Direct chemiluminescence determination of ibuprofen by the enhancement of the KMnO(4)-sulphite reaction.
A simple, rapid, flow-injection chemiluminescence (CL) method is described for the determination of ibuprofen. A strong CL signal was detected when a mixture of the analyte and sulphite was injected into acidic KMnO(4). The CL signal is proportional to the concentration of ibuprofen in the range 0.1-10.0 mg/L. The detection limit is 0.02 mg/L ibuprofen, the relative standard deviation is 1.8% (0.5 mg/L ibuprofen; n = 11) and the sample measurement frequency is 120/h. The proposed method was successfully applied to the determination of ibuprofen in pharmaceutical preparations and in spiked urine samples. The mechanism of the CL reaction is also discussed.
Li
Yinhuan
Y
School of Chemistry and Materials Science, Shaanxi Normal University, Xi'an 710062, People's Republic of China.
Lu
Jiuru
J
D017022:Flow Injection Analysis / Q000379:methods; D007052:Ibuprofen / Q000032:analysis*; D008163:Luminescent Measurements / Q000379:methods*; D008722:Methods; D004364:Pharmaceutical Preparations / Q000032:analysis; D011196:Potassium Permanganate / Q000737:chemistry; D015203:Reproducibility of Results; D013447:Sulfites / Q000737:chemistry
D004364:Pharmaceutical Preparations; D013447:Sulfites; D011196:Potassium Permanganate; D007052:Ibuprofen