title: [A case of early extrahepatic bile duct cancer showing diffuse growth].
abstract: A 74-year-old woman visited our hospital for a health checkup, and liver dysfunction and cholangiectasis were detected. Further examinations revealed a protruding lesion spreading diffusely from the upper to the lower extra-hepatic bile duct. On a diagnosis of extra-hepatic bile duct cancer, the patient underwent pancreato-duodenectomy with preservation of the pyloric ring. Small papillary denticulate lesions, forming papillary adenocarcinoma, was scattered over a flat granular lesion of atypical hyperplasia. This morphological pattern is rare, and suggests that the cancer cells may have derived from atypical hyperplastic epithelium.
authors.affiliation: Department of Internal Medicine, Sumitomo Besshi Hospital, Japan.
authors.forename: Seiyuu
authors.initials: S
authors.lastname: Suzuki
authors.forename: Shoji
authors.initials: S
authors.lastname: Hirasaki
authors.forename: Eiichiro
authors.initials: E
authors.lastname: Yumoto
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Yamane
authors.forename: Hideaki
authors.initials: H
authors.lastname: Taniguchi
authors.forename: Fusao
authors.initials: F
authors.lastname: Ikeda
authors.forename: Minoru
authors.initials: M
authors.lastname: Matsubara
mesh_terms: D000231:Adenocarcinoma, Papillary / Q000473:pathology / Q000601:surgery*; D000368:Aged; D001650:Bile Duct Neoplasms / Q000473:pathology / Q000601:surgery*; D017734:Bile Ducts, Extrahepatic / Q000473:pathology*; D004386:Duodenum / Q000601:surgery; D005260:Female; D006801:Humans; D010180:Pancreatectomy