[Cardiovascular peculiarities in hypertensive rats (Hsiah strain) after antihypertensive drug intervention during juvenile period of life].
Treatment with different types of antihypertensive drugs during second month age has not prevented development of arterial hypertension and myocardial hypertrophy in the adult rats with inherited stress-induced arterial hypertension. At 6 months of age, the 11% attenuation of basal blood pressure has beet achieved only in the rats treated with angiotensin-converting enzyme inhibitor enalapril. Nevertheless, they expressed the most pronounced left ventricular hypertrophy. The unfavorable tissue and ultrastructural abnormalities were revealed in the myocardium of the rats which received the alpha1-adrenoceptor blocker terazosin. The delayed effects of losartan (angionetsin II receptor antagonist) and corinfar (calcium channel antagonist) on the myocardial structure were inessential.
Korostyshevskaia
I M
IM
Maksimov
V F
VF
Markel'
A L
AL
Shmerling
M D
MD
Buzueva
I I
II
Filiyshina
E E
EE
Iakobson
G S
GS
D000375:Aging / Q000187:drug effects / Q000473:pathology; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D030342:Genetic Diseases, Inborn; D006973:Hypertension / Q000209:etiology / Q000235:genetics / Q000473:pathology / Q000517:prevention & control*; D017379:Hypertrophy, Left Ventricular / Q000209:etiology / Q000473:pathology; D009206:Myocardium / Q000648:ultrastructure; D051381:Rats; D013312:Stress, Physiological / Q000150:complications / Q000235:genetics; D013997:Time Factors
D000959:Antihypertensive Agents