Hepatoid carcinoma colliding with a liposarcoma of the left colon serosa presenting as an abdominal mass.
BACKGROUND
Hepatoid adenocarcinoma (HAC) is a peculiar type of extrahepatic adenocarcinoma generally characterized by adenocarcinomatous and hepatocellular carcinoma (HCC)-like foci. Stomach is the most frequent site where hepatoid adenocarcinoma occurs, although it has been described in many other organs. On the other side, liposarcoma is a rare, malignant tumor that develops from fat cells.


METHODS
We describe here a case of hepatoid carcinoma in collision with a liposarcoma of the left colon serosa in a 71-year-old man. It presented as an abdominal mass involving several organs, falsely mimicking metastatic colonic adenocarcinoma. Recognition of this entity was evident on microscopic evaluation following surgery. The patient had an objective response following liposomal antracycline chemotherapy, with a 3-year overall survival.


CONCLUSIONS
To our knowledge, this is the first case of a hepatoid tumor colliding with a liposarcoma of the left colon serosa reported to date.
Orditura
Michele
M
Cattedra di Oncologia Medica, Seconda Università degli Studi di Napoli Ospedale Da Procida, Salerno, Naples, Italy. michele.orditura@unina2.it
Lieto
Eva
E
Ferraraccio
Francesca
F
De Cataldis
Giuseppe
G
Troiani
Teresa
T
Castellano
Paolo
P
Catalano
Giuseppe
G
Ciardiello
Fortunato
F
Galizia
Gennaro
G
De Vita
Ferdinando
F
D000008:Abdominal Neoplasms / Q000473:pathology*; D000230:Adenocarcinoma / Q000473:pathology*; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000473:pathology*; D003110:Colonic Neoplasms / Q000473:pathology*; D006801:Humans; D008080:Liposarcoma / Q000473:pathology*; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000473:pathology*