Tandem gold(I)-catalyzed cyclization/electrophilic cyclopropanation of vinyl allenes.
We have developed an expedient method for the synthesis of polycyclic compounds from propargyl acetates or vinyl allenes involving up to three Au(I)-catalyzed elemental steps: 3,3-rearrangement, metalla-Nazarov reaction, and electrophilic cyclopropanation. The reaction proceeds under very mild conditions and in short times. The mechanism has been studied by DFT computations.
Lemière
Gilles
G
Université Pierre et Marie Curie-Paris 6, Laboratoire de Chimie Organique (UMR CNRS 7611), Institut de Chimie Moléculaire (FR 2769), 75252 Paris cedex 05, France.
Gandon
Vincent
V
Cariou
Kevin
K
Fukuyama
Takahide
T
Dhimane
Anne-Lise
AL
Fensterbank
Louis
L
Malacria
Max
M