Small cell cancer of the anal canal--case report of a rare tumor.
BACKGROUND
We report on a rare case of small cell cancer located at the anal canal.


METHODS
A 41-year old woman presented with locally advanced small cell anal cancer and simultaneous hepatic and pulmonal deposits. Due to metastatic disease, chemotherapy with etoposide and cisplatin was performed with mixed response after four cycles of chemotherapy. After application of two additional chemotherapy cycles, locally progressive disease occurred causing symptomatic bowel obstruction. Pelvic irradiation was started and, several days later, additional irradiation of cerebral metastases was initiated due to rapid progression of distant disease. Despite adequate local treatment the patient's condition further deteriorated and irradiation was stopped. The patient died 10 months after initial diagnosis due to rapid tumor progression.


CONCLUSIONS
In patients with metastatic small cell anal cancer chemotherapy remains the mainstay of therapy. Radiotherapy exerts additional activity and remains a prime choice to gain local control and ameliorate symptoms. Careful histopathological examination, together with immunohistochemistry, is needed to determine the therapeutic strategy to be followed.
Meyer
Andreas
A
Department of Radiation Oncology, Hannover Medical School, Carl-Neuberg-Strasse 1, D-30625 Hannover, Germany. andie.meyer@gmx.net
Bruns
Frank
F
Richter
Klaus
K
Grünwald
Viktor
V
Karstens
Johann H
JH
D000328:Adult; D001005:Anus Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy / Q000628:therapy*; D018288:Carcinoma, Small Cell / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy / Q000628:therapy*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans