Use of oral glycopyrronium bromide in hyperhidrosis.
BACKGROUND
Idiopathic hyperhidrosis may be a disabling condition causing emotional stress and negative impact on a patient's quality of life. Oral anticholinergics are one of the treatments available. There are few published data on the use of the anticholinergic drug glycopyrronium bromide (glycopyrrolate) given orally in the treatment of hyperhidrosis.


OBJECTIVE
To report a retrospective analysis describing the treatment responses, doses and side-effects of oral glycopyrrolate in the treatment of idiopathic hyperhidrosis.


METHODS
Review of case notes in a series of 24 patients, nine with generalized and 15 with localized hyperhidrosis.


RESULTS
Fifteen of 19 evaluable patients (79%) responded to oral glycopyrrolate. However, treatment was limited by side-effects in around one third of patients.


CONCLUSIONS
A prospective clinical study to compare the efficacy and side-effects of oral anticholinergics is warranted.
Bajaj
V
V
Department of Dermatology, University Hospital of North Durham, Durham DH1 5TW, UK. vrinda_bajaj@hotmail.com
Langtry
J A A
JA
D000284:Administration, Oral; D000328:Adult; D018680:Cholinergic Antagonists / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D006024:Glycopyrrolate / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D006945:Hyperhidrosis / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D018727:Muscarinic Antagonists / Q000008:administration & dosage* / Q000009:adverse effects; D011788:Quality of Life / Q000523:psychology; D012189:Retrospective Studies; D016896:Treatment Outcome
D018680:Cholinergic Antagonists; D018727:Muscarinic Antagonists; D006024:Glycopyrrolate