title: Synthesis, biological evaluation and molecular modeling studies of arylidene-thiazolidinediones with potential hypoglycemic and hypolipidemic activities.
abstract: New arylidene-thiazolidinediones (ATZDs) were synthesized and evaluated in the alloxan-induced hyperglycemia mice model. The molecular target taken into consideration is the nuclear PPAR-gamma whose crystallographic structure is available on the PDB database as 2PRG. Thus the hypoglycemic and hypolipidemic activities of compounds were compared with the result of their docking after removal of the co-crystallized ligand present in the 2PRG structure. Molecular modeling studies were carried out using the Autodock 3.0.5 and ADT 1.1 programs.
authors: Departamento de Química, Universidade Católica de Pernambuco, Brazil.
authors: Lúcia Fernanda C
authors: LF
authors: da Costa Leite
authors: Rosa Helena
authors: RH
authors: Veras Mourão
authors: Maria do Carmo Alves
authors: Mdo C
authors: de Lima
authors: Suely Lins
authors: SL
authors: Galdino
authors: Marcelo Zaldini
authors: MZ
authors: Hernandes
authors: Francisco
authors: F
authors: de Assis Rocha Neves
authors: Stéphanie
authors: S
authors: Vidal
authors: Jacques
authors: J
authors: Barbe
authors: Ivan
authors: I
authors: da Rocha Pitta
mesh_terms: D000496:Alloxan / Q000494:pharmacology; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000188:drug therapy; D004305:Dose-Response Relationship, Drug; D006860:Hydrogen Bonding; D007004:Hypoglycemic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use*; D000960:Hypolipidemic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use*; D008024:Ligands; D051379:Mice; D008958:Models, Molecular; D015394:Molecular Structure; D047493:PPAR alpha / Q000378:metabolism; D047495:PPAR gamma / Q000378:metabolism; D045162:Thiazolidinediones / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use*; D014280:Triglycerides / Q000097:blood
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D000960:Hypolipidemic Agents; D008024:Ligands; D047493:PPAR alpha; D047495:PPAR gamma; D045162:Thiazolidinediones; D014280:Triglycerides; D000496:Alloxan