[Roles of shear stress in atherogenesis].
Located between circulating blood and vessel wall, vascular endothelial cells (ECs) are constantly exposed to shear stress resulting from blood flow. The mechanical actions of shear stress can be detected by mechanosensors on ECs and converted into specific signaling pathways to mediate the structural and functional remodeling. Patterns of shear stress may contribute to the focal distribution of atherosclerotic lesions. Here, we review recent advances regarding the roles of shear stress in atherogenesis.
Tang
Zhi-Hui
ZH
Institution of Cardiovascular Science, Peking University, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Beijing 100083, China.
Wang
Nan-Ping
NP
Shu
Chien
C
D000818:Animals; D050197:Atherosclerosis / Q000209:etiology* / Q000503:physiopathology*; D001783:Blood Flow Velocity / Q000502:physiology; D004730:Endothelium, Vascular / Q000502:physiology*; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D033081:Shear Strength; D013314:Stress, Mechanical