Phosphinic platinum complexes with 8-thiotheophylline derivatives: synthesis, characterization, and antiproliferative activity.
The platinum mixed-phosphine complexes (SP-4,2)-[PtCl(8-MTT)(PPh3)(PTA)] (2) and cis-[Pt(8-MTT)2(PPh3)(PTA)] (3) (MTTH2 = 8-(methylthio)theophylline, PTA = 1,3,5-triaza-7-phosphaadamantane) have been prepared from the precursor cis-[PtCl2(PPh3)(PTA)] (1), which has been fully characterized by X-ray diffraction determination. Antiproliferative activity tests indicated that the presence of one lipophilic PPh3 and one hydrophilic PTA makes 1-3 more active than the analogues bearing two PPh3 or two PTA. The reactivity of cis-[PtCl2(PPh3)2], cis-[PtCl2(PTA)2], and cis-[PtCl2(PPh3)(PTA)] with the bis(thiopurines) bis(S-8-thiotheophylline)methane (MBTTH2), 1,2-bis(S-8-thiotheophylline)ethane (EBTTH2), and 1,3-bis(S-8-thiotheophylline)propane (PBTTH2) has also been investigated. New binuclear complexes have been prepared and identified by spectroscopic techniques and their antiproliferative activities on T2 and SKOV3 cell lines evaluated.
Bergamini
P
P
Dipartimento di Chimica dell'Università di Ferrara, via L. Borsari 46, 44100 Ferrara, Italy. p.bergamini@unife.it
Bertolasi
V
V
Marvelli
L
L
Canella
A
A
Gavioli
R
R
Mantovani
N
N
Mañas
S
S
Romerosa
A
A
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007202:Indicators and Reagents; D008024:Ligands; D008670:Metals / Q000737:chemistry; D008958:Models, Molecular; D010721:Phosphinic Acids / Q000737:chemistry* / Q000494:pharmacology*; D017671:Platinum Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D011687:Purines / Q000737:chemistry; D013806:Theophylline / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology
C483400:8-thiotheophylline; D000970:Antineoplastic Agents; D007202:Indicators and Reagents; D008024:Ligands; D008670:Metals; D010721:Phosphinic Acids; D017671:Platinum Compounds; D011687:Purines; D013806:Theophylline