title: Antinociceptive, anti-inflammatory and antipyretic properties of Melastoma malabathricum leaves aqueous extract in experimental animals.
abstract: The present study was carried out to establish the antinociceptive, anti-inflammatory, and antipyretic properties of the aqueous extract of Melastoma malabathricum leaves in experimental animals. The antinociceptive activity was measured using abdominal constriction, hot-plate, and formalin tests, whereas the anti-inflammatory and antipyretic activities were measured using carrageenan-induced paw edema and brewer's yeast-induced pyrexia tests, respectively. The extract, which was obtained after soaking the air-dried leaves in distilled water for 72 h and then preparing in concentrations of 10%, 50%, and 100% (v/v), was administered subcutaneously 30 min prior to subjection to the above mentioned assays. At all concentrations tested, the extract was found to exhibit significant (P < 0.05) antinociceptive, anti-inflammatory, and antipyretic activities in a concentration-independent manner. Our findings that the aqueous extract of M. malabathricum possesses antinociceptive, anti-inflammatory, and antipyretic activities supports previous claims on its traditional uses to treat various ailments.
authors.affiliation: Faculty of Biotechnology and Life Sciences, Universiti Industri Selangor, Jalan Zirkon A 7/A, Seksyen 7, 40000 Shah Alam, Selangor, Malaysia. shaza8174@yahoo.com
authors.forename: Z A
authors.initials: ZA
authors.lastname: Zakaria
authors.forename: R N S
authors.initials: RN
authors.lastname: Raden Mohd Nor
authors.forename: G
authors.initials: G
authors.lastname: Hanan Kumar
authors.forename: Z D F
authors.initials: ZD
authors.lastname: Abdul Ghani
authors.forename: M R
authors.initials: MR
authors.lastname: Sulaiman
authors.forename: G
authors.initials: G
authors.lastname: Rathna Devi
authors.forename: A M
authors.initials: AM
authors.lastname: Mat Jais
authors.forename: M N
authors.initials: MN
authors.lastname: Somchit
authors.forename: C A
authors.initials: CA
authors.lastname: Fatimah
mesh_terms: D019342:Acetic Acid; D000700:Analgesics / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D018712:Analgesics, Non-Narcotic / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D002351:Carrageenan; D002851:Chromatography, High Pressure Liquid; D004195:Disease Models, Animal; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control*; D005334:Fever / Q000139:chemically induced / Q000517:prevention & control*; D005557:Formaldehyde; D008297:Male; D035322:Melastomataceae; D051379:Mice; D008807:Mice, Inbred BALB C; D010146:Pain / Q000139:chemically induced / Q000517:prevention & control*; D010147:Pain Measurement; D017288:Pain Threshold / Q000187:drug effects*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D018515:Plant Leaves; D012441:Saccharomyces cerevisiae; D013997:Time Factors
chemical_list: D000700:Analgesics; D018712:Analgesics, Non-Narcotic; D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D005557:Formaldehyde; D002351:Carrageenan; D019342:Acetic Acid