title: Function of the respiratory syncytial virus small hydrophobic protein.
abstract: Respiratory syncytial virus (RSV), a member of the Paramyxoviridae family, encodes a small hydrophobic (SH) protein of unknown function. Parainfluenza virus 5 (PIV5), a prototypical paramyxovirus, also encodes an SH protein, which inhibits tumor necrosis factor alpha (TNF-alpha) signaling. In this study, recombinant PIV5 viruses without their own SH but containing RSV SH (from RSV strain A2 or B1) in its place (PIV5DeltaSH-RSV SH) and RSV lacking its own SH (RSVDeltaSH) were generated and analyzed. The results indicate that the SH protein of RSV has a function similar to that of PIV5 SH and that it can inhibit TNF-alpha signaling.
authors.affiliation: Center of Molecular Immunology and Infectious Disease, Department of Veterinary and Biomedical Sciences, Pennsylvania State University, 115 Henning Bldg., University Park, PA 16802, USA.
authors.forename: Sandra
authors.initials: S
authors.lastname: Fuentes
authors.forename: Kim C
authors.initials: KC
authors.lastname: Tran
authors.forename: Priya
authors.initials: P
authors.lastname: Luthra
authors.forename: Michael N
authors.initials: MN
authors.lastname: Teng
authors.forename: Biao
authors.initials: B
authors.lastname: He
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D017209:Apoptosis / Q000502:physiology; D002460:Cell Line; D006801:Humans; D008969:Molecular Sequence Data; D016328:NF-kappa B / Q000378:metabolism; D045402:Parainfluenza Virus 5 / Q000378:metabolism; D012136:Respiratory Syncytial Viruses / Q000378:metabolism*; D015682:Retroviridae Proteins, Oncogenic / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D016415:Sequence Alignment; D015398:Signal Transduction / Q000502:physiology*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
chemical_list: D016328:NF-kappa B; D015682:Retroviridae Proteins, Oncogenic; D014409:Tumor Necrosis Factor-alpha; C056150:small hydrophobic protein, virus