A combination of alleles 2 of interleukin (IL)-1A(-889) and IL-1B(+3954) is associated with lower gingival bleeding tendency in plaque-induced gingivitis in young adults of Arabic heritage.
The aim of this study was to investigate the possible association of a distinct combination of polymorphisms in the interleukin (IL)-1 gene cluster on gingival bleeding tendency in young adult Arabs with plaque-induced gingivitis. Fifty otherwise healthy, nonsmoking volunteers, 19-28 years of age, participated. Clinical examinations included periodontal probing depth, bleeding on probing, and plaque index. Probing was done with a pressure-controlled probe at about 1.27 MPa. Examinations were repeated after 2 and 4 weeks. Polymorphisms in the IL-1 gene cluster were assessed using a reverse hybridization assay. A subject carrying alleles 2 at IL-1A ( -889 ) and IL-1B ( +3954 ) was designated genotype-positive. Twenty-six subjects were genotype-positive (52%). A repeated measures two-level (occasion, subject) model of the proportion of sites bleeding on probing, which was adjusted for gender, average plaque index, probing depth, and calculus, revealed a significantly lower proportion of bleeding sites in genotype-positive subjects (estimate -0.050, standard error 0.025, p < 0.05). Biserial correlations of bleeding proportions were high (0.71-0.78), confirming the steady-state plaque environment. It was concluded that inflammatory responses to dental plaque were considerably dampened in genotype-positive, nonsmoking young adults of Arabic heritage.
Müller
H P
HP
Faculty of Dentistry, Kuwait University, Safat, Kuwait. hp.muller@hsc.edu.kw
Barrieshi-Nusair
K M
KM
D000328:Adult; D000483:Alleles; D018912:Arabs / Q000235:genetics*; D003728:Dental Calculus / Q000150:complications; D003773:Dental Plaque / Q000150:complications*; D003774:Dental Plaque Index; D005260:Female; D005838:Genotype; D005884:Gingival Hemorrhage / Q000209:etiology* / Q000276:immunology; D005891:Gingivitis / Q000209:etiology* / Q000276:immunology; D006801:Humans; D053582:Interleukin-1alpha / Q000235:genetics*; D053583:Interleukin-1beta / Q000235:genetics*; D008297:Male; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000209:etiology / Q000276:immunology; D011110:Polymorphism, Genetic / Q000235:genetics*; D012737:Sex Factors
D053582:Interleukin-1alpha; D053583:Interleukin-1beta