The adipose renin-angiotensin system modulates systemic markers of insulin sensitivity and activates the intrarenal renin-angiotensin system.
BACKGROUND
The adipose tissue renin-angiotensin system (RAS) contributes to regulation of fat mass and may also impact systemic functions such as blood pressure and metabolism.


RESULTS
A panel of mouse models including mice lacking angiotensinogen, Agt (Agt-KO), mice expressing Agt solely in adipose tissue (aP2-Agt/Agt-KO), and mice overexpressing Agt in adipose tissue (aP2-Agt) was studied. Total body weight, epididymal fat pad weight, and circulating levels of leptin, insulin, and resistin were significantly decreased in Agt-KO mice, while plasma adiponectin levels were increased. aP2-Agt mice exhibited increased adiposity and plasma leptin and insulin levels compared to wild type (WT) controls. Angiotensinogen and type I Ang II receptor protein levels were also elevated in kidney of aP2-Agt mice.


CONCLUSIONS
These findings demonstrate that alterations in adipose RAS activity significantly impact both local and systemic physiology in a way that may contribute to the detrimental health effects of obesity.
Kim
Suyeon
S
Department of Nutrition and Agricultural Experiment Station, University of Tennessee, Knoxville, TN 37996, USA.
Soltani-Bejnood
Morvarid
M
Quignard-Boulange
Annie
A
Massiera
Florence
F
Teboul
Michele
M
Ailhaud
Gerard
G
Kim
Jung Han
JH
Moustaid-Moussa
Naima
N
Voy
Brynn H
BH