Genetic and molecular mechanisms of chemical atherogenesis.
Injury to the cellular components of the vascular wall and blood by endogenous and exogenous chemicals has been associated with atherosclerosis in humans and experimental systems. The genetic and molecular mechanisms responsible for initiation and promotion of atherosclerotic changes include modulation of extracellular matrix-integrin axis, genes involved in the regulation of growth and differentiation and possibly, genomic stability. This review summarizes seminal studies over the past 20 years that shed light on critical gene-gene and gene-environment interactions mediating the atherogenic response to chemical injury.
Ramos
Kenneth S
KS
Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, Louisville, KY 40292, United States. kenneth.ramos@louisville.edu
Partridge
Charles R
CR
Teneng
Ivo
I
D000818:Animals; D050197:Atherosclerosis / Q000139:chemically induced / Q000235:genetics / Q000378:metabolism; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D018384:Oxidative Stress / Q000187:drug effects / Q000235:genetics; D017382:Reactive Oxygen Species / Q000378:metabolism
D017382:Reactive Oxygen Species