title: A new steroid glycoside and furochromones from Cyperus rotundus L.
abstract: Further phytochemical investigation of the aerial parts of Cyperus rotundus L. afforded a new steroid glycoside named sitosteryl (6'-hentriacontanoyl)-beta-D-galactopyranoside (4) in addition to three furochromones, khellin (2), visnagin (3) and ammiol (9). Furthermore, benzo-alpha-pyrone (coumarin) (1), salicylic acid (5), caffeic acid (6), protocatechuic acid (7), p-coumaric acid (8), tricin (10) and isorhamnetin (11) were isolated. The structures of these compounds were established by spectroscopic methods. The isolated furochromones were tested for insect antifeedant activity against larvae Spodoptera littoralis when incorporated in artificial diet and offered to larvae in a chronic feeding bioassay. Also, visnagin, khellin and sitosteryl (6'-hentriacontanoyl)-beta-D-galactopyranoside showed strong cytotoxic activity against L5178y mouse lymphoma cells and were also active in the brine shrimp lethality test.
authors.affiliation: Faculty of Pharmacy, Pharmacognosy Department, Assiut University. Assiut 71526. Egypt.
authors.forename: Hanaa M
authors.initials: HM
authors.lastname: Sayed
authors.forename: Mahmoud H
authors.initials: MH
authors.lastname: Mohamed
authors.forename: Salwa F
authors.initials: SF
authors.lastname: Farag
authors.forename: Gamal A
authors.initials: GA
authors.lastname: Mohamed
authors.forename: Peter
authors.initials: P
authors.lastname: Proksch
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001156:Artemia; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D002867:Chromones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D029786:Cyperus / Q000737:chemistry*; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007306:Insecticides / Q000737:chemistry / Q000302:isolation & purification*; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D009904:Optical Rotation; D010936:Plant Extracts / Q000737:chemistry; D012855:Sitosterols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D021241:Spectrometry, Mass, Electrospray Ionization; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D013056:Spectrophotometry, Ultraviolet; D018411:Spodoptera
chemical_list: D000970:Antineoplastic Agents; D002867:Chromones; D006027:Glycosides; D007306:Insecticides; D010936:Plant Extracts; D012855:Sitosterols