title: [Successful therapy of ulcerated necrobiosis lipoidica non diabeticorum with cyclosporine A].
abstract: Necrobiosis lipoidica is an inflammatory granulomatous skin disease of unknown etiology which is associated with diabetes mellitus in about 60% of the patients. In 15-35% of the affected patients painful ulcerations may occur after minimal trauma which can be extremely refractory to therapy. Because of the unknown pathomechanisms, current therapeutic options are limited. We report on a 68-year-old patient with an 18 year history of ulcerated necrobiosis lipoidica non diabeticorum of both lower limbs, which responded to systemic cyclosporine A. Based on this case, we discuss the role of cyclosporine A in patients with necrobiosis lipoidica in the context of the disease etiology.
authors: Klinik und Poliklinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum Essen, Essen, Deutschland.
authors: E
authors: E
authors: Aslan
authors: A
authors: A
authors: Körber
authors: S
authors: S
authors: Grabbe
authors: J
authors: J
authors: Dissemond
mesh_terms: D000368:Aged; D003131:Combined Modality Therapy; D016572:Cyclosporine / Q000627:therapeutic use*; D003646:Debridement; D003937:Diagnosis, Differential; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D007871:Leg Ulcer / Q000175:diagnosis / Q000188:drug therapy* / Q000601:surgery; D009335:Necrobiosis Lipoidica / Q000175:diagnosis / Q000188:drug therapy* / Q000601:surgery; D012008:Recurrence; D019233:Retreatment
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine