title: Discovery of new C3aR ligands. Part 2: amino-piperidine derivatives.
abstract: The synthesis and structure-activity relationships against the C3a receptor of a series of substituted aminopiperidine derivatives are reported. DMPK properties and functional activities of selected compounds are described. The compounds obtained are the first non-arginine ligands of C3aR.
authors: UCB Global Chemistry, Chemin du Foriest, R4, 1420 Braine l'Alleud, Belgium. frederic.denonne@ucb-group.com
authors: Frédéric
authors: F
authors: Denonne
authors: Sophie
authors: S
authors: Binet
authors: Maggi
authors: M
authors: Burton
authors: Philippe
authors: P
authors: Collart
authors: Sabine
authors: S
authors: Defays
authors: Alan
authors: A
authors: Dipesa
authors: Maria
authors: M
authors: Eckert
authors: Alexander
authors: A
authors: Giannaras
authors: Seema
authors: S
authors: Kumar
authors: Beth
authors: B
authors: Levine
authors: Jean-Marie
authors: JM
authors: Nicolas
authors: Patrick
authors: P
authors: Pasau
authors: Cécile
authors: C
authors: Pégurier
authors: Dorin
authors: D
authors: Preda
authors: Nathalie
authors: N
authors: Van houtvin
authors: Andrew
authors: A
authors: Volosov
authors: Dong
authors: D
authors: Zou
mesh_terms: D000588:Amines / Q000737:chemistry*; D000818:Animals; D003167:Complement Activation / Q000187:drug effects*; D008024:Ligands; D008565:Membrane Proteins / Q000378:metabolism*; D051379:Mice; D008807:Mice, Inbred BALB C; D010880:Piperidines / Q000138:chemical synthesis / Q000494:pharmacology*; D011485:Protein Binding; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D011951:Receptors, Complement / Q000378:metabolism*; D013329:Structure-Activity Relationship
chemical_list: D000588:Amines; D008024:Ligands; D008565:Membrane Proteins; D010880:Piperidines; D011951:Receptors, Complement; C085567:complement C3a receptor; D017346:Protein Serine-Threonine Kinases