title: Ileoscopy in patients with ileocolonic tuberculosis.
abstract: OBJECTIVE
  To study the role of retrograde terminal ileoscopy in patients suspected to have ileocolonic tuberculosis.
  
  
  METHODS
  A retrospective analysis was performed for patients undergoing colonoscopy for suspected ileocolonic tuberculosis between January 2000 and June 2004, in whom retrograde ileoscopy had been performed. Only patients diagnosed with tuberculosis on the basis of histological findings of either a caseating granuloma or those having non-caseating granuloma or a collection of epithelioid cells at a minimum of one endoscopic lesion (either in the colon or the terminal ileum) on histology with good responses to conventional anti-tuberculous drugs were enrolled for the study.
  
  
  RESULTS
  Fifty-three patients were included. The terminal ileum was involved in only 11 patients. Eight of these patients had involvement of the cecum too. Two patients had ileal lesions without cecal involvement; however, lesions were noted in the ascending colon. In one patient the whole colon was normal and only the terminal ileum showed nodularity and ulceration. Histological examination of the ileal biopsies obtained from the ileal lesions showed noncaseating granulomas in five, collection of epithelioid cells in four and nonspecific histology in two patients. Mucosal biopsies obtained from the lesion in the terminal ileum, in the patient in whom mucosal abnormality was observed to be confined to the ileum, showed noncaseating granulomas. In two other patients the ileal biopsies alone showed histological evidence of tuberculosis with biopsies from the colonic lesions showing non-specific inflammatory changes only.
  
  
  CONCLUSIONS
  Retrograde ileoscopy should be performed in all patients undergoing colonoscopy for suspected ileocolonic tuberculosis. In some patients only the terminal ileum may be involved and histological examination may reveal evidence of tuberculosis only from the lesions in the terminal ileum. This approach would lead to additional lesions being picked up and increasing the chances of well-timed diagnosis of tuberculosis.
authors.affiliation: Department of Gastroenterology, Motilal Nehru Medical College, Allahabad 211 001, India. spmisra@sancharnet.in
authors.forename: S P
authors.initials: SP
authors.lastname: Misra
authors.forename: Vatsala
authors.initials: V
authors.lastname: Misra
authors.forename: Manisha
authors.initials: M
authors.lastname: Dwivedi
mesh_terms: D000328:Adult; D001706:Biopsy; D003106:Colon / Q000473:pathology; D003108:Colonic Diseases / Q000175:diagnosis* / Q000473:pathology; D003113:Colonoscopy / Q000379:methods; D016099:Endoscopy, Gastrointestinal / Q000379:methods*; D005260:Female; D006801:Humans; D007077:Ileal Diseases / Q000175:diagnosis* / Q000473:pathology; D007082:Ileum / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D014385:Tuberculosis, Gastrointestinal / Q000175:diagnosis* / Q000473:pathology