title: Iodine status of children living in areas with high nitrate levels in water.
abstract: Several researchers have suggested a possible relationship between nitrate intake and the development of goiter in children. The present cross-sectional study included schoolchildren between the ages of 11 and 14 years from 2 villages in Bulgaria with high and low nitrate levels in drinking water. The comparison between the median urinary iodine levels of the total number of exposed (179.0 microg/l) and nonexposed (202.50 microg/l) children showed statistically significant differences. The relative risk for the children exposed to high nitrate levels in drinking water, expressed as the odds ratio, was 8.145 (95% confidence interval = 1.67-39.67). The authors considered this to be very significant. They found a statistically significant difference for the prevalence of goiter among the exposed and nonexposed children. The results of the study confirmed the role of high nitrate levels in drinking water as a health risk factor for thyroid dysfunction.
authors: Department of Hygiene and Ecomedicine, Medical University, Plovdiv, Bulgaria. gatseva_p@mail.bg
authors: Penka D
authors: PD
authors: Gatseva
authors: Mariana D
authors: MD
authors: Argirova
mesh_terms: D000293:Adolescent; D002031:Bulgaria; D002648:Child; D003430:Cross-Sectional Studies; D005260:Female; D006042:Goiter / Q000139:chemically induced; D006801:Humans; D007455:Iodine / Q000652:urine*; D008297:Male; D009566:Nitrates / Q000009:adverse effects / Q000032:analysis*; D014867:Water / Q000032:analysis*
chemical_list: D009566:Nitrates; D014867:Water; D007455:Iodine