Transplant arteriopathy.
Renal allograft rejection is classified based upon its time of onset and vulnerability to therapeutic reversal as hyperacute, acute, and chronic rejection. However, this classification has certain limitations, like the nomenclature of acute rejection despite the fact that it can occur any time after transplantation. Similarly, the onset of lesions characteristic of chronic rejection may appear very early, even as soon as 2 to 4 weeks posttransplant. Apparently the process of acute/chronic rejection does not follow a protracted time course; instead, the process can be ongoing, regardless of chronology. Another way of classifying various types of rejection may be in terms of different mediators that are involved in effecting each of the phenomena. This schema of classification based on pathogenetic mediators of rejection may help in evolving strategies for treatment targeted to specific mechanisms of rejection.
Gupta
R K
RK
Department of Pathology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India. rkgupta@sgpgi.ac.in
D000208:Acute Disease; D000917:Antibody Formation; D002908:Chronic Disease; D006084:Graft Rejection / Q000145:classification / Q000276:immunology*; D006801:Humans; D016030:Kidney Transplantation / Q000276:immunology*; D012077:Renal Artery; D014652:Vascular Diseases / Q000145:classification / Q000175:diagnosis*