Reconstruction of bone fenestration on mandiblar by the guided bone regeneration methods with beta-TCP/PLGC membranes.
Guided Bone Regeneration (GBR) is a method for bone tissue regeneration. In this method, membranes are used to cover bone defects and to block the invasion of the surrounding soft tissues. It would provide sufficient time for the osteogenic cells from bone marrow to proliferate and form new bony tissues. In spite of the potential usefulness of this method, no appropriate materials for the GBR membrane have been developed. Here we design the ideal mechanical properties of the GBR membranes and created novel materials, which is the composite of beta-tricalcium phosphate (beta-TCP) and block copolymer of L-lactide, glycolide, and epsilon-caplolactone (PLGC). In the animal experiments with the use of the GBR membranes for large bone defects, we observed significant enhancement in the bone regeneration after 12 weeks implantation and proved the effectiveness of the materials.
Koyama
Yoshihisa
Y
Department of Biodesign, Tokyo Medical and Dental University, 2-3-10 Kandasurugadai, Chiyoda, Tokyo 1010062, Japan.
Kikuchi
Masanori
M
Edamura
Kazuya
K
Nagaoka
Katsuyoshi
K
Tanaka
Shigeo
S
Tanaka
Junzo
J
Takakuda
Kazuo
K
D000818:Animals; D001696:Biomechanical Phenomena; D001861:Bone Regeneration; D004285:Dogs; D048091:Guided Tissue Regeneration / Q000379:methods*; D008297:Male; D008334:Mandible / Q000502:physiology / Q000601:surgery; D008422:Materials Testing; D008567:Membranes, Artificial; D036103:Nanotechnology; D011091:Polyesters / Q000737:chemistry*
D008567:Membranes, Artificial; D011091:Polyesters; C507868:poly(glycolide-co-lactide-co-caprolactone)