[A clinical analysis of intrahepatic cholestasis of pregnancy in 1241 cases].
OBJECTIVE
To study the clinical features and diagnosis of intrahepatic cholestasis of pregnancy (ICP).


METHODS
During the last 10 years 1241 cases of ICP stayed in our hospital. Their clinical data were retrospectively reviewed.


RESULTS
5.2% of all the maternity patients had ICP. It occurred more in winter and 3.5% of ICP occurred in multiple pregnancies. The recurrence rate of ICP was 30.2%. On the average, it occurred at gestational week 32.6. Skin pruritus was the characteristic manifestation and the presenting symptom in 1201 patients (96.8%). The other presenting features included elevated serum ALT and AST (2.3%), jaundice (8 patients), diarrhea (3 patients), deep yellow urine (2 patients) and right upper abdominal pain (1 patient). The serum transaminases levels were elevated, of which 60% were between 50-200 IU/L. Serum total bile acid (TBA) levels were elevated in 82.4% of the patients and bilirubin levels in 33.4%. The elevated bilirubin levels were 30 to 90 micromol/L in 85% of those patients with this condition, and it was never higher than 170 micromol/L.


CONCLUSIONS
The basic diagnostic points of ICP are pruritus and abnormal liver function characterized by increased transaminases and TBA. Therefore paying attention to typical pruritus and other atypical features such as elevated serum transaminases, jaundice, diarrhea, deep yellow urine and right upper abdominal pain during antenatal care is important for an early diagnosis of ICP.
Wang
Xiao-dong
XD
Department of Obstetrics and Gynecology, West China Second Hospital of Sichuan University, Chengdu 610041, China.
Yao
Qiang
Q
Peng
Bing
B
Zhang
Li
L
Ai
Ying
Y
Ying
Ai-yun
AY
Liu
Xing-hui
XH
Liu
Shu-yun
SY
D000328:Adult; D002780:Cholestasis, Intrahepatic; D005260:Female; D006801:Humans; D011247:Pregnancy; D011248:Pregnancy Complications; D012189:Retrospective Studies; D055815:Young Adult