Factor VII polymorphisms influence the plasma response to diets with different fat content, in a healthy Caucasian population.
To determine the influence of the factor VII gene polymorphisms, R353Q and 5'F7, on factor VII Ag plasma levels after the consumption of diets with different fat contents.


METHODS
59 healthy individuals (42 RR, 16 RQ, 1 QQ at the R353Q and 46 A1A1, 13 A1A2 at the 5'F7) consumed 3 diets during 4-weeks each: a Saturated diet (SAT) enriched in saturated fatty acid (SFA) (38% fat, 20% SFA), followed by a carbohydrate (CHO)-rich diet (30% fat, 55% CHO) or a Mediterranean diet (MEDIT) enriched in monounsaturated fatty acid (MUFA) (38% fat, 22% MUFA) following a randomized crossover design. Plasma lipids and FVII Ag plasma levels were determined at the end of each dietary period.


RESULTS
After a SAT diet, RR homozygotes had greater concentrations of FVII Ag compared with MEDIT and CHO diets than did carriers of the minority Q allele (82.76 +/- 1.3 vs. 75.02 +/- 2.4, p = 0.001). The 5'F7 polymorphism behaved in a similar fashion (A1A1 81.98 +/- 1.4 vs. A1A2 75.37 +/- 2.4, p = 0.026).


CONCLUSIONS
Our data show that carriers of the RR and/or A1A1 genotype present higher FVII Ag levels after the consumption of a SAT diet compared with the MEDIT and CHO rich diets.
Fernández de la Puebla
Rafael Angel
RA
Reina Sofia University Hospital, Lipids and Atherosclerosis Research Unit, University of Cordoba, Ciber Fisiopatologia Obesidad y Nutricion, Instituto Salud Carlos III, Cordoba, Spain.
Pérez-Martínez
Pablo
P
Carmona
José
J
López-Miranda Carmen Marín
José
J
Paniagua
Juan Antonio
JA
Fuentes
Francisco
F
Pérez-Jiménez
Francisco
F
D000328:Adult; D018592:Cross-Over Studies; D038441:Diet, Mediterranean; D004040:Dietary Carbohydrates / Q000008:administration & dosage; D004041:Dietary Fats / Q000008:administration & dosage*; D005167:Factor VII / Q000032:analysis* / Q000235:genetics*; D005227:Fatty Acids / Q000008:administration & dosage; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic
D004040:Dietary Carbohydrates; D004041:Dietary Fats; D005227:Fatty Acids; D005167:Factor VII