[The current opinion on inflammatory, biochemistry and hemostatic markers and factors in atherosclerosis. Part I].
Atherosclerosis remains the leading cause of morbidity and mortality in many countries. Recent studies have established an immuno-inflammatory theory of atherosclerosis where the process of atherosclerosis has a chronic, fibroproliferative character as an immuno-inflammatory response to factors that damage vessel endothelium. The development of coronary artery disease in subjects without traditional risk factors has prompted a search for new markers of the disease, which may improve primary prevention strategies. The relationship between markers of chronic inflammation and infection and development and progression of atherosclerotic may provide a basis for establishing new methods for causative treatment of cardiovascular diseases. The markers of endothelial damage and activation of inflammatory response have a prognostic value independent of traditional risk factors.
Rajtar
Renata
R
II Klinika Kardiologii Instytutu Kardiologii, Collegium Medicum Uniwersytetu Jagiellońskiego, Kraków.
Kloch
Małgorzata
M
Bober
Maria
M
Kolasińska-Kloch
Władysława
W
D050197:Atherosclerosis / Q000453:epidemiology* / Q000276:immunology* / Q000628:therapy; D001323:Autoantibodies / Q000276:immunology; D015415:Biomarkers / Q000378:metabolism; D002097:C-Reactive Protein / Q000378:metabolism; D015984:Causality; D002986:Clinical Trials as Topic / Q000592:standards / Q000639:trends*; D015897:Comorbidity; D005340:Fibrinogen / Q000378:metabolism; D006487:Hemostasis / Q000276:immunology*; D006801:Humans; D007239:Infections / Q000453:epidemiology / Q000276:immunology; D007249:Inflammation / Q000453:epidemiology / Q000276:immunology*; D008954:Models, Biological; D012307:Risk Factors; D014657:Vasculitis / Q000453:epidemiology / Q000276:immunology*
D001323:Autoantibodies; D015415:Biomarkers; D005340:Fibrinogen; D002097:C-Reactive Protein