title: Discovery of novel indazole-linked triazoles as antifungal agents.
abstract: The in vitro and in vivo activities of a series of (2R,3R)-2-(2,4-difluorophenyl)-3-(substituted indazol-1-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol as potential antifungal agents are described. In particular, the analog 12j having 5-bromo substitution on the indazole ring exhibited significant antifungal activity against a variety of fungal cultures (Candida spp. and Aspergillus spp.). In addition, oral administration of 12j showed its excellent efficacy against Candida albicans in a murine infection model and the significantly improved survival rates of the infected mice.
authors: College of Pharmacy, Seoul National University, San 56-1 Shinrim-Dong, Kwanak-Gu, Seoul 151-742, Republic of Korea.
authors: Joon Seok
authors: JS
authors: Park
authors: Kyung A
authors: KA
authors: Yu
authors: Tae Hee
authors: TH
authors: Kang
authors: Sunghoon
authors: S
authors: Kim
authors: Young-Ger
authors: YG
authors: Suh
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000494:pharmacology* / Q000627:therapeutic use; D001230:Aspergillus / Q000187:drug effects* / Q000254:growth & development; D002175:Candida / Q000187:drug effects* / Q000254:growth & development; D004195:Disease Models, Animal; D007191:Indazoles / Q000138:chemical synthesis / Q000494:pharmacology* / Q000627:therapeutic use; D051379:Mice; D008826:Microbial Sensitivity Tests; D051381:Rats; D013237:Stereoisomerism; D014230:Triazoles / Q000138:chemical synthesis / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D000935:Antifungal Agents; D007191:Indazoles; D014230:Triazoles