title: Relationship between insulin resistance and serum levels of adiponectin and resistin with childhood obesity.
abstract: OBJECTIVE
  The aim is to study the relationship between insulin resistance and serum adiponectin and resistin in obese children.
  
  
  METHODS
  A total 113 obese and 37 nonobese children were enrolled and serum adiponectin and resistin were measured.
  
  
  RESULTS
  Compared with controls, higher insulin resistance by homeostasis model (HOMA-IR) and lower whole body insulin resistance index (WBISI)were found in obese children (all P <0.05). The adiponectin levels in obese children and controls were 3.63 and 5.79 microg/L with a significant difference (P<0.001) while the difference of resistin levels was not significant (P = 0.948). Significant correlations between insulin resistance parameter and age,sexual development, BMI, serum triglyceride, ApoB, LDL-cholesterol, HDL-cholesterol, alanine aminotransferase, uric acid, or adiponectin levels (all P <0.05) were noted. Stepwise multiple regression analysis showed that BMI and adiponectin levels were independent determinants of WBISI.
  
  
  CONCLUSIONS
  These results suggest that adiponectin may play a protective role in obese children through decreasing insulin resistance.
authors.affiliation: Children's Hospital of Zhejiang University School of Medicine, 57 Zhugan Xiang, Hangzhou 310 003, China.
authors.forename: Chao Chun
authors.initials: CC
authors.lastname: Zou
authors.forename: Li
authors.initials: L
authors.lastname: Liang
authors.forename: Fang
authors.initials: F
authors.lastname: Hong
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000293:Adolescent; D016022:Case-Control Studies; D002648:Child; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D009765:Obesity / Q000453:epidemiology / Q000378:metabolism* / Q000503:physiopathology; D052243:Resistin / Q000097:blood*; D012307:Risk Factors
chemical_list: D052242:Adiponectin; D052243:Resistin