Growth factors in short-bowel syndrome patients.
Malabsorption is a key finding in patients with short-bowel syndrome. Malabsorption of nonessential and essential nutrients, fluids, and electrolytes, if not compensated for by increased intake, leads to diminished body stores and subclinical and (eventually) clinical deficiencies. After intestinal resection, adaptation (a spontaneous progressive recovery from the malabsorptive disorder) may be evident. This article describes selected factors responsible for the morphologic and functional changes in the adaptive processes and presents results of clinical trials that use either growth hormone or glucagon-like peptide-2 to facilitate a condition of hyperadaptation in short-bowel patients.
Jeppesen
Palle Bekker
PB
Department of Medical Gastroenterology, CA-2121, Rigshospitalet, Blegdamsvej 9, DK-2100 Copenhagen, Denmark. bekker@dadlnet.dk
D000222:Adaptation, Physiological / Q000187:drug effects; D001823:Body Composition / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D003404:Creatinine / Q000652:urine; D004734:Energy Metabolism / Q000187:drug effects; D053767:Glucagon-Like Peptide 2 / Q000627:therapeutic use; D005973:Glutamine / Q000627:therapeutic use; D013006:Growth Hormone / Q000627:therapeutic use*; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects; D012778:Short Bowel Syndrome / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology
D053767:Glucagon-Like Peptide 2; D005973:Glutamine; D013006:Growth Hormone; D003404:Creatinine