title: Sultam thiourea inhibition of West Nile virus.
abstract: We have identified sultam thioureas as novel inhibitors of West Nile virus (WNV) replication. One such compound inhibited WNV, with a 50% effective concentration of 0.7 microM, and reduced reporter expression from cells that harbored a WNV-based replicon. Our results demonstrate that sultam thioureas can block a postentry, preassembly step of WNV replication.
authors: Vollum Institute and Department of Molecular Microbiology and Immunology, Oregon Health & Sciences University, Mail Code L220, 3181 SW Sam Jackson Park Road, Portland, OR 97201-3098, USA. barklis@ohsu.edu
authors: Eric
authors: E
authors: Barklis
authors: Amelia
authors: A
authors: Still
authors: Mohammad I
authors: MI
authors: Sabri
authors: Alec J
authors: AJ
authors: Hirsch
authors: Janko
authors: J
authors: Nikolich-Zugich
authors: James
authors: J
authors: Brien
authors: Tenzin Choesang
authors: TC
authors: Dhenub
authors: Isabel
authors: I
authors: Scholz
authors: Ayna
authors: A
authors: Alfadhli
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D002522:Chlorocebus aethiops; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D012367:RNA, Viral / Q000187:drug effects; D012093:Replicon / Q000187:drug effects / Q000235:genetics; D013329:Structure-Activity Relationship; D013890:Thiourea / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*; D014709:Vero Cells; D014779:Virus Replication / Q000187:drug effects; D014902:West Nile virus / Q000187:drug effects* / Q000502:physiology
chemical_list: D000998:Antiviral Agents; D012367:RNA, Viral; D013890:Thiourea