Additional scalarane sesterterpenes from the sponge Phyllospongia papyracea.
A chemical investigation of the marine sponge Phyllospongia papyracea, collected in Papua New Guinea, initiated by the screening result of a beta-catenin/Tcf4 disruption assay afforded six new bishomoscalarane sesterterpenes containing two rare scalaranes with a cyclobutane ring in the molecule, together with one known scalarane sesterterpene. The structures of the new compounds were elucidated by 1D and 2D spectroscopic techniques. The compounds isolated in this study did not show activity against the beta-catenin and Tcf4 complex.
Li
Hou-Jin
HJ
Department of Chemistry and Biochemistry and Institute for Marine Sciences, University of California Santa Cruz, Santa Cruz, California 95064, USA.
Amagata
Taro
T
Tenney
Karen
K
Crews
Phillip
P
D000818:Animals; D006801:Humans; D008386:Marine Biology; D015394:Molecular Structure; D010219:Papua New Guinea; D011161:Porifera / Q000737:chemistry*; D054830:Sesterterpenes; D051820:TCF Transcription Factors / Q000187:drug effects; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D058118:Transcription Factor 7-Like 2 Protein; D051176:beta Catenin / Q000187:drug effects
D054830:Sesterterpenes; D051820:TCF Transcription Factors; C544894:TCF7L2 protein, human; D013729:Terpenes; D058118:Transcription Factor 7-Like 2 Protein; D051176:beta Catenin