The dumb ErbB receptor helps healing.
ErbB3 receptor is a member of the epidermal growth factor (EGF) receptor (ErbB1) family. Okwueze et al. have transfected this receptor in a pig model of wounds and demonstrate that it accelerates the resurfacing of the wounds when combined with epiregulin or heparin-binding EGF. Currently, only hypotheses can be proposed to explain the observations.
Poumay
Yves G
YG
Cell and Tissue Laboratory, Faculty of Medicine, University of Namur, Namur, Belgium. yves.poumay@fundp.ac.be
D000818:Animals; D049109:Cell Proliferation; D004815:Epidermal Growth Factor / Q000502:physiology; D066260:Epiregulin; D066257:Heparin-binding EGF-like Growth Factor; D036341:Intercellular Signaling Peptides and Proteins; D015603:Keratinocytes / Q000502:physiology; D023421:Models, Animal; D020893:Receptor, ErbB-3 / Q000502:physiology*; D013552:Swine; D014945:Wound Healing / Q000502:physiology*
D066260:Epiregulin; D066257:Heparin-binding EGF-like Growth Factor; D036341:Intercellular Signaling Peptides and Proteins; D004815:Epidermal Growth Factor; D020893:Receptor, ErbB-3