Biotransformation of (+)-cycloisolongifolol by plant pathogenic fungus Glomerella cingulata.
The biotransformation of terpenoids using the plant pathogenic fungus as a biocatalyst to produce useful novel organic compounds was investigated. The biotransformation of sesquiterpen alcohol, (+)-cycloisolongifolol (1) was investigated using plant pathogenic fungus Glomerella cingulata as a biocatalyst. Compound 1 gave one major metabolic product and a number of minor metabolic products. Major product was dehydration at the C-8 position to (+)-dehydrocycloisolongifolene (2). The structure of the product was determined by their spectroscopic data. Glomerella cingulata gave dehydration in the specifically and over 70% conversion.
Miyazawa
Mitsuo
M
Faculty of Science and Engineering, Department of Applied Chemistry, Kinki University, Kowakae, Osaka 577-8502, Japan. miyazawa@apch.kindai.ac.jp
Sakata
Kazuki
K
D001711:Biotransformation; D006863:Hydrogen-Ion Concentration; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D020081:Phyllachorales / Q000378:metabolism*; D010944:Plants / Q000382:microbiology*; D012717:Sesquiterpenes / Q000737:chemistry / Q000378:metabolism*; D013997:Time Factors
D012717:Sesquiterpenes; C502389:isolongifolol