title: Discovery of 1-(4-phenoxypiperidin-1-yl)-2-arylaminoethanone stearoyl-CoA desaturase 1 inhibitors.
abstract: A series of novel stearoyl-CoA desaturase 1 (SCD1) inhibitors were identified by scaffold design based on known SCD1 inhibitors. Large structural changes were made leading to multiple analogs with comparable or improved potency. This approach is valuable for generation of proprietary compounds without conducting a costly high-throughput screening.
authors: Metabolic Disease Research, Global Pharmaceutical Research and Development, R4MC, AP-10, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064-6098, USA. zhao_hongyu@hotmail.com
authors: Hongyu
authors: H
authors: Zhao
authors: Michael D
authors: MD
authors: Serby
authors: Harriet T
authors: HT
authors: Smith
authors: Ning
authors: N
authors: Cao
authors: Tom S
authors: TS
authors: Suhar
authors: Teresa K
authors: TK
authors: Surowy
authors: Heidi S
authors: HS
authors: Camp
authors: Christine A
authors: CA
authors: Collins
authors: Hing L
authors: HL
authors: Sham
authors: Gang
authors: G
authors: Liu
mesh_terms: D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology*; D005021:Ethylamines / Q000138:chemical synthesis / Q000494:pharmacology*; D010880:Piperidines / Q000138:chemical synthesis / Q000494:pharmacology*; D013230:Stearoyl-CoA Desaturase / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship; D013379:Substrate Specificity
chemical_list: D004791:Enzyme Inhibitors; D005021:Ethylamines; D010880:Piperidines; D013230:Stearoyl-CoA Desaturase