title: Relationship between serum IL-7 concentrations and lymphopenia upon different levels of HIV immune control.
abstract: Serum IL-7 levels correlate with T-cell depletion in HIV-infected individuals. In some patients, we observed that serum IL-7 decreases upon progression to AIDS, suggesting a role for IL-7 in T-cell maintenance in sporadic cases. Interestingly, IL-7 levels were significantly lower in stable long-term non-progressors (LTNP) than in patients who lost the LTNP status in a 3-year follow-up (P < 0.001), indicating that the serum IL-7 concentration might be a valuable marker for maintenance of the LTNP state.
authors: Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
authors: Caroline
authors: C
authors: Fluur
authors: Bence
authors: B
authors: Rethi
authors: Pham Hong
authors: PH
authors: Thang
authors: Nancy
authors: N
authors: Vivar
authors: Frida
authors: F
authors: Mowafi
authors: Lucia
authors: L
authors: Lopalco
authors: Caterina Uberti
authors: CU
authors: Foppa
authors: Anders
authors: A
authors: Karlsson
authors: Giuseppe
authors: G
authors: Tambussi
authors: Francesca
authors: F
authors: Chiodi
mesh_terms: D015415:Biomarkers / Q000097:blood; D018791:CD4 Lymphocyte Count; D005500:Follow-Up Studies; D015658:HIV Infections / Q000276:immunology*; D020276:HIV Long-Term Survivors; D015497:HIV-1; D006801:Humans; D015851:Interleukin-7 / Q000097:blood*; D018655:Lymphocyte Count; D008231:Lymphopenia / Q000276:immunology* / Q000821:virology
chemical_list: D015415:Biomarkers; D015851:Interleukin-7