title: CYP1B1 and predisposition to breast cancer in Poland.
abstract: BACKGROUND
  The CYP1B1 gene is a polymorphic member of the P450 gene family and is considered to be a candidate gene for cancers of various types.
  
  
  OBJECTIVE
  We inquired whether four SNPs in the CYP1B1 gene, alone or in combination, might be associated with breast cancer risk in Poland.
  
  
  METHODS
  We genotyped 2017 cases of breast cancer and 876 controls, for four SNPs in the CYP1B1 gene. Genotype and haplotype frequencies were compared in cases and controls.
  
  
  RESULTS
  In combinations of the R48G, A119S and L432V SNPs, four of the eight CYP1B1 haplotypes were more common in controls than in cases and each of these appeared to have a significant protective effect. A large reduction in risk was observed for women who were homozygous for one of these four haplotypes (OR = 0.2; 95%; CI = 0.05-0.5; P = 0.001) compared to women who were homozygous for the most common haplotype. In contrast, women who were homozygous for the GTC haplotype were at increased risk (OR = 1.5; 95%; CI = 1.0-2.1; P = 0.03) compared to women with the most common haplotype.
  
  
  CONCLUSIONS
  The CYP1B1 gene appears to influence breast cancer susceptibility in Poland.
authors: Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, Szczecin, Poland.
authors: Joanna
authors: J
authors: Matyjasik
authors: Cezary
authors: C
authors: Cybulski
authors: Bartlomiej
authors: B
authors: Masojć
authors: Anna
authors: A
authors: Jakubowska
authors: Pablo
authors: P
authors: Serrano-Fernandez
authors: Bohdan
authors: B
authors: Górski
authors: Tadeusz
authors: T
authors: Debniak
authors: Tomasz
authors: T
authors: Huzarski
authors: Tomasz
authors: T
authors: Byrski
authors: Jacek
authors: J
authors: Gronwald
authors: Elzbieta
authors: E
authors: Złowocka
authors: Steven Alexander
authors: SA
authors: Narod
authors: Rodney
authors: R
authors: Scott
authors: Jan
authors: J
authors: Lubinski
mesh_terms: D001189:Aryl Hydrocarbon Hydroxylases; D001943:Breast Neoplasms / Q000201:enzymology / Q000235:genetics*; D065633:Cytochrome P-450 CYP1B1; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D011044:Poland; D020641:Polymorphism, Single Nucleotide
chemical_list: D003577:Cytochrome P-450 Enzyme System; D001189:Aryl Hydrocarbon Hydroxylases; C585496:CYP1B1 protein, human; D065633:Cytochrome P-450 CYP1B1