Does chloroquine treatment influence the distribution of pyrimethamine-resistant P. falciparum parasites in the field?
In a limited case controlled but molecular study in symptomatic Tanzanian children, we found that those who had not previously received Chroloquine treatment had a higher proportion of parasitaemia. There was also a higher proportion of pyrimetamine-resistant P. falciparum parasites among those who had not received any treatment. This finding is paradoxical and the reasons for this observation are suggested.
Edoh
D
D
Ifakara Centre, Box 53, Ifakara, Tanzania.
Mshinda
H
H
Kitua
A
A