Catalytic asymmetric formation of beta-sultams.
beta-Sultams, highly strained sulfonyl analogues of beta-lactams, were prepared enantio- and diastereoselectively by tertiary amine catalyzed [2 + 2] cycloaddition reactions. The title compounds are practical precursors of highly enantioenriched biologically interesting beta-aminosulfonyl derivatives.
Zajac
Marian
M
Laboratory of Organic Chemistry, ETH Zürich, Wolfgang-Pauli-Strasse 10, Hönggerberg HCI E 111, Zürich, Switzerland.
Peters
René
R
D002384:Catalysis; D018360:Crystallography, X-Ray; D008958:Models, Molecular; D015394:Molecular Structure; D013237:Stereoisomerism; D013441:Sulfinic Acids / Q000737:chemistry; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000737:chemistry
D013441:Sulfinic Acids; D013449:Sulfonamides; C480101:beta-sultam; C044255:sulfonyl chloride