title: [The smoothness index of betaxolol hydrochloride in patients with newly diagnosed hypertension].
abstract: BACKGROUND
  24-hour ambulatory blood pressure monitoring (ABPM) has a higher predictive value for cardiovascular diseases than occasional blood pressure (BP) measurement with sphygmomanometer. ABPM allows for the assessment of 24-hour effect of drugs administered once a day using the smoothness index (SI) method. OBJECTIVE OF WORK: Find out the 24-hour effect of betaxolol hydrochloride administered once a day by determining the smoothness index. Cohort and methodology: Examination of 30 newly diagnosed hypertonics prior to and after 3-month treatment with betaxolol hydrochloride at an average dose of 15 mg once a day. BP measurement using sphygmomanometer and ABPM (SpaceLabs 90207) according to European Society for Hypertension criteria. Determining the smoothness index from individual average hourly changes in BP after treatment by dividing the hourly values average by standard deviation. Calculation of average SI from individual patient data with standard deviation and 95% confidence interval (95% CI).
  
  
  RESULTS
  The calculated SI value of betaxolol hydrochloride was 1.03 +/- 0.65 (95% CI, 0.80 to 1.26) and 1.27 +/- 0.89 (95% CI, 0.95 to 1.59) for systolic and diastolic BP, respectively.
  
  
  CONCLUSIONS
  Average SI of betaxolol hydrochloride is higher than 1 when both systolic and diastolic BP is measured. Based on the above parameter, the monitored drug has a sufficient 24-hour effect and can be administered once a day.
authors.affiliation: II interní klinika Lékarské fakulty MU a FN u sv. Anny, Brno. ivan.rihacek@fnusa.cz
authors.forename: I
authors.initials: I
authors.lastname: Rihácek
authors.forename: M
authors.initials: M
authors.lastname: Soucek
authors.forename: P
authors.initials: P
authors.lastname: Frána
mesh_terms: D000959:Antihypertensive Agents / Q000627:therapeutic use*; D015784:Betaxolol / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects*; D018660:Blood Pressure Monitoring, Ambulatory; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged
chemical_list: D000959:Antihypertensive Agents; D015784:Betaxolol