[A clinical study on combined serum hepatic fibrosis-related markers and ultrasound parameters to diagnose hepatic fibrosis].
OBJECTIVE
This study attempted to explore the value of combining serum hepatic fibrosis-related markers and ultrasound parameters together on diagnosis of hepatic fibrosis.


METHODS
Six serum markers and 8 ultrasound parameters were measured from 100 patients with chronic hepatitis B or cirrhosis. The results of the serum hepatic fibrosis-related markers and ultrasound in disease group were analyzed and compared with the findings of hepatic pathology.


RESULTS
By filtrating,the group of platelet derived growth factor-BB (PDGF-BB) plus hyaluronic acid (HA) plus echo characteristics of liver parenchyma (LPEC) plus length of spleen (SL) had the highest Se and Spe, which were 90.7% and 85.4% respectively.


CONCLUSIONS
The advantageous combination of serum markers and ultrasound parameters can significantly improve Se and Spe, which is superior to any single serum index or ultrasound parameter. And it was a better non-invasive method for diagnosing hepatic fibrosis.
Yu
Jing
J
Department of the Second Internal Medicine, Henan Provincial People's Hospital, Zhengzhou 450003, China.
Jia
Chang-he
CH
Wang
Qi
Q
Xu
Po-shi
PS
Zhang
Hao
H
Zhao
Yu-qin
YQ
Shen
Quan
Q
Hao
Yan-rui
YR
Cai
Gui-fen
GF
D000293:Adolescent; D000328:Adult; D000368:Aged; D000410:Alanine Transaminase / Q000097:blood; D000077214:Becaplermin; D015415:Biomarkers / Q000097:blood*; D024061:Collagen Type III / Q000097:blood; D005260:Female; D019694:Hepatitis B, Chronic / Q000097:blood / Q000175:diagnosis* / Q000000981:diagnostic imaging; D006801:Humans; D006820:Hyaluronic Acid / Q000097:blood; D008103:Liver Cirrhosis / Q000097:blood / Q000175:diagnosis* / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D010982:Platelet-Derived Growth Factor / Q000032:analysis; D020574:Proto-Oncogene Proteins c-sis; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D019715:Tissue Inhibitor of Metalloproteinase-1 / Q000097:blood; D016212:Transforming Growth Factor beta / Q000097:blood; D018615:Ultrasonography, Doppler, Color / Q000379:methods*; D055815:Young Adult
D015415:Biomarkers; D024061:Collagen Type III; D010982:Platelet-Derived Growth Factor; D020574:Proto-Oncogene Proteins c-sis; D019715:Tissue Inhibitor of Metalloproteinase-1; D016212:Transforming Growth Factor beta; D000077214:Becaplermin; D006820:Hyaluronic Acid; D000410:Alanine Transaminase