Reactivation of immobilized acetylcholinesterase-tabun complex by methoxime and its homologues.
Using an immobilized acetylcholinesterase-tabun enzyme-inhibitor complex, the reactivation efficacy of a homologous series of bispyridinium reactivators with increasing length of the alkylene chain between the pyridinium rings has been studied. The number of the alkylene groups in the chain ranged from one to six. N,N'-Monomethylenebis(4-pyridiniumaldoxime) dibromide (MMB-4) and N,N'-trimethylenebis(4-pyridiniumaldoxime) dibromide (TMB-4) are the most efficient reactivators of the series.
Hoskovcová
Monika
M
University of Defence, Brno, Institute of NBC Defence, Vyskov, Czech Republic. monika.hoskovcova@unob.cz
Halámek
Emil
E
Kobliha
Zbynek
Z
Tusarová
Ivana
I
D000110:Acetylcholinesterase / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D002619:Chemical Warfare Agents / Q000633:toxicity; D002800:Cholinesterase Inhibitors / Q000633:toxicity; D002801:Cholinesterase Reactivators / Q000494:pharmacology*; D004800:Enzymes, Immobilized; D010755:Organophosphates / Q000633:toxicity; D010091:Oximes / Q000494:pharmacology*; D011726:Pyridinium Compounds / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013552:Swine
D002619:Chemical Warfare Agents; D002800:Cholinesterase Inhibitors; D002801:Cholinesterase Reactivators; D004800:Enzymes, Immobilized; D010755:Organophosphates; D010091:Oximes; D011726:Pyridinium Compounds; C005514:N,N'-monomethylenebis(pyridiniumaldoxime); D000110:Acetylcholinesterase; C009374:tabun