title: Validation of numerical simulation with PIV measurements for two anastomosis models.
abstract: Hemodynamics is widely believed to influence coronary artery bypass graft (CABG) stenosis. Although distal anastomosis has been extensively investigated, further studies on proximal anastomosis are still necessary, as the extent and initiation of the stenosis process may be influenced by the flow of the proximal anastomosis per se. Therefore, in this study, two models (i.e. 90 degrees and 135 degrees anastomotic models) were designed and constructed to simulate a proximal anastomosis of CABG for the left and right coronary arteries, respectively. Flow characteristics for these models were studied experimentally in order to validate the simulation results found earlier. PIV measurements were carried out on two Pyrex glass models, so that the disturbed flow (stagnation point, flow separation and vortex) found in both proximal anastomosis models using numerical simulation, could be verified. Consequently, a fair agreement between numerical and experimental data was observed in terms of flow characteristics, velocity profiles and wall shear stress (WSS) distributions under both steady and pulsatile flow conditions. The discrepancy was postulated to be due to the difference in detailed geometry of the physical and computational models, due to manufacturing limitations. It was not possible to reproduce the exact shape of the computational model when making the Pyrex glass model. The analysis of the hemodynamic parameters based on the numerical simulation study also suggested that the 135 degrees proximal anastomosis model would alleviate the potential of intimal thickening and/or atherosclerosis, more than that of a 90 degrees proximal anastomosis model, as it had a lower variation range of time-averaged WSS and the lower segmental average of WSSG.
authors.affiliation: School of Mechanical and Aerospace Engineering, Nanyang Technological University, Singapore 639798, Singapore.
authors.forename: Jun-Mei
authors.initials: JM
authors.lastname: Zhang
authors.forename: Leok Poh
authors.initials: LP
authors.lastname: Chua
authors.forename: Dhanjoo N
authors.initials: DN
authors.lastname: Ghista
authors.forename: Tong-Ming
authors.initials: TM
authors.lastname: Zhou
authors.forename: Yong Seng
authors.initials: YS
authors.lastname: Tan
mesh_terms: D000714:Anastomosis, Surgical; D050197:Atherosclerosis / Q000209:etiology / Q000503:physiopathology / Q000601:surgery; D001698:Biomedical Engineering; D001026:Coronary Artery Bypass; D023903:Coronary Restenosis; D006083:Graft Occlusion, Vascular; D006439:Hemodynamics; D018056:Hemorheology; D006801:Humans; D008955:Models, Cardiovascular; D015233:Models, Statistical; D011673:Pulsatile Flow