title: Patterning of frontal cortex subdivisions by Fgf17.
abstract: The frontal cortex (FC) is the seat of higher cognition. The genetic mechanisms that control formation of the functionally distinct subdivisions of the FC are unknown. Using a set of gene expression markers that distinguish subdivisions of the newborn mouse FC, we show that loss of Fgf17 selectively reduces the size of the dorsal FC whereas ventral/orbital FC appears normal. These changes are complemented by a rostral shift of sensory cortical areas. Thus, Fgf17 functions similar to Fgf8 in patterning the overall neocortical map but has a more selective role in regulating the properties of the dorsal but not ventral FC.
authors: Medical Scientist Training Program, University of California, San Francisco, CA 94143-2611, USA.
authors: Jeremy A
authors: JA
authors: Cholfin
authors: John L R
authors: JL
authors: Rubenstein
mesh_terms: D000818:Animals; D015415:Biomarkers; D019521:Body Patterning; D051524:Fibroblast Growth Factor 8 / Q000378:metabolism; D005346:Fibroblast Growth Factors / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*; D005625:Frontal Lobe / Q000196:embryology* / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D051379:Mice; D018345:Mice, Knockout; D009154:Mutation / Q000235:genetics
chemical_list: D015415:Biomarkers; C484726:Fgf17 protein, mouse; C496457:Fgf8 protein, mouse; D051524:Fibroblast Growth Factor 8; D005346:Fibroblast Growth Factors