title: Phosphorylation of Na+/Ca2+ exchanger in TAB-induced cardiac hypertrophy.
abstract: Both protein kinase Calpha-dependent Na+/Ca2+ exchanger1 (NCX1) phosphorylation and calcineurin activity are required for the depression of NCX activity observed in chronically phenylephrine (PE)-treated hypertrophic neonatal rat cardiomyocytes. In this study, we explored the possibility that the same changes occur in vivo hypertrophy. In the hypertrophic hearts of thoracic aortic-banded (TAB) mice, NCX1 phosphorylation increased significantly compared with control hearts. Furthermore, the TAB-induced cardiac hypertrophy was much less prominent in transgenic mice overexpressing an NCX1 mutant having defective phosphorylation sites. These data suggest that the phosphorylation status of NCX1 may play an important role in the pathogenesis of load-induced cardiac hypertrophy.
authors: Department of Molecular Physiology, National Cardiovascular Center Research Institute, Suita, Osaka 565-8565, Japan. ytanigu@md.okayama-u.ac.jp
authors: Yuki
authors: Y
authors: Katanosaka
authors: Bongju
authors: B
authors: Kim
authors: Shigeo
authors: S
authors: Wakabayashi
authors: Satoshi
authors: S
authors: Matsuoka
authors: Munekazu
authors: M
authors: Shigekawa
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001013:Aorta, Thoracic / Q000473:pathology; D006332:Cardiomegaly / Q000378:metabolism*; D003251:Constriction, Pathologic; D051379:Mice; D010766:Phosphorylation; D051571:Protein Kinase C-alpha / Q000378:metabolism; D019831:Sodium-Calcium Exchanger / Q000378:metabolism*
chemical_list: D019831:Sodium-Calcium Exchanger; D051571:Protein Kinase C-alpha