title: A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity.
abstract: Obesity is a serious international health problem that increases the risk of several common diseases. The genetic factors predisposing to obesity are poorly understood. A genome-wide search for type 2 diabetes-susceptibility genes identified a common variant in the FTO (fat mass and obesity associated) gene that predisposes to diabetes through an effect on body mass index (BMI). An additive association of the variant with BMI was replicated in 13 cohorts with 38,759 participants. The 16% of adults who are homozygous for the risk allele weighed about 3 kilograms more and had 1.67-fold increased odds of obesity when compared with those not inheriting a risk allele. This association was observed from age 7 years upward and reflects a specific increase in fat mass.
authors: Genetics of Complex Traits, Institute of Biomedical and Clinical Science, Peninsula Medical School, Magdalen Road, Exeter, UK.
authors: Timothy M
authors: TM
authors: Frayling
authors: Nicholas J
authors: NJ
authors: Timpson
authors: Michael N
authors: MN
authors: Weedon
authors: Eleftheria
authors: E
authors: Zeggini
authors: Rachel M
authors: RM
authors: Freathy
authors: Cecilia M
authors: CM
authors: Lindgren
authors: John R B
authors: JR
authors: Perry
authors: Katherine S
authors: KS
authors: Elliott
authors: Hana
authors: H
authors: Lango
authors: Nigel W
authors: NW
authors: Rayner
authors: Beverley
authors: B
authors: Shields
authors: Lorna W
authors: LW
authors: Harries
authors: Jeffrey C
authors: JC
authors: Barrett
authors: Sian
authors: S
authors: Ellard
authors: Christopher J
authors: CJ
authors: Groves
authors: Bridget
authors: B
authors: Knight
authors: Ann-Marie
authors: AM
authors: Patch
authors: Andrew R
authors: AR
authors: Ness
authors: Shah
authors: S
authors: Ebrahim
authors: Debbie A
authors: DA
authors: Lawlor
authors: Susan M
authors: SM
authors: Ring
authors: Yoav
authors: Y
authors: Ben-Shlomo
authors: Marjo-Riitta
authors: MR
authors: Jarvelin
authors: Ulla
authors: U
authors: Sovio
authors: Amanda J
authors: AJ
authors: Bennett
authors: David
authors: D
authors: Melzer
authors: Luigi
authors: L
authors: Ferrucci
authors: Ruth J F
authors: RJ
authors: Loos
authors: Inês
authors: I
authors: Barroso
authors: Nicholas J
authors: NJ
authors: Wareham
authors: Fredrik
authors: F
authors: Karpe
authors: Katharine R
authors: KR
authors: Owen
authors: Lon R
authors: LR
authors: Cardon
authors: Mark
authors: M
authors: Walker
authors: Graham A
authors: GA
authors: Hitman
authors: Colin N A
authors: CN
authors: Palmer
authors: Alex S F
authors: AS
authors: Doney
authors: Andrew D
authors: AD
authors: Morris
authors: George Davey
authors: GD
authors: Smith
authors: Andrew T
authors: AT
authors: Hattersley
authors: Mark I
authors: MI
authors: McCarthy
mesh_terms: D000273:Adipose Tissue; D000293:Adolescent; D000328:Adult; D000368:Aged; D000483:Alleles; D001724:Birth Weight; D015992:Body Mass Index; D016022:Case-Control Studies; D002648:Child; D015331:Cohort Studies; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006720:Homozygote; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000235:genetics*; D050177:Overweight / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D006113:United Kingdom