title: Evolution of innate and adaptive effector cell functions during acute HIV-1 infection.
abstract: Early events during acute human immunodeficiency virus type 1 (HIV-1) infection are critical in determining the course of disease progression. Cells of the innate and adaptive immune responses are involved in this acute response to infection; however, little is known about the coevolution of innate and adaptive effector cell populations during the initial phase of HIV-1 infection. Here, we have characterized the development of innate natural killer (NK) cell and adaptive HIV-1-specific CD8(+) T cell function during acute HIV-1 infection. Although NK cell populations were significantly expanded during acute infection before HIV-1 seroconversion, HIV-1-specific CD8(+) T cell responses were absent or weak and were inversely correlated with the level of NK cell activity. NK cell activity was directly correlated with the level of viral replication during acute HIV-1 infection and declined rapidly in subjects who initiated highly active antiretroviral therapy, whereas NK cell activity remained elevated in subjects who did not initiate therapy. Yet, reexposure to HIV-1 antigen during treatment discontinuation in chronic infection resulted in a synchronous increase in NK and CD8(+) T cell activity. Overall, these data demonstrate that expansion of the NK cell population precedes the development of adaptive HIV-1-specific CD8(+) T cells during acute infection but that both effector cell subsets respond with similar kinetics during chronic HIV-1 infection.
authors: Partners AIDS Research Center, Infectious Disease Unit, Massachusetts General Hospital, Charlestown, MA 02129, USA.
authors: Galit
authors: G
authors: Alter
authors: Nickolas
authors: N
authors: Teigen
authors: Ryan
authors: R
authors: Ahern
authors: Hendrik
authors: H
authors: Streeck
authors: Angela
authors: A
authors: Meier
authors: Eric S
authors: ES
authors: Rosenberg
authors: Marcus
authors: M
authors: Altfeld
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology*; D017951:Antigen Presentation / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005434:Flow Cytometry; D006801:Humans; D007113:Immunity, Innate; D007371:Interferon-gamma / Q000097:blood; D007694:Killer Cells, Natural / Q000276:immunology*; D018655:Lymphocyte Count; D012016:Reference Values
chemical_list: D007371:Interferon-gamma