title: Renal tumour size measured radiologically before surgery is an unreliable variable for predicting histopathological features: benign tumours are not necessarily small.
abstract: OBJECTIVE
  To compare histopathological findings as a function of radiological tumour size, as published data suggest that small renal tumours are often benign and large tumours are renal cell cancer (RCC).
  
  
  METHODS
  Data from 543 surgically treated patients with solid renal tumours were analysed retrospectively. Tumour size measured by computed tomography (CT) before surgery was stratified into seven subgroups (cm): 0-2, 2.1-3, 3.1-4, 4.1-5, 5.1-6, 6.1-7 and >7, and correlated with final histology.
  
  
  RESULTS
  In all, 80 lesions (14.7%) were benign on final histology; tumour size did not correlate with benign histology (P=0.660). Histopathological tumour size was not statistically significant different (P=0.521) from measured tumour size on CT, and there was no statistical significance between CT and histopathological tumour size (P=0.528). Only 13 (17%) of lesions were correctly defined as benign on CT before surgery, whereas 67 (83%) were considered to be suspicious for malignant disease. Only one patient with a tumour correctly defined as benign had a radical nephrectomy; by contrast, 28 of 67 (42%) had a radical nephrectomy for benign lesions not correctly identified as benign on CT before surgery (P<0.001).
  
  
  CONCLUSIONS
  Substantially many renal masses are benign, independent of tumour size. Radical nephrectomy could potentially have been avoided in 42% of patients with benign renal tumours. These data provide a good argument for the use of a more refined preoperative diagnostic evaluation, in particular needle biopsy.
authors: Department of Urology, Medical University of Vienna, Vienna, Austria. mRemzi@gmx.at
authors: Mesut
authors: M
authors: Remzi
authors: Daniela
authors: D
authors: Katzenbeisser
authors: Matthias
authors: M
authors: Waldert
authors: Hans-Christoph
authors: HC
authors: Klingler
authors: Martin
authors: M
authors: Susani
authors: Mazda
authors: M
authors: Memarsadeghi
authors: Gertraud
authors: G
authors: Heinz-Peer
authors: Andrea
authors: A
authors: Haitel
authors: Ralf
authors: R
authors: Herwig
authors: Michael
authors: M
authors: Marberger
mesh_terms: D000368:Aged; D001707:Biopsy, Needle; D006801:Humans; D007668:Kidney / Q000000981:diagnostic imaging / Q000473:pathology*; D007680:Kidney Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D008875:Middle Aged; D009392:Nephrectomy / Q000706:statistics & numerical data; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed / Q000592:standards*