title: Deep grey matter "black T2" on 3 tesla magnetic resonance imaging correlates with disability in multiple sclerosis.
abstract: T2 hypointensity (black T2, BT2) in the deep grey matter of multiple sclerosis (MS) patients correlate weakly with disability at 1.5 T. BT2 is likely to be caused by abnormal iron deposition. We compared the correlation between disability and deep grey matter BT2 measured on 3 T MRI and on 1.5 T MRI in 17 MS patients. We observed a significant correlation between expanded disability status scale and signal intensity on 3 T MRI in the globus pallidus and the caudate nucleus (r = -0.5, P < 0.05). BT2 at 3 T may be a useful MRI measure associated with disability in MS and warrants further study.
authors.affiliation: Department of Radiology, University of Calgary, Calgary, Canada.
authors.forename: Y
authors.initials: Y
authors.lastname: Zhang
authors.forename: R  K
authors.initials: R
authors.lastname: Zabad
authors.forename: X
authors.initials: X
authors.lastname: Wei
authors.forename: L  M
authors.initials: L
authors.lastname: Metz
authors.forename: M  D
authors.initials: M
authors.lastname: Hill
authors.forename: J  R
authors.initials: J
authors.lastname: Mitchell
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000378:metabolism; D001921:Brain / Q000378:metabolism / Q000473:pathology*; D002421:Caudate Nucleus / Q000378:metabolism / Q000473:pathology; D004185:Disability Evaluation; D005260:Female; D005917:Globus Pallidus / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007501:Iron / Q000378:metabolism; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000473:pathology* / Q000503:physiopathology*; D011699:Putamen / Q000378:metabolism / Q000473:pathology; D012012:Red Nucleus / Q000378:metabolism / Q000473:pathology; D013378:Substantia Nigra / Q000378:metabolism / Q000473:pathology; D013788:Thalamus / Q000378:metabolism / Q000473:pathology
chemical_list: D015415:Biomarkers; D007501:Iron