Role of myeloid human cytomegalovirus infection in children's idiopathic thrombocytopenic purpura.
This project explores the specificity of myeloid human cytomegalovirus (HCMV) infection in pathogenesis of idiopathic thrombocytopenic purpura (ITP). Eighty-one subjects with ITP were observed. HCMV early antigen and related myeloid cells in bone marrow, and platelet, HCMV IgM, and IgG in blood were tested. The results presented potent evidence that myeloid HCMV infection is a specific factor in children's ITP: patients of ITP with myeloid HCMV infection had a tendency for exacerbation, refractoriness, and chronic advance. However, HCMV did not affect the quantity of megakaryocyte, which showed the complicated relationships between HCMV and ITP.
Ding
Yan
Y
Department of Gastroenterology and Hepatology, Wuhan Children's Hospital, Wuhan, Hubei Province, People's Republic of China.
Zhao
Lei
L
Mei
Hong
H
Zhang
Shu-Ling
SL
Huang
Zhi-Hua
ZH
D000293:Adolescent; D000914:Antibodies, Viral / Q000097:blood; D001792:Blood Platelets / Q000378:metabolism / Q000821:virology; D002648:Child; D002675:Child, Preschool; D003587:Cytomegalovirus / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D003586:Cytomegalovirus Infections / Q000150:complications* / Q000821:virology; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D007223:Infant; D008297:Male; D022423:Myeloid Cells / Q000378:metabolism / Q000821:virology*; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000175:diagnosis / Q000209:etiology*
D000914:Antibodies, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M