Extreme individual marker F(ST )values do not imply population-specific selection in humans: the NRG1 example.
Extreme population differentiation, as measured by the F(ST) value, has been suggested as an indicator of recent population-specific positive selection. Elevated F(ST) values indicating high differentiation between continental groups were previously reported on a linkage disequilibrium region in the Neuregulin 1 gene, a gene which has been associated to schizophrenia. In the present study we show evidence that high F(ST) values may not necessarily imply the action of selection, in particular positive selection, neither globally nor regionally, using the example of the NRG1 gene.
Gardner
Michelle
M
Unitat de Biologia Evolutiva, Universitat Pompeu Fabra, Doctor Aiguader 88, Barcelona, 08003, Spain.
Williamson
Scott
S
Casals
Ferran
F
Bosch
Elena
E
Navarro
Arcadi
A
Calafell
Francesc
F
Bertranpetit
Jaume
J
Comas
David
D
D000483:Alleles; D005787:Gene Frequency; D005819:Genetic Markers; D006801:Humans; D015810:Linkage Disequilibrium; D009419:Nerve Tissue Proteins / Q000235:genetics*; D020890:Neuregulin-1; D020641:Polymorphism, Single Nucleotide; D012641:Selection, Genetic
D005819:Genetic Markers; C094131:NRG1 protein, human; D009419:Nerve Tissue Proteins; D020890:Neuregulin-1