Firocoxib efficacy preventing urate-induced synovitis, pain, and inflammation in dogs.
This positive-control study evaluated the efficacy of firocoxib versus carprofen, deracoxib, and meloxicam for the prevention of pain and inflammation in a urate crystal synovitis model of lameness. Lameness scoring and force plate gait analysis were used to assess efficacy. The resulting lameness scores and force plate ground reaction forces after urate crystal injection were not significantly different among the groups. Relative to each group's baseline (nonlame) score, only the firocoxib group was not significantly lame, based on lameness score, at the model's peak effect.
Drag
Marlene
M
Merial Limited, 3239 Satellite Boulevard, Duluth, GA 30096, USA.
Kunkle
Bruce N
BN
Romano
Davida
D
Hanson
Peter D
PD
D015107:4-Butyrolactone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000818:Animals; D002227:Carbazoles / Q000008:administration & dosage / Q000627:therapeutic use; D052246:Cyclooxygenase 2 Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use*; D004283:Dog Diseases / Q000188:drug therapy* / Q000473:pathology; D004285:Dogs; D005260:Female; D007794:Lameness, Animal / Q000139:chemically induced / Q000188:drug therapy; D008297:Male; D000077239:Meloxicam; D012720:Severity of Illness Index; D013449:Sulfonamides / Q000008:administration & dosage / Q000627:therapeutic use; D013450:Sulfones / Q000008:administration & dosage / Q000627:therapeutic use*; D013585:Synovitis / Q000139:chemically induced / Q000188:drug therapy / Q000662:veterinary*; D013843:Thiazines / Q000008:administration & dosage / Q000627:therapeutic use; D013844:Thiazoles / Q000008:administration & dosage / Q000627:therapeutic use; D016896:Treatment Outcome; D014527:Uric Acid; D000096926:Benzenesulfonamides
D015107:4-Butyrolactone; D002227:Carbazoles; D052246:Cyclooxygenase 2 Inhibitors; D000077239:Meloxicam; D013449:Sulfonamides; D013450:Sulfones; D013843:Thiazines; D013844:Thiazoles; D014527:Uric Acid; C007005:carprofen; C471996:deracoxib; D000096926:Benzenesulfonamides; C487384:firocoxib