An unusual association of a sellar gangliocytoma with a prolactinoma.
The simultaneous occurrence of a hypothalamic and sellar gangliocytoma with a pituitary prolactinoma is very rare. The explanation for such an association is not known. We describe the case of a woman who had a coexisting adjacent pituitary prolactinoma and gangliocytoma within the same sellar mass. The tumor cells of the gangliocytoma demonstrated expression of enkephalin, a product of proopiomelanocortin known to be a prolactin secretagogue. We postulate that in this patient there may be a link between gangliocytoma enkephalin and prolactin hypersecretion.
Serri
Omar
O
Departments of Medicine, Radiology and Pathology, CHUM Notre-Dame Hospital, University of Montreal, 1560 Sherbrooke East, Montreal, QC H2L 4M1, Canada. omar.serri@umontreal.ca
Berthelet
France
F
Bélair
Manon
M
Vallette
Sophie
S
Asa
Sylvia L
SL
D017024:Chemotherapy, Adjuvant; D018491:Dopamine Agonists / Q000627:therapeutic use; D004745:Enkephalins / Q000378:metabolism; D005260:Female; D005729:Ganglioneuroma / Q000378:metabolism / Q000473:pathology* / Q000628:therapy; D020249:Hormone Replacement Therapy; D006801:Humans; D007029:Hypothalamic Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000628:therapy; D008279:Magnetic Resonance Imaging; D009378:Neoplasms, Multiple Primary; D019635:Neurosurgical Procedures; D010911:Pituitary Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000628:therapy; D011388:Prolactin / Q000378:metabolism; D015175:Prolactinoma / Q000378:metabolism / Q000473:pathology* / Q000628:therapy; D012658:Sella Turcica / Q000473:pathology*; D012888:Skull Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000628:therapy; D016896:Treatment Outcome; D055815:Young Adult
D018491:Dopamine Agonists; D004745:Enkephalins; D011388:Prolactin