Surgical outcome in tuberous sclerosis complex: a multicenter survey.
Multicenter, retrospective analysis of 70 subjects with TSC following surgery for relief of epilepsy revealed significant associations between younger age at seizure onset, present/prior history of infantile spasms, interictal focality (bilateral versus unilateral), and absence of residual postoperative predominant tuber, and poorer postoperative outcome (p < 0.01). Ictal multifocality, mental retardation, and discordant EEG and MRI data showed a negative trend toward outcome, but were not significant.
Madhavan
Deepak
D
Comprehensive Epilepsy Center, Department of Neurology, NYU Medical Center, 403 East 34th Street, New York, NY 10016, U.S.A. madhad01@med.nyu.edu
Schaffer
Sarah
S
Yankovsky
Alexei
A
Arzimanoglou
Alexis
A
Renaldo
Florence
F
Zaroff
Charles M
CM
LaJoie
Josiane
J
Weiner
Howard L
HL
Andermann
Eva
E
Franz
David N
DN
Leonard
Jennifer
J
Connolly
Mary
M
Cascino
Greg D
GD
Devinsky
Orrin
O
D017668:Age of Onset; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D002648:Child; D002675:Child, Preschool; D004569:Electroencephalography / Q000706:statistics & numerical data; D004828:Epilepsies, Partial / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D004827:Epilepsy / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000706:statistics & numerical data; D008297:Male; D011183:Postoperative Complications; D011300:Preoperative Care; D012189:Retrospective Studies; D016896:Treatment Outcome; D014402:Tuberous Sclerosis / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*