Effect of pinitol on glucose metabolism and adipocytokines in uncontrolled type 2 diabetes.
Pinitol (3-O-methyl-D-chiro-inositol) was identified in putative insulin mediator fractions that have hypoglycemic activity, and appears to mimic the act effects of insulin by acting downstream in the insulin signaling pathway. We evaluated the effect of pinitol therapy in type 2 diabetic patients who were poorly controlled with hypoglycemic drugs, such as sulfonylurea, metformin and/or insulin. Twenty type 2 diabetic patients were enrolled in our study. Fasting glucose, fasting c-peptide, total cholesterol, triglyceride, and HDL- and LDL-cholesterol were checked before and after a 12-week pinitol treatment (20 mg kg(-1)day(-1)). All subjects continued their current medications during the study. Adipocytokines, such as adiponectin, leptin, free fatty acids, and c-reactive protein (CRP) were checked before and after pinitol treatment. After pinitol treatment, fasting glucose, post-prandial glucose levels, and hemoglobin A1c were significantly decreased (P<0.05). Fasting serum adiponectin, leptin, free fatty acid, and CRP levels did not change after pinitol treatment. In the unresponsive group, serum c-peptide levels were higher than in the responsive group. Twelve weeks of pinitol treatment altered glucose metabolism, but not lipid profiles or adipocytokine levels, in type 2 diabetic patients. Additional research is needed to define the physiological and potential therapeutic effects of pinitol administration.
Kim
Mi Jin
MJ
Department of Internal Medicine, Hong-ik Hospital, Seoul, Korea. mijin71@naver.com
Yoo
Kwang Ha
KH
Kim
Ji Hoon
JH
Seo
Young Tak
YT
Ha
Byung Wook
BW
Kho
Jang Hyun
JH
Shin
Young Goo
YG
Chung
Choon Hee
CH
D052242:Adiponectin / Q000097:blood*; D000368:Aged; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism*; D002097:C-Reactive Protein / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D004359:Drug Therapy, Combination; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007294:Inositol / Q000031:analogs & derivatives* / Q000494:pharmacology; D020738:Leptin / Q000097:blood; D008297:Male; D008875:Middle Aged
D052242:Adiponectin; D001786:Blood Glucose; D002097:C-Reactive Protein; D005230:Fatty Acids, Nonesterified; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents; D007294:Inositol; D020738:Leptin; C021730:pinitol