title: Production and fungitoxic activity of Sch 642305, a secondary metabolite of Penicillium canescens.
abstract: Production of fungitoxic extrolites was evaluated in culture filtrates of several isolates belonging to Penicillium canescens and P. janczewskii that showed some extent of inhibitory activity against the plant pathogenic fungus Rhizoctonia solani. In addition to griseofulvin and dechlorogriseofulvin that are already known in these species, curvulinic acid, previously unreported in Penicillium, was produced by all isolates assayed. Another extrolite recently characterized from a P. verrucosum strain by the name of Sch 642305 was detected in 5 isolates of P. canescens only. The purified compound completely inhibited mycelial growth of isolates of Rhizoctonia solani and other plant pathogenic fungi in vitro. The role of this extrolite as a possible biochemical determinant of antagonism toward plant pathogenic fungi, and implications concerning chemotaxonomy are discussed.
authors: C.R.A. - Tobacco Experiment Institute, Via Vitiello 108, Scafati, Italy. rosario.nicoletti@entecra.it
authors: Rosario
authors: R
authors: Nicoletti
authors: Maria Pilar
authors: MP
authors: Lopez-Gresa
authors: Emiliano
authors: E
authors: Manzo
authors: Angela
authors: A
authors: Carella
authors: Maria Letizia
authors: ML
authors: Ciavatta
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism* / Q000494:pharmacology*; D002855:Chromatography, Thin Layer; D018942:Macrolides / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010407:Penicillium / Q000302:isolation & purification / Q000378:metabolism*; D010935:Plant Diseases / Q000382:microbiology; D012232:Rhizoctonia / Q000187:drug effects / Q000472:pathogenicity; D012988:Soil Microbiology
chemical_list: D000935:Antifungal Agents; D018942:Macrolides; C482741:Sch 642305