Review. Comparison of multidrug resistant efflux pumps of cancer and bacterial cells with respect to the same inhibitory agents.
Bacteria and cancer cells develop resistance to more than one agent as a consequence of being exposed to ineffective levels of the agent for a prolonged period of time. The resistance of these cells is mediated by over-expressed efflux pumps that have the ability to extrude a large variety of unrelated chemicals. This review discusses the main types of multidrug resistant (MDR) efflux systems of bacteria and cancer cells, and shows the similarity of specific efflux systems between them with respect to given agents that inhibit efflux, thus rendering these cells once more susceptible to agents to which they had developed MDR.
Amaral
Leonard
L
Unit of Mycobacteriology, UPMM, Institute of Hygiene and Tropical Medicine, Universidade Nova de Lisboa, 1349-088 Lisboa, Portugal. lamaral@ihmt.unl.pt
Engi
Helga
H
Viveiros
Miguel
M
Molnar
Joseph
J
D018528:ATP-Binding Cassette Transporters / Q000378:metabolism*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D018407:Bacterial Physiological Phenomena; D045744:Cell Line, Tumor; D024881:Drug Resistance, Bacterial; D018432:Drug Resistance, Multiple; D019008:Drug Resistance, Neoplasm; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology*
D018528:ATP-Binding Cassette Transporters; D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents