Chemical etiology of nucleic acids: aminopropyl nucleic acids (APNAs).
Aminopropyl nucleic acids (APNAs) are constitutionally simple nucleic acid alternatives with one stereogenic center per nucleotide, and with the potential to hybridize with RNA and to exert catalytic functions. We have developed a protecting group strategy to synthesize APNAs, although in a not very efficient way. Isolation and purification of APNAs proved to be difficult. Their structures might be more suited to function as potential catalytic polymers than as information systems that may evolve into RNA.
Zhou
Ding
D
Laboratory of Medicinal Chemistry, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000 Leuven.
Froeyen
Matheus
M
Rozenski
Jozef
J
Van Aerschot
Arthur
A
Herdewijn
Piet
P
D007202:Indicators and Reagents; D008958:Models, Molecular; D008968:Molecular Conformation; D009696:Nucleic Acids / Q000737:chemistry*; D009841:Oligonucleotides / Q000737:chemistry; D011687:Purines / Q000737:chemistry; D011743:Pyrimidines / Q000737:chemistry
D007202:Indicators and Reagents; D009696:Nucleic Acids; D009841:Oligonucleotides; D011687:Purines; D011743:Pyrimidines