Simultaneous occurrence of medullary carcinoma and papillary microcarcinoma of thyroid in a patient with MEN 2A syndrome. report of a case.
We report a case of simultaneous multifocal medullary carcinoma and papillary microcarcinoma in a patient with several distinctive features of MEN 2A. The patient underwent total thyroidectomy and central lymph node dissection. The extreme rarity and pathological features of this occurrence are discussed. There is no known common cause of these 2 different tumor types; it may be a stochastic exception. However, several other possibilities such as a common precursor cell or a common tumorigenic stimulus offer interesting perspectives for speculation.
Giacomelli
Laura
L
Department of Surgical Sciences, Policlinico Umberto I, University of Rome La Sapienza, Rome, Italy.
Guerriero
Gabriella
G
Falvo
Laura
L
Altomare
Vittorio
V
Chiesa
Carlo
C
Ferri
Simone
S
Stio
Francesco
F
D018276:Carcinoma, Medullary / Q000209:etiology / Q000473:pathology* / Q000503:physiopathology; D002291:Carcinoma, Papillary / Q000209:etiology / Q000473:pathology* / Q000503:physiopathology; D005260:Female; D006042:Goiter / Q000150:complications / Q000188:drug therapy; D006801:Humans; D018813:Multiple Endocrine Neoplasia Type 2a / Q000150:complications*; D009378:Neoplasms, Multiple Primary / Q000209:etiology / Q000473:pathology* / Q000503:physiopathology; D013964:Thyroid Neoplasms / Q000209:etiology / Q000473:pathology* / Q000503:physiopathology; D013974:Thyroxine / Q000627:therapeutic use
D013974:Thyroxine