title: Significance of blood analysis in hemophiliacs co-infected with human immunodeficiency virus and hepatitis viruses.
abstract: OBJECTIVE
  To study the effect of hepatitis virus infection on cirrhosis and liver function markers in HIV-infected hemophiliacs.
  
  
  METHODS
  We have analyzed the immunological, liver function and cirrhosis markers in a cohort of hemophiliacs co-infected with human immunodeficiency virus (HIV) and hepatitis viruses.
  
  
  RESULTS
  There was no difference in immunological markers among co-infected patients and patients infected with HIV only and those co-infected with one or more hepatitis virus. Although liver function and cirrhosis markers remained within a normal range, there was a worsening trend in all patients co-infected with hepatitis virus C (HCV), which was further exacerbated in the presence of additional infection with hepatitis virus B (HBV).
  
  
  CONCLUSIONS
  Co-infection with HIV, HBV and HCV leads to worsening of hyaluronic acid and liver function markers. Increases in serum hyaluronic acid may be suggestive of a predisposition to liver diseases.
authors.affiliation: Shanghai Medical College and Shanghai Public Health Center, Fudan University, Shanghai 201508, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Shen
authors.forename: Qin
authors.initials: Q
authors.lastname: Huang
authors.forename: Hong-Qing
authors.initials: HQ
authors.lastname: Sun
authors.forename: Reena
authors.initials: R
authors.lastname: Ghildyal
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D016516:CD4-CD8 Ratio; D002681:China; D015331:Cohort Studies; D018450:Disease Progression; D015658:HIV Infections / Q000097:blood* / Q000150:complications; D006467:Hemophilia A / Q000097:blood* / Q000150:complications; D006509:Hepatitis B / Q000097:blood* / Q000150:complications; D006526:Hepatitis C / Q000097:blood* / Q000150:complications; D006801:Humans; D006820:Hyaluronic Acid / Q000097:blood; D008099:Liver / Q000378:metabolism / Q000473:pathology / Q000821:virology; D008103:Liver Cirrhosis / Q000097:blood / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D019562:Viral Load
chemical_list: D015415:Biomarkers; D006820:Hyaluronic Acid