title: Dietary protein restriction decreases oxidative protein damage, peroxidizability index, and mitochondrial complex I content in rat liver.
abstract: Caloric restriction (CR) decreases oxidative damage, which contributes to the slowing of aging rate. It is not known if such decreases are due to calories themselves or specific dietary components. In this work, the ingestion of proteins of Wistar rats was decreased by 40% below that of controls. After 7 weeks, the liver of the protein-restricted (PR) animals showed decreases in oxidative protein damage, degree of membrane unsaturation, and mitochondrial complex I content. The results and previous information suggest that the decrease in the rate of aging induced by PR can be due in part to decreases in mitochondrial reactive oxygen species production and DNA and protein oxidative modification, increases in fatty acid components more resistant to oxidative damage, and decreased expression of complex I, analogously to what occurs during CR. Recent studies suggest that those benefits of PR could be caused, in turn, by the lowered methionine intake of that dietary manipulation.
authors: Department of Basic Medical Sciences, Faculty of Medicine, University of Lleida, Spain.
authors: Victoria
authors: V
authors: Ayala
authors: Alba
authors: A
authors: Naudí
authors: Alberto
authors: A
authors: Sanz
authors: Pilar
authors: P
authors: Caro
authors: Manuel
authors: M
authors: Portero-Otin
authors: Gustavo
authors: G
authors: Barja
authors: Reinald
authors: R
authors: Pamplona
mesh_terms: D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D018753:Diet, Protein-Restricted; D042967:Electron Transport Complex I / Q000378:metabolism*; D003576:Electron Transport Complex IV / Q000378:metabolism; D005227:Fatty Acids / Q000378:metabolism; D006706:Homeostasis; D008099:Liver / Q000378:metabolism*; D008297:Male; D008930:Mitochondria, Liver / Q000378:metabolism; D010084:Oxidation-Reduction; D010545:Peroxides / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000596:Amino Acids; D015415:Biomarkers; D005227:Fatty Acids; D010545:Peroxides; D011506:Proteins; D003576:Electron Transport Complex IV; D042967:Electron Transport Complex I