The effects of shock waves on lung tissue in acute period: an in vivo study.
The acute effects of extracorporeal shock waves on lung morphology were studied by light microscopy in 30 New Zealand rabbits. The left kidneys of the ten animals were exposed to 2,000 shockwaves at 18 kV under anesthesia (ESWL group). Ten rabbits were in the control group; an intramuscular anesthetic agent (ketamine) and intravenous contrast media were administered to ten animals in the sham group. Localization of the left kidneys was achieved following contrast medium injection through an ear vein under fluoroscopic control. The animals were killed after the ESWL procedures and the lungs were removed. Edema, emphysema, hemorrhage, congestion, inflammation, loss of normal structure, and epithelial desquamation were determined and graded between 0 and 3 in all areas of both lungs. In order to determine whether proximity has any effect on the histopathological changes, left and right lungs were evaluated separately as well as upper and lower lobes. We found that ESWL exposed to kidney also affects all areas of the lungs in a rabbit model.
Eroglu
Muzaffer
M
Department of Urology, AIBU School of Medicine, Bolu, Turkey. docmuzer@hotmail.com
Cimentepe
Ersin
E
Demirag
Funda
F
Unsal
Ebru
E
Unsal
Ali
A
D000818:Animals; D006470:Hemorrhage / Q000209:etiology; D007668:Kidney / Q000473:pathology; D008096:Lithotripsy / Q000009:adverse effects*; D008168:Lung / Q000473:pathology*; D008171:Lung Diseases / Q000209:etiology; D008297:Male; D023421:Models, Animal; D011650:Pulmonary Alveoli / Q000473:pathology; D011817:Rabbits; D020545:Respiratory Mucosa / Q000473:pathology; D013997:Time Factors