title: Conservative treatment of an atlantoaxial degenerative articular cyst: case report.
abstract: BACKGROUND
  Atlantoaxial degenerative articular cysts are rare lesions that can cause extradural compression of the cervicomedullary junction. When symptomatic, they usually require surgical treatment. We report an unusual case of spontaneous regression of an atlantoaxial degenerative articular cyst after conservative treatment with an external cervical brace along with a systemic therapy with nonsteroidal anti-inflammatory drugs (NSAIDs) and steroids. We also discuss the potential pathogenetic mechanisms involved.
  
  
  OBJECTIVE
  To describe a case of significant volume reduction of an atlantoaxial articular degenerative cyst in a patient treated with a Philadelphia collar and anti-inflammatory drugs.
  
  
  METHODS
  Case report with analysis of the literature.
  
  
  METHODS
  A 80-year-old patient was admitted to our institution with a history of progressive tetraparesis, ataxic gait, and cervical pain. A cervical spine magnetic resonance imaging (MRI) scan showed an extradural mass lesion behind the dens of C2 causing significant compression of the cervicomedullary junction, suggesting the diagnosis of atlantoaxial degenerative articular cyst. The patient refused surgery in favour of a conservative treatment with a Philadelphia collar and a short-term course of NSAIDs and corticosteroids.
  
  
  RESULTS
  After 6 weeks, the patient's neurological condition improved, and a 6-month follow-up cervical spine MRI scan revealed an almost complete regression of the atlantoaxial cystic lesion. At a 1-year follow-up, his clinical condition was further improved.
  
  
  CONCLUSIONS
  Atlantoaxial articular degenerative cysts are rare lesions that should be included in the differential diagnosis of those extradural lesions that can cause a ventral or ventrolateral compression of the cervicomedullary junction. They most commonly occur in elderly female patients affected by diffuse arthrosic degeneration of the cervical spine, with or without clear radiological signs of atlantoaxial instability, and have a typical appearance on MRI imaging. Surgery, with direct excision of the cyst and/or a C1-C2 fusion, is the first treatment of choice. Nevertheless, our report points out the possibility of a significant spontaneous regression of these lesions following a simple conservative strategy based on the use of an external cervical brace together with a systemic anti-inflammatory therapy.
authors: Unitá Operativa di Neurochirurgia, Ospedale Generale Regionale, Via Bohler 5, 39100 Bolzano, Italy. cecchi.pc@libero.it
authors: Paolo Cipriano
authors: PC
authors: Cecchi
authors: Maria Teresa
authors: MT
authors: Peltz
authors: Paolo
authors: P
authors: Rizzo
authors: Angelo
authors: A
authors: Musumeci
authors: Giampietro
authors: G
authors: Pinna
authors: Andreas
authors: A
authors: Schwarz
mesh_terms: D000369:Aged, 80 and over; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D001268:Atlanto-Axial Joint; D001915:Braces; D003131:Combined Modality Therapy; D004008:Diclofenac / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D011241:Prednisone / Q000627:therapeutic use*; D013581:Synovial Cyst / Q000473:pathology / Q000628:therapy*; D016896:Treatment Outcome
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004008:Diclofenac; D011241:Prednisone