[Modulation of programmed death of the peripheral blood lymphocytes under chronic virus infection].
We investigated programmed death of lymphocytes in patients with chronic infections--tick-borne encephalitis, hepatitis B and C. It has been shown that the character of disorders in realization of lymphocyte apoptosis depends on molecular features of the infectious agent. Apoptotic death of lymphocytes was elevated after incubation in vitro with dexamethazone, etopozide and in medium without serum. Receptor-dependent and mitochondrial paths of apoptotic signal conduction are preferentially modulated under chronic virus persistence.
Zhukova
O B
OB
Riazantseva
N V
NV
Novitskiĭ
V V
VV
Radzivil
T T
TT
Litvinova
L S
LS
Chasovskikh
N Iu
NIu
D017209:Apoptosis; D002478:Cells, Cultured; D002908:Chronic Disease; D003907:Dexamethasone / Q000494:pharmacology; D004675:Encephalitis, Tick-Borne / Q000503:physiopathology*; D005047:Etoposide / Q000494:pharmacology; D019694:Hepatitis B, Chronic / Q000503:physiopathology*; D019698:Hepatitis C, Chronic / Q000503:physiopathology*; D006801:Humans; D007963:Leukocytes, Mononuclear; D008214:Lymphocytes / Q000473:pathology*; D008564:Membrane Potentials; D008928:Mitochondria / Q000502:physiology; D018124:Receptors, Tumor Necrosis Factor / Q000378:metabolism; D019014:fas Receptor / Q000378:metabolism
D018124:Receptors, Tumor Necrosis Factor; D019014:fas Receptor; D005047:Etoposide; D003907:Dexamethasone