Increased peripheral lipid clearance in an animal model of amyotrophic lateral sclerosis.
Amyotrophic lateral sclerosis (ALS) is the most common adult motor neuron disease, causing motor neuron degeneration, muscle atrophy, paralysis, and death. Despite this degenerative process, a stable hypermetabolic state has been observed in a large subset of patients. Mice expressing a mutant form of Cu/Zn-superoxide dismutase (mSOD1 mice) constitute an animal model of ALS that, like patients, exhibits unexpectedly increased energy expenditure. Counterbalancing for this increase with a high-fat diet extends lifespan and prevents motor neuron loss. Here, we investigated whether lipid metabolism is defective in this animal model. Hepatic lipid metabolism was roughly normal, whereas gastrointestinal absorption of lipids as well as peripheral clearance of triglyceride-rich lipoproteins were markedly increased, leading to decreased postprandial lipidemia. This defect was corrected by the high-fat regimen that typically induces neuroprotection in these animals. Together, our findings show that energy metabolism in mSOD1 mice shifts toward an increase in the peripheral use of lipids. This metabolic shift probably accounts for the protective effect of dietary lipids in this model.
Fergani
Anissa
A
Institut National de la Santé et de la Recherche Médicale, U692, Laboratoire de Signalisations Moléculaires et Neurodégénérescence, Strasbourg, F-67085 France.
Oudart
Hugues
H
Gonzalez De Aguilar
Jose-Luis
JL
Fricker
Bastien
B
René
Frédérique
F
Hocquette
Jean-François
JF
Meininger
Vincent
V
Dupuis
Luc
L
Loeffler
Jean-Philippe
JP
D000690:Amyotrophic Lateral Sclerosis / Q000503:physiopathology*; D000818:Animals; D004734:Energy Metabolism; D005260:Female; D020869:Gene Expression Profiling; D007408:Intestinal Absorption; D008055:Lipids / Q000097:blood*; D008099:Liver / Q000378:metabolism; D051379:Mice; D008822:Mice, Transgenic; D018482:Muscle, Skeletal / Q000378:metabolism; D013482:Superoxide Dismutase / Q000235:genetics*; D000072105:Superoxide Dismutase-1; D014280:Triglycerides / Q000097:blood
D008055:Lipids; D014280:Triglycerides; C000606291:Sod1 protein, mouse; D013482:Superoxide Dismutase; D000072105:Superoxide Dismutase-1