The structural basis of glycosidase inhibition by five-membered iminocyclitols: the clan a glycoside hydrolase endoglycoceramidase as a model system.
Caines
Matthew E C
ME
Department of Biochemistry and Molecular Biology, University of British Columbia, 2350 Health Sciences Mall, Vancouver, BC V6T 1Z3, Canada.
Hancock
Susan M
SM
Tarling
Chris A
CA
Wrodnigg
Tanja M
TM
Stick
Robert V
RV
Stütz
Arnold E
AE
Vasella
Andrea
A
Withers
Stephen G
SG
Strynadka
Natalie C J
NC
D004791:Enzyme Inhibitors / Q000737:chemistry; D006026:Glycoside Hydrolases / Q000037:antagonists & inhibitors*; D050111:Imino Sugars / Q000737:chemistry / Q000494:pharmacology*; D011485:Protein Binding; D055672:Static Electricity; D013329:Structure-Activity Relationship; D014867:Water
D004791:Enzyme Inhibitors; D050111:Imino Sugars; D014867:Water; D006026:Glycoside Hydrolases; C050427:endoglycoceramidase