Interleukin-4 depresses levels of transcripts for acid-sphingomyelinase and glucocerebrosidase and the amount of ceramide in acetone-wounded epidermis, as demonstrated in a living skin equivalent.
Hatano
Yutaka
Y
Katagiri
Kazumoto
K
Arakawa
Shoko
S
Fujiwara
Sakuhei
S
D000096:Acetone / Q000494:pharmacology; D002518:Ceramides / Q000378:metabolism*; D004817:Epidermis / Q000187:drug effects / Q000378:metabolism*; D005962:Glucosylceramidase / Q000037:antagonists & inhibitors / Q000378:metabolism; D006801:Humans; D015847:Interleukin-4 / Q000494:pharmacology*; D012879:Skin Physiological Phenomena / Q000187:drug effects*; D017768:Skin, Artificial; D013108:Sphingomyelin Phosphodiesterase / Q000037:antagonists & inhibitors / Q000378:metabolism; D014867:Water / Q000378:metabolism; D014945:Wound Healing / Q000187:drug effects*
D002518:Ceramides; D014867:Water; D000096:Acetone; D015847:Interleukin-4; D013108:Sphingomyelin Phosphodiesterase; D005962:Glucosylceramidase