Advanced criteria for clinicopathological diagnosis of food protein-induced proctocolitis.
The clinicopathological findings in previous studies concerning food protein-induced proctocolitis (FPIPC) are quite diverse in terms of results and conclusions. The aim of this study was to suggest advanced clinicopathological diagnostic criteria that facilitate the early confirmation of FPIPC. Data of 38 FPIPC patients, who had received sigmoidoscopy and biopsy, was analyzed. Microscopic findings were compared with observations of previous studies. Feeding at onset of bleeding was exclusively breast-fed (94.7%) and formula-fed or mixed-fed (5.3%). Endoscopic abnormalities were observed in all patients; nodular hyperplasias with circumscribed and/or central pit-like erosions in 94.7% and erythema in 5.3%. Histopathological findings were; lymphoid aggregates in 94.7%, eosinophils in lamina propria of >or=60 cells/10 HPF in 97.4% and of >20 cells/HPF in 63.2%, epithelial or muscularis mucosa eosinophil infiltration in 97.4%, and crypt abscess in 2.6%. The majority of FPIPC patients are exclusively breast-fed and nodular hyperplasias with erosions may be a disease specific endoscopic finding. Histologic diagnosis of FPIPC is compatible with eosinophils in the lamina propria of >or=60 cells/10 high power fields; however, >20 cells/HPF is not an appropriate diagnostic criterion.
Hwang
Jin-Bok
JB
Department of Pediatrics, Dongsan Medical Center, Keimyung University School of Medicine, 194 Dongsan-dong, Jung-gu, Daegu, Korea. pedgi@kmu.ac.kr
Park
Moon Ho
MH
Kang
Yu Na
YN
Kim
Sang Pyo
SP
Suh
Seong-Il
SI
Kam
Sin
S
D001942:Breast Feeding / Q000009:adverse effects*; D003937:Diagnosis, Differential; D004044:Dietary Proteins / Q000009:adverse effects*; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000175:diagnosis* / Q000209:etiology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D011350:Proctocolitis / Q000175:diagnosis* / Q000209:etiology*; D012002:Rectal Diseases / Q000175:diagnosis* / Q000209:etiology; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
D004044:Dietary Proteins