Germ cell tumours of the ovary.
Germinal cell tumours represent only 2-5% of all cancers of the ovary. However, the characteristics of the tumour and the patients have some special qualities as high rates of healing goes together with a strong desire to keep fertility intact because this condition occurs in female children and adolescent girls. Neither the prognosis nor the treatment of these tumours is homogeneous; the low incidence is the reason it is hard to develop prospective studies for establishing prognostic factors and specific treatments. The introduction of adjuvant chemotherapy into initial surgery has improved the prognosis of these patients. The BEP scheme has proved to be equally efficient and less toxic than PVB, and for this reason it has become the standard scheme despite the fact that no randomised studies have been carried out. The surgical treatment demands the application of the same principles seen in cytoreduction surgery of epithelial cancers of the ovary (maximum possible cytoreduction), though in many cases hysterectomy and double adnexectomy may be obviated. In view of the rarity of these tumours, it is advisable to work within cooperative groups that may have subgroups for the treatment of rare tumours. This will probably be the only way to move forward in the prospective knowledge of prognostic factors for these tumours.
Guillem
V
V
Fundación Instituto Valenciano de Oncología, Valencia, Spain. vguillem@fivo.org
Poveda
A
A
D000293:Adolescent; D000328:Adult; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use; D014408:Biomarkers, Tumor; D018236:Carcinoma, Embryonal / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology; D002648:Child; D002822:Choriocarcinoma / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology; D018997:Chorionic Gonadotropin, beta Subunit, Human; D004407:Dysgerminoma / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology; D018240:Endodermal Sinus Tumor / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology; D005260:Female; D006801:Humans; D009367:Neoplasm Staging; D009373:Neoplasms, Germ Cell and Embryonal / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology / Q000601:surgery; D010051:Ovarian Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology / Q000601:surgery; D010053:Ovary / Q000473:pathology; D011379:Prognosis; D016032:Randomized Controlled Trials as Topic; D013724:Teratoma / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology; D014944:World Health Organization; D000509:alpha-Fetoproteins
D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor; D018997:Chorionic Gonadotropin, beta Subunit, Human; D000509:alpha-Fetoproteins