title: Global phylogeography of Mycobacterium tuberculosis and implications for tuberculosis product development.
abstract: New tools for controlling tuberculosis are urgently needed. Despite our emerging understanding of the biogeography of Mycobacterium tuberculosis, the implications for development of new diagnostics, drugs, and vaccines is unknown. M tuberculosis has a clonal genetic population structure that is geographically constrained. Evidence suggests strain-specific differences in virulence and immunogenicity in light of this global phylogeography. We propose a strain selection framework, based on robust phylogenetic markers, which will allow for systematic and comprehensive evaluation of new tools for tuberculosis control.
authors: Institute for Systems Biology, Seattle, WA, USA. sagagneux@systemsbiology.org
authors: Sebastien
authors: S
authors: Gagneux
authors: Peter M
authors: PM
authors: Small
mesh_terms: D000818:Animals; D005843:Geography; D006801:Humans; D009169:Mycobacterium tuberculosis / Q000235:genetics* / Q000302:isolation & purification; D010802:Phylogeny; D014376:Tuberculosis / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology* / Q000517:prevention & control