title: Association between Chlamydia trachomatis and abnormal uterine bleeding.
abstract: OBJECTIVE
  The purpose was to identify distinct inflammatory markers in endometrial tissues of women with abnormal uterine bleeding (AUB) and Chlamydia trachomatis infection.
  
  
  METHODS
  Archived endometrial specimens from 92 randomly selected premenopausal women with AUB were examined for C. trachomatis using the species-specific monoclonal antibody against major outer membrane protein (MOMP) and for histopathology associated with inflammation. Statistical analyses included single and multiple logistic regression. Diagnostic accuracy was summarized using receiver operating characteristic (ROC) curves.
  
  
  RESULTS
  Chlamydia trachomatis was detected in 44 (48%) of 92 AUB specimens. There were statistically significant correlations of positive MOMP with higher counts of plasma cells (P < 0.01), macrophages (P < 0.0001), and lymphocytic foci (P = 0.01). The ROC curve for macrophages was the strongest predictor (area under the curve = 0.82) for C. trachomatis.
  
  
  CONCLUSIONS
  The prevalence of C. trachomatis in women with AUB is under-estimated. Macrophages appear to be a strong marker for the presence of C. trachomatis in the endometrium.
authors: Department of OB/GYN, Hill Hospital, New York, NY, USA.
authors: Miklos
authors: M
authors: Toth
authors: Dorothy L
authors: DL
authors: Patton
authors: Benjamin
authors: B
authors: Esquenazi
authors: Maria
authors: M
authors: Shevchuk
authors: Howard
authors: H
authors: Thaler
authors: Michael
authors: M
authors: Divon
mesh_terms: D000293:Adolescent; D000328:Adult; D000911:Antibodies, Monoclonal; D001425:Bacterial Outer Membrane Proteins / Q000276:immunology; D002452:Cell Count; D002690:Chlamydia Infections / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology / Q000382:microbiology / Q000473:pathology; D002692:Chlamydia trachomatis / Q000276:immunology / Q000302:isolation & purification*; D004716:Endometritis / Q000382:microbiology / Q000473:pathology*; D004717:Endometrium / Q000382:microbiology / Q000473:pathology*; D005260:Female; D006801:Humans; D016015:Logistic Models; D008214:Lymphocytes / Q000473:pathology; D008264:Macrophages / Q000473:pathology*; D008796:Metrorrhagia / Q000382:microbiology / Q000473:pathology*; D008875:Middle Aged; D010950:Plasma Cells / Q000473:pathology; D011237:Predictive Value of Tests; D017697:Premenopause; D015995:Prevalence; D012372:ROC Curve; D012189:Retrospective Studies; D012680:Sensitivity and Specificity
chemical_list: D000911:Antibodies, Monoclonal; D001425:Bacterial Outer Membrane Proteins