title: Intracerebroventricular physostigmine enhances blood pressure and heat loss in running rats.
abstract: The aim of this study was to evaluate the effects of the stimulation of central cholinergic synapses in the regulation of heat loss in untrained rats during exercise. The animals were separated into two groups (exercise or rest) and tail skin temperature (T(tail)), core temperature and blood pressure were measured after injection of 2 microL of 5x10(-3) M physostigmine (Phy; n = 8) or 0.15 M NaCl solution (Sal; n = 8) into the lateral cerebral ventricle. Blood pressure was recorded by a catheter implanted into the abdominal aorta, T(tail) was measured using a thermistor taped to the tail and intraperitoneal temperature (T(b)) was recorded by telemetry. During exercise, Phy-treated rats had a higher increase in mean blood pressure (147 +/- 4 mmHg Phy vs. 121 +/- 3 mmHg Sal; P < 0.001) and higher T(tail) (26.4 +/- 1.0 degrees C Phy vs. 23.8 +/- 0.5 degrees C Sal; P < 0.05) that was closely related to the increase in systolic arterial pressure (r = 0.83; P < 0.001). In addition, Phy injection attenuated the exercise-induced increase in T(b) compared with controls without affecting running time. We conclude that the activation of central cholinergic synapses during exercise increases heat dissipation due to the higher increase in blood pressure.
authors: Laboratory of Exercise Physiology, Department of Physical Education, School of Physical Education, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
authors: W
authors: W
authors: Pires
authors: S P
authors: SP
authors: Wanner
authors: R B
authors: RB
authors: La Guardia
authors: L O C
authors: LO
authors: Rodrigues
authors: S A
authors: SA
authors: Silveira
authors: C C
authors: CC
authors: Coimbra
authors: U
authors: U
authors: Marubayashi
authors: N R V
authors: NR
authors: Lima
mesh_terms: D000109:Acetylcholine / Q000378:metabolism; D000818:Animals; D019540:Area Under Curve; D001794:Blood Pressure / Q000187:drug effects*; D001833:Body Temperature Regulation / Q000187:drug effects*; D001921:Brain / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D002800:Cholinesterase Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*; D007276:Injections, Intraventricular; D008297:Male; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D010805:Physical Conditioning, Animal; D005082:Physical Exertion / Q000502:physiology*; D010830:Physostigmine / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012420:Running; D012881:Skin Temperature / Q000187:drug effects; D009435:Synaptic Transmission / Q000187:drug effects; D013686:Telemetry; D013997:Time Factors
chemical_list: D002800:Cholinesterase Inhibitors; D010830:Physostigmine; D000109:Acetylcholine