Disposition and clearance of tungsten after single-dose oral and intravenous exposure in rodents.
Tungsten (W) has been nominated for study to the National Toxicology Program (NTP) because of reported associations between concentrations of W in drinking water and childhood leukemia. The disposition of W (administered as sodium tungstate dihydrate in water) in plasma, liver, kidneys, uterus, femur, and intestine of rodents (Sprague-Dawley rats and C57BL/6N mice) was characterized after exposures by oral gavage (1, 10, or 100 mg/kg) or intravenous (1 mg/kg) administration. Each tissue (or plasma) was collected and analyzed by inductively coupled plasma mass spectrometry at 1, 2, 4, or 24 h after dose administration. W was observed in plasma and all tissues after both gavage and i.v. administration. In rats, concentrations in plasma and most tissues peaked at 4 h. In mice, concentrations in plasma and most tissues peaked at 1 h. Although the amount of W in each matrix decreased significantly by 24 h, there was W remaining in several tissues, especially at the higher doses.
McDonald
Jacob D
JD
Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87108, USA. jmcdonal@lrri.org
Weber
Waylon M
WM
Marr
Rena
R
Kracko
Dean
D
Khain
Hnin
H
Arimoto
Richard
R
D000284:Administration, Oral; D000818:Animals; D005260:Female; D006207:Half-Life; D007275:Injections, Intravenous; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors; D014018:Tissue Distribution; D014414:Tungsten / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000633:toxicity*
D014414:Tungsten