title: Phylogenetic groups and virulence factors of Escherichia coli strains causing pyelonephritis in children with and without urinary tract abnormalities.
abstract: Escherichia coli isolates causing acute pyelonephritis in 93 children (25% with urinary tract abnormalities) were tested for nine virulence factors (papC, papGII, papGIII, sfa/foc, hlyC, cnf1, iucC, fyuA and iroN) and their phylogenetic groups were determined. Isolates lacking papGII were more frequent among patients with urinary tract abnormalities (58% vs. 10%, p 0.0003), as were non-virulent phylogenetic group A isolates (25% vs. 5%, p 0.043). Pyelonephritis caused by less virulent E. coli strains was more frequent among patients with significant urinary tract abnormalities. Further studies are required to determine whether screening for E. coli virulence factors may help to identify children warranting anatomical investigations.
authors.affiliation: Laboratoire d'Etudes de Génétique Bactérienne dans les Infections de l'Enfant (EA3105), Université Denis Diderot-Paris 7, Paris, France.
authors.forename: V
authors.initials: V
authors.lastname: Houdouin
authors.forename: S
authors.initials: S
authors.lastname: Bonacorsi
authors.forename: F
authors.initials: F
authors.lastname: Mahjoub-Messai
authors.forename: P
authors.initials: P
authors.lastname: Mariani-Kurkdjian
authors.forename: P
authors.initials: P
authors.lastname: Bidet
authors.forename: G
authors.initials: G
authors.lastname: Sebag
authors.forename: C
authors.initials: C
authors.lastname: Loirat
authors.forename: A
authors.initials: A
authors.lastname: Bourrillon
authors.forename: E
authors.initials: E
authors.lastname: Bingen
mesh_terms: D000208:Acute Disease; D018830:Adhesins, Escherichia coli / Q000235:genetics / Q000378:metabolism; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004926:Escherichia coli / Q000235:genetics / Q000378:metabolism / Q000472:pathogenicity*; D004927:Escherichia coli Infections / Q000382:microbiology; D029968:Escherichia coli Proteins / Q000235:genetics; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D010802:Phylogeny; D011704:Pyelonephritis / Q000382:microbiology*; D014551:Urinary Tract / Q000002:abnormalities*; D037521:Virulence Factors / Q000235:genetics* / Q000378:metabolism
chemical_list: D018830:Adhesins, Escherichia coli; D029968:Escherichia coli Proteins; C519334:PapGII protein, E coli; D037521:Virulence Factors