Cleveland Clinic PediPump lamb cadaver fitting studies.
We are developing the PediPump, a magnetically suspended, mixed-flow pump, as an implantable pediatric ventricular assist device (VAD). Lamb cadaver fitting studies were performed to determine the optimal pump location and optimal design of the inflow and outflow conduits for chronic in vivo studies. A prototype of the PediPump right and left ventricular assist devices (RVAD and LVAD, respectively) were implanted via a sternotomy or left thoracotomy in four lamb cadavers (3.7-34.2 kg). Via a sternotomy, the RVAD and LVAD required long inflow cannulas when placed into the right or left thoracic cavities, respectively. Via a left thoracotomy, with both pumps implanted in the left thoracic cavity, the RVAD required a 70 degrees inflow cannula and a bent outflow graft while the LVAD required a 130 degrees inflow cannula and a straight outflow graft. In conclusion, left thoracotomy provided optimal fitting for both LVAD and RVAD for the small lamb model.
Cingoz
Faruk
F
Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
Fukamachi
Kiyotaka
K
Ootaki
Yoshio
Y
Kamohara
Keiji
K
Akiyama
Masatoshi
M
Ootaki
Chiyo
C
Kopcak
Michael W
MW
Liu
Jenny
J
Noecker
Angela
A
Dudzinski
Dave
D
Smith
William A
WA
Duncan
Brian W
BW
D000818:Animals; D002648:Child; D004867:Equipment Design; D006353:Heart-Assist Devices; D006801:Humans; D023421:Models, Animal; D019919:Prosthesis Implantation / Q000379:methods*; D012756:Sheep; D013908:Thoracotomy; D014057:Tomography, X-Ray Computed