title: Reduction of ventricular tachyarrhythmia by treatment of atrial fibrillation in ICD patients with dual-chamber implantable cardioverter/defibrillators capable of atrial therapy delivery: the REVERT-AF Study.
abstract: OBJECTIVE
  The purpose of this prospective, randomized, multicentre study was to investigate whether the incidence of ventricular tachyarrhythmia can be reduced in standard implantable cardioverter/defibrillator (ICD) patients by implanting a dual-chamber ICD capable of atrial therapy delivery.
  
  
  RESULTS
  A Jewel AF or GEM III AT ICD (Medtronic Inc., Minneapolis, MN, USA) was implanted in 122 patients (62.3 +/- 10.5 years; 84.4% male; coronary artery disease 71.3%; left ventricular ejection fraction 39.7 +/- 13.6%; secondary ICD indication 91%). Overall, 31.2% of the patients had paroxysmal atrial fibrillation (AF)/atrial tachycardia (AT) before ICD implantation (n = 38). Implantable cardioverter/defibrillator therapies for AT/AF were activated and de-activated every 3 months in a cross-over study design. The mean follow-up was 18.5 +/- 7.7 months (6.29 +/- 2.2 cross-over/patient). Overall, there were 684 episodes of ventricular tachyarrhythmias in 48.4% of patients (n = 59). In 33.6% of patients (n = 41), 532 supraventricular tachyarrhythmias occurred. Activation of ICD therapies for AT/AF did not result in a reduction of ventricular tachyarrhythmias (P = 0.92). Patients with monomorphic ventricular tachycardias (mVTs) as index arrhythmia for ICD implantation or inducible mVTs in the electrophysiological study had the highest probability of recurrences of ventricular tachyarrhythmias.
  
  
  CONCLUSIONS
  For patients with standard indications for ICD therapy and no indication for cardiac pacing, a dual-chamber ICD capable of atrial tachyarrhythmia treatment offers no benefit concerning a reduction of ventricular tachyarrhythmias.
authors: Department of Cardiology and Angiology, University Hospital Münster, D-48129 Münster, Germany. gradaus@uni-muenster.de
authors: Rainer
authors: R
authors: Gradaus
authors: Karlheinz
authors: K
authors: Seidl
authors: Thomas
authors: T
authors: Korte
authors: Ewald
authors: E
authors: Himmrich
authors: Heinrich
authors: H
authors: Wieneke
authors: Andreas
authors: A
authors: Schuchert
authors: Wolfgang
authors: W
authors: Bauer
authors: Joachim
authors: J
authors: Gerss
authors: Christian G
authors: CG
authors: Wollmann
authors: Martin
authors: M
authors: Borggrefe
authors: Dirk
authors: D
authors: Böcker
mesh_terms: D001281:Atrial Fibrillation / Q000628:therapy*; D002304:Cardiac Pacing, Artificial; D017147:Defibrillators, Implantable; D005260:Female; D005858:Germany; D006801:Humans; D008297:Male; D008875:Middle Aged; D016012:Poisson Distribution; D011446:Prospective Studies; D017180:Tachycardia, Ventricular / Q000517:prevention & control*; D016896:Treatment Outcome