Perilimbal conjunctival pigmentation in Chinese patients with vernal keratoconjunctivitis.
OBJECTIVE
To document the disease spectrum and evaluate the presence of perilimbal conjunctival pigmentation in Chinese patients with vernal keratoconjunctivitis (VKC).


METHODS
A case-control study was conducted between November 2004 and July 2005. Patients aged 18 or younger with VKC and age-matched children attending our eye clinic for refractive or orthoptic problems were recruited and compared. Detailed slit-lamp examination was performed noting in particular the presence of perilimbal conjunctival pigmentation, the severity of papillary reaction, and corneal complications of VKC.


RESULTS
A total of 19 patients and 23 controls were evaluated. The presence of bilateral large tarsal or limbal papillae and epithelial defect were significantly associated with symptoms severity (Fisher's exact test, P=0.015 and P=0.035 respectively). All VKC patients were found to have perilimbal conjunctival pigmentation in at least one eye. There was a significant correlation in the colour and density of pigments between the two eyes (Sperman's rho=0.93, P<0.001). None of the controls was found to have such perilimbal conjunctival pigmentation (Fisher's exact test, P<0.001).


CONCLUSIONS
The presence of perilimbal conjunctival pigmentation appears to be a consistent clinical finding in Chinese patients with VKC and may be a useful diagnostic sign for patients with subtle signs or symptoms.
Luk
F O J
FO
Department of Ophthalmology & Visual Science, The Chinese University of Hong Kong, Hong Kong SAR, People's Republic of China.
Wong
V W Y
VW
Rao
S K
SK
Lam
D S C
DS
D000293:Adolescent; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D003229:Conjunctival Diseases / Q000209:etiology / Q000473:pathology; D003233:Conjunctivitis, Allergic / Q000150:complications* / Q000175:diagnosis; D005260:Female; D006801:Humans; D017495:Hyperpigmentation / Q000209:etiology* / Q000473:pathology; D008297:Male