title: Action of Schwann cells implanted in cerebral hemorrhage lesion.
abstract: OBJECTIVE
  To investigate whether there is neogenesis of myelin sheath and neuron after transplantation of Schwann cells into cerebral hemorrhage lesion.
  
  
  METHODS
  Schwann cells were expanded, labeled with BrdU in vitro and transplanted into rat cerebral hemorrhage with blood extracted from femoral artery and then injected into the basal nuclei. Double immunohistochemistry staining and electron microscopy were used to detect the expression of BrdU/MBP and BrdU/GAP-43 and remyelination.
  
  
  RESULTS
  BrdU/MBP double positive cells could be seen at 1 week up to 16 weeks after transplantation of Schwann cells. Thin remyelination was observed under electron microscope. GAP-43 positive cells appeared after 12 weeks and were found more in Hippocamp.
  
  
  CONCLUSIONS
  Grafted Schwann cells participate in remyelination and promoter nerve restore in rat cerebral hemorrhage.
authors: Beijing Neurosurgical Institute, Capital Medical University, Beijing, China. wanhong50@hotmail.com
authors: Hong
authors: H
authors: Wan
authors: Shao-Dong
authors: SD
authors: Zhang
authors: Jun-Hua
authors: JH
authors: Li
mesh_terms: D000818:Animals; D002543:Cerebral Hemorrhage / Q000378:metabolism / Q000628:therapy*; D019922:GAP-43 Protein / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012583:Schwann Cells / Q000378:metabolism / Q000637:transplantation*; D012584:Sciatic Nerve / Q000166:cytology / Q000196:embryology
chemical_list: D019922:GAP-43 Protein