Preparation of quinoline hexose analogs as novel chloroquine-resistant malaria treatments (1). Synthesis of 4-hydroxyquinoline-beta-glucosides.
Quinoline hexose analogs are expected to be useful as novel agents for treatment of chloroquine-resistant malaria. Here, we report preparation of 4-hydroxy quinoline-beta-glucosides from anilines in 4 steps.
Suzuki
Hiroshi
H
National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-0555, Japan. hiroshis@obihiro.ac.jp
Aly
Nagwa S M
NS
Wataya
Yusuke
Y
Kim
Hye-Sook
HS
Tamai
Ikumi
I
Kita
Masaki
M
Uemura
Daisuke
D
D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D002738:Chloroquine / Q000494:pharmacology*; D004351:Drug Resistance; D005960:Glucosides / Q000138:chemical synthesis* / Q000494:pharmacology*; D006601:Hexoses / Q000138:chemical synthesis* / Q000494:pharmacology*; D006868:Hydrolysis; D006912:Hydroxyquinolines / Q000138:chemical synthesis* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D010963:Plasmodium falciparum / Q000187:drug effects; D015363:Quinolones / Q000138:chemical synthesis* / Q000494:pharmacology*; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared
D000962:Antimalarials; D005960:Glucosides; D006601:Hexoses; D006912:Hydroxyquinolines; D015363:Quinolones; D002738:Chloroquine