Part VII. Macrolides, azalides, ketolides, lincosamides, and streptogramins.
In this article we describe antimicrobials that are grouped by their similar mechanism of action, namely inhibition of protein synthesis at the bacterial 50S ribosomal subunit. Macrolides, azalides, and ketolides are primarily used to treat community acquired respiratory tract infections. A lincosamide antibiotic, clindamycin, is primarily used to treat anaerobic infections. A combination of streptogramins, quinupristin/dalfopristin, is used to treat infections due to multiple drug resistant Gram positive cocci.
Dang
Van
V
Infectious Diseases Section, PO Box 26901, WP 1160. Oklahoma City, OK 73190, USA.
Nanda
Neha
N
Cooper
Travis W
TW
Greenfield
Ronald A
RA
Bronze
Michael S
MS
D001424:Bacterial Infections / Q000188:drug therapy; D006801:Humans; D018942:Macrolides / Q000494:pharmacology* / Q000627:therapeutic use; D025361:Streptogramins / Q000494:pharmacology* / Q000627:therapeutic use
D018942:Macrolides; D025361:Streptogramins