Association between serum resistin and carotid intima media thickness in hypertension patients.
BACKGROUND
Resistin is an adipocytokine belonging to the family of cysteine rich secretory proteins. We sought to determine if a correlation between resistin levels and carotid atherosclerosis exists in hypertensive patients.


METHODS
This study consisted of 307 treated hypertensive patients. Subjects were grouped into tertiles according to their resistin level.


RESULTS
Carotid intima media thickness (IMT) was significantly highest in the third tertile. The first tertile had a mean carotid IMT and a mean of maximum carotid IMT of 0.63+/-0.08 and 0.81+/-0.10 mm, respectively. The 2nd tertile had measurements of 0.63+/-0.08 and 0.81+/-0.12 mm, and the 3rd tertile 0.67+/-0.12 and 0.86+/-0.11 for the same parameters. (p=0.002). Resistin levels were independently associated with the carotid IMT (mean carotid IMT: R(2)=0.159, p<0.001 and mean of maximum carotid IMT: R(2)=0.162, p<0.001) after controlling for age, gender, HDL cholesterol, triglyceride, LDL cholesterol, smoking and DM. The tertile level of resistin was significantly associated with (odds ratio=3.097, p=0.004) risk of coronary artery disease after controlling for age, gender, HDL cholesterol, triglyceride, LDL cholesterol, smoking, DM and carotid IMT.


CONCLUSIONS
Serum resistin is independently associated with increasing carotid IMT in treated hypertensive patients.
Shin
Hyun-Joon
HJ
Cardiology Division, Yonsei Cardiovascular Center, Yonsei University College of Medicine, SeodaemunGu 120-752, Seoul, Republic of Korea.
Park
Sungha
S
Yoon
Se-Jung
SJ
Choi
Dae Shik
DS
Cho
Deok-Kyu
DK
Kim
Jung-Sun
JS
Ko
Young-Guk
YG
Choi
Donghoon
D
Jang
Yangsoo
Y
Chung
Namsik
N
D054392:Adipokines / Q000097:blood; D000328:Adult; D000368:Aged; D002339:Carotid Arteries / Q000473:pathology*; D002340:Carotid Artery Diseases / Q000097:blood / Q000473:pathology*; D003324:Coronary Artery Disease / Q000473:pathology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000473:pathology* / Q000503:physiopathology; D007249:Inflammation; D008297:Male; D008875:Middle Aged; D052243:Resistin / Q000097:blood*; D012307:Risk Factors; D017539:Tunica Intima / Q000473:pathology*; D017540:Tunica Media / Q000473:pathology*
D054392:Adipokines; D052243:Resistin