Magnesiation of electron-rich aryl bromides and their use in nickel-catalyzed cross-coupling reactions.
Electron-rich aryl bromides are rapidly converted to the corresponding lithium triarylmagnesiates with (n-Bu)3MgLi, which undergo efficient nickel-catalyzed Kumada-Corriu cross-coupling reactions with a variety of aryl and alkenyl bromides, chlorides, tosylates, and triflates.
Lau
Stephen Y W
SY
Department of Process Research, Merck Frosst Centre for Therapeutic Research, 16711 Trans Canada Highway, Kirkland, QC, Canada H9H 3L1. stephen_lau@merck.com
Hughes
Greg
G
O'Shea
Paul D
PD
Davies
Ian W
IW