Methanol extract of Sorbus commixta cortex prevents vascular inflammation in rats with a high fructose-induced metabolic syndrome.
Feeding high fructose (Frc) to rats induces a moderate increase in blood pressure, which is associated with insulin resistance. The present study was designed to evaluate the effect of the methanol extract of Sorbus commixta cortex (MSC) on vascular inflammation in a rat model of the metabolic syndrome induced by a high Frc-diet. Male Sprague-Dawley rats were divided into 4 groups and treated for 7 weeks as follows: 1) control, 2) high Frc-diet group, 3) Frc/MSC1 group; high Frc-diet group treated with MSC (100 mg/kg/day), and 4) Frc/MSC2 group; high Frc-diet group treated with MSC (200 mg/kg/day). High Frc-induced decreases of the expression level of aortic endothelial nitric oxide synthase (ecNOS) while the production of cyclic GMP (cGMP) was restored by treatment with MSC. On the contrary, increases of the expression level of endothelin-1 (ET-1) in the aorta, the transcription factor, the cytokine related with vascular inflammation, and the adhesion molecules were suppressed by MSC treatment. Moreover, MSC treatment was shown to lessen the thickening noted in the aortic intima and media of the high Frc-diet group. Our findings suggest that MSC may have an anti-vascular inflammatory effect on rats with a high Frc-induced metabolic syndrome.
Kang
Dae Gill
DG
Professional Graduate School of Oriental, Wonkwang University, Iksan, Jeonbuk, 570-749, Korea.
Sohn
Eun Jin
EJ
Lee
An Sook
AS
Kim
Jin Sook
JS
Lee
Dae Ho
DH
Lee
Ho Sub
HS
D000818:Animals; D001013:Aorta, Thoracic / Q000378:metabolism / Q000473:pathology; D015815:Cell Adhesion Molecules / Q000187:drug effects / Q000378:metabolism; D006152:Cyclic GMP / Q000378:metabolism; D004195:Disease Models, Animal; D019332:Endothelin-1 / Q000037:antagonists & inhibitors / Q000378:metabolism; D004730:Endothelium, Vascular / Q000187:drug effects / Q000378:metabolism; D005632:Fructose / Q000009:adverse effects; D006157:Guanosine Monophosphate / Q000378:metabolism; D007249:Inflammation / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control*; D008297:Male; D024821:Metabolic Syndrome / Q000139:chemically induced / Q000150:complications*; D000432:Methanol / Q000494:pharmacology; D016328:NF-kappa B / Q000187:drug effects / Q000378:metabolism; D009573:Nitrites / Q000378:metabolism; D010936:Plant Extracts / Q000494:pharmacology; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D031994:Sorbus; D013549:Sweetening Agents / Q000009:adverse effects; D014280:Triglycerides / Q000097:blood; D017539:Tunica Intima / Q000473:pathology; D017540:Tunica Media / Q000473:pathology
D015815:Cell Adhesion Molecules; D019332:Endothelin-1; D016328:NF-kappa B; D009573:Nitrites; D010936:Plant Extracts; D012333:RNA, Messenger; D013549:Sweetening Agents; D014280:Triglycerides; D005632:Fructose; D006157:Guanosine Monophosphate; D006152:Cyclic GMP; D000432:Methanol