Solid type clear cell carcinoma of the pancreas: differential diagnosis of an unusual case and review of the literature.
Pancreatic neoplasms have been reliably classified on the basis of their histopathology and immunophenotype. In this study, we report on a pancreatic tumor whose phenotype and genotype could not be assigned to any known tumor entity. The tumor was observed in the pancreatic head of a 54-year-old woman. It was found to be a solid infiltrating carcinoma with abundant clear cells. Apart from cytokeratin, the tumor cells expressed vimentin, S100, and MUC-1. DNA microarray analysis revealed a transcription profile clearly differing from that of normal pancreatic tissue and pancreatic ductal adenocarcinoma. Despite metastatic behavior, the tumor displayed a more favorable course than conventional pancreatic ductal adenocarcinoma. We suggest that this tumor be called solid type clear cell carcinoma of the pancreas.
Loos
Martin
M
Department of General Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany.
Bergmann
Frank
F
Bauer
Andrea
A
Hoheisel
Jörg D
JD
Esposito
Irene
I
Kleeff
Jörg
J
Schirmacher
Peter
P
Büchler
Markus W
MW
Klöppel
Günter
G
Friess
Helmut
H
D018262:Adenocarcinoma, Clear Cell / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology / Q000556:secondary; D003937:Diagnosis, Differential; D005260:Female; D020869:Gene Expression Profiling; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000378:metabolism; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary; D046228:Microarray Analysis; D008875:Middle Aged; D018396:Mucin-1 / Q000378:metabolism; D020411:Oligonucleotide Array Sequence Analysis; D010190:Pancreatic Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D020133:Reverse Transcriptase Polymerase Chain Reaction; D009418:S100 Proteins / Q000378:metabolism; D036542:Tomography, Spiral Computed; D014746:Vimentin / Q000378:metabolism
C060192:MUC1 protein, human; D018396:Mucin-1; D009418:S100 Proteins; D014746:Vimentin; D007633:Keratins