[Effects of alpha-tocopherol on partial functions of the ischemic kidney].
The experiments on 45 rats and 20 rabbits were made to investigate antiischemic efficacy of alpha-tocopherol in respect of various partial functions of the kidneys compared to its antioxidant activity. It is demonstrated that administration of alpha-tocopherol prior to 30-min heat ischemia arrests activation of membrane lipid peroxidation (LPO) in the tissue of ischemic kidney both in rabbits and rats. Rabbit filtration renal function 1 hour after circulation recovery improved insignificantly, 24 hours after the recovery no difference with the control was registered, while secretory and reabsorption functions of the renal tubules under conditions of pretreatment with alpha-tocopherol significantly improved both in rabbits and rats both 1 hour and 24 hours after ischemia. Estimation of Ca-ATP activity of a microsomal fraction of the cortical substance of the ischemic kidneys has detected alpha-tocopherol induced suppression of LPO in sub-cellular membrane and high activity of this enzyme. Mechanisms of different protective action of alpha-tocopherol on renal glomeruli and tubules are discussed.
Kirpatovskiĭ
V I
VI
Golod
E A
EA
Nadtochiĭ
O N
ON
Obukhova
T V
TV
D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000627:therapeutic use*; D002118:Calcium / Q000652:urine; D003404:Creatinine / Q000097:blood / Q000652:urine; D004195:Disease Models, Animal; D005919:Glomerular Filtration Rate / Q000187:drug effects*; D007457:Iodine Radioisotopes; D007465:Iodohippuric Acid; D007511:Ischemia / Q000188:drug therapy* / Q000503:physiopathology / Q000652:urine; D007668:Kidney / Q000098:blood supply* / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology; D007671:Kidney Concentrating Ability / Q000187:drug effects*; D008054:Lipid Peroxides / Q000378:metabolism; D011817:Rabbits; D011866:Radioisotope Renography; D051381:Rats; D012964:Sodium / Q000652:urine; D024502:alpha-Tocopherol / Q000008:administration & dosage / Q000627:therapeutic use*
D000975:Antioxidants; D007457:Iodine Radioisotopes; D008054:Lipid Peroxides; D007465:Iodohippuric Acid; D012964:Sodium; D003404:Creatinine; D024502:alpha-Tocopherol; D002118:Calcium