[Survivin expression in ovarian germ cell tumors].
OBJECTIVE
To investigate the relationship between the expression of survivin and the development of ovarian germ cell tumors (OGCT).


METHODS
Survivin expressions in normal ovaries (n = 10) and ovarian germ cell tumors (n = 29) were detected with labelled streptavidin biotin method.


RESULTS
No survivin protein was expressed in normal ovaries. Survivin protein was found in the cytoplasm and/or the nuclear of cells of 58.6% (17/29) of the ovarian germ cell tumor samples (P < 0.05). There was no significant correlations between surviving protein and the pathologic types, stage, lymphonode metastasis, AFP and volume of ascites of the tumors (P > 0.05).


CONCLUSIONS
High expression of survivin protein may trigger the pathogenesis of the ovarian germ cell tumors.
Yin
Ru-Tie
RT
Department of Obstetrics and Gynecology, West China Second Hospital, Sichuan University, Chengdu 610041, China.
Peng
Zhi-Lan
ZL
Yang
Kai-Xuan
KX
Kang
De-Ying
DY
D001201:Ascites / Q000150:complications; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins; D008207:Lymphatic Metastasis / Q000235:genetics; D008869:Microtubule-Associated Proteins / Q000378:metabolism*; D008875:Middle Aged; D009367:Neoplasm Staging; D009373:Neoplasms, Germ Cell and Embryonal / Q000150:complications / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D010051:Ovarian Neoplasms / Q000150:complications / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D000077022:Survivin; D055815:Young Adult; D000509:alpha-Fetoproteins / Q000378:metabolism
C107489:BIRC5 protein, human; D051034:Inhibitor of Apoptosis Proteins; D008869:Microtubule-Associated Proteins; D000077022:Survivin; D000509:alpha-Fetoproteins