title: [A long survival case of sigmoid colon cancer patient with initially unresectable hepatic metastases].
abstract: The prognosis of a colorectal cancer patient with unresectable hepatic metastases is extremely poor. To improve the prognosis, when the hepatic metastases were initially unresectable, we performed second-look hepatectomy (s-l hepatectomy) after neoadjuvant hepatic arterial 5-FU infusion plus UFT (HAI-PMC). Here, we report the case of a sigmoid colon cancer patient with initially unresectable hepatic metastases showing a prolonged survival (6.5 years) by second-look operation after HAI-PMC. A 57-year-old woman was diagnosed with sigmoid colon cancer with unresectable liver metastases. Sigmoidectomy and hepatic arterial catheterization were performed in the initial operation, and HAI-PMC was performed 6 months after. Metastatic foci of the liver had shrunk (90.9%), but solitary metastatic lung cancer was detected during HAI. As no other metastatic lesion was observed, partial resection of the liver and lung was performed as a second-look operation, 6 months after the initial operation. The woman continued venous infusion chemotherapy as an outpatient, and she survived for 6.5 years after the initial operation. This result suggests that strategic multidisciplinary treatment utilizing s-l hepatectomy after neoadjuvant chemotherapy can lead to better prognosis for colorectal cancer patients with hepatic metastases.
authors: Second Dept. of Surgery, Hyogo College of Medicine.
authors: Tsutomu
authors: T
authors: Oshima
authors: Masafumi
authors: M
authors: Noda
authors: Keita
authors: K
authors: Tanaka
authors: Takashi
authors: T
authors: Kuno
authors: Kiyoshi
authors: K
authors: Tsukamoto
authors: Akihiko
authors: A
authors: Hashimoto
authors: Makoto
authors: M
authors: Gega
authors: Toshihiko
authors: T
authors: Yagyuu
authors: Reigetsu
authors: R
authors: Yoshikawa
authors: Hiroki
authors: H
authors: Ikeuchi
authors: Hidenori
authors: H
authors: Yanagi
authors: Takehira
authors: T
authors: Yamamura
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000556:secondary; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D004338:Drug Combinations; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006498:Hepatectomy; D006499:Hepatic Artery; D006801:Humans; D007261:Infusions, Intra-Arterial; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary* / Q000601:surgery; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D024162:Second-Look Surgery; D012811:Sigmoid Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D017741:Survivors; D005641:Tegafur / Q000008:administration & dosage; D014498:Uracil / Q000008:administration & dosage
chemical_list: D004338:Drug Combinations; C096910:UFT(R) drug; D005641:Tegafur; D014498:Uracil; D005472:Fluorouracil