title: Prognostic value of preoperative peripheral blood monocyte count in patients with colorectal liver metastasis after liver resection.
abstract: Prognostic values of leukocyte subset counts in peripheral blood of cancer patients have not yet been fully investigated. We retrospectively examined the relation between preoperative absolute counts of peripheral blood leukocyte subsets and clinicopathologic factors and long-term prognosis in 97 patients with liver metastasis from colorectal cancer who underwent hepatic resection. Median preoperative peripheral blood leukocyte subset counts were as follows: neutrophils 3148/mm3; lymphocytes 1574/mm3; monocytes 380/mm3. Univariate analysis indicated significantly worse 5-year cancer-related survival for patients with a peripheral blood monocyte count >300/mm3 (67.5%) than for patients with a count <or=300/mm3 (36.8%). Multivariate analysis showed a preoperative peripheral blood monocyte count >300/mm3 and preoperative CEA level (>10 ng/ml) to be independent predictive factors for cancer-related survival after hepatic resection. The preoperative peripheral monocyte count correlated positively with white blood cell and neutrophil counts, but not with the tumor number, interval between colorectal and hepatic surgery, or preoperative serum CEA level. Our findings indicate that a preoperative absolute peripheral blood monocyte count >300/mm3 is an independent predictive factor for cancer-related survival of patients with colorectal liver metastasis who have undergone hepatic resection.
authors.affiliation: Department of Surgery I, Oita University Faculty of Medicine, 1-1 Hasama-mach, Yufu, Oita 879-5593, Japan. sasakia@med.oita-u.ac.jp
authors.forename: Atsushi
authors.initials: A
authors.lastname: Sasaki
authors.forename: Seiichiro
authors.initials: S
authors.lastname: Kai
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Endo
authors.forename: Kentaro
authors.initials: K
authors.lastname: Iwaki
authors.forename: Hiroki
authors.initials: H
authors.lastname: Uchida
authors.forename: Masayuki
authors.initials: M
authors.lastname: Tominaga
authors.forename: Ryoki
authors.initials: R
authors.lastname: Okunaga
authors.forename: Kohei
authors.initials: K
authors.lastname: Shibata
authors.forename: Masayuki
authors.initials: M
authors.lastname: Ohta
authors.forename: Seigo
authors.initials: S
authors.lastname: Kitano
mesh_terms: D002272:Carcinoembryonic Antigen / Q000097:blood; D003110:Colonic Neoplasms / Q000097:blood / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D005544:Forecasting; D006498:Hepatectomy; D006801:Humans; D007958:Leukocyte Count; D008113:Liver Neoplasms / Q000097:blood / Q000556:secondary* / Q000601:surgery; D008137:Longitudinal Studies; D008207:Lymphatic Metastasis / Q000473:pathology; D018655:Lymphocyte Count; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000473:pathology*; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D009367:Neoplasm Staging; D009504:Neutrophils / Q000473:pathology; D011300:Preoperative Care; D011379:Prognosis; D012004:Rectal Neoplasms / Q000097:blood / Q000473:pathology*; D012189:Retrospective Studies; D015996:Survival Rate
chemical_list: D002272:Carcinoembryonic Antigen