[Non Hodgkin's lymphoma in adolescents].
In France, adolescents (15-20 years) with non Hodgkin's lymphoma (NHL) are referred either to paediatric or to adult onco-haematological departments. According to data obtained from regional tumour registries (covering about 10% of France), their 5 year survival rate was 59% whereas it was 87% for children (< or =14 years) treated for NHL during a similar period of time. We reviewed the management of NHL either by the paediatricians or the onco-hematologists for adults. The categories of NHL that are reviewed and whose clinical and biological characteristics are presented are: Burkitt, lymphoblastic and large cell, either B or anaplastic. This review shows that, in most series, outcome was better in children than in adults. This raises the reasons of this difference: is it due to the different therapeutic approaches, to different tolerance of chemotherapy, to different biology within the same histological type ? Further studies specific to the adolescents are needed to better know the biology of their lymphoma and to determine the best therapeutic approach.
Patte
Catherine
C
Département de pédiatrie, Institut Gustave-Roussy, rue Camille-Desmoulins, 94800 Villejuif. patte@igr.fr
Ribrag
Vincent
V
Brugières
Laurence
L
D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000367:Age Factors; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002051:Burkitt Lymphoma / Q000188:drug therapy / Q000401:mortality; D002648:Child; D002985:Clinical Protocols; D005602:France / Q000453:epidemiology; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000188:drug therapy / Q000401:mortality; D008228:Lymphoma, Non-Hodgkin / Q000145:classification / Q000188:drug therapy* / Q000401:mortality; D008495:Medical Oncology / Q000458:organization & administration; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy / Q000401:mortality