title: Efficient co-crystal screening using solution-mediated phase transformation.
abstract: We have extended the established physical stability treatment for hydrates/solvates to co-crystals with solid co-crystal formers. Based on the proposed treatment, a suspension/slurry screening technique is developed and tested in sixteen pharmaceutical co-crystal systems with success. The theoretical treatment and the practical screening technique should benefit the researchers in the field of co-crystallization in improving the screening efficiency.
authors: Geoff G Z
authors: GG
authors: Zhang
authors: Rodger F
authors: RF
authors: Henry
authors: Thomas B
authors: TB
authors: Borchardt
authors: Xiaochun
authors: X
authors: Lou
mesh_terms: D002626:Chemistry, Pharmaceutical; D003460:Crystallization; D004355:Drug Stability; D008956:Models, Chemical; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D044367:Phase Transition; D012996:Solutions; D013678:Technology, Pharmaceutical / Q000379:methods*; D014867:Water
chemical_list: D004364:Pharmaceutical Preparations; D012996:Solutions; D014867:Water