Natriuretic peptide receptor B signaling in the cardiovascular system: protection from cardiac hypertrophy.
Natriuretic peptides (NP) represent a family of structurally homologous but genetically distinct peptide hormones involved in regulation of fluid and electrolyte balance, blood pressure, fat metabolism, cell proliferation, and long bone growth. Recent work suggests a role for natriuretic peptide receptor B (NPR-B) signaling in regulation of cardiac growth by either a direct effect on cardiomyocytes or by modulation of other signaling pathways including the autonomic nervous system. The research links NPR-B for the first time to a cardiac phenotype in vivo and underlines the importance of the NP in the cardiovascular system. This manuscript will focus on the role of NPR-B and its ligand C-type natriuretic peptide in cardiovascular physiology and disease and will evaluate these new findings in the context of the known function of this receptor, with a perspective on how future research might further elucidate NPR-B function.
Pagel-Langenickel
Ines
I
National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA. langenit@mail.nih.gov
Buttgereit
Jens
J
Bader
Michael
M
Langenickel
Thomas H
TH
D000818:Animals; D006332:Cardiomegaly / Q000378:metabolism / Q000503:physiopathology*; D002320:Cardiovascular Physiological Phenomena; D002319:Cardiovascular System / Q000378:metabolism; D006162:Guanylate Cyclase / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D020098:Natriuretic Peptide, C-Type / Q000378:metabolism / Q000502:physiology; D017461:Receptors, Atrial Natriuretic Factor / Q000378:metabolism / Q000502:physiology*; D015398:Signal Transduction; D000099242:Atrial Natriuretic Factor Receptor B
D006162:Guanylate Cyclase; D020098:Natriuretic Peptide, C-Type; D017461:Receptors, Atrial Natriuretic Factor; D000099242:Atrial Natriuretic Factor Receptor B