Antitumor anthraquinones from an endophytic actinomycete Micromonospora lupini sp. nov.
Two novel anthraquinones, lupinacidins A (1) and B (2), have been isolated from the culture broth of a new endophytic actinomycete belonging to the genus Micromonospora. Lupinacidins were found to show significant inhibitory effects on the invasion of murine colon 26-L5 carcinoma cells without inhibiting cell growth.
Igarashi
Yasuhiro
Y
Biotechnology Research Center, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama, Japan. yas@pu-toyama.ac.jp <yas@pu-toyama.ac.jp>
Trujillo
Martha E
ME
Martínez-Molina
Eustoquio
E
Yanase
Saeko
S
Miyanaga
Satoshi
S
Obata
Takamasa
T
Sakurai
Hiroaki
H
Saiki
Ikuo
I
Fujita
Tsuyoshi
T
Furumai
Tamotsu
T
D000818:Animals; D000880:Anthraquinones / Q000138:chemical synthesis* / Q000737:chemistry; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D003110:Colonic Neoplasms / Q000188:drug therapy; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008847:Micromonospora; D008956:Models, Chemical; D008968:Molecular Conformation
D000880:Anthraquinones; D000970:Antineoplastic Agents