title: Arterial plasma vasopressin and aldosterone predict left ventricular mass in men who develop hypertension over 20 years.
abstract: Left ventricular (LV) hypertrophy is related to blood pressure level and neurohormonal factors. The authors previously demonstrated that arterial norepinephrine levels predict LV mass in middle-aged men who developed hypertension through 20 years. The aim of this 20-year prospective study was to investigate arterial vasopressin, aldosterone, and renin as long-term predictors of LV mass. Normotensives (n=17), subjects who developed hypertension (n=17), and sustained hypertensives (n=22) were compared at baseline (42 years) and at follow-up (62 years). There were no significant differences in baseline vasopressin, aldosterone, or renin levels. The group with sustained hypertension had more LV hypertrophy (P=.025) at follow-up. Among new hypertensives, multiple regression analysis demonstrated that baseline arterial vasopressin (beta-0.53; P=.041) and aldosterone (beta-0.56;P=.032) independently explained LV mass index (R(2)=0.85; P=.035). In conclusion, baseline arterial vasopressin and aldosterone, but not renin, appear to predict LV mass in middle-aged men who developed hypertension over a 20-year period.
authors.affiliation: Department of Cardiology, Ullevaal University Hospital, Oslo, Norway. a.h.strand@medisin.uio.no
authors.forename: Arne H
authors.initials: AH
authors.lastname: Strand
authors.forename: Helga
authors.initials: H
authors.lastname: Gudmundsdottir
authors.forename: Eigil
authors.initials: E
authors.lastname: Fossum
authors.forename: Ingrid
authors.initials: I
authors.lastname: Os
authors.forename: Reidar
authors.initials: R
authors.lastname: Bjørnerheim
authors.forename: Sverre E
authors.initials: SE
authors.lastname: Kjeldsen
mesh_terms: D000328:Adult; D000450:Aldosterone / Q000097:blood*; D000704:Analysis of Variance; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001158:Arteries; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure / Q000187:drug effects; D003430:Cross-Sectional Studies; D004452:Echocardiography; D005500:Follow-Up Studies; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology; D017379:Hypertrophy, Left Ventricular / Q000097:blood* / Q000150:complications* / Q000000981:diagnostic imaging / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012044:Regression Analysis; D012083:Renin / Q000097:blood / Q000187:drug effects; D013997:Time Factors; D014667:Vasopressins / Q000097:blood* / Q000187:drug effects
chemical_list: D000959:Antihypertensive Agents; D015415:Biomarkers; D014667:Vasopressins; D000450:Aldosterone; D012083:Renin