title: Effect of Vita Glucan on some antioxidant parameters of the human blood. In vitro study.
abstract: Recently, beta-glucan has been postulated to modulate antioxidant enzyme activity (superoxide dismutase-SOD) as well as to inhibit lipid peroxidation in studies concerning rats or rabbits. There are very few reports on antioxidant effect of beta-glucan in the human blood. The study was aimed to estimate influence of Vita Glucan (VG) on SOD and catalase (CAT) activities as well as on total antioxidant power measured as ferric reducing activity and ascorbate concentration (FRASC) in the human blood in vitro. SOD activities were measured according to Fridovich's method, CAT activity by Aebi's and FRASC value by Benzi's one. Results of this study have shown that Vita Glucan at concentrations 42.5, 85, 170, and 340 mg x 100 mL(-1) increased markedly activities of antioxidant enzymes and FRASC values in human red blood cells hemolysates.
authors: Radioligand Laboratory, Faculty of Pharmacy, Medical College, Jagiellonian University, 9 Medyczna Str., 30-688 Kraków, Poland. apietrzy1@cm-uj.krakow.pl
authors: Agata
authors: A
authors: Pietrzycka
authors: Marek
authors: M
authors: Stepniewski
authors: Anna M
authors: AM
authors: Waszkielewicz
authors: Henryk
authors: H
authors: Marona
authors: Agata
authors: A
authors: Krzyzanowska
authors: Katarzyna
authors: K
authors: Kłosowska
authors: Olaf
authors: O
authors: Solarz
mesh_terms: D002374:Catalase / Q000097:blood; D004305:Dose-Response Relationship, Drug; D006801:Humans; D013482:Superoxide Dismutase / Q000097:blood; D047071:beta-Glucans / Q000494:pharmacology*
chemical_list: D047071:beta-Glucans; D002374:Catalase; D013482:Superoxide Dismutase