Subtyping method for Escherichia coli shiga toxin (verocytotoxin) 2 variants and correlations to clinical manifestations.
Shiga toxin 2 (Stx2) from Shiga toxin-producing Escherichia coli (STEC) was subtyped by a method involving partial sequencing of the stxAB2 operon. Of 255 strains from the Danish STEC cohort, all 20 cases of hemolytic-uremic syndrome were associated with subtype Stx2 (11 cases), subtype Stx2c (1 case), or the two combined (8 cases).
Persson
Søren
S
Department of Bacteriology, Mycology and Parasitology, The National Reference Laboratory for Enteropathogenic Bacteria, Unit of Gastrointestinal Infections, Statens Serum Institut, Artillerivej 5, Building 37B, 2300 Copenhagen S, Denmark. SPN@ssi.dk
Olsen
Katharina E P
KE
Ethelberg
Steen
S
Scheutz
Flemming
F
D000595:Amino Acid Sequence; D002648:Child; D003718:Denmark; D003967:Diarrhea / Q000382:microbiology / Q000503:physiopathology*; D004926:Escherichia coli / Q000145:classification* / Q000235:genetics / Q000472:pathogenicity*; D004927:Escherichia coli Infections / Q000382:microbiology / Q000503:physiopathology; D014644:Genetic Variation; D006463:Hemolytic-Uremic Syndrome / Q000382:microbiology / Q000503:physiopathology*; D006801:Humans; D008969:Molecular Sequence Data; D009876:Operon; D010802:Phylogeny; D017422:Sequence Analysis, DNA; D022641:Shiga Toxin 2 / Q000737:chemistry / Q000145:classification* / Q000235:genetics / Q000378:metabolism
D022641:Shiga Toxin 2