title: Does the pre-ischaemic administration of sevoflurane reduce myocardial stunning? A porcine experimental model.
abstract: BACKGROUND
  In a porcine model, the cardioprotective effect of sevoflurane was studied with regard to the preservation of myocardial contractility (myocardial stunning) after a myocardial ischaemic insult.
  
  
  METHODS
  Twenty-seven pigs were randomized to receive either a dual 4% sevoflurane inhalation period as a supplement to pentobarbital anaesthesia or pentobarbital anaesthesia only before a 15-min ischaemic insult on the left anterior descending coronary artery. The ischaemic period was followed by 180 min of reperfusion. Myocardial contractility was assessed by myocardial sonomicrometry.
  
  
  RESULTS
  A significant difference was found between the sevoflurane group and the control group at 5 min of reperfusion. However, subsequently, there was no overall difference between the two groups.
  
  
  CONCLUSIONS
  Sevoflurane administered as a pre-ischaemic bolus does not provide long-term improvement of the myocardial contractility. However, it can be speculated that sevoflurane may induce an early improvement in contractility.
authors: Department of Cardiothoracic and Vascular Research and Institute of Clinical Medicine, Aarhus University Hospital, Skejby Sygehus, Brendstrupgaardsvej 100, DK-8200 Aarhus N, Denmark.
authors: S
authors: S
authors: Aagaard
authors: J R
authors: JR
authors: Larsen
authors: J S
authors: JS
authors: Berg
authors: E
authors: E
authors: Sloth
authors: J M
authors: JM
authors: Hasenkam
mesh_terms: D018685:Anesthetics, Inhalation / Q000008:administration & dosage*; D000818:Animals; D005260:Female; D006993:Hypnotics and Sedatives / Q000008:administration & dosage; D008738:Methyl Ethers / Q000008:administration & dosage*; D023421:Models, Animal; D008991:Monitoring, Physiologic; D009200:Myocardial Contraction / Q000187:drug effects*; D017682:Myocardial Stunning / Q000517:prevention & control*; D010424:Pentobarbital / Q000008:administration & dosage; D011897:Random Allocation; D000077149:Sevoflurane; D034421:Sus scrofa; D013997:Time Factors
chemical_list: D018685:Anesthetics, Inhalation; D006993:Hypnotics and Sedatives; D008738:Methyl Ethers; D000077149:Sevoflurane; D010424:Pentobarbital