Drug delivery systems for the treatment of sensorineural hearing loss.
Sensorineural hearing loss is one of the most common disabilities in our society. Experimentally, many candidates for therapeutic molecules have been discovered. However, the lack of safe and effective methods for drug delivery to the cochlea has been a considerable obstacle to clinical application. Local application of therapeutic molecules into the cochlea has been used in clinic and in animal experiments. Advances in pharmacological technology provide various drug delivery systems via biomaterials, which can be utilized for local drug delivery to the cochlea. Recent studies in the field of otology have demonstrated the potential of synthetic and natural biomaterials for local drug delivery to the cochlea. Although problems still remain to be resolved for clinical application, introduction into clinical practice of these controlled-release systems may be reasonable because of their certain advantages over previous methods.
Nakagawa
Takayuki
T
Department of Otolaryngology-Head and Neck Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan. tnakagawa@ent.kuhp.kyoto-u.ac.jp
Ito
Juichi
J
D000287:Administration, Topical; D001672:Biocompatible Materials / Q000008:administration & dosage / Q000627:therapeutic use*; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems / Q000295:instrumentation*; D006319:Hearing Loss, Sensorineural / Q000188:drug therapy*; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000627:therapeutic use*; D019344:Lactic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D011100:Polyglycolic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers / Q000008:administration & dosage / Q000627:therapeutic use*; D012833:Siloxanes / Q000008:administration & dosage / Q000627:therapeutic use*
D001672:Biocompatible Materials; D003692:Delayed-Action Preparations; D011108:Polymers; D012833:Siloxanes; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D011100:Polyglycolic Acid; D019344:Lactic Acid