The Fanconi family adds a fraternal twin.
The Fanconi anemia (FA) pathway plays an important role in DNA repair. In a recent issue of Cell, Smogorzewska et al. (2007) now demonstrate that FANCD2 has a paralog, FANCI. FANCI and FANCD2 form the "ID" complex that loads onto chromatin after DNA damage. Like FANCD2, monoubiquitination of FANCI requires the FA core complex. Importantly, FANCI and FANCD2 monoubiquitination is co-dependent, suggesting a novel mechanism in ubiquitin conjugation.
Grompe
Markus
M
Oregon Stem Cell Center, Oregon Health Science University, 3181 S.W. Sam Jackson Park Road, Mail Code L321, Portland, OR 97239, USA. grompem@ohsu.edu
van de Vrugt
Henri
H
D000818:Animals; D002645:Chickens; D004249:DNA Damage; D052236:Fanconi Anemia Complementation Group D2 Protein / Q000378:metabolism; D051856:Fanconi Anemia Complementation Group Proteins / Q000378:metabolism*; D005198:Fanconi Syndrome / Q000378:metabolism*; D006801:Humans; D011485:Protein Binding; D017386:Sequence Homology, Amino Acid; D025801:Ubiquitin / Q000378:metabolism
C519921:FANCI protein, human; D052236:Fanconi Anemia Complementation Group D2 Protein; D051856:Fanconi Anemia Complementation Group Proteins; D025801:Ubiquitin