title: [The low weight of the prostate is an independent risk factor for positive surgical margins on radical prostatectomy specimens].
abstract: OBJECTIVE
  The presence of positive surgical margins (PSM) on radical prostatectomy specimen is predictive of biological recurrence. Our objective was to analyze the influence of prostate weight on surgical margins status after radical prostatectomy.
  
  
  METHODS
  A cohort of 295 patients operated consecutively between 1998 and 2004 at our institution was prospectively studied. The variables significantly associated with the surgical margins status in univariate analysis were used for multivariate analysis.
  
  
  RESULTS
  The overall rate of PSM was 23% (9% for pT2 patients). Parameters significantly associated with surgical margins status were preoperative PSA (p = 0.02), number of positive biopsy cores (p = 0.04), pathological stage (p < 0. 001), and Gleason score on radical prostatectomy specimen (p < 0. 001). In addition, patient age and surgical specimen weight were conversely associated with surgical margins status (p = 0.008 and p = 0.001, respectively). In multivariate analysis, only three parameters were found to be independent factors of PSM: the pathological stage (p < 0. 001), the patient age (p = 0. 02), and the surgical specimen weight (p = 0.02). PSM rates were 6% and 25% in patients with prostate > 70g and < 70g, respectively (p = 0.008), and 15% and 28% in those with prostate weight > or = 50g and < 50g, respectively (p = 0.015).
  
  
  CONCLUSIONS
  Low prostate weight is an independent risk factor of PSM. Patients with prostate weight > or = 70g should be considered at low risk of PSM, while those with prostate weight < 50g are at high risk of PSM.
authors.affiliation: Service d'urologie, Hôpital Cochin, Paris. aureliendescazeaud@hotmail.com
authors.forename: Aurélien
authors.initials: A
authors.lastname: Descazeaud
authors.forename: Marc
authors.initials: M
authors.lastname: Zerbib
authors.forename: Annick
authors.initials: A
authors.lastname: Vieillefond
authors.forename: Bernard
authors.initials: B
authors.lastname: Debré
authors.forename: Michaël
authors.initials: M
authors.lastname: Peyromaure
mesh_terms: D000367:Age Factors; D000368:Aged; D001706:Biopsy; D015331:Cohort Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D009367:Neoplasm Staging; D018365:Neoplasm, Residual; D009929:Organ Size; D011446:Prospective Studies; D011467:Prostate / Q000473:pathology*; D017430:Prostate-Specific Antigen / Q000032:analysis; D011468:Prostatectomy / Q000379:methods*; D011471:Prostatic Neoplasms / Q000473:pathology* / Q000601:surgery; D012307:Risk Factors
chemical_list: D017430:Prostate-Specific Antigen