Growth in pediatric renal transplant recipients.
One of the fundamental challenges in managing pediatric renal transplant recipient is to ensure normal growth and development. The goal of renal transplant is not just to prolong life but to optimize quality of life. Short stature during childhood may be associated with academic underachievement and development of comorbidities such as attention deficit hyperactivity disorder, learning disability, and mood disorders. The most important factors affecting growth are use of corticosteroids, allograft function, and age and height deficit at the time of transplant. Aggressive conservative management of chronic renal failure and early use of growth hormone therapy will help in optimizing height at time of transplant. Early transplant, steroid minimization or withdrawal, and growth hormone therapy will help in achieving normal adult height in a majority of renal post transplant population. Steroid avoidance to achieve good growth still needs to be validated.
Vasudevan
A
A
Children Kidney Care Center, St John's Medical College, Bangalore, India.
Phadke
K
K
D000305:Adrenal Cortex Hormones / Q000009:adverse effects; D000328:Adult; D001827:Body Height; D002648:Child; D002675:Child, Preschool; D006128:Growth / Q000502:physiology*; D006130:Growth Disorders / Q000209:etiology*; D006801:Humans; D007223:Infant; D016030:Kidney Transplantation / Q000009:adverse effects / Q000502:physiology*; D008137:Longitudinal Studies; D013997:Time Factors
D000305:Adrenal Cortex Hormones