[HIV-1 molecular epidemiological survey of drug users in Jiangxi province].
OBJECTIVE
To investigate HIV-1 molecular epidemiology of drug users in Jiangxi Province to analyze epidemic situation, subtype, origin of strain, and variation, and to provide information for prevention and control of AIDS.


METHODS
Combining principles of traditional epidemiology and molecular epidemiology, the authors analyzed the epidemiologically related factors, the gene sequences and systematic mutation of HIV-1 gene in nine drug users in Jiangxi province.


RESULTS
The HIV spread through the drug users in Jiangxi not only by injection but also by sexual contacts. The main epidemic strain found by sequence analysis was HIV-1 CRF01-AE that was closely related to the strain among drug users in Vietnam and Guangxi Zhuang Autonomous Region, with the average gene distance of 9.00 +/- 2.27 from the Vietnam strain. The origin of strain among drug users in the province was entirely the same.


CONCLUSIONS
At present, HIV-1 CRF01-AE strain has spread in the whole province among the drug users. Vigorous behavioral interventions should be developed in drug users and un-safe sexual behavior population to prevent the epidemic.
Yi
Zhi-qiang
ZQ
Jiangxi Center for Disease Control and Prevention, Nanchang 330029, China. Yi_zhiqi@yahoo.com.cn
Xing
Hui
H
Hu
Guo-liang
GL
Wei
Min
M
Zhou
Xiao-feng
XF
Liang
Hao
H
Jiang
Xiao-ming
XM
Lu
Fei-bao
FB
Chen
Hong
H
Shao
Yi-ming
YM
D000163:Acquired Immunodeficiency Syndrome / Q000453:epidemiology / Q000821:virology*; D000328:Adult; D002681:China / Q000453:epidemiology; D004279:DNA, Viral / Q000737:chemistry / Q000235:genetics; D004196:Disease Outbreaks / Q000517:prevention & control; D014644:Genetic Variation; D015497:HIV-1 / Q000145:classification / Q000235:genetics*; D006801:Humans; D008297:Male; D017720:Molecular Epidemiology; D017422:Sequence Analysis, DNA; D015819:Substance Abuse, Intravenous / Q000453:epidemiology / Q000821:virology*
D004279:DNA, Viral