Multiple indomethacin-induced jejunal ulcerations with perforation: a case report with histology.
Gastric and duodenal inflammation and ulceration are well-known complications of nonsteroidal anti-inflammatory (NSAID) usage. However, small bowel ulceration and perforation secondary to NSAID use is uncommon and has rarely been reported in the literature. We describe a perforated jejunal ulcer that developed in a patient using indomethacin for treatment of ankylosing spondylitis. We performed a literature review of NSAID-induced small bowel injury and compared the histology of NSAID-related injury with more familiar causes of small bowel perforation.
Risty
Gina M
GM
From the Department of General and Vascular Surgery, Gundersen Lutheran, La Crosse, Wisconsin 54601, USA.
Najarian
Melissa M
MM
Shapiro
Stephen B
SB
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007213:Indomethacin / Q000009:adverse effects*; D007413:Intestinal Mucosa / Q000473:pathology; D007579:Jejunal Diseases / Q000139:chemically induced* / Q000473:pathology; D008875:Middle Aged; D010439:Peptic Ulcer Perforation / Q000139:chemically induced* / Q000473:pathology; D013167:Spondylitis, Ankylosing / Q000188:drug therapy
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007213:Indomethacin