title: Importance of interaction between C1 domain and lipids in protein kinase C alpha activation: hydrophobic side chain direction in isobenzofuranone ligands controls enzyme activation level.
authors.affiliation: Synthetic Organic Chemistry Laboratory, RIKEN, 2-1, Hirosawa, Wako-shi, Saitama 351-0198, Japan.
authors.forename: Go
authors.initials: G
authors.lastname: Hirai
authors.forename: Tadashi
authors.initials: T
authors.lastname: Shimizu
authors.forename: Toru
authors.initials: T
authors.lastname: Watanabe
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Ogoshi
authors.forename: Megumi
authors.initials: M
authors.lastname: Ohkubo
authors.forename: Mikiko
authors.initials: M
authors.lastname: Sodeoka
mesh_terms: D004789:Enzyme Activation; D005663:Furans / Q000737:chemistry / Q000378:metabolism*; D006860:Hydrogen Bonding; D008024:Ligands; D008958:Models, Molecular; D051571:Protein Kinase C-alpha / Q000378:metabolism*; D013329:Structure-Activity Relationship
chemical_list: D005663:Furans; D008024:Ligands; D051571:Protein Kinase C-alpha