title: Evolutionary formation of new centromeres in macaque.
abstract: A systematic fluorescence in situ hybridization comparison of macaque and human synteny organization disclosed five additional macaque evolutionary new centromeres (ENCs) for a total of nine ENCs. To understand the dynamics of ENC formation and progression, we compared the ENC of macaque chromosome 4 with the human orthologous region, at 6q24.3, that conserves the ancestral genomic organization. A 250-kilobase segment was extensively duplicated around the macaque centromere. These duplications were strictly intrachromosomal. Our results suggest that novel centromeres may trigger only local duplication activity and that the absence of genes in the seeding region may have been important in ENC maintenance and progression.
authors: Department of Genetics and Microbiology, University of Bari, 70126 Bari, Italy.
authors: Mario
authors: M
authors: Ventura
authors: Francesca
authors: F
authors: Antonacci
authors: Maria Francesca
authors: MF
authors: Cardone
authors: Roscoe
authors: R
authors: Stanyon
authors: Pietro
authors: P
authors: D'Addabbo
authors: Angelo
authors: A
authors: Cellamare
authors: L James
authors: LJ
authors: Sprague
authors: Evan E
authors: EE
authors: Eichler
authors: Nicoletta
authors: N
authors: Archidiacono
authors: Mariano
authors: M
authors: Rocchi
mesh_terms: D000818:Animals; D001483:Base Sequence; D002503:Centromere; D002896:Chromosomes, Human, Pair 6; D004247:DNA; D019143:Evolution, Molecular; D020440:Gene Duplication; D006801:Humans; D008253:Macaca mulatta / Q000235:genetics*; D008969:Molecular Sequence Data; D016324:Sequence Tagged Sites; D026801:Synteny
chemical_list: D004247:DNA