Antielastin autoimmunity in tobacco smoking-induced emphysema.
Chronic obstructive pulmonary disease and emphysema are common destructive inflammatory diseases that are leading causes of death worldwide. Here we show that emphysema is an autoimmune disease characterized by the presence of antielastin antibody and T-helper type 1 (T(H)1) responses, which correlate with emphysema severity. These findings link emphysema to adaptive immunity against a specific lung antigen and suggest the potential for autoimmune pathology of other elastin-rich tissues such as the arteries and skin of smokers.
Lee
Seung-Hyo
SH
Department of Medicine, Section of Pulmonary and Critical Care, Baylor College of Medicine, Houston, Texas 77030, USA.
Goswami
Sangeeta
S
Grudo
Ariel
A
Song
Li-Zhen
LZ
Bandi
Venkata
V
Goodnight-White
Sheila
S
Green
Linda
L
Hacken-Bitar
Joan
J
Huh
Joseph
J
Bakaeen
Faisal
F
Coxson
Harvey O
HO
Cogswell
Sebastian
S
Storness-Bliss
Claudine
C
Corry
David B
DB
Kheradmand
Farrah
F
D015551:Autoimmunity; D001402:B-Lymphocytes / Q000276:immunology; D004549:Elastin / Q000276:immunology*; D004646:Emphysema / Q000209:etiology* / Q000276:immunology*; D006801:Humans; D008168:Lung; D029424:Pulmonary Disease, Chronic Obstructive / Q000209:etiology / Q000276:immunology; D012907:Smoking / Q000009:adverse effects* / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D004549:Elastin