title: Resistance of cardiac cells to NCX knockout: a model study.
abstract: The effects of NCX knockout were determined in a variety of cardiac cell models. Those of the mouse and rat ventricles, and of atrial cells in other species behave similarly to the experiments on mouse ventricle showing only small effects, and considerable tolerance of NCX knockout. Models of ventricular cells with high action potential plateaus, however, are more sensitive and require compensatory mechanisms to adjust other conductance parameters to enable the cells to resist NCX knockout. The effects can therefore be expected to be species-specific, and it is not possible to extrapolate the mouse results to those that may occur in the Guinea pig or human.
authors: Department of Physiology, Anatomy and Genetics, University of Oxford, Parks Road, Oxford, OX1 3PT, UK. Denis.noble@physiol.ox.ac.uk
authors: Denis
authors: D
authors: Noble
authors: Nobuaki
authors: N
authors: Sarai
authors: Penelope J
authors: PJ
authors: Noble
authors: Tsutomu
authors: T
authors: Kobayashi
authors: Satoshi
authors: S
authors: Matsuoka
authors: Akinori
authors: A
authors: Noma
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified; D006801:Humans; D051379:Mice; D009206:Myocardium / Q000378:metabolism*; D019831:Sodium-Calcium Exchanger / Q000235:genetics / Q000502:physiology*
chemical_list: D019831:Sodium-Calcium Exchanger