Conversion of flavodoxin from holoenzyme to apoprotein during growth phase changes in Helicobacter pylori.
The catabolic pathway for flavodoxin has yet to be clarified for any bacterial species. In this study, we found that the flavin mononucleotide in the flavodoxin of Helicobacter pylori is degraded to riboflavin via the phosphomonoesterase activity of class C acid phosphatase. The result is a conversion of holoflavodoxin to apoflavodoxin.
Shimomura
Hirofumi
H
Division of Bacteriology, Department of Infection and Immunity, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi 329-0498, Japan. shimo@jichi.ac.jp
Hayashi
Shunji
S
Yokota
Kenji
K
Oguma
Keiji
K
Hirai
Yoshikazu
Y
D001059:Apoproteins / Q000737:chemistry / Q000378:metabolism*; D001426:Bacterial Proteins / Q000737:chemistry / Q000378:metabolism; D005486:Flavin Mononucleotide / Q000737:chemistry / Q000378:metabolism; D005418:Flavodoxin / Q000737:chemistry / Q000378:metabolism*; D016480:Helicobacter pylori / Q000254:growth & development / Q000378:metabolism*; D020035:Holoenzymes / Q000737:chemistry / Q000378:metabolism*; D010766:Phosphorylation; D012256:Riboflavin / Q000737:chemistry / Q000378:metabolism; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
D001059:Apoproteins; D001426:Bacterial Proteins; D005418:Flavodoxin; D020035:Holoenzymes; C026932:apoflavodoxin; D005486:Flavin Mononucleotide; D012256:Riboflavin