title: Sulfasalazine-induced pericarditis in a patient with ulcerative colitis without recurrence when switching to mesalazine.
abstract: BACKGROUND
  Pericarditis is rarely reported in inflammatory bowel disease. Besides its common causes, pericarditis could be related to ulcerative colitis flare or to 5-aminosalicylic acid (5-ASA) treatment.
  
  
  METHODS
  We report the case of a patient in whom fever, weight loss and pericarditis developed after 16 years of treatment with sulfasalazine for ulcerative colitis, after increasing the daily dosage from 1 to 3 g.
  
  
  CONCLUSIONS
  The patient recovered after treatment discontinuation and did not exhibit any recurrence of pericarditis when treatment with mesalazine was introduced.
  
  
  CONCLUSIONS
  In conclusion, if pericarditis occurs in ulcerative colitis patients treated with 5-ASA compounds, the treatment should be considered as a possible cause, even after an increase of the dosage. In this case, discontinuation of the treatment and cautious switch to another 5-ASA compound should be tested.
authors: Service de Medecine Interne et Consultation de la Douleur, Hôtel Dieu, 1 Place du Parvis Notre Dame, 75004 Paris, France. serge.perrot@htd.aphp.fr
authors: Serge
authors: S
authors: Perrot
authors: Elisabeth
authors: E
authors: Aslangul
authors: Tali
authors: T
authors: Szwebel
authors: Houdha
authors: H
authors: Gadhoum
authors: Sophie
authors: S
authors: Romnicianu
authors: Claire
authors: C
authors: Le Jeunne
mesh_terms: D000636:Aminosalicylic Acids / Q000009:adverse effects / Q000627:therapeutic use*; D003093:Colitis, Ulcerative / Q000150:complications / Q000188:drug therapy / Q000517:prevention & control*; D006801:Humans; D008297:Male; D019804:Mesalamine / Q000627:therapeutic use*; D008875:Middle Aged; D010493:Pericarditis / Q000139:chemically induced*; D012008:Recurrence; D012460:Sulfasalazine / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D000636:Aminosalicylic Acids; D012460:Sulfasalazine; D019804:Mesalamine