title: [A clinical study on combined serum hepatic fibrosis-related markers and ultrasound parameters to diagnose hepatic fibrosis].
abstract: OBJECTIVE
  This study attempted to explore the value of combining serum hepatic fibrosis-related markers and ultrasound parameters together on diagnosis of hepatic fibrosis.
  
  
  METHODS
  Six serum markers and 8 ultrasound parameters were measured from 100 patients with chronic hepatitis B or cirrhosis. The results of the serum hepatic fibrosis-related markers and ultrasound in disease group were analyzed and compared with the findings of hepatic pathology.
  
  
  RESULTS
  By filtrating,the group of platelet derived growth factor-BB (PDGF-BB) plus hyaluronic acid (HA) plus echo characteristics of liver parenchyma (LPEC) plus length of spleen (SL) had the highest Se and Spe, which were 90.7% and 85.4% respectively.
  
  
  CONCLUSIONS
  The advantageous combination of serum markers and ultrasound parameters can significantly improve Se and Spe, which is superior to any single serum index or ultrasound parameter. And it was a better non-invasive method for diagnosing hepatic fibrosis.
authors: Department of the Second Internal Medicine, Henan Provincial People's Hospital, Zhengzhou 450003, China.
authors: Jing
authors: J
authors: Yu
authors: Chang-he
authors: CH
authors: Jia
authors: Qi
authors: Q
authors: Wang
authors: Po-shi
authors: PS
authors: Xu
authors: Hao
authors: H
authors: Zhang
authors: Yu-qin
authors: YQ
authors: Zhao
authors: Quan
authors: Q
authors: Shen
authors: Yan-rui
authors: YR
authors: Hao
authors: Gui-fen
authors: GF
authors: Cai
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000410:Alanine Transaminase / Q000097:blood; D000077214:Becaplermin; D015415:Biomarkers / Q000097:blood*; D024061:Collagen Type III / Q000097:blood; D005260:Female; D019694:Hepatitis B, Chronic / Q000097:blood / Q000175:diagnosis* / Q000000981:diagnostic imaging; D006801:Humans; D006820:Hyaluronic Acid / Q000097:blood; D008103:Liver Cirrhosis / Q000097:blood / Q000175:diagnosis* / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D010982:Platelet-Derived Growth Factor / Q000032:analysis; D020574:Proto-Oncogene Proteins c-sis; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D019715:Tissue Inhibitor of Metalloproteinase-1 / Q000097:blood; D016212:Transforming Growth Factor beta / Q000097:blood; D018615:Ultrasonography, Doppler, Color / Q000379:methods*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D024061:Collagen Type III; D010982:Platelet-Derived Growth Factor; D020574:Proto-Oncogene Proteins c-sis; D019715:Tissue Inhibitor of Metalloproteinase-1; D016212:Transforming Growth Factor beta; D000077214:Becaplermin; D006820:Hyaluronic Acid; D000410:Alanine Transaminase