title: A hypocaloric diet enriched in legumes specifically mitigates lipid peroxidation in obese subjects.
abstract: Legume intake could specifically protect against lipid peroxidation in addition to the effects associated to weight loss when included in hypocaloric diets. Thus, 30 obese subjects (age: 36 +/- 8 years and BMI: 32.0 +/- 5.3 kg/m(2)) were nutritionally treated by a 8-week energy restriction ( - 30% energy expenditure) with a legume enriched diet (4 days/week servings, [image omitted] ) or without legumes (control diet (CD), [image omitted] ). Body weight, circulating cholesterol, oxidized LDL (ox-LDL), malondialdehyde (MDA) and urinary 8-isoprostane F(2alpha) (8-iso-PGF(2alpha)) were measured at baseline and at endpoint. After the nutritional intervention, all obese subjects lost weight, specially those individuals who followed the legumes-enriched diet as compared to the CD ( - 7.7 +/- 3 vs. - 5.3 +/- 2.7%; p = 0.023), which was accompanied by marked decreases in total cholesterol levels (p < 0.001) and statistically significant diet-related reductions on plasma ox-LDL, plasma MDA and urinary 8-iso-PGF(2alpha) output. Therefore, a balanced diet with moderate caloric restriction including 4 day/week legume servings empowered the oxidative stress improvement related to weight loss through a reduction in lipid peroxidation as compared to a control hypocaloric diet.
authors: Department of Physiology and Nutrition, University of Navarra, Pamplona, Spain.
authors: Ana B
authors: AB
authors: Crujeiras
authors: Dolores
authors: D
authors: Parra
authors: Itziar
authors: I
authors: Abete
authors: J Alfredo
authors: JA
authors: Martínez
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000737:chemistry; D015992:Body Mass Index; D001835:Body Weight; D031204:Caloric Restriction; D002784:Cholesterol / Q000378:metabolism; D028441:F2-Isoprostanes / Q000378:metabolism; D007887:Fabaceae / Q000378:metabolism*; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000473:pathology*; D018384:Oxidative Stress
chemical_list: D000975:Antioxidants; D028441:F2-Isoprostanes; D002784:Cholesterol