title: Utility of the mean cumulative function in the analysis of fall events.
abstract: BACKGROUND
  Falls are the most common cause of injury among elderly people; half of those people fall recurrently. The objective of these simulation studies was to describe the Mean Cumulative Function (MCF) and to evaluate the utility of the MCF in detecting differences between groups experiencing different patterns of event intensities.
  
  
  METHODS
  We specified 250 participants per group with a maximum follow-up time of 365 days. A participant could experience 0, 1, 2, 3, or 4 falls. In the baseline experiment, Groups A and B had an average intensity of 60 and 90 days to the first fall event. These event intensities remained constant for events 2-4. Group C represents a short term "strong" initial impact of the intervention modeled for falls 1 and 2, with an average intensity of one fall per 117 days; however, the intervention wanes to "moderate" for falls 3 and 4 with an average intensity of one fall per 90 days. Group D represents a long-term "strong" impact of the intervention modeled by an average intensity of one fall per 117 days for all subsequent events.
  
  
  RESULTS
  The MCF was able to detect differences between groups that had varying intensities of subsequent falls. In Group A, all participants experienced at least one fall, whereas Groups B, C, and D had 4, 9, and 15 participants, respectively, who did not experience any falls. The proportion of participants who had 4 falls declined from 84% to 40% in Groups A and D, respectively. When Group A was compared to Group D, the MCF difference detected the prevention of, on average, one fall per person within 175 days. Discussion. A novel instrument for this field of clinical research--the MCF--allows investigators to compare the average number of falls per participant when the intervention reduces the intensity of subsequent falls.
authors: Department of Health Care and Epidemiology, Vancouver Coastal Health Research Institute, Vancouver, British Columbia, Canada. meghangd@interchange.ubc.ca
authors: Meghan G
authors: MG
authors: Donaldson
authors: Boris
authors: B
authors: Sobolev
authors: Lisa
authors: L
authors: Kuramoto
authors: Wendy L
authors: WL
authors: Cook
authors: Karim M
authors: KM
authors: Khan
authors: Patti A
authors: PA
authors: Janssen
mesh_terms: D000058:Accidental Falls / Q000517:prevention & control* / Q000706:statistics & numerical data*; D000368:Aged; D003198:Computer Simulation; D005500:Follow-Up Studies; D006801:Humans; D008962:Models, Theoretical; D012008:Recurrence