title: Epidemiology, genes and the environment: lessons learned from the Helsinki Birth Cohort Study.
abstract: Nonoptimal growth during fetal life and infancy is associated with an increased risk of coronary heart disease and type 2 diabetes later in life. This early pattern of growth is associated with an increased disease risk especially when followed by a relative gain in body size later in childhood. Genetic factors are closely involved in growth and disease pathogenesis and gene-early life environmental interactions will be described affecting adult health outcomes. This overview will primarily focus upon findings from the Helsinki Birth Cohort Study consisting of 15846 subjects born 1924-1944 on whom growth data and information on adult health are available.
authors: Department of Public Health, University of Helsinki, Helsinki, Finland. johan.eriksson@helsinki.fi
authors: J G
authors: JG
authors: Eriksson
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002657:Child Development / Q000502:physiology; D015331:Cohort Studies; D003327:Coronary Disease / Q000209:etiology* / Q000235:genetics / Q000503:physiopathology; D003924:Diabetes Mellitus, Type 2 / Q000209:etiology* / Q000235:genetics / Q000503:physiopathology; D005260:Female; D005317:Fetal Growth Retardation / Q000503:physiopathology; D005387:Finland; D006801:Humans; D007223:Infant; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007328:Insulin / Q000378:metabolism; D008297:Male; D009765:Obesity / Q000150:complications / Q000503:physiopathology; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000503:physiopathology
chemical_list: D007328:Insulin