title: Cognitive function, mood and health-related quality of life in hepatitis C virus (HCV)-monoinfected and HIV/HCV-coinfected individuals commencing HCV treatment.
abstract: OBJECTIVE
  The aim of the study was to examine cognitive function, mood and health-related quality of life (HRQOL), and their interrelationships, among hepatitis C virus (HCV)-monoinfected and HIV/HCV-coinfected individuals.
  
  
  METHODS
  Baseline neuropsychological and HRQOL measures of HCV-monoinfected and HIV/HCV-coinfected individuals commencing HCV treatment were examined from a prospective cohort study conducted between April 2003 and August 2005 in Sydney, Australia. Participants' neuropsychological performance and HRQOL were measured using computer-based battery, Trail Making Tests (TMT), Depression Anxiety Stress Scales (DASS), the Hepatitis Quality of Life Questionnaire (HQLQ), and the Visual Analogue Scale (VAS). Neuropsychological measures of HCV-infected patient groups were compared with those of two control groups consisting of HIV-monoinfected and uninfected individuals.
  
  
  RESULTS
  Similar cognitive function, mood and HRQOL were found in HCV-monoinfected (n=19) and HIV/HCV-coinfected (n=15) individuals. When compared with the HIV-monoinfected (n=30) and uninfected control (n=30) groups, subtle cognitive impairment in attention was found in the HIV/HCV-coinfected group (P<0.05). Twenty-one percent of the HCV-monoinfected group were classified as having cognitive impairment compared with 10% or less in the other groups. Sociodemographic characteristics, mood, HRQOL and HCV indices did not correlate with cognitive function.
  
  
  CONCLUSIONS
  Our findings indicate no statistically significant difference in neuropsychological and HRQOL impairments between HIV/HCV-coinfected individuals with nonadvanced HIV disease and HCV-monoinfected individuals. This lack of significant difference may relate to the relatively small study population.
authors.affiliation: National Centre in HIV Epidemiology and Clinical Research, The University of New South Wales, Sydney, NSW, Australia.
authors.forename: Hh
authors.initials: H
authors.lastname: Thein
authors.forename: P
authors.initials: P
authors.lastname: Maruff
authors.forename: M
authors.initials: M
authors.lastname: Krahn
authors.forename: Jm
authors.initials: J
authors.lastname: Kaldor
authors.forename: Dj
authors.initials: Dj
authors.lastname: Koorey
authors.forename: Bj
authors.initials: B
authors.lastname: Brew
authors.forename: Gj
authors.initials: G
authors.lastname: Dore
mesh_terms: D000328:Adult; D000339:Affect; D003071:Cognition; D015331:Cohort Studies; D005260:Female; D006678:HIV / Q000254:growth & development*; D015658:HIV Infections / Q000276:immunology / Q000523:psychology* / Q000821:virology*; D016174:Hepacivirus / Q000254:growth & development*; D019698:Hepatitis C, Chronic / Q000276:immunology / Q000523:psychology* / Q000821:virology*; D006801:Humans; D008297:Male; D011446:Prospective Studies; D011788:Quality of Life; D018709:Statistics, Nonparametric; D011795:Surveys and Questionnaires