Pt(II)-catalyzed synthesis of 1,2-dihydropyridines from aziridinyl propargylic esters.
Pt(II)-catalyzed cycloisomerization of aziridinyl propargylic esters affords 1,2-dihydropyridines with regiodefined installation of substituents. A mild conversion of the 1,2-dihydropyridines to the corresponding substituted pyridines as well as chirality retention from the aziridinyl propargylic ester substrates have been demonstrated.
Motamed
Massoud
M
Department of Chemistry, University of California, Berkeley, California 94720, USA.
Bunnelle
Eric M
EM
Singaram
Surendra W
SW
Sarpong
Richmond
R
D002384:Catalysis; D004095:Dihydropyridines / Q000138:chemical synthesis*; D008958:Models, Molecular; D015394:Molecular Structure; D010984:Platinum / Q000737:chemistry*
D004095:Dihydropyridines; D010984:Platinum