Successful cardiac transplantation in Barth syndrome--single-centre experience of four patients.
We describe four patients with Barth syndrome who have undergone successful orthotopic heart transplantation. Patients are one, seven, 12.5 and 14.7 yr post-transplantation. One episode of severe infection occurred. Renal dysfunction and coronary allograft vasculopathy do not appear accelerated over non-Barth patients. Despite withholding purine synthesis inhibitors, these patients have not demonstrated an increased rate of rejection.
Mangat
Jasveer
J
Cardiac Transplant, Great Ormond Street Hospital, London, UK.
Lunnon-Wood
Tracy
T
Rees
Philip
P
Elliott
Martin
M
Burch
Michael
M
D000293:Adolescent; D009202:Cardiomyopathies / Q000209:etiology* / Q000601:surgery*; D002648:Child; D002675:Child, Preschool; D040181:Genetic Diseases, X-Linked / Q000150:complications*; D016027:Heart Transplantation; D006801:Humans; D007223:Infant; D008297:Male; D008661:Metabolism, Inborn Errors / Q000150:complications*; D013577:Syndrome; D016896:Treatment Outcome