Chondroprotective potential of root extracts of Withania somnifera in osteoarthritis.
This is the first report describing two novel chondroprotective activities of aqueous extracts of Withania somnifera root powder.First,these extracts had a statistically significant,short-term chondroprotective effect on damaged human osteoarthritic cartilage matrix in 50% of the patients tested. Second,these extracts caused a significant and reproducible inhibition of the gelatinase activity of collagenase type 2 enzyme in vitro.
Sumantran
Venil N
VN
Interactive Research School for Health Affairs (IRSHA), Bhartiya Vidyapeeth Deemed University Medical College Campus, Dhankawadi, Pune 411043, India. vsumantran@gmail.com
Kulkarni
Asavari
A
Boddul
Sanjay
S
Chinchwade
Trushna
T
Koppikar
Soumya J
SJ
Harsulkar
Abhay
A
Patwardhan
Bhushan
B
Chopra
Arvind
A
Wagh
Ulhas V
UV
D000368:Aged; D064236:Cartilage Oligomeric Matrix Protein; D016326:Extracellular Matrix Proteins / Q000378:metabolism; D006023:Glycoproteins / Q000378:metabolism; D006801:Humans; D064235:Matrilin Proteins; D020784:Matrix Metalloproteinase 8 / Q000378:metabolism; D008875:Middle Aged; D010003:Osteoarthritis / Q000188:drug therapy*; D008517:Phytotherapy / Q000379:methods*; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D018517:Plant Roots / Q000737:chemistry*; D011509:Proteoglycans / Q000378:metabolism; D013053:Spectrophotometry; D013997:Time Factors; D032341:Withania / Q000737:chemistry*
D064236:Cartilage Oligomeric Matrix Protein; D016326:Extracellular Matrix Proteins; D006023:Glycoproteins; D064235:Matrilin Proteins; D010936:Plant Extracts; D011509:Proteoglycans; C577553:TSP5 protein, human; D020784:Matrix Metalloproteinase 8