The ghrelin system: physiopathological involvement in the control of body growth and energy metabolism.
This short review will summarize some recent findings on the physiopathology of the endogenous ghrelin/obestatin system by focussing on experimental studies aiming at blocking the effects of endogenous ghrelin and clinical studies investigating genotype/phenotype correlations concerning the genes encoding for ghrelin and its cognate receptor.
Epelbaum
Jacques
J
UMR 549 Inserm Université Paris-Descartes IFR 77, Centre Paul Broca de l'INSERM, 2 ter rue d'Alésia, 75014, Paris, France. jacques.epelbaum@broca.inserm.fr
D000818:Animals; D049628:Body Size; D004734:Energy Metabolism; D005838:Genotype; D054439:Ghrelin; D006128:Growth; D006801:Humans; D009154:Mutation; D036361:Peptide Hormones / Q000235:genetics* / Q000378:metabolism*; D010641:Phenotype; D043562:Receptors, G-Protein-Coupled / Q000037:antagonists & inhibitors* / Q000235:genetics; D054440:Receptors, Ghrelin
D054439:Ghrelin; D036361:Peptide Hormones; D043562:Receptors, G-Protein-Coupled; D054440:Receptors, Ghrelin; C505799:obestatin, human; C512328:obestatin, mouse; C505798:obestatin, rat