title: Requirement of bic/microRNA-155 for normal immune function.
abstract: MicroRNAs are a class of small RNAs that are increasingly being recognized as important regulators of gene expression. Although hundreds of microRNAs are present in the mammalian genome, genetic studies addressing their physiological roles are at an early stage. We have shown that mice deficient for bic/microRNA-155 are immunodeficient and display increased lung airway remodeling. We demonstrate a requirement of bic/microRNA-155 for the function of B and T lymphocytes and dendritic cells. Transcriptome analysis of bic/microRNA-155-deficient CD4+ T cells identified a wide spectrum of microRNA-155-regulated genes, including cytokines, chemokines, and transcription factors. Our work suggests that bic/microRNA-155 plays a key role in the homeostasis and function of the immune system.
authors.affiliation: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
authors.forename: Antony
authors.initials: A
authors.lastname: Rodriguez
authors.forename: Elena
authors.initials: E
authors.lastname: Vigorito
authors.forename: Simon
authors.initials: S
authors.lastname: Clare
authors.forename: Madhuri V
authors.initials: MV
authors.lastname: Warren
authors.forename: Philippe
authors.initials: P
authors.lastname: Couttet
authors.forename: Dalya R
authors.initials: DR
authors.lastname: Soond
authors.forename: Stijn
authors.initials: S
authors.lastname: van Dongen
authors.forename: Russell J
authors.initials: RJ
authors.lastname: Grocock
authors.forename: Partha P
authors.initials: PP
authors.lastname: Das
authors.forename: Eric A
authors.initials: EA
authors.lastname: Miska
authors.forename: David
authors.initials: D
authors.lastname: Vetrie
authors.forename: Klaus
authors.initials: K
authors.lastname: Okkenhaug
authors.forename: Anton J
authors.initials: AJ
authors.lastname: Enright
authors.forename: Gordon
authors.initials: G
authors.lastname: Dougan
authors.forename: Martin
authors.initials: M
authors.lastname: Turner
authors.forename: Allan
authors.initials: A
authors.lastname: Bradley
mesh_terms: D020413:3' Untranslated Regions; D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D016207:Cytokines / Q000096:biosynthesis; D003713:Dendritic Cells / Q000276:immunology*; D005786:Gene Expression Regulation; D018390:Gene Targeting; D006706:Homeostasis; D007107:Immune System / Q000502:physiology*; D007074:Immunoglobulin G / Q000096:biosynthesis; D008168:Lung / Q000473:pathology; D008171:Lung Diseases / Q000276:immunology / Q000473:pathology; D008213:Lymphocyte Activation; D051379:Mice; D035683:MicroRNAs / Q000235:genetics / Q000502:physiology*; D020411:Oligonucleotide Array Sequence Analysis; D051257:Proto-Oncogene Proteins c-maf / Q000235:genetics / Q000502:physiology; D012481:Salmonella Infections, Animal / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D018417:Th1 Cells / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology; D014611:Vaccination
chemical_list: D020413:3' Untranslated Regions; D016207:Cytokines; D007074:Immunoglobulin G; D035683:MicroRNAs; D051257:Proto-Oncogene Proteins c-maf