Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia.
We identified a duplication of the MYB oncogene in 8.4% of individuals with T cell acute lymphoblastic leukemia (T-ALL) and in five T-ALL cell lines. The duplication is associated with a threefold increase in MYB expression, and knockdown of MYB expression initiates T cell differentiation. Our results identify duplication of MYB as an oncogenic event and suggest that MYB could be a therapeutic target in human T-ALL.
Lahortiga
Idoya
I
Human Genome Laboratory, Department of Molecular and Developmental Genetics, Vlaams Instituut voor Biotechnologie (VIB), Leuven, Belgium.
De Keersmaecker
Kim
K
Van Vlierberghe
Pieter
P
Graux
Carlos
C
Cauwelier
Barbara
B
Lambert
Frederic
F
Mentens
Nicole
N
Beverloo
H Berna
HB
Pieters
Rob
R
Speleman
Frank
F
Odero
Maria D
MD
Bauters
Marijke
M
Froyen
Guy
G
Marynen
Peter
P
Vandenberghe
Peter
P
Wlodarska
Iwona
I
Meijerink
Jules P P
JP
Cools
Jan
J
D002454:Cell Differentiation / Q000235:genetics* / Q000276:immunology; D045744:Cell Line, Tumor; D022201:Chromosomes, Artificial / Q000235:genetics; D005434:Flow Cytometry; D018628:Gene Dosage; D020440:Gene Duplication; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics; D020570:Genes, myb / Q000235:genetics*; D005820:Genetic Testing; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000235:genetics*; D009154:Mutation / Q000235:genetics; D009693:Nucleic Acid Hybridization / Q000235:genetics; D034741:RNA, Small Interfering / Q000235:genetics; D018709:Statistics, Nonparametric; D013601:T-Lymphocytes / Q000473:pathology*
D034741:RNA, Small Interfering