Synthesis of isomeric, oxathiolone fused chalcones, and comparison of their activity toward various microorganisms and human cancer cells line.
Isomeric oxathiolone fused chalcones were prepared by condensation of appropriate acetylbenzo[1,3]oxathiol-2-ones with benzaldehydes under acidic conditions. The synthesized compounds were screened for cytotoxic activity using HeLa cells, as well as for antibacterial activity against Micrococcus luteus, Staphylococcus aureus, Salmonella typhimurium, Escherichia coli, Proteus vulgaris, antifungal activity against Candida albicans, and tuberculostatic activity against Mycobacterium tuberculosis H(37)Rv and Mycobacterium kansasii strains.
Konieczny
Marek Tadeusz
MT
Department of Organic Chemistry, Medical University of Gdańsk, 80-416 Gdańsk, Poland. markon@amg.gda.pl
Konieczny
Wojciech
W
Sabisz
Michał
M
Skladanowski
Andrzej
A
Wakieć
Roland
R
Augustynowicz-Kopeć
Ewa
E
Zwolska
Zofia
Z
D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D000995:Antitubercular Agents / Q000138:chemical synthesis / Q000494:pharmacology; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D047188:Chalcones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D007536:Isomerism; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D013778:Tetrazolium Salts; D013844:Thiazoles
D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D000995:Antitubercular Agents; D019086:Bridged Bicyclo Compounds, Heterocyclic; D047188:Chalcones; D013778:Tetrazolium Salts; D013844:Thiazoles; C022616:thiazolyl blue