[New biological active derivatives of indomethacin and acetylsalicylic acid. Synthesis, physico-chemical characterisation and structure validation].
It is well known that niflumic acid glycinamide has a good antiinflammatory action useful in gum inflammatory diseases. The objective of this study was to obtain new glycinamides of acetylsalicylic acid and indomethacin, which could have a better antiinflammatory action than niflumic acid glycinamide. The study presents the synthesis, physico-chemical characterisation and structure validation of these glycinamides.
Stan
Catalina
C
Facultatea de Farmacie, Universitatea de Medicina şi Farmacie "Gr. T. Popa", Iaşi.
Stefanache
Alina
A
Dumitrache
M
M
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis / Q000737:chemistry*; D001241:Aspirin / Q000737:chemistry*; D005998:Glycine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D006801:Humans; D007213:Indomethacin / Q000737:chemistry*; D007249:Inflammation / Q000188:drug therapy
D000894:Anti-Inflammatory Agents, Non-Steroidal; C018556:glycine amide; D001241:Aspirin; D005998:Glycine; D007213:Indomethacin