Prediction of gastroesophageal reflux in otitis media with effusion in adults.
CONCLUSIONS
The measurement of pepsinogen I (PGI) in middle-ear effusions (MEEs) and a questionnaire on the frequency symptoms of gastroesophageal reflux (GER) disease are tools that can be used to screen for the existence of GER.


OBJECTIVE
To seek methods that would be beneficial as a screen for the presence of GER among adult patients with OME.


METHODS
Fifty-eight adult outpatients with OME were asked to answer a questionnaire of the frequency scale for symptoms of GER disease. Samples of MEEs were obtained from each subject and were measured for concentrations of PGI and PGII. Some patients were followed up after being treated with a proton pump inhibitor.


RESULTS
The percentage of patients with high PGI concentrations in their MEEs was higher in those with GER-related symptoms than in those without GER-related symptoms. Moreover, OME was present bilaterally in a higher percentage of patients with GER-related symptoms. There were patients in whom PGI levels decreased after receiving treatment for GER.
Sone
Michihiko
M
Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan. michsone@med.nagoya-u.ac.jp
Yamamuro
Yuri
Y
Hayashi
Hideo
H
Yanagi
Eriko
E
Niwa
Yasumasa
Y
Nakashima
Tsutomu
T
D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000897:Anti-Ulcer Agents / Q000627:therapeutic use; D004432:Ear, Middle / Q000737:chemistry; D005260:Female; D005764:Gastroesophageal Reflux / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D008297:Male; D008403:Mass Screening; D008875:Middle Aged; D010034:Otitis Media with Effusion / Q000175:diagnosis* / Q000209:etiology; D020116:Pepsinogen A / Q000032:analysis*; D020115:Pepsinogen C / Q000032:analysis*; D054328:Proton Pump Inhibitors; D064750:Rabeprazole; D012307:Risk Factors; D011795:Surveys and Questionnaires
D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D000897:Anti-Ulcer Agents; D054328:Proton Pump Inhibitors; D064750:Rabeprazole; D020115:Pepsinogen C; D020116:Pepsinogen A