[Expression of PML in carcinogenesis of laryngocarcinoma and nasopharyngeal carcinoma].
OBJECTIVE
To explore the significance of PML expression in carcinogenesis of laryngocarcinoma and nasopharyngeal carcinoma.


METHODS
The PML expression in 56 laryngocarcinoma tissues and 34 nasopharyngeal carcinoma tissues were examined by immunohistochemistry. Moreover, the relationship between the PML expression, with the pathologic grade,T stage and lymph node metastasis was analyzed.


RESULTS
The PML expression decreased with the ascending of pathological tumor grade (P < 0.05) and with the increasing of T grade of tumor (P < 0.05). The expression of PML in nasopharyngeal carcinoma was lower than that in carcinoma of larynx (P < 0.05). However, either in laryngocarcinoma or in nasopharyngeal carcinoma, there was no statistical difference on PML expression between with and without lymph node metastasis in laryngo carcinoma tissues and nasopharyngeal carcinoma tissues.


CONCLUSIONS
The close relationship between PML expression and the malignant parameters such as pathological grade and T grade of laryngocarcinoma and nasopharyngeal carcinoma, indicated that PML may play a role in cancer repression but not in cancer metastasis.
Chen
Wei
W
Department of Otolaryngology-Head and Neck Surgery, the People's Hospital of Wuhan University, Wuhan, China.
Yao
Wei
W
Chen
Shiming
S
Xiao
Bokui
B
Tao
Zezhang
Z
D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism*; D000071156:Promyelocytic Leukemia Protein; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*; D025521:Tumor Suppressor Proteins / Q000235:genetics / Q000378:metabolism*
D009687:Nuclear Proteins; D000071156:Promyelocytic Leukemia Protein; D014157:Transcription Factors; D025521:Tumor Suppressor Proteins; C070576:PML protein, human