title: Hereditary factors in multiple primary malignancies associated with lung cancer.
abstract: OBJECTIVE
  There are differences between lung cancer alone and multiple primary malignancies associated with lung cancer (MPMLC) in terms of clinical characteristics. However, the importance of these differences has not yet been clarified.
  
  
  METHODS
  Univariate and multivariate analyses were performed on 123 patients with MPMLC and 815 patients with lung cancer alone who underwent operative procedures for lung cancer from August 1982 to March 2004.
  
  
  RESULTS
  Age, number of family with a family history of other malignancies except for smoking-related cancers, and pathological early stage of lung cancer were significantly high in patients with MPMLC based on univariate analyses (P < 0.0001, P < 0.05, and P < 0.05, respectively). Age and family history of malignancy were thus found to be significant factors based on a multivariate analysis.
  
  
  CONCLUSIONS
  MPMLC demonstrated a significant association with advanced age and stronger hereditary factors in comparison with lung cancer alone, indicating the need for different approaches to properly manage and follow up risk patients.
authors.affiliation: Department of Surgery, Nippon Medical School Musashikosugi Hospital, Kawasaki, Kanagawa 211-8533, Japan.
authors.forename: Shuji
authors.initials: S
authors.lastname: Haraguchi
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Koizumi
authors.forename: Masafumi
authors.initials: M
authors.lastname: Hioki
authors.forename: Takao
authors.initials: T
authors.lastname: Hisayoshi
authors.forename: Tomomi
authors.initials: T
authors.lastname: Hirata
authors.forename: Kazuo
authors.initials: K
authors.lastname: Shimizu
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D003110:Colonic Neoplasms / Q000235:genetics; D005260:Female; D006801:Humans; D016015:Logistic Models; D008175:Lung Neoplasms / Q000453:epidemiology / Q000235:genetics / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009378:Neoplasms, Multiple Primary / Q000453:epidemiology / Q000235:genetics*; D012907:Smoking / Q000453:epidemiology; D013274:Stomach Neoplasms / Q000235:genetics