title: Severity of obstructive apnoea in children with Down syndrome who snore.
abstract: Diagnostic overnight polysomnograms of 33 children with Down syndrome who snored were reviewed. Mean age was 4.9 years, none had had adenotonsillectomy, 91% were non-obese (Down syndrome specific body mass index standard deviation score (BMI SDS) <+2.0) and yet 97% demonstrated obstructive sleep apnoea, with an average apnoea hypopnoea index (AHI) of 12.9 episodes per hour (normal <1) and an average oxygen desaturation of 4%. A higher AHI was associated with lower minimum Spo2, higher Tcco2 and higher number of arousals from sleep per hour (p<0.001). Polysomnography should be a routine investigation for children with Down syndrome who snore regardless of body habitus.
authors: University of Sydney, The Children's Hospital at Westmead, Sydney, Australia. dominif2@chw.edu.au
authors: Dominic A
authors: DA
authors: Fitzgerald
authors: Annette
authors: A
authors: Paul
authors: Clare
authors: C
authors: Richmond
mesh_terms: D000293:Adolescent; D000328:Adult; D015992:Body Mass Index; D002245:Carbon Dioxide / Q000097:blood; D002648:Child; D002675:Child, Preschool; D004314:Down Syndrome / Q000097:blood / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D010100:Oxygen / Q000097:blood; D017286:Polysomnography; D012189:Retrospective Studies; D012720:Severity of Illness Index; D020181:Sleep Apnea, Obstructive / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D012913:Snoring / Q000209:etiology*
chemical_list: D002245:Carbon Dioxide; D010100:Oxygen