title: Germ versus soma decisions: lessons from flies and worms.
abstract: The early embryo is formed by the fusion of two germ cells that must generate not only all of the nonreproductive somatic cell types of its body but also the germ cells for the next generation. Therefore, embryo cells face a crucial decision: whether to develop as germ or soma. How is this fundamental decision made and germ cell fate maintained during development? Studies in the nematode worm Caenorhabditis elegans and fruit fly Drosophila identify some of the decision-making strategies, including segregation of a specialized germ plasm and global transcriptional regulation.
authors: Department of Biology, Indiana University, Bloomington, IN 47405, USA. sstrome@indiana.edu
authors: Susan
authors: S
authors: Strome
authors: Ruth
authors: R
authors: Lehmann
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000196:embryology* / Q000235:genetics; D029742:Caenorhabditis elegans Proteins / Q000378:metabolism; D002454:Cell Differentiation; D002455:Cell Division; D019070:Cell Lineage; D004330:Drosophila / Q000196:embryology* / Q000235:genetics; D029721:Drosophila Proteins / Q000378:metabolism; D004625:Embryo, Nonmammalian / Q000166:cytology* / Q000502:physiology; D047108:Embryonic Development; D018507:Gene Expression Regulation, Developmental; D005854:Germ Cells / Q000166:cytology* / Q000502:physiology; D015388:Organelles / Q000502:physiology; D014158:Transcription, Genetic
chemical_list: D029742:Caenorhabditis elegans Proteins; D029721:Drosophila Proteins