Brain activation during working memory after traumatic brain injury in children.
Eight children with moderate to severe traumatic brain injury (TBI) and eight matched, uninjured control children underwent fMRI during an N-back task to test effects of TBI on working memory performance and brain activation. Two patterns in the TBI group were observed. Patients whose criterion performance was reached at lower memory loads than control children demonstrated less extensive frontal and extrafrontal brain activation than controls. Patients who performed the same, highest (3-back) memory load as controls demonstrated more frontal and extrafrontal activation than controls. Our findings of performance and brain activation changes in children after TBI await longitudinal investigation.
Newsome
Mary R
MR
Cognitive Neuroscience Laboratory, Baylor College of Medicine, Houston, TX 77030, USA. mnewsome@bcm.tmc.edu
Scheibel
Randall S
RS
Hunter
Jill V
JV
Wang
Zhiyue J
ZJ
Chu
Zili
Z
Li
Xiaoqi
X
Levin
Harvey S
HS
D000293:Adolescent; D001143:Arousal / Q000502:physiology*; D001930:Brain Injuries / Q000503:physiopathology*; D001931:Brain Mapping; D016022:Case-Control Studies; D002648:Child; D005260:Female; D005625:Frontal Lobe / Q000293:injuries / Q000502:physiology* / Q000503:physiopathology; D015600:Glasgow Coma Scale; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D016555:Matched-Pair Analysis; D008570:Memory, Short-Term / Q000502:physiology*; D012016:Reference Values