title: Assessment of thyroid function and urinary and breast milk iodine concentrations in healthy newborns and their mothers in Tehran.
abstract: OBJECTIVE
  To measure breast milk iodine (MI) and urinary iodine (UI) concentrations in healthy newborns and their nursing mothers from an iodine-sufficient region to determine adequacy and to relate these parameters to thyroid function tests in mothers and infants.
  
  
  METHODS
  Cross-sectional.
  
  
  METHODS
  Forty-eight healthy neonates of 37 to 42 weeks' gestation with normal cord blood TSH values and their mothers were recruited in Tehran, Iran.
  
  
  METHODS
  Serum thyroid function tests were performed, and maternal and infant urinary iodine excretion, and maternal MI concentration were measured.
  
  
  RESULTS
  Neonatal age was 12.9 +/- 3.9 (mean +/- SD; range 7-30) days and maternal age was 25.8 +/- 5 years. Median (range) UI in neonates was 271 microg/l (57-800) and in mothers was 107 microg/l (20-710). Median (range) MI was 148 microg/l (45-750). Neonatal and maternal UI did not correlate with serum thyroid function tests. UI < 150, 150-230, and > 230 microg/l was found in 20, 12.5, and 67.5% of neonates and 79.1, 14, and 7% of mothers, respectively. MI was < 150, 150-180, and > 180 microg/l in 52.4, 11.9, and 35.7% of mothers, respectively.
  
  
  CONCLUSIONS
  Among euthyroid neonates, UI was adequate despite low median maternal UI and MI concentrations. There were no significant correlations between UI or MI and thyroid function tests in the mothers and infants.
authors.affiliation: Endocrine Research Center, Shaheed Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Arash
authors.initials: A
authors.lastname: Ordookhani
authors.forename: Elizabeth N
authors.initials: EN
authors.lastname: Pearce
authors.forename: Mehdi
authors.initials: M
authors.lastname: Hedayati
authors.forename: Parvin
authors.initials: P
authors.lastname: Mirmiran
authors.forename: Sanam
authors.initials: S
authors.lastname: Salimi
authors.forename: Fereidoun
authors.initials: F
authors.lastname: Azizi
authors.forename: Lewis E
authors.initials: LE
authors.lastname: Braverman
mesh_terms: D000328:Adult; D001942:Breast Feeding; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007231:Infant, Newborn / Q000378:metabolism* / Q000652:urine; D007455:Iodine / Q000032:analysis* / Q000652:urine; D007492:Iran; D008895:Milk, Human / Q000737:chemistry*; D013960:Thyroid Function Tests; D013961:Thyroid Gland / Q000502:physiology*
chemical_list: D007455:Iodine