title: Biomechanical correlates of mild diffuse brain injury in the rat.
abstract: The relationship between diffuse brain injury (DBI) occurrence and impact biomechanics is well documented. Previous studies attempted to develop injury thresholds based on various biomechanical parameters and have demonstrated inconsistent results. The spectral nature of DBI requires robust metrics capable of predicting injury occurrence and severity. In the present study impact biomechanics reported previously were correlated to rat unconsciousness time. Significant correlation was identified in three parameters including square angular velocity, change in rotational velocity, and Head Impact Power. Results suggest rotational loading of the rat head has similar correlates to the human condition. In addition, certain biomechanical parameters demonstrate capacity for predicting DBI severity.
authors.affiliation: Department of Neurosurgery, Medical College of Wisconsin and Veterans Affairs Medical Center 9200 West Wisconsin Avenue, Milwaukee, WI 53226, USA.
authors.forename: Ronald J
authors.initials: RJ
authors.lastname: Fijalkowski
authors.forename: Brian D
authors.initials: BD
authors.lastname: Stemper
authors.forename: Frank A
authors.initials: FA
authors.lastname: Pintar
authors.forename: Narayan
authors.initials: N
authors.lastname: Yoganandan
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Gennarelli
mesh_terms: D000054:Acceleration / Q000009:adverse effects*; D000818:Animals; D001696:Biomechanical Phenomena / Q000379:methods; D001921:Brain / Q000503:physiopathology*; D001930:Brain Injuries / Q000145:classification / Q000209:etiology / Q000503:physiopathology*; D003198:Computer Simulation; D019416:Head Movements; D008297:Male; D008954:Models, Biological; D010812:Physical Stimulation / Q000009:adverse effects* / Q000379:methods; D051381:Rats; D017207:Rats, Sprague-Dawley; D012720:Severity of Illness Index; D014474:Unconsciousness / Q000145:classification / Q000209:etiology / Q000503:physiopathology*; D014949:Wounds, Nonpenetrating / Q000145:classification / Q000209:etiology / Q000503:physiopathology*