title: Structure of a CBS-domain pair from the regulatory gamma1 subunit of human AMPK in complex with AMP and ZMP.
abstract: AMP-activated kinase (AMPK) is central to sensing energy status in eukaryotic cells via binding of AMP and ATP to CBS (cystathionine beta-synthase) domains in the regulatory gamma subunit. The structure of a CBS-domain pair from human AMPK gamma1 in complex with the physiological activator AMP and the pharmacological activator ZMP (AICAR) is presented.
authors: Astex Therapeutics Ltd, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, England. p.day@astex-therapeutics.com
authors: Philip
authors: P
authors: Day
authors: Andrew
authors: A
authors: Sharff
authors: Lina
authors: L
authors: Parra
authors: Anne
authors: A
authors: Cleasby
authors: Mark
authors: M
authors: Williams
authors: Stefan
authors: S
authors: Hörer
authors: Herbert
authors: H
authors: Nar
authors: Norbert
authors: N
authors: Redemann
authors: Ian
authors: I
authors: Tickle
authors: Jeff
authors: J
authors: Yon
mesh_terms: D000249:Adenosine Monophosphate / Q000737:chemistry*; D000263:Adenylate Kinase / Q000737:chemistry*; D000595:Amino Acid Sequence; D000620:Aminoimidazole Carboxamide / Q000031:analogs & derivatives* / Q000737:chemistry; D003460:Crystallization; D018360:Crystallography, X-Ray; D006801:Humans; D008958:Models, Molecular; D008969:Molecular Sequence Data; D011487:Protein Conformation; D012265:Ribonucleotides / Q000737:chemistry*; D017386:Sequence Homology, Amino Acid
chemical_list: D012265:Ribonucleotides; D000620:Aminoimidazole Carboxamide; D000249:Adenosine Monophosphate; D000263:Adenylate Kinase; C031143:AICA ribonucleotide