Reactivation versus primary CMV infection after splenectomy in immunocompetent patients.
Acute CMV infection in the immunocompetent host is usually asymptomatic or produces only mild symptoms. CMV infection in immunocompromized patients, especially transplant recipients and those infected with HIV, is a result of profound lymphopenia or dysfunction of CD4+/CD8+ cells and can cause substantial rates of complication and death. We present a case of CMV infection in a previously healthy man who just had splenectomy for blunt trauma: a short incubation of the CMV disease, a strongly positive CMV antigenemia, severity of the disease including prominent lymphocytosis, massive hepatic sinusoidal infiltration, and retinitis. Splenectomy changed the immunological defense against the virus and brought the infection to nearly fulminant scale.
Assy
N
N
Sieff Government Hospital Liver Unit, Safed, Israel. assy.n@ziv.health.gov.il
Gefen
H
H
Schlesinger
S
S
Karim
W
W
D000007:Abdominal Injuries / Q000601:surgery; D000328:Adult; D000914:Antibodies, Viral / Q000276:immunology*; D000998:Antiviral Agents / Q000008:administration & dosage; D016516:CD4-CD8 Ratio; D003587:Cytomegalovirus / Q000235:genetics / Q000276:immunology*; D003586:Cytomegalovirus Infections / Q000188:drug therapy / Q000209:etiology* / Q000821:virology; D004279:DNA, Viral / Q000235:genetics; D005500:Follow-Up Studies; D015774:Ganciclovir / Q000008:administration & dosage; D006801:Humans; D007121:Immunocompetence; D007275:Injections, Intravenous; D008297:Male; D011183:Postoperative Complications; D013154:Spleen / Q000293:injuries / Q000601:surgery; D013156:Splenectomy / Q000009:adverse effects*; D014949:Wounds, Nonpenetrating / Q000601:surgery
D000914:Antibodies, Viral; D000998:Antiviral Agents; D004279:DNA, Viral; D015774:Ganciclovir