title: Efficacy of fluoroquinolones against Leptospira interrogans in a hamster model.
abstract: Ciprofloxacin, gatifloxacin, and levofloxacin were evaluated for their abilities to prevent mortality in hamsters infected with a lethal inoculum of Leptospira interrogans serovar Portlandvere. Each agent produced a statistically significant survival advantage compared to no treatment and demonstrated survival similar to that seen with doxycycline therapy.
authors.affiliation: Infectious Disease Service, MCHE-MDI, Brooke Army Medical Center, 3851 Roger Brooke Drive, Fort Sam Houston, TX 78234, USA. matthew.griffith@amedd.army.mil
authors.forename: Matthew E
authors.initials: ME
authors.lastname: Griffith
authors.forename: James E
authors.initials: JE
authors.lastname: Moon
authors.forename: Erica N
authors.initials: EN
authors.lastname: Johnson
authors.forename: Kyra P
authors.initials: KP
authors.lastname: Clark
authors.forename: Joshua S
authors.initials: JS
authors.lastname: Hawley
authors.forename: Duane R
authors.initials: DR
authors.lastname: Hospenthal
authors.forename: Clinton K
authors.initials: CK
authors.lastname: Murray
mesh_terms: D000208:Acute Disease; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002939:Ciprofloxacin / Q000494:pharmacology; D006224:Cricetinae; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004318:Doxycycline / Q000494:pharmacology; D005260:Female; D024841:Fluoroquinolones / Q000494:pharmacology*; D000077734:Gatifloxacin; D007274:Injections, Intraperitoneal; D007921:Leptospira interrogans / Q000145:classification / Q000187:drug effects*; D007922:Leptospirosis / Q000188:drug therapy* / Q000401:mortality; D064704:Levofloxacin; D008647:Mesocricetus; D015242:Ofloxacin / Q000494:pharmacology; D012703:Serotyping; D016019:Survival Analysis
chemical_list: D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D002939:Ciprofloxacin; D064704:Levofloxacin; D015242:Ofloxacin; D000077734:Gatifloxacin; D004318:Doxycycline