The initial experience of antithrombin III in the management of neonates with necrotizing enterocolitis.
BACKGROUND
Necrotizing enterocolitis (NEC), the devastating enteric process of premature neonates, is marked by severe intravascular abnormalities and disseminated intravascular coagulation. Treatment to date remains historical and continues to be merely supportive without attempts to ameliorate progress within the inflammatory or coagulation cascades. Antithrombin III (ATIII) supplementation has been shown to favorably alter the process of disseminated intravascular coagulation and sepsis in adults. However, no reported use of this treatment exists in neonates. Therefore, we analyze the efficacy of our recent experience with ATIII replacement therapy in neonates with NEC.


METHODS
Age and diseased-matched controls with NEC were identified before the introduction of ATIII in our institution and compared against neonates with NEC undergoing ATIII replacement for diminished ATIII levels. Data collected included demographics, course of treatment parameters, and outcomes. Course of treatment parameters included hemoglobin, platelet count, prothrombin time, and partial thromboplastin time over the first 10 consecutive days of treatment. Outcome variables included packed red blood cell, platelet, fresh frozen plasma, and cryoprecipitate transfusions, as well as transfusion cost, length of stay, and survival.


RESULTS
Over a 5-year period, 19 neonates with NEC received ATIII and were compared to 17 historical controls. Treatment hematologic profiles were not worsened in the ATIII-treated patients. The control patients received less overall transfusions and had a shorter length of stay.


CONCLUSIONS
Antithrombin III appears to be safe in neonates with NEC, and its impact on reversing intravascular pathology in these patients warrants more thorough investigation.
St Peter
Shawn D
SD
Department of Pediatric Surgery, Children's Mercy Hospital, Kansas City, MO 64108, USA.
Little
Danny C
DC
Calkins
Casey M
CM
Holcomb
George W
GW
Snyder
Charles L
CL
Ostlie
Daniel J
DJ
D000925:Anticoagulants / Q000627:therapeutic use*; D000990:Antithrombin III / Q000627:therapeutic use*; D001803:Blood Transfusion; D004211:Disseminated Intravascular Coagulation / Q000150:complications / Q000188:drug therapy*; D020345:Enterocolitis, Necrotizing / Q000150:complications* / Q000628:therapy; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male
D000925:Anticoagulants; D000990:Antithrombin III