title: Calcium metabolism of pregnant rats fed a vitamin D-depleted diet.
abstract: The effects of vitamin D (VD) deficiency on calcium (Ca) metabolism during pregnancy were evaluated in rats fed VD-repleted (VD-repleted rats) and VD-depleted (VD-depleted rats) diets. In the VD-depleted rats, the plasma concentrations of 1,25-dihydroxyvitamin D and Ca decreased severely, whereas the parathyroid hormone concentrations increased. The Ca contents of the feces of the VD-depleted rats were higher than those of the VD-repleted rats. The fetal Ca contents of the VD-repleted and VD-depleted rats increased continuously, but that of the VD-depleted rats was lower. These data reveal that VD deficiency during pregnancy induces severe hypocalcemia due to reduced intestinal absorption of Ca and elevated fetal demand for Ca.
authors.affiliation: Department of Clinical Veterinary Medicine, Faculty of Agriculture, Iwate University, Morioka, Japan.
authors.forename: Norio
authors.initials: N
authors.lastname: Yamagishi
authors.forename: Hiromi
authors.initials: H
authors.lastname: Sassa
authors.forename: Reeko
authors.initials: R
authors.lastname: Sato
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Taniguchi
authors.forename: Norimoto
authors.initials: N
authors.lastname: Okura
authors.forename: Shigeru
authors.initials: S
authors.lastname: Sato
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Naito
mesh_terms: D000818:Animals; D002118:Calcium / Q000097:blood / Q000378:metabolism* / Q000652:urine; D005243:Feces / Q000737:chemistry; D005260:Female; D005269:Femur / Q000737:chemistry; D047109:Fetal Development / Q000502:physiology*; D010281:Parathyroid Hormone / Q000097:blood; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014807:Vitamin D / Q000031:analogs & derivatives / Q000097:blood; D014808:Vitamin D Deficiency / Q000378:metabolism*
chemical_list: D010281:Parathyroid Hormone; D014807:Vitamin D; C097949:1,25-dihydroxyvitamin D; D002118:Calcium