The role of antileukotriene drugs in management of rhinitis and rhinosinusitis.
Antileukotriene drugs have been studied for more than 15 years. In this review we examine the role of leukotrienes in rhinitis and rhinosinusitis, and explore the clinical literature supporting the use of anti-leukotriene agents in these diseases. Although these medications clearly are efficacious in rhinitis, it is unclear where in the armamentarium they should be used. The evidence for use in sinusitis has not been well studied except in sinusitis-associated aspirin-exacerbated respiratory disease. In this circumstance there is information that allows use of antileukotriene agents to be considered efficacious. We provide our rationale for use and await future clinical studies to answer this important question.
Grayson
Mitchell H
MH
Division of Allergy and Immunology, Department of Internal Medicine, Washington University School of Medicine, Campus Box 8122, 660 South Euclid Avenue, St. Louis, MO 63110, USA. mgrayson@wustl.edu
Korenblat
Phillip E
PE
D000281:Administration, Intranasal; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000627:therapeutic use; D006634:Histamine H1 Antagonists / Q000627:therapeutic use; D006801:Humans; D020024:Leukotriene Antagonists / Q000627:therapeutic use*; D015289:Leukotrienes / Q000378:metabolism*; D012220:Rhinitis / Q000188:drug therapy / Q000276:immunology / Q000378:metabolism; D012852:Sinusitis / Q000188:drug therapy / Q000276:immunology / Q000378:metabolism
D000305:Adrenal Cortex Hormones; D006634:Histamine H1 Antagonists; D020024:Leukotriene Antagonists; D015289:Leukotrienes