title: Giant cell lesions with a Noonan-like phenotype: a case report.
abstract: OBJECTIVE
  The purpose of this article is to describe a case of multiple giant cell lesions of the mandible that occurred in a 14-year-old girl with phenotypic characteristics associated with Noonan Syndrome (NS).
  
  
  BACKGROUND
  NS is a dysmorphic disorder characterized by hypertelorism, short stature, congenital heart defects, short and webbed neck, skeletal anomalies, and bleeding diathesis.
  
  
  METHODS
  A 14-year-old girl with a previous diagnosis of NS (sporadic case) presented with multiple radiolucent lesions in the body and ramus of her mandible.
  
  
  CONCLUSIONS
  In terms of clinical behavior and the described radiographic characteristics, giant cells lesions with Noonan-like phenotype can be considered a form of cherubism. Therefore, surgical intervention is not necessary, but radiographic follow-up and observation is very important during the control and gradual regression of the lesions.
authors.affiliation: Porto Alegre, RS, Brazil. marcelaforerocancino@hotmail.com
authors.forename: Claudia Marcela H
authors.initials: CM
authors.lastname: Cancino
authors.forename: Léonilson
authors.initials: L
authors.lastname: Gaião
authors.forename: Manoel
authors.initials: M
authors.lastname: Sant'Ana Filho
authors.forename: Flavio Augusto Marsiaj
authors.initials: FA
authors.lastname: Oliveira
mesh_terms: D000293:Adolescent; D002636:Cherubism / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology; D005260:Female; D015726:Giant Cells / Q000473:pathology*; D006801:Humans; D008336:Mandibular Diseases / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology; D009634:Noonan Syndrome / Q000150:complications*; D011859:Radiography; D012075:Remission, Spontaneous