Lithium, arginine vasopressin and the dex/CRH test in mood disordered patients.
The impact of lithium on arginine vasopressin (AVP) release has implications for our understanding of the pathophysiology and treatment of mood disorders and for the interpretation of neuroendocrine studies. In this secondary analysis of neuroendocrine, data from 23 patients with chronic major depressive disorder, 41 patients with bipolar disorder and 18 healthy controls, we examine the relationship between lithium therapy, AVP levels and the cortisol response to the dexamethasone/corticotropin-releasing hormone (dex/CRH) test. These data demonstrate that patients taking lithium have elevated post-dexamethasone AVP levels compared to both healthy controls and patients not on lithium.
Watson
Stuart
S
The Stanley Research Centre, School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, UK. stuart.watson@ncl.ac.uk
Gallagher
Peter
P
Smith
Margaret S
MS
Young
Allan H
AH
Ferrier
I Nicol
IN
D000328:Adult; D000928:Antidepressive Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001127:Arginine Vasopressin / Q000097:blood / Q000187:drug effects*; D001714:Bipolar Disorder / Q000097:blood* / Q000188:drug therapy / Q000503:physiopathology; D016022:Case-Control Studies; D003346:Corticotropin-Releasing Hormone / Q000008:administration & dosage; D003865:Major Depressive Disorder / Q000097:blood* / Q000188:drug therapy / Q000503:physiopathology; D003907:Dexamethasone / Q000008:administration & dosage; D005260:Female; D006728:Hormones / Q000008:administration & dosage; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects / Q000503:physiopathology; D018020:Lithium Compounds / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D016555:Matched-Pair Analysis; D008875:Middle Aged; D010913:Pituitary-Adrenal System / Q000187:drug effects / Q000503:physiopathology; D012016:Reference Values; D013268:Stimulation, Chemical
D000928:Antidepressive Agents; D006728:Hormones; D018020:Lithium Compounds; D001127:Arginine Vasopressin; D003907:Dexamethasone; D003346:Corticotropin-Releasing Hormone; D006854:Hydrocortisone