title: Risk factors for cardiovascular disease in women with a history of pregnancy complicated by preeclampsia or intrauterine growth restriction.
abstract: OBJECTIVE
  Women with a history of preeclampsia or intrauterine growth restriction (IUGR) have an increased risk for cardiovascular disease in later life. We determined the presence of traditional and novel risk factors for cardiovascular disease in these women.
  
  
  METHODS
  We studied 256 women with a history of preeclampsia and 59 women with a history of intrauterine growth restriction. Fifty-three women with a history of uncomplicated pregnancy served as controls. We determined values for blood pressure, body mass index, concentrations of cholesterol, high-density lipoprotein cholesterol, triglycerides and lipoprotein (a), and insulin resistance.
  
  
  RESULTS
  Women with a history of preeclampsia exhibited more risk factors for future cardiovascular disease such as dyslipidemia, hypertension, obesity, and increased insulin resistance compared with women with a history of uncomplicated pregnancy. Women with a history of IUGR have higher concentrations of cholesterol and show a tendency to higher BMI, higher triglyceride concentrations, and increased insulin resistance as compared with women with a history of normal pregnancy.
  
  
  CONCLUSIONS
  Preeclampsia or IUGR may represent an early marker for increased risk for early cardiovascular disease.
authors: Department of Perinatology and Gynecology, University Medical Center, Utrecht, The Netherlands. wmantel@veldhuizen.speedxs.nl
authors: Gwendolyn T R
authors: GT
authors: Manten
authors: Marko J
authors: MJ
authors: Sikkema
authors: Hieronymus A M
authors: HA
authors: Voorbij
authors: Gerard H A
authors: GH
authors: Visser
authors: Hein W
authors: HW
authors: Bruinse
authors: Arie
authors: A
authors: Franx
mesh_terms: D000328:Adult; D001794:Blood Pressure; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000453:epidemiology* / Q000503:physiopathology; D005260:Female; D005317:Fetal Growth Retardation / Q000097:blood / Q000453:epidemiology* / Q000503:physiopathology; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D017270:Lipoprotein(a) / Q000097:blood; D011225:Pre-Eclampsia / Q000097:blood / Q000453:epidemiology* / Q000503:physiopathology; D011247:Pregnancy; D012307:Risk Factors
chemical_list: D017270:Lipoprotein(a)