title: Naphthyl piperazines with dual activity as 5-HT1D antagonists and 5-HT reuptake inhibitors.
abstract: SAR around a known molecule with dual 5-HT(1D) antagonist and 5-HT(transporter) inhibitory activity has led to the discovery of molecules with improved dual activity and reduced cross-reactivity toward other aminergic receptors (5-HT(1B), alpha(1), and D(2)).
authors: Lilly SA, Avda. de la Industria, 30, 28108, Alcobendas, Madrid, Spain. bueno_ana_belen@lilly.com
authors: Ana B
authors: AB
authors: Bueno
authors: Jeremy
authors: J
authors: Gilmore
authors: John
authors: J
authors: Boot
authors: Richard
authors: R
authors: Broadmore
authors: Jane
authors: J
authors: Cooper
authors: Jeremy
authors: J
authors: Findlay
authors: Lorna
authors: L
authors: Hayhurst
authors: Alicia
authors: A
authors: Marcos
authors: Carlos
authors: C
authors: Montero
authors: Stephen
authors: S
authors: Mitchell
authors: Graham
authors: G
authors: Timms
authors: Rosemarie
authors: R
authors: Tomlinson
authors: Louise
authors: L
authors: Wallace
authors: Leslie
authors: L
authors: Walton
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D007700:Kinetics; D008956:Models, Chemical; D009281:Naphthalenes / Q000737:chemistry*; D010879:Piperazines / Q000138:chemical synthesis / Q000494:pharmacology*; D044346:Receptor, Serotonin, 5-HT1D / Q000187:drug effects* / Q000378:metabolism; D012702:Serotonin Antagonists / Q000138:chemical synthesis / Q000494:pharmacology*; D017367:Selective Serotonin Reuptake Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D000928:Antidepressive Agents; D009281:Naphthalenes; D010879:Piperazines; D044346:Receptor, Serotonin, 5-HT1D; D012702:Serotonin Antagonists; D017367:Selective Serotonin Reuptake Inhibitors