title: Transplacental infection of Coxsackievirus B3 pathological findings in the fetus.
abstract: Coxsackievirus intrauterine infection has been documented mostly on the basis of indirect evidence of transplacental transmission, with neonatal manifestations ranging from asymptomatic infection to meningoencephalitis, myocarditis, and generalized sepsis. This is the first report of prenatal findings and fetoplacental pathology in a third trimester fetus with coxsackie B3 transplacental infection confirmed by molecular techniques. Prenatal ultrasound detected severe reduction of fetal movements at the 27th week. Late onset fetal akinesia deformation sequence with mild arthrogryposis, necrotic meningoencephalitis with vascular calcifications, interstitial pneumonitis, mild myocardial hypertrophy, and chronic monocytic placental villitis were the cardinal findings at fetal autopsy following interruption of the pregnancy.
authors: Department of Pathology, Medical School, National Kapodistrian University of Athens, Athens, Greece. ankon@med.uoa.gr
authors: Anastasia
authors: A
authors: Konstantinidou
authors: Hector
authors: H
authors: Anninos
authors: Nikolaos
authors: N
authors: Spanakis
authors: Xenophon
authors: X
authors: Kotsiakis
authors: Garyfallia
authors: G
authors: Syridou
authors: Athanassios
authors: A
authors: Tsakris
authors: Efstratios
authors: E
authors: Patsouris
mesh_terms: D000028:Abortion, Induced; D000328:Adult; D001176:Arthrogryposis / Q000473:pathology; D001483:Base Sequence; D001808:Blood Vessels / Q000473:pathology; D002114:Calcinosis / Q000473:pathology; D006332:Cardiomegaly / Q000473:pathology; D002824:Chorionic Villi / Q000473:pathology; D003384:Coxsackievirus Infections / Q000473:pathology* / Q000635:transmission* / Q000821:virology; D029822:Enterovirus B, Human / Q000235:genetics / Q000302:isolation & purification*; D005260:Female; D005315:Fetal Diseases / Q000473:pathology*; D005324:Fetal Movement; D005333:Fetus / Q000473:pathology*; D006651:Histocytochemistry; D006801:Humans; D018445:Infectious Disease Transmission, Vertical; D004684:Leukoencephalitis, Acute Hemorrhagic / Q000473:pathology; D017563:Lung Diseases, Interstitial / Q000473:pathology; D008969:Molecular Sequence Data; D010922:Placenta Diseases / Q000473:pathology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious; D016415:Sequence Alignment; D016216:Ultrasonography, Prenatal