Neuroprotection of G-CSF in cerebral ischemia.
In several experimental studies of cerebral ischemia, G-CSF exerts neuroprotective effects through different mechanisms, including mobilization of hematopoietic stem cells, anti-apoptosis, neuronal differentiation, angiogenesis and anti-inflammation. Hence, G-CSF not only inhibits neuron death, but also generates "new" neural tissue formation. A small pilot trial reports on the safety and feasibility of G-CSF therapy in stroke patients. According to this evidence, we can speculate that G-CSF, being used either alone or in combination with another agent, should be an effective strategy in the treatment of cerebral ischemia.
Lu
Chuan-Zhen
CZ
Institute of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Xiao
Bao-Guo
BG
D000818:Animals; D002545:Brain Ischemia / Q000188:drug therapy / Q000503:physiopathology*; D016179:Granulocyte Colony-Stimulating Factor / Q000502:physiology* / Q000627:therapeutic use; D006801:Humans; D018696:Neuroprotective Agents / Q000627:therapeutic use
D018696:Neuroprotective Agents; D016179:Granulocyte Colony-Stimulating Factor