Antimicrobial and cytotoxic activity of agelasine and agelasimine analogs.
Agelasine and agelasimine derivatives with substantially less complicated terpenoid side chains compared to the naturally occurring compounds have been synthesized and their ability to inhibit growth of microorganisms and cancer cells has been studied. Compounds with excellent activity against cancer cell lines (MIC ca. 1 microM for the most potent compounds), including a drug resistant renal cell line, have been identified. Most compounds studied also exhibited broad spectrum antimicrobial activity including activity against Mycobacterium tuberculosis.
Vik
Anders
A
Department of Chemistry, University of Oslo, Blindern, N-0315 Oslo, Norway.
Hedner
Erik
E
Charnock
Colin
C
Tangen
Linda W
LW
Samuelsen
Ørjan
Ø
Larsson
Rolf
R
Bohlin
Lars
L
Gundersen
Lise-Lotte
LL
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D021241:Spectrometry, Mass, Electrospray Ionization
D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents