title: Flavonoids isolated from Draconis Resina.
abstract: One new chalcone, 4,6-dihydroxy-2-methoxy-3-methyldihydrochalcone (4), together with four known compounds, dammaradienol (1), (-)-5-methoxyflavan-7-ol (2), 5-methoxy-6-methyl-2-phenyl-7H-chromen-7-one (3), and dracorhodin (5), were isolated from Draconis Resina. The structures of these compounds were determined by spectral methods. Among these five compounds, compounds 1, 2, and 3 exhibited cytotoxicity against KB and HepG2 cells.
authors.affiliation: National Research Institute of Chinese Medicine, Taipei, Taiwan, Republic of China.
authors.forename: Chien-Chang
authors.initials: CC
authors.lastname: Shen
authors.forename: Show-Yinn
authors.initials: SY
authors.lastname: Tsai
authors.forename: Sai-Luh
authors.initials: SL
authors.lastname: Wei
authors.forename: Shr-Ting
authors.initials: ST
authors.lastname: Wang
authors.forename: Bor-Jinn
authors.initials: BJ
authors.lastname: Shieh
authors.forename: Chien-Chih
authors.initials: CC
authors.lastname: Chen
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D047188:Chalcones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D031409:Dracaena / Q000737:chemistry*; D004365:Drugs, Chinese Herbal / Q000737:chemistry; D006801:Humans; D013058:Mass Spectrometry; D019906:Nuclear Magnetic Resonance, Biomolecular; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000970:Antineoplastic Agents; D047188:Chalcones; D004365:Drugs, Chinese Herbal