[Comparison of preparing two polylactide nanoparticles loaded lipophilic anti-cancer herb drug by nanoprecipitation method].
This paper introduced an experimental study of polylacticacid (PLA) nanoparticles of lipophilic anti-cancer herb drug using a precipitation method. Cucurbitacins (Cu) and Curcuminoids (Cur) were selected to be model drugs. They had similar solubility but their incorporation effects were significantly different: the average drug entrapment ratio, the average drug loading and the average drug recovery were 38.53%, 2.21% and 27.02% respectively; while those of Cur-PLA-NP were 94.36%, 14.35% and 91.23% respectively. To analyse the reason, drug incorporation process was investigated. By measuring solvent evaporation rate, ratio of drug PLA precipitates, drug distribution in system and entrapping ratio at different time of preparation, we found the difference of precipitation velocity of drug was the main reason. We also concluded that not all lipophilic drug can be well entrapped into PLA nanoparticle by nanoprecipitation method. The drug incorporation depended on the interations among drug, PLA and organic solvents, in addition to the solubility of the drug.
Zhang
Ji-Fen
JF
School of Pharmacy, Southwest University, Chongqing 400715, China. zhjf@swu.edu.cn
Hou
Shi-Xiang
SX
Liu
Hui-Lian
HL
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry*; D011232:Chemical Precipitation; D054728:Cucurbitacins / Q000737:chemistry*; D003474:Curcumin / Q000737:chemistry; D004339:Drug Compounding / Q000379:methods*; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D019344:Lactic Acid / Q000737:chemistry*; D053758:Nanoparticles; D036103:Nanotechnology / Q000379:methods; D010316:Particle Size; D011091:Polyesters; D011108:Polymers / Q000737:chemistry*
D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D011091:Polyesters; D011108:Polymers; D019344:Lactic Acid; C033616:poly(lactide); D054728:Cucurbitacins; D003474:Curcumin