Nutritional deficiencies in celiac disease.
Celiac disease is characterized by small bowel enteropathy, precipitated in genetically susceptible individuals by the ingestion of "gluten," which is a term used to encompass the storage proteins of wheat, rye, and barley. Although the intestine heals with removal of gluten from the diet, the intolerance is permanent and the damage recurs if gluten is reintroduced. This damage causes a wide variety of consequence including maldigestion and malabsorption, resulting in the characteristic, although not universal, features of malnutrition. This article examines recent advances in the understanding of the spectrum of celiac disease, illustrates the impact of celiac disease on nutrition, and describes approaches to the management of the disease.
Barton
Susan H
SH
Division of Gastroenterology and Hepatology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
Kelly
Darlene G
DG
Murray
Joseph A
JA
D000328:Adult; D002446:Celiac Disease / Q000150:complications* / Q000175:diagnosis / Q000178:diet therapy / Q000453:epidemiology; D018753:Diet, Protein-Restricted; D005260:Female; D005983:Glutens / Q000009:adverse effects; D006801:Humans; D008286:Malabsorption Syndromes / Q000175:diagnosis / Q000178:diet therapy / Q000453:epidemiology / Q000209:etiology; D008297:Male; D044342:Malnutrition / Q000175:diagnosis / Q000178:diet therapy / Q000453:epidemiology / Q000209:etiology*; D008875:Middle Aged
D005983:Glutens