title: [Clinical significance and expression of FLIP and PTEN protein in laryngeal squamous cell carcinoma].
abstract: OBJECTIVE
  To investigate the expression of FLIP and PTEN in laryngeal Squamous cell carcinoma (LSCC), and the relationship between FLIP and PTEN.
  
  
  METHODS
  The protein expression of FLIP and PTEN were examined by using immunohistochemical method in 45 cases of LSCC and 15 cases of para-carcinoma tissues.
  
  
  RESULTS
  FLIP protein positive expressive rate in the laryngeal squamous cell carcinoma cases (77.8%) was higher than that in the para-carcinoma tissues cases (33.3%, P < 0.05). The protein expression of FLIP was correlated with cervical lymph node metastasis, clinical stage and prognosis. On the other hand, PTEN positive expressive rate in the laryngeal squamous cell carcinoma (65.0%) was higher than that in the para-carcinoma tissues (0%, P < 0.01). The protein expression of PTEN was associated with tumor differentiation grade, clinical stage, cervical lymph node metastasis and prognosis. There was a negative relationship between the expression of FLIP and PTEN in LSCC.
  
  
  CONCLUSIONS
  The protein expression of FLIP may be an important prognostic marker for LSCC. The protein expression of PTEN was correlated with clinical stage, tumor differentiation grade, and cervical lymph node metastasis . Consequently, it could be used as a valuable marker for the prognosis of LSCC.
authors: Department of Otolaryngology, Zhongnan Hospital of Wuhan University, Wuhan, China. wzxmax2005@yahoo.com.cn
authors: Zhenxing
authors: Z
authors: Wei
authors: Xiaoqing
authors: X
authors: Jiang
authors: Xuhong
authors: X
authors: Zhou
mesh_terms: D053446:CASP8 and FADD-Like Apoptosis Regulating Protein / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D008207:Lymphatic Metastasis; D009367:Neoplasm Staging; D051059:PTEN Phosphohydrolase / Q000378:metabolism*; D011379:Prognosis
chemical_list: D053446:CASP8 and FADD-Like Apoptosis Regulating Protein; C506386:CFLAR protein, human; D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human