[Bacterial ribulose monophosphate pathway and formaldehyde assimilation].
Ribulose monophosphate pathway (RuMP), which was originally found in methylotrophic bacteria, is now recognized as a metabolic pathway widespread in most bacteria and involved in formaldehyde assimilation and detoxification. 3-Hexulose-6-phosphate synthase (HPS) and 6-phospho-3-hexuloisomerase (PHI) are the key enzymes of this pathway. This review describes the physiological significance of RuMP pathway derived from a variety of bacteria, the organizations and expressional regulations of HPS and PHI genes and the perspectives for applications of the two genes.
Song
Zhong-bang
ZB
Biotechnology Research Center, Kunming University of Science and Technology, Kunming 650224, China. zbsoon@yahoo.com.cn
Chen
Li-mei
LM
Li
Kun-zhi
KZ
Pan
Zheng-Bo
ZB
D000446:Aldehyde-Lyases / Q000235:genetics; D001419:Bacteria / Q000378:metabolism*; D005557:Formaldehyde / Q000378:metabolism*; D005956:Glucose-6-Phosphate Isomerase / Q000235:genetics; D012274:Ribulosephosphates / Q000378:metabolism*
D012274:Ribulosephosphates; D005557:Formaldehyde; D000446:Aldehyde-Lyases; C021355:hexose phosphate synthetase; D005956:Glucose-6-Phosphate Isomerase