title: Involvement of protein synthesis in the reconsolidation of memory at different time points after formation of conditioned reflex freezing in mice.
abstract: The aim of the present work was to study the involvement of protein synthesis in the reconsolidation of memory at different periods of time after training. In mice trained in a conditioned reflex freezing model, memory was reactivated by a reminder combined with administration of the protein synthesis inhibitor cycloheximide. The results showed that suppression of protein synthesis on reactivation of memory 3, 6, and 24 h and 14 and 30 days after training impaired acquired conditioned reflex freezing. These data provide evidence that memories retrieved by a reminder require protein-dependent reorganization at both short (3-6 h) and long (14-30 days) periods after training.
authors: P. K. Anokhin Research Institute of Normal Physiology, Russian Academy of Medical Sciences, Moscow, Russia.
authors: E V
authors: EV
authors: Murav'eva
authors: K V
authors: KV
authors: Anokhin
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001522:Behavior, Animal; D003214:Conditioning, Classical / Q000187:drug effects / Q000502:physiology*; D003513:Cycloheximide / Q000494:pharmacology; D046352:Freezing Reaction, Cataleptic / Q000187:drug effects / Q000502:physiology*; D008297:Male; D008568:Memory / Q000187:drug effects / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D011500:Protein Synthesis Inhibitors / Q000494:pharmacology; D013997:Time Factors
chemical_list: D011500:Protein Synthesis Inhibitors; D003513:Cycloheximide