title: The circulating PBEF/NAMPT/visfatin level is associated with a beneficial blood lipid profile.
abstract: Visfatin with the official gene name pre-B cell colony-enhancing factor 1 (PBEF) and the protein name nicotinamide phosphoribosyltransferase (NAMPT) is a recently discovered adipocyte-secreted protein that was shown by some to be associated with visceral fat and insulin resistance. To explore the link between PBEF/NAMPT/visfatin and lipid metabolism, we analyzed the relation of its plasma level with several parameters of adiposity, insulin resistance and the circulating blood lipid profile in a group of general population (n = 40) and a group of subjects who are genetically predisposed to insulin resistance and hyperlipidemia (n = 35). In both groups and pooled cohort, PBEF/NAMPT/visfatin lacked association with whole body adiposity, but correlated positively with HDL-cholesterol and negatively with triglycerides. The data suggested a negative correlation of the PBEF level with visceral fat and insulin resistance. But this negative correlation completely disappeared after adjustment for lipid profile. We concluded that circulating PBEF/NAMPT/visfatin level is an indicator of beneficial lipid profile in non-diabetic Caucasian subjects. The relation to lipid metabolism does not depend on visceral obesity and insulin resistance, but may be linked to its enzymatic function in NAD metabolism.
authors: Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, P.O. Box 616, 6200 MD, Maastricht, The Netherlands.
authors: Ping
authors: P
authors: Wang
authors: Marleen M J
authors: MM
authors: van Greevenbroek
authors: Freek G
authors: FG
authors: Bouwman
authors: Martijn C G J
authors: MC
authors: Brouwers
authors: Carla J H
authors: CJ
authors: van der Kallen
authors: Egbert
authors: E
authors: Smit
authors: Jaap
authors: J
authors: Keijer
authors: Edwin C M
authors: EC
authors: Mariman
mesh_terms: D050154:Adiposity / Q000502:physiology; D000328:Adult; D001827:Body Height / Q000502:physiology; D015992:Body Mass Index; D001835:Body Weight / Q000502:physiology; D008076:Cholesterol, HDL / Q000097:blood; D016207:Cytokines / Q000378:metabolism*; D005260:Female; D006801:Humans; D006950:Hyperlipidemia, Familial Combined / Q000235:genetics / Q000378:metabolism; D007333:Insulin Resistance; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D054409:Nicotinamide Phosphoribosyltransferase / Q000378:metabolism*; D014280:Triglycerides / Q000097:blood
chemical_list: D008076:Cholesterol, HDL; D016207:Cytokines; D008055:Lipids; D014280:Triglycerides; D054409:Nicotinamide Phosphoribosyltransferase; C085455:nicotinamide phosphoribosyltransferase, human