title: Radiotherapy for localised and advanced Merkel cell carcinoma of the skin: a single institution case series.
abstract: Merkel cell carcinoma (MCC) is a rare malignant tumour of the skin with a tendency to rapid local progression, frequent spread to regional lymph nodes and distant metastases. We report results with radiotherapy in the treatment of MCC.Thirty-nine patients with histologically proven MCC were treated. Fifteen patients had stage I disease (12 primary, 3 recurrent tumours). Twenty-one patients had stage II disease (10 primary, 11 recurrent tumours). Thirty patients were treated with surgery and adjuvant radiotherapy. Six patients with inoperable disease received radiotherapy alone. Three patients in stage III with distant metastases were treated with palliative radiotherapy. For stage I patients, 3-year loco-regional control (LC), disease-specific survival (DSS) and overall survival (OS) rates were 90%, 100%, and 100%, respectively. For stage II patients, LC, DSS, and OS were 78%, 55%, and 29%, respectively. LC did not differ significantly between stage I and II patients. But, patients presented to radiotherapy directly after operation showed significantly improved LC compared to patients referred in recurrent situation (p = 0.039). Two of six inoperable patients treated with radiotherapy alone relapsed locally. In the current study, surgery and immediate adjuvant radiotherapy resulted in strong loco-regional control. Radiotherapy alone is suggested only in inoperable or metastatic MCC.
authors.affiliation: Department of Radiooncology, University of Heidelberg, Im Neuenheimer Feld 400, Heidelberg, Germany.
authors.forename: Falk
authors.initials: F
authors.lastname: Roeder
authors.forename: Robert
authors.initials: R
authors.lastname: Krempien
authors.forename: Florian
authors.initials: F
authors.lastname: Sterzing
authors.forename: Angela
authors.initials: A
authors.lastname: Funk
authors.forename: Martina
authors.initials: M
authors.lastname: Treiber
authors.forename: Jürgen
authors.initials: J
authors.lastname: Debus
authors.forename: Marc
authors.initials: M
authors.lastname: Bischof
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015266:Carcinoma, Merkel Cell / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008207:Lymphatic Metastasis / Q000532:radiotherapy; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis / Q000532:radiotherapy; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control; D009367:Neoplasm Staging; D010166:Palliative Care; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies; D012878:Skin Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D016896:Treatment Outcome