Preparation and application of a novel Pirkle-type chiral stationary phase in liquid chromatography.
A new high-performance liquid chromatographic Pirkle-type chiral stationary phase (CSP) was prepared starting from R-(+)-1,1'-binaphthyl-2,2'-diamine. The CSP prepared was successfully applied in resolving various N-(3,5-dinitrobenzoyl)-alpha-amino amides and N-acyl-1-aryl-1-aminoalkanes and found to be effective. The chiral recognition mechanism was proposed to be pi-pi interaction and simultaneously hydrogen bonding interactions between the CSP and the analytes.
Zhang
Dandan
D
Department of Analytical Chemistry, Shenyang Pharmaceutical University, Shenyang, China. Dandanzhang625@hotmail.com
Li
Famei
F
Hyun
Myung Ho
MH
D000473:Alkanes / Q000302:isolation & purification; D000596:Amino Acids / Q000302:isolation & purification*; D002851:Chromatography, High Pressure Liquid; D006860:Hydrogen Bonding; D007202:Indicators and Reagents; D013237:Stereoisomerism
D000473:Alkanes; D000596:Amino Acids; D007202:Indicators and Reagents