title: Novel applications of Dermabond (2-octyl -cyanoacrylate) in cardiothoracic surgery.
abstract: Dermabond (Ethicon Inc., Somerville, NJ, USA) is a cyanoacrylate adhesive normally indicated for skin wound closure. This study describes the emergency use of this adhesive to control bleeding close to coronary anastomoses in exceptional cases. Dermabond was used in 17 patients who underwent cardiac surgery during an eight-month period, where other haemostatic interventions were unsuitable. It was applied for haemorrhage in 15 patients and control air leaks in two of the patients. Haemostasis was successful with Dermabond alone in 11 patients; the remaining four required additional interventions. It effectively controlled haemorrhage from ventricular pacing wires, vascular sling holes, peri-anastomotic bleeding, and epicardial tears. The adhesive was not placed directly on any graft because of embolic risk. In the two patients with visible air leaks, it was successfully used. No patient events were recorded as a result of haemorrhage and no reported toxicity. Dermabond may be indicated in circumstances in which haemostasis with traditional methods has failed or is inappropriate. A need for further high-quality objective research exists on the effectiveness and long-term safety of 2-octyl cyanoacrylate in cardiac surgery.
authors: Department of Biosurgery & Surgical Technology, St. Mary's Hospital, Imperial College, London, UK.
authors: Omer
authors: O
authors: Aziz
authors: M S
authors: MS
authors: Rahman
authors: V G
authors: VG
authors: Hadjianastassiou
authors: John
authors: J
authors: Kokotsakis
authors: Malinovski
authors: M
authors: Vitali
authors: Ashok
authors: A
authors: Cherian
authors: Ara
authors: A
authors: Darzi
authors: Thanos
authors: T
authors: Athanasiou
mesh_terms: D013504:Cardiovascular Surgical Procedures / Q000009:adverse effects* / Q000379:methods; D003487:Cyanoacrylates / Q000627:therapeutic use*; D006801:Humans; D019106:Postoperative Hemorrhage / Q000209:etiology* / Q000517:prevention & control*; D019616:Thoracic Surgical Procedures / Q000009:adverse effects* / Q000379:methods; D014014:Tissue Adhesives / Q000627:therapeutic use*; D016896:Treatment Outcome; D014945:Wound Healing / Q000187:drug effects
chemical_list: D003487:Cyanoacrylates; D014014:Tissue Adhesives; C100832:octyl 2-cyanoacrylate