title: Ciliary body melanoma with limited nodular extrascleral extension and diffuse iris-angle infiltration treated by whole anterior segment plaque radiotherapy.
abstract: BACKGROUND
  Primary uveal malignant melanoma of the ciliary body associated with nodular extrascleral extension, diffuse iris-angle infiltration, and secondary glaucoma is usually treated by prompt enucleation. We report a patient with ciliary body melanoma associated with nodular extrascleral extension and diffuse infiltration of the iris and angle treated conservatively because the fellow eye was blind.
  
  
  METHODS
  The clinical features and surgical management of a melanoma of the ciliary body with extrascleral extension and diffuse infiltration of the iris and angle are presented. The tumor was treated with focal I-125 plaque radiotherapy followed by supplemental whole anterior segment I-125 plaque radiotherapy.
  
  
  RESULTS
  The patient has been followed for over 2.5 years since the initial plaque radiotherapy and over 1.5 years since the supplemental whole anterior segment radiotherapy. His visual acuity is correctable to 20/40 OD and there is no evidence of metastatic disease. His glaucoma is well controlled following trabeculectomy and tube shunt procedure.
  
  
  CONCLUSIONS
  Whole anterior segment plaque radiotherapy for ciliary body melanoma with diffuse iris-angle infiltration provided palliative local tumor control without significant local complications through available follow-up.
authors.affiliation: University of Cincinnati College of Medicine, Cincinnati, OH, USA.
authors.forename: Michael E
authors.initials: ME
authors.lastname: Gray
authors.forename: Zélia M
authors.initials: ZM
authors.lastname: Corrêa
authors.forename: James J
authors.initials: JJ
authors.lastname: Augsburger
authors.forename: William
authors.initials: W
authors.lastname: Barrett
mesh_terms: D000368:Aged; D001918:Brachytherapy / Q000379:methods*; D002924:Ciliary Body / Q000473:pathology*; D005500:Follow-Up Studies; D015812:Glaucoma, Angle-Closure / Q000209:etiology / Q000601:surgery; D006801:Humans; D015811:Iris Neoplasms / Q000150:complications / Q000473:pathology* / Q000532:radiotherapy; D008297:Male; D008545:Melanoma / Q000150:complications / Q000473:pathology* / Q000532:radiotherapy; D009361:Neoplasm Invasiveness; D015422:Scleral Diseases / Q000150:complications / Q000473:pathology* / Q000532:radiotherapy; D014130:Trabeculectomy; D014604:Uveal Neoplasms / Q000150:complications / Q000473:pathology* / Q000532:radiotherapy