Genotoxicity screening for N-nitroso compounds. Electrochemical and electrochemiluminescent detection of human enzyme-generated DNA damage from N-nitrosopyrrolidine.
We report for the first time voltammetric/electrochemiluminescent sensors applied to predict genotoxicity of N-nitroso compounds bioactivated by human cytochrome P450 enzymes.
Krishnan
Sadagopan
S
Department of Chemistry (U-60), 55 N. Eagleville Rd., University of Connecticut, Connecticut, USA.
Hvastkovs
Eli G
EG
Bajrami
Besnik
B
Jansson
Ingela
I
Schenkman
John B
JB
Rusling
James F
JF
D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D004247:DNA / Q000737:chemistry / Q000378:metabolism*; D004249:DNA Damage / Q000187:drug effects*; D004563:Electrochemistry; D006801:Humans; D008163:Luminescent Measurements; D015394:Molecular Structure; D009242:N-Nitrosopyrrolidine / Q000737:chemistry / Q000378:metabolism* / Q000633:toxicity*
D004247:DNA; D003577:Cytochrome P-450 Enzyme System; D009242:N-Nitrosopyrrolidine