Age-related macular degeneration in very old individuals with family history.
OBJECTIVE
To study age-related macular degeneration (AMD) in old and very old individuals with family history of AMD to find the proportion of those with early and advanced AMD.


METHODS
Retrospective cross-sectional cohort study of individuals with family history of AMD.


METHODS
Database of 897 AMD patients ages 75 to 102 years with family history of AMD was compiled. Color fundus photographs were graded in a masked fashion according to the International Classification of AMD.


RESULTS
With increasing age, a gradually larger proportion of participants had advanced AMD; 54% (469 of 863) of all those 75 years and older had advanced AMD, 64% (258 of 406) of all those 85 years and older, 74% (37 of 50) of all those 95 years and older, and all (eight of eight) 100 years and older had advanced AMD.


CONCLUSIONS
All the centenarians in the present study had advanced AMD.
Geirsdottir
Asbjorg
A
Department of Ophthalmology, Landspitali-University Hospital, Reykjavik, Iceland.
Stefansson
Einar
E
Jonasson
Fridbert
F
Helgadottir
Gudleif
G
Sigurdsson
Haraldur
H
D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D005192:Family Health; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007055:Iceland / Q000453:epidemiology; D008268:Macular Degeneration / Q000453:epidemiology* / Q000235:genetics*; D008297:Male; D012189:Retrospective Studies