Effect of interleukin-10 on tissue damage caused by organophosphate poisoning.
Organophosphate poisoning is a common cause of severe morbidity and mortality among patients admitted to emergency departments. Tissue damages as a consequence of organophosphate poisoning are frequently reported, but preventing this potentially severe complication has not been the subject of much research. We tested whether interleukin-10, a cytoprotective agent, could prevent or diminish pathological signs of tissue damages caused by organophosphate poisoning. Thirty rats were divided into three equal groups (n = 10). Group 1 (sham) did not receive any agent during the experiment. Group 2 (control) received 0.8 g/kg of fenthion intraperitoneally, followed by 6 ml/kg of intraperitoneal normal saline 30 min and 3 hr later. Group 3 (treatment) received 0.8 g/kg of fenthion intraperitoneally, followed by 2 microg/kg of interleukin-10 intraperitoneally 30 min and 3 hr later. All rats were killed under anaesthesia after 6 hr and tissue samples were obtained from liver, kidneys and lungs. Even organophosphate poisonings do not cause significant clinical problems; several degrees of damages could be observed in liver, kidneys and lungs. These damages could be reduced by interleukin-10 treatment.
Yurumez
Yusuf
Y
Department of Emergency Medicine, Kocatepe University Medical Faculty, Afyon, Turkey.
Ikizceli
Ibrahim
I
Sozuer
Erdogan Mutevelli
EM
Soyuer
Isin
I
Yavuz
Yucel
Y
Avsarogullari
Levent
L
Durukan
Polat
P
D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000473:pathology / Q000517:prevention & control*; D002800:Cholinesterase Inhibitors / Q000506:poisoning*; D004336:Drug Antagonism; D004359:Drug Therapy, Combination; D005260:Female; D005284:Fenthion / Q000506:poisoning*; D007274:Injections, Intraperitoneal; D016753:Interleukin-10 / Q000494:pharmacology*; D007674:Kidney Diseases / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D008171:Lung Diseases / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D051381:Rats; D017208:Rats, Wistar
D002800:Cholinesterase Inhibitors; D016753:Interleukin-10; D005284:Fenthion