title: Topical bromfenac sodium for long-term management of vernal keratoconjunctivitis.
abstract: OBJECTIVE
  We evaluated the efficacy and safety of long-term management of patients with vernal keratoconjunctivitis (VKC) with bromfenac sodium eye drops in combination with corticosteroids and anti-allergic eye drops.
  
  
  METHODS
  Twenty-two patients with VKC were randomly assigned to receive two test eye drops, either bromfenac sodium 0.1% (group A) or placebo eye drops (normal saline; group B) for a mean observation period of 20.9 months. Topical corticosteroids and mast cell stabilizers were continued during the observation period.
  
  
  RESULTS
  The mean 2-year recurrence rate was 90.9% in group A and 11.3% in group B, with a significant difference. No serious side effect was observed in group A.
  
  
  CONCLUSIONS
  These results suggest that bromfenac sodium eye drops can be used as baseline local treatment in patients with VKC.
authors: Department of Ophthalmology, Fukuoka University School of Medicine, Fukuoka, Japan. euchio@fukuoka-u.ac.jp
authors: Eiichi
authors: E
authors: Uchio
authors: Yuki
authors: Y
authors: Itoh
authors: Kazuaki
authors: K
authors: Kadonosono
mesh_terms: D000293:Adolescent; D000328:Adult; D018926:Anti-Allergic Agents / Q000008:administration & dosage; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D001577:Benzophenones / Q000008:administration & dosage*; D001969:Bromobenzenes / Q000008:administration & dosage*; D002648:Child; D002675:Child, Preschool; D003228:Conjunctiva / Q000187:drug effects / Q000473:pathology; D003233:Conjunctivitis, Allergic / Q000188:drug therapy* / Q000473:pathology; D003315:Cornea / Q000187:drug effects / Q000473:pathology; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000008:administration & dosage; D006801:Humans; D008297:Male; D009883:Ophthalmic Solutions; D012720:Severity of Illness Index; D013997:Time Factors; D016896:Treatment Outcome; D062367:ortho-Aminobenzoates / Q000008:administration & dosage
chemical_list: D018926:Anti-Allergic Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001577:Benzophenones; D001969:Bromobenzenes; D005938:Glucocorticoids; D009883:Ophthalmic Solutions; D062367:ortho-Aminobenzoates; C053083:bromfenac; C012293:tranilast