Anti-hypoxia and anti-oxidation effects of aminophylline on human with acute high-altitude exposure.
OBJECTIVE
To investigate the anti-hypoxia and anti-oxidation effects of aminophylline on human with acute high-altitude exposure.


METHODS
Totally 100 young male army members newly recruited from Sichuan province (400 meters above sea level) were enrolled. They were randomly divided into two groups: 50 in aminophylline group (A group) and 50 in control group (C group). A group and C group orally took aminophylline and placebo respectively for 10 days, 7 days before entering Lhasa (3 658 meters above sea level) by air and 3 days after it. Several parameters were measured at three time points: before drug taken, 7 days after drug taken, and 3 days after ascending high altitude. These parameters included serum levels of nitric oxide (NO), superoxide dismutase (SOD), catalase (CAT), hydrogen dioxide (H2O2), lactic acid (LA), as well as arterial oxygen saturation (SO2), arterial oxygen partial pressure (PaO2), and arterial carbon dioxide partial pressure (PaCO2). Statistical analysis was conducted to compare the difference between two groups with Stata 7.0 software system.


RESULTS
There were no statistical differences between groups in hypoxia and oxidation indicators before and after drug taken in plain area. Three days after ascending high altitude, the serum levels of SOD, CAT, H2O2, LA, PaCO2 increased in both groups, yet to a much larger degree in C group than A group (P < 0.01); and NO, SO2, PaO2 decreased more markedly in C group (P < 0.05 for NO, P < 0.0001 for SO2 and PaO2).


CONCLUSIONS
Aminophylline has significant anti-hypoxia and anti-oxidation effects at high altitude.
Yang
Bo
B
Department of Cardiology, General Hospital of People's Liberation Army, Beijing 100853. dryangb@yahoo.com.cn
Wang
Guang-Yi
GY
Chen
Bin
B
Qin
Rong-Bin
RB
Xi
Si Lang Zha
SL
Chen
Lian
L
D000208:Acute Disease; D000293:Adolescent; D000532:Altitude Sickness / Q000188:drug therapy* / Q000517:prevention & control*; D000628:Aminophylline / Q000627:therapeutic use*; D002245:Carbon Dioxide / Q000097:blood; D002374:Catalase / Q000097:blood; D006801:Humans; D009569:Nitric Oxide / Q000097:blood; D010100:Oxygen / Q000097:blood; D010313:Partial Pressure; D013482:Superoxide Dismutase / Q000097:blood; D055815:Young Adult
D002245:Carbon Dioxide; D000628:Aminophylline; D009569:Nitric Oxide; D002374:Catalase; D013482:Superoxide Dismutase; D010100:Oxygen