title: Cadmium cation increases the production and mRNA levels of insulin-like growth factor-binding protein-1 in HepG2.
abstract: The production of insulin-like growth factor-binding protein-1 (IGFBP-1) in HepG2 was increased by cadmium cation (Cd2+) at 3 microM, but not by other divalent cations. The mRNA level of IGFBP-1 was also increased by the administration of 3 microM of Cd(2+). These results suggest that Cd(2+) impacts the gene expression of IGFBP-1, which leads to production of IGFBP-1.
authors.affiliation: Department of Nutritional Sciences, Faculty of Applied Bioscience, Tokyo University of Agriculture, Tokyo, Japan. y3oishi@nodai.ac.jp
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Oishi
authors.forename: Motoko
authors.initials: M
authors.lastname: Ohnishi
authors.forename: Kazuo
authors.initials: K
authors.lastname: Kobayashi-Hattori
authors.forename: Toshichika
authors.initials: T
authors.lastname: Takita
authors.forename: Tadashi
authors.initials: T
authors.lastname: Noguchi
mesh_terms: D002104:Cadmium / Q000494:pharmacology*; D006528:Carcinoma, Hepatocellular / Q000378:metabolism* / Q000473:pathology; D002412:Cations / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005562:Formazans / Q000378:metabolism; D006801:Humans; D018970:Insulin-Like Growth Factor Binding Protein 1 / Q000096:biosynthesis*; D008113:Liver Neoplasms / Q000378:metabolism* / Q000473:pathology; D012333:RNA, Messenger / Q000378:metabolism*; D013778:Tetrazolium Salts / Q000378:metabolism; D013997:Time Factors
chemical_list: D002412:Cations; D005562:Formazans; D018970:Insulin-Like Growth Factor Binding Protein 1; D012333:RNA, Messenger; D013778:Tetrazolium Salts; D002104:Cadmium; C079782:MTT formazan