title: Dorsal root entry zone lesions for treatment of pain-related to radiation-induced plexopathy.
abstract: METHODS
  Case series.
  
  
  OBJECTIVE
  Presentation of results of dorsal root entry zone lesions in 10 patients suffering from severe neuropathic pain due to brachial plexopathy or radiation-induced trigeminal neuropathy.
  
  
  BACKGROUND
  Radiation-induced neuropathy is an uncommon but serious complication of radiotherapy. It may cause delayed motor and sensitive impairment associated with severe treatment-resistant pain. Various therapeutic approaches have been reported aimed at controlling radiation-induced neuropathy-pain, demonstrating poor outcomes.
  
  
  METHODS
  Eight patients with plexopathy underwent dorsal root entry zone lesion in the cervical spinal cord, while 2 other subjects received stereotactic trigeminal nucleotractotomy. Subjects were followed prospectively before and after brachial dorsal root entry zone or trigeminal caudal operations (range 0.5-36 months).
  
  
  RESULTS
  All patients experienced improvement in pain conditions. A total of 8 patients reported full pain relief (visual analog scale = 0) by the end of the follow-up period. The remaining patients had partial control of pain. One patient required reoperation to achieve optimal pain relief. Both patients who underwent trigeminal nucleotractotomy had transient ataxia in the ipsilateral upper limb. One of the patients treated by dorsal root entry zone lesion had minor aggravation of weakness of the ipsilateral lower limb.
  
  
  CONCLUSIONS
  The present results suggest that the trigeminal nucleotractotomy and dorsal root entry zone lesions in cervical spinal cord are an effective procedure for the treatment of pain associated with actinic peripheral neuropathy.
authors.affiliation: Department of Neurology and Division of Functional Neurosurgery, Hospital das Clínicas, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.
authors.forename: Manoel Jacobsen
authors.initials: MJ
authors.lastname: Teixeira
authors.forename: Erich Talamoni
authors.initials: ET
authors.lastname: Fonoff
authors.forename: Myriam Carolina
authors.initials: MC
authors.lastname: Montenegro
mesh_terms: D000328:Adult; D000368:Aged; D020516:Brachial Plexus Neuropathies / Q000209:etiology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011832:Radiation Injuries / Q000601:surgery*; D011878:Radiotherapy / Q000009:adverse effects*; D019051:Rhizotomy / Q000379:methods*; D013126:Spinal Nerve Roots / Q000601:surgery*; D013238:Stereotaxic Techniques; D016896:Treatment Outcome; D014277:Trigeminal Neuralgia / Q000209:etiology / Q000601:surgery*