Efficient co-crystal screening using solution-mediated phase transformation.
We have extended the established physical stability treatment for hydrates/solvates to co-crystals with solid co-crystal formers. Based on the proposed treatment, a suspension/slurry screening technique is developed and tested in sixteen pharmaceutical co-crystal systems with success. The theoretical treatment and the practical screening technique should benefit the researchers in the field of co-crystallization in improving the screening efficiency.
Zhang
Geoff G Z
GG
Henry
Rodger F
RF
Borchardt
Thomas B
TB
Lou
Xiaochun
X
D002626:Chemistry, Pharmaceutical; D003460:Crystallization; D004355:Drug Stability; D008956:Models, Chemical; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D044367:Phase Transition; D012996:Solutions; D013678:Technology, Pharmaceutical / Q000379:methods*; D014867:Water
D004364:Pharmaceutical Preparations; D012996:Solutions; D014867:Water