Plasma coagulation factor levels in venous thrombosis.
High plasma levels of several coagulation factors have been described to be associated with an increased risk of venous thrombosis. However, the mechanisms underlying these associations, as well as those involved in the regulation of plasma levels of coagulation factors, are mostly unknown. Whether these factors should be included in the workup of patients with venous thrombosis remains to be determined. In this review, we discuss the present knowledge on the effects of plasma levels of coagulation factors on the development of venous thrombosis. Furthermore, we review recent findings and ideas on the mechanisms through which elevated plasma coagulation factor levels may influence thrombosis. Finally, we enter into the matter of the possible determinants of elevated plasma levels of coagulation factors.
Nossent
A Yaël
AY
Hemostasis and Thrombosis Research Center, Department of Hematology, Leiden University Medical Center, Leiden, the Netherlands.
Eikenboom
Jeroen C J
JC
Bertina
Rogier M
RM
D001777:Blood Coagulation / Q000502:physiology*; D001779:Blood Coagulation Factors / Q000032:analysis* / Q000235:genetics; D006801:Humans; D012307:Risk Factors; D020246:Venous Thrombosis / Q000097:blood / Q000503:physiopathology*
D001779:Blood Coagulation Factors