Serum surfactant protein D is correlated to development of dementia and augmented mortality.
Development of dementia, including Alzheimer's disease (AD), is associated with lipid dysregulation and inflammation. As the host defense lectin surfactant protein D (SP-D) has multiple effects in lipid homeostasis and inflammation, the correlation between SP-D concentrations and development of dementia was investigated. A total of 418 non-demented persons were included in the study and cognitively re-examined after 3 years, while survival was followed for 11 years. Serum SP-D concentrations were measured at baseline. Logistic regression analysis controlling for age, gender, smoking status, and CRP showed that Odds Ratio for developing dementia was 2.62 (1.12-6.15) with an SP-D concentration in the highest quartile compared to the other quartiles. The risk of AD was 2.55 (0.95-6.90). Cox regression controlling for the same variables showed that hazard ratio of death was 1.43 (1.06-1.92) in the highest quartile. SP-D concentration thus correlates to development of dementia as well as to augmented mortality.
Nybo
Mads
M
Department of Biochemistry, Pharmacology and Genetics, Odense University Hospital, Odense, Denmark. mads.nybo@ouh.regionsyddanmark.dk
Andersen
Kjeld
K
Sorensen
Grith L
GL
Lolk
Anette
A
Kragh-Sorensen
Per
P
Holmskov
Uffe
U
D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000097:blood / Q000401:mortality; D002097:C-Reactive Protein / Q000032:analysis; D003704:Dementia / Q000097:blood* / Q000401:mortality; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016015:Logistic Models; D008297:Male; D016017:Odds Ratio; D016016:Proportional Hazards Models; D037663:Pulmonary Surfactant-Associated Protein D / Q000097:blood*; D012307:Risk Factors; D012737:Sex Factors; D012907:Smoking; D013053:Spectrophotometry / Q000706:statistics & numerical data; D016019:Survival Analysis; D015996:Survival Rate
D037663:Pulmonary Surfactant-Associated Protein D; D002097:C-Reactive Protein