title: Role of the ABC transporter PRP1 (ABCC7) in pentamidine resistance in Leishmania amastigotes.
abstract: Pentamidine is a second-line agent in the treatment of leishmaniasis whose mode of action and resistance mechanism are not well understood. In this work, we show that the intracellular ABC protein PRP1 (pentamidine resistance protein 1) (ABCC7) can confer resistance to pentamidine in Leishmania sp. parasites in the intracellular stage.
authors: Instituto de Medicina Tropical, Universidade de São Paulo, Av Dr Enéas de Carvalho Aguiar, 470, 4 andar, São Paulo, Brazil.
authors: Adriano C
authors: AC
authors: Coelho
authors: Nadine
authors: N
authors: Messier
authors: Marc
authors: M
authors: Ouellette
authors: Paulo C
authors: PC
authors: Cotrim
mesh_terms: D018528:ATP-Binding Cassette Transporters / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D000981:Antiprotozoal Agents / Q000494:pharmacology*; D002460:Cell Line; D004351:Drug Resistance / Q000235:genetics; D006801:Humans; D007891:Leishmania / Q000145:classification / Q000187:drug effects* / Q000254:growth & development*; D008264:Macrophages / Q000469:parasitology*; D009000:Monocytes / Q000469:parasitology; D021261:Parasitic Sensitivity Tests; D010419:Pentamidine / Q000494:pharmacology*; D015800:Protozoan Proteins / Q000235:genetics / Q000378:metabolism; D011993:Recombinant Fusion Proteins / Q000235:genetics / Q000378:metabolism
chemical_list: D018528:ATP-Binding Cassette Transporters; D000981:Antiprotozoal Agents; D015800:Protozoan Proteins; D011993:Recombinant Fusion Proteins; C480121:pentamidine resistance protein 1, Leishmania major; D010419:Pentamidine