title: New cytotoxic cembranolides from the soft coral Lobophytum michaelae.
abstract: Eleven new cytotoxic cembranolides, michaolides A-K (1-11), and crassolide (12) were isolated from the CH(2)Cl(2) extract of the Formosan soft coral Lobophytum michaelae. Their structures were established by extensive spectral analysis. The cytotoxicity of the isolates against selected cancer cells was measured in vitro.
authors.affiliation: Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung, 804 Taiwan.
authors.forename: Li-Tang
authors.initials: LT
authors.lastname: Wang
authors.forename: Shang-Kewi
authors.initials: SK
authors.lastname: Wang
authors.forename: Keryea
authors.initials: K
authors.lastname: Soong
authors.forename: Chang-Yih
authors.initials: CY
authors.lastname: Duh
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000302:isolation & purification* / Q000494:pharmacology*; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000302:isolation & purification* / Q000494:pharmacology*; D019073:HT29 Cells; D006801:Humans; D007783:Lactones / Q000302:isolation & purification* / Q000494:pharmacology*; D007941:Leukemia P388 / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D019086:Bridged Bicyclo Compounds, Heterocyclic; D007783:Lactones