Mild and neutral deprotections catalyzed by cerium(IV) ammonium nitrate.
The development of a novel, chemoselective, and catalytic deprotection methodology that proceeds under mild and neutral conditions is described, and its mechanism of action is analyzed in some detail. The scope, limitations, and advantages of this protocol are discussed. Selected applications in synthesis are also highlighted.
Maulide
Nuno
N
Université catholique de Louvain, Département de Chimie, Bâtiment Lavoisier, Place Louis Pasteur 1, 1348 Louvain-la-Neuve, Belgium.
Vanherck
Jean-Christophe
JC
Gautier
Arnaud
A
Markó
István E
IE
D002384:Catalysis; D002563:Cerium / Q000737:chemistry*; D009566:Nitrates / Q000737:chemistry*; D009930:Organic Chemicals / Q000138:chemical synthesis
D009566:Nitrates; D009930:Organic Chemicals; D002563:Cerium; C006568:ammonium nitrate