title: Giant cell tumor complicating Paget disease of long bone.
abstract: Giant cell tumor (GCT) is a rare complication of Paget disease of bone. It usually occurs in the skull or pelvic bones of patients with long-standing polyostotic disease. This report describes a 62-year-old patient who presented with monostotic Paget disease of the distal femur complicated by GCT. He had a 2-year history of discomfort and pain in his left knee. Conventional plain films and MRI demonstrated the characteristic bone changes of Paget disease and an associated lytic lesion involving the epiphyseal and metaphyseal regions of the distal femur. A diagnostic curettage showed the characteristic histopathologic features of Paget disease and GCT. There was no evidence of malignancy. The clinicopathologic features of this rare lesion are described and correlated with a review of the literature.
authors: Department of Pathology, Mount Sinai Medical Center, One Gustave L. Levy Place, Box 1194, New York, NY 07422, USA. benjamin.hoch@mountsinai.org
authors: Benjamin
authors: B
authors: Hoch
authors: George
authors: G
authors: Hermann
authors: Michael J
authors: MJ
authors: Klein
authors: Ibrahim Fikry
authors: IF
authors: Abdelwahab
authors: Dempsey
authors: D
authors: Springfield
mesh_terms: D018286:Carcinoma, Giant Cell / Q000150:complications* / Q000175:diagnosis*; D005266:Femoral Neoplasms / Q000150:complications* / Q000175:diagnosis*; D005269:Femur / Q000000981:diagnostic imaging / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010001:Osteitis Deformans / Q000150:complications* / Q000175:diagnosis*; D011859:Radiography