title: Easily accessible benzamide-derived P,O ligands (Bphos) for palladium-catalyzed carbon-nitrogen bond-forming reactions.
abstract: Easily accessible benzamide-derived hemilabile phosphine ligands were efficiently prepared through ortho-directed lithiation of the corresponding N,N-diethylbenzamide followed by quenching with chlorodialkylphosphines. These structurally simple hemilabile ligands were found to be highly effective in palladium-catalyzed amination of aryl and heteroaryl chlorides. Various sterically congested and functionalized aryl halide substrates were compatible in these reaction conditions. By using optimized reaction conditions, remarkable catalyst productivity (total turnover number up to 8400) was obtained.
authors: State Key Laboratory of Chinese Medicine and Molecular Pharmacology, Shenzhen, China.
authors: Guoshu
authors: G
authors: Chen
authors: Wai Har
authors: WH
authors: Lam
authors: Wai Shan
authors: WS
authors: Fok
authors: Hang Wai
authors: HW
authors: Lee
authors: Fuk Yee
authors: FY
authors: Kwong
mesh_terms: D000586:Amination; D001549:Benzamides / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D010165:Palladium / Q000737:chemistry; D010720:Phosphines / Q000138:chemical synthesis*
chemical_list: D001549:Benzamides; D010720:Phosphines; D010165:Palladium