Relationship between serum IL-7 concentrations and lymphopenia upon different levels of HIV immune control.
Serum IL-7 levels correlate with T-cell depletion in HIV-infected individuals. In some patients, we observed that serum IL-7 decreases upon progression to AIDS, suggesting a role for IL-7 in T-cell maintenance in sporadic cases. Interestingly, IL-7 levels were significantly lower in stable long-term non-progressors (LTNP) than in patients who lost the LTNP status in a 3-year follow-up (P < 0.001), indicating that the serum IL-7 concentration might be a valuable marker for maintenance of the LTNP state.
Fluur
Caroline
C
Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
Rethi
Bence
B
Thang
Pham Hong
PH
Vivar
Nancy
N
Mowafi
Frida
F
Lopalco
Lucia
L
Foppa
Caterina Uberti
CU
Karlsson
Anders
A
Tambussi
Giuseppe
G
Chiodi
Francesca
F
D015415:Biomarkers / Q000097:blood; D018791:CD4 Lymphocyte Count; D005500:Follow-Up Studies; D015658:HIV Infections / Q000276:immunology*; D020276:HIV Long-Term Survivors; D015497:HIV-1; D006801:Humans; D015851:Interleukin-7 / Q000097:blood*; D018655:Lymphocyte Count; D008231:Lymphopenia / Q000276:immunology* / Q000821:virology
D015415:Biomarkers; D015851:Interleukin-7