title: Pharmacokinetics of antifungal agent micafungin in critically ill patients receiving continuous hemodialysis filtration.
abstract: Currently in Japan, the preferred method for blood purification in patients with acute renal failure is continuous hemodiafiltration (CHDF). However, CHDF filters out various antifungal drugs such as fluconazole through large pores in the membrane used. Systemic fungal infection is still one of the main causes of death and complications in critically ill patients in intensive care units (ICUs). Therefore it is important to determine the appropriate use of antifungal agents. This study was designed to evaluate the influence of CHDF on the pharmacokinetics of the antifungal agent micafungin in ICU patients. The pharmacokinetics of micafungin were studied in four ICU patients receiving CHDF and in nine ICU patients not receiving CHDF. To evaluate the pharmacokinetics, the ratio of serum micafungin concentration to dose per body weight (C/D) was used in this study. There was no progressive accumulation or exclusion of micafungin in patients receiving CHDF. The mean (+/-S.D.) extraction rate (%) for micafungin during CHDF was 3.6+/-3.9. There was no significant difference in the serum micafungin C/D-time profiles between the patients receiving and not receiving CHDF. These results show that CHDF does not affect the pharmacokinetics of micafungin. Therefore it is not necessary to adjust the micafungin dose in patients receiving CHDF.
authors.affiliation: Department of Pharmacy, Nippon Medical School Hospital, Tokyo, Japan. k-hi@nms.ac.jp
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Hirata
authors.forename: Takahiko
authors.initials: T
authors.lastname: Aoyama
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Matsumoto
authors.forename: Futosi
authors.initials: F
authors.lastname: Ogawa
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yamazaki
authors.forename: Arimichi
authors.initials: A
authors.lastname: Kikuti
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Yamamoto
mesh_terms: D058186:Acute Kidney Injury / Q000378:metabolism*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000935:Antifungal Agents / Q000493:pharmacokinetics*; D016638:Critical Illness; D054714:Echinocandins; D017583:Hemodiafiltration; D006801:Humans; D007362:Intensive Care Units; D055666:Lipopeptides; D008074:Lipoproteins / Q000493:pharmacokinetics*; D008297:Male; D000077551:Micafungin; D008875:Middle Aged; D010456:Peptides, Cyclic / Q000493:pharmacokinetics*
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D008074:Lipoproteins; D010456:Peptides, Cyclic; D000077551:Micafungin