title: Intrasubject medication adherence patterns.
abstract: The purpose of this prospective descriptive study was to explore the patterns of intrasubject (between medication) adherence of two similarly timed, twice-daily medications using the Medication Event Management System electronic monitoring cap. Medication adherence was measured for 6 months using electronic monitoring in 25 adult renal-transplant recipients. Data were available from 7,119 electronic medication events. Results indicated that two twice-daily medications scheduled to be taken simultaneously were taken within 5 min of each other 77% of the time and within 10 min, 92% of the time. When only the first scheduled dose of the day was examined, the results are 79% and 95%, respectively. These findings are important to researchers and clinicians who must evaluate medication adherence in transplant recipients while balancing cost and subject burden. This study provides empirical support for monitoring a single immunosuppressive medication electronically to estimate medication adherence with double or triple immunosuppressive drug therapy.
authors: University of Missouri-Columbia, USA.
authors: Cynthia L
authors: CL
authors: Russell
authors: Vicki S
authors: VS
authors: Conn
authors: Catherine
authors: C
authors: Ashbaugh
authors: Richard
authors: R
authors: Madsen
authors: Karen
authors: K
authors: Hayes
authors: Gilbert
authors: G
authors: Ross
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D016030:Kidney Transplantation / Q000451:nursing*; D008297:Male; D008509:Medication Systems; D008875:Middle Aged; D015146:Midwestern United States; D010349:Patient Compliance; D011446:Prospective Studies
chemical_list: D007166:Immunosuppressive Agents