Diagnostic ability of the Heidelberg retina tomograph, optical coherence tomograph, and scanning laser polarimeter in open-angle glaucoma.
OBJECTIVE
To compare the ability to discriminate between healthy and glaucomatous eyes of different criteria based on parameters from 3 optical imaging devices: Heidelberg retina tomograph (HRT-II), optical coherence tomograph (Stratus OCT 3000) and scanning laser polarimeter (GDx VCC).


METHODS
Cross-sectional study.


METHODS
A total of 139 eyes from 139 subjects were enrolled in this study and classified into 66 healthy subjects and 73 glaucomatous patients according to intraocular pressure and standard automated perimetry.


METHODS
All the subjects underwent complete ophthalmic examination, including HRT-II, OCT, and GDx VCC evaluations.


METHODS
Several parameters were obtained by these techniques and 8 diagnostic criteria were assessed. Receiver operating characteristics curves were plotted and compared among them, and sensitivity for specificity higher than 95% was calculated for every criterion. Agreement among the 3 technologies was assessed by means of Venn diagrams.


RESULTS
The best criteria discriminating between healthy and glaucomatous eyes were Moorfields regression analysis out of the 95% confidence interval (HRT-II), OCT retinal nerve fiber layer average thickness <77 microm, and nerve fiber indicator >37 (GDx VCC) with sensitivities of 85%, 66%, and 48%, with specificity higher than 95%. Sixty-six patients out of 73 were correctly identified by at least 1 of the devices and 30 were detected by the 3 of them.


CONCLUSIONS
Structural criteria assessed by the optical imaging devices evaluated in this study are useful to discriminate glaucomatous damage.
Pueyo
Victoria
V
Ophthalmology Department, Miguel Servet University Hospital, Zaragoza, Spain. vicpueyo@hotmail.com
Polo
Vicente
V
Larrosa
Jose Manuel
JM
Ferreras
Antonio
A
Pablo
Luis Emilio
LE
Honrubia
Francisco Manuel
FM
D016001:Confidence Intervals; D003430:Cross-Sectional Studies; D003941:Diagnostic Techniques, Ophthalmological; D005260:Female; D005902:Glaucoma, Open-Angle / Q000175:diagnosis*; D006801:Humans; D007429:Intraocular Pressure; D007834:Lasers; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology; D009901:Optic Nerve Diseases / Q000175:diagnosis*; D012372:ROC Curve; D015203:Reproducibility of Results; D012165:Retinal Ganglion Cells / Q000473:pathology; D012680:Sensitivity and Specificity; D041623:Tomography, Optical Coherence / Q000379:methods; D014794:Visual Fields