[Kaposi's sarcoma-associated herpesvirus and mechanisms of oncogenesis].
Kaposi's sarcoma-associated herpesvirus (KSHV, also known as human herpesvirus 8), is well known to be responsible for Kaposi's sarcoma, the most common AIDS-related cancer. KSHV is also associated with the B cell malignancies primary effusion lymphoma and multicentric Castleman's disease. Cellular signaling pathways regulate the proliferation and differentiation during normal development and a small number of signaling pathways are involved in tumors. KSHV utilize those pathways, such as pRb-E2F, Wnt and Notch pathways, to promote driving of cell cycle and to regulate their own life-cycles (i.e., latency and lytic cycle). This review focuses on signaling pathways which KSHV gene products manipulate and discusses their contributions to tomorigenesis and regulation of viral life-cycles.
Fujimuro
Masahiro
M
Department of Biochemistry, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan. fuji2@pharm.hokudai.ac.jp
D000818:Animals; D002453:Cell Cycle; D050684:E2F Transcription Factors / Q000502:physiology; D019288:Herpesvirus 8, Human / Q000235:genetics / Q000254:growth & development / Q000472:pathogenicity; D006801:Humans; D008018:Life Cycle Stages; D018716:Molecular Mimicry; D051880:Receptors, Notch / Q000502:physiology; D012514:Sarcoma, Kaposi / Q000821:virology*; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology; D014764:Viral Proteins / Q000502:physiology; D051153:Wnt Proteins / Q000502:physiology
D050684:E2F Transcription Factors; D051880:Receptors, Notch; D014764:Viral Proteins; D051153:Wnt Proteins