title: Effectiveness of hip or knee replacement surgery in terms of quality-adjusted life years and costs.
abstract: BACKGROUND
  Concurrent head-to-head comparisons of healthcare interventions regarding cost-utility are rare. The concept of favorable cost-effectiveness of total hip or knee arthroplasty is thus inadequately verified.
  
  
  METHODS
  In a trial involving several thousand patients from 10 medical specialties, 223 patients who were enrolled for hip or knee replacement surgery were asked to fill in the 15D health-related quality of life (HRQoL) survey before and after operation.
  
  
  RESULTS
  Mean (SD) HRQoL score (on a 0-1 scale) increased in primary hip replacement patients (n = 96) from 0.81 (0.084) preoperatively to 0.86 (0.12) at 12 months (p < 0.001). In revision hip replacement (n = 24) the corresponding scores were 0.81 (0.086) and 0.82 (0.097) respectively (p = 0.4), and in knee replacement (n = 103) the scores were 0.81 (0.093) and 0.84 (0.11) respectively (p < 0.001). Of 15 health dimensions, there were statistically significant improvements in moving, usual activities, discomfort and symptoms, distress, and vitality in both primary replacement groups. Mean cost per quality-adjusted life year (QALY) gained during a 1-year period was euro 6,710 for primary hip replacement, euro 52,274 for revision hip replacement, and euro 13,995 for primary knee replacement.
  
  
  CONCLUSIONS
  Hip and knee replacement both improve HRQoL. The cost per QALY gained from knee replacement is twice that gained from hip replacement.
authors: Helsinki and Uusimaa Hospital Group, Group Administration, P.O. Box 100, HUS 00029, Finland. pirjo.rasanen@hus.fi
authors: Pirjo
authors: P
authors: Räsänen
authors: Pekka
authors: P
authors: Paavolainen
authors: Harri
authors: H
authors: Sintonen
authors: Anna-Maija
authors: AM
authors: Koivisto
authors: Marja
authors: M
authors: Blom
authors: Olli-Pekka
authors: OP
authors: Ryynänen
authors: Risto P
authors: RP
authors: Roine
mesh_terms: D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects / Q000191:economics / Q000523:psychology; D019645:Arthroplasty, Replacement, Knee / Q000009:adverse effects / Q000191:economics / Q000523:psychology; D003362:Cost-Benefit Analysis; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D015207:Osteoarthritis, Hip / Q000523:psychology / Q000601:surgery; D020370:Osteoarthritis, Knee / Q000523:psychology / Q000601:surgery; D011788:Quality of Life; D019057:Quality-Adjusted Life Years; D012086:Reoperation; D011795:Surveys and Questionnaires