Ring-closing olefin metathesis for the synthesis of benzene derivatives.
Benzene derivatives were synthesized in excellent yield from 1,4,7-trien-3-ols by tandem ruthenium-catalyzed ring-closing olefin metathesis (RCM)/dehydration. The method was extended to the tandem RCM/oxidation process to obtain phenol and aniline derivatives. This method displays many advantages over aromatic-substitution-based classical routes.
Yoshida
Kazuhiro
K
Department of Chemistry, Faculty of Science, Chiba University, Yayoi-cho, Inage-ku, Chiba 263-8522, Japan. kyoshida@faculty.chiba-u.jp
Kawagoe
Fumihiro
F
Iwadate
Noriyuki
N
Takahashi
Hidetoshi
H
Imamoto
Tsuneo
T