title: [Genetic status of a AB chimeric blood group family].
abstract: In order to study the genetic status of a rare chimeric family, some samples of A(3)B(3) family were identified by sequencing of ABO gene; flow-rSSO and PCR-SSP were used to detect loci of HLA-A, B, DRB1 genes, and multiplex amplifying with fluorescence-dye were performed for 16 short tandem repeat (STR) loci. The results indicated that two individuals from A(3)B(3) family contained more than two alleles at ABO gene, HLA-B, DRB1 and some STR loci. In conclusion, analysis of chimeric blood group by using genotyping techniques clearly demonstrating genetic status of this rare chimeric blood group promotes further elucidation of the existing state of specific genetic status.
authors.affiliation: Shenzhen Institute of Transfusion Medicine, Shenzhen Blood Center, Shenzhen 518035, China.
authors.forename: Bao-Cheng
authors.initials: BC
authors.lastname: Yang
authors.forename: Qiong
authors.initials: Q
authors.lastname: Yu
authors.forename: Yu-Qing
authors.initials: YQ
authors.lastname: Su
authors.forename: Dan
authors.initials: D
authors.lastname: Zhou
authors.forename: Shi-Zheng
authors.initials: SZ
authors.lastname: Jin
authors.forename: Qian
authors.initials: Q
authors.lastname: Li
authors.forename: Yan-Lian
authors.initials: YL
authors.lastname: Liang
authors.forename: Zhi-Hui
authors.initials: ZH
authors.lastname: Deng
mesh_terms: D000017:ABO Blood-Group System / Q000235:genetics* / Q000276:immunology; D000328:Adult; D046528:Chimerism; D005260:Female; D005838:Genotype; D015234:HLA-A Antigens / Q000235:genetics; D015235:HLA-B Antigens / Q000235:genetics; D006684:HLA-DR Antigens / Q000235:genetics; D059811:HLA-DRB1 Chains; D006801:Humans; D008297:Male; D010375:Pedigree; D011110:Polymorphism, Genetic; D020080:Tandem Repeat Sequences / Q000235:genetics
chemical_list: D000017:ABO Blood-Group System; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains