title: Ameloblastic carcinoma: an analysis of 14 cases.
abstract: OBJECTIVE
  To present the classifications of malignant ameloblastomas, provide histopathologic guidelines for the diagnosis of ameloblastic carcinoma, and discuss treatment and long-term follow-up.
  
  
  METHODS
  Fourteen archival specimens of ameloblastic carcinoma with detailed treatment and follow-up documentation were identified by the authors.
  
  
  RESULTS
  Traditional methods of microscopic observation form the basis for diagnosis. Histopathologic features of ameloblastic carcinoma include lack of differentiation, hypercellularity, high mitotic index, vascular invasion, and neural invasion.
  
  
  CONCLUSIONS
  The long-term follow-up findings in this study support the concept that aggressive surgical intervention provides the best chance for survival. Patients treated otherwise had recurrence. The patients with the highest number of recurrences did not survive the disease.
authors: Division of Anatomic Pathology, Mayo Clinic, Rochester, MN 55905, USA.
authors: James M
authors: JM
authors: Hall
authors: Dwight R
authors: DR
authors: Weathers
authors: K Krishnan
authors: KK
authors: Unni
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008339:Mandibular Neoplasms / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D008441:Maxillary Neoplasms / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009808:Odontogenic Tumors / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D012189:Retrospective Studies; D016896:Treatment Outcome