Biotransformation of cinobufagin by Cunninghamella elegans.
Cunninghamella elegans has been employed for the biotransformation of cinobufagin to afford 5 metabolites. The structures of the transformation products have been characterized as 12alpha-hydroxybufagin, 11alpha-hydroxybufagin, 12beta-hydroxy-desacetylcinobufagin, 3-oxo-12alpha-hydroxybufagin and 12beta-hydroxybufagin. Products 12alpha-hydroxybufagin and 11alpha-hydroxybufagin are new compounds. In vitro both the biotransformation products and cinobufagin all showed cytotoxic activities against HeLa cells.
Qiao
Li
L
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University.
Zhou
Yu-Zhi
YZ
Qi
Xiu-Lan
XL
Lin
Li-Hong
LH
Chen
Huan
H
Pang
Li-Yan
LY
Pei
Yue-Hu
YH
D001711:Biotransformation; D002018:Bufanolides / Q000378:metabolism* / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D020093:Cunninghamella / Q000378:metabolism*; D006367:HeLa Cells; D006801:Humans; D013329:Structure-Activity Relationship
D002018:Bufanolides; C002471:cinobufagin