Effect of the aqueous extract of Syzygium cumini on carbon tetrachloride-induced hepatotoxicity in rats.
The aim of this study was to evaluate the effect of the aqueous Syzygium cumini leaf extract, given either as a single dose or by 7 days of pretreatment, on hepatotoxicity induced by carbon tetrachloride in rats. Blood samples obtained after treatments were measured for aspartate aminotransferase (AST) and alanine aminotransferase (ALT). A significant increase in the AST and ALT activities occurred after carbon tetrachloride administration alone, which was significantly lowered by preadministration with the aqueous extract of Syzygium cumini, but not by a single dose. This suggests that the extract may be useful for liver protection but needs to be given over a significant period and prior to liver injury.
Moresco
Rafael Noal
RN
Departamento de Análises Clínicas e Toxicológicas, Centro de Ciências da Saúde, Universidade Federal de Santa Maria, Santa Maria-RS, Brazil. rnmoresco@yahoo.com.br
Sperotto
Rita Leal
RL
Bernardi
Anie Schiavo
AS
Cardoso
Ricardo França
RF
Gomes
Patrícia
P
D000818:Animals; D002251:Carbon Tetrachloride / Q000633:toxicity; D002252:Carbon Tetrachloride Poisoning / Q000188:drug therapy*; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy*; D008297:Male; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D027842:Syzygium / Q000737:chemistry*; D014867:Water
D010936:Plant Extracts; D014867:Water; D002251:Carbon Tetrachloride