title: [A case of primary malignant lymphoma of thyroid in young man].
abstract: The aim of this study is to present a case of a 36-year old male with a rare thyroid malignancy--a primary thyroid lymphoma. The patient was admitted to the Department of Endocrinology due to a rapidly enlarging left-sided tumor of the neck and hoarseness lasting for 2 weeks. The only abnormality found on biochemical testing was a slightly elevated titre of anti-TPO antibodies. On X-ray examination, both a compression and deviation of the trachea was found. Ultrasound examination of the neck revealed a left-sided thyroid lesion and fine needle aspiration (FNA) was performed under ultrasound guidance. A monotonous population of mid-size lymphoid cells was found with negative immunocytochemistry for thyroglobuline and CD 68. After hematological and pathological evaluation the FNA report was considered as non-diagnostic. Taking into consideration the presence of rapidly occurring compressive symptoms caused by a tumor of unknown cytological origin, the patient was referred to urgent thyroid surgery. Pathological report of postoperative specimen allowed for the final diagnosis of a malignant lymphoma originating from non-Hodgkin B cells of the thyroid gland; diffuse large B-cell lymphoma (DLCL) according to WHO classification. L-thyroxin substitution therapy, chemo- and radiotherapy were used after the operation. The described case of a very rare type of primary thyroid malignancy illustrates difficulties which can be encountered in diagnostic approach and therapeutic decision making in patients with rapidly enlarging thyroid tumors.
authors.affiliation: Katedra i Klinika Endokrynologii, Collegium Medicum Uniwersytetu Jagiellońskiego w Krakowie. filgol@cm-uj.krakow.pl
authors.forename: Filip
authors.initials: F
authors.lastname: Gołkowski
authors.forename: Monika
authors.initials: M
authors.lastname: Buziak-Bereza
authors.forename: Marcin
authors.initials: M
authors.lastname: Barczyński
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Stefańska
authors.forename: Wojciech
authors.initials: W
authors.lastname: Wierzchowski
authors.forename: Bohdan
authors.initials: B
authors.lastname: Huszno
authors.forename: Stanisław
authors.initials: S
authors.lastname: Cichoń
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D044963:Biopsy, Fine-Needle; D017024:Chemotherapy, Adjuvant; D003520:Cyclophosphamide / Q000627:therapeutic use; D004317:Doxorubicin / Q000627:therapeutic use; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis* / Q000188:drug therapy / Q000601:surgery*; D008297:Male; D011241:Prednisone / Q000627:therapeutic use; D012074:Remission Induction; D013961:Thyroid Gland / Q000000981:diagnostic imaging / Q000473:pathology; D013964:Thyroid Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000601:surgery*; D013965:Thyroidectomy; D013974:Thyroxine / Q000627:therapeutic use; D014463:Ultrasonography; D014750:Vincristine / Q000627:therapeutic use
chemical_list: D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D013974:Thyroxine; D011241:Prednisone