title: Registration and analysis of bioelectric activity of sensory-motor cortex during the electrical stimulation of nucleus caudate in rats.
abstract: OBJECTIVE
  The caudate circuit takes part in cognitive control of motor activity. The purpose of the present work was registration and analysis of basic bioelectrical activity of ventral and dorsal sensory-motor cortex and nucleus caudate, study of the changes in EEG after nucleus caudate electrical stimulation and to identify of threshold level of electrical stimuli responsible for changes of electrical activity in registered brain area.
  
  
  METHODS
  We used 28 albino Wistar rat of both genders. After the animal fixation on stereotaxic apparatus to dry bone, the places for electrode fixation were marked. Two days after the electrodes had been implanted an EEG was registered so that the animals would adjust to the conditions and so they would repair the tissue reactions. EEG was registered with bipolar electrodes with ten-channeled apparatus. For first half an hour spontaneous activity of the brain was registered, and after that the head of nucleus caudate was stimulated with altered impulses of various voltages, frequency and duration.
  
  
  CONCLUSIONS
  Threshold values of electric stimulus intensity from 3 to 5 V, frequency from 3 to 5 Hz, duration from 3 to 5 ms, by stimulation the head of nucleus caudate of rat, lead to the change of basal bioelectric activity of cerebrum. The change of bioelectric activity is firstly recorded in equilateral cortex, and with the higher intensity of the stimulus the changes overtake the contra lateral cortex.
authors.affiliation: Faculty of Medicine Foca, University of East Sarajevo Studentska 1, 73300 Foca, Bosnia and Herzegovina.
authors.forename: Snezana
authors.initials: S
authors.lastname: Medenica-Milanović
authors.forename: Sinisa
authors.initials: S
authors.lastname: Ristić
authors.forename: Vladimir
authors.initials: V
authors.lastname: Turuntas
authors.forename: Mirjana
authors.initials: M
authors.lastname: Mirić
authors.forename: Milan
authors.initials: M
authors.lastname: Kulić
mesh_terms: D000818:Animals; D002421:Caudate Nucleus / Q000502:physiology*; D003342:Corpus Striatum / Q000502:physiology; D004558:Electric Stimulation; D004569:Electroencephalography; D005260:Female; D008297:Male; D009044:Motor Cortex / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D013003:Somatosensory Cortex / Q000502:physiology*; D013788:Thalamus / Q000502:physiology