Molecular basis for trehalase inhibition revealed by the structure of trehalase in complex with potent inhibitors.
Gibson
Robert P
RP
Department of Chemistry, York Structural Biology Laboratory, York, YO, UK.
Gloster
Tracey M
TM
Roberts
Shirley
S
Warren
R Anthony J
RA
Storch de Gracia
Isabel
I
García
Angela
A
Chiara
Jose L
JL
Davies
Gideon J
GJ
D002384:Catalysis; D003124:Colorimetry; D004187:Disaccharides / Q000037:antagonists & inhibitors / Q000737:chemistry; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D006860:Hydrogen Bonding; D007294:Inositol / Q000031:analogs & derivatives / Q000037:antagonists & inhibitors / Q000737:chemistry; D011487:Protein Conformation; D014198:Trehalase / Q000037:antagonists & inhibitors* / Q000737:chemistry*
D004187:Disaccharides; D004791:Enzyme Inhibitors; C071816:trehazolin; C030790:validamycin A; D007294:Inositol; D014198:Trehalase