title: Acute Marchiafava-Bignami disease: diffusion-weighted MRI in cortical and callosal involvement.
abstract: Marchiafava-Bignami disease (MBD) is a fatal disorder characterized by demyelination of the corpus callosum. MRI, suggestive of corpus callosum demyelination with associated white matter involvement in both cerebral hemispheres, indicates a diagnosis of MBD. In this case, MR diffusion-weighted findings taken at an acute stage of MBD revealed lesions not only in the corpus callosum but also in the cerebral cortex. Lower apparent diffusion coefficient values of the corpus callosum and cortical lesions were associated with poor clinical outcome.
authors.affiliation: Department of Radiology, St Vincent Hospital, The Catholic University of Korea, 93-6 Ji-Dong, Paldal-Gu, Suwon-Si, Gyenggi-Do, Korea. Ihn@catholic.ac.kr
authors.forename: Yon Kwon
authors.initials: YK
authors.lastname: Ihn
authors.forename: Seong Su
authors.initials: SS
authors.lastname: Hwang
authors.forename: Young Ha
authors.initials: YH
authors.lastname: Park
mesh_terms: D000437:Alcoholism / Q000150:complications; D001921:Brain / Q000473:pathology*; D003337:Corpus Callosum / Q000473:pathology*; D003711:Demyelinating Diseases / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged