[The effect of sodium fluoride and caffeine on concentrations of calcium, phosphorus and magnesium in rat serum].
OBJECTIVE
The aim of this study was to examine the effect of sodium fluoride and caffeine on concentrations of calcium, phosphorus, and magnesium in rat serum.


METHODS
The experiment was carried out in adult male Sprague-Dawley rats. Rats were divided into three groups of six rats. In the control group, animals received distilled water. In study group I, water was supplemented with sodium fluoride (4.9 mg F-/kg b.m./24 h), while study group II received sodium fluoride (4.9 mg F-/kg b.m./24 h) and caffeine (3 mg/kg b.m./24 h).


RESULTS
Significantly higher calcium concentrations in serum were noted after exposure to NaF and caffeine. There was a tendency to higher levels of calcium in group I. Biochemical analysis of rat serum showed unchanged concentrations of magnesium and phosphorus vs. control. In conclusion, the dose of caffeine used by us had no effect on serum markers of mineral metabolism in hard tissues.
Stawiarska-Pieta
Barbara
B
Katedra i Zakfad Patologii Slaskiej Akademii Medyczncj ul. Ostrogórska 30, 41-200 Sosnowiec.
Grucka-Mamczar
Ewa
E
Stojko
Rafał
R
Birkner
Ewa
E
Zalejska-Fiolka
Jolanta
J
D000704:Analysis of Variance; D000818:Animals; D002110:Caffeine / Q000494:pharmacology*; D002118:Calcium / Q000097:blood* / Q000737:chemistry; D004347:Drug Interactions; D008274:Magnesium / Q000097:blood* / Q000737:chemistry; D008297:Male; D010758:Phosphorus / Q000097:blood* / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D044967:Serum / Q000737:chemistry; D012969:Sodium Fluoride / Q000494:pharmacology*
D010758:Phosphorus; D002110:Caffeine; D012969:Sodium Fluoride; D008274:Magnesium; D002118:Calcium