Nanoporous hard carbon membranes for medical applications.
Current blood glucose sensors have proven to be inadequate for long term in vivo applications; membrane biofouling and inflammation play significant roles in sensor instability. An ideal biosensor membrane material must prevent protein adsorption and promote integration of the sensor with the surrounding tissue. Furthermore, biosensor membranes must be sufficiently thin and porous in order to allow the sensor to rapidly respond to fluctuations in analyte concentration. In this study, the use of diamondlike carbon-coated anodized aluminum oxide as a potential biosensor membrane is discussed. Diamondlike carbon films and diamondlike carbon-coated anodized aluminum oxide nanoporous membranes were examined using scanning electron microscopy, atomic force microscopy, X-ray photoelectron spectroscopy, Raman spectroscopy, and platelet rich plasma testing. The diamondlike carbon-coated anodized aluminum oxide membranes remained free from protein adsorption during in vitro platelet rich plasma testing. We anticipate that this novel membrane could find use in immunoisolation devices, pacemakers, kidney dialysis membranes, microdialysis systems, and other devices facing biocompatibility issues that limit in vivo function.
Narayan
Roger J
RJ
Department of Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Jin
Chunming
C
Menegazzo
Nicola
N
Mizaikoff
Boris
B
Gerhardt
Rosario A
RA
Andara
Melanie
M
Agarwal
Arvind
A
Shih
Chun-Che
CC
Shih
Chun-Ming
CM
Lin
Shing-Jong
SJ
Su
Yea-Yang
YY
D000327:Adsorption; D000537:Aluminum Oxide / Q000737:chemistry; D001672:Biocompatible Materials / Q000737:chemistry*; D015374:Biosensing Techniques; D002244:Carbon / Q000737:chemistry*; D004563:Electrochemistry / Q000379:methods; D004867:Equipment Design; D008422:Materials Testing; D008566:Membranes / Q000737:chemistry; D008855:Microscopy, Electron, Scanning; D036103:Nanotechnology / Q000379:methods*; D037742:Nanotubes, Carbon / Q000737:chemistry*; D013059:Spectrum Analysis, Raman
D001672:Biocompatible Materials; D037742:Nanotubes, Carbon; D002244:Carbon; D000537:Aluminum Oxide