title: [Mismatch negativity and conscience level in severe traumatic brain injury].
abstract: BACKGROUND
  The mismatch negativity (MMN) is a component of the long-latency auditory evoked potentials, that are used to check the functionality of automatic attentional processes of attentive information processing. Vegetative state diagnosis is frequent following severe traumatic brain injury (TBI). Eventually, some patients improve their condition to another one called minimal conscientious state.
  
  
  OBJECTIVE
  To evaluate the diagnostic usefulness of MMN in severe TBI patients during the subacute phase after leaving the neurological intensive care unit.
  
  
  METHODS
  We gathered MMN results from 19 patients (12 males and 7 females; 8 vegetative state and 11 minimal conscientious state) with ages between 17 and 59 years (mean: 27.3 years). The delay between TBI onset and MMN recordings were greater than 2 months (mean: 181 days). During the recording session, patients were evaluated by means of the Multisociety Task Force on Persistent Vegetative State scale.
  
  
  RESULTS
  All the minimal conscientious state patients (100%) showed MMN potential. In seven of the vegetative state patients (87.5%) the MMN was not found. The remaining MMN potential positive vegetative state patient improved to MCS 16 days after testing.
  
  
  CONCLUSIONS
  MMN is a valid tool for differentiating vegetative state from MCS during the subacute phase of severe TBI. Hence it is a useful aid to the clinical evaluation. This would diminish the impact of a possible diagnostic error and its prognosis on therapeutical management, family and health costs. It can also be used for evaluating other brain disorders with altered consciousness.
authors: Unidad Asistencial San Vicente, Neurologia, Neurofisiologia y Rehabilitacion Cerebral, Madrid, Spain. dzarza@hotmail.com
authors: D
authors: D
authors: Zarza-Luciáñez
authors: S
authors: S
authors: Arce-Arce
authors: H
authors: H
authors: Bhathal
authors: F
authors: F
authors: Sanjuán-Martín
mesh_terms: D000293:Adolescent; D000328:Adult; D001930:Brain Injuries / Q000175:diagnosis / Q000503:physiopathology*; D003243:Consciousness / Q000502:physiology*; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018458:Persistent Vegetative State / Q000175:diagnosis / Q000503:physiopathology