Dietary fish oil as hepatoprotective agent in Mus musculus.
The administration of galactosamine in omega-3 polyunsatu-rated fatty acid (PUFA) supplemented mice resulted in lesser amount of damage in the liver tissue compared to the mice without prior supplementation of fish oil. Only 50% elevation in the plasma total bilirubin was detected in omega-3 supplemented mice injected with galactosamine over those supplemented with omega-3 without galactosomine injection. The results suggest that very long chain omega-3 PUFA like eicosapentaenoic and docosahexaenoic acid may act as preventive agent for hepatic cirrhosis in Mus musculus.
Roy
R
R
Department of Zoology, Taleigao Plateau, Goa University, Goa 403 206, India. rroy@unigoa.ac.in
Chandrasekhar
D
D
Pujari
P
P
D000818:Animals; D001663:Bilirubin / Q000097:blood; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage*; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage* / Q000032:analysis; D005395:Fish Oils / Q000008:administration & dosage* / Q000737:chemistry; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008103:Liver Cirrhosis / Q000473:pathology / Q000517:prevention & control*; D051379:Mice
D004042:Dietary Fats, Unsaturated; D015525:Fatty Acids, Omega-3; D005395:Fish Oils; D001663:Bilirubin