Human recombination rates are increased around accelerated conserved regions--evidence for continued selection?
BACKGROUND
We hypothesized that recombination rates might be increased at genetic loci that are subject to more intense selection. Here, we test this hypothesis by using a recently published set of accelerated conserved regions and fine-scale recombination rate estimates provided by the HapMap project.


RESULTS
We observed that fine-scale recombination rates are increased around conserved noncoding regions that show accelerated evolution in human or chimp, as compared to noncoding regions showing accelerated evolution in mouse and those being conserved between human and fugu. Recombination rates around hominid accelerated conserved regions (ACRs) are furthermore increased as compared to exonic regions. On the other hand, GC-content is reduced around ACRs, excluding a major confounding influence of GC-content on the observed variation in recombination rate.


CONCLUSIONS
Our observations indicate that selection intensity could be an important determinant of local recombination rate variation and that continued positive selection might act at many ACR loci. Alternatively, a confounding factor needs to be found that causes a congruent signal in recombination rate estimates based on human polymorphism data and in the comparative genomic data. Researchers who consider the explanation involving selection as more likely may expect more common functional sequence variants at ACRs in genetic association studies.
Freudenberg
Jan
J
University of California San Francisco, Department of Neurology, Institute of Human Genetics, San Francisco, CA 94158-2922, USA. jan.freudenberg@ucsf.edu
Fu
Ying-Hui
YH
Ptácek
Louis J
LJ
D020029:Base Pairing; D001483:Base Sequence; D017124:Conserved Sequence; D019143:Evolution, Molecular; D006801:Humans; D011995:Recombination, Genetic; D012641:Selection, Genetic