title: A correlative study of ultrasound with serology in an area in China co-endemic for human alveolar and cystic echinococcosis.
abstract: We correlated ultrasound (US) imaging classifications for human alveolar echinococcosis (AE) and cystic echinococcosis (CE) with serology (ELISA and immunoblotting (IB) incorporating native and recombinant/purified echinococcal antigens) in community surveys (2001-2003) and follow-up (2002 and 2003) of US-confirmed cases in Ningxia, China. One hundred and seventy-one cases (96 with AE, 75 with CE) were identified; of these, US classification and serological data were obtained for 142 and 112 cases, respectively. Seropositive-rates increased in CE patients with highly viable unilocular cyst lesions (Types CL, CE 1 or CE 2) to degenerating primary lesions (CE 3), but then decreased in subjects with inactive (CE 4) or dead (CE 5) cysts. In contrast, there was a constant increase in seropositivity from the early (P1, P2) to the advanced stages (P3, P4) with AE cases. For US-confirmed cases, follow-up by US combined with serology is invaluable for studying the clinical progression of echinococcosis and for detecting recurrent cysts or reinfection post-treatment.
authors: Ningxia Medical College, Yinchuan, Ningxia Hui Autonomous Region, China.
authors: Y R
authors: YR
authors: Yang
authors: P S
authors: PS
authors: Craig
authors: A
authors: A
authors: Ito
authors: D A
authors: DA
authors: Vuitton
authors: P
authors: P
authors: Giraudoux
authors: T
authors: T
authors: Sun
authors: G M
authors: GM
authors: Williams
authors: Z
authors: Z
authors: Huang
authors: Z
authors: Z
authors: Li
authors: Y
authors: Y
authors: Wang
authors: J
authors: J
authors: Teng
authors: Y
authors: Y
authors: Li
authors: L
authors: L
authors: Huang
authors: H
authors: H
authors: Wen
authors: M K
authors: MK
authors: Jones
authors: D P
authors: DP
authors: McManus
mesh_terms: D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D015897:Comorbidity; D003429:Cross Reactions / Q000276:immunology; D004443:Echinococcosis / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000276:immunology; D004444:Echinococcosis, Hepatic / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000276:immunology; D004445:Echinococcosis, Pulmonary / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000276:immunology; D019353:Endemic Diseases; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005260:Female; D006801:Humans; D015151:Immunoblotting / Q000379:methods; D008297:Male; D008875:Middle Aged; D011159:Population Surveillance / Q000379:methods; D011650:Pulmonary Alveoli / Q000000981:diagnostic imaging / Q000276:immunology; D014463:Ultrasonography