title: [Detection of acid mucins in gastric metaplasia of the gallbladder].
abstract: OBJECTIVE
  In this paper we present a histological and histochemical study about the metaplastic changes in the gallbladder, and discussed the participation of the antral metaplasia in the genesis of gallbladder cancer.
  
  
  METHODS
  We collected 43 pieces of colecistectomy whit antral metaplasia, intestinal metaplasia and displasia. Presence of mucins were demonstrated by the alcian blue stain to ph 3 and ph 0.5 ph.
  
  
  RESULTS
  We found sulphated and not sulphated acid mucins. In all of the forms of antral metaplasia. The not freguent finding coas an intense staining of intracitoplasmie mucins in metaplastic cells. We alsa detected small globular deposits in isolated cells of surface epithelium.
  
  
  CONCLUSIONS
  This finding seems to associate antral metaplasia with intestinal metaplasia, at least in the mucins production. Antral metaplasia could be one of the first steps involved in the sequence displasia-cancer in the gallbladder.
authors.affiliation: Servicio de Patologia, Hospital Interzonal Dr. J. Penna, Bahía Blanca, Argentina. caroabuitrago@hotmail.com
authors.forename: Carolina
authors.initials: C
authors.lastname: Buitrago Salassa
authors.forename: Pablo
authors.initials: P
authors.lastname: Javier Lespi
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005704:Gallbladder / Q000378:metabolism / Q000473:pathology*; D005753:Gastric Mucosa / Q000378:metabolism / Q000473:pathology*; D006651:Histocytochemistry; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008679:Metaplasia / Q000378:metabolism / Q000473:pathology; D008875:Middle Aged; D009077:Mucins / Q000032:analysis* / Q000378:metabolism; D011706:Pyloric Antrum / Q000378:metabolism / Q000473:pathology; D012720:Severity of Illness Index
chemical_list: D009077:Mucins