Sultam thiourea inhibition of West Nile virus.
We have identified sultam thioureas as novel inhibitors of West Nile virus (WNV) replication. One such compound inhibited WNV, with a 50% effective concentration of 0.7 microM, and reduced reporter expression from cells that harbored a WNV-based replicon. Our results demonstrate that sultam thioureas can block a postentry, preassembly step of WNV replication.
Barklis
Eric
E
Vollum Institute and Department of Molecular Microbiology and Immunology, Oregon Health & Sciences University, Mail Code L220, 3181 SW Sam Jackson Park Road, Portland, OR 97201-3098, USA. barklis@ohsu.edu
Still
Amelia
A
Sabri
Mohammad I
MI
Hirsch
Alec J
AJ
Nikolich-Zugich
Janko
J
Brien
James
J
Dhenub
Tenzin Choesang
TC
Scholz
Isabel
I
Alfadhli
Ayna
A
D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D002522:Chlorocebus aethiops; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D012367:RNA, Viral / Q000187:drug effects; D012093:Replicon / Q000187:drug effects / Q000235:genetics; D013329:Structure-Activity Relationship; D013890:Thiourea / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*; D014709:Vero Cells; D014779:Virus Replication / Q000187:drug effects; D014902:West Nile virus / Q000187:drug effects* / Q000502:physiology
D000998:Antiviral Agents; D012367:RNA, Viral; D013890:Thiourea