Role of tyrosine kinase-dependent phosphorylation of NR2B subunit-containing NMDA receptor in morphine reward.
We previously demonstrated that the morphine-induced rewarding effect was dramatically suppressed by cotreatment with an NR2B subunit-containing N-methyl-D-aspartate (NMDA) receptor antagonist ifenprodil. Therefore we propose here that the NR2B subunit-containing NMDA receptor may be involved in the rewarding effect of morphine. A growing body of evidence indicates that tyrosine kinases, such as Src family kinases, increase the phosphorylation of the intracellular C-terminal tyrosine residues on the NR2B subunit and potentiate NMDA receptor function. The following review provides our recent findings regarding the role of tyrosine kinase-dependent phosphorylation of the NR2B subunit-containing NMDA receptor in the development of psychological dependence on morphine.
Kato
Hideaki
H
Department of Legal Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan.
Narita
Minoru
M
Suzuki
Masami
M
Yoshimoto
Kanji
K
Yasuhara
Masahiro
M
Suzuki
Tsutomu
T
D000818:Animals; D006801:Humans; D009020:Morphine / Q000009:adverse effects*; D009714:Nucleus Accumbens / Q000502:physiology; D010446:Peptide Fragments / Q000378:metabolism / Q000502:physiology*; D010766:Phosphorylation; D011505:Protein-Tyrosine Kinases / Q000502:physiology*; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism / Q000502:physiology*; D012201:Reward; D019966:Substance-Related Disorders / Q000209:etiology*
C485096:NR2B protein (1292-1308); D010446:Peptide Fragments; D016194:Receptors, N-Methyl-D-Aspartate; D009020:Morphine; D011505:Protein-Tyrosine Kinases