An experimental study of the use of hyperbaric oxygen to reduce the side effects of radiation treatment for malignant disease.
Hyperbaric oxygen (HBO) has been used for more than 20 years to assist wound healing in the treatment of the more severe complications associated with the side effects of therapeutic radiation treatment. A prospective study was performed in an irradiated rat model to determine whether HBO is effective in reducing the long-term side effects of therapeutic radiation treatment on normal tissue, when given 1 week after the completion of the radiation treatment. The experimental model was designed to simulate a fractionated course of therapeutic radiation that is commonly used in the treatment of cancer of the mandible. One week following completion of the radiotherapy, the animals underwent a 4-week course of HBO treatment, and two animals from each group were killed at 8-week intervals until the end of the experiment at 36 weeks. Histological sections of tissue clearly showed continued growth of teeth and maintenance of specialized tissues, such as salivary gland and bone, in the treated group compared to the non-treated group. This experimental model demonstrated that HBO is effective in reducing the long-term side effects of therapeutic radiation treatment in normal tissue, when given 1 week after the completion of the radiation treatment.
Williamson
R A
RA
Faculty of Medicine and Dentistry, University of Western Australia, 17 Monash Avenue, PERTH WA 6000, Australia. raymond.williamson@iinet.net.au
D000818:Animals; D015415:Biomarkers / Q000032:analysis; D006931:Hyperbaric Oxygenation / Q000379:methods*; D008297:Male; D008334:Mandible / Q000254:growth & development; D008339:Mandibular Neoplasms / Q000532:radiotherapy*; D008962:Models, Theoretical; D011446:Prospective Studies; D011832:Radiation Injuries / Q000628:therapy*; D051381:Rats; D017208:Rats, Wistar; D012469:Salivary Glands / Q000254:growth & development; D013752:Tetracycline / Q000032:analysis; D014070:Tooth / Q000254:growth & development
D015415:Biomarkers; D013752:Tetracycline