title: Morphological changes in the liver after the administration of piroxicam and its complexes with Bio-Ions Cu (II), Co (II), Zn (II) to the rats.
abstract: In this research we present the results of the liver histopathological examinations after the administration of the Piroxicam (Pirox) and its complex combinations with metal bio-ions Cu (II), Co (II), Zn (II) to rats (White Wistar, 150-180 gr.). The results of the histological investigations are presented separately for each compound revealing the modifications after 24 hours and after 7 days. The hepatic lesions are noted in the case of Zn-Pirox after 24 hours and after 7 days, as well. The complexes Cu-Pirox and Co-Pirox don't produce hepatic modifications either after 24 hours or after 7 days according to our histological investigations.
authors: School of Pharmacy, "I. Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca.
authors: Doina
authors: D
authors: Miere
authors: Lorena
authors: L
authors: Filip
authors: I
authors: I
authors: Baba
authors: Mariana
authors: M
authors: Boţoc
authors: Elena
authors: E
authors: Curea
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects*; D003035:Cobalt / Q000008:administration & dosage / Q000009:adverse effects*; D003300:Copper / Q000008:administration & dosage / Q000009:adverse effects*; D008099:Liver / Q000187:drug effects* / Q000473:pathology*; D023421:Models, Animal; D009336:Necrosis / Q000139:chemically induced; D010894:Piroxicam / Q000008:administration & dosage / Q000009:adverse effects*; D051381:Rats; D017208:Rats, Wistar; D015032:Zinc / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D010894:Piroxicam; D003035:Cobalt; D003300:Copper; D015032:Zinc