New developments in FcepsilonRI regulation, function and inhibition.
The high-affinity Fc receptor for IgE (FcepsilonRI), a multimeric immune receptor, is a crucial structure for IgE-mediated allergic reactions. In recent years, advances have been made in several important areas of the study of FcepsilonRI. The first area relates to FcepsilonRI-mediated biological responses that are antigen independent. The second area encompasses the biological relevance of the distinct signalling pathways that are activated by FcepsilonRI; and the third area relates to the accumulated evidence for the tight control of FcepsilonRI signalling through a broad array of inhibitory mechanisms, which are being developed into promising therapeutic approaches.
Kraft
Stefan
S
Laboratory of Allergy and Immunology, Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine 945, 71 Avenue Louis Pasteur, Boston, Massachusetts 02215, USA.
Kinet
Jean-Pierre
JP
D000818:Animals; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology*; D018448:Models, Immunological; D017455:Receptors, IgE; D015398:Signal Transduction / Q000276:immunology*
C502447:MS4A2 protein, human; D017455:Receptors, IgE