title: Quantifying the degree of disorder in micronized salbutamol sulfate using moisture sorption analysis.
abstract: Salbutamol sulfate is often micronized for use in dry powder inhalers. Therefore, it is of high interest to quantify the amorphous amount. It was investigated whether moisture sorption is able to measure the amorphous content of salbutamol sulfate. Different mixtures of amorphous and crystalline salbutamol sulfate were analyzed by moisture sorption. The amorphous material was obtained by spray drying. The measurement results were used to plot a calibration curve, which was used to quantify the amorphous amount in micronized salbutamol sulfate.
authors: Institut fuer Pharmazeutische Technologie und Biopharmazie, Heinrich-Heine-Universitaet Duesseldorf, Universitaetsstrasse 1, Duesseldorf, Germany.
authors: Matthias
authors: M
authors: Gorny
authors: Markus
authors: M
authors: Jakobs
authors: Viktoriya
authors: V
authors: Mykhaylova
authors: Nora Anne
authors: NA
authors: Urbanetz
mesh_terms: D000420:Albuterol / Q000737:chemistry*; D001993:Bronchodilator Agents / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning / Q000379:methods*; D003460:Crystallization; D006813:Humidity; D014867:Water / Q000737:chemistry*
chemical_list: D001993:Bronchodilator Agents; D014867:Water; D000420:Albuterol