Loss-of-function alleles of the JIL-1 histone H3S10 kinase enhance position-effect variegation at pericentric sites in Drosophila heterochromatin.
In this study we show that loss-of-function alleles of the JIL-1 histone H3S10 kinase act as enhancers of position-effect variegation at pericentric sites whereas the gain-of-function JIL-1(Su(var)3-1[3]) allele acts as a suppressor strongly supporting a functional role for JIL-1 in maintaining euchromatic chromatin and counteracting heterochromatic spreading and gene silencing.
Bao
Xiaomin
X
Department of Biochemistry, Biophysics, and Molecular Biology Iowa State University Ames, Iowa 50011, USA.
Deng
Huai
H
Johansen
Jørgen
J
Girton
Jack
J
Johansen
Kristen M
KM
D000818:Animals; D002843:Chromatin / Q000235:genetics; D002874:Chromosome Mapping; D004247:DNA / Q000235:genetics*; D004330:Drosophila / Q000235:genetics*; D029721:Drosophila Proteins / Q000235:genetics*; D020868:Gene Silencing; D017930:Genes, Reporter; D006570:Heterochromatin / Q000235:genetics*; D019656:Loss of Heterozygosity / Q000235:genetics*; D017346:Protein Serine-Threonine Kinases / Q000235:genetics*; D017384:Sequence Deletion
D002843:Chromatin; D029721:Drosophila Proteins; D006570:Heterochromatin; D004247:DNA; C507306:JIL-1 protein, Drosophila; D017346:Protein Serine-Threonine Kinases