Computational analysis of Ancylostoma ceylanicum cysteine proteinase.
The potential tertiary structure of Ancylostoma ceylanicum cysteine proteinase was obtained by Automatic Program 3D-JIGSAW and used for finding homologues of known structure by VAST program. The results of computational analysis showed the presence of domains recognizing host immunoglobulins. Based on this analysis we suggest that this protein is involved in cleaving of host antibodies and therefore it may be promising vaccine candidate. In this paper we present the computational analysis of parasitic antigen which is very helpful in evaluation of the potential role of this protein.
Baska
Piotr
P
Division of Parasitology, Faculty of Veterinary Medicine, Warsaw Agricultural University, Ciszewskiego 8, 02-786 Warszawa, Poland.
Wísniewski
Marcin
M
Mieszczanek
Juliusz
J
Wedrychowicz
Halina
H
D000595:Amino Acid Sequence; D000722:Ancylostoma / Q000201:enzymology* / Q000235:genetics / Q000276:immunology; D000724:Ancylostomiasis / Q000276:immunology; D000818:Animals; D000909:Antibodies, Helminth / Q000276:immunology / Q000302:isolation & purification; D000947:Antigens, Helminth / Q000737:chemistry* / Q000235:genetics / Q000276:immunology* / Q000302:isolation & purification; D003546:Cysteine Endopeptidases / Q000737:chemistry* / Q000235:genetics / Q000302:isolation & purification; D016208:Databases, Factual; D015801:Helminth Proteins / Q000737:chemistry* / Q000235:genetics / Q000276:immunology* / Q000302:isolation & purification; D006790:Host-Parasite Interactions / Q000276:immunology; D016415:Sequence Alignment; D012984:Software
D000909:Antibodies, Helminth; D000947:Antigens, Helminth; D015801:Helminth Proteins; D003546:Cysteine Endopeptidases