title: Changes in the spleen and liver of pregnant sows and full-term piglets after feeding diets naturally contaminated with deoxynivalenol and zearalenone.
abstract: Wheat contaminated naturally with the Fusarium toxins deoxynivalenol (DON) and zearalenone (ZON) was fed to pregnant Landrace sows for 35days. On day 110, caesarean section was carried out, the offspring were killed immediately after birth, and their livers and spleens examined. At necropsy there were no macroscopic lesions observed in any organ of either sows or piglets. Histopathological evaluation of tissues from sows of the treated group revealed changes in liver and spleen tissues, whereas no significant changes were observed in these tissues in their piglets. Liver damage, as measured by prominent elevated transaminase activities, was not detected in the serum of the sows. In pregnant sows there were individual variations in sensitivity to the Fusarium toxins. In conclusion, it can be assumed that there are no adverse effects on the liver and spleen of full-term piglets when their mothers consumed diets containing up to 9570 and 358mug DON/ZON per kg diet.
authors: Unit of Reproductive Biology, FBN Research Institute for the Biology of Farm Animals, 18196 Dummerstorf, Germany. tiemann@fbn-dummerstorf.de
authors: U
authors: U
authors: Tiemann
authors: K-P
authors: KP
authors: Brüssow
authors: U
authors: U
authors: Küchenmeister
authors: L
authors: L
authors: Jonas
authors: R
authors: R
authors: Pöhland
authors: A
authors: A
authors: Reischauer
authors: K
authors: K
authors: Jäger
authors: S
authors: S
authors: Dänicke
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D017301:Ca(2+) Mg(2+)-ATPase / Q000378:metabolism; D048708:Cell Growth Processes / Q000187:drug effects; D005260:Female; D047109:Fetal Development / Q000187:drug effects; D006651:Histocytochemistry / Q000662:veterinary; D007136:Immunoglobulins / Q000097:blood; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism / Q000648:ultrastructure; D008854:Microscopy, Electron / Q000662:veterinary; D009183:Mycotoxins / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000633:toxicity*; D011247:Pregnancy; D013154:Spleen / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D013552:Swine / Q000378:metabolism*; D014255:Trichothecenes / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000633:toxicity*; D015025:Zearalenone / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000633:toxicity*
chemical_list: D007136:Immunoglobulins; D009183:Mycotoxins; D014255:Trichothecenes; D015025:Zearalenone; D017301:Ca(2+) Mg(2+)-ATPase; C007262:deoxynivalenol