title: Prevalence of the metabolic syndrome in Asian women with polycystic ovary syndrome: using the International Diabetes Federation criteria.
abstract: BACKGROUND
  Since insulin resistance and compensatory hyperinsulinemia are the major causes of the metabolic syndrome (MS) and are also the main pathophysiology of polycystic ovary syndrome (PCOS), PCOS women are at risk of MS. The aim of the present cross-sectional study was to determine the prevalence of MS in Asian women with PCOS using the International Diabetes Federation (IDF) criteria and to define the risk factors.
  
  
  METHODS
  One hundred and seventy women with PCOS were enrolled in the study from September 3, 2002 to June 14, 2005. A 75-g oral glucose tolerance test with plasma glucose and serum insulin levels was performed. Also, blood samples were examined for fasting triglycerides, high-density lipoprotein cholesterol and adiponectin levels.
  
  
  RESULTS
  The mean (+/-standard deviation) age, body mass index (BMI) and waist-to-hip ratio were 28.8+/-5.9 years, 27.1 +/- 7.0 kg/m(2) and 0.85+/-0.06, respectively. The prevalence of MS was 35.3%. Age, BMI, waist circumference and all metabolic parameters were higher in PCOS women with MS than in those without MS. MS prevalence increased with age, BMI and insulin resistance as determined by homeostasis model assessment (HOMA-IR), but not with adiponectin after BMI adjustment.
  
  
  CONCLUSIONS
  According to the IDF criteria, one-third of the PCOS women had MS. This study also showed that age, BMI and HOMA-IR are important risk factors for MS.
authors: Department of OB-GYN, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. raswt@mahidol.ac.th
authors: Sawaek
authors: S
authors: Weerakiet
authors: Pongamon
authors: P
authors: Bunnag
authors: Bunyong
authors: B
authors: Phakdeekitcharoen
authors: Surapee
authors: S
authors: Wansumrith
authors: Suwannee
authors: S
authors: Chanprasertyothin
authors: Rattiya
authors: R
authors: Jultanmas
authors: Ammarin
authors: A
authors: Thakkinstian
mesh_terms: D052242:Adiponectin / Q000097:blood; D000328:Adult; D044466:Asian People; D001786:Blood Glucose; D015992:Body Mass Index; D005260:Female; D005951:Glucose Tolerance Test / Q000379:methods; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D024821:Metabolic Syndrome / Q000175:diagnosis / Q000453:epidemiology* / Q000208:ethnology; D011085:Polycystic Ovary Syndrome / Q000175:diagnosis / Q000453:epidemiology* / Q000208:ethnology; D015995:Prevalence; D012307:Risk Factors; D013785:Thailand
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D001786:Blood Glucose; D007328:Insulin