Mimicking methylated histones.
Histones with specific patterns of lysine methylation help to define how their associated DNA is used. A recent semisynthetic strategy for generating histone proteins that contain methyl-lysine analogues at specific sites will provide researchers with the materials to further elucidate the role of these modifications.
Shogren-Knaak
Michael A
MA
Department of Biochemistry, Biophysics, and Molecular Biology, Iowa State University, 4214 Molecular Biology Building, Ames, Iowa 50011, USA. knaak@iastate.edu
D000595:Amino Acid Sequence; D006657:Histones / Q000502:physiology*; D008239:Lysine / Q000378:metabolism*; D008745:Methylation
D006657:Histones; D008239:Lysine