title: C-type natriuretic peptide in individuals with normal left ventricular systolic function.
abstract: OBJECTIVE
  The objective of this study was to evaluate production or release of CNP in individuals without CHF.
  
  
  METHODS
  Nineteen patients with symptomatic paroxysmal supraventricular tachycardia (PSVT) and normal left ventricular systolic function were enrolled into the study. Blood samples were collected from the coronary sinus (CS), the femoral artery (FA), and the peripheral vein (PV) before pacing, after rapid RA pacing, and post electrophysiological study (EPS) and/or radiofrequency (RF) ablation.
  
  
  RESULTS
  The CNP level in the CS, compared to FA and PV, was significantly higher before pacing (CS, 3.2+/-0.8; FA, 2.6+/-0.7; PV, 2.5+/-0.5 pg/ml; CS vs. either FA or PV, both p<0.001), after the pacing (CS, 3.2+/-1.3; FA, 2.4+/-0.6 pg/ml; p=0.004), and post the EPS and/or RF ablation (CS, 3.1+/-0.7; FA, 2.6+/-0.9; PV, 2.5+/-0.8 pg/ml; CS vs. either FA or PV, both p<0.01).
  
  
  CONCLUSIONS
  The myocardium regularly produces or releases CNP in patients with normal LV systolic function. Brief periods of rapid RA pacing, PSVT, or EPS does not change the production and/or release.
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Mackay Memorial Hospital, Mackay Medicine, Nursing, and Management College, and National Yang-Ming University, School of Medicine, Taipei, Taiwan.
authors.forename: Jen-Yuan
authors.initials: JY
authors.lastname: Kuo
authors.forename: Hung-I
authors.initials: HI
authors.lastname: Yeh
authors.forename: Sheng-Hsiung
authors.initials: SH
authors.lastname: Chang
authors.forename: Bing-Fu
authors.initials: BF
authors.lastname: Shih
authors.forename: An-Mei
authors.initials: AM
authors.lastname: Wang
authors.forename: Chun-Yen
authors.initials: CY
authors.lastname: Chen
authors.forename: Charles Jia-Yin
authors.initials: CJ
authors.lastname: Hou
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D017115:Catheter Ablation; D022062:Electrophysiologic Techniques, Cardiac; D005260:Female; D005263:Femoral Artery; D006801:Humans; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism*; D020098:Natriuretic Peptide, C-Type / Q000097:blood*; D013599:Systole; D013614:Tachycardia, Paroxysmal / Q000097:blood* / Q000503:physiopathology / Q000601:surgery; D013617:Tachycardia, Supraventricular / Q000097:blood* / Q000503:physiopathology / Q000601:surgery; D014680:Veins; D016277:Ventricular Function, Left
chemical_list: D015415:Biomarkers; D020098:Natriuretic Peptide, C-Type