title: [Good clinical practices and inpatient antibiotics: optimization of fluoroquinolone switch therapy].
abstract: OBJECTIVE
  Intravenous-to-oral switch therapy is strongly recommended in the medical literature. The aim of this study was to assess how we can improve fluoroquinolone switch therapy.
  
  
  METHODS
  In this comparative prospective study, we analyzed 243 intravenous ciprofloxacin treatments and assessed the impact of promoting a switch to oral step-down therapy.
  
  
  RESULTS
  This study found that switches from intravenous to oral therapy increased, mainly in medical wards, and led to significant savings in direct costs.
  
  
  CONCLUSIONS
  Promoting switch therapy has improved clinical practices in antibiotic use and led to lower direct and probably indirect drug-related costs.
  
  
  CONCLUSIONS
  Our findings will help define the role of switch therapy in improving clinical practices in inpatient antibiotic use.
authors: Service Pharmacie, CHU, Dijon. baptiste.rigaud@chu-limoges.fr
authors: Baptiste
authors: B
authors: Rigaud
authors: Charlotte
authors: C
authors: Malbranche
authors: Virginie
authors: V
authors: Pioud
authors: Audrey
authors: A
authors: Lochard
authors: Mathilde
authors: M
authors: Chemelle
authors: Hervé
authors: H
authors: Aube
authors: Aline
authors: A
authors: Lazzarotti
authors: Marie-Hélène
authors: MH
authors: Guignard
mesh_terms: D000284:Administration, Oral; D000890:Anti-Infective Agents / Q000008:administration & dosage* / Q000191:economics*; D016009:Chi-Square Distribution; D002939:Ciprofloxacin / Q000008:administration & dosage* / Q000191:economics*; D017046:Cost Savings; D003627:Data Interpretation, Statistical; D016527:Drug Costs; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D007297:Inpatients; D008297:Male; D010818:Practice Patterns, Physicians'; D011446:Prospective Studies
chemical_list: D000890:Anti-Infective Agents; D002939:Ciprofloxacin