[Structure-based design and biosynthesis of collagen proteins].
Collagen is the most abundant protein in human body and a periodic helix, i. e. , triple helix, fibrous protein, which provides the scaffold structures for the cell adhesion and macromolecule aggregation, etc. With the development of gene engineering and biomaterial technologies, and the incessant studies on the technique to obtain the proteins with special functions, the collagen protein has been one of the third generation biomaterials that attract more attention than others. In this paper, we reviewed the recent structure-based design and biosynthesis of collagen.
Du
Chun-Ling
CL
The Key Laboratory of Advanced Textile Materials and Manufacturing Technology of Ministry of Education, Collage of Materials and Textile, Zhejiang Sci- Tech University, Hangzhou 310018, China.
Yao
Ju-Ming
JM
D000818:Animals; D001709:Biotechnology / Q000379:methods; D003094:Collagen / Q000096:biosynthesis* / Q000737:chemistry* / Q000235:genetics; D006801:Humans; D008954:Models, Biological; D008958:Models, Molecular; D011487:Protein Conformation; D055550:Protein Stability; D017433:Protein Structure, Secondary; D013696:Temperature
D003094:Collagen