ADAR editing wobbles the microRNA world.
Recent work reveals that adenosine-to-inosine editing occurs in a number of cellular microRNAs (miRNAs). Such editing is shown to diminish the expression of one miRNA and alter the target specificity of another. This changes our current views significantly by not only increasing the repertoire of miRNAs and their potential targets, but also providing mechanisms for how to regulate them and direct them to alternative targets.
Das
Asis K
AK
Department of Molecular, Microbial, and Structural Biology, University of Connecticut Health Center, Farmington, Connecticut 06030, USA.
Carmichael
Gordon G
GG
D000243:Adenosine Deaminase / Q000502:physiology*; D020868:Gene Silencing; D035683:MicroRNAs / Q000502:physiology*; D017393:RNA Editing / Q000502:physiology; D034622:RNA Interference; D016601:RNA-Binding Proteins
D035683:MicroRNAs; D016601:RNA-Binding Proteins; C567955:ADARB1 protein, human; D000243:Adenosine Deaminase