title: Laparoscopic appendectomy in a patient with acute myelogenous leukemia with neutropenia.
abstract: The management of acute myelogenous leukemia is often complicated by infections due to neutropenia, but the appendix is not a common site of infection in adult patients with acute myelogenous leukemia. The diagnosis of acute appendicitis may be delayed or even missed because of the lack of characteristic signs and symptoms associated with acute appendicitis in neutropenic patients. Moreover, urgent surgery may lead to high postoperative complications and mortality rates in these patients. The case presented here is of a 33-year-old Hispanic man with acute myelogenous leukemia who developed severe diffuse acute abdominal pain with positive signs of rebound tenderness, fever, and hypotension ten days after receiving reinduction chemotherapy. The patient was at his nadir, with a white blood cell count of 0.2 x 10(9)/L, platelet count of 20 x 10(9)/L, and hemoglobin of 7 g/dL. A computed tomography scan of the abdomen was suspicious for acute appendicitis. The patient underwent a laparoscopic appendectomy that revealed gangrenous appendicitis. No perioperative complications occurred. The patient was discharged on postoperative day 7 and his chemotherapy was continued as scheduled. Laparoscopic appendectomy may be considered a primary approach in neutropenic patients because it can be associated with less postoperative infection, hemorrhagic complications, and a lower mortality rate.
authors.affiliation: Section of Hematology/Oncology, Department of Medicine, Medical College of Georgia, Augusta, Georgia.
authors.forename: Celalettin
authors.initials: C
authors.lastname: Ustun
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects; D001062:Appendectomy; D001064:Appendicitis / Q000150:complications / Q000601:surgery*; D006801:Humans; D010535:Laparoscopy; D015470:Leukemia, Myeloid, Acute / Q000150:complications* / Q000188:drug therapy; D008297:Male; D009503:Neutropenia / Q000209:etiology
chemical_list: D000970:Antineoplastic Agents