title: Asymptomatic conjunctival mucosa-associated lymphoid tissue-type lymphoma with presumed intraocular involvement.
abstract: OBJECTIVE
  To report a case of conjunctival mucosa-associated lymphoid tissue (MALT) lymphoma with presumed intraocular involvement.
  
  
  METHODS
  Observational case report.
  
  
  RESULTS
  A 73-year-old white man presented for a routine eye examination and was found to have a salmon-colored bulbar conjunctival mass of the left eye. Ultrasound showed a low-reflective mass with diffuse thickening of the ciliary body and choroid. Immunohistochemistry and flow cytometry of an incisional biopsy specimen suggested a polyclonal lesion. Treatment with topical steroids yielded no clinical improvement, and excisional biopsy was performed. A diagnosis of MALT lymphoma was made after polymerase chain reaction (PCR) analysis of the immunoglobulin heavy chain (IgH) locus revealed a clonal B-cell population.
  
  
  CONCLUSIONS
  Conjunctival MALT lymphoma can present without symptoms and can extend intraocularly. PCR analysis of the IgH locus can identify lesion clonality when immunohistochemistry and flow cytometry fail to do so.
authors: Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
authors: Pradeep
authors: P
authors: Ramulu
authors: Nicholas T
authors: NT
authors: Iliff
authors: W Richard
authors: WR
authors: Green
authors: Irene C
authors: IC
authors: Kuo
mesh_terms: D000368:Aged; D001402:B-Lymphocytes / Q000473:pathology; D002830:Choroid Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000532:radiotherapy; D002924:Ciliary Body / Q000000981:diagnostic imaging / Q000473:pathology*; D003230:Conjunctival Neoplasms / Q000473:pathology* / Q000532:radiotherapy; D005434:Flow Cytometry; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D007150:Immunohistochemistry; D018442:Lymphoma, B-Cell, Marginal Zone / Q000000981:diagnostic imaging / Q000473:pathology* / Q000532:radiotherapy; D008297:Male; D016133:Polymerase Chain Reaction; D014463:Ultrasonography; D014604:Uveal Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000532:radiotherapy
chemical_list: D007143:Immunoglobulin Heavy Chains