G-protein-coupled receptor expression, function, and signaling in macrophages.
G-protein-coupled receptors (GPCRs) are widely targeted in drug discovery. As macrophages are key cellular mediators of acute and chronic inflammation, we review here the role of GPCRs in regulating macrophage function, with a focus on contribution to disease pathology and potential therapeutic applications. Within this analysis, we highlight novel GPCRs with a macrophage-restricted expression profile, which provide avenues for further exploration. We also review an emerging literature, which documents novel roles for GPCR signaling components in GPCR-independent signaling in macrophages. In particular, we examine the crosstalk between GPCR and TLR signaling pathways and highlight GPCR signaling molecules which are likely to have uncharacterized functions in this cell lineage.
Lattin
Jane
J
Cooperative Research Centre for Chronic Inflammatory Diseases, University of Queensland, St. Lucia, Brisbane, QLD 4072, Australia.
Zidar
David A
DA
Schroder
Kate
K
Kellie
Stuart
S
Hume
David A
DA
Sweet
Matthew J
MJ
D000818:Animals; D006801:Humans; D008264:Macrophages / Q000737:chemistry / Q000502:physiology; D020239:Receptor Cross-Talk; D043562:Receptors, G-Protein-Coupled / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D015398:Signal Transduction; D051193:Toll-Like Receptors / Q000378:metabolism / Q000502:physiology
D043562:Receptors, G-Protein-Coupled; D051193:Toll-Like Receptors