title: Synthesis, characterization and cytolytic activity of alpha-helical amphiphilic peptide nanostructures containing crown ethers.
abstract: Many natural alpha-helical amphiphilic peptides are known to have lytic activity toward different cells. Herein, we describe the synthesis and the characterization of synthetic alpha-helical amphiphilic peptide nanostructures containing crown ethers, as well as the modulation of their cytolytic activity by adding different acidic dipeptide chains at the N- or C-terminus.
authors.affiliation: Département de chimie and Centre de recherche sur la fonction, la structure et l'ingénierie des protéines, Faculté des sciences et génie, Université Laval, Québec, CanadaG1K 7P4.
authors.forename: Pierre-Luc
authors.initials: PL
authors.lastname: Boudreault
authors.forename: Normand
authors.initials: N
authors.lastname: Voyer
mesh_terms: D000595:Amino Acid Sequence; D002942:Circular Dichroism; D043844:Crown Ethers / Q000737:chemistry*; D005452:Fluoresceins / Q000737:chemistry; D008969:Molecular Sequence Data; D049329:Nanostructures / Q000737:chemistry*; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry*; D017433:Protein Structure, Secondary; D053835:Unilamellar Liposomes
chemical_list: D043844:Crown Ethers; D005452:Fluoresceins; D010455:Peptides; D053835:Unilamellar Liposomes; C007740:fluorexon