title: Multiple whole genome alignments and novel biomedical applications at the VISTA portal.
abstract: The VISTA portal for comparative genomics is designed to give biomedical scientists a unified set of tools to lead them from the raw DNA sequences through the alignment and annotation to the visualization of the results. The VISTA portal also hosts the alignments of a number of genomes computed by our group, allowing users to study the regions of their interest without having to manually download the individual sequences. Here we describe various algorithmic and functional improvements implemented in the VISTA portal over the last 2 years. The VISTA Portal is accessible at http://genome.lbl.gov/vista.
authors.affiliation: Department of Computer Science, Banting and Best Department of Medical Research, University of Toronto, 6 King's College Road, Toronto, ON, Canada M5S 3G4.
authors.forename: Michael
authors.initials: M
authors.lastname: Brudno
authors.forename: Alexander
authors.initials: A
authors.lastname: Poliakov
authors.forename: Simon
authors.initials: S
authors.lastname: Minovitsky
authors.forename: Igor
authors.initials: I
authors.lastname: Ratnere
authors.forename: Inna
authors.initials: I
authors.lastname: Dubchak
mesh_terms: D000818:Animals; D001483:Base Sequence; D002645:Chickens; D019295:Computational Biology / Q000379:methods*; D004285:Dogs; D015894:Genome, Human; D023281:Genomics; D006801:Humans; D020407:Internet; D008969:Molecular Sequence Data; D020641:Polymorphism, Single Nucleotide; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA; D012689:Sequence Homology, Nucleic Acid; D012984:Software