Increased concentration of soluble CD40 ligand in preeclampsia.
Preeclampsia has been associated with increased platelet activation detected before disease onset. Platelets are involved in hemostasis and also directly initiate an inflammatory response of the vessel wall. Inappropriate activation of platelets may be involved in pathogenesis in preeclampsia by promoting coagulation and thrombosis, and also as a mediator of inflammation. Platelets may release inflammatory mediators such as soluble CD40 ligand. The plasma level of soluble CD40 ligand was investigated during preeclamptic (n =20) and normal pregnancies (n = 20) to emphasize inflammatory response in preeclampsia. The mean soluble CD40 ligand levels were 1.08 +/- 0.43 ng/mL in patients with preeclampsia and 0.76 +/- 0.24 ng/mL in healthy pregnant women, which was statistically significant (P = .01). To clarify whether inflammation may cause inappropriate endothelial cell activation or inappropriate endothelial cell activation may start this inflammatory response, future studies are needed in a larger study population.
Alacacioglu
Inci
I
Department of Haematology, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey. inci074@yahoo.com
Ozcan
Mehmet Ali
MA
Piskin
Ozden
O
Yuksel
Faize
F
Alacacioglu
Ahmet
A
Demirkan
Fatih
F
Ozsan
Hayri Guner
HG
Polat
Mesut
M
Ozgenc
Yigit
Y
Undar
Bulent
B
D000328:Adult; D023201:CD40 Ligand / Q000097:blood*; D005260:Female; D006801:Humans; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D012995:Solubility
D023201:CD40 Ligand