MHC class I, II, and III microsatellite marker matching and survival in unrelated donor hematopoietic cell transplantation.
Microsatellites (Msats) are effective markers for disease association mapping. The International Histocompatibility Working Group in hematopoietic cell transplantation applied Msats to determine whether potential new transplantation determinants are encoded within the major histocompatibility complex. Retrospective analysis of human leukocyte antigen-identical unrelated donor transplants provided a homogeneous population to measure Msat-associated risks of mortality.
Malkki
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Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. mmalkki@fhcrc.org
Gooley
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Horowitz
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Petersdorf
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D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005260:Female; D005819:Genetic Markers; D006086:Graft vs Host Disease / Q000235:genetics* / Q000276:immunology; D019337:Hematologic Neoplasms / Q000235:genetics / Q000401:mortality / Q000628:therapy*; D018380:Hematopoietic Stem Cell Transplantation; D006648:Histocompatibility / Q000235:genetics*; D006801:Humans; D007223:Infant; D008285:Major Histocompatibility Complex / Q000235:genetics*; D008297:Male; D018895:Microsatellite Repeats / Q000235:genetics*; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D011379:Prognosis; D015996:Survival Rate; D014019:Tissue Donors
D005819:Genetic Markers