title: Automated Improvement of Domain ANnotations using context analysis of domain arrangements (AIDAN).
abstract: BACKGROUND
  Since protein domains are the units of evolution, databases of domain signatures such as ProDom or Pfam enable both a sensitive and selective sequence analysis. However, manually curated databases have a low coverage and automatically generated ones often miss relationships which have not yet been discovered between domains or cannot display similarities between domains which have drifted apart.
  
  
  METHODS
  We present a tool which makes use of the fact that overall domain arrangements are often conserved. AIDAN (Automated Improvement of Domain ANnotations) identifies potential annotation artifacts and domains which have drifted apart. The underlying database supplements ProDom and is interfaced by a graphical tool allowing the localization of single domain deletions or annotations which have been falsely made by the automated procedure.
  
  
  BACKGROUND
  http://www.uni-muenster.de/Evolution/ebb/Services/AIDAN.
  
  
  BACKGROUND
  Supplementary data are available at Bioinformatics online.
authors.affiliation: Evolutionary Bioinformatics, Institute for Evolution and Biodiversity, Westfälische Wilhelms University, Schlossplatz 4, D48149 Münster, Germany.
authors.forename: Francois
authors.initials: F
authors.lastname: Beaussart
authors.forename: January
authors.initials: J
authors.lastname: Weiner
authors.forename: Erich
authors.initials: E
authors.lastname: Bornberg-Bauer
mesh_terms: D000465:Algorithms; D001331:Automation; D016000:Cluster Analysis; D019295:Computational Biology / Q000379:methods*; D016208:Databases, Factual; D016247:Information Storage and Retrieval; D020407:Internet; D011487:Protein Conformation; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000737:chemistry*; D016415:Sequence Alignment; D012984:Software; D014584:User-Computer Interface
chemical_list: D011506:Proteins