Ultrasensitive p24 antigen assay for diagnosis of perinatal human immunodeficiency virus type 1 infection.
We evaluated an ultrasensitive p24 antigen enzyme immunosorbent assay on 802 plasma specimens from 582 infants and children of 0 to 180 days of age. Overall sensitivity and specificity were 91.7% and 98.5%, respectively. After exclusion of infants of less than 7 days of age, the sensitivity and specificity were 93.7% and 98.3%, respectively.
Fiscus
Susan A
SA
University of North Carolina at Chapel Hill, Department of Microbiology and Immunology, Chapel Hill, North Carolina, USA. fiscussa@med.unc.edu
Wiener
Jeffrey
J
Abrams
Elaine J
EJ
Bulterys
Marc
M
Cachafeiro
Ada
A
Respess
Richard A
RA
D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods*; D016655:HIV Core Protein p24 / Q000032:analysis* / Q000097:blood*; D015658:HIV Infections / Q000175:diagnosis* / Q000453:epidemiology; D015497:HIV-1; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000175:diagnosis* / Q000453:epidemiology; D012680:Sensitivity and Specificity; D014481:United States
D016655:HIV Core Protein p24