Sulfonylurea-responsive diabetes in childhood.
We describe a family in which 3/6 siblings had transient, relapsing neonatal diabetes. The father and another sibling had diabetes diagnosed at 20 and 9 years old, respectively. All affected individuals carried the same KCNJ11 gene mutation. In all, sulfonylurea treatment permitted cessation of insulin treatment, with improved glycemic control.
Landau
Zohar
Z
Diabetes Unit, E. Wolfson Medical Center, Holon, Israel.
Wainstein
Julio
J
Hanukoglu
Aaron
A
Tuval
Myriam
M
Lavie
Judith
J
Glaser
Benjamin
B
D000328:Adult; D002648:Child; D003920:Diabetes Mellitus / Q000188:drug therapy* / Q000235:genetics; D005260:Female; D005905:Glyburide / Q000627:therapeutic use*; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007231:Infant, Newborn; D008297:Male; D009154:Mutation; D010375:Pedigree; D024661:Potassium Channels, Inwardly Rectifying / Q000235:genetics; D013453:Sulfonylurea Compounds / Q000627:therapeutic use; D000099161:Kcnj11 Channel
D005905:Glyburide; D007004:Hypoglycemic Agents; D024661:Potassium Channels, Inwardly Rectifying; D013453:Sulfonylurea Compounds; D000099161:Kcnj11 Channel