title: A mild and efficient synthesis of 4-quinolones and quinolone heterocycles.
abstract: The cycloacylation of aniline derivatives to 4-quinolones in the presence of Eaton's reagent is described. This high-yielding methodology is applicable to a wide variety of functionalized anilines and requires milder conditions than those traditionally employed. This cyclization protocol is used to prepare a host of heterocycles and bis-quinolones and is characterized by relatively low reaction temperature and ease of product isolation.
authors: Department of Process Research, Merck Research Laboratories, P.O. Box 2000, Rahway, New Jersey 07065, USA. daniel_zewge@merck.com
authors: Daniel
authors: D
authors: Zewge
authors: Cheng-Yi
authors: CY
authors: Chen
authors: Curtis
authors: C
authors: Deer
authors: Peter G
authors: PG
authors: Dormer
authors: Dave L
authors: DL
authors: Hughes
mesh_terms: D002384:Catalysis; D003500:Cyclization; D006571:Heterocyclic Compounds / Q000138:chemical synthesis*; D015394:Molecular Structure; D015363:Quinolones / Q000138:chemical synthesis*
chemical_list: D006571:Heterocyclic Compounds; D015363:Quinolones