title: Effect of parathyroidectomy on quality of life and neuropsychological symptoms in primary hyperparathyroidism.
abstract: Neuropsychological symptoms are found in a certain number of patients with primary hyperparathyroidism (PHPT). Preoperative and postoperative quality of life, anxiety, and depression are measured to analyze the impact of parathyroidectomy on these symptoms. In this prospective study, 66 patients underwent parathyroidectomy for PHPT and were evaluated pre- and postoperatively with two validated psychometric instruments (HADS, PHQ-9). Health-related quality of life was measured with a 12-item short-form health survey (SF-12). Preoperatively, the median physical component score (SF-12) of 43.0 and mental component score of 43.5 were lower than those of the general population (52.8 and 54.2 points, respectively). One year postoperatively the mental component score increased to 48.6 (p = 0.011), whereas the physical functioning scale scored 45.3 and therefore did not change significantly (p = 0.585). Preoperatively, symptoms of depression were found in 23.4% of the patients, and 15.6% of the patients displayed symptoms of anxiety (HADS). The prevalence of depression was significantly higher in patients with preoperative serum calcium levels > 11.2 mg/dl (2.8 mmol/L) (p = 0.015). Twelve months postoperatively, the overall proportion of patients with anxiety and depression decreased to 7.8% and 15.7%, respectively (p = NS). The severity of depression as measured with the PHQ-9 declined postoperatively as well. In this study, preoperative neuropsychological symptoms were related to the serum calcium levels. Postoperative health-related quality of life improved significantly. Among patients with preoperative symptoms of depression and anxiety, both symptoms were alleviated significantly at the 12-month follow-up. Therefore, surgery for PHPT seems to be effective in reducing neuropsychological morbidity associated with PHPT.
authors: Department of Surgery, University of Heidelberg, Heidelberg, Germany. weber@weberdigital.com
authors: Theresia
authors: T
authors: Weber
authors: Monika
authors: M
authors: Keller
authors: Isabella
authors: I
authors: Hense
authors: Alexander
authors: A
authors: Pietsch
authors: Ulf
authors: U
authors: Hinz
authors: Tobias
authors: T
authors: Schilling
authors: Peter
authors: P
authors: Nawroth
authors: Ernst
authors: E
authors: Klar
authors: Markus W
authors: MW
authors: Büchler
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001007:Anxiety / Q000097:blood / Q000175:diagnosis / Q000523:psychology*; D002118:Calcium / Q000097:blood; D003072:Cognition Disorders / Q000097:blood / Q000175:diagnosis / Q000523:psychology*; D003863:Depression / Q000097:blood / Q000175:diagnosis / Q000523:psychology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D049950:Hyperparathyroidism, Primary / Q000097:blood / Q000523:psychology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests / Q000706:statistics & numerical data; D010281:Parathyroid Hormone / Q000097:blood; D016105:Parathyroidectomy / Q000523:psychology*; D010555:Personality Inventory / Q000706:statistics & numerical data; D011183:Postoperative Complications / Q000097:blood / Q000175:diagnosis / Q000523:psychology*; D011446:Prospective Studies; D011594:Psychometrics; D011788:Quality of Life / Q000523:psychology*
chemical_list: D010281:Parathyroid Hormone; D002118:Calcium