Tweak and FN14 in central nervous system health and disease.
The tumor necrosis factor superfamily (TNFSF) of cytokines comprises 19 ligands and 28 receptors (1). Ligand-mediated activation of TNFSF receptors plays a role in the pathogenesis of multiple central nervous system (CNS) diseases such as multiple sclerosis (2) and cerebral ischemia (3). Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) is a member of the TNFSF (4) that binds a small cell surface receptor known as fibroblast growth factor-inducible 14 (Fn14) (5-7). There is a growing body of evidence indicating that the interaction between TWEAK and Fn14 plays a role on cell death, regulation of the permeability of the neurovascular unit (NVU) and development of an inflammatory response in the CNS under physiological and pathological conditions (8, 9). Accordingly, here we will review the information available to this date on the role of this cytokine and its receptor in the CNS.
Yepes
Manuel
M
Department of Neurology and Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, Georgia 30322, USA. myepes@emory.edu
D000818:Animals; D002490:Central Nervous System / Q000502:physiology*; D002493:Central Nervous System Diseases / Q000503:physiopathology*; D000074049:Cytokine TWEAK; D006801:Humans; D018124:Receptors, Tumor Necrosis Factor / Q000502:physiology*; D000074050:TWEAK Receptor; D048069:Tumor Necrosis Factors / Q000502:physiology*
D000074049:Cytokine TWEAK; D018124:Receptors, Tumor Necrosis Factor; C000613297:TNFRSF12A protein, human; C109743:TNFSF12 protein, human; D000074050:TWEAK Receptor; D048069:Tumor Necrosis Factors