title: Abnormal cortical folding patterns within Broca's area in schizophrenia: evidence from structural MRI.
abstract: We compared cortical folding patterns between patients with schizophrenia and demographically-matched healthy controls in prefrontal and temporal regions of interest. Using the Freesurfer (http://surfer.nmr.mgh.harvard.edu) cortical surface-based reconstruction methodology, we indirectly ascertained cortical displacement and convolution, together, by measuring the degree of metric distortion required to optimally register cortical folding patterns to an average template. An area within the pars triangularis of the left inferior frontal gyrus (Broca's area) showed significantly reduced metric distortion in the patient group relative to the control group (p=0.0352). We discuss these findings in relation to the neurodevelopmental hypothesis and language dysfunction in schizophrenia.
authors.affiliation: MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Building 149 13th Street, Room 2301, Charlestown, MA 02129, United States. jjwisco@mednet.ucla.edu
authors.forename: Jonathan J
authors.initials: JJ
authors.lastname: Wisco
authors.forename: Gina
authors.initials: G
authors.lastname: Kuperberg
authors.forename: Dara
authors.initials: D
authors.lastname: Manoach
authors.forename: Brian T
authors.initials: BT
authors.lastname: Quinn
authors.forename: Evelina
authors.initials: E
authors.lastname: Busa
authors.forename: Bruce
authors.initials: B
authors.lastname: Fischl
authors.forename: Stephan
authors.initials: S
authors.lastname: Heckers
authors.forename: A Gregory
authors.initials: AG
authors.lastname: Sorensen
mesh_terms: D003710:Demography; D005260:Female; D005625:Frontal Lobe / Q000033:anatomy & histology* / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D017397:Prefrontal Cortex / Q000033:anatomy & histology / Q000503:physiopathology; D012559:Schizophrenia / Q000175:diagnosis* / Q000503:physiopathology*; D013702:Temporal Lobe / Q000033:anatomy & histology / Q000503:physiopathology