title: Conformational control of HCl co-transporter: imidazole functionalised isophthalamide vs. 2,6-dicarboxamidopyridine.
abstract: Replacement of the central isophthalamide core in a synthetic HCl receptor, with a 2,6-dicarboxamidopyridine, leads to a more preorganised molecular structure that exhibits higher chloride affinity and membrane transport flux.
authors: School of Chemistry, University of Southampton, Southampton, UK SO17 1BJ. philip.gale@soton.ac.uk
authors: Philip A
authors: PA
authors: Gale
authors: Joachim
authors: J
authors: Garric
authors: Mark E
authors: ME
authors: Light
authors: Beth A
authors: BA
authors: McNally
authors: Bradley D
authors: BD
authors: Smith
mesh_terms: D000577:Amides / Q000737:chemistry*; D006851:Hydrochloric Acid / Q000737:chemistry*; D007093:Imidazoles / Q000737:chemistry*; D008968:Molecular Conformation; D010795:Phthalic Acids / Q000737:chemistry*; D011522:Protons; D011725:Pyridines / Q000737:chemistry*
chemical_list: D000577:Amides; D007093:Imidazoles; D010795:Phthalic Acids; D011522:Protons; D011725:Pyridines; C029899:imidazole; D006851:Hydrochloric Acid