title: Telomere dynamics in macaques and humans.
abstract: In humans, telomere length in proliferating tissues shortens with age--a process accelerated with age-related diseases. Thus, telomere length and attrition with age in the nonhuman primate may serve as a useful paradigm for understanding telomere biology in humans. We examined telomere parameters in tissues of young and old Macaca fascicularis and compared them with several tissues from humans. Macaque telomeres were variable in length and exhibited partial synchrony (equivalence) within animals. They were longer than humans, partially because of longer subtelomeric segments. As skeletal muscle telomere length was unchanged with age, we used it as an internal reference to offset interanimal variation in telomere length. We identified age-dependent telomere attrition in lung, pancreas, skin, and thyroid. Similar to humans, telomerase activity was detected in spleen, thymus, digestive tract, and gonads. We conclude that factors that modify telomere attrition and aging in humans may also operate in the macaque.
authors: The Center of Human Development and Aging, Cell Biology and Molecular Medicine, Department of Preventive Medicine and Community Health, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA. gardner@umdnj.edu
authors: Jeffrey P
authors: JP
authors: Gardner
authors: Masayuki
authors: M
authors: Kimura
authors: Weihang
authors: W
authors: Chai
authors: Jameel F
authors: JF
authors: Durrani
authors: Levon
authors: L
authors: Tchakmakjian
authors: Xiaojian
authors: X
authors: Cao
authors: Xiaobin
authors: X
authors: Lu
authors: Guanghui
authors: G
authors: Li
authors: Athanasios P
authors: AP
authors: Peppas
authors: Joan
authors: J
authors: Skurnick
authors: Woodring E
authors: WE
authors: Wright
authors: Jerry W
authors: JW
authors: Shay
authors: Abraham
authors: A
authors: Aviv
mesh_terms: D000368:Aged; D000375:Aging / Q000502:physiology; D000818:Animals; D005260:Female; D006801:Humans; D008252:Macaca fascicularis / Q000235:genetics* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length; D020133:Reverse Transcriptase Polymerase Chain Reaction; D019098:Telomerase / Q000378:metabolism; D016615:Telomere / Q000502:physiology*; D014018:Tissue Distribution
chemical_list: D019098:Telomerase