CD109, a new marker for myoepithelial cells of mammary, salivary, and lacrimal glands and prostate basal cells.
The CD109 gene encodes a glycosylphosphatidylinositol (GPI)-anchored cell surface protein. Herein it is shown that CD109 is highly expressed in myoepithelial cells of mammary, salivary, and lacrimal glands; and in prostate basal cells. The anti-CD109 antibody generated by the authors was available for formalin-fixed paraffin section, and it strongly stained myoepithelial cells and basal cells but not ductal, acinar, and secretory cells in these glands. CD109 expression was negative in examined breast ductal carcinomas and prostate adenocarcinomas. These findings indicate that CD109 is a useful marker for the diagnosis of invasive breast and prostate carcinomas.
Hasegawa
Masaki
M
Department of Pathology, Nagoya University Graduate School of Medicine, and Department of Pathology, National Hospital Organization, Nagoya Medical Center, Nagoya, Japan.
Hagiwara
Sumitaka
S
Sato
Tomoko
T
Jijiwa
Mayumi
M
Murakumo
Yoshiki
Y
Maeda
Masahiro
M
Moritani
Suzuko
S
Ichihara
Shu
S
Takahashi
Masahide
M
D015703:Antigens, CD / Q000032:analysis* / Q000235:genetics; D015415:Biomarkers / Q000032:analysis*; D015153:Blotting, Western; D001943:Breast Neoplasms / Q000378:metabolism / Q000473:pathology; D002460:Cell Line; D045744:Cell Line, Tumor; D005260:Female; D058851:GPI-Linked Proteins; D006801:Humans; D007150:Immunohistochemistry; D007765:Lacrimal Apparatus / Q000737:chemistry / Q000166:cytology; D008297:Male; D042361:Mammary Glands, Human / Q000737:chemistry / Q000166:cytology; D009363:Neoplasm Proteins / Q000032:analysis* / Q000235:genetics; D011467:Prostate / Q000737:chemistry / Q000166:cytology; D011471:Prostatic Neoplasms / Q000378:metabolism / Q000473:pathology; D034622:RNA Interference; D012468:Salivary Gland Neoplasms / Q000378:metabolism / Q000473:pathology; D012469:Salivary Glands / Q000737:chemistry / Q000166:cytology; D014162:Transfection
D015703:Antigens, CD; D015415:Biomarkers; C120523:CD109 protein, human; D058851:GPI-Linked Proteins; D009363:Neoplasm Proteins