Quorum sensing enhances the stress response in Vibrio cholerae.
Vibrio cholerae lives in aquatic environments and causes cholera. Here, we show that quorum sensing enhances V. cholerae viability under certain stress conditions by upregulating the expression of RpoS, and this regulation acts through HapR, suggesting that a quorum-sensing-enhanced stress response plays a role in V. cholerae environmental survival.
Joelsson
Adam
A
Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
Kan
Biao
B
Zhu
Jun
J
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D019677:Artificial Gene Fusion; D001426:Bacterial Proteins / Q000096:biosynthesis / Q000502:physiology; D015964:Gene Expression Regulation, Bacterial; D017930:Genes, Reporter; D006861:Hydrogen Peroxide / Q000494:pharmacology; D050296:Microbial Viability; D018384:Oxidative Stress; D053038:Quorum Sensing / Q000502:physiology*; D012808:Sigma Factor / Q000096:biosynthesis / Q000502:physiology; D015854:Up-Regulation; D014734:Vibrio cholerae / Q000235:genetics / Q000502:physiology*; D001616:beta-Galactosidase / Q000032:analysis / Q000235:genetics
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D012808:Sigma Factor; C069567:sigma factor KatF protein, Bacteria; D006861:Hydrogen Peroxide; D001616:beta-Galactosidase