title: Central atrial natriuretic peptide in dehydration.
abstract: To test the effect of dehydration on brain atrial natriuretic peptide (ANP) concentrations in areas important to salt appetite, water balance and cardiovascular regulation, we subjected rats to dehydration and rehydration and measured ANP concentration in 18 brain areas, as well as all relevant peripheral parameters. Water deprivation decreased body weight, blood pressure, urine volume, and plasma ANP, while it increased urine and plasma osmolality, angiotensin II, and vasopressin. ANP greatly increased in 17 and 18 brain areas (all cut cerebral cortex) by 24 h. Rehydration for 12 h corrected all changes evoked by dehydration, including elevated ANP levels in brain. We conclude that chronic dehydration results in increased ANP in brain areas important to salt appetite and water balance. These results support a role for ANP as a neuroregulatory substance that participates in salt and water balance.
authors: KfH Nierenzentrum, Hans-Brandmann-Weg 1, D-97080 Würzburg, Germany.
authors: Udo
authors: U
authors: Bahner
authors: Helmut
authors: H
authors: Geiger
authors: Miklós
authors: M
authors: Palkovits
authors: Zsolt
authors: Z
authors: Lenkei
authors: Friedrich C
authors: FC
authors: Luft
authors: August
authors: A
authors: Heidland
mesh_terms: D000804:Angiotensin II / Q000097:blood; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000097:blood / Q000378:metabolism*; D001794:Blood Pressure; D001835:Body Weight; D001921:Brain / Q000378:metabolism; D002540:Cerebral Cortex / Q000378:metabolism*; D003681:Dehydration / Q000378:metabolism*; D008297:Male; D009994:Osmolar Concentration; D051381:Rats; D017208:Rats, Wistar; D013894:Thirst; D013997:Time Factors; D014556:Urine; D014667:Vasopressins / Q000097:blood; D014882:Water-Electrolyte Balance
chemical_list: D014667:Vasopressins; D000804:Angiotensin II; D009320:Atrial Natriuretic Factor