The use of tissue engineering and stem cells in bladder regeneration.
Tissue engineering techniques for bladder regeneration have been applied successfully for many years in a variety of in vitro and in vivo models. But despite these rapid advances, to date, none of the tissue-engineered constructs could be used in human models due to inconsistent results of the described techniques in animal models. Three factors have been identified to influence the regeneration process: identification of the ideal scaffold, appropriate cell population for seeding and the optimal regeneration conditions necessary. Identifying the role of each component will help to unlock the complex regeneration mechanisms required to achieve consistent, reliable results that will allow transition of the technology into clinical practice. This review will discuss the role and applicability of the each factor and provide a future prospective on tissue engineering techniques for bladder regeneration.
Frimberger
Dominic
D
Department of Urology, University of Oklahoma Health Sciences Center, 920 SL Young Boulevard, WP 3150, Oklahoma City, OK 73190, USA. Dominic-frimberger@ouhsc.edu
Lin
H K
HK
Kropp
Bradley P
BP
D000818:Animals; D006801:Humans; D023421:Models, Animal; D012038:Regeneration; D013234:Stem Cells / Q000166:cytology*; D023822:Tissue Engineering; D001743:Urinary Bladder / Q000166:cytology / Q000502:physiology*