title: In situ generation of chiral N-dienyl lactams in a multicomponent reaction: an efficient and highly selective way to asymmetric amidocyclohexenes.
abstract: Chiral N-dienyl lactams are crucial building blocks for the synthesis of complex organic compounds. However, their generation is rather challenging. This paper reports on a highly efficient and diastereoselective multicomponent methodology utilizing chiral amides, aldehydes, and dienophiles (AAD reaction). The three components readily react under in situ generation of chiral N-dienyl lactams which undergo a subsequent Diels-Alder reaction. Different chiral amides have been employed in the standard protocol delivering yields up to 94%, and selectivities up to 90% de. Moreover, DFT calculations were performed to explain the obtained selectivities.
authors: Leibniz-Institut für Katalyse e.V. an der Universität Rostock, Rostock, Germany.
authors: Sandra
authors: S
authors: Hübner
authors: Haijun
authors: H
authors: Jiao
authors: Dirk
authors: D
authors: Michalik
authors: Helfried
authors: H
authors: Neumann
authors: Stefan
authors: S
authors: Klaus
authors: Dirk
authors: D
authors: Strübing
authors: Anke
authors: A
authors: Spannenberg
authors: Matthias
authors: M
authors: Beller