title: Adult Still's disease associated with cytomegalovirus infection.
abstract: A 77-year-old woman was admitted to our hospital complaining of high fever. The physical examination on admission indicated no abnormality. Although several antibiotics were administered, the spiking high fever was not alleviated. Two weeks after admission a macular rash appeared, and a high concentration of serum ferritin was observed. At this point, Still's disease was suspected, and the patient was referred to Nagasaki University Hospital. During the prescribed course of prednisolone, hepatic enzymes gradually increased to high titers accompanied by a positive test for cytomegalovirus (CMV) antigen. The CMV antigen disappeared after ganciclovir administration, and the concentration of serum ferritin decreased after steroid administration. In this report, we attempt to portray the relation between the pathogenesis of adult-onset Still's disease and the presence of CMV antigen.
authors: Izumikawa Hospital, 2405 Fukae-cho, Minami-shimabara, Nagasaki, 859-1504 Japan. kinichi@izumiawa.or.jp
authors: Kinichi
authors: K
authors: Izumikawa
authors: Yoshitomo
authors: Y
authors: Morinaga
authors: Akira
authors: A
authors: Kondo
authors: Kohei
authors: K
authors: Hara
authors: Koichi
authors: K
authors: Izumikawa
authors: Yoshitsugu
authors: Y
authors: Miyazaki
authors: Shigeru
authors: S
authors: Kohno
authors: Narihiko
authors: N
authors: Igari
authors: Mana
authors: M
authors: Akaboshi
authors: Jun
authors: J
authors: Kawakami
authors: Katsumi
authors: K
authors: Eguchi
mesh_terms: D000368:Aged; D000998:Antiviral Agents / Q000627:therapeutic use; D003587:Cytomegalovirus / Q000276:immunology*; D003586:Cytomegalovirus Infections / Q000150:complications* / Q000188:drug therapy; D005260:Female; D005293:Ferritins / Q000097:blood; D005334:Fever / Q000821:virology*; D015774:Ganciclovir / Q000627:therapeutic use; D006801:Humans; D016706:Still's Disease, Adult-Onset / Q000175:diagnosis / Q000821:virology*
chemical_list: D000998:Antiviral Agents; D005293:Ferritins; D015774:Ganciclovir