title: Urodynamic changes in a noble rat model for nonbacterial prostatic inflammation.
abstract: BACKGROUND
  Chronic nonbacterial prostatitis (CP) associated with voiding dysfunction is a poorly understood clinical phenomenon. The goal of the present study was to induce prostatic inflammation with estrogen and androgen treatment and to record associated urodynamic changes in Noble rats.
  
  
  METHODS
  Rats were treated with estradiol and testosterone implants to increase estradiol concentration in serum while testosterone concentration was maintained at or slightly above the control level. The urodynamical recordings were performed under anesthesia after the hormone treatments for 3 and 6 weeks. The dorsolateral lobes of the prostates were removed for histopathological analysis after recordings.
  
  
  RESULTS
  After the 3-week treatment, lymphocytes, mainly T-cells, were located around the capillaries. During the following 3 weeks lymphocytes migrated into stroma and acini. Cytotoxic T-cells were seen intraepithelially, and neutrophiles inside the acini. Removal of estrogen implant or treatment with anti-estrogen diminished inflammation. No changes in voiding pattern were seen after the 3-week treatment. Three weeks later, bladder weight and capacity were increased, and the micturition time was prolonged.
  
  
  CONCLUSIONS
  Elevated estrogen concentration was essential for the gradual development of prostatic inflammation. The profile and location of inflammatory cells suggest that prostatic vasculature is one of the sites of estrogen action. Urodynamic changes which developed in association with glandular inflammation indicated abnormal bladder function, reflecting an incipient obstruction.
authors: Institute of Biomedicine, Department of Anatomy, University of Turku, Turku, Finland. jenni.bernoulli@utu.fi
authors: Jenni
authors: J
authors: Bernoulli
authors: Emrah
authors: E
authors: Yatkin
authors: Eva-Maria
authors: EM
authors: Talvitie
authors: Risto
authors: R
authors: Santti
authors: Tomi
authors: T
authors: Streng
mesh_terms: D000818:Animals; D004576:Electromyography; D004958:Estradiol / Q000031:analogs & derivatives / Q000494:pharmacology*; D004965:Estrogen Antagonists / Q000494:pharmacology; D000077267:Fulvestrant; D006651:Histocytochemistry; D008297:Male; D009929:Organ Size; D011472:Prostatitis / Q000139:chemically induced / Q000503:physiopathology*; D051381:Rats; D018709:Statistics, Nonparametric; D013739:Testosterone / Q000494:pharmacology*; D001743:Urinary Bladder / Q000187:drug effects / Q000503:physiopathology*; D014555:Urination Disorders / Q000139:chemically induced / Q000503:physiopathology*
chemical_list: D004965:Estrogen Antagonists; D000077267:Fulvestrant; D013739:Testosterone; D004958:Estradiol