[Oligodendroglial defect and insufficiency of remyelination during MS: anatomoclinical and experimental comparative study].
BACKGROUND
The mechanisms responsible for the failure of remyelination during MS are poorly understood. We have analyzed in which way oligodendrocytes (OL) could be involved.


METHODS
The number of remyelinated fiber per OL has been determined in 18 chronic MS lesions and compared to normal appearing white matter (NAWM), as well as in the center of lysophosphatidyl choline (LPC)-induced lesions in adult rats in which remyelination was accelerated by microinjection of neurotrophin-3 (NT-3).


RESULTS
In chronic MS lesions and in LPC-induced lesions the number of myelinated fibers per OL was strongly decreased compared to NAWM and to animals treated with NT-3 respectively.


CONCLUSIONS
Our results suggest that the capacity of OL to remyelinate axons could be impaired, due to successive relapses, during MS.
Fressinaud
C
C
Département de Neurologie, UPRES EA 3143, C.H.U., Angers, France. Catherine.fressinaud@univ-angers.fr
D000328:Adult; D000818:Animals; D001369:Axons / Q000473:pathology; D001921:Brain / Q000473:pathology; D002452:Cell Count; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008244:Lysophosphatidylcholines; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000473:pathology*; D009186:Myelin Sheath / Q000473:pathology*; D009412:Nerve Fibers / Q000473:pathology; D020933:Neurotrophin 3 / Q000494:pharmacology; D009836:Oligodendroglia / Q000473:pathology*; D051381:Rats; D017208:Rats, Wistar
D008244:Lysophosphatidylcholines; D020933:Neurotrophin 3