Topical bromfenac sodium for long-term management of vernal keratoconjunctivitis.
OBJECTIVE
We evaluated the efficacy and safety of long-term management of patients with vernal keratoconjunctivitis (VKC) with bromfenac sodium eye drops in combination with corticosteroids and anti-allergic eye drops.


METHODS
Twenty-two patients with VKC were randomly assigned to receive two test eye drops, either bromfenac sodium 0.1% (group A) or placebo eye drops (normal saline; group B) for a mean observation period of 20.9 months. Topical corticosteroids and mast cell stabilizers were continued during the observation period.


RESULTS
The mean 2-year recurrence rate was 90.9% in group A and 11.3% in group B, with a significant difference. No serious side effect was observed in group A.


CONCLUSIONS
These results suggest that bromfenac sodium eye drops can be used as baseline local treatment in patients with VKC.
Uchio
Eiichi
E
Department of Ophthalmology, Fukuoka University School of Medicine, Fukuoka, Japan. euchio@fukuoka-u.ac.jp
Itoh
Yuki
Y
Kadonosono
Kazuaki
K
D000293:Adolescent; D000328:Adult; D018926:Anti-Allergic Agents / Q000008:administration & dosage; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D001577:Benzophenones / Q000008:administration & dosage*; D001969:Bromobenzenes / Q000008:administration & dosage*; D002648:Child; D002675:Child, Preschool; D003228:Conjunctiva / Q000187:drug effects / Q000473:pathology; D003233:Conjunctivitis, Allergic / Q000188:drug therapy* / Q000473:pathology; D003315:Cornea / Q000187:drug effects / Q000473:pathology; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000008:administration & dosage; D006801:Humans; D008297:Male; D009883:Ophthalmic Solutions; D012720:Severity of Illness Index; D013997:Time Factors; D016896:Treatment Outcome; D062367:ortho-Aminobenzoates / Q000008:administration & dosage
D018926:Anti-Allergic Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001577:Benzophenones; D001969:Bromobenzenes; D005938:Glucocorticoids; D009883:Ophthalmic Solutions; D062367:ortho-Aminobenzoates; C053083:bromfenac; C012293:tranilast