title: The fibrinogen gamma (FGG) 10034C>T polymorphism is associated with venous thrombosis.
abstract: BACKGROUND
  Thrombin-induced conversion of fibrinogen to fibrin plays an essential role in hemostasis and results in the stabilization of thrombi. Elevated plasma fibrinogen levels have been associated with both increased plasma viscosity and platelet aggregability. Recently, a haplotype-tagging single nucleotide polymorphism characterized by a C to T substitution at nucleotide 10034 of the fibrinogen gamma gene (FGG 10034C>T, rs2066865), has been proposed as a novel risk factor for deep venous thrombosis (DVT). Aim of the present study was to provide further data on the role of the FGG 10034C>T polymorphism for DVT.
  
  
  METHODS
  FGG genotypes were determined by 5'-exonuclease assay (TaqMan) in 358 patients with documented DVT and a total of 783 control subjects.
  
  
  RESULTS
  In a multivariate analysis adjusting for age, sex, presence of factor V Leiden and carriage of prothrombin 20210A, homozygosity for the FGG 10034 TT genotype yielded an odds ratio of 2.01 (95% CI 1.23-3.31; p=0.006) for DVT.
  
  
  CONCLUSIONS
  Our data confirm the primary finding that the FGG 10034C>T polymorphism is associated with DVT risk.
authors: Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University Graz, 8036 Graz Austria.
authors: Gerda
authors: G
authors: Grünbacher
authors: Wolfgang
authors: W
authors: Weger
authors: Ernestine
authors: E
authors: Marx-Neuhold
authors: Ernst
authors: E
authors: Pilger
authors: Herwig
authors: H
authors: Köppel
authors: Thomas
authors: T
authors: Wascher
authors: Winfried
authors: W
authors: März
authors: Wilfried
authors: W
authors: Renner
mesh_terms: D000328:Adult; D000368:Aged; D001317:Austria / Q000453:epidemiology; D016022:Case-Control Studies; D004252:DNA Mutational Analysis; D005260:Female; D005340:Fibrinogen / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D020246:Venous Thrombosis / Q000235:genetics*
chemical_list: D005340:Fibrinogen