title: Treatment of acute mania with ambient air anionization: variants of climactic heat stress and serotonin syndrome.
abstract: High concentrations of ambient anions (O2-) were used to augment treatment for 20 acutely manic male patients. Anions were produced by an anion generator in a sealed room. A double-blind crossover design was used, and responses were evaluated with the Brief Psychiatric Rating Scale by 2 blinded raters. This produced a significant antimanic effect: total rating scores declined with anion treatment. Presham and postsham total scores for these 5 were 31.3 and 31.6, respectively. Pretreatment and posttreatment total scores were 31.6 and 26.3, respectively. Previous research indicates a role for serotonin in producing this antimanic effect.
authors: Ohio State University Columbus, Ohio, USA.
authors: A James
authors: AJ
authors: Giannini
authors: Jocelyn D
authors: JD
authors: Giannini
authors: Steven
authors: S
authors: Melemis
authors: Juliette N
authors: JN
authors: Giannini
mesh_terms: D000208:Acute Disease; D000328:Adult; D000390:Air Ionization; D000838:Anions; D001272:Atmosphere; D001714:Bipolar Disorder / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy*; D018882:Heat Stress Disorders / Q000453:epidemiology* / Q000523:psychology; D006801:Humans; D008297:Male; D015588:Observer Variation; D020230:Serotonin Syndrome / Q000453:epidemiology* / Q000523:psychology; D011795:Surveys and Questionnaires
chemical_list: D000838:Anions