SPR imaging-based salivary diagnostics system for the detection of small molecule analytes.
Saliva is an underused fluid with considerable promise for biomedical testing. Its potential is particularly great for monitoring small-molecule analytes since these are often present in saliva at concentrations that correlate well with their free levels in blood. We describe the development of a prototype diagnostic device for the rapid detection of the antiepileptic drug (AED) phenytoin in saliva. The multicomponent system includes a hand-portable surface plasmon resonance (SPR) imaging instrument and a disposable microfluidic assay card.
Fu
Elain
E
Department of Bioengineering, University of Washington, Seattle, WA 98195, USA. efu@u.washington.edu
Chinowsky
Timothy
T
Nelson
Kjell
K
Johnston
Kyle
K
Edwards
Thayne
T
Helton
Kristen
K
Grow
Michael
M
Miller
John W
JW
Yager
Paul
P
D015415:Biomarkers / Q000032:analysis / Q000737:chemistry / Q000378:metabolism; D044085:Microfluidics; D012463:Saliva / Q000737:chemistry*; D020349:Surface Plasmon Resonance / Q000295:instrumentation / Q000379:methods
D015415:Biomarkers