The long-term effect of AHSCT on MRI measures of MS evolution: a five-year follow-up study.
Using MRI, we measured disease activity and brain atrophy in nine multiple sclerosis patients treated with autologous hematopoietic stem cell transplantation (AHSCT) for a mean follow up of 63 months. We show that AHSCT is associated to a longlasting suppression of inflammation and to a marked decrease of the rate of brain atrophy after the second year following treatment.
Roccatagliata
L
L
Department of Neuroscience, Ophtalmology and Genetics, University of Genoa, Genoa.
Rocca
Ma
M
Valsasina
P
P
Bonzano
L
L
Sormani
Mp
M
Saccardi
R
R
Mancardi
Gl
G
Filippi
M
M
D000328:Adult; D017668:Age of Onset; D001284:Atrophy; D001921:Brain / Q000473:pathology; D003520:Cyclophosphamide / Q000627:therapeutic use; D005500:Follow-Up Studies; D019650:Hematopoietic Stem Cell Mobilization / Q000379:methods; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007249:Inflammation / Q000517:prevention & control; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000473:pathology* / Q000628:therapy*; D014182:Transplantation, Autologous
D003520:Cyclophosphamide