title: 2-Chloro-6-(2-furyl)-9-(4-methoxybenzyl)-9H-purine.
abstract: The title compound, C(17)H(13)ClN(4)O(2), displays profound and selective activity against Mycobacterium tuberculosis. In the crystal structure, there are two independent molecules in the asymmetric unit. Intermolecular hydrogen bonding between a CH group of the purine ring and the O atom of the furan ring, and also pi-pi stacking in another direction, builds the three-dimensional network.
authors.affiliation: Department of Chemistry, University of Oslo, PO Box 1033, Blindern, N-0315 Oslo, Norway. morten.brandvang@kjemi.uio.no
authors.forename: Morten
authors.initials: M
authors.lastname: Braendvang
authors.forename: Lise Lotte
authors.initials: LL
authors.lastname: Gundersen
mesh_terms: D000995:Antitubercular Agents / Q000737:chemistry* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D006860:Hydrogen Bonding; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D011687:Purines / Q000737:chemistry* / Q000494:pharmacology
chemical_list: C500168:2-chloro-6-(2-furyl)-9-(4-methoxyphenylmethyl)-9H-purine; D000995:Antitubercular Agents; D011687:Purines