One-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones using chloroacetic acid as catalyst.
A simple and effective synthesis of 3,4-dihydropyrimidin-2(1H)-one derivatives from aldehydes, 1,3-dicarbonyl compounds and urea or thiourea using chloroacetic acid as catalyst under solvent-free conditions is described. Compared with the classical Biginelli reaction conditions, this new method has the advantage of good to excellent yields and short reaction time.
Yu
Yang
Y
Department of Chemistry, Liaoning University of Petroleum and Chemical Technology, Fushun, Liaoning 113001, PR China.
Liu
Di
D
Liu
Chunsheng
C
Luo
Genxiang
G
D000085:Acetates / Q000737:chemistry*; D000447:Aldehydes / Q000737:chemistry; D002121:Calcium Channel Blockers / Q000138:chemical synthesis* / Q000494:pharmacology; D002384:Catalysis; D008956:Models, Chemical; D013890:Thiourea / Q000737:chemistry; D014508:Urea / Q000737:chemistry
D000085:Acetates; D000447:Aldehydes; D002121:Calcium Channel Blockers; C006972:chloroacetic acid; D014508:Urea; D013890:Thiourea