title: 5T4 oncotrophoblast glycoprotein: janus molecule in life and a novel potential target against tumors.
abstract: 5T4 oncotrophoblast glycoprotein is a transmembrane protein expressed on the embryonic tissue and various malignant tumor cell surfaces. It plays a vital role in the multiple biological and pathological processes including massive cellular migration during the embryogenesis, cell invasion associated with implantation, and neoplastic metastasis in the progression of tumorigenesis. Its restricted profile of expression stratifies criteria of tumor-associated antigen and makes it a new promising candidate for immunotherapy for cancer. Hence, illustrating this molecular function is necessary for discovering the principle of the tumor diffusion and aggravation and is helpful for developing novel and effective strategies of cancer therapy.
authors.affiliation: Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhao
authors.forename: Yuxia
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D000951:Antigens, Neoplasm / Q000276:immunology / Q000378:metabolism*; D000970:Antineoplastic Agents / Q000627:therapeutic use; D019496:Cancer Vaccines / Q000627:therapeutic use; D002465:Cell Movement; D002471:Cell Transformation, Neoplastic / Q000276:immunology / Q000378:metabolism*; D047108:Embryonic Development / Q000502:physiology; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D000922:Immunotoxins / Q000627:therapeutic use; D016246:Lymphocytes, Tumor-Infiltrating / Q000378:metabolism; D008562:Membrane Glycoproteins / Q000276:immunology / Q000378:metabolism*; D009361:Neoplasm Invasiveness; D009369:Neoplasms / Q000276:immunology / Q000378:metabolism* / Q000473:pathology / Q000628:therapy; D019444:Vaccines, DNA
chemical_list: D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D000970:Antineoplastic Agents; D019496:Cancer Vaccines; D000922:Immunotoxins; D008562:Membrane Glycoproteins; C504058:TroVax; D019444:Vaccines, DNA; C063709:trophoblastic glycoprotein 5T4, human