title: Lentiviral nuclear import: a complex interplay between virus and host.
abstract: Although the capacity to infect non-dividing cells is a hallmark of lentiviruses, nuclear import is still barely understood. More than 100 research papers have been dedicated to this topic during the last 15 years, yet, more questions have been raised than answers. The signal-facilitating translocation of the viral preintegration complex (PIC) through the nuclear pore complex (NPC) remains unknown. It is clear, however, that nuclear import is the result of a complex interplay between viral and cellular components. In this review, we discuss the current knowledge on nuclear import. We focus on the controversies and pitfalls and discuss the interplay between virus and host.
authors: Laboratory for Molecular Virology and Gene Therapy, KULeuven and IRC KULAK, Leuven, Belgium.
authors: Jan
authors: J
authors: De Rijck
authors: Linos
authors: L
authors: Vandekerckhove
authors: Frauke
authors: F
authors: Christ
authors: Zeger
authors: Z
authors: Debyser
mesh_terms: D021581:Active Transport, Cell Nucleus; D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism* / Q000821:virology*; D004279:DNA, Viral / Q000235:genetics; D006801:Humans; D016086:Lentivirus / Q000502:physiology*; D011991:Receptors, Virus / Q000378:metabolism; D014779:Virus Replication
chemical_list: D004279:DNA, Viral; D011991:Receptors, Virus