title: Lornoxicam and ondansetron for the prevention of intrathecal fentanyl-induced pruritus.
abstract: OBJECTIVE
  In this randomized, double-blind study, we aimed to compare the effectiveness of lornoxicam and ondansetron for the prevention of intrathecal fentanyl-induced pruritus in patients undergoing cesarean section.
  
  
  METHODS
  One hundred and eight parturients (American Society of Anesthesiologists [ASA] I-II status) requesting neuraxial analgesia by a combined spinal-epidural (CSE) technique were recruited for this study. A CSE technique was performed and anesthesia was achieved with fentanyl 25 microg and hyperbaric bupivacaine 12 mg. Patients were randomly allocated to three groups, each with 36 participants. Immediately following delivery, patients received either lornoxicam 8 mg IV (group L; n = 36), ondansetron 8 mg IV (group O; n = 36), or normal saline 2 ml IV (group P; n = 36). Pruritus, pain, and nausea and vomiting scores were recorded during the initial 24 h postoperatively.
  
  
  RESULTS
  The incidence of pruritus was significantly lower in group O from 4 to 12 h postoperatively when compared to that in group L and group P. According to the pruritus grading system we used, the number of patients without pruritus was significantly higher in group O when compared to that in group L and group P. The number of patients experiencing moderate pruritus was significantly lower in group O when compared to that in group P.
  
  
  CONCLUSIONS
  We observed that the administration of 8 mg IV lornoxicam failed to prevent intrathecal fentanyl-induced pruritus in parturients. Also, our data confirmed that ondansetron is likely to attenuate intrathecal fentanyl-induced pruritus.
authors: Department of Anesthesiology, Inonu University School of Medicine, Malatya, Turkey.
authors: Nurcin
authors: N
authors: Gulhas
authors: Feray Akgul
authors: FA
authors: Erdil
authors: Ozlem
authors: O
authors: Sagir
authors: Ender
authors: E
authors: Gedik
authors: Turkan
authors: T
authors: Togal
authors: Zekine
authors: Z
authors: Begec
authors: M Ozcan
authors: MO
authors: Ersoy
mesh_terms: D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D000982:Antipruritics / Q000627:therapeutic use*; D001034:Apgar Score; D002585:Cesarean Section; D004311:Double-Blind Method; D005260:Female; D005283:Fentanyl / Q000009:adverse effects*; D006801:Humans; D007231:Infant, Newborn; D017294:Ondansetron / Q000627:therapeutic use*; D010894:Piroxicam / Q000031:analogs & derivatives* / Q000627:therapeutic use; D011247:Pregnancy; D011537:Pruritus / Q000209:etiology* / Q000517:prevention & control*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000982:Antipruritics; D010894:Piroxicam; D017294:Ondansetron; C059451:lornoxicam; D005283:Fentanyl