title: Elloxazinones A and B, New Aminophenoxazinones from Streptomyces griseus Acta 2871.
abstract: Two new aminophenoxazinone compounds with antitumor activity, elloxazinone A and B, were isolated from the culture filtrate of Streptomyces griseus Acta 2871. Their chemical structures were determined by mass spectrometry, NMR spectroscopy and X-ray analysis. Elloxazinones A and B showed a moderate inhibition of the proliferation of human cells from gastric adenocarcinoma in vitro but a strong inhibition of hepatocellular carcinoma cells whereas elloxazinone B strongly inhibited the proliferation of human breast carcinoma cells.
authors: Institut für Chemie, Technische Universität Berlin.
authors: Ellen
authors: E
authors: Graf
authors: Kathrin
authors: K
authors: Schneider
authors: Graeme
authors: G
authors: Nicholson
authors: Markus
authors: M
authors: Ströbele
authors: Amanda L
authors: AL
authors: Jones
authors: Michael
authors: M
authors: Goodfellow
authors: Winfried
authors: W
authors: Beil
authors: Roderich D
authors: RD
authors: Süssmuth
authors: Hans-Peter
authors: HP
authors: Fiedler
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002453:Cell Cycle / Q000187:drug effects; D045744:Cell Line, Tumor; D005285:Fermentation; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D010078:Oxazines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013305:Streptomyces griseus / Q000145:classification / Q000378:metabolism*; D013329:Structure-Activity Relationship
chemical_list: D000903:Antibiotics, Antineoplastic; D010078:Oxazines; C521436:elloxazinone A; C521437:elloxazinone B