
authors: S
authors: Abes
authors: Gaelle
authors: G
authors: Deglane
authors: Hong M
authors: HM
authors: Moulton
authors: Philippe
authors: P
authors: Clair
authors: Michael J
authors: MJ
authors: Gait
authors: Jean-Jacques
authors: JJ
authors: Vasseur
authors: Bernard
authors: B
authors: Lebleu
mesh_terms: D000588:Amines / Q000737:chemistry; D000818:Animals; D002463:Cell Membrane Permeability; D019791:Guanidine / Q000737:chemistry; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D009841:Oligonucleotides / Q000737:chemistry* / Q000378:metabolism*; D010455:Peptides / Q000737:chemistry / Q000378:metabolism
chemical_list: D000588:Amines; D009841:Oligonucleotides; D010455:Peptides; D019791:Guanidine