Effects of isoflurane on Tei-index of myocardial performance in healthy dogs.
Recently, the Tei-index, a noninvasive index that combines systolic and diastolic time intervals, has been proposed to assess global cardiac performance. However, the effects of isoflurane on the Tei-index have not been characterized. This study aimed at studying the effects of 1.0 minimal alveolar concentration isoflurane anesthesia on the pre-ejection period (PEP), left ventricular ejection time (LVET), PEP/LVET ratio, isovolumic relaxation time (IVRT), stroke index (SI), cardiac index (CI), heart rate (HR), and the Tei-index in healthy unpremedicated dogs. We observed significant increases in PEP, PEP/LVET ratio, IVRT, and TEI, whose maximal increases obtained throughout the study were 47%, 48%, 78%, and 56%, respectively. The LVET and HR did not change significantly, whereas the SI and CI decreased during anesthesia (29% and 26%, respectively). In conclusion, isoflurane produced direct effects on the Tei-index. The changes in systolic and diastolic parameters were supportive of this finding and were consistent with an overall impairment of left ventricular function during anesthesia.
Sousa
Marlos Gonçalves
MG
Departamento de Clínica e Cirurgia Veterinária, Faculdade de Ciências Agrárias e Veterinárias, Universidade Estadual Paulista , Via de Acesso Professor Paulo Donato Castellane, s/no, Jaboticabal, São Paulo, Brazil.
Carareto
Roberta
R
De-Nardi
Andrigo Barboza
AB
Brito
Fábio L C
FL
Nunes
Newton
N
Camacho
Aparecido Antonio
AA
D018685:Anesthetics, Inhalation / Q000494:pharmacology*; D000818:Animals; D003971:Diastole / Q000502:physiology; D004285:Dogs / Q000502:physiology*; D004452:Echocardiography / Q000662:veterinary; D005260:Female; D006321:Heart / Q000502:physiology*; D006334:Heart Function Tests / Q000662:veterinary*; D006339:Heart Rate; D007530:Isoflurane / Q000494:pharmacology*; D008297:Male; D013599:Systole / Q000502:physiology
D018685:Anesthetics, Inhalation; D007530:Isoflurane