title: The excess in 2-5 mm follicles seen at ovarian ultrasonography is tightly associated to the follicular arrest of the polycystic ovary syndrome.
abstract: BACKGROUND
  We previously hypothesized that the excess of 2-5 mm follicles seen at ovarian ultrasonography might be involved in the follicular arrest (FA) of polycystic ovary syndrome (PCOS), independently from the main putative contributors of FA, namely hyperandrogenism and hyperinsulinism.
  
  
  METHODS
  A multivariate statistical analysis was applied retrospectively to clinical, biological and ultrasound data that were consecutively collected during 5 years in 457 patients with polycystic ovaries and in 188 age-matched non-hyperandrogenic and regularly cycling controls without PCO at ultrasound.
  
  
  RESULTS
  Stepwise discriminant analysis indicated that in PCOS the 2-5 mm follicle number (FN) gave the strongest correlation to severity of the FA, followed by age and then by fasting insulin level. The other variables [waist circumference (WC), 6-9 mm FN, serum testosterone, FSH, LH and ovarian area] were rejected by the analysis. Multiple linear regression indicated a significant and independent negative relationship between the 2-5 and 6-9 mm FN in the PCOS (r = - 0.186, P < 0.01) and control groups (r = - 0.281, P < 0.01). In PCOS only, the 6-9 mm FN was negatively and independently related to the WC (r = - 0.108, P < 0.05).
  
  
  CONCLUSIONS
  The size of the 2-5 mm follicle pool is an independent and important contributor to the FA of PCOS. This result could be explained by an exaggerated physiological inhibitory effect from this pool on the terminal follicle growth. The metabolic derangement of PCOS that also contributes to the FA would act through a different mechanism.
authors: Department of Endocrine Gynaecology and Reproductive Medicine, Hôpital Jeanne de Flandre, C.H.R.U., 59037 Lille, France. ddewailly@chru-lille.fr
authors: Didier
authors: D
authors: Dewailly
authors: Sophie
authors: S
authors: Catteau-Jonard
authors: Anne-Céline
authors: AC
authors: Reyss
authors: Catherine
authors: C
authors: Maunoury-Lefebvre
authors: Edouard
authors: E
authors: Poncelet
authors: Pascal
authors: P
authors: Pigny
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D017588:Hyperandrogenism / Q000473:pathology; D006946:Hyperinsulinism / Q000473:pathology; D007328:Insulin / Q000097:blood; D007986:Luteinizing Hormone / Q000097:blood; D006080:Ovarian Follicle / Q000000981:diagnostic imaging / Q000473:pathology*; D010053:Ovary / Q000000981:diagnostic imaging / Q000473:pathology*; D011085:Polycystic Ovary Syndrome / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology*; D012189:Retrospective Studies; D013739:Testosterone / Q000097:blood; D014463:Ultrasonography
chemical_list: D007328:Insulin; D013739:Testosterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone