title: New oxypregnane glycosides from appetite suppressant herbal supplement Hoodia gordonii.
abstract: Hoodigosides A-K (1-11), eleven new oxypregnane glycosides and a previously reported oxypregnane glycoside P57AS3 were isolated from the aerial parts of Hoodia gordonii. The structures of these 12-O-beta-tigloyl isoramanone glycosides were determined on the basis of chemical evidence and extensive spectroscopic methods that include one-dimensional and two-dimensional NMR. Cytotoxicity and antioxidant activities of these compounds were tested in cell based assays where they were found to be inactive.
authors.affiliation: National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, University of Mississippi, University, MS 38677, USA.
authors.forename: Rahul S
authors.initials: RS
authors.lastname: Pawar
authors.forename: Yatin J
authors.initials: YJ
authors.lastname: Shukla
authors.forename: Shabana I
authors.initials: SI
authors.lastname: Khan
authors.forename: Bharathi
authors.initials: B
authors.lastname: Avula
authors.forename: Ikhlas A
authors.initials: IA
authors.lastname: Khan
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D000975:Antioxidants / Q000494:pharmacology; D029062:Apocynaceae / Q000737:chemistry*; D001067:Appetite Depressants; D002240:Carbohydrate Sequence; D006027:Glycosides / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D000970:Antineoplastic Agents; D000975:Antioxidants; D001067:Appetite Depressants; D006027:Glycosides