Replication-competent HIV strains infect HIV controllers despite undetectable viremia (ANRS EP36 study).
The replicative potential of HIV-1 strains in a well-characterized group of eight HIV controllers was investigated. Replication-competent viruses were detected in CD4 T-cell co-culture supernatants from all HIV controllers. The phylogenetic analysis of C2V4 suggested viral evolution or co-infection or superinfection in two out of the four patients analysed. The vif and vpr genes were normal. Infection with HIV-1 variants with attenuated replicative capacity cannot be a general factor accounting for undetectable viraemia in HIV controllers.
Lamine
Aurelia
A
INSERM U802, Paris XI University, Bicêtre, France.
Caumont-Sarcos
Anne
A
Chaix
Marie-Laure
ML
Saez-Cirion
Asier
A
Rouzioux
Christine
C
Delfraissy
Jean-François
JF
Pancino
Gianfranco
G
Lambotte
Olivier
O
D015496:CD4-Positive T-Lymphocytes / Q000821:virology; D002478:Cells, Cultured; D015686:Gene Products, env / Q000235:genetics; D015658:HIV Infections / Q000276:immunology / Q000821:virology*; D015497:HIV-1 / Q000235:genetics / Q000472:pathogenicity / Q000502:physiology*; D006801:Humans; D010802:Phylogeny; D014766:Viremia / Q000821:virology; D014779:Virus Replication
D015686:Gene Products, env