Dual infection with polyomavirus BK and acyclovir-resistant herpes simplex virus successfully treated with cidofovir in a bone marrow transplant recipient.
A hematopoietic stem cell transplant recipient developed a mucosal herpes simplex virus-1 (HSV-1) infection while under acyclovir (ACV) treatment (HSV was later shown to be resistant to ACV). Concomitantly, the patient presented a hemorrhagic cystitis (HC) due to polyomavirus BK, for which intravenous cidofovir (CDV) was prescribed. The patient benefited from the broad-spectrum anti-DNA virus activity of CDV, and not only the HC resolved without signs of nephrotoxicity but also the HSV-1 lesions disappeared. This is the first report describing the effect of CDV on 2 simultaneous and unrelated DNA viral infections in an immunosuppressed transplant recipient. In addition, we describe here that this HSV-1 isolate possesses a unique phenotype and genotype.
Andrei
G
G
Laboratory of Virology, Rega Institute for Medical Research, K.U. Leuven, Leuven, Belgium.
Fiten
P
P
Goubau
P
P
van Landuyt
H
H
Gordts
B
B
Selleslag
D
D
De Clercq
E
E
Opdenakker
G
G
Snoeck
R
R
D000212:Acyclovir / Q000627:therapeutic use*; D000293:Adolescent; D000998:Antiviral Agents / Q000627:therapeutic use*; D001739:BK Virus; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D000077404:Cidofovir; D003596:Cytosine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D024882:Drug Resistance, Viral; D005260:Female; D006561:Herpes Simplex / Q000150:complications / Q000188:drug therapy*; D018259:Herpesvirus 1, Human / Q000302:isolation & purification*; D006801:Humans; D063065:Organophosphonates / Q000627:therapeutic use*; D027601:Polyomavirus Infections / Q000150:complications / Q000188:drug therapy*; D014412:Tumor Virus Infections / Q000150:complications / Q000188:drug therapy*
D000998:Antiviral Agents; D063065:Organophosphonates; D003596:Cytosine; D000077404:Cidofovir; D000212:Acyclovir