[Regulation of promoter activity through electrostatic interactions with RNA-polymerase].
Electrostatic profiles for sigma70-specific promoters of T4 bacteriophage and four consensus-like synthetic promoters have been calculated. It was shown that the promoters can be classified according to the presence of some specific electrostatic elements located in the far upstream region of their DNAs. A correlation between the electrostatic elements specific for promoters and their functional behaviour was established. A general scheme of promotor activity regulation through electrostatic interactions between the upstream region of promoter DNA and the RNA-polymerase a-subunit was suggested.
Kamzolova
S G
SG
Osipov
A A
AA
Beskaravaĭnyĭ
P M
PM
Dzheliadin
T R
TR
Sorokin
A A
AA
D017122:Bacteriophage T4 / Q000235:genetics*; D012321:DNA-Directed RNA Polymerases / Q000737:chemistry / Q000378:metabolism*; D015967:Gene Expression Regulation, Viral; D011401:Promoter Regions, Genetic; D012808:Sigma Factor / Q000378:metabolism; D055672:Static Electricity
D012808:Sigma Factor; C081775:RNA polymerase sigma 70; D012321:DNA-Directed RNA Polymerases