Differential effects of aging on activin A and its binding protein, follistatin, across the menopause transition.
To assess the involvement of ovarian-derived regulatory proteins in FSH modulation, we compared FSH, inhibin A, inhibin B, activin A, and follistatin (FS) in 79 women from the following five groups: young cycling, older cycling, perimenopause (PERI), spontaneous menopause (PM), and surgical menopause receiving estrogen (OVX+ET). Although inhibin B varied as expected by ovarian function, no group differences were observed in activin A, barring a tendency for an increase in PERI, while FS 288 was lower in the PERI, PM, and OVX+ET groups and negatively correlated with advancing age.
Reame
Nancy E
NE
School of Nursing, University of Michigan, Ann Arbor, Michigan, USA. nr2188@columbia.edu
Lukacs
Jane L
JL
Olton
Pamela
P
Ansbacher
Rudi
R
Padmanabhan
Vasantha
V
D028341:Activins / Q000502:physiology*; D000328:Adult; D000375:Aging / Q000502:physiology*; D003430:Cross-Sectional Studies; D005260:Female; D005640:Follicle Stimulating Hormone / Q000378:metabolism; D038681:Follistatin / Q000502:physiology*; D006801:Humans; D007265:Inhibins / Q000502:physiology; D008593:Menopause / Q000502:physiology*; D008875:Middle Aged; D010052:Ovariectomy
C503233:FST protein, human; D038681:Follistatin; C422405:activin A; C422362:inhibin A; C422364:inhibin B; D028341:Activins; D007265:Inhibins; D005640:Follicle Stimulating Hormone