[Analysis of effectiveness of intracellular permeability of ivermectin immobilized on corpuscular carriers].
Penetration of ivermectin adsorbed on the surface of colloidal gold particles or included in micelles to phagocytic immune system cells was studied. Detection of the preparation in the cells was carried out by an immunochemical method, employing miniantibodies to ivermectin obtained from a combinatory phage library and by a chromatographic method on the HPLC system "Stayer". It was found that ivermectin adsorbed on colloidal gold particles was accumulated in the cells most intensively.
Pristenskiĭ
D V
DV
Staroverov
S A
SA
Ermilov
D N
DN
Shchegolev
S Iu
SIu
Dykman
L A
LA
D000818:Animals; D000977:Antiparasitic Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D002417:Cattle; D002463:Cell Membrane Permeability; D004337:Drug Carriers; D016503:Drug Delivery Systems; D017979:Gold Colloid; D066298:In Vitro Techniques; D007559:Ivermectin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D008214:Lymphocytes / Q000187:drug effects / Q000378:metabolism; D017737:Macrophages, Peritoneal / Q000378:metabolism; D008823:Micelles; D051381:Rats
D000977:Antiparasitic Agents; D004337:Drug Carriers; D017979:Gold Colloid; D008823:Micelles; D007559:Ivermectin