Desymmetrization of 1,4-cyclohexadienyltriisopropoxysilane using copper catalysis.
The first catalytic desymmetrization in the field of allylsilane chemistry is presented. Desymmetrization of cyclohexadienyltriisopropoxysilane is achieved using coppper catalysis. High diastereo- and enantioselectivities are obtained, and the product dienes are highly valuable building blocks for natural product synthesis.
Umeda
Rui
R
Organisch-Chemisches Institut, Westfälische Wilhelms-Universität, Corrensstrasse 40, 48149 Münster, Germany.
Studer
Armido
A