[Effects of yiqimingmu solution on models of light damage in rat retina].
OBJECTIVE
To investigate the experimental therapeutic effects of Chinese medicine Yiqimingmu solution on rats of retina injury models induced by light.


METHODS
Fifty-four Sprague-Dawley rats were randomly divided into negative control group, light damage model group and Yiqimingmu solution group. The light damage model was induced by exposing the SD rats' light eyes to the light of green fluorescent (intensity = 1900 +/- 106.9 Lux) for 24 hours. Distilled water and Yiqimingmu solution were respectively irrigated into rats for 7 days before light expose. In 6 days after light expose, the change of electroretinogram (ERG) was observed. The content of malondialdehyde (MDA) and activity of superoxide dismutase (SOD) in rats retina were measured, and the histopathologic changes were observed with transmission electron microscopy and light microscopy.


RESULTS
In 6 days after light expose, Yiqimingmu solution had protective effects on fall of ERG a wave and b wave amplitude induced by light damage. The activity of SOD in Yiqimingmu solution group was higher than in light damage model group (P < 0.01= , the content of MDA in Yiqimingmu solution group was lower than in light damage model group (P < 0.01). The histopathologic injury of rat retina in Yiqimingmu solution group was less than in light damage model group by means of transmission electron microscopy and light microscopy.


CONCLUSIONS
Yiqimingmu solution is an effective traditional Chinese medicine to treat diseases of retina light damage.
Wang
Yandong
Y
Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China.
Tang
Xilan
X
Wu
Wei
W
Ye
Chengtian
C
D000818:Animals; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D008027:Light; D008315:Malondialdehyde / Q000032:analysis; D008517:Phytotherapy; D011833:Radiation Injuries, Experimental / Q000188:drug therapy* / Q000473:pathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012160:Retina / Q000187:drug effects / Q000528:radiation effects; D012164:Retinal Diseases / Q000188:drug therapy* / Q000473:pathology; D013482:Superoxide Dismutase / Q000378:metabolism
D004365:Drugs, Chinese Herbal; C530867:yiqi mingmu; D008315:Malondialdehyde; D013482:Superoxide Dismutase