Renal cell carcinoma marker (RCC-Ma) is specific for cutaneous metastasis of renal cell carcinoma.
BACKGROUND
Renal cell carcinoma marker (RCC-Ma) is a monoclonal antibody against a normal renal proximal tubule antigen. RCC-Ma expression is relatively specific for primary clear cell renal cell carcinoma. Its expression in cutaneous metastasis of renal cell carcinoma (MRCC) and other cutaneous clear cell lesions has not been studied.


METHODS
One hundred and thirty-seven cutaneous clear cell lesions including eight xanthomas, 32 xanthelasmas, 25 xanthogranulomas, seven balloon cell nevi, six clear cell hidradenomas, 29 sebaceous adenomas, six sebaceous epitheliomas, eight sebaceous carcinomas, and 16 MRCC were examined using immunohistochemistry for the expression of RCC-Ma.


RESULTS
RCC-Ma was expressed in 10 of 16 (62.5%) MRCC, all with greater than 20% of cell labeling. Of these, 4 of 10 (40%) labeled with a membranous pattern and 6 of 10 (60%) labeled with both a membranous and a cytoplasmic pattern. RCC expression was not seen in any of the other clear cell lesions (p < 0.001). Furthermore, lack of expression in each of the other diagnostic groups was significant when each group was compared with the MRCCs (p < 0.01 at least for each group).


CONCLUSIONS
Our study demonstrates that RCC may be a valuable component of a panel of immunohistochemical markers when evaluating cutaneous clear cell lesions.
Perna
Ashley G
AG
Department of Pathology, Baylor College of Medicine, Houston, TX 77030, USA. ap692395@bcm.tmc.edu
Ostler
Daniel A
DA
Ivan
Doina
D
Lazar
Alexander J F
AJ
Diwan
A Hafeez
AH
Prieto
Victor G
VG
Reed
Jon A
JA
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000911:Antibodies, Monoclonal; D014408:Biomarkers, Tumor / Q000032:analysis*; D002292:Carcinoma, Renal Cell / Q000378:metabolism / Q000556:secondary*; D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D007680:Kidney Neoplasms / Q000378:metabolism / Q000473:pathology*; D008875:Middle Aged; D012878:Skin Neoplasms / Q000378:metabolism / Q000556:secondary*
D000911:Antibodies, Monoclonal; D014408:Biomarkers, Tumor