Fibroblast growth factor (FGF)23 in patients with acromegaly.
Fibroblast growth factor (FGF)23 is a hormone that regulates serum phosphate and 1,25-dihydroxyvitamin D levels. Hyperphosphatemia is sometimes observed in patients with acromegaly while the detailed mechanism of this abnormal phosphate metabolism remains to be elucidated. We have measured FGF23 levels in 18 patients before and after the surgery for acromegaly. Serum GH, IGF-I and phosphate significantly decreased after the surgery. In addition, FGF23 also reduced by the surgery. These results indicate that deficient action of FGF23 is not the cause of deranged phosphate metabolism in patients with acromegaly.
Ito
Nobuaki
N
Division of Nephrology & Endocrinology, Department of Medicine, The University of Tokyo Hospital, Japan.
Fukumoto
Seiji
S
Taguchi
Manabu
M
Takeshita
Akira
A
Takeuchi
Yasuhiro
Y
Yamada
Shozo
S
Fujita
Toshiro
T
D000172:Acromegaly / Q000097:blood* / Q000601:surgery; D000328:Adult; D000368:Aged; D005260:Female; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000097:blood*; D019382:Human Growth Hormone / Q000097:blood; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000032:analysis; D008297:Male; D008875:Middle Aged; D010710:Phosphates / Q000097:blood / Q000378:metabolism
C000717427:FGF23 protein, human; D010710:Phosphates; D019382:Human Growth Hormone; D005346:Fibroblast Growth Factors; D007334:Insulin-Like Growth Factor I; D000089703:Fibroblast Growth Factor-23