Pharmacokinetics of a single oral dose of 1.5-mg levonorgestrel when administered as 750-mug tablets or as 30-microg minipills.
We examined the pharmacokinetics of a single dose of 1.5 mg of levonorgestrel when administered orally in two different formulations: two tablets of 0.75 mg or 50 minipills of 30 microg of levonorgestrel. Bioavailability of levonorgestrel with minipills was comparable to that with levonorgestrel tablets. These findings suggest that levonorgestrel-containing minipills can be considered as an alternative to standard levonorgestrel tablets for use in emergency contraception.
Devoto
Luigi
L
Instituto de Investigaciones Materno Infantil and Departamento de Obstetricia y Ginecologia, Universidad de Chile, Santiago, Chile. ldevoto@med.uchile.cl
Espinoza
Alejandra
A
Muñoz
Alex
A
Fuentes
Ariel
A
von Hertzen
Helena
H
D000328:Adult; D001682:Biological Availability; D044363:Contraception, Postcoital / Q000379:methods; D005260:Female; D006801:Humans; D016912:Levonorgestrel / Q000008:administration & dosage* / Q000493:pharmacokinetics*
D016912:Levonorgestrel