[Experimental studies on treatment of HSV infections with photodynamic therapy using 5-aminolevulinic acid].
OBJECTIVE
To investigate in vitro and in vivo anti-human herpes simplex virus effects of photodynamic therapy (PDT) using 5-aminolevulinic acid (ALA).


METHODS
Guinea pigs model of cutaneous herpes virus infection was applied, and Vero cells infected by HSV-I and HSV-II were used as experimental systems to observe the antiherpes effect of ALA-PDT.


RESULTS
The in vitro experiments showed that ALA-PDT has antiherpes effect on HSV-I and HSV-II, its effect was similar to that of acyclovir. The results of animal experiments showed that ALA-PDT had significant therapeutic effect on guinea pigs model of cutaneous herpes virus infection, the effect was dose-related.


CONCLUSIONS
ALA-PDT could be effective in treating HSV infections, which may provide a new approach to the treatment of viral infections.
Tao
Ji-ning
JN
Shanghai Fudan-Zhangjiang Bio-pharmaceutical Co., Ltd, Shanghai 201203, China.
Duan
Shu-min
SM
Li
Jun
J
D000622:Aminolevulinic Acid / Q000627:therapeutic use*; D000818:Animals; D002522:Chlorocebus aethiops; D004195:Disease Models, Animal; D005260:Female; D006168:Guinea Pigs; D006561:Herpes Simplex / Q000188:drug therapy* / Q000821:virology; D008297:Male; D010778:Photochemotherapy; D011897:Random Allocation; D018139:Simplexvirus / Q000187:drug effects*; D017193:Skin Diseases, Viral / Q000188:drug therapy; D016896:Treatment Outcome; D014709:Vero Cells
D000622:Aminolevulinic Acid