Topiramate attenuates a transient learning deficit after lesions inducing intracerebral hemorrhage.
28 male Long-Evans rats prepared with lesions of the middle cerebral artery displayed deficits in spatial navigational learning in a simple version of the Morris Water Maze task not seen in animals prepared with the same injury but administered 4 treatments with topiramate after surgery.
McDaniel
William F
WF
Department of Psychology, Georgia College & State University, Milledgeville, GA 31061-0490, USA. bill.mcdaniel@gcsu.edu
Sawitsky
Alexandra Sondra
AS
Vick
Kara E
KE
D000818:Animals; D002543:Cerebral Hemorrhage / Q000150:complications*; D004195:Disease Models, Animal; D005632:Fructose / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D007859:Learning Disabilities / Q000188:drug therapy* / Q000209:etiology*; D008297:Male; D018782:Maze Learning / Q000187:drug effects*; D018696:Neuroprotective Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D051381:Rats; D020318:Rats, Long-Evans; D000077236:Topiramate
D018696:Neuroprotective Agents; D000077236:Topiramate; D005632:Fructose