title: Slowly progressive distal muscular atrophy of the bilateral upper limbs (O'Sullivan-McLeod syndrome) partially alleviated by intravenous immunoglobulin therapy.
abstract: We report a case of O'Sullivan-McLeod syndrome in a 59-year-old man, who had experienced slowly progressive weakening of both hands since he was 20 years of age. Mild hyperIgEemia and eosinophilia were present. Nerve conduction studies revealed reduced F wave-evoked frequencies for the median and ulnar nerves. Intravenous immunoglobulin (IVIG) at a dose of 400 mg/kg/day was given for 5 days. After IVIG, the muscle weakness of the distal upper extremities improved together with increased F wave-evoked frequencies. These effects lasted for a few months. These observations suggest that immune-mediated neural damage partially contributes to O'Sullivan-McLeod syndrome.
authors: Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka.
authors: Yuji
authors: Y
authors: Kawano
authors: Yuko
authors: Y
authors: Nagara
authors: Hiroyuki
authors: H
authors: Murai
authors: Hitoshi
authors: H
authors: Kikuchi
authors: Yasumasa
authors: Y
authors: Ohyagi
authors: Jun-ichi
authors: J
authors: Kira
mesh_terms: D001132:Arm / Q000000981:diagnostic imaging*; D018450:Disease Progression; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009133:Muscular Atrophy / Q000000981:diagnostic imaging* / Q000188:drug therapy*; D011859:Radiography; D013577:Syndrome
chemical_list: D016756:Immunoglobulins, Intravenous