title: B-cell neurolymphomatosis confined to the peripheral nervous system.
abstract: Patients with neurolymphomatosis show lymphoma cells within the peripheral nerves, nerve root/plexus, or cranial nerves. However, most neurolymphomatosis patients show lymphomatous infiltration not only in the peripheral nervous system (PNS), but also in the meninges, Virchow-Robin space, and brain parenchyma. Here, we report a 74-year-old woman with diffuse large B-cell lymphoma presenting with motor-sensory-autonomic polyneuropathy and multiple cranial neuropathies. A diagnosis of neurolymphomatosis was made by sural nerve biopsy. Postmortem examination indicated that lymphoma cell infiltration in the nervous system was confined to the PNS with no involvement of the central nervous system, including the meninges. This was a very rare case of B-cell neurolymphomatosis with lymphomatous infiltration confined to the PNS, suggesting specific affinity of the lymphoma cells for the PNS in this patient.
authors.affiliation: Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Science, 13-1, Takara-machi, Kanazawa, Ishikawa, 920-8640, Japan. ashibata@med.kanazawa-u.ac.jp
authors.forename: Ayumi
authors.initials: A
authors.lastname: Shibata-Hamaguchi
authors.forename: Miharu
authors.initials: M
authors.lastname: Samuraki
authors.forename: Eisuke
authors.initials: E
authors.lastname: Furui
authors.forename: Chiho
authors.initials: C
authors.lastname: Ishida
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kitagawa
authors.forename: Shinji
authors.initials: S
authors.lastname: Nakao
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Minato
authors.forename: Masahito
authors.initials: M
authors.lastname: Yamada
mesh_terms: D000368:Aged; D001402:B-Lymphocytes / Q000473:pathology; D003389:Cranial Nerve Diseases / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D003391:Cranial Nerves / Q000473:pathology / Q000503:physiopathology; D018450:Disease Progression; D004211:Disseminated Intravascular Coagulation / Q000209:etiology / Q000503:physiopathology; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D016393:Lymphoma, B-Cell / Q000150:complications* / Q000473:pathology* / Q000503:physiopathology; D009361:Neoplasm Invasiveness / Q000473:pathology* / Q000503:physiopathology; D010525:Peripheral Nerves / Q000473:pathology* / Q000503:physiopathology; D010523:Peripheral Nervous System Diseases / Q000209:etiology* / Q000473:pathology* / Q000503:physiopathology; D013126:Spinal Nerve Roots / Q000473:pathology / Q000503:physiopathology