Lung mechanics in the TIMP3 null mouse and its response to mechanical ventilation.
Tissue inhibitor of metalloproteinase-3 (TIMP3) null mice develop emphysema-like airspace enlargement due to an enzymatic imbalance. This study investigates how these abnormalities alter lung mechanics and the response to 2 different mechanical ventilation strategies. Phenotypically, TIMP3 null mice had increased compliance, and decreased resistance, tissue damping, and tissue elastance over wild-type controls. Decreased compliance and increased resistance were observed following the injurious ventilation strategy; however, the TIMP3 null response to both ventilation strategies was similar to wild-type mice. In conclusion, TIMP3 null mice have significant alterations in lung mechanics; however, this does not affect their response to ventilation.
Martin
Erica L
EL
Department of Physiology and Pharmacology, Lawson Health Research Institute, University of Western Ontario, London, Ontario, Canada.
Truscott
Emily A
EA
Bailey
Timothy C
TC
Leco
Kevin J
KJ
McCaig
Lynda A
LA
Lewis
James F
JF
Veldhuizen
Ruud A W
RA
D000403:Airway Resistance / Q000502:physiology; D000818:Animals; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry; D020868:Gene Silencing; D008170:Lung Compliance / Q000502:physiology; D008171:Lung Diseases / Q000201:enzymology* / Q000503:physiopathology*; D051379:Mice; D018345:Mice, Knockout; D037661:Pulmonary Surfactant-Associated Proteins / Q000032:analysis; D012121:Respiration, Artificial; D015656:Respiratory Mechanics; D019717:Tissue Inhibitor of Metalloproteinase-3 / Q000172:deficiency* / Q000235:genetics
D037661:Pulmonary Surfactant-Associated Proteins; D019717:Tissue Inhibitor of Metalloproteinase-3