title: A services oriented system for bioinformatics applications on the grid.
abstract: This paper describes the evolution of the main services of the ProGenGrid (Proteomics & Genomics Grid) system, a distributed and ubiquitous grid environment ("virtual laboratory"), based on Workflow and supporting the design, execution and monitoring of "in silico" experiments in bioinformatics.ProGenGrid is a Grid-based Problem Solving Environment that allows the composition of data sources and bioinformatics programs wrapped as Web Services (WS). The use of WS provides ease of use and fosters re-use. The resulting workflow of WS is then scheduled on the Grid, leveraging Grid-middleware services. In particular, ProGenGrid offers a modular bag of services and currently is focused on the biological simulation of two important bioinformatics problems: prediction of the secondary structure of proteins, and sequence alignment of proteins. Both services are based on an enhanced data access service.
authors.affiliation: CACT-NNL/CNR-INFM, CMCC, University of Salento, Lecce, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Aloisio
authors.forename: Massimo
authors.initials: M
authors.lastname: Cafaro
authors.forename: Italo
authors.initials: I
authors.lastname: Epicoco
authors.forename: Sandro
authors.initials: S
authors.lastname: Fiore
authors.forename: Maria
authors.initials: M
authors.lastname: Mirto
mesh_terms: D022126:Access to Information; D019295:Computational Biology; D020407:Internet; D007558:Italy; D008490:Medical Informatics; D011340:Problem Solving; D040901:Proteomics