title: Nitric oxide-independent cGMP efflux in the striatum of rats exposed to carbon monoxide as determined by microdialysis.
abstract: Extracellular cGMP in the striatum of rats exposed to 3000 ppm carbon monoxide (CO) or 8% O2 was decreased during the early period of exposure. Thereafter, extracellular cGMP in rats exposed to CO, but not 8% O2, was transiently increased. A nitric oxide (NO) synthase inhibitor, NG-nitro-L-arginine, strongly reduced the steady-state level of extracellular cGMP in the striatum, indicating a primary role of NO in cGMP production. However, it failed to suppress the CO-induced increase in extracellular cGMP in the striatum. These findings suggest that CO may stimulate cGMP production in rat striatum independently of NO and hypoxia.
authors: Department of Forensic Medicine, Tokyo Medical University, Japan. s-hara@tokyo-med.ac.jp
authors: Shuichi
authors: S
authors: Hara
authors: Toshiji
authors: T
authors: Mukai
authors: Hajime
authors: H
authors: Mizukami
authors: Fumi
authors: F
authors: Kuriiwa
authors: Takashi
authors: T
authors: Watanabe
authors: Takahiko
authors: T
authors: Endo
mesh_terms: D000818:Animals; D002248:Carbon Monoxide / Q000494:pharmacology*; D003342:Corpus Striatum / Q000187:drug effects* / Q000378:metabolism; D006152:Cyclic GMP / Q000378:metabolism*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D045604:Extracellular Fluid / Q000187:drug effects / Q000378:metabolism; D008297:Male; D017551:Microdialysis / Q000379:methods*; D019335:Nitroarginine / Q000494:pharmacology; D010100:Oxygen / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
chemical_list: D004791:Enzyme Inhibitors; D019335:Nitroarginine; D002248:Carbon Monoxide; D006152:Cyclic GMP; D010100:Oxygen