[Antineutrophil cytoplasmic antibody (Anca)-associated autoimmune disease induced by propylthiouracil].
Antithyroid drugs sometimes cause severe complications. Propylthiouracil (PTU) can be associated to ANCA positive vasculitis, most often related to myeloperoxidase subtype (ANCA-MPO). Our objective is to describe a female patient with Graves' disease, who developed PTU induced-autoimmune disease, with cutaneous, pulmonary, and renal lesions, associated with ANCA. Histopathological examination revealed diffuse pulmonary hemorrhage, and focal segmental glomerulosclerosis at the kidney biopsy. She was treated with systemic corticosteroid therapy and cyclophosphamide, with clinical improvement. This case highlights the need for greater awareness of this relatively rare adverse effect of propylthiouracil.
Pietszkowski
Nádila Cecyn
NC
Serviço de Endocrinologia e Metabologia, Universidade Federal do Paraná, Curitiba, PR.
Carvalho
Gisah Amaral de
GA
Souza
Hevelyn Noemberg de
HN
Werka
Cláudio Rogério
CR
Borazo
Luís Augusto
LA
Graf
Hans
H
Carvalho
Mauricio de
Md
D000328:Adult; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood*; D013956:Antithyroid Agents / Q000009:adverse effects*; D001327:Autoimmune Diseases / Q000139:chemically induced* / Q000276:immunology; D005260:Female; D006111:Graves Disease / Q000188:drug therapy / Q000276:immunology; D006801:Humans; D007155:Immunologic Factors / Q000276:immunology; D009195:Peroxidase / Q000276:immunology*; D011441:Propylthiouracil / Q000009:adverse effects*; D014657:Vasculitis / Q000139:chemically induced* / Q000276:immunology
D019268:Antibodies, Antineutrophil Cytoplasmic; D013956:Antithyroid Agents; D007155:Immunologic Factors; D011441:Propylthiouracil; D009195:Peroxidase