title: The poor prognosis of childhood-onset bipolar disorder.
abstract: OBJECTIVE
  We examined age of onset of bipolar disorder as a potential course-of-illness modifier with the hypothesis that early onset will engender more severe illness.
  
  
  METHODS
  A total of 480 carefully diagnosed adult outpatients with bipolar disorder (mean age, 42.5 +/- 11.6 years) were retrospectively rated for age of illness onset, time to first pharmacotherapy, and course of illness. Clinicians prospectively rated daily mood fluctuations over 1 year.
  
  
  RESULTS
  Of the 480 patients, 14% experienced onset in childhood (12 years or younger); 36% in adolescence (13 to 18 years); 32% in early adulthood (19 to 29 years); and 19% in late adulthood (after 30 years). Childhood-onset bipolar illness was associated with long delays to first treatment, averaging more than 16 years. The patients with childhood or adolescent onset reported more episodes, more comorbidities, and rapid cycling retrospectively; prospectively, they demonstrated more severe mania, depression, and fewer days well.
  
  
  CONCLUSIONS
  This study demonstrates that childhood onset of bipolar disorder is common and is associated with long delays to first treatment. Physicians and clinicians should be alert to a possible bipolar diagnosis in children in hopes of shortening the time to initiating treatment and perhaps ameliorating the otherwise adverse course of illness.
authors: Department of Health and Human Services, National Institutes of Health, National Institute of Mental Health, Biological Psychiatry Branch, Bethesda, MD 20892-1272, USA. levericg@mail.nih.gov
authors: Gabriele S
authors: GS
authors: Leverich
authors: Robert M
authors: RM
authors: Post
authors: Paul E
authors: PE
authors: Keck
authors: Lori L
authors: LL
authors: Altshuler
authors: Mark A
authors: MA
authors: Frye
authors: Ralph W
authors: RW
authors: Kupka
authors: Willem A
authors: WA
authors: Nolen
authors: Trisha
authors: T
authors: Suppes
authors: Susan L
authors: SL
authors: McElroy
authors: Heinz
authors: H
authors: Grunze
authors: Kirk
authors: K
authors: Denicoff
authors: Maria K M
authors: MK
authors: Moravec
authors: David
authors: D
authors: Luckenbaugh
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D001714:Bipolar Disorder / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy*; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D011379:Prognosis; D012720:Severity of Illness Index; D013997:Time Factors