[Fibrates and markers of inflammation].
Inflammatory processes have important roles in the etiology of atherosclerosis. Several studies have shown that elevated plasma levels of C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), adhesions molecules, monocyte chemoattractant protein-1 (MCP-1) are associated with the risk of coronary heart disease. Fibrates, agonists of peroxisome proliferator-activated receptors alpha (PPARalpha), act to modulate the expression of key genes of lipid transport and metabolism in the liver and adipose tissue. Besides the hipolipemic effects they exert pleiotropic, anti-inflammatory properties downregulating expression of genes encoding acute phase proteins and inflammatory cytokines. In this article, we briefly review the clinical trial data on the effects of fibrates on the inflammatory markers.
Broncel
Marlena
M
Department of Internal Diseases with Clinical Pharmacology and Therapy Monitoring Unit, Medical University of Łódź, Poland. ttm@ttm.org.pl
D050197:Atherosclerosis / Q000097:blood / Q000188:drug therapy; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis / Q000187:drug effects; D008076:Cholesterol, HDL / Q000097:blood / Q000187:drug effects; D008078:Cholesterol, LDL / Q000097:blood / Q000187:drug effects; D002995:Clofibric Acid / Q000627:therapeutic use*; D016207:Cytokines / Q000097:blood / Q000187:drug effects; D005340:Fibrinogen / Q000032:analysis / Q000187:drug effects; D006801:Humans; D000960:Hypolipidemic Agents / Q000627:therapeutic use*; D007249:Inflammation / Q000097:blood* / Q000188:drug therapy*; D015850:Interleukin-6 / Q000097:blood; D053858:Metabolic Networks and Pathways; D047493:PPAR alpha / Q000819:agonists* / Q000502:physiology
D015415:Biomarkers; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D016207:Cytokines; D000960:Hypolipidemic Agents; D015850:Interleukin-6; D047493:PPAR alpha; D002995:Clofibric Acid; D005340:Fibrinogen; D002097:C-Reactive Protein