title: Effect of preoperative administration of tepoxalin on induction dose of injectable anesthetics in dogs.
abstract: Medications given preoperatively have the potential to affect the induction dose of injectable anesthetics, which could result in an anesthetic overdose. Tepoxalin is an NSAID approved for the treatment of arthritis in dogs in the United States and hence could be administered in patients requiring anesthesia. In this study, administration of a single dose or a 10-day course of tepoxalin did not affect the induction dose (dose that allowed intubation) of propofol, thiopental, or ketamine-diazepam and also did not affect the time required for dogs to recover from anesthesia.
authors: Texas A & M University, Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, College Station, TX 77843-4474, USA.
authors: Nora S
authors: NS
authors: Matthews
authors: Katie M
authors: KM
authors: Belz
authors: Geoffrey T
authors: GT
authors: Fosgate
authors: Christopher
authors: C
authors: Pappas
mesh_terms: D000768:Anesthesia, General / Q000662:veterinary*; D018686:Anesthetics, Intravenous / Q000008:administration & dosage; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D003975:Diazepam / Q000008:administration & dosage; D004285:Dogs / Q000502:physiology*; D004347:Drug Interactions; D005260:Female; D007275:Injections, Intravenous / Q000662:veterinary; D007649:Ketamine / Q000008:administration & dosage; D008297:Male; D011229:Preanesthetic Medication / Q000662:veterinary; D015742:Propofol / Q000008:administration & dosage; D011720:Pyrazoles / Q000008:administration & dosage*; D013874:Thiopental / Q000008:administration & dosage; D016896:Treatment Outcome
chemical_list: D018686:Anesthetics, Intravenous; D000894:Anti-Inflammatory Agents, Non-Steroidal; D011720:Pyrazoles; D007649:Ketamine; D013874:Thiopental; D003975:Diazepam; C073135:tepoxalin; D015742:Propofol