title: Visuospatial working memory in school-aged children exposed in utero to cocaine.
abstract: OBJECTIVE
  Among the neurocognitive impairments reported as associated with prenatal cocaine exposure, slower response time, and less efficient learning in school-aged children are common to findings from several laboratories. This study presents performance data on a spatial working memory task in 75 prenatally cocaine exposed (CE) and 55 nondrug-exposed (NDE) 8- to 10-year-old children.
  
  
  METHODS
  Children were administered a novel neuropsychological measure of immediate- and short-term memory for visuospatial information, the Groton Maze Learning Test (GMLT), a computer-based hidden maze learning test that consists of a "timed chase test" (a simple measure of visuomotor speed), eight learning trials followed by a delayed recall trial after an 8-minute delay and a reverse learning trial. Performance is expressed as correct moves per second and number of errors per trial.
  
  
  RESULTS
  Across all trials, the cocaine-exposed group showed significantly slower correct moves per second and made significantly more errors. There were no significant main effects for amounts of alcohol, tobacco, or marijuana exposure. After an 8-minute delay and compared to the eighth trial, cocaine-exposed children showed less consolidation in learning compared to nonexposed children. When asked to complete the maze in reverse, cocaine-exposed children showed a greater decrement in performance (decreased correct moves per second and increased errors) compared to the eighth learning trial.
  
  
  CONCLUSIONS
  Children exposed in utero to cocaine exhibit a possible impairment in procedural learning and diminished efficiency in creating and accessing an internal spatial map to master the hidden maze.
authors: Yale Child Study Center, Yale University School of Medicine, New Haven, CT 06520, USA.
authors: Linda
authors: L
authors: Mayes
authors: Peter J
authors: PJ
authors: Snyder
authors: Eric
authors: E
authors: Langlois
authors: Nicole
authors: N
authors: Hunter
mesh_terms: D000328:Adult; D002648:Child; D019970:Cocaine-Related Disorders / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male; D008425:Maternal Behavior; D008569:Memory Disorders / Q000175:diagnosis / Q000453:epidemiology*; D008570:Memory, Short-Term; D009483:Neuropsychological Tests; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000453:epidemiology*; D013028:Space Perception; D014796:Visual Perception