Specialized inhibitory synaptic actions between nearby neocortical pyramidal neurons.
We found that, in the mouse visual cortex, action potentials generated in a single layer-2/3 pyramidal (excitatory) neuron can reliably evoke large, constant-latency inhibitory postsynaptic currents in other nearby pyramidal cells. This effect is mediated by axo-axonic ionotropic glutamate receptor-mediated excitation of the nerve terminals of inhibitory interneurons, which connect to the target pyramidal cells. Therefore, individual cortical excitatory neurons can generate inhibition independently from the somatic firing of inhibitory interneurons.
Ren
Ming
M
Department of Neuroscience, Research Institute of Environmental Medicine, Nagoya University, Nagoya 464-8601, Japan.
Yoshimura
Yumiko
Y
Takada
Naoki
N
Horibe
Shoko
S
Komatsu
Yukio
Y
D000200:Action Potentials; D000818:Animals; D001369:Axons / Q000378:metabolism; D004558:Electric Stimulation; D019706:Excitatory Postsynaptic Potentials; D018698:Glutamic Acid / Q000378:metabolism / Q000494:pharmacology; D053444:Inhibitory Postsynaptic Potentials; D007395:Interneurons / Q000502:physiology; D051379:Mice; D008810:Mice, Inbred C57BL; D009433:Neural Inhibition; D018408:Patch-Clamp Techniques; D017729:Presynaptic Terminals / Q000502:physiology; D017966:Pyramidal Cells / Q000502:physiology*; D018091:Receptors, AMPA / Q000502:physiology; D018092:Kainic Acid Receptors / Q000502:physiology; D013569:Synapses / Q000502:physiology*; D009435:Synaptic Transmission; D014793:Visual Cortex / Q000166:cytology / Q000502:physiology*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D018698:Glutamic Acid; D018091:Receptors, AMPA; D018092:Kainic Acid Receptors; D005680:gamma-Aminobutyric Acid