title: Reactivation of immobilized acetylcholinesterase-tabun complex by methoxime and its homologues.
abstract: Using an immobilized acetylcholinesterase-tabun enzyme-inhibitor complex, the reactivation efficacy of a homologous series of bispyridinium reactivators with increasing length of the alkylene chain between the pyridinium rings has been studied. The number of the alkylene groups in the chain ranged from one to six. N,N'-Monomethylenebis(4-pyridiniumaldoxime) dibromide (MMB-4) and N,N'-trimethylenebis(4-pyridiniumaldoxime) dibromide (TMB-4) are the most efficient reactivators of the series.
authors: University of Defence, Brno, Institute of NBC Defence, Vyskov, Czech Republic. monika.hoskovcova@unob.cz
authors: Monika
authors: M
authors: Hoskovcová
authors: Emil
authors: E
authors: Halámek
authors: Zbynek
authors: Z
authors: Kobliha
authors: Ivana
authors: I
authors: Tusarová
mesh_terms: D000110:Acetylcholinesterase / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D002619:Chemical Warfare Agents / Q000633:toxicity; D002800:Cholinesterase Inhibitors / Q000633:toxicity; D002801:Cholinesterase Reactivators / Q000494:pharmacology*; D004800:Enzymes, Immobilized; D010755:Organophosphates / Q000633:toxicity; D010091:Oximes / Q000494:pharmacology*; D011726:Pyridinium Compounds / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013552:Swine
chemical_list: D002619:Chemical Warfare Agents; D002800:Cholinesterase Inhibitors; D002801:Cholinesterase Reactivators; D004800:Enzymes, Immobilized; D010755:Organophosphates; D010091:Oximes; D011726:Pyridinium Compounds; C005514:N,N'-monomethylenebis(pyridiniumaldoxime); D000110:Acetylcholinesterase; C009374:tabun