title: Serum leptin, oxidized low density lipoprotein and plasma asymmetric dimethylarginine levels and their relationship with dyslipidaemia in adolescent girls with polycystic ovary syndrome.
abstract: OBJECTIVE
  The aim of this study was to investigate serum leptin, oxidized low density lipoprotein (ox-LDL) and asymmetric dimethylarginine (ADMA) levels and their interaction with dyslipidaemia in adolescents with polycystic ovary syndrome (PCOS).
  
  
  METHODS
  The study group consisted of 23 obese (obPCOS) and 21 nonobese girls with PCOS (nPCOS), and 31 lean healthy controls. PCOS was defined by the National Institutes of Health (NIH) criteria as the presence of chronic oligoanovulation and hyperandrogenism. Fasting leptin, ox-LDL, ADMA and detailed lipid-lipoprotein profile were determined. Atherogenic index (AI) was calculated as [Total cholesterol - HDL cholesterol/HDL cholesterol]. Logarithmic transformations were made for ox-LDL.
  
  
  RESULTS
  Total cholesterol, triglycerides, LDL cholesterol, very low density lipoprotein (VLDL) cholesterol, apolipoprotein B, lipoprotein A levels and AI were higher and apolipoprotein AI was lower in obPCOS compared to those in controls (P < 0.05). LDL cholesterol, apolipoprotein B and lipoprotein A levels were higher in nPCOS compared to controls (P < 0.05). ADMA and ox-LDL levels did not differ in the three groups. Leptin was significantly higher in obPCOS compared with that in the other two groups (P < 0.001) and it was correlated with triglycerides (r = 0.62), VLDL cholesterol (r = 0.45), lipoprotein A (r = 0.38) and AI (r = 0.43) in the PCOS group (P < 0.05).
  
  
  CONCLUSIONS
  Our data demonstrate that ADMA and ox-LDL levels in adolescent PCOS subjects were not different than those in controls. Abnormal lipid profile was shown in obese and nonobese girls with PCOS and leptin was related with these lipid abnormalities in the PCOS subjects.
authors.affiliation: Department of Pediatric Endocrinology, Gazi University, Medical Faculty, Ankara, Turkey. demirelf@gmail.com
authors.forename: Fatma
authors.initials: F
authors.lastname: Demirel
authors.forename: Aysun
authors.initials: A
authors.lastname: Bideci
authors.forename: Peyami
authors.initials: P
authors.lastname: Cinaz
authors.forename: M Orhun
authors.initials: MO
authors.lastname: Camurdan
authors.forename: Gürsel
authors.initials: G
authors.lastname: Biberoğlu
authors.forename: Ediz
authors.initials: E
authors.lastname: Yesilkaya
authors.forename: Alev
authors.initials: A
authors.lastname: Hasanoğlu
mesh_terms: D000293:Adolescent; D001055:Apolipoproteins B / Q000097:blood; D001120:Arginine / Q000031:analogs & derivatives* / Q000097:blood; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D002784:Cholesterol / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D050171:Dyslipidemias / Q000097:blood*; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood*; D017270:Lipoprotein(a) / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood*; D008079:Lipoproteins, VLDL / Q000097:blood; D015999:Multivariate Analysis; D009765:Obesity / Q000097:blood*; D011085:Polycystic Ovary Syndrome / Q000097:blood*; D014280:Triglycerides / Q000097:blood
chemical_list: D001055:Apolipoproteins B; D015415:Biomarkers; D008078:Cholesterol, LDL; D020738:Leptin; D017270:Lipoprotein(a); D008077:Lipoproteins, LDL; D008079:Lipoproteins, VLDL; D014280:Triglycerides; C099252:oxidized low density lipoprotein; C018524:N,N-dimethylarginine; D001120:Arginine; D002784:Cholesterol