title: Support for involvement of the AHI1 locus in schizophrenia.
abstract: Recently, markers in the Abelson Helper Integration Site 1 (AHI1) region were shown to be associated with schizophrenia in a family sample of Israeli-Arabs. Here, we report a study evaluating the relevance of the AHI1 region to schizophrenia in an Icelandic sample. Seven markers shown to confer risk in the previous report were typed in 608 patients diagnosed with broad schizophrenia and 1,504 controls. Odds ratios for the overtransmitted alleles in the Israeli-Arab families ranged from 1.15 to 1.29 in the Icelandic sample. After Bonferroni correction for the seven markers tested, two markers were significantly associated with schizophrenia. Thus, our results are in general agreement with the previous report, with the strongest association signal observed in a region upstream of the AHI1 gene.
authors.affiliation: deCODE genetics, Reykjavik, Iceland.
authors.forename: Andres
authors.initials: A
authors.lastname: Ingason
authors.forename: Thordur
authors.initials: T
authors.lastname: Sigmundsson
authors.forename: Stacy
authors.initials: S
authors.lastname: Steinberg
authors.forename: Engilbert
authors.initials: E
authors.lastname: Sigurdsson
authors.forename: Magnus
authors.initials: M
authors.lastname: Haraldsson
authors.forename: Brynja B
authors.initials: BB
authors.lastname: Magnusdottir
authors.forename: Michael L
authors.initials: ML
authors.lastname: Frigge
authors.forename: Augustine
authors.initials: A
authors.lastname: Kong
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Gulcher
authors.forename: Unnur
authors.initials: U
authors.lastname: Thorsteinsdottir
authors.forename: Kari
authors.initials: K
authors.lastname: Stefansson
authors.forename: Hannes
authors.initials: H
authors.lastname: Petursson
authors.forename: Hreinn
authors.initials: H
authors.lastname: Stefansson
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics*; D033942:Adaptor Proteins, Vesicular Transport; D016022:Case-Control Studies; D005819:Genetic Markers; D006801:Humans; D007055:Iceland; D012559:Schizophrenia / Q000235:genetics*
chemical_list: C487178:AHI1 protein, human; D048868:Adaptor Proteins, Signal Transducing; D033942:Adaptor Proteins, Vesicular Transport; D005819:Genetic Markers