title: Association between serum CRP concentrations with dietary intake in healthy and dyslipidaemic patients.
abstract: Serum CRP concentrations are elevated in subjects at risk of coronary events and in subjects with metabolic syndrome. Although dietary fat and antioxidants are known for their immune-modulating actions, their reported effects on CRP concentrations have been inconsistent. In the present study we have investigated whether dietary constituents are associated with serum CRP concentrations in healthy subjects and patients with dyslipidaemic. Dyslipidaemic subjects (n=238) were recruited from Hospital Outpatient Clinics in Guilford, UK. Apparently healthy subjects (n=188) were recruited from amongst adjacent University and Hospital employees. A validated food frequency questionnaire was used to estimate dietary intake. Dyslipidaemic patients had higher serum CRP [1.25 (0.42-3.26) mg/L] than control subjects [0.50 (0.17-1.42) mg/L] (p<0.001). In the dyslipidaemic patients, approximately 4% of the variation in serum CRP could be explained by dietary cholesterol intake (p = 0.015, 2.8%), and weakly by dietary vitamin C intake (p = 0.06, 1.2%). No relationship between dietary constituents and serum CRP concentrations was found among the healthy subjects. Hence the present study shows that serum CRP concentrations are increased in patients with classical coronary risk factors, and that they may be modulated by dietary cholesterol.
authors.affiliation: Faculty of Medicine, Mashad University of Medical Sciences, Mashad, Iran.
authors.forename: Majid
authors.initials: M
authors.lastname: Ghayour-Mobarhan
authors.forename: Hanyeh
authors.initials: H
authors.lastname: Yaghootkar
authors.forename: Suzan A
authors.initials: SA
authors.lastname: Lanham-New
authors.forename: David J
authors.initials: DJ
authors.lastname: Lamb
authors.forename: Gordon A
authors.initials: GA
authors.lastname: Ferns
mesh_terms: D001205:Ascorbic Acid / Q000008:administration & dosage; D002097:C-Reactive Protein / Q000378:metabolism*; D016022:Case-Control Studies; D002791:Cholesterol, Dietary / Q000008:administration & dosage* / Q000009:adverse effects / Q000378:metabolism; D003327:Coronary Disease / Q000097:blood / Q000453:epidemiology / Q000209:etiology; D004032:Diet; D050171:Dyslipidemias / Q000097:blood*; D015444:Exercise / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D015999:Multivariate Analysis; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D011795:Surveys and Questionnaires; D006113:United Kingdom / Q000453:epidemiology; D014815:Vitamins / Q000008:administration & dosage
chemical_list: D002791:Cholesterol, Dietary; D014815:Vitamins; D002097:C-Reactive Protein; D001205:Ascorbic Acid