title: An efficient route for the synthesis of a new class of pyrido[2,3-d]pyrimidine derivatives.
abstract: A new reaction of 4-arylidene-3-methylisoxazol-5(4H)-one or 4-arylidene-2-phenyloxazol-5(4H)-one with 2,6-diaminopyrimidin-4(3H)-one is described and a number of new pyrido[2,3-d]pyrimidine-4,7-dione derivatives are synthesized. This protocol has the advantages of good yields, broad substrate scope and simple work-up.
authors.affiliation: Department of Chemistry, Xuzhou Normal University, Key Laboratory of Biotechnology for Medicinal Plant Xuzhou, Jiangsu, 211116, P.R. China. laotu@xznu.edu.cn
authors.forename: Shujiang
authors.initials: S
authors.lastname: Tu
authors.forename: Junyong
authors.initials: J
authors.lastname: Zhang
authors.forename: Runhong
authors.initials: R
authors.lastname: Jia
authors.forename: Bo
authors.initials: B
authors.lastname: Jiang
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Hong
authors.initials: H
authors.lastname: Jiang
mesh_terms: D008872:Microwaves; D008958:Models, Molecular; D011728:Pyridones / Q000138:chemical synthesis* / Q000737:chemistry; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry; D011744:Pyrimidinones / Q000138:chemical synthesis* / Q000737:chemistry; D012997:Solvents; D013696:Temperature
chemical_list: D011728:Pyridones; D011743:Pyrimidines; D011744:Pyrimidinones; D012997:Solvents; C030986:pyrimidine