title: Polychlorinated dibenzo-p-dioxins and the human immune system: 4 studies on two Spanish families with increased body burdens of highly chlorinated PCDDs.
abstract: The consequences of exposure of people to highly chlorinated polychlorodibenzo-p-dioxins (PCDDs) are much less known than those of TCDD. We report on levels of PCDDs (and PCDFs) in 13 members of two families poisoned by contaminated cooking oil. Originally, all persons displayed chloracne as an early symptom. Persisting hexa- and higher chlorinated PCDDs could be analysed many years after exposure. Highest values found in blood lipids were: OCDD 660,000 pg/g; HpCDD 58,000 pg/g; HxCDDs: 3500 pg/g. None of the participants exhibited increased TCDD levels at the time of study. During a period of 6 years, HpCDD and OCDD disappeared from the blood lipids much faster in persons exposed as children or young adults, than from lipids of their parents. Surface receptors on blood lymphocytes of the members of the two families and the proliferative capacity of these blood cells in the presence of typical stimulants were analysed. Even in family members with the highest body burdens of hexa- to octachlorinated PCDDs we could not detect pronounced changes from a reference population with respect to the immunological markers. Minor deviations of levels of some receptors in a few, but not all, highly exposed persons suggested a similar trend to those reported in previous studies of persons with body burdens of > or =3000 pg TCDD/g blood lipids. An increase in the number of total blood lymphocytes in some subjects exposed as children may have similarity with highly TCDD-exposed children in Seveso.
authors.affiliation: MRC Toxicology Unit, Hodgkin Building, University of Leicester, Lancaster Road, Leicester LE1 9HN, UK. ags5@leicester.ac.uk <ags5@leicester.ac.uk>
authors.forename: Andrew G
authors.initials: AG
authors.lastname: Smith
authors.forename: Marriane
authors.initials: M
authors.lastname: Hansson
authors.forename: Antonio
authors.initials: A
authors.lastname: Rodriguez-Pichardo
authors.forename: Ana
authors.initials: A
authors.lastname: Ferrer-Dufol
authors.forename: Reinhard T
authors.initials: RT
authors.lastname: Neubert
authors.forename: Jessie R
authors.initials: JR
authors.lastname: Webb
authors.forename: Christopher
authors.initials: C
authors.lastname: Rappe
authors.forename: Diether
authors.initials: D
authors.lastname: Neubert
mesh_terms: D000293:Adolescent; D000328:Adult; D015703:Antigens, CD / Q000032:analysis; D001774:Blood Chemical Analysis; D001822:Body Burden; D002648:Child; D054506:Chloracne; D004042:Dietary Fats, Unsaturated; D005192:Family Health; D005260:Female; D006801:Humans; D007107:Immune System / Q000187:drug effects*; D008214:Lymphocytes / Q000737:chemistry / Q000276:immunology; D008297:Male; D008875:Middle Aged; D000072317:Polychlorinated Dibenzodioxins / Q000031:analogs & derivatives* / Q000097:blood / Q000633:toxicity; D011971:Receptors, Immunologic / Q000032:analysis; D013030:Spain
chemical_list: D015703:Antigens, CD; D004042:Dietary Fats, Unsaturated; D000072317:Polychlorinated Dibenzodioxins; D011971:Receptors, Immunologic