Hsp27 (HspB1) and alphaB-crystallin (HspB5) as therapeutic targets.
Hsp27 and alphaB-crystallin are molecular chaperones that are constitutively expressed in several mammalian cells, particularly in pathological conditions. These proteins share functions as diverse as protection against toxicity mediated by aberrantly folded proteins or oxidative-inflammation conditions. In addition, these proteins share anti-apoptotic properties and are tumorigenic when expressed in cancer cells. This review summarizes the current knowledge about Hsp27 and alphaB-crystallin and the implications, either positive or deleterious, of these proteins in pathologies such as neurodegenerative diseases, myopathies, asthma, cataracts and cancers. Approaches towards therapeutic strategies aimed at modulating the expression and/or the activities of Hsp27 and alphaB-crystallin are presented.
Arrigo
André-Patrick
AP
Laboratoire Stress, Chaperons et Mort Cellulaire, CNRS, UMR5534, Centre de Génétique Moléculaire et Cellulaire, Université Lyon 1, Bat. Gregor Mendel, 16 Rue Dubois, F-69622, Villeurbanne Cedex, France. arrigo@univ-lyon1.fr
Simon
Stéphanie
S
Gibert
Benjamin
B
Kretz-Remy
Carole
C
Nivon
Mathieu
M
Czekalla
Anna
A
Guillet
Dominique
D
Moulin
Maryline
M
Diaz-Latoud
Chantal
C
Vicart
Patrick
P
D055551:HSP27 Heat-Shock Proteins; D006360:Heat-Shock Proteins / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D007249:Inflammation / Q000188:drug therapy* / Q000378:metabolism; D018832:Molecular Chaperones / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism*; D009363:Neoplasm Proteins / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism*; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D011487:Protein Conformation; D038203:alpha-Crystallin B Chain / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism*
C059215:CRYAB protein, human; D055551:HSP27 Heat-Shock Proteins; C057725:HSPB1 protein, human; D006360:Heat-Shock Proteins; D018832:Molecular Chaperones; D009363:Neoplasm Proteins; D038203:alpha-Crystallin B Chain