B-cell neurolymphomatosis confined to the peripheral nervous system.
Patients with neurolymphomatosis show lymphoma cells within the peripheral nerves, nerve root/plexus, or cranial nerves. However, most neurolymphomatosis patients show lymphomatous infiltration not only in the peripheral nervous system (PNS), but also in the meninges, Virchow-Robin space, and brain parenchyma. Here, we report a 74-year-old woman with diffuse large B-cell lymphoma presenting with motor-sensory-autonomic polyneuropathy and multiple cranial neuropathies. A diagnosis of neurolymphomatosis was made by sural nerve biopsy. Postmortem examination indicated that lymphoma cell infiltration in the nervous system was confined to the PNS with no involvement of the central nervous system, including the meninges. This was a very rare case of B-cell neurolymphomatosis with lymphomatous infiltration confined to the PNS, suggesting specific affinity of the lymphoma cells for the PNS in this patient.
Shibata-Hamaguchi
Ayumi
A
Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Science, 13-1, Takara-machi, Kanazawa, Ishikawa, 920-8640, Japan. ashibata@med.kanazawa-u.ac.jp
Samuraki
Miharu
M
Furui
Eisuke
E
Ishida
Chiho
C
Kitagawa
Satoshi
S
Nakao
Shinji
S
Minato
Hiroshi
H
Yamada
Masahito
M
D000368:Aged; D001402:B-Lymphocytes / Q000473:pathology; D003389:Cranial Nerve Diseases / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D003391:Cranial Nerves / Q000473:pathology / Q000503:physiopathology; D018450:Disease Progression; D004211:Disseminated Intravascular Coagulation / Q000209:etiology / Q000503:physiopathology; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D016393:Lymphoma, B-Cell / Q000150:complications* / Q000473:pathology* / Q000503:physiopathology; D009361:Neoplasm Invasiveness / Q000473:pathology* / Q000503:physiopathology; D010525:Peripheral Nerves / Q000473:pathology* / Q000503:physiopathology; D010523:Peripheral Nervous System Diseases / Q000209:etiology* / Q000473:pathology* / Q000503:physiopathology; D013126:Spinal Nerve Roots / Q000473:pathology / Q000503:physiopathology