title: Concomitant presentation of acute myeloid leukemia with T-cell large granular lymphocytic leukemia.
abstract: T-cell large granular lymphocyte leukemia (T-LGL) also known as T-cell chronic lymphocytic leukemia is rare and comprises a small minority of all small lymphocytic leukemias. The concomitant presentation of T-LGL with acute myeloid leukemia (AML) has not been previously reported. We present an elderly gentleman with concomitant T-LGL and AML (non-M3) diagnosed by a combination of morphologic evaluation, immunophenotyping by flow cytometry, and T-cell gene rearrangement studies. The patient was managed with combination AML chemotherapy. He remains alive and well seven months after initial diagnosis. A brief review of literature is also presented.
authors: Department of Hematology and Oncology, Heartland Regional Medical Center, St Joseph, Missouri, USA. drmalani@yahoo.com
authors: Ashok Kumar
authors: AK
authors: Malani
authors: Chakshu
authors: C
authors: Gupta
authors: Rajgopal
authors: R
authors: Rangineni
authors: Jaswinder
authors: J
authors: Singh
authors: Hussam
authors: H
authors: Ammar
mesh_terms: D000208:Acute Disease; D000369:Aged, 80 and over; D015703:Antigens, CD / Q000032:analysis; D005434:Flow Cytometry; D006801:Humans; D007951:Leukemia, Myeloid / Q000150:complications / Q000175:diagnosis*; D015461:Leukemia, Prolymphocytic, T-Cell / Q000175:diagnosis*; D008297:Male
chemical_list: D015703:Antigens, CD