title: Highly efficient non-biofouling coating of zwitterionic polymers: poly((3-(methacryloylamino)propyl)-dimethyl(3-sulfopropyl)ammonium hydroxide).
abstract: This work describes the formation of highly efficient non-biofouling polymeric thin films of poly((3-(methacryloylamino)propyl)-dimethyl(3-sulfopropyl)ammonium hydroxide), (poly(MPDSAH)). The poly(MPDSAH) films were generated from the self-assembled monolayers terminating in an initiator of atom transfer radical polymerization (ATRP) by the surface-initiated ATRP of MPDSAH. The poly(MPDSAH) films on a gold surface were characterized by ellipsometry, FT-IR spectroscopy, contact angle goniometery, and X-ray photoelectron spectroscopy. The copper complexes and unpolymerized monomers trapped inside the polymer brushes were completely washed out by soaking the poly(MPDSAH)-coated substrate in water at 40 degrees C for 4 days. The amount of proteins nonspecifically adsorbed onto the poly(MPDSAH) films was evaluated by surface plasmon resonance spectroscopy: the adsorption of proteins was <0.6 ng/cm(2) on the surfaces for all the model proteins. The ability of the poly(MPDSAH) films to resist the nonspecific adsorption of proteins was comparable to that of the best known systems.
authors: Department of Chemistry and School of Molecular Science (BK21), Center for Molecular Design and Synthesis, KAIST, Daejeon 305-701, Korea.
authors: Woo Kyung
authors: WK
authors: Cho
authors: Bokyung
authors: B
authors: Kong
authors: Insung S
authors: IS
authors: Choi
mesh_terms: D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D003300:Copper / Q000737:chemistry; D006046:Gold / Q000737:chemistry*; D008567:Membranes, Artificial; D008689:Methacrylates / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D000644:Quaternary Ammonium Compounds / Q000737:chemistry*; D013052:Spectrometry, X-Ray Emission; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D020099:Coated Materials, Biocompatible; D008567:Membranes, Artificial; D008689:Methacrylates; D011108:Polymers; D000644:Quaternary Ammonium Compounds; C520687:poly((3-(methacryloylamino)propyl)-dimethyl(3-sulfopropyl)ammonium hydroxide); D006046:Gold; D003300:Copper