How are the myocytes aggregated so as to make up the ventricular mass?
Of late, it has become fashionable in the surgical literature to describe the ventricular mass as though arranged in the form of a continuous myocardial band, which starts at the aorta and ends at the pulmonary trunk. On the basis of this concept, its supporters have produced revisionist accounts of cardiac development and ventricular function, as well as using it as the basis for proposed surgical maneuvers. They seem unaware, however, that the original concept itself has never been supported by independent anatomic studies, while, to the best of our knowledge, they have not themselves performed anatomic investigations to prove its substance. Furthermore, the current proponents of the "unique myocardial band" ignore a large body of previous anatomic study which showed that the ventricular mass is arranged in the form of a modified blood vessel, with each myocyte anchored to its neighbor within a 3-dimensional myocardial mesh, rather than being arranged in a fashion analogous to skeletal muscles, with discrete origins and insertions of myocardial bands or tracts. In this review, we summarize the evidence showing that there are no anatomic structures within the ventricular myocardium that permit it to be unraveled in systematic fashion so as to produce the purported myocardial band. We also re-visit our own previous investigations, which supported the conventional approach, namely that the myocytes are aggregated together within a supporting fibrous matrix in the form of a 3-dimensional meshwork.
Anderson
Robert H
RH
Joseph Levy Professor of Paediatric Cardiac Morphology, Cardiac Unit, Institute of Child Health, University College, London, UK. r.anderson@ich.ucl.ac.uk
Sanchez-Quintana
Damian
D
Redmann
Klaus
K
Lunkenheimer
Paul P
PP
D000818:Animals; D002449:Cell Aggregation; D006352:Heart Ventricles / Q000503:physiopathology / Q000648:ultrastructure; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000473:pathology* / Q000503:physiopathology; D017380:Hypertrophy, Right Ventricular / Q000473:pathology* / Q000503:physiopathology; D018482:Muscle, Skeletal / Q000503:physiopathology / Q000648:ultrastructure; D009130:Muscle, Smooth / Q000503:physiopathology / Q000648:ultrastructure; D009200:Myocardial Contraction; D009206:Myocardium / Q000166:cytology* / Q000648:ultrastructure; D032383:Myocytes, Cardiac; D016276:Ventricular Function