title: Fibroblast growth factor (FGF)23 in patients with acromegaly.
abstract: Fibroblast growth factor (FGF)23 is a hormone that regulates serum phosphate and 1,25-dihydroxyvitamin D levels. Hyperphosphatemia is sometimes observed in patients with acromegaly while the detailed mechanism of this abnormal phosphate metabolism remains to be elucidated. We have measured FGF23 levels in 18 patients before and after the surgery for acromegaly. Serum GH, IGF-I and phosphate significantly decreased after the surgery. In addition, FGF23 also reduced by the surgery. These results indicate that deficient action of FGF23 is not the cause of deranged phosphate metabolism in patients with acromegaly.
authors: Division of Nephrology & Endocrinology, Department of Medicine, The University of Tokyo Hospital, Japan.
authors: Nobuaki
authors: N
authors: Ito
authors: Seiji
authors: S
authors: Fukumoto
authors: Manabu
authors: M
authors: Taguchi
authors: Akira
authors: A
authors: Takeshita
authors: Yasuhiro
authors: Y
authors: Takeuchi
authors: Shozo
authors: S
authors: Yamada
authors: Toshiro
authors: T
authors: Fujita
mesh_terms: D000172:Acromegaly / Q000097:blood* / Q000601:surgery; D000328:Adult; D000368:Aged; D005260:Female; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000097:blood*; D019382:Human Growth Hormone / Q000097:blood; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000032:analysis; D008297:Male; D008875:Middle Aged; D010710:Phosphates / Q000097:blood / Q000378:metabolism
chemical_list: C000717427:FGF23 protein, human; D010710:Phosphates; D019382:Human Growth Hormone; D005346:Fibroblast Growth Factors; D007334:Insulin-Like Growth Factor I; D000089703:Fibroblast Growth Factor-23