Anti-inflammatory activity of tetracyclines.
Tetracyclines are known to exhibit multiple significant anti-inflammatory actions. This article describes the mechanisms of this anti-inflammatory activity, such as inhibition of chemotaxis, granuloma formation, and protease. The article also discusses the effectiveness of tetracyclines in treating such diseases as acne vulgaris, rosacea, bullous dermatoses, granulomatous disease, and livedo vasculitis.
Webster
Guy
G
Department of Dermatology, Jefferson Medical College, 833 Chestnut Street, Philadelphia, PA 19107, USA. gfweb@earthlink.net <gfweb@earthlink.net>
Del Rosso
James Q
JQ
D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D006801:Humans; D012871:Skin Diseases / Q000188:drug therapy* / Q000276:immunology; D013754:Tetracyclines / Q000627:therapeutic use*
D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D013754:Tetracyclines