Effect of HLA-A2 allele disparity on clinical outcome in hematopoietic cell transplantation from unrelated donors.
Population-based differences in clinical outcome after unrelated donor hematopoietic cell transplantation suggest that the significance of human leukocyte antigen (HLA) mismatching may be related to locus-specific and allele-specific differences that distinguish ethnically diverse transplant donors and recipients. We studied the risks associated with HLA-A locus mismatching in two large transplant populations from the International Histocompatibility Working Group in hematopoietic cell transplantation data set to better understand permissible and nonpermissible HLA-A mismatches.
Morishima
Y
Y
Aichi Cancer Center, Nagoya, Japan. ymorisim@aichi-cc.jp
Kawase
T
T
Malkki
M
M
Petersdorf
E W
EW
D000483:Alleles; D001782:Blood Donors; D018572:Disease-Free Survival; D046148:Donor Selection; D014644:Genetic Variation; D006085:Graft Survival; D006086:Graft vs Host Disease / Q000209:etiology / Q000517:prevention & control; D015789:HLA-A2 Antigen / Q000235:genetics* / Q000276:immunology*; D018380:Hematopoietic Stem Cell Transplantation; D006648:Histocompatibility; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics / Q000628:therapy*; D015996:Survival Rate; D016896:Treatment Outcome
D015789:HLA-A2 Antigen