Nitric oxide release from coumarin-7-azomethine derivatives in the presence of thiol.
A series of coumarin derivatives containing a 7-azomethine linkage with anti-inflammatory activity were tested for nitric oxide release in the presence of thiol cofactors in vitro. It was found that nitric oxide release was dependent on the nature of thiol.
Kontogiorgis
Christos A
CA
Department of Pharmaceutical Chemistry, School of Pharmacy, Aristotle University of Thessaloniki, Greece.
Hadjipavlou-Litina
Dimitra
D
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000737:chemistry; D000975:Antioxidants / Q000138:chemical synthesis* / Q000737:chemistry; D001391:Azo Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D003374:Coumarins / Q000138:chemical synthesis* / Q000494:pharmacology*; D003545:Cysteine / Q000378:metabolism; D004121:Dimethyl Sulfoxide / Q000378:metabolism; D009569:Nitric Oxide / Q000737:chemistry*; D020030:Nitric Oxide Donors / Q000138:chemical synthesis* / Q000737:chemistry*; D009573:Nitrites / Q000378:metabolism; D013438:Sulfhydryl Compounds / Q000737:chemistry*; D013882:Thiosemicarbazones / Q000138:chemical synthesis* / Q000494:pharmacology*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000975:Antioxidants; D001391:Azo Compounds; D003374:Coumarins; D020030:Nitric Oxide Donors; D009573:Nitrites; D013438:Sulfhydryl Compounds; D013882:Thiosemicarbazones; C512188:azomethine; D009569:Nitric Oxide; C030123:coumarin; D003545:Cysteine; D004121:Dimethyl Sulfoxide