title: The impact of maternal age, body mass index and maternal weight gain on the glucose challenge test in pregnancy.
abstract: OBJECTIVE
  The aim of this study was to determine whether maternal age, prepregnancy and mid-trimester body mass index (BMI), or excessive mid-pregnancy weight gain predict abnormal glucose challenge test (GCT) results.
  
  
  METHODS
  A retrospective chart review of 75 consecutive singleton pregnancies was performed. Patients were screened at 24-28 weeks of gestation with a 50-g oral GCT. Prepregnancy BMI and pregnancy weight gain up to the time of GCT testing, as well as other demographic data, were recorded. Statistical analysis included regression analysis and Student's t-test, receiver-operator characteristic curve and multivariate logistic regression.
  
  
  RESULTS
  Maternal age and prepregnancy and mid-trimester BMI were significantly higher in women with an abnormal GCT (p<0.05). A direct correlation was found between these parameters and GCT results (R(2)=0.08, R(2)=0.102 and R(2)=0.116, respectively; p<0.05). Mid-trimester maternal BMI of >or=30 kg/m(2) and maternal age >or=32 years are the optimal predictors of abnormal GCT results.
  
  
  CONCLUSIONS
  Mid-trimester maternal BMI of >or=30 kg/m(2) and maternal age >or=32 years are useful predictors of abnormal GCT results. We suggest that these factors should also be considered when selective screening for gestational diabetes mellitus is practiced.
authors: Department of Obstetrics and Gynecology, Lenox Hill Hospital, NY 10025, USA. rhackmon@gmail.com
authors: Rinat
authors: R
authors: Hackmon
authors: Richard
authors: R
authors: James
authors: Christopher
authors: C
authors: O'Reilly Green
authors: Asaf
authors: A
authors: Ferber
authors: Yoni
authors: Y
authors: Barnhard
authors: Michael
authors: M
authors: Divon
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000032:analysis*; D015992:Body Mass Index; D016640:Diabetes, Gestational / Q000097:blood / Q000175:diagnosis*; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D008423:Maternal Age; D011247:Pregnancy; D012372:ROC Curve; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D015430:Weight Gain / Q000502:physiology*
chemical_list: D001786:Blood Glucose