Immunogenetics of mycobacterial infections in the North Indian population.
Several lines of evidence highlight the genetic basis of risk to develop mycobacterial diseases. Human leukocyte antigen (HLA)-DR2 alleles (DRB1*1501 and DRB1*1502) have been found to be strongly associated with mycobacterial disease, especially the more severe forms such as lepromatous leprosy and multidrug-resistant pulmonary tuberculosis. In this study, DNA-based high-resolution typing techniques of polymerase chain reaction-sequence-specific oligonucleotide probe were used to determine the distribution of HLA-DR/DQ alleles in patients with leprosy and pulmonary tuberculosis. Analysis of different DR2 subtypes based on valine/glycine dimorphism at codon beta86 in pocket 1 of HLA-DR showed an inverse relationship of DR2 alleles with V/G as the severity of disease increased both in leprosy and in pulmonary tuberculosis.
Singh
M
M
Department of Transplant Immunology & Immunogenetics, All India Institute of Medical Sciences, New Delhi 110029, India.
Balamurugan
A
A
Katoch
K
K
Sharma
S K
SK
Mehra
N K
NK
D000483:Alleles; D016022:Case-Control Studies; D017931:DNA Primers; D006684:HLA-DR Antigens / Q000145:classification / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D007125:Immunogenetics; D007194:India; D007918:Leprosy / Q000235:genetics / Q000276:immunology*; D009164:Mycobacterium Infections / Q000235:genetics / Q000276:immunology*; D015345:Oligonucleotide Probes; D016133:Polymerase Chain Reaction; D014397:Tuberculosis, Pulmonary / Q000235:genetics / Q000276:immunology*
D017931:DNA Primers; D006684:HLA-DR Antigens; D015345:Oligonucleotide Probes