Hypotony and choroidal detachment as a complication of topical combined timolol and dorzolamide.
OBJECTIVE
Hypotony with choroidal detachment is a rare complication of glaucoma medication. In this study, we report on a case which supports the hypothesis that has been proposed to explain this phenomenon.


METHODS
This study was designed as an observational case report.


METHODS
A woman with chronic glaucoma underwent trabeculectomy on both eyes. Low intraocular pressure (IOP) developed in 1 eye only, with no visual change for many years. After cataract surgery, the IOP increased, necessitating treatment with topical timolol 0.5% and dorzolamide 2%. She developed monocular hypotony and choroidal detachment 3 months later. This complication occurred in the eye that had previously had a low IOP and resolved completely when topical medication was stopped. The choroidal detachment recurred when rechallenged with the same medication.


CONCLUSIONS
Topical aqueous suppression therapy can result in hypotony and choroidal detachment in an eye in which relatively low IOP has been maintained for many years after glaucoma filtration surgery. The problem resolves on stopping the medication.
Sharma
Tarun
T
Department of Ophthalmology, Oxford Eye Clinic, Oxford, UK.
Salmon
John F
JF
D000319:Adrenergic beta-Antagonists / Q000009:adverse effects*; D000959:Antihypertensive Agents / Q000627:therapeutic use; D002257:Carbonic Anhydrase Inhibitors / Q000009:adverse effects*; D002387:Cataract Extraction; D015862:Choroid Diseases / Q000139:chemically induced*; D002908:Chronic Disease; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D005260:Female; D005902:Glaucoma, Open-Angle / Q000188:drug therapy; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D000077338:Latanoprost; D008875:Middle Aged; D015814:Ocular Hypotension / Q000139:chemically induced*; D009883:Ophthalmic Solutions / Q000009:adverse effects; D011461:Prostaglandins F, Synthetic / Q000627:therapeutic use; D012008:Recurrence; D013449:Sulfonamides / Q000009:adverse effects*; D013876:Thiophenes / Q000009:adverse effects*; D013999:Timolol / Q000009:adverse effects*; D014130:Trabeculectomy
D000319:Adrenergic beta-Antagonists; D000959:Antihypertensive Agents; D002257:Carbonic Anhydrase Inhibitors; D009883:Ophthalmic Solutions; D011461:Prostaglandins F, Synthetic; D013449:Sulfonamides; D013876:Thiophenes; D000077338:Latanoprost; D013999:Timolol; C062765:dorzolamide