Requirement of bic/microRNA-155 for normal immune function.
MicroRNAs are a class of small RNAs that are increasingly being recognized as important regulators of gene expression. Although hundreds of microRNAs are present in the mammalian genome, genetic studies addressing their physiological roles are at an early stage. We have shown that mice deficient for bic/microRNA-155 are immunodeficient and display increased lung airway remodeling. We demonstrate a requirement of bic/microRNA-155 for the function of B and T lymphocytes and dendritic cells. Transcriptome analysis of bic/microRNA-155-deficient CD4+ T cells identified a wide spectrum of microRNA-155-regulated genes, including cytokines, chemokines, and transcription factors. Our work suggests that bic/microRNA-155 plays a key role in the homeostasis and function of the immune system.
Rodriguez
Antony
A
Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
Vigorito
Elena
E
Clare
Simon
S
Warren
Madhuri V
MV
Couttet
Philippe
P
Soond
Dalya R
DR
van Dongen
Stijn
S
Grocock
Russell J
RJ
Das
Partha P
PP
Miska
Eric A
EA
Vetrie
David
D
Okkenhaug
Klaus
K
Enright
Anton J
AJ
Dougan
Gordon
G
Turner
Martin
M
Bradley
Allan
A
D020413:3' Untranslated Regions; D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D016207:Cytokines / Q000096:biosynthesis; D003713:Dendritic Cells / Q000276:immunology*; D005786:Gene Expression Regulation; D018390:Gene Targeting; D006706:Homeostasis; D007107:Immune System / Q000502:physiology*; D007074:Immunoglobulin G / Q000096:biosynthesis; D008168:Lung / Q000473:pathology; D008171:Lung Diseases / Q000276:immunology / Q000473:pathology; D008213:Lymphocyte Activation; D051379:Mice; D035683:MicroRNAs / Q000235:genetics / Q000502:physiology*; D020411:Oligonucleotide Array Sequence Analysis; D051257:Proto-Oncogene Proteins c-maf / Q000235:genetics / Q000502:physiology; D012481:Salmonella Infections, Animal / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D018417:Th1 Cells / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology; D014611:Vaccination
D020413:3' Untranslated Regions; D016207:Cytokines; D007074:Immunoglobulin G; D035683:MicroRNAs; D051257:Proto-Oncogene Proteins c-maf