A two-way street: LSD1 regulates chromatin boundary formation in S. pombe and Drosophila.
Two recent studies in Molecular Cell (Lan et al., 2007; Rudolph et al., 2007) implicate histone demethylation by LSD1 in the regulation of boundaries between silenced and active chromatin domains in both fission yeast and flies, but by distinct mechanisms.
Chosed
Renee
R
Program in Genes and Development, Department of Biochemistry and Molecular Biology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.
Dent
Sharon Y R
SY
D000818:Animals; D002843:Chromatin / Q000201:enzymology* / Q000235:genetics*; D029721:Drosophila Proteins / Q000235:genetics* / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000201:enzymology* / Q000235:genetics*; D022041:Euchromatin / Q000201:enzymology / Q000235:genetics; D005800:Genes, Fungal; D017344:Genes, Insect; D006570:Heterochromatin / Q000201:enzymology / Q000235:genetics; D006657:Histones / Q000378:metabolism; D008954:Models, Biological; D010089:Oxidoreductases, N-Demethylating / Q000235:genetics* / Q000378:metabolism*; D012568:Schizosaccharomyces / Q000201:enzymology* / Q000235:genetics*; D029702:Schizosaccharomyces pombe Proteins / Q000235:genetics / Q000378:metabolism
D002843:Chromatin; D029721:Drosophila Proteins; D022041:Euchromatin; D006570:Heterochromatin; D006657:Histones; D029702:Schizosaccharomyces pombe Proteins; D010089:Oxidoreductases, N-Demethylating