Canine DLA diversity: 1. New alleles and haplotypes.
The aim of this component was to establish the range of DLA diversity in as many dog breeds as possible. In particular, we wanted to collect breeds that had not previously been studied. Data were submitted of 937 dogs of over 80 different breeds, and these included 17 'new' breeds. Twenty-eight new alleles were identified including 21 DLA-DRB1, 2 DLA-DQA1 and 5 DLA-DQB1 alleles. These occurred in many new haplotype combinations. One haplotype was identified that appeared to lack DQB1. Two other haplotypes carry two DQB1 genes. It was clear that each dog breed has a restricted range of DLA alleles and haplotypes, and no breed had all 88 haplotypes identified in this study.
Kennedy
L J
LJ
Centre for Integrated Genomic Medical Research, University of Manchester, Manchester, UK. lorna.kennedy@manchester.ac.uk
Barnes
A
A
Short
A
A
Brown
J J
JJ
Lester
S
S
Seddon
J
J
Fleeman
L
L
Francino
O
O
Brkljacic
M
M
Knyazev
S
S
Happ
G M
GM
Ollier
W E R
WE
D000483:Alleles; D000818:Animals; D004285:Dogs; D014644:Genetic Variation; D005838:Genotype; D006239:Haplotypes / Q000235:genetics*; D015395:Histocompatibility Antigens Class I / Q000235:genetics*
D015395:Histocompatibility Antigens Class I; C039692:histocompatibility antigen DLA