title: Systemic sclerosis after interferon alphacon-1 therapy for hepatitis C.
abstract: A 66-year-old woman developed systemic sclerosis (SSc) after receiving interferon alphacon-1 (IFNalphacon-1; consensus interferon) therapy for chronic hepatitis C. She suffered from Raynauds phenomenon about 1 year after a course of IFNalphacon-1 therapy. The combination of proximal scleroderma, Raynauds phenomenon, and ANA positivity led to a diagnosis of systemic sclerosis (SSc). IFN has multiple effects on the immune system and is known to trigger the development of autoantibodies, as well as the onset or exacerbation of autoimmune disease. We suspect that the immunomodulatory effects of IFNalphacon-1 triggered the clinical manifestations of SSc in this patient. To our knowledge this is only the third case of SSc after IFNalpha therapy, and it is the first case associated with IFNalphacon-1 therapy.
authors: Department of Internal Medicine, Kiryu Kosei General Hospital, Kiryu. hirokit@sannet.ne.jp
authors: Hiroki
authors: H
authors: Tahara
authors: Akira
authors: A
authors: Kojima
authors: Tomoyuki
authors: T
authors: Hirokawa
authors: Tatsuya
authors: T
authors: Oyama
authors: Atsushi
authors: A
authors: Naganuma
authors: Sakae
authors: S
authors: Maruta
authors: Katsuyuki
authors: K
authors: Okada
authors: Satoshi
authors: S
authors: Ban
authors: Katsue
authors: K
authors: Yoshida
authors: Hitoshi
authors: H
authors: Takagi
authors: Masatomo
authors: M
authors: Mori
mesh_terms: D000368:Aged; D005260:Female; D019698:Hepatitis C, Chronic / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D007370:Interferon Type I / Q000009:adverse effects*; D016898:Interferon-alpha; D011994:Recombinant Proteins; D012595:Scleroderma, Systemic / Q000139:chemically induced* / Q000175:diagnosis*
chemical_list: D007370:Interferon Type I; D016898:Interferon-alpha; D011994:Recombinant Proteins; C050739:interferon alfacon-1