Pharmacologic modulation of sebaceous gland activity: mechanisms and clinical applications.
Acne vulgaris is a common skin condition seen by physicians. It primarily affects adolescents, but can continue into adulthood. A key factor in the pathogenesis of acne is sebum production. Typical therapy includes combinations of topical retinoids and antimicrobials for mild acne, with the addition of oral antibiotics for moderate to severe disease. In the most recalcitrant cases or for nodulocystic acne, oral retinoids are indicated. In women who fail to respond to conventional treatment, hormonal therapy is often used adjunctively. Only isotretinoin and hormonal therapy improve acne via their action on the sebaceous glands. This article focuses on the mechanisms by which these treatment modalities act on the sebaceous glands and their clinical use in the practice of medicine.
Clarke
Shari B
SB
The Department of Dermatology, The Pennsylvania State University College of Medicine, P.O. Box 850, Hershey, PA 17033, USA.
Nelson
Amanda M
AM
George
Rosalyn E
RE
Thiboutot
Diane M
DM
D000152:Acne Vulgaris / Q000188:drug therapy* / Q000503:physiopathology; D000726:Androgen Antagonists / Q000627:therapeutic use*; D000728:Androgens / Q000502:physiology; D006801:Humans; D015474:Isotretinoin / Q000627:therapeutic use*; D012625:Sebaceous Gland Diseases / Q000188:drug therapy* / Q000503:physiopathology; D012627:Sebaceous Glands / Q000187:drug effects* / Q000503:physiopathology
D000726:Androgen Antagonists; D000728:Androgens; D015474:Isotretinoin