Circadian rhythms: per2bations in the liver clock.
A master circadian clock resides in the brain and is required to synchronize the clocks in peripheral tissues such as the liver. Until now, it has been unclear how the central clock synchronizes the peripheral ones. New work points to one of the core clock genes, mPer2, as an essential link in this chain.
Reddy
Akhilesh B
AB
Neurobiology Division, MRC Laboratory of Molecular Biology, Cambridge CB2 2QH, UK. areddy@cantab.net
Maywood
Elizabeth S
ES
D000818:Animals; D001683:Biological Clocks / Q000502:physiology*; D018797:Cell Cycle Proteins / Q000502:physiology; D002940:Circadian Rhythm; D006801:Humans; D008099:Liver / Q000502:physiology*; D009687:Nuclear Proteins / Q000502:physiology; D056950:Period Circadian Proteins; D013493:Suprachiasmatic Nucleus / Q000502:physiology; D014157:Transcription Factors / Q000502:physiology
D018797:Cell Cycle Proteins; D009687:Nuclear Proteins; C513312:Per2 protein, mouse; D056950:Period Circadian Proteins; D014157:Transcription Factors