title: The impact of nodal isolated tumor cells on survival of breast cancer patients.
abstract: BACKGROUND
  Isolated tumor cells (ITCs), often detectable only with immunohistochemical techniques, have an unknown significance in the prognosis of breast cancer. The American Joint Committee on Cancer guidelines classify such patients as N0 (immunohistochemistry +), staging them with node-negative patients. We sought to further elucidate the impact of ITCs on survival.
  
  
  METHODS
  We conducted a retrospective review of all women at our institution with breast cancer from 1996 to 2005. Of 514 patients, 16 had isolated tumor cells detected only with immunohistochemical staining. Survival then was compared with historical survival rates for women with node-free disease.
  
  
  RESULTS
  The 16 women with N0 (i+) disease had stage I or II disease. There was no documented recurrence among these women, with an average follow-up period of 2.5 years.
  
  
  CONCLUSIONS
  Our data suggest that ITCs detected in lymph nodes do not adversely impact survival or disease-free survival compared with women with node-negative disease. Larger studies will be required to confirm these findings.
authors: Department of Surgery, Madigan Army Medical Center, 9040A Reid St., Tacoma, WA 98431, USA. garth.herbert@gmail.com
authors: Garth S
authors: GS
authors: Herbert
authors: Vance Y
authors: VY
authors: Sohn
authors: Tommy A
authors: TA
authors: Brown
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000401:mortality* / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008207:Lymphatic Metastasis; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D021701:Sentinel Lymph Node Biopsy; D015996:Survival Rate