Effect of tamoxifen on arterial microvascular anastomosis.
Breast reconstruction after cancer treatment is based on the circulation of pedicle and microvascular flaps. This article aimed to verify the effect of tamoxifen (TMX) pretreatment in arterial anastomosis in rats. Twenty female Wistar rats were equally divided into two groups. TMX (0.3 mg/kg) was administered to the experimental group for 2 weeks orally. After this period, the right femoral artery was sectioned and a terminoterminal anastomosis performed. The same procedure was done in the control group, except that the animals received the vehicle without TMX. One week later, the femoral arteries were inspected for flow through the anastomosis, and the vessel near it was sent to light microscopic examination. It was observed mild vasculite in both groups. The intimal thickness and total vessel wall in the TMX-treated group was significantly higher. A real thrombotic effect upon the arterial vascular anastomosis was not observed, eventhough, TMX induced intimal hyperplasia.
De Pinho Pessoa
Breno Bezerra Gomes
BB
Division of Plastic Surgery, Department of Surgery, Federal University of Ceara, Fortaleza, Brazil. breno_gpp@yahoo.com.br
Menezes Cavalcante
Bruno Bezerra
BB
Maia
Munique Pinheiro
MP
Ribeiro Filho
Haroldo H
HH
Koike
Marcia Kiyomi
MK
De Pinho Pessoa
Salustiano Gomes
SG
Porto Pinheiro
Luiz Gonzaga
LG
Montero
Edna Frasson De Souza
EF
D000714:Anastomosis, Surgical; D000818:Animals; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D005260:Female; D005263:Femoral Artery / Q000187:drug effects* / Q000473:pathology / Q000601:surgery; D008866:Microsurgery; D051381:Rats; D017208:Rats, Wistar; D013629:Tamoxifen / Q000627:therapeutic use*; D013927:Thrombosis / Q000209:etiology / Q000517:prevention & control; D014654:Vascular Patency / Q000187:drug effects*
D018931:Antineoplastic Agents, Hormonal; D013629:Tamoxifen