Eight weeks of aromatase inhibition using the nutritional supplement Novedex XT: effects in young, eugonadal men.
This study examined the effects of an aromatase-inhibiting nutritional supplement on serum steroid hormones, body composition, and clinical safety markers. Sixteen eugonadal young men ingested either Novedex XT or a placebo daily for 8 wk, followed by a 3-wk washout period. Body composition was assessed and blood and urine samples obtained at weeks 0, 4, 8, and 11. Data were analyzed by 2-way repeated-measures ANOVA. Novedex XT resulted in average increases of 283%, 625%, 566%, and 438% for total testosterone (P=0.001), free testosterone (P=0.001), dihydrotestosterone (P=0.001), and the testosterone:estrogen ratio (P=0.001), respectively, whereas fat mass decreased 3.5% (P=0.026) during supplementation. No significant differences were observed in blood and urinary clinical safety markers or for any of the other serum hormones (P>0.05). This study indicates that Novedex XT significantly increases serum androgen levels and decreases fat mass.
Willoughby
Darryn S
DS
Department of Health, Human Performance, and Recreation, Baylor University, Waco, TX 76798-7313, USA.
Wilborn
Colin
C
Taylor
Lemuel
L
Campbell
William
W
D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism; D000328:Adult; D000704:Analysis of Variance; D047072:Aromatase Inhibitors / Q000494:pharmacology*; D001823:Body Composition / Q000187:drug effects* / Q000502:physiology; D018592:Cross-Over Studies; D019587:Dietary Supplements; D004967:Estrogens / Q000097:blood*; D006801:Humans; D008297:Male; D013739:Testosterone / Q000097:blood*; D013997:Time Factors
D047072:Aromatase Inhibitors; D004967:Estrogens; D013739:Testosterone