Effect of personality type on pharmacodynamics through changing pharmacokinetics.
A few studies have showed that there is an association between the genetic polymorphisms of drug-metabolizing enzyme, CYP2D6, to persons with different personality type. More and more evidences suggested that personality type is kind of behavioral or psychological factor which might influence the pharmacodynamics as well as patient's gender, age, disease, and genetic background. We hypothesized that personality affect the pharmacodynamics through changing pharmacokinetic mediated by different polymorphism of drug-metabolizing enzymes. Since many major diseases, from cancer to infectious disease, are involved with risky Type A personality, we appeal for attention to the clinical pharmacologist and psychiatrists further to study personality pharmacokinetics for individualized medicine.
Xu
Feng
F
Department of Clinical Pharmacology, Second Medical College, Southern Medical University, Guangzhou, China. fxu@clemson.edu
D019389:Cytochrome P-450 CYP2D6 / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics* / Q000523:psychology*; D006801:Humans; D008954:Models, Biological; D008960:Models, Psychological; D010551:Personality; D010599:Pharmacokinetics
D019389:Cytochrome P-450 CYP2D6