Maternal derivative chromosome 9 and recurrent pregnancy loss.
OBJECTIVE
To disclose the relationship between a derivative chromosome 9 and recurrent pregnancy loss.


METHODS
Case report.


METHODS
Referral from primary clinical care to tertiary hospital for further intervention.


METHODS
A 31-year-old woman who had four recurrent early spontaneous abortions.


METHODS
Cytogenetic and fluorescence in situ hybridization analyses of the chromosome harvested from peripheral blood sample.


METHODS
Karyotype of the patient.


RESULTS
The patient has a unique derivative chromosome 9, der(9)(9qter-->9p24::9p24-->9p11::9p13-->9qter). ish der(9) (CEP9x1,43N6x1,D9Z3x1).


CONCLUSIONS
Maternal derivative chromosome 9 may cause recurrent pregnancy loss.
Chang
Ling-Wei
LW
Department of Obstetrics and Gynecology, National Cheng Kung University, College of Medicine, Tainan, Taiwan. lckuan@kgh.com.tw
Lee
I-Wen
IW
Kuo
Pao-Lin
PL
Kuan
Long-Ching
LC
D000026:Abortion, Habitual / Q000235:genetics*; D000328:Adult; D002869:Chromosome Aberrations; D002899:Chromosomes, Human, Pair 9; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D011247:Pregnancy