title: Analysis of the myocardial metabolism by microdialysis during open beating heart surgery.
abstract: OBJECTIVE
  Microdialysis allows the in vivo biochemical analysis of interstitial fluids. Our aim was to reveal in vivo reliable data of the myocardium during open beating heart surgery.
  
  
  METHODS
  In ten patients undergoing routine beating coronary artery bypass grafting a microdialysis catheter was inserted into the left ventricle. Measurements were performed up to 45 min after anastomosis. Data were retrospectively compared with standard on-pump procedures.
  
  
  RESULTS
  The myocardial lactate remained stable during anastomosis, followed by a significant decrease of lactate after revascularisation. Myocardial glucose levels showed a slight decrease, followed by a significant increase after revascularisation. Myocardial purines showed a slight increase during anastomosis, followed by a sharp decrease during reperfusion period.
  
  
  CONCLUSIONS
  In contrast to on-pump procedures myocardial lactate and purines showed less increasing trend during the ischemic period, while myocardial glucose remained stable as a sign of preserved tissue blood flow. Myocardial microdialysis showed different values compared to the elective on-pump CABG and previous animal studies. This technique allows bedside monitoring of biochemical changes, suggesting its possible role as a clinical monitoring tool.
authors: Department of Cardiac Surgery, Schüchtermann-Klinik Bad Rothenfelde, Germany. jochen.poeling@freenet.de
authors: Jochen
authors: J
authors: Pöling
authors: Alexander
authors: A
authors: Leptien
authors: Stephan
authors: S
authors: Klaus
authors: Wolfgang
authors: W
authors: Rees
authors: Ernst
authors: E
authors: Kraatz
authors: Karsten
authors: K
authors: Wiebe
authors: Ludger
authors: L
authors: Bahlmann
mesh_terms: D000368:Aged; D006328:Cardiac Catheterization; D002318:Cardiovascular Diseases / Q000601:surgery*; D047549:Coronary Artery Bypass, Off-Pump; D005260:Female; D006801:Humans; D019344:Lactic Acid / Q000378:metabolism*; D008297:Male; D017551:Microdialysis; D008875:Middle Aged; D009204:Myocardial Revascularization / Q000379:methods; D009206:Myocardium / Q000378:metabolism*; D019289:Pyruvic Acid / Q000378:metabolism; D012189:Retrospective Studies; D013997:Time Factors
chemical_list: D019344:Lactic Acid; D019289:Pyruvic Acid