title: [Evaluation of the performance of immunological parameters as indicators for clinical progression of chronic HTLV-1 infection].
abstract: This study evaluated the performance of single and combined laboratory parameters, B-lymphocyte percentages (%LB), T/B cell ratio and %CD8+HLA-DR+/CD8+, to differentiate asymptomatic cases (AS) from HAM/TSP patients (HT) within a population of HTLV-1 seropositive cases. Percentage indices demonstrated that each parameter alone presented moderate performance, with co-negativity of 83 and 91% for %LB and T/B cell ratio, respectively, and co-positivity of 78% for %CD8+HLA-DR+/CD8+. Combined analysis (%CD8+HLA-DR+/CD8+ and T/B cell ratio) did not show any substantial performance enhancement (co-positivity = 75% and co-negativity = 74%). Likelihood ratio analysis using different value ranges for the separate parameters revealed that HTLV-1 seropositive cases with %LB<7%, T/B cell ratio>11 and %CD8+HLA-DR+/CD8+>70% would have, respectively, 11, 19 and 10 times greater chance of belonging to the HT group. Therefore, use of these phenotypic indicators as complementary laboratory methods for monitoring the clinical progression of chronic HTLV-1 infection is recommended.
authors.affiliation: Centro de Pesquisas René Rachou, Fundação Oswaldo Cruz, Belo Horizonte, MG.
authors.forename: Jordana Grazziela Alves
authors.initials: JG
authors.lastname: Coelho-dos-Reis
authors.forename: Roberta Dias Rodrigues
authors.initials: RD
authors.lastname: Rocha
authors.forename: Gustavo Eustáquio Alvim
authors.initials: GE
authors.lastname: Brito-Melo
authors.forename: João Gabriel
authors.initials: JG
authors.lastname: Ribas
authors.forename: Anna Bárbara de Freitas
authors.initials: AB
authors.lastname: Carneiro-Proietti
authors.forename: Bernadete
authors.initials: B
authors.lastname: Catalan-Soares
authors.forename: Edel Figueiredo
authors.initials: EF
authors.lastname: Barbosa-Stancioli
authors.forename: Olindo Assis
authors.initials: OA
authors.lastname: Martins-Filho
mesh_terms: D001402:B-Lymphocytes / Q000276:immunology*; D015415:Biomarkers; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D002908:Chronic Disease; D018450:Disease Progression; D006684:HLA-DR Antigens / Q000276:immunology*; D015490:HTLV-I Infections / Q000097:blood / Q000276:immunology*; D006801:Humans; D018655:Lymphocyte Count; D015493:Paraparesis, Tropical Spastic / Q000097:blood / Q000276:immunology; D010641:Phenotype; D011237:Predictive Value of Tests; D012372:ROC Curve; D015203:Reproducibility of Results
chemical_list: D015415:Biomarkers; D006684:HLA-DR Antigens