Giant cell lesions with a Noonan-like phenotype: a case report.
OBJECTIVE
The purpose of this article is to describe a case of multiple giant cell lesions of the mandible that occurred in a 14-year-old girl with phenotypic characteristics associated with Noonan Syndrome (NS).


BACKGROUND
NS is a dysmorphic disorder characterized by hypertelorism, short stature, congenital heart defects, short and webbed neck, skeletal anomalies, and bleeding diathesis.


METHODS
A 14-year-old girl with a previous diagnosis of NS (sporadic case) presented with multiple radiolucent lesions in the body and ramus of her mandible.


CONCLUSIONS
In terms of clinical behavior and the described radiographic characteristics, giant cells lesions with Noonan-like phenotype can be considered a form of cherubism. Therefore, surgical intervention is not necessary, but radiographic follow-up and observation is very important during the control and gradual regression of the lesions.
Cancino
Claudia Marcela H
CM
Porto Alegre, RS, Brazil. marcelaforerocancino@hotmail.com
Gaião
Léonilson
L
Sant'Ana Filho
Manoel
M
Oliveira
Flavio Augusto Marsiaj
FA
D000293:Adolescent; D002636:Cherubism / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology; D005260:Female; D015726:Giant Cells / Q000473:pathology*; D006801:Humans; D008336:Mandibular Diseases / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology; D009634:Noonan Syndrome / Q000150:complications*; D011859:Radiography; D012075:Remission, Spontaneous