Interaction of erythrocytes with magnetic nanoparticles.
Internalization of biocompatible magnetic nanoparticles by red blood cells (RBCs) is a key issue for opportunities of new applications in the biomedical field. In this study, we used in vitro tests to provide evidences of magnetic nanoparticle internalization by mice red blood cells. The internalization process depends upon the nanoparticle concentration and the nanoparticle hydrodynamic radii. The cell internalization of surface-coated maghemite nanoparticles was indirectly tracked by Raman spectroscopy and directly observed using transmission electron microscopy. The observation of nanoparticle cell uptaking using in vitro experiments represents an important breakthrough for the application of nanomagnetism in diagnosis and therapy of RBC-related diseases.
Soler
Maria A G
MA
Instituto de Fisica, Universidade de Brasilia, Brasilia-DF 70910-900, Brazil.
Báo
Sônia N
SN
Alcântara
Gustavo B
GB
Tibúrcio
Victor H S
VH
Paludo
Giane R
GR
Santana
José F B
JF
Guedes
Maria H
MH
Lima
Emilia C D
EC
Lacava
Zulmira G M
ZG
Morais
Paulo C
PC
D000818:Animals; D001693:Biological Transport, Active; D020099:Coated Materials, Biocompatible / Q000737:chemistry; D004912:Erythrocytes / Q000378:metabolism* / Q000648:ultrastructure; D066298:In Vitro Techniques; D008280:Magnetics; D008422:Materials Testing; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D051379:Mice; D008854:Microscopy, Electron; D036103:Nanotechnology; D013059:Spectrum Analysis, Raman
D020099:Coated Materials, Biocompatible