title: Evaluation by optical coherence tomography of neointimal coverage of sirolimus-eluting stent three months after implantation.
abstract: Confirming complete neointimal coverage after implantation of a drug-eluting stent is clinically important because incomplete stent coverage is responsible for late thrombosis and sudden cardiac death. Optical coherence tomography is a high-resolution (approximately 10 microm) imaging technique capable of detecting a thin layer of neointimal hyperplasia (NIH) inside a sirolimus-eluting stent (SES) and stent malapposition. This investigation evaluated stent exposure and malapposition 3 months after SES implantation using optical coherence tomography in a different clinical presentations, such as acute coronary syndrome (ACS) and non-ACS. Motorized optical coherence tomographic pullback (1 mm/s) was performed at 3-month follow-up to examine consecutive implanted 31 SESs in 21 lesions in 21 patients (9 with ACS and 12 with non-ACS). NIH thickness inside each strut and percent NIH area in each cross section were measured. In total, 4,516 struts in 567-mm single-stented segments were analyzed. Overall, NIH thickness and percent NIH area were 29 +/- 41 microm and 10 +/- 4%, respectively. Rates of exposed struts and exposed struts with malapposition were 15% and 6%, respectively. These were more frequent in patients with ACS than in those with non-ACS (18% vs 13%, p <0.0001; 8% vs 5%, p <0.005, respectively). In conclusion, neointimal coverage over a SES at 3-month follow-up is incomplete in ACS and non-ACS. Our study suggests that dual antiplatelet therapy might be continued >3 months after SES implantation.
authors: Department of Internal Medicine, Chiba-Hokusoh Hospital, Nippon Medical School, Chiba, Japan. takanom@nms.ac.jp
authors: Masamichi
authors: M
authors: Takano
authors: Shigenobu
authors: S
authors: Inami
authors: Ik-Kyung
authors: IK
authors: Jang
authors: Masanori
authors: M
authors: Yamamoto
authors: Daisuke
authors: D
authors: Murakami
authors: Koji
authors: K
authors: Seimiya
authors: Takayoshi
authors: T
authors: Ohba
authors: Kyoichi
authors: K
authors: Mizuno
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019412:Anatomy, Cross-Sectional; D000789:Angina, Unstable / Q000628:therapy; D015906:Angioplasty, Balloon, Coronary; D017023:Coronary Angiography; D003327:Coronary Disease / Q000175:diagnosis; D023903:Coronary Restenosis / Q000175:diagnosis; D005343:Fibrinolytic Agents / Q000008:administration & dosage*; D005500:Follow-Up Studies; D005548:Foreign-Body Migration / Q000175:diagnosis; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000628:therapy; D012189:Retrospective Studies; D020123:Sirolimus / Q000008:administration & dosage*; D015607:Stents; D013499:Surface Properties; D041623:Tomography, Optical Coherence; D017539:Tunica Intima / Q000187:drug effects / Q000473:pathology*
chemical_list: D005343:Fibrinolytic Agents; D020123:Sirolimus