title: Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia.
abstract: We identified a duplication of the MYB oncogene in 8.4% of individuals with T cell acute lymphoblastic leukemia (T-ALL) and in five T-ALL cell lines. The duplication is associated with a threefold increase in MYB expression, and knockdown of MYB expression initiates T cell differentiation. Our results identify duplication of MYB as an oncogenic event and suggest that MYB could be a therapeutic target in human T-ALL.
authors: Human Genome Laboratory, Department of Molecular and Developmental Genetics, Vlaams Instituut voor Biotechnologie (VIB), Leuven, Belgium.
authors: Idoya
authors: I
authors: Lahortiga
authors: Kim
authors: K
authors: De Keersmaecker
authors: Pieter
authors: P
authors: Van Vlierberghe
authors: Carlos
authors: C
authors: Graux
authors: Barbara
authors: B
authors: Cauwelier
authors: Frederic
authors: F
authors: Lambert
authors: Nicole
authors: N
authors: Mentens
authors: H Berna
authors: HB
authors: Beverloo
authors: Rob
authors: R
authors: Pieters
authors: Frank
authors: F
authors: Speleman
authors: Maria D
authors: MD
authors: Odero
authors: Marijke
authors: M
authors: Bauters
authors: Guy
authors: G
authors: Froyen
authors: Peter
authors: P
authors: Marynen
authors: Peter
authors: P
authors: Vandenberghe
authors: Iwona
authors: I
authors: Wlodarska
authors: Jules P P
authors: JP
authors: Meijerink
authors: Jan
authors: J
authors: Cools
mesh_terms: D002454:Cell Differentiation / Q000235:genetics* / Q000276:immunology; D045744:Cell Line, Tumor; D022201:Chromosomes, Artificial / Q000235:genetics; D005434:Flow Cytometry; D018628:Gene Dosage; D020440:Gene Duplication; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics; D020570:Genes, myb / Q000235:genetics*; D005820:Genetic Testing; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000235:genetics*; D009154:Mutation / Q000235:genetics; D009693:Nucleic Acid Hybridization / Q000235:genetics; D034741:RNA, Small Interfering / Q000235:genetics; D018709:Statistics, Nonparametric; D013601:T-Lymphocytes / Q000473:pathology*
chemical_list: D034741:RNA, Small Interfering