title: Expression of monocyte chemoattractant protein-1 in idiopathic dilated cardiomyopathy.
abstract: Immunological factors have been involved in the pathogenesis of dilated cardiomyopathy (DCM). The cytotoxic action of macrophages is one of the main factors causing cardiac myocyte damage. Monocyte chemoattractant protein-1 (MCP-1) is a major signal for the accumulation of monocytes/macrophages. We examined whether MCP-1 was expressed in the myocardium of DCM patients and whether the expression level was correlated with the degree of impairment of cardiac function. The expression of MCP-1 in the myocardium was determined by immunohistochemistry in endomyocardial biopsy samples from 13 patients. The expression of MCP-1 was found in all myocardial samples from DCM patients but not in those from control subjects. Positive staining for MCP-1 was distinct in cardiac myocytes, interstitium and infiltrating cells. Semi-quantitative analysis revealed that the expression of MCP-1 was inversely correlated with left ventricular ejection fraction. In conclusion, the expression level of MCP-1 in the myocardium was correlated with the degree of impairment of cardiac function in patients with DCM.
authors.forename: Makoto
authors.initials: M
authors.lastname: Kobayashi
authors.forename: Kazufumi
authors.initials: K
authors.lastname: Nakamura
authors.forename: Kengo Fukushima
authors.initials: KF
authors.lastname: Kusano
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Keiko
authors.initials: K
authors.lastname: Ohta-Ogo
authors.forename: Satoshi
authors.initials: S
authors.lastname: Nagase
authors.forename: Satoru
authors.initials: S
authors.lastname: Sakuragi
authors.forename: Tohru
authors.initials: T
authors.lastname: Ohe
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000032:analysis; D001707:Biopsy, Needle; D002311:Cardiomyopathy, Dilated / Q000401:mortality* / Q000473:pathology* / Q000503:physiopathology; D016022:Case-Control Studies; D018932:Chemokine CCL2 / Q000097:blood / Q000378:metabolism*; D018450:Disease Progression; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005500:Follow-Up Studies; D006334:Heart Function Tests; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D011336:Probability; D012333:RNA, Messenger / Q000032:analysis; D012016:Reference Values; D012189:Retrospective Studies; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D015996:Survival Rate
chemical_list: D015415:Biomarkers; D018932:Chemokine CCL2; D012333:RNA, Messenger