Onset of protection from experimental infection with type 2 bovine viral diarrhea virus following vaccination with a modified-live vaccine.
The onset of protection after the administration of a modified-live bovine viral diarrhea virus (BVDV) vaccine was determined. Protection was determined following experimental infection with a virulent type-2 BVDV (strain 1373) in cattle vaccinated 3, 5, or 7 days before BVDV infection. Protection, as measured by reduced virus shedding, lack of leukopenia, reduction in viremia, and reduced mortality, was present as early as 3 days after vaccination with a single dose of modified-live BVDV vaccine. Complete protection was obtained in cattle vaccinated 5 or 7 days before BVDV experimental infection.
Brock
K V
KV
Department of Pathobiology, College of Veterinary Medicine, Auburn University, AL 36849, USA.
Widel
P
P
Walz
P
P
Walz
H L
HL
D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D001912:Bovine Virus Diarrhea-Mucosal Disease / Q000276:immunology / Q000517:prevention & control*; D002417:Cattle; D002418:Cattle Diseases / Q000276:immunology / Q000517:prevention & control*; D030242:Diarrhea Virus 2, Bovine Viral / Q000276:immunology*; D007279:Injections, Subcutaneous; D008297:Male; D014613:Vaccines, Attenuated / Q000008:administration & dosage / Q000627:therapeutic use; D014765:Viral Vaccines / Q000008:administration & dosage / Q000627:therapeutic use*; D017201:Virus Shedding
D000914:Antibodies, Viral; D014613:Vaccines, Attenuated; D014765:Viral Vaccines