Experimental IUGR and later diabetes.
It is widely accepted that an association exists between the intrauterine environment in which a fetus grows and develops and the subsequent development of type 2 diabetes. Any disturbance in maternal ability to provide nutrients and oxygen to the fetus can lead to fetal intrauterine growth restriction (IUGR). Here we will review IUGR in rodent models, in which maternal metabolism has been experimentally manipulated to investigate the molecular basis of the relationship between IUGR and development of type 2 diabetes in later life, and the identification of the molecular derangements in specific metabolically - sensitive organs/tissues.
Martin-Gronert
M S
MS
Department of Clinical Biochemistry, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK.
Ozanne
S E
SE
D000818:Animals; D031204:Caloric Restriction; D003924:Diabetes Mellitus, Type 2 / Q000209:etiology* / Q000235:genetics / Q000378:metabolism; D016640:Diabetes, Gestational / Q000378:metabolism; D004044:Dietary Proteins / Q000008:administration & dosage; D004195:Disease Models, Animal; D044127:Epigenesis, Genetic / Q000235:genetics; D005260:Female; D005317:Fetal Growth Retardation / Q000235:genetics / Q000378:metabolism*; D048070:Fetal Nutrition Disorders / Q000378:metabolism; D005938:Glucocorticoids / Q000009:adverse effects; D006801:Humans; D007328:Insulin / Q000378:metabolism; D028361:Mitochondrial Diseases / Q000378:metabolism; D010920:Placenta / Q000378:metabolism; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology; D014599:Uterus / Q000378:metabolism
D004044:Dietary Proteins; D005938:Glucocorticoids; D007328:Insulin