Acute Marchiafava-Bignami disease: diffusion-weighted MRI in cortical and callosal involvement.
Marchiafava-Bignami disease (MBD) is a fatal disorder characterized by demyelination of the corpus callosum. MRI, suggestive of corpus callosum demyelination with associated white matter involvement in both cerebral hemispheres, indicates a diagnosis of MBD. In this case, MR diffusion-weighted findings taken at an acute stage of MBD revealed lesions not only in the corpus callosum but also in the cerebral cortex. Lower apparent diffusion coefficient values of the corpus callosum and cortical lesions were associated with poor clinical outcome.
Ihn
Yon Kwon
YK
Department of Radiology, St Vincent Hospital, The Catholic University of Korea, 93-6 Ji-Dong, Paldal-Gu, Suwon-Si, Gyenggi-Do, Korea. Ihn@catholic.ac.kr
Hwang
Seong Su
SS
Park
Young Ha
YH
D000437:Alcoholism / Q000150:complications; D001921:Brain / Q000473:pathology*; D003337:Corpus Callosum / Q000473:pathology*; D003711:Demyelinating Diseases / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged