title: Renal tuberculosis in adult polycystic kidney disease: report of 2 cases and review of the literature.
abstract: Adult polycystic kidney disease (APKD) is a common and potentially fatal disease, leading to end-stage renal failure in 50% of cases. The disease is frequently complicated by arterial hypertension, bacterial pyelonephritis, and hematuria. The association between APKD and tuberculosis has rarely been reported and is related to a more unfavorable course since the infection becomes refractory to specific treatment. The authors report 2 cases of renal tuberculosis diagnosed in the native nephrectomy specimens of 2 patients with APKD after renal transplantation. Tuberculosis, although not common, must be recognized as a potential source of infection of native polycystic kidneys in immunocompromised transplant recipients.
authors.affiliation: Department of Pathology, Paulista School of Medicine of Federal University of São Paulo, Brazil.
authors.forename: Kleber
authors.initials: K
authors.lastname: Simões do Espírito Santo
authors.forename: Vicente de Paulo Castro
authors.initials: Vde P
authors.lastname: Teixeira
authors.forename: Henrique de Oliveira
authors.initials: Hde O
authors.lastname: Costa
authors.forename: Marcello
authors.initials: M
authors.lastname: Franco
mesh_terms: D000995:Antitubercular Agents / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D017809:Fatal Outcome; D006801:Humans; D016867:Immunocompromised Host; D016030:Kidney Transplantation / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D009161:Mycobacterium / Q000302:isolation & purification; D009392:Nephrectomy; D009894:Opportunistic Infections / Q000209:etiology; D007690:Polycystic Kidney Diseases / Q000382:microbiology / Q000473:pathology*; D011183:Postoperative Complications / Q000209:etiology; D014398:Tuberculosis, Renal / Q000188:drug therapy / Q000209:etiology / Q000473:pathology*
chemical_list: D000995:Antitubercular Agents