NCX current in the murine embryonic heart: development-dependent regulation by Na+.
Due to its high functional expression, I(NCX) may serve as an important mechanism to ensure intracellular Ca2+ homeostasis, especially during the early embryonic stage. At the fetal stage I(NCX) density is significantly decreased but underlies regulatory processes, that is, regulation by Na+.
Reppel
Michael
M
Institute of Neurophysiology, University of Cologne, Robert-Koch-Str. 39, D-50931 Cologne, Germany. akp72@uni-koeln.de
Reuter
Hannes
H
Sasse
Philipp
P
Hescheler
Jürgen
J
Fleischmann
Bernd K
BK
D000818:Animals; D002478:Cells, Cultured; D047108:Embryonic Development; D006321:Heart / Q000196:embryology* / Q000502:physiology*; D006706:Homeostasis; D051379:Mice; D012964:Sodium / Q000378:metabolism*; D019831:Sodium-Calcium Exchanger / Q000502:physiology*
D019831:Sodium-Calcium Exchanger; D012964:Sodium