title: Diabetes and risk of non-Hodgkin lymphoma: a case-control study.
abstract: OBJECTIVE
  We investigated the relation between diabetes and the risk of non-Hodgkin lymphoma, as epidemiological results are controversial and diabetes has been related to the risk of several neoplasms.
  
  
  METHODS
  We analyzed the combined dataset of two Italian case-control studies conducted in 1985-1997 and 1999-2002. Cases were 671 patients, aged <85 years, with incident, histologically confirmed non-Hodgkin lymphoma, and controls were 1799 patients admitted to hospitals for acute non-neoplastic conditions. Odds ratios were estimated using unconditional multiple logistic regression models including terms for age, center, sex, residence and educational level.
  
  
  RESULTS
  No material association between diabetes and non-Hodgkin lymphoma risk was observed, with an odds ratio of 1.12 (95% confidence intervals, 0.70-1.77). No association was found in relation to age at first diagnosis of diabetes, years since diagnosis, or in younger and older subjects at diagnosis of non-Hodgkin lymphoma.
  
  
  CONCLUSIONS
  The results of the study allow to exclude a strong association between diabetes and non-Hodgkin lymphoma, although the small number of cases with diabetes leaves open the possibility of a moderate direct relation.
authors: Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.
authors: Lorenza
authors: L
authors: Scotti
authors: Alessandra
authors: A
authors: Tavani
authors: Cristina
authors: C
authors: Bosetti
authors: Luigino Dal
authors: LD
authors: Maso
authors: Renato
authors: R
authors: Talamini
authors: Maurizio
authors: M
authors: Montella
authors: Silvia
authors: S
authors: Franceschi
authors: Carlo
authors: C
authors: La Vecchia
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D003920:Diabetes Mellitus / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000150:complications*; D008297:Male; D008875:Middle Aged