[Atypical mycobacteriosis of the skin caused by Mycobacterium abscessus in an immunocompetent woman].
Mycobacterium abscessus is the most pathogenic of the fast-growing mycobacteria, and it is resistant to most of the antimicrobial and tuberculostatic drugs available. This non-tuberculous mycobacterium is significant in medicine because it can contaminate post-traumatic wounds and be a causative agent in chronic skin and soft tissue infection after surgical procedures.A 60-year-old immunocompetent woman was suffering from chronic ulcers and abscesses on the heels and malleoli of both feet. Histological examination revealed a granulomatous inflammation with detection of acid-fast rods, albeit without fibrinoid necrosis. The repeated detection of atypical mycobacteria, which were ultimately identified as Mycobacterium abscessus, allowed the diagnosis of an atypical mycobacteriosis of the skin. This was successfully treated first with clarithromycin and rifabutin and later with a combination of ethambutol, minocycline, clofazimine and azithromycin.
Nenoff
P
P
Laboratorium für medizinische Mikrobiologie, Strasse des Friedens 8, 04579, Mölbis, Germany. info@mykologie-experten.de
Uhlemann
R
R
Grünewald
T
T
Nenning
H
H
Grunewald
S
S
Paasch
U
U
D000995:Antitubercular Agents / Q000627:therapeutic use; D001706:Biopsy; D054312:Buruli Ulcer / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D002991:Clofazimine / Q000009:adverse effects / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D005533:Foot Dermatoses / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D016523:Foot Ulcer / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D017495:Hyperpigmentation / Q000139:chemically induced; D007121:Immunocompetence; D007917:Leprostatic Agents / Q000009:adverse effects / Q000627:therapeutic use; D008875:Middle Aged; D009165:Mycobacterium Infections, Nontuberculous / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D016926:Mycobacterium chelonae; D016133:Polymerase Chain Reaction; D012008:Recurrence; D019233:Retreatment; D012867:Skin / Q000473:pathology
D000995:Antitubercular Agents; D007917:Leprostatic Agents; D002991:Clofazimine