title: Avian and human metapneumovirus.
abstract: Pneumovirus infection remains a significant problem for both human and veterinary medicine. Both avian pneumovirus (aMPV, Turkey rhinotracheitis virus) and human metapneumovirus (hMPV) are pathogens of birds and humans, which are associated with respiratory tract infections. Based on their different genomic organization and low level of nucleotide (nt) and amino acid (aa) identity with paramyxoviruses in the genus Pneumovirus, aMPV and hMPV have been classified into a new genus referred to as Metapneumovirus. The advancement of our understanding of pneumovirus biology and pathogenesis of pneumovirus disease in specific natural hosts can provide us with strategies for vaccine formulations and combined antiviral and immunomodulatory therapies.
authors.affiliation: Department of Microbiology, All India Institute of Medical Sciences Hospital, New Delhi, India. shobha.broor@gmail.com
authors.forename: Shobha
authors.initials: S
authors.lastname: Broor
authors.forename: Preeti
authors.initials: P
authors.lastname: Bharaj
mesh_terms: D000818:Animals; D001715:Bird Diseases / Q000821:virology*; D001717:Birds; D016679:Genome, Viral; D006801:Humans; D029121:Metapneumovirus / Q000145:classification / Q000235:genetics / Q000302:isolation & purification / Q000502:physiology*; D018184:Paramyxoviridae Infections / Q000662:veterinary* / Q000821:virology*; D012141:Respiratory Tract Infections / Q000662:veterinary* / Q000821:virology*; D014764:Viral Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology; D053586:Virus Internalization
chemical_list: D014764:Viral Proteins