title: Particle size of LDL is affected by the National Cholesterol Education Program (NCEP) step II diet in dyslipidaemic adolescents.
abstract: The objective was to determine the effects of the National Cholesterol Education Program (NCEP) step II diet on LDL and HDL particle size in dyslipidaemic adolescents. Forty-four dyslipidaemic adolescents, aged 10-18 years, participated in this case-control study. The control diet was a diet similar to what most Tehranian adolescents eat. NCEP step II diet was a diet with 30 % of energy as total fat, less than 7 % saturated fat, less than 200 mg cholesterol/d, less than 15 % of energy as MUFA and less than 10 % as PUFA. Lipoprotein particle size was the major outcome variable, which was measured after 3 months of intervention. Comparison was made by the repeated measurement ANOVA. The mean BMI was 26.3 (sd 4.2) kg/m2. There were no significant changes in weight or physical activity in the two groups during the study. The NCEP diet resulted in higher reduction in total cholesterol ( - 13 (sd 4) v. - 2 (sd 0.3) mg/dl, P < 0.001) and LDL ( - 9 (sd 2) v. 3 (sd 0.6) mg/dl, P < 0.01), and higher increase in size of the LDL (1.7 (sd 0.4) v. 0.1 (sd 0.4) nanometer, P < 0.001). HDL particle size did not change significantly. NCEP step II diet had a favourable effect on the LDL particle size. The related mechanism needs to be studied in future experimental designs.
authors: Endocrine Research Center, Shaheed Beheshti University of Medical Sciences, Tehran, Iran.
authors: Leila
authors: L
authors: Azadbakht
authors: Parvin
authors: P
authors: Mirmiran
authors: Mehdi
authors: M
authors: Hedayati
authors: Ahmad
authors: A
authors: Esmaillzadeh
authors: Nilufar
authors: N
authors: Shiva
authors: Fereidoun
authors: F
authors: Azizi
mesh_terms: D000293:Adolescent; D000704:Analysis of Variance; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D002648:Child; D002784:Cholesterol / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D004041:Dietary Fats / Q000008:administration & dosage; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood* / Q000178:diet therapy / Q000453:epidemiology; D007492:Iran / Q000453:epidemiology; D008075:Lipoproteins, HDL / Q000097:blood*; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D010316:Particle Size; D010353:Patient Education as Topic / Q000379:methods*; D015995:Prevalence
chemical_list: D008078:Cholesterol, LDL; D004041:Dietary Fats; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D002784:Cholesterol