title: Cortico-subcortical distribution of microbleeds is different between hypertension and cerebral amyloid angiopathy.
abstract: BACKGROUND
  The cerebral distribution of microbleeds in cerebral amyloid angiopathy (CAA) is quite different from that in hypertension, i.e., microbleeds in central gray matters are frequently found in patients with advanced hypertension (aHT), but not in patients with CAA. Distributions within the cortico-subcortical (CSC) area have not been compared between the diseases, and remain poorly understood.
  
  
  OBJECTIVE
  We hypothesized that distributions of microbleeds differ in aHT and CAA even in the CSC area.
  
  
  METHODS
  Out of a consecutive series of patients with intracerebral hemorrhage who underwent brain MRI (n=181), we selected typical aHT and CAA patients by inclusion criteria. Microbleeds in the CSC area were localized according to anatomical divisions and vascular territories. Numbers of microbleeds in these areas were counted and statistically compared.
  
  
  RESULTS
  A total of 52 hemispheres (aHT, n=32; CAA, n=20) were analyzed. The number of CSC microbleeds was higher in the CAA group (47.6+/-56.8) than in the aHT group (17.4+/-27.4; p=0.01). The microbleeds showed a significant predilection for the temporo-occipital lobes in the aHT group, but for the parietal lobe in the CAA group. The most involved vascular territory was middle cerebral artery territory in both groups, but the lesion number in anterior cerebral artery territory was relatively high in the CAA group.
  
  
  CONCLUSIONS
  In this study sample, aHT and CAA show different topographical microbleeds distributions, even in the CSC area. Our results suggest that the CSC microbleeds may reflect different pathophysiological mechanisms between aHT and CAA.
authors: Department of Neurology, Seoul National University Hospital, 28 Yongon-dong, Jongno-gu, Seoul, 110-744, Republic of Korea.
authors: Seung-Hoon
authors: SH
authors: Lee
authors: Sung-Min
authors: SM
authors: Kim
authors: Nami
authors: N
authors: Kim
authors: Byung-Woo
authors: BW
authors: Yoon
authors: Jae-Kyu
authors: JK
authors: Roh
mesh_terms: D000368:Aged; D001921:Brain / Q000473:pathology*; D016657:Cerebral Amyloid Angiopathy / Q000150:complications* / Q000473:pathology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000473:pathology; D020300:Intracranial Hemorrhages / Q000209:etiology* / Q000473:pathology; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D018709:Statistics, Nonparametric