Effects of selective cochlear toxicity and vestibular deafferentation on vestibular evoked myogenic potentials in guinea pigs.
CONCLUSIONS
The findings suggest that sound-evoked myogenic potentials on the guinea pig sternocleidomastoid muscle (SM) originate from the vestibular end organ and not from the cochlea of the inner ear.


OBJECTIVE
Studies in animals of the sound evoked vestibular myogenic potentials on the SM should aid in elucidating the pathway of the vestibular-evoked myogenic potential (VEMP). However, details of the pathway of the VEMP remain to be elucidated. This study aimed to clarify aspects of this pathway.


METHODS
In the present study, short latency biphasic myogenic potentials on the SM in guinea pigs were induced by an intense brief sound.


RESULTS
The thresholds of the potentials were 67 dB SPL above those of the auditory brainstem response (ABR). The potentials were eliminated by a vestibular deafferentation, but were observed after selective cochlea toxicity using an amikacin injection.
Shojaku
Hideo
H
Department of Otolaryngology, University of Toyama, Sugitani, Toyama, Japan. hshojaku@med.u-toyama.ac.jp
Zang
Rui Li
RL
Tsubota
Masahito
M
Fujisaka
Michiro
M
Hori
Etsuro
E
Nishijo
Hisao
H
Watanabe
Yukio
Y
D000161:Acoustic Stimulation; D000344:Afferent Pathways / Q000502:physiology; D000583:Amikacin / Q000633:toxicity; D000818:Animals; D001933:Brain Stem / Q000502:physiology; D003051:Cochlea / Q000187:drug effects / Q000502:physiology*; D004576:Electromyography; D016057:Evoked Potentials, Auditory, Brain Stem / Q000502:physiology; D019054:Evoked Potentials, Motor / Q000502:physiology*; D006168:Guinea Pigs; D007273:Injections, Intramuscular; D009334:Neck Muscles / Q000294:innervation*; D011930:Reaction Time / Q000502:physiology; D012684:Sensory Thresholds / Q000502:physiology; D014725:Vestibular Nerve / Q000502:physiology*
D000583:Amikacin