title: Oligosaccharide synthesis in microreactors.
abstract: Described is the combination of microreactors and fluorous phase chemistry to assemble oligosaccharides. The synthesis of a beta-(1-->6) linked D-glucopyranoside homotetramer serves to illustrate this approach. Glycosylations employing a Fmoc-protected glucosyl phosphate building block were performed in a silicon-based micro-structured device to optimize reaction conditions and for reaction scale-up. A perfluorinated linker at the reducing end of the oligosaccharides allowed for purification by fluorous solid-phase extraction (FSPE) and further functionalization.
authors.affiliation: Laboratory of Organic Chemistry, Swiss Federal Institute of Technology ETH Zürich, Zürich, Switzerland.
authors.forename: Frédéric R
authors.initials: FR
authors.lastname: Carrel
authors.forename: Karolin
authors.initials: K
authors.lastname: Geyer
authors.forename: Jeroen D C
authors.initials: JD
authors.lastname: Codée
authors.forename: Peter H
authors.initials: PH
authors.lastname: Seeberger