Successful treatment of disseminated fusariosis with posaconazole during neutropenia and subsequent allogeneic hematopoietic stem cell transplantation.
We report the case of a 16-year-old girl with acute myelogenous leukemia with disseminated fusariosis, who responded to salvage posaconazole therapy. She subsequently received additional cytotoxic chemotherapy and allogeneic hematopoietic stem cell transplantation with posaconazole continued as secondary prophylaxis. Despite intensive immunosuppressive therapy for graft-versus-host disease, no recrudescence of infection occurred.
Gupta
S
S
Department of Medicine, School of Medicine and Biochemical Sciences, SUNY at Buffalo, Buffalo, New York, USA.
Almyroudis
N G
NG
Battiwalla
M
M
Bambach
B J
BJ
McCarthy
P L
PL
Proefrock
A D
AD
Ball
D
D
Paplham
P
P
Varma
A
A
Kwon-Chung
J
J
Segal
B H
BH
D000293:Adolescent; D000935:Antifungal Agents / Q000627:therapeutic use*; D005260:Female; D005670:Fusarium / Q000187:drug effects / Q000302:isolation & purification*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications; D009181:Mycoses / Q000188:drug therapy*; D009503:Neutropenia / Q000150:complications*; D014230:Triazoles / Q000627:therapeutic use*
D000935:Antifungal Agents; D014230:Triazoles; C101425:posaconazole