title: Assessing developmental outcomes in children from Kilifi, Kenya, following prophylaxis for seizures in cerebral malaria.
abstract: The purpose of the study was to develop a culture-informed measure of developmental outcome and to apply it to detect differences in developmental level between children with cerebral malaria enrolled in a clinical trial to control seizures during the acute phase of the illness. The instrument was administered to a sample of 180 children, three and 12 months after discharge from hospital. The measure demonstrated high internal consistency, good inter-observer reliability, age sensitivity and strong relations with parental report of child functioning. No association was found between performance, or change in performance, with the prophylactic regime administered. The results suggested that the use of Phenobarbital in controlling provoked seizures has no observable effect on cognitive function.
authors: Centre for Geographic Medicine Research, Coast, Kemri, Kenya and Tilburg University, The Netherlands. A.AbubakarAli@uvt.nl
authors: Amina
authors: A
authors: Abubakar
authors: Fons J R
authors: FJ
authors: Van De Vijver
authors: Sadik
authors: S
authors: Mithwani
authors: Elizabeth
authors: E
authors: Obiero
authors: Naomi
authors: N
authors: Lewa
authors: Simon
authors: S
authors: Kenga
authors: Khamis
authors: K
authors: Katana
authors: Penny
authors: P
authors: Holding
mesh_terms: D000927:Anticonvulsants / Q000627:therapeutic use; D002648:Child; D002657:Child Development / Q000187:drug effects*; D002675:Child, Preschool; D003071:Cognition; D005260:Female; D006801:Humans; D007223:Infant; D007630:Kenya; D016779:Malaria, Cerebral / Q000188:drug therapy / Q000503:physiopathology*; D008297:Male; D017063:Outcome Assessment, Health Care; D010634:Phenobarbital / Q000627:therapeutic use; D011594:Psychometrics; D012640:Seizures / Q000517:prevention & control*
chemical_list: D000927:Anticonvulsants; D010634:Phenobarbital