title: Serum antibodies to the pneumococcal surface proteins PhtB and PhtE in Finnish infants and adults.
abstract: We examined naturally acquired antibodies to pneumococcal vaccine candidate proteins PhtB and PhtE in children during their first 2 years of life. Prior culture-confirmed pneumococcal exposure was shown to induce the development of anti-PhtB and -PhtE antibodies. The anti-PhtB or -PhtE antibody concentrations were not significantly associated with a decreased risk of subsequent pneumococcal acute otitis media.
authors.affiliation: The National Public Health Institute, Helsinki, Finland.
authors.forename: Emma
authors.initials: E
authors.lastname: Holmlund
authors.forename: Birgit
authors.initials: B
authors.lastname: Simell
authors.forename: Teija
authors.initials: T
authors.lastname: Jaakkola
authors.forename: Mika
authors.initials: M
authors.lastname: Lahdenkari
authors.forename: Josée
authors.initials: J
authors.lastname: Hamel
authors.forename: Bernard
authors.initials: B
authors.lastname: Brodeur
authors.forename: Terhi
authors.initials: T
authors.lastname: Kilpi
authors.forename: Helena
authors.initials: H
authors.lastname: Käyhty
mesh_terms: D000208:Acute Disease; D000328:Adult; D000367:Age Factors; D000907:Antibodies, Bacterial / Q000097:blood*; D001426:Bacterial Proteins / Q000276:immunology*; D006801:Humans; D006867:Hydrolases / Q000276:immunology*; D007223:Infant; D008565:Membrane Proteins / Q000276:immunology; D010033:Otitis Media / Q000209:etiology; D013296:Streptococcus pneumoniae / Q000276:immunology*
chemical_list: D000907:Antibodies, Bacterial; D001426:Bacterial Proteins; D008565:Membrane Proteins; C097552:histidine triad protein; D006867:Hydrolases