title: The amount of fibrinogen-positive platelets predicts the occurrence of in-stent restenosis.
abstract: OBJECTIVE
  To determine the value of fibrinogen-positive platelet-analysis in predicting restenosis after stent implantation in acute myocardial infarction patients.
  
  
  RESULTS
  Our patient population comprised 50 patients who underwent intravascular ultrasound (IVUS) guided stent implantation for acute myocardial infarction. In all cases, IVUS confirmed a deep vessel wall injury due to a ruptured plaque within the culprit lesion. Flow cytometry quantified the amount of platelets with surface-bound fibrinogen and thrombospondin before and immediately after the intervention. After 5 months, IVUS was repeated to assess the long-term results. In-stent restenosis - defined as a percent diameter stenosis of >50% - was detected in 11 of 45 patients who attended follow-up angiography. The amount of fibrinogen-positive platelets was significantly higher among patients who subsequently developed in-stent restenosis (50.5+/-6.8% fibrinogen-positive platelets immediately after intervention) than among those who did not (39.7+/-12.3% fibrinogen-positive platelets, p<0.005). Receiver operating characteristic curve revealed a 40% cut-off for fibrinogen-positive platelets immediately after the intervention to predict restenosis (p<0.05, sensitivity: 90.9%, specificity: 47.1%).
  
  
  CONCLUSIONS
  The amount of fibrinogen-positive platelets immediately after stent implantation predicts the occurrence of in-stent restenosis, as confirmed by IVUS in acute myocardial infarction patients.
authors.affiliation: Medical Clinic II, Campus Benjamin Franklin, Charité-Universitätsmedizin Berlin, Berlin, Germany.
authors.forename: Markus
authors.initials: M
authors.lastname: Jaster
authors.forename: Dieter
authors.initials: D
authors.lastname: Horstkotte
authors.forename: Tobias
authors.initials: T
authors.lastname: Willich
authors.forename: Caroline
authors.initials: C
authors.lastname: Stellbaum
authors.forename: Wulf
authors.initials: W
authors.lastname: Knie
authors.forename: Sebastian
authors.initials: S
authors.lastname: Spencker
authors.forename: Mathias
authors.initials: M
authors.lastname: Pauschinger
authors.forename: Heinz-Peter
authors.initials: HP
authors.lastname: Schultheiss
authors.forename: Ursula
authors.initials: U
authors.lastname: Rauch
mesh_terms: D000328:Adult; D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D015415:Biomarkers / Q000378:metabolism; D001792:Blood Platelets / Q000378:metabolism*; D023903:Coronary Restenosis / Q000175:diagnosis* / Q000453:epidemiology / Q000378:metabolism*; D005260:Female; D005340:Fibrinogen / Q000378:metabolism*; D005434:Flow Cytometry; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000628:therapy; D011237:Predictive Value of Tests; D012307:Risk Factors; D015607:Stents; D019699:Thrombospondins / Q000378:metabolism; D018084:Ultrasonography, Interventional
chemical_list: D015415:Biomarkers; D019699:Thrombospondins; D005340:Fibrinogen