Ultrasound promoted ZrCl(4) catalyzed rapid synthesis of substituted 1,2,3,4-tetrahydropyrimidine-2-ones in solvent or dry media.
Sonication of aromatic aldehydes, urea and ethyl acetoacetate in presence of solvent (ethyl alcohol) or solvent-less dry media (bentonite clay) supported-zirconium (IV) chloride (ZrCl(4)) as catalyst at 35 kHz gives 6-methyl-4-substitutedphenyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl esters proficiently in high yields.
Kumar
Harish
H
Department of Chemistry, Sant Longowal Institute of Engineering and Technology, Longowal 148 106, Punjab, India. hk67@rediffmail.com
Parmar
Anupama
A
D000447:Aldehydes / Q000737:chemistry; D001546:Bentonite / Q000737:chemistry; D002384:Catalysis; D002712:Chlorides / Q000737:chemistry* / Q000528:radiation effects; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D011744:Pyrimidinones / Q000138:chemical synthesis*; D012997:Solvents; D014465:Ultrasonics; D014508:Urea / Q000737:chemistry; D015040:Zirconium / Q000737:chemistry* / Q000528:radiation effects
D000447:Aldehydes; D002712:Chlorides; D011744:Pyrimidinones; D012997:Solvents; D001546:Bentonite; D014508:Urea; D015040:Zirconium; C429984:zirconium chloride