Human herpesvirus 6 subtype A-associated myocarditis with 'apical ballooning'.
A 67-year-old woman who presented with acute chest pain is reported. Three days before admission, she suffered from a flu-like infection. Coronary angiography showed no coronary stenosis. Ventriculography showed moderately reduced left ventricular function characterized by the so-called 'apical ballooning'. Endomyocardial biopsies and polymerase chain reaction analysis of the plasma revealed an acute infection with human herpesvirus 6 subtype A. Histological and immunohistochemical analyses revealed myocarditis with areas of interstitial macrophages and fibrosis. The present case report links, for the first time, myocarditis with a human herpesvirus 6 subtype A infection and the appearance of apical ballooning.
Bigalke
Boris
B
Medizinische Klinik III, University Hospital of Tübingen, Tübingen, Germany. boris.bigalke@med.uni-tuebingen.de
Klingel
Karin
K
May
Andreas E
AE
Kandolf
Reinhard
R
Gawaz
Meinrad Gawaz
MG
D000368:Aged; D000787:Angina Pectoris / Q000209:etiology; D005260:Female; D015654:Herpesvirus 6, Human; D006801:Humans; D007150:Immunohistochemistry; D009205:Myocarditis / Q000473:pathology / Q000821:virology*; D019349:Roseolovirus Infections / Q000150:complications* / Q000473:pathology; D018487:Ventricular Dysfunction, Left / Q000821:virology*