title: Paraneoplastic vasculitis of central nervous system presenting as recurrent cryptogenic stroke.
abstract: We report the case of paraneoplastic vasculitis of the central nervous system associated with breast cancer. A 54-year old woman had a complete workup because of recidive seizures. Magnetic resonance imaging (MRI) showed cerebral and medullary cryptogenic lesions, and a diagnosis of encephalomyelitis of unknown origin was made. She was treated with corticosteroids, but because of cognitive impairment and recurrence of epileptic seizures, she was finally transferred to our Neurology Department. The previous diagnosis was then changed, because a poorly differentiated invasive lobular breast cancer was discovered. Thoracic and abdominal computed tomography (CT) scans diagnosed pulmonary, pericardial, adrenal, and renal metastases. Because MRI findings did not fit with the diagnosis of brain metastases, a CT-guided cerebral biopsy was performed, and she was eventually diagnosed with paraneoplastic vasculitis of the central nervous system.
authors: Neurology Department, Erasme University Hospital, Route de Lennik, 808, 1070 Brussels, Belgium. ftaccone@ulb.ac.be
authors: Fabio Silvio
authors: FS
authors: Taccone
authors: Isabelle
authors: I
authors: Salmon
authors: Raphael
authors: R
authors: Marechal
authors: Serge A
authors: SA
authors: Blecic
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000556:secondary; D001943:Breast Neoplasms / Q000473:pathology; D018275:Carcinoma, Lobular / Q000473:pathology; D004827:Epilepsy / Q000209:etiology; D017809:Fatal Outcome; D005260:Female; D006338:Heart Neoplasms / Q000556:secondary; D006801:Humans; D007680:Kidney Neoplasms / Q000556:secondary; D008175:Lung Neoplasms / Q000556:secondary; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D020361:Paraneoplastic Syndromes, Nervous System / Q000150:complications* / Q000175:diagnosis; D010496:Pericardium / Q000473:pathology; D020521:Stroke / Q000209:etiology*; D014057:Tomography, X-Ray Computed; D020293:Vasculitis, Central Nervous System / Q000175:diagnosis / Q000209:etiology*