title: The metabolic consequences of sleep deprivation.
abstract: The prevalence of diabetes and obesity is increasing at an alarming rate worldwide, and the causes of this pandemic are not fully understood. Chronic sleep curtailment is a behavior that has developed over the past 2-3 decades. Laboratory and epidemiological studies suggest that sleep loss may play a role in the increased prevalence of diabetes and/or obesity. Current data suggest the relationship between sleep restriction, weight gain and diabetes risk may involve at least three pathways: (1) alterations in glucose metabolism; (2) upregulation of appetite; and (3) decreased energy expenditure. The present article reviews the current evidence in support of these three mechanisms that might link short sleep and increased obesity and diabetes risk.
authors: Department of Medicine, University of Chicago, 5841 S. Maryland Ave, MC 1027, Chicago, IL 60637, USA. kknutson@health.bsd.uchicago.edu
authors: Kristen L
authors: KL
authors: Knutson
authors: Karine
authors: K
authors: Spiegel
authors: Plamen
authors: P
authors: Penev
authors: Eve
authors: E
authors: Van Cauter
mesh_terms: D001786:Blood Glucose / Q000502:physiology; D015992:Body Mass Index; D002908:Chronic Disease; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology; D005247:Feeding Behavior; D006801:Humans; D009765:Obesity / Q000453:epidemiology; D015995:Prevalence; D012307:Risk Factors; D012892:Sleep Deprivation / Q000453:epidemiology* / Q000378:metabolism*
chemical_list: D001786:Blood Glucose