title: Antibodies to myelin protein zero (P0) protein as markers of auto-immune inner ear diseases.
abstract: OBJECTIVE
  The inner ear can be the target of autoimmune disorders. Recognition of autoimmune inner ear disease is important, as it is one of the very few forms of sensorineural hearing loss (HL) that can be successfully treated by medical therapy. The aim of this study was to evaluate whether the detection of antibodies to myelin protein P0 (MPZ) could be a diagnostic test for inner ear disease of autoimmune cause.
  
  
  METHODS
  This multicentric prospective study included 129 patients: patients with progressive sensorineural HL or with Menière's disease, together with their control group corresponding to patients with similar symptoms, but of presumably known origin. Detection of antibodies to myelin P0 protein was performed by using western blots. NORMAL: The prevalence of antibodies to myelin P0 protein in patients with rapidly progressive HL was not statistically different from that of the control group corresponding to genetic HL patients (30 versus 28%). In patients with Menière's disease, the prevalence was lower than that of the control group corresponding to patients with benign paroxysmal positional vertigo (5.4 versus 18.7%). No patient with auto-immune disease had antibodies to myelin P0 protein.
  
  
  CONCLUSIONS
  The sole presence of antibodies to myelin P0 may not be used as a marker of inner ear disease of autoimmune origin.
authors: Département d'Immunologie Microbiologie des Pathologies Infectieuses, AP-HP, Hôpital Beaujon, Clichy, France. bnpham@ints.fr
authors: Bach-Nga
authors: BN
authors: Pham
authors: Milan
authors: M
authors: Rudic
authors: Didier
authors: D
authors: Bouccara
authors: Olivier
authors: O
authors: Sterkers
authors: Nadia
authors: N
authors: Belmatoug
authors: Jean-Pierre
authors: JP
authors: Bébéar
authors: Vincent
authors: V
authors: Couloigner
authors: Bernard
authors: B
authors: Fraysse
authors: André
authors: A
authors: Gentine
authors: Eugène
authors: E
authors: Ionescu
authors: Alain
authors: A
authors: Robier
authors: Jean-Pierre
authors: JP
authors: Sauvage
authors: Eric
authors: E
authors: Truy
authors: Thierry
authors: T
authors: Van Den Abbeele
authors: Evelyne
authors: E
authors: Ferrary
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001323:Autoantibodies / Q000096:biosynthesis / Q000097:blood*; D020274:Autoimmune Diseases of the Nervous System / Q000097:blood / Q000276:immunology*; D015415:Biomarkers / Q000097:blood; D002648:Child; D002675:Child, Preschool; D004427:Ear Diseases / Q000097:blood / Q000276:immunology*; D007758:Ear, Inner / Q000276:immunology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018993:Myelin P0 Protein / Q000276:immunology*; D011446:Prospective Studies
chemical_list: D001323:Autoantibodies; D015415:Biomarkers; D018993:Myelin P0 Protein