Highway to the inner nuclear membrane: rules for the road.
To enter the nucleus a protein must be chaperoned by a transport factor through the nuclear pore complex or it must be small enough to pass through by diffusion. Although these principles have long described the nuclear import of soluble proteins, recent evidence indicates that they also apply to the import of integral inner nuclear membrane proteins. Here we develop a set of rules that might govern the transport of proteins to the inner nuclear membrane.
Lusk
C Patrick
CP
Laboratory of Cell Biology, Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.
Blobel
Günter
G
King
Megan C
MC
D021581:Active Transport, Cell Nucleus / Q000502:physiology*; D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism*; D006801:Humans; D028884:Karyopherins / Q000502:physiology; D008954:Models, Biological; D009685:Nuclear Envelope / Q000502:physiology*; D019913:Nuclear Localization Signals / Q000502:physiology; D022022:Nuclear Pore / Q000502:physiology; D028861:Nuclear Pore Complex Proteins / Q000502:physiology; D021381:Protein Transport / Q000502:physiology
D028884:Karyopherins; D019913:Nuclear Localization Signals; D028861:Nuclear Pore Complex Proteins