title: Effects of selective cochlear toxicity and vestibular deafferentation on vestibular evoked myogenic potentials in guinea pigs.
abstract: CONCLUSIONS
  The findings suggest that sound-evoked myogenic potentials on the guinea pig sternocleidomastoid muscle (SM) originate from the vestibular end organ and not from the cochlea of the inner ear.
  
  
  OBJECTIVE
  Studies in animals of the sound evoked vestibular myogenic potentials on the SM should aid in elucidating the pathway of the vestibular-evoked myogenic potential (VEMP). However, details of the pathway of the VEMP remain to be elucidated. This study aimed to clarify aspects of this pathway.
  
  
  METHODS
  In the present study, short latency biphasic myogenic potentials on the SM in guinea pigs were induced by an intense brief sound.
  
  
  RESULTS
  The thresholds of the potentials were 67 dB SPL above those of the auditory brainstem response (ABR). The potentials were eliminated by a vestibular deafferentation, but were observed after selective cochlea toxicity using an amikacin injection.
authors: Department of Otolaryngology, University of Toyama, Sugitani, Toyama, Japan. hshojaku@med.u-toyama.ac.jp
authors: Hideo
authors: H
authors: Shojaku
authors: Rui Li
authors: RL
authors: Zang
authors: Masahito
authors: M
authors: Tsubota
authors: Michiro
authors: M
authors: Fujisaka
authors: Etsuro
authors: E
authors: Hori
authors: Hisao
authors: H
authors: Nishijo
authors: Yukio
authors: Y
authors: Watanabe
mesh_terms: D000161:Acoustic Stimulation; D000344:Afferent Pathways / Q000502:physiology; D000583:Amikacin / Q000633:toxicity; D000818:Animals; D001933:Brain Stem / Q000502:physiology; D003051:Cochlea / Q000187:drug effects / Q000502:physiology*; D004576:Electromyography; D016057:Evoked Potentials, Auditory, Brain Stem / Q000502:physiology; D019054:Evoked Potentials, Motor / Q000502:physiology*; D006168:Guinea Pigs; D007273:Injections, Intramuscular; D009334:Neck Muscles / Q000294:innervation*; D011930:Reaction Time / Q000502:physiology; D012684:Sensory Thresholds / Q000502:physiology; D014725:Vestibular Nerve / Q000502:physiology*
chemical_list: D000583:Amikacin