Predictive genetic variants for venous thrombosis: what's new?
Various pathways lead to the development of venous thrombosis. Risk factors are common and can be genetic or acquired. Since the identification of factor V Leiden and prothrombin 20210 G-->A, the field of genetic epidemiology has developed rapidly and many new genetic variants have been described in the past decade. However, the association with venous thrombosis is often unclear and conflicting results have been reported in various studies. The aim of this review is to describe these candidate predictors of venous thrombosis and to put these in perspective.
Bezemer
Irene D
ID
Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.
Rosendaal
Frits R
FR
D000017:ABO Blood-Group System / Q000097:blood; D001779:Blood Coagulation Factors / Q000037:antagonists & inhibitors / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D020641:Polymorphism, Single Nucleotide / Q000502:physiology*; D020246:Venous Thrombosis / Q000235:genetics*
D000017:ABO Blood-Group System; D001779:Blood Coagulation Factors