title: Cell migration rate on poly(epsilon-caprolactone)/poly(ethylene glycol) diblock copolymers and correlation with the material sliding angle.
abstract: The nanostructure of a biomaterial surface has strong influence on cell behavior. The migration of cells on nanostructured surfaces, however, has not been investigated so far. In this study, we used PCL/PEG diblock copolymers as model surfaces to examine the effect of nanoislands on migration of different cells, including fibroblasts and endothelial cells. The water sliding angle of the substrates was measured. The cell migration rate was examined under a real-time optical microscope. It was found that a greater cell migration rate correlated with the smaller sliding angle of the substrate.
authors: Center of Tissue Engineering and Stem Cells Research, National Chung Hsing University, Taichung, Taiwan, Republic of China. shhsu@nchu.edu.tw
authors: Shan-hui
authors: SH
authors: Hsu
authors: Cheng-Ming
authors: CM
authors: Tang
authors: Jeng-Jiann
authors: JJ
authors: Chiu
authors: Tien-Chi
authors: TC
authors: Liao
authors: Chu-Chieh
authors: CC
authors: Lin
authors: Hiroo
authors: H
authors: Iwata
mesh_terms: D000818:Animals; D002339:Carotid Arteries / Q000166:cytology / Q000502:physiology*; D002417:Cattle; D002465:Cell Movement / Q000502:physiology*; D002478:Cells, Cultured; D020099:Coated Materials, Biocompatible / Q000737:chemistry; D042783:Endothelial Cells / Q000166:cytology / Q000502:physiology*; D005026:Ethylene Glycols / Q000737:chemistry; D005347:Fibroblasts / Q000166:cytology / Q000502:physiology*; D006801:Humans; D011091:Polyesters / Q000737:chemistry
chemical_list: D020099:Coated Materials, Biocompatible; D005026:Ethylene Glycols; D011091:Polyesters; C476300:poly(epsilon-caprolactone)-b-poly(ethylene glycol)