title: The effect of Bacillus Calmette-Guerin in a mouse model of allergic rhinitis.
abstract: OBJECTIVE
  To develop an allergic rhinitis model via local sensitization of mice with Dermatophagoides pteronyssinus and to use the model to investigate the antiallergic effect of Bacillus Calmette-Guerin (BCG).
  
  
  METHODS
  BALB/c mice were randomized to the allergic rhinitis group, the BCG group sensitized with D pteronyssinus via local sensitization for 7 weeks, or the control group. The BCG group received 1 x 10(5) colony-forming unit/mL of BCG seven times. We evaluated symptoms, nasal mucosa eosinophilia, serum total IgE, cytokines, and eosinophilia in bronchoalveolar lavage fluid.
  
  
  RESULTS
  In the allergic rhinitis group, allergy symptoms (P < 0.001), eosinophil count (P < 0.001), total IgE (P < 0.001), inflammatory cells (P < 0.01), and IL-13 (P = 0.046) increased and interferon gamma (IFN-gamma) (P < 0.001) decreased compared with the control group. In the BCG group, allergy symptoms (P < 0.001), eosinophil count (P < 0.001), and inflammatory cells (P < 0.01) decreased and IFN-gamma (P = 0.031) increased compared with the allergic rhinitis group.
  
  
  CONCLUSIONS
  In an allergic rhinitis animal model developed via local sensitization of mice with D pteronyssinus, BCG was shown to exhibit an antiallergic effect.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
authors.forename: Soo Whan
authors.initials: SW
authors.lastname: Kim
authors.forename: Sang Won
authors.initials: SW
authors.lastname: Yeo
mesh_terms: D000818:Animals; D001500:BCG Vaccine / Q000008:administration & dosage* / Q000494:pharmacology*; D018893:Bronchoalveolar Lavage; D040001:Dermatophagoides farinae / Q000187:drug effects / Q000276:immunology; D040002:Dermatophagoides pteronyssinus / Q000187:drug effects / Q000276:immunology; D004195:Disease Models, Animal; D004804:Eosinophils / Q000378:metabolism; D007073:Immunoglobulin E / Q000097:blood / Q000187:drug effects*; D007371:Interferon-gamma / Q000187:drug effects*; D008214:Lymphocytes / Q000187:drug effects; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D008807:Mice, Inbred BALB C; D009297:Nasal Mucosa / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D009504:Neutrophils / Q000187:drug effects; D011897:Random Allocation; D006255:Rhinitis, Allergic, Seasonal / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D018709:Statistics, Nonparametric
chemical_list: D001500:BCG Vaccine; D007073:Immunoglobulin E; D007371:Interferon-gamma