title: Neutralizing viruses in suspensions by copper oxide-based filters.
abstract: We report the capacity of copper oxide-containing filters to reduce infectious titers of a panel of viruses spiked into culture media. Enveloped, nonenveloped, RNA, and DNA viruses were affected, suggesting the possibility of using copper oxide-containing devices to deactivate a wide spectrum of infectious viruses found in filterable suspensions.
authors.affiliation: Ruth Ben-Ari Institute of Clinical Immunology, Kaplan Medical Center, Rehovot 76100, Israel. gadi@cupron.com
authors.forename: Gadi
authors.initials: G
authors.lastname: Borkow
authors.forename: Robert W
authors.initials: RW
authors.lastname: Sidwell
authors.forename: Donald F
authors.initials: DF
authors.lastname: Smee
authors.forename: Dale L
authors.initials: DL
authors.lastname: Barnard
authors.forename: John D
authors.initials: JD
authors.lastname: Morrey
authors.forename: Humberto H
authors.initials: HH
authors.lastname: Lara-Villegas
authors.forename: Yonat
authors.initials: Y
authors.lastname: Shemer-Avni
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Gabbay
mesh_terms: D000818:Animals; D001769:Blood / Q000821:virology; D002460:Cell Line; D002522:Chlorocebus aethiops; D003300:Copper / Q000494:pharmacology*; D004267:DNA Viruses / Q000187:drug effects; D004285:Dogs; D004847:Epithelial Cells / Q000821:virology; D005347:Fibroblasts / Q000821:virology; D005374:Filtration / Q000295:instrumentation / Q000379:methods; D015497:HIV-1 / Q000187:drug effects; D006367:HeLa Cells; D006801:Humans; D009500:Neutralization Tests; D012328:RNA Viruses / Q000187:drug effects; D013535:Suspensions; D014709:Vero Cells; D014780:Viruses / Q000187:drug effects*
chemical_list: D013535:Suspensions; D003300:Copper