Airway smooth muscle dynamics: a common pathway of airway obstruction in asthma.
Excessive airway obstruction is the cause of symptoms and abnormal lung function in asthma. As airway smooth muscle (ASM) is the effecter controlling airway calibre, it is suspected that dysfunction of ASM contributes to the pathophysiology of asthma. However, the precise role of ASM in the series of events leading to asthmatic symptoms is not clear. It is not certain whether, in asthma, there is a change in the intrinsic properties of ASM, a change in the structure and mechanical properties of the noncontractile components of the airway wall, or a change in the interdependence of the airway wall with the surrounding lung parenchyma. All these potential changes could result from acute or chronic airway inflammation and associated tissue repair and remodelling. Anti-inflammatory therapy, however, does not "cure" asthma, and airway hyperresponsiveness can persist in asthmatics, even in the absence of airway inflammation. This is perhaps because the therapy does not directly address a fundamental abnormality of asthma, that of exaggerated airway narrowing due to excessive shortening of ASM. In the present study, a central role for airway smooth muscle in the pathogenesis of airway hyperresponsiveness in asthma is explored.
An
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Division of Physiology, Dept of Environmental Health Sciences, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.
Bai
T R
TR
Bates
J H T
JH
Black
J L
JL
Brown
R H
RH
Brusasco
V
V
Chitano
P
P
Deng
L
L
Dowell
M
M
Eidelman
D H
DH
Fabry
B
B
Fairbank
N J
NJ
Ford
L E
LE
Fredberg
J J
JJ
Gerthoffer
W T
WT
Gilbert
S H
SH
Gosens
R
R
Gunst
S J
SJ
Halayko
A J
AJ
Ingram
R H
RH
Irvin
C G
CG
James
A L
AL
Janssen
L J
LJ
King
G G
GG
Knight
D A
DA
Lauzon
A M
AM
Lakser
O J
OJ
Ludwig
M S
MS
Lutchen
K R
KR
Maksym
G N
GN
Martin
J G
JG
Mauad
T
T
McParland
B E
BE
Mijailovich
S M
SM
Mitchell
H W
HW
Mitchell
R W
RW
Mitzner
W
W
Murphy
T M
TM
Paré
P D
PD
Pellegrino
R
R
Sanderson
M J
MJ
Schellenberg
R R
RR
Seow
C Y
CY
Silveira
P S P
PS
Smith
P G
PG
Solway
J
J
Stephens
N L
NL
Sterk
P J
PJ
Stewart
A G
AG
Tang
D D
DD
Tepper
R S
RS
Tran
T
T
Wang
L
L
D000222:Adaptation, Physiological; D000402:Airway Obstruction / Q000503:physiopathology*; D017209:Apoptosis; D001249:Asthma / Q000503:physiopathology*; D016535:Bronchial Hyperreactivity / Q000503:physiopathology*; D006801:Humans; D009119:Muscle Contraction / Q000502:physiology; D009130:Muscle, Smooth / Q000503:physiopathology*; D012129:Respiratory Function Tests; D015656:Respiratory Mechanics