Synthesis and characterization of a dehydrogenation product arising from the oxidation of aminoethylcysteine ketimine decarboxylated dimer.
While investigating the antioxidant properties of aminoethylcysteine ketimine decarboxylated dimer (1) (a natural substance occurring in biological fluids such as human urine and plasma and in bovine cerebellum), a previously unreported oxidation product was obtained. This compound was identified and characterized through comparison with an authentic sample prepared via Pd-catalyzed dehydrogenation of 1. This molecule is an example of an alternative oxidation pathway involving 1.
Macone
Alberto
A
Department of Biochemical Sciences A. Rossi-Fanelli and National Research Council Institute of Molecular Biology and Pathology, University of Rome La Sapienza, Piazzale Aldo Moro 5, 00185 Rome, Italy.
Caiazzo
Aldo
A
Antonucci
Antonio
A
Fochi
Igor
I
Nardini
Mirella
M
Duprè
Silvestro
S
Matarese
Rosa Marina
RM
D000818:Animals; D000975:Antioxidants / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002417:Cattle; D002531:Cerebellum / Q000737:chemistry; D006801:Humans; D015394:Molecular Structure; D009025:Morpholines / Q000097:blood / Q000138:chemical synthesis* / Q000737:chemistry / Q000652:urine; D010084:Oxidation-Reduction; D010165:Palladium / Q000737:chemistry
C086349:5,9a-dihydro-5-oxopyrrolo(2,1-c-3,4-b')dithiomorpholine; D000975:Antioxidants; D009025:Morpholines; D010165:Palladium