Isolated hepatitis B core antibody is associated with HIV and ongoing but not resolved hepatitis C virus infection in a cohort of US women.
To characterize predictors of isolated hepatitis B core antibody (anti-HBc) among human immunodeficiency virus (HIV)-infected and HIV-uninfected women, we compared 702 women with anti-HBc and hepatitis B surface antibody (anti-HBs) with 490 women with isolated anti-HBc (1.8% of whom had detectable hepatitis B virus [HBV] DNA). Factors independently associated with isolated anti-HBc without viremia were detectable hepatitis C virus (HCV) RNA, HIV positivity, history of injection drug use, >10 lifetime sex partners, and HIV RNA level >100,000 copies/mL. Anti-HBs levels were lower among anti-HCV-positive women. Isolated anti-HBc was rarely explained by occult HBV in this cohort but may be explained by the influence of viral coinfections on anti-HBs level or durability.
French
Audrey L
AL
CORE Center/Stroger (Cook County) Hospital, Rush Medical College, Chicago, IL 60612, USA. Audrey_French@rush.edu
Operskalski
Eva
E
Peters
Marion
M
Strickler
Howard D
HD
Tien
Phyllis C
PC
Sharp
Gerald B
GB
Glesby
Marshall J
MJ
Young
Mary
M
Augenbraun
Michael
M
Seaberg
Eric
E
Kovacs
Andrea
A
D000328:Adult; D015331:Cohort Studies; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000453:epidemiology; D016174:Hepacivirus / Q000302:isolation & purification; D006510:Hepatitis B Antibodies / Q000097:blood*; D006512:Hepatitis B Core Antigens / Q000032:analysis* / Q000276:immunology*; D006526:Hepatitis C / Q000150:complications* / Q000453:epidemiology; D006801:Humans; D015995:Prevalence; D011446:Prospective Studies; D014481:United States / Q000453:epidemiology; D019562:Viral Load
D006510:Hepatitis B Antibodies; D006512:Hepatitis B Core Antigens