Tetanic potentiation in motor units of rat medial gastrocnemius.
Tetanic potentiation is a phenomenon, which expresses the ability of a motor unit (MU) to increase its force output in tetanic contractions above that predicted with an assumption of algebraic summation of single twitch responses. To quantify tetanic potentiation, a coefficient TPC (tetanic potentiation coefficient) was defined as a ratio of the areas below tetanic force recording corresponding to the single stimulus contribution and that of the single twitch. Single MUs (27 Slow, 71 Fast, Fatigue Resistant, and 47 Fast, Fatigable) were isolated from the rat medial gastrocnemius muscle (MG) by ventral root splitting. TPC value was rate-dependent, with the maximum TPCmax at a certain optimal rate. The largest values of the TPCmax were obtained in the weakest and most fatigue resistant (S and weak FR) MUs. The different manifestation of staircase effect, post-tetanic and tetanic potentiation in individual MU types indicates that these phenomena may be independent of each other. We suggest that these phenomena as well as the fatigue resistance should be reexamined with protocols adjusted to the MU optimal frequency.
Piotrkiewicz
Maria
M
Institute of Biocybernetics and Biomedical Engineering, 4 Ks. Trojdena St., 02-109 Warsaw, Poland. masia@ibib.waw.pl.
Celichowski
Jan
J
D000818:Animals; D004307:Dose-Response Relationship, Radiation; D004558:Electric Stimulation / Q000379:methods; D004576:Electromyography / Q000379:methods; D005071:Evoked Potentials / Q000502:physiology*; D005260:Female; D009046:Motor Neurons / Q000502:physiology*; D009119:Muscle Contraction / Q000502:physiology / Q000528:radiation effects; D018763:Muscle Fatigue / Q000502:physiology / Q000528:radiation effects; D018482:Muscle, Skeletal / Q000166:cytology*; D051381:Rats; D017208:Rats, Wistar