Computerized gait analysis of botulinum toxin treatment in children with cerebral palsy.
OBJECTIVE
Intramuscular botulinum toxin A (BTA) injection is a local reversible treatment with a wide range of therapeutic applications, including temporary reduction of spasticity. The aim of this work was a quantitative, computerized objective evaluation of BTA-induced improvement of the walking functional ability in a group of children with cerebral palsy (CP).


METHODS
Fifteen children with CP and 20 healthy children were evaluated. All patients were equinus walkers without fixed contractures of triceps surae muscles and they were evaluated before and after about 1.5 months from BTA injections into the calf muscles. The effectiveness of treatment was evaluated by 3D computerized gait analysis.


RESULTS
Data analysis revealed a significant improvement of equinus foot and ankle range of motion during gait after BTA injection. Positive effects were evident also at the knee joint as documented by the improvement of kinetics characteristics (moment and power).


CONCLUSIONS
Computerized gait analysis is a valid method for quantification of BTA effect on walking in children with CP, allowing a detailed evaluation of improvement at each joint and a quantitative evaluation of treatment outcome.
Galli
Manuela
M
Dipartimento di Bioingegneria, Politecnico di Milano, Milano, Italy. manuela.galli@biomed.polimi.it
Cimolin
Veronica
V
Valente
Enza Maria
EM
Crivellini
Marcello
M
Ialongo
Tamara
T
Albertini
Giorgio
G
D000843:Ankle Joint / Q000502:physiology; D018726:Anti-Dyskinesia Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001696:Biomechanical Phenomena; D019274:Botulinum Toxins, Type A / Q000494:pharmacology / Q000627:therapeutic use*; D016022:Case-Control Studies; D002547:Cerebral Palsy / Q000188:drug therapy*; D002648:Child; D002675:Child, Preschool; D005684:Gait / Q000187:drug effects*; D006621:Hip Joint / Q000502:physiology; D006801:Humans; D021621:Imaging, Three-Dimensional; D007719:Knee Joint / Q000502:physiology; D009128:Muscle Spasticity / Q000188:drug therapy
D018726:Anti-Dyskinesia Agents; D019274:Botulinum Toxins, Type A