title: [Effect of clearing heat and removing dampness method on formation of pigment gallstones in rabbits].
abstract: OBJECTIVE
  To observe dynamically the effect of drugs for clearing heat and removing dampness (CHRD) on biliary components in rabbits with pigment gallstones (PGS).
  
  
  METHODS
  Forty rabbits were established into PGS model and randomly divided into 3 groups, the bacterial infection group, the CHRD low-dose group and the CHRD high-dose group. Besides, a normal group was set up with healthy rabbits for control. Changes of total bilirubin (TB), unconjugated bilirubin (UCB), total bile acid (TBA), Ca2+, bacterial and endogenous beta-glucuronidase (beta-Gase) in bile were observed.
  
  
  RESULTS
  CHRD drugs significantly decreased the contents of UCB, Ca2+, bacterial and endogenous beta-Gase (P < 0.05), and increased TBA in bile (P < 0.05).
  
  
  CONCLUSIONS
  CHRD drugs have good effect in reducing the lithogenesis of the pigment gallstones.
authors: Tianjin Medical University.
authors: Xi-bo
authors: XB
authors: Zhang
authors: Nai-qiang
authors: NQ
authors: Cui
authors: Dong-hua
authors: DH
authors: Li
mesh_terms: D000818:Animals; D001646:Bile / Q000187:drug effects / Q000378:metabolism; D001654:Bile Pigments / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D042882:Gallstones / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D005966:Glucuronidase / Q000378:metabolism; D008297:Male; D008517:Phytotherapy; D011817:Rabbits; D011897:Random Allocation; D016896:Treatment Outcome
chemical_list: D001654:Bile Pigments; D004365:Drugs, Chinese Herbal; D005966:Glucuronidase; D002118:Calcium