Urukthapelstatin A, a novel cytotoxic substance from marine-derived Mechercharimyces asporophorigenens YM11-542. II. Physico-chemical properties and structural elucidation.
The new cyclic peptide antibiotic, urukthapelstatin A, has been isolated from a culture of Thermoactinomycetaceae bacterium Mechercharimyces asporophorigenens YM11-542. The structure of urukthapelstatin A was elucidated by NMR, MS, Marfey analysis, chiral HPLC and X-ray crystal analyses.
Matsuo
Yoshihide
Y
Marine Biotechnology Institute Co. Ltd.
Kanoh
Kaneo
K
Imagawa
Hiroshi
H
Adachi
Kyoko
K
Nishizawa
Mugio
M
Shizuri
Yoshikazu
Y
D000903:Antibiotics, Antineoplastic / Q000737:chemistry*; D018360:Crystallography, X-Ray; D016936:Gram-Positive Endospore-Forming Bacteria / Q000378:metabolism*; D007930:Leucine / Q000031:analogs & derivatives* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D013844:Thiazoles / Q000737:chemistry*; D014871:Water Microbiology
D000903:Antibiotics, Antineoplastic; D013844:Thiazoles; C521435:urukthapelstatin A; D007930:Leucine