Determination of the enantiomeric excess of chiral carboxylic acids by 31P NMR with phosphorylated derivatizing agents from C2-symmetrical diamines containing the (S)-alpha-phenylethyl group.
The use of P(III) and P(V) organophosphorus derivatizing agents prepared from C(2) symmetrical (1R,2R)- and (1S,2S)-trans-N,N'-bis-[(S)-alpha-phenylethyl]-cyclohexane-1,2-diamines 1 and 2, as well as (1R,2R)- and (1S,2S)-trans-N,N'-bis-[(S)-alpha-phenylethyl]-4-cyclohexene-1,2-diamines 3 and 4 for the determination of enantiomeric composition of chiral carboxylic acids by (31)P NMR, is described.
Mastranzo
Virginia M
VM
Universidad de las Américas Puebla, Departamento de Ciencias Químico-Biológicas, Santa Catarina Mártir s/n, Cholula, Puebla 72820, México.
Quintero
Leticia
L
de Parrodi
Cecilia Anaya
CA
D002264:Carboxylic Acids / Q000737:chemistry*; D002623:Chemistry Techniques, Analytical / Q000379:methods*; D003959:Diamines / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008956:Models, Chemical; D009943:Organophosphorus Compounds / Q000737:chemistry; D010759:Phosphorus Isotopes / Q000737:chemistry*; D010766:Phosphorylation; D015203:Reproducibility of Results; D013237:Stereoisomerism
D002264:Carboxylic Acids; D003959:Diamines; D009943:Organophosphorus Compounds; D010759:Phosphorus Isotopes