The effect of compound nutrients on stress-induced changes in serum IL-2, IL-6 and TNF-alpha levels in rats.
The effect of compound nutrients on serum concentrations of the cytokines, such as interleukin (IL)-2, tumor necrosis factor-alpha (TNF-alpha) and interleukin (IL)-6 in immobilization and cold water-immersion stressed rat were investigated. Oral (gavage) administration of compound nutrients was found to attenuate the acute and chronic immobilization and cold water-immersion stress-induced increase in serum IL-6 level and decrease in IL-2 level. Compound nutrients exerted different effects on TNF-alpha level in two different models studied, with reduced serum TNF-alpha level in acute stress, while no significant effect in chronic stress. These results suggested that compound nutrients might be proposed as a possible candidate in the research or therapeutic modulation of stress-related disorders.
Liu
Ya-Li
YL
Department of Physiology, The Fourth Military Medical University, Xi'an 710032, Shaanxi, China. yaliliu@fmmu.edu.cn
Bi
Hui
H
Chi
Su-Min
SM
Fan
Rong
R
Wang
Yue-Min
YM
Ma
Xin-Liang
XL
Chen
Yao-Ming
YM
Luo
Wen-Jing
WJ
Pei
Jian-Ming
JM
Chen
Jing-Yuan
JY
D000821:Animal Feed; D000818:Animals; D007376:Interleukin-2 / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013312:Stress, Physiological / Q000097:blood*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*
D007376:Interleukin-2; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha