title: [Difference in the CD4+T lymphocytes activation between long term non-progressors and typical progressors of HIV-1 infected patients].
abstract: OBJECTIVE
  To investigate the difference in the CD4+T lymphocytes activation between long term non progressors (LTNP) and typical progressors (TP) of HIV-1 infected patients.
  
  
  METHODS
  Twenty-four HIV-1 infected patients and 15 heathy control adults were tested and flow cytometry was used to detect the activation marker CD38 and CD4 count in blood samples taken from the patients and control. bDNA method was used to test the virus load in the plasma of patients.
  
  
  RESULTS
  The activation of CD4+T cells was positively correlated with virus load and negatively correlated with CD4 counts. Compared with normal controls, the activation of CD4+T cells was obviously increased in TP patients but not obviously changed in LTNP patients.
  
  
  CONCLUSIONS
  Compared with healthy controls, the activation of CD4+T cells in LTNP did not obviously increase. This maybe partially accounts for LTNP patients keeping a good state for a long time.
authors: Beijing You-an Hospital Affiliated to Capital University of Medical Sciences, Beijing 100054, China.
authors: Yan-mei
authors: YM
authors: Jiao
authors: Jun-liang
authors: JL
authors: Fu
authors: Zheng
authors: Z
authors: Zhang
authors: Hui
authors: H
authors: Zhang
authors: Lei
authors: L
authors: Jin
authors: Chun-bao
authors: CB
authors: Zhou
authors: Bao-yun
authors: BY
authors: Fu
authors: Fu-sheng
authors: FS
authors: Wang
authors: Hao
authors: H
authors: Wu
mesh_terms: D051997:ADP-ribosyl Cyclase 1 / Q000032:analysis; D000328:Adult; D018791:CD4 Lymphocyte Count; D015496:CD4-Positive T-Lymphocytes / Q000166:cytology / Q000276:immunology*; D005260:Female; D005434:Flow Cytometry; D015658:HIV Infections / Q000097:blood / Q000276:immunology* / Q000821:virology; D015497:HIV-1 / Q000235:genetics / Q000502:physiology*; D054884:Host-Pathogen Interactions; D006801:Humans; D008213:Lymphocyte Activation / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D012367:RNA, Viral / Q000097:blood; D013997:Time Factors; D019562:Viral Load; D055815:Young Adult
chemical_list: D012367:RNA, Viral; D051997:ADP-ribosyl Cyclase 1