title: Fusidic acid-resistant Staphylococcus aureus (FRSA) carriage in patients with atopic eczema and pattern of prior topical fusidic acid use.
abstract: We questioned 62 dermatology outpatients with atopic eczema and Staphylococcus aureus colonisation regarding their use of topical preparations containing fusidic acid during the previous 6 months as well as the pattern of any such use. Recent exposure to topical fusidic acid was significantly correlated with the presence of fusidic acid-resistant S. aureus (FRSA) (P=0.04). There was also a significant trend towards increasing FRSA carriage with increased duration of use. Short courses of 2 weeks or less did not appear to change the FRSA profile compared with non-exposure, and intermittent usage appeared to be the most detrimental, although subgroup sizes were small. Our study cautions against prolonged or intermittent use of fusidic acid-containing products in patients with eczema.
authors.affiliation: Clinical Microbiology and Public Health Laboratory, Health Protection Agency, Box 236, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QW, UK. jumoke.sule@addenbrookes.nhs.uk
authors.forename: Olajumoke
authors.initials: O
authors.lastname: Sule
authors.forename: Nicholas M
authors.initials: NM
authors.lastname: Brown
authors.forename: Lorna J
authors.initials: LJ
authors.lastname: Willocks
authors.forename: Jane
authors.initials: J
authors.lastname: Day
authors.forename: Sonal
authors.initials: S
authors.lastname: Shankar
authors.forename: Christopher R
authors.initials: CR
authors.lastname: Palmer
authors.forename: Nigel P
authors.initials: NP
authors.lastname: Burrows
mesh_terms: D000287:Administration, Topical; D002353:Carrier State / Q000382:microbiology; D002648:Child; D002675:Child, Preschool; D003876:Dermatitis, Atopic / Q000150:complications / Q000382:microbiology*; D024881:Drug Resistance, Bacterial; D005260:Female; D005672:Fusidic Acid / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use*; D006801:Humans; D007223:Infant; D008297:Male; D008826:Microbial Sensitivity Tests; D013207:Staphylococcal Skin Infections / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000302:isolation & purification
chemical_list: D005672:Fusidic Acid