title: Trigger finger as an initial manifestation of familial amyloid polyneuropathy in a patient with Ile107Val TTR.
abstract: We describe a Japanese family with transthyretin Val107-related familial amyloid polyneuropathy (FAP). The clinical features were high-aged onset, sensorimotor polyneuropathy, carpal tunnel syndrome (CTS) and trigger finger. In addition, the proband showed cardiac conduction block and amyloid deposition in the sural nerve and dermis. Trigger finger may be a so far unknown clinical manifestation of Val107 FAP due to amyloid deposition in the connective tissue like CTS.
authors: Department of Neurology, Tokyo Metropolitan Neurological Hospital. ukyo@pop06.odn.ne.jp
authors: Kyotaro
authors: K
authors: Uotani
authors: Akihiro
authors: A
authors: Kawata
authors: Masahiro
authors: M
authors: Nagao
authors: Toshio
authors: T
authors: Mizutani
authors: Hideaki
authors: H
authors: Hayashi
mesh_terms: D017668:Age of Onset; D000368:Aged; D019943:Amino Acid Substitution / Q000235:genetics*; D028227:Amyloid Neuropathies, Familial / Q000175:diagnosis / Q000235:genetics*; D002349:Carpal Tunnel Syndrome / Q000175:diagnosis / Q000235:genetics; D005260:Female; D006801:Humans; D007532:Isoleucine / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011228:Prealbumin / Q000235:genetics*; D052582:Trigger Finger Disorder / Q000175:diagnosis / Q000235:genetics*; D014633:Valine / Q000235:genetics*
chemical_list: D011228:Prealbumin; D007532:Isoleucine; D014633:Valine