CYP1B1 and predisposition to breast cancer in Poland.
BACKGROUND
The CYP1B1 gene is a polymorphic member of the P450 gene family and is considered to be a candidate gene for cancers of various types.


OBJECTIVE
We inquired whether four SNPs in the CYP1B1 gene, alone or in combination, might be associated with breast cancer risk in Poland.


METHODS
We genotyped 2017 cases of breast cancer and 876 controls, for four SNPs in the CYP1B1 gene. Genotype and haplotype frequencies were compared in cases and controls.


RESULTS
In combinations of the R48G, A119S and L432V SNPs, four of the eight CYP1B1 haplotypes were more common in controls than in cases and each of these appeared to have a significant protective effect. A large reduction in risk was observed for women who were homozygous for one of these four haplotypes (OR = 0.2; 95%; CI = 0.05-0.5; P = 0.001) compared to women who were homozygous for the most common haplotype. In contrast, women who were homozygous for the GTC haplotype were at increased risk (OR = 1.5; 95%; CI = 1.0-2.1; P = 0.03) compared to women with the most common haplotype.


CONCLUSIONS
The CYP1B1 gene appears to influence breast cancer susceptibility in Poland.
Matyjasik
Joanna
J
Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, Szczecin, Poland.
Cybulski
Cezary
C
Masojć
Bartlomiej
B
Jakubowska
Anna
A
Serrano-Fernandez
Pablo
P
Górski
Bohdan
B
Debniak
Tadeusz
T
Huzarski
Tomasz
T
Byrski
Tomasz
T
Gronwald
Jacek
J
Złowocka
Elzbieta
E
Narod
Steven Alexander
SA
Scott
Rodney
R
Lubinski
Jan
J
D001189:Aryl Hydrocarbon Hydroxylases; D001943:Breast Neoplasms / Q000201:enzymology / Q000235:genetics*; D065633:Cytochrome P-450 CYP1B1; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D011044:Poland; D020641:Polymorphism, Single Nucleotide
D003577:Cytochrome P-450 Enzyme System; D001189:Aryl Hydrocarbon Hydroxylases; C585496:CYP1B1 protein, human; D065633:Cytochrome P-450 CYP1B1