title: Recurrent gestational trophoblastic disease after hCG normalization following hydatidiform mole in The Netherlands.
abstract: OBJECTIVE
  To determine the risk for recurrent trophoblastic disease after spontaneous normalization of human chorionic gonadotropin (hCG) levels in patients with hydatidiform mole and to determine the risk for tumor relapse after apparent remission following chemotherapy in patients with low- and high-risk persistent trophoblastic disease.
  
  
  METHODS
  From 1994 until 2004, 355 patients with hydatidiform mole were registered at the Dutch Central Registry of Hydatidiform Mole and were monitored by sequential hCG assays in serum at the department of Chemical Endocrinology of the Radboud University Nijmegen Medical Centre. HCG regression curves were analyzed together with clinical information collected from the Hydatidiform Mole Database.
  
  
  RESULTS
  Among the 355 registered hydatidiform mole patients, 265 patients attained spontaneous normalization following evacuation. Of the 265 patients, one patient (0.38%) subsequently required chemotherapeutic treatment for recurrent trophoblastic disease (95% confidence interval 0.0% to 2.1%). HCG levels did not decline to normal (<2.0 ng/ml) spontaneously in 90 patients; those patients were subsequently treated. Relapse rates were 8.1% (6/74) and 6.3% (1/16) for the low- and high-risk category respectively.
  
  
  CONCLUSIONS
  Our analysis indicates that relapse risk in hydatidiform mole patients with spontaneous normalization is extremely low (one in 265 patients) after two normal hCG levels (<2.0 ng/ml) are achieved. Our results support the suggestion that two subsequent normal hCG levels may be sufficient to ensure sustained remission after hydatidiform mole evacuation. In contrary, in order to assure sustained remission, the relapse rates after chemotherapy in the current study emphasize the need for surveillance of trophoblastic tumor patients even after complete remission has apparently been achieved.
authors.affiliation: Department of Obstetrics and Gynaecology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
authors.forename: Linda G W
authors.initials: LG
authors.lastname: Kerkmeijer
authors.forename: Sabien
authors.initials: S
authors.lastname: Wielsma
authors.forename: Leon F A G
authors.initials: LF
authors.lastname: Massuger
authors.forename: Fred C G J
authors.initials: FC
authors.lastname: Sweep
authors.forename: Chris M G
authors.initials: CM
authors.lastname: Thomas
mesh_terms: D000293:Adolescent; D000328:Adult; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000097:blood*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006828:Hydatidiform Mole / Q000097:blood* / Q000453:epidemiology; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000097:blood* / Q000453:epidemiology; D009426:Netherlands; D011247:Pregnancy; D012042:Registries; D012307:Risk Factors; D014328:Trophoblastic Neoplasms / Q000097:blood* / Q000453:epidemiology; D014594:Uterine Neoplasms / Q000097:blood* / Q000453:epidemiology
chemical_list: D018997:Chorionic Gonadotropin, beta Subunit, Human