title: Sutureless vascular anastomoses by N-butyl-2 cyanoacrylate adhesive: an experimental animal study.
abstract: BACKGROUND
  The purpose of this animal study was to find out whether sutureless anastomoses using N-butyl-2-cyanoacrylate were effective in the suppression of neointimal hyperplasia or not.
  
  
  METHODS
  Ten male adult mongrel dogs were used in this animal study. The animals were randomly divided into a control group (n = 5) and a study group (n = 5). The study group underwent sutureless anastomoses using N-buthyl-2-cyanoacrylate adhesive. Infrarenal aortoaortic graft was interposed using polytetrafluoroethylene.
  
  
  RESULTS
  In the study group, the mean intimal thickness at the proximal anastomosis was 27.4 +/- 1.94 microm and 27.4 +/- 1.51 microm at the distal anastomosis. In the control group, the mean intimal thickness was 138.4 +/- 5.02 mum at the proximal anastomosis and 67.6 +/- 6.42 microm at the distal anastomosis. Intimal thickness at the proximal and distal anastomoses in the control group was significantly (p < 0.001) greater than in the study group. Also, perianastomotic inflammation was more obvious in the control group compared to the study group (p < 0.01).
  
  
  CONCLUSIONS
  Sutureless anastomoses using with N-butyl-2-cyanoacrylate adhesive might be a good alternative to conventional suture technique.
authors: Department of Cardiovascular Surgery, Faculty of Medicine, Uludag University, Bursa, Turkey. davids@uludag.edu.tr
authors: D
authors: D
authors: Saba
authors: M
authors: M
authors: Yilmaz
authors: H
authors: H
authors: Yavuz
authors: S
authors: S
authors: Noyan
authors: B
authors: B
authors: Avci
authors: A
authors: A
authors: Ercan
authors: H
authors: H
authors: Ozkan
authors: M
authors: M
authors: Cengiz
mesh_terms: D000714:Anastomosis, Surgical / Q000379:methods*; D000818:Animals; D001011:Aorta / Q000473:pathology / Q000601:surgery*; D004285:Dogs; D004659:Enbucrilate / Q000031:analogs & derivatives* / Q000494:pharmacology; D006965:Hyperplasia; D008297:Male; D023421:Models, Animal; D013537:Sutures; D014014:Tissue Adhesives / Q000494:pharmacology*; D017539:Tunica Intima / Q000473:pathology; D014656:Vascular Surgical Procedures / Q000379:methods*
chemical_list: D014014:Tissue Adhesives; D004659:Enbucrilate