title: [The estimation of selected parameters in antioxidant system in red blood cells in ROP screening of premature infants].
abstract: OBJECTIVE
  To estimate correlation between concentration of antioxidant system parameters in red blood cells in premature infants and prevalence of ROP MATERIAL AND METHODS: We examined 16 premature infants with the average birth weight of 1071 g and gestational age of 29.1 weeks. Supraoxide dismutase (SOD), reduced glutatione (GSH), and glutathione peroxidase (GSH-Px), were measured at day 1 (cord blood), 7-th and 14-th day after birth. Premature infants had ROP screening. The control group included 12 infants born at term.
  
  
  RESULTS
  8 premature infants had ROP There were higher levels of SOD, GSH and GSH-Px in premature infants with and without ROP than in control group. Premature infants with ROP had lowest levels of GSH.
  
  
  CONCLUSIONS
  The glutathione status of red blood cells as a oxidative stress index in premature infants might be a reliable parameter, facilitating the early recognition of patients in immediate danger of ROP development.
authors: Kliniki Okulistyki Dzieciecej Akademii Medycznej, Białymstoku.
authors: Monika
authors: M
authors: Oziebło-Kupczyk
authors: Alina
authors: A
authors: Bakunowicz-Lazarczyk
authors: Krystyna
authors: K
authors: Dzienis
authors: Elzbieta
authors: E
authors: Skrzydlewska
authors: Marek
authors: M
authors: Szczepański
authors: Ewa
authors: E
authors: Waszkiewiczz
mesh_terms: D000975:Antioxidants / Q000378:metabolism*; D015415:Biomarkers / Q000097:blood; D005260:Female; D005312:Fetal Blood / Q000737:chemistry; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000097:blood*; D008297:Male; D015997:Neonatal Screening / Q000379:methods*; D018384:Oxidative Stress; D011247:Pregnancy; D011248:Pregnancy Complications / Q000378:metabolism; D012178:Retinopathy of Prematurity / Q000097:blood* / Q000175:diagnosis*; D013482:Superoxide Dismutase / Q000097:blood
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase