Flavonoids and biological activities of Jussiaea repens.
A new acylated avicularin, namely avicularin 2''-(4'''-O-n-pentanoyl)-gallate (1) along with 12 metabolites have been isolated from the ethyl acetate extract of the aerial parts of Jussiaea repens L. (Onagraceae). Their structures were established as trifolin 2''-O-gallate (2), quercetrin (3), guaijaverin (4), reynoutrin (5), juglanin (6), avicularin (7), hyperin (8), trifolin (9), hyperin 2''-O-gallate (10), rutin (11), kaempferol (12) and quercetin (13) on the basis of their chromatographic properties, chemical and spectroscopic evidences. The investigated ethyl acetate extract was found to be non-toxic (LD(50) up to the maximum soluble dose 4 g kg(-1) body wt.) and had significant antioxidant, hepatoprotective, anti-inflammatory and antidiabetic activities. Also some of the isolated flavonoids showed cytotoxic activity against Ehrlich ascitis carcinoma cells.
Marzouk
M S
MS
Chemistry of Tannins and Leather Technology Department, National Research Centre, El-Dokki, Cairo, Egypt. msmarzouk@yahoo.co.uk
Soliman
F M
FM
Shehata
I A
IA
Rabee
M
M
Fawzy
G A
GA
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology; D005419:Flavonoids / Q000737:chemistry / Q000494:pharmacology*; D005697:Galactosides / Q000737:chemistry / Q000494:pharmacology; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000494:pharmacology; D044949:Kaempferols / Q000737:chemistry / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D015394:Molecular Structure; D029594:Onagraceae / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D011794:Quercetin / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology; D051381:Rats
D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D005419:Flavonoids; D005697:Galactosides; D007004:Hypoglycemic Agents; D044949:Kaempferols; D010936:Plant Extracts; C519462:guaijaverin; C066407:kaempferol-3-O-galactoside; C012526:quercitrin; C041388:avicularin; C006552:kaempferol; D011794:Quercetin