Methods of measuring insulin sensitivity.
Insulin resistance is a component of several health disorders, most notably impaired glucose tolerance and type 2 diabetes mellitus. Insulin-resistant individuals have an impaired biological response to the usual action of insulin; that is, they have reduced insulin sensitivity. Various methods are used to assess insulin sensitivity both in individuals and in study populations. Validity, reproducibility, cost, and degree of subject burden are important factors for both clinicians and researchers to consider when weighing the merits of a particular method. This article describes several in vivo methods used to assess insulin sensitivity and presents the advantages and disadvantages of each.
Trout
Kimberly K
KK
Villanova University College of Nursing, Villanova, Pennsylvania 19085, USA. kimberly.trout@villanova.edu
Homko
Carol
C
Tkacs
Nancy C
NC
D003362:Cost-Benefit Analysis; D003924:Diabetes Mellitus, Type 2 / Q000175:diagnosis* / Q000378:metabolism; D003940:Diagnostic Techniques, Endocrine / Q000191:economics / Q000592:standards; D015309:Glucose Clamp Technique / Q000379:methods; D018149:Glucose Intolerance / Q000175:diagnosis* / Q000378:metabolism; D005951:Glucose Tolerance Test / Q000379:methods; D006442:Glycated Hemoglobin; D006706:Homeostasis; D006801:Humans; D007328:Insulin / Q000502:physiology; D007333:Insulin Resistance / Q000502:physiology*; D019518:Postprandial Period / Q000502:physiology; D015203:Reproducibility of Results
D006442:Glycated Hemoglobin; D007328:Insulin