title: [Preparation of inclusion complex of paeonol and beta-cyclodextrin by sealed-control temperature method].
abstract: OBJECTIVE
  In the present study, using paeonol as model drug, a new sealed-control temperature method of preparing inclusion complex was developed, the effects of heating temperature, heating time, and crystallinity of beta-cyclodextrin (beta-CD) on formation of inclusion complex and release of the drug were investigated.
  
  
  METHODS
  A physical mixture of paeonol and beta-CD was sealed in a container, and heated at the desired temperature for the specified time. The inclusion complex of paeonol and beta-CD was confirmed by IR spectrum and powder X-ray diffraction.
  
  
  RESULTS
  The results indicated that the inclusion complex formation of paeonol beta-CD by sealed-control temperature method was affected by heating temperature, heating time, and crystallinity of beta-CD. The inclusion complex was able to inhibit sublimation of paeonol, and dissolution rate of paeonol was increased when the paeonol was included by beta-CD.
  
  
  CONCLUSIONS
  Preparation of inclusion complex was simple and quick by sealed-control temperature method.
authors: School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China. oshwang@sina.com
authors: Qi-fang
authors: QF
authors: Wang
authors: Xiao-wen
authors: XW
authors: Fan
authors: Lu
authors: L
authors: Xu
authors: Yu
authors: Y
authors: Yao
mesh_terms: D000098:Acetophenones / Q000737:chemistry*; D003460:Crystallization; D004339:Drug Compounding / Q000379:methods*; D006358:Hot Temperature; D012995:Solubility; D013055:Spectrophotometry, Infrared; D013696:Temperature; D014961:X-Ray Diffraction; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D000098:Acetophenones; D047392:beta-Cyclodextrins; C013638:paeonol