title: Getting connected: analysis and principles of biological networks.
abstract: The execution of complex biological processes requires the precise interaction and regulation of thousands of molecules. Systematic approaches to study large numbers of proteins, metabolites, and their modification have revealed complex molecular networks. These biological networks are significantly different from random networks and often exhibit ubiquitous properties in terms of their structure and organization. Analyzing these networks provides novel insights in understanding basic mechanisms controlling normal cellular processes and disease pathologies.
authors.affiliation: Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut 06520, USA.
authors.forename: Xiaowei
authors.initials: X
authors.lastname: Zhu
authors.forename: Mark
authors.initials: M
authors.lastname: Gerstein
authors.forename: Michael
authors.initials: M
authors.lastname: Snyder
mesh_terms: D000818:Animals; D004194:Disease / Q000209:etiology; D019143:Evolution, Molecular; D006801:Humans; D008954:Models, Biological; D008957:Models, Genetic; D009154:Mutation; D010766:Phosphorylation; D025941:Protein Interaction Mapping; D011506:Proteins / Q000378:metabolism; D049490:Systems Biology; D014157:Transcription Factors / Q000378:metabolism
chemical_list: D011506:Proteins; D014157:Transcription Factors