The role of the basal ganglia in bimanual coordination.
The functional anatomical role of the basal ganglia in bimanual coordination is unknown. Utilizing functional MRI (fMRI) at 3 T, we analyzed brain activity during three different typing tasks. The first task consisted of typing with parallel finger movements (moving left to right with four fingers on both hands). The second task was mirror movements (moving little finger to index finger on both hands), and the third task compared a resting condition with right-handed unimanual typing (moving little finger to index finger). Task dependent BOLD activity in the supplementary motor area (SMA) and dorsolateral premotor areas was observed. In addition, activation patterns were present in the cerebellar vermis during bimanual coordination tasks, with greater activation in the parallel than in the mirror condition. Finally, we also identified activity in the putamen during the tasks described above. Interestingly, putaminal activity was greatest during the period of motor task initiation, and activity during this period was greatest in the parallel condition. Our results suggest a critical role of the basal ganglia in the neural control of bimanual coordination.
Kraft
Eduard
E
Nuclear Magnetic Resonance Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA. eduard.kraft@med.uni-muenchen.de
Chen
Anthony W
AW
Flaherty
Alice W
AW
Blood
Anne J
AJ
Kwong
Kenneth K
KK
Jenkins
Bruce G
BG
D000328:Adult; D000704:Analysis of Variance; D001479:Basal Ganglia / Q000098:blood supply / Q000502:physiology*; D001931:Brain Mapping; D005260:Female; D005385:Fingers / Q000294:innervation; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009068:Movement / Q000502:physiology*; D010100:Oxygen / Q000097:blood; D011597:Psychomotor Performance / Q000502:physiology*; D013647:Task Performance and Analysis
D010100:Oxygen