title: Solid type clear cell carcinoma of the pancreas: differential diagnosis of an unusual case and review of the literature.
abstract: Pancreatic neoplasms have been reliably classified on the basis of their histopathology and immunophenotype. In this study, we report on a pancreatic tumor whose phenotype and genotype could not be assigned to any known tumor entity. The tumor was observed in the pancreatic head of a 54-year-old woman. It was found to be a solid infiltrating carcinoma with abundant clear cells. Apart from cytokeratin, the tumor cells expressed vimentin, S100, and MUC-1. DNA microarray analysis revealed a transcription profile clearly differing from that of normal pancreatic tissue and pancreatic ductal adenocarcinoma. Despite metastatic behavior, the tumor displayed a more favorable course than conventional pancreatic ductal adenocarcinoma. We suggest that this tumor be called solid type clear cell carcinoma of the pancreas.
authors: Department of General Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany.
authors: Martin
authors: M
authors: Loos
authors: Frank
authors: F
authors: Bergmann
authors: Andrea
authors: A
authors: Bauer
authors: Jörg D
authors: JD
authors: Hoheisel
authors: Irene
authors: I
authors: Esposito
authors: Jörg
authors: J
authors: Kleeff
authors: Peter
authors: P
authors: Schirmacher
authors: Markus W
authors: MW
authors: Büchler
authors: Günter
authors: G
authors: Klöppel
authors: Helmut
authors: H
authors: Friess
mesh_terms: D018262:Adenocarcinoma, Clear Cell / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology / Q000556:secondary; D003937:Diagnosis, Differential; D005260:Female; D020869:Gene Expression Profiling; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000378:metabolism; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary; D046228:Microarray Analysis; D008875:Middle Aged; D018396:Mucin-1 / Q000378:metabolism; D020411:Oligonucleotide Array Sequence Analysis; D010190:Pancreatic Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D020133:Reverse Transcriptase Polymerase Chain Reaction; D009418:S100 Proteins / Q000378:metabolism; D036542:Tomography, Spiral Computed; D014746:Vimentin / Q000378:metabolism
chemical_list: C060192:MUC1 protein, human; D018396:Mucin-1; D009418:S100 Proteins; D014746:Vimentin; D007633:Keratins