title: Lack of association between pseudoexfoliation syndrome and manganese superoxide dismutase polymorphism.
abstract: OBJECTIVE
  The aim of this clinical study was to investigate the possible association between manganese superoxide dismutase (Mn-SOD) enzyme polymorphism in the mitochondrial targeting sequence and pseudoexfoliation syndrome.
  
  
  METHODS
  Ala (GTT) or Val (GCT) polymorphism in the signal peptide of Mn-SOD gene was evaluated using a primer pair to amplify a 107-bp fragment followed by digestion with restriction enzyme NgoM IV.
  
  
  RESULTS
  The frequencies of Ala-9 and Val-9 variants and genotypes of Mn-SOD were similar in the controls and pseudoexfoliation syndrome patients.
  
  
  CONCLUSIONS
  These results suggest no major modifying role for the Mn-SOD gene polymorphism in patients with pseudoexfoliation syndrome.
authors: Department of Medical Biology and Genetics, Firat University Medical Faculty, Elazig, Turkey. hyuce@firat.edu.tr
authors: Huseyin
authors: H
authors: Yuce
authors: Ibrahim F
authors: IF
authors: Hepsen
authors: Ibrahim
authors: I
authors: Tekedereli
authors: Ugurcan
authors: U
authors: Keskin
authors: Halit
authors: H
authors: Elyas
authors: Omer
authors: O
authors: Akyol
mesh_terms: D000328:Adult; D000409:Alanine; D017889:Exfoliation Syndrome / Q000201:enzymology* / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D013482:Superoxide Dismutase / Q000235:genetics*; D014633:Valine
chemical_list: D013482:Superoxide Dismutase; D014633:Valine; D000409:Alanine