Paradoxes of the EphB4 receptor in cancer.
Recent findings have started to uncover the intriguing roles of the Eph family of receptor tyrosine kinases in normal epithelial cells and during oncogenic transformation. This review focuses on EphB4, an Eph receptor that has both tumor-suppressing and tumor-promoting activities in breast cancer. Understanding the multifaceted role of EphB4 in tumorigenesis may allow the development of new anticancer therapies.
Noren
Nicole K
NK
Burnham Institute for Medical Research and Pathology Department, University of California San Diego, La Jolla, California 92037, USA.
Pasquale
Elena B
EB
D000818:Animals; D001943:Breast Neoplasms / Q000201:enzymology*; D006801:Humans; D008325:Mammary Neoplasms, Experimental / Q000201:enzymology*; D036224:Receptor, EphB4 / Q000502:physiology*
D036224:Receptor, EphB4