title: Effects of isoflurane on Tei-index of myocardial performance in healthy dogs.
abstract: Recently, the Tei-index, a noninvasive index that combines systolic and diastolic time intervals, has been proposed to assess global cardiac performance. However, the effects of isoflurane on the Tei-index have not been characterized. This study aimed at studying the effects of 1.0 minimal alveolar concentration isoflurane anesthesia on the pre-ejection period (PEP), left ventricular ejection time (LVET), PEP/LVET ratio, isovolumic relaxation time (IVRT), stroke index (SI), cardiac index (CI), heart rate (HR), and the Tei-index in healthy unpremedicated dogs. We observed significant increases in PEP, PEP/LVET ratio, IVRT, and TEI, whose maximal increases obtained throughout the study were 47%, 48%, 78%, and 56%, respectively. The LVET and HR did not change significantly, whereas the SI and CI decreased during anesthesia (29% and 26%, respectively). In conclusion, isoflurane produced direct effects on the Tei-index. The changes in systolic and diastolic parameters were supportive of this finding and were consistent with an overall impairment of left ventricular function during anesthesia.
authors: Departamento de Clínica e Cirurgia Veterinária, Faculdade de Ciências Agrárias e Veterinárias, Universidade Estadual Paulista , Via de Acesso Professor Paulo Donato Castellane, s/no, Jaboticabal, São Paulo, Brazil.
authors: Marlos Gonçalves
authors: MG
authors: Sousa
authors: Roberta
authors: R
authors: Carareto
authors: Andrigo Barboza
authors: AB
authors: De-Nardi
authors: Fábio L C
authors: FL
authors: Brito
authors: Newton
authors: N
authors: Nunes
authors: Aparecido Antonio
authors: AA
authors: Camacho
mesh_terms: D018685:Anesthetics, Inhalation / Q000494:pharmacology*; D000818:Animals; D003971:Diastole / Q000502:physiology; D004285:Dogs / Q000502:physiology*; D004452:Echocardiography / Q000662:veterinary; D005260:Female; D006321:Heart / Q000502:physiology*; D006334:Heart Function Tests / Q000662:veterinary*; D006339:Heart Rate; D007530:Isoflurane / Q000494:pharmacology*; D008297:Male; D013599:Systole / Q000502:physiology
chemical_list: D018685:Anesthetics, Inhalation; D007530:Isoflurane