Pathogen profiling for disease management and surveillance.
The usefulness of rapid pathogen genotyping is widely recognized, but its effective interpretation and application requires integration into clinical and public health decision-making. How can pathogen genotyping data best be translated to inform disease management and surveillance? Pathogen profiling integrates microbial genomics data into communicable disease control by consolidating phenotypic identity-based methods with DNA microarrays, proteomics, metabolomics and sequence-based typing. Sharing data on pathogen profiles should facilitate our understanding of transmission patterns and the dynamics of epidemics.
Sintchenko
Vitali
V
Centre for Infectious Diseases and Microbiology Public Health, Institute of Clinical Pathology and Medical Research, Westmead Hospital, Western Clinical School, The University of Sydney, New South Wales, Australia. vitalis@icpmr.wsahs.nsw.gov.au
Iredell
Jonathan R
JR
Gilbert
Gwendolyn L
GL
D001419:Bacteria / Q000145:classification / Q000235:genetics / Q000472:pathogenicity; D001424:Bacterial Infections / Q000175:diagnosis* / Q000453:epidemiology / Q000382:microbiology / Q000635:transmission; D018407:Bacterial Physiological Phenomena; D019295:Computational Biology; D019468:Disease Management; D005838:Genotype; D006801:Humans; D017053:Infection Control / Q000379:methods*; D017720:Molecular Epidemiology / Q000379:methods*; D014777:Virus Diseases / Q000175:diagnosis* / Q000453:epidemiology / Q000635:transmission / Q000821:virology; D018406:Virus Physiological Phenomena; D014780:Viruses / Q000145:classification / Q000235:genetics / Q000472:pathogenicity