NAN-190 potentiates the impairment of retention produced by swim stress.
Exposing rats to stress in the form of forced swim immediately after passive-avoidance training impaired retention. In contrast, exposure to the same stressor 2 h after training failed to impair retention. Systemic administration of the 5-HT1A receptor antagonist NAN-190 (1 mg/kg) immediately after forced swim markedly potentiated the stress-induced impairment of retention. In contrast, NAN-190 failed to affect retention when administered 2 h after forced swim or in forced swim's absence. These findings provide evidence for a NAN-190-sensitive system modulating retention that is 1) activated during a critical period shortly after exposure to swim stress, and 2) protective of memory, thereby limiting the extent to which retention is impaired by experiential stress.
Schneider
Allen M
AM
Department of Psychology, Swarthmore College, Swarthmore, Pennsylvania 19081, USA. ASchnei1@Swarthmore.edu
Simson
Peter E
PE
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004597:Electroshock; D007101:Immersion; D008297:Male; D008569:Memory Disorders / Q000139:chemically induced* / Q000209:etiology / Q000523:psychology*; D010879:Piperazines / Q000494:pharmacology*; D051381:Rats; D020318:Rats, Long-Evans; D012702:Serotonin Antagonists / Q000494:pharmacology*; D013315:Stress, Psychological / Q000523:psychology*; D013550:Swimming / Q000523:psychology*
D010879:Piperazines; D012702:Serotonin Antagonists; C058895:1-(2-methoxyphenyl)-4-(4-(2-phthalimido)butyl)piperazine