An application of the patient rule-induction method for evaluating the contribution of the Apolipoprotein E and Lipoprotein Lipase genes to predicting ischemic heart disease.
Different combinations of genetic and environmental risk factors are known to contribute to the complex etiology of ischemic heart disease (IHD) in different subsets of individuals. We employed the Patient Rule-Induction Method (PRIM) to select the combination of risk factors and risk factor values that identified each of 16 mutually exclusive partitions of individuals having significantly different levels of risk of IHD. PRIM balances two competing objectives: (1) finding partitions where the risk of IHD is high and (2) maximizing the number of IHD cases explained by the partitions. A sequential PRIM analysis was applied to data on the incidence of IHD collected over 8 years for a sample of 5,455 unrelated individuals from the Copenhagen City Heart Study (CCHS) to assess the added value of variation in two candidate susceptibility genes beyond the traditional, lipid and body mass index risk factors for IHD. An independent sample of 362 unrelated individuals also from the city of Copenhagen was used to test the model obtained for each of the hypothesized partitions.
Dyson
Greg
G
Department of Human Genetics, University of Michigan, Ann Arbor, Michigan 48109-0618, USA, and Department of Clinical Biochemistry, Section for Molecular Genetics, Rigshospitalet, Copenhagen University Hospital, Denmark.
Frikke-Schmidt
Ruth
R
Nordestgaard
Børge G
BG
Tybjaerg-Hansen
Anne
A
Sing
Charles F
CF
D000368:Aged; D000465:Algorithms; D001057:Apolipoproteins E / Q000235:genetics*; D002784:Cholesterol / Q000378:metabolism; D005260:Female; D005823:Genetics; D005838:Genotype; D006331:Heart Diseases / Q000235:genetics*; D006801:Humans; D008071:Lipoprotein Lipase / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D008957:Models, Genetic; D017202:Myocardial Ischemia / Q000235:genetics* / Q000473:pathology*; D012307:Risk Factors
D001057:Apolipoproteins E; D002784:Cholesterol; D008071:Lipoprotein Lipase