title: Metabolic correlates of brain reserve in dementia with Lewy bodies: an FDG PET study.
abstract: BACKGROUND
  Studies suggest that brain reserve allows patients with more years of schooling to cope better with brain damage. Research has been mainly focussed on Alzheimer's disease and no studies exist on patients with dementia with Lewy bodies (DLB). The aim of this study was to provide evidence for brain reserve in DLB.
  
  
  METHODS
  Twenty-one consecutive patients with DLB and 16 age-matched healthy controls were included. The participants underwent cerebral (18)F-FDG PET imaging at rest. A group comparison was conducted in SPM2 between the patient and control groups. A linear regression analysis with glucose metabolism as the dependent and years of schooling as the independent variable was performed. Age, gender and a total score of the Consortium to Establish a Registry for Alzheimer's Disease neuropsychological battery were included as covariates into the analysis.
  
  
  RESULTS
  The patients showed a significant metabolic reduction in the frontal and posterior association cortices, the basal ganglia and the pulvinar of the thalami. Glucose metabolism and education showed an inverse relationship in an extensive cluster in the left temporo-parieto-occipital cortex.
  
  
  CONCLUSIONS
  Similar findings were previously reported in Alzheimer's disease and are regarded as evidence for brain reserve. Therefore, we suggest that brain reserve is also present in DLB.
authors: Department of Psychiatry and Psychotherapy, Technical University Munich, Munich, Germany. robert.perneczky@lrz.tum.de
authors: Robert
authors: R
authors: Perneczky
authors: Peter
authors: P
authors: Haussermann
authors: Janine
authors: J
authors: Diehl-Schmid
authors: Henning
authors: H
authors: Boecker
authors: Hans
authors: H
authors: Forstl
authors: Alexander
authors: A
authors: Drzezga
authors: Alexander
authors: A
authors: Kurz
mesh_terms: D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D001921:Brain / Q000098:blood supply / Q000000981:diagnostic imaging / Q000503:physiopathology*; D001931:Brain Mapping; D016022:Case-Control Studies; D003704:Dementia / Q000150:complications / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology; D004522:Educational Status; D004734:Energy Metabolism / Q000502:physiology*; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D020961:Lewy Body Disease / Q000150:complications / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D011999:Recruitment, Neurophysiological / Q000502:physiology
chemical_list: D001786:Blood Glucose; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18