Synthesis and glycogen phosphorylase inhibitor activity of 2,3-dihydrobenzo[1,4]dioxin derivatives.
Novel 5-benzyl and 5-benzylidene-thiazolidine-2,4-diones carrying 2,3-dihydrobenzo[1,4]dioxin pharmacophore were synthesized and their glycogen phosphorylase inhibitor activity was also studied.
Juhász
László
L
Department of Organic Chemistry, University of Debrecen, H-4010, Debrecen, Hungary. juhaszl@delfin.unideb.hu
Docsa
Tibor
T
Brunyászki
Attila
A
Gergely
Pál
P
Antus
Sándor
S
D004147:Dioxins / Q000138:chemical synthesis* / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D024981:Glycogen Phosphorylase / Q000037:antagonists & inhibitors*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry
C521468:2,3-dihydrobenzo(1,4)dioxin; D004147:Dioxins; D004791:Enzyme Inhibitors; D024981:Glycogen Phosphorylase