title: Unexpected chiroptical inversion observed for supramolecular complexes formed between an achiral polythiophene and ATP.
abstract: A series of supramolecular complexes between a water-soluble achiral polythiophene derivative (PT-1) and various nucleotides has been prepared. It was found that upon the introduction of adenosine diphosphate (ADP), adenosine triphosphate (ATP), and uridine triphosphate (UTP) into aqueous solutions of achiral PT-1, which has a random-coiled conformation, chiral supramolecular pi-stacked aggregates of PT-1 can be constructed. These complexes exhibit an unique split-type induced circular dichroism (ICD) in the pi-pi* transition region of the main chain. In particular, it was found that the Cotton effect of the chiral supramolecular PT-1/ATP aggregates reveals a dramatic inversion of chirality with a change in the concentration of ATP, which has not been previously observed in chiral macromolecular complexes. On the basis of extensive investigations performed with UV/Vis spectroscopy, CD spectroscopy, TEM, AFM, and dynamic light scattering (DLS), a possible mechanism for the formation of chiral superstructures of PT-1 and chiroptical inversion induced by changes in ATP concentration is proposed.
authors: Department of Chemistry and Biochemistry, Graduated School of Engineering, Kyushu University, Fukuoka 819-0395, Japan.
authors: Chun
authors: C
authors: Li
authors: Munenori
authors: M
authors: Numata
authors: Masayuki
authors: M
authors: Takeuchi
authors: Seiji
authors: S
authors: Shinkai
mesh_terms: D000255:Adenosine Triphosphate / Q000737:chemistry*; D002942:Circular Dichroism; D046529:Microscopy, Electron, Transmission; D055095:Optics and Photonics; D011108:Polymers / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D013237:Stereoisomerism; D013876:Thiophenes / Q000737:chemistry*
chemical_list: D011108:Polymers; D013876:Thiophenes; C066730:polythiophene; D000255:Adenosine Triphosphate