title: Evaluation of normal brain development by prenatal MR imaging.
abstract: OBJECTIVE
  The aim of this study was to describe the normal pattern of development and maturation of the foetal brain with respect to gestational age as assessed with magnetic resonance imaging (MRI) and to provide an overview of the possibilities of the technique.
  
  
  METHODS
  Foetal cerebral MRI was performed on 56 pregnant women between 19 and 37 weeks of gestation. Half-Fourier single-shot turbo spin-echo (HASTE), true fast imaging with steady precession (FISP), T1-weighted fast low angle shot (FLASH) two-dimensional (2D) and diffusion-weighted (DW) sequences with apparent diffusion coefficient (ADC) were obtained. Biometric parameters and developmental areas of the cerebral cortex were correlated to gestational age by using the Spearman rank correlation test.
  
  
  RESULTS
  We found a negative correlation between the germinal matrix/biparietal diameter ratio and gestational age and a positive correlation between the germinal and cortical matrix when expressed as external intraocular diameter ratio (R=0.452, p=0.02). The cortical mantle was correlated with biometric parameters, such as the biparietal diameter and the frontooccipital diameter, and with gestational age. The interhemispheric fissure, the parietooccipital fissure and the sylvian fissure were detectable by the 22nd week. In the grey matter, the mean ADC values varied from 1.76 x 10(-3) mm(2)/s (at week 19) to 0.89 x 10(-3) mm(2)/s (at week 37), whereas in the white matter, the values varied from 2.03 x 10(-3) mm(2)/s (at week 19) to 1.25 x 10(-3) mm(2)/s (at week 37).
  
  
  CONCLUSIONS
  MRI provides a reliable valuation of brain maturation during pregnancy.
authors: Dipartimento di Scienze Radiologiche, Università degli studi di Roma La Sapienza, Via Regina Elena 324, I-00161 Rome, Italy.
authors: L
authors: L
authors: Manganaro
authors: A
authors: A
authors: Perrone
authors: S
authors: S
authors: Savelli
authors: M
authors: M
authors: Di Maurizio
authors: C
authors: C
authors: Maggi
authors: L
authors: L
authors: Ballesio
authors: L M
authors: LM
authors: Porfiri
authors: C
authors: C
authors: De Felice
authors: E
authors: E
authors: Marinoni
authors: M
authors: M
authors: Marini
mesh_terms: D000293:Adolescent; D000328:Adult; D001699:Biometry; D001921:Brain / Q000196:embryology*; D002540:Cerebral Cortex / Q000196:embryology; D003627:Data Interpretation, Statistical; D005260:Female; D005325:Fetal Organ Maturity; D005865:Gestational Age; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011263:Pregnancy Trimester, Third; D011296:Prenatal Diagnosis; D011446:Prospective Studies