title: Aqueous humor and serum concentration of hydroxyproline in pseudoexfoliation syndrome.
abstract: OBJECTIVE
  To determine the concentration of hydroxyproline (Hyp) in aqueous humor and serum samples of patients with and without pseudoexfoliation (PEX).
  
  
  METHODS
  Aqueous humor and serum Hyp levels were measured in cataract patients. Patients were divided into PEX and control groups. Samples were obtained from 27 cataract patients with PEX and 25 cataract patients without PEX. Patients had no elevated intraocular pressure or glaucoma. Hyp concentration was determined spectrophotometrically.
  
  
  RESULTS
  Mean Hyp concentration in the PEX aqueous (0.86+/-0.27 mg/L) and serum (40.8+/-6.14 mg/L) samples was significantly higher than that measured in the control aqueous (0.56+/-0.2 mg/L) and serum (34.51+/-6.82 mg/L) samples, respectively (P<0.001, P=0.001). No significant correlation could be found between aqueous humor and serum Hyp concentrations.
  
  
  CONCLUSIONS
  The higher levels of Hyp could be a sign of increased collagen turnover in PEX syndrome.
authors.affiliation: Department of Ophthalmology, Medical School, Fatih University, Ankara, Turkey. ramazanyagci@yahoo.com
authors.forename: Ramazan
authors.initials: R
authors.lastname: Yagci
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Ersöz
authors.forename: Bahri
authors.initials: B
authors.lastname: Aydin
authors.forename: Elif
authors.initials: E
authors.lastname: Beyaz
authors.forename: Ahmet
authors.initials: A
authors.lastname: Gürel
authors.forename: Mustafa
authors.initials: M
authors.lastname: Durmuş
authors.forename: Sunay
authors.initials: S
authors.lastname: Duman
mesh_terms: D000368:Aged; D001082:Aqueous Humor / Q000378:metabolism*; D002386:Cataract / Q000150:complications; D003094:Collagen / Q000378:metabolism; D017889:Exfoliation Syndrome / Q000097:blood* / Q000150:complications; D005260:Female; D006801:Humans; D006909:Hydroxyproline / Q000097:blood*; D008297:Male; D008875:Middle Aged; D018918:Phacoemulsification
chemical_list: D003094:Collagen; D006909:Hydroxyproline