Increase of renal excretion of organo-mercury compounds like methlymercury by DMPS (2,3-Dimercapto-1-propanesulfonic acid, Dimaval).
In a highly mercury-burdened, small scale gold mining area in the Philippines, spontaneous urine samples were taken from 75 Hg intoxicated volunteers before (U1), and 2-3 hours after (U2) the oral application of 200 mg DMPS (2,3-Dimercapto-1-propanesulfonic acid, Dimaval). In the urine samples, the concentrations of organic and inorganic bound mercury were determined separately by CV-AAS. In U1, median concentrations of 15.7 microg inorganic Hg/g crea. and 2.2 microg organic Hg/g crea. were found. In U2, these values increased to 262 for inorganic Hg and 14.5 for organic Hg. Maximum concentrations (microg/g crea.) as high as 7,593 for inorganic Hg and 2,011 for organic Hg were observed after DMPS. The mean (median) increasing factor (U2/U1) was 16.0 for inorganic Hg and 5.1 for organic Hg. There was a trend that females responded better to DMPS than males. It was concluded that DMPS increases the renal excretion of organic bound Hg as it does for inorganic Hg, but to a lesser extent.
Drasch
Gustav
G
Institute of Forensic Medicine, Ludwig-Maximilians-University, Munich, Germany.
Boese-O'Reilly
Stephan
S
Illig
Sven
S
D000284:Administration, Oral; D000931:Antidotes / Q000008:administration & dosage / Q000494:pharmacology*; D006046:Gold; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000378:metabolism*; D008628:Mercury / Q000145:classification / Q000652:urine; D008630:Mercury Poisoning / Q000188:drug therapy / Q000652:urine*; D008767:Methylmercury Compounds / Q000506:poisoning*; D008906:Mining; D009784:Occupational Diseases / Q000188:drug therapy / Q000652:urine*; D013054:Spectrophotometry, Atomic / Q000379:methods; D014494:Unithiol / Q000008:administration & dosage / Q000494:pharmacology*
D000931:Antidotes; D008767:Methylmercury Compounds; D014494:Unithiol; D006046:Gold; D008628:Mercury