title: Reprogramming of the SWI/SNF complex for co-activation or co-repression in prohibitin-mediated estrogen receptor regulation.
abstract: The SWI/SNF complex participates as a co-activator in the transcriptional regulation of certain genes. Conversely, we and others have recently established that Brg1 and Brm, the central components of SWI/SNF, act instead as co-repressors for E2F-mediated transcriptional repression, and for the transcription of certain other promoters. We report here that Brg-1 and Brm can switch their mode of function at same promoter between activation and repression by ligand-directed differential coordination with BAF155, BAF170, HDAC1, p300 and prohibitin. This ligand and context-dependent reprogramming of the SWI/SNF complex allows it to differentially serve as either a co-repressor or a co-activator of transcription at the same promoter.
authors.affiliation: Cancer Research Center, Boston University School of Medicine, Boston, MA 02118, USA.
authors.forename: B
authors.initials: B
authors.lastname: Zhang
authors.forename: K J
authors.initials: KJ
authors.lastname: Chambers
authors.forename: D V
authors.initials: DV
authors.lastname: Faller
authors.forename: S
authors.initials: S
authors.lastname: Wang
mesh_terms: D045744:Cell Line, Tumor; D002868:Chromosomal Proteins, Non-Histone / Q000378:metabolism* / Q000502:physiology; D004265:DNA Helicases / Q000378:metabolism; D004268:DNA-Binding Proteins; D004967:Estrogens / Q000378:metabolism; D005786:Gene Expression Regulation / Q000502:physiology*; D006801:Humans; D008024:Ligands; D009687:Nuclear Proteins / Q000378:metabolism; D000091402:Prohibitins; D011960:Receptors, Estrogen / Q000235:genetics / Q000378:metabolism*; D012097:Repressor Proteins / Q000502:physiology*; D015534:Trans-Activators / Q000502:physiology*; D014157:Transcription Factors / Q000378:metabolism* / Q000502:physiology; D025521:Tumor Suppressor Proteins / Q000502:physiology*
chemical_list: D002868:Chromosomal Proteins, Non-Histone; D004268:DNA-Binding Proteins; D004967:Estrogens; D008024:Ligands; D009687:Nuclear Proteins; D000091402:Prohibitins; D011960:Receptors, Estrogen; D012097:Repressor Proteins; C084011:SMARCA2 protein, human; C101681:SMARCC1 protein, human; C101682:SMARCC2 protein, human; C445179:SWI-SNF-B chromatin-remodeling complex; D015534:Trans-Activators; D014157:Transcription Factors; D025521:Tumor Suppressor Proteins; C084108:SMARCA4 protein, human; D004265:DNA Helicases