Characterization of the chemical components on the surface of different solids with electrospray-assisted laser desorption ionization mass spectrometry.
In this study we demonstrate that electrospray-assisted laser desorption ionization (ELDI) mass spectrometry (MS) can be used to rapidly characterize major chemical components on the surfaces of different solids under ambient conditions. The major chemical components in (a) dried milks with different fat contents, (b) different color-regions of a painting, (c) the thin coating on a compact disc, (d) drug tablets, and (e) porcine brain tissue were rapidly characterized as protonated molecules [M+H](+) or sodiated molecules [M+Na](+) by ELDI-MS with minimum sample pretreatment. The ionized ions of synthetic polymer and dye standards were detected directly from dried sample solutions using either positive or negative ion mode. Further structural information for the FD&C Red dye was obtained through tandem mass spectrometric (MS/MS) analysis using an ion trap mass analyzer attached to the ELDI source.
Huang
Min-Zong
MZ
Department of Chemistry, National Sun Yat-Sen University, Kaohsiung, Taiwan.
Hsu
Hsiu-Jung
HJ
Wu
Chen-I
CI
Lin
Shu-Yao
SY
Ma
Ya-Lin
YL
Cheng
Tian-Lu
TL
Shiea
Jentaie
J
D000818:Animals; D001154:Art; D001923:Brain Chemistry; D003116:Color; D004396:Coloring Agents / Q000737:chemistry; D016250:Compact Disks; D008055:Lipids / Q000032:analysis; D008892:Milk / Q000737:chemistry; D004364:Pharmaceutical Preparations / Q000032:analysis; D011108:Polymers / Q000737:chemistry; D012015:Reference Standards; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Q000379:methods*; D013499:Surface Properties; D013552:Swine
D004396:Coloring Agents; D008055:Lipids; D004364:Pharmaceutical Preparations; D011108:Polymers