Influence of metabolic risk factors on the presence of carotid artery disease in patients with type 2 diabetes and coronary artery disease.
The aim of the study was to evaluate the prevalence of carotid artery disease in type 2 diabetes patients with coronary artery disease, and to establish the influence of metabolic factors on its occurrence. In all, 145 patients (aged 59.85+/-8.43 years, diabetes duration 8.89+/-6.29 years) were randomly selected in a cross-sectional study. Carotid ultrasound was used for evaluation of the presence of carotid plaque (CP) and stenosis (CS). A logistic regression model was constructed to define the influence of risk factors-- arterial hypertension, systolic blood pressure, weight, waist to hip ratio, high blood glucose and plasma lipid levels. Carotid artery disease was present in these patients with a prevalence of 81.9% for CP, 25.2% for unilateral CS and 13.5% for bilateral CS. The low-density lipoprotein (LDL) cholesterol level was an independent predictor for CS (OR 1.936; 95% CI 1.2413.026). Non-high density lipoprotein (HDL) cholesterol (OR 1.374; 95% CI 1.0351.825) and glycaemia (OR 1.214; 95% CI 1.0221.442) were predictors for carotid plaque.
Bosevski
Marijan
M
Institute for Heart Disease, Medical School Skopje, Skopje, Macedonia. marijanbosevski@yahoo.com
Borozanov
Vladimir
V
Georgievska-Ismail
Ljubica
L
D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure; D002340:Carotid Artery Diseases / Q000453:epidemiology / Q000209:etiology*; D003324:Coronary Artery Disease / Q000150:complications*; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000503:physiopathology; D003925:Diabetic Angiopathies / Q000453:epidemiology*; D005260:Female; D006801:Humans; D050356:Lipid Metabolism; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors
D001786:Blood Glucose