title: Predictive value of brain perfusion SPECT for ketamine response in hyperalgesic fibromyalgia.
abstract: OBJECTIVE
  Ketamine has been used successfully in various proportions of fibromyalgia (FM) patients. However, the response to this specific treatment remains largely unpredictable. We evaluated brain SPECT perfusion before treatment with ketamine, using voxel-based analysis. The objective was to determine the predictive value of brain SPECT for ketamine response.
  
  
  METHODS
  Seventeen women with FM (48 +/- 11 years; ACR criteria) were enrolled in the study. Brain SPECT was performed before any change was made in therapy in the pain care unit. We considered that a patient was a good responder to ketamine if the VAS score for pain decreased by at least 50% after treatment. A voxel-by-voxel group analysis was performed using SPM2, in comparison to a group of ten healthy women matched for age.
  
  
  RESULTS
  The VAS score for pain was 81.8 +/- 4.2 before ketamine and 31.8 +/- 27.1 after ketamine. Eleven patients were considered "good responders" to ketamine. Responder and non-responder subgroups were similar in terms of pain intensity before ketamine. In comparison to responding patients and healthy subjects, non-responding patients exhibited a significant reduction in bilateral perfusion of the medial frontal gyrus. This cluster of hypoperfusion was highly predictive of non-response to ketamine (positive predictive value 100%, negative predictive value 91%).
  
  
  CONCLUSIONS
  Brain perfusion SPECT may predict response to ketamine in hyperalgesic FM patients.
authors: Service Central de Biophysique et de Médecine Nucléaire, Assistance Publique des Hôpitaux de Marseille, Centre Hospitalo-Universitaire de la Timone, 264 rue Saint Pierre, 13385 Marseille Cedex 5, France. eric.guedj@ap-hm.fr
authors: Eric
authors: E
authors: Guedj
authors: Serge
authors: S
authors: Cammilleri
authors: Cecile
authors: C
authors: Colavolpe
authors: David
authors: D
authors: Taieb
authors: Catherine
authors: C
authors: de Laforte
authors: Jean
authors: J
authors: Niboyet
authors: Olivier
authors: O
authors: Mundler
mesh_terms: D000328:Adult; D000368:Aged; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D015331:Cohort Studies; D005260:Female; D005356:Fibromyalgia / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000473:pathology*; D006801:Humans; D007649:Ketamine / Q000378:metabolism*; D008875:Middle Aged; D015609:Organotechnetium Compounds / Q000737:chemistry; D010477:Perfusion; D011237:Predictive Value of Tests; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D015609:Organotechnetium Compounds; D007649:Ketamine