title: [Modulation of programmed death of the peripheral blood lymphocytes under chronic virus infection].
abstract: We investigated programmed death of lymphocytes in patients with chronic infections--tick-borne encephalitis, hepatitis B and C. It has been shown that the character of disorders in realization of lymphocyte apoptosis depends on molecular features of the infectious agent. Apoptotic death of lymphocytes was elevated after incubation in vitro with dexamethazone, etopozide and in medium without serum. Receptor-dependent and mitochondrial paths of apoptotic signal conduction are preferentially modulated under chronic virus persistence.
authors: O B
authors: OB
authors: Zhukova
authors: N V
authors: NV
authors: Riazantseva
authors: V V
authors: VV
authors: Novitskiĭ
authors: T T
authors: TT
authors: Radzivil
authors: L S
authors: LS
authors: Litvinova
authors: N Iu
authors: NIu
authors: Chasovskikh
mesh_terms: D017209:Apoptosis; D002478:Cells, Cultured; D002908:Chronic Disease; D003907:Dexamethasone / Q000494:pharmacology; D004675:Encephalitis, Tick-Borne / Q000503:physiopathology*; D005047:Etoposide / Q000494:pharmacology; D019694:Hepatitis B, Chronic / Q000503:physiopathology*; D019698:Hepatitis C, Chronic / Q000503:physiopathology*; D006801:Humans; D007963:Leukocytes, Mononuclear; D008214:Lymphocytes / Q000473:pathology*; D008564:Membrane Potentials; D008928:Mitochondria / Q000502:physiology; D018124:Receptors, Tumor Necrosis Factor / Q000378:metabolism; D019014:fas Receptor / Q000378:metabolism
chemical_list: D018124:Receptors, Tumor Necrosis Factor; D019014:fas Receptor; D005047:Etoposide; D003907:Dexamethasone