Effect of simvastatin use on bone mineral density in women with type 2 diabetes.
OBJECTIVE
To attempt to clarify the effect of simvastatin, a widely used statin, on the bone mineral density in women with type 2 diabetes.


METHODS
We performed a cross-sectional, controlled study of 37 women with type 2 diabetes who were taking simvastatin. Each woman was matched with 2 control subjects who were closest in age, years since menopause (if applicable), and duration of diabetes on the date on which the examination was performed. We measured bone mineral density at the spine and the hip with a dual-energy xray absorptiometry scanner and compared bone density in the 2 study groups.


RESULTS
The mean bone mineral density values of patients in the simvastatin group were found to be slightly increased in comparison with those of the control group, both in the lumbar vertebrae and in the femoral neck, but these differences were not statistically significant (P>0.05).


CONCLUSIONS
In this cross-sectional study, we could not demonstrate a positive effect of long-term simvastatin treatment on bone mineral density in women with type 2 diabetes and hypercholesterolemia.
Uysal
Ali Riza
AR
Department of Endocrinology and Metabolism, Ankara University School of Medicine, Ankara, Turkey.
Delibasi
Tuncay
T
Erdogan
Murat F
MF
Kamel
Nuri
N
Baskal
Nilgun
N
Tonyukuk
Vedia
V
Corapcioglu
Demet
D
Güllü
Sevim
S
Erdogan
Gurbuz
G
D015502:Absorptiometry, Photon; D000368:Aged; D015519:Bone Density / Q000187:drug effects*; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy* / Q000378:metabolism; D005260:Female; D005500:Follow-Up Studies; D006621:Hip Joint / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D006937:Hypercholesterolemia / Q000188:drug therapy / Q000378:metabolism; D000960:Hypolipidemic Agents / Q000494:pharmacology / Q000627:therapeutic use; D008875:Middle Aged; D019821:Simvastatin / Q000494:pharmacology / Q000627:therapeutic use*; D013131:Spine / Q000187:drug effects / Q000378:metabolism; D013997:Time Factors
D000960:Hypolipidemic Agents; D019821:Simvastatin