Molecular pharmacokinetics of catharanthus (vinca) alkaloids.
This review focuses on the published data regarding the molecular determinants (enzymes, transporters, orphan nuclear receptors) of Catharanthus (vinca) alkaloids pharmacokinetics in humans. The clinical impact of these determinants (drug disposition, drug-drug interactions) is also discussed.
Levêque
Dominique
D
Pharmacy-Pharmacology, Hôpital Hautepierre, Avenue Molière, 67000 Strasbourg, France.
Jehl
François
F
D018435:ATP Binding Cassette Transporter, Subfamily B / Q000378:metabolism; D030008:Catharanthus / Q000737:chemistry; D004347:Drug Interactions; D006801:Humans; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism; D014748:Vinca Alkaloids / Q000493:pharmacokinetics*
D018435:ATP Binding Cassette Transporter, Subfamily B; D018160:Receptors, Cytoplasmic and Nuclear; D014748:Vinca Alkaloids