title: Ultrasensitive p24 antigen assay for diagnosis of perinatal human immunodeficiency virus type 1 infection.
abstract: We evaluated an ultrasensitive p24 antigen enzyme immunosorbent assay on 802 plasma specimens from 582 infants and children of 0 to 180 days of age. Overall sensitivity and specificity were 91.7% and 98.5%, respectively. After exclusion of infants of less than 7 days of age, the sensitivity and specificity were 93.7% and 98.3%, respectively.
authors.affiliation: University of North Carolina at Chapel Hill, Department of Microbiology and Immunology, Chapel Hill, North Carolina, USA. fiscussa@med.unc.edu
authors.forename: Susan A
authors.initials: SA
authors.lastname: Fiscus
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Wiener
authors.forename: Elaine J
authors.initials: EJ
authors.lastname: Abrams
authors.forename: Marc
authors.initials: M
authors.lastname: Bulterys
authors.forename: Ada
authors.initials: A
authors.lastname: Cachafeiro
authors.forename: Richard A
authors.initials: RA
authors.lastname: Respess
mesh_terms: D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods*; D016655:HIV Core Protein p24 / Q000032:analysis* / Q000097:blood*; D015658:HIV Infections / Q000175:diagnosis* / Q000453:epidemiology; D015497:HIV-1; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000175:diagnosis* / Q000453:epidemiology; D012680:Sensitivity and Specificity; D014481:United States
chemical_list: D016655:HIV Core Protein p24