title: Novel fabrication of a polymer scaffold with a dense bioactive ceramic coating layer.
abstract: A novel method of coating a polymeric scaffold with a dense ceramic layer was developed. This method exploits the fact that only one of the two interlaced 3-D channels formed in a ceramic dual-scaffold can be infiltrated with a polymer. Firstly, a 3-D graphite network prepared by the rapid prototyping (RP) method was dip-coated with hydroxyapatite (HA) slurry, followed by heat-treatment at 1250 degrees C for 3 h in air. This created an additional 3-D channel through the removal of the graphite network, while preserving the pre-existing 3-D channel. Thereafter, only one channel was infiltrated with a molten poly(epsilon-caprolactone) (PCL) polymer at 140 degrees C for 12 h, producing a PCL scaffold with a dense, uniform HA coating layer. The sample showed high compressive strength with ductile behavior, due to the nature of the PCL polymer, and an excellent cellular response afforded by the bioactive HA coating layer. The results indicate that this novel technique provides a highly versatile method of coating various polymeric scaffolds with bioactive layers in order to endow them with advanced functionalities.
authors: School of Materials Science and Engineering, Seoul National University, Seoul 151-742, Korea.
authors: In-Kook
authors: IK
authors: Jun
authors: Young-Hag
authors: YH
authors: Koh
authors: Su-Hee
authors: SH
authors: Lee
authors: Hyoun-Ee
authors: HE
authors: Kim
mesh_terms: D002448:Cell Adhesion / Q000502:physiology; D018929:Cell Culture Techniques / Q000379:methods; D002460:Cell Line; D002470:Cell Survival / Q000502:physiology; D002516:Ceramics / Q000737:chemistry; D020099:Coated Materials, Biocompatible / Q000138:chemical synthesis* / Q000494:pharmacology*; D003460:Crystallization / Q000379:methods; D017886:Durapatite / Q000008:administration & dosage / Q000737:chemistry*; D006801:Humans; D008422:Materials Testing; D010006:Osteoblasts / Q000166:cytology* / Q000502:physiology*; D011091:Polyesters / Q000737:chemistry*; D013499:Surface Properties; D023822:Tissue Engineering / Q000379:methods*
chemical_list: D020099:Coated Materials, Biocompatible; D011091:Polyesters; C016240:polycaprolactone; D017886:Durapatite