Crosstalk between xenobiotics metabolism and circadian clock.
Many aspects of physiology and behavior in organisms from bacteria to man are subjected to circadian regulation. Indeed, the major function of the circadian clock consists in the adaptation of physiology to daily environmental change and the accompanying stresses such as exposition to UV-light and food-contained toxic compounds. In this way, most aspects of xenobiotic detoxification are subjected to circadian regulation. These phenomena are now considered as the molecular basis for the time-dependence of drug toxicities and efficacy. However, there is now evidences that these toxic compounds can, in turn, regulate circadian gene expression and thus influence circadian rhythms. As food seems to be the major regulator of peripheral clock, the possibility that food-contained toxic compounds participate in the entrainment of the clock will be discussed.
Claudel
Thierry
T
Department of Pediatrics, Research Laboratory, University Medical Center Groningen, Groningen, ND-9700 RB, The Netherlands.
Cretenet
Gaspard
G
Saumet
Anne
A
Gachon
Frédéric
F
D000375:Aging; D000818:Animals; D001683:Biological Clocks / Q000187:drug effects / Q000235:genetics*; D002940:Circadian Rhythm / Q000187:drug effects / Q000235:genetics*; D005502:Food / Q000633:toxicity*; D015870:Gene Expression / Q000187:drug effects; D005786:Gene Expression Regulation; D006801:Humans; D051379:Mice; D014157:Transcription Factors / Q000378:metabolism; D015262:Xenobiotics / Q000378:metabolism* / Q000633:toxicity
D014157:Transcription Factors; D015262:Xenobiotics