HPLC on chiral support with polarimetric detection: application to conglomerate discovery.
In conglomerates, each single crystal contains only one of the two possible enantiomeric forms--either dextrorotatory or levorotatory. The analysis of a single crystal by liquid chromatography on chiral support associated with chiroptical detection is a very efficient tool to reveal the occurrence of a conglomerate. In terms of rapidity and easiness, this method compares favorably with the classical methods used to show this occurrence. Two examples are provided.
Roussel
Christian
C
UMR Chirotechnologies, Catalyse et Biocatalyse, Université Paul Cézanne, 13397 Marseille Cedex 20, France. christian.roussel@univ-cezanne.fr
Vanthuyne
Nicolas
N
Jobert
Jean-Laurent
JL
Loas
Andrei I
AI
Tanase
Anca E
AE
Gherase
Dragos
D