[The estimation of selected parameters in antioxidant system in red blood cells in ROP screening of premature infants].
OBJECTIVE
To estimate correlation between concentration of antioxidant system parameters in red blood cells in premature infants and prevalence of ROP MATERIAL AND METHODS: We examined 16 premature infants with the average birth weight of 1071 g and gestational age of 29.1 weeks. Supraoxide dismutase (SOD), reduced glutatione (GSH), and glutathione peroxidase (GSH-Px), were measured at day 1 (cord blood), 7-th and 14-th day after birth. Premature infants had ROP screening. The control group included 12 infants born at term.


RESULTS
8 premature infants had ROP There were higher levels of SOD, GSH and GSH-Px in premature infants with and without ROP than in control group. Premature infants with ROP had lowest levels of GSH.


CONCLUSIONS
The glutathione status of red blood cells as a oxidative stress index in premature infants might be a reliable parameter, facilitating the early recognition of patients in immediate danger of ROP development.
Oziebło-Kupczyk
Monika
M
Kliniki Okulistyki Dzieciecej Akademii Medycznej, Białymstoku.
Bakunowicz-Lazarczyk
Alina
A
Dzienis
Krystyna
K
Skrzydlewska
Elzbieta
E
Szczepański
Marek
M
Waszkiewiczz
Ewa
E
D000975:Antioxidants / Q000378:metabolism*; D015415:Biomarkers / Q000097:blood; D005260:Female; D005312:Fetal Blood / Q000737:chemistry; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000097:blood*; D008297:Male; D015997:Neonatal Screening / Q000379:methods*; D018384:Oxidative Stress; D011247:Pregnancy; D011248:Pregnancy Complications / Q000378:metabolism; D012178:Retinopathy of Prematurity / Q000097:blood* / Q000175:diagnosis*; D013482:Superoxide Dismutase / Q000097:blood
D000975:Antioxidants; D015415:Biomarkers; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase