title: Age-related changes in skeletal muscle as detected by diffusion tensor magnetic resonance imaging.
abstract: BACKGROUND
  Loss of muscle mass and strength is a common symptom in the elderly population. This is partly a result of the structural changes that occur during the aging process. We applied diffusion tensor magnetic resonance imaging (DTMRI) to determine if water diffusivity in skeletal muscle changes with age.
  
  
  METHODS
  Thirty-eight healthy men, ranging from 27 to 67 years of age, were recruited for this study. The total population was grouped by age (Young < mean age 46.4: n = 20; Old > or = mean age 46.4: n = 18) and body mass index (BMI; Normal < 25: n = 20; Over > or =25: n = 18). The principal, second, and third eigenvalues (lambda(1) > or = lambda(2) > or = lambda(3)), and fractional anisotropy (FA), were calculated from the diffusion tensor of the soleus, lateral and medial gastrocnemius, and anterior tibialis (AT). Analyses included comparison of groups and linear regressions.
  
  
  RESULTS
  The older adults showed a significant reduction in the eigenvalues of the plantar flexors ( approximately 7%, p <.05) and FA of AT ( approximately 10%, p <.05) from that of the younger adults. No age differences were observed in the FA of the plantar flexors or eigenvalues of AT. lambda(1) and lambda(2) had a linear dependence on age in the plantar flexors, whereas AT showed age dependence in lambda(3) and FA.
  
  
  CONCLUSIONS
  We demonstrated that DTMRI is sensitive to age-related changes in muscle, and that the effects of aging differ between the plantar flexors and AT.
authors: Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital of Essen, Germany. cgalban@umich.edu
authors: Craig J
authors: CJ
authors: Galbán
authors: Stefan
authors: S
authors: Maderwald
authors: Frank
authors: F
authors: Stock
authors: Mark E
authors: ME
authors: Ladd
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology*; D016880:Anisotropy; D038524:Diffusion Magnetic Resonance Imaging; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000502:physiology*; D012680:Sensitivity and Specificity