A beta-keto ester as a novel, efficient, and versatile ligand for copper(I)-catalyzed C-N, C-O, and C-S coupling reactions.
Employing ethyl 2-oxocyclohexanecarboxylate as a novel, efficient, and versatile ligand, the copper-catalyzed coupling reactions of various N/O/S nucleophilic reagents with aryl halides could be successfully carried out under mild conditions. A variety of products including N-arylamides, N-arylimidazoles, aryl ethers, and aryl thioethers were synthesized in good to excellent yields.
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Xin
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Department of Chemistry, Xixi Campus, Zhejiang University, Hangzhou 310028, People's Republic of China.
Bao
Weiliang
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D000577:Amides / Q000737:chemistry; D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D004952:Esters / Q000737:chemistry*; D008024:Ligands; D015394:Molecular Structure; D009584:Nitrogen / Q000737:chemistry*; D010100:Oxygen / Q000737:chemistry*; D011760:Pyrrolidinones / Q000737:chemistry; D013438:Sulfhydryl Compounds / Q000737:chemistry; D013455:Sulfur / Q000737:chemistry*
D000577:Amides; D004952:Esters; D008024:Ligands; D011760:Pyrrolidinones; D013438:Sulfhydryl Compounds; D013455:Sulfur; D002244:Carbon; D003300:Copper; C028537:2-pyrrolidone; D009584:Nitrogen; D010100:Oxygen