title: Synthesis of new S-derivatives of clubbed triazolyl thiazole as anti-Mycobacterium tuberculosis agents.
abstract: In the present study, a series of N-{4-[(4-amino-5-sulfanyl-4H-1,2,4-triazol-3-yl)methyl]-1,3-thiazol-2-yl}-2-substituted-amide (1a-d) derivatives were synthesized in good yields and characterized by IR, 1H NMR, mass spectral and elemental analyses. The compounds were evaluated for their preliminary in vitro antibacterial activity against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Salmonella typhosa and then were screened for antitubercular activity against Mycobacterium tuberculosis H37 Rv strain by broth microdilution assay method. The antibacterial data of the tested compounds indicated that most of the synthesized compounds showed better activity against bacteria compared to reference drugs. The in vitro antitubercular activity reports of tested compounds against M. tuberculosis strain H37 Rv showed moderate to better activity.
authors: Dr. Reddy's Laboratories, 7-1-27, Ameerpet, Hyderabad 500016, India.
authors: Mahendra Ramesh
authors: MR
authors: Shiradkar
authors: Kiran Kumar
authors: KK
authors: Murahari
authors: Hanimi Reddy
authors: HR
authors: Gangadasu
authors: Tatikonda
authors: T
authors: Suresh
authors: Chakravarthy Akula
authors: CA
authors: Kalyan
authors: Dolly
authors: D
authors: Panchal
authors: Ranjit
authors: R
authors: Kaur
authors: Prashant
authors: P
authors: Burange
authors: Jyoti
authors: J
authors: Ghogare
authors: Vinod
authors: V
authors: Mokale
authors: Mayuresh
authors: M
authors: Raut
mesh_terms: D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D013844:Thiazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000995:Antitubercular Agents; D013844:Thiazoles