Role of genetic factors and inflammation in age-related macular degeneration.
Complement factor H (CFH) has been implicated in the predisposition to advanced forms of age-related macular degeneration (AMD). The purpose of this review is to highlight recent discoveries implicating single nucleotide polymorphisms on 1q32, 6p21, and 10q26 in the risk for development of AMD. In addition, the central role of CFH in the complement cascade and its role in the inflammatory hypothesis for AMD are reviewed.
Moshfeghi
Darius M
DM
Department of Ophthalmology, Stanford University School of Medicine, Stanford, California, USA. dariusm@stanford.edu
Blumenkranz
Mark S
MS
D002878:Chromosomes, Human, Pair 1 / Q000235:genetics*; D002879:Chromosomes, Human, Pair 10 / Q000235:genetics*; D002896:Chromosomes, Human, Pair 6 / Q000235:genetics*; D017242:Complement Factor H / Q000235:genetics; D006801:Humans; D007249:Inflammation / Q000235:genetics*; D008268:Macular Degeneration / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
C493495:CFH protein, human; D017242:Complement Factor H