title: Gait patterns of a patient with myoclonus of a lower limb, when OFF and ON treatment with antiepileptic drugs.
abstract: We describe kinematics, kinetics and electromyographic patterns of a patient with spinal myoclonus of the left lower limb, during walking. Gait analysis was performed when the patient was OFF and ON his treatment with antiepileptic drugs. When OFF, we mainly observed clonic bursts and out-of-phase activations of m. tibialis anterior and m. rectus femoris, with increased hip flexion, reduction of knee flexion during swing and excessive ankle dorsal flexion. Furthermore, large oscillations of knee moment of force and power during stance phase were also observed. These abnormal patterns markedly recovered when ON drugs.
authors.affiliation: Department of Experimental and Clinical Pharmacology, Medical School, University of Catania, V.le A. Doria 6, I-95125 Catania, Italy. mcioni@unict.it
authors.forename: M
authors.initials: M
authors.lastname: Cioni
authors.forename: I
authors.initials: I
authors.lastname: Iero
authors.forename: G
authors.initials: G
authors.lastname: Tornatore
authors.forename: A
authors.initials: A
authors.lastname: Cocilovo
authors.forename: A
authors.initials: A
authors.lastname: Belfiore
authors.forename: R
authors.initials: R
authors.lastname: Ferri
mesh_terms: D000927:Anticonvulsants / Q000494:pharmacology* / Q000627:therapeutic use; D001683:Biological Clocks / Q000187:drug effects / Q000502:physiology; D001696:Biomechanical Phenomena / Q000379:methods; D020233:Gait Disorders, Neurologic / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology*; D006801:Humans; D007717:Knee / Q000503:physiopathology; D007866:Leg / Q000294:innervation / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009119:Muscle Contraction / Q000187:drug effects / Q000502:physiology; D018482:Muscle, Skeletal / Q000294:innervation / Q000503:physiopathology*; D009207:Myoclonus / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology*; D009460:Neurologic Examination / Q000379:methods; D011237:Predictive Value of Tests; D052097:Quadriceps Muscle / Q000294:innervation / Q000503:physiopathology; D013116:Spinal Cord / Q000187:drug effects / Q000503:physiopathology; D013118:Spinal Cord Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology*
chemical_list: D000927:Anticonvulsants