Symptoms after breast cancer treatment: are they influenced by patient characteristics?
OBJECTIVE
This study examines the burden of symptoms by treatment type and patient characteristics in a population-based sample of newly diagnosed breast cancer patients.


METHODS
Using the Los Angeles County SEER Registry Rapid Case Ascertainment, we identified a cohort of breast cancer patients in 2000 and conducted telephone surveys in English and Spanish among participants.


RESULTS
We completed interviews of 1,219 breast cancer patients and found almost half (46%) had at least one severe symptom (any of the following: nausea/vomiting, arm problems, hot flashes, vaginal dryness, difficulty sleeping) that interfered with her daily functioning or mood. Multi-variate analysis controlling for patient characteristics and treatment showed that older (OR=0.90; P<0.000), black (OR=0.50; P<0.000), Hispanic Spanish-speaking (OR=0.37; P<0.000), widowed or never married (OR=0.68; P=0.049), and working (OR=0.72; P=0.024) women were less likely to report severe symptoms than other women. Number of comorbid conditions (OR=1.21; P<0.000) and receipt of chemotherapy (OR=1.48; P=0.040) were positively associated with reporting symptoms.


CONCLUSIONS
These findings estimate the prevalence of several mutable symptoms in breast cancer patients that can be addressed by appropriate treatments. Comorbidity is a significant predictor of symptoms, especially amongst those receiving chemotherapy. Variation in symptom reporting occurred by race/ethnicity and other sociodemographic characteristics, raising questions of different thresholds for reporting symptoms or truly fewer symptoms for some sociodemographic groups. Population-based estimates of the probability of symptoms in women with incident breast cancer can be used to provide patient education about potential outcomes following the treatment of breast cancer.
Yoon
Jean
J
School of Public Health, Health Services, University of California at Los Angeles, Box 951772, Los Angeles, CA 90095-1722, USA.
Malin
Jennifer L
JL
Tao
May Lin
ML
Tisnado
Diana M
DM
Adams
John L
JL
Timmer
Martha J
MJ
Ganz
Patricia A
PA
Kahn
Katherine L
KL
D000203:Activities of Daily Living; D000339:Affect; D001741:Black or African American; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000453:epidemiology / Q000208:ethnology / Q000523:psychology / Q000628:therapy*; D017024:Chemotherapy, Adjuvant / Q000009:adverse effects; D015331:Cohort Studies; D015897:Comorbidity; D017281:Cost of Illness; D005260:Female; D006630:Hispanic or Latino; D006801:Humans; D015141:Los Angeles / Q000453:epidemiology; D017533:Marital Status; D008408:Mastectomy / Q000009:adverse effects*; D008875:Middle Aged; D016017:Odds Ratio; D011183:Postoperative Complications / Q000209:etiology / Q000523:psychology; D011788:Quality of Life; D018714:Radiotherapy, Adjuvant / Q000009:adverse effects; D012107:Research Design; D018570:Risk Assessment; D012307:Risk Factors; D018426:SEER Program; D012720:Severity of Illness Index; D016896:Treatment Outcome; D014931:Women, Working