title: Subclinical hypothyroidism and deep venous thrombosis. A pilot cross-sectional study.
abstract: Several in-vivo studies have shown a procoagulant state in both overt and subclinical hyperthyroidism and in subclinical hypothyroidism. Insofar, no clinical studies have ever evaluated the relationship between thyroid dysfunction and clinically deep venous thrombosis (DVT). A pilot cross-sectional study aimed at assessing the frequency of overt and subclinical thyroid dysfunction patients with DVT was carried out. Fifty consecutive adult outpatients with a previous diagnosis of provoked DVT (pDVT), and 50 consecutive adult outpatients with a previous diagnosis unprovoked DVT (unDVT), both of the lower legs, who were followed at the Thrombosis Unit of the University Hospital of Varese, Italy, were enrolled after written informed consent. Fifty subjects, in whom such a diagnosis could be ruled out, served as controls. In each patient serum free thyroxine (FT4), free triiodothyronine (FT3), thyrotropin (TSH), anti-thyroid peroxidase (AbTPO), and anti-thyroglobulin (AbTg) antibodies were assayed. Previously unrecognised subclinical hypothyroidism was diagnosed in seven (14.0%) unDVT patients, one (2%) pDVT patient, and one (2%) control (odds ratio at multivariate analysis, 5.54; 95% confidence interval, 0.6-52.6); one new case of subclinical hyperthyroidism was diagnosed in each group; only one case (in the control group) of clinical overt hyperthyroidism was observed. The prevalence of thyroid autoantibodies, including both euthyroid and subclinical hypothyroid patients, did not differ in the three groups. The results of this pilot study suggest an increased prevalence of subclinical hypothyroidism in patients with unDVT. The clinical relevance of these preliminary findings needs to be addressed in larger prospective studies.
authors.affiliation: Department of Clinical Medicine, University of Insubria, Ospedale di Circolo, viale Borri 57, 21100 Varese, Italy. alexsquizzo@libero.it
authors.forename: Alessandro
authors.initials: A
authors.lastname: Squizzato
authors.forename: Erica
authors.initials: E
authors.lastname: Romualdi
authors.forename: Eliana
authors.initials: E
authors.lastname: Piantanida
authors.forename: Victor E A
authors.initials: VE
authors.lastname: Gerdes
authors.forename: Harry R
authors.initials: HR
authors.lastname: Büller
authors.forename: Maria
authors.initials: M
authors.lastname: Tanda
authors.forename: Luigi
authors.initials: L
authors.lastname: Bartalena
authors.forename: Achille
authors.initials: A
authors.lastname: Venco
authors.forename: Walter
authors.initials: W
authors.lastname: Ageno
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001323:Autoantibodies / Q000097:blood; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000097:blood / Q000150:complications* / Q000276:immunology; D007453:Iodide Peroxidase / Q000276:immunology; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D012307:Risk Factors; D013954:Thyroglobulin / Q000276:immunology; D013963:Thyroid Hormones / Q000097:blood; D020246:Venous Thrombosis / Q000097:blood / Q000150:complications* / Q000209:etiology / Q000276:immunology
chemical_list: D001323:Autoantibodies; D013963:Thyroid Hormones; D013954:Thyroglobulin; D007453:Iodide Peroxidase