title: O2 and N2O activation by Bi-, Tri-, and tetranuclear Cu clusters in biology.
abstract: Copper-cluster sites in biology exhibit unique spectroscopic features reflecting exchange coupling between oxidized Cu's and e (-) delocalization in mixed valent sites. These novel electronic structures play critical roles in O 2 binding and activation for electrophilic aromatic attack and H-atom abstraction, the 4e (-)/4H (+) reduction of O 2 to H 2O, and in the 2e (-)/2H (+) reduction of N 2O. These electronic structure/reactivity correlations are summarized below.
authors.affiliation: Department of Chemistry, Stanford University, Stanford, California 94305, USA. Edward.Solomon@stanford.edu
authors.forename: Edward I
authors.initials: EI
authors.lastname: Solomon
authors.forename: Ritimukta
authors.initials: R
authors.lastname: Sarangi
authors.forename: Julia S
authors.initials: JS
authors.lastname: Woertink
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Augustine
authors.forename: Jungjoo
authors.initials: J
authors.lastname: Yoon
authors.forename: Somdatta
authors.initials: S
authors.lastname: Ghosh
mesh_terms: D001665:Binding Sites; D004156:Catechol Oxidase / Q000737:chemistry*; D003300:Copper / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004578:Electron Spin Resonance Spectroscopy; D006433:Hemocyanins / Q000737:chemistry*; D008958:Models, Molecular; D014442:Monophenol Monooxygenase / Q000737:chemistry*; D009609:Nitrous Oxide / Q000737:chemistry*; D010084:Oxidation-Reduction; D010088:Oxidoreductases / Q000737:chemistry; D010100:Oxygen / Q000737:chemistry*; D013440:Sulfides / Q000737:chemistry
chemical_list: D013440:Sulfides; D003300:Copper; D006433:Hemocyanins; D010088:Oxidoreductases; D004156:Catechol Oxidase; D014442:Monophenol Monooxygenase; C022763:nitrous oxide reductase; D009609:Nitrous Oxide; D010100:Oxygen