Peripheral lung cancer: relationship between multi-slice spiral CT perfusion imaging and tumor angiogenesis and cyclin D1 expression.
The aim of this study was to investigate the relationship between 16-slice spiral CT perfusion imaging and tumor angiogenesis and cyclin D1 expression in patients with peripheral lung cancer. Fifty-eight patients with peripheral lung cancer underwent 16-slice spiral CT perfusion imaging. The CT perfusion imaging was analyzed for time density curve (TDC), perfusion parametric maps, and the respective perfusion parameters. Correlation between the respective perfusion parameters and immunohistochemical findings of microvessel density measurement and cyclin D1 expression was evaluated.
Ma
Shu-Hua
SH
Department of Radiology, First Affiliated Hospital, Medical College of Shantou University, Shantou 515041, China.
Xu
Ke
K
Xiao
Zhuang-Wei
ZW
Wu
Min
M
Sun
Zheng-Yu
ZY
Wang
Zhao-Xin
ZX
Hu
Zhi-Guo
ZG
Dai
Xu
X
Han
Ming-Jun
MJ
Li
Yu-Guang
YG
D000230:Adenocarcinoma / Q000098:blood supply / Q000000981:diagnostic imaging / Q000378:metabolism; D000328:Adult; D000368:Aged; D018287:Carcinoma, Large Cell / Q000098:blood supply / Q000000981:diagnostic imaging / Q000378:metabolism; D018288:Carcinoma, Small Cell / Q000098:blood supply / Q000000981:diagnostic imaging / Q000378:metabolism; D019938:Cyclin D1 / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000098:blood supply / Q000000981:diagnostic imaging / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000000981:diagnostic imaging*; D036542:Tomography, Spiral Computed / Q000379:methods*
D019938:Cyclin D1