title: Chondroprotective potential of root extracts of Withania somnifera in osteoarthritis.
abstract: This is the first report describing two novel chondroprotective activities of aqueous extracts of Withania somnifera root powder.First,these extracts had a statistically significant,short-term chondroprotective effect on damaged human osteoarthritic cartilage matrix in 50% of the patients tested. Second,these extracts caused a significant and reproducible inhibition of the gelatinase activity of collagenase type 2 enzyme in vitro.
authors: Interactive Research School for Health Affairs (IRSHA), Bhartiya Vidyapeeth Deemed University Medical College Campus, Dhankawadi, Pune 411043, India. vsumantran@gmail.com
authors: Venil N
authors: VN
authors: Sumantran
authors: Asavari
authors: A
authors: Kulkarni
authors: Sanjay
authors: S
authors: Boddul
authors: Trushna
authors: T
authors: Chinchwade
authors: Soumya J
authors: SJ
authors: Koppikar
authors: Abhay
authors: A
authors: Harsulkar
authors: Bhushan
authors: B
authors: Patwardhan
authors: Arvind
authors: A
authors: Chopra
authors: Ulhas V
authors: UV
authors: Wagh
mesh_terms: D000368:Aged; D064236:Cartilage Oligomeric Matrix Protein; D016326:Extracellular Matrix Proteins / Q000378:metabolism; D006023:Glycoproteins / Q000378:metabolism; D006801:Humans; D064235:Matrilin Proteins; D020784:Matrix Metalloproteinase 8 / Q000378:metabolism; D008875:Middle Aged; D010003:Osteoarthritis / Q000188:drug therapy*; D008517:Phytotherapy / Q000379:methods*; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D018517:Plant Roots / Q000737:chemistry*; D011509:Proteoglycans / Q000378:metabolism; D013053:Spectrophotometry; D013997:Time Factors; D032341:Withania / Q000737:chemistry*
chemical_list: D064236:Cartilage Oligomeric Matrix Protein; D016326:Extracellular Matrix Proteins; D006023:Glycoproteins; D064235:Matrilin Proteins; D010936:Plant Extracts; D011509:Proteoglycans; C577553:TSP5 protein, human; D020784:Matrix Metalloproteinase 8