title: Mouse molar dentin size/shape is dependent on growth hormone status.
abstract: Growth hormone (GH) status affects dental development, but how GH influences tooth size/shape is unclear. Since GH affects dental epithelial proliferation, we hypothesized that GH influences the tooth crown and root dimensions. Dentin matrix dimensions were measured in longitudinal sections of decalcified first mandibular molars from 3 genetically modified mice: giant (GH-Excess) mice and dwarf (GH-Antagonist and GH-Receptor-Knockout) mice. GH status was found to influence crown width, root length, and dentin thickness. Analysis of these data suggests that GH influences both tooth crown and root development prior to dentinogenesis as well as during appositional growth of dentin. This is concordant with the expression of paracrine GH and GH receptors during tooth bud morphogenesis, and of GH receptors in the enamel organ, dental papilla, and Hertwig's epithelial root sheath during dentinogenesis. Based on prior studies, these GH morphogenetic actions may be mediated by the induction of both bone morphogenetic protein and insulin-like growth factor-1 expression.
authors: Oral Biology and Pathology, School of Dentistry, University of Queensland, St. Lucia, Queensland 4072, Australia. j.smid@uq.edu.au
authors: J R
authors: JR
authors: Smid
authors: J E
authors: JE
authors: Rowland
authors: W G
authors: WG
authors: Young
authors: K T
authors: KT
authors: Coschigano
authors: J J
authors: JJ
authors: Kopchick
authors: M J
authors: MJ
authors: Waters
mesh_terms: D000818:Animals; D003804:Dentin / Q000033:anatomy & histology*; D003810:Dentinogenesis / Q000502:physiology; D005260:Female; D013006:Growth Hormone / Q000494:pharmacology / Q000502:physiology*; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D008822:Mice, Transgenic; D008963:Molar / Q000033:anatomy & histology; D009805:Odontogenesis / Q000502:physiology*; D011994:Recombinant Proteins / Q000494:pharmacology; D019228:Tooth Crown / Q000033:anatomy & histology; D014092:Tooth Root / Q000033:anatomy & histology
chemical_list: D011994:Recombinant Proteins; D013006:Growth Hormone