title: A case report of simultaneous thrombosis of two coronary artery stents in association with clopidogrel resistance.
abstract: Despite aggressive antiplatelet therapy in the setting of PCI, the incidence of acute stent thrombosis remains approximately 0.5-2%. We report a patient with simultaneous thrombosis of two drug-eluting coronary artery stents, suggesting a systemic thrombotic state. Evaluation by optical platelet aggregometry revealed clopidogrel resistance, which was overcome at a higher drug dose. We aim to highlight the potential utility of platelet function analysis to guide therapy for patients in whom inadequate antiplatelet therapy may have catastrophic clinical outcomes.
authors: University of North Carolina at Chapel Hill, School of Medicine, USA. jin_lee@med.unc.edu
authors: Jin Sun
authors: JS
authors: Lee
authors: Steven P
authors: SP
authors: Dunn
authors: Helen M
authors: HM
authors: Marshall
authors: Mauricio G
authors: MG
authors: Cohen
authors: Susan S
authors: SS
authors: Smyth
mesh_terms: D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D000077144:Clopidogrel; D023921:Coronary Stenosis / Q000628:therapy; D003328:Coronary Thrombosis / Q000209:etiology* / Q000503:physiopathology; D004351:Drug Resistance / Q000187:drug effects; D006801:Humans; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D010979:Platelet Function Tests; D015607:Stents / Q000009:adverse effects*; D013988:Ticlopidine / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D010975:Platelet Aggregation Inhibitors; D000077144:Clopidogrel; D013988:Ticlopidine