title: Evolutionary origins of insulin resistance: a behavioral switch hypothesis.
abstract: BACKGROUND
  Insulin resistance, which can lead to a number of diseases including type 2 diabetes and coronary heart disease, is believed to have evolved as an adaptation to periodic starvation. The "thrifty gene" and "thrifty phenotype" hypotheses constitute the dominant paradigm for over four decades. With an increasing understanding of the diverse effects of impairment of the insulin signaling pathway, the existing hypotheses are proving inadequate.
  
  
  OBJECTIVE
  We propose a hypothesis that insulin resistance is a socio-ecological adaptation that mediates two phenotypic transitions, (i) a transition in reproductive strategy from "r" (large number of offspring with little investment in each) to "K" (smaller number of offspring with more investment in each) and (ii) a transition from "stronger to smarter" or "soldier to diplomat" i.e. from relatively more muscle dependent to brain dependent lifestyle. A common switch could have evolved for the two transitions since the appropriate environmental conditions for the two transitions are highly overlapping and interacting.
  
  
  METHODS
  Gestational insulin resistance diverts more energy through the placenta, resulting in increased investment per offspring. On the other hand, insulin resistance is associated with reduced ovulation. The insulin signaling pathway is also related to longevity. Insulin resistance diverts more nutrients to the brain as compared to muscle. Also, hyperinsulinemia has direct positive effects on cognitive functions of the brain. The hypothesis gets support from known patterns in human clinical data and recent research on the molecular interactions in the insulin signaling pathway. Further we state many predictions of the hypothesis that can be tested experimentally or epidemiologically.
  
  
  CONCLUSIONS
  The hypothesis can bring about a significant change in the line of treatment as well as public health policies for the control of metabolic syndrome.
authors: Anujeeva Biosciences Pvt. Ltd., Navi peth, Pune, India. milind_watve@yahoo.com
authors: Milind G
authors: MG
authors: Watve
authors: Chittaranjan S
authors: CS
authors: Yajnik
mesh_terms: D000222:Adaptation, Physiological / Q000235:genetics*; D000818:Animals; D005075:Biological Evolution; D006801:Humans; D007333:Insulin Resistance / Q000235:genetics / Q000502:physiology*; D024821:Metabolic Syndrome / Q000235:genetics / Q000503:physiopathology; D010641:Phenotype; D012098:Reproduction; D012641:Selection, Genetic; D015430:Weight Gain / Q000235:genetics