Atherosclerosis in diabetes mellitus: role of inflammation.
Inflammation plays a central role in the pathophysiology of atherosclerosis, starting from initiation, through progression and ultimately the thrombotic complications of atherosclerosis. Diabetes mellitus is a major risk factor for atherosclerosis. Hyperglycemia-induced endothelial dysfunctions, along with hypercoagulable potential of diabetes mellitus, accelerate the process of atherothrombotic complications. Therefore, clinically feasible markers to monitor subtle systemic inflammatory burden and specific add-on therapy for the same constitute need of the present day. The understanding of the concept of inflammation in diabetes-accelerated atherosclerosis can be used practically to predict future cardiovascular risk by evaluating inflammatory biomarkers and to design clinical trials making inflammation as a therapeutic target.
Maiti
Rituparna
R
Department of Pharmacology, Prathima Institute of Medical Sciences, Karimnagar andhra Pradesh, India. rituparnamaiti@rediffmail.com
Agrawal
Neeraj K
NK
D050197:Atherosclerosis / Q000209:etiology* / Q000503:physiopathology; D015415:Biomarkers; D048909:Diabetes Complications / Q000503:physiopathology*; D018450:Disease Progression; D004730:Endothelium, Vascular / Q000503:physiopathology*; D006801:Humans; D007249:Inflammation / Q000503:physiopathology*; D018384:Oxidative Stress; D012307:Risk Factors
D015415:Biomarkers