Phyllodes tumors of the breast: natural history, diagnosis, and treatment.
Phyllodes tumors of the breast are unusual fibroepithelial tumors that exhibit a wide range of clinical behavior. These tumors are categorized as benign, borderline, or malignant based on a combination of histologic features. The prognosis of phyllodes tumors is favorable, with local recurrence occurring in approximately 15% of patients overall and distant recurrence in approximately 5% to 10% overall. Wide excision with a greater than 1 cm margin is definitive primary therapy. Adjuvant systemic therapy is of no proven value. Patients with locally recurrent disease should undergo wide excision of the recurrence with or without subsequent radiotherapy.
Telli
Melinda L
ML
Department of Medicine, Stanford University, Stanford, CA, USA.
Horst
Kathleen C
KC
Guardino
Alice E
AE
Dirbas
Frederick M
FM
Carlson
Robert W
RW
D001943:Breast Neoplasms / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D005260:Female; D006801:Humans; D003557:Phyllodes Tumor / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D011379:Prognosis