Hypoglycemia during sleep impairs consolidation of declarative memory in type 1 diabetic and healthy humans.
OBJECTIVE
Early nocturnal sleep enhances the consolidation of declarative memories acquired during prior wakefulness. Patients with type 1 diabetes frequently experience hypoglycemic episodes during sleep. We investigated whether short-lasting hypoglycemia during early nocturnal sleep affects the sleep-associated consolidation of declarative memories.


METHODS
Sixteen type 1 diabetic patients and 16 healthy subjects matched for age and BMI were tested. On one condition, a linear fall of plasma glucose to 2.2 mmol/l was induced within 60 min by infusing insulin during early sleep. On the control condition, euglycemia (>3.86 mmol/l) was maintained throughout the night. In the morning, subjects recalled word pairs learned in the preceding evening. To assess mood and attention, a symptom questionnaire, an adjective check list, and the Stroop test were applied. Also, auditory event-related brain potentials were recorded.


RESULTS
After euglycemia, subjects recalled 1.5 +/- 0.5 more word pairs than after hypoglycemia (P < 0.01), remembering 2.0 +/- 0.6 more word pairs than at immediate recall before sleep (P = 0.002). Across the hypoglycemic night, no such gain occurred (+0.5 +/- 0.6 words; P = 0.41). Hypoglycemia during sleep also impaired mood (P < 0.05) but did not affect attention. Effects compared well between type 1 diabetic patients and healthy control subjects.


CONCLUSIONS
Our findings indicate specific sensitivity of declarative memory consolidation during sleep to rather short episodes of mild hypoglycemia. This effect may disable memory processing in type 1 diabetic patients prone to nocturnal hypoglycemic episodes and underlines the importance of considering sleep as a critical period in the treatment of these patients.
Jauch-Chara
Kamila
K
Internal Medicine I, University of Luebeck, Luebeck, Germany.
Hallschmid
Manfred
M
Gais
Steffen
S
Schmid
Sebastian M
SM
Oltmanns
Kerstin M
KM
Colmorgen
Caterina
C
Born
Jan
J
Schultes
Bernd
B
D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000523:psychology*; D005071:Evoked Potentials; D006801:Humans; D007003:Hypoglycemia / Q000523:psychology*; D008568:Memory; D008569:Memory Disorders / Q000453:epidemiology / Q000209:etiology*; D012016:Reference Values; D012890:Sleep / Q000502:physiology*; D012894:Sleep Stages; D014851:Wakefulness