Relevance of KIR gene matching in unrelated hematopoietic stem cell transplantations.
The aim of this collaborative study was to evaluate the impact of killer cell immunoglobulin-like receptor (KIR) gene disparities on unrelated hematopoietic stem cell transplantations (HSCT) outcome. To address this question, we have determined the presence or absence of 14 functional KIR genes in HLA-matched (n= 164) or HLA-mismatched (n= 100) donor/recipient pairs and investigated whether KIR gene disparities had an impact on both the occurrence of acute graft-vs-host-disease incidence and overall survival. In a univariate analysis, our preliminary results suggest a detrimental effect of a few KIR gene disparities on patient survival that should be avoided in unrelated HSCT.
Gagne
K
K
HLA laboratory, EFS Nantes, France.
Busson
M
M
Balere-Appert
M L
ML
Absi
L
L
Jollet
I
I
Bignon
J-D
JD
Bois
M
M
Dormoy
A
A
Dubois
V
V
Gebuhrer
L
L
Loiseau
P
P
Masson
D
D
Moine
A
A
Perrier
P
P
Reviron
D
D
Charron
D
D
Raffoux
C
C
D000208:Acute Disease; D006086:Graft vs Host Disease; D020544:Graft vs Leukemia Effect; D006680:HLA Antigens / Q000502:physiology; D019337:Hematologic Neoplasms / Q000150:complications / Q000276:immunology / Q000628:therapy*; D018380:Hematopoietic Stem Cell Transplantation; D006650:Histocompatibility Testing; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology; D009364:Neoplasm Recurrence, Local / Q000235:genetics; D011971:Receptors, Immunologic / Q000235:genetics* / Q000276:immunology; D054340:Receptors, KIR; D015996:Survival Rate; D014019:Tissue Donors
D006680:HLA Antigens; D011971:Receptors, Immunologic; D054340:Receptors, KIR