Two-locus epistasis with sexually antagonistic selection: a genetic Parrondo's paradox.
An example is provided where, with antagonistic selection and epistatic interaction of alleles at two loci, an autosomal allele can rise in frequency, persist in the population, and even continue to fixation, despite having an apparently lower average fitness than the alternative allele, in a process similar to Parrondo's paradox.
Reed
Floyd A
FA
Department of Biology, University of Maryland, College Park, Maryland 20742-5815, USA. freed@umd.edu
D000483:Alleles; D004843:Epistasis, Genetic; D005260:Female; D005716:Game Theory; D005787:Gene Frequency; D006801:Humans; D040582:Inheritance Patterns; D008297:Male; D008957:Models, Genetic; D012641:Selection, Genetic; D012737:Sex Factors