Integrative pathway knowledge bases as a tool for systems molecular medicine.
There exists a sense of urgency to begin to generate a cohesive assembly of biomedical knowledge as the pace of knowledge accumulation accelerates. The urgency is in part driven by the emergence of systems molecular medicine that emphasizes the combination of systems analysis and molecular dissection in the future of medical practice and research. A potentially powerful approach is to build integrative pathway knowledge bases that link organ systems function with molecules.
Liang
Mingyu
M
Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA. mliang@mcw.edu
D006801:Humans; D051188:Knowledge Bases; D008511:Medicine / Q000379:methods*; D053858:Metabolic Networks and Pathways; D008954:Models, Biological; D008967:Molecular Biology / Q000379:methods*; D015398:Signal Transduction / Q000502:physiology; D049490:Systems Biology / Q000379:methods*; D018511:Systems Integration