Graft versus leukemia effect against juvenile myelomonocytic leukemia after unrelated cord blood transplantation.
A 13-month-old female underwent unrelated cord blood transplantation (CBT) for juvenile myelomonocytic leukemia (JMML). In spite of progression of the disease after a conditioning regimen with high-dose chemotherapy, a complete remission was induced in concordance with development of acute GVHD after reduction of the immunosupressant. She has been in complete remission for 1 year after transplantation. This case illustrates that CBT can provide a potent graft versus leukemia (GVL) effect against JMML.
Tanoshima
Reo
R
Department of Pediatrics, Yokohama City University, Yokohama, Kanagawa, Japan.
Goto
Hiroaki
H
Yanagimachi
Masakatsu
M
Kajiwara
Ryosuke
R
Kuroki
Fumiko
F
Yokota
Shumpei
S
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003131:Combined Modality Therapy; D036101:Cord Blood Stem Cell Transplantation; D016572:Cyclosporine / Q000627:therapeutic use; D004200:Diseases in Twins; D005260:Female; D006086:Graft vs Host Disease / Q000209:etiology; D020544:Graft vs Leukemia Effect; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007223:Infant; D054429:Leukemia, Myelomonocytic, Juvenile / Q000188:drug therapy / Q000601:surgery*; D008297:Male; D012074:Remission Induction
D007166:Immunosuppressive Agents; D016572:Cyclosporine