title: Assessment of global and regional left ventricular function using 64-slice multislice computed tomography and 2D echocardiography: a comparison with cardiac magnetic resonance.
abstract: OBJECTIVE
  To compare the assessment of global and regional left ventricular (LV) function using 64-slice multislice computed tomography (MSCT), 2D echocardiography (2DE) and cardiac magnetic resonance (CMR).
  
  
  METHODS
  Thirty-two consecutive patients (mean age, 56.5+/-9.7 years) referred for evaluation of coronary artery using 64-slice MSCT also underwent 2DE and CMR within 48h. The global left ventricular function which include left ventricular ejection fraction (LVEF), left ventricular end diastolic volume (LVdV) and left ventricular end systolic volume (LVsV) were determine using the three modalities. Regional wall motion (RWM) was assessed visually in all three modalities. The CMR served as the gold standard for the comparison between 64-slice MSCT with CMR and 2DE with CMR. Statistical analysis included Pearson correlation coefficient, Bland-Altman plots and kappa-statistics.
  
  
  RESULTS
  The 64-slice MSCT agreed well with CMR for assessment of LVEF (r=0.92; p<0.0001), LVdV (r=0.98; p<0.0001) and LVsV (r=0.98; p<0.0001). In comparison with 64-slice MSCT, 2DE showed moderate correlation with CMR for the assessment of LVEF (r=0.84; p<0.0001), LVdV (r=0.83; p<0.0001) and LVsV (r=0.80; p<0.0001). However in RWM analysis, 2DE showed better accuracy than 64-slice MSCT (94.3% versus 82.4%) and closer agreement (kappa=0.89 versus 0.63) with CMR.
  
  
  CONCLUSIONS
  64-Slice MSCT correlates strongly with CMR in global LV function however in regional LV function 2DE showed better agreement with CMR than 64-slice MSCT.
authors.affiliation: Faculty of Medicine, University Malaysia Sarawak, Department of Cardiology, Sarawak General Hospital, Malaysia. rannuar@fmhs.unimas.my
authors.forename: Bin Rapaee
authors.initials: BR
authors.lastname: Annuar
authors.forename: Chee Khoon
authors.initials: CK
authors.lastname: Liew
authors.forename: Sze Piaw
authors.initials: SP
authors.lastname: Chin
authors.forename: Tiong Kiam
authors.initials: TK
authors.lastname: Ong
authors.forename: M Tobias
authors.initials: MT
authors.lastname: Seyfarth
authors.forename: Wei Ling
authors.initials: WL
authors.lastname: Chan
authors.forename: Yean Yip
authors.initials: YY
authors.lastname: Fong
authors.forename: Choon Kiat
authors.initials: CK
authors.lastname: Ang
authors.forename: Naing
authors.initials: N
authors.lastname: Lin
authors.forename: Houng Bang
authors.initials: HB
authors.lastname: Liew
authors.forename: Kui Hian
authors.initials: KH
authors.lastname: Sim
mesh_terms: D016009:Chi-Square Distribution; D004452:Echocardiography / Q000379:methods*; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D014057:Tomography, X-Ray Computed / Q000379:methods*; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis*