Exploring the intermembrane space.
Despite the importance that many components of the intermembrane space (IMS) of mitochondria play in cellular function, the targeting sequences that are responsible for transporting proteins to this subcellular compartment are not fully understood. A recent study has identified a minimized protein sequence that is sufficient for localizing the apoptogenic protein Smac/DIABLO in the IMS. This newly identified targeting sequence is capable of directing other proteins to this submitochondrial compartment as well.
Maly
Dustin J
DJ
Department of Chemistry, University of Washington, Seattle, Washington 98195-1700, USA. maly@chem.washington.edu
D051017:Apoptosis Regulatory Proteins; D004258:DNA Polymerase III / Q000235:genetics; D049452:Green Fluorescent Proteins / Q000502:physiology; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000502:physiology*; D051336:Mitochondrial Membranes / Q000502:physiology*; D024101:Mitochondrial Proteins / Q000502:physiology*
D051017:Apoptosis Regulatory Proteins; C412403:DIABLO protein, human; D047908:Intracellular Signaling Peptides and Proteins; D024101:Mitochondrial Proteins; C485184:enhanced green fluorescent protein; D049452:Green Fluorescent Proteins; C074904:DNA polymerase III, alpha subunit; D004258:DNA Polymerase III