title: Loss of heterozygosity studies in extracranial metastatic meningiomas.
abstract: Although most meningiomas are slow-growing tumours associated with favourable prognosis, they often present local recurrence after surgical treatment; by contrast, extracranial metastatic meningiomas are rare, occurring in less than 1% of the cases. Risk factors for distal spread remain largely unknown. We report three cases with lung or bone metastases from intracranial recurrent meningiomas. Loss of heterozygosity (LOH) analysis on 1p, 9p, 10q, 14q, and 22q was conducted in available primary, recurrent and metastatic lesions, showing the same LOH pattern in the distal metastases and in the intracranial meningioma. LOH at 1p, 14q and 9p, known to be associated with increased aggressiveness, were found. The results highlight the potential clinical relevance of integrating histopathological studies with molecular genetic analysis in the follow-up of patients with different types of meningiomas.
authors: Department of Experimental Neurology and Diagnostics, Fondazione IRCCS Istituto Neurologico Besta, Milano, Italy.
authors: Caroline Regna
authors: CR
authors: Gladin
authors: Ettore
authors: E
authors: Salsano
authors: Francesca
authors: F
authors: Menghi
authors: Marina
authors: M
authors: Grisoli
authors: Francesco
authors: F
authors: Ghielmetti
authors: Ida
authors: I
authors: Milanesi
authors: Bianca
authors: B
authors: Pollo
authors: Stefano
authors: S
authors: Brock
authors: Alberto
authors: A
authors: Cusin
authors: Ludovico
authors: L
authors: Minati
authors: Gaetano
authors: G
authors: Finocchiaro
authors: Maria Grazia
authors: MG
authors: Bruzzone
mesh_terms: D000328:Adult; D001859:Bone Neoplasms / Q000235:genetics / Q000556:secondary; D001921:Brain / Q000473:pathology; D002875:Chromosomes / Q000235:genetics; D004273:DNA, Neoplasm / Q000235:genetics; D006801:Humans; D019656:Loss of Heterozygosity / Q000502:physiology*; D008175:Lung Neoplasms / Q000235:genetics / Q000556:secondary; D008297:Male; D008579:Meningioma / Q000235:genetics* / Q000473:pathology / Q000556:secondary*; D008875:Middle Aged; D009362:Neoplasm Metastasis; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014057:Tomography, X-Ray Computed
chemical_list: D004273:DNA, Neoplasm