Support for involvement of the AHI1 locus in schizophrenia.
Recently, markers in the Abelson Helper Integration Site 1 (AHI1) region were shown to be associated with schizophrenia in a family sample of Israeli-Arabs. Here, we report a study evaluating the relevance of the AHI1 region to schizophrenia in an Icelandic sample. Seven markers shown to confer risk in the previous report were typed in 608 patients diagnosed with broad schizophrenia and 1,504 controls. Odds ratios for the overtransmitted alleles in the Israeli-Arab families ranged from 1.15 to 1.29 in the Icelandic sample. After Bonferroni correction for the seven markers tested, two markers were significantly associated with schizophrenia. Thus, our results are in general agreement with the previous report, with the strongest association signal observed in a region upstream of the AHI1 gene.
Ingason
Andres
A
deCODE genetics, Reykjavik, Iceland.
Sigmundsson
Thordur
T
Steinberg
Stacy
S
Sigurdsson
Engilbert
E
Haraldsson
Magnus
M
Magnusdottir
Brynja B
BB
Frigge
Michael L
ML
Kong
Augustine
A
Gulcher
Jeffrey
J
Thorsteinsdottir
Unnur
U
Stefansson
Kari
K
Petursson
Hannes
H
Stefansson
Hreinn
H
D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics*; D033942:Adaptor Proteins, Vesicular Transport; D016022:Case-Control Studies; D005819:Genetic Markers; D006801:Humans; D007055:Iceland; D012559:Schizophrenia / Q000235:genetics*
C487178:AHI1 protein, human; D048868:Adaptor Proteins, Signal Transducing; D033942:Adaptor Proteins, Vesicular Transport; D005819:Genetic Markers