title: Gradient-based optimization of kernel-target alignment for sequence kernels applied to bacterial gene start detection.
abstract: Biological data mining using kernel methods can be improved by a task-specific choice of the kernel function. Oligo kernels for genomic sequence analysis have proven to have a high discriminative power and to provide interpretable results. Oligo kernels that consider subsequences of different lengths can be combined and parameterized to increase their flexibility. For adapting these parameters efficiently, gradient-based optimization of the kernel-target alignment is proposed. The power of this new, general model selection procedure and the benefits of fitting kernels to problem classes are demonstrated by adapting oligo kernels for bacterial gene start detection.
authors.affiliation: Institut für Neuroinformatik, Ruhr-Universität Bochum, Bochum, Germany. christian.igel@neuroinformatik.rub.de
authors.forename: Christian
authors.initials: C
authors.lastname: Igel
authors.forename: Tobias
authors.initials: T
authors.lastname: Glasmachers
authors.forename: Britta
authors.initials: B
authors.lastname: Mersch
authors.forename: Nico
authors.initials: N
authors.lastname: Pfeifer
authors.forename: Peter
authors.initials: P
authors.lastname: Meinicke
mesh_terms: D000465:Algorithms; D001185:Artificial Intelligence; D001483:Base Sequence; D018387:Codon, Initiator / Q000235:genetics*; D004269:DNA, Bacterial / Q000235:genetics*; D008969:Molecular Sequence Data; D010363:Pattern Recognition, Automated / Q000379:methods*; D016415:Sequence Alignment / Q000379:methods*; D017422:Sequence Analysis, DNA / Q000379:methods*; D024363:Transcription Initiation Site
chemical_list: D018387:Codon, Initiator; D004269:DNA, Bacterial