title: Assessment of the histological characteristics of coronary arterial plaque with severe calcification.
abstract: BACKGROUND
  Several studies have shown that rotational atherectomy (RA) is associated with higher rates of the slow-flow phenomenon and that ablated particles may be the possible cause. Intravascular ultrasound (IVUS) has an intrinsic limitation in assessing plaque morphology behind the calcification because of acoustic shadowing. Therefore, the purpose of this study was to investigate plaque characteristics behind severe calcification by histological examination.
  
  
  RESULTS
  One hundred eight coronary arterial segments from 40 human cadavers (24 males, 16 females, mean age 74+/-7 years) were examined. Serial images of IVUS were obtained and 18 severe calcified lesions were collected. Experienced observers quantitatively analyzed the lesions by computerized planimetry for fibrous, fibrofatty, calcification, and necrotic tissue area. Histologically, 15 of 18 severely calcified lesions (83%) had an extensive necrotic tissue containing large numbers of cholesterol crystals and microcalcifications; 16 of same 18 severely calcified lesions (89%) had fibrofatty tissue as well as calcification. The necrotic tissue occupied 14+/-13% and fibrofatty tissue occupied 13+/-11% of severely calcified lesions.
  
  
  CONCLUSIONS
  Necrotic core and fibrofatty tissue components "hidden" behind calcification might cause emboli-induced thrombus formation and distal flow disturbance during RA.
authors: Department of Cardiology, Kawasaki Medical School, Kurashiki, Japan. tteru@med.kawasaki-m.ac.jp
authors: Teruyoshi
authors: T
authors: Kume
authors: Hiroyuki
authors: H
authors: Okura
authors: Takahiro
authors: T
authors: Kawamoto
authors: Takashi
authors: T
authors: Akasaka
authors: Eiji
authors: E
authors: Toyota
authors: Yoji
authors: Y
authors: Neishi
authors: Nozomi
authors: N
authors: Watanabe
authors: Renan
authors: R
authors: Sukmawan
authors: Ryotaro
authors: R
authors: Yamada
authors: Yoshito
authors: Y
authors: Sadahira
authors: Kiyoshi
authors: K
authors: Yoshida
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002102:Cadaver; D002114:Calcinosis / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology*; D003324:Coronary Artery Disease / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology*; D003331:Coronary Vessels / Q000000981:diagnostic imaging / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D012720:Severity of Illness Index; D018084:Ultrasonography, Interventional