Fishing for allergens hiding as prohaptens.
Enzymes of the cytochrome P450 (CYP) superfamily are the most versatile and important class of drug-metabolizing enzymes, involved in the metabolism of xenobiotics to which human skin is exposed. Bergström et al. used a recombinant human CYP cocktail in ratios that simulate those found in human skin for the purpose of identifying prohapten metabolites of otherwise inert molecules.
Mukhtar
Hasan
H
Department of Dermatology, University of Wisconsin, Madison, Wisconsin 53706, USA. hmukhtar@wisc.edu
Afaq
Farrukh
F
Matsui
Mary S
MS
D000485:Allergens / Q000276:immunology / Q000378:metabolism*; D001711:Biotransformation / Q000502:physiology; D003577:Cytochrome P-450 Enzyme System / Q000502:physiology*; D006241:Haptens / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D012867:Skin / Q000201:enzymology* / Q000276:immunology; D015262:Xenobiotics / Q000378:metabolism
D000485:Allergens; D006241:Haptens; D015262:Xenobiotics; D003577:Cytochrome P-450 Enzyme System