miR-1-2 gets to the heart of the matter.
Although many microRNAs (miRNAs) and their targets have been identified, the importance of miRNAs in vivo is still unclear. In this issue, Zhao et al. (2007) generate mice deficient in a cardiac-specific miRNA, miR-1-2, and reveal that this microRNA plays a crucial role in heart development and physiology.
Mishima
Yuichiro
Y
Department of Genetics, Yale University School of Medicine, New Haven, CT 06510, USA.
Stahlhut
Carlos
C
Giraldez
Antonio J
AJ
D000818:Animals; D006321:Heart / Q000196:embryology* / Q000502:physiology*; D051379:Mice; D035683:MicroRNAs / Q000235:genetics / Q000502:physiology*
D035683:MicroRNAs