Controlling 3(10)-helix and alpha-helix of short peptides in the solid state.
L-Leu hexapeptide containing alpha-aminoisobutyric acid (Aib) forms a right-handed (P) 3(10)-helix, whereas that containing cyclic alpha,alpha-disubstituted amino acid Ac(5)c(dOM) assumes a right-handed (P) alpha-helix in the solid state.
Demizu
Yosuke
Y
Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Fukuoka 812-8582, Japan.
Tanaka
Masakazu
M
Nagano
Masanobu
M
Kurihara
Masaaki
M
Doi
Mitsunobu
M
Maruyama
Tokumi
T
Suemune
Hiroshi
H
D000621:Aminoisobutyric Acids / Q000138:chemical synthesis; D002942:Circular Dichroism; D018360:Crystallography, X-Ray; D010455:Peptides / Q000737:chemistry*; D011487:Protein Conformation; D017433:Protein Structure, Secondary; D013055:Spectrophotometry, Infrared; D017550:Spectroscopy, Fourier Transform Infrared
D000621:Aminoisobutyric Acids; D010455:Peptides; C100049:2-aminoisobutyric acid