Common aging pathways in worms, flies, mice and humans.
Development of functional genomics tools has made it possible to define the aging process by performing genome-wide scans for transcriptional differences between the young and the old. Global screens for age regulation have been performed for worms and flies, as well as many tissues in mice and humans. Recent work has begun to analyze the similarities and differences in transcriptional changes in aging among different species. Most age-related expression changes are specific for a given species, but genes in one pathway (the electron transport chain pathway) show common age regulation in species from worms to humans. Evolutionary theories of aging provide a basis to understand how age regulation of a genetic pathway might be preserved between distantly related species.
Kim
Stuart K
SK
Department of Developmental Biology and Genetics, Stanford University Medical Center, Stanford, CA 94305-5329, USA. kim@cmgm.stanford.edu
D000367:Age Factors; D000375:Aging / Q000235:genetics*; D000818:Animals; D005075:Biological Evolution; D017173:Caenorhabditis elegans; D004331:Drosophila melanogaster; D045222:Electron Transport Chain Complex Proteins / Q000235:genetics / Q000378:metabolism*; D020869:Gene Expression Profiling / Q000379:methods*; D023281:Genomics / Q000379:methods*; D006801:Humans; D051379:Mice; D012641:Selection, Genetic; D013045:Species Specificity
D045222:Electron Transport Chain Complex Proteins