title: Status epilepticus triggers caspase-3 activation and necrosis in the immature rat brain.
abstract: The mode and mechanism of neuronal death induced by status epilepticus (SE) in the immature brain have not been fully characterized. In this study, we analyzed the contribution of neuronal necrosis and caspase-3 activation to CA1 damage following lithium-pilocarpine SE in P14 rat pups. By electron microscopy, many CA1 neurons displayed evidence of early necrosis 6 hours following SE, and the full ultrastructural features of necrosis at 24-72 hours. Caspase-3 was activated in injured (acidophilic) neurons 24 hours following SE, raising the possibility that they died by caspase-dependent "programmed" necrosis.
authors: Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA. jniquet@ucla.edu
authors: Jerome
authors: J
authors: Niquet
authors: Stéphane
authors: S
authors: Auvin
authors: Mark
authors: M
authors: Archie
authors: Dae-Won
authors: DW
authors: Seo
authors: Suni
authors: S
authors: Allen
authors: Raman
authors: R
authors: Sankar
authors: Claude G
authors: CG
authors: Wasterlain
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001343:Autophagy; D001921:Brain / Q000201:enzymology* / Q000473:pathology* / Q000648:ultrastructure; D053148:Caspase 3 / Q000378:metabolism*; D016923:Cell Death; D004195:Disease Models, Animal; D016291:Dizocilpine Maleate / Q000494:pharmacology; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D005260:Female; D018021:Lithium Chloride / Q000494:pharmacology; D008297:Male; D008854:Microscopy, Electron; D009336:Necrosis / Q000473:pathology; D009474:Neurons / Q000473:pathology; D010862:Pilocarpine / Q000494:pharmacology; D017966:Pyramidal Cells / Q000201:enzymology / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D013226:Status Epilepticus / Q000139:chemically induced / Q000201:enzymology* / Q000473:pathology*
chemical_list: D018691:Excitatory Amino Acid Antagonists; D010862:Pilocarpine; D016291:Dizocilpine Maleate; C505410:Casp3 protein, rat; D053148:Caspase 3; D018021:Lithium Chloride