Rubella virus-associated uveitis in a nonvaccinated child.
OBJECTIVE
To report presumed Fuchs heterochromic uveitis (FHU) associated with Rubella virus (RV)-specific intraocular antibody production in a child who was not vaccinated against rubella.


METHODS
Observational case report.


METHODS
We examined a 13-year-old boy with chronic anterior uveitis complicated by mature cataract. Two aqueous humor (AH) samples taken with an interval of four weeks were analyzed for intraocular antibody production against RV by calculation of the Goldmann-Witmer coefficient.


RESULTS
The patient showed all the clinical signs for FHU: iris atrophy, stellate keratic precipitates, and cataract. Analysis of the AH demonstrated intraocular antibody production against RV in two sequential samples.


CONCLUSIONS
The data show that RV-associated uveitis can already present during childhood. Moreover, this finding suggests that nonvaccinated children may be at risk to develop uveitis after RV infection.
Siemerink
Martin J
MJ
F. C. Donders Institute of Ophthalmology, Eijkman Winkler Center, University Medical Center Utrecht, Utrecht, The Netherlands.
Sijssens
Karen M
KM
de Groot-Mijnes
Jolanda D F
JD
de Boer
Joke H
JH
D000293:Adolescent; D000914:Antibodies, Viral / Q000032:analysis; D001082:Aqueous Humor / Q000276:immunology; D015828:Eye Infections, Viral / Q000276:immunology / Q000821:virology*; D006801:Humans; D015863:Iridocyclitis / Q000276:immunology / Q000821:virology*; D008297:Male; D012409:Rubella / Q000276:immunology / Q000821:virology*; D012411:Rubella Vaccine; D012412:Rubella virus / Q000276:immunology / Q000472:pathogenicity*
D000914:Antibodies, Viral; D012411:Rubella Vaccine