Trawling for treasure: tales of T-bet.
Discovering the transcription factors that direct lineage commitment in the T helper cell was a formidable task. Laurie Glimcher describes how she and Susanne Szabo hunted down T-bet, a transcription factor that is a 'master regulator' of commitment to the T helper type 1 lineage.
Glimcher
Laurie H
LH
Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA. lglimche@hsph.harvard.edu
D002454:Cell Differentiation / Q000276:immunology; D019070:Cell Lineage / Q000502:physiology; D020825:T-Box Domain Proteins / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism*; D000098815:T-bet Transcription Factor
D020825:T-Box Domain Proteins; D000098815:T-bet Transcription Factor; D014157:Transcription Factors