Can irradiated tumors take NO for an answer?
In a recent issue of Molecular Cell, Li et al. (2007) reported that ionizing radiation stabilizes hypoxia-inducible factor 1alpha (HIF-1alpha) in normoxic tumor tissues through S-nitrosylation by nitric oxide (NO) generated from neighboring activated macrophages.
Johnson
Randall S
RS
Molecular Biology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA.
Huang
L Eric
LE
D000818:Animals; D015870:Gene Expression / Q000528:radiation effects; D006801:Humans; D000860:Hypoxia / Q000235:genetics / Q000378:metabolism; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000235:genetics / Q000378:metabolism; D008264:Macrophages / Q000378:metabolism; D051379:Mice; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000532:radiotherapy*; D009569:Nitric Oxide / Q000378:metabolism*; D052247:Nitric Oxide Synthase Type II / Q000378:metabolism
D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D009569:Nitric Oxide; D052247:Nitric Oxide Synthase Type II