A manual-based intervention to address clinical crises and retain patients in the Treatment of Adolescents With Depression Study (TADS).
OBJECTIVE
To describe a manual-based intervention to address clinical crises and retain participants in the Treatment for Adolescents With Depression Study (TADS).


METHODS
The use of adjunct services for attrition prevention (ASAP) is described for adolescents (ages 12-17 years) during the 12-week acute treatment in TADS, from 2000 to 2003. Logistic regression, controlling for site, was used to predict use.


RESULTS
Of 439 enrolled participants, 17.8% (n = 78) used ASAP primarily for suicidality or worsening of depression. Of these, 46.2% continued in their assigned treatment through week 12, 47.4% received out-of-protocol treatment but continued participating in assessments, and 10.3% withdrew consent, including 3 who terminated treatment and withdrew consent on the same date. ASAP use did not differ between treatments (p =.97) and typically occurred early in treatment. At the end of the 12 weeks, 37.2% of participants using ASAP remained in their assigned treatment, although 80.8% continued participating in assessments. ASAP was associated with, at baseline, a higher severity of depression (p <.01), substance use (p <.01), and precontemplation level of change (p <.02).


CONCLUSIONS
ASAP may be useful to retain adolescent participants and as a safety intervention in placebo-controlled trials. In clinical practice ASAP-like procedures may be useful to encourage adherence in patients engaging in long-term treatment. Clinical trial registration information-URL: http://www.clinicaltrials.gov. Unique identifier: NCT00006286.
May
Diane E
DE
Ms. Puumala, Ms. Rezac and Ms. Hallin are with the University of Nebraska Medical Center, Omaha. Electronic address: dmay@unmc.edu.
Kratochvil
Christopher J
CJ
Ms. Puumala, Ms. Rezac and Ms. Hallin are with the University of Nebraska Medical Center, Omaha.
Puumala
Susan E
SE
Ms. Puumala, Ms. Rezac and Ms. Hallin are with the University of Nebraska Medical Center, Omaha.
Silva
Susan G
SG
Ms. Puumala, Ms. Rezac and Ms. Hallin are with the University of Nebraska Medical Center, Omaha.
Rezac
Amy J
AJ
Ms. Puumala, Ms. Rezac and Ms. Hallin are with the University of Nebraska Medical Center, Omaha.
Hallin
Mary J
MJ
Ms. Puumala, Ms. Rezac and Ms. Hallin are with the University of Nebraska Medical Center, Omaha.
Reinecke
Mark A
MA
Ms. Puumala, Ms. Rezac and Ms. Hallin are with the University of Nebraska Medical Center, Omaha.
Vitiello
Benedetto
B
Ms. Puumala, Ms. Rezac and Ms. Hallin are with the University of Nebraska Medical Center, Omaha.
Weller
Elizabeth B
EB
Ms. Puumala, Ms. Rezac and Ms. Hallin are with the University of Nebraska Medical Center, Omaha.
Pathak
Sanjeev
S
Ms. Puumala, Ms. Rezac and Ms. Hallin are with the University of Nebraska Medical Center, Omaha.
Simons
Anne D
AD
Ms. Puumala, Ms. Rezac and Ms. Hallin are with the University of Nebraska Medical Center, Omaha.
March
John S
JS
Ms. Puumala, Ms. Rezac and Ms. Hallin are with the University of Nebraska Medical Center, Omaha.
D000293:Adolescent; D002648:Child; D003419:Crisis Intervention / Q000379:methods*; D003617:Dangerous Behavior; D003865:Major Depressive Disorder / Q000523:psychology* / Q000628:therapy*; D004637:Emergency Services, Psychiatric; D005260:Female; D006293:Health Promotion; D006801:Humans; D008297:Male; D008370:Manuals as Topic; D010349:Patient Compliance; D011795:Surveys and Questionnaires