Effects of extract of ginkgo biloba on intracranial pressure, cerebral perfusion pressure, and cerebral blood flow in a rat model of subarachnoid haemorrhage.
The purpose of this study was to investigate in effect of extract of Ginkgo biloba (EGb) on cerebral blood perfusion in a subarachnoid haemorrhage (SAH) rat model. SAH lead to an increase in intracranial pressure and decrease in cranial perfusion pressure and regional cerebral blood flow in all groups. However, the intracranial pressure increases in EGb groups were less than that of the vehicle group (p < .01), whereas the reduction in cranial perfusion pressure and regional cerebral blood flow in the EGb group was less than that of the vehicle and SAH groups (p < .01). It was concluded that EGb attenuates the increase in intracranial pressure and reduction in cerebral blood perfusion after SAH.
Sun
Bao-Liang
BL
Department of Neurology & Institute of Microcirculation Affiliated Hospital, Taishan Medical College, Shandong, China.
Yuan
Hui
H
Yang
Ming-Feng
MF
Xia
Zuo-Li
ZL
Zhang
Su-Ming
SM
Wang
Le-Xin
LX
D000704:Analysis of Variance; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002540:Cerebral Cortex / Q000098:blood supply / Q000187:drug effects*; D002560:Cerebrovascular Circulation / Q000187:drug effects; D004195:Disease Models, Animal; D005260:Female; D020441:Ginkgo biloba / Q000737:chemistry*; D007427:Intracranial Pressure / Q000187:drug effects*; D017078:Laser-Doppler Flowmetry / Q000379:methods; D008297:Male; D010477:Perfusion; D010936:Plant Extracts / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D012039:Regional Blood Flow / Q000187:drug effects; D013345:Subarachnoid Hemorrhage / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D013997:Time Factors
D010936:Plant Extracts