title: BOLD sensitivity to cortical activation induced by microstimulation: comparison to visual stimulation.
abstract: Electrical microstimulation via intracortical electrodes is a widely used method for deducing functions of the brain. In this study, we compared the spatial extent and amplitude of BOLD responses evoked by intracortical electrical stimulation in primary visual cortex with BOLD activations evoked by visual stimulation. The experiments were performed in anesthetized rhesus monkeys. Visual stimulation yielded activities larger than predicted from the well-established visual magnification factor. However, electrical microstimulation yielded an even greater spread of the BOLD response. Our results confirm that the effects of electrical microstimulation extend beyond the brain region expected to be excited by direct current spread.
authors.affiliation: Department of Cognitive Neurology, HIH for Clinical Brain Research, University Tuebingen, 72076 Tuebingen, Germany. fahad.sultan@uni-tuebingen.de
authors.forename: Fahad
authors.initials: F
authors.lastname: Sultan
authors.forename: Mark
authors.initials: M
authors.lastname: Augath
authors.forename: Nikos
authors.initials: N
authors.lastname: Logothetis
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism / Q000473:pathology; D001931:Brain Mapping / Q000379:methods; D002540:Cerebral Cortex / Q000033:anatomy & histology* / Q000473:pathology*; D003627:Data Interpretation, Statistical; D004558:Electric Stimulation; D004594:Electrophysiology; D007091:Image Processing, Computer-Assisted; D008253:Macaca mulatta; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009474:Neurons / Q000378:metabolism