MR findings of intrathecal chemotherapy-related myelopathy in two cases: mimicker of subacute combined degeneration.
We report the findings of spinal magnetic resonance imaging (MRI) in 2 patients who had undergone intrathecal chemotherapy and presented with the subacute onset of ascending numbness and weakness. MRI revealed a symmetric hyperintensity at the posterior columns of the spinal cord from the lower cervical region down to the conus medullaris level on T2-weighted images, and no abnormal enhancement. The imaging findings are similar to those seen in subacute combined degeneration (SCD), but the serum vitamin B(12) levels were normal in these 2 cases.
Lu
Chia-Hung
CH
Department of Medical Imaging, National Taiwan University Hospital, Taipei, Taiwan.
Yao
Ming
M
Liu
Hon-Man
HM
Chen
Ya-Fang
YF
D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D016393:Lymphoma, B-Cell / Q000188:drug therapy; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy; D013118:Spinal Cord Diseases / Q000139:chemically induced* / Q000175:diagnosis*; D052879:Subacute Combined Degeneration / Q000175:diagnosis
D000970:Antineoplastic Agents