title: Heritability of blood pressure responses to dietary sodium and potassium intake in a Chinese population.
abstract: The heritability of blood pressure responses to dietary intervention has not been well studied. We examined the heritability of blood pressure responses to dietary sodium and potassium intake in a family feeding study among 1906 study participants living in rural North China. The dietary intervention included a 7-day low-sodium feeding (51.3 mmol per day), a 7-day high-sodium feeding (307.8 mmol per day), and a 7-day high-sodium plus potassium supplementation (60 mmol per day). Blood pressure was measured 9 times during the 3-day baseline period preceding the intervention and also during the last 3 days of each intervention phase using a random-zero sphygmomanometer. Heritability was computed using maximum likelihood methods under a variance components model as implemented in the computer program SOLAR. The heritabilities of baseline blood pressure were 0.31 for systolic, 0.32 for diastolic, and 0.34 for mean arterial pressure. The heritabilities increased significantly under dietary intervention and were 0.49, 0.49, and 0.51 during low sodium; 0.47, 0.49, and 0.51 during high sodium; and 0.51, 0.52, and 0.53 during potassium supplementation for systolic, diastolic, and mean arterial pressure, respectively. The heritabilities for percentage of blood pressure responses to low sodium were 0.20, 0.21, and 0.23; to high-sodium were 0.22, 0.33, and 0.33; and to potassium supplementation were 0.24, 0.21, and 0.25 for systolic, diastolic, and mean arterial pressure, respectively. Our study indicated that the heritabilities of blood pressure under controlled dietary sodium and potassium intake were significantly higher than those under a usual diet. In addition, the heritabilities of blood pressure responses to dietary sodium and potassium intake were moderate in this study population.
authors.affiliation: Cardiovascular Institute and Fu Wai Hospital, Beijing, China. gudongfeng@vip.sina.com
authors.forename: Dongfeng
authors.initials: D
authors.lastname: Gu
authors.forename: Treva
authors.initials: T
authors.lastname: Rice
authors.forename: Shiping
authors.initials: S
authors.lastname: Wang
authors.forename: Wenjie
authors.initials: W
authors.lastname: Yang
authors.forename: Chi
authors.initials: C
authors.lastname: Gu
authors.forename: Chung-Shiuan
authors.initials: CS
authors.lastname: Chen
authors.forename: James E
authors.initials: JE
authors.lastname: Hixson
authors.forename: Cashell E
authors.initials: CE
authors.lastname: Jaquish
authors.forename: Zhi-Jian
authors.initials: ZJ
authors.lastname: Yao
authors.forename: De-Pei
authors.initials: DP
authors.lastname: Liu
authors.forename: Dabeeru C
authors.initials: DC
authors.lastname: Rao
authors.forename: Jiang
authors.initials: J
authors.lastname: He
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics*; D001794:Blood Pressure / Q000187:drug effects* / Q000235:genetics*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D016013:Likelihood Functions; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D017419:Potassium, Dietary / Q000008:administration & dosage* / Q000494:pharmacology; D012982:Sodium, Dietary / Q000008:administration & dosage* / Q000494:pharmacology; D012984:Software; D019722:Sphygmomanometers
chemical_list: D017419:Potassium, Dietary; D012982:Sodium, Dietary