title: The isokinetic assessment of peripheral muscle function in patients with coronary artery disease: correlations with cardiorespiratory capacity.
abstract: OBJECTIVE
  We aimed to determine whether diminished cardiorespiratory capacity in patients with coronary artery disease (CAD) is accompanied by impaired skeletal muscle function as measured by isokinetic dynamometry. We also evaluated the correlation between isokinetic strength and aerobic capacity in these patients.
  
  
  METHODS
  Fifteen CAD patients and 15 age-matched healthy subjects (mean age 60+/-6 vs. 57+/-3.5 years) underwent maximal laboratory exercise testing, a 6-min walking test and an assessment of peripheral skeletal muscle function by use of an isokinetic apparatus. Quadricep and hamstring function was tested at two angular velocities, 150 and 180 degrees s(-1) with simultaneous electrocardiography monitoring. The cardiorespiratory and mechanical parameters (VO(2), ventilatory threshold [VT], heart rate [HR], and power) were measured at VT and at maximal effort.
  
  
  RESULTS
  Quadricep and hamstring peak torque was impaired in CAD patients, with quadriceps peak torque at 180 degrees being 71.13 +/- 14 vs. 91.13 +/- 23 Nm (P<0.01) and hamstring peak torque 46.50+/-10 vs. 59.86+/-12 Nm (P<0.01). CAD subjects presented a deficient aerobic capacity as compared with the healthy subjects at maximal effort. At VT, the VO(2), ventilation, and HR were significantly lower in CAD patients, at 13.77+/-2.33 vs. 17.08+/-3.59 ml min(-1) kg(-1) (P<0.05), 29.64 +/- 664 vs. 37.76 +/- 7.2 ml min(-1) (P<0.05), and 86+/-14 vs. 111+/-15 beats min(-1) (P=0.001), respectively. The 6-min walking distance was significantly shorter for CAD patients than healthy subjects (425.93+/-52.77 vs. 551.46 +/- 57.94 m; P<0.01). In CAD patients quadriceps and hamstring strength was not correlated with VO(2) at maximal effort and at VT. Total distance walked during the 6-min walk and VO(2)max were correlated (r=0.869; P<0.001) but not at VT.
  
  
  CONCLUSIONS
  CAD patients showed impaired cardiorespiratory capacity accompanied by increased muscle fatigability as compared with healthy subjects. An isokinetic muscle assessment in these patients must be achieved systematically and seems to have value in cardiovascular rehabilitation.
authors: Service de médecine physique et de rééducation fonctionnelle, CHU Habib-Bourguiba, Sfax, Tunisie. habib.eleuch@rns.tn
authors: S
authors: S
authors: Ghroubi
authors: M
authors: M
authors: Chaari
authors: H
authors: H
authors: Elleuch
authors: K
authors: K
authors: Massmoudi
authors: M
authors: M
authors: Abdenadher
authors: I
authors: I
authors: Trabelssi
authors: M
authors: M
authors: Akrout
authors: H
authors: H
authors: Feki
authors: I
authors: I
authors: Frikha
authors: J
authors: J
authors: Dammak
authors: S
authors: S
authors: Kammoun
authors: N
authors: N
authors: Zouari
authors: M H
authors: MH
authors: Elleuch
mesh_terms: D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000503:physiopathology*; D005080:Exercise Test; D006801:Humans; D008297:Male; D008875:Middle Aged; D009119:Muscle Contraction / Q000502:physiology; D053580:Muscle Strength / Q000502:physiology*; D053581:Muscle Strength Dynamometer; D018482:Muscle, Skeletal / Q000502:physiology; D012129:Respiratory Function Tests