title: Enantioselectively organocatalytic Michael addition of ketones to alkylidene malonates.
abstract: An organocatalytic asymmetric Michael addition of ketones to alkylidene malonates has been developed. In the presence of 20 mol % of urea 1a or N-(pyrrolidin-2-ylmethyl)trifluoromethanesulfonamide 1j, the reactions of ketones with alkylidene malonates afford the desired Michael adducts in moderate to good yields with good to high enantioselectivities under mild conditions.
authors.affiliation: State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, People's Republic of China.
authors.forename: Chun-Li
authors.initials: CL
authors.lastname: Cao
authors.forename: Xiu-Li
authors.initials: XL
authors.lastname: Sun
authors.forename: Jiao-Long
authors.initials: JL
authors.lastname: Zhou
authors.forename: Yong
authors.initials: Y
authors.lastname: Tang