Conformational control of HCl co-transporter: imidazole functionalised isophthalamide vs. 2,6-dicarboxamidopyridine.
Replacement of the central isophthalamide core in a synthetic HCl receptor, with a 2,6-dicarboxamidopyridine, leads to a more preorganised molecular structure that exhibits higher chloride affinity and membrane transport flux.
Gale
Philip A
PA
School of Chemistry, University of Southampton, Southampton, UK SO17 1BJ. philip.gale@soton.ac.uk
Garric
Joachim
J
Light
Mark E
ME
McNally
Beth A
BA
Smith
Bradley D
BD
D000577:Amides / Q000737:chemistry*; D006851:Hydrochloric Acid / Q000737:chemistry*; D007093:Imidazoles / Q000737:chemistry*; D008968:Molecular Conformation; D010795:Phthalic Acids / Q000737:chemistry*; D011522:Protons; D011725:Pyridines / Q000737:chemistry*
D000577:Amides; D007093:Imidazoles; D010795:Phthalic Acids; D011522:Protons; D011725:Pyridines; C029899:imidazole; D006851:Hydrochloric Acid