Study of retention parameters obtained in RP-TLC system and their application on QSAR/QSPR of some alpha adrenergic and imidazoline receptor ligands.
The retention constant (R(0)(m)) is determined for 11 selected adrenergic and imidazoline receptor ligands by reverse-phase-thin layer chromatography. It is established that the retention behavior of investigated compounds mostly depends on geometrical, electrostatic, and hydrogen bonding properties. Good correlations among hydrophobic parameters R(0)(m) versus log P for all eleven tested compounds are obtained. The satisfactory correlations are found between R(0)(m) versus apparent partition coefficient octanol-buffer pH 7.4 (log P') or apparent partition coefficient in four liposome systems (log K'(M)) and hypotensive activity (pC(25)) for five imidazolines. The results confirm the suitability of this parameter in quantitative structure-property and structure-activity relationships studies of these drugs.
Eríc
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S
Faculty of Pharmacy, University of Belgrade, P.O. Box 146, Vojvode Stepe 450, 11000 Belgrade, Serbia and Montenegro.
Pavlović
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M
Popović
G
G
Agbaba
D
D
D000322:Adrenergic Agonists / Q000302:isolation & purification*; D000316:Adrenergic alpha-Agonists / Q000302:isolation & purification / Q000378:metabolism; D002855:Chromatography, Thin Layer / Q000379:methods*; D057927:Hydrophobic and Hydrophilic Interactions; D054755:Imidazoline Receptors; D021281:Quantitative Structure-Activity Relationship; D011955:Receptors, Drug / Q000819:agonists* / Q000378:metabolism
D000322:Adrenergic Agonists; D000316:Adrenergic alpha-Agonists; D054755:Imidazoline Receptors; D011955:Receptors, Drug