title: Piperidine amides as 11beta-hydroxysteroid dehydrogenase type 1 inhibitors.
abstract: A series of piperidine amide inhibitors of human 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) were identified via modifications of the HTS hit compound 1. The synthesis, in vitro biological evaluation, and structure-activity relationship of these compounds are presented.
authors: Biovitrum AB, SE-112 76 Stockholm, Sweden. katarina.flyren@biovitrum.com
authors: Katarina
authors: K
authors: Flyrén
authors: Lars O
authors: LO
authors: Bergquist
authors: Victor M
authors: VM
authors: Castro
authors: Christopher
authors: C
authors: Fotsch
authors: Lars
authors: L
authors: Johansson
authors: David J
authors: DJ
authors: St Jean
authors: Lori
authors: L
authors: Sutin
authors: Meredith
authors: M
authors: Williams
mesh_terms: D043205:11-beta-Hydroxysteroid Dehydrogenase Type 1 / Q000037:antagonists & inhibitors*; D000577:Amides / Q000737:chemistry / Q000494:pharmacology*; D001665:Binding Sites; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology*; D006801:Humans; D007124:Immunoenzyme Techniques; D008956:Models, Chemical; D010880:Piperidines / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000577:Amides; D004791:Enzyme Inhibitors; D010880:Piperidines; C032727:piperidine; D043205:11-beta-Hydroxysteroid Dehydrogenase Type 1