Convenient synthesis of photoaffinity probes and evaluation of their labeling abilities.
Convenient synthesis of a variety of photoaffinity probes was accomplished by utilizing our Ns strategy and novel resin. The synthetic probes were evaluated via the labeling ability with the preseniline 1 C-terminal fragments, which was identified as a therapeutic target for Alzheimer's disease.
Kan
Toshiyuki
T
School of Pharmaceutical Sciences, University of Shizuoka, Suruga-ku, Shizuoka 422-8526, Japan.
Kita
Yoichi
Y
Morohashi
Yuichi
Y
Tominari
Yusuke
Y
Hosoda
Shinnosuke
S
Tomita
Taisuke
T
Natsugari
Hideaki
H
Iwatsubo
Takeshi
T
Fukuyama
Tohru
T
D015394:Molecular Structure; D019920:Photoaffinity Labels / Q000032:analysis / Q000138:chemical synthesis* / Q000737:chemistry*; D053764:Presenilin-1 / Q000737:chemistry*
D019920:Photoaffinity Labels; D053764:Presenilin-1