title: Formulation and characterization of formaldehyde cross-linked degradable starch microspheres containing terbutaline sulfate.
abstract: Preparation of starch microspheres using epichlorohydrin is a time consuming method and requires around 18 hr for cross-linking reaction. To reduce reaction time, terbutaline sulfate (TBS) loaded degradable starch microspheres (DSM) were prepared using formaldehyde as the cross-linking agent. All microspheres were spherical in shape and had a porous, rough surface with a mean particle size of 18-24 microm. Whatever the cross-linking time, it was seen that the release of the TBS was not complete during the release experiments. The influence of enzyme on the degradation of microspheres was moderate. Following intravenous administration, initial uptake of microspheres by the lung was higher than those of other organs.
authors: Faculty of Pharmacy, Hacettepe University, Ankara, Turkey.
authors: Handan
authors: H
authors: Selek
authors: Selma
authors: S
authors: Sahin
authors: H Suheyla
authors: HS
authors: Kas
authors: A Atilla
authors: AA
authors: Hincal
authors: Gilles
authors: G
authors: Ponchel
authors: Meral T
authors: MT
authors: Ercan
authors: Mustafa
authors: M
authors: Sargon
mesh_terms: D000318:Adrenergic beta-Agonists / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D000818:Animals; D019540:Area Under Curve; D001682:Biological Availability; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D003432:Cross-Linking Reagents / Q000737:chemistry*; D004058:Diffusion; D004305:Dose-Response Relationship, Drug; D004339:Drug Compounding / Q000379:methods; D005557:Formaldehyde / Q000737:chemistry*; D005612:Freeze Drying / Q000379:methods; D006207:Half-Life; D007275:Injections, Intravenous; D008168:Lung / Q000378:metabolism; D008297:Male; D051379:Mice; D008855:Microscopy, Electron, Scanning; D010316:Particle Size; D013213:Starch / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D013726:Terbutaline / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D014018:Tissue Distribution
chemical_list: D000318:Adrenergic beta-Agonists; D003432:Cross-Linking Reagents; C083286:degradable starch microspheres; D005557:Formaldehyde; D013213:Starch; D013726:Terbutaline