Immune response gene polymorphisms in unrelated donor hematopoietic cell transplantation.
Immune response genes (IRG) play an important role in inflammation and control of infection after allogeneic transplantation. The International Histocompatibility Working Group (IHWG) in hematopoietic cell transplantation took a candidate gene approach to define the risks associated with genetic variation for a panel of well-characterized IRG.
Malkki
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Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. mmalkki@fhcrc.org
Gooley
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Dubois
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Horowitz
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Petersdorf
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EW
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D005260:Female; D005802:Genes, MHC Class II / Q000235:genetics*; D006086:Graft vs Host Disease / Q000235:genetics / Q000276:immunology; D019337:Hematologic Neoplasms / Q000235:genetics / Q000401:mortality / Q000628:therapy*; D018380:Hematopoietic Stem Cell Transplantation; D006650:Histocompatibility Testing; D006801:Humans; D007223:Infant; D008285:Major Histocompatibility Complex / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000235:genetics; D011110:Polymorphism, Genetic / Q000235:genetics*; D011379:Prognosis; D015996:Survival Rate; D014019:Tissue Donors