Soluble HLA-G and control of angiogenesis.
In this review, we summarize the results of a number of our recent in vitro and in vivo experiments demonstrating that, in addition to the immunoregulatory functions, soluble HLA-G molecules also affect endothelial cell activity. We have found that soluble HLA-G1 (also designated HLA-G5) inhibits endothelial cell proliferation, migration and tubule formation, and this occurred through binding to the CD160 receptor and via an apoptotic pathway. Moreover, we have demonstrated that soluble HLA-G1 blocks in vivo rabbit corneal neoangiogenesis. Although it cannot be excluded that other soluble HLA class I molecules may have similar effects, as soluble forms of HLA-G are being produced by trophoblast cells at the maternal-fetal interface during early gestation, we discuss how such anti-angiogenic properties of soluble HLA-G1 may locally influence uterine vascular remodeling.
Le Bouteiller
Philippe
P
INSERM U563, Centre de Physiopathologie de Toulouse-Purpan, Toulouse F-31300, France. philippe.le-bouteiller@toulouse.inserm.fr
Fons
Pierre
P
Herault
Jean-Pascal
JP
Bono
Françoise
F
Chabot
Sophie
S
Cartwright
Judith E
JE
Bensussan
Armand
A
D043924:Angiogenesis Modulating Agents / Q000378:metabolism; D000818:Animals; D015703:Antigens, CD / Q000378:metabolism*; D042783:Endothelial Cells / Q000502:physiology; D005260:Female; D058851:GPI-Linked Proteins; D006680:HLA Antigens / Q000378:metabolism*; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I / Q000378:metabolism*; D006801:Humans; D018919:Neovascularization, Physiologic; D010920:Placenta / Q000098:blood supply / Q000276:immunology; D011247:Pregnancy; D011971:Receptors, Immunologic / Q000378:metabolism*; D014327:Trophoblasts / Q000276:immunology; D014599:Uterus / Q000098:blood supply
D043924:Angiogenesis Modulating Agents; D015703:Antigens, CD; C114505:CD160 protein, human; D058851:GPI-Linked Proteins; D006680:HLA Antigens; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I; D011971:Receptors, Immunologic