title: Age-specific salivary immunoglobulin A response to Streptococcus mutans GbpB.
abstract: In a follow-up study of children infected with Streptococcus mutans at an early age (children previously shown to respond poorly to S. mutans GbpB), there was a delay in their immune response, rather than a complete inability to respond to this antigen. Epitopes in the N-terminal third of GbpB were identified as targets for naturally induced immunoglobulin A antibody in children at an early age.
authors.affiliation: Department of Oral Diagnosis, Piracicaba School of Dentistry, State University of Campinas, Piracicaba, São Paulo, Brazil.
authors.forename: Ruchele D
authors.initials: RD
authors.lastname: Nogueira
authors.forename: Alessandra C
authors.initials: AC
authors.lastname: Alves
authors.forename: William F
authors.initials: WF
authors.lastname: King
authors.forename: Reginaldo B
authors.initials: RB
authors.lastname: Gonçalves
authors.forename: José F
authors.initials: JF
authors.lastname: Höfling
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Smith
authors.forename: Renata O
authors.initials: RO
authors.lastname: Mattos-Graner
mesh_terms: D000367:Age Factors; D016022:Case-Control Studies; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D019084:Fluorescent Antibody Technique, Indirect; D005500:Follow-Up Studies; D006801:Humans; D007071:Immunoglobulin A, Secretory / Q000032:analysis* / Q000276:immunology; D008137:Longitudinal Studies; D012463:Saliva / Q000276:immunology*; D013290:Streptococcal Infections / Q000276:immunology*; D013295:Streptococcus mutans / Q000276:immunology*
chemical_list: D007071:Immunoglobulin A, Secretory