Treatment failure in a case of extensively drug-resistant tuberculosis associated with selection of a GyrB mutant causing fluoroquinolone resistance.
Veziris
N
N
Laboratoire de Bactériologie, Faculté de Médecine Pierre et Marie Curie, Université Paris 6 et Centre National de Référence de la Résistance des Mycobactéries et de la Résistance aux Antituberculeux, Groupe Hospitalier Pitié-Salpêtrière, Paris, France.
Martin
C
C
Brossier
F
F
Bonnaud
F
F
Denis
F
F
Aubry
A
A
D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001426:Bacterial Proteins / Q000235:genetics; D027081:DNA Gyrase / Q000235:genetics*; D024901:Drug Resistance, Multiple, Bacterial; D017809:Fatal Outcome; D024841:Fluoroquinolones / Q000627:therapeutic use*; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D009154:Mutation; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D011859:Radiography; D017211:Treatment Failure; D018088:Tuberculosis, Multidrug-Resistant / Q000188:drug therapy* / Q000382:microbiology*
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D024841:Fluoroquinolones; D027081:DNA Gyrase