title: EGFR and VEGFR2 protein expressions in bone metastases of clear cell renal cancer.
abstract: BACKGROUND
  EGFR and VEGFR2 protein expressions are hallmarks of clear cell renal cancer (RCC) with questionable prognostic impact. The skeletal system is one of the most common metastatic sites of RCC. Unfortunately, there are no data for EGFR and VEGFR2 protein expression in such lesions.
  
  
  METHODS
  Twenty cases of bone metastatic clear cell RCC were analyzed. EGFR and VEGFR2 proteins were detected by immunohistochemistry and analyzed by morphometry scoring both % positivity and the intensity.
  
  
  RESULTS
  EGFR protein scores were significantly reduced in bone metastases of RCC due to the reduction of EGFR protein expression in about one third of the cases (7/20). The VEGFR2 protein-positive phenotype of clear cell RCC was relatively frequent (7/20, 35%), but was lost in bone metastases (2/20, 10%).
  
  
  CONCLUSIONS
  These data suggest a phenotypic/genotypic change of clear cell RCC during the progression to bones and warrant further investigation.
authors.affiliation: Department of Orthopaedics, Semmelweis University, Budapest.
authors.forename: Gayane
authors.initials: G
authors.lastname: Badalian
authors.forename: Katalin
authors.initials: K
authors.lastname: Derecskei
authors.forename: Attila
authors.initials: A
authors.lastname: Szendroi
authors.forename: Miklós
authors.initials: M
authors.lastname: Szendroi
authors.forename: József
authors.initials: J
authors.lastname: Tímár
mesh_terms: D018262:Adenocarcinoma, Clear Cell / Q000201:enzymology* / Q000473:pathology; D000368:Aged; D001859:Bone Neoplasms / Q000196:embryology* / Q000556:secondary*; D002292:Carcinoma, Renal Cell / Q000201:enzymology* / Q000473:pathology; D066246:ErbB Receptors / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007680:Kidney Neoplasms / Q000201:enzymology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D040301:Vascular Endothelial Growth Factor Receptor-2 / Q000096:biosynthesis*
chemical_list: D066246:ErbB Receptors; D040301:Vascular Endothelial Growth Factor Receptor-2