title: Chemomicin A, a new angucyclinone antibiotic produced by Nocardia mediterranei subsp. kanglensis 1747-64.
abstract: A new angucyclinone antibiotic, chemomicin A was isolated from cultured broth of Nocardia mediterranei subsp. kanglensis 1747-64. Its chemical structure was determined to be 1,2,3,4a,5,6,6a,12a,12b-nonahydro-1,2,3,8,12,12b-hexahydroxy-3-methyl-6a,12a-epoxybenz[a]anthracen-4,7(12H)-dione by a detailed spectroscopic analysis. Chemomicin A had antimicrobial activity against Bacillus subtilis and Enterococcus faecium with MIC values of 10.2 and 20.4 microM, respectively, and showed cytotoxicity against human colorectal cancer HCT116 cells and human esophageal carcinoma YES-2 cells with IC50 values of 127 and 153 microM, respectively.
authors: Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, PR China. chenghangsun@hotmail.com
authors: Cheng-Hang
authors: CH
authors: Sun
authors: Yue
authors: Y
authors: Wang
authors: Zheng
authors: Z
authors: Wang
authors: Jian-Qin
authors: JQ
authors: Zhou
authors: Wen-Zao
authors: WZ
authors: Jin
authors: Xue-Fu
authors: XF
authors: You
authors: Hong
authors: H
authors: Gao
authors: Li-Xun
authors: LX
authors: Zhao
authors: Shu-Yi
authors: SY
authors: Si
authors: Xue
authors: X
authors: Li
mesh_terms: D000880:Anthraquinones / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology; D001412:Bacillus subtilis / Q000187:drug effects*; D045744:Cell Line, Tumor; D016984:Enterococcus faecium / Q000187:drug effects*; D005285:Fermentation; D006801:Humans; D020128:Inhibitory Concentration 50; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009615:Nocardia / Q000145:classification / Q000254:growth & development / Q000378:metabolism*
chemical_list: D000880:Anthraquinones; D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; C510997:angucyclinone; C520923:chemomicin A