Effect of chlorhexidine mouthrinse on cathepsin C activity in human saliva.
Chlorhexidine is an active agent commonly used against dental plaque in the mouth apart from fluorides applied to prevent caries. It is contained in toothpastes and mouthrinses.


OBJECTIVE
The aim of the study was to assess the effect of mouthrinses containing chlorhexidine digluconate on the activity of cathepsin C in human saliva.


METHODS
Material for analyses contained mixed saliva samples collected at rest, directly into test tubes (Z PS type, Medlab) at least 2 hours after meal from 40 subjects (dentistry students; 30 women and 10 men), aged 19-24. Saliva was collected before the preparations were applied after rinsing the mouth with distilled water and following a single use of the preparations according to the producer's instructions, 8 samples for each preparation.


RESULTS
The decrease of cathepsin C was observed for each preparation, but was the greatest after mouth rinsing with Kin Gingival (65.08%) and Corsodyl (58.00%).


CONCLUSIONS
The current study confirms this assumption by finding a decrease in cathepsin C activity after the use of chlorhexidine mouth rinses.
Dabrowska
E
E
Department of Social and Preventive Dentistry, Medical University of Białystok, Poland. helpdentamb@tlen.pl
Letko
M
M
Roszkowska-Jakimiec
W
W
Letko
R
R
Sadowski
J
J
D000328:Adult; D016022:Case-Control Studies; D020789:Cathepsin C / Q000032:analysis / Q000037:antagonists & inhibitors*; D002710:Chlorhexidine / Q000031:analogs & derivatives* / Q000494:pharmacology; D005260:Female; D006801:Humans; D008297:Male; D009067:Mouthwashes / Q000494:pharmacology*; D012463:Saliva / Q000201:enzymology*
D009067:Mouthwashes; D020789:Cathepsin C; C010882:chlorhexidine gluconate; D002710:Chlorhexidine