title: [Diabetic neuropathy].
abstract: Diabetic neuropathy is most common chronic complication of diabetes mellitus. It is responsible for substantial morbidity, increased mortality and impaired quality of life. Patogenesis of diabetic neuropathy is complex. Chronic hyperglycemia is a major factor induces nerve fibers injury. High level of glucose stimulate the polyol pathway causing osmotic stress and enhance reactive oxygen species generation, as well as it play an important role in diabetic angiopathy development. Distal symmetric polineuropathy is most common type of diabetic neuropathy. Many patient may develop combinations of neuropathies concerning somatic and autonomic system. Early diagnosis and administered suitable treatment are necessary to reduce severe complication of diabetic neuropathy as well as strict glycemic control and risk factor increased.
authors.affiliation: Departament of Neurology and Neurorehabilitation with Stroke Unit, Clinical Hospital in Lódź, Poland.
authors.forename: Wiesław
authors.initials: W
authors.lastname: Chudzik
authors.forename: Beata
authors.initials: B
authors.lastname: Kaczorowska
authors.forename: Monika
authors.initials: M
authors.lastname: Przybyła
authors.forename: Bartosz
authors.initials: B
authors.lastname: Chudzik
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Gałka
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003920:Diabetes Mellitus / Q000175:diagnosis* / Q000453:epidemiology / Q000473:pathology / Q000503:physiopathology*; D003925:Diabetic Angiopathies / Q000175:diagnosis / Q000503:physiopathology; D017719:Diabetic Foot / Q000175:diagnosis / Q000503:physiopathology; D003929:Diabetic Neuropathies / Q000473:pathology / Q000503:physiopathology* / Q000517:prevention & control*; D018149:Glucose Intolerance / Q000175:diagnosis / Q000503:physiopathology; D006801:Humans; D006943:Hyperglycemia / Q000175:diagnosis / Q000503:physiopathology*; D007328:Insulin / Q000172:deficiency; D010525:Peripheral Nerves / Q000098:blood supply / Q000378:metabolism
chemical_list: D001786:Blood Glucose; D007328:Insulin