title: Behavioural effects of rapid intravenous administration of meta-chlorophenylpiperazine (m-CPP) in patients with generalized social anxiety disorder, panic disorder and healthy controls.
abstract: Findings from epidemiological, pharmacotherapeutical, genetic and neurobiological studies suggest a possible overlap in the neurobiology of generalized social anxiety disorder (gSAD) and panic disorder (PD). Previously we have found a rapid intravenous m-CPP challenge of 0.1 mg/kg to be highly sensitive and selective in the provocation of panic attacks in patients with PD. We therefore directly compared the behavioural, neuroendocrine and physiological effects of this rapid m-CPP challenge in a small sample of patients with gSAD, patients with PD and matched healthy controls. Panic attacks were significantly more provoked in patients with PD (85%), but not in patients with gSAD (14%) as compared to healthy controls (0%). Effects on the other behavioural parameters, but not on the neuroendocrine and physiological parameters, were significantly greater in patients with PD compared to patients with gSAD and controls. Our preliminary data do not support a shared neurobiology of gSAD and PD.
authors.affiliation: Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands. j.f.van_veen@lumc.nl
authors.forename: J F
authors.initials: JF
authors.lastname: Van Veen
authors.forename: N J A
authors.initials: NJ
authors.lastname: Van der Wee
authors.forename: J
authors.initials: J
authors.lastname: Fiselier
authors.forename: I M
authors.initials: IM
authors.lastname: Van Vliet
authors.forename: H G M
authors.initials: HG
authors.lastname: Westenberg
mesh_terms: D000328:Adult; D001008:Anxiety Disorders / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D005260:Female; D013006:Growth Hormone / Q000378:metabolism*; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism*; D007275:Injections, Intravenous / Q000379:methods; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement / Q000187:drug effects*; D016584:Panic Disorder / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D010879:Piperazines / Q000008:administration & dosage*; D017366:Serotonin Receptor Agonists / Q000008:administration & dosage*; D016037:Single-Blind Method; D018709:Statistics, Nonparametric; D013997:Time Factors
chemical_list: D010879:Piperazines; D017366:Serotonin Receptor Agonists; D013006:Growth Hormone; C015068:1-(3-chlorophenyl)piperazine; D006854:Hydrocortisone