[Pathophysiology of systemic lupus erythematosus].
Innate immunity is directly implicated in the pathophysiology of lupus through the dendritic cell system and the activation by immune complexes of some toll-like receptors (TLR). Interferon-alpha plays a key role in the pathophysiology of lupus and represents a promising target for immune therapy. Dendritic cells are activated and able to capture large quantities of nuclear antigen-containing bodies to stimulate specific adaptive immune response.
Blanco
Patrick
P
Clinique de médecine interne, Hôpital Haut-Lévêque, Pessac, France. patrick.blanco@u-bordeaux2.fr
Pellegrin
Jean-Luc
JL
Moreau
Jean-François
JF
Viallard
Jean-François
JF
D000293:Adolescent; D000328:Adult; D000818:Animals; D000936:Antigen-Antibody Complex / Q000276:immunology; D034961:Antigens, Nuclear / Q000276:immunology; D017209:Apoptosis / Q000502:physiology; D001324:Autoantigens / Q000276:immunology; D015551:Autoimmunity / Q000276:immunology; D001402:B-Lymphocytes; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D002648:Child; D003713:Dendritic Cells / Q000276:immunology / Q000502:physiology; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D016898:Interferon-alpha / Q000502:physiology; D008180:Lupus Erythematosus, Systemic / Q000276:immunology / Q000503:physiopathology*; D008297:Male; D051379:Mice; D051193:Toll-Like Receptors / Q000502:physiology
D000936:Antigen-Antibody Complex; D034961:Antigens, Nuclear; D001324:Autoantigens; D016898:Interferon-alpha; D051193:Toll-Like Receptors