title: Computerized measurement of facial expression of emotions in schizophrenia.
abstract: Deficits in the ability to express emotions characterize several neuropsychiatric disorders and are a hallmark of schizophrenia, and there is need for a method of quantifying expression, which is currently done by clinical ratings. This paper presents the development and validation of a computational framework for quantifying emotional expression differences between patients with schizophrenia and healthy controls. Each face is modeled as a combination of elastic regions, and expression changes are modeled as a deformation between a neutral face and an expressive face. Functions of these deformations, known as the regional volumetric difference (RVD) functions, form distinctive quantitative profiles of expressions. Employing pattern classification techniques, we have designed expression classifiers for the four universal emotions of happiness, sadness, anger and fear by training on RVD functions of expression changes. The classifiers were cross-validated and then applied to facial expression images of patients with schizophrenia and healthy controls. The classification score for each image reflects the extent to which the expressed emotion matches the intended emotion. Group-wise statistical analysis revealed this score to be significantly different between healthy controls and patients, especially in the case of anger. This score correlated with clinical severity of flat affect. These results encourage the use of such deformation based expression quantification measures for research in clinical applications that require the automated measurement of facial affect.
authors: Section of Biomedical Image Analysis, Department of Radiology, University of Pennsylvania, 3600 Market, Suite 380, Philadelphia, PA 19104, United States. calvino.ece05@gtalumni.org
authors: Christopher
authors: C
authors: Alvino
authors: Christian
authors: C
authors: Kohler
authors: Frederick
authors: F
authors: Barrett
authors: Raquel E
authors: RE
authors: Gur
authors: Ruben C
authors: RC
authors: Gur
authors: Ragini
authors: R
authors: Verma
mesh_terms: D000328:Adult; D004644:Emotions / Q000145:classification* / Q000502:physiology*; D005145:Face / Q000033:anatomy & histology / Q000502:physiology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008297:Male; D009484:Neuropsychology / Q000379:methods*; D015588:Observer Variation; D012016:Reference Values; D012559:Schizophrenia / Q000175:diagnosis* / Q000503:physiopathology; D012565:Schizophrenic Psychology; D012984:Software; D012986:Software Validation