title: Two cases of primary biliary cirrhosis complicated by acute leukemia.
abstract: Case 1 was a 43-year-old woman, who was diagnosed as having PBC. After one month, she was hospitalized owing to sudden temporary unconsciousness. She was diagnosed as having acute lymphoid leukemia (ALL) by bone marrow examination. Chemotherapy was done, but she died after 6 months. Case 2 was a 54-year-old woman, who was diagnosed as having PBC with CREST syndrome. Seven years later, she was diagnosed as having acute promyelocytic leukemia (APL) by bone marrow examination. Chemotherapy was continued, and her symptoms are at present, stable. To date, there have been no reports of PBC complicated by acute leukemia.
authors.affiliation: Department of Internal Medicine II, Fukushima Medical University School of Medicine, Fukushima, Japan.
authors.forename: Hironobu
authors.initials: H
authors.lastname: Saito
authors.forename: Kyoko
authors.initials: K
authors.lastname: Monoe
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Kanno
authors.forename: Atsushi
authors.initials: A
authors.lastname: Takahashi
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Rai
authors.forename: Atsushi
authors.initials: A
authors.lastname: Irisawa
authors.forename: Hiromasa
authors.initials: H
authors.lastname: Ohira
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D015153:Blotting, Western; D017675:CREST Syndrome / Q000150:complications; D051047:Dihydrolipoyllysine-Residue Acetyltransferase / Q000378:metabolism; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000150:complications* / Q000188:drug therapy; D008099:Liver / Q000473:pathology; D008105:Liver Cirrhosis, Biliary / Q000150:complications* / Q000201:enzymology / Q000473:pathology; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000188:drug therapy
chemical_list: D051047:Dihydrolipoyllysine-Residue Acetyltransferase