Erasmus Darwin's enlightened views on placental function.
In his major work "Zoonomia", Erasmus Darwin (1731-1802) devoted one chapter to the placenta, in which the new knowledge of the recently discovered element oxygen was applied to the functioning of this organ. He considered the "cavities" or "lacunae" in the placenta as the main areas for oxygenation of the fetal blood, as he thought them to be structurally comparable to the lungs and the gills of fish. He obviously was aware of species differences in the uterine arterial blood supply to the placenta between humans and cows, assuming a higher contractility of the vasculature in the latter species. The new evidence for a primarily respiratory role overshadowed ideas of a possible nutritive function of the placenta. Since Hunter's definitive demonstration of separate maternal and fetal blood circulations, nutritive functions of the placenta needed to be explained by transmembrane transport processes, which were unknown at that time. Instead Erasmus Darwin erroneously considered the amniotic fluid as the main source of nutrients for the fetus. His understanding of placental respiration found expression in his long poem on the history of life on earth.
Pijnenborg
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Department of Gynaecology and Obstetrics, Katholieke Universiteit Leuven, Universitair Ziekenhuis Gasthuisberg, B3000 Leuven, Belgium. robert.pijnenborg@uz.kuleuven.ac.be
Vercruysse
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D000818:Animals; D001692:Biological Transport; D005333:Fetus / Q000378:metabolism; D006801:Humans; D010920:Placenta / Q000378:metabolism; D012641:Selection, Genetic; D014599:Uterus / Q000098:blood supply