Morphological changes in the liver after the administration of piroxicam and its complexes with Bio-Ions Cu (II), Co (II), Zn (II) to the rats.
In this research we present the results of the liver histopathological examinations after the administration of the Piroxicam (Pirox) and its complex combinations with metal bio-ions Cu (II), Co (II), Zn (II) to rats (White Wistar, 150-180 gr.). The results of the histological investigations are presented separately for each compound revealing the modifications after 24 hours and after 7 days. The hepatic lesions are noted in the case of Zn-Pirox after 24 hours and after 7 days, as well. The complexes Cu-Pirox and Co-Pirox don't produce hepatic modifications either after 24 hours or after 7 days according to our histological investigations.
Miere
Doina
D
School of Pharmacy, "I. Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca.
Filip
Lorena
L
Baba
I
I
Boţoc
Mariana
M
Curea
Elena
E
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects*; D003035:Cobalt / Q000008:administration & dosage / Q000009:adverse effects*; D003300:Copper / Q000008:administration & dosage / Q000009:adverse effects*; D008099:Liver / Q000187:drug effects* / Q000473:pathology*; D023421:Models, Animal; D009336:Necrosis / Q000139:chemically induced; D010894:Piroxicam / Q000008:administration & dosage / Q000009:adverse effects*; D051381:Rats; D017208:Rats, Wistar; D015032:Zinc / Q000008:administration & dosage / Q000009:adverse effects*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D010894:Piroxicam; D003035:Cobalt; D003300:Copper; D015032:Zinc