A review of near infrared spectroscopy and chemometrics in pharmaceutical technologies.
Near-infrared spectroscopy (NIRS) is a fast and non-destructive analytical method. Associated with chemometrics, it becomes a powerful tool for the pharmaceutical industry. Indeed, NIRS is suitable for analysis of solid, liquid and biotechnological pharmaceutical forms. Moreover, NIRS can be implemented during pharmaceutical development, in production for process monitoring or in quality control laboratories. This review focuses on chemometric techniques and pharmaceutical NIRS applications. The following topics are covered: qualitative analyses, quantitative methods and on-line applications. Theoretical and practical aspects are described with pharmaceutical examples of NIRS applications.
Roggo
Yves
Y
F. Hoffmann-La Roche Ltd., Basel, Switzerland. yves.roggo@roche.com
Chalus
Pascal
P
Maurer
Lene
L
Lema-Martinez
Carmen
C
Edmond
Aurélie
A
Jent
Nadine
N
D015195:Drug Design; D006801:Humans; D004364:Pharmaceutical Preparations / Q000032:analysis*; D019265:Spectroscopy, Near-Infrared; D013678:Technology, Pharmaceutical / Q000379:methods* / Q000639:trends
D004364:Pharmaceutical Preparations