Novel oral agents for multiple sclerosis.
In 1993, interferon beta-1b, the first clinically proven disease-modifying agent for multiple sclerosis, was approved, with several comparable agents following close behind. These agents have been beneficial in reducing relapse events and MRI lesions, but all require parenteral administration, leading some otherwise eligible patients to decline such therapies. Oral agents have been studied for decades with mixed results, but a small number of medications currently being tested in phase II/III clinical trials have shown promise in efficacy and tolerability. This review assesses the results of the more thoroughly studied of these agents, some of which may soon be approved for use in multiple sclerosis.
Burton
Jodie M
JM
Multiple Sclerosis Clinic, Division of Neurology, St. Michael's Hospital, 30 Bond Street, Toronto, Ontario M5B 1W8, Canada. burtonj@smh.toronto.on.ca
O'Connor
Paul
P
D000284:Administration, Oral; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D017338:Cladribine / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D000069462:Dimethyl Fumarate; D000068876:Fingolimod Hydrochloride; D005650:Fumarates / Q000627:therapeutic use; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000627:therapeutic use; D000068576:Interferon beta-1b; D016899:Interferon-beta / Q000627:therapeutic use; D007555:Isoxazoles / Q000378:metabolism / Q000627:therapeutic use; D000077339:Leflunomide; D008911:Minocycline / Q000627:therapeutic use; D009103:Multiple Sclerosis / Q000188:drug therapy*; D009173:Mycophenolic Acid / Q000031:analogs & derivatives / Q000627:therapeutic use; D011409:Propylene Glycols / Q000627:therapeutic use; D011728:Pyridones / Q000627:therapeutic use; D015363:Quinolones / Q000627:therapeutic use; D013110:Sphingosine / Q000031:analogs & derivatives / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D005650:Fumarates; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D007166:Immunosuppressive Agents; D007555:Isoxazoles; D011409:Propylene Glycols; D011728:Pyridones; D015363:Quinolones; D000068576:Interferon beta-1b; D017338:Cladribine; D016899:Interferon-beta; C476223:laquinimod; C093844:pirfenidone; D000069462:Dimethyl Fumarate; D008911:Minocycline; D000077339:Leflunomide; D000068876:Fingolimod Hydrochloride; D009173:Mycophenolic Acid; D013110:Sphingosine