Effects of Tribuli saponins on ventricular remodeling after myocardial infarction in hyperlipidemic rats.
This experiment was designed to determine whether Tribuli saponins (TS) relieve left ventricular remodeling (VR) after myocardial infarction (MI) in a murine hyperlipemia (HL) model. MI and HL models were induced and high and low doses of TS and simvastatin were administrated to the rats. Four weeks later, echocardiographic observation was performed and the left and right ventricular weight index (LVWI, RVWI) was calculated. Echocardiographic results showed that both high dose of TS and simvastatin had a beneficial effect on increasing fractional shortening (FS) and ejection fraction (EF), reducing left ventricular end diastolic volume (LVEDV), systolic volume (LVESV), left ventricular dimension end diastole (LVDd) and systole (LVDs), and decreasing LVWI, as compared to those in the HL-MI model group (p < 0.05, 0.01). Both medicines had little impact on thickness of the anterior and posterior wall. No significant difference was observed between each treatment group (p > 0.05). In conclusion, TS not only lowered serum lipidemia, but also relieved left ventricular remodeling, and improved cardiac function in the early stage after MI.
Guo
Yan
Y
Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China.
Shi
Da-Zhuo
DZ
Yin
Hui-Jun
HJ
Chen
Ke-Ji
KJ
D000818:Animals; D002306:Cardiac Volume / Q000187:drug effects; D002784:Cholesterol / Q000097:blood; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D006352:Heart Ventricles / Q000000981:diagnostic imaging; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology; D006949:Hyperlipidemias / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D009203:Myocardial Infarction / Q000503:physiopathology*; D010936:Plant Extracts / Q000494:pharmacology; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012503:Saponins / Q000494:pharmacology*; D019821:Simvastatin / Q000494:pharmacology; D013318:Stroke Volume / Q000187:drug effects; D032444:Tribulus; D014463:Ultrasonography; D020257:Ventricular Remodeling / Q000187:drug effects* / Q000502:physiology
D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D010936:Plant Extracts; D012503:Saponins; D002784:Cholesterol; D019821:Simvastatin