Bispolides, novel 20-membered ring macrodiolide antibiotics from microbispora.
Seven new related compounds named bispolides A1, A2, A3, B1, B2a, B2b and B3, have been found in a culture of Microbispora sp. A34030, isolated from a Malaysian soil sample. The planar structures were elucidated to be new 20-membered ring macrodiolide antibiotics on the basis of MS and NMR spectroscopic analyses. These antibiotics showed a good anti-MRSA activity in vitro.
Okujo
Noriyuki
N
Iinuma
Hironobu
H
George
Annie
A
Eim
Khor Siew
KS
Li
Tan Lee
TL
Ting
Ng Szu
NS
Jye
Tan Chin
TC
Hotta
Kunimoto
K
Hatsu
Masahiro
M
Fukagawa
Yasuo
Y
Shibahara
Seiji
S
Numata
Keiichi
K
Kondo
Shinichi
S
D000192:Actinomycetales / Q000254:growth & development / Q000378:metabolism*; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D018942:Macrolides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013211:Staphylococcus aureus / Q000187:drug effects
D000900:Anti-Bacterial Agents; D018942:Macrolides; C520925:bispolide A1; C520926:bispolide B1; C520924:bispolide B3