Maintenance immunotherapy by repetitive low-dose donor lymphocytes infusions in a child with relapse state aml after allogeneic stem cell transplantation.
The treatment of a child with a relapsed state acute leukemia after allogeneic stem cell transplantation (allo-SCT) is a challenge. The authors report about a child with an acute myelogenous leukemia (AML), which relapsed after allo-SCT despite immunological intervention. It was further treated with a second line chemotherapy followed by an infusion of stem cells and donor lymphocytes. Because of an immense risk for a further relapse, an immunological maintenance therapy was also performed, consisting of repetitive infusions of low doses of donor lymphocytes combined with low-dose chemotherapy. Presently, the child is in continuous complete remission and has a good quality of life.
Hartwig
M
M
Department of Pediatric Oncology and Hematology, University of Greifswald, Greifswald, Germany.
Weigel
S
S
Bernig
T
T
Bader
P
P
Dölken
R
R
Beck
J
J
D001782:Blood Donors; D004306:Dose-Response Relationship, Immunologic; D005260:Female; D006086:Graft vs Host Disease / Q000209:etiology / Q000628:therapy*; D006801:Humans; D007167:Immunotherapy; D007223:Infant; D015470:Leukemia, Myeloid, Acute / Q000150:complications / Q000628:therapy*; D017710:Lymphocyte Transfusion; D009364:Neoplasm Recurrence, Local / Q000628:therapy; D033581:Stem Cell Transplantation; D014184:Transplantation, Homologous; D016896:Treatment Outcome