Effects of organohalogen pollutants on haematological and urine clinical-chemical parameters in Greenland sledge dogs (Canis familiaris).
Seven West Greenland sledge dog bitches (Canis familiaris) and their three pups were fed 50-200 g of contaminated West Greenland minke whale (Balaenoptera acutorostrata) blubber, and in a control cohort eight sister bitches and their five pups were fed a similar amount pork fat. Blood plasma and urine clinical-chemical parameters were measured and compared between the bitches and pups form the control and exposed cohorts. Based on existing reference intervals, Arctic mammals may have blood clinical-chemical endpoint levels that differ from comparable species at lower latitudes. The cortisol:creatinine ratio, protein:creatinine ratio, alkaline phosphatase, cholesterol and inorganic phosphate were significantly highest (ANCOVA: all p<0.05) in the pup generation. The cortisol:creatinine ratio, cholesterol, lactate dehydrogenase and creatinine kinase were significantly higher (ANCOVA: all p<0.05) in the control group, while glucose was significantly highest (ANCOVA: p<0.05) in the exposed group. Furthermore, the blood cholesterol levels indicate that exposure via the diet to marine mammal blubber has a preventive effect on the development of cardiovascular diseases. We therefore suggest that the consumption of contaminated Arctic marine blubber impacted liver and kidney function in adult and pup sledge dogs.
Sonne
Christian
C
Section for Contaminants and Marine Mammals, Department of Arctic Environment, National Environmental Research Institute, University of Aarhus, Roskilde, Denmark. csh@dmu.dk
Dietz
Rune
R
Kirkegaard
Maja
M
Letcher
Robert J
RJ
Shahmiri
Soheila
S
Andersen
Steen
S
Møller
Per
P
Olsen
Aage Kristian
AK
Jensen
Asger L
AL
D000273:Adipose Tissue; D000375:Aging; D000821:Animal Feed; D000818:Animals; D001110:Arctic Regions; D001774:Blood Chemical Analysis; D001835:Body Weight; D003404:Creatinine / Q000097:blood; D004285:Dogs; D004785:Environmental Pollutants / Q000633:toxicity*; D005260:Female; D006116:Greenland; D006219:Halogens / Q000633:toxicity*; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D013552:Swine; D014907:Whales
D004785:Environmental Pollutants; D006219:Halogens; D003404:Creatinine; D006854:Hydrocortisone