Circulating concentrations of adiponectin and tumor necrosis factor-alpha in gestational diabetes mellitus.
Adiponectin and tumor necrosis factor-alpha (TNF-alpha) have been implicated in insulin resistance and diabetes mellitus (DM). In the present study we investigated levels of adiponectin and TNF-alpha and their relationships with each other and metabolic factors in women with gestational DM (GDM). Thirty-four pregnant women with GDM and 31 pregnant women with normal glucose tolerance (NGT) were included in the study. Plasma adiponectin levels were lower in GDM than in NGT (36.9 +/- 6.7 vs. 61.3 +/- 13.0 ng/ml, p = 0.028). Serum TNF-alpha levels were increased in GDM compared with NGT (20.5 +/- 2.4 vs. 14.0 +/- 1.5 pg/ml, p = 0.042). After adjustment for pre-pregnancy and current body mass index (BMI), adiponectin levels correlated negatively with insulin resistance by homeostasis model assessment-insulin resistance (HOMA-IR) and 0-h and 1-h glucose both at glucose challenge test and oral glucose tolerance test in GDM. Adiponectin levels were correlated only with very low-density lipoprotein cholesterol and triglyceride levels in NGT. TNF-alpha levels were correlated with glycated hemoglobin in GDM. There was a significant positive correlation between TNF-alpha levels and pre-pregnancy and current BMI in GDM as well as NGT. HOMA-IR for adiponectin and pre-pregnancy BMI for TNF-alpha remained as significant determinants in multiple regression analyses. In conclusion, these data suggest that reduced adiponectin and increased TNF-alpha may be involved in the pathogenesis of GDM.
Altinova
Alev E
AE
Department of Endocrinology and Metabolism, Gazi University Faculty of Medicine, Ankara, Turkey. alevaltinova@yahoo.com
Toruner
Fusun
F
Bozkurt
Nuray
N
Bukan
Neslihan
N
Karakoc
Ayhan
A
Yetkin
Ilhan
I
Ayvaz
Goksun
G
Cakir
Nuri
N
Arslan
Metin
M
D052242:Adiponectin / Q000097:blood*; D000328:Adult; D015992:Body Mass Index; D016640:Diabetes, Gestational / Q000097:blood* / Q000378:metabolism*; D005260:Female; D005951:Glucose Tolerance Test; D006442:Glycated Hemoglobin; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007333:Insulin Resistance; D011247:Pregnancy; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*
D052242:Adiponectin; D006442:Glycated Hemoglobin; D006454:Hemoglobins; D014409:Tumor Necrosis Factor-alpha; C517652:hemoglobin A1c protein, human