title: A 59-kD renal antigen as a new target for rapidly progressive glomerulonephritis.
abstract: Anti-glomerular basement membrane (anti-GBM) antibodies are the hallmark of anti-GBM disease, which is characterized by rapidly progressive glomerulonephritis. We describe the case of a 58-year-old woman who presented with rapidly progressive glomerulonephritis with typical anti-GBM staining found by means of direct immunofluorescence microscopy, associated with linear immunoglobin G deposits on tubules. Serum analysis showed circulating anti-tubular basement membrane antibodies, but failed to detect anti-GBM antibodies. Immunoblotting showed that serum antibodies reacted with a 59-kd antigen found along both the GBM and tubular basement membrane.
authors.affiliation: Institut de recherche en néphrologie et transplantation d'Ile de France, Henri Mondor Hospital, Paris, France. vincent.audard@hmn.ap-hop-paris.fr <vincent.audard@hmn.ap-hop-paris.fr>
authors.forename: Vincent
authors.initials: V
authors.lastname: Audard
authors.forename: Thomas
authors.initials: T
authors.lastname: Hellmark
authors.forename: Khalil
authors.initials: K
authors.lastname: El Karoui
authors.forename: Laure Hélène
authors.initials: LH
authors.lastname: Noël
authors.forename: Agathe
authors.initials: A
authors.lastname: Pardon
authors.forename: Dominique
authors.initials: D
authors.lastname: Desvaux
authors.forename: Guy
authors.initials: G
authors.lastname: Touchard
authors.forename: Philippe
authors.initials: P
authors.lastname: Remy
authors.forename: Philippe
authors.initials: P
authors.lastname: Lang
authors.forename: Djillali
authors.initials: D
authors.lastname: Sahali
mesh_terms: D019867:Anti-Glomerular Basement Membrane Disease / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology*; D001324:Autoantigens / Q000276:immunology / Q000378:metabolism*; D018450:Disease Progression; D005260:Female; D006801:Humans; D007684:Kidney Tubules / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged
chemical_list: D001324:Autoantigens; D008775:Methylprednisolone