title: Effects of Applephenon and ascorbic acid on physical fatigue.
abstract: OBJECTIVE
  We examined the effects of Applephenon and ascorbic acid administration on physical fatigue.
  
  
  METHODS
  In a double-blinded, placebo-controlled, three-way crossover design, 18 healthy volunteers were randomized to oral Applephenon (1200 mg/d), ascorbic acid (1000 mg/d), or placebo for 8 d. The fatigue-inducing physical task consisted of workload trials on a bicycle ergometer at fixed workloads for 2 h on two occasions. During the test, subjects performed non-workload trials with maximum velocity for 10 s at 30 min (30-min trial) after the start of the test and 30 min before the end of the test (210-min trial).
  
  
  RESULTS
  The change in maximum velocity between the 30- and 210-min trials was higher in the group given Applephenon than in the group given placebo; ascorbic acid had no effect.
  
  
  CONCLUSIONS
  These results suggest that Applephenon attenuates physical fatigue, whereas ascorbic acid does not.
authors.affiliation: Department of Physiology, Osaka City University Graduate School of Medicine, Osaka, Japan.
authors.forename: Suzuka
authors.initials: S
authors.lastname: Ataka
authors.forename: Masaaki
authors.initials: M
authors.lastname: Tanaka
authors.forename: Satoshi
authors.initials: S
authors.lastname: Nozaki
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Mizuma
authors.forename: Kei
authors.initials: K
authors.lastname: Mizuno
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Tahara
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Sugino
authors.forename: Tomoko
authors.initials: T
authors.lastname: Shirai
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Kajimoto
authors.forename: Hirohiko
authors.initials: H
authors.lastname: Kuratsune
authors.forename: Osami
authors.initials: O
authors.lastname: Kajimoto
authors.forename: Yasuyoshi
authors.initials: Y
authors.lastname: Watanabe
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000494:pharmacology*; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005260:Female; D005419:Flavonoids / Q000494:pharmacology*; D006801:Humans; D008297:Male; D027845:Malus / Q000737:chemistry; D018763:Muscle Fatigue / Q000187:drug effects* / Q000502:physiology; D010101:Oxygen Consumption; D010636:Phenols / Q000494:pharmacology*; D010807:Physical Endurance / Q000187:drug effects* / Q000502:physiology; D059808:Polyphenols
chemical_list: D000975:Antioxidants; D005419:Flavonoids; D010636:Phenols; D059808:Polyphenols; D001205:Ascorbic Acid