Building better mouse models of asthma.
Allergic asthma is a complex disease that has been modeled extensively in small rodents. Airway eosinophilia and changes in lung function have been documented using a variety of protocols. However, recent efforts have improved these models by trying to replicate the structural remodeling that occurs in the lung as a consequence of chronic allergen-driven inflammation. This review documents the recent developments in protocols and systems designed to examine pathways leading to allergen-induced airway remodeling.
Lloyd
Clare M
CM
Leukocyte Biology Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College, London SW7 2AZ, England. c.lloyd@imperial.ac.uk
D000485:Allergens; D000818:Animals; D001249:Asthma; D001985:Bronchial Provocation Tests; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic
D000485:Allergens