Structures of new cytotoxic antibiotics, piericidins C7 and C8.
Two new cytotoxic antibiotics, piericidins C7 (1) and C8 (2), were isolated from a marine Streptomyces sp. High-resolution FAB-MS established the molecular formulae of 1 and 2 as C28H41NO5 and C29H43NO5, respectively. The planar structures of the piericidins were elucidated by NMR spectral analysis including COSY, HMQC and HMBC. The relative stereochemistry of 2 was determined based on NOESY and coupling constant analyses. 1 and 2 are new members of the piericidin family possessing 11,12-epoxide and 12-butenyl groups.
Hayakawa
Yoichi
Y
Faculty of Pharmaceutical Sciences, Tokyo University of Science, Noda, Chiba, Japan. hykw@rs.noda.tus.ac.jp
Shirasaki
Shingo
S
Kawasaki
Takashi
T
Matsuo
Yoshihide
Y
Adachi
Kyoko
K
Shizuri
Yoshikazu
Y
D000903:Antibiotics, Antineoplastic / Q000737:chemistry*; D004852:Epoxy Compounds / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D011725:Pyridines / Q000737:chemistry*; D013237:Stereoisomerism; D013302:Streptomyces / Q000378:metabolism*
D000903:Antibiotics, Antineoplastic; D004852:Epoxy Compounds; D011725:Pyridines