title: Inositol phosphoglycan P-type in healthy and preeclamptic pregnancies.
abstract: An association between inositol phosphoglycan P-type (P-IPG) and preeclampsia has been demonstrated over recent years. This molecule can mediate many of the metabolic and growth promoting effects of insulin. Dysregulation of the mediator family is associated with insulin resistance. An increased concentration of P-IPG has been reported in preeclamptic placenta, although its precursor (GPI) was undetectable in those placental samples. Insulin administration, that induces P-IPG release in normal human placenta, was shown not to cause production/release of the mediator from preeclamptic placental tissue as a consequence of a disturbed insulin signalling. Amniotic fluid is enriched of this mediator, with further increase during preeclampsia. We have found that the fetus released increasing amounts of P-IPG in the urine between 13 and 18 weeks of gestation, reaching a plateau beyond 20 weeks. Cord blood of infants of preeclamptic mothers showed an increased content of soluble P-IPG compared to controls and to the mother.
authors.affiliation: Department of Immunology and Molecular Pathology, Molecular Medicine Unit, Royal Free and University College London Medical School, London, UK. marcoscioscia@gmail.com
authors.forename: Marco
authors.initials: M
authors.lastname: Scioscia
authors.forename: Khalid
authors.initials: K
authors.lastname: Gumaa
authors.forename: Melissa
authors.initials: M
authors.lastname: Whitten
authors.forename: Luigi E
authors.initials: LE
authors.lastname: Selvaggi
authors.forename: Charles H
authors.initials: CH
authors.lastname: Rodeck
authors.forename: Thomas W
authors.initials: TW
authors.lastname: Rademacher
mesh_terms: D000653:Amniotic Fluid / Q000378:metabolism*; D005260:Female; D005312:Fetal Blood / Q000378:metabolism; D005333:Fetus / Q000378:metabolism; D006801:Humans; D007295:Inositol Phosphates / Q000097:blood / Q000378:metabolism* / Q000652:urine; D007328:Insulin / Q000378:metabolism; D007333:Insulin Resistance; D010920:Placenta / Q000378:metabolism; D011134:Polysaccharides / Q000097:blood / Q000378:metabolism* / Q000652:urine; D011225:Pre-Eclampsia / Q000097:blood / Q000378:metabolism* / Q000652:urine; D011247:Pregnancy
chemical_list: D007295:Inositol Phosphates; D007328:Insulin; D011134:Polysaccharides; C028039:inositol phosphate glycan