[Identification of the origin of marker chromosome by comparative genomic hybridization].
OBJECTIVE
To identify the origin of the marker chromosome in a patient with chromosome aberration, and to provide the precise genetic diagnosis.


METHODS
Comparative genomic hybridization (CGH) and fluorescence in situ hybridization (FISH) were performed to detect the known small marker chromosome in this patient.


RESULTS
The small marker chromosome originated from chromosome 13 pter->q12.


CONCLUSIONS
CGH and FISH can be used to detect the small marker chromosome, which is convenient and quick in detecting the origin of small marker chromosome.
Zhou
Lu
L
National Laboratory of Medical Genetics of China, Xiangya Hospital, Central South University, Changsha, China.
Wu
Ling-Qian
LQ
Liang
De-Sheng
DS
Pan
Qian
Q
Long
Zhi-Gao
ZG
Dai
He-Ping
HP
Li
Juan
J
Cai
Fang
F
Xia
Kun
K
Xia
Jia-Hui
JH
D002869:Chromosome Aberrations; D002872:Chromosome Deletion; D002882:Chromosomes, Human, Pair 13 / Q000235:genetics*; D005260:Female; D015894:Genome, Human; D006801:Humans; D017404:In Situ Hybridization, Fluorescence / Q000379:methods*; D007621:Karyotyping; D009693:Nucleic Acid Hybridization / Q000379:methods*