title: [T-cell rich B-cell lymphoma associated with neutrophilia and thrombocytosis].
abstract: A 49-year-old man was admitted with high-grade fever, night sweating and cervical lymphadenopathy in September 2005. On examination, both neutrophilia and thrombocytosis were noted in the peripheral blood, a bone marrow examination revealed marked both myeloid and megakaryocytic hyperplasia. The sera obtained at initial presentation showed an elevated levels of granulocyte-colony stimulating factor (G-CSF) and interleukin-6 (IL-6). A pathologic diagnosis of T-cell rich B-cell lymphoma was made based on an inguinal lymph node biopsy. Following treatment with CHOP accompanied by rituximab (R-CHOP), both the neutrophilia and thrombocytosis subsided after 3 courses of R-CHOP, resulting in a complete remission after 4 courses of chemotherapy. Neutrophilia, thrombocytosis and T-cell rich B-cell lymphoma in this patient were considerably ameliorated with chemotherapy. We report here a patient with T-cell rich B-cell lymphoma associated with both neutrophilia and thrombocytosis, suggesting that the lymphoma triggered both myeloid and megakaryocytic hyperplasia.
authors: Department of Internal Medicine, Higashi Sapporo Hospital.
authors: Hiroyuki
authors: H
authors: Kuroda
authors: Takuya
authors: T
authors: Matsunaga
authors: Sumio
authors: S
authors: Sakamaki
authors: Kazuhiko
authors: K
authors: Koike
authors: Takeshi
authors: T
authors: Terui
authors: Hiroshi
authors: H
authors: Neda
authors: Kunihiko
authors: K
authors: Ishitani
authors: Atsushi
authors: A
authors: Nobuoka
authors: Mutsumi
authors: M
authors: Sato
authors: Masaya
authors: M
authors: Kida
authors: Hideki
authors: H
authors: Watanabe
authors: Jun
authors: J
authors: Yamaguchi
authors: Yoshiro
authors: Y
authors: Niitsu
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D016179:Granulocyte Colony-Stimulating Factor / Q000097:blood; D006801:Humans; D006965:Hyperplasia; D015850:Interleukin-6 / Q000097:blood; D007964:Leukocytosis / Q000209:etiology*; D018655:Lymphocyte Count; D016393:Lymphoma, B-Cell / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology; D008297:Male; D008533:Megakaryocytes / Q000473:pathology; D008875:Middle Aged; D022423:Myeloid Cells / Q000473:pathology; D009504:Neutrophils; D013601:T-Lymphocytes; D013922:Thrombocytosis / Q000209:etiology*; D016896:Treatment Outcome
chemical_list: D015850:Interleukin-6; D016179:Granulocyte Colony-Stimulating Factor