Scleroderma -- news to tell.
Scleroderma is a chronic fibrosing disease, in which an early inflammatory reaction precedes the fibrotic response. Systematic analysis of the pathways involved in the development of the disease together with information derived from novel animal models have helped to better understand the mechanisms that trigger and sustain fibrotic reactions.
Eckes
Beate
B
Department of Dermatology, University of Cologne, Kerpener Str 62, Cologne, Germany.
Hunzelmann
Nicolas
N
Moinzadeh
Pia
P
Krieg
Thomas
T
D000818:Animals; D016207:Cytokines / Q000502:physiology; D004195:Disease Models, Animal; D005109:Extracellular Matrix / Q000502:physiology; D005355:Fibrosis / Q000188:drug therapy / Q000235:genetics / Q000503:physiopathology; D020869:Gene Expression Profiling; D006801:Humans; D051379:Mice; D012595:Scleroderma, Systemic / Q000188:drug therapy / Q000235:genetics / Q000503:physiopathology*
D016207:Cytokines