Frequent but nonrandom expression of myeloid markers on de novo childhood acute lymphoblastic leukemia.
The expression of the myeloid markers CD13, CD33, and CD15 in two hundred and eighty-three cases of de novo childhood acute lymphoblastic leukemia (ALL) is examined. The expression of at least one marker is a frequent event which is noted in 64% and 74% of B- and T-lineage ALL cases, respectively. Certain patterns of myeloid antigen expression can be recognized including: no expression of CD13, CD33, and CD15 in mature B-ALL, significantly higher levels of CD13 and CD33 and significantly lower levels of CD15 in TEL-AML1-positive B cell precursor ALL, no expression of CD13 and CD33 in E2A-PBX1-positive B cell precursor ALL cases and common T-ALL (double positive for CD4 and CD8), and no expression of CD13 in MLL-AF4-positive B cell precursor ALL cases. Although the numbers in some ALL subtypes are small, these patterns are consistent with nonrandom expression of myeloid markers in de novo childhood ALL.
Abdelhaleem
Mohamed
M
Division of Haematopathology, Department of Paediatric Laboratory Medicine, Rm 3691, Atrium, Hospital for Sick Children, 555 University Avenue, Toronto, ON, Canada M5G 1X8. mohamed.abdelhaleem@sickkids.ca
D015703:Antigens, CD / Q000378:metabolism; D015214:Antigens, Differentiation, Myelomonocytic / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000378:metabolism*; D002051:Burkitt Lymphoma / Q000378:metabolism / Q000473:pathology; D018826:CD13 Antigens / Q000378:metabolism; D002454:Cell Differentiation; D002648:Child; D050676:Core Binding Factor Alpha 2 Subunit / Q000378:metabolism; D018398:Homeodomain Proteins / Q000378:metabolism; D006801:Humans; D016256:Lewis X Antigen / Q000378:metabolism; D022423:Myeloid Cells / Q000378:metabolism*; D015514:Oncogene Proteins, Fusion / Q000378:metabolism; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000378:metabolism* / Q000473:pathology; D063268:Sialic Acid Binding Ig-like Lectin 3; D000097764:ETS Translocation Variant 6 Protein
D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D014408:Biomarkers, Tumor; D018826:CD13 Antigens; D050676:Core Binding Factor Alpha 2 Subunit; D018398:Homeodomain Proteins; D016256:Lewis X Antigen; D015514:Oncogene Proteins, Fusion; D063268:Sialic Acid Binding Ig-like Lectin 3; C571163:CD33 protein, human; C102421:TEL-AML1 fusion protein; D000097764:ETS Translocation Variant 6 Protein; C089847:E2A-Pbx1 fusion protein