Efficacy of hepatitis B vaccine in susceptible spouses of chronic hepatitis B virus infected individuals at the time of marriage.
OBJECTIVE
To evaluate the efficacy of hepatitis B virus (HBV) vaccine in susceptible spouses at the time of marriage.


METHODS
From April 2003 to December 2005, 60 cases of susceptible wives of infected husbands and 32 cases of susceptible husbands of the infected wives in Babol north of Iran, received recombinant hepatitis B (HB) vaccine at the time of marriage followed with the second and third doses at 1, and 6 months. Post vaccination tests for hepatitis B surface antigen (HBsAg), anti-HBs and anti-hepatitis B core (HBc) were assessed 2 months of the later dose. The HBs antibody levels of > or = 10 mIU/ml was considered to be protective. Those with anti-HBs levels of <10 mIU/l received the second series of HBV vaccination.


RESULTS
The mean age of the infected husbands was 26.4 +/- 6 years and for infected wives were 22.7 +/- 4.7 years. Seventy (76.1%) cases were HBsAg and anti-hepatitis B e (HBe) positive. Among the recipients of vaccine, the mean age of females was 19 +/- 3.8 years and in males was 25.2 +/- 4.8 years (p=0.007). The HBs antibody levels of > or = 10 mIU/ml were detected in 79 (85.9%) cases. The HBs antibody levels of >100 mIU/ml were developed in 76.7% males and in 75% females (p=0.430). Twelve (13%) cases were non-responder and among them 11 (91.7%) cases responded to the second course of HBV vaccination. The HBs and HBc antibodies were developed in one case.


CONCLUSIONS
This study shows that administration of hepatitis B vaccine at the time of marriage prevents the transmission of hepatitis B virus in susceptible spouses.
Roushan
Mohammad R
MR
Department of Infectious Diseases, Babol Medical University, Babol 4717641367, Iran. hagar2q@yahoo.ca
Samie
Hayedeh
H
Amiri
Mohammad J S
MJ
D000328:Adult; D005260:Female; D006510:Hepatitis B Antibodies / Q000097:blood; D017325:Hepatitis B Vaccines / Q000008:administration & dosage / Q000276:immunology*; D006515:Hepatitis B virus / Q000276:immunology*; D019694:Hepatitis B, Chronic / Q000097:blood / Q000276:immunology* / Q000517:prevention & control / Q000635:transmission; D006801:Humans; D007115:Immunization Schedule; D007492:Iran; D008297:Male; D008393:Marriage; D018454:Spouses; D016896:Treatment Outcome
D006510:Hepatitis B Antibodies; D017325:Hepatitis B Vaccines