title: Synthesis of two diastereomeric C1-C22 fragments of spirastrellolide A.
abstract: The optimisation of a synthetic strategy towards the ABC segment of the cytotoxic macrolide spirastrellolide A is reported, together with its application to the synthesis of two diastereomeric C(1)-C(22) fragments for stereochemical correlation purposes with a putative spirastrellolide degradation product.
authors.affiliation: University Chemical Laboratory, Lensfield Road, Cambridge, UK. ip100@cam.ac.uk
authors.forename: Ian
authors.initials: I
authors.lastname: Paterson
authors.forename: Edward A
authors.initials: EA
authors.lastname: Anderson
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Dalby
authors.forename: Julien
authors.initials: J
authors.lastname: Genovino
authors.forename: Jong Ho
authors.initials: JH
authors.lastname: Lim
authors.forename: Christian
authors.initials: C
authors.lastname: Moessner
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000138:chemical synthesis* / Q000737:chemistry; D001895:Boron / Q000737:chemistry; D018360:Crystallography, X-Ray; D007202:Indicators and Reagents; D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D010084:Oxidation-Reduction; D011161:Porifera / Q000737:chemistry; D013141:Spiro Compounds; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D000903:Antibiotics, Antineoplastic; D007202:Indicators and Reagents; D018942:Macrolides; D013141:Spiro Compounds; C475125:spirastrellolide A; D001895:Boron