title: CCR5 receptor: biologic and genetic implications in age-related diseases.
abstract: The CC chemokine receptor 5 (CCR5) is a member of CC-chemokine receptor family. CCR5 has the characteristic structure of a seven transmembrane G protein-coupled receptor (GPCR), which regulates trafficking and effector functions of memory/effector Th1 cells, macrophages, NK cells, and immature dendritic cells. CCR5 and its ligands are important molecules in viral pathogenesis. CCR5 represents the co-receptor for macrophage (M) and dual (T cell and M)-tropic immunodeficiency viruses. Recent evidence has also demonstrated the role of CCR5 in a variety of human diseases, ranging from infectious and inflammatory diseases to cancer. In this article, we describe the involvement of CCR5 in two age-related diseases, atherosclerosis and Alzheimer's disease, suggesting a possible role of chemokine system on these diseases' pathophysiology. Finally, we review the data on the probable association between CCR5Delta32 deletion and cardiovascular diseases and Alzheimer's disease.
authors: Gruppo di Studio sull'Immunosenescenza, Dipartimento di Biopatologia e Metodologie Biomediche, Corso Tukory 211, 90134 Palermo, Italy. crbalistreri@unipa.it
authors: Carmela Rita
authors: CR
authors: Balistreri
authors: Calogero
authors: C
authors: Caruso
authors: Maria Paola
authors: MP
authors: Grimaldi
authors: Florinda
authors: F
authors: Listì
authors: Sonya
authors: S
authors: Vasto
authors: Valentina
authors: V
authors: Orlando
authors: Anna Maria
authors: AM
authors: Campagna
authors: Domenico
authors: D
authors: Lio
authors: Giuseppina
authors: G
authors: Candore
mesh_terms: D000375:Aging; D000544:Alzheimer Disease / Q000235:genetics / Q000378:metabolism; D050197:Atherosclerosis / Q000235:genetics; D002318:Cardiovascular Diseases / Q000235:genetics* / Q000378:metabolism; D003713:Dendritic Cells / Q000166:cytology; D017353:Gene Deletion; D016678:Genome; D006801:Humans; D007249:Inflammation; D007694:Killer Cells, Natural / Q000378:metabolism; D008024:Ligands; D008264:Macrophages / Q000378:metabolism; D017628:Microglia / Q000473:pathology; D008954:Models, Biological; D019713:Receptors, CCR5 / Q000235:genetics* / Q000502:physiology*
chemical_list: D008024:Ligands; D019713:Receptors, CCR5