Domain-specific impairment of source memory following a right posterior medial temporal lobe lesion.
This single case analysis of memory performance in a patient with an ischemic lesion affecting posterior but not anterior right medial temporal lobe (MTL) indicates that source memory can be disrupted in a domain-specific manner. The patient showed normal recognition memory for gray-scale photos of objects (visual condition) and spoken words (auditory condition). While memory for visual source (texture/color of the background against which pictures appeared) was within the normal range, auditory source memory (male/female speaker voice) was at chance level, a performance pattern significantly different from the control group. This dissociation is consistent with recent fMRI evidence of anterior/posterior MTL dissociations depending upon the nature of source information (visual texture/color vs. auditory speaker voice). The findings are in good agreement with the view of dissociable memory processing by the perirhinal cortex (anterior MTL) and parahippocampal cortex (posterior MTL), depending upon the neocortical input that these regions receive.
Peters
Jan
J
International Graduate School of Neuroscience, Ruhr-University of Bochum, Germany. jan.peters1@gmail.com
Koch
Benno
B
Schwarz
Michael
M
Daum
Irene
I
D000161:Acoustic Stimulation; D000328:Adult; D001307:Auditory Perception; D018728:Entorhinal Cortex / Q000473:pathology / Q000503:physiopathology; D005260:Female; D007839:Functional Laterality; D006624:Hippocampus / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D020762:Infarction, Posterior Cerebral Artery / Q000150:complications / Q000473:pathology / Q000503:physiopathology; D008279:Magnetic Resonance Imaging; D008568:Memory; D008569:Memory Disorders / Q000209:etiology / Q000473:pathology* / Q000503:physiopathology*; D009434:Neural Pathways / Q000473:pathology / Q000503:physiopathology; D009483:Neuropsychological Tests; D020534:Parahippocampal Gyrus / Q000473:pathology / Q000503:physiopathology; D010775:Photic Stimulation; D013702:Temporal Lobe / Q000473:pathology* / Q000503:physiopathology*; D014796:Visual Perception