The GBV-C envelope glycoprotein E2 does not interact specifically with CD81.
The addition of GB virus C (GBV-C) E2 protein to cells inhibits HIV replication in vitro, presumably triggered by interactions with a specific cellular receptor. Indirect evidence suggests that CD81 is the GBV-C E2 cellular receptor. We found that E2 binding to cells was not dependent upon human CD81, and that soluble CD81 did not compete with GBV-C E2 for cell binding. GBV-C E2 protein thus does not appear to interact with CD81.
Kaufman
Thomas M
TM
Iowa City VA Medical Center and the University of Iowa, Iowa City, Iowa, USA.
McLinden
James H
JH
Xiang
Jinhua
J
Engel
Alfred M
AM
Stapleton
Jack T
JT
D000818:Animals; D015703:Antigens, CD / Q000378:metabolism*; D000956:Antigens, Viral / Q000378:metabolism; D001667:Binding, Competitive; D015496:CD4-Positive T-Lymphocytes / Q000378:metabolism*; D016466:CHO Cells; D006224:Cricetinae; D003412:Cricetulus; D029407:GB virus C / Q000276:immunology; D006801:Humans; D008562:Membrane Glycoproteins / Q000378:metabolism; D051379:Mice; D060225:Tetraspanin 28; D014759:Viral Envelope Proteins / Q000378:metabolism*
D015703:Antigens, CD; D000956:Antigens, Viral; C554798:CD81 protein, human; C554799:Cd81 protein, mouse; D008562:Membrane Glycoproteins; D060225:Tetraspanin 28; D014759:Viral Envelope Proteins; C107619:glycoprotein E2, GB virus C