title: Paraoxonase (PON)1 192R allele carriage is associated with reduced risk of inflammatory bowel disease.
abstract: The paraoxonase (PON) genes family maps to chromosome 7q21-q22, within a loci that also showed evidence of susceptibility genes for both Crohn's disease (CD) and ulcerative colitis (UC). In this case-control study we investigated the possible relationship between PON1 and PON2 polymorphisms and the risk of inflammatory bowel disease (IBD). PON1 192Q/R, PON1 55L/M, and PON2 311S/C polymorphisms were investigated by RFLP analysis in DNA samples from 224 patients with CD, 58 patients with UC, and 311 healthy controls. The PON1 192R allele was significantly less common among IBD Ashkenazi patients (allelic OR = 0.61, P = 0.004, 95% CI = 0.44-0.85). In agreement with the individual SNP analysis, Ashkenazi IBD patients had a higher frequency of haplotype PON1 192Q/PON1 55L/PON2 311S (26.3% vs 17.3%; P=0.003) and a lower frequency of haplotype PON1 192R/PON1 55L/PON2 311S (18.9% vs 27.7%; P=0.008). Our results suggest that in this Ashkenazi Jewish population, carriage of PON1 R192 allele may confer protection against the development of IBD.
authors: Department of Gastroenterology, Rambam Health Care Campus, Haifa, Israel.
authors: Amir
authors: A
authors: Karban
authors: Corina
authors: C
authors: Hartman
authors: Rami
authors: R
authors: Eliakim
authors: Matti
authors: M
authors: Waterman
authors: Shula
authors: S
authors: Nesher
authors: Ofra
authors: O
authors: Barnett-Griness
authors: Raanan
authors: R
authors: Shamir
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D043303:Aryldialkylphosphatase / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D004247:DNA / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007223:Infant; D015212:Inflammatory Bowel Diseases / Q000201:enzymology / Q000208:ethnology / Q000235:genetics*; D007557:Israel / Q000453:epidemiology; D007585:Jews; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D009154:Mutation; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index
chemical_list: D004247:DNA; D043303:Aryldialkylphosphatase