Synthesis and SAR of aminopyrimidines as novel c-Jun N-terminal kinase (JNK) inhibitors.
The development of a series of novel aminopyrimidines as inhibitors of c-Jun N-terminal kinases is described. The synthesis, in vitro inhibitory values for JNK1, JNK2 and CDK2, and the in vitro inhibitory value for a c-Jun cellular assay are discussed.
Alam
Mahbub
M
UCB, Granta Park, Great Abington, Cambridge CB21 6GS, UK.
Beevers
Rebekah E
RE
Ceska
Tom
T
Davenport
Richard J
RJ
Dickson
Karen M
KM
Fortunato
Mara
M
Gowers
Lewis
L
Haughan
Alan F
AF
James
Lynwen A
LA
Jones
Mark W
MW
Kinsella
Natasha
N
Lowe
Christopher
C
Meissner
Johannes W G
JW
Nicolas
Anne-Lise
AL
Perry
Benjamin G
BG
Phillips
David J
DJ
Pitt
William R
WR
Platt
Adam
A
Ratcliffe
Andrew J
AJ
Sharpe
Andrew
A
Tait
Laura J
LJ
D051357:Cyclin-Dependent Kinase 2 / Q000037:antagonists & inhibitors; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology*; D048031:JNK Mitogen-Activated Protein Kinases / Q000037:antagonists & inhibitors*; D048055:Mitogen-Activated Protein Kinase 8 / Q000037:antagonists & inhibitors; D048056:Mitogen-Activated Protein Kinase 9 / Q000037:antagonists & inhibitors; D008956:Models, Chemical; D013329:Structure-Activity Relationship
D004791:Enzyme Inhibitors; D048056:Mitogen-Activated Protein Kinase 9; D051357:Cyclin-Dependent Kinase 2; D048031:JNK Mitogen-Activated Protein Kinases; D048055:Mitogen-Activated Protein Kinase 8