title: Inhibitory effects of soy isoflavones on cardiovascular collagen accumulation in rats.
abstract: Oxidative stress is a major cause of cardiovascular tissue fibrosis. We evaluated the effects of daily doses of soy isoflavones, genistein and daidzein on cardiovascular tissue fibrosis in Otsuka Long-Evans Tokushima Fatty (OLETF) diabetic rats and Long-Evans Tokushima Otsuka (LETO) non-diabetic rats as a severe or mild oxidative stress model, respectively. Glucose and lipid metabolisms did not improve with genistein or daidzein treatment. However, genistein decreased hydroxyproline concentrations in the heart. Hydroxyproline reductions as a result of genistein were mildly stronger than those of daidzein. Thus, genistein significantly suppressed the progression of myocardial fibrosis in LETO rats despite the insignificant changes in OLETF rats. Although a daily dosage of isoflavone was not sufficient to prevent tissue fibrosis under marked oxidative stress in the early stage of diabetes, isoflavones might promise significant clinical benefits by reducing oxidative stress in the heart during aging.
authors.affiliation: Department of Applied Bioscience, Faculty of Agriculture, Ehime University, Matsuyama 790-8566, Japan. takamz@kais.kyoto-u.ac.jp
authors.forename: Takafumi
authors.initials: T
authors.lastname: Mizushige
authors.forename: Katsufumi
authors.initials: K
authors.lastname: Mizushige
authors.forename: Akira
authors.initials: A
authors.lastname: Miyatake
authors.forename: Taro
authors.initials: T
authors.lastname: Kishida
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Ebihara
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects; D002319:Cardiovascular System / Q000187:drug effects* / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D003094:Collagen / Q000187:drug effects* / Q000378:metabolism*; D004195:Disease Models, Animal; D018450:Disease Progression; D005355:Fibrosis; D006339:Heart Rate / Q000187:drug effects; D006909:Hydroxyproline / Q000187:drug effects / Q000378:metabolism; D007529:Isoflavones / Q000008:administration & dosage*; D050356:Lipid Metabolism / Q000187:drug effects; D008297:Male; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D009929:Organ Size / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects; D048789:Phytoestrogens / Q000008:administration & dosage*; D051381:Rats; D020334:Rats, Inbred OLETF; D020318:Rats, Long-Evans; D012720:Severity of Illness Index; D045730:Soy Foods
chemical_list: D001786:Blood Glucose; D007529:Isoflavones; D048789:Phytoestrogens; D003094:Collagen; D006909:Hydroxyproline