HIV proviral DNA associated with decreased neuropsychological function.
The authors previously found a strong association between elevated HIV proviral DNA (HIV DNA) and a diagnosis of HIV-1-associated dementia (HAD) vs. normal cognition. It is unclear whether HIV DNA globally affects the diagnosis of HAD or whether the effect is limited to individual neuropsychological deficits. This exploratory study examined baseline HIV DNA and its association with individual neuropsychological deficits. HIV DNA was significantly associated with baseline neuropsychological deficits independent of age, ethnicity, IQ, and plasma HIV-1 RNA levels. However, HIV DNA did not predict future changes in neuropsychological deficits. The data suggest that HIV DNA and neuropsychological deficits may co-vary over time.
Shiramizu
Bruce
B
University of Hawaii, John A. Burns School of Medicine, Hawaii AIDS Clinical Research Program, 3675 Kilauea Avenue, Young Building, 5th Floor, Honolulu, HI 96816, USA. bshirami@hawaii.edu
Paul
Robert
R
Williams
Andrew
A
Shikuma
Cecilia
C
Watters
Michael
M
Grove
John
J
Valcour
Victor
V
D015526:AIDS Dementia Complex / Q000175:diagnosis* / Q000453:epidemiology*; D000328:Adult; D003430:Cross-Sectional Studies; D004279:DNA, Viral / Q000235:genetics*; D005260:Female; D015658:HIV Infections / Q000453:epidemiology* / Q000235:genetics*; D015497:HIV-1 / Q000235:genetics*; D006801:Humans; D017567:Karnofsky Performance Status; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D011533:Proviruses / Q000235:genetics*; D012367:RNA, Viral / Q000097:blood; D012720:Severity of Illness Index
D004279:DNA, Viral; D012367:RNA, Viral