Continuous infusion of methylprednisolone via paediatric parenteral nutrition: a pharmacokinetic animal study.
OBJECTIVE
The aim of our study consisted to measure the pharmacokinetic parameters of methylprednisolone administered in a continuous infusion of a paediatric parenteral nutrition mixture for 24h in the rabbit.


METHODS
Fourteen rabbits were split into two groups and assigned a different administration vehicle (all-in-one or two-in-one nutrition mixture). We used USC PACK* pharmacokinetics software to compare the influence of the composition of the paediatric parenteral nutritional solutions on the values of the pharmacokinetic parameters of methylprednisolone.


RESULTS
Neither the steady-state plasma concentrations of methylprednisolone hemisuccinate nor the values of the pharmacokinetic parameters of methylprednisolone differed significantly when administered in two-in-one or all-in-one nutrition mixtures.


CONCLUSIONS
The composition of the nutritional medium had no discernable effect on the bioavailability of methylprednisolone. Neither the speed at which the steady-state plasma concentration was reached, nor the values of the pharmacokinetic parameters of methylprednisolone were significantly modified.
Gellis
Christophe
C
Laboratoire de Pharmacie Clinique et Biotechnique, EA2416, Faculté de Médecine-Pharmacie, 28 Place Henri-Dunant, 63000, Clermont-Ferrand, France.
Sautou-Miranda
Valérie
V
Bleyzac
Nathalie
N
Jarrige
Jean-François
JF
Minet-Quinard
Régine
R
Chopineau
Jean
J
D000818:Animals; D001682:Biological Availability; D002853:Chromatography, Liquid / Q000379:methods; D004195:Disease Models, Animal; D004338:Drug Combinations; D005938:Glucocorticoids / Q000493:pharmacokinetics*; D006801:Humans; D007263:Infusions, Parenteral / Q000379:methods; D008297:Male; D008657:Metabolic Clearance Rate; D008776:Methylprednisolone Hemisuccinate / Q000493:pharmacokinetics*; D010288:Parenteral Nutrition / Q000009:adverse effects / Q000379:methods*; D011817:Rabbits; D011897:Random Allocation; D013047:Specific Pathogen-Free Organisms
D004338:Drug Combinations; D005938:Glucocorticoids; D008776:Methylprednisolone Hemisuccinate