Vitamins and aging: pathways to NAD+ synthesis.
Recent genetic evidence reveals additional salvage pathways for NAD(+) synthesis. In this issue, Belenky et al. (2007) report that nicotinamide riboside, a new NAD(+) precursor, regulates Sir2 deacetylase activity and life span in yeast. The ability of nicotinamide riboside to enhance life span does not depend on calorie restriction.
Denu
John M
JM
Department of Biomolecular Chemistry, School of Medicine and Public Health, University of Wisconsin, 1300 University Avenue, Madison, WI 53706, USA. jmdenu@wisc.edu <jmdenu@wisc.edu>
D000375:Aging / Q000378:metabolism*; D000818:Animals; D006655:Histone Deacetylases / Q000378:metabolism*; D006801:Humans; D008136:Longevity; D009243:NAD / Q000096:biosynthesis*; D009536:Niacinamide / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology; D011726:Pyridinium Compounds; D012441:Saccharomyces cerevisiae / Q000378:metabolism*; D038281:Silent Information Regulator Proteins, Saccharomyces cerevisiae / Q000378:metabolism*; D056565:Sirtuin 2; D037761:Sirtuins / Q000378:metabolism*; D014815:Vitamins / Q000378:metabolism*
D011726:Pyridinium Compounds; D038281:Silent Information Regulator Proteins, Saccharomyces cerevisiae; D014815:Vitamins; C018613:nicotinamide-beta-riboside; D009243:NAD; D009536:Niacinamide; C087778:SIR2 protein, S cerevisiae; D056565:Sirtuin 2; D037761:Sirtuins; D006655:Histone Deacetylases