[Difference in the CD4+T lymphocytes activation between long term non-progressors and typical progressors of HIV-1 infected patients].
OBJECTIVE
To investigate the difference in the CD4+T lymphocytes activation between long term non progressors (LTNP) and typical progressors (TP) of HIV-1 infected patients.


METHODS
Twenty-four HIV-1 infected patients and 15 heathy control adults were tested and flow cytometry was used to detect the activation marker CD38 and CD4 count in blood samples taken from the patients and control. bDNA method was used to test the virus load in the plasma of patients.


RESULTS
The activation of CD4+T cells was positively correlated with virus load and negatively correlated with CD4 counts. Compared with normal controls, the activation of CD4+T cells was obviously increased in TP patients but not obviously changed in LTNP patients.


CONCLUSIONS
Compared with healthy controls, the activation of CD4+T cells in LTNP did not obviously increase. This maybe partially accounts for LTNP patients keeping a good state for a long time.
Jiao
Yan-mei
YM
Beijing You-an Hospital Affiliated to Capital University of Medical Sciences, Beijing 100054, China.
Fu
Jun-liang
JL
Zhang
Zheng
Z
Zhang
Hui
H
Jin
Lei
L
Zhou
Chun-bao
CB
Fu
Bao-yun
BY
Wang
Fu-sheng
FS
Wu
Hao
H
D051997:ADP-ribosyl Cyclase 1 / Q000032:analysis; D000328:Adult; D018791:CD4 Lymphocyte Count; D015496:CD4-Positive T-Lymphocytes / Q000166:cytology / Q000276:immunology*; D005260:Female; D005434:Flow Cytometry; D015658:HIV Infections / Q000097:blood / Q000276:immunology* / Q000821:virology; D015497:HIV-1 / Q000235:genetics / Q000502:physiology*; D054884:Host-Pathogen Interactions; D006801:Humans; D008213:Lymphocyte Activation / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D012367:RNA, Viral / Q000097:blood; D013997:Time Factors; D019562:Viral Load; D055815:Young Adult
D012367:RNA, Viral; D051997:ADP-ribosyl Cyclase 1