Switching gears: translational mastery of transcription during memory formation.
A critical molecular requirement underlying many forms of long-lasting synaptic plasticity and memory is the de novo synthesis of mRNAs and proteins. In a recent paper in Cell, Costa-Mattioli et al. present data from a pharmacogenetic study that places a key regulatory event in the "neural decision" to undergo these persistent neuronal changes under translational control mediated by eIF2alpha.
Hoeffer
Charles A
CA
Center for Neural Science, New York University, New York, NY 10003, USA.
Klann
Eric
E
D051701:Activating Transcription Factor 4 / Q000502:physiology; D000818:Animals; D017362:Cyclic AMP Response Element-Binding Protein / Q000502:physiology; D015852:Eukaryotic Initiation Factor-2 / Q000235:genetics / Q000502:physiology; D006801:Humans; D008568:Memory / Q000502:physiology*; D008570:Memory, Short-Term / Q000502:physiology; D051379:Mice; D018345:Mice, Knockout; D009419:Nerve Tissue Proteins / Q000096:biosynthesis; D009473:Neuronal Plasticity / Q000502:physiology; D010766:Phosphorylation; D014176:Protein Biosynthesis / Q000502:physiology*; D012333:RNA, Messenger / Q000096:biosynthesis*
C081452:Atf4 protein, mouse; D017362:Cyclic AMP Response Element-Binding Protein; D015852:Eukaryotic Initiation Factor-2; D009419:Nerve Tissue Proteins; D012333:RNA, Messenger; D051701:Activating Transcription Factor 4