Is KPNB3 locus associated with schizophrenia?
OBJECTIVE
To reconfirm the association of KPNB3 with schizophrenia in Chinese population.


METHODS
Two single nucleotide polymorphisms (SNPs), rs2588014 and rs626716 at the KPNB3 locus, were genotyped in 304 Chinese Han family trios consisting of fathers, mothers, and affected offsprings with schizophrenia. These 2 SNPs were detected by PCR-based restriction fragment length polymorphism (RFLP) analysis. The Hardy-Weinberg equilibrium for genotypic distributions was estimated by the goodness-of-fit test. The UNPHASED program was used to perform transmission disequilibrium test (TDT), haplotype analysis, and pair-wise measure of linkage disequilibrium (LD) between these 2 SNPs.


RESULTS
The genotypic distributions of both rs2588014 and rs626716 were in the Hardy-Weinberg equilibrium (P > 0.05). The TDT revealed allelic association with rs626716 (chi2 = 9.31, P = 0.0023) but not with rs2588014 (chi2 = 3.44, P = 0.064). The global P-value was 0.0099 for 100 permutations. The haplotype analysis also showed a disease association (chi2 = 25.97, df = 3, P = 0.0000097).


CONCLUSIONS
The present study provides further evidence in support of the KPNB3 association with schizophrenia in Chinese population.
Liu
Li-Bo
LB
Research Center for Genomic Medicine, School of Public Health, Jilin University, Changchun, China.
Hu
Ying
Y
Ju
Gui-Zhi
GZ
Zhang
Xuan
X
Xie
Lin
L
Liu
Shu-Zheng
SZ
Shi
Jie-Ping
JP
Yu
Ya-Qin
YQ
Xu
Qi
Q
Fan
Yu
Y
Shen
Yan
Y
Wei
Jun
J
D000328:Adult; D002681:China / Q000453:epidemiology; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D012559:Schizophrenia / Q000453:epidemiology / Q000235:genetics*; D028961:beta Karyopherins / Q000235:genetics*
C107940:IPO5 protein, human; D028961:beta Karyopherins