title: GENOME: a rapid coalescent-based whole genome simulator.
abstract: CONCLUSIONS
  GENOME proposes a rapid coalescent-based approach to simulate whole genome data. In addition to features of standard coalescent simulators, the program allows for recombination rates to vary along the genome and for flexible population histories. Within small regions, we have evaluated samples simulated by GENOME to verify that GENOME provides the expected LD patterns and frequency spectra. The program can be used to study the sampling properties of any statistic for a whole genome study.
  
  
  BACKGROUND
  The program and C++ source code are available online at http://www.sph.umich.edu/csg/liang/genome/
authors: Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA. lianglim@umich.edu
authors: Liming
authors: L
authors: Liang
authors: Sebastian
authors: S
authors: Zöllner
authors: Gonçalo R
authors: GR
authors: Abecasis
mesh_terms: D000483:Alleles; D019295:Computational Biology / Q000379:methods*; D003198:Computer Simulation; D005787:Gene Frequency; D016678:Genome; D015894:Genome, Human; D006801:Humans; D008957:Models, Genetic; D009154:Mutation; D011381:Programming Languages; D011995:Recombination, Genetic; D017422:Sequence Analysis, DNA; D012984:Software