title: Kidney function and sarcopenia in the United States general population: NHANES III.
abstract: OBJECTIVE
  It is not known whether sarcopenia is associated with levels of kidney function in community-dwelling adults.
  
  
  METHODS
  Subjects were adult Third National Health and Nutrition Examination Survey participants in whom bioimpedance was performed (n = 13,770). Class I sarcopenia was defined as a skeletal mass index of 1-2 standard deviations below and class II sarcopenia as < 2 standard deviations below young adult values.
  
  
  RESULTS
  A monotonic association existed between increasing sarcopenia prevalence and declining glomerular filtration rate: > or = 90 ml/min/1.73 m2, 22.8% class I, 3.8% class II sarcopenia; 60-89 ml/min/1.73 m2, 33.6% class I, 5.3% class II sarcopenia, and < 60 ml/min/1.73 m2, 50.7% class I, 9.4% class II sarcopenia (p < 0.0001). This association dissipated when adjustment was made for older age and more comorbidity. Multivariate associations (p < 0.05) of sarcopenia and chronic kidney disease included: older age; low income-to-poverty ratio; overweight; lack of exercise; low carbohydrate, fat and protein intake; hypercalcemia; low 25-hydroxy-vitamin D3; higher diastolic blood pressure, and insulin resistance.
  
  
  CONCLUSIONS
  Sarcopenia is common in community-dwelling adults with chronic kidney disease. Although causality cannot be assumed, several associations may be susceptible to intervention.
authors: United States Renal Data System Coordinating Center, Minneapolis, Minn. 55404, USA. RFoley@usrds.org
authors: Robert N
authors: RN
authors: Foley
authors: Changchun
authors: C
authors: Wang
authors: Areef
authors: A
authors: Ishani
authors: Allan J
authors: AJ
authors: Collins
authors: Anne M
authors: AM
authors: Murray
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications*; D008297:Male; D008875:Middle Aged; D020966:Muscular Disorders, Atrophic / Q000453:epidemiology / Q000209:etiology*; D009749:Nutrition Surveys; D014481:United States / Q000453:epidemiology