[Autoregulation of cerebral circulation: adaptation to hypertension and re-adaptation in response to antihypertensive treatment].
In chronic hypertension, autoregulation of cerebral blood flow (CBF) is adapted to high blood pressure. Thus in untreated hypertensive patients, the autoregulation curve is shifted towards higher pressure. With antihypertensive treatment autoregulation curve may be shifted back to the normal position or shift upward to the beneficially higher level of CBF. The effect of various antihypertensive drugs on CBF has been discussed.
Pieniazek
Witold
W
Katedra Chorób Wewnetrznych i Gerontologii, Collegium Medicum, Uniwersytetu Jagielońskiego w Krakowie.
Dimitrow
Paweł Petkow
PP
D000222:Adaptation, Physiological / Q000187:drug effects / Q000502:physiology; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects / Q000627:therapeutic use*; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001783:Blood Flow Velocity / Q000187:drug effects* / Q000502:physiology; D002560:Cerebrovascular Circulation / Q000187:drug effects* / Q000502:physiology; D002908:Chronic Disease; D006706:Homeostasis / Q000187:drug effects / Q000502:physiology; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology*; D014665:Vasodilator Agents / Q000009:adverse effects / Q000627:therapeutic use*
D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D014665:Vasodilator Agents