In vivo antimalarial activity of isosungucine, an indolomonoterpenic alkaloid from Strychnos icaja.
Isosungucine (1) is a quasi-symmetric bisindolomonoterpenoid alkaloid isolated from the roots of Strychnos icaja. The in vivo antimalarial activity against the P. vinckei petteri murine strain was determined. In the Peters 4-day suppressive test, 1 suppressed the parasitemia by almost 50 percent on day 4 at the dose of 30 mg/kg by intraperitoneal route.
Philippe
Geneviève
G
University of Liège, Drug Research Center, Laboratory of Pharmacognosy, Liège, Belgium.
De Mol
Patrick
P
Angenot
Luc
L
Tits
Monique
M
Frédérich
Michel
M
D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D005260:Female; D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D051379:Mice; D010961:Plasmodium / Q000187:drug effects; D031451:Strychnos / Q000737:chemistry*
D000962:Antimalarials; D026121:Indole Alkaloids; C464957:isosungucine