title: Bispolides, novel 20-membered ring macrodiolide antibiotics from microbispora.
abstract: Seven new related compounds named bispolides A1, A2, A3, B1, B2a, B2b and B3, have been found in a culture of Microbispora sp. A34030, isolated from a Malaysian soil sample. The planar structures were elucidated to be new 20-membered ring macrodiolide antibiotics on the basis of MS and NMR spectroscopic analyses. These antibiotics showed a good anti-MRSA activity in vitro.
authors: Noriyuki
authors: N
authors: Okujo
authors: Hironobu
authors: H
authors: Iinuma
authors: Annie
authors: A
authors: George
authors: Khor Siew
authors: KS
authors: Eim
authors: Tan Lee
authors: TL
authors: Li
authors: Ng Szu
authors: NS
authors: Ting
authors: Tan Chin
authors: TC
authors: Jye
authors: Kunimoto
authors: K
authors: Hotta
authors: Masahiro
authors: M
authors: Hatsu
authors: Yasuo
authors: Y
authors: Fukagawa
authors: Seiji
authors: S
authors: Shibahara
authors: Keiichi
authors: K
authors: Numata
authors: Shinichi
authors: S
authors: Kondo
mesh_terms: D000192:Actinomycetales / Q000254:growth & development / Q000378:metabolism*; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D018942:Macrolides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D018942:Macrolides; C520925:bispolide A1; C520926:bispolide B1; C520924:bispolide B3