title: Simultaneous occurrence of medullary carcinoma and papillary microcarcinoma of thyroid in a patient with MEN 2A syndrome. report of a case.
abstract: We report a case of simultaneous multifocal medullary carcinoma and papillary microcarcinoma in a patient with several distinctive features of MEN 2A. The patient underwent total thyroidectomy and central lymph node dissection. The extreme rarity and pathological features of this occurrence are discussed. There is no known common cause of these 2 different tumor types; it may be a stochastic exception. However, several other possibilities such as a common precursor cell or a common tumorigenic stimulus offer interesting perspectives for speculation.
authors: Department of Surgical Sciences, Policlinico Umberto I, University of Rome La Sapienza, Rome, Italy.
authors: Laura
authors: L
authors: Giacomelli
authors: Gabriella
authors: G
authors: Guerriero
authors: Laura
authors: L
authors: Falvo
authors: Vittorio
authors: V
authors: Altomare
authors: Carlo
authors: C
authors: Chiesa
authors: Simone
authors: S
authors: Ferri
authors: Francesco
authors: F
authors: Stio
mesh_terms: D018276:Carcinoma, Medullary / Q000209:etiology / Q000473:pathology* / Q000503:physiopathology; D002291:Carcinoma, Papillary / Q000209:etiology / Q000473:pathology* / Q000503:physiopathology; D005260:Female; D006042:Goiter / Q000150:complications / Q000188:drug therapy; D006801:Humans; D018813:Multiple Endocrine Neoplasia Type 2a / Q000150:complications*; D009378:Neoplasms, Multiple Primary / Q000209:etiology / Q000473:pathology* / Q000503:physiopathology; D013964:Thyroid Neoplasms / Q000209:etiology / Q000473:pathology* / Q000503:physiopathology; D013974:Thyroxine / Q000627:therapeutic use
chemical_list: D013974:Thyroxine