title: Catalytic asymmetric hydrogenation of aldehydes.
abstract: Racemic alpha-arylaldehydes provide the corresponding primary alcohols via dynamic kinetic resolution in excellent enantioselectivities and yields upon hydrogenation using a Noyori ruthenium catalyst; for example, the biologically active (S)-enantiomer of the non-steroidal anti-inflammatory drug ibuprofen could be synthesized via catalytic enantioselective hydrogenation of aldehyde followed by oxidation with potassium permanganate in 76% isolated yield and 96 : 4 er.
authors: Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470 Mülheim an der Ruhr, Germany.
authors: Xiaoguang
authors: X
authors: Li
authors: Benjamin
authors: B
authors: List
mesh_terms: D000447:Aldehydes / Q000138:chemical synthesis / Q000737:chemistry*; D002384:Catalysis; D006859:Hydrogen / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D006859:Hydrogen