title: Natural history of hyperplastic callus formation in osteogenesis imperfecta type V.
abstract: Hyperplastic callus formation was assessed in 23 patients with osteogenesis imperfecta type V. Hyperplastic callus mostly affected long bones in the lower extremities and occurred predominantly during phases of rapid growth.
  
  
  BACKGROUND
  Hyperplastic callus (HPC) formation is one of the most conspicuous features of osteogenesis imperfecta (OI) type V, but the natural history of HPC has not been well characterized.
  
  
  METHODS
  In this retrospective single-center study, we assessed HPC in 23 OI type V patients (9 females and 14 males).
  
  
  RESULTS
  Fifteen patients (65%) had HPC at 48 skeletal sites, 30 of which affected the lower limbs. The number of HPC sites per patient ranged from 0 to 7, with an average of 2.6 for men and 1.1 for women (p = 0.047 for this sex difference; t-test). New HPC formation was observed both after fractures and outside of the context of fractures. Only a minority of lower limb fractures (26%) precipitated HPC formation. After an initial enlargement phase, HPC lesions usually stabilized, but could also resolve completely (n = 2) or progress and lead to bone deformation. The most common complication of HPC was a fracture through the lesion (n = 7). Neither pamidronate nor indomethacin seemed to influence the course of HPC.
  
  
  CONCLUSIONS
  HPC is a potentially serious complication of OI type V. Given the rarity of the disorder, treatment studies will require multicenter collaborations.
authors: Genetics Unit, Shriners Hospital for Children and McGill University, Montréal, Québec, Canada.
authors: Moira S
authors: MS
authors: Cheung
authors: Francis H
authors: FH
authors: Glorieux
authors: Frank
authors: F
authors: Rauch
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002146:Bony Callus / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D006965:Hyperplasia / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010013:Osteogenesis Imperfecta / Q000145:classification* / Q000473:pathology*; D015898:Tomography Scanners, X-Ray Computed