Regulatory T-cell immunity in atherosclerosis.
Atherosclerosis is an inflammatory disease of the arterial wall where both innate and adaptive T-cell-driven immunoinflammatory responses contribute to disease development. Recent studies from several groups suggest that subtypes of T cells, called regulatory T cells, previously shown to maintain immunologic tolerance, control the development and progression of atherosclerosis. Here, we summarize the current knowledge on the regulatory T-cell response in the context of atherosclerosis and the accumulating evidence for its central role in counteracting disease initiation and progression.
Mallat
Ziad
Z
Institut National de la Santé et de la Recherche Médicale, Inserm U689, Cardiovascular Research Center Lariboisière, and University Paris 7, Paris, France. mallat@larib.inserm.fr
Ait-Oufella
Hafid
H
Tedgui
Alain
A
D000818:Animals; D015703:Antigens, CD; D017209:Apoptosis; D050197:Atherosclerosis / Q000276:immunology* / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use; D051379:Mice; D010587:Phagocytosis; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D015703:Antigens, CD; D007155:Immunologic Factors