Regulation and function of H3K9 methylation.
First histone lysine methyltransferase (HLMTase) was discovered in 2000. Since then, there are reports of dozens of novel HLMTases in different eukaryotes including plant, fungus, insect, nematode and vertebrate. The enzymes and their specific histone-lysine modifications have enormous impacts on the regulation of chromatin structure and function. Furthermore, various histone methyl-lysine demethylases (HLDMases) have been identified recently. In this chapter, histone H3 lysine 9 specific methyltransferases will be discussed as model enzymes involved in the regulation of chromatin function
Shinkai
Yoichi
Y
Experimental Research Center for Infectious Diseases, Institute for Virus Research, Kyoto University, 53 Kawara-cho, Shogoin, Sakyo-ku, Kyoto, Kyoto 606-8507, Japan. yshinkai@virus.kyoto-u.ac.jp
D000818:Animals; D002843:Chromatin / Q000378:metabolism*; D042002:Chromatin Assembly and Disassembly; D000076983:Histone Methyltransferases; D011495:Histone-Lysine N-Methyltransferase / Q000378:metabolism*; D006657:Histones / Q000378:metabolism*; D006801:Humans; D008745:Methylation; D011496:Protein Methyltransferases; D011499:Protein Processing, Post-Translational
D002843:Chromatin; D006657:Histones; D000076983:Histone Methyltransferases; D011496:Protein Methyltransferases; D011495:Histone-Lysine N-Methyltransferase