title: One-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones using chloroacetic acid as catalyst.
abstract: A simple and effective synthesis of 3,4-dihydropyrimidin-2(1H)-one derivatives from aldehydes, 1,3-dicarbonyl compounds and urea or thiourea using chloroacetic acid as catalyst under solvent-free conditions is described. Compared with the classical Biginelli reaction conditions, this new method has the advantage of good to excellent yields and short reaction time.
authors.affiliation: Department of Chemistry, Liaoning University of Petroleum and Chemical Technology, Fushun, Liaoning 113001, PR China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Yu
authors.forename: Di
authors.initials: D
authors.lastname: Liu
authors.forename: Chunsheng
authors.initials: C
authors.lastname: Liu
authors.forename: Genxiang
authors.initials: G
authors.lastname: Luo
mesh_terms: D000085:Acetates / Q000737:chemistry*; D000447:Aldehydes / Q000737:chemistry; D002121:Calcium Channel Blockers / Q000138:chemical synthesis* / Q000494:pharmacology; D002384:Catalysis; D008956:Models, Chemical; D013890:Thiourea / Q000737:chemistry; D014508:Urea / Q000737:chemistry
chemical_list: D000085:Acetates; D000447:Aldehydes; D002121:Calcium Channel Blockers; C006972:chloroacetic acid; D014508:Urea; D013890:Thiourea