title: Digestive processes in ruminal drinkers characterized by means of the acetaminophen absorption test.
abstract: The aim of the present study was to measure transit patterns of nutrients and the absorptive ability in ruminal drinkers (RDs) compared with healthy unweaned calves. The acetaminophen (paracetamol) absorption test was used to characterize the oroduodenal transit rate. Clinical examination and the analysis of various blood parameters provided supplementary information on digestive processes. Three unweaned bucket-fed calves (one RD and two healthy controls) each from seven Swiss dairy farms were included in the study. Measurements (tests 1 and 2) were performed twice at an interval of 10 days. Between tests, the feeding technique of the RDs and one control calf per farm was changed to feeding with a nipple instead of by bucket (without nipple). Acetaminophen appearance in the blood was delayed and reduced in RDs compared with the controls. Acid-base metabolism and several haematological and metabolic parameters differed markedly between RDs and healthy controls. The characteristics of the oroduodenal transit rate, absorptive abilities and clinical status in RDs were nearly normalised within 10 days of reconditioning.
authors: Clinic for Ruminants, Vetsuisse Faculty of the University of Berne, Bremgartenstrasse 109a, Berne, Switzerland.
authors: Madeleine
authors: M
authors: Herrli-Gygi
authors: Adrian
authors: A
authors: Steiner
authors: Marcus G
authors: MG
authors: Doherr
authors: Jürg W
authors: JW
authors: Blum
authors: Marc
authors: M
authors: Kirchhofer
authors: Patrik
authors: P
authors: Zanolari
mesh_terms: D000082:Acetaminophen / Q000493:pharmacokinetics*; D018712:Analgesics, Non-Narcotic / Q000493:pharmacokinetics*; D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism; D000833:Animals, Suckling / Q000378:metabolism; D019540:Area Under Curve; D002417:Cattle / Q000097:blood / Q000378:metabolism*; D004063:Digestion; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects; D005772:Gastrointestinal Transit / Q000187:drug effects; D007408:Intestinal Absorption / Q000187:drug effects; D008297:Male; D014886:Weaning
chemical_list: D018712:Analgesics, Non-Narcotic; D000082:Acetaminophen