title: Left ventricular form and function revisited: applied translational science to cardiovascular ultrasound imaging.
abstract: Doppler tissue imaging (DTI) and DTI-derived strain imaging are robust physiologic tools used for the noninvasive assessment of regional myocardial function. As a result of high temporal and spatial resolution, regional function can be assessed for each phase of the cardiac cycle and within the transmural layers of the myocardial wall. Newer techniques that measure myocardial motion by speckle tracking in gray-scale images have overcome the angle dependence of DTI strain, allowing for measurement of 2-dimensional strain and cardiac rotation. DTI, DTI strain, and speckle tracking may provide unique information that deciphers the deformation sequence of complexly oriented myofibers in the left ventricular wall. The data are, however, limited. This review examines the structure and function of the left ventricle relative to the potential clinical application of DTI and speckle tracking in assessing the global mechanical sequence of the left ventricle in vivo.
authors.affiliation: Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, USA.
authors.forename: Partho P
authors.initials: PP
authors.lastname: Sengupta
authors.forename: Vijay K
authors.initials: VK
authors.lastname: Krishnamoorthy
authors.forename: Josef
authors.initials: J
authors.lastname: Korinek
authors.forename: Jagat
authors.initials: J
authors.lastname: Narula
authors.forename: Mani A
authors.initials: MA
authors.lastname: Vannan
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Lester
authors.forename: Jamil A
authors.initials: JA
authors.lastname: Tajik
authors.forename: James B
authors.initials: JB
authors.lastname: Seward
authors.forename: Bijoy K
authors.initials: BK
authors.lastname: Khandheria
authors.forename: Marek
authors.initials: M
authors.lastname: Belohlavek
mesh_terms: D016880:Anisotropy; D015150:Echocardiography, Doppler / Q000379:methods*; D006352:Heart Ventricles / Q000000981:diagnostic imaging*; D006801:Humans; D009200:Myocardial Contraction / Q000502:physiology*; D013318:Stroke Volume / Q000502:physiology; D016276:Ventricular Function; D016277:Ventricular Function, Left / Q000502:physiology*