title: Compact multimodal adaptive-optics spectral-domain optical coherence tomography instrument for retinal imaging.
abstract: We have developed a compact, multimodal instrument for simultaneous acquisition of en face quasi-confocal fundus images and adaptive-optics (AO) spectral-domain optical coherence tomography (SDOCT) cross-sectional images. The optical system including all AO and SDOCT components occupies a 60x60 cm breadboard that can be readily transported for clinical applications. The AO component combines a Hartmann-Shack wavefront sensor and a microelectromechanical systems-based deformable mirror to sense and correct ocular aberrations at 15 Hz with a maximum stroke of 4 microm. A broadband superluminescent diode source provides 4 mum depth resolution for SDOCT imaging. In human volunteer testing, we observed up to an 8 dB increase in OCT signal and a corresponding lateral resolution of <10 microm as a result of AO correction.
authors: Physical Sciences Inc., Andover, MA 01810, USA.
authors: Chad E
authors: CE
authors: Bigelow
authors: Nicusor V
authors: NV
authors: Iftimia
authors: R Daniel
authors: RD
authors: Ferguson
authors: Teoman E
authors: TE
authors: Ustun
authors: Benjamin
authors: B
authors: Bloom
authors: Daniel X
authors: DX
authors: Hammer
mesh_terms: D000328:Adult; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000295:instrumentation*; D007909:Lenses; D008297:Male; D008904:Miniaturization; D015203:Reproducibility of Results; D042261:Retinoscopes; D012680:Sensitivity and Specificity; D013050:Spectrometry, Fluorescence / Q000295:instrumentation* / Q000379:methods; D018511:Systems Integration; D041623:Tomography, Optical Coherence / Q000295:instrumentation* / Q000379:methods