title: Free tissue transfer to manage salvage laryngectomy defects after organ preservation failure.
abstract: OBJECTIVE
  Salvage laryngectomy to treat organ preservation failures results in significantly higher local wound complications. Even in the absence of extralaryngeal disease, primary closure of laryngeal defects can result in protracted wound care problems. We hypothesize that even when sufficient mucosa is present to close the defect primarily, introduction of vascularized tissue to close the defect may improve outcomes.
  
  
  METHODS
  Retrospective case-control study.
  
  
  METHODS
  Two academic tertiary care centers.
  
  
  METHODS
  Patients undergoing salvage surgery for laryngeal squamous cell carcinoma between 2000 to 2006 were considered for this study. Patients requiring total laryngopharyngectomy or partial pharyngectomy were excluded. There were 37 patients who met study criteria: 17 patients underwent free flap reconstruction (16 radial forearm flaps and 1 rectus flap), and 20 patients underwent primary closure. The median follow-up was 12 (range, 4-60) months. Previous treatment consisted of chemoradiation for 41% of the reconstruction group and 35% of the primary closure group; the remainder were treated with primary radiation alone.
  
  
  METHODS
  Pharyngocutaneous fistula, stricture, length of hospitalization, feeding tube dependence.
  
  
  RESULTS
  The free flap reconstruction group had a lower rate of fistula (18%) compared with the primary closure group (50%). A lower rate of stricture formation (18% vs. 25%) and feeding tube dependence (23% vs. 45%) was observed in the free flap reconstruction group compared with the primary closure group. The development of a fistula in either group resulted in a prolonged hospital stay (mean, 19 vs. 7 days) and additional procedures.
  
  
  CONCLUSIONS
  Planned reconstruction of salvage laryngectomy defects with vascularized tissue is associated with a lower fistula rate and may improve outcomes.
authors.affiliation: Department of Surgery, Division of Otolaryngology-Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama 35294-0012, USA.
authors.forename: Kirk P
authors.initials: KP
authors.lastname: Withrow
authors.forename: Eben L
authors.initials: EL
authors.lastname: Rosenthal
authors.forename: Christine G
authors.initials: CG
authors.lastname: Gourin
authors.forename: Glenn E
authors.initials: GE
authors.lastname: Peters
authors.forename: J Scott
authors.initials: JS
authors.lastname: Magnuson
authors.forename: David J
authors.initials: DJ
authors.lastname: Terris
authors.forename: William W
authors.initials: WW
authors.lastname: Carroll
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery*; D016022:Case-Control Studies; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery*; D007825:Laryngectomy; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000453:epidemiology*; D019651:Plastic Surgery Procedures; D012189:Retrospective Studies; D016879:Salvage Therapy; D013524:Surgical Flaps; D016896:Treatment Outcome