title: Efficacy of 25% diluted fluticasone propionate 0.05% cream as wet-wrap treatment in cutaneous mastocytosis.
abstract: BACKGROUND
  Mastocytosis is a disorder that can be subdivided into two forms: cutaneous and systemic. Patients with cutaneous mastocytosis only may suffer from cosmetic problems. Topical steroid application has been shown to be effective in cases of limited skin lesions.
  
  
  METHODS
  A case-controlled pilot study was conducted during a 6-weeks treatment using diluted 25% fluticasone propionate 0.05% cream under wet-wrap occlusion in 5 adults and 6 children. Improvement was measured up to the 24th week after treatment using the SCORMA Index.
  
  
  RESULTS
  The results of this pilot study showed a partial but clear cosmetic improvement in 9 of the 11 patients. The mean SCORMA Index decreased after treatment from 38 to 26.
  
  
  CONCLUSIONS
  25% dilution of fluticasone propionate 0.05% cream under wet-wrap occlusion is an alternative treatment modality for alleviating the symptoms of cutaneous mastocytosis, but the improvement may be moderate and fall short of the patient's expectations.
authors: Department of Dermatology, MCA, Alkmaar, The Netherlands.
authors: Rogier
authors: R
authors: Heide
authors: Flora B
authors: FB
authors: de Waard-van der Spek
authors: Jan C
authors: JC
authors: den Hollander
authors: Bhupendra
authors: B
authors: Tank
authors: Arnold P
authors: AP
authors: Oranje
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000730:Androstadienes / Q000008:administration & dosage*; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D016022:Case-Control Studies; D002648:Child; D004643:Emollients; D000068298:Fluticasone; D006801:Humans; D034701:Mastocytosis, Cutaneous / Q000188:drug therapy*; D009779:Occlusive Dressings; D010865:Pilot Projects; D016896:Treatment Outcome
chemical_list: D000730:Androstadienes; D000893:Anti-Inflammatory Agents; D004643:Emollients; D000068298:Fluticasone