Drug-supported microparticles of calcium carbonate nanocrystals and its covering with hydroxyapatite.
Drug-supported spherical microparticles with below 3 microm in diameter of calcium carbonate (CC) nanocrystals were precipitated by a complex decomposition method from Na2CO3 and CaCl2 solutions with hydrocortisone phosphate (HyC). The HyC was completely incorporated into the microparticles and was adsorbed on the surface of nanocrystals. The crystal phases of vaterite and calcite were controlled by the addition of magnesium ions. Spherical microparticles of calcite cores and petal-shaped hydroxyapatite (HAp) outer layers were fabricated by soaking calcite into the SBF, or a supersaturated solution of phosphate ions to enhance the crystal growth of HAp.
Ikoma
Toshiyuki
T
National Institute for Materials Science, Biomaterials Center, Namiki 1-1, Tsukuba, Ibaraki 305-0044, Japan.
Tonegawa
Toru
T
Watanaba
Hajime
H
Chen
Guoping
G
Tanaka
Junzo
J
Mizushima
Yutaka
Y
D002119:Calcium Carbonate / Q000737:chemistry*; D016503:Drug Delivery Systems; D017886:Durapatite / Q000737:chemistry*; D006854:Hydrocortisone / Q000008:administration & dosage; D008854:Microscopy, Electron; D008855:Microscopy, Electron, Scanning; D053758:Nanoparticles / Q000737:chemistry / Q000648:ultrastructure; D036103:Nanotechnology; D010316:Particle Size; D017550:Spectroscopy, Fourier Transform Infrared; D014961:X-Ray Diffraction
D017886:Durapatite; D002119:Calcium Carbonate; D006854:Hydrocortisone