Intracranial aneurysm associated with chronic mucocutaneous candidiasis.
Chronic mucocutaneous candidiasis (CMC) is a syndrome characterised by immune deficiency, often presenting familial dominant inheritance and association with autoimmune endocrinopathies. We report on a patient with CMC who died at 5 years of age of a brain haemorrhage following the rupture of a basilar-artery aneurysm. Candida hyphae in the basilar artery were found at autopsy. A common immunologic abnormality in CMC is the failure of patient's T-lymphocytes to produce cytokines, which are essential for expression of cell-mediated immunity to Candida. Therefore, long-term treatment is mandatory.
Marazzi
M G
MG
Infectious Diseases Department, Giannina Gaslini Institute, University of Genoa, Largo Gerolamo Gaslini, 5-16147, Genoa, Italy. mgraziamarazzi@ospedale-gaslini.ge.it
Bondi
E
E
Giannattasio
A
A
Strozzi
M
M
Savioli
C
C
D002178:Candidiasis, Chronic Mucocutaneous / Q000150:complications* / Q000175:diagnosis; D002533:Cerebral Angiography; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D006801:Humans; D007223:Infant; D002532:Intracranial Aneurysm / Q000175:diagnosis / Q000209:etiology*; D008297:Male; D014057:Tomography, X-Ray Computed