[Hepcidin and iron metabolism].
BACKGROUND
In mammals, iron balance is maintained by regulating intestinal iron absorption and iron recycling by macrophages.


METHODS
The central role of hepcidin in the establishment of iron deficiency or overload has been revealed by the study of murine models.


CONCLUSIONS
Many hopes have emerged from the discovery of hepcidin, pointing to potential treatments for hemochromatosis and anemia of inflammation (anemia of chronic disease).
Delaby
C
C
Institut National de Santé et de la Recherche Médicale (Inserm) U773, Centre de Recherche Biomédicale Bichat-Beaujon CRB3, Université Paris-VII Denis-Diderot, 75870 Paris cedex 18, France. delaby@bichat.inserm.fr
Deybach
J-C
JC
Beaumont
C
C
D000818:Animals; D023181:Antimicrobial Cationic Peptides / Q000097:blood / Q000378:metabolism*; D064451:Hepcidins; D006706:Homeostasis; D006801:Humans; D007408:Intestinal Absorption; D007501:Iron / Q000097:blood / Q000378:metabolism*; D008264:Macrophages / Q000378:metabolism; D008322:Mammals
D023181:Antimicrobial Cationic Peptides; C578702:HAMP protein, human; D064451:Hepcidins; D007501:Iron