Acute amlodipine overdose treated by high dose intravenous calcium in a patient with severe renal insufficiency.
Calcium salts are frequently used in the treatment of calcium antagonist poisoning. Different dosing regimens have been employed. The major risk of high dose calcium therapy is iatrogenic hypercalcemia, especially in patients with diminished renal function. Repeated doses of calcium are therefore often avoided; however, inadequate use of intravenous calcium may cause treatment failure in severe calcium antagonist overdose. We report our experience of using high dose intravenous calcium chloride effectively and safely to treat severe amlodipine overdose in a patient with severe renal insufficiency.
Hung
Yao-Min
YM
Division of Nephrology, Department of Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan. ymhung1@doctor.com
Olson
Kent R
KR
D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000188:drug therapy / Q000503:physiopathology; D000328:Adult; D017311:Amlodipine / Q000506:poisoning*; D000931:Antidotes / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D002118:Calcium / Q000627:therapeutic use*; D002121:Calcium Channel Blockers / Q000506:poisoning*; D002302:Cardiac Output / Q000187:drug effects; D002407:Catheterization, Swan-Ganz; D002606:Charcoal / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D062787:Drug Overdose; D005260:Female; D006334:Heart Function Tests; D006801:Humans; D007275:Injections, Intravenous; D011669:Pulmonary Wedge Pressure / Q000187:drug effects; D016896:Treatment Outcome; D014655:Vascular Resistance / Q000187:drug effects
D000931:Antidotes; D002121:Calcium Channel Blockers; D002606:Charcoal; D017311:Amlodipine; D002118:Calcium