Canine DLA diversity: 3. Disease studies.
There are many millions of dogs worldwide, and these dogs have many different functions. The most obvious use is providing companionship, but there are also many working dogs, including guide dogs for the blind, hearing dogs, guard dogs and farm dogs, to mention a few. The health and welfare of these dogs is of great concern to dog owners, dog breeders and to those who use dogs in their work. Dogs spontaneously develop many diseases that are very similar to their human counterparts. Dogs may, therefore, provide exceptional animal models for such diseases. Identifying genetic markers in the dog may be easier than in humans, and may then provide useful information about genes that can be transferred to humans. This study looked for associations between DLA and two autoimmune diseases of the dog, diabetes and hypothyroidism. DLA associations were found for both of these diseases.
Kennedy
L J
LJ
Centre for Integrated Genomic Medical Research, University of Manchester, Manchester, UK. Lorna.Kennedy@manchester.ac.uk
Barnes
A
A
Short
A
A
Brown
J J
JJ
Seddon
J
J
Fleeman
L
L
Brkljacic
M
M
Happ
G M
GM
Catchpole
B
B
Ollier
W E R
WE
D000818:Animals; D003920:Diabetes Mellitus / Q000235:genetics / Q000276:immunology / Q000662:veterinary*; D004283:Dog Diseases / Q000235:genetics* / Q000276:immunology; D004285:Dogs; D005838:Genotype; D006239:Haplotypes; D007037:Hypothyroidism / Q000235:genetics / Q000276:immunology / Q000662:veterinary*; D012307:Risk Factors