Self-poisoning with lamotrigine and pregabalin.
We report a case of intentional overdose in a 29-year-old male with two of the newer anti-epileptic agents, lamotrigine and pregabalin. To our knowledge, this case report details the highest plasma levels of lamotrigine ever recorded in the literature. The patient presented with seizures and a reduced level of consciousness. Management of these and subsequent complications centres on supportive care in the high dependency and intensive therapy units.
Braga
A J
AJ
Department of Anaesthetics and Intensive Care, Gloucestershire Royal Hospital, Gloucester, UK. alicebraga@doctors.org.uk
Chidley
K
K
D000328:Adult; D000927:Anticonvulsants / Q000097:blood / Q000506:poisoning*; D062787:Drug Overdose; D006801:Humans; D000077213:Lamotrigine; D008297:Male; D000069583:Pregabalin; D012640:Seizures / Q000139:chemically induced* / Q000628:therapy; D013406:Suicide, Attempted; D014227:Triazines / Q000097:blood / Q000506:poisoning*; D014474:Unconsciousness / Q000139:chemically induced / Q000628:therapy; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000097:blood / Q000506:poisoning
D000927:Anticonvulsants; D014227:Triazines; D000069583:Pregabalin; D005680:gamma-Aminobutyric Acid; D000077213:Lamotrigine