Paraoxonase, total antioxidant activity and peroxide levels in marasmic children: relationships with leptin.
OBJECTIVE
The aim of this study was to investigate the oxidant/antioxidant status, paraoxonase (PON) activity and leptin levels in children with marasmic malnutrition.


METHODS
Thirty marasmic children (age 14.4+/-10.3 months) and 28 control subjects were included. Plasma PON activity, total antioxidant activity (TAO), total peroxide (TPX) and leptin levels were measured.


RESULTS
Malnourished children had significantly lower leptin (3.6+/-1.1 vs. 11.8+/-4.5 ng/mL, P<0.001), PON activity (66.4+/-28.6 vs. 221.3+/-31.6 IU/L, P<0.001) and TAO (1.44+/-0.12 vs. 2.45+/-0.61 mmol Trolox equiv/L, P<0.001); and higher TPX (15.6+/-6.4 vs. 5.9+/-1.9 micromol/L, P<0.001) values than in controls. Significant negative correlation was found between PON and TPX (P=0.040) and positive correlation between TAO and BMI (P=0.034) in patients. No significant correlation was found between leptin and oxidant/antioxidant parameters (P>0.05).


CONCLUSIONS
Children with marasmic malnutrition had increased pro-oxidant and decreased antioxidant status. Extent of oxidative stress increases with malnutrition severity. Antioxidants could be given during nutritional rehabilitation.
Ece
Aydin
A
Department of Pediatrics, Dicle University, Medical School, Diyarbakir, Turkey. aydece@dicle.edu.tr
Gürkan
Fuat
F
Celik
Fatma
F
Boşnak
Mehmet
M
Yel
Servet
S
Balik
Hasan
H
Erel
Ozcan
O
D000975:Antioxidants / Q000032:analysis*; D043303:Aryldialkylphosphatase / Q000097:blood*; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D020738:Leptin / Q000097:blood*; D008055:Lipids / Q000097:blood; D008297:Male; D018384:Oxidative Stress / Q000502:physiology; D010545:Peroxides / Q000097:blood*; D011502:Protein-Energy Malnutrition / Q000503:physiopathology*
D000975:Antioxidants; D020738:Leptin; D008055:Lipids; D010545:Peroxides; D043303:Aryldialkylphosphatase