Maternal hemodynamic changes associated with furosemide treatment.
OBJECTIVE
To assess the pharmacodynamic effects of furosemide in pregnancy.


METHODS
Twenty-one pregnant women who received furosemide 20 mg daily had cardiac output (CO), stroke volume (SV), and total peripheral resistance (TPR) measured by Doppler technique before and after treatment.


RESULTS
Furosemide was initiated at 22.4 +/- 6.0 weeks gestation. CO and SV decreased (mean +/- SD: 1.2 +/- 0.2 L/min and 17+/-3 mL, respectively), whereas TPR increased (101+/-26 dyne.sec.cm(-5); p < 0.001 for all) after 2.9+/-1.4 weeks. Hemodynamics did not approach the expected mean for pregnancy.


CONCLUSIONS
While furosemide improved the hyperdynamic circulation in pregnancy, it did not lower blood pressure or cause clinically significant vasoconstriction.
Carr
Darcy B
DB
Department of Obstetrics and Gynecology, University of Washington School of Medicine, Seattle, WA, USA. darcarr@u.washington.edu
Gavrila
Daniel
D
Brateng
Debra
D
Easterling
Thomas R
TR
D000328:Adult; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001262:Atenolol / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects*; D002302:Cardiac Output / Q000187:drug effects*; D004232:Diuretics / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D005665:Furosemide / Q000627:therapeutic use*; D005865:Gestational Age; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000188:drug therapy / Q000503:physiopathology; D011247:Pregnancy; D012107:Research Design; D013318:Stroke Volume / Q000187:drug effects; D016896:Treatment Outcome; D014655:Vascular Resistance / Q000187:drug effects*
D000959:Antihypertensive Agents; D004232:Diuretics; D001262:Atenolol; D005665:Furosemide