title: Triterpenoids from Schisandra rubriflora.
abstract: Investigation of an organic extract of Schisandra rubriflora led to the isolation of three new highly oxygenated nortriterpenoids, named rubriflorins A-C (1-3), together with six related known compounds (4-9). Their structures were elucidated by spectroscopic evidence. Compounds 1-3 feature the opening of ring A compared with related known nortriterpenoids isolated from the genus Schisandra and showed anti-HIV-1 activities with EC50 values of 10.0, 16.2, and 81.3 microg/mL, respectively.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, People's Republic of China.
authors.forename: Wei-Lie
authors.initials: WL
authors.lastname: Xiao
authors.forename: Xiao-Li
authors.initials: XL
authors.lastname: Li
authors.forename: Rui-Rui
authors.initials: RR
authors.lastname: Wang
authors.forename: Liu-Meng
authors.initials: LM
authors.lastname: Yang
authors.forename: Li-Mei
authors.initials: LM
authors.lastname: Li
authors.forename: Sheng-Xiong
authors.initials: SX
authors.lastname: Huang
authors.forename: Jian-Xin
authors.initials: JX
authors.lastname: Pu
authors.forename: Yong-Tang
authors.initials: YT
authors.lastname: Zheng
authors.forename: Rong-Tao
authors.initials: RT
authors.lastname: Li
authors.forename: Han-Dong
authors.initials: HD
authors.lastname: Sun
mesh_terms: D019380:Anti-HIV Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015497:HIV-1 / Q000187:drug effects*; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D032141:Schisandra / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D019380:Anti-HIV Agents; D004365:Drugs, Chinese Herbal; D014315:Triterpenes; C521652:rubriflorin A; C521653:rubriflorin B; C521654:rubriflorin C