Changes in glycaemic control are related to the systolic function in type 1 diabetes mellitus.
OBJECTIVE
To examine whether changes in glycaemic control are related to the left ventricular function, in a group of type 1 diabetic patients.


METHODS
We included 19 consecutive type 1 diabetic patients selected for insulin pump therapy due to poor metabolic control. The outcome measures were HbA1c and systolic left ventricular strain rate as measured by Tissue Doppler echocardiography. Mean follow-up period was 45 days (range 35-50). All patients included had an ejection fraction>55%. None had cardiac symptoms.


RESULTS
The mean age of the participants was 40 years (range 22-65). Following initiation of insulin-pump therapy, the mean HbA1c improved significantly from 8.6+/-1.4% to 7.6+/-1.1% (p<0.01). The mean strain rate of 16 myocardial segments also improved significantly, from -1.58+/-0.30 s-1 to -1.80+/-0.4 s-1 (p<0.01). In addition, there was a significant correlation between the changes in left ventricular function and the changes in HbA1c (delta-Strain rate vs. delta-HbA1c: r=0.49, p<0.01).


CONCLUSIONS
Changes in glycaemic control resulting from insulin pump therapy seem significantly related to the systolic function of the left ventricle.
Andersen
Niels Holmark
NH
Medical Department M (Diabetes & Endocrinology), Aarhus University Hospital, Denmark. holmark@ki.au.dk
Hansen
Troels Krarup
TK
Christiansen
Jens Sandahl
JS
D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000032:analysis*; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000000981:diagnostic imaging / Q000188:drug therapy; D015150:Echocardiography, Doppler; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006801:Humans; D006943:Hyperglycemia / Q000150:complications*; D007332:Insulin Infusion Systems; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013318:Stroke Volume / Q000502:physiology*; D013599:Systole
D001786:Blood Glucose; D006442:Glycated Hemoglobin