Purification by ozonolysis of (18)O enriched water after cyclotron irradiation and the utilization of the purified water for the production of [18F]-FDG (2-deoxy-2-[18F]-fluoro-d-glucose).
The high cost of virgin (18)O-enriched water has forced many researchers to study methods to purify and recycle enriched water after the first irradiation for the production of radiopharmaceuticals. In our study, [(18)O]H(2)O was purified by ozonolysis and distillation. Analyses showed a large decrease in impurities after this treatment. The purification procedure was carried out after the production of 94 batches of [18F]-FDG, which were manufactured using a GE Minitrace cyclotron and a GE Mx TracerLab synthesizer. Saturation yields after bombardment, using virgin and re-purified water were, respectively, 2864+/-204MBq/muA and 2727+/-167MBq/muA, a decrease of 5.5%. The decrease in [18F]-FDG yield, from 67.2+/-0.7% to 65.5+/-0.9%, can be ascribed to the irradiation step only.
Asti
M
M
Nuclear Medicine Department, Santa Maria Nuova Hospital via Risorgimento 80, 42100 Reggio Emilia, Italy.
Grassi
E
E
Sghedoni
R
R
De Pietri
G
G
Fioroni
F
F
Versari
A
A
Borasi
G
G
Salvo
D
D
D017357:Cyclotrons; D019788:Fluorodeoxyglucose F18 / Q000737:chemistry*; D010103:Oxygen Isotopes / Q000737:chemistry*; D019275:Radiopharmaceuticals / Q000737:chemistry*; D014867:Water / Q000737:chemistry*
D010103:Oxygen Isotopes; D019275:Radiopharmaceuticals; D014867:Water; D019788:Fluorodeoxyglucose F18