Prevention of alveolar osteitis with azithromycin in women according to use of tobacco and oral contraceptives.
OBJECTIVE
To evaluate the efficacy and tolerance of azithromycin in the prevention of post-extraction alveolar osteitis (dry socket) in women according to their use of tobacco and oral contraceptives.


METHODS
A clinical trial was conducted in 400 women who underwent tooth extraction, stratified into 4 risk groups according to their use of tobacco (yes/no) and oral contraceptives (yes/no). Each stratum (n = 100) was randomly divided into 2 groups: a study group that received azithromycin 500 mg once daily for 3 days after extraction and a control group that received physiologic saline 3 times daily from 24 hours after extraction for 7 days.


RESULTS
Azithromycin was significantly superior to conventional postextraction treatment with physiologic saline. There were no significant interactions with the use of either tobacco or oral contraceptives, and these variables had no confounding effects.


CONCLUSIONS
Azithromycin is a safe and efficacious treatment for the prevention of dry socket in women.
Bascones-Martinez
Antonio
A
Oral Medicine and Periodontology, School of Dentistry, Compultense University, Madrid, Spain. antbasco@odon.ucm.es
Reche
Isabel
I
Manso
Francisco
F
González-Moles
Miguel Angel
MA
Bravo
Manuel
M
D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D017963:Azithromycin / Q000627:therapeutic use*; D003276:Contraceptives, Oral / Q000009:adverse effects; D004368:Dry Socket / Q000209:etiology / Q000517:prevention & control*; D015987:Effect Modifier, Epidemiologic; D005260:Female; D006801:Humans; D016015:Logistic Models; D011446:Prospective Studies; D016037:Single-Blind Method; D012907:Smoking / Q000009:adverse effects; D014081:Tooth Extraction / Q000009:adverse effects
D000900:Anti-Bacterial Agents; D003276:Contraceptives, Oral; D017963:Azithromycin