[Gastric cancer producing AFP/HCG which had a rapidly progressive course with metastasis to the brain discovered postoperatively].
A 69-year-old man was admitted to our hospital with nausea and vomiting. Gastric endoscopy revealed advanced gastric cancer in the upper body of the stomach. Serum AFP increased to 254 ng/ml, but abdominal CT showed no liver metastasis. Total gastrectomy was performed and histologic examination revealed poorly differentiated adenocarcinoma, and positive immunohistochemical staining for AFP and HCG. He was discharged without complications at postoperative day 19. However, he was admitted again with severe headache 3 days later. Brain CT showed a high density mass in the cerebellum. Tumorectomy was performed, and brain metastasis from the gastric cancer was confirmed pathologically.
Ohdaira
Hironori
H
Department of Surgery, Machida Municipal Hospital, Japan.
Murai
Ryuzo
R
Hanyu
Nobuyoshi
N
Abe
Mitsufumi
M
Yanaga
Katsuhiko
K
D000230:Adenocarcinoma / Q000378:metabolism / Q000556:secondary* / Q000601:surgery; D000368:Aged; D002528:Cerebellar Neoplasms / Q000556:secondary* / Q000601:surgery; D006063:Chorionic Gonadotropin / Q000096:biosynthesis*; D018450:Disease Progression; D005743:Gastrectomy; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D011184:Postoperative Period; D013274:Stomach Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D000509:alpha-Fetoproteins / Q000096:biosynthesis*
D006063:Chorionic Gonadotropin; D000509:alpha-Fetoproteins