title: Foldamers as versatile frameworks for the design and evolution of function.
abstract: Foldamers are sequence-specific oligomers akin to peptides, proteins and oligonucleotides that fold into well-defined three-dimensional structures. They offer the chemical biologist a broad pallet of building blocks for the construction of molecules that test and extend our understanding of protein folding and function. Foldamers also provide templates for presenting complex arrays of functional groups in virtually unlimited geometrical patterns, thereby presenting attractive opportunities for the design of molecules that bind in a sequence- and structure-specific manner to oligosaccharides, nucleic acids, membranes and proteins. We summarize recent advances and highlight the future applications and challenges of this rapidly expanding field.
authors: Department of Biochemistry and Biophysics, University of Pennsylvania, School of Medicine, 422 Curie Boulevard, Philadelphia, Pennsylvania 19104-6059, USA.
authors: Catherine M
authors: CM
authors: Goodman
authors: Sungwook
authors: S
authors: Choi
authors: Scott
authors: S
authors: Shandler
authors: William F
authors: WF
authors: DeGrado
mesh_terms: D000818:Animals; D019281:Dimerization; D015195:Drug Design; D006801:Humans; D008968:Molecular Conformation; D010455:Peptides / Q000737:chemistry
chemical_list: D010455:Peptides