title: Iron dependent degradation of an isothiazolone biocide (5-chloro-2-methyl-4-isothiazolin-3-one).
abstract: An isothiazolone biocide, 5-chloro-2-methyl-4-isothiazolin-3-one (CMI), was degraded in the presence of iron. According to the Fe-dependent degradation of CMI, stoichiometric production of chloride was observed. Copper and stainless steel did not enhance the physico-chemical degradation of CMI, whilst phosphate inhibited the Fe-dependent degradation. Neither aerobic nor anaerobic conditions influenced the Fe-dependent CMI degradation. Furthermore, FeO(OH)-powder and Fe(3)O(4)-powder did not lead to the physico-chemical degradation of CMI. Rapid disappearance of CMI was observed in an operating cooling water plant. CMI added to the cooling tower declined from 1.4 mg l(-1) to < 0.1 mg l(-1) in 2 d. This finding is important in optimising the use of CMI and combating resistance if encountered.
authors: Department of Bioengineering, Tokyo Institute of Technology, Yokohama, Japan. ytanji@bio.titech.ac.jp
authors: Y
authors: Y
authors: Tanji
authors: T
authors: T
authors: Nishihara
authors: K
authors: K
authors: Miyanaga
mesh_terms: D000332:Aerobiosis; D000693:Anaerobiosis; D001673:Biodegradation, Environmental; D018441:Biofilms / Q000187:drug effects / Q000254:growth & development; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004202:Disinfectants / Q000378:metabolism / Q000494:pharmacology; D007501:Iron; D013844:Thiazoles / Q000378:metabolism / Q000494:pharmacology; D014871:Water Microbiology
chemical_list: D004202:Disinfectants; D013844:Thiazoles; C011421:5-chloro-2-methyl-4-isothiazolin-3-one; D007501:Iron