[The combination of thio-tepa and 5 fluorouracil as a palliative therapy for breast cancer].
Over a six-year period, a total of 177 patients with far-advanced breast carcinoma have been submitted by the authors to 200 chemotherapeutical cycles combining Thio-TEPA and 5 fluorouracile according to a well-defined scheme. The efficiency was but minimally enhanced, as compared with separate use of these two drugs. According to the authors, however, the principle of multiple chemotherapy should not be questioned. In fact, the problem to be considered is connected with the indications of hormone therapy and chemotherapy, respectively.
Chauvergne
J
J
Fondation Bergonié, Bordeaux Cedex, France.
Hoerni
B
B
Hoerni-Simon
G
G
Durand
M
M
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy*; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage*; D006801:Humans; D008875:Middle Aged; D010166:Palliative Care / Q000379:methods*; D011446:Prospective Studies; D013852:Thiotepa / Q000008:administration & dosage*
D013852:Thiotepa; D005472:Fluorouracil