Role of PKC-delta as a signal mediator in epidermal barrier homeostasis.
The skin shows an important "epidermal permeability barrier homeostasis" in response to barrier disruption. Calcium ion (Ca(2+)), a major regulator in keratinocyte differentiation and proliferation, plays a crucial role in skin barrier homeostasis. Acute barrier disruption induces an immediate depletion of both extra- and intracellular calcium ions in the epidermis, especially in the upper granular layers, and results in the loss of normal epidermal calcium gradient. Currently, we hypothesize that the change in the intracellular calcium ion concentration triggers the barrier repair responses, such as lamellar body (LB) secretion and increased lipid synthesis in the epidermis. In this article, we suggest that PKC-delta is a signaling mediator for the changes in extracellular and intracellular calcium ion concentration.
Ahn
Bong Kyun
BK
Department of Dermatology, Armed Forces Capital Hospital, Sungnam, South Korea.
Jeong
Se Kyoo
SK
Lee
Seung Hun
SH
D000818:Animals; D002118:Calcium / Q000502:physiology; D002463:Cell Membrane Permeability / Q000502:physiology; D000078404:Epidermal Cells; D004817:Epidermis / Q000502:physiology*; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D051745:Protein Kinase C-delta / Q000502:physiology*; D015398:Signal Transduction; D012879:Skin Physiological Phenomena
D051745:Protein Kinase C-delta; D002118:Calcium