[DNA topoisomerase and telomerase activity with relation to multi-drug resistance in leukemia--review].
The appearance of multi-drug resistance becomes a key to treat many malignancies, and also is an important factor in the failure of chemotherapy. Presently, the studies on multi-drug resistance mechanism, reversor and associated exterior experiments in vivo and in vitro from different points of view and levels show that multi-drug resistance is the result of common action in many factors. In recent years non-representative mechanism of multi-drug resistance becomes more and more significant. This review aims at establishing rationale basis for reversing multi-drug resistance of leukemia and finding effective reversors by expounding the mechanism of apoptosis in drug resistance of leukemia with relation to DNA topoisomerase and telomerase activity.
Li
Shou-Juan
SJ
Institute of Hematology, Clinical Medical College, Yangzhou University, Yangzhou 225001, China.
Gu
Jian
J
D000970:Antineoplastic Agents / Q000627:therapeutic use; D004264:DNA Topoisomerases, Type I / Q000378:metabolism*; D018432:Drug Resistance, Multiple; D019008:Drug Resistance, Neoplasm; D006801:Humans; D007938:Leukemia / Q000188:drug therapy / Q000201:enzymology*; D019098:Telomerase / Q000378:metabolism*
D000970:Antineoplastic Agents; D019098:Telomerase; D004264:DNA Topoisomerases, Type I