Selective inhibition of porcine endogenous retrovirus replication in human cells by acyclic nucleoside phosphonates.
Several anti-human immunodeficiency virus type 1 reverse transcriptase inhibitors were evaluated for their antiviral activities against porcine endogenous retrovirus in human cells. Among the test compounds, zidovudine was found to be the most active. The order of potency was zidovudine > phosphonylmethoxyethoxydiaminopyrimidine = phosphonylmethoxypropyldiaminopurine > tenofovir > or = adefovir > stavudine.
Shi
Minyi
M
Frontier Science Research Center, Kagoshima University, Kagoshima 890-8544, Japan.
Wang
Xin
X
De Clercq
Erik
E
Takao
Sonshin
S
Baba
Masanori
M
D000225:Adenine / Q000031:analogs & derivatives / Q000494:pharmacology; D000595:Amino Acid Sequence; D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D002384:Catalysis; D002460:Cell Line; D004305:Dose-Response Relationship, Drug; D020077:Endogenous Retroviruses / Q000187:drug effects* / Q000201:enzymology / Q000502:physiology; D015497:HIV-1 / Q000187:drug effects / Q000201:enzymology; D006801:Humans; D007668:Kidney / Q000166:cytology; D008969:Molecular Sequence Data; D063065:Organophosphonates / Q000737:chemistry / Q000494:pharmacology*; D016133:Polymerase Chain Reaction; D017434:Protein Structure, Tertiary; D018894:Reverse Transcriptase Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D018119:Stavudine / Q000494:pharmacology; D013552:Swine; D013556:Swine, Miniature; D000068698:Tenofovir; D014779:Virus Replication / Q000187:drug effects*; D015215:Zidovudine / Q000494:pharmacology
D000998:Antiviral Agents; D063065:Organophosphonates; D018894:Reverse Transcriptase Inhibitors; D015215:Zidovudine; C053001:adefovir; D000068698:Tenofovir; D018119:Stavudine; D000225:Adenine