Immunoscintigraphy of local recurrent rectal cancer with 99mTc-labeled anti-CEA monoclonal antibody CL58.
OBJECTIVE
To explore a specific diagnostic method for local recurrent rectal cancer.


METHODS
Immunoscintigraphy with (99m)Tc-labeled anti-CEA monoclonal antibody (MoAb) CL-58 was performed for patients suspected of having a postoperative local recurrent rectal cancer and the findings were compared with the results of conventional imaging and pathology.


RESULTS
A total of 36 patients with a suspected local recurrent rectal cancer underwent immunoscintigraphy with (99m)Tc-conjugated CL58. Local recurrence of rectal cancer was identified in 31 patients and established in 30 during operation, endoscopy and pathological examination. No local recurrence was found in 5 patients without specific accumulation of (99m)Tc during the follow-up. Immunoscintigraphy had a positive rate of 86.11%, a specificity of 83.33%, and a sensitivity of 100%.


CONCLUSIONS
Immunoscintigraphy has a highly specific and predictive value for detecting local recurrent rectal cancer, especially after abdominal perineal resection (APR).
Yao
Yun-Feng
YF
Peking University School of Oncology, Beijing 100036, China.
Yang
Zhi
Z
Li
Zhen-Fu
ZF
Gu
Jin
J
D000911:Antibodies, Monoclonal / Q000276:immunology; D002272:Carcinoembryonic Antigen / Q000097:blood / Q000276:immunology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging* / Q000276:immunology; D049268:Positron-Emission Tomography; D011237:Predictive Value of Tests; D016719:Radioimmunodetection / Q000379:methods*; D012004:Rectal Neoplasms / Q000000981:diagnostic imaging* / Q000276:immunology / Q000473:pathology; D012680:Sensitivity and Specificity; D013667:Technetium; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography
D000911:Antibodies, Monoclonal; D002272:Carcinoembryonic Antigen; D013667:Technetium