Cumulative skin irritation test of sanitary pads in sensitive skin and normal skin population.
OBJECTIVE
We performed a randomized, paired, double-blind trial involving 14 participants with self-declared normal skin and 15 participants with self-declared sensitive skin to test the cutaneous compatibility of materials of low irritation potential for skin irritation (sanitary pads) elicited by repetitive topical application.


METHODS
Two test products patches and two control substance patches were applied to the lateral aspect of the upper arm once daily under fully occlusive conditions for 4 days. The positive control patch was moistened with sodium lauryl sulphate (0.1% w/v) and the negative control patch was moistened with 0.9% sodium chloride, as were the two test material patches. The patches were removed, skin irritation (erythema) graded, and new patches applied after each 24-hour period.


RESULTS
There was no significant difference in skin irritation from the test patches between the sensitive and normal skin groups. The two test patches and the negative control patch were significantly less irritating than the positive control in both test groups. Both test patches were comparable to the negative control patch in the normal and sensitive skin groups.


CONCLUSIONS
The test materials produced similar degrees of skin irritation among both groups. Overall, there was no statistically significant difference in skin compatibility when the two feminine hygiene product test patches were worn by self-declared normal and sensitive skin groups.
Farage
Miranda A
MA
The Procter & Gamble Company, Cincinnati, Ohio 45224, USA. farage.m@pg.com
Maibach
Howard
H
D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis* / Q000209:etiology; D017453:Dermatitis, Irritant / Q000175:diagnosis* / Q000209:etiology; D004311:Double-Blind Method; D004890:Erythema / Q000139:chemically induced; D005260:Female; D006801:Humans; D008297:Male; D052576:Menstrual Hygiene Products / Q000009:adverse effects*; D008875:Middle Aged; D012720:Severity of Illness Index; D012867:Skin / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology; D023422:Skin Irritancy Tests / Q000379:methods*; D012965:Sodium Chloride / Q000008:administration & dosage; D012967:Sodium Dodecyl Sulfate / Q000008:administration & dosage; D013997:Time Factors
D012967:Sodium Dodecyl Sulfate; D012965:Sodium Chloride