title: A common variant on chromosome 9p21 affects the risk of myocardial infarction.
abstract: The global endemic of cardiovascular diseases calls for improved risk assessment and treatment. Here, we describe an association between myocardial infarction (MI) and a common sequence variant on chromosome 9p21. This study included a total of 4587 cases and 12,767 controls. The identified variant, adjacent to the tumor suppressor genes CDKN2A and CDKN2B, was associated with the disease with high significance. Approximately 21% of individuals in the population are homozygous for this variant, and their estimated risk of suffering myocardial infarction is 1.64 times as great as that of noncarriers. The corresponding risk is 2.02 times as great for early-onset cases. The population attributable risk is 21% for MI in general and 31% for early-onset cases.
authors.affiliation: deCODE genetics, Sturlugata 8, IS-101 Reykjavik, Iceland.
authors.forename: Anna
authors.initials: A
authors.lastname: Helgadottir
authors.forename: Gudmar
authors.initials: G
authors.lastname: Thorleifsson
authors.forename: Andrei
authors.initials: A
authors.lastname: Manolescu
authors.forename: Solveig
authors.initials: S
authors.lastname: Gretarsdottir
authors.forename: Thorarinn
authors.initials: T
authors.lastname: Blondal
authors.forename: Aslaug
authors.initials: A
authors.lastname: Jonasdottir
authors.forename: Adalbjorg
authors.initials: A
authors.lastname: Jonasdottir
authors.forename: Asgeir
authors.initials: A
authors.lastname: Sigurdsson
authors.forename: Adam
authors.initials: A
authors.lastname: Baker
authors.forename: Arnar
authors.initials: A
authors.lastname: Palsson
authors.forename: Gisli
authors.initials: G
authors.lastname: Masson
authors.forename: Daniel F
authors.initials: DF
authors.lastname: Gudbjartsson
authors.forename: Kristinn P
authors.initials: KP
authors.lastname: Magnusson
authors.forename: Karl
authors.initials: K
authors.lastname: Andersen
authors.forename: Allan I
authors.initials: AI
authors.lastname: Levey
authors.forename: Valgerdur M
authors.initials: VM
authors.lastname: Backman
authors.forename: Sigurborg
authors.initials: S
authors.lastname: Matthiasdottir
authors.forename: Thorbjorg
authors.initials: T
authors.lastname: Jonsdottir
authors.forename: Stefan
authors.initials: S
authors.lastname: Palsson
authors.forename: Helga
authors.initials: H
authors.lastname: Einarsdottir
authors.forename: Steinunn
authors.initials: S
authors.lastname: Gunnarsdottir
authors.forename: Arnaldur
authors.initials: A
authors.lastname: Gylfason
authors.forename: Viola
authors.initials: V
authors.lastname: Vaccarino
authors.forename: W Craig
authors.initials: WC
authors.lastname: Hooper
authors.forename: Muredach P
authors.initials: MP
authors.lastname: Reilly
authors.forename: Christopher B
authors.initials: CB
authors.lastname: Granger
authors.forename: Harland
authors.initials: H
authors.lastname: Austin
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Rader
authors.forename: Svati H
authors.initials: SH
authors.lastname: Shah
authors.forename: Arshed A
authors.initials: AA
authors.lastname: Quyyumi
authors.forename: Jeffrey R
authors.initials: JR
authors.lastname: Gulcher
authors.forename: Gudmundur
authors.initials: G
authors.lastname: Thorgeirsson
authors.forename: Unnur
authors.initials: U
authors.lastname: Thorsteinsdottir
authors.forename: Augustine
authors.initials: A
authors.lastname: Kong
authors.forename: Kari
authors.initials: K
authors.lastname: Stefansson
mesh_terms: D017668:Age of Onset; D000368:Aged; D016022:Case-Control Studies; D002874:Chromosome Mapping; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics*; D003324:Coronary Artery Disease / Q000235:genetics; D005260:Female; D019942:Genes, p16; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D005838:Genotype; D006239:Haplotypes; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors