Neurobehavioral alterations in rats exposed to acrylonitrile in drinking water.
This study was carried out on rodents, to explore the neurobehavioral effects of acrylonitrile (AN) administered in drinking water. Thirty, male, Sprague-Dawley rats were randomly divided into three groups: two exposure groups (50 and 200 ppm AN), and one control group (tap water without AN). Three tests, including the open field test, rotarod test and spatial water maze, were applied to evaluate locomotor activities, motor co-ordination and learning and memory, respectively, prior to initiation of the treatment, and at Week 4, 8 and 12 postexposure. There were no consistent changes in the open field test, except for locomotion and grooming episodes. In the rotarod test, AN significantly decreased the latencies to fall in a dose and time-dependent manner. In the spatial water maze test, rats exposed to AN for 12 weeks had significantly more training times and longer escape latencies than control animals. These findings indicate that oral exposure to AN induces neurobehavioral alterations in rats.
Rongzhu
L
L
Department of Preventive Medicine, School of Medicine, Jiangsu University, 3 Yizheng Road, Zhenjiang, Jiangsu 212001, China. lurz100@yahoo.com
Suhua
W
W
Guangwei
X
X
Fangan
H
H
Ziqiang
C
C
Fusheng
J
J
Kacew
S
S
D000181:Acrylonitrile / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000633:toxicity*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D002273:Carcinogens / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000633:toxicity; D005106:Exploratory Behavior / Q000187:drug effects; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D013861:Thiocyanates / Q000652:urine; D014867:Water / Q000008:administration & dosage
D002273:Carcinogens; D013861:Thiocyanates; D014867:Water; D000181:Acrylonitrile; C031760:thiocyanate