title: [A case of intravascular large cell lymphoma with pulmonary invasion].
abstract: A 60-year-old man was admitted to our hospital because of dyspnea, cough, and fever two weeks after participating demolition work. Computed tomography of the chest showed multiple diffuse interstitial shadows. While fibrotic bronchoscopy and transbronchial lung biopsy showed alveolitis. We diagnosed hypersensitivity pneumonitis (HP) and treated with mPSL-pulse therapy then got better soon, and also chest abnormal shadow disappeared. Two month later he was admitted because of the same symptom. His chest CT-scans showed diffuse interstitial shadows and we diagnosed recurrence of HP. Treatment with mPSL pulse-therapy was not effective. Acute respiratory failure appeared and progressed daily. The patient died 3 weeks after admission. The final diagnosis of autopsy is angiotrophic large cell lymphoma, a very rare type of lymphoma (<1% of NHL). It is important to consider angiotrophic large cell lymphoma in the differential diagnosis of diffuse interstitial lung disease.
authors.affiliation: Department of Internal Medicine, Funabashi Municipal Medical Center.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Sakurai
authors.forename: Atsuko
authors.initials: A
authors.lastname: Tokud
authors.forename: Sukeyuki
authors.initials: S
authors.lastname: Nakamur
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tabet
mesh_terms: D000542:Alveolitis, Extrinsic Allergic / Q000000981:diagnostic imaging*; D003937:Diagnosis, Differential; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D016403:Lymphoma, Large B-Cell, Diffuse / Q000000981:diagnostic imaging* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D014057:Tomography, X-Ray Computed