Testicular sperm extraction and ICSI in patients with post-chemotherapy non-obstructive azoospermia.
146 MD-TESE procedures were performed in 74 patients presenting with non-obstructive azoospermia (NOA). Five of the 74 patients displayed a history of chemotherapy. Etiology of chemotherapies included testicular cancer, osteosarcoma, Ewing sarcoma, and malignant lymphoma of the stomach. Post-chemotherapy duration was 2.5-18 years. All patients underwent MD-TESE using local anesthesia with spermatic block and sedation. Extracted sperm was cryopreserved for ICSI. Histopathologic examination revealed Sertoli cell-only syndrome in all five patients; however, sperm were retrieved in 3 subjects. Post-chemotherapy MD-TESE and ICSI can be applied successfully in some patients with NOA. However, freezing semen prior to chemotherapy is recommended.
Hibi
H
H
Department of Urology, Kyoritsu General Hospital, Nagoya, Japan. hibih@quartz.ocn.ne.jp
Ohori
T
T
Yamada
Y
Y
Honda
N
N
Hashiba
Y
Y
Asada
Y
Y
D000970:Antineoplastic Agents / Q000009:adverse effects*; D053713:Azoospermia / Q000139:chemically induced*; D005260:Female; D007839:Functional Laterality; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000188:drug therapy; D009919:Orchiectomy; D011247:Pregnancy; D011256:Pregnancy Outcome; D013048:Specimen Handling / Q000379:methods; D013075:Sperm Capacitation; D020554:Sperm Injections, Intracytoplasmic; D013737:Testis / Q000033:anatomy & histology
D000970:Antineoplastic Agents