The significance of bone microstructure in mechanotransduction.
Recent developments in modeling the relationship between bone microstructure and mechanotransduction are reviewed. The focus is on the relationship between the bone microstructure and the mechanosensation mechanism by which osteocytes sense the bone fluid motion propelled by the mechanical loading of the whole bone.
Cowin
Stephen C
SC
Departments of Biomedical and Mechanical Engineering, New York Center for Biomedical Engineering, School of Engineering of The City College, Graduate School of The City University of New York, New York, NY 10031, USA. scowin@earthlink.net
D001696:Biomechanical Phenomena; D001842:Bone and Bones / Q000166:cytology / Q000648:ultrastructure*; D006801:Humans; D040542:Mechanotransduction, Cellular / Q000502:physiology*; D010011:Osteocytes / Q000502:physiology*; D014882:Water-Electrolyte Balance