title: Gastrointestinal manifestations in patients with common variable immunodeficiency.
abstract: This study focuses on endoscopic and pathologic alterations of gastrointestinal (GI) disorders of Iranian patients with common variable immunodeficiency (CVID). Nineteen of 39 CVID patients (48%) had GI complaints. The most common symptom was chronic diarrhea (28%). In endoscopic examination of small intestines, 15 patients had no abnormal finding. Duodenal biopsy revealed villous atrophy in eight and nodular lymphoid hyperplasia in three patients. There was no statistically significant difference between patients with and patients without duodenal villous atrophy regarding the presence of chronic diarrhea, anemia, and absolute CD4+T cells. In three patients, biopsies of the colon showed chronic noncrypt-destructive colitis. GI problems pose a high morbidity to CVID patients and are second only to respiratory complications. CVID patients are at increased risk of infectious and inflammatory conditions in the GI tract. Early diagnosis of these complications improves the quality of life and well-being of patients.
authors: Department of Pediatrics, Division of Gastroenterology, Children's Medical Center Hospital, Tehran University of Medical Sciences, Tehran, Iran.
authors: Ahmad
authors: A
authors: Khodadad
authors: Asghar
authors: A
authors: Aghamohammadi
authors: Nima
authors: N
authors: Parvaneh
authors: Nima
authors: N
authors: Rezaei
authors: Fatemeh
authors: F
authors: Mahjoob
authors: Mohammad
authors: M
authors: Bashashati
authors: Masoud
authors: M
authors: Movahedi
authors: Mohammad Reza
authors: MR
authors: Fazlollahi
authors: Fariborz
authors: F
authors: Zandieh
authors: Zahra
authors: Z
authors: Roohi
authors: Sina
authors: S
authors: Abdollahzade
authors: Ali
authors: A
authors: Salavati
authors: Ali
authors: A
authors: Kouhi
authors: Bahram
authors: B
authors: Talebpour
authors: Nasser Ebrahimi
authors: NE
authors: Daryani
mesh_terms: D000293:Adolescent; D000328:Adult; D001706:Biopsy; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D002648:Child; D003106:Colon / Q000473:pathology; D017074:Common Variable Immunodeficiency / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology; D003937:Diagnosis, Differential; D016099:Endoscopy, Gastrointestinal; D005260:Female; D005500:Follow-Up Studies; D005767:Gastrointestinal Diseases / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D006801:Humans; D007136:Immunoglobulins / Q000097:blood; D015994:Incidence; D007421:Intestine, Small / Q000473:pathology; D007492:Iran / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011788:Quality of Life; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors
chemical_list: D007136:Immunoglobulins