title: Protective effect of collagen derivates on the ulcerative lesions caused by oral administration of ethanol.
abstract: The protective effect of beef and pig collagen hydrolysates and their fractions were tested as anti-ulcerogenic agents in rats (weighing 250-350 g) against ulcerative lesions caused by ethanol. Beef and pig collagen hydrolysates were fractionated by ultrafiltration into different molecular weight fractions. The protocol employed a negative and a positive control and a single dose of the experimental samples given by intragastric intubation. The beef collagen did not present a dose-response correlation in the ethanol model, whereas pig collagen showed a logarithmic dose-response relationship. Beef collagen hydrolysate decreased the ulcerative lesion index of 55% versus a 61% decrease for pig collagen hydrolysate at the same dosage (750 mg/kg of body weight). No significant differences were found (P > .05) between the hydrolysates and their fractions.
authors.affiliation: Departamento de Alimentos e Nutrição, Faculdade de Engenharia de Alimentos, Universidade Estadual de Campinas, Campinas, São Paulo, Brasil.
authors.forename: G A
authors.initials: GA
authors.lastname: Castro
authors.forename: V C
authors.initials: VC
authors.lastname: Sgarbieri
authors.forename: J E
authors.initials: JE
authors.lastname: Carvalho
authors.forename: S V
authors.initials: SV
authors.lastname: Tinti
authors.forename: A
authors.initials: A
authors.lastname: Possenti
mesh_terms: D000818:Animals; D000897:Anti-Ulcer Agents / Q000008:administration & dosage; D002229:Carbenoxolone / Q000008:administration & dosage; D002417:Cattle; D003094:Collagen / Q000008:administration & dosage* / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000633:toxicity*; D006868:Hydrolysis; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D013552:Swine
chemical_list: D000897:Anti-Ulcer Agents; D000431:Ethanol; D003094:Collagen; D002229:Carbenoxolone