Influence of diazepam on clinically designed FMRI.
The authors investigated the effect of diazepam on clinically relevant measures from functional magnetic resonance imaging (fMRI) examinations. Twenty volunteers were scanned twice. Using a double-blind randomized study design, the volunteers received placebo on one occasion, and on the other, 5 mg of diazepam. Three functional tests were used: motor, word generation, and working memory. Images were analyzed individually for each subject and the number of activated voxels and the laterality index were calculated. No significant effects related to the drug were detected. In contrast, the motor and working memory tasks showed a significant decrease in the number of activated voxels between Sessions 1 and 2, independently of diazepam administration. These results indicate that diazepam may be administered for premedication prior to fMRI investigations.
Ragnehed
Mattias
M
Department of Neuroscience and Locomotion, the Center for Medical Imaging and Visualization, Linköping University, Sweden. matra@imv.liu.se
Håkansson
Irene
I
Nilsson
Maritha
M
Lundberg
Peter
P
Söderfeldt
Birgitta
B
Engström
Maria
M
D000328:Adult; D000927:Anticonvulsants / Q000008:administration & dosage / Q000009:adverse effects*; D001921:Brain / Q000187:drug effects* / Q000503:physiopathology*; D003657:Decision Making / Q000187:drug effects; D003975:Diazepam / Q000008:administration & dosage / Q000009:adverse effects*; D004311:Double-Blind Method; D005260:Female; D007839:Functional Laterality; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008569:Memory Disorders / Q000139:chemically induced* / Q000175:diagnosis / Q000453:epidemiology; D009483:Neuropsychological Tests; D011596:Psychomotor Disorders / Q000139:chemically induced* / Q000175:diagnosis / Q000453:epidemiology; D011930:Reaction Time / Q000187:drug effects; D013997:Time Factors
D000927:Anticonvulsants; D003975:Diazepam