A state-of-the-art cyanation of aryl bromides: a novel and versatile copper catalyst system inspired by Nature.
A general protocol for the cyanation of aryl halides with the nontoxic cyanide source K4[Fe(CN)6] using copper catalysis and a ligand system based on 1-alkylimidazoles is presented. The advantages of this system are the high selectivity, a unique substrate range, easy handling, and inexpensive reagents.
Schareina
Thomas
T
Leibniz-Institut für Katalyse e.V. an der Universität Rostock, Albert-Einstein-Strasse 29 A, 18059 Rostock, Germany.
Zapf
Alexander
A
Mägerlein
Wolfgang
W
Müller
Nikolaus
N
Beller
Matthias
M
D001965:Bromides / Q000737:chemistry*; D001969:Bromobenzenes / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D003486:Cyanides / Q000737:chemistry*; D015394:Molecular Structure
D001965:Bromides; D001969:Bromobenzenes; D003486:Cyanides; D003300:Copper; C032036:bromobenzene