New mechanism for an old drug: aspirin triggers anti-inflammatory lipid mediators with gender implications.
Aspirin increases anti-inflammatory aspirin-triggered lipoxin A4 levels in healthy subjects in a gender-specific manner in a randomized clinical study. Thus, formation of aspirin-triggered lipoxin A4 may provide a novel mechanism underlying aspirin's clinical benefits, and shed light on gender-dependent therapeutics of aspirin.
Chiang
Nan
N
The Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Serhan
Charles N
CN
D000107:Acetylation; D001241:Aspirin / Q000494:pharmacology*; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology*; D006801:Humans; D044045:Lipoxins / Q000096:biosynthesis*; D009504:Neutrophils / Q000378:metabolism; D016032:Randomized Controlled Trials as Topic; D012737:Sex Factors; D013929:Thromboxane B2 / Q000037:antagonists & inhibitors
D016861:Cyclooxygenase Inhibitors; D044045:Lipoxins; C040527:lipoxin A4; D013929:Thromboxane B2; D001241:Aspirin