title: Loss-of-function alleles of the JIL-1 histone H3S10 kinase enhance position-effect variegation at pericentric sites in Drosophila heterochromatin.
abstract: In this study we show that loss-of-function alleles of the JIL-1 histone H3S10 kinase act as enhancers of position-effect variegation at pericentric sites whereas the gain-of-function JIL-1(Su(var)3-1[3]) allele acts as a suppressor strongly supporting a functional role for JIL-1 in maintaining euchromatic chromatin and counteracting heterochromatic spreading and gene silencing.
authors: Department of Biochemistry, Biophysics, and Molecular Biology Iowa State University Ames, Iowa 50011, USA.
authors: Xiaomin
authors: X
authors: Bao
authors: Huai
authors: H
authors: Deng
authors: Jørgen
authors: J
authors: Johansen
authors: Jack
authors: J
authors: Girton
authors: Kristen M
authors: KM
authors: Johansen
mesh_terms: D000818:Animals; D002843:Chromatin / Q000235:genetics; D002874:Chromosome Mapping; D004247:DNA / Q000235:genetics*; D004330:Drosophila / Q000235:genetics*; D029721:Drosophila Proteins / Q000235:genetics*; D020868:Gene Silencing; D017930:Genes, Reporter; D006570:Heterochromatin / Q000235:genetics*; D019656:Loss of Heterozygosity / Q000235:genetics*; D017346:Protein Serine-Threonine Kinases / Q000235:genetics*; D017384:Sequence Deletion
chemical_list: D002843:Chromatin; D029721:Drosophila Proteins; D006570:Heterochromatin; D004247:DNA; C507306:JIL-1 protein, Drosophila; D017346:Protein Serine-Threonine Kinases