title: Outbreak of chikungunya on Reunion Island: early clinical and laboratory features in 157 adult patients.
abstract: BACKGROUND
  Chikungunya is a reemerging disease. In 2005-2006, a severe outbreak occurred on Reunion Island in the southwestern part of the Indian Ocean. Other islands in this area were affected during the same period.
  
  
  METHODS
  Adult patients with acute chikungunya (defined as onset of fever and/or polyarthralgia in the 5 days preceding consultation) and laboratory-confirmed chikungunya who were referred to Groupe Hospitalier Sud Reunion during the period from March 2005 through April 2006 were included in this retrospective study. Their clinical and laboratory features are reported.
  
  
  RESULTS
  Laboratory-confirmed acute chikungunya was documented in 157 patients. The mean age of patients was 57.9 years, and the ratio of male to female patients was 1.24 : 1. Sixty percent of patients had at least 1 comorbidity. Ninety-seven patients (61.8%) were hospitalized, and 60 (38.2%) were treated as outpatients. Five fatalities were reported. One hundred fifty-one patients (96.1%) experienced polyarthralgia, and 129 (89%) experienced fever. Gastrointestinal symptoms were reported by 74 patients (47.1%), and skin rash was reported by 63 (40.1%). Hemorrhagic signs were rare. Lymphopenia and hypocalcemia were the prominent laboratory findings. Severe thrombocytopenia was rarely observed.
  
  
  CONCLUSIONS
  Chikungunya virus can be responsible for explosive outbreaks of disease. Polyarthralgia and fever are the 2 main clinical features. In this era of travel and globalization, chikungunya should be considered in the differential diagnosis of febrile polyarthralgia with an abrupt onset.
authors.affiliation: Service de Pneumologie et Maladies Infectieuses, Groupe Hospitalier Sud Reunion, Saint Pierre, La Reunion, France. gianu.borg@wanadoo.fr
authors.forename: Gianandrea
authors.initials: G
authors.lastname: Borgherini
authors.forename: Patrice
authors.initials: P
authors.lastname: Poubeau
authors.forename: Frederik
authors.initials: F
authors.lastname: Staikowsky
authors.forename: Manuella
authors.initials: M
authors.lastname: Lory
authors.forename: Nathalie
authors.initials: N
authors.lastname: Le Moullec
authors.forename: Jean Philippe
authors.initials: JP
authors.lastname: Becquart
authors.forename: Catherine
authors.initials: C
authors.lastname: Wengling
authors.forename: Alain
authors.initials: A
authors.lastname: Michault
authors.forename: Fabrice
authors.initials: F
authors.lastname: Paganin
mesh_terms: D000328:Adult; D018354:Alphavirus Infections / Q000175:diagnosis* / Q000453:epidemiology* / Q000821:virology; D002646:Chikungunya virus / Q000302:isolation & purification*; D015897:Comorbidity; D004196:Disease Outbreaks; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D017508:Reunion / Q000453:epidemiology