title: Prevention of community-acquired pneumonia among a cohort of hospitalized elderly: benefit due to influenza and pneumococcal vaccination not demonstrated.
abstract: Benefits from influenza and 23-valent pneumococcal polysaccharide (23vPPV) vaccines against invasive pneumococcal disease and laboratory confirmed influenza have been well documented. However, their effectiveness against pneumonia remains controversial for community-based elderly > or = 65 years. Using a case-cohort design we examined incremental VE of 23vPPV over and above influenza vaccine against hospitalization with community-acquired pneumonia (HCAP) in two large Australian hospitals. 1952 cases (ICD-10-AM codes for pneumonia: J10-J18) and 2927 randomly selected cohort subjects were studied. Vaccination status was confirmed by providers. Benefit against HCAP was not demonstrated in multivariate analysis for influenza vaccine compared with neither vaccine (RR 1.02, 95%CI 0.84-1.20) or for both vaccines compared with influenza vaccine (RR 0.98, 95%CI 0.81-1.18). The current program of funding these vaccines for the elderly is not having a discernable impact on HCAP in this setting.
authors.affiliation: Department of Paediatrics, University of Melbourne, Royal Children's Hospital, Flemington Rd, Parkville, Victoria 3052, Australia. saskull@unimelb.edu.au
authors.forename: Susan A
authors.initials: SA
authors.lastname: Skull
authors.forename: Ross M
authors.initials: RM
authors.lastname: Andrews
authors.forename: Graham B
authors.initials: GB
authors.lastname: Byrnes
authors.forename: Heath A
authors.initials: HA
authors.lastname: Kelly
authors.forename: Terence M
authors.initials: TM
authors.lastname: Nolan
authors.forename: Graham V
authors.initials: GV
authors.lastname: Brown
authors.forename: Donald A
authors.initials: DA
authors.lastname: Campbell
mesh_terms: D000368:Aged; D015331:Cohort Studies; D017714:Community-Acquired Infections / Q000517:prevention & control*; D005260:Female; D006760:Hospitalization; D006801:Humans; D007252:Influenza Vaccines / Q000276:immunology*; D008297:Male; D022242:Pneumococcal Vaccines / Q000276:immunology*; D011014:Pneumonia / Q000517:prevention & control*; D014611:Vaccination
chemical_list: D007252:Influenza Vaccines; D022242:Pneumococcal Vaccines