title: Idiopathic hypereosinophilic syndrome with skull base involvement.
abstract: Idiopathic hypereosinophilic syndrome (HES) is a heterogeneous disorder characterized by prolonged eosinophilia without an identifiable cause, ultimately resulting in organ dysfunction. Three major types of neurologic involvement have been well defined in HES; however, to our knowledge, inflammatory pseudotumor (IPT) in association with HES has not been reported. We present a case of IPT of the skull base in a patient with HES that suggests that HES may result in an exaggerated immunologic or inflammatory response leading to the formation of IPT.
authors.affiliation: Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
authors.forename: M L
authors.initials: ML
authors.lastname: Battineni
authors.forename: S L
authors.initials: SL
authors.lastname: Galetta
authors.forename: J
authors.initials: J
authors.lastname: Oh
authors.forename: M
authors.initials: M
authors.lastname: Lango
authors.forename: J J
authors.initials: JJ
authors.lastname: Brooks
authors.forename: S J
authors.initials: SJ
authors.lastname: Schuster
authors.forename: L A
authors.initials: LA
authors.lastname: Loevner
mesh_terms: D004660:Encephalitis / Q000209:etiology / Q000276:immunology / Q000473:pathology; D005260:Female; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000150:complications* / Q000276:immunology; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D011559:Pseudotumor Cerebri / Q000209:etiology* / Q000276:immunology / Q000473:pathology*; D019291:Skull Base / Q000473:pathology*