title: Detection of Torque teno virus in Epstein-Barr virus positive and negative lymph nodes of patients with Hodgkin lymphoma.
abstract: The age-specific incidence of Hodgkin lymphoma (HL) is bimodal with peaks occurring among young adults (15 - 34 years old) and people older than 45 years. Epstein-Barr virus (EBV) is associated with only one-third of HL cases. This study sought to determine if Torque teno virus (TTV) might be independently associated with HL. The presence of EBV was appraised by in situ hybridization and immunohistochemistry in lymph node biopsies from 46 patients (3 - 81 years old) with HL. TTV DNA was assessed by PCR amplification. EBV was detected in 22 (48%) patients. TTV DNA was detected in 24/46 (52%) patients, as well as in 12/20 (60%) control patients with lymphoid unspecific hyperplasia. TTV DNA was not significantly more frequent in EBV negative (54%) than in EBV positive (50%) nodes. However, it was observed that the group of young adults (15 - 34 years, n = 19) showed the lowest EBV frequency (21%) but the highest TTV occurrence (60%). This may suggest an involvement of TTV infection in the pathogenesis of HL in young adults. Further large population-based studies are required to confirm our findings.
authors: Serviço de Anatomia Patológica, Hospital Universitário, Universidade Federal de Santa Catarina, Florianópolis, Brazil.
authors: Claudia P
authors: CP
authors: Figueiredo
authors: Helena C F
authors: HC
authors: Franz-Vasconcelos
authors: Gabriella di
authors: Gd
authors: Giunta
authors: Tania L
authors: TL
authors: Mazzuco
authors: Thiago
authors: T
authors: Caon
authors: André L M
authors: AL
authors: Fernandes
authors: Cláudia M O
authors: CM
authors: Simões
authors: Victor L S
authors: VL
authors: Antunes
authors: Christian
authors: C
authors: Niel
authors: Célia R M
authors: CR
authors: Barardi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D004266:DNA Virus Infections / Q000150:complications*; D020031:Epstein-Barr Virus Infections / Q000150:complications*; D005260:Female; D004854:Herpesvirus 4, Human / Q000378:metabolism*; D006689:Hodgkin Disease / Q000473:pathology* / Q000821:virology*; D006801:Humans; D008198:Lymph Nodes / Q000821:virology*; D008297:Male; D008875:Middle Aged; D022783:Torque teno virus / Q000378:metabolism*