title: The interplay between microRNAs and the neurotrophin receptor tropomyosin-related kinase C controls proliferation of human neuroblastoma cells.
abstract: MicroRNAs (miRNAs) are tiny noncoding RNAs whose function as modulators of gene expression is crucial for the proper control of cell growth and differentiation. Although the profile of miRNA expression has been defined for many different cellular systems, the elucidation of the regulatory networks in which they are involved is only just emerging. In this work, we identify a crucial role for three neuronal miRNAs (9, 125a, and 125b) in controlling human neuroblastoma cell proliferation. We show that these molecules act in an additive manner by repressing a common target, the truncated isoform of the neurotrophin receptor tropomyosin-related kinase C, and we demonstrate that the down-regulation of this isoform is critical for regulating neuroblastoma cell growth. Consistently with their function, these miRNAs were found to be down-modulated in primary neuroblastoma tumors.
authors.affiliation: Institute of Molecular Biology and Pathology, Consiglio Nazionale delle Ricerche (Italy).
authors.forename: Pietro
authors.initials: P
authors.lastname: Laneve
authors.forename: Lucia
authors.initials: L
authors.lastname: Di Marcotullio
authors.forename: Ubaldo
authors.initials: U
authors.lastname: Gioia
authors.forename: Micol E
authors.initials: ME
authors.lastname: Fiori
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Ferretti
authors.forename: Alberto
authors.initials: A
authors.lastname: Gulino
authors.forename: Irene
authors.initials: I
authors.lastname: Bozzoni
authors.forename: Elisa
authors.initials: E
authors.lastname: Caffarelli
mesh_terms: D045744:Cell Line, Tumor; D049109:Cell Proliferation; D006801:Humans; D035683:MicroRNAs / Q000032:analysis / Q000502:physiology*; D009447:Neuroblastoma / Q000473:pathology*; D020812:Receptor, trkC / Q000502:physiology*
chemical_list: D035683:MicroRNAs; D020812:Receptor, trkC