title: [Clinical control study of dialysates with different concentrations of calcium on blood pressure in patients under hemodialysis for prolonged period].
abstract: OBJECTIVE
  To investigate the changes in blood pressure in hemodialysis patients treated with low calcium dialysate or high calcium dialysate for long time.
  
  
  METHODS
  Fifteen patients undergoing hemodialysis were enrolled in this study. High calcium dialysate (1.75 mmol/L, Dca1.75) was first used for 6 months, then low calcium dialysate (1.25 mmol/L, Dca1.25) was used for 6 months. Serum calcium, phosphate, blood urea nitrogen, and creatinine were measured, blood pressure was recorded before and after hemodialysis at the beginning, and also at 1, 2, 3 and 4 hours after hemodialysis.
  
  
  RESULTS
  Compared with that before the treatment, systolic and diastolic blood pressure lowered significantly after single low calcium hemodialysis for 4 hours (both P<0.05), while systolic and diastolic blood pressure rose significantly after single high calcium hemodialysis (both P<0.05). Systolic blood pressure changed more obviously after two hemodialyses (both P<0.05). Changes in systolic, diastolic and mean blood pressure were positively related to changes in serum total calcium (r(1)=0.326, P(1)=0.054; r(2)=0.383, P(2)=0.037; r(3)=0.391, P(3)=0.032). During 6 months of hemodialysis with low calcium dialysate, blood pressure lowered slightly with no significant difference in it (P>0.05), while systolic blood pressure rose during 6 months of hemodialysis with high calcium dialysate (P<0.05). Changes in systolic blood pressure were significantly different between two groups using dialysates with different calcium concentrations (P<0.05).
  
  
  CONCLUSIONS
  Systolic blood pressure and incidence of hypertension decrease after single low calcium hemodialysis.
authors: Department of Nephrology, The Third Hospital Affiliated to Sun Yat-sen University, Guangzhou, Guangdong, China. wcgz@medmail.com.cn
authors: Cheng
authors: C
authors: Wang
authors: Tan-Qi
authors: TQ
authors: Lou
authors: Zhu-Jiang
authors: ZJ
authors: Chen
authors: Hua
authors: H
authors: Tang
authors: Cheng-Gang
authors: CG
authors: Shi
authors: Xue-Qing
authors: XQ
authors: Yu
authors: Pei-da
authors: PD
authors: Yin
mesh_terms: D001794:Blood Pressure / Q000187:drug effects* / Q000502:physiology; D002118:Calcium / Q000008:administration & dosage / Q000494:pharmacology*; D015314:Dialysis Solutions / Q000737:chemistry*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000209:etiology / Q000517:prevention & control; D008297:Male; D006435:Renal Dialysis / Q000009:adverse effects
chemical_list: D015314:Dialysis Solutions; D002118:Calcium