title: [Antineutrophil cytoplasmic antibody (Anca)-associated autoimmune disease induced by propylthiouracil].
abstract: Antithyroid drugs sometimes cause severe complications. Propylthiouracil (PTU) can be associated to ANCA positive vasculitis, most often related to myeloperoxidase subtype (ANCA-MPO). Our objective is to describe a female patient with Graves' disease, who developed PTU induced-autoimmune disease, with cutaneous, pulmonary, and renal lesions, associated with ANCA. Histopathological examination revealed diffuse pulmonary hemorrhage, and focal segmental glomerulosclerosis at the kidney biopsy. She was treated with systemic corticosteroid therapy and cyclophosphamide, with clinical improvement. This case highlights the need for greater awareness of this relatively rare adverse effect of propylthiouracil.
authors: Serviço de Endocrinologia e Metabologia, Universidade Federal do Paraná, Curitiba, PR.
authors: Nádila Cecyn
authors: NC
authors: Pietszkowski
authors: Gisah Amaral de
authors: GA
authors: Carvalho
authors: Hevelyn Noemberg de
authors: HN
authors: Souza
authors: Cláudio Rogério
authors: CR
authors: Werka
authors: Luís Augusto
authors: LA
authors: Borazo
authors: Hans
authors: H
authors: Graf
authors: Mauricio de
authors: Md
authors: Carvalho
mesh_terms: D000328:Adult; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood*; D013956:Antithyroid Agents / Q000009:adverse effects*; D001327:Autoimmune Diseases / Q000139:chemically induced* / Q000276:immunology; D005260:Female; D006111:Graves Disease / Q000188:drug therapy / Q000276:immunology; D006801:Humans; D007155:Immunologic Factors / Q000276:immunology; D009195:Peroxidase / Q000276:immunology*; D011441:Propylthiouracil / Q000009:adverse effects*; D014657:Vasculitis / Q000139:chemically induced* / Q000276:immunology
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D013956:Antithyroid Agents; D007155:Immunologic Factors; D011441:Propylthiouracil; D009195:Peroxidase