[Automatic auditory information management in panic disorder patients: an event-related potentials study].
OBJECTIVE
To investigate the characteristics of automatic auditory information management in sufferers of panic disorder (PD).


METHODS
Mismatch negativity (MMN), as a component of event-related potentials, was recorded from 15 PD patients, 8 males and 7 females, aged 40 +/- 12, and 15 sex, and aged-matched controls. Repeated measures ANOVA was used on 4 representative electrodes: T3, T4, F3, and F4.


RESULTS
Compared with the normal controls, the PD patients showed significant enlargement of MMN amplitude in 60 - 210 ms latency windows (60 - 110 ms: F(1, 28) = 11.413, P = 0.02; 110 - 160 ms: F(1, 28) = 6.639, P = 0.016; 160 - 210 ms: F(1, 28) = 5.758, P = 0.023), and exhibited early (60 - 160 ms) left encephalic region predominant effect.


CONCLUSIONS
PD patients may deal excessive automatic processing of the auditory information changes which may assist in offering new objective evidence to understand the etiology of PD.
Li
Qing-dong
QD
Department of Neurology, First Affiliated Hospital of Dalian Medical University, Dalian 116011, China.
Xu
Jing
J
Zhao
Lun
L
Liu
Xiao-wei
XW
Zhang
Bing-wei
BW
D000328:Adult; D000704:Analysis of Variance; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016584:Panic Disorder / Q000503:physiopathology* / Q000523:psychology