The effect of sodium valproate on proton MRS visible neurochemical concentrations.
The effect of the antiepileptic medication sodium valproate (VPA) on the concentrations of cerebral metabolites was studied longitudinally in ten patients with epilepsy using proton magnetic resonance spectroscopy (MRS). Myo-inositol was found to be lower while taking VPA, although no relationship between the change in metabolite concentration, VPA dose or seizure control was observed. MRS findings should be interpreted in the light of administered medications.
Simister
Robert J
RJ
MRI Unit, The National Society for Epilepsy, and Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, London WC1N 3BG, UK.
McLean
Mary A
MA
Barker
Gareth J
GJ
Duncan
John S
JS
D000293:Adolescent; D000328:Adult; D000465:Algorithms; D000927:Anticonvulsants / Q000494:pharmacology*; D001923:Brain Chemistry / Q000187:drug effects*; D004151:Dipeptides / Q000378:metabolism; D004827:Epilepsy / Q000188:drug therapy / Q000378:metabolism*; D005260:Female; D018698:Glutamic Acid / Q000378:metabolism; D005973:Glutamine / Q000378:metabolism; D006801:Humans; D007294:Inositol / Q000378:metabolism; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D014635:Valproic Acid / Q000494:pharmacology*
D000927:Anticonvulsants; D004151:Dipeptides; D005973:Glutamine; C027172:isospaglumic acid; D018698:Glutamic Acid; D007294:Inositol; D014635:Valproic Acid