title: ERbeta ligands. Part 6: 6H-Chromeno[4,3-b]quinolines as a new series of estrogen receptor beta-selective ligands.
abstract: A new class of estrogen receptor beta (ERbeta) ligands based on the 6H-chromeno[4,3-b]quinoline scaffold has been prepared. Several C7-substituted analogues displayed high affinity and modest selectivity for ERbeta.
authors.affiliation: Chemical and Screening Sciences Medicinal Chemistry, Wyeth Research, 500 Arcola Road, Collegeville, PA 19426, USA. vua@wyeth.com
authors.forename: An T
authors.initials: AT
authors.lastname: Vu
authors.forename: Alison N
authors.initials: AN
authors.lastname: Campbell
authors.forename: Heather A
authors.initials: HA
authors.lastname: Harris
authors.forename: Rayomand J
authors.initials: RJ
authors.lastname: Unwalla
authors.forename: Eric S
authors.initials: ES
authors.lastname: Manas
authors.forename: Richard E
authors.initials: RE
authors.lastname: Mewshaw
mesh_terms: D047629:Estrogen Receptor beta / Q000378:metabolism*; D008024:Ligands; D008958:Models, Molecular; D011804:Quinolines / Q000378:metabolism*
chemical_list: D047629:Estrogen Receptor beta; D008024:Ligands; D011804:Quinolines