Gamma-delta T-cell-mediated dilated cardiomyopathy.
Gamma-delta T-cells are usually minor component of peripheral blood and lymphoid tissues, but may play an important role in autoimmune diseases. We here describe the first case of dilated cardiomyopathy (DCM) with heart infiltration by mostly gamma-delta T-cells, who improved significantly by steroid therapy. In general, steroid therapy has only a little effect on DCM, however these findings might have implications with respect to the selection of patients who might respond to immunosuppressive therapy.
Takeda
Norifumi
N
Seko
Yoshinori
Y
Oriuchi
Noboru
N
Nagai
Ryozo
R
D000328:Adult; D015551:Autoimmunity; D002311:Cardiomyopathy, Dilated / Q000188:drug therapy / Q000276:immunology* / Q000503:physiopathology; D006801:Humans; D007150:Immunohistochemistry; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008213:Lymphocyte Activation; D008221:Lymphoid Tissue; D008297:Male; D009205:Myocarditis / Q000276:immunology; D049268:Positron-Emission Tomography; D011239:Prednisolone / Q000627:therapeutic use; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000187:drug effects*; D013318:Stroke Volume; D013601:T-Lymphocytes
D007166:Immunosuppressive Agents; D016692:Receptors, Antigen, T-Cell, gamma-delta; D011239:Prednisolone