title: Convenient synthesis of photoaffinity probes and evaluation of their labeling abilities.
abstract: Convenient synthesis of a variety of photoaffinity probes was accomplished by utilizing our Ns strategy and novel resin. The synthetic probes were evaluated via the labeling ability with the preseniline 1 C-terminal fragments, which was identified as a therapeutic target for Alzheimer's disease.
authors.affiliation: School of Pharmaceutical Sciences, University of Shizuoka, Suruga-ku, Shizuoka 422-8526, Japan.
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Kan
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Kita
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Morohashi
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Tominari
authors.forename: Shinnosuke
authors.initials: S
authors.lastname: Hosoda
authors.forename: Taisuke
authors.initials: T
authors.lastname: Tomita
authors.forename: Hideaki
authors.initials: H
authors.lastname: Natsugari
authors.forename: Takeshi
authors.initials: T
authors.lastname: Iwatsubo
authors.forename: Tohru
authors.initials: T
authors.lastname: Fukuyama
mesh_terms: D015394:Molecular Structure; D019920:Photoaffinity Labels / Q000032:analysis / Q000138:chemical synthesis* / Q000737:chemistry*; D053764:Presenilin-1 / Q000737:chemistry*
chemical_list: D019920:Photoaffinity Labels; D053764:Presenilin-1