Molecular mechanism of insulin resistance.
Free fatty acids are known to play a key role in promoting loss of insulin sensitivity,thereby causing insulin resistance and type 2 diabetes.However,the underlying mechanism involved is still unclear.In searching for the cause of the mechanism,it has been found that palmitate inhibits insulin receptor (IR)gene expression,leading to a reduced amount of IR protein in insulin target cells. PDK1-independent phosphorylation of PKC(eta) causes this reduction in insulin receptor gene expression.One of the pathways through which fatty acid can induce insulin resistance in insulin target cells is suggested by these studies.We provide an overview of this important area,emphasizing the current status.
Bhattacharya
Samir
S
Cellular and Molecular Endocrinology Laboratory, Department of Zoology, School of Life Science, Visva-Bharati (A Central University), Santiniketan 731 235, India. smrbhattacharya@yahoo.co.in
Dey
Debleena
D
Roy
Sib Sankar
SS
D005230:Fatty Acids, Nonesterified / Q000378:metabolism*; D005786:Gene Expression Regulation / Q000502:physiology*; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D007333:Insulin Resistance / Q000502:physiology*; D008954:Models, Biological; D010766:Phosphorylation; D011493:Protein Kinase C / Q000378:metabolism; D011972:Receptor, Insulin / Q000378:metabolism* / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*
D005230:Fatty Acids, Nonesterified; D007328:Insulin; C087857:protein kinase C gamma; D011972:Receptor, Insulin; D011493:Protein Kinase C