Immobilized triazine-type dehydrocondensing reagents for carboxamide formation: ROMP-Trz-Cl and ROMP(OH)-Trz-Cl.
New triazine-type dehydrocondensing reagents, such as ROMP-Trz-Cl and ROMP(OH)-Trz-Cl, were synthesized by a ring opening metathesis polymerization (ROMP) method, and these showed higher loading than conventional polymer-supported condensing reagents. These polymers effect the formation of amides in good yields by addition of a mixture of carboxylic acid, amine and NMM. ROMP(OH)-Trz-Cl, which contains hydroxyl groups in the polymer chain, gave amides in good yields even in MeOH.
Hioki
Kazuhito
K
Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Kobe 650-8586, Japan.
Kameyama
Satomi
S
Tani
Shohei
S
Kunishima
Munetaka
M
D007202:Indicators and Reagents; D011108:Polymers / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D014227:Triazines / Q000737:chemistry*
D007202:Indicators and Reagents; D011108:Polymers; C520874:ROMP(OH)-Trz-Cl; C520873:ROMP-Trz-Cl; D014227:Triazines