Elloxazinones A and B, New Aminophenoxazinones from Streptomyces griseus Acta 2871.
Two new aminophenoxazinone compounds with antitumor activity, elloxazinone A and B, were isolated from the culture filtrate of Streptomyces griseus Acta 2871. Their chemical structures were determined by mass spectrometry, NMR spectroscopy and X-ray analysis. Elloxazinones A and B showed a moderate inhibition of the proliferation of human cells from gastric adenocarcinoma in vitro but a strong inhibition of hepatocellular carcinoma cells whereas elloxazinone B strongly inhibited the proliferation of human breast carcinoma cells.
Graf
Ellen
E
Institut für Chemie, Technische Universität Berlin.
Schneider
Kathrin
K
Nicholson
Graeme
G
Ströbele
Markus
M
Jones
Amanda L
AL
Goodfellow
Michael
M
Beil
Winfried
W
Süssmuth
Roderich D
RD
Fiedler
Hans-Peter
HP
D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002453:Cell Cycle / Q000187:drug effects; D045744:Cell Line, Tumor; D005285:Fermentation; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D010078:Oxazines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013305:Streptomyces griseus / Q000145:classification / Q000378:metabolism*; D013329:Structure-Activity Relationship
D000903:Antibiotics, Antineoplastic; D010078:Oxazines; C521436:elloxazinone A; C521437:elloxazinone B