[Conservative treatment undifferentiated neuroendocrine tumors of the anal canal: two cases].
Undifferentiated neuroendocrine tumors are rare, and are characteristically aggressive with a poor prognosis. Most patients have metastatic disease at diagnosis, and cannot undergo curative surgical treatment. A chemotherapy regimen combining etoposide plus cisplatin is currently considered to be the reference treatment. We report two cases of poorly differentiated neuroendocrine tumors localized in the anal canal and treated by chemotherapy and radiotherapy resulting in prolonged complete local remission and preventing extended surgical excision.
Lepère
Céline
C
Service d'Hépato-Gastroentérologie et d'oncologie digestive, Fédération des spécialités digestives, Hôpital Ambroise Paré, Boulogne-Billancourt, France. celine.lepere@apr.aphp.fr
Rakotomalala
Suzy
S
Maindrault-Goebel
Frédérique
F
Mitry
Emmanuel
E
Vaillant
Jean-Nicolas
JN
Julie
Catherine
C
Otmezguine
Yves
Y
Rougier
Philippe
P
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000368:Aged; D001003:Anal Canal / Q000473:pathology; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001005:Anus Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy / Q000628:therapy*; D001706:Biopsy; D001932:Brain Neoplasms / Q000188:drug therapy / Q000401:mortality / Q000532:radiotherapy / Q000556:secondary*; D002945:Cisplatin / Q000008:administration & dosage / Q000627:therapeutic use; D003131:Combined Modality Therapy; D005047:Etoposide / Q000008:administration & dosage / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D018358:Neuroendocrine Tumors / Q000188:drug therapy / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy / Q000556:secondary / Q000628:therapy*; D011879:Radiotherapy Dosage; D012074:Remission Induction; D013997:Time Factors
D000305:Adrenal Cortex Hormones; D000970:Antineoplastic Agents; D000972:Antineoplastic Agents, Phytogenic; D005047:Etoposide; D002945:Cisplatin