Efficacy of a silicone urinary catheter impregnated with chlorhexidine and triclosan against colonization with Proteus mirabilis and other uropathogens.
We sought to develop an infection-resistant urinary catheter. We evaluated 3 types of catheters for their efficacy against uropathogens in an in vitro model of the urinary tract. The catheter impregnated with chlorhexidine and triclosan suppressed the growth of uropathogens, including Proteus mirabilis, for 20-30 days or longer.
Gaonkar
Trupti A
TA
Department of Surgery, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA. smm4@columbia.edu
Caraos
Lauserpina
L
Modak
Shanta
S
D000890:Anti-Infective Agents / Q000008:administration & dosage*; D001419:Bacteria / Q000145:classification / Q000187:drug effects; D002710:Chlorhexidine / Q000008:administration & dosage*; D016503:Drug Delivery Systems; D004866:Equipment Contamination / Q000517:prevention & control; D006801:Humans; D066298:In Vitro Techniques; D008422:Materials Testing; D016106:Methicillin Resistance / Q000187:drug effects; D009583:Nitrofurazone / Q000008:administration & dosage; D011513:Proteus mirabilis / Q000187:drug effects*; D012828:Silicones; D012837:Silver Sulfadiazine / Q000008:administration & dosage; D013997:Time Factors; D014260:Triclosan / Q000008:administration & dosage*; D014546:Urinary Catheterization / Q000295:instrumentation*; D020713:Vancomycin Resistance / Q000187:drug effects
D000890:Anti-Infective Agents; D012828:Silicones; D014260:Triclosan; D002710:Chlorhexidine; D012837:Silver Sulfadiazine; D009583:Nitrofurazone