A case-control association study between the GRID1 gene and schizophrenia in the Chinese Northern Han population.
The glutamatergic dysfunction hypothesis of schizophrenia implicates the genes involved in glutamatergic transmission as strong candidates for schizophrenia-susceptibility. Recent linkage and association studies have identified the glutamate receptor, ionotropic, delta 1 gene GRID1 on 10q22 as a strong candidate for schizophrenia. In this current association study, we genotyped five genetic variants within the GRID1 gene in 567 Chinese Han subjects recruited from Northeast of China (260 schizophrenics and 307 normal controls). Four SNPs, rs1902666 (P=0.024), rs2814351 (P=0.027), rs11591408 (P=0.0000107) and rs999383 (P=0.000093) were found to be significantly associated with schizophrenia. Haplotype analysis also revealed significance with global P values of 0.0081 and 0.00076 for SNPs 1-2 and SNPs 3-4-5 haplotypes, respectively. Our results strongly support previously reported association studies, implicating GRID1 in the etiology of schizophrenia.
Guo
Sheng-Zhen
SZ
Bio-X Center, Shanghai Jiao Tong University, Shanghai 200030, PR China.
Huang
Ke
K
Shi
Yong-Yong
YY
Tang
Wei
W
Zhou
Jian
J
Feng
Guo-Yin
GY
Zhu
Shao-Min
SM
Liu
Hui-Jun
HJ
Chen
Yi
Y
Sun
Xiao-Dong
XD
He
Lin
L
D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics*; D000328:Adult; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D002879:Chromosomes, Human, Pair 10; D005260:Female; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012559:Schizophrenia / Q000208:ethnology / Q000235:genetics*
D048868:Adaptor Proteins, Signal Transducing; C409587:GRAP2 protein, human; D005819:Genetic Markers