title: Resection of the mesopancreas (RMP): a new surgical classification of a known anatomical space.
abstract: BACKGROUND
  Prognosis after surgical therapy for pancreatic cancer is poor and has been attributed to early lymph node involvement as well as to a strong tendency of cancer cells to infiltrate into the retropancreatic tissue and to spread along the peripancreatic neural plexuses. The objective of our study was to classify the anatomical-surgical layer of the mesopancreas and to describe the surgical principles relevant for resection of the mesopancreas (RMP). Immunohistochemical investigation of the mesopancreatic-perineural lymphogenic structures was carried out with the purpose of identifying possible routes of metastatic spread.
  
  
  METHODS
  Resection of the mesopancreas (RMP) was performed in fresh corpses. Pancreas and mesopancreas were separated from each other and the mesopancreas was immunohistochemically investigated.
  
  
  RESULTS
  The mesopancreas strains itself dorsally of the mesenteric vessels as a whitish-firm, fatty tissue-like layer. Macroscopically, in the dissected en-bloc specimens of pancreas and mesopancreas nerve plexuses were found running from the dorsal site of the pancreatic head to the mesopancreas to establish a perineural plane. Immunohistochemical examinations revealed the lymphatic vessels localized in direct vicinity of the neuronal plexuses between pancreas and mesopancreas.
  
  
  CONCLUSIONS
  The mesopancreas as a perineural lymphatic layer located dorsally to the pancreas and reaching beyond the mesenteric vessels has not been classified in the anatomical or surgical literature before. The aim to ensure the greatest possible distance from the retropancreatic lymphatic tissue which drains the carcinomatous focus can be achieved in patients with pancreatic cancer only by complete resection of the mesopancreas (RMP).
authors: Department of General and Abdominal Surgery, Johannes Gutenberg-University of Mainz, Germany. gockel@ach.klinik.uni-mainz.de
authors: Ines
authors: I
authors: Gockel
authors: Mario
authors: M
authors: Domeyer
authors: Tanja
authors: T
authors: Wolloscheck
authors: Moritz A
authors: MA
authors: Konerding
authors: Theodor
authors: T
authors: Junginger
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002102:Cadaver; D004210:Dissection; D005260:Female; D006801:Humans; D008297:Male; D008642:Mesenteric Veins / Q000601:surgery; D009361:Neoplasm Invasiveness / Q000473:pathology*; D010179:Pancreas / Q000098:blood supply / Q000294:innervation* / Q000601:surgery*; D010180:Pancreatectomy / Q000379:methods*; D010190:Pancreatic Neoplasms / Q000473:pathology / Q000601:surgery*; D012307:Risk Factors; D012680:Sensitivity and Specificity