Sir2 deacetylases exhibit nucleophilic participation of acetyl-lysine in NAD+ cleavage.
Smith
Brian C
BC
Department of Biomolecular Chemistry, University of Wisconsin-Madison, 1300 University Avenue, Madison, Wisconsin 53706, USA.
Denu
John M
JM
D006868:Hydrolysis; D007700:Kinetics; D008239:Lysine / Q000031:analogs & derivatives / Q000378:metabolism*; D009243:NAD / Q000378:metabolism*; D037761:Sirtuins / Q000378:metabolism*
D009243:NAD; D037761:Sirtuins; D008239:Lysine