Elevated cerebrospinal fluid neurofilament light protein concentrations predict the development of AIDS dementia complex.
The light subunit of neurofilament protein (NFL) is a sensitive indicator of central nervous system axonal injury. We retrospectively identified 9 subjects participating in a longitudinal cohort study who developed acquired immunodeficiency syndrome dementia complex (ADC) and who had had a lumbar puncture performed within 2 years before presentation. Elevated cerebrospinal fluid (CSF) NFL concentrations were found in 7 (78%) of the 9 case patients who later developed ADC, compared with 9 (33%) of 27 CD4 cell count-matched HIV-1-infected control subjects. By contrast, no differences were found in CSF HIV-1 RNA or neopterin concentrations between the 2 groups. CSF NFL may prove to be a useful predictive marker for ADC.
Gisslen
Magnus
M
Department of Infectious Diseases, The Sahlgrenska Academy at Goteborg University, Goteborg, SE-416 85, Sweden, and Department of Neurology, St. Vincent's Hospital, Sydney, NSW, Australia. magnus.gisslen@infect.gu.se
Hagberg
Lars
L
Brew
Bruce J
BJ
Cinque
Paola
P
Price
Richard W
RW
Rosengren
Lars
L
D015526:AIDS Dementia Complex / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology*; D015415:Biomarkers / Q000134:cerebrospinal fluid; D015331:Cohort Studies; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000503:physiopathology; D015497:HIV-1 / Q000235:genetics; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D019798:Neopterin / Q000134:cerebrospinal fluid; D016900:Neurofilament Proteins / Q000134:cerebrospinal fluid*; D011237:Predictive Value of Tests; D012367:RNA, Viral / Q000097:blood / Q000134:cerebrospinal fluid; D012189:Retrospective Studies; D013997:Time Factors
D015415:Biomarkers; D016900:Neurofilament Proteins; D012367:RNA, Viral; C044882:neurofilament protein L; D019798:Neopterin