title: [Application of UV similarity in quality control of Chinese medical injection].
abstract: OBJECTIVE
  To propose an algorithm of the similarity between UV-spectra for controlling the quality of Chinese medical injection.
  
  
  METHODS
  The similarity is calculated base on the data of two UV-spectrum curves, thus the sample quality is evaluated according to the average value of the similarity of the UV-spectra between sample with each of standard samples; the proposed algorithm of the similarity is compared with cosine of vectorial angle and relative coefficient; the proposed method for quality evaluation of traditional Chinese injection is discussed with the method according to the chromatographic fingerprint similarity.
  
  
  RESULTS
  The calculated similarity with the proposed method can be sensitive to show the difference between UV-spectra. This proposed method for quality evaluation was applied for assessing quality of 14 batches of Xiangdan injection and the results well coincident with sample quality.
  
  
  CONCLUSIONS
  The proposed method can be used to evaluate the quality of the Chinese medical injection according to the similarity of two UV-spectrum curves.
authors: Department of Analytical Chemistry, China Pharmaceutical University, Nanjing 210009, China. mqhxz@btamail.net.cn
authors: Qing-hua
authors: QH
authors: Meng
authors: Wei-bo
authors: WB
authors: Wang
authors: Yu-zhu
authors: YZ
authors: Hu
mesh_terms: D000465:Algorithms; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D035782:Dalbergia / Q000737:chemistry; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000737:chemistry* / Q000592:standards; D007267:Injections; D010946:Plants, Medicinal / Q000737:chemistry; D011786:Quality Control; D027561:Salvia miltiorrhiza / Q000737:chemistry; D013056:Spectrophotometry, Ultraviolet / Q000379:methods*
chemical_list: D004338:Drug Combinations; D004365:Drugs, Chinese Herbal