title: [Botulinum toxin A injection for treatment-refractory giggle incontinence].
abstract: A 20-year-old woman reported about giggle incontinence despite antimuscarinic therapy. Therefore we injected botulinum toxin A into the detrusor muscle. The effect of botulinum toxin A appeared about 1 week after injection and no more leakage was observed even during vigorous laughter. A control uroflowmetry showed a good voiding rate without any residual volume. Botulinum toxin A might be an alternative for patients with giggle incontinence after unsuccessful antimuscarinic treatment.
authors: Klinik für Urologie und Kinderurologie, Universitätsklinikum Schleswig-Holstein, Campus Kiel, 24105, Kiel. bwefer@urology.uni-kiel.de
authors: B
authors: B
authors: Wefer
authors: C
authors: C
authors: Seif
authors: C
authors: C
authors: van der Horst
authors: K P
authors: KP
authors: Jünemann
authors: P M
authors: PM
authors: Braun
mesh_terms: D000328:Adult; D019274:Botulinum Toxins, Type A / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D007845:Laughter; D018727:Muscarinic Antagonists / Q000008:administration & dosage*; D017211:Treatment Failure; D016896:Treatment Outcome; D014549:Urinary Incontinence / Q000188:drug therapy*
chemical_list: D018727:Muscarinic Antagonists; D019274:Botulinum Toxins, Type A