title: The effect of compound nutrients on stress-induced changes in serum IL-2, IL-6 and TNF-alpha levels in rats.
abstract: The effect of compound nutrients on serum concentrations of the cytokines, such as interleukin (IL)-2, tumor necrosis factor-alpha (TNF-alpha) and interleukin (IL)-6 in immobilization and cold water-immersion stressed rat were investigated. Oral (gavage) administration of compound nutrients was found to attenuate the acute and chronic immobilization and cold water-immersion stress-induced increase in serum IL-6 level and decrease in IL-2 level. Compound nutrients exerted different effects on TNF-alpha level in two different models studied, with reduced serum TNF-alpha level in acute stress, while no significant effect in chronic stress. These results suggested that compound nutrients might be proposed as a possible candidate in the research or therapeutic modulation of stress-related disorders.
authors: Department of Physiology, The Fourth Military Medical University, Xi'an 710032, Shaanxi, China. yaliliu@fmmu.edu.cn
authors: Ya-Li
authors: YL
authors: Liu
authors: Hui
authors: H
authors: Bi
authors: Su-Min
authors: SM
authors: Chi
authors: Rong
authors: R
authors: Fan
authors: Yue-Min
authors: YM
authors: Wang
authors: Xin-Liang
authors: XL
authors: Ma
authors: Yao-Ming
authors: YM
authors: Chen
authors: Wen-Jing
authors: WJ
authors: Luo
authors: Jian-Ming
authors: JM
authors: Pei
authors: Jing-Yuan
authors: JY
authors: Chen
mesh_terms: D000821:Animal Feed; D000818:Animals; D007376:Interleukin-2 / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013312:Stress, Physiological / Q000097:blood*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*
chemical_list: D007376:Interleukin-2; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha