title: Phyllodes tumors of the breast: natural history, diagnosis, and treatment.
abstract: Phyllodes tumors of the breast are unusual fibroepithelial tumors that exhibit a wide range of clinical behavior. These tumors are categorized as benign, borderline, or malignant based on a combination of histologic features. The prognosis of phyllodes tumors is favorable, with local recurrence occurring in approximately 15% of patients overall and distant recurrence in approximately 5% to 10% overall. Wide excision with a greater than 1 cm margin is definitive primary therapy. Adjuvant systemic therapy is of no proven value. Patients with locally recurrent disease should undergo wide excision of the recurrence with or without subsequent radiotherapy.
authors: Department of Medicine, Stanford University, Stanford, CA, USA.
authors: Melinda L
authors: ML
authors: Telli
authors: Kathleen C
authors: KC
authors: Horst
authors: Alice E
authors: AE
authors: Guardino
authors: Frederick M
authors: FM
authors: Dirbas
authors: Robert W
authors: RW
authors: Carlson
mesh_terms: D001943:Breast Neoplasms / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D005260:Female; D006801:Humans; D003557:Phyllodes Tumor / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D011379:Prognosis