title: A case of mucosa-associated lymphoid tissue lymphoma forming multiple lymphomatous polyposis in the small intestine.
abstract: A 50-year old woman suffering from diabetes had a CT scan that revealed a diffuse thickening of small intestinal wall and swollen paraaortic lymph nodes. An esophagogastroduodenoscopy (EGD) confirmed multiple polypoid lesions in the duodenum and small intestine, and conventional histological testing revealed non-specific inflammatory changes. Further examinations including the immunohistochemical profiles of the biopsied specimens led us to diagnose the lesion as a marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue type, forming multiple lymphomatous polyposis sequentially spreading from duodenal bulb to terminal ileum. According to Lugano's classification, its staging was clinically diagnosed as stage II. Two courses of a standard CHOP (cyclophosphamide, doxorubicin hydrochloride, vincristine sulfate, and predonisolone) regimen with rituximab reduced the lesion and the patient had a almost complete response. A 5-year follow-up EGD and histological examinations detected no recurrence of the disease.
authors: Department of Gastroenterology, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka 545-8585, Japan.
authors: Naoto
authors: N
authors: Hirata
authors: Kazunari
authors: K
authors: Tominaga
authors: Kensuke
authors: K
authors: Ohta
authors: Kaori
authors: K
authors: Kadouchi
authors: Hirotoshi
authors: H
authors: Okazaki
authors: Tetsuya
authors: T
authors: Tanigawa
authors: Masatsugu
authors: M
authors: Shiba
authors: Toshio
authors: T
authors: Watanabe
authors: Yasuhiro
authors: Y
authors: Fujiwara
authors: Shiro
authors: S
authors: Nakamura
authors: Nobuhide
authors: N
authors: Oshitani
authors: Kazuhide
authors: K
authors: Higuchi
authors: Tetsuo
authors: T
authors: Arakawa
mesh_terms: D000911:Antibodies, Monoclonal / Q000008:administration & dosage; D058846:Antibodies, Monoclonal, Murine-Derived; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use; D001706:Biopsy; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D016145:Endoscopy, Digestive System; D005260:Female; D006801:Humans; D044483:Intestinal Polyposis / Q000175:diagnosis / Q000209:etiology*; D007421:Intestine, Small / Q000473:pathology*; D018442:Lymphoma, B-Cell, Marginal Zone / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D008875:Middle Aged; D011239:Prednisolone / Q000008:administration & dosage; D000069283:Rituximab; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D000069283:Rituximab; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011239:Prednisolone