title: Modeling the relationship of cotinine and self-reported measures of maternal smoking during pregnancy: a deterministic approach.
abstract: Studies of effects of prenatal exposure to cigarettes frequently acquire both self-report and biological assays of maternal smoking. However, little attention has been paid to methods for combining information from both sources to enhance the precision of exposure measurement. This paper analyzes the relationship between the two commonly used measures of smoking exposure during pregnancy: Maternal self-report and urinary cotinine. We present a deterministic method for combining the two measures and examine its robustness under different assumptions. We apply the method to a dataset from the Family Health and Development Project. In addition, we propose an approach for calibrating the self-report measures for individual women based on both sources of information. Enhancing the quality of exposure measurement may substantially advance studies of the teratological effects of exposure on offspring.
authors: Department of Health Studies, University of Chicago, Chicago, IL 60637, USA. vanja@uchicago.edu
authors: Vanja M
authors: VM
authors: Dukic
authors: Marina
authors: M
authors: Niessner
authors: Neal
authors: N
authors: Benowitz
authors: Sydney
authors: S
authors: Hans
authors: Lauren
authors: L
authors: Wakschlag
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000652:urine; D003367:Cotinine / Q000652:urine*; D005260:Female; D006801:Humans; D018811:Maternal Exposure / Q000706:statistics & numerical data*; D009035:Mothers / Q000523:psychology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000517:prevention & control / Q000523:psychology / Q000652:urine*; D011295:Prenatal Care / Q000379:methods; D011446:Prospective Studies; D015203:Reproducibility of Results; D012650:Self Disclosure; D012647:Self-Assessment; D012907:Smoking / Q000523:psychology / Q000652:urine*; D000074606:Smoking Prevention; D011795:Surveys and Questionnaires; D014028:Tobacco Smoke Pollution / Q000032:analysis
chemical_list: D015415:Biomarkers; D014028:Tobacco Smoke Pollution; D003367:Cotinine