title: Ene-yne tetrahydrofurans from the sponge Xestospongia muta. exploiting a weak CD effect for assignment of configuration.
abstract: Seven new brominated ene-yne tetrahydrofurans (THFs), mutafurans A-G, were isolated from the Bahamian sponge Xestospongia muta. The absolute configuration of the natural products was assigned as (5R,8S) by interpretation of the Cotton effect arising from weak perturbation of an ene-yne chromophore by a propargylic THF ring.
authors: Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA.
authors: Brandon I
authors: BI
authors: Morinaka
authors: Colin K
authors: CK
authors: Skepper
authors: Tadeusz F
authors: TF
authors: Molinski
mesh_terms: D000818:Animals; D001966:Bromine / Q000737:chemistry; D002942:Circular Dichroism; D004952:Esters / Q000737:chemistry; D005231:Fatty Acids, Unsaturated / Q000737:chemistry; D005663:Furans / Q000737:chemistry*; D006859:Hydrogen / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D047131:Xestospongia / Q000737:chemistry*
chemical_list: D004952:Esters; D005231:Fatty Acids, Unsaturated; D005663:Furans; D006859:Hydrogen; D001966:Bromine