Systemic neurochemical alterations in schizophrenic brain: glutamate metabolism in focus.
We have used a systemic approach to establish a relationship between enzyme measures of glial glutamate and energy metabolism (glutamine synthetase and glutamine synthetase-like protein, glutamate dehydrogenase isoenzymes, brain isoform creatine phosphokinase) and two major glial proteins (glial fibrillary acidic protein and myelin basic protein) in autopsied brain samples taken from patients with schizophrenia (SCH) and mentally healthy subjects (23 and 22 cases, respectively). These biochemical parameters were measured in tissue extracts in three brain areas (prefrontal cortex, caudate nucleus, and cerebellum). Significant differences in the level of at least one of the glutamate metabolizing enzymes were observed between two studied groups in all studied brain areas. Different patterns of correlative links between the biochemical parameters were found in healthy and schizophrenic brains. These findings give a new perspective to our understanding of the impaired regulation of enzyme levels in the brain in SCH.
Burbaeva
Gulnur Sh
GSh
Laboratory of Neurochemistry, Mental Health Research Center, Russian Academy of Medical Sciences, 2-2 Zagorodnoje shosse, 117152 Moscow, Russia. burbaeva@yahoo.com
Boksha
Irina S
IS
Tereshkina
Elena B
EB
Savushkina
Olga K
OK
Starodubtseva
Lubov' I
LI
Turishcheva
Marina S
MS
Mukaetova-Ladinska
Elizabeta
E
D000328:Adult; D000367:Age Factors; D000368:Aged; D001921:Brain / Q000378:metabolism*; D002421:Caudate Nucleus / Q000378:metabolism; D002525:Cerebellar Cortex / Q000378:metabolism; D052276:Creatine Kinase, BB Form / Q000378:metabolism; D004734:Energy Metabolism / Q000502:physiology; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D018086:Glutamate Dehydrogenase (NADP+) / Q000378:metabolism; D005974:Glutamate-Ammonia Ligase / Q000378:metabolism; D018698:Glutamic Acid / Q000378:metabolism*; D006801:Humans; D008875:Middle Aged; D004676:Myelin Basic Protein / Q000378:metabolism; D017397:Prefrontal Cortex / Q000378:metabolism; D012559:Schizophrenia / Q000378:metabolism*
D005904:Glial Fibrillary Acidic Protein; D004676:Myelin Basic Protein; D018698:Glutamic Acid; D018086:Glutamate Dehydrogenase (NADP+); D052276:Creatine Kinase, BB Form; D005974:Glutamate-Ammonia Ligase