[Complex analysis of prognostic factors in chronic lymphocytic leukemia].
BACKGROUND
Many new prognostic factors established in recent years in chronic lymphocytic leukemia. May help predicting survival.


OBJECTIVE
The goal of the present study was to determine the frequency and the correlation of these novel prognostic factors in samples of 419 leukemia patients.


METHODS
The mutation status of the IgH gene was evaluated in 160 cases.


RESULTS
In 62% of cases, non-mutated IgH gene was found, the heavy chain family usage was different in mutated and non-mutated cases. The CD38 expression demonstrated 78% concordance with the mutation status, the ZAP-70 expression failed to show any correlation. Cytogenetic abnormalities were seen in 76% of cases, the most frequent were del(13q) (57%), trisomy 12 (15%), del(11q) (12%) and del(17p) (6%). 95% of cases with del(11q) harbored non-mutated, 74% of cases with del(13q) as the sole anomaly demonstrated mutated IgH genes.


CONCLUSIONS
The parameters analysed are not independent of each other, utilization of them in the clinical routine needs careful planning.
Kajtár
Béla
B
Pécsi Tudományegyetem, Altalános Orvostudományi Kar, Patológiai Intézet, Pécs. bkajtar@pathology.pote.hu
Jáksó
Pál
P
Kereskai
László
L
Lacza
Agnes
A
Méhes
Gábor
G
Bodnár
Mária Anna
MA
Dombi
J Péter
JP
Gasztonyi
Zoltán
Z
Egyed
Miklós
M
Iványi
János László
JL
Kovács
Gábor
G
Marton
Eva
E
Palaczki
Aranka
A
Petz
Sándor
S
Tóth
Péter
P
Sziládi
Erzsébet
E
Losonczy
Hajna
H
Pajor
László
L
D051997:ADP-ribosyl Cyclase 1 / Q000378:metabolism; D000368:Aged; D002880:Chromosomes, Human, Pair 11; D002882:Chromosomes, Human, Pair 13; D002886:Chromosomes, Human, Pair 17; D004273:DNA, Neoplasm / Q000032:analysis; D005260:Female; D005434:Flow Cytometry; D017353:Gene Deletion; D015321:Gene Rearrangement; D050438:Genes, Immunoglobulin Heavy Chain / Q000235:genetics*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000175:diagnosis* / Q000235:genetics* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009154:Mutation; D011237:Predictive Value of Tests; D011379:Prognosis; D017422:Sequence Analysis, DNA; D016019:Survival Analysis; D014314:Trisomy; D051746:ZAP-70 Protein-Tyrosine Kinase / Q000378:metabolism
D004273:DNA, Neoplasm; D051746:ZAP-70 Protein-Tyrosine Kinase; D051997:ADP-ribosyl Cyclase 1