title: Variability in apo(a) gene regulatory sequences, compound genotypes, and association with Lp(a) plasma levels.
abstract: OBJECTIVE
  Lipoprotein(a) is an independent risk factor of atherosclerosis.
  
  
  METHODS
  We assigned frequencies of six polymorphic sites from apo(a) gene transcription control regions, linkage disequilibrium, and 5-polymorphic compound genotypes association with Lp(a) levels.
  
  
  RESULTS
  Significant linkage disequilibrium between polymorphic sites was detected. Compound genotypes were significantly associated with Lp(a) levels (P<0.0001). Major 5-polymorphic genotypes were distributed in a broad range of concentrations.
  
  
  CONCLUSIONS
  Major 5-polymorphic compound genotypes are not associated with restricted range of Lp(a) levels.
authors.affiliation: 3rd Medical Department, 1st Faculty of Medicine and General Teaching Hospital, Charles University, Prague, Czech Republic. kzidk@lfl.cuni.cz
authors.forename: Katerina
authors.initials: K
authors.lastname: Zídková
authors.forename: Lukás
authors.initials: L
authors.lastname: Zlatohlávek
authors.forename: Richard
authors.initials: R
authors.lastname: Ceska
mesh_terms: D001054:Apolipoproteins A / Q000235:genetics*; D001483:Base Sequence; D005838:Genotype; D006801:Humans; D017270:Lipoprotein(a) / Q000097:blood*; D011110:Polymorphism, Genetic / Q000235:genetics*
chemical_list: D001054:Apolipoproteins A; D017270:Lipoprotein(a)