title: Variable platelet response to aspirin and clopidogrel in atherothrombotic disease.
authors: Division of Cardiology, Harvard Medical School and Massachusetts General Hospital, Boston, Mass, USA.
authors: Andrew O
authors: AO
authors: Maree
authors: Desmond J
authors: DJ
authors: Fitzgerald
mesh_terms: D000244:Adenosine Diphosphate / Q000502:physiology; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D001241:Aspirin / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D050197:Atherosclerosis / Q000097:blood / Q000188:drug therapy*; D015415:Biomarkers; D001711:Biotransformation / Q000235:genetics; D001780:Blood Coagulation Tests; D001792:Blood Platelets / Q000187:drug effects* / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000517:prevention & control; D000077144:Clopidogrel; D051545:Cyclooxygenase 1 / Q000502:physiology; D016861:Cyclooxygenase Inhibitors / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D004347:Drug Interactions; D004351:Drug Resistance / Q000235:genetics; D006470:Hemorrhage / Q000139:chemically induced; D006801:Humans; D015539:Platelet Activation / Q000187:drug effects* / Q000502:physiology; D010975:Platelet Aggregation Inhibitors / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D010979:Platelet Function Tests; D011446:Prospective Studies; D016032:Randomized Controlled Trials as Topic; D018048:Receptors, Purinergic P2 / Q000187:drug effects / Q000502:physiology; D058472:Receptors, Purinergic P2Y1; D058925:Receptors, Purinergic P2Y12; D013927:Thrombosis / Q000097:blood / Q000188:drug therapy*; D013928:Thromboxane A2 / Q000502:physiology; D013929:Thromboxane B2 / Q000031:analogs & derivatives / Q000652:urine; D013988:Ticlopidine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D017211:Treatment Failure
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D015415:Biomarkers; D016861:Cyclooxygenase Inhibitors; C546382:P2RY1 protein, human; C548576:P2RY12 protein, human; D010975:Platelet Aggregation Inhibitors; D018048:Receptors, Purinergic P2; D058472:Receptors, Purinergic P2Y1; D058925:Receptors, Purinergic P2Y12; D013929:Thromboxane B2; D013928:Thromboxane A2; D000244:Adenosine Diphosphate; C049235:11-dehydro-thromboxane B2; D000077144:Clopidogrel; D051545:Cyclooxygenase 1; D013988:Ticlopidine; D001241:Aspirin