title: Building epidemiological models from R0: an implicit treatment of transmission in networks.
abstract: Simple deterministic models are still at the core of theoretical epidemiology despite the increasing evidence for the importance of contact networks underlying transmission at the individual level. These mean-field or 'compartmental' models based on homogeneous mixing have made, and continue to make, important contributions to the epidemiology and the ecology of infectious diseases but fail to reproduce many of the features observed for disease spread in contact networks. In this work, we show that it is possible to incorporate the important effects of network structure on disease spread with a mean-field model derived from individual level considerations. We propose that the fundamental number known as the basic reproductive number of the disease, R0, which is typically derived as a threshold quantity, be used instead as a central parameter to construct the model from. We show that reliable estimates of individual level parameters can replace a detailed knowledge of network structure, which in general may be difficult to obtain. We illustrate the proposed model with small world networks and the classical example of susceptible-infected-recovered (SIR) epidemics.
authors.affiliation: Department of Science and Technology, Universidad Metropolitana, San Juan 00928-1150, Puerto Rico. juan.p.aparicio@gmail.com
authors.forename: Juan Pablo
authors.initials: JP
authors.lastname: Aparicio
authors.forename: Mercedes
authors.initials: M
authors.lastname: Pascual
mesh_terms: D003198:Computer Simulation; D004196:Disease Outbreaks; D018562:Disease Transmission, Infectious; D008954:Models, Biological; D015233:Models, Statistical; D011157:Population Dynamics; D011634:Public Health; D013269:Stochastic Processes