Easily accessible benzamide-derived P,O ligands (Bphos) for palladium-catalyzed carbon-nitrogen bond-forming reactions.
Easily accessible benzamide-derived hemilabile phosphine ligands were efficiently prepared through ortho-directed lithiation of the corresponding N,N-diethylbenzamide followed by quenching with chlorodialkylphosphines. These structurally simple hemilabile ligands were found to be highly effective in palladium-catalyzed amination of aryl and heteroaryl chlorides. Various sterically congested and functionalized aryl halide substrates were compatible in these reaction conditions. By using optimized reaction conditions, remarkable catalyst productivity (total turnover number up to 8400) was obtained.
Chen
Guoshu
G
State Key Laboratory of Chinese Medicine and Molecular Pharmacology, Shenzhen, China.
Lam
Wai Har
WH
Fok
Wai Shan
WS
Lee
Hang Wai
HW
Kwong
Fuk Yee
FY
D000586:Amination; D001549:Benzamides / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D010165:Palladium / Q000737:chemistry; D010720:Phosphines / Q000138:chemical synthesis*
D001549:Benzamides; D010720:Phosphines; D010165:Palladium