title: Lbx1 acts as a selector gene in the fate determination of somatosensory and viscerosensory relay neurons in the hindbrain.
abstract: Distinct types of relay neurons in the hindbrain process somatosensory or viscerosensory information. How neurons choose between these two fates is unclear. We show here that the homeobox gene Lbx1 is essential for imposing a somatosensory fate on relay neurons in the hindbrain. In Lbx1 mutant mice, viscerosensory relay neurons are specified at the expense of somatosensory relay neurons. Thus Lbx1 expression distinguishes between the somatosensory or viscerosensory fate of relay neurons.
authors.affiliation: Department of Neuroscience, Max-Delbrück-Center for Molecular Medicine, Berlin, Germany.
authors.forename: Martin A
authors.initials: MA
authors.lastname: Sieber
authors.forename: Robert
authors.initials: R
authors.lastname: Storm
authors.forename: Margaret
authors.initials: M
authors.lastname: Martinez-de-la-Torre
authors.forename: Thomas
authors.initials: T
authors.lastname: Müller
authors.forename: Hagen
authors.initials: H
authors.lastname: Wende
authors.forename: Katja
authors.initials: K
authors.lastname: Reuter
authors.forename: Elena
authors.initials: E
authors.lastname: Vasyutina
authors.forename: Carmen
authors.initials: C
authors.lastname: Birchmeier
mesh_terms: D000818:Animals; D005801:Genes, Homeobox / Q000502:physiology; D008040:Genetic Linkage / Q000502:physiology; D051379:Mice; D008817:Mice, Mutant Strains; D009124:Muscle Proteins / Q000096:biosynthesis / Q000235:genetics* / Q000502:physiology; D009474:Neurons; D009475:Neurons, Afferent / Q000166:cytology / Q000378:metabolism*; D012249:Rhombencephalon / Q000166:cytology / Q000378:metabolism / Q000502:physiology*; D017833:Visceral Afferents / Q000166:cytology / Q000378:metabolism*
chemical_list: C491868:Lbx1h protein, mouse; D009124:Muscle Proteins