[Molecular bases of heart failure].
Heart failure (HF) is a complex pathophysiologic state in which delivery of blood and nutrients is inadequate for tissue requirements. HF almost always arises in patients with previous cardiovascular disease such as acute myocardial infarction, atherosclerosis, cardiomyopathy, myocarditis, congenital malformations, or valvular disease. Recently, substantial progress has been made to understand the etiology, pathogenesis, and mechanisms of HF. Several inter-related mechanisms such as oxidative stress, signal transduction, abnormalities in intracellular calcium handling, mitochondrial dysfunction and inherited mutations have been proposed as the triggers of HF.
Rodríguez Pérez
José Manuel
JM
Departamento de Fisiologia y Grupo de Estudio en Genómica y Proteómica en Enfermedades Cardiovasculares, Instituto Nacional de Cardiología "Ignacio Chávez".
Gallardo
Guillermo J
GJ
Vargas Alarcón
Gilberto
G
D017209:Apoptosis; D002118:Calcium / Q000378:metabolism; D002311:Cardiomyopathy, Dilated / Q000235:genetics; D002312:Cardiomyopathy, Hypertrophic / Q000235:genetics; D016757:Death, Sudden, Cardiac / Q000209:etiology; D006333:Heart Failure / Q000209:etiology* / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000150:complications; D008929:Mitochondria, Heart; D028361:Mitochondrial Diseases / Q000150:complications; D009154:Mutation; D009203:Myocardial Infarction / Q000150:complications; D018384:Oxidative Stress; D015398:Signal Transduction
D002118:Calcium