title: [The effect of the homogenates from different developmental stages of the nematode Protostrongylus rufescens (Leuckart, 1895) on mitochondrial and lipid bilayer membranes].
abstract: The effect of the homogenates from different developmental stages of the nematode Protostrongylus rufescens on mitochondrial and lipid bilayer membranes has been studied. The homogenate of P. rufescens affects efficiently the cell energy by the inhibition of the mitochondrial respiration in the metabolic state V3, uncouples oxidative phosphorylation and affects the functions of mitochondria at the level of cyclosporine A-sensitive pore by making it highly permeable. Moreover, the nematode homogenate at the concentration of 1 mkg/ml increases efficiently the integral permeability of lipid bilayer membranes. An increase in this permeability is connected apparently with the formation of single ion channels. The channels of lipid bilayer membranes induced by the nematode homogenate show cation selectivity.
authors: A E
authors: AE
authors: Kuchboev
authors: I
authors: I
authors: Kazakov
authors: M I
authors: MI
authors: Asrarov
authors: D T
authors: DT
authors: Isakova
authors: D A
authors: DA
authors: Azimov
authors: V I
authors: VI
authors: Golovanov
mesh_terms: D000818:Animals; D002412:Cations / Q000378:metabolism; D008051:Lipid Bilayers / Q000378:metabolism*; D008930:Mitochondria, Liver / Q000378:metabolism*; D051336:Mitochondrial Membranes / Q000378:metabolism*; D009348:Nematoda / Q000502:physiology*; D010085:Oxidative Phosphorylation; D010539:Permeability; D051381:Rats; D012756:Sheep; D014020:Tissue Extracts / Q000494:pharmacology*; D050994:Voltage-Dependent Anion Channels / Q000378:metabolism
chemical_list: D002412:Cations; D008051:Lipid Bilayers; D014020:Tissue Extracts; D050994:Voltage-Dependent Anion Channels