title: Acute tumour lysis syndrome in a dog with B-Cell multicentric lymphoma.
abstract: A 5-year-old, spayed female German Shepherd dog was admitted to hospital with marked generalised lymphadenomegaly and splenomegaly. A stage Va B-cell multicentric lymphoma was diagnosed on clinical, cytological (lymph node, bone marrow), histological-immunohistochemical (lymph node excision) and imaging grounds. Since no satisfactory remission was achieved using a multi-drug chemotherapy protocol that included cyclophosphamide, vincristine, cytosine arabinoside, prednisolone, and subsequently supplemented by L-asparaginase, it was replaced by another protocol combining vincristine, L-asparaginase, prednisolone, cyclophosphamide and doxorubicin. Soon after the third weekly session of the second protocol, the clinical status of the animal deteriorated suddenly and severely, with a bleeding tendency, jaundice, hyperuricaemia, hyperphosphataemia, azotaemia, hyperbilirubinaemia and, presumptive disseminated intravascular coagulation. There was also complete regression of lymphadenomegaly. This report emphasises the clinicopathological features and the diagnostic peculiarities of the acute tumour lysis syndrome, which occurs uncommonly in dogs.
authors.affiliation: Companion Animal Clinic, Faculty of Veterinary Medicine, Aristotle University of Thessaloniki, Greece. mmylonak@vet.auth.gr
authors.forename: M E
authors.initials: ME
authors.lastname: Mylonakis
authors.forename: A F
authors.initials: AF
authors.lastname: Koutinas
authors.forename: N
authors.initials: N
authors.lastname: Papaioannou
authors.forename: S
authors.initials: S
authors.lastname: Lekkas
mesh_terms: D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D004283:Dog Diseases / Q000188:drug therapy* / Q000473:pathology; D004285:Dogs; D017809:Fatal Outcome; D005260:Female; D016393:Lymphoma, B-Cell / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D015275:Tumor Lysis Syndrome / Q000209:etiology / Q000662:veterinary*