title: Comparison of two doses of metformin (2.5 and 1.5 g/day) for the treatment of polycystic ovary syndrome and their effect on body mass index and waist circumference.
abstract: Fifty-six women with body mass index (BMI) greater than 27 were randomly divided into two groups receiving different doses of metformin (2.5 g and 1.5 g/day) for the treatment of polycystic ovary syndrome to assess its effects on BMI and waist circumference. Although after 6 months of treatment both groups had a significant reduction in those indices, the intergroup variation proved the higher dose to be more efficient.
authors: Instituto de Ginecologia da Universidade Federal do Rio de Janeiro, Brazil. ricardovbruno@terra.com.br <ricardovbruno@terra.com.br>
authors: Ricardo Vasconcellos
authors: RV
authors: Bruno
authors: Márcio Augusto Pinto
authors: MA
authors: de Avila
authors: Fernanda Baleeiro
authors: FB
authors: Neves
authors: Antonio Egidio
authors: AE
authors: Nardi
authors: Clícia Márcia Santos
authors: CM
authors: Crespo
authors: Antonio Tavares Carneiro
authors: AT
authors: Sobrinho
mesh_terms: D000328:Adult; D015992:Body Mass Index; D001835:Body Weight / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage; D007333:Insulin Resistance; D008687:Metformin / Q000008:administration & dosage*; D011085:Polycystic Ovary Syndrome / Q000188:drug therapy*; D049629:Waist-Hip Ratio
chemical_list: D007004:Hypoglycemic Agents; D008687:Metformin