Serum leptin and adiponectin are positively associated with bone mineral density at the distal radius in patients with type 2 diabetes mellitus.
There have been several reports about associations of serum leptin or adiponectin with bone mineral density and biochemical markers of bone turnover. However, the precise roles of adipocytokines in bone metabolism have not been fully elucidated. We investigated the associations of serum level of leptin or adiponectin with bone mineral density, serum osteocalcin, and urinary N-terminal telopeptide of type I collagen (NTX) in 40 Japanese patients with type 2 diabetes mellitus. Bone mineral density was measured by using dual-energy x-ray absorptiometry at different sites (distal radius, femoral neck, and lumbar spine) and was expressed as z score. Multiple regression analysis revealed that there were significant positive correlations between serum leptin or adiponectin level and z score at the distal radius, but not at the femoral neck or the lumbar spine. Although no correlation was observed between serum leptin and serum osteocalcin, there was a significant negative correlation between serum leptin and urinary NTX, a marker of bone resorption. No correlation was observed between serum adiponectin and serum osteocalcin or urinary NTX. These results indicate that leptin and adiponectin may have a protective effect on bone metabolism in patients with type 2 diabetes mellitus.
Tamura
Tomoko
T
Department of Molecular and Internal Medicine, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan.
Yoneda
Masayasu
M
Yamane
Kiminori
K
Nakanishi
Shuhei
S
Nakashima
Reiko
R
Okubo
Masamichi
M
Kohno
Nobuoki
N
D015502:Absorptiometry, Photon; D052242:Adiponectin / Q000097:blood; D015992:Body Mass Index; D015519:Bone Density / Q000502:physiology*; D024042:Collagen Type I / Q000652:urine; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000378:metabolism / Q000652:urine; D005260:Female; D005272:Femur Neck / Q000378:metabolism; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D020738:Leptin / Q000097:blood*; D008159:Lumbar Vertebrae / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D015675:Osteocalcin / Q000097:blood; D010455:Peptides / Q000652:urine; D011884:Radius / Q000378:metabolism; D012044:Regression Analysis
D052242:Adiponectin; D024042:Collagen Type I; D006442:Glycated Hemoglobin; D020738:Leptin; D015675:Osteocalcin; D010455:Peptides; C499918:ADIPOQ protein, human; C052929:collagen type I trimeric cross-linked peptide