Retroviral activation of the mir-106a microRNA cistron in T lymphoma.
Retroviral insertion into a host genome is a powerful tool not only for the discovery of cancer genes, but also for the discovery of potential oncogenic noncoding RNAs. In a large-scale mouse T lymphocyte tumor screen we found a high density of integrations upstream of the mir-106a microRNA cistron. In tumors containing an integration, the primary transcript encoding the mir-106a cistron was overexpressed five to 20-fold compared with that of control tumors; concomitantly, the mature mir-106a and mir-363 microRNAs were highly overexpressed as well. These findings suggest the mir-106a cistron plays an important role in T cell tumorigenesis.
Lum
Amy M
AM
Picobella, L.L.C., Burlingame, CA, 94010, USA. amy@picobella.com
Wang
Bruce B
BB
Li
Lauri
L
Channa
Namitha
N
Bartha
Gabor
G
Wabl
Matthias
M
D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D005786:Gene Expression Regulation; D005796:Genes / Q000235:genetics*; D016399:Lymphoma, T-Cell / Q000235:genetics* / Q000821:virology; D008297:Male; D051379:Mice; D035683:MicroRNAs / Q000235:genetics*; D011995:Recombination, Genetic; D012190:Retroviridae / Q000502:physiology*; D014158:Transcription, Genetic
D035683:MicroRNAs