[Chronic heart failure: structural and microbiological changes in the colon].
OBJECTIVE
To study microbiocenosis of the parietal layer of the colon and feces, concentrations of endotoxin and proinflammatory cytokines in patients with chronic heart failure (CHF) of different functional classes vs. healthy subjects of the same age.


METHODS
The trial includes 37 patients with ischemic CHF and 13 healthy volunteers. The examination comprised 6-min walking test, echocardiographic evaluation of the left ventricular ejection fraction, clinical state by a special scale, assay for C-reactive protein, endotoxin, fecal seeding, colonoscopy with biopsy and seeding.


RESULTS
Gram-negative flora in the colon and parietal layer occurred in high concentrations correlating with severity of CHF. The examinees with CHF of functional class III-IV had elevated levels of circulating endotoxin and serum C-reactive protein.
Arutiunov
G P
GP
Kafarskaia
L I
LI
Savelov
N A
NA
Bylova
N A
NA
Cherniavskaia
T K
TK
Pokrovskiĭ
Iu A
IuA
Korsunskaia
M I
MI
Chernaia
Z A
ZA
Resnenko
A B
AB
Kokosidze
N V
NV
D002097:C-Reactive Protein / Q000276:immunology; D002908:Chronic Disease; D003109:Colonic Diseases, Functional / Q000453:epidemiology / Q000276:immunology / Q000382:microbiology; D016207:Cytokines / Q000276:immunology*; D004452:Echocardiography; D004731:Endotoxins / Q000276:immunology; D005260:Female; D006090:Gram-Negative Bacteria / Q000302:isolation & purification; D006333:Heart Failure / Q000453:epidemiology* / Q000276:immunology*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged
D016207:Cytokines; D004731:Endotoxins; D002097:C-Reactive Protein