Fluorous synthesis of sclerotigenin-type benzodiazepine-quinazolinones.
A new synthetic protocol for sclerotigenin-type benzodiazepine-quinazolinone library scaffold is introduced. A fluorous benzyl protecting group is used for synthesis of 4-benzodiazepine-2,5-dione intermediate and also as a phase tag for fluorous solid-phase extraction (F-SPE).
Zhang
Wei
W
Fluorous Technologies, Inc., University of Pittsburgh Applied Research Center, 970 William Pitt Way, Pittsburgh, PA 15238, USA.
Williams
John P
JP
Lu
Yimin
Y
Nagashima
Tadamichi
T
Chu
Qainli
Q