Anti-cytokine autoantibodies are ubiquitous in healthy individuals.
Anti-cytokine autoantibodies in healthy individuals have been widely reported but the occurrence is variable and inconstant. We hypothesized that cytokine-binding in vivo may explain their variable and infrequent detection. Therefore, we focused on the detection of the cytokine-autoantibody complexes and found that anti-cytokine autoantibody to IL-2, IL-8, tumor necrosis factor-alpha, vascular endothelial growth factor and granulocyte-colony stimulating factor were present in all 15 individuals evaluated, while those to IL-3, osteopontin and macrophage-colony stimulating factor were not detected in anyone. Autoantibodies against IL-4, IL-6, IL-10, and interferon-gamma were variously detected. Thus, we discovered that anti-cytokine autoantibodies to multiple cytokines are ubiquitous in healthy individuals.
Watanabe
Masato
M
Bioscience Medical Research Center, Niigata University Medical and Dental Hospital, Niigata 951-8520, Japan.
Uchida
Kanji
K
Nakagaki
Kazuhide
K
Kanazawa
Hiroko
H
Trapnell
Bruce C
BC
Hoshino
Yoshihiko
Y
Kagamu
Hiroshi
H
Yoshizawa
Hirohisa
H
Keicho
Naoto
N
Goto
Hajime
H
Nakata
Koh
K
D000328:Adult; D000918:Antibody Specificity / Q000276:immunology; D001323:Autoantibodies / Q000097:blood* / Q000276:immunology*; D016207:Cytokines / Q000097:blood / Q000276:immunology*; D005260:Female; D006262:Health; D006801:Humans; D008024:Ligands; D008297:Male; D008875:Middle Aged; D042442:Vascular Endothelial Growth Factors / Q000276:immunology
D001323:Autoantibodies; D016207:Cytokines; D008024:Ligands; D042442:Vascular Endothelial Growth Factors