title: Clinical course in Crohn's disease: results of a five-year population-based follow-up study (the IBSEN study).
abstract: BACKGROUND
  There are few population-based, prospective studies on the clinical course in patients with Crohn's disease (CD).
  
  
  OBJECTIVE
  To extend the observation period in a population-based prospective study (the IBSEN study) to find out more about the initial 5-year clinical course in CD patients and to relate the findings to the Vienna classification.
  
  
  METHODS
  All patients diagnosed with inflammatory bowel disease (IBD) in southeastern Norway in the 4 years 1990-1993 were followed prospectively. The patients were invited to a systematic follow-up visit at their local hospital 1 and 5 years after inclusion in the study. The visits included a structured interview, a clinical examination and colonoscopy.
  
  
  RESULTS
  Out of 843 patients initially diagnosed with IBD, 200 patients with definite CD were alive and had sufficient data for analysis 5 years after diagnosis. Changes in disease localization and behaviour in relation to the Vienna classification were observed in 27 (13.5%) and 35 patients (17.5%), respectively. During the observation period, 56 patients (28%) underwent surgery with intestinal resection, and half of these had disease localized in the terminal ileum. At the time of the 5-year visit, oral sulfasalazin and 5-aminosalicylic acid (5-ASA) were the most frequently used medications (by 54% of the patients), while oral glucocorticosteroids and azathioprine were being used by 25% and 13%, respectively. Seventy-two percent of the patients had taken oral glucocorticosteroids at some time in the course of the 5-year period. The majority of the patients had intestinal symptoms at 5 years, but only 16% had symptoms that interfered with everyday activities. Fourteen percent of the patients had had a relapse-free 5-year course; however, relapse was not related to the initial Vienna classification. When the patients described the clinical course, 44% reported an improvement in symptoms during the follow-up period.
  
  
  CONCLUSIONS
  The 5-year clinical course in an unselected cohort of CD patients was mostly mild. The frequency of surgery was lower than that observed in other studies and only a minority of the patients had symptoms that interfered with everyday activities 5 years after the initial diagnosis. The Vienna classification predicted the risk of surgery, but did not predict symptoms at 5 years, relapses during the observation period or the course of disease as described by the patients.
authors: Department of Internal Medicine, Østfold Hospital Moss, and Aker University Hospital, Oslo, Norway. maghen@online.no
authors: Magne
authors: M
authors: Henriksen
authors: Jørgen
authors: J
authors: Jahnsen
authors: Idar
authors: I
authors: Lygren
authors: Erling
authors: E
authors: Aadland
authors: Tom
authors: T
authors: Schulz
authors: Morten H
authors: MH
authors: Vatn
authors: Bjørn
authors: B
authors: Moum
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D003113:Colonoscopy / Q000379:methods; D003424:Crohn Disease / Q000175:diagnosis* / Q000453:epidemiology / Q000628:therapy; D013505:Digestive System Surgical Procedures / Q000379:methods; D018450:Disease Progression; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000008:administration & dosage; D006801:Humans; D008297:Male; D008875:Middle Aged; D009017:Morbidity / Q000639:trends; D009664:Norway / Q000453:epidemiology; D011159:Population Surveillance; D011379:Prognosis; D011446:Prospective Studies; D012720:Severity of Illness Index; D013997:Time Factors
chemical_list: D005938:Glucocorticoids