Functions of HLA-G in the immune system.
Human leukocyte antigen (HLA)-G is a nonclassical HLA class I molecule that has tolerogenic functions and acts on cells of both innate and adaptive immunity. The molecular mechanism leading to tolerance involves the interaction between HLA-G and inhibitory receptors that are expressed at the surface of immune cells. In this review, we will briefly summarize the key advances on the relationships between HLA-G and the immune system and their consequences in pathology.
Favier
B
B
Service de Recherches en Hemato-Immunologie, Direction des Sciences du Vivant, Departement de Recherche Medicale, Commissariat a l'Energie Atomique, Institut Universitaire d'Hematologie, Hopital Saint-Louis, Paris, France.
LeMaoult
J
J
Carosella
E D
ED
D006680:HLA Antigens / Q000502:physiology*; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I / Q000502:physiology*; D006801:Humans; D007107:Immune System / Q000502:physiology*
D006680:HLA Antigens; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I