Atrial natriuretic peptide increases urinary albumin excretion in people with normoalbuminuric type-2 diabetes.
BACKGROUND
Atrial natriuretic peptide (ANP) is elevated in patients with type-2 diabetes and microalbuminuria. The purpose of this study is to evaluate if ANP increases Urinary Albumin Eaxcretion Rate (UAER) in type-2 diabetes.


METHODS
Eight normoalbuminuric diabetic subjects underwent a randomised single blind study of 60 min intravenous infusion of ANP or vehicle. Eight non-diabetic controls underwent ANP infusion alone. Seven normoalbuminuric type-2 diabetes subjects received further ANP infusions during euglycaemia and during hyperglycaemia.


RESULTS
ANP increased urinary sodium (191.3 +/- 80.7 to 529.2 +/- 263.4 mumol/min, mean +/- SD, and P < 0.001) and UAER (72.2 +/- 73.4 to 224.9 +/- 182.9.5 mug/min, and P < 0.01) in diabetic subjects. In controls, UAER did not change significantly (P = 0.16); however, the natriuretic response to ANP was similar to diabetic subjects (P = 0.98). Hyperglycaemic did not enhance the albuminuric response to ANP (P = 0.88).


CONCLUSIONS
ANP increases UAER in normoalbuminuric type-2 diabetic subjects.
Moore
K B
KB
Department of Diabetes and Endocrinology, Diabetes Day Centre, Beaumont Hospital, Dublin 9, Ireland.
McKenna
K
K
Osman
M
M
Tormey
W P
WP
McDonald
D
D
Thompson
C J
CJ
D000328:Adult; D000419:Albuminuria / Q000503:physiopathology*; D009320:Atrial Natriuretic Factor / Q000008:administration & dosage / Q000097:blood / Q000502:physiology*; D006152:Cyclic GMP / Q000652:urine; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology* / Q000652:urine*; D005260:Female; D006801:Humans; D006943:Hyperglycemia / Q000503:physiopathology; D007262:Infusions, Intravenous; D007668:Kidney / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D016037:Single-Blind Method; D012964:Sodium / Q000652:urine
D009320:Atrial Natriuretic Factor; D012964:Sodium; D006152:Cyclic GMP