[Diabetic neuropathy].
Diabetic neuropathy is most common chronic complication of diabetes mellitus. It is responsible for substantial morbidity, increased mortality and impaired quality of life. Patogenesis of diabetic neuropathy is complex. Chronic hyperglycemia is a major factor induces nerve fibers injury. High level of glucose stimulate the polyol pathway causing osmotic stress and enhance reactive oxygen species generation, as well as it play an important role in diabetic angiopathy development. Distal symmetric polineuropathy is most common type of diabetic neuropathy. Many patient may develop combinations of neuropathies concerning somatic and autonomic system. Early diagnosis and administered suitable treatment are necessary to reduce severe complication of diabetic neuropathy as well as strict glycemic control and risk factor increased.
Chudzik
Wiesław
W
Departament of Neurology and Neurorehabilitation with Stroke Unit, Clinical Hospital in Lódź, Poland.
Kaczorowska
Beata
B
Przybyła
Monika
M
Chudzik
Bartosz
B
Gałka
Małgorzata
M
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003920:Diabetes Mellitus / Q000175:diagnosis* / Q000453:epidemiology / Q000473:pathology / Q000503:physiopathology*; D003925:Diabetic Angiopathies / Q000175:diagnosis / Q000503:physiopathology; D017719:Diabetic Foot / Q000175:diagnosis / Q000503:physiopathology; D003929:Diabetic Neuropathies / Q000473:pathology / Q000503:physiopathology* / Q000517:prevention & control*; D018149:Glucose Intolerance / Q000175:diagnosis / Q000503:physiopathology; D006801:Humans; D006943:Hyperglycemia / Q000175:diagnosis / Q000503:physiopathology*; D007328:Insulin / Q000172:deficiency; D010525:Peripheral Nerves / Q000098:blood supply / Q000378:metabolism
D001786:Blood Glucose; D007328:Insulin