[Magnetic resonance imaging of angiogenesis in tumors].
Tumor angiogenesis induces the proliferation of immature blood vessels that are both heterogeneous and leaky. These characteristics can be demonstrated by measuring the perfusion parameters with MRI. Perfusion MRI is usually performed with in T1-weighted dynamic imaging after bolus injection of an exogenous contrast agent such as gadolinium chelate. The perfusion parameters are obtained by semi-quantitative or quantitative analysis of the enhancement curves in the tumor and the arterial input. Perfusion can also be assessed without injecting a contrast agent using arterial spin labeling techniques, diffusion MRI, or BOLD (blood oxygen level dependent) MRI. However, these latter methods are limited by a low signal-to-noise ratio and problems with quantification. The main indication for perfusion MRI is the assessment of antiangiogenic and antivascular treatments. New possibilities for demonstrating angiogenic blood vessels are being opened by molecular imaging.
Huwart
L
L
Unité de Radiodiagnostic, Université Catholique de Louvain, Cliniques Universitaires St-Luc, Bruxelles, Belgique.
Michoux
N
N
Van Beers
B   E
B
D002614:Chelating Agents; D003287:Contrast Media / Q000008:administration & dosage; D038524:Diffusion Magnetic Resonance Imaging; D004338:Drug Combinations; D005682:Gadolinium; D006801:Humans; D018810:Magnetic Resonance Angiography; D009369:Neoplasms / Q000098:blood supply* / Q000473:pathology; D009389:Neovascularization, Pathologic / Q000175:diagnosis*; D010100:Oxygen / Q000097:blood; D012039:Regional Blood Flow / Q000502:physiology; D012680:Sensitivity and Specificity
D002614:Chelating Agents; D003287:Contrast Media; D004338:Drug Combinations; D005682:Gadolinium; D010100:Oxygen