[Functional models of movement disorders of basal ganglia origin and effects of functional neurosurgery].
The rate model regarding the development of movement disorders of basal ganglia origin suggests that hyperkinetic and hypokinetic disorders occur as a result of changes in the firing rates in the GPi and SNr, which in turn suppress thalamocortical output. Dopamine depletion in Parkinson's disease increases basal ganglia output, then decreases thalamocortical output, leading to bradykinesia. This model, however, cannot explain a lack of deterioration of parkinsonian signs following thalamic coagulation surgery. Instead of the rate model, the beta oscillation hypothesis has been proposed, explaining that synchronized oscillation in the beta frequency in the basal ganglia disturbs initiation of voluntary movement. We observed that effective high-frequency STN stimulation in parkinsonian monkeys was associated with increase in the firing rate and the pattern shift from irregular burst firing to regular high-frequency firing in the projecting sites. High-frequency neural activation by deep brain stimulation is supposed to cancel lower frequency oscillation including beta oscillation, leading to improvement of bradykinesia. Our observation supports the significance of the neural activity pattern, rather than the tonic activity level, in the development of movement disorders. The rate model cannot explain the improvement of ballismus and chorea by pallidotomy because pallidotomy increases the disinhibition of the thalamocortical projection, which should increase the movements. We observed repetitive bursts or pauses of neuronal firing of the globus pallidus synchronized to ballistic movements in patients with hemiballism or chorea, suggesting that phasic neuronal driving in the basal ganglia is important as their pathophysiology.
Hashimoto
Takao
T
Center for Neurological Diseases, Aizawa Hospital.
D000818:Animals; D001479:Basal Ganglia / Q000473:pathology / Q000503:physiopathology*; D001480:Basal Ganglia Diseases / Q000503:physiopathology* / Q000601:surgery; D004195:Disease Models, Animal; D004576:Electromyography; D000882:Haplorhini; D009069:Movement Disorders / Q000503:physiopathology* / Q000601:surgery; D019635:Neurosurgical Procedures; D010300:Parkinson Disease / Q000503:physiopathology