Noncardiogenic pulmonary edema associated with clopidogrel: a serious but unexpected side effect of clopidogrel.
Clopidogrel has a favourable side effect profile, in which the most serious complications are related to bleeding diathesis. Drug reactions represent frequently encountered clinical problems that can also be life-threatening. In the present case, serious noncardiogenic pulmonary edema was observed as an idiosyncratic reaction after clopidogrel use. Using the Naranjo adverse drug reactions probability scale, a possible likelihood of this putative interaction between clopidogrel and pulmonary edema was calculated. Such an adverse effect of clopidogrel has never been reported before. The present report shows the importance of recognizing rare adverse reactions of newer drugs, such as clopidogrel, in clinical practice.
Erdinler
Izzet Celal
IC
Dr Siyami Ersek Thoracic and Cardiovascular Surgery Center, Istanbul, Turkey.
Ucer
Ekrem
E
Eksik
Abdurrahman
A
Akyol
Ahmet
A
Yazici
Selcuk
S
D000368:Aged; D017130:Angioplasty; D001774:Blood Chemical Analysis; D016893:Carotid Stenosis / Q000628:therapy*; D000077144:Clopidogrel; D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage / Q000009:adverse effects*; D011654:Pulmonary Edema / Q000097:blood / Q000139:chemically induced* / Q000175:diagnosis* / Q000000981:diagnostic imaging; D011859:Radiography; D013988:Ticlopidine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*
D010975:Platelet Aggregation Inhibitors; D000077144:Clopidogrel; D013988:Ticlopidine