title: Normal levels of serum IGF-I: determinants and validity of current reference ranges.
abstract: Insulin like growth factor I (IGF-I) represents the key marker for the evaluation of Growth hormone (GH) status. As a large number of determinants including age, gender, genetic factors, nutrition, and disease states influence IGF-I serum levels, accurate normative data are essential to translate patient data into diagnostic meaning or even use IGF-I levels for adequate monitoring of patients with an over- or under-active GH axis. Even though reference ranges have been developed in large cohorts of healthy subjects, the dependency of these data on a given assay technology argues for assay specific normative data for IGF-I.
authors.affiliation: Department of Endocrinology, Christie Hospital, Wilmslow Rd, Manchester M20 4BX, UK. georg.Brabant@Manchester.ac.uk
authors.forename: G
authors.initials: G
authors.lastname: Brabant
authors.forename: H
authors.initials: H
authors.lastname: Wallaschofski
mesh_terms: D004198:Disease Susceptibility; D005260:Female; D019382:Human Growth Hormone / Q000502:physiology; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000032:analysis* / Q000235:genetics / Q000502:physiology / Q000592:standards*; D008297:Male; D012016:Reference Values; D015203:Reproducibility of Results
chemical_list: D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I