title: Neonatal lupus.
abstract: An otherwise healthy 5-week-old infant with erythematous plaques predominantly on the face and scalp presented to our dermatology clinic. The mother had been diagnosed with lupus erythematosus 2 years earlier but her disease was quiescent. Neonatal lupus is a rare condition associated with transplacental transfer of IgG anti-SSA/Ro and anti-SSB/La antibodies from the mother to the fetus. Active connective tissue disease in the mother does not have to be present and in fact is often absent. Although the cutaneous, hematologic and hepatic manifestations are transient, the potential for permanent heart block makes it necessary for this to be carefully ruled out. As in this case, the dermatologist may be the one to make the diagnosis and should be aware of the clinical presentation, work-up, and management of this important disease.
authors: Department of Medicine, Division of Dermatology, University of Washington Medical Center, Seattle, WA 98105, USA.
authors: David T
authors: DT
authors: Robles
authors: Lorena
authors: L
authors: Jaramillo
authors: Robin L
authors: RL
authors: Hornung
mesh_terms: D001323:Autoantibodies / Q000097:blood / Q000276:immunology; D005148:Facial Dermatoses / Q000276:immunology; D005260:Female; D006801:Humans; D007223:Infant; D018445:Infectious Disease Transmission, Vertical; D008177:Lupus Vulgaris / Q000150:complications / Q000175:diagnosis* / Q000276:immunology* / Q000635:transmission
chemical_list: D001323:Autoantibodies