title: [Flavonoids and the cardiovascular system: can they be a therapeutic alternative?].
abstract: It has been suggested that dietary intake of flavonoids may reduce the risk of cardiovascular diseases. On the other hand, in vitro and in vivo studies shows that flavonoids has a vast array of biological activities. Our aim in this review is to put in evidence the effect of flavonoids on several enzymatic systems that could act as potential therapeutic targets, based on the reports of diverse research groups, leaders in the natural products research area, have published through the years, and with the goal of consolidating those results with the findings provided by some epidemiological studies, could support the introduction of these compounds into the clinic.
authors.affiliation: Departamento de Farmacología, Instituto Nacional de Cardiología "Ignacio Chavez", México, D.F. fatl@att.net.mx
authors.forename: Fermín Alejandro
authors.initials: FA
authors.lastname: Tenorio López
authors.forename: Leonardo
authors.initials: L
authors.lastname: del Valle Mondragón
authors.forename: Gustavo
authors.initials: G
authors.lastname: Pastelín Hernández
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000401:mortality / Q000517:prevention & control*; D002986:Clinical Trials as Topic; D004798:Enzymes / Q000187:drug effects; D005419:Flavonoids / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D008875:Middle Aged; D008517:Phytotherapy; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D011794:Quercetin / Q000008:administration & dosage / Q000627:therapeutic use; D012106:Research; D013997:Time Factors
chemical_list: D000975:Antioxidants; D004798:Enzymes; D005419:Flavonoids; D010975:Platelet Aggregation Inhibitors; D011794:Quercetin