[Kidney as a regulating organ for calcium and phosphate homeostasis].
Kidney is a central effector organ on calcium (Ca) and phosphate (P) homeostasis. Their homeostasis are mainly preserved by renal reabsorption and excretion, which often regulated through common hormonal signals, parathyroid hormone (PTH), vitamin D, and calcitonin. The hormones also involves phosphatonins as a circulating factor with potent phosphaturic activity and the key phosphatonin appears to be a fibroblast growth factor (FGF) 23. FGF23 is associated with vitamin D metabolism as well as tubular phosphate excretion. Moreover, recent study using animal models revealed the task of klotho protein, which gene functions as an aging-suppressor gene, for the regulation of FGF23 signaling, Ca(2+) absorption and vitamin D modulation in the kidney.
Honda
Hirokazu
H
Showa University School of Medicine, Department of Nephrology, Japan.
Hosaka
Nozomu
N
Akizawa
Tadao
T
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000502:physiology; D005966:Glucuronidase / Q000235:genetics; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D007668:Kidney / Q000502:physiology*; D000090265:Klotho Proteins; D010281:Parathyroid Hormone; D010710:Phosphates / Q000378:metabolism*; D014807:Vitamin D / Q000378:metabolism
C000717427:FGF23 protein, human; D010281:Parathyroid Hormone; D010710:Phosphates; D014807:Vitamin D; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23; D005966:Glucuronidase; D000090265:Klotho Proteins; D002118:Calcium