[Pharmacological mechanisms of Doxorubicin activity (DOX) - current state of knowledge].
Doxorubicin (DOX) belongs to the anthracycline antibiotics, widely used in the treatment of various types of malignancies. This review presents recent data about mechanisms of the drug action.
Łubgan
Dorota
D
Katedra Termobiologii, Instytut Biofizyki, Uniwersytet Łódzki.
Marczak
Agnieszka
A
Walczak
Mateusz
M
Distel
Luitpold
L
Jóźwiak
Zofia
Z
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D002467:Cell Nucleus / Q000187:drug effects; D004260:DNA Repair; D004317:Doxorubicin / Q000494:pharmacology*; D006801:Humans; D015394:Molecular Structure; D017382:Reactive Oxygen Species / Q000378:metabolism; D014407:Tumor Cells, Cultured / Q000187:drug effects*
D000903:Antibiotics, Antineoplastic; D017382:Reactive Oxygen Species; D004317:Doxorubicin