The interaction between orally administered non-steroidal anti-inflammatory drugs and prednisolone in healthy dogs.
The interaction between oral non-steroidal anti-inflammatory drugs (NSAIDs) and prednisolone administered concurrently for 30 days was studied in 18 healthy dogs divided into 3 groups of 6 dogs each: a drug-free negative control group (NC group) given 2 gelatin capsules; a group given meloxicam (0.1 mg/kg) and prednisolone (0.5 mg/kg) (MP group); and a group given a reduced dosage of ketoprofen (0.25 mg/kg, p.o.) and prednisolone (0.5 mg/kg, p.o.) (KP group). The dogs were periodically monitored by physical examinations, blood analyses, endoscopic examinations, fecal occult blood tests, renal function tests [effective renal plasma flow (ERPF) and glomerular filtration rate (GFR)], urinalyses [urinary sediments, and urinary micro-albumin to creatinine ratio (UAlb/Cre)], urinary enzyme indices, and haemostatic function tests [buccal mucosa bleeding time (BMBT), cuticle bleeding time (CBT)]. Significant changes were observed in the KP group, including a decrease of ERPF and GFR, an increased UAlb/Cre ratio, prolonged BMBT and CBT, as well as the presence of more severe grades of endoscopic lesions and fecal occult blood. In both the MP and KP groups, abnormal enzymuria with exfoliation of renal tubular epithelial cells in the urine was found. However, no significant changes in any of the other tests were observed in the MP group compared with the NC group. These findings suggest that the combination of NSAIDs, even selective COX-2 inhibitors, with prednisolone may be contraindicated due to the potential for serious adverse effects on the kidneys, the platelets, and the gastrointestinal tract.
Narita
Tatsuya
T
Department of Clinical Veterinary Science, The United Graduate School of Veterinary Sciences, Gifu University, Japan.
Sato
Reeko
R
Motoishi
Keita
K
Tani
Kenji
K
Naito
Yoshihisa
Y
Hara
Shigeo
S
D000118:Acetylglucosaminidase / Q000652:urine; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology* / Q000633:toxicity; D001760:Bleeding Time / Q000662:veterinary; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology* / Q000633:toxicity; D004285:Dogs / Q000378:metabolism* / Q000652:urine; D004347:Drug Interactions; D004724:Endoscopy / Q000662:veterinary; D005260:Female; D005767:Gastrointestinal Diseases / Q000139:chemically induced / Q000473:pathology; D005919:Glomerular Filtration Rate / Q000187:drug effects; D007660:Ketoprofen / Q000031:analogs & derivatives / Q000494:pharmacology / Q000633:toxicity; D007674:Kidney Diseases / Q000139:chemically induced / Q000652:urine; D000077239:Meloxicam; D009780:Occult Blood; D011239:Prednisolone / Q000494:pharmacology* / Q000633:toxicity; D011897:Random Allocation; D017596:Renal Plasma Flow, Effective / Q000187:drug effects; D018709:Statistics, Nonparametric; D013843:Thiazines / Q000494:pharmacology / Q000627:therapeutic use / Q000633:toxicity; D013844:Thiazoles / Q000494:pharmacology / Q000627:therapeutic use / Q000633:toxicity; D016482:Urinalysis / Q000662:veterinary; D005723:gamma-Glutamyltransferase / Q000652:urine
D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors; D013843:Thiazines; D013844:Thiazoles; D007660:Ketoprofen; D011239:Prednisolone; D005723:gamma-Glutamyltransferase; D000118:Acetylglucosaminidase; D000077239:Meloxicam