A placebo controlled double blind clinical trial of mitomycin C in primary trabeculectomy in Ethiopian patients.
OBJECTIVE
To determine if surgery with mitomycin has an increased success rate in reducing introccular pressure after trabeculectomy in Ethiopian patients


METHODS
A double blind clinical trial using mitomycin C and placebo during primary trabeculectomy was carried out on 31 patients and 31 controls. 31 patients and 28 controls completed the study period Post operative intra ocular pressure and post operative complications were assessed


RESULTS
There was no statistically significant difference in the postoperative intra ocular pressure in both groups (p = 0.6 95% CI). However there was a statistically significant higher rate of complications in the cases when compared to the controls (p = .002 95% CI).


CONCLUSIONS
A controlled study with adequate power using different dosages of mitomycin is recommend
Girma
Taffessework
T
Courtright
Paul
P
Mengistu
Fekede
F
Tamirat
Tinebeb
T
Birhanu
Zemene
Z
D000477:Alkylating Agents / Q000008:administration & dosage* / Q000627:therapeutic use*; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000627:therapeutic use*; D016022:Case-Control Studies; D004311:Double-Blind Method; D005002:Ethiopia; D005260:Female; D005901:Glaucoma / Q000601:surgery*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage / Q000627:therapeutic use*; D011183:Postoperative Complications; D014130:Trabeculectomy / Q000379:methods*
D000477:Alkylating Agents; D000903:Antibiotics, Antineoplastic; D016685:Mitomycin