Assessment of buprenorphine, carprofen, and their combination for postoperative analgesia in olive baboons (Papio anubis).
This study compared the efficacy of buprenorphine, carprofen, and a combination of the 2 analgesics in female baboons. Physiologic and behavioral parameters were assessed at baseline and postoperatively for 6 d by use of continuous noninvasive physiologic monitoring and twice-daily videotaping. Prior to surgery, all animals received a pre-emptive dose of either 0.01 mg/kg buprenorphine intramuscularly, 2.2 mg/kg carprofen intramuscularly, or a combination of 0.01 mg/kg buprenorphine and 2.2 mg/kg carprofen intramuscularly. All animals in the carprofen (n = 4) and buprenorphine+carprofen (n = 4) treatment groups appeared to have sufficient analgesia. Three of 4 animals in the buprenorphine group had adequate analgesia. The fourth animal had an elevated heart rate and spent less time standing during the postoperative period. In this study, the use of carprofen or a combination of carprofen plus buprenorphine provided more reliable postoperative analgesia than buprenorphine alone.
Allison
Sarah O
SO
Division of Animal Resources, University of Illinois at Urbana Champaign, IL, USA. allison3@uiuc.edu
Halliday
Lisa C
LC
French
Jeffrey A
JA
Novikov
Dmitri D
DD
Fortman
Jeffrey D
JD
D000700:Analgesics / Q000627:therapeutic use*; D000818:Animals; D001835:Body Weight; D002047:Buprenorphine / Q000627:therapeutic use*; D002227:Carbazoles / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005247:Feeding Behavior; D005260:Female; D006854:Hydrocortisone / Q000097:blood / Q000652:urine; D010147:Pain Measurement; D010149:Postoperative Pain / Q000517:prevention & control / Q000662:veterinary*; D048530:Papio anubis / Q000033:anatomy & histology / Q000502:physiology / Q000601:surgery*
D000700:Analgesics; D002227:Carbazoles; D002047:Buprenorphine; C007005:carprofen; D006854:Hydrocortisone