Memory CD4 T cells enhance primary CD8 T-cell responses.
CD4 T-cell help is required for optimal memory CD8 T-cell responses. We have found that engaging preexisting CD4 Th1, but not Th2, memory cells at the time of CD8 T-cell priming results in increased CD8 effector responses to both bacterial and viral pathogens. The enhanced responses are characterized by increased numbers of cytokine-producing, antigen-specific cells. These findings suggest that engaging endogenous memory Th1 cells may increase cellular responses in an immunotherapy or vaccination setting.
Krawczyk
Connie M
CM
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Room 318 Hill Pavilion, 380 South University Avenue, Philadelphia, PA 19104-4539, USA.
Shen
Hao
H
Pearce
Edward J
EJ
D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D003713:Dendritic Cells / Q000276:immunology; D007114:Immunization; D007156:Immunologic Memory; D008089:Listeria monocytogenes / Q000276:immunology / Q000472:pathogenicity; D008088:Listeriosis / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control; D008213:Lymphocyte Activation; D051379:Mice; D008810:Mice, Inbred C57BL; D010047:Ovalbumin / Q000276:immunology; D011425:Propionibacterium acnes / Q000276:immunology; D018417:Th1 Cells
D010047:Ovalbumin