title: Surgical outcome in tuberous sclerosis complex: a multicenter survey.
abstract: Multicenter, retrospective analysis of 70 subjects with TSC following surgery for relief of epilepsy revealed significant associations between younger age at seizure onset, present/prior history of infantile spasms, interictal focality (bilateral versus unilateral), and absence of residual postoperative predominant tuber, and poorer postoperative outcome (p < 0.01). Ictal multifocality, mental retardation, and discordant EEG and MRI data showed a negative trend toward outcome, but were not significant.
authors.affiliation: Comprehensive Epilepsy Center, Department of Neurology, NYU Medical Center, 403 East 34th Street, New York, NY 10016, U.S.A. madhad01@med.nyu.edu
authors.forename: Deepak
authors.initials: D
authors.lastname: Madhavan
authors.forename: Sarah
authors.initials: S
authors.lastname: Schaffer
authors.forename: Alexei
authors.initials: A
authors.lastname: Yankovsky
authors.forename: Alexis
authors.initials: A
authors.lastname: Arzimanoglou
authors.forename: Florence
authors.initials: F
authors.lastname: Renaldo
authors.forename: Charles M
authors.initials: CM
authors.lastname: Zaroff
authors.forename: Josiane
authors.initials: J
authors.lastname: LaJoie
authors.forename: Howard L
authors.initials: HL
authors.lastname: Weiner
authors.forename: Eva
authors.initials: E
authors.lastname: Andermann
authors.forename: David N
authors.initials: DN
authors.lastname: Franz
authors.forename: Jennifer
authors.initials: J
authors.lastname: Leonard
authors.forename: Mary
authors.initials: M
authors.lastname: Connolly
authors.forename: Greg D
authors.initials: GD
authors.lastname: Cascino
authors.forename: Orrin
authors.initials: O
authors.lastname: Devinsky
mesh_terms: D017668:Age of Onset; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D002648:Child; D002675:Child, Preschool; D004569:Electroencephalography / Q000706:statistics & numerical data; D004828:Epilepsies, Partial / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D004827:Epilepsy / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000706:statistics & numerical data; D008297:Male; D011183:Postoperative Complications; D011300:Preoperative Care; D012189:Retrospective Studies; D016896:Treatment Outcome; D014402:Tuberous Sclerosis / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*