Attentional processing in adults with ADHD as reflected by event-related potentials.
Attention deficit/hyperactivity disorder (ADHD) is a well known childhood disease and well researched via event-related potentials (ERPs), but unfortunately there is little information on this illness in adults in ERPs. In the present study, 12 adults diagnosed with ADHD and 12 healthy control adults were examined with respect to ERPs in a visual Go/NoGo-experiment to gain information about target evaluation processing in these patients. Two attention-related ERP-components, the N1 and N2 were significantly increased for the ADHD adults compared to the healthy control adults. These findings were illustrated using source analysis results: In the time frame corresponding to the N1, significant increases of activity were found in the medial frontal gyrus and during the N2 time frame significant increases were detected in the lingual gyrus. The P300 showed a tendency towards decreased activity in the patient group, however, only a subsequent slow wave activity indicated significant differences. Neuronal activity related to early attentional mechanisms (N1 and N2) appears to be enhanced in ADHD patients. Together with the finding of a reduction in the P300, the data suggest that ADHD adults have learned to gather their attention more strongly than healthy adults in order to achieve the same results and compensate for their impairment. This is supported by the source analysis results which show activity in additional brain areas.
Prox
Vanessa
V
Department of Clinical Psychiatry and Psychotherapy, Medical University of Hannover (MHH), Carl-Neuberg-Strasse 1, D-30625 Hannover, Germany.
Dietrich
Detlef E
DE
Zhang
Yuanyuan
Y
Emrich
Hinderk M
HM
Ohlmeier
Martin D
MD
D000222:Adaptation, Physiological / Q000502:physiology*; D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D001288:Attention / Q000502:physiology*; D001289:Attention Deficit Disorder with Hyperactivity / Q000503:physiopathology*; D001931:Brain Mapping; D005071:Evoked Potentials / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged