Evaluation of pentosan polysulfate sodium in the postoperative recovery from cranial cruciate injury in dogs: a randomized, placebo-controlled clinical trial.
OBJECTIVE
To evaluate the efficacy of pentosan polysulfate (PPS) for improving the recovery period and mitigate the progression of osteoarthritis (OA) of the canine stifle after extracapsular stabilization of cranial cruciate ligament (CCL) injuries.


METHODS
Randomized, blinded, placebo-controlled clinical trial.


METHODS
Dogs (n=40) with unilateral CCL instability.


METHODS
Each dog had an extracapsular stabilization of the stifle with or without partial meniscectomy. Dogs were divided into 4 groups based on preoperative radiographic assessment and whether a partial meniscectomy was performed. Dogs were randomly assigned to either (3 mg/kg) PPS or placebo treatment in each group, and then injected subcutaneously weekly for 4 weeks. Lameness, radiographic changes, biological marker concentration in blood and urine, and ground reaction forces (GRFs) were collected preoperatively, and at 6, 12, 24, and 48 weeks. Data were analyzed within and between groups using repeated measures ANOVA; P<.05 was considered significant.


RESULTS
No adverse reactions to PPS were reported. Thirty-nine dogs completed a minimum of 24-weeks follow-up and 33 dogs completed 48 weeks. All dogs clinically improved after surgery without differences in lameness score, vertical GRFs, or radiographic progression. Grouped and evaluated only by initial radiographic score, PPS-treated dogs improved significantly faster in braking GRFs than placebo-treated dogs. In dogs with partial meniscectomies, urine deoxypyridinoline, and serum carboxy-propeptide of type II collagen were significantly increased at 6 weeks in placebo-treated dogs compared with PPS-treated dogs.


CONCLUSIONS
PPS administered after stabilization of the cruciate deficient stifle may prove to be a useful adjunctive treatment option, although further studies are necessary to substantiate this claim.
Budsberg
Steven C
SC
Department of Small Animal Medicine and Surgery, University of Georgia College of Veterinary Medicine, Athens, GA 30602, USA. Budsberg@vet.uga.edu
Bergh
Mary Sarah
MS
Reynolds
Lisa R
LR
Streppa
Heather K
HK
D000818:Animals; D016118:Anterior Cruciate Ligament / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D000070598:Anterior Cruciate Ligament Injuries; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000627:therapeutic use*; D001182:Arthroscopy / Q000379:methods / Q000662:veterinary*; D004283:Dog Diseases / Q000097:blood / Q000517:prevention & control / Q000652:urine; D004285:Dogs / Q000293:injuries / Q000601:surgery*; D004311:Double-Blind Method; D005260:Female; D007267:Injections / Q000662:veterinary; D008297:Male; D020370:Osteoarthritis, Knee / Q000517:prevention & control / Q000662:veterinary; D010426:Pentosan Sulfuric Polyester / Q000008:administration & dosage / Q000627:therapeutic use*; D011182:Postoperative Care / Q000662:veterinary; D011183:Postoperative Complications / Q000517:prevention & control / Q000662:veterinary; D011446:Prospective Studies; D011859:Radiography; D016896:Treatment Outcome
D000894:Anti-Inflammatory Agents, Non-Steroidal; D010426:Pentosan Sulfuric Polyester