title: Synergism of toxicity of N,N-diethyl-m-toluamide to German cockroaches (Orthoptera: Blattellidae) by hydrolytic enzyme inhibitors.
abstract: Various compounds were tested for effects on the toxicity of the insect repellent N, N-diethyl-m-toluamide (DEET) in German cockroaches, Blattella germanica (L.). Organophosphate and carbamate acetylcholinesterase inhibitors carbaryl, DEF, eserine (physostigmine, malathion and pyridostigmine bromide synergized DEET toxicity also synergized the toxicity of the formamidine pesticides. Amitraz and chlordimeform. Results suggest that DEET may have some toxic actions that are similar to those of formamidine pesticides. DEET synergized the toxicity of some acetylcholinesterase inhibitors but not others. Results further suggest that some mechanism other than acetylcholinesterase inhibition was responsible for the toxic interactions observed between DEET and the acetylcholinesterase inhibitors.
authors: Medical and Veterinary Entomology Research Laboratory, USDA-ARS, P.O. Box 14565, 1600 SW. 23rd Drive, Gainesville, FL 32604, USA.
authors: J I
authors: JI
authors: Moss
mesh_terms: D000818:Animals; D020048:Blattellidae; D002800:Cholinesterase Inhibitors / Q000633:toxicity*; D003671:DEET / Q000633:toxicity*; D004357:Drug Synergism; D007302:Insect Repellents / Q000633:toxicity*; D007306:Insecticides / Q000633:toxicity; D007928:Lethal Dose 50; D008297:Male; D023421:Models, Animal; D010830:Physostigmine / Q000633:toxicity
chemical_list: D002800:Cholinesterase Inhibitors; D007302:Insect Repellents; D007306:Insecticides; D003671:DEET; D010830:Physostigmine