title: Degradation and drug release properties of poly-alpha,beta-[N-(2-hydroxyethyl)-L-aspartamide]-g-poly(2,2-dimethyltrimethylene carbonate).
abstract: A series of biodegradable amphiphilic graft copolymers with poly-alpha,beta-[N-(2-hydroxyethyl)-L-aspartamide] (PHEA) as the backbone and poly(2,2-dimethyltrimethylene carbonate) (PDTC) segments with different lengths as the grafted branches were synthesized and characterized. The in vitro degradation of the obtained PHEA-g-PDTC copolymers was studied. With particular branch lengths, PHEA-g-PDTC can form self-assembling micelles in an aqueous solution. Transmission electron microscopy (TEM) images demonstrated that the micelles were regularly spherical in shape. The particle size and distribution of the micelles were measured. Nanoparticle drug delivery systems were prepared by the direct dissolution method. The in vitro release behaviors of two drugs, prednisone acetate and tegafur, with different water solubilities were investigated.
authors.affiliation: Key Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan University, Wuhan, PR China.
authors.forename: Tao
authors.initials: T
authors.lastname: Peng
authors.forename: Jing
authors.initials: J
authors.lastname: Su
authors.forename: Si-Xue
authors.initials: SX
authors.lastname: Cheng
authors.forename: Ren-Xi
authors.initials: RX
authors.lastname: Zhuo
mesh_terms: D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry*; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles / Q000737:chemistry / Q000648:ultrastructure; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry*; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*; D011241:Prednisone / Q000008:administration & dosage; D012995:Solubility; D005641:Tegafur / Q000008:administration & dosage; D014867:Water
chemical_list: D001672:Biocompatible Materials; D003692:Delayed-Action Preparations; D010455:Peptides; D011108:Polymers; C008965:alpha,beta-poly((2-hydroxyethyl)-aspartamide); D014867:Water; D005641:Tegafur; D011241:Prednisone