Whither withered Golgi? A retrospective evaluation of reticularist and synaptic constructs.
The 100th anniversary of the shared first Nobel prize in neuroscience by Camillo Golgi and Ramon y Cajal invites reappraisal of the merits of the arguments adduced by these two combative scientists in the light of contemporary knowledge. Guided by cogent reasons for reluctance in accepting the inviolable polarity principle of the neuron doctrine and concern for explaining cerebral recovery of function, Golgi joined the 'reticularists' of his generation. Modern observations of axo-axonic and dendro-dendritic synapses, gap-junction interconnections, rules for the direction and mode of analog or impulse conduction, the myriad diversity of ion channels and gating principles and the complexities of synaptic plasticity have eclipsed the polarized neuron doctrine explanations of reflex physiology and the 'fixed and immutable' connections successfully championed by Cajal. Without violating the cell theory, expanded modes of neuronal and glial communication have encompassed reticularist notions and provided insight into the long-term changes underlying synaptic and extra-synaptic neural patterns. Both laureates espoused operative principles that have survived in different modes and distinctive temporal domains. Together, they reflect the roots of our contemporary understanding of neural interaction.
Kruger
Lawrence
L
Department of Neurobiology, UCLA David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA. lkruger@ucla.edu
Otis
Thomas S
TS
D000818:Animals; D002531:Cerebellum / Q000166:cytology; D017629:Gap Junctions / Q000648:ultrastructure; D049672:History, 19th Century; D049673:History, 20th Century; D006801:Humans; D008854:Microscopy, Electron / Q000379:methods; D009445:Neuroanatomy / Q000266:history / Q000379:methods; D009474:Neurons / Q000166:cytology*; D016622:Silver Staining / Q000266:history / Q000379:methods*; D013569:Synapses / Q000648:ultrastructure*