title: Spinal atypical teratoid/rhabdoid tumor in a 7-year-old boy.
abstract: Reported herein is an unusual case of atypical teratoid/ rhabdoid tumor (AT/RT) of the lumbar spine with an intradural extramedullary location in a 7-year-old boy. Histologically, this tumor contained rhabdoid cells, pale cells, and sickle-shaped embracing cells without primitive neuroectodermal tumor (PNET), mesenchymal or epithelial components. Immunohistochemical staining showed that these tumor cells react positively for epithelial membrane antigen (EMA), vimentin, cytokeratin (AE1/AE3), CD99 and neurofilament protein, but negatively for INI1 antibody. Chromosome 22q deletion was demonstrated on fluorescence in situ hybridization.
authors.affiliation: Department of Pathology, Taichung Veterans General Hospital, College of Medicine, Chung Shan Medical University, Taichung, Taiwan. chii.shuenn@msa.hinet.net
authors.forename: Chii-Shuenn
authors.initials: CS
authors.lastname: Yang
authors.forename: Yee-Jee
authors.initials: YJ
authors.lastname: Jan
authors.forename: John
authors.initials: J
authors.lastname: Wang
authors.forename: Chiung-Chyi
authors.initials: CC
authors.lastname: Shen
authors.forename: Clayton C C
authors.initials: CC
authors.lastname: Chen
authors.forename: Ming
authors.initials: M
authors.lastname: Chen
mesh_terms: D002648:Child; D002872:Chromosome Deletion; D002892:Chromosomes, Human, Pair 22; D017809:Fatal Outcome; D006801:Humans; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D008161:Lumbosacral Region; D008279:Magnetic Resonance Imaging; D008297:Male; D018335:Rhabdoid Tumor / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D013125:Spinal Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D013724:Teratoma / Q000235:genetics / Q000378:metabolism / Q000473:pathology*