title: The GBV-C envelope glycoprotein E2 does not interact specifically with CD81.
abstract: The addition of GB virus C (GBV-C) E2 protein to cells inhibits HIV replication in vitro, presumably triggered by interactions with a specific cellular receptor. Indirect evidence suggests that CD81 is the GBV-C E2 cellular receptor. We found that E2 binding to cells was not dependent upon human CD81, and that soluble CD81 did not compete with GBV-C E2 for cell binding. GBV-C E2 protein thus does not appear to interact with CD81.
authors: Iowa City VA Medical Center and the University of Iowa, Iowa City, Iowa, USA.
authors: Thomas M
authors: TM
authors: Kaufman
authors: James H
authors: JH
authors: McLinden
authors: Jinhua
authors: J
authors: Xiang
authors: Alfred M
authors: AM
authors: Engel
authors: Jack T
authors: JT
authors: Stapleton
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000378:metabolism*; D000956:Antigens, Viral / Q000378:metabolism; D001667:Binding, Competitive; D015496:CD4-Positive T-Lymphocytes / Q000378:metabolism*; D016466:CHO Cells; D006224:Cricetinae; D003412:Cricetulus; D029407:GB virus C / Q000276:immunology; D006801:Humans; D008562:Membrane Glycoproteins / Q000378:metabolism; D051379:Mice; D060225:Tetraspanin 28; D014759:Viral Envelope Proteins / Q000378:metabolism*
chemical_list: D015703:Antigens, CD; D000956:Antigens, Viral; C554798:CD81 protein, human; C554799:Cd81 protein, mouse; D008562:Membrane Glycoproteins; D060225:Tetraspanin 28; D014759:Viral Envelope Proteins; C107619:glycoprotein E2, GB virus C