Anticancer activity of limonoid from Khaya senegalensis.
Two limonoids were isolated from the methanol extract of Khaya senegalensis (Meliaceae), and their structures were identified as 3alpha,7alpha-dideacetylkhivorin (1) and 1-O-acetylkhayanolide B (2) on the basis of MS and NMR spectral data. Complete assignments of (1)H and (13)C chemical shifts for compounds 1 and 2 were achieved by means of 1D and 2D NMR including DEPT, (1)H-(1)H COSY, HMQC, HMBC experiments. Compound 1 showed significant growth inhibitory activities against MCF-7, SiHa and Caco-2 cells with IC(50) values in the range of 0.07-0.14 microm (35-69 ppm) while compound 2 did not.
Zhang
Huaping
H
Department of Food Science and Human Nutrition, Clemson University, Clemson, SC 29634, USA.
Wang
Xi
X
Chen
Feng
F
Androulakis
Xiao M
XM
Wargovich
Michael J
MJ
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000188:drug therapy / Q000473:pathology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D003110:Colonic Neoplasms / Q000188:drug therapy / Q000473:pathology; D005260:Female; D006801:Humans; D020128:Inhibitory Concentration 50; D036701:Limonins / Q000737:chemistry / Q000494:pharmacology*; D029582:Meliaceae / Q000737:chemistry*; D015394:Molecular Structure; D008517:Phytotherapy; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy / Q000473:pathology
D000972:Antineoplastic Agents, Phytogenic; D036701:Limonins