title: The utility of nutraceuticals in the treatment of osteoarthritis.
abstract: Osteoarthritis (OA) treatment is limited by the inability of prescribed medications to alter disease outcome. As a result, patients with OA often take food substances called nutraceuticals in an attempt to affect the structural changes that occur within a degenerating joint. The role of nutraceuticals in OA management can be defined only by an evidence-based approach to support their use. This paper reviews the clinical trials studying glucosamine, chondroitin sulfate, vitamin C, vitamin E, and avocado-soybean unsaponifiables. It highlights the need for additional randomized, placebo-controlled trials to further define the utility of nutraceuticals in OA treatment.
authors: Division of Rheumatology, University of Utah School of Medicine, George E. Wahlen Veterans Affairs Medical Center, 4B200 School of Medicine, 50 North Medical Drive, Salt Lake, UT 84132, USA.
authors: Tracy M
authors: TM
authors: Frech
authors: Daniel O
authors: DO
authors: Clegg
mesh_terms: D001205:Ascorbic Acid / Q000627:therapeutic use; D002358:Cartilage, Articular / Q000187:drug effects* / Q000502:physiology; D002809:Chondroitin Sulfates / Q000627:therapeutic use; D019587:Dietary Supplements; D005944:Glucosamine / Q000627:therapeutic use; D006801:Humans; D010003:Osteoarthritis / Q000188:drug therapy*; D027421:Persea; D010936:Plant Extracts / Q000627:therapeutic use; D016032:Randomized Controlled Trials as Topic; D013025:Glycine max; D014810:Vitamin E / Q000627:therapeutic use
chemical_list: D010936:Plant Extracts; D014810:Vitamin E; D002809:Chondroitin Sulfates; D005944:Glucosamine; D001205:Ascorbic Acid