title: The Virtual International Stroke Trials Archive.
abstract: OBJECTIVE
  Stroke has global importance and it causes an increasing amount of human suffering and economic burden, but its management is far from optimal. The unsuccessful outcome of several research programs highlights the need for reliable data on which to plan future clinical trials. The Virtual International Stroke Trials Archive aims to aid the planning of clinical trials by collating and providing access to a rich resource of patient data to perform exploratory analyses.
  
  
  METHODS
  Data were contributed by the principal investigators of numerous trials from the past 16 years. These data have been centrally collated and are available for anonymized analysis and hypothesis testing.
  
  
  RESULTS
  Currently, the Virtual International Stroke Trials Archive contains 21 trials. There are data on >15,000 patients with both ischemic and hemorrhagic stroke. Ages range between 18 and 103 years, with a mean age of 69+/-12 years. Outcome measures include the Barthel Index, Scandinavian Stroke Scale, National Institutes of Health Stroke Scale, Orgogozo Scale, and modified Rankin Scale. Medical history and onset-to-treatment time are readily available, and computed tomography lesion data are available for selected trials.
  
  
  CONCLUSIONS
  This resource has the potential to influence clinical trial design and implementation through data analyses that inform planning.
authors: University Department of Medicine and Therapeutics, Gardiner Institute, Western Infirmary, Glasgow, UK.
authors: Myzoon
authors: M
authors: Ali
authors: Philip M W
authors: PM
authors: Bath
authors: John
authors: J
authors: Curram
authors: Stephen M
authors: SM
authors: Davis
authors: Hans-Christoph
authors: HC
authors: Diener
authors: Geoffrey A
authors: GA
authors: Donnan
authors: Marc
authors: M
authors: Fisher
authors: Barbara A
authors: BA
authors: Gregson
authors: James
authors: J
authors: Grotta
authors: Werner
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authors: Hacke
authors: Michael G
authors: MG
authors: Hennerici
authors: Marc
authors: M
authors: Hommel
authors: Markku
authors: M
authors: Kaste
authors: John R
authors: JR
authors: Marler
authors: Ralph L
authors: RL
authors: Sacco
authors: Philip
authors: P
authors: Teal
authors: Nils-Gunnar
authors: NG
authors: Wahlgren
authors: Steven
authors: S
authors: Warach
authors: Christopher J
authors: CJ
authors: Weir
authors: Kennedy R
authors: KR
authors: Lees
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001109:Archives; D005260:Female; D006801:Humans; D038622:Internationality; D008297:Male; D008875:Middle Aged; D016032:Randomized Controlled Trials as Topic; D020521:Stroke / Q000453:epidemiology* / Q000628:therapy