title: Non-apoptogenic Ca2+-related extrusion of mitochondria in anoxia/reoxygenation stress.
abstract: Tumor cells often develop molecular strategies for survival to anoxia/reoxygenation stress as part of tumor progression. Here we describe that the B lymphoma Epstein-Barr-positive cells E2r survive reoxygenation in spite of a very high and long-lasting increase in cytosolic Ca2+ and the loss of about half of their mitochondria due to specific extrusion of the organelles from the cells. The extrusion typically occurs 3 days after reoxygenation, and a regular mitochondrial asset is regained after further 24 h.
authors: Dipartimento di Biologia, Università di Roma Tor Vergata, via Ricerca Scientifica 1, 00133 Roma, Italy.
authors: Annalisa
authors: A
authors: Dorio
authors: Claudia
authors: C
authors: Cerella
authors: Milena
authors: M
authors: De Nicola
authors: Maria
authors: M
authors: D'Alessio
authors: Giampiero
authors: G
authors: Gualandi
authors: Lina
authors: L
authors: Ghibelli
mesh_terms: D017209:Apoptosis; D002118:Calcium / Q000378:metabolism*; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D006801:Humans; D008928:Mitochondria / Q000378:metabolism*; D010100:Oxygen / Q000378:metabolism*
chemical_list: D010100:Oxygen; D002118:Calcium