Osteocalcin in serum, saliva and gingival crevicular fluid: their relation with periodontal treatment outcome in postmenopausal women.
BACKGROUND
Osteocalcin levels have been postulated as a marker of inhibition of bone formation. The aim of the present study was to assess plasma, saliva and GCF levels of osteocalcin and correlate them with periodontal treatment outcome in postmenopausal women.


METHODS
Thirty-nine postmenopausal women (57.8 -/+8.5 years old) were recruited for the study. Periodontal examination of all women was carried out and plaque, bleeding on probing, probing depth (PD), and clinical attachment level (CAL) were recorded. Serum, saliva and gingival crevicular fluid osteocalcin were measured. Then, periodontal treatment was carried out. Six months after the first appointment a second periodontal examination was carried out.


RESULTS
Mean PD and mean CAL decreased significantly at second appointment in the group with serum osteocalcin concentration <10 ng/ml (15.8 -/+15.8% and 15.3 -/+ 21.2% respectively; p < 0.05). Mean PD decreased significantly at second appointment in the groups with saliva osteocalcin concentration < 3 ng/ml (17.1 -/+ 15.9%; p < 0.05) and 3-7 ng/ml (16.2 -/+18.1%; p < 0.05).


CONCLUSIONS
Low serum osteocalcin concentration is associated to a significantly higher percentage of decrease in PD and CAL after periodontal treatment in postmenopausal women. Low saliva osteocalcin concentrations are significantly associated to a higher percentage of decrease in PD.
Bullon
Pedro
P
Periodontics Department, School of Medicine, University of Sevilla, Sevilla, Spain. pbullon@us.es
Chandler
Lucy
L
Segura Egea
Juan J
JJ
Perez Cano
Ramón
R
Martinez Sahuquillo
Angel
A
D000704:Analysis of Variance; D015415:Biomarkers / Q000032:analysis / Q000097:blood; D005260:Female; D005883:Gingival Crevicular Fluid / Q000737:chemistry*; D005888:Gingival Pocket / Q000175:diagnosis; D006801:Humans; D008875:Middle Aged; D015675:Osteocalcin / Q000032:analysis* / Q000097:blood; D017622:Periodontal Attachment Loss / Q000175:diagnosis; D010510:Periodontal Diseases / Q000628:therapy*; D010518:Periodontitis / Q000628:therapy; D017698:Postmenopause; D012463:Saliva / Q000737:chemistry*
D015415:Biomarkers; D015675:Osteocalcin