title: The long pentraxin 3 in cardiac surgery: distinct responses in "on-pump" and "off-pump" patients.
abstract: OBJECTIVE
  Pentraxin 3 (PTX3) is a newly identified acute phase reactant with non-redundant functions in innate immunity. The purpose of this study was to assess the kinetics of release of PTX3 in cardiac surgical patients, operated on either with or without the use of cardiopulmonary bypass (CPB).
  
  
  METHODS
  Thirty-four patients, seventeen in each group, were randomly assigned to CABG surgery performed either with ("on-pump") or without ("off-pump") CPB. Blood samples were collected both during and after the operation up to the 7(th) day.
  
  
  RESULTS
  In patients operated on with the use of CPB, PTX3 levels increased throughout the operation. Compared to baseline levels the highest PTX3 value (p<0.000) was attained on the 1(st) postoperative day in both "on-pump" and "off-pump" patients. In contrast to CPB patients, however, PTX3 levels in the latter group declined slowly, remaining elevated as long as the 3(rd) postoperative day (p<0.042).
  
  
  CONCLUSIONS
  Operations performed with the use of CPB are associated with a more pronounced release of PTX3 immediately after operation.
authors.affiliation: Department of Cardiac Surgery, Charles University in Prague, University Hospital and Faculty of Medicine in Hradec Králové, Czech Republic.
authors.forename: Pavel
authors.initials: P
authors.lastname: Kunes
authors.forename: Vladimir
authors.initials: V
authors.lastname: Lonsky
authors.forename: Jiri
authors.initials: J
authors.lastname: Mandak
authors.forename: Martina
authors.initials: M
authors.lastname: Kolackova
authors.forename: Ctirad
authors.initials: C
authors.lastname: Andrys
authors.forename: Manuela
authors.initials: M
authors.lastname: Kudlova
authors.forename: Jan
authors.initials: J
authors.lastname: Krejsek
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism*; D002315:Cardiopulmonary Bypass; D001026:Coronary Artery Bypass; D047549:Coronary Artery Bypass, Off-Pump; D005260:Female; D006801:Humans; D016753:Interleukin-10 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D000683:Serum Amyloid P-Component / Q000378:metabolism*; D016896:Treatment Outcome; D000099153:Pentraxins
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein; D016753:Interleukin-10; D015850:Interleukin-6; D000683:Serum Amyloid P-Component; D000099153:Pentraxins; C508609:IL10 protein, human; C508600:IL6 protein, human