title: Control of Trypanosoma evansi infection is IgM mediated and does not require a type I inflammatory response.
abstract: Very recent reports have documented that Trypanosoma evansi, the etiological agent of the livestock disease "surra," can cause human trypanosomiasis. In contrast to trypanosomes causing human African trypanosomiasis, T. evansi has a wide geographic distribution and host range, yet information about the immunobiological aspects of T. evansi trypanosomiasis is limited. Here, we show that, although T. evansi causes the induction of tumor necrosis factor (TNF), interferon-gamma, and nitric oxide during the early stage of infection, none of these molecules are crucial for parasitemia control and survival of the infected animal. However, TNF and TNF receptor 2 affect the induction of late-stage anemia. Using B cell- and immunoglobulin M (IgM)-deficient mice, we identified IgM as being crucial for parasitemia control and host survival. Collectively, our results show that, compared with other trypanosomes, T. evansi displays a distinct host-parasite interaction profile, give that, despite an infection-associated induction of proinflammatory molecules, only IgM antibodies contribute significantly to parasite control.
authors: Department of Cellular and Molecular Interactions, Vlaams Interuniversitair Instituut voor Biotechnologie, Laboratorium voor Cellulaire en Moleculaire Immunologie, Vrije Universiteit Brussel, Brussels, B-1050, Belgium. tbaral@vub.ac.be
authors: Toya Nath
authors: TN
authors: Baral
authors: Patrick
authors: P
authors: De Baetselier
authors: Frank
authors: F
authors: Brombacher
authors: Stefan
authors: S
authors: Magez
mesh_terms: D000818:Animals; D018929:Cell Culture Techniques; D016207:Cytokines / Q000032:analysis; D004195:Disease Models, Animal; D005260:Female; D007075:Immunoglobulin M / Q000276:immunology*; D007249:Inflammation / Q000276:immunology / Q000469:parasitology; D051379:Mice; D008810:Mice, Inbred C57BL; D018512:Parasitemia / Q000503:physiopathology; D013997:Time Factors; D014345:Trypanosoma; D014352:Trypanosomiasis / Q000276:immunology* / Q000473:pathology; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D016207:Cytokines; D007075:Immunoglobulin M; D014409:Tumor Necrosis Factor-alpha