The influence of psychoemotional status on metastasis of Lewis lung carcinoma and hepatocarcinoma-29 in mice of C57BL/6J and CBA/Lac strains.
OBJECTIVE
To study the influence of psychoemotional status on the development of experimental lung metastases of strain-specific murine Lewis lung carcinoma in C57BL/6J mice and hepatocarcinoma-29 in CBA/Lac male mice.


METHODS
Sensory contact model was used for generating animals with repeated experience of social victories or defeat in daily agonistic interactions. Tumor cells were injected into the tail vein after 20 days of aggressive confrontations and the number of metastases in the lung was calculated 16 days later.


RESULTS
The experimental metastasis is shown to develop differently in mice with opposing social experience: the winners of both strains had significantly less metastases in the lung than the losers.


CONCLUSIONS
The results obtained indicate that psychoemotional status affects Lewis lung carcinoma and hepatocarcinoma-29 metastasis in male mice.
Kudryavtseva
N N
NN
Institute of Cytology and Genetics of Siberian Department of the Russian Academy of Sciences, Novosibirsk, Russia. natnik@bionet.nsc.ru
Tenditnik
M V
MV
Nikolin
V P
VP
Popova
N A
NA
Kaledin
V I
VI
D000374:Aggression / Q000523:psychology*; D000818:Animals; D001007:Anxiety / Q000523:psychology*; D006528:Carcinoma, Hepatocellular / Q000523:psychology*; D018827:Carcinoma, Lewis Lung / Q000523:psychology* / Q000556:secondary; D004291:Dominance-Subordination; D008113:Liver Neoplasms / Q000523:psychology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D012919:Social Behavior; D013045:Species Specificity