Palladium-catalyzed conjugate reduction of enones into alpha,beta-dideuterioketones with hexamethyldisilane and deuterium oxide.
Conjugated enones are reduced by readily available Me(3)SiSiMe(3) and D(2)O in the presence of a catalytic amount of [PdCl(eta(3)-C(3)H(5))](2)-PPh(3) to give alpha,beta-dideuterioketones.
Otsuka
Hidehito
H
Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606-8502, Japan.
Shirakawa
Eiji
E
Hayashi
Tamio
T
D002384:Catalysis; D017666:Deuterium Oxide / Q000737:chemistry*; D007553:Isotope Labeling; D007659:Ketones / Q000737:chemistry*; D010084:Oxidation-Reduction; D010165:Palladium / Q000737:chemistry*; D012821:Silanes / Q000737:chemistry*
D007659:Ketones; D012821:Silanes; C520781:hexamethyldisilane; D010165:Palladium; D017666:Deuterium Oxide