title: [HIV-1 molecular epidemiological survey of drug users in Jiangxi province].
abstract: OBJECTIVE
  To investigate HIV-1 molecular epidemiology of drug users in Jiangxi Province to analyze epidemic situation, subtype, origin of strain, and variation, and to provide information for prevention and control of AIDS.
  
  
  METHODS
  Combining principles of traditional epidemiology and molecular epidemiology, the authors analyzed the epidemiologically related factors, the gene sequences and systematic mutation of HIV-1 gene in nine drug users in Jiangxi province.
  
  
  RESULTS
  The HIV spread through the drug users in Jiangxi not only by injection but also by sexual contacts. The main epidemic strain found by sequence analysis was HIV-1 CRF01-AE that was closely related to the strain among drug users in Vietnam and Guangxi Zhuang Autonomous Region, with the average gene distance of 9.00 +/- 2.27 from the Vietnam strain. The origin of strain among drug users in the province was entirely the same.
  
  
  CONCLUSIONS
  At present, HIV-1 CRF01-AE strain has spread in the whole province among the drug users. Vigorous behavioral interventions should be developed in drug users and un-safe sexual behavior population to prevent the epidemic.
authors: Jiangxi Center for Disease Control and Prevention, Nanchang 330029, China. Yi_zhiqi@yahoo.com.cn
authors: Zhi-qiang
authors: ZQ
authors: Yi
authors: Hui
authors: H
authors: Xing
authors: Guo-liang
authors: GL
authors: Hu
authors: Min
authors: M
authors: Wei
authors: Xiao-feng
authors: XF
authors: Zhou
authors: Hao
authors: H
authors: Liang
authors: Xiao-ming
authors: XM
authors: Jiang
authors: Fei-bao
authors: FB
authors: Lu
authors: Hong
authors: H
authors: Chen
authors: Yi-ming
authors: YM
authors: Shao
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000453:epidemiology / Q000821:virology*; D000328:Adult; D002681:China / Q000453:epidemiology; D004279:DNA, Viral / Q000737:chemistry / Q000235:genetics; D004196:Disease Outbreaks / Q000517:prevention & control; D014644:Genetic Variation; D015497:HIV-1 / Q000145:classification / Q000235:genetics*; D006801:Humans; D008297:Male; D017720:Molecular Epidemiology; D017422:Sequence Analysis, DNA; D015819:Substance Abuse, Intravenous / Q000453:epidemiology / Q000821:virology*
chemical_list: D004279:DNA, Viral