title: Effect of monosodium glutamate on oxidative stress and apoptosis in rat thymus.
abstract: It has been demonstrated that administration of high concentrations of monosodium glutamate (MSG), induce oxidative stress in different organs, but not in thymus. In the present study we examined the role of oxidative stress in MSG-induced thymocyte apoptosis. MSG was administrated intraperitoneally (4 mg/g of body weight) for six consecutive days. Animals were sacrificed at 1st, 7th, and 15th day after last MSG dose. MSG administration to animals significantly increased apoptotic rate of thymocytes (P < 0.01), together with significant increase of malondialdehyde (MDA) level (P < 0.001) and xanthine oxidase (XO) activity (P < 0.01), in time dependent manner. Catalase activity, during examination period, was significantly decreased (0 < 0.01). Obtained results showed that MSG treatment induced oxidative stress in thymus, which may have an important role in thymocyte apoptosis induced by MSG.
authors: Institute of Physiology, Medical Faculty University of Nis, Bulevar dr Zorana Djindjica, Nis, Serbia. vojapav@yahoo.com
authors: Voja
authors: V
authors: Pavlovic
authors: Dusica
authors: D
authors: Pavlovic
authors: Gordana
authors: G
authors: Kocic
authors: Dusan
authors: D
authors: Sokolovic
authors: Tatjana
authors: T
authors: Jevtovic-Stoimenov
authors: Snezana
authors: S
authors: Cekic
authors: Dragana
authors: D
authors: Velickovic
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D049109:Cell Proliferation / Q000187:drug effects*; D002478:Cells, Cultured; D005503:Food Additives / Q000494:pharmacology*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D012970:Sodium Glutamate / Q000494:pharmacology*; D013950:Thymus Gland / Q000187:drug effects* / Q000378:metabolism; D014969:Xanthine Oxidase / Q000378:metabolism
chemical_list: D005503:Food Additives; D008315:Malondialdehyde; D014969:Xanthine Oxidase; D012970:Sodium Glutamate