title: Dental amalgam restorations and children's neuropsychological function: the New England Children's Amalgam Trial.
abstract: BACKGROUND
  A concern persists that children's exposure to mercury vapor from dental amalgams produces neurotoxicity.
  
  
  OBJECTIVE
  Our goal was to compare the neuropsychological function of children, without prior exposure to dental amalgam, whose caries were repaired using either dental amalgam or mercury-free composite materials.
  
  
  METHODS
  We conducted a randomized controlled trial involving 534 6- to 10-year-old urban and rural children who were assessed yearly for 5 years using a battery of tests of intelligence, achievement, language, memory, learning, visual-spatial skills, verbal fluency, fine motor function, problem solving, attention, and executive function.
  
  
  RESULTS
  Although the mean urinary mercury concentration was greater among children in the amalgam group than the composite group (0.9 vs. 0.6 microg/g creatinine), few significant differences were found between the test scores of children in the two groups. The differences found were inconsistent in direction. Analyses using two cumulative exposure indices--surface years of amalgam and urinary mercury concentration--produced similar results.
  
  
  CONCLUSIONS
  Exposure to elemental mercury in amalgam at the levels experienced by the children who participated in the trial did not result in significant effects on neuropsychological function within the 5-year follow-up period.
authors: Department of Neurology, Children's Hospital Boston and Harvard Medical, Harvard School of Public Health, Boston, Massachusetts, USA.
authors: David C
authors: DC
authors: Bellinger
authors: David
authors: D
authors: Daniel
authors: Felicia
authors: F
authors: Trachtenberg
authors: Mary
authors: M
authors: Tavares
authors: Sonja
authors: S
authors: McKinlay
mesh_terms: D002648:Child; D003723:Dental Amalgam / Q000633:toxicity*; D005260:Female; D006801:Humans; D008281:Maine; D008297:Male; D008404:Massachusetts; D008628:Mercury / Q000633:toxicity*; D009483:Neuropsychological Tests
chemical_list: D003723:Dental Amalgam; D008628:Mercury