Simultaneous development of diabetic ketoacidosis and Hashitoxicosis in a patient treated with pegylated interferon-alpha for chronic hepatitis C.
Classical interferon-alpha has been shown to be correlated with the development of a variety of autoimmune disorders. A 38 year-old female patient developed simultaneously diabetic ketoacidosis and hyperthyroidism 5 mo following initiation of treatment with pegylated interferon-alpha and ribavirin for chronic hepatitis C. High titers of glutamic acid decarboxylase, antinuclear and thyroid (thyroid peroxidase and thyroglobulin) antibodies were detected. Antiviral treatment was withdrawn and the patient was treated with insulin for insulin-dependent diabetes mellitus and propranolol for hyperthyroidism. Twelve months after cessation of pegylated interferon-alpha therapy the patient was euthyroid without any medication but remained insulin-dependent.
Soultati
Aspasia S
AS
2nd Department of Internal Medicine, University of Athens, Medical School, Hippokration General Hospital, 114 Vas Sofias Avenues, 28 Achaias st, Athens 115 23, Greece.
Dourakis
Spyridon P
SP
Alexopoulou
Alexandra
A
Deutsch
Melanie
M
Archimandritis
Athanasios J
AJ
D000328:Adult; D000998:Antiviral Agents / Q000009:adverse effects*; D016883:Diabetic Ketoacidosis / Q000139:chemically induced*; D005260:Female; D019698:Hepatitis C, Chronic / Q000188:drug therapy*; D006801:Humans; D006980:Hyperthyroidism / Q000139:chemically induced*; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000009:adverse effects*; D011092:Polyethylene Glycols / Q000009:adverse effects*; D011994:Recombinant Proteins
D000998:Antiviral Agents; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D011092:Polyethylene Glycols; C100416:peginterferon alfa-2a