Hodgkin's lymphoma initially presenting with polymyalgic symptoms: a case report.
The association of polymyalgic symptoms and lymphoma is a rare event whose pathogenesis remains to be clarified. Here, we describe a case of a 75-year old man with Hodgkin's lymphoma, who had presented with polymyalgic symptoms suggesting polymyalgia rheumatica. An intensive investigation with respect to malignancy was initially negative. Corticosteroid treatment was administered first and a dramatic clinical improvement was achieved. Four months later, when the corticosteroid treatment was tapered off, the initial manifestations reappeared. After the development of lymph node enlargement, the patient was diagnosed by lymph node biopsy as having Hodgkin's lymphoma. The lymphadenopathy and musculoskeletal manifestations all responded well to chemotherapy. Hodgkin's lymphoma should be considered in the differential diagnosis of PMR. These musculoskeletal syndromes should alert the physician to possible paraneoplastic manifestations of an evolving neoplasm.
Sahin
Mehmet
M
Division of Rheumatology, Department of Internal Medicine, Suleyman Demirel University School of Medicine, TR-32260 Isparta, Turkey. mehmetsahin66@hotmail.com
Alanoglu
Guchan
G
Aksu
Oguzhan
O
Tunc
Sevket Ercan
SE
Kapucuoglu
Nilgun
N
Yener
Mahmut
M
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D006099:Granuloma / Q000209:etiology; D006689:Hodgkin Disease / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D008297:Male; D009367:Neoplasm Staging; D011111:Polymyalgia Rheumatica / Q000209:etiology*; D016896:Treatment Outcome