B-cell lymphoma in a dog with ehrlichiosis (Ehrlichia canis) and systemic histoplasmosis (Histoplasma capsulatum).
A mixed breed dog treated for ehrlichiosis and systemic histoplasmosis developed a refractory thrombocytopenia. When an abdominal mass was detected, exploratory laparotomy and biopsies confirmed lymphoma, which on immunohistochemical stains was determined to be of B-cell origin. Conceivably, the B-cell lymphoma in this dog was associated with chronic inflammation from ehrlichiosis, histoplasmosis, or both.
Brunker
Jill D
JD
Department of Veterinary Clinical Sciences, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, Oklahoma 74078, USA. jill.brunker@okstate.edu
Hoover
John P
JP
D000008:Abdominal Neoplasms / Q000209:etiology / Q000473:pathology / Q000601:surgery / Q000662:veterinary*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use; D004283:Dog Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D004285:Dogs; D041061:Ehrlichia canis; D016873:Ehrlichiosis / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000662:veterinary*; D017809:Fatal Outcome; D005260:Female; D006658:Histoplasma / Q000302:isolation & purification; D006660:Histoplasmosis / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000662:veterinary*; D016393:Lymphoma, B-Cell / Q000209:etiology / Q000473:pathology / Q000601:surgery / Q000662:veterinary*; D013921:Thrombocytopenia / Q000175:diagnosis / Q000209:etiology / Q000473:pathology / Q000662:veterinary
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D000970:Antineoplastic Agents