title: Gedunin, a limonoid from Xylocarpus granatum, inhibits the growth of CaCo-2 colon cancer cell line in vitro.
abstract: Xylocarpus granatum J. König (Meliaceae), commonly known as 'dhundul', is a Bangladeshi mangrove tree, and well distributed in a number of other countries of south-east Asia, Australia and east Africa. Traditionally, X. granatum has been used as an astringent and febrifuge, and also for the treatment of fever, malaria, thrush, cholera, dysentery and diarrhoea in many countries including Bangladesh. Two limonoids, gedunin and 1alpha-hydroxy-1,2-dihydrogedunin, the latter being new, have been isolated from the bark of Xylocarpus granatum by reversed-phase preparative HPLC, and the structures were confirmed by spectroscopic means. The cytotoxic potential of gedunin has been evaluated by the Promega's CellTiter 96 non-radioactive cell proliferation assay using the CaCo-2 colon cancer cell line (IC(50) = 16.83 microM). A summary of the biological activities of gedunin reported to date is also presented.
authors: Pharmacy Discipline, University of Khulna, Khulna, Bangladesh.
authors: Shaikh J
authors: SJ
authors: Uddin
authors: Lutfun
authors: L
authors: Nahar
authors: Jamil A
authors: JA
authors: Shilpi
authors: Mohammad
authors: M
authors: Shoeb
authors: Tomasz
authors: T
authors: Borkowski
authors: Simon
authors: S
authors: Gibbons
authors: Moira
authors: M
authors: Middleton
authors: Maureen
authors: M
authors: Byres
authors: Satyajit D
authors: SD
authors: Sarker
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology*; D018938:Caco-2 Cells; D049109:Cell Proliferation / Q000187:drug effects; D003110:Colonic Neoplasms / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D036701:Limonins / Q000737:chemistry* / Q000494:pharmacology*; D029582:Meliaceae / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D036701:Limonins; C106014:gedunin