title: Quetiapine for agitation or psychosis in patients with dementia and parkinsonism.
abstract: OBJECTIVE
  To assess the efficacy and tolerability of quetiapine for agitation or psychosis in patients with dementia and parkinsonism.
  
  
  METHODS
  Multicenter randomized, double-blind, placebo-controlled parallel groups clinical trial involving 40 patients with dementia with Lewy bodies (n = 23), Parkinson disease (PD) with dementia (n = 9), or Alzheimer disease with parkinsonian features (n = 8). The main outcome measure for efficacy was change in the Brief Psychiatric Rating Scale (BPRS) from baseline to 10 weeks of therapy. For tolerability it was change in the Unified PD Rating Scale (UPDRS) motor section over the same time period. The trial was confounded by the need for a design change and incomplete recruitment.
  
  
  RESULTS
  No significant differences in the primary or secondary outcome measures of efficacy were observed. An unexpectedly large placebo effect, inadequate dosage (mean 120 mg/day), and inadequate power may have contributed to lack of demonstrable benefit. Quetiapine was generally well-tolerated and did not worsen parkinsonism, but was associated with a trend toward a decline on a measure of daily functioning.
  
  
  CONCLUSIONS
  Quetiapine was well-tolerated and did not worsen parkinsonism. Although conclusions about efficacy may be limited, the drug in the dosages used did not show demonstrable benefit for treating agitation or psychosis in patients with dementia and parkinsonism. These findings are in keeping with prior studies reporting limited efficacy of various medications for reducing behavioral problems in demented patients.
authors: Mt. Hope Professional Building, Rochester, NY 14620, USA. Roger_Kurlan@urmc.rochester.edu
authors: Roger
authors: R
authors: Kurlan
authors: Jeffrey
authors: J
authors: Cummings
authors: Rema
authors: R
authors: Raman
authors: Leon
authors: L
authors: Thal
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000150:complications / Q000188:drug therapy; D000978:Antiparkinson Agents / Q000008:administration & dosage / Q000627:therapeutic use; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D002800:Cholinesterase Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use; D015986:Confounding Factors, Epidemiologic; D003704:Dementia / Q000188:drug therapy* / Q000209:etiology; D003987:Dibenzothiazepines / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D000077265:Donepezil; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007189:Indans / Q000008:administration & dosage / Q000627:therapeutic use; D020961:Lewy Body Disease / Q000150:complications / Q000523:psychology*; D008297:Male; D009483:Neuropsychological Tests; D010300:Parkinson Disease / Q000150:complications / Q000523:psychology*; D018579:Patient Selection; D010880:Piperidines / Q000008:administration & dosage / Q000627:therapeutic use; D015990:Placebo Effect; D011595:Psychomotor Agitation / Q000188:drug therapy* / Q000209:etiology; D011618:Psychotic Disorders / Q000188:drug therapy* / Q000209:etiology; D000069348:Quetiapine Fumarate; D012107:Research Design; D012720:Severity of Illness Index; D017211:Treatment Failure
chemical_list: D000978:Antiparkinson Agents; D014150:Antipsychotic Agents; D002800:Cholinesterase Inhibitors; D003987:Dibenzothiazepines; D007189:Indans; D010880:Piperidines; D000069348:Quetiapine Fumarate; D000077265:Donepezil