Foxp3 in control of the regulatory T cell lineage.
Foxp3, an X chromosome-encoded forkhead transcription factor family member, is indispensable for the differentiation of regulatory T cells. These cells have a vital role in preventing autoimmunity and pathology inflicted by uncontrolled immune responses to infections. Deficiency or mutation in Foxp3 in humans and mice leads to an early onset, highly aggressive and fatal autoimmune disease affecting various tissues. Here, we review recent advances in our understanding of the Foxp3-dependent molecular and functional program and the role of Foxp3 in regulatory T cell biology.
Zheng
Ye
Y
Department of Immunology, University of Washington, Seattle, Washington 98195, USA.
Rudensky
Alexander Y
AY
D000818:Animals; D019070:Cell Lineage / Q000276:immunology*; D051858:Forkhead Transcription Factors / Q000502:physiology*; D006801:Humans; D013601:T-Lymphocytes / Q000166:cytology* / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000166:cytology / Q000276:immunology* / Q000378:metabolism
C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors; C498833:Foxp3 protein, mouse