Effects of motor cortex rTMS on lower urinary tract dysfunction in multiple sclerosis.
We tested the effects of 5-Hz rTMS over the motor cortex in multiple sclerosis (MS) subjects complaining of lower urinary tract symptoms either in the filling or voiding phase. Our data show that motor cortex stimulation for five consecutive days over two weeks ameliorates the voiding phase of the micturition cycle, suggesting that enhancing corticospinal tract excitability might be useful to ameliorate detrusor contraction and/or urethral sphincter relaxation in MS patients with bladder dysfunction.
Centonze
D
D
Dipartimento di Neuroscienze, Clinica Neurologica, Università Tor Vergata, Rome, Italy and Fondazione Santa Lucia IRCCS, Rome, Italy. centonze@uniroma2.it
Petta
F
F
Versace
V
V
Rossi
S
S
Torelli
F
F
Prosperetti
C
C
Rossi
St
S
Marfia
G A
GA
Bernardi
G
G
Koch
G
G
Miano
R
R
Boffa
L
L
Finazzi-Agrò
E
E
D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009044:Motor Cortex / Q000502:physiology; D009103:Multiple Sclerosis / Q000150:complications*; D011712:Pyramidal Tracts / Q000502:physiology; D050781:Transcranial Magnetic Stimulation; D016896:Treatment Outcome; D053201:Urinary Bladder, Overactive / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D014555:Urination Disorders / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*