Successful salvage of a relapsed high risk gestational trophoblastic neoplasia patient using capecitabine.
BACKGROUND
Although most patients at high risk of Gestational Trophoblastic Neoplasia (GTN) respond to standard treatments, there is a group of patients that will die because of it. The use of new single or combination drugs in this population has become a priority.


METHODS
We present the case of a relapsed high risk choriocarcinoma patient who did not respond to several chemotherapy treatments nor to PET guided salvage surgery. Because of treatment toxicity, the patient was started on Capecitabine, with which she achieved total remission, still present after 15 months of starting treatment.


CONCLUSIONS
The use of Capecitabine and the multidisciplinary management of this population should be taken into account for patients at high risk of relapsing to EP/EMA because of its efficacy and little toxicity.
Bianconi
M
M
Obstetrics and Gynecology Division, Hospital Durand, Buenos Aires, Argentina.
Jankilevich
G
G
Otero
S
S
Nassif
J
J
Storino
C
C
D000328:Adult; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use*; D000069287:Capecitabine; D002822:Choriocarcinoma / Q000188:drug therapy*; D003841:Deoxycytidine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D005472:Fluorouracil / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D011247:Pregnancy; D012307:Risk Factors; D016879:Salvage Therapy; D014328:Trophoblastic Neoplasms / Q000188:drug therapy*
D000964:Antimetabolites, Antineoplastic; D003841:Deoxycytidine; D000069287:Capecitabine; D005472:Fluorouracil