title: Bendiocarbamate induced structural alterations in rabbit thymus after experimental peroral administration.
abstract: In this study histological structure of rabbit thymus after bendiocarbamate (2,3-isopropyledene-dioxyphenyl methylcarbamate) administration was studied. Bendiocarbamate was perorally administered for 90 days. At Day 3, 10, 20, 30, 60, 90 morphometric analysis was realized. Quantitative evaluation showed that in the control group thymus cortex forms 57.94 +/- 7.10% and medulla 35.94+/- 7.38%. In almost all experimental groups significantly higher relative volume of cortex and lower relative volume of medulla was detected. Detail morphometric analysis found that the number of thymocytes per constant area and the diameter of tymocytes was decresed after bendiocarbamate administration. The number and diameter of reticular cells was not affected. Results of this study suggest negative effect of bendiocarbamate on the formation of thymus structures.
authors: Department of Anatomy, Histology and Physiology, University of Veterinary Medicine, Kosice, Slovak Republic.
authors: Slavka
authors: S
authors: Flesarova
authors: Norbert
authors: N
authors: Lukac
authors: Jan
authors: J
authors: Danko
authors: Peter
authors: P
authors: Massanyi
mesh_terms: D000284:Administration, Oral; D000818:Animals; D005260:Female; D007150:Immunohistochemistry; D007306:Insecticides / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D048448:Phenylcarbamates / Q000008:administration & dosage / Q000494:pharmacology*; D011817:Rabbits; D011897:Random Allocation; D013950:Thymus Gland / Q000033:anatomy & histology / Q000166:cytology / Q000187:drug effects* / Q000473:pathology; D013997:Time Factors
chemical_list: D007306:Insecticides; D048448:Phenylcarbamates; C007725:bendiocarb