[Effect of hypoxia on mesenchymal stem cells - review].
Oxygen is essential for life, but cultivation of cells is usually performed under 20% O(2), that do not replicate normal physiological hypoxia or pathological hypoxia conditions in the body. Recently, the effect of hypoxia on mesenchymal stem cells (MSCs) has been studied, under physiological hypoxia, MSCs thrive well, and the ability differentiating to osteoblast, chondrocyte and adipocyte as well as the ability of migration are changed. Hypoxia changes the physiological characteristics of embryonic stem cell, hematopoietic stem cell and neuron stem cell as well. The mechanism of these responses might be primarily involved in the hypoxic inducible factor-1 (HIF-1) signal pathway. This review emphasizes that hypoxia is an important factor on all major aspects of stem cell biology including survival, proliferation, differentiation, and migration, and the mechanism involved in HIF-1 signaling pathway behind these responses was also discussed.
He
Mi-Chun
MC
Center of Tissue Engineering, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing 100005, China.
Li
Jing
J
Zhao
Chun-Hua
CH
D000818:Animals; D002454:Cell Differentiation; D015687:Cell Hypoxia / Q000502:physiology; D002465:Cell Movement; D049109:Cell Proliferation; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000378:metabolism*; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000502:physiology*; D015398:Signal Transduction
D051795:Hypoxia-Inducible Factor 1, alpha Subunit