Comparison of the solubility and dissolution rate between gliclazide solid complex and its nanospheres.
The solid complex of gliclazide and beta-cyclodextrin was prepared by neutralization method and the precipitation solvent evaporation method was used to prepare gliclazide nanospheres. Fourier-transform infrared spectroscopy and differential scanning calorimetry were used to examine whether gliclazide solid complex and gliclazide nanospheres were successfully formed in this study. The dissolution rate of gliclazide from its nanospheres was faster than its solid complex and pure drug. The morphology of particles for nanospheres showed no crystal character of gliclazide. In summary, the results indicate that nanotechnology provides better effects in solubility and dissolution rate of gliclazide than neutralization method.
Lo
Yung-Kuang
YK
Graduate Institute of Pharmaceutical Sciences, Kaohsiung Medical University, San Min District, Kaohsiung City, Taiwan, ROC.
Chen
Chiu-Ju
CJ
Tsai
Tong-Rong
TR
Cham
Thau-Ming
TM
D002626:Chemistry, Pharmaceutical / Q000379:methods*; D005907:Gliclazide / Q000737:chemistry*; D007004:Hypoglycemic Agents / Q000737:chemistry*; D043942:Nanotubes / Q000737:chemistry*; D010316:Particle Size; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D047392:beta-Cyclodextrins / Q000737:chemistry*
D007004:Hypoglycemic Agents; D047392:beta-Cyclodextrins; D005907:Gliclazide; C031215:betadex