Cellular stress and intracellular zinc dyshomeostasis.
Various stressful conditions like oxidative or nitrosative stress, heavy metal load or thiol-modifying compounds have been shown to disturb the intracellular zinc homeostasis leading to increasing concentrations of free zinc within the cytoplasm or nuclei of cells. However, much less is known about the consequences of a disturbed intracellular Zn2+ homeostasis under these conditions. Current knowledge is reviewed here.
Kröncke
Klaus-D
KD
Institute of Biochemistry and Molecular Biology I, Heinrich-Heine-University of Düsseldorf, Universitätsstr.1, D-40225, Düsseldorf, Germany. kroencke@uni-duesseldorf.de
D000818:Animals; D006706:Homeostasis; D006801:Humans; D019216:Metals, Heavy / Q000633:toxicity; D051379:Mice; D009569:Nitric Oxide / Q000378:metabolism; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000378:metabolism; D015032:Zinc / Q000378:metabolism*
D019216:Metals, Heavy; D017382:Reactive Oxygen Species; D009569:Nitric Oxide; D015032:Zinc