Cell migration rate on poly(epsilon-caprolactone)/poly(ethylene glycol) diblock copolymers and correlation with the material sliding angle.
The nanostructure of a biomaterial surface has strong influence on cell behavior. The migration of cells on nanostructured surfaces, however, has not been investigated so far. In this study, we used PCL/PEG diblock copolymers as model surfaces to examine the effect of nanoislands on migration of different cells, including fibroblasts and endothelial cells. The water sliding angle of the substrates was measured. The cell migration rate was examined under a real-time optical microscope. It was found that a greater cell migration rate correlated with the smaller sliding angle of the substrate.
Hsu
Shan-hui
SH
Center of Tissue Engineering and Stem Cells Research, National Chung Hsing University, Taichung, Taiwan, Republic of China. shhsu@nchu.edu.tw
Tang
Cheng-Ming
CM
Chiu
Jeng-Jiann
JJ
Liao
Tien-Chi
TC
Lin
Chu-Chieh
CC
Iwata
Hiroo
H
D000818:Animals; D002339:Carotid Arteries / Q000166:cytology / Q000502:physiology*; D002417:Cattle; D002465:Cell Movement / Q000502:physiology*; D002478:Cells, Cultured; D020099:Coated Materials, Biocompatible / Q000737:chemistry; D042783:Endothelial Cells / Q000166:cytology / Q000502:physiology*; D005026:Ethylene Glycols / Q000737:chemistry; D005347:Fibroblasts / Q000166:cytology / Q000502:physiology*; D006801:Humans; D011091:Polyesters / Q000737:chemistry
D020099:Coated Materials, Biocompatible; D005026:Ethylene Glycols; D011091:Polyesters; C476300:poly(epsilon-caprolactone)-b-poly(ethylene glycol)