Role of the toll-like receptor 4 polymorphism Asp299Gly in longevity and myocardial infarction in German men.
In a previous study on Sicilian men, an association of the functional polymorphism Asp299Gly in the TLR4 gene was reported with longevity and a reduced risk of myocardial infarction (MI). Here, we sought to confirm the findings in our extensive collection of 273 long-lived men (95-107 years), 606 male early-onset MI patients and 594 appropriate controls from Germany. Despite sufficient statistical power to replicate the findings observed in the South Italians, our results rule out a noteworthy influence of the TLR4 polymorphism upon human longevity or MI in German men. Therefore, the previously described associations in Sicilians might reflect either population-specific or potentially false-positive results.
Nebel
Almut
A
Institute of Clinical Molecular Biology, Christian-Albrechts-University Kiel, Germany.
Flachsbart
Friederike
F
Schäfer
Arne
A
Nothnagel
Michael
M
Nikolaus
Susanna
S
Mokhtari
Nour Eddine El
NE
Schreiber
Stefan
S
D000328:Adult; D000368:Aged; D019943:Amino Acid Substitution; D001224:Aspartic Acid / Q000737:chemistry / Q000235:genetics; D005858:Germany; D005998:Glycine / Q000737:chemistry / Q000235:genetics; D006801:Humans; D008136:Longevity / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000235:genetics*; D011110:Polymorphism, Genetic; D051197:Toll-Like Receptor 4 / Q000235:genetics*
C495345:TLR4 protein, human; D051197:Toll-Like Receptor 4; D001224:Aspartic Acid; D005998:Glycine