Anti-inflammatory activity of Dalbergia lanceolaria bark ethanol extract in mice and rats.
Topical anti-inflammatory activity of Dalbergia lanceolaria Linn. bark ethanol extract was demonstrated in albino mice using TPA-, EPP- and AA-induced ear edema models. The systemic activity of extract was confirmed using acute and sub-acute anti-inflammatory models in albino rats. The ethanol extract exhibited significant systemic anti-inflammatory activity in Carrageenan-induced rat paw edema, by inhibition of histamine and prostaglandin phases of acute inflammation. The extract also showed significant activity against turpentine-induced exudative changes and no activity against granular tissue formation in cotton pellet-induced granuloma in albino rats. Thus, resultant anti-inflammatory activity might be due to effects on several mediators involving cyclo-oxygenase pathway resulting in prostaglandin formation and leukocyte migration from the vessels.
Kale
Mrudula
M
Plant Sciences Division, Agharkar Research Institute, Pune, India.
Misar
A V
AV
Dave
Vivek
V
Joshi
Maruti
M
Mujumdar
A M
AM
D000527:Alprostadil; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D016718:Arachidonic Acid; D002351:Carrageenan; D032561:Cotton Fiber; D035782:Dalbergia / Q000737:chemistry*; D004431:Ear, External / Q000473:pathology; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D000431:Ethanol; D005260:Female; D006099:Granuloma / Q000139:chemically induced / Q000188:drug therapy / Q000473:pathology; D006632:Histamine; D008297:Male; D051379:Mice; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin; D012997:Solvents; D013755:Tetradecanoylphorbol Acetate; D014425:Turpentine
D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D012997:Solvents; D016718:Arachidonic Acid; D012701:Serotonin; D000431:Ethanol; D006632:Histamine; D002351:Carrageenan; D000527:Alprostadil; D013755:Tetradecanoylphorbol Acetate; D014425:Turpentine