Genomic imprinting - the story of the other half and the conflicts of silencing.
Genomic imprinting is an epigenetic mechanism that produces functional differences between the paternal and maternal genomes and plays an essential role in mammalian development and growth. There are a number of genes in our genomes that are subject to genomic imprinting where one parent's copy of the gene is expressed while the other is silent. Silencing of one allele predetermines that any function ascribed to that gene are now dependant on the single active copy. Possession of only a single active allele can lead to deleterious health consequences in humans. If imprinted genes are crucial in mammalian development, one would also expect mutations in these genes to cause diseases. Since imprinting is an epigenetic mechanism, mistakes in maintaining epigenetic mark also cause imprinting disorders. Here we in this review focus on the current understanding of this unique genetic mechanism more than two decades after the first description of the imprinting phenomenon was given by McGrath and Solter. Although the possible molecular mechanisms by which imprinting is imposed and maintained are being identified, we have a long way to go in understanding the molecular mechanisms that regulate the expression of these oddly behaving genes, the function of imprinting and the evolution. Post genomic technologies might ultimately lead to a better understanding of the 'imprinting effects'.
Munshi
Anjana
A
Department of Genetics, Shadan PG Centre for Biosciences, Khairtabad Hyderabad 500016, India. durani65@yahoo.co.in
Duvvuri
Shanti
S
D000818:Animals; D044127:Epigenesis, Genetic / Q000502:physiology*; D005260:Female; D020868:Gene Silencing / Q000941:ethics / Q000502:physiology*; D018392:Genomic Imprinting / Q000235:genetics*; D006801:Humans; D011247:Pregnancy