title: Increased expression of platelet-derived growth factor C messenger ribonucleic acid in uterine leiomyomata.
abstract: This study was intended to investigate the possible roles of the platelet-derived growth factor (PDGF) gene family's involvement in the pathogenesis of uterine leiomyomata. We examined the differential gene expressions of PDGF-A, -B, -C, -D, PDGF receptor alpha (PDGFR-alpha), and receptor beta (PDGFR-beta) between uterine leiomyomata and the adjacent normal myometrium. Expression of PDGF-C in leiomyomata was significantly higher (approximately 2.4-fold) than in the adjacent normal myometrium, whereas there were no significant differences in the expressions of PDGF-A, -B, -D, PDGFR-alpha, or PDGFR-beta between leiomyomata and the adjacent myometrial tissues.
authors.affiliation: Department of Obstetrics and Gynecology, Mackay Memorial Hospital, Taipei, Taiwan.
authors.forename: Yuh-Ming
authors.initials: YM
authors.lastname: Hwu
authors.forename: Sheng-Hsiang
authors.initials: SH
authors.lastname: Li
authors.forename: Robert Kuo-kuang
authors.initials: RK
authors.lastname: Lee
authors.forename: Yu-Hui
authors.initials: YH
authors.lastname: Tsai
authors.forename: Tien-Shun
authors.initials: TS
authors.lastname: Yeh
authors.forename: Shyr-Yeu
authors.initials: SY
authors.lastname: Lin
mesh_terms: D000328:Adult; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D018231:Leiomyomatosis / Q000235:genetics* / Q000378:metabolism; D008222:Lymphokines / Q000235:genetics*; D016555:Matched-Pair Analysis; D008875:Middle Aged; D005810:Multigene Family; D009215:Myometrium / Q000378:metabolism; D010982:Platelet-Derived Growth Factor / Q000235:genetics*; D012333:RNA, Messenger / Q000378:metabolism; D017479:Receptors, Platelet-Derived Growth Factor / Q000235:genetics / Q000378:metabolism; D015854:Up-Regulation; D014594:Uterine Neoplasms / Q000235:genetics* / Q000378:metabolism
chemical_list: D008222:Lymphokines; D010982:Platelet-Derived Growth Factor; D012333:RNA, Messenger; C411423:platelet-derived growth factor C; D017479:Receptors, Platelet-Derived Growth Factor