title: Anger experiences among hepatitis C patients: relationship to depressive symptoms and health-related quality of life.
abstract: The authors examined anger among hepatitis C (HCV) patients and its relationship to health-related quality of life (HRQL) and depression. Eighty-seven HCV patients who received pegylated interferon-alpha(2b) and ribavirin were included. Patients' mean age was 48 years; 42% were women, and 60% were white. Patients experienced moderate anger while undergoing HCV treatment. Angry feelings increased during treatment in some domains, specifically, Control Over Anger and Angry Reaction. Greater anger was associated with more depression and poorer HRQL. Findings point to the importance for physicians to screen for a wide range of neuropsychiatric side effects of interferon, including anger.
authors.affiliation: Center for Liver Diseases, DepT. of Psychiatry, Inova Fairfax Hospital, Annandale, VA 22003-6800, USA.
authors.forename: Amy A
authors.initials: AA
authors.lastname: Dan
authors.forename: Cathy
authors.initials: C
authors.lastname: Crone
authors.forename: Thomas N
authors.initials: TN
authors.lastname: Wise
authors.forename: Lisa M
authors.initials: LM
authors.lastname: Martin
authors.forename: Lolita
authors.initials: L
authors.lastname: Ramsey
authors.forename: Scarlett
authors.initials: S
authors.lastname: Magee
authors.forename: Robert
authors.initials: R
authors.lastname: Sjogren
authors.forename: Janus P
authors.initials: JP
authors.lastname: Ong
authors.forename: Zobair M
authors.initials: ZM
authors.lastname: Younossi
mesh_terms: D000328:Adult; D000368:Aged; D000786:Anger / Q000187:drug effects*; D000998:Antiviral Agents / Q000008:administration & dosage / Q000009:adverse effects; D015331:Cohort Studies; D003866:Depressive Disorder / Q000139:chemically induced / Q000175:diagnosis / Q000523:psychology*; D005260:Female; D006304:Health Status; D006526:Hepatitis C / Q000188:drug therapy / Q000523:psychology*; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000008:administration & dosage / Q000009:adverse effects; D007389:Internal-External Control; D008297:Male; D008875:Middle Aged; D011092:Polyethylene Glycols; D011237:Predictive Value of Tests; D011788:Quality of Life / Q000523:psychology*; D011994:Recombinant Proteins; D012254:Ribavirin / Q000008:administration & dosage; D011795:Surveys and Questionnaires; D013997:Time Factors
chemical_list: D000998:Antiviral Agents; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D011092:Polyethylene Glycols; D012254:Ribavirin; C417083:peginterferon alfa-2b