title: Petrous apex aspergillosis as a long-term complication of cholesterol granuloma.
abstract: Aspergillus infection of the petrous apex is a rare and devastating condition. To date, only two such cases have been reported, which resulted from direct extension of chronic Aspergillus otitis media. We present a case of petrous apex aspergillosis occurring years after surgical drainage of a petrous apex granuloma cyst. Because of the potential lethal nature of this condition, aggressive surgical therapy should be considered early in this illness and may provide the best chance for survival.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Mount Sinai School of Medicine, New York, New York 10029, USA. Jean.Anderson.Eloy@gmail.com
authors.forename: Jean Anderson
authors.initials: JA
authors.lastname: Eloy
authors.forename: Joshua B
authors.initials: JB
authors.lastname: Bederson
authors.forename: Eric E
authors.initials: EE
authors.lastname: Smouha
mesh_terms: D000666:Amphotericin B / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D001232:Aspergillus fumigatus / Q000302:isolation & purification*; D001488:Basilar Artery / Q000382:microbiology; D002559:Cerebrospinal Fluid Rhinorrhea / Q000188:drug therapy / Q000209:etiology; D002784:Cholesterol; D017809:Fatal Outcome; D015725:Fluconazole / Q000627:therapeutic use; D015745:Granuloma, Foreign-Body / Q000150:complications* / Q000601:surgery; D006261:Headache / Q000209:etiology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D016106:Methicillin Resistance; D008875:Middle Aged; D020953:Neuroaspergillosis / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D015242:Ofloxacin / Q000627:therapeutic use; D013517:Otorhinolaryngologic Surgical Procedures; D010579:Petrous Bone / Q000382:microbiology* / Q000473:pathology; D013101:Sphenoid Sinus / Q000601:surgery; D013346:Subarachnoid Space / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D000666:Amphotericin B; D015725:Fluconazole; D002784:Cholesterol; D015242:Ofloxacin