title: Anti-inflammatory and antinociceptive properties of blueberry extract (Vaccinium corymbosum).
abstract: Blueberries are among the edible fruits that are recognized best for their potential health benefits. The crude extract from Vaccinium corymbosum was assessed in anti-inflammatory and antinociceptive models. The crude hydroalcoholic extract was administered orally at doses of 100, 200 or 300 mg kg (-1) for all the assays. In the carrageenan test, the crude extract reduced rat paw oedema by 9.8, 28.5 and 65.9%, respectively. For the histamine assay, the reductions of oedema were 70.1, 71.7 and 81.9%, respectively. In the myeloperoxidase (MPO) assay, 300 mg kg (-1) crude extract produced a significant inhibition of the MPO activity, at 6 h and 24 h after injection of carrageenan, by 42.8 and 46.2%, respectively. With the granulomatous tissue assay dexamethasone displayed significant activity, whereas the blueberry extract was inactive. For the abdominal constriction test, inhibitions of 49.0, 54.5, 53.5%, respectively, were observed for the crude extract, and 61.4% for indometacin. In the formalin test, the crude extract (200 and 300 mg kg (-1)) and indometacin inhibited only the second phase by 36.2, 35.3 and 45.8%, respectively. Considering that the crude extract of blueberry displayed antinociceptive and anti-inflammatory activity, its consumption may be helpful for the treatment of inflammatory disorders.
authors: Núcleo de Ciência e Tecnologia, Area de Ciências Biológicas e da Saúde, Universidade do Oeste de Santa Catarina, Campus de Videira, Rua Paese, 198, Bairro das Torres, Videira-SC, 89560-000, SC, Brazil.
authors: Eliane
authors: E
authors: Torri
authors: Marivane
authors: M
authors: Lemos
authors: Vinícius
authors: V
authors: Caliari
authors: Cândida A L
authors: CA
authors: Kassuya
authors: Jairo K
authors: JK
authors: Bastos
authors: Sérgio F
authors: SF
authors: Andrade
mesh_terms: D000005:Abdomen; D000700:Analgesics / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000494:pharmacology*; D002351:Carrageenan; D003251:Constriction, Pathologic / Q000139:chemically induced / Q000188:drug therapy; D003907:Dexamethasone / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy*; D005638:Fruit; D015745:Granuloma, Foreign-Body / Q000188:drug therapy; D006632:Histamine / Q000502:physiology; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D010147:Pain Measurement; D009195:Peroxidase / Q000187:drug effects / Q000378:metabolism; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D029796:Vaccinium
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D003907:Dexamethasone; D006632:Histamine; D002351:Carrageenan; D009195:Peroxidase; D007213:Indomethacin