title: Treatment of feline hypertension with transdermal amlodipine: a pilot study.
abstract: This prospective study evaluated transdermal amlodipine for the control of hypertension in six cats. Cats were treated with oral amlodipine until blood pressures decreased to <180 mm Hg. They were maintained on this dose for 7 days and then administered identical doses of transdermal amlodipine for 7 days. Oral amlodipine decreased pressure by a median of 73 mm Hg, which subsequently increased by 20 mm Hg after 7 days of transdermal amlodipine. Plasma concentrations of amlodipine were measured after oral and transdermal dosing. Additional studies are needed to determine dosing, pharmacokinetics, and efficacy.
authors.affiliation: Unifour Veterinary Referrals, Hickory, North Carolina 28602, USA.
authors.forename: Scott Roderick
authors.initials: SR
authors.lastname: Helms
mesh_terms: D000279:Administration, Cutaneous; D000284:Administration, Oral; D017311:Amlodipine / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics; D000818:Animals; D000959:Antihypertensive Agents / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics; D001682:Biological Availability; D001794:Blood Pressure / Q000187:drug effects; D002371:Cat Diseases / Q000188:drug therapy*; D002415:Cats; D005260:Female; D006973:Hypertension / Q000188:drug therapy / Q000662:veterinary*; D008297:Male; D008954:Models, Biological; D010865:Pilot Projects; D011446:Prospective Studies
chemical_list: D000959:Antihypertensive Agents; D017311:Amlodipine