title: A model for cell type localization in the migrating slug of Dictyostelium discoideum based on differential chemotactic sensitivity to cAMP and differential sensitivity to suppression of chemotaxis by ammonia.
abstract: The three basic cell types in the migrating slug of Dictyostelium discoideum show differential chemotactic response to cyclic AMP (cAMP) and differential sensitivity to suppression of the chemotaxis by ammonia.The values of these parameters indicate a progressive maturation of chemotactic properties during the transdifferentiation of slug cell types.We present a model that explains the localization of the three cell types within the slug based on these chemotactic differences and on the maturation of their chemotactic properties.
authors: Franklin and Marshall College, Lancaster, PA 17603, USA. ifeit@fandm.edu
authors: Ira N
authors: IN
authors: Feit
authors: Jeffrey
authors: J
authors: Pawlikowski
authors: Caroline
authors: C
authors: Zawilski
mesh_terms: D000641:Ammonia / Q000633:toxicity; D000818:Animals; D002454:Cell Differentiation / Q000502:physiology*; D002630:Chemotactic Factors / Q000378:metabolism*; D002633:Chemotaxis / Q000187:drug effects*; D000242:Cyclic AMP / Q000378:metabolism*; D004023:Dictyostelium / Q000166:cytology / Q000502:physiology*; D008954:Models, Biological
chemical_list: D002630:Chemotactic Factors; D000641:Ammonia; D000242:Cyclic AMP