Radiation sterilisation of advanced drug-device combination products.
Sterilisation of drug-device combination products presents unique challenges and demands some new thinking. Issues such as dose setting and controlling free radicals for these ultraclean, high-cost products are discussed together with the future advancements required for their efficient terminal sterilisation.
Masefield
J
J
STERIS Isomedix and iiA, Whippany, New Jersey, USA. john_masefield@steris.com
Brinston
R
R
D001672:Biocompatible Materials / Q000528:radiation effects*; D004340:Drug Contamination / Q000517:prevention & control*; D004343:Drug Implants / Q000528:radiation effects*; D004866:Equipment Contamination / Q000517:prevention & control*; D011829:Radiation Dosage; D011839:Radiation, Ionizing; D013242:Sterilization / Q000379:methods*
D001672:Biocompatible Materials; D004343:Drug Implants