[Effects of vitamin D on non-classical target organs and survival].
Impaired activation of vitamin D in renal failure results in bone and mineral abnormalities, and causes renal osteodystrophy or chronic kidney disease mineral and bone disorder (CKD-MBD). Recent studies suggest that deficiency of active vitamin D is also involved in abnormalities in blood pressure, cardiac hypertrophy, atherosclerosis, glucose intolerance and immune dysfunction that are known as complications of uremia. This article reviews these extra-renal actions of vitamin D and its impact on survival of dialysis patients.
Shoji
Tetsuo
T
Osaka City University, Graduate School of Medicine, Department of Metabolism Endocrinology and Molecular Medicine, Japan.
Nishizawa
Yoshiki
Y
D002114:Calcinosis / Q000209:etiology; D042783:Endothelial Cells / Q000502:physiology; D006801:Humans; D007109:Immunity / Q000502:physiology; D007249:Inflammation / Q000503:physiopathology; D009026:Mortality; D011379:Prognosis; D014807:Vitamin D / Q000502:physiology*
D014807:Vitamin D