title: Dinuclear zinc-catalyzed enantioselective Aza-Henry reaction.
abstract: The dinuclear zinc catalyst 1a was found to catalyze the addition of nitroalkanes to carbamate-protected imines. This aza-Henry reaction proceeds with high enantioselectivity when various carbamate-protected imines are used. alpha,beta-Unsaturated imines proved to be a particularly useful class of substrate routinely giving the alpha-nitro amine products in high enantiomeric excess.
authors: Department of Chemistry, Stanford University, Stanford, CA 94305-8080, USA. bmtrost@stanford.edu
authors: Barry M
authors: BM
authors: Trost
authors: David W
authors: DW
authors: Lupton
mesh_terms: D000473:Alkanes / Q000737:chemistry; D000478:Alkylation; D001372:Aza Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D007097:Imines / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism; D017967:Zinc Compounds / Q000737:chemistry*
chemical_list: D000473:Alkanes; D001372:Aza Compounds; D007097:Imines; D017967:Zinc Compounds