title: Compensatory change of interacting amino acids in the coevolution of transcriptional coactivator MBF1 and TATA-box-binding protein.
abstract: To elucidate the transcriptional regulation in eukaryotic genome network, it is important to understand coevolution of transcription factors, transcriptional coactivators, and TATA-box-binding protein (TBP). In this study, coevolution of transcriptional coactivator multiprotein-bridging factor 1 and its interacting target TBP was first evaluated experimentally by examining if compensatory amino acid changes took place at interacting sites of both proteins. The experiments were conducted by identifying interaction sites and comparing the amino acids at these sites among different organisms. Here, we provide evidence for compensatory changes of transcription coactivator and its interacting target, presenting the 1st report that transcription coactivator may have undergone coevolution with TBP.
authors: Center for Information Biology and DNA Data Bank of Japan, National Institute of Genetics, Mishima, Shizuoka, Japan.
authors: Qing-Xin
authors: QX
authors: Liu
authors: Naomi
authors: N
authors: Nakashima-Kamimura
authors: Kazuho
authors: K
authors: Ikeo
authors: Susumu
authors: S
authors: Hirose
authors: Takashi
authors: T
authors: Gojobori
mesh_terms: D000596:Amino Acids / Q000235:genetics*; D019143:Evolution, Molecular; D020125:Mutation, Missense; D011485:Protein Binding / Q000235:genetics; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics*; D016415:Sequence Alignment; D035181:TATA-Box Binding Protein / Q000235:genetics*; D015534:Trans-Activators / Q000235:genetics*; D014157:Transcription Factors
chemical_list: D000596:Amino Acids; C106951:MBF1 protein, S cerevisiae; D029701:Saccharomyces cerevisiae Proteins; D035181:TATA-Box Binding Protein; D015534:Trans-Activators; D014157:Transcription Factors