title: CD36 and macrophages in atherosclerosis.
abstract: CD36 is a multi-ligand scavenger receptor present on the surface of a number of cells such as platelets, monocytes/macrophages, endothelial and smooth muscle cells. Monocyte/macrophage CD36 has been shown to play a critical role in the development of atherosclerotic lesions by its capacity to bind and endocytose oxidized low density lipoproteins (OxLDL), and it is implicated in the formation of foam cells. However, the significance of CD36 in atherosclerosis has recently been called into question by different studies, and therefore its exact role still needs to be clarified. The aim of this article is to carefully review the importance of CD36 as an essential component in the pathogenesis of atherosclerosis.
authors: Cardiovascular Division, King's College, London, UK. sophie.collot@kcl.ac.uk
authors: Sophie
authors: S
authors: Collot-Teixeira
authors: Juliette
authors: J
authors: Martin
authors: Chris
authors: C
authors: McDermott-Roe
authors: Robin
authors: R
authors: Poston
authors: John Louis
authors: JL
authors: McGregor
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000276:immunology* / Q000473:pathology; D001808:Blood Vessels / Q000276:immunology / Q000473:pathology; D018955:CD36 Antigens / Q000378:metabolism*; D006801:Humans; D008077:Lipoproteins, LDL / Q000378:metabolism; D008264:Macrophages / Q000378:metabolism*; D051379:Mice; D008822:Mice, Transgenic; D023421:Models, Animal; D013329:Structure-Activity Relationship
chemical_list: D018955:CD36 Antigens; D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein