The silent defense: micro-RNA directed defense against HIV-1 replication.
MicroRNAs play critical role in regulating gene expression. MicroRNA profile of particular cell type bears the signature of cell type specific gene expression. Given that viral pathogens replicate by evading host defenses, research is now focused on the miRNA-regulated genes that critically regulate HIV-1 propagation in human host cells.
Kumar
Ajit
A
Department of Biochemistry & Molecular Biology, George Washington University, Washington, DC, USA. akumar@gwu.edu
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology*; D005786:Gene Expression Regulation; D015497:HIV-1 / Q000235:genetics / Q000502:physiology*; D006801:Humans; D007113:Immunity, Innate; D035683:MicroRNAs / Q000502:physiology*; D012367:RNA, Viral / Q000502:physiology; D014779:Virus Replication
D035683:MicroRNAs; D012367:RNA, Viral