title: A multicenter study of BRD2 as a risk factor for juvenile myoclonic epilepsy.
abstract: OBJECTIVE
  Although complex idiopathic generalized epilepsies (IGEs) are recognized to have a significant genetic component, as yet there are no known common susceptibility variants. It has recently been suggested that variation in the BRD2 gene confers increased risk of juvenile myoclonic epilepsy (JME), which accounts for around a quarter of all IGE. Here we examine the association between the candidate causal SNP (the promoter variant rs3918149) and JME in five independent cohorts comprising in total 531 JME cases and 1,390 healthy controls.
  
  
  METHODS
  The strongest candidate causal variant from the original report (rs3918149) was genotyped across all five cohorts. In an effort to identify novel candidate causal polymorphisms, previously unscreened regions of UTR were resequenced.
  
  
  RESULTS
  We observed a significant effect in a small sample recruited in Britain (genotype p = 0.001, allele p = 0.001), a borderline significant effect in a sample recruited in Ireland and no association in larger samples of German, Australian, and Indian populations. There was no association with other common forms of epilepsy or any other clear candidate casual variants in or near the BRD2 region.
  
  
  CONCLUSIONS
  The replication of an effect in the British cohort and suggestive evidence from that recruited in Ireland but lack of replication from the larger German, Australian, and Indian cohorts is surprising and difficult to explain. Further replication in carefully matched populations is required. Results presented here do not, however, support a strong effect for susceptibility to JME across populations of European descent.
authors: The Department of Clinical Neurological Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland.
authors: Gianpiero L
authors: GL
authors: Cavalleri
authors: Nicole M
authors: NM
authors: Walley
authors: Nicole
authors: N
authors: Soranzo
authors: John
authors: J
authors: Mulley
authors: Colin P
authors: CP
authors: Doherty
authors: Ashish
authors: A
authors: Kapoor
authors: Chantal
authors: C
authors: Depondt
authors: John M
authors: JM
authors: Lynch
authors: Ingrid E
authors: IE
authors: Scheffer
authors: Armin
authors: A
authors: Heils
authors: Anne
authors: A
authors: Gehrmann
authors: Peter
authors: P
authors: Kinirons
authors: Sonia
authors: S
authors: Gandhi
authors: Parthasarathy
authors: P
authors: Satishchandra
authors: Nicholas W
authors: NW
authors: Wood
authors: Anuranjan
authors: A
authors: Anand
authors: Thomas
authors: T
authors: Sander
authors: Samuel F
authors: SF
authors: Berkovic
authors: Norman
authors: N
authors: Delanty
authors: David B
authors: DB
authors: Goldstein
authors: Sanjay M
authors: SM
authors: Sisodiya
mesh_terms: D016022:Case-Control Studies; D015331:Cohort Studies; D018740:Genetic Heterogeneity; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D005828:Genetics, Population; D005838:Genotype; D006801:Humans; D020190:Myoclonic Epilepsy, Juvenile / Q000453:epidemiology / Q000235:genetics*; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D011401:Promoter Regions, Genetic / Q000235:genetics; D017346:Protein Serine-Threonine Kinases / Q000235:genetics*; D012307:Risk Factors; D014157:Transcription Factors; D006113:United Kingdom / Q000453:epidemiology; D044465:White People / Q000235:genetics / Q000706:statistics & numerical data; D000092468:Bromodomain Containing Proteins
chemical_list: D017346:Protein Serine-Threonine Kinases; D014157:Transcription Factors; C098415:BRD2 protein, human; D000092468:Bromodomain Containing Proteins