Regulation of drug transporters during infection and inflammation.
Inflammation-induced changes in the pharmacokinetics and dynamics of numerous drugs have been reported. Altered drug disposition during inflammatory disease has traditionally been ascribed primarily to changes in drug metabolism and protein binding. Emerging evidence within the last decade, however, has demonstrated that the inflammatory response affects the expression of several important drug transporters and these changes significantly impact the disposition and activity of drug substrates.
Petrovic
Vanja
V
Department of Pharmaceutical Sciences, University of Toronto, Ontario, Canada.
Teng
Shirley
S
Piquette-Miller
Micheline
M
D018528:ATP-Binding Cassette Transporters / Q000378:metabolism*; D000210:Acute-Phase Reaction; D000818:Animals; D001921:Brain / Q000378:metabolism; D027682:Cation Transport Proteins / Q000378:metabolism*; D005260:Female; D006801:Humans; D007239:Infections / Q000188:drug therapy / Q000378:metabolism*; D007249:Inflammation / Q000188:drug therapy / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008954:Models, Biological; D010920:Placenta / Q000378:metabolism; D011247:Pregnancy; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism
D018528:ATP-Binding Cassette Transporters; D027682:Cation Transport Proteins; D018160:Receptors, Cytoplasmic and Nuclear