title: Inhibition of infection of the rice blast fungus by halisulfate 1, an isocitrate lyase inhibitor.
abstract: Halisulfate 1, a sesterterpene sulfate and an isocitrate lyase (ICL) inhibitor that is isolated from tropical sponge Hippospongia spp., reduces both appressorium formation and infection of rice plants by the fungus Magnaporthe grisea. Rice plants infected with wild-type M. grisea Guy 11 exhibited significantly lower disease severity after halisulfate 1 treatment than without, and the treatment effect was comparable to the behavior of the Delta icl knockout mutant I-10. The protection observed upon applying halisulfate 1 to rice plants suggests that the ICL inhibitor may be a promising candidate for crop protection, particularly to protect rice plants against M. grisea.
authors: Center for Agricultural Biomaterials, Seoul National University, Seoul, Korea.
authors: Dong-Sun
authors: DS
authors: Shin
authors: Tae-Hoon
authors: TH
authors: Lee
authors: Hyi-Seung
authors: HS
authors: Lee
authors: Jongheon
authors: J
authors: Shin
authors: Ki-Bong
authors: KB
authors: Oh
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D005656:Fungal Proteins / Q000037:antagonists & inhibitors / Q000235:genetics; D017353:Gene Deletion; D007522:Isocitrate Lyase / Q000037:antagonists & inhibitors* / Q000235:genetics; D020082:Magnaporthe / Q000187:drug effects* / Q000235:genetics / Q000472:pathogenicity*; D015394:Molecular Structure; D012275:Oryza / Q000382:microbiology*; D010935:Plant Diseases / Q000382:microbiology*; D054830:Sesterterpenes; D013172:Spores, Fungal / Q000187:drug effects; D013729:Terpenes / Q000494:pharmacology*
chemical_list: D000935:Antifungal Agents; D004791:Enzyme Inhibitors; D005656:Fungal Proteins; D054830:Sesterterpenes; D013729:Terpenes; C522705:halisulfate 1; D007522:Isocitrate Lyase