Urticaria and angio-oedema due to ziprasidone.
Antipsychotic medications are commonLy associated with adverse cutaneous reactions (ACRs) in approximately 5% of patients. Angio-oedema accompanying urticaria is one of the most serious ACRs. The 36-year-old female patient who was diagnosed with ;Paranoid schizophrenia' 6 years ago, was commenced on ziprasidone 120 mg/day. On day 30 of the treatment, the patient presented urticarial papules and plaques all over the body and angio-oedema in the face. The patient was diagnosed as ;Urticaria + Angio-oedema'. The development of ACRs after the initation of ziprasidone monotherapy, disappearance of lesions after the discontinuation of this antipsychotic, and positive intradermal skin test all suggests a possible causal relationship between ACRs and ziprasidone. To our knowledge, this is the first reported case of urticaria and angio-oedema due to ziprasidone monotherapy. Ziprasidone is a valid and effective choice amongst antipsychotic medications, but this case calls for caution regarding ACRs at the time of prescribing.
Akkaya
Cengiz
C
Uludag University Medical Faculty, Psychiatry Department, Bursa, Turkey. cakkaya@uludag.edu.tr
Sarandol
Asli
A
Aydogan
Kenan
K
Kirli
Selcuk
S
D000328:Adult; D000799:Angioedema / Q000139:chemically induced* / Q000473:pathology; D014150:Antipsychotic Agents / Q000009:adverse effects*; D005260:Female; D006801:Humans; D010879:Piperazines / Q000009:adverse effects*; D012563:Schizophrenia, Paranoid / Q000188:drug therapy*; D013844:Thiazoles / Q000009:adverse effects*; D014581:Urticaria / Q000139:chemically induced* / Q000473:pathology
D014150:Antipsychotic Agents; D010879:Piperazines; D013844:Thiazoles; C092292:ziprasidone