title: Aurantiomides A-C, quinazoline alkaloids from the sponge-derived fungus Penicillium aurantiogriseum SP0-19.
abstract: Three new quinazoline alkaloids, aurantiomides A (1), B (2), and C (3), along with the known metabolite anacine (4) were isolated from the sponge-derived fungus strain Penicillium aurantiogriseum SP0-19 by bioassay-guided fractionation. Their structures were elucidated by spectroscopic and chemical methods. Their absolute configurations were deduced by comparison of their Cotton effects with anacine (4) and by chemical transformations. Compounds 2 and 3 showed moderate cytotoxicities against HL-60, P388 and BEL-7402, P388 cell lines, respectively.
authors: Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People's Republic of China.
authors: Zhi Hong
authors: ZH
authors: Xin
authors: Yuchun
authors: Y
authors: Fang
authors: Lin
authors: L
authors: Du
authors: Tianjiao
authors: T
authors: Zhu
authors: Lin
authors: L
authors: Duan
authors: Juan
authors: J
authors: Chen
authors: Qian-Qun
authors: QQ
authors: Gu
authors: Wei-Ming
authors: WM
authors: Zhu
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification*; D000818:Animals; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007941:Leukemia P388; D051379:Mice; D015394:Molecular Structure; D010407:Penicillium / Q000737:chemistry*; D011161:Porifera / Q000382:microbiology; D011799:Quinazolines / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D000470:Alkaloids; D011799:Quinazolines; C521029:aurantiomide A; C521030:aurantiomide B; C521031:aurantiomide C