Shedding of Escherichia coli O157:H7 in calves is reduced by prior colonization with the homologous strain.
Enterohemorrhagic Escherichia coli O157:H7 has a natural reservoir in the intestinal tracts of cattle. Colonization is asymptomatic and transient, but it is not clear if protective immunity is induced. This study demonstrates that prior colonization induces humoral immune responses to bacterial antigens and reduces bacterial shedding after experimental challenge with the homologous strain.
Naylor
Stuart W
SW
Animal Health Group, Scottish Agricultural College, Edinburgh EH9 3JG, UK. stuart.naylor@sac.ac.uk
Flockhart
Allen
A
Nart
Pablo
P
Smith
David G E
DG
Huntley
John
J
Gally
David L
DL
Low
J Christopher
JC
D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood; D002417:Cattle; D002418:Cattle Diseases / Q000276:immunology / Q000382:microbiology*; D004797:Enzyme-Linked Immunosorbent Assay; D004927:Escherichia coli Infections / Q000276:immunology / Q000382:microbiology / Q000662:veterinary*; D019453:Escherichia coli O157 / Q000276:immunology* / Q000302:isolation & purification*; D005243:Feces / Q000382:microbiology*; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood
D000907:Antibodies, Bacterial; D007070:Immunoglobulin A; D007074:Immunoglobulin G