title: [Complex analysis of prognostic factors in chronic lymphocytic leukemia].
abstract: BACKGROUND
  Many new prognostic factors established in recent years in chronic lymphocytic leukemia. May help predicting survival.
  
  
  OBJECTIVE
  The goal of the present study was to determine the frequency and the correlation of these novel prognostic factors in samples of 419 leukemia patients.
  
  
  METHODS
  The mutation status of the IgH gene was evaluated in 160 cases.
  
  
  RESULTS
  In 62% of cases, non-mutated IgH gene was found, the heavy chain family usage was different in mutated and non-mutated cases. The CD38 expression demonstrated 78% concordance with the mutation status, the ZAP-70 expression failed to show any correlation. Cytogenetic abnormalities were seen in 76% of cases, the most frequent were del(13q) (57%), trisomy 12 (15%), del(11q) (12%) and del(17p) (6%). 95% of cases with del(11q) harbored non-mutated, 74% of cases with del(13q) as the sole anomaly demonstrated mutated IgH genes.
  
  
  CONCLUSIONS
  The parameters analysed are not independent of each other, utilization of them in the clinical routine needs careful planning.
authors: Pécsi Tudományegyetem, Altalános Orvostudományi Kar, Patológiai Intézet, Pécs. bkajtar@pathology.pote.hu
authors: Béla
authors: B
authors: Kajtár
authors: Pál
authors: P
authors: Jáksó
authors: László
authors: L
authors: Kereskai
authors: Agnes
authors: A
authors: Lacza
authors: Gábor
authors: G
authors: Méhes
authors: Mária Anna
authors: MA
authors: Bodnár
authors: J Péter
authors: JP
authors: Dombi
authors: Zoltán
authors: Z
authors: Gasztonyi
authors: Miklós
authors: M
authors: Egyed
authors: János László
authors: JL
authors: Iványi
authors: Gábor
authors: G
authors: Kovács
authors: Eva
authors: E
authors: Marton
authors: Aranka
authors: A
authors: Palaczki
authors: Sándor
authors: S
authors: Petz
authors: Péter
authors: P
authors: Tóth
authors: Erzsébet
authors: E
authors: Sziládi
authors: Hajna
authors: H
authors: Losonczy
authors: László
authors: L
authors: Pajor
mesh_terms: D051997:ADP-ribosyl Cyclase 1 / Q000378:metabolism; D000368:Aged; D002880:Chromosomes, Human, Pair 11; D002882:Chromosomes, Human, Pair 13; D002886:Chromosomes, Human, Pair 17; D004273:DNA, Neoplasm / Q000032:analysis; D005260:Female; D005434:Flow Cytometry; D017353:Gene Deletion; D015321:Gene Rearrangement; D050438:Genes, Immunoglobulin Heavy Chain / Q000235:genetics*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000175:diagnosis* / Q000235:genetics* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009154:Mutation; D011237:Predictive Value of Tests; D011379:Prognosis; D017422:Sequence Analysis, DNA; D016019:Survival Analysis; D014314:Trisomy; D051746:ZAP-70 Protein-Tyrosine Kinase / Q000378:metabolism
chemical_list: D004273:DNA, Neoplasm; D051746:ZAP-70 Protein-Tyrosine Kinase; D051997:ADP-ribosyl Cyclase 1