No difference in leprosy treatment outcomes comparing 12- and 24-dose multidrug regimens: a preliminary study.
A comparative study was performed on the initial and final bacillary indexes of 213 multibacillary leprosy patients who received 12 doses (Group 1: 128 patients) or 24 doses (Group 2: 85 patients) of multidrug therapy (MDT/WHO) to measure the effectiveness of the two regimens. All patients were evaluated at treatment baseline, 12 months, and 24 months. The reduction in bacillary levels and mean bacillary indexes at 24 months was similar in the two groups. No statistical difference in reaction rates was observed between the two treatment regimens.
Sales
Anna Maria
AM
Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Av. Brasil 4365, Rio de Janeiro, RJ 21045-900, Brazil.
Sabroza
Paulo Chagastelles
PC
Nery
José Augusto da Costa
JA
Dupprè
Nádia Cristina
NC
Sarno
Euzenir Nunes
EN
D000328:Adult; D002985:Clinical Protocols; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007917:Leprostatic Agents / Q000008:administration & dosage*; D015440:Leprosy, Lepromatous / Q000188:drug therapy* / Q000382:microbiology; D016014:Linear Models; D008297:Male; D013997:Time Factors; D016896:Treatment Outcome
D007917:Leprostatic Agents