title: [Identification of the origin of marker chromosome by comparative genomic hybridization].
abstract: OBJECTIVE
  To identify the origin of the marker chromosome in a patient with chromosome aberration, and to provide the precise genetic diagnosis.
  
  
  METHODS
  Comparative genomic hybridization (CGH) and fluorescence in situ hybridization (FISH) were performed to detect the known small marker chromosome in this patient.
  
  
  RESULTS
  The small marker chromosome originated from chromosome 13 pter->q12.
  
  
  CONCLUSIONS
  CGH and FISH can be used to detect the small marker chromosome, which is convenient and quick in detecting the origin of small marker chromosome.
authors.affiliation: National Laboratory of Medical Genetics of China, Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Zhou
authors.forename: Ling-Qian
authors.initials: LQ
authors.lastname: Wu
authors.forename: De-Sheng
authors.initials: DS
authors.lastname: Liang
authors.forename: Qian
authors.initials: Q
authors.lastname: Pan
authors.forename: Zhi-Gao
authors.initials: ZG
authors.lastname: Long
authors.forename: He-Ping
authors.initials: HP
authors.lastname: Dai
authors.forename: Juan
authors.initials: J
authors.lastname: Li
authors.forename: Fang
authors.initials: F
authors.lastname: Cai
authors.forename: Kun
authors.initials: K
authors.lastname: Xia
authors.forename: Jia-Hui
authors.initials: JH
authors.lastname: Xia
mesh_terms: D002869:Chromosome Aberrations; D002872:Chromosome Deletion; D002882:Chromosomes, Human, Pair 13 / Q000235:genetics*; D005260:Female; D015894:Genome, Human; D006801:Humans; D017404:In Situ Hybridization, Fluorescence / Q000379:methods*; D007621:Karyotyping; D009693:Nucleic Acid Hybridization / Q000379:methods*