A search for the plant ingredients that protect cells from air pollutants and benz[a]pyrene phototoxicity.
A diversity of antioxidants and plant ingredients were examined for their protective effect in cultured Balb/c 3T3 cells against ultraviolet A (UVA)-induced cytotoxicities of extracted air pollutants and benz[a]pyrene (B[a]P) in an effort to find effective protectors against the phototoxicity of air pollutants and B[a]P. As has been observed for B[a]P phototoxicity, air pollutants themselves and those previously exposed to UVA light in the absence of cells exhibited faintly weak cytotoxicity, but the toxicity was markedly elevated when they were exposed to UVA light concomitantly with cells. The B[a]P phototoxicity was not eliminated by well-known antioxidants but was markedly diminished by diversity of plant ingredients. Among the plant ingredients tested in the current study, morin, naringin, and quercetin were found to be desirable protectors against B[a]P phototoxicity.
Hori
M
M
Research & Development Department, Ichimaru Pharcos Co., Ltd., Gifu, Japan.
Kojima
H
H
Nakata
S
S
Konishi
H
H
Kitagawa
A
A
Kawai
K
K
D000393:Air Pollutants / Q000633:toxicity*; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D041702:BALB 3T3 Cells; D001564:Benzo(a)pyrene / Q000633:toxicity*; D051379:Mice; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry; D014466:Ultraviolet Rays / Q000009:adverse effects*
D000393:Air Pollutants; D000975:Antioxidants; D010936:Plant Extracts; D001564:Benzo(a)pyrene