title: Structures of new cytotoxic antibiotics, piericidins C7 and C8.
abstract: Two new cytotoxic antibiotics, piericidins C7 (1) and C8 (2), were isolated from a marine Streptomyces sp. High-resolution FAB-MS established the molecular formulae of 1 and 2 as C28H41NO5 and C29H43NO5, respectively. The planar structures of the piericidins were elucidated by NMR spectral analysis including COSY, HMQC and HMBC. The relative stereochemistry of 2 was determined based on NOESY and coupling constant analyses. 1 and 2 are new members of the piericidin family possessing 11,12-epoxide and 12-butenyl groups.
authors: Faculty of Pharmaceutical Sciences, Tokyo University of Science, Noda, Chiba, Japan. hykw@rs.noda.tus.ac.jp
authors: Yoichi
authors: Y
authors: Hayakawa
authors: Shingo
authors: S
authors: Shirasaki
authors: Takashi
authors: T
authors: Kawasaki
authors: Yoshihide
authors: Y
authors: Matsuo
authors: Kyoko
authors: K
authors: Adachi
authors: Yoshikazu
authors: Y
authors: Shizuri
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000737:chemistry*; D004852:Epoxy Compounds / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D011725:Pyridines / Q000737:chemistry*; D013237:Stereoisomerism; D013302:Streptomyces / Q000378:metabolism*
chemical_list: D000903:Antibiotics, Antineoplastic; D004852:Epoxy Compounds; D011725:Pyridines