Fetal and maternal vascular lesions.
Many commonly diagnosed disorders of the placenta relate to maternal and fetal blood flow and are thus common in the placentas of infants with adverse perinatal outcomes. Severe uteroplacental vascular disease may lead to extensive placental infarction and villous changes of reduced uteroplacental blood flow, a morphologic feature commonly associated with intrauterine growth restriction and fetal demise. Lesser degrees of villous change are seen in many infants with premature delivery, term, and multiple births resulting in admission to the neonatal intensive care units. Fetal vascular lesions including chorangiosis and fetal thrombotic vasculopathy are two processes that appear to be associated with increased risk of poor outcome.
Kaplan
Cynthia G
CG
Department of Pathology, University Hospital, Pathology Laboratories, Level II, SUNY 7025, SUNY Stony Brook, Stony Brook, NY 11790-7025, USA. ckaplan@notes.cc.sunysb.edu
D000328:Adult; D001808:Blood Vessels / Q000473:pathology; D005260:Female; D005315:Fetal Diseases / Q000209:etiology / Q000473:pathology*; D005333:Fetus / Q000098:blood supply / Q000473:pathology*; D006801:Humans; D007238:Infarction / Q000473:pathology; D010920:Placenta / Q000098:blood supply / Q000473:pathology*; D010927:Placental Insufficiency / Q000473:pathology*; D011247:Pregnancy; D011248:Pregnancy Complications; D014652:Vascular Diseases / Q000150:complications / Q000473:pathology*