title: Evaluation of candidate genes for DYX1 and DYX2 in families with dyslexia.
abstract: Dyslexia is a common heterogeneous disorder with a significant genetic component. Multiple studies have replicated the evidence for linkage between variously defined phenotypes of dyslexia and chromosomal regions on 15q21 (DYX1) and 6p22.2 (DYX2). Based on association studies and the possibility for functional significance of several polymorphisms, candidate genes responsible for the observed linkage signal have been proposed-DYX1C1 for 15q21, and KIAA0319 and DCDC2 for 6p22.2. We investigated the evidence for contribution of these candidate genes to dyslexia in our sample of multigenerational families. Our previous quantitative linkage analyses in this dataset provided supportive evidence for linkage of dyslexia to the locus on chromosome 15, but not to the locus on chromosome 6. In the current study, we used probands from 191 families for a case control analysis, and proband-parent trios for family-based TDT analyses. The observation of weak evidence for transmission disequilibrium for one of the two studied polymorphisms in DYX1C1 suggests involvement of this gene in dyslexia in our dataset. We did not find evidence for the association of KIAA0319 or DCDC2 alleles to dyslexia in our sample. We observed a slight tendency for an intronic deletion in DCDC2 to be associated with worse performance on some quantitative measures of dyslexia in the probands in our sample, but not in their parents.
authors: Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington 98198-7720, USA.
authors: Zoran
authors: Z
authors: Brkanac
authors: Nicola H
authors: NH
authors: Chapman
authors: Mark M
authors: MM
authors: Matsushita
authors: Lani
authors: L
authors: Chun
authors: Kathleen
authors: K
authors: Nielsen
authors: Elizabeth
authors: E
authors: Cochrane
authors: Virginia W
authors: VW
authors: Berninger
authors: Ellen M
authors: EM
authors: Wijsman
authors: Wendy H
authors: WH
authors: Raskind
mesh_terms: D000483:Alleles; D002648:Child; D002884:Chromosomes, Human, Pair 15 / Q000235:genetics*; D002896:Chromosomes, Human, Pair 6 / Q000235:genetics*; D003598:Cytoskeletal Proteins; D004410:Dyslexia / Q000235:genetics*; D005190:Family; D017353:Gene Deletion; D005838:Genotype; D006801:Humans; D008869:Microtubule-Associated Proteins / Q000235:genetics*; D009419:Nerve Tissue Proteins / Q000235:genetics*; D009687:Nuclear Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
chemical_list: D003598:Cytoskeletal Proteins; C510451:DCDC2 protein, human; C478878:DNAAF4 protein, human; C500377:KIAA0319 protein, human; D008869:Microtubule-Associated Proteins; D009419:Nerve Tissue Proteins; D009687:Nuclear Proteins