title: Probing lateral diffusion in lipid membranes on nanoscale by PFG NMR with high gradient strength.
abstract: This work demonstrates the feasibility of noninvasive studies of diffusion on a submicrometer length scale in aligned model lipid membranes using pulsed field gradient nuclear magnetic resonance with ultrahigh (up to 35 T/m) gradient strength. Application of such gradients allows the use of sufficiently small diffusion times under conditions of narrow-pulse approximation. As a result, monitoring anomalous or restricted diffusion in lipid membranes on a length scale in the range of 100 nm becomes possible. The ability to study diffusion in lipid membranes on this length scale is very important because it is comparable with the size of biologically relevant domains (i.e., rafts), which are believed to exist in biomembranes.
authors.affiliation: Fakultät für Physik und Geowissenschaften, Universität Leipzig, 04103 Leipzig, Germany.
authors.forename: Konstantin
authors.initials: K
authors.lastname: Ulrich
authors.forename: Monica
authors.initials: M
authors.lastname: Sanders
authors.forename: Sergey
authors.initials: S
authors.lastname: Vasenkov
mesh_terms: D004058:Diffusion; D005240:Feasibility Studies; D008051:Lipid Bilayers / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008280:Magnetics; D008563:Membrane Lipids / Q000737:chemistry; D021962:Membrane Microdomains / Q000737:chemistry; D008954:Models, Biological
chemical_list: D008051:Lipid Bilayers; D008563:Membrane Lipids