Effects of mutant Drosophila K+ channel subunits on habituation of the olfactory jump response.
The olfactory-jump response assay was used to analyze habituation in Drosophila mutants of potassium (K(+)) channel subunits. As with physiological assays of the giant fiber-mediated escape reflex, mutations at loci that encode K(+) channel subunits have distinct effects on habituating the olfactory-jump response. The data for slowpoke and ether à go-go indicate similar effects on habituation of the olfactory-jump response and the giant fiber-mediated escape. Habituation in the olfactory jump assay in Hyperkinetic and Shaker mutants was drastically different from the degree of defect in the giant fiber-mediated escape reflex, indicating differential control mechanisms underlying the two forms of non-associative conditioning.
Joiner
M A
MA
Department of Biological Sciences, University of Iowa, Iowa City, IA 52242, USA.
Asztalos
Z
Z
Jones
C J
CJ
Tully
T
T
Wu
C-F
CF
D000818:Animals; D003214:Conditioning, Classical; D029721:Drosophila Proteins / Q000235:genetics*; D004331:Drosophila melanogaster / Q000235:genetics*; D017344:Genes, Insect; D006185:Habituation, Psychophysiologic; D009154:Mutation; D009473:Neuronal Plasticity; D015221:Potassium Channels / Q000235:genetics*; D012903:Smell
D029721:Drosophila Proteins; D015221:Potassium Channels