Demographic histories and patterns of linkage disequilibrium in Chinese and Indian rhesus macaques.
To understand the demographic history of rhesus macaques (Macaca mulatta) and document the extent of linkage disequilibrium (LD) in the genome, we partially resequenced five Encyclopedia of DNA Elements regions in 9 Chinese and 38 captive-born Indian rhesus macaques. Population genetic analyses of the 1467 single-nucleotide polymorphisms discovered suggest that the two populations separated about 162,000 years ago, with the Chinese population tripling in size since then and the Indian population eventually shrinking by a factor of four. Using coalescent simulations, we confirmed that these inferred demographic events explain a much faster decay of LD in Chinese (r(2) approximately 0.15 at 10 kilobases) versus Indian (r(2) approximately 0.52 at 10 kilobases) macaque populations.
Hernandez
Ryan D
RD
Biological Statistics and Computational Biology, Cornell University, Ithaca, NY 14850, USA.
Hubisz
Melissa J
MJ
Wheeler
David A
DA
Smith
David G
DG
Ferguson
Betsy
B
Rogers
Jeffrey
J
Nazareth
Lynne
L
Indap
Amit
A
Bourquin
Traci
T
McPherson
John
J
Muzny
Donna
D
Gibbs
Richard
R
Nielsen
Rasmus
R
Bustamante
Carlos D
CD
D000818:Animals; D002681:China; D004272:DNA, Mitochondrial; D003710:Demography; D005826:Genetics, Medical; D006801:Humans; D007194:India; D015810:Linkage Disequilibrium; D008253:Macaca mulatta / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
D004272:DNA, Mitochondrial