title: Benzopyran sulfonamides as KV1.5 potassium channel blockers.
abstract: K(V)1.5 blockers have the potential to be atrium-selective agents for treatment of atrial fibrillation. The benzopyrans provide a template for the synthesis of potent and selective K(V)1.5 blockers.
authors.affiliation: Bristol-Myers Squibb Pharmaceutical Research Institute, PO Box 5400, Princeton, NJ 08543-5400, USA. john.lloyd@bms.com
authors.forename: John
authors.initials: J
authors.lastname: Lloyd
authors.forename: Karnail S
authors.initials: KS
authors.lastname: Atwal
authors.forename: Heather J
authors.initials: HJ
authors.lastname: Finlay
authors.forename: Michael
authors.initials: M
authors.lastname: Nyman
authors.forename: Tram
authors.initials: T
authors.lastname: Huynh
authors.forename: Rao
authors.initials: R
authors.lastname: Bhandaru
authors.forename: Alexander
authors.initials: A
authors.lastname: Kover
authors.forename: Joan
authors.initials: J
authors.lastname: Schmidt
authors.forename: Wayne
authors.initials: W
authors.lastname: Vaccaro
authors.forename: Mary Lee
authors.initials: ML
authors.lastname: Conder
authors.forename: Tonya
authors.initials: T
authors.lastname: Jenkins-West
authors.forename: Paul
authors.initials: P
authors.lastname: Levesque
mesh_terms: D001281:Atrial Fibrillation / Q000188:drug therapy*; D016275:Atrial Function / Q000187:drug effects* / Q000502:physiology; D001578:Benzopyrans / Q000737:chemistry / Q000494:pharmacology*; D051666:Kv1.5 Potassium Channel / Q000187:drug effects* / Q000378:metabolism; D008956:Models, Chemical; D026902:Potassium Channel Blockers / Q000138:chemical synthesis / Q000494:pharmacology*; D013449:Sulfonamides / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D001578:Benzopyrans; D051666:Kv1.5 Potassium Channel; D026902:Potassium Channel Blockers; D013449:Sulfonamides