Adiponectin incompletely prevent MCP-1-dependent restenosis after percutaneous coronary intervention [corrected] in patients with coronary artery disease.
BACKGROUND
Some factors play pathogenic roles in the development of restenosis after percutaneous coronary intervention (PCI). We measured and compared the ratio of elevated levels of monocytic chemotactic peptide-1 (MCP-1), regulated on activation normally T-cell expressed and secreted (RANTES), soluble (s) P-selectin, sE-selectin and adiponectin after PCI.


METHODS
Plasma levels of chemokines and soluble markers were measured before and 30 days after PCI in 96 patients (69 males and 27 females, aged 63 +/- 9 years) who underwent PCI and who had repeated angiograms at a 6-month follow-up. In addition, we carried out the basic study of the tissue factor expression on monocytic cell line (THP-1) by MCP-1.


RESULTS
Restenosis occurred in 33 (34.4%) patients. A significant and time-dependent increase in MCP-1 was observed in the restenosis group. However, there were no significant differences in RANTES, sP-selectin, and sE-selectin levels with or without restenosis. Adiponectin levels in patients with coronary artery disease were significantly lower than levels in normal controls. However, adiponectin levels were no different at baseline between patients with or without restenosis. MCP-1 did not induce the expression of tissue factor on THP-1. However, the recombinant sCD40 ligand-induced expression of tissue factor on THP-1 was enhanced by the addition of MCP-1.


CONCLUSIONS
These findings suggest that restenosis development after PCI in patients with coronary artery disease may involve the participation of MCP-1 after PCI, and adiponectin incompletely prevent this MCP-1-dependent restenosis.
Inami
Norihito
N
Second Department of Internal Medicine, Kansai Medical University, Moriguchi, Osaka, Japan.
Nomura
Shosaku
S
Shimazu
Takayuki
T
Manabe
Kenichi
K
Kimura
Yutaka
Y
Iwasaka
Toshiji
T
D052242:Adiponectin / Q000097:blood; D000328:Adult; D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D016022:Case-Control Studies; D002460:Cell Line; D018932:Chemokine CCL2 / Q000097:blood*; D018946:Chemokine CCL5 / Q000097:blood; D003324:Coronary Artery Disease / Q000601:surgery; D023903:Coronary Restenosis / Q000097:blood / Q000503:physiopathology*; D019040:E-Selectin; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000378:metabolism*; D019007:P-Selectin / Q000097:blood
C499918:ADIPOQ protein, human; D052242:Adiponectin; D018932:Chemokine CCL2; D018946:Chemokine CCL5; D019040:E-Selectin; D019007:P-Selectin