title: BRAF T1799A mutation occurring in a case of malignant struma ovarii.
abstract: Struma ovarii is an extremely rare tumor that occasionally undergoes malignant transformation. Because struma ovarii is composed of thyroid tissue, it is conceivable that the pathogenetic events involved in thyroid follicular transformation may take place also in struma ovarii. The authors describe a case of a classical variant of papillary thyroid carcinoma arising in a struma ovarii of a 22-year-old female. The tumor was heterozygous for BRAF T1799A mutation. No ret/ PTC-1 or ret/PTC-3 rearrangements were detected. This finding would suggest that malignant struma ovarii is similar histologically and genetically to primary papillary thyroid carcinoma.
authors.affiliation: Departments of Histopathology, St. James's Hospital, Trinity College, Dublin, Ireland.
authors.forename: Richard
authors.initials: R
authors.lastname: Flavin
authors.forename: Paul
authors.initials: P
authors.lastname: Smyth
authors.forename: Paul
authors.initials: P
authors.lastname: Crotty
authors.forename: Stephen
authors.initials: S
authors.lastname: Finn
authors.forename: Susanne
authors.initials: S
authors.lastname: Cahill
authors.forename: Karen
authors.initials: K
authors.lastname: Denning
authors.lastname: Jinghuan Li
authors.forename: Esther
authors.initials: E
authors.lastname: O'Regan
authors.forename: John
authors.initials: J
authors.lastname: O'Leary
authors.forename: Orla
authors.initials: O
authors.lastname: Sheils
mesh_terms: D000328:Adult; D018265:Carcinoma, Papillary, Follicular / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D004273:DNA, Neoplasm / Q000032:analysis; D005260:Female; D006579:Heterozygote; D006801:Humans; D009154:Mutation; D010051:Ovarian Neoplasms / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D048493:Proto-Oncogene Proteins B-raf / Q000235:genetics* / Q000378:metabolism; D012334:RNA, Neoplasm / Q000032:analysis; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013330:Struma Ovarii / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D013964:Thyroid Neoplasms / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D013965:Thyroidectomy; D016896:Treatment Outcome
chemical_list: D004273:DNA, Neoplasm; D012334:RNA, Neoplasm; C482119:BRAF protein, human; D048493:Proto-Oncogene Proteins B-raf