CaR talk: the calcium receptor finds new places to park.
The study by Tu et al. in this issue details the surprising finding that not only is the CaR active intracellularly but also its intracellular localization includes both the ER, traditionally thought of as the main intracellular Ca2+ signaling store, and the Golgi, more recently shown to be important in keratinocyte signaling.
Mauro
Theodora M
TM
Department of Dermatology, University of California at San Francisco, San Francisco, California 94121, USA. maurot@derm.ucsf.edu
D002118:Calcium / Q000378:metabolism; D020013:Calcium Signaling / Q000502:physiology*; D000252:Calcium-Transporting ATPases / Q000502:physiology; D002454:Cell Differentiation / Q000502:physiology; D004721:Endoplasmic Reticulum / Q000502:physiology*; D006056:Golgi Apparatus / Q000502:physiology*; D006801:Humans; D015603:Keratinocytes / Q000502:physiology; D044169:Receptors, Calcium-Sensing / Q000502:physiology*
D044169:Receptors, Calcium-Sensing; D000252:Calcium-Transporting ATPases; D002118:Calcium