Neutralizing viruses in suspensions by copper oxide-based filters.
We report the capacity of copper oxide-containing filters to reduce infectious titers of a panel of viruses spiked into culture media. Enveloped, nonenveloped, RNA, and DNA viruses were affected, suggesting the possibility of using copper oxide-containing devices to deactivate a wide spectrum of infectious viruses found in filterable suspensions.
Borkow
Gadi
G
Ruth Ben-Ari Institute of Clinical Immunology, Kaplan Medical Center, Rehovot 76100, Israel. gadi@cupron.com
Sidwell
Robert W
RW
Smee
Donald F
DF
Barnard
Dale L
DL
Morrey
John D
JD
Lara-Villegas
Humberto H
HH
Shemer-Avni
Yonat
Y
Gabbay
Jeffrey
J
D000818:Animals; D001769:Blood / Q000821:virology; D002460:Cell Line; D002522:Chlorocebus aethiops; D003300:Copper / Q000494:pharmacology*; D004267:DNA Viruses / Q000187:drug effects; D004285:Dogs; D004847:Epithelial Cells / Q000821:virology; D005347:Fibroblasts / Q000821:virology; D005374:Filtration / Q000295:instrumentation / Q000379:methods; D015497:HIV-1 / Q000187:drug effects; D006367:HeLa Cells; D006801:Humans; D009500:Neutralization Tests; D012328:RNA Viruses / Q000187:drug effects; D013535:Suspensions; D014709:Vero Cells; D014780:Viruses / Q000187:drug effects*
D013535:Suspensions; D003300:Copper