Evaluation of 13C-urea breath test and fecal antigen immunoassay to detect Helicobacter pylori infection in Gambian infants.
Helicobacter pylori colonization was measured by [13C]-urea breath test in 198 Gambian infants and by fecal enzyme-linked immunosorbent assay in 52 of the 198 at ages 2, 5, and 12 months. By 12 months there was good concordance between tests; 33 of 44 (75%) test results were positive by enzyme-linked immunosorbent assay, and 29 of 44 (66%) test results were positive by urea breath test. H. pylori colonization is common among Gambian infants, and noninvasive tests can provide a reliable means of diagnosis.
Jones
Rhys T
RT
University of Newcastle, School of Clinical Medical Sciences, Newcastle-upon-Tyne, UK.
Darboe
Momodou K
MK
Doherty
Conor P
CP
MacKay
William G
WG
Weaver
Lawrence T
LT
Campbell
David I
DI
Thomas
Julian E
JE
D000942:Antigens, Bacterial / Q000302:isolation & purification; D001944:Breath Tests / Q000379:methods*; D004797:Enzyme-Linked Immunosorbent Assay; D005243:Feces / Q000382:microbiology*; D005714:Gambia; D016481:Helicobacter Infections / Q000175:diagnosis*; D016480:Helicobacter pylori / Q000302:isolation & purification*; D006801:Humans; D007223:Infant; D011446:Prospective Studies
D000942:Antigens, Bacterial