title: Comparing conventional gauze therapy to vacuum-assisted closure wound therapy: a prospective randomised trial.
abstract: BACKGROUND
  Vacuum-assisted closure wound therapy (vacuum therapy) has been used in our department since 1997 as a tool to bridge the period between debridement and definite surgical closure in full-thickness wounds. We performed a prospective randomised clinical trial to compare the efficacy of vacuum therapy to conventional moist gauze therapy in this stage of wound treatment.
  
  
  METHODS
  Treatment efficacy was assessed by semi-quantitative scoring of the wound conditions (signs of rubor, calor, exudate and fibrinous slough) and by wound surface area measurements. Tissue biopsies were performed to quantify the bacterial load. Besides this, the duration until 'ready for surgical therapy' and complications encountered during therapy and postoperatively were recorded.
  
  
  RESULTS
  Fifty-four patients were included (vacuum n=29, conventional n=25). With vacuum therapy, healthier wound conditions were observed. Furthermore, a tendency towards a shorter duration of therapy was found, which was most prominent in late-treated wounds. In addition, the wound surface area reduced significantly faster with vacuum therapy. Surprisingly, these results were obtained without a decrease in the number of bacteria colonising the wound. Complications were minor, except for one case of septicaemia and one case of increased tissue necrosis, which compelled us to stop vacuum therapy. For the treatment of full-thickness wounds, vacuum therapy has proven to be a valid wound healing modality.
authors.affiliation: Department of Plastic and Reconstructive Surgery, Erasmus University Medical Centre, Rotterdam, The Netherlands. moues@rdgg.nl
authors.forename: C M
authors.initials: CM
authors.lastname: Mouës
authors.forename: G J C M
authors.initials: GJ
authors.lastname: van den Bemd
authors.forename: F
authors.initials: F
authors.lastname: Heule
authors.forename: S E R
authors.initials: SE
authors.lastname: Hovius
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003646:Debridement; D006801:Humans; D053208:Kaplan-Meier Estimate; D008875:Middle Aged; D009779:Occlusive Dressings; D011183:Postoperative Complications; D011446:Prospective Studies; D016038:Skin Transplantation; D013524:Surgical Flaps; D013530:Surgical Wound Infection / Q000382:microbiology; D016896:Treatment Outcome; D014618:Vacuum; D014945:Wound Healing / Q000502:physiology; D014947:Wounds and Injuries / Q000503:physiopathology / Q000601:surgery / Q000628:therapy*