A new semisynthetic ocotillol-type saponin and resuscitation of haemorrhagic shock.
A new ocotillol-type saponin (PGQ) has been semisynthesised from 20(S)-ginsenoside Rg3 for the first time, in with a yield of 73%, by oxidation and cyclisation of the side-chain. Its structure was characterised by IR, HR-MS, (1)H NMR, (13)C NMR, (1)H-(1)H COSY, DEPT, HMBC and HMQC spectroscopy as 3-O-[beta-D-glucopyranosyl-(1-2)-beta-D-glucopyranosyl]-dammar- 20S,24S-epoxy-3beta,12beta,25-triol (1). The saponin produced a beneficial effect on resuscitation of haemorrhagic shock as follows: first, it could significantly rise increased mean arterial pressure; second, it could increased blood oxygen content; third, it could markedly decreased serum lipoperoxidase and increased superoxide dismutase (SOD) activities. Thus, the saponin had the effect of an anti-haemorrhagic shock.
Liu
J-P
JP
Research Department of Natural Medicine, Shenyang Pharmaceutical University, Shenyang, China.
Lu
D
D
Zhao
Y
Y
Li
P-Y
PY
Li
X
X
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004285:Dogs; D036145:Ginsenosides / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use*; D015394:Molecular Structure; D010100:Oxygen / Q000097:blood; D010544:Peroxidases / Q000187:drug effects; D012771:Shock, Hemorrhagic / Q000188:drug therapy*; D013482:Superoxide Dismutase / Q000187:drug effects
D036145:Ginsenosides; D010544:Peroxidases; D013482:Superoxide Dismutase; D010100:Oxygen