title: Ipsilateral right testicular metastasis from renal cell carcinoma in a responder patient to interleukine-2 treatment.
abstract: We present a case of metastatic spreading to the testicle in a 46-year-old patient with renal cell carcinoma, "clear-cell" type, during interleukin-2 combined subcutaneous plus aerosol treatment. Testicular metastasis occurred while the patient showed a response to the treatment with disappearance of lung lesions and reduction of lymph-nodes lesions. After orchiectomy with spermatic cord resection and disease re-evaluation confirming the previous response, the patient re-started immunotherapy. The contrast between systemic disease response to treatment and disease testicular progression might be explained by a relative insensitivity of the testicle to interleukin-2 immunotherapy as a result of a possible establishment of an immunosuppressive microenvironment. We believe that the rarity of this metastatic site and the intriguing possible mechanisms at its base, makes an interesting case for clinicians.
authors: UOC di Oncologia Medica, Ospedale Unico Versilia, Via Aurelia 335, Lido di Camaiore 55043, Lucca, Italy. andreacamerini@katamail.com
authors: Andrea
authors: A
authors: Camerini
authors: Gianna
authors: G
authors: Tartarelli
authors: Leonardo
authors: L
authors: Martini
authors: Sara
authors: S
authors: Donati
authors: Paolo
authors: P
authors: Puccinelli
authors: Domenico
authors: D
authors: Amoroso
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002292:Carcinoma, Renal Cell / Q000175:diagnosis / Q000188:drug therapy / Q000556:secondary*; D003937:Diagnosis, Differential; D005500:Follow-Up Studies; D006801:Humans; D007376:Interleukin-2 / Q000627:therapeutic use*; D007680:Kidney Neoplasms / Q000188:drug therapy / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D013736:Testicular Neoplasms / Q000175:diagnosis / Q000556:secondary*
chemical_list: D000970:Antineoplastic Agents; D007376:Interleukin-2