title: Antidiarrhoeal and antimicrobial activities of Emilia coccinea (Sims) G. Don extracts.
abstract: Emilia coccinea (Sims) G. Don is reported to possess a number of medicinal properties including antidiarrhoeal and antimicrobial activities. The antidiarrhoeal effects of both methanol and aqueous extracts of the leaves of Emilia coccinea were studied in rats against castor oil-induced diarrhoea at the doses of 200, 400 and 600 mg/kg body weight. The methanol extract, and to a lesser extent the aqueous extract, significantly prolonged the time for diarrhoeal induction; it reduced the frequency of diarrhoea episodes and decreased the propulsion of charcoal meal through the gastrointestinal tract in a dose dependent manner. The aqueous extract did not have any antimicrobial activity at the tested concentration (5 mg/ml), but the methanol extract was most active on Escherichia coli. These results may support the fact that this plant is used traditionally to cure diarrhoea.
authors: Laboratory of Microbiology and Antimicrobial Substances, Department of Biochemistry, Faculty of Science, University of Dschang, P.O. Box 67 Dschang, Cameroon.
authors: Gerald Ngo
authors: GN
authors: Teke
authors: Jules Roger
authors: JR
authors: Kuiate
authors: Omer Bébe
authors: OB
authors: Ngouateu
authors: Donatien
authors: D
authors: Gatsing
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology*; D000930:Antidiarrheals / Q000494:pharmacology*; D019659:Asteraceae / Q000737:chemistry*; D001285:Atropine / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects / Q000254:growth & development; D002368:Castor Oil; D002606:Charcoal; D003672:Defecation / Q000187:drug effects; D003967:Diarrhea / Q000139:chemically induced / Q000188:drug therapy; D004058:Diffusion; D005260:Female; D005658:Fungi / Q000187:drug effects / Q000254:growth & development; D005769:Gastrointestinal Motility / Q000187:drug effects; D008297:Male; D008826:Microbial Sensitivity Tests; D018727:Muscarinic Antagonists / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000890:Anti-Infective Agents; D000930:Antidiarrheals; D018727:Muscarinic Antagonists; D010936:Plant Extracts; D002606:Charcoal; D001285:Atropine; D002368:Castor Oil