Hypolipidemic effect of dietary diacylglycerol oil in Sprague-Dawley rats fed a normal diet.
The present study compared the effects of dietary diacylglycerol (DG) and triacylglycerol (TG) oil on lipid metabolism in rats fed a 5% fat (AIN-76) diet for 6 weeks. The plasma and hepatic lipids, hepatic cholesterol-regulating enzyme activity, and hepatic and adipose tissue fatty acid metabolism enzyme activities were determined. Among plasma lipids, triglyceride, free fatty acid, and phospholipid concentrations were significantly lower in the DG group than in the TG group. A lower plasma TG level was accompanied by an increase in adipocyte lipoprotein lipase activity. The hepatic triglyceride level was significantly (P < .001) lowered in the DG group, which was attributable to an increased fatty acid oxidation enzyme (beta-oxidation) activity and a reduced fatty acid synthesis enzyme (glucose-6-phosphate dehydrogenase) activity. The plasma cholesterol concentration was significantly lower in the DG group and was accompanied by a lower hepatic 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity. The DG oil used in this study was beneficial for enhancing lipid metabolism with apparent hypolipidemic effects.
Kim
Hye-Jin
HJ
Department of Food Science and Nutrition, Kyungpook National University, Daegu, Republic of Korea.
Lee
Ki-Teak
KT
Lee
Mi-Kyung
MK
Jeon
Seon-Min
SM
Jung
Un Ju
UJ
Cho
Yun-Young
YY
Choi
Myung-Sook
MS
D017667:Adipocytes / Q000201:enzymology; D000818:Animals; D004032:Diet; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage*; D004075:Diglycerides / Q000008:administration & dosage*; D005227:Fatty Acids / Q000378:metabolism; D005230:Fatty Acids, Nonesterified / Q000097:blood; D006903:Hydroxymethylglutaryl CoA Reductases / Q000378:metabolism; D000960:Hypolipidemic Agents / Q000008:administration & dosage*; D008055:Lipids / Q000032:analysis / Q000097:blood; D008071:Lipoprotein Lipase / Q000378:metabolism; D008099:Liver / Q000737:chemistry / Q000201:enzymology; D008297:Male; D010084:Oxidation-Reduction; D010743:Phospholipids / Q000097:blood; D051381:Rats; D017207:Rats, Sprague-Dawley; D002785:Sterol O-Acyltransferase / Q000378:metabolism; D014280:Triglycerides / Q000008:administration & dosage / Q000097:blood
D004042:Dietary Fats, Unsaturated; D004075:Diglycerides; D005227:Fatty Acids; D005230:Fatty Acids, Nonesterified; D000960:Hypolipidemic Agents; D008055:Lipids; D010743:Phospholipids; D014280:Triglycerides; D006903:Hydroxymethylglutaryl CoA Reductases; D002785:Sterol O-Acyltransferase; D008071:Lipoprotein Lipase