title: DNA structure and human diseases.
abstract: Recently, multiple lines of evidences have shown that non-B DNA structures within the human genes may lead to chromosomal translocations, deletions and amplifications in cancer and other human diseases. In this review, we summarize the current literature on non-B DNA structures, and discuss their role in genomic instability and diseases.
authors.affiliation: Department of Biochemistry, Indian Institute of Science, Bangalore, India. sathees@biochem.iisc.ernet.in
authors.forename: Sathees C
authors.initials: SC
authors.lastname: Raghavan
authors.forename: Michael R
authors.initials: MR
authors.lastname: Lieber
mesh_terms: D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D004194:Disease; D006801:Humans; D009690:Nucleic Acid Conformation
chemical_list: D004247:DNA