title: Plasmonic nanosensors for imaging intracellular biomarkers in live cells.
abstract: Here we present the first intracellular molecular imaging platform using multifunctional gold nanoparticles which incorporate both cytosolic delivery and targeting moieties on the same particle. The utility of these intracellular sensors was demonstrated by monitoring actin rearrangement in live fibroblasts. We observed a strong molecular specific optical signal associated with effective targeting of actin filaments. These multifunctional nanosensors can be adapted to target various intracellular processes especially where transfection or cytotoxic labels are not feasible.
authors: Department of Biomedical Engineering, University of Texas at Austin, Austin, Texas 78712, USA.
authors: Sonia
authors: S
authors: Kumar
authors: Nathan
authors: N
authors: Harrison
authors: Rebecca
authors: R
authors: Richards-Kortum
authors: Konstantin
authors: K
authors: Sokolov
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000032:analysis*; D015374:Biosensing Techniques; D005347:Fibroblasts / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D053768:Metal Nanoparticles; D051379:Mice; D046529:Microscopy, Electron, Transmission; D041681:NIH 3T3 Cells
chemical_list: D015415:Biomarkers; D006046:Gold