Marked improvement of Churg-Strauss vasculitis with intravenous gamma globulins during pregnancy.
Churg-Strauss syndrome (CSS) is an extremely rare disease, and even less common in women of childbearing age. Patients with severe disease or those who are un-responsive to corticosteroids are usually treated with cytotoxic drugs, especially cyclophosphmide. Intravenous immunoglobulin (IVIg) has became a promising, but not completely accepted, form of treatment for systemic vasculitis that is un-responsive to standard therapy. We report a case of a woman who presented with a CSS flare during pregnancy. Because of mono-neuritis, treatment with IVIg was instituted with successful results. Our case not only supports the beneficial effect of IVIg in CSS, but it also illustrates its successful and safe use in a patient who was pregnant. We discuss the indication of IVIg during the course of anti-neutrophil cytoplasm antigen (ANCA) vasculitis during the pregnancy.
Hot
Arnaud
A
Service de Medecine Interne, Hôpital Edouard Herriot, 3 Place Arsonval, Lyon, CEDEX 03, 69003, France. arnaud.hot@wanadoo.fr.
Perard
Laurent
L
Service de Medecine Interne, Hôpital Edouard Herriot, 3 Place Arsonval, Lyon, CEDEX 03, 69003, France.
Coppere
Brigitte
B
Service de Medecine Interne, Hôpital Edouard Herriot, 3 Place Arsonval, Lyon, CEDEX 03, 69003, France.
Simon
Marie
M
Service de Medecine Interne, Hôpital Edouard Herriot, 3 Place Arsonval, Lyon, CEDEX 03, 69003, France.
Bouhour
Françoise
F
Service de Neurologie, Hôpital Pierre Wertheimer, 59, Boulevard Pinel, Bron, 69394, France.
Ninet
Jacques
J
Service de Medecine Interne, Hôpital Edouard Herriot, 3 Place Arsonval, Lyon, CEDEX 03, 69003, France.
D000328:Adult; D015267:Churg-Strauss Syndrome / Q000188:drug therapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D007155:Immunologic Factors / Q000627:therapeutic use*; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000188:drug therapy*; D011256:Pregnancy Outcome
D016756:Immunoglobulins, Intravenous; D007155:Immunologic Factors