title: Fast and sensitive trace analysis of malachite green using a surface-enhanced Raman microfluidic sensor.
abstract: A rapid and highly sensitive trace analysis technique for determining malachite green (MG) in a polydimethylsiloxane (PDMS) microfluidic sensor was investigated using surface-enhanced Raman spectroscopy (SERS). A zigzag-shaped PDMS microfluidic channel was fabricated for efficient mixing between MG analytes and aggregated silver colloids. Under the optimal condition of flow velocity, MG molecules were effectively adsorbed onto silver nanoparticles while flowing along the upper and lower zigzag-shaped PDMS channel. A quantitative analysis of MG was performed based on the measured peak height at 1615 cm(-1) in its SERS spectrum. The limit of detection, using the SERS microfluidic sensor, was found to be below the 1-2 ppb level and this low detection limit is comparable to the result of the LC-Mass detection method. In the present study, we introduce a new conceptual detection technology, using a SERS microfluidic sensor, for the highly sensitive trace analysis of MG in water.
authors: Department of Applied Chemistry, Hanyang University, Ansan 426-791, South Korea.
authors: Sangyeop
authors: S
authors: Lee
authors: Junghyun
authors: J
authors: Choi
authors: Lingxin
authors: L
authors: Chen
authors: Byungchoon
authors: B
authors: Park
authors: Jin Burm
authors: JB
authors: Kyong
authors: Gi Hun
authors: GH
authors: Seong
authors: Jaebum
authors: J
authors: Choo
authors: Yeonjung
authors: Y
authors: Lee
authors: Kyung-Hoon
authors: KH
authors: Shin
authors: Eun Kyu
authors: EK
authors: Lee
authors: Sang-Woo
authors: SW
authors: Joo
authors: Kyeong-Hee
authors: KH
authors: Lee
mesh_terms: D046210:Microfluidic Analytical Techniques / Q000379:methods*; D012394:Rosaniline Dyes / Q000032:analysis*; D013059:Spectrum Analysis, Raman / Q000379:methods*
chemical_list: D012394:Rosaniline Dyes; C005095:malachite green