title: Continuous infusion of methylprednisolone via paediatric parenteral nutrition: a pharmacokinetic animal study.
abstract: OBJECTIVE
  The aim of our study consisted to measure the pharmacokinetic parameters of methylprednisolone administered in a continuous infusion of a paediatric parenteral nutrition mixture for 24h in the rabbit.
  
  
  METHODS
  Fourteen rabbits were split into two groups and assigned a different administration vehicle (all-in-one or two-in-one nutrition mixture). We used USC PACK* pharmacokinetics software to compare the influence of the composition of the paediatric parenteral nutritional solutions on the values of the pharmacokinetic parameters of methylprednisolone.
  
  
  RESULTS
  Neither the steady-state plasma concentrations of methylprednisolone hemisuccinate nor the values of the pharmacokinetic parameters of methylprednisolone differed significantly when administered in two-in-one or all-in-one nutrition mixtures.
  
  
  CONCLUSIONS
  The composition of the nutritional medium had no discernable effect on the bioavailability of methylprednisolone. Neither the speed at which the steady-state plasma concentration was reached, nor the values of the pharmacokinetic parameters of methylprednisolone were significantly modified.
authors: Laboratoire de Pharmacie Clinique et Biotechnique, EA2416, Faculté de Médecine-Pharmacie, 28 Place Henri-Dunant, 63000, Clermont-Ferrand, France.
authors: Christophe
authors: C
authors: Gellis
authors: Valérie
authors: V
authors: Sautou-Miranda
authors: Nathalie
authors: N
authors: Bleyzac
authors: Jean-François
authors: JF
authors: Jarrige
authors: Régine
authors: R
authors: Minet-Quinard
authors: Jean
authors: J
authors: Chopineau
mesh_terms: D000818:Animals; D001682:Biological Availability; D002853:Chromatography, Liquid / Q000379:methods; D004195:Disease Models, Animal; D004338:Drug Combinations; D005938:Glucocorticoids / Q000493:pharmacokinetics*; D006801:Humans; D007263:Infusions, Parenteral / Q000379:methods; D008297:Male; D008657:Metabolic Clearance Rate; D008776:Methylprednisolone Hemisuccinate / Q000493:pharmacokinetics*; D010288:Parenteral Nutrition / Q000009:adverse effects / Q000379:methods*; D011817:Rabbits; D011897:Random Allocation; D013047:Specific Pathogen-Free Organisms
chemical_list: D004338:Drug Combinations; D005938:Glucocorticoids; D008776:Methylprednisolone Hemisuccinate