Influence of water soluble polymers on hydroxypropyl-beta-cyclodextrin complexation of rofecoxib.
Rofecoxib (Rb) is a nonsteroidal anti-inflammatory drug (NSAID) with poor aqueous solubility. The present study was undertaken to investigate the influence of water-soluble polymers namely sodium carboxymethyl cellulose (Na CMC), polyvinylpyrrolidine (PVP) and polyethylene glycol (PEG-6000) on hydroxypropyl beta-cyclodextrin (HP beta-CD) complexation of Rb. The complexes were prepared by kneading, autoclaving and precipitation techniques in 1:1 and 1:2 molar ratios. The aqueous solubility enhancement of Rb by these polymers is found to be of the following order: Na CMC > PVP > PEG-6000. Complexes were characterized by Fourier transform infrared (FTIR) spectroscopy, Nuclear magnetic resonance (NMR) and X-ray diffractometry (XRD) techniques. In vitro dissolution studies were carried out on tablets formulated from molar ratios of the complexes prepared by different techniques.
Singh
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Akal College of Pharmacy and Technical Education, Mastuana Sahib, Sangrur, India.
Aboul-Enein
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D000073738:2-Hydroxypropyl-beta-cyclodextrin; D002266:Carboxymethylcellulose Sodium / Q000737:chemistry; D018360:Crystallography, X-Ray; D052246:Cyclooxygenase 2 Inhibitors / Q000737:chemistry*; D004339:Drug Compounding; D065347:Hypromellose Derivatives; D007700:Kinetics; D007783:Lactones / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008747:Methylcellulose / Q000031:analogs & derivatives / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D011205:Povidone / Q000737:chemistry; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D013450:Sulfones / Q000737:chemistry*; D014867:Water; D047392:beta-Cyclodextrins / Q000737:chemistry*
D052246:Cyclooxygenase 2 Inhibitors; D007783:Lactones; D011108:Polymers; D013450:Sulfones; D047392:beta-Cyclodextrins; D014867:Water; C116926:rofecoxib; D000073738:2-Hydroxypropyl-beta-cyclodextrin; D065347:Hypromellose Derivatives; D008747:Methylcellulose; D011205:Povidone; D002266:Carboxymethylcellulose Sodium