title: Impact of celiac autoimmunity on children with type 1 diabetes.
abstract: OBJECTIVE
  Children with type 1 diabetes (T1DM) are at increased risk for celiac disease (CD); however, the benefits of screening for IgA tissue transglutaminase autoantibodies (TG), a marker for CD, are unclear.
  
  
  METHODS
  We compared 71 screening-identified TG+ with 63 matched TG- children with TIDM. Growth, bone density, and diabetes control measures were obtained.
  
  
  RESULTS
  The group was 10 +/- 3 years of age, 46% male, with TIDM for 4 +/- 3 years. Z scores for weight (0.3 +/- 1 vs 0.7 +/- 0.8, P = .024), body mass index (BMI) (0.3 +/- 0.9 vs 0.8 +/- -0.8, P = .005), and midarm circumference (0.3 +/- 1.1 vs 0.6 +/- 0.9, P = .031) were lower in the TG+ group. Bone mineral density and diabetes control measures were similar. When limiting the analysis to the 35 TG+ subjects with biopsy changes of CD, the BMI Z score was lower than the control group (0.4 +/- 0.9 vs 0.7 +/- 0.7, P = .05).
  
  
  CONCLUSIONS
  In children with TIDM, screening-identified evidence of CD is associated with altered body composition, but not bone mineral density or diabetes control. Further study is needed to determine the benefit of early diagnosis and treatment of CD in TIDM children.
authors: Barbara Davis Center for Childhood Diabetes, University of Colorado, Aurora, Colorado, USA. jill.simmons@uchsc.edu
authors: Jill H
authors: JH
authors: Simmons
authors: Georgeanna J
authors: GJ
authors: Klingensmith
authors: Kim
authors: K
authors: McFann
authors: Marian
authors: M
authors: Rewers
authors: Jennifer
authors: J
authors: Taylor
authors: Lisa M
authors: LM
authors: Emery
authors: Iman
authors: I
authors: Taki
authors: Sharon
authors: S
authors: Vanyi
authors: Edwin
authors: E
authors: Liu
authors: Edward J
authors: EJ
authors: Hoffenberg
mesh_terms: D001323:Autoantibodies / Q000097:blood*; D015551:Autoimmunity; D002446:Celiac Disease / Q000097:blood* / Q000150:complications / Q000175:diagnosis / Q000276:immunology*; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000150:complications*; D005260:Female; D006801:Humans; D008297:Male; D011503:Transglutaminases / Q000276:immunology
chemical_list: D001323:Autoantibodies; D011503:Transglutaminases