Comparison of two doses of metformin (2.5 and 1.5 g/day) for the treatment of polycystic ovary syndrome and their effect on body mass index and waist circumference.
Fifty-six women with body mass index (BMI) greater than 27 were randomly divided into two groups receiving different doses of metformin (2.5 g and 1.5 g/day) for the treatment of polycystic ovary syndrome to assess its effects on BMI and waist circumference. Although after 6 months of treatment both groups had a significant reduction in those indices, the intergroup variation proved the higher dose to be more efficient.
Bruno
Ricardo Vasconcellos
RV
Instituto de Ginecologia da Universidade Federal do Rio de Janeiro, Brazil. ricardovbruno@terra.com.br <ricardovbruno@terra.com.br>
de Avila
Márcio Augusto Pinto
MA
Neves
Fernanda Baleeiro
FB
Nardi
Antonio Egidio
AE
Crespo
Clícia Márcia Santos
CM
Sobrinho
Antonio Tavares Carneiro
AT
D000328:Adult; D015992:Body Mass Index; D001835:Body Weight / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage; D007333:Insulin Resistance; D008687:Metformin / Q000008:administration & dosage*; D011085:Polycystic Ovary Syndrome / Q000188:drug therapy*; D049629:Waist-Hip Ratio
D007004:Hypoglycemic Agents; D008687:Metformin