Betacellulin variants and type 2 diabetes in the Old Order Amish.
Betacellulin is a member of the epidermal growth factor (EGF) family and may play a role in islet neogenesis and regeneration. To evaluate whether polymorphisms in this gene are associated with type 2 diabetes (T2DM) and impaired glucose tolerance (IGT), we genotyped 7 previously identified betacellulin variants in Amish subjects with T2DM (n=150), IGT (n=148) and normal glucose tolerance (NGT) (n=361). There were no significant differences in the allele frequencies of the variants among the 3 groups. In an expanded set of 729 nondiabetic Amish subjects, there was no significant association between the betacellulin variants and levels of glucose or insulin either fasting or during a 3 h oral glucose tolerance test, HOMA or insulin secretion index. These results are consistent with previous studies in Caucasian populations and suggest that variants in the betacellulin gene do not play a major role in the development of T2DM in Caucasian populations.
Silver
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KD
University of Maryland School of Medicine, Department of Medicine, Division of Endocrinology, Diabetes and Nutrition,Baltimore, MD 21201, USA. ksilver@medicine.umaryland.edu
Shi
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Mitchell
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D020121:5' Untranslated Regions; D000368:Aged; D019943:Amino Acid Substitution; D066259:Betacellulin; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D005006:Ethnicity / Q000235:genetics*; D005260:Female; D014644:Genetic Variation; D005838:Genotype; D005951:Glucose Tolerance Test; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D044465:White People / Q000235:genetics
D020121:5' Untranslated Regions; C587851:BTC protein, human; D066259:Betacellulin; D036341:Intercellular Signaling Peptides and Proteins