Magnetic resonance imaging and its role in myocardial regenerative therapy.
There has been extensive interest recently in cardiac stem cell therapy. Current research has been hampered by differences in cell type, methods of delivery and efficacy evaluation. In this article we review the use of magnetic resonance imaging in this growing area and argue that it is well suited to all areas of myocardial regeneration: from patient identification, through cell delivery and tracking of appropriately labeled cells, to evaluation of therapeutic effect. Potential future advances are discussed including magnetic resonance imaging-guided intervention suites and the use of higher field strength magnets for cell tracking.
Graham
John J
JJ
Division of Cardiology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
Lederman
Robert J
RJ
Dick
Alexander J
AJ
D000818:Animals; D005544:Forecasting; D006801:Humans; D008279:Magnetic Resonance Imaging; D009206:Myocardium / Q000166:cytology / Q000473:pathology*; D012038:Regeneration