title: [The role of chronic dental bacterial infections in the aetiopathogenesis of ischaemic heart disease].
abstract: Chronic dental infections, even of low intensity, may cause the development of atherosclerotic changes in arteries, that lead to coronary heart disease. There are many risk factors for atherosclerosis, but the most important are endothelium function disturbances, platelets activation and oxidative changes of plasmatic lipoproteins. Among factors that can induce the epithelium lesions bacterial factor may play an important role. In consequence of the bacterial cell breakdown place the release of endotoxins takes, that lead directly to the damage of endothelial cells. Apart from this direct effect endotoxins activate the fagocytes releasing superoxide reactive radicals, that cause lesions of endothelium. Probably the most widespread chronic bacterial infections in human are the diseases of periodontium and teeth and their inflammatory complications. Oral cavity is colonized by 300-400 bacterial species. In the case of dental bacterial infections bacteriemia occurs after such procedures as tooth extraction, endodontic treatment, therapeutic and hygienic interventions on periodontal tissues. The results of many investigations show the relationship between the oral status (dental and periodontal diseases as chronic oral infections) and disorders of cardiovascular system.
authors.affiliation: Zakładu Chirurgii Stomatologicznej Instytutu Stomatologii Collegium Medicum Uniwersytetu Jagiellońiskiego w Krakowie. jstypulk@cm-uj.krakow.pl
authors.forename: Jadwiga
authors.initials: J
authors.lastname: Stypułkowska
authors.forename: Robert
authors.initials: R
authors.lastname: Lyszczarz
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Błazowska
mesh_terms: D001424:Bacterial Infections / Q000150:complications* / Q000276:immunology; D003324:Coronary Artery Disease / Q000175:diagnosis / Q000276:immunology / Q000382:microbiology; D004731:Endotoxins / Q000097:blood / Q000276:immunology; D005491:Focal Infection, Dental / Q000150:complications* / Q000276:immunology; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood / Q000276:immunology; D017202:Myocardial Ischemia / Q000175:diagnosis* / Q000276:immunology / Q000382:microbiology*; D010518:Periodontitis / Q000150:complications* / Q000276:immunology; D012307:Risk Factors
chemical_list: D004731:Endotoxins; D018836:Inflammation Mediators