title: Implication of the new low-density lipoprotein goals in dyslipidemia management of patients with acute coronary syndrome.
abstract: OBJECTIVE
  To assess the ability of patients with an acute coronary syndrome (ACS) to meet the recommended low-density lipoprotein cholesterol (LDL-C) goal of 100 mg/dL and optional aggressive lowering to 70 mg/dL.
  
  
  METHODS
  Patients diagnosed as having ACS who had lipid levels measured within 24 hours of admission from January 1, 1998, through December 31, 2002, were assessed for the ability to meet the 2 target LDL-C levels. Patients were considered to have ACS if they were diagnosed as having myocardial infarction, had significant disease on angiography, or had a history of coronary artery disease. Patients were classified into 1 of 4 groups on the basis of the degree of LDL-C lowering required to meet the 2 different goals: less than 33%, 33% to 39%, 40% to 49%, and 50% or more. Patients with myocardial infarction who had lipid sampling performed more than 24 hours after admission were excluded.
  
  
  RESULTS
  The mean plus-or-minus SD LDL-C level was 111 plus-or-minus 43 mg/dL in the 1322 patients who met criteria for ACS and had LDL-C levels assessed. On the basis of a target LDL-C value of less than 100 mg/dL, 43% of patients were at goal and did not require treatment, and only 2.5% had an LDL-C level that required a 50% or greater reduction to meet goal. In contrast, using the newer LDL-C target of 70 mg/dL, 85% patients required treatment, and 23% of patients required a 50% or greater decrease in LDL-C level and therefore were likely to require more than 1 lipid-lowering agent.
  
  
  CONCLUSIONS
  Decreasing the LDL-C target to less than 70 mg/dL substantially increases the number of patients with ACS who would require treatment. A significant proportion of patients will require a reduction in LDL-C level of 50% or more, which is not easily achievable with current lipid-lowering monotherapy.
authors.affiliation: Department of Internal Medicine, Cardiology Division, Virginia Commonwealth University, Richmond, VA 23298-0051, USA. mckontos@vcu.edu
authors.forename: Michael C
authors.initials: MC
authors.lastname: Kontos
authors.forename: Sarah E
authors.initials: SE
authors.lastname: Joyner
authors.forename: Charlotte S
authors.initials: CS
authors.lastname: Roberts
authors.forename: F Philip
authors.initials: FP
authors.lastname: Anderson
authors.forename: Joseph P
authors.initials: JP
authors.lastname: Ornato
authors.forename: James L
authors.initials: JL
authors.lastname: Tatum
authors.forename: Robert L
authors.initials: RL
authors.lastname: Jesse
mesh_terms: D000368:Aged; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood*; D050171:Dyslipidemias / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood*; D013577:Syndrome
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL