title: Targeted brain hypothermia induced by an interstitial cooling device in human neck: theoretical analyses.
abstract: In this study, the feasibility of a newly developed interstitial cooling device inserted into the neck muscle and placed on the surface of the common carotid artery is evaluated. A combination of vascular model and continuum model is developed to simulate the temperature fields in both the neck and brain regions. Parametric studies are conducted to test the sensitivity of various factors on the temperature distribution. It has been shown that the length of the device, temperature of the device, and the tissue gap between the device and the blood vessel are the dominant factors that determine the effectiveness of this cooling approach. Under the current design parameters, the device is capable of inducing a temperature drop of 2.8 degrees C along the common carotid artery and it results in a total of 90 W of heat carried away from the arterial blood. Although the degree of the cooling in the arterial blood is inversely proportional to the blood flow rate of the arteries, the total heat loss from the arterial blood does not vary significantly if the blood flow rate changes during the cooling. After the cold arterial blood is supplied to the brain hemisphere, temperature reduction in the brain tissue is almost uniform and up to 3.1 degrees C temperature drop is achieved within 1 hour. In addition to the possible benefits of brain hypothermia for stroke or head injury patients, the device has the potential to control fever as well as to improve patients' outcome during open neck and head surgery.
authors: Department of Mechanical Engineering, University of Maryland Baltimore County, Baltimore, MD 21250, USA.
authors: Yunjian
authors: Y
authors: Wang
authors: Liang
authors: L
authors: Zhu
mesh_terms: D001783:Blood Flow Velocity; D001831:Body Temperature; D001921:Brain / Q000098:blood supply / Q000502:physiology; D003198:Computer Simulation; D017679:Cryotherapy / Q000295:instrumentation / Q000379:methods; D004735:Energy Transfer; D004867:Equipment Design; D006358:Hot Temperature; D006801:Humans; D007036:Hypothermia, Induced / Q000295:instrumentation* / Q000379:methods*; D008955:Models, Cardiovascular; D009333:Neck / Q000098:blood supply / Q000502:physiology; D019736:Prostheses and Implants; D011482:Protective Devices; D013997:Time Factors