title: Association in alcoholic patients between psychopathic traits and the additive effect of allelic forms of the CNR1 and FAAH endocannabinoid genes, and the 3' region of the DRD2 gene.
abstract: Little is known about the genetic factors that underlie the comorbidity between alcohol use disorder and antisocial personality disorder. Previous studies have associated both, dopaminergic and endocannabinoid systems to severe alcoholism with non-adaptive disrupted behaviours. In this work we have examined some gene variants involved in such systems in a sample of alcoholic patients to test whether there is a relationship with antisocial traits. The genetic analysis involved the genotyping of the single nucleotide polymorphism (SNP) TaqIA located nearby the DRD2 gene, the 10-repeat allele of a variable number tandem repeats (VNTR) of the SLC6A3 gene, the C385A FAAH SNP and the 3'-UTR microsatellite of CNR1 gene. The clinical study was performed in 137 Spanish alcohol dependent males. Antisocial Personality Disorder (DSM-IV) diagnosis was made by applying the International Personality Disorder Examination, and psychopathic traits were evaluated by the Hare's Psychopathy Checklist revised (PCL-R). The genotype distribution indicates there is a relationship between the TaqIA SNP, CNR1 and FAAH genes and PCL-R's Factor 1 in alcoholic patients. This relationship seems to be additive and independent and might be responsible for 11.4% of the variance in this PCL-R subscale. Our results suggest the implication of the dopaminergic and endocannabinoid systems in those processes leading to the comorbidity of alcoholism and antisocial behaviour.
authors: Unidad de conductas adictivas, Servicio de Psiquiatría, Hospital Universitario 12 de Octubre., Av. de Córdoba, Madrid 28041, Spain.
authors: Janet
authors: J
authors: Hoenicka
authors: Guillermo
authors: G
authors: Ponce
authors: Miguel A
authors: MA
authors: Jiménez-Arriero
authors: Israel
authors: I
authors: Ampuero
authors: Roberto
authors: R
authors: Rodríguez-Jiménez
authors: Gabriel
authors: G
authors: Rubio
authors: Maria
authors: M
authors: Aragüés
authors: Jose A
authors: JA
authors: Ramos
authors: Tomás
authors: T
authors: Palomo
mesh_terms: D020413:3' Untranslated Regions / Q000235:genetics; D000293:Adolescent; D000328:Adult; D000368:Aged; D000437:Alcoholism / Q000453:epidemiology / Q000235:genetics* / Q000523:psychology*; D000483:Alleles; D000581:Amidohydrolases / Q000235:genetics*; D000987:Antisocial Personality Disorder / Q000453:epidemiology / Q000235:genetics* / Q000523:psychology*; D004247:DNA / Q000235:genetics; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D018598:Minisatellite Repeats; D018807:Polymorphism, Single-Stranded Conformational; D011569:Psychiatric Status Rating Scales; D043884:Receptor, Cannabinoid, CB1 / Q000235:genetics*; D017448:Receptors, Dopamine D2 / Q000235:genetics*; D013030:Spain / Q000453:epidemiology; D000099252:Fatty Acid Amide Hydrolases
chemical_list: D020413:3' Untranslated Regions; D000581:Amidohydrolases; D004247:DNA; D043884:Receptor, Cannabinoid, CB1; D017448:Receptors, Dopamine D2; D000099252:Fatty Acid Amide Hydrolases