title: Mutagenic evaluation and chemical investigation of Byrsonima intermedia A. Juss. leaf extracts.
abstract: Byrsonima intermedia is a native species of the cerrado formation (tropical American savannah). In Brazil, this plant has been used for the treatment of fever, in ulcers, as a diuretic, as antiasthmatics and in skin infections. Members of the genus Byrsonima (Malpighiaceae) are employed not only in the folk medicine but also as food to make juice, jellies and liquor. The aim of this work was to evaluate the mutagenic effects of Byrsonima intermedia, common name 'murici'. Phytochemical analysis of methanol extract furnished (+)-catechin, (-)-epicatechin, quercetin-3-O-beta-d-galactopyranoside, methyl gallate, gallic acid, quercetin-3-O-alpha-l-arabinopyranoside, amentoflavone, quercetin, quercetin-3-O-(2''-O-galloyl)-beta-galactopyranoside and quercetin-3-O-(2''-O-galloyl)-alpha-arabinopyranoside. Methanol, hydromethanol and chloroform extracts were evaluated in mutagenic assay with Salmonella typhimurium (Ames test) and mice (Micronucleus test). The methanolic extract presented signs of mutagenic activity for the strains TA98 and TA100 in the Ames assay. Mutagenicity was not observed in vivo.
authors: Araraquara Institute of Chemistry, São Paulo State University, Araraquara, SP, Brazil.
authors: Miriam
authors: M
authors: Sannomiya
authors: Cássia R P
authors: CR
authors: Cardoso
authors: Maria E
authors: ME
authors: Figueiredo
authors: Clenilson M
authors: CM
authors: Rodrigues
authors: Lourdes C
authors: LC
authors: dos Santos
authors: Fabio V
authors: FV
authors: dos Santos
authors: Juliana M
authors: JM
authors: Serpeloni
authors: Ilce M S
authors: IM
authors: Cólus
authors: Wagner
authors: W
authors: Vilegas
authors: Eliana A
authors: EA
authors: Varanda
mesh_terms: D000818:Animals; D002725:Chloroform; D003520:Cyclophosphamide / Q000633:toxicity; D000432:Methanol; D051379:Mice; D015162:Micronucleus Tests; D009153:Mutagens / Q000633:toxicity*; D010936:Plant Extracts / Q000633:toxicity; D018515:Plant Leaves / Q000737:chemistry; D010944:Plants / Q000737:chemistry* / Q000633:toxicity*; D051381:Rats; D012156:Reticulocytes / Q000187:drug effects / Q000648:ultrastructure; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics; D012997:Solvents
chemical_list: D009153:Mutagens; D010936:Plant Extracts; D012997:Solvents; D002725:Chloroform; D003520:Cyclophosphamide; D000432:Methanol