title: Possible linkage between the ability to change the period (tau) of the prolactin and cortisol rhythms in women and breast cancer risk.
abstract: The 24 h profiles of plasma hormone concentrations are rhythmic. The circadian period (tau) changes in development, with seasons, and in women with different stages of the menstrual cycle. It is known that the rhythms of prolactin and cortisol are sensitive to environmental time cues, such as changes in day length and phase; however, the importance of these changes is not yet understood. This study investigates whether there is a relation between the ability of a subject to respond to external cues that are associated with seasonal changes causing alteration of the rhythm's periods in cortisol and prolactin and the epidemiologically determined susceptibility to breast cancer. It is shown that the rhythmic output pattern of prolactin and cortisol in vivo is generated by more than one oscillator and structured by more than one rhythmic component. Each cohort of American women, classified on an epidemiologic basis as high risk (HR) or low risk (LR) to develop breast cancer, expresses different rhythmic output patterns of both variables, suggesting that the genetic background as defined by the risk state is related to differences in the circadian time structure, including the ability of the subject to change the rhythm's tau. The LR cohort exhibited a statistically significant change between seasons in the rhythm's tau of both the prolactin and cortisol patterns. In contrast, the HR cohort showed no change in the rhythm's tau between seasons for prolactin and cortisol patterns. These results show that in human beings, the presence of a circannual rhythm in the circadian time structure or the ability to adapt the circadian rhythmic pattern of these variables to external cues, such as seasons, is related to the partly genetically determined risk state to develop breast cancer and may be of importance for human health.
authors: Unit of Chronobiology, Department of Human Genetics and Molecular Medicine, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. lewyh@post.tau.ac.il
authors: Hadas
authors: H
authors: Lewy
authors: Erhard
authors: E
authors: Haus
authors: Israel E
authors: IE
authors: Ashkenazi
mesh_terms: D000293:Adolescent; D000328:Adult; D001943:Breast Neoplasms / Q000097:blood* / Q000209:etiology* / Q000503:physiopathology; D002940:Circadian Rhythm / Q000502:physiology*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D008875:Middle Aged; D011388:Prolactin / Q000097:blood*; D012307:Risk Factors; D012621:Seasons
chemical_list: D011388:Prolactin; D006854:Hydrocortisone