title: Study progress on mechanism of severe acute pancreatitis complicated with hepatic injury.
abstract: Study on the action mechanism of inflammatory mediators generated by the severe acute pancreatitis (SAP) in multiple organ injury is a hotspot in the surgical field. In clinical practice, the main complicated organ dysfunctions are shock, respiratory failure, renal failure, encephalopathy, with the rate of hepatic diseases being closely next to them. The hepatic injury caused by SAP cannot only aggravate the state of pancreatitis, but also develop into hepatic failure and cause patient death. Its complicated pathogenic mechanism is an obstacle in clinical treatment. Among many pathogenic factors, the changes of vasoactive substances, participation of inflammatory mediators as well as OFR (oxygen free radical), endotoxin, etc. may play important roles in its progression.
authors: Department of General Surgery, Hangzhou First People's Hospital, Hangzhou 310006, China. zxp99688@vip.163.com
authors: Xi-ping
authors: XP
authors: Zhang
authors: Lei
authors: L
authors: Wang
authors: Jie
authors: J
authors: Zhang
mesh_terms: D000208:Acute Disease; D018450:Disease Progression; D004731:Endotoxins / Q000378:metabolism; D048550:Hepatic Insufficiency / Q000209:etiology / Q000503:physiopathology; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism; D009102:Multiple Organ Failure / Q000209:etiology; D010195:Pancreatitis / Q000150:complications / Q000378:metabolism / Q000503:physiopathology; D019283:Pancreatitis, Acute Necrotizing / Q000150:complications / Q000378:metabolism / Q000503:physiopathology; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D004731:Endotoxins; D018836:Inflammation Mediators; D017382:Reactive Oxygen Species