[Analysis of the distribution of the nucleotide sequence and electrostatic potential of the Escherichia coli genome].
The oligonucleotide composition of the E. coli genome and its sigma70-specific promoters has been analyzed. The promoter DNA was shown to contain mainly AT-rich hexanucleotides having functionally important physical properties such as the ability to form easily melting sites and induce the bending of the double helix. A comparative analysis of the electrostatic characteristics of hexanucleotides within the whole sequence of the E. coli genome and its promoter regions was made. Hexanucleotides possessing a more electronegative surrounding were found to predominate in the nucleotide sequence of the promoter DNA.
Sorokin
A A
AA
Osipov
A A
AA
Beskaravaĭnyĭ
P M
PM
Kamzolova
S G
SG
D001483:Base Sequence / Q000235:genetics; D012321:DNA-Directed RNA Polymerases / Q000378:metabolism; D004926:Escherichia coli / Q000235:genetics* / Q000502:physiology*; D016680:Genome, Bacterial / Q000235:genetics*; D008564:Membrane Potentials; D011401:Promoter Regions, Genetic / Q000235:genetics*; D017422:Sequence Analysis, DNA; D012808:Sigma Factor / Q000378:metabolism; D055672:Static Electricity
D012808:Sigma Factor; C081775:RNA polymerase sigma 70; D012321:DNA-Directed RNA Polymerases