title: Autosomal dominant polycystic kidney disease.
abstract: Autosomal dominant polycystic kidney disease is the most prevalent, potentially lethal, monogenic disorder. It is associated with large interfamilial and intrafamilial variability, which can be explained to a large extent by its genetic heterogeneity and modifier genes. An increased understanding of the disorder's underlying genetic, molecular, and cellular mechanisms and a better appreciation of its progression and systemic manifestations have laid out the foundation for the development of clinical trials and potentially effective treatments.
authors: Mayo Clinic College of Medicine, Rochester, MN, USA. Electronic address: torres.vicente@mayo.edu.
authors: Vicente E
authors: VE
authors: Torres
authors: Mayo Clinic College of Medicine, Rochester, MN, USA.
authors: Peter C
authors: PC
authors: Harris
authors: Cliniques St Luc, Université Catholique de Louvain, Brussels, Belgium.
authors: Yves
authors: Y
authors: Pirson
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000209:etiology; D005260:Female; D005838:Genotype; D006801:Humans; D015994:Incidence; D007676:Kidney Failure, Chronic / Q000453:epidemiology / Q000628:therapy; D007684:Kidney Tubules / Q000033:anatomy & histology / Q000378:metabolism / Q000502:physiology; D008297:Male; D010146:Pain / Q000209:etiology; D016891:Polycystic Kidney, Autosomal Dominant / Q000150:complications / Q000235:genetics / Q000503:physiopathology; D017582:Renal Replacement Therapy