Cytokinetic pyrotechnics.
Cytokinesis, the final step in cell division, is dependent on formation and closure of a ring of actin filaments (F-actin) and myosin-2 which is, in turn, dependent on activation of the small GTPase, RhoA, at the cell equator. Four new papers, including two in this issue of Developmental Cell (Petronczki et al., 2007; Birkenfeld et al., 2007), provide new insights into how RhoA activation at the equator is initiated and maintained.
Bement
William M
WM
Department of Zoology, Program in Cellular and Molecular Biology, University of Wisconsin-Madison, 1117 West Johnson Street, Madison, WI 53706, USA. wmbement@wisc.edu
D018797:Cell Cycle Proteins / Q000378:metabolism; D048749:Cytokinesis; D004789:Enzyme Activation; D020662:Guanine Nucleotide Exchange Factors / Q000235:genetics / Q000378:metabolism; D006801:Humans; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D011518:Proto-Oncogene Proteins / Q000378:metabolism; D064067:Rho Guanine Nucleotide Exchange Factors; D008941:Spindle Apparatus / Q000378:metabolism; D020742:rhoA GTP-Binding Protein / Q000378:metabolism; D000097869:Polo-Like Kinase 1
D018797:Cell Cycle Proteins; D020662:Guanine Nucleotide Exchange Factors; D017346:Protein Serine-Threonine Kinases; D011518:Proto-Oncogene Proteins; D064067:Rho Guanine Nucleotide Exchange Factors; D020742:rhoA GTP-Binding Protein; D000097869:Polo-Like Kinase 1; C577356:ARHGEF2 protein, human; C489850:ECT2 protein, human