title: CD109, a new marker for myoepithelial cells of mammary, salivary, and lacrimal glands and prostate basal cells.
abstract: The CD109 gene encodes a glycosylphosphatidylinositol (GPI)-anchored cell surface protein. Herein it is shown that CD109 is highly expressed in myoepithelial cells of mammary, salivary, and lacrimal glands; and in prostate basal cells. The anti-CD109 antibody generated by the authors was available for formalin-fixed paraffin section, and it strongly stained myoepithelial cells and basal cells but not ductal, acinar, and secretory cells in these glands. CD109 expression was negative in examined breast ductal carcinomas and prostate adenocarcinomas. These findings indicate that CD109 is a useful marker for the diagnosis of invasive breast and prostate carcinomas.
authors.affiliation: Department of Pathology, Nagoya University Graduate School of Medicine, and Department of Pathology, National Hospital Organization, Nagoya Medical Center, Nagoya, Japan.
authors.forename: Masaki
authors.initials: M
authors.lastname: Hasegawa
authors.forename: Sumitaka
authors.initials: S
authors.lastname: Hagiwara
authors.forename: Tomoko
authors.initials: T
authors.lastname: Sato
authors.forename: Mayumi
authors.initials: M
authors.lastname: Jijiwa
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Murakumo
authors.forename: Masahiro
authors.initials: M
authors.lastname: Maeda
authors.forename: Suzuko
authors.initials: S
authors.lastname: Moritani
authors.forename: Shu
authors.initials: S
authors.lastname: Ichihara
authors.forename: Masahide
authors.initials: M
authors.lastname: Takahashi
mesh_terms: D015703:Antigens, CD / Q000032:analysis* / Q000235:genetics; D015415:Biomarkers / Q000032:analysis*; D015153:Blotting, Western; D001943:Breast Neoplasms / Q000378:metabolism / Q000473:pathology; D002460:Cell Line; D045744:Cell Line, Tumor; D005260:Female; D058851:GPI-Linked Proteins; D006801:Humans; D007150:Immunohistochemistry; D007765:Lacrimal Apparatus / Q000737:chemistry / Q000166:cytology; D008297:Male; D042361:Mammary Glands, Human / Q000737:chemistry / Q000166:cytology; D009363:Neoplasm Proteins / Q000032:analysis* / Q000235:genetics; D011467:Prostate / Q000737:chemistry / Q000166:cytology; D011471:Prostatic Neoplasms / Q000378:metabolism / Q000473:pathology; D034622:RNA Interference; D012468:Salivary Gland Neoplasms / Q000378:metabolism / Q000473:pathology; D012469:Salivary Glands / Q000737:chemistry / Q000166:cytology; D014162:Transfection
chemical_list: D015703:Antigens, CD; D015415:Biomarkers; C120523:CD109 protein, human; D058851:GPI-Linked Proteins; D009363:Neoplasm Proteins