Genetic determination in onset age of wrist fracture.
The onset age of fracture may be useful to explore the clinical and genetic heterogeneity of fracture study. In the present study, we investigated the heritability of the onset age of wrist fracture (OAWF) in 30 female full-sib pairs. The phenotypic correlation coefficient of OAWF was 0.309 (P=0.09) for this cohort of female sib pairs, and the narrow-sense heritability (h2) was estimated to be 0.618 (P=0.09). In addition, the h2 derived from the variance component model implemented in SOLAR was 0.722 (P<0.05). This study, for the very first time, suggested that OAWF is under genetic control and thus potentially helps clarify genetic heterogeneity of wrist fracture.
Xiong
Donghai
D
The Key Laboratory of Biomedical Information Engineering of the Ministry of Education and Institute of Molecular Genetics, Xi'an Jiaotong University, Xi'an, Shaanxi, 710049, People's Republic of China.
Wang
Wei
W
The Key Laboratory of Biomedical Information Engineering of the Ministry of Education and Institute of Molecular Genetics, Xi'an Jiaotong University, Xi'an, Shaanxi, 710049, People's Republic of China.|Osteoporosis Research Center and Department of Biomedical Sciences, Creighton University, Omaha, NE, 68131, USA.
Chen
Yuan
Y
Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan, 410081, People's Republic of China.
Jiang
Hui
H
Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan, 410081, People's Republic of China.
Deng
Hong-Wen
HW
The Key Laboratory of Biomedical Information Engineering of the Ministry of Education and Institute of Molecular Genetics, Xi'an Jiaotong University, Xi'an, Shaanxi, 710049, People's Republic of China. dengh@umkc.edu.|M3-CO3 Medical School, School of Medicine, University of Missouri-Kansas City, 2411 Holmes Street, Kansas City, MO, 64108, USA. dengh@umkc.edu.|Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan, 410081, People's Republic of China. dengh@umkc.edu.
D017668:Age of Onset; D000368:Aged; D015331:Cohort Studies; D005260:Female; D050723:Fractures, Bone / Q000453:epidemiology / Q000235:genetics*; D018740:Genetic Heterogeneity; D020022:Genetic Predisposition to Disease; D006801:Humans; D016014:Linear Models; D010024:Osteoporosis / Q000453:epidemiology / Q000235:genetics*; D014954:Wrist Injuries / Q000453:epidemiology / Q000235:genetics*