Expression of monocyte chemoattractant protein-1 in idiopathic dilated cardiomyopathy.
Immunological factors have been involved in the pathogenesis of dilated cardiomyopathy (DCM). The cytotoxic action of macrophages is one of the main factors causing cardiac myocyte damage. Monocyte chemoattractant protein-1 (MCP-1) is a major signal for the accumulation of monocytes/macrophages. We examined whether MCP-1 was expressed in the myocardium of DCM patients and whether the expression level was correlated with the degree of impairment of cardiac function. The expression of MCP-1 in the myocardium was determined by immunohistochemistry in endomyocardial biopsy samples from 13 patients. The expression of MCP-1 was found in all myocardial samples from DCM patients but not in those from control subjects. Positive staining for MCP-1 was distinct in cardiac myocytes, interstitium and infiltrating cells. Semi-quantitative analysis revealed that the expression of MCP-1 was inversely correlated with left ventricular ejection fraction. In conclusion, the expression level of MCP-1 in the myocardium was correlated with the degree of impairment of cardiac function in patients with DCM.
Kobayashi
Makoto
M
Nakamura
Kazufumi
K
Kusano
Kengo Fukushima
KF
Nakamura
Yoichi
Y
Ohta-Ogo
Keiko
K
Nagase
Satoshi
S
Sakuragi
Satoru
S
Ohe
Tohru
T
D000328:Adult; D015415:Biomarkers / Q000032:analysis; D001707:Biopsy, Needle; D002311:Cardiomyopathy, Dilated / Q000401:mortality* / Q000473:pathology* / Q000503:physiopathology; D016022:Case-Control Studies; D018932:Chemokine CCL2 / Q000097:blood / Q000378:metabolism*; D018450:Disease Progression; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005500:Follow-Up Studies; D006334:Heart Function Tests; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D011336:Probability; D012333:RNA, Messenger / Q000032:analysis; D012016:Reference Values; D012189:Retrospective Studies; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D015996:Survival Rate
D015415:Biomarkers; D018932:Chemokine CCL2; D012333:RNA, Messenger