Outcomes of HIV-infected children with tuberculosis who are started on antiretroviral therapy in Malawi.
METHODS
Mzuzu Central Hospital, in the northern region of Malawi, which provides free antiretroviral therapy (ART) to human immunodeficiency virus (HIV) infected adults and children, including those with tuberculosis (TB).


OBJECTIVE
To compare outcomes in HIV-infected children who have been started on ART because of 1) active TB, 2) a past history of TB in the last 2 years and 3) a non-TB diagnosis.


METHODS
Retrospective data collection using ART patient master cards and ART patient registers.


RESULTS
Between July 2004 and September 2006, 439 (11%) children of a total 3908 patients were started on ART. There were 29 with active TB, 56 with a past history of TB in the last 2 years and 354 with a non-TB diagnosis. The three groups were similar in nutritional indices and CD4-lymphocyte percentages. The 6-month probability of survival was 0.86 in the active TB group, 0.94 in the past history of TB group and 0.89 in the non-TB group. 12-month survival probability for the same groups was 0.86, 0.86 and 0.88, respectively.


CONCLUSIONS
HIV-infected children with active and previous TB who are started on ART have good outcomes that are similar to those of children started on ART due to a non-TB diagnosis.
Bong
C-N
CN
Taiwan Medical Mission, Mzuzu Central Hospital, Mzuzu, Malawi.
Chen
S C C
SC
Jong
Y-J
YJ
Tok
T-S
TS
Hsu
C-F
CF
Schouten
E J
EJ
Makombe
S D
SD
Yu
J K-L
JK
Harries
A D
AD
D000293:Adolescent; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D000995:Antitubercular Agents / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy* / Q000401:mortality; D006801:Humans; D007223:Infant; D008295:Malawi; D008297:Male; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome; D014376:Tuberculosis / Q000150:complications* / Q000188:drug therapy
D019380:Anti-HIV Agents; D000995:Antitubercular Agents