title: Randomized comparison of second trimester pregnancy termination utilizing saline moistened or dry misoprostol.
abstract: OBJECTIVE
  The aim of this randomized prospective study was to compare efficacy and side effects of saline moistened misoprostol with dry misoprostol, administered 800 mug intravaginally every 6 h up to a maximum of 3 doses in 24 h for second trimester pregnancy termination.
  
  
  METHODS
  A total of 81 women seeking termination of second trimester pregnancy (55 fetal death, 17 fetal structural anomaly, 5 chromosomal abnormality, 4 other reasons) were randomly assigned to one of two treatment groups: (1) intravaginal non-moistened (dry) misoprostol in group A (n = 40) or (2) misoprostol moistened with 3 ml of saline in group B (n = 41).
  
  
  RESULTS
  All of the patients in either group aborted within 48 h (100% success rate). Delivery was achieved in a median (interquartile range) of 13 (40) h with the group A protocol and 12 (36) h with the group B protocol (P = 0.652). Delivery with first dose, delivery within 12 h and delivery within 24 h were similar (P > 0.05) in group B (34.1, 87.5 and 60%, respectively) and group A (25, 82.9, 46.3, respectively). Both treatment regimens were tolerable and with similar side effects.
  
  
  CONCLUSIONS
  Misoprostol moistened with saline was not more effective than dry misoprostol for second trimester pregnancy termination.
authors: Department of Obstetrics and Gynecology, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey. drbulentyilmaz@yahoo.com
authors: Bulent
authors: B
authors: Yilmaz
authors: Sefa
authors: S
authors: Kelekci
authors: Ibrahim Egemen
authors: IE
authors: Ertas
authors: Murat
authors: M
authors: Ozel
authors: Necdet
authors: N
authors: Sut
authors: Leyla
authors: L
authors: Mollamahmutoglu
authors: Nuri
authors: N
authors: Danisman
mesh_terms: D000019:Abortifacient Agents / Q000008:administration & dosage*; D000032:Abortion, Therapeutic; D000282:Administration, Intravaginal; D000328:Adult; D005260:Female; D006801:Humans; D016595:Misoprostol / Q000008:administration & dosage*; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011446:Prospective Studies; D012965:Sodium Chloride / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D000019:Abortifacient Agents; D016595:Misoprostol; D012965:Sodium Chloride