Age-specific salivary immunoglobulin A response to Streptococcus mutans GbpB.
In a follow-up study of children infected with Streptococcus mutans at an early age (children previously shown to respond poorly to S. mutans GbpB), there was a delay in their immune response, rather than a complete inability to respond to this antigen. Epitopes in the N-terminal third of GbpB were identified as targets for naturally induced immunoglobulin A antibody in children at an early age.
Nogueira
Ruchele D
RD
Department of Oral Diagnosis, Piracicaba School of Dentistry, State University of Campinas, Piracicaba, São Paulo, Brazil.
Alves
Alessandra C
AC
King
William F
WF
Gonçalves
Reginaldo B
RB
Höfling
José F
JF
Smith
Daniel J
DJ
Mattos-Graner
Renata O
RO
D000367:Age Factors; D016022:Case-Control Studies; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D019084:Fluorescent Antibody Technique, Indirect; D005500:Follow-Up Studies; D006801:Humans; D007071:Immunoglobulin A, Secretory / Q000032:analysis* / Q000276:immunology; D008137:Longitudinal Studies; D012463:Saliva / Q000276:immunology*; D013290:Streptococcal Infections / Q000276:immunology*; D013295:Streptococcus mutans / Q000276:immunology*
D007071:Immunoglobulin A, Secretory