title: Inflammatory myofibroblastic tumor of paranasal sinuses.
abstract: Inflammatory myofibroblastic tumors IMTs are clinico-pathologically distinctive but biologically controversial entities; they rarely affect the head and neck region and usually follow a benign clinical course after radical excision. We reviewed the literatures of IMTs and present a rare case of IMT arising from the maxillary paranasal sinus of an 11-year-old girl. Moreover, we elaborate on the morpho-immunophenotypic characteristics of this lesion. Microscopic examination revealed a spindle cell proliferation set in a highly vascular stroma with numerous inflammatory cells. Tumor cells were immunoreactive for vimentin, and smooth muscle actin, negative for desmin, S-100, p53, Cyclin D1, and bcl-2. The potential neoplastic nature of this lesion was substantiated by the strong diffuse immuno-expression of ALK-1 protein, a marker that has been linked to neoplastic transformation. The lesion was excised completely by a CO2 LASER as a new treatment modality and the patient manifested no evidence of disease recurrence at 10-months recall.
authors: Department of Pathology, Bahrain Defence Force Hospital, PO Box 28743, Kingdom of Bahrain. khalid.alsindi@bdfmedical.org
authors: Khalid
authors: K
authors: Al-Sindi
authors: Mohamed H
authors: MH
authors: Al-Shehabi
authors: Salman A
authors: SA
authors: Al-Khalifa
mesh_terms: D002648:Child; D004844:Epistaxis; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007249:Inflammation / Q000276:immunology; D053685:Laser Therapy; D009379:Neoplasms, Muscle Tissue / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D010255:Paranasal Sinus Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D011859:Radiography