ERbeta ligands. Part 6: 6H-Chromeno[4,3-b]quinolines as a new series of estrogen receptor beta-selective ligands.
A new class of estrogen receptor beta (ERbeta) ligands based on the 6H-chromeno[4,3-b]quinoline scaffold has been prepared. Several C7-substituted analogues displayed high affinity and modest selectivity for ERbeta.
Vu
An T
AT
Chemical and Screening Sciences Medicinal Chemistry, Wyeth Research, 500 Arcola Road, Collegeville, PA 19426, USA. vua@wyeth.com
Campbell
Alison N
AN
Harris
Heather A
HA
Unwalla
Rayomand J
RJ
Manas
Eric S
ES
Mewshaw
Richard E
RE
D047629:Estrogen Receptor beta / Q000378:metabolism*; D008024:Ligands; D008958:Models, Molecular; D011804:Quinolines / Q000378:metabolism*
D047629:Estrogen Receptor beta; D008024:Ligands; D011804:Quinolines