title: T-cell depletion prevents from bronchiolitis obliterans and bronchiolitis obliterans with organizing pneumonia after allogeneic hematopoietic stem cell transplantation with related donors.
abstract: Bronchiolitis obliterans (BO) and bronchiolitis obliterans organizing pneumonia (BOOP) are late-onset non-infectious pulmonary complications (LONIPCs) following allogeneic hematopoietic stem cell transplantation (HSCT). In the present study 10 of 197 conventionally prepared stem cell recipients developed BOOP after 365 days and 6 patients developed BO 333 days post-transplant. No BOOP or BO was diagnosed following T-cell depletion (p<0.05). Chronic GVHD was ascertained in all BOOP patients and appeared significantly (p<0,001) more frequent in the conventional transplant group. The data confirm a strong association between T-cell activity, chronic GVHD, BO and BOOP and point out the impact of T lymphocytes in the pathomechanism of BOOP.
authors.affiliation: Department of bone marrow transplantation, University Hospital of Essen, Essen, Germany. markus.ditschkowski@uni-essen.de
authors.forename: Markus
authors.initials: M
authors.lastname: Ditschkowski
authors.forename: Ahmet H
authors.initials: AH
authors.lastname: Elmaagacli
authors.forename: Rudolf
authors.initials: R
authors.lastname: Trenschel
authors.forename: Rudolf
authors.initials: R
authors.lastname: Peceny
authors.forename: Michael
authors.initials: M
authors.lastname: Koldehoff
authors.forename: Claudia
authors.initials: C
authors.lastname: Schulte
authors.forename: Dietrich W
authors.initials: DW
authors.lastname: Beelen
mesh_terms: D000328:Adult; D000368:Aged; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D001989:Bronchiolitis Obliterans / Q000209:etiology / Q000235:genetics / Q000276:immunology / Q000517:prevention & control*; D018549:Cryptogenic Organizing Pneumonia / Q000209:etiology / Q000235:genetics / Q000276:immunology / Q000517:prevention & control*; D005260:Female; D006086:Graft vs Host Disease / Q000209:etiology / Q000517:prevention & control; D006801:Humans; D053208:Kaplan-Meier Estimate; D008212:Lymphocyte Depletion / Q000706:statistics & numerical data; D017710:Lymphocyte Transfusion; D008297:Male; D008875:Middle Aged; D053473:Nod2 Signaling Adaptor Protein / Q000235:genetics; D036102:Peripheral Blood Stem Cell Transplantation / Q000009:adverse effects*; D011183:Postoperative Complications / Q000209:etiology / Q000401:mortality / Q000517:prevention & control*; D016016:Proportional Hazards Models; D012131:Respiratory Insufficiency / Q000401:mortality; D012189:Retrospective Studies; D012737:Sex Factors; D013601:T-Lymphocytes / Q000276:immunology / Q000637:transplantation; D014019:Tissue Donors; D051197:Toll-Like Receptor 4 / Q000235:genetics; D019172:Transplantation Conditioning / Q000009:adverse effects*; D014184:Transplantation, Homologous
chemical_list: C429018:NOD2 protein, human; D053473:Nod2 Signaling Adaptor Protein; C495345:TLR4 protein, human; D051197:Toll-Like Receptor 4