A polysaccharide extracted from rice bran fermented with Lentinus edodes enhances natural killer cell activity and exhibits anticancer effects.
The objective of this study was to investigate the activation of natural killer (NK) cells and anticancer effects of exo-biopolymer from rice bran cultured with Lentinus edodes [rice bran exo-biopolymer (RBEP)]. Oral administration of RBEP induced the activation of NK cells in a dose-dependent manner. RBEP also prolonged the life spans of mice transplanted with Sarcoma-180 cells and inhibited growing Sarcoma-180 cells in intraperitoneum. Solid tumor growth was also suppressed by oral administration of RBEP in C57/Bl6 mice transplanted with B16/Bl6 melanoma. Intraperitoneal injection of RBEP was more effective than oral administration at the same dosage in mice with transplanted tumor cells. According to this result, when RBEP directly contacts immune cells, the anticancer activity is higher than by indirectly inducing an immune response through oral administration. Therefore, we suggest that the administration of RBEP may be effective for preventing and/or treating cancer through NK cell activation. However, further studies are needed to elucidate the possible mechanisms of the anticancer activity and to investigate the other beneficial effects of RBEP for the development of a new biological response modifier.
Kim
Hwa-Young
HY
Erom R&D Center, Erom Co., Ltd., Gyeonggi-do, Republic of Korea.
Kim
Joong-Hark
JH
Yang
Sung-Bum
SB
Hong
Seong-Gil
SG
Lee
Seong-Ae
SA
Hwang
Sung-Joo
SJ
Shin
Kwang-Soon
KS
Suh
Hyung-Joo
HJ
Park
Mi-Hyoun
MH
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage*; D004032:Diet; D005285:Fermentation; D007694:Killer Cells, Natural / Q000187:drug effects* / Q000276:immunology; D008297:Male; D008546:Melanoma, Experimental / Q000401:mortality / Q000473:pathology / Q000517:prevention & control; D051379:Mice; D008813:Mice, Inbred ICR; D009368:Neoplasm Transplantation; D012275:Oryza / Q000737:chemistry*; D011134:Polysaccharides / Q000008:administration & dosage* / Q000378:metabolism*; D012510:Sarcoma 180 / Q000401:mortality / Q000473:pathology / Q000517:prevention & control; D012639:Seeds / Q000737:chemistry; D020942:Shiitake Mushrooms / Q000378:metabolism*; D015996:Survival Rate
D000972:Antineoplastic Agents, Phytogenic; D011134:Polysaccharides