title: Effect of interleukin-10 on tissue damage caused by organophosphate poisoning.
abstract: Organophosphate poisoning is a common cause of severe morbidity and mortality among patients admitted to emergency departments. Tissue damages as a consequence of organophosphate poisoning are frequently reported, but preventing this potentially severe complication has not been the subject of much research. We tested whether interleukin-10, a cytoprotective agent, could prevent or diminish pathological signs of tissue damages caused by organophosphate poisoning. Thirty rats were divided into three equal groups (n = 10). Group 1 (sham) did not receive any agent during the experiment. Group 2 (control) received 0.8 g/kg of fenthion intraperitoneally, followed by 6 ml/kg of intraperitoneal normal saline 30 min and 3 hr later. Group 3 (treatment) received 0.8 g/kg of fenthion intraperitoneally, followed by 2 microg/kg of interleukin-10 intraperitoneally 30 min and 3 hr later. All rats were killed under anaesthesia after 6 hr and tissue samples were obtained from liver, kidneys and lungs. Even organophosphate poisonings do not cause significant clinical problems; several degrees of damages could be observed in liver, kidneys and lungs. These damages could be reduced by interleukin-10 treatment.
authors: Department of Emergency Medicine, Kocatepe University Medical Faculty, Afyon, Turkey.
authors: Yusuf
authors: Y
authors: Yurumez
authors: Ibrahim
authors: I
authors: Ikizceli
authors: Erdogan Mutevelli
authors: EM
authors: Sozuer
authors: Isin
authors: I
authors: Soyuer
authors: Yucel
authors: Y
authors: Yavuz
authors: Levent
authors: L
authors: Avsarogullari
authors: Polat
authors: P
authors: Durukan
mesh_terms: D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000473:pathology / Q000517:prevention & control*; D002800:Cholinesterase Inhibitors / Q000506:poisoning*; D004336:Drug Antagonism; D004359:Drug Therapy, Combination; D005260:Female; D005284:Fenthion / Q000506:poisoning*; D007274:Injections, Intraperitoneal; D016753:Interleukin-10 / Q000494:pharmacology*; D007674:Kidney Diseases / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D008171:Lung Diseases / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D002800:Cholinesterase Inhibitors; D016753:Interleukin-10; D005284:Fenthion