title: Steady-state lopinavir levels in third trimester of pregnancy.
abstract: Stek and colleagues reported low lopinavir levels in the third trimester of pregnancy at standard dosing. Since their initial report in 2003, we have taken steady-state trough lopinavir levels in all pregnant women in the third trimester; the results of 26 women on a lopinavir/ritonavir regimen are reported. The median trough level was 3.66 microg/ml, range 0.25-9.97; the median HIV viral load was 49 copies/ml at delivery. All infants were HIV polymerase chain reaction negative at 3 months.
authors: St Thomas' Hospital, London, UK.
authors: Fiona
authors: F
authors: Lyons
authors: Martin
authors: M
authors: Lechelt
authors: Annemiek
authors: A
authors: De Ruiter
mesh_terms: D000293:Adolescent; D000328:Adult; D004338:Drug Combinations; D016903:Drug Monitoring / Q000379:methods; D005260:Female; D015658:HIV Infections / Q000097:blood* / Q000188:drug therapy / Q000821:virology; D017320:HIV Protease Inhibitors / Q000097:blood* / Q000627:therapeutic use; D015497:HIV-1; D006801:Humans; D061466:Lopinavir; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000097:blood* / Q000188:drug therapy; D011263:Pregnancy Trimester, Third; D011744:Pyrimidinones / Q000097:blood* / Q000627:therapeutic use; D019438:Ritonavir / Q000627:therapeutic use; D016896:Treatment Outcome; D019562:Viral Load
chemical_list: D004338:Drug Combinations; D017320:HIV Protease Inhibitors; D011744:Pyrimidinones; D061466:Lopinavir; D019438:Ritonavir