Influence of killer cell immunoglobulin-like receptor genotypes on acute graft-vs-host disease after unrelated hematopoietic stem cell transplantation in Koreans.
Interactions between killer cell immunoglobulin-like receptors (KIRs) and human leukocyte antigen class I ligands influence the development of the natural killer cell repertoire and the responses to infection, cancer, and allogeneic tissue. In this study, the association of KIR genes with acute graft-vs-host disease (GVHD) was investigated in 44 pairs of leukemia patients and their unrelated donors for hematopoietic stem cell transplantation (HSCT). Donors with more than 12 KIR genes showed significantly decreased frequencies of severe acute GVHD compared with donors with less than 11 KIR genes (P < 0.05). The distribution of KIR genotypes was not different between severe and mild acute GVHD in patients and donors, respectively. These results suggest that the number of KIR genes in donors could influence the occurrence of acute GVHD after unrelated HSCT.
Kim
S-Y
SY
Department of Microbiology and Immunology, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
Choi
H-B
HB
Yoon
H-Y
HY
Choi
E-J
EJ
Cho
B
B
Kim
H-K
HK
Kim
Y-J
YJ
Kim
H-J
HJ
Min
C-K
CK
Kim
D-W
DW
Lee
J-W
JW
Min
W-S
WS
Kim
C-C
CC
Kim
T-G
TG
D000208:Acute Disease; D006086:Graft vs Host Disease / Q000209:etiology*; D020544:Graft vs Leukemia Effect; D015236:HLA-C Antigens / Q000502:physiology; D018380:Hematopoietic Stem Cell Transplantation; D006650:Histocompatibility Testing; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D007723:Korea; D007938:Leukemia / Q000150:complications / Q000276:immunology / Q000628:therapy*; D011971:Receptors, Immunologic / Q000235:genetics* / Q000276:immunology; D054340:Receptors, KIR; D014019:Tissue Donors
D015236:HLA-C Antigens; D011971:Receptors, Immunologic; D054340:Receptors, KIR