[Parallel analysis of c-Fos protein and interleukin-2 expression in hypothalamic cells under different influence].
The objective of this work was to perform a parallel analysis of activation of the rat anterior hypothalamus cells as judged by c-Fos protein expression, and of the expression of interleukin-2 (IL-2) under different influences, i. e., mild stress (handling) and adaptation to it, and intranasal administration of saline and the peptides Vilon (Lys-Glu) and Epithalon (Ala-Glu-Asp-Gly). Changes in the counts of cells positive for c-Fos- and IL-2 proteins were studied in structures of the lateral (LHA) area, anterior (AHN), supraoptic (SO) and paraventricular (PVH) nuclei of Wistar rat hypothalamus. Quantity of the interleukin-2-positive and c-Fos-positive cells was calculated. The findings were: a negative correlation between the activation of cells and the amount of IL-2 in the cells in the hypothalamic structures under study, and the specific patterns of changes in the counts of cells positive for c-Fos and IL-2 under stress and adaptation to stress.
Barabanova
S V
SV
Artiukhina
Z E
ZE
Ovchinnikova
K T
KT
Abramova
T V
TV
Kazakova
T B
TB
Khavinson
V Kh
VKh
Malinin
V V
VV
Korneva
E A
EA
D000818:Animals; D004151:Dipeptides / Q000494:pharmacology; D005786:Gene Expression Regulation / Q000187:drug effects; D007031:Hypothalamus / Q000378:metabolism* / Q000473:pathology; D007376:Interleukin-2 / Q000096:biosynthesis*; D008297:Male; D009842:Oligopeptides / Q000494:pharmacology; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis*; D051381:Rats; D017208:Rats, Wistar; D013312:Stress, Physiological / Q000378:metabolism* / Q000473:pathology
D004151:Dipeptides; D007376:Interleukin-2; D009842:Oligopeptides; D016760:Proto-Oncogene Proteins c-fos; C415909:lysylglutamic acid; C421253:alanyl-glutamyl-aspartyl-glycine