HPLC-SPE-NMR characterization of sesquiterpenes in an antimycobacterial fraction from Warburgia salutaris.
HPLC-SPE-NMR analysis of a chemically complex antimycobacterial fraction of Warburgia salutaris allowed the rapid identification of seven new and four known drimane- and coloratane-type sesquiterpenes. This recently introduced hyphenated technique is therefore a highly valuable tool for elucidation of the chemistry of biologically active fractions of natural origin.
Clarkson
Cailean
C
Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Copenhagen, Denmark.
Madikane
Eliya V
EV
Hansen
Steen Honoré
SH
Smith
Peter J
PJ
Jaroszewski
Jerzy W
JW
D000995:Antitubercular Agents / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D019684:Magnoliopsida; D009161:Mycobacterium; D008517:Phytotherapy; D024301:Plant Bark; D010936:Plant Extracts / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry; D052616:Solid Phase Extraction; D013329:Structure-Activity Relationship
D000995:Antitubercular Agents; D010936:Plant Extracts; D012717:Sesquiterpenes