[Comparative study on transdermal osmosis in vitro of Aconitum brachypodium liniment, gel and patcher].
OBJECTIVE
To study the transdermal osmosis process of Aconitum brachypodum's liniment, gel and patcher to provide basis for selecting dosage form and controlling the quality.


METHODS
Taking the cumulate rate of transdermal as index, a imitated Fick's diffusion device was used for the investigating the transdermal osmosis course of the three preparations. The best transdermal mathematics models are obtained and the relations between the transdermal course and the release course are analysed.


RESULTS
The three preparations have different characteristics of transdermal osmosis course. The liniment meets dynamics 0 order process, the gel and the patcher meet dynamic 0 order process of non-corroded drug system. And the relation is good cubic equation between their transdermal course and release course.


CONCLUSIONS
The transdermal osmosis experiment in vitro for three preparations can provide basis for selecting dosage form and the quality control in future studies.
Lin
Ya-ping
YP
Guizhou Province Drug Administration, Guiyang 550004, China lypgz@126.com
Zhao
Ying
Y
Zhang
Yong-ping
YP
Liang
Guang-yi
GY
D031841:Aconitum / Q000737:chemistry*; D000279:Administration, Cutaneous; D000818:Animals; D004058:Diffusion; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000302:isolation & purification / Q000493:pharmacokinetics*; D066298:In Vitro Techniques; D008297:Male; D009995:Osmosis; D035281:Plant Tubers / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D011817:Rabbits; D012867:Skin / Q000378:metabolism*; D012869:Skin Absorption
D004365:Drugs, Chinese Herbal