Cold heparinized lactated Ringers with procaine (HeLP) preservation fluid in 266 living donor kidney transplantations.
Since the 1960s simple inexpensive cold lactated Ringers with additives has been used for short-term cold preservation of kidneys from living donors. We performed 266 living donor kidney transplantations from January 22, 2003 to October 30, 2006. Donor allografts were recovered laparoscopically and flushed with cold heparin, lactated Ringer's and procaine (HeLP) solution. Warm and cold ischemic times were typically <45 min and <90 min, respectively. The mean follow up was 21.6+/-12.2 months. There was no delayed graft function. Actuarial 1-year patient and graft survival were 98.6% and 98.1%, respectively. The creatinine at 1 year was 1.46+/-0.51 mg/dL. The cumulative incidences of acute cellular rejection at 6, 12, 18, and 24 months were 3.0%, 7.1%, 10.2%, and 11.7%. There were no identifiable side effects attributed to the HeLP solution. This study documents the effectiveness of cold HeLP as a flushing and short-term preservation fluid for living donor kidney transplantation with excellent results and significant cost benefit because of its low cost.
Tan
Henkie P
HP
The Thomas E. Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA. tanhp@upmc.edu
Vyas
Dinesh
D
Basu
Amit
A
Randhawa
Parmjeet
P
Shah
Nirav
N
Donaldson
Joseph
J
Marcos
Amadeo
A
Simmons
Richard L
RL
Starzl
Thomas E
TE
Shapiro
Ron
R
D001215:Asparaginase; D003080:Cold Temperature; D005500:Follow-Up Studies; D006493:Heparin / Q000494:pharmacology*; D006801:Humans; D007552:Isotonic Solutions / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects; D016030:Kidney Transplantation / Q000379:methods*; D019520:Living Donors; D009926:Organ Preservation / Q000379:methods*; D011343:Procaine / Q000494:pharmacology*; D000077325:Ringer's Lactate
D007552:Isotonic Solutions; D000077325:Ringer's Lactate; D011343:Procaine; D006493:Heparin; D001215:Asparaginase