Synthesis of an A-E gambieric acid subunit with use of a C-glycoside centered strategy.
This paper describes our synthesis of the A-E subunit of gambieric acid (GA) in addition to the synthesis of the A-ring and the C-E tricycle. The use of an enol ether-olefin RCM strategy to couple the A and C-E subunits and, in the process, generate the B-ring is noteworthy.
Roberts
Scott W
SW
Department of Chemistry, University of Utah, Salt Lake City, Utah 84112, USA.
Rainier
Jon D
JD
D000818:Animals; D002922:Ciguatoxins / Q000737:chemistry* / Q000378:metabolism; D004141:Dinoflagellida / Q000378:metabolism; D004988:Ethers, Cyclic / Q000737:chemistry* / Q000378:metabolism; D015394:Molecular Structure
D004988:Ethers, Cyclic; D002922:Ciguatoxins; C080898:gambieric acid A