An unusual cause of neonatal coagulopathy and liver disease.
Congenital thyrotoxicosis is a rare and potentially fatal illness. We report a case in a preterm infant delivered to a mother known to have autoimmune endocrine disease. Diagnosis was difficult because the infant's presenting symptoms and signs closely resembled congenital viral infection with co-existent hepatic dysfunction and coagulopathy. The associated hepatic dysfunction was so severe that liver biopsy was scheduled before the diagnosis emerged. A high degree of clinical suspicion coupled with prenatal identification of pregnancies at risk of complication by congenital thyrotoxicosis is imperative to facilitate prompt diagnosis and treatment.
Dryden
C
C
Neonatal Unit, Princess Royal Maternity, Glasgow, Scotland, UK. crdryden@hotmail.com
Simpson
J H
JH
Hunter
L E
LE
Jackson
L
L
D013956:Antithyroid Agents / Q000627:therapeutic use; D002231:Carbimazole / Q000627:therapeutic use; D003937:Diagnosis, Differential; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D006529:Hepatomegaly / Q000151:congenital*; D006801:Humans; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000175:diagnosis* / Q000188:drug therapy; D007452:Iodates / Q000627:therapeutic use; D008111:Liver Function Tests; D008875:Middle Aged; D016884:Polyendocrinopathies, Autoimmune / Q000175:diagnosis*; D017680:Potassium Compounds / Q000627:therapeutic use; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis*; D011433:Propranolol / Q000627:therapeutic use; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000151:congenital* / Q000175:diagnosis; D013163:Splenomegaly / Q000151:congenital*; D013960:Thyroid Function Tests; D013971:Thyrotoxicosis / Q000151:congenital* / Q000175:diagnosis* / Q000188:drug therapy
D013956:Antithyroid Agents; D007452:Iodates; D017680:Potassium Compounds; D002231:Carbimazole; D011433:Propranolol; C039693:potassium iodate