Angiogenesis and chronic inflammation: cause or consequence?
Evidence has been gathered regarding the association between angiogenesis and inflammation in pathological situations. These two phenomena have long been coupled together in many chronic inflammatory disorders with distinct etiopathogenic origin, including psoriasis, rheumatoid arthritis, Crohn's disease, diabetes, and cancer. Lately, this concept has further been substantiated by the finding that several previously established non-inflammatory disorders, such as osteoarthritis and obesity, display both inflammation and angiogenesis in an exacerbated manner. In addition, the interplay between inflammatory cells, endothelial cells and fibroblasts in chronic inflammation sites, together with the fact that inflammation and angiogenesis can actually be triggered by the same molecular events, further strengthen this association. Therefore, elucidating the underlying cellular and molecular mechanisms that gather together the two processes is mandatory in order to understand their synergistic effect, and to develop new therapeutic approaches for the management of these disorders that cause a great deal of discomfort, disability, and in some cases death.
Costa
Carla
C
Laboratory for Molecular Cell Biology, Faculty of Medicine of the University of Porto, Al. Prof. Hernâni Monteiro, 4200-319, Porto, Portugal.
Incio
João
J
Soares
Raquel
R
D000818:Animals; D002908:Chronic Disease; D016207:Cytokines / Q000502:physiology; D004195:Disease Models, Animal; D006801:Humans; D007249:Inflammation / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D036341:Intercellular Signaling Peptides and Proteins / Q000502:physiology; D008954:Models, Biological; D009389:Neovascularization, Pathologic / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology
D016207:Cytokines; D036341:Intercellular Signaling Peptides and Proteins