title: Gene x environment effects: stress and memory dysfunctions caused by stress and gonadal factor irregularities during puberty in control and TGF-alpha hypomorphic mice.
abstract: The maturation of many neural functions occurs during puberty. An abnormal development of these processes, in the context of genetic vulnerability, may result in sex- and age-dependent penetrance of neuropsychiatric disorders. Reduced transforming growth factors-alpha (TGF-alpha) expression in Waved-1 (Wa-1) mice impairs the stress response and fear memory in adult males, but are absent or far less prominent in adult females and in pubertal males. Gonadectomy around the onset of puberty, when the mutant anatomical and behavioral phenotypes are undetectable, results in significant gene x environment effects. Adult control males show reduced physiological stress response as a result of gonadectomy, but not adult Wa-1 males. In females, pubertal gonadectomy elevates specific anxiety parameters only in adult control mice. There also are general sex-specific effects of pubertal gonadectomy on adult stress and fear memory. Surgical stress alone also induces sex- and genotype-dependent effects, albeit in different behavioral parameters than those affected by gonadectomy. We conclude that normal development of stress and memory processes is reliant on the levels of stress and gonadal factors during puberty, the effects of which are modulated by genetic factors and sex.
authors.affiliation: Department of Neurobiology and Center for Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, PA, USA. koshibu@hifo.unizh.ch
authors.forename: Kyoko
authors.initials: K
authors.lastname: Koshibu
authors.forename: Pat
authors.initials: P
authors.lastname: Levitt
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D003213:Conditioning, Psychological; D003345:Corticosterone / Q000097:blood; D005239:Fear / Q000523:psychology; D005260:Female; D005334:Fever / Q000209:etiology / Q000523:psychology; D016014:Linear Models; D008297:Male; D008569:Memory Disorders / Q000209:etiology / Q000523:psychology*; D051379:Mice; D008810:Mice, Inbred C57BL; D009043:Motor Activity; D009919:Orchiectomy; D010052:Ovariectomy; D019683:Penetrance; D012741:Sexual Maturation / Q000502:physiology*; D013315:Stress, Psychological / Q000150:complications / Q000523:psychology*; D016211:Transforming Growth Factor alpha / Q000235:genetics* / Q000502:physiology*
chemical_list: D016211:Transforming Growth Factor alpha; D003345:Corticosterone