title: Supplemental oxygen effects on ventilation in acclimatized subjects exercising at 5700 m altitude.
abstract: BACKGROUND
  This study examines the effect of supplemental oxygen on acclimatized mountaineers at high altitude during rest and submaximal exercise.
  
  
  METHODS
  Three healthy, acclimatized participants undertook nine periods of data collection lasting 10 min each over 2 consecutive days at 5700 m. These occurred at rest and exercise (40 and 80 W), breathing ambient air or supplemental oxygen (2 and 4 L m min') through an open-circuit breathing system.
  
  
  RESULTS
  As minute ventilation increased during exercise, the fraction of inspired oxygen (FIO2) fell from 0.31 at rest to 0.23 with 2 L x min(-1) of oxygen and from 0.36 to 0.26 with 4 L x min(-1). Oxygen at both flow rates resulted in a significant increase in the arterial blood saturation of oxygen (SaO2) (Rest: 79% to 96% to 97%; 40 W: 80% to 95% to 97%; 80 W: 76% to 94% to 98%) and reduction in respiratory rate (RR) (Rest: 28 to 22 to 24; 40 W: 36 to 25 to 25; 80 W: 41 to 26 to 26). Tidal volume (VT, ml x s(-1)) was found to increase with the addition of oxygen (Rest: 959 to 844 to 969; 40 W: 1393 to 1834 to 1851; 80 W: 1558 to 2105 to 2215) and resulted in a non-significant reduction in minute ventilation (VE, L) (Rest: 25 to 17 to 21; 40 W: 46 to 45 to 43; 80 W: 61 to 51 to 53). No significant changes in heart rate were observed when oxygen was used (Rest: 78 to 62 to 71; 40 W: 90 to 91 to 96; 80 W: 105 to 102 to 101).
  
  
  CONCLUSIONS
  An open-circuit breathing system may increase SaO2 and reduce RR in acclimatized mountaineers during rest and sub-maximal exercise at 5700 m, though further research is needed to confirm this.
authors.affiliation: Centre for Aviation, Space and Extreme Environment Medicine, University College London, London, UK. jswindsor@doctors.org.uk
authors.forename: Jeremy S
authors.initials: JS
authors.lastname: Windsor
authors.forename: George W
authors.initials: GW
authors.lastname: Rodway
mesh_terms: D000064:Acclimatization; D000222:Adaptation, Physiological; D000328:Adult; D000531:Altitude; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test; D006801:Humans; D006931:Hyperbaric Oxygenation; D008297:Male; D009051:Mountaineering / Q000502:physiology*; D010865:Pilot Projects