title: Regulation of Na+/Ca2+ exchange current in the normal and failing heart.
abstract: Cardiac NCX is modulated by diverse regulatory elements. Although there is consensus about the regulatory function of Na+ and Ca2+ and other elements, for example, ATP, there is still a controversial debate about the functional role of cyclic nucleotides and protein kinases. Future studies should focus on that topic since disturbances of cAMP/cGMP concentration and kinase activity may lead to severe functional disorders in the diseased heart. S100A1 is presumably a novel regulator of NCX.
authors: Institute of Neurophysiology, University of Cologne, D-50931 Cologne, Germany. akp72@uni-koeln.de
authors: Michael
authors: M
authors: Reppel
authors: Bernd K
authors: BK
authors: Fleischmann
authors: Hannes
authors: H
authors: Reuter
authors: Frank
authors: F
authors: Pillekamp
authors: Heribert
authors: H
authors: Schunkert
authors: Jürgen
authors: J
authors: Hescheler
mesh_terms: D002118:Calcium / Q000378:metabolism; D002303:Cardiac Output, Low / Q000503:physiopathology*; D002478:Cells, Cultured; D006321:Heart / Q000502:physiology*; D006801:Humans; D011494:Protein Kinases / Q000378:metabolism; D011943:Receptors, Adrenergic, beta / Q000502:physiology; D012964:Sodium / Q000378:metabolism; D019831:Sodium-Calcium Exchanger / Q000502:physiology*
chemical_list: D011943:Receptors, Adrenergic, beta; D019831:Sodium-Calcium Exchanger; D012964:Sodium; D011494:Protein Kinases; D002118:Calcium