title: [Iron metabolism in biological systems (biochemical, pathophysiological and clinical aspects)].
abstract: Modern concepts concerning iron metabolisms in the body, its circulation, involvement into free radical processes and lipid peroxidation (LP) are reviewed. Spetial attention is paid to cytotoxic effects, Fe2+ influence on lipid peroxidation, its role in multiple organ failure development in critical states. Iron ion can be bound by desferal, which may be effectively used for intensive care of critical states.
authors: Iu P
authors: IuP
authors: Orlov
authors: V T
authors: VT
authors: Dolgikh
mesh_terms: D000975:Antioxidants / Q000627:therapeutic use; D016638:Critical Illness; D003676:Deferoxamine / Q000627:therapeutic use; D005609:Free Radicals / Q000378:metabolism; D006801:Humans; D000860:Hypoxia / Q000378:metabolism; D007501:Iron / Q000378:metabolism*; D035925:Iron-Regulatory Proteins / Q000502:physiology; D015227:Lipid Peroxidation; D009102:Multiple Organ Failure / Q000188:drug therapy / Q000378:metabolism*; D010084:Oxidation-Reduction; D017262:Siderophores / Q000627:therapeutic use
chemical_list: D000975:Antioxidants; D005609:Free Radicals; D035925:Iron-Regulatory Proteins; D017262:Siderophores; D007501:Iron; D003676:Deferoxamine