50-grams glucose challenge test for screening of gestational diabetes mellitus in high risk pregnancy.
OBJECTIVE
To evaluate the cutoff value of the 1-hr, 50-gram glucose challenge test (GCT) for screening of gestational diabetes mellitus (GDM), in high-risk pregnancy, and to determine the prevalence of GDM in this group.


METHODS
Descriptive study (Diagnostic test).


METHODS
Eight hundred and thirty-eight pregnant women, 24-28 weeks, were identified and recruited based on risk indicators between January and October 2004.


METHODS
A GCT was performed in this group. All women with plasma glucose value > or = 130 mg/ dl were given a 3-hr, 100-gram glucose tolerance test (OGTT) to diagnose gestational diabetes mellitus using Carpenter and Coustan diagnostic criteria. The receiver-operator characteristic (ROC) curve was used to identify the cut-off value of GCTfor detecting GDM.


METHODS
The cut-off value of GCTfor detecting GDM by using ROC curve with the sensitivity and specificity of various cut-off values.


RESULTS
The ROC curve identified a GCT value of > or = 140 mg/dl as the cut-off value for detecting GDM, which showed the sensitivity and specificity of 95.3% and 48.6% respectively. The prevalence of GDM in high-risk pregnant women was 20.17% (169/838).


CONCLUSIONS
Recommended threshold of 140 mg/dl used as the cut-off value of 50-gram, 1-hr GCTfor screening GDM in high-risk pregnancy.
Juntarat
Waraporn
W
Department of Obstetrics and Gynecology, Bhumibol Adulyadej Hospital, Phaholyothin Rd, Bangkhen, Bangkok, Thailand.
Rueangchainikhom
Wibool
W
Promas
Sinat
S
D000328:Adult; D000367:Age Factors; D001786:Blood Glucose; D016640:Diabetes, Gestational / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D008403:Mass Screening / Q000379:methods; D011247:Pregnancy; D018566:Pregnancy, High-Risk; D015995:Prevalence; D012372:ROC Curve; D012680:Sensitivity and Specificity; D013785:Thailand / Q000453:epidemiology
D001786:Blood Glucose