[Clinical control study of dialysates with different concentrations of calcium on blood pressure in patients under hemodialysis for prolonged period].
OBJECTIVE
To investigate the changes in blood pressure in hemodialysis patients treated with low calcium dialysate or high calcium dialysate for long time.


METHODS
Fifteen patients undergoing hemodialysis were enrolled in this study. High calcium dialysate (1.75 mmol/L, Dca1.75) was first used for 6 months, then low calcium dialysate (1.25 mmol/L, Dca1.25) was used for 6 months. Serum calcium, phosphate, blood urea nitrogen, and creatinine were measured, blood pressure was recorded before and after hemodialysis at the beginning, and also at 1, 2, 3 and 4 hours after hemodialysis.


RESULTS
Compared with that before the treatment, systolic and diastolic blood pressure lowered significantly after single low calcium hemodialysis for 4 hours (both P<0.05), while systolic and diastolic blood pressure rose significantly after single high calcium hemodialysis (both P<0.05). Systolic blood pressure changed more obviously after two hemodialyses (both P<0.05). Changes in systolic, diastolic and mean blood pressure were positively related to changes in serum total calcium (r(1)=0.326, P(1)=0.054; r(2)=0.383, P(2)=0.037; r(3)=0.391, P(3)=0.032). During 6 months of hemodialysis with low calcium dialysate, blood pressure lowered slightly with no significant difference in it (P>0.05), while systolic blood pressure rose during 6 months of hemodialysis with high calcium dialysate (P<0.05). Changes in systolic blood pressure were significantly different between two groups using dialysates with different calcium concentrations (P<0.05).


CONCLUSIONS
Systolic blood pressure and incidence of hypertension decrease after single low calcium hemodialysis.
Wang
Cheng
C
Department of Nephrology, The Third Hospital Affiliated to Sun Yat-sen University, Guangzhou, Guangdong, China. wcgz@medmail.com.cn
Lou
Tan-Qi
TQ
Chen
Zhu-Jiang
ZJ
Tang
Hua
H
Shi
Cheng-Gang
CG
Yu
Xue-Qing
XQ
Yin
Pei-da
PD
D001794:Blood Pressure / Q000187:drug effects* / Q000502:physiology; D002118:Calcium / Q000008:administration & dosage / Q000494:pharmacology*; D015314:Dialysis Solutions / Q000737:chemistry*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000209:etiology / Q000517:prevention & control; D008297:Male; D006435:Renal Dialysis / Q000009:adverse effects
D015314:Dialysis Solutions; D002118:Calcium