title: Outcomes in patients with an emergency department diagnosis of fever of unknown origin.
abstract: OBJECTIVE
  To describe the outcomes in patients given an ED diagnosis of fever of unknown origin (FUO).
  
  
  METHODS
  A retrospective analysis of ED records linked to hospital morbidity, mortality and microbiology records of patients presenting to Western Australia's teaching hospitals from July 2000 to July 2003.
  
  
  RESULTS
  There were 3218 presentations diagnosed with FUO, 2049 (63.7%) children (median age 1.8 years) and 1169 (36.3%) adults (median age 56.0 years). FUO accounted for 0.3% of adult and 1.5% of paediatric ED presentations. Overall, 1997 (62.1%, 95% confidence interval 60.4-63.8%) were admitted (82% adults vs 50.7% children; P < 0.001). Adults had a longer median length of stay than children (4 days vs 2 days; P < 0.001) and a higher proportion of positive blood cultures (admissions 15.1%vs 4.9%; P < 0.001) commonly with Escherichia coli. Streptococcus pneumoniae was the most common organism isolated from children. Of 3053 FUO index presentations, 338 (11.1%, 95% confidence interval 10.0-12.2%) re-presented. Children were more likely to re-present than adults (13.5% of 1959 vs 6.8% of 1094; P < 0.001).
  
  
  CONCLUSIONS
  Fever of unknown origin is diagnosed less frequently in adults than in children. Adult patients are more likely to be admitted, have longer lengths of stay and have positive blood cultures. Although FUO is diagnosed infrequently in the ED, blood cultures remain useful in the evaluation of unexplained fever, particularly in adults as age increases.
authors: Discipline of Emergency Medicine, School of Primary, Aboriginal and Rural Health Care, University of Western Australia, Australia. singarfield@meddent.uwa.edu.au
authors: Sharyn L
authors: SL
authors: Ingarfield
authors: Antonio
authors: A
authors: Celenza
authors: Ian G
authors: IG
authors: Jacobs
authors: Thomas V
authors: TV
authors: Riley
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016470:Bacteremia / Q000175:diagnosis* / Q000453:epidemiology / Q000382:microbiology; D016009:Chi-Square Distribution; D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D004636:Emergency Service, Hospital; D005260:Female; D005335:Fever of Unknown Origin / Q000175:diagnosis* / Q000453:epidemiology / Q000382:microbiology; D006801:Humans; D007223:Infant; D008297:Male; D010343:Patient Admission / Q000706:statistics & numerical data; D012189:Retrospective Studies; D018709:Statistics, Nonparametric; D014904:Western Australia / Q000453:epidemiology