Grapefruit juice, a glass full of drug interactions?
Numerous reports have documented drug interactions with grapefruit juice (GFJ) that occur via inhibition of CYP3A enzymes. As reported by Glaeser et al. in the March 2007 issue of this journal, there is increasing recognition that GFJ may also affect the activity of influx (e.g., OATPs) and efflux (e.g., P-glycoprotein) transporters. This commentary focuses on these interactions between GFJ and drug transporters.
Kirby
B J
BJ
Department of Pharmaceutics, University of Washington, Seattle, Washington, USA.
Unadkat
J D
JD
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000378:metabolism; D000818:Animals; D019540:Area Under Curve; D001628:Beverages; D002352:Carrier Proteins / Q000378:metabolism; D032083:Citrus paradisi; D065692:Cytochrome P-450 CYP3A Inhibitors; D018565:Food-Drug Interactions; D006801:Humans; D027361:Organic Anion Transporters / Q000378:metabolism
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D002352:Carrier Proteins; D065692:Cytochrome P-450 CYP3A Inhibitors; D027361:Organic Anion Transporters