Relationship between psychiatric status and frontal-subcortical systems in HIV-infected individuals.
Human immunodeficiency virus (HIV)-infected adults frequently evidence both neurocognitive and psychiatric dysfunction. It was hypothesized that apathy and irritability, but not anxiety and depression, are related to HIV effects on frontal-subcortical systems. This hypothesis was evaluated by determining the degree to which these psychiatric features are associated with neurocognitive functioning that is dependent upon frontal-subcortical circuitry and, therefore, thought to be sensitive to the central nervous system effects of HIV. Rating scales assessing irritability, apathy, depression, and anxiety and a dual-task paradigm were administered to 189 HIV-seropositive (HIV+) and 53 HIV-seronegative participants. Deficits in dual-task performance and greater anxiety, depression, apathy, and irritability were observed in HIV+ participants. Simultaneous multivariate regression and communality analyses revealed that only apathy and irritability were associated with dual-task performance in HIV+ participants. Thus, these findings suggest that apathy and irritability, but not depression and anxiety, are likely associated with the effects of HIV on frontal-subcortical circuitry.
Cole
Michael A
MA
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, California 90095, USA. micole@mednet.ucla.edu
Castellon
Steven A
SA
Perkins
Adam C
AC
Ureno
Oscar S
OS
Robinet
Marta B
MB
Reinhard
Matthew J
MJ
Barclay
Terry R
TR
Hinkin
Charles H
CH
D000328:Adult; D000704:Analysis of Variance; D016009:Chi-Square Distribution; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000209:etiology*; D008875:Middle Aged; D009483:Neuropsychological Tests; D011569:Psychiatric Status Rating Scales