title: A novel strategy for bioconjugation: synthesis and preliminary evaluation with amphotericin B.
abstract: A novel linker strategy is presented based on a double reductive amination of a dialdehyde to the amine of the amphotericin B mycosamine sugar and the biological activity of a series of conjugates is compared to the native amphotericin B.
authors.affiliation: Laboratorium für Organische Chemie, ETH Hönggerberg, 8093, Zürich, Switzerland.
authors.forename: Andreas
authors.initials: A
authors.lastname: Zumbuehl
authors.forename: Pasquale
authors.initials: P
authors.lastname: Stano
authors.forename: Marc
authors.initials: M
authors.lastname: Sohrmann
authors.forename: Mathias
authors.initials: M
authors.lastname: Peter
authors.forename: Peter
authors.initials: P
authors.lastname: Walde
authors.forename: Erick M
authors.initials: EM
authors.lastname: Carreira
mesh_terms: D000577:Amides / Q000737:chemistry; D000586:Amination; D000666:Amphotericin B / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*; D000935:Antifungal Agents / Q000737:chemistry* / Q000494:pharmacology*; D001710:Biotin / Q000737:chemistry; D008081:Liposomes / Q000378:metabolism; D010713:Phosphatidylcholines / Q000378:metabolism; D011188:Potassium / Q000378:metabolism; D011199:Potentiometry
chemical_list: D000577:Amides; D000935:Antifungal Agents; D008081:Liposomes; D010713:Phosphatidylcholines; D001710:Biotin; D000666:Amphotericin B; D011188:Potassium; C028694:1-palmitoyl-2-oleoylphosphatidylcholine