Variability in apo(a) gene regulatory sequences, compound genotypes, and association with Lp(a) plasma levels.
OBJECTIVE
Lipoprotein(a) is an independent risk factor of atherosclerosis.


METHODS
We assigned frequencies of six polymorphic sites from apo(a) gene transcription control regions, linkage disequilibrium, and 5-polymorphic compound genotypes association with Lp(a) levels.


RESULTS
Significant linkage disequilibrium between polymorphic sites was detected. Compound genotypes were significantly associated with Lp(a) levels (P<0.0001). Major 5-polymorphic genotypes were distributed in a broad range of concentrations.


CONCLUSIONS
Major 5-polymorphic compound genotypes are not associated with restricted range of Lp(a) levels.
Zídková
Katerina
K
3rd Medical Department, 1st Faculty of Medicine and General Teaching Hospital, Charles University, Prague, Czech Republic. kzidk@lfl.cuni.cz
Zlatohlávek
Lukás
L
Ceska
Richard
R
D001054:Apolipoproteins A / Q000235:genetics*; D001483:Base Sequence; D005838:Genotype; D006801:Humans; D017270:Lipoprotein(a) / Q000097:blood*; D011110:Polymorphism, Genetic / Q000235:genetics*
D001054:Apolipoproteins A; D017270:Lipoprotein(a)