Impact of celiac autoimmunity on children with type 1 diabetes.
OBJECTIVE
Children with type 1 diabetes (T1DM) are at increased risk for celiac disease (CD); however, the benefits of screening for IgA tissue transglutaminase autoantibodies (TG), a marker for CD, are unclear.


METHODS
We compared 71 screening-identified TG+ with 63 matched TG- children with TIDM. Growth, bone density, and diabetes control measures were obtained.


RESULTS
The group was 10 +/- 3 years of age, 46% male, with TIDM for 4 +/- 3 years. Z scores for weight (0.3 +/- 1 vs 0.7 +/- 0.8, P = .024), body mass index (BMI) (0.3 +/- 0.9 vs 0.8 +/- -0.8, P = .005), and midarm circumference (0.3 +/- 1.1 vs 0.6 +/- 0.9, P = .031) were lower in the TG+ group. Bone mineral density and diabetes control measures were similar. When limiting the analysis to the 35 TG+ subjects with biopsy changes of CD, the BMI Z score was lower than the control group (0.4 +/- 0.9 vs 0.7 +/- 0.7, P = .05).


CONCLUSIONS
In children with TIDM, screening-identified evidence of CD is associated with altered body composition, but not bone mineral density or diabetes control. Further study is needed to determine the benefit of early diagnosis and treatment of CD in TIDM children.
Simmons
Jill H
JH
Barbara Davis Center for Childhood Diabetes, University of Colorado, Aurora, Colorado, USA. jill.simmons@uchsc.edu
Klingensmith
Georgeanna J
GJ
McFann
Kim
K
Rewers
Marian
M
Taylor
Jennifer
J
Emery
Lisa M
LM
Taki
Iman
I
Vanyi
Sharon
S
Liu
Edwin
E
Hoffenberg
Edward J
EJ
D001323:Autoantibodies / Q000097:blood*; D015551:Autoimmunity; D002446:Celiac Disease / Q000097:blood* / Q000150:complications / Q000175:diagnosis / Q000276:immunology*; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000150:complications*; D005260:Female; D006801:Humans; D008297:Male; D011503:Transglutaminases / Q000276:immunology
D001323:Autoantibodies; D011503:Transglutaminases