Dendritic cells and skin sensitization: biological roles and uses in hazard identification.
Recent advances have been made in our understanding of the roles played by cutaneous dendritic cells (DCs) in the induction of contact allergy. A number of associated changes in epidermal Langerhans cell phenotype and function required for effective skin sensitization are providing the foundations for the development of cellular assays (using DC and DC-like cells) for skin sensitization hazard identification. These alternative approaches to the identification and characterization of skin sensitizing chemicals were the focus of a Workshop entitled "Dendritic Cells and Skin Sensitization: Biological Roles and Uses in Hazard Identification" that was given at the annual Society of Toxicology meeting held March 6-9, 2006 in San Diego, California. This paper reports information that was presented during the Workshop.
Ryan
Cindy A
CA
The Procter and Gamble Company, Miami Valley Innovation Center, Cincinnati, OH 45253-8707, USA.
Kimber
Ian
I
Basketter
David A
DA
Pallardy
Marc
M
Gildea
Lucy A
LA
Gerberick
G Frank
GF
D000485:Allergens / Q000276:immunology*; D000818:Animals; D003713:Dendritic Cells / Q000276:immunology*; D003877:Dermatitis, Contact / Q000276:immunology*; D000078404:Epidermal Cells; D004817:Epidermis / Q000276:immunology; D006801:Humans; D007114:Immunization / Q000379:methods; D007801:Langerhans Cells / Q000166:cytology / Q000276:immunology*; D018570:Risk Assessment; D012882:Skin Tests / Q000379:methods*
D000485:Allergens