New insights into the combined Cockayne/xeroderma pigmentosum complex: human XPG protein can function in transcription factor stability.
A new study provides evidence supporting a function for XPG protein in maintaining the integrity and function of TFIIH (Ito et al. [2007], this issue of Molecular Cell). This observation likely explains some of the clinical features of individuals with both defective DNA repair and development.
Friedberg
Errol C
EC
Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9072, USA. errol.friedberg@utsouthwestern.edu
Wood
Richard D
RD
D003057:Cockayne Syndrome / Q000150:complications / Q000235:genetics* / Q000378:metabolism*; D018844:Cyclin-Dependent Kinases / Q000378:metabolism; D004260:DNA Repair; D004268:DNA-Binding Proteins / Q000235:genetics* / Q000378:metabolism*; D004355:Drug Stability; D004720:Endonucleases / Q000235:genetics* / Q000378:metabolism*; D006801:Humans; D009154:Mutation; D009687:Nuclear Proteins / Q000235:genetics* / Q000378:metabolism*; D051758:Transcription Factor TFIIH / Q000378:metabolism*; D014157:Transcription Factors / Q000235:genetics* / Q000378:metabolism*; D014983:Xeroderma Pigmentosum / Q000150:complications / Q000235:genetics* / Q000378:metabolism*; D000095043:Cyclin-Dependent Kinase-Activating Kinase; D000099250:DNA Excision Repair Protein ERCC-5
D018844:Cyclin-Dependent Kinases; D004268:DNA-Binding Proteins; D004720:Endonucleases; D009687:Nuclear Proteins; D051758:Transcription Factor TFIIH; D014157:Transcription Factors; D000095043:Cyclin-Dependent Kinase-Activating Kinase; D000099250:DNA Excision Repair Protein ERCC-5