title: Mitochondrial targeting of quinones: therapeutic implications.
abstract: Mitochondrial oxidative damage contributes to a range of degenerative diseases. Ubiquinones have been shown to protect mitochondria from oxidative damage, but only a small proportion of externally administered ubiquinone is taken up by mitochondria. Conjugation of the lipophilic triphenylphosphonium cation to a ubiquinone moiety has produced a compound, MitoQ, which accumulates selectively into mitochondria. MitoQ passes easily through all biological membranes and, because of its positive charge, is accumulated several hundred-fold within mitochondria driven by the mitochondrial membrane potential. MitoQ protects mitochondria against oxidative damage in vitro and following oral delivery, and may therefore form the basis for mitochondria-protective therapies.
authors: MRC Dunn Human Nutrition Unit, Wellcome Trust/MRC Building, Hills Road, Cambridge CB2 2XY, UK.
authors: Helena M
authors: HM
authors: Cochemé
authors: Geoffrey F
authors: GF
authors: Kelso
authors: Andrew M
authors: AM
authors: James
authors: Meredith F
authors: MF
authors: Ross
authors: Jan
authors: J
authors: Trnka
authors: Thabo
authors: T
authors: Mahendiran
authors: Jordi
authors: J
authors: Asin-Cayuela
authors: Frances H
authors: FH
authors: Blaikie
authors: Abdul-Rahman B
authors: AR
authors: Manas
authors: Carolyn M
authors: CM
authors: Porteous
authors: Victoria J
authors: VJ
authors: Adlam
authors: Robin A J
authors: RA
authors: Smith
authors: Michael P
authors: MP
authors: Murphy
mesh_terms: D000284:Administration, Oral; D000818:Animals; D002412:Cations; D002462:Cell Membrane / Q000378:metabolism; D006801:Humans; D053078:Membrane Potential, Mitochondrial; D008564:Membrane Potentials; D008928:Mitochondria / Q000378:metabolism*; D028361:Mitochondrial Diseases / Q000628:therapy; D008954:Models, Biological; D008956:Models, Chemical; D009943:Organophosphorus Compounds / Q000378:metabolism*; D010100:Oxygen / Q000378:metabolism; D011809:Quinones / Q000737:chemistry*; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000378:metabolism
chemical_list: D002412:Cations; D009943:Organophosphorus Compounds; D011809:Quinones; D014451:Ubiquinone; C429014:mitoquinone; D010100:Oxygen