Differential neuroimmune markers to the onset of Alzheimer's disease neurodegeneration and dementia: autoantibodies to Abeta((25-35)) oligomers, S100b and neurotransmitters.
Alzheimer's disease (AD) autoimmunity is a focus for dementia prevention. Generated autoantibodies against major etiopathogenic molecular targets as neuroimmune markers of dementia were measured by ELISA in patient sera. Biphasic antibody levels to Abeta((25-35)) oligomers, S100b and DA were detected during distinctly diagnosed dementia stages. Abeta((25-35)) oligomer autoimmune responses reflected mild to moderate AD dementia, while those to S100b, DA and the S100b concentrations, matched moderate to severe dementia progression. 5-HT antibodies increased during mild dementia and plateaued thereafter. This autoimmunity pattern may be used as a differential biomarker profile in designing AD therapeutic strategies involving early vaccination.
Gruden
Marina A
MA
P. K. Anokhin Institute of Normal Physiology, RAMS, Moscow, Russia.
Davidova
Tatyana B
TB
Malisauskas
Mantas
M
Sewell
Robert D E
RD
Voskresenskaya
Nina I
NI
Wilhelm
Kristina
K
Elistratova
Elena I
EI
Sherstnev
Vladimir V
VV
Morozova-Roche
Ludmilla A
LA
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000150:complications / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D016229:Amyloid beta-Peptides / Q000276:immunology*; D000906:Antibodies / Q000378:metabolism*; D003072:Cognition Disorders / Q000209:etiology; D004298:Dopamine; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging / Q000379:methods; D009410:Nerve Degeneration / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D009414:Nerve Growth Factors / Q000276:immunology*; D010446:Peptide Fragments / Q000276:immunology / Q000378:metabolism; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000276:immunology*; D012701:Serotonin / Q000378:metabolism
D016229:Amyloid beta-Peptides; D000906:Antibodies; D009414:Nerve Growth Factors; D010446:Peptide Fragments; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; C579160:S100B protein, human; D012701:Serotonin; D004298:Dopamine