title: Chemical etiology of nucleic acids: aminopropyl nucleic acids (APNAs).
abstract: Aminopropyl nucleic acids (APNAs) are constitutionally simple nucleic acid alternatives with one stereogenic center per nucleotide, and with the potential to hybridize with RNA and to exert catalytic functions. We have developed a protecting group strategy to synthesize APNAs, although in a not very efficient way. Isolation and purification of APNAs proved to be difficult. Their structures might be more suited to function as potential catalytic polymers than as information systems that may evolve into RNA.
authors: Laboratory of Medicinal Chemistry, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000 Leuven.
authors: Ding
authors: D
authors: Zhou
authors: Matheus
authors: M
authors: Froeyen
authors: Jozef
authors: J
authors: Rozenski
authors: Arthur
authors: A
authors: Van Aerschot
authors: Piet
authors: P
authors: Herdewijn
mesh_terms: D007202:Indicators and Reagents; D008958:Models, Molecular; D008968:Molecular Conformation; D009696:Nucleic Acids / Q000737:chemistry*; D009841:Oligonucleotides / Q000737:chemistry; D011687:Purines / Q000737:chemistry; D011743:Pyrimidines / Q000737:chemistry
chemical_list: D007202:Indicators and Reagents; D009696:Nucleic Acids; D009841:Oligonucleotides; D011687:Purines; D011743:Pyrimidines