title: Early postnatal iron repletion overcomes lasting effects of gestational iron deficiency in rats.
abstract: Iron deficiency anemia in early childhood causes developmental delays and, very likely, irreversible alterations in neurological functioning. One primary goal for the present study was to determine whether the effects of late gestational iron deficiency on brain monoamine metabolism, iron content, and behavioral phenotypes could be repaired with iron intervention in early lactation. Young pregnant rats were provided iron-deficient or control diets from mid-gestation (G15). At postnatal d 4 (P4), pups from iron-deficient dams were out-fostered either to other ID dams or control dams while pups of control dams were similarly fostered to other control dams. Dietary treatments continued to adulthood (P65) when brain iron and regional monoamines were evaluated. P4 iron repletion normalized body iron status, brain iron concentrations, monoamine concentrations, and monoamine transporter and receptor densities in most brain regions. Dopamine transporter densities in caudate and substantia nigra were lower in ID rats but were normalized with iron repletion. Serotonin transporter levels in most brain regions and open-field exploration were also normalized with iron repletion. The success of this approach of early postnatal iron intervention following iron deficiency in utero contrasts to a relative lack of success when the intervention is performed at weaning. These data suggest that a window of opportunity exists for reversing the detrimental effects of iron deficiency in utero in rats and provides strong support of intervention approaches in humans with iron deficiency during pregnancy.
authors: Department of Nutritional Sciences, Pennsylvania State University, University Park, PA 16802, USA. jbeard@psu.edu
authors: John L
authors: JL
authors: Beard
authors: Erica L
authors: EL
authors: Unger
authors: Laura E
authors: LE
authors: Bianco
authors: Tessy
authors: T
authors: Paul
authors: Sarah E
authors: SE
authors: Rundle
authors: Byron C
authors: BC
authors: Jones
mesh_terms: D000375:Aging / Q000378:metabolism; D018798:Anemia, Iron-Deficiency / Q000097:blood / Q000378:metabolism; D000818:Animals; D000831:Animals, Newborn; D001522:Behavior, Animal; D015306:Biogenic Monoamines / Q000378:metabolism; D001921:Brain / Q000378:metabolism; D003677:Deficiency Diseases / Q000178:diet therapy* / Q000196:embryology* / Q000378:metabolism / Q000523:psychology; D050483:Dopamine Plasma Membrane Transport Proteins / Q000378:metabolism; D005106:Exploratory Behavior; D005260:Female; D005293:Ferritins / Q000378:metabolism; D007501:Iron / Q000008:administration & dosage* / Q000378:metabolism; D000090463:Iron Deficiencies; D009043:Motor Activity; D011247:Pregnancy; D051381:Rats; D017207:Rats, Sprague-Dawley; D050486:Serotonin Plasma Membrane Transport Proteins / Q000378:metabolism; D014018:Tissue Distribution; D014168:Transferrin / Q000378:metabolism
chemical_list: D015306:Biogenic Monoamines; D050483:Dopamine Plasma Membrane Transport Proteins; D050486:Serotonin Plasma Membrane Transport Proteins; D014168:Transferrin; D005293:Ferritins; D007501:Iron