[Expression of kinase insert domain-containing receptor in prostate adenocarcinoma].
OBJECTIVE
To investigate the correlation between the expression of the kinase insert domain-containing receptor (KDR) and the histological grade of prostate adenocarcinoma.


METHODS
Forty-eight samples of prostate adenocarcinoma tissues and 20 samples of benign prostatic hypertrophy (BPH) tissues were studied by LsAB immunohistochemical staining.


RESULTS
The positive expression rate of KDR was 73% in prostate adenocarcinoma and 30% in BPH. The expression of KDR was stronger in prostate adenocarcinoma, and there was no relationship between staining intensity and the histological grade of carcinoma.


CONCLUSIONS
KDR, expressed more highly in prostate adenocarcinoma, promises to be a new target in the treatment of prostate adenocarcinoma.
Bai
An-sheng
AS
Department of Urology, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China. ansheng-bai@sohu.com
Zeng
Hao
H
Li
Xiang
X
Wei
Qiang
Q
Li
Hong
H
Yang
Yu-ru
YR
D000230:Adenocarcinoma / Q000378:metabolism*; D006801:Humans; D008297:Male; D011470:Prostatic Hyperplasia / Q000378:metabolism*; D011471:Prostatic Neoplasms / Q000378:metabolism*; D040262:Receptors, Vascular Endothelial Growth Factor / Q000096:biosynthesis*; D040301:Vascular Endothelial Growth Factor Receptor-2 / Q000096:biosynthesis*
D040262:Receptors, Vascular Endothelial Growth Factor; D040301:Vascular Endothelial Growth Factor Receptor-2