Ototoxicity after intraperitoneal chemotherapy: a case report.
Recently, the National Cancer Institute endorsed intraperitoneal (IP) therapy as the treatment of choice for optimally debulked epithelial ovarian cancer. However, there are no drug regimens that are clearly indicated, and the exact method of administration has not been established. Furthermore and most importantly, physicians are unaware of what toxicities should be expected with their use of IP therapy. We report a recent unanticipated toxicity from IP cisplatin therapy and review the literature. A 63-year-old female with optimally debulked stage IIIC papillary serous carcinoma of ovary was admitted on postoperative day 14 for her first cycle of IP cisplatin. She received a cisplatin infusion of 100 mg/m(2). Four days after the cycle, she suffered acute onset of bilateral tinnitus and hearing loss (ototoxicity grade 3). Thus, we conclude that high-frequency hearing loss remains a potentially serious and permanent adverse effect of cisplatin.
Nieves
L
L
Department of Obstetrics and Gynecology, Brody School of Medicine of East Carolina University, Greenville, North Carolina, USA. lucybeth-nieves@hotmail.com
Currie
J
J
Hoffman
J
J
Sorosky
J I
JI
D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D034381:Hearing Loss / Q000139:chemically induced* / Q000175:diagnosis*; D006801:Humans; D007263:Infusions, Parenteral / Q000009:adverse effects; D010051:Ovarian Neoplasms / Q000188:drug therapy*; D010529:Peritoneal Cavity
D002945:Cisplatin