title: Coats, tethers, Rabs, and SNAREs work together to mediate the intracellular destination of a transport vesicle.
abstract: Tethering factors have been shown to interact with Rabs and SNAREs and, more recently, with coat proteins. Coat proteins are required for cargo selection and membrane deformation to bud a transport vesicle from a donor compartment. It was once thought that a vesicle must uncoat before it recognizes its target membrane. However, recent findings have revealed a role for the coat in directing a vesicle to its correct intracellular destination. In this review we will discuss the literature that links coat proteins to vesicle targeting events.
authors.affiliation: Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06519, USA.
authors.forename: Huaqing
authors.initials: H
authors.lastname: Cai
authors.forename: Karin
authors.initials: K
authors.lastname: Reinisch
authors.forename: Susan
authors.initials: S
authors.lastname: Ferro-Novick
mesh_terms: D000818:Animals; D001692:Biological Transport; D020756:Coatomer Protein / Q000378:metabolism*; D006801:Humans; D021122:Protein Subunits / Q000378:metabolism; D050600:SNARE Proteins / Q000378:metabolism*; D022161:Transport Vesicles / Q000378:metabolism*; D020691:rab GTP-Binding Proteins / Q000378:metabolism*
chemical_list: D020756:Coatomer Protein; D021122:Protein Subunits; D050600:SNARE Proteins; D020691:rab GTP-Binding Proteins