[Association of FASL-844 polymorphism with the risk of idiopathic azoospermia and severe oligozoospermia].
OBJECTIVE
To study the distribution of FASL-844 polymorphism in southern Chinese males of Han nationality and examine the contribution of the polymorphism to susceptibility of idiopathic azoospermia and oligozoospermia.


METHODS
FASL-844 polymorphism was genotyped by polymerase chain reaction and restriction fragment length polymorphism(PCR-RFLP) in 184 infertile patients with idiopathic azoospermia or severe oligozoospermia 236 normal fertile male controls.


RESULTS
Frequencies of FASL-844 CT and TT genotypes of the patients were significantly different from those of the controls (P = 0.024; P = 0.008). Males with FASL-844 TT genotype had an increased risk of idiopathic azoospermia or severe oligozoospermia compared with those with CC genotype (OR 2.76, 95% CI: 1.20-6.35), and even a higher risk when compared with those with CC and CT genotypes (OR 2.90, 95% CI: 1.28-6.58).


CONCLUSIONS
FASL-844 polymorphism appears to be a genetic predisposing factor of idiopathic azoospermia or severe oligozoospermia among southern Chinese Han males.
Wang
Wei
W
Department of Urology, the First Affiliated Hospital of Nanjing Medical University, Institute of Applied Toxicology, Nanjing Medical University, Nanjing, Jiangsu 210029, China.
Lu
Ning-xia
NX
Xia
Yan-ai
YA
Wang
Xin-ru
XR
Zhang
Wei
W
Song
Ning-hong
NH
Wei
Min
M
Su
Jian-tang
JT
D000328:Adult; D053713:Azoospermia / Q000235:genetics*; D053222:Fas Ligand Protein / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007248:Infertility, Male / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009845:Oligospermia / Q000235:genetics*; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length
D053222:Fas Ligand Protein