[Injection of saline into unilateral central piriform cortex inhibits amygdaloid-kindled seizures in rats].
To investigate the effect of microinjection of saline into unilateral central piriform cortex (cPC) on the generalized seizures in amygdaloid-kindled rats.



Different volumes of saline were injected into the right or left cPC of amygdaloid-kindled rats, and its effect on generalized seizures was observed.



Saline injection at different volumes 0.1 microl, 0.25 microl and 1 microl) significantly decreased the incidence and duration of generalized seizures (P<0.05), the anticonvulsant effect lasted for up to 10 d. In addition, 10 min after ipsilateral injection of saline the generalized seizure thresholds were significantly increased; while this effect was observed 30 min later when contralateral injection was used.



Unilateral saline injection into cPC has a significant anticonvulsant effect, which might be used for treatment of human temporal lobe epilepsy in the future.
Zhu
Yuan-Yuan
YY
Department of Pharmacology, College of Medicine, Zhejiang University, Hangzhou 310058, China.
Zhu-Ge
Zheng-Bing
ZB
Wang
Shuang
S
Yang
Li-Xia
LX
Chen
Zhong
Z
D000679:Amygdala / Q000187:drug effects* / Q000503:physiopathology; D000818:Animals; D000927:Anticonvulsants / Q000008:administration & dosage / Q000378:metabolism; D002540:Cerebral Cortex / Q000187:drug effects / Q000503:physiopathology; D004558:Electric Stimulation; D004829:Epilepsy, Generalized / Q000503:physiopathology / Q000517:prevention & control*; D007696:Kindling, Neurologic / Q000187:drug effects*; D008297:Male; D008845:Microinjections; D051381:Rats; D017207:Rats, Sprague-Dawley; D012965:Sodium Chloride / Q000008:administration & dosage*
D000927:Anticonvulsants; D012965:Sodium Chloride