Psoralea corylifolia L. inhibits mitochondrial complex I and proteasome activities in SH-SY5Y cells.
The growing interest in alternative medicines, including traditional medicinal plants, has caused some health concerns due to poor awareness in the general population of the possible side effects from inappropriate practices. Psoralea corylifolia L. has been used in Chinese and Indian traditional medicine for the treatment of various inflammatory diseases of the skin and to improve vitality. Our data show that the extract obtained from the seeds of Psoralea corylifolia L. decreased mitochondrial complex I and proteasome activities; and oxidative stress might be an early event.
Tang
Soon Yew
SY
National University of Singapore, University Hall, Lee Kong Chian Wing, UHL 05-02G, 21 Lower Kent Ridge Road, Singapore. bchbh@nus.edu.sg
Gruber
Jan
J
Wong
Kim Ping
KP
Halliwell
Barry
B
D000818:Animals; D001921:Brain / Q000378:metabolism; D045744:Cell Line, Tumor; D006801:Humans; D008516:Medicine, Chinese Traditional; D051379:Mice; D008928:Mitochondria / Q000378:metabolism; D008954:Models, Biological; D009245:NADH Dehydrogenase / Q000378:metabolism; D018384:Oxidative Stress; D010946:Plants, Medicinal / Q000378:metabolism; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism*; D029907:Psoralea / Q000378:metabolism*; D017382:Reactive Oxygen Species; D013778:Tetrazolium Salts / Q000494:pharmacology; D013844:Thiazoles / Q000494:pharmacology
D017382:Reactive Oxygen Species; D013778:Tetrazolium Salts; D013844:Thiazoles; D009245:NADH Dehydrogenase; D046988:Proteasome Endopeptidase Complex; C022616:thiazolyl blue