title: [The autoimmune features of vasculopathies].
abstract: In the development of atherosclerotic plaques we can identify three autoantigens, the pathological value of which has been proven by experimental and clinical data. These antigens are the 60 kDa heat-shock-protein, beta2-glycoprotein I and oxidized LDL. They have role in the antigen-specific T-cell differentiation processes, moreover, against these antigens autoantibodies are produced, which have prothrombotic activity, leading to the acceleration of atherosclerosis. In autoimmune diseases besides these factors other mechanisms are present, which lead to the development of autoimmune vasculopathies. The current review gives an overview of these vasculopathies.
authors: Debreceni Egyetem, Orvos- és Egészségtudományi Centrum, Belgyógyászati Intézet, III. sz. Belgyógyászati Klinika, Budapest, Hungary. soltesz@iiibel.dote.hu
authors: Pál
authors: P
authors: Soltész
authors: Zoltán
authors: Z
authors: Prohászka
authors: György
authors: G
authors: Füst
authors: Henrietta
authors: H
authors: Dér
authors: György
authors: G
authors: Kerekes
authors: Péter
authors: P
authors: Szodoray
authors: Margit
authors: M
authors: Zeher
authors: Zoltán
authors: Z
authors: Szekanecz
mesh_terms: D016736:Antiphospholipid Syndrome / Q000276:immunology; D001323:Autoantibodies / Q000097:blood*; D015551:Autoimmunity; D018834:Chaperonin 60 / Q000276:immunology; D008078:Cholesterol, LDL / Q000276:immunology; D006801:Humans; D015227:Lipid Peroxidation; D013601:T-Lymphocytes / Q000276:immunology; D014652:Vascular Diseases / Q000276:immunology*; D053482:beta 2-Glycoprotein I / Q000276:immunology
chemical_list: D001323:Autoantibodies; D018834:Chaperonin 60; D008078:Cholesterol, LDL; D053482:beta 2-Glycoprotein I