Interferon-alpha is effective for CD4(+), CCR4(-) mycosis fungoides.
Mycosis fungoides (MF), a cutaneous T-cell lymphoma, is usually characterized by cell features of T-helper-2 (Th2) lymphocytes. MF has recently been reported to show increased CCR4 expression, a chemokine receptor specifically expressed in Th2. Previously, we have reported the effectiveness of interferon-gamma (IFN-gamma) for the treatment of CCR4(+) MF. In this report, we describe two cases of CD4(+), CCR4(-) MF successfully treated with IFN-alpha, but not IFN-gamma. Although MF usually displays a Th2 profile, the tumor cells in our two cases did not express CCR4. Our cases suggest the effectiveness of IFN-alpha, but not IFN-gamma, for CCR4- MF.
Fujimura
Taku
T
Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan. fujimura@gonryo.med.tohoku.ac.jp
Okuyama
Ryuhei
R
Watabe
Akiko
A
Hashimoto
Akira
A
Tagami
Hachiro
H
Aiba
Setsuya
S
D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D015496:CD4-Positive T-Lymphocytes / Q000378:metabolism; D003937:Diagnosis, Differential; D004890:Erythema / Q000209:etiology; D006801:Humans; D007279:Injections, Subcutaneous; D016898:Interferon-alpha / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000097:blood / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D054398:Receptors, CCR4; D019707:Receptors, Chemokine / Q000378:metabolism
D000970:Antineoplastic Agents; C515354:CCR4 protein, human; D016898:Interferon-alpha; D054398:Receptors, CCR4; D019707:Receptors, Chemokine