title: Inhibition of pro-inflammatory enzymes by inuviscolide, a sesquiterpene lactone from Inula viscosa.
abstract: This work concerns the pharmacological activity of inuviscolide, a sesquiterpenoid from Inula viscosa. It exerts inhibitory effects on elastase, cyclooxygenase 1 and secretory phospholipase A(2). Furthermore, it reduces the skin leukocyte infiltration in a murine model of dermatitis induced by repeated application of 12-O-tetradecanoylphorbol 13-acetate.
authors.affiliation: Departament de Farmacologia, Facultat de Farmàcia, Universitat de València, Avinguda Vicent Andrés Estellés s/n, 46100 Burjassot, Spain. manez@uv.es
authors.forename: Salvador
authors.initials: S
authors.lastname: Máñez
authors.forename: Victoriano
authors.initials: V
authors.lastname: Hernández
authors.forename: Rosa-María
authors.initials: RM
authors.lastname: Giner
authors.forename: José-Luis
authors.initials: JL
authors.lastname: Ríos
authors.forename: María Del Carmen
authors.initials: Mdel C
authors.lastname: Recio
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D003872:Dermatitis / Q000188:drug therapy / Q000209:etiology; D004791:Enzyme Inhibitors / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D038143:Inula; D007783:Lactones / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D007962:Leukocytes / Q000201:enzymology; D051379:Mice; D010196:Pancreatic Elastase / Q000037:antagonists & inhibitors / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D012717:Sesquiterpenes / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D013755:Tetradecanoylphorbol Acetate
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004791:Enzyme Inhibitors; D007783:Lactones; D010936:Plant Extracts; D012717:Sesquiterpenes; C458886:inuviscolide; D010196:Pancreatic Elastase; D013755:Tetradecanoylphorbol Acetate