title: Highway to the inner nuclear membrane: rules for the road.
abstract: To enter the nucleus a protein must be chaperoned by a transport factor through the nuclear pore complex or it must be small enough to pass through by diffusion. Although these principles have long described the nuclear import of soluble proteins, recent evidence indicates that they also apply to the import of integral inner nuclear membrane proteins. Here we develop a set of rules that might govern the transport of proteins to the inner nuclear membrane.
authors: Laboratory of Cell Biology, Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.
authors: C Patrick
authors: CP
authors: Lusk
authors: Günter
authors: G
authors: Blobel
authors: Megan C
authors: MC
authors: King
mesh_terms: D021581:Active Transport, Cell Nucleus / Q000502:physiology*; D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism*; D006801:Humans; D028884:Karyopherins / Q000502:physiology; D008954:Models, Biological; D009685:Nuclear Envelope / Q000502:physiology*; D019913:Nuclear Localization Signals / Q000502:physiology; D022022:Nuclear Pore / Q000502:physiology; D028861:Nuclear Pore Complex Proteins / Q000502:physiology; D021381:Protein Transport / Q000502:physiology
chemical_list: D028884:Karyopherins; D019913:Nuclear Localization Signals; D028861:Nuclear Pore Complex Proteins