Three cases of toxic skin eruptions associated with methotrexate and a compilation of methotrexate-induced skin eruptions.
Methotrexate is an antimetabolite used as a treatment for a variety of neoplastic and inflammatory diseases. It has a variety of cutaneous side effects, in particular when administered in high doses. This is a report of cutaneous eruptions in three patients treated with methotrexate and a review of eruptions linked to methotrexate.
Scheinfeld
Noah
N
Dept of Dermatology, St Lukes Roosevelt Hospital Center, New York, NY, USA. Scheinfeld@earthlink.net
D000020:Abortifacient Agents, Nonsteroidal / Q000009:adverse effects*; D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects*; D002051:Burkitt Lymphoma / Q000188:drug therapy / Q000453:epidemiology; D002822:Choriocarcinoma / Q000188:drug therapy; D003875:Drug Eruptions / Q000188:drug therapy / Q000209:etiology*; D005260:Female; D015658:HIV Infections / Q000453:epidemiology; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000009:adverse effects*; D008875:Middle Aged; D011247:Pregnancy; D014594:Uterine Neoplasms / Q000188:drug therapy
D000020:Abortifacient Agents, Nonsteroidal; D000970:Antineoplastic Agents; D008727:Methotrexate