title: Dysplastic endocervical curettings: a predictor of cervical squamous cell carcinoma.
abstract: OBJECTIVE
  To identify parameters associated with the presence or development of invasive cervical cancer among patients who underwent cold knife conization (CKC) following loop electrocautery excision procedure (LEEP) revealing positive endocervical curettings for stage 3 cervical intraepithelial neoplasia (CIN III).
  
  
  METHODS
  Patients who underwent CKC following LEEP with endocervical curettings indicating CIN III were observed retrospectively.
  
  
  RESULTS
  Of 146 patients identified, 133 (91.1%) had residual CIN on their cone biopsy; 23 (15.8%) had invasive cervical carcinoma. Patients with residual CIN III, ectocervical and endocervical margins with CIN, and positive endocervical curettings on cone biopsy were more likely to harbor or develop invasive cervical carcinoma.
  
  
  CONCLUSIONS
  Patients with CIN III on endocervical curettage at the time of LEEP procedure are at high risk for harboring residual cervical dysplasia or micros-invasive carcinoma, or developing carcinoma in the future. Residual CIN III, ectocervical or endocervical margins positive for CIN, and/or positive endocervical curettings on CKC subsequent to LEEP with positive endocervical curettings for CIN III all indicate a higher likelihood of harboring or developing cervical carcinoma.
authors.affiliation: Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, State University of New York Downstate Medical Center, Brooklyn, NY 11203, USA. sarah.temkin@gmail.com
authors.forename: Sarah M
authors.initials: SM
authors.lastname: Temkin
authors.forename: Mira
authors.initials: M
authors.lastname: Hellmann
authors.forename: Yi-Chun
authors.initials: YC
authors.lastname: Lee
authors.forename: Ovadia
authors.initials: O
authors.lastname: Abulafia
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy; D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000601:surgery; D002584:Cervix Uteri / Q000473:pathology* / Q000601:surgery; D019092:Conization; D004107:Dilatation and Curettage; D004564:Electrocoagulation; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008875:Middle Aged; D011230:Precancerous Conditions / Q000473:pathology* / Q000601:surgery; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D016896:Treatment Outcome; D002583:Uterine Cervical Neoplasms / Q000473:pathology* / Q000601:surgery; D002578:Uterine Cervical Dysplasia / Q000473:pathology* / Q000601:surgery