Lymphohistiocytoid variant of malignant mesothelioma of the pleura: a series of 22 cases.
The lymphohistiocytoid variant of diffuse malignant mesothelioma is rare with very few cases described in the literature. It is characterized by mesothelial cells with a histiocytelike appearance and an associated dense lymphoid infiltrate. We studied clinicopathologic features and immunohistochemical patterns of a series of 22 cases. The histiocytelike cells had a mesothelial immunophenotype: AE1/AE3 (100%), calretinin (100%), CK5/6 (46%), and EMA (52%). The prominent lymphoid component showed a cytotoxic T-cell immunophenotype. Prognosis was similar to that of a large series of epithelioid diffuse malignant mesotheliomas. Formely, it was classified within the sarcomatoid type. We suggest that it should be reclassified as an epithelioid variant because of its similar behavioural characteristics. There was no evidence of Epstein-Barr virus-related infection.
Galateau-Sallé
Francoise
F
Mesopath Group, ERI 3 Inserm, CHU Caen, Caen, France. galateausalle-f@chu-caen.fr
Attanoos
Richard
R
Gibbs
Allen R
AR
Burke
Louise
L
Astoul
Philippe
P
Rolland
Patrick
P
Ilg
Anabelle Gilg Soit
AG
Pairon
Jean Claude
JC
Brochard
Patrick
P
Begueret
Hugues
H
Vignaud
Jean Michel
JM
Kerr
Keith
K
Launoy
Guy
G
Imbernon
Ellen
E
Goldberg
Marcel
M
D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism; D004848:Epithelium / Q000378:metabolism / Q000473:pathology; D005260:Female; D006644:Histiocytes / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D008297:Male; D008654:Mesothelioma / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D008875:Middle Aged; D010997:Pleural Neoplasms / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D011379:Prognosis; D015996:Survival Rate; D013602:T-Lymphocytes, Cytotoxic / Q000378:metabolism / Q000473:pathology*
D014408:Biomarkers, Tumor