title: Effect of Baohuoside-1 aglycone and tacrolimus monotherapy and combination therapy on prevention of acute heart allograft rejection in the rat.
abstract: Baohuoside-1 (B-1), a recently introduced novel immunosuppressant that was proved to be potent in inhibition of T and B cell proliferation and B-1, also prevents cardiac allograft rejection in rodents. The present study further proved that monotherapy of B-1's analogue B-1 aglycone effectively prolongs cardiac allograft survival and combination therapy of B-1 aglycone with tacrolimus (FK506) produces synergistic effect in prevention acute cardiac allograft rejection in the rat. .
authors.affiliation: Laboratory of Experimental Surgery, Research Center of Centre Hospitalier de l'Université de Montréal, Hôspital Notre-Dame, Montreal, QC, Canada.
authors.forename: Shijie
authors.initials: S
authors.lastname: Qi
authors.forename: Hong
authors.initials: H
authors.lastname: Zhao
authors.forename: Anlun
authors.initials: A
authors.lastname: Ma
authors.forename: Longshan
authors.initials: L
authors.lastname: Liu
authors.forename: Xiang
authors.initials: X
authors.lastname: Wang
authors.forename: Dasheng
authors.initials: D
authors.lastname: Xu
authors.forename: Geng
authors.initials: G
authors.lastname: Lin
authors.forename: Kouichi
authors.initials: K
authors.lastname: Tamura
authors.forename: Hongsi
authors.initials: H
authors.lastname: Jiang
authors.forename: Pierre
authors.initials: P
authors.lastname: Daloze
authors.forename: Huifang
authors.initials: H
authors.lastname: Chen
mesh_terms: D000208:Acute Disease; D000818:Animals; D004359:Drug Therapy, Combination; D005419:Flavonoids / Q000737:chemistry / Q000627:therapeutic use*; D006084:Graft Rejection / Q000517:prevention & control*; D016027:Heart Transplantation / Q000401:mortality*; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008297:Male; D011897:Random Allocation; D051381:Rats; D011914:Rats, Inbred BN; D011917:Rats, Inbred Lew; D015996:Survival Rate; D016559:Tacrolimus / Q000627:therapeutic use*; D014184:Transplantation, Homologous
chemical_list: D005419:Flavonoids; D007166:Immunosuppressive Agents; C060988:baohuoside I; D016559:Tacrolimus