Patterning skin pigmentation via dickkopf.
One of the striking regional variations in skin is its pigmentation. Yamaguchi et al. further dissect the mechanism of regional pigmentation by assessing the effects of dickkopf 1 (DKK1), an antagonist of the Wnt pathway produced in lightly pigmented skin, on melanocyte gene expression. The results provide a plethora of candidate genes that may mediate DKK1's inhibitory effects on melanocyte function.
Chang
Howard Y
HY
Program in Epithelial Biology, Stanford University, Stanford, California 94305, USA. howchang@stanford.edu
D005347:Fibroblasts / Q000502:physiology; D005786:Gene Expression Regulation; D038362:Glycogen Synthase Kinase 3 / Q000235:genetics / Q000502:physiology; D000071679:Glycogen Synthase Kinase 3 beta; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics / Q000502:physiology*; D008544:Melanocytes / Q000502:physiology; D012880:Skin Pigmentation / Q000502:physiology*; D051153:Wnt Proteins / Q000037:antagonists & inhibitors; D051176:beta Catenin / Q000235:genetics / Q000502:physiology
C501126:DKK1 protein, human; D036341:Intercellular Signaling Peptides and Proteins; D051153:Wnt Proteins; D051176:beta Catenin; D000071679:Glycogen Synthase Kinase 3 beta; D038362:Glycogen Synthase Kinase 3