Antiinflammatory activity of an herbal preparation (HemoHIM) in rats.
This study evaluated a new herbal preparation, HemoHIM, for its antiinflammatory activity against carrageenan-induced edema, the formation of granulation tissues by cotton pellet and experimental colitis by 2,4,6-trinitrobenzene sulfonic acid (TNBS). The HemoHIM was prepared by adding its ethanol-insoluble polysaccharide fraction to the total water extract of Angelica Radix, Cnidii Rhizoma and Paeonia Radix. The preparation (4 mg of solids/mL of drinking water, p.o., 50-100 mg/kg of body weight, i.p.) produced a dose-related inhibition of carrageenan-induced paw edema and cotton pellet-induced granuloma in rats. In addition, HemoHIM also reduced the degree of TNBS-induced colitis and improved the gross and histological changes such as thickening, dilatation, ulceration, and infiltration by polymorphonuclear leukocytes and multiple erosive lesions. These results demonstrate that the HemoHIM has a potent antiinflammatory effect.
Jo
Sung Kee
SK
Advanced Radiation Technology Institute, Jeongeup Campus of Korea Atomic Energy Research Institute (KAERI), Jeongeup 580-185, South Korea.
Lee
Hae June
HJ
Kim
Se Ra
SR
Kim
Jong Choon
JC
Bae
Chun Sik
CS
Jung
Uhee
U
Park
Hae Ran
HR
Jang
Jong Sik
JS
Kim
Sung Ho
SH
D000284:Administration, Oral; D029969:Angelica; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D002351:Carrageenan; D031048:Cnidium; D003092:Colitis / Q000139:chemically induced / Q000517:prevention & control; D032561:Cotton Fiber; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control*; D015745:Granuloma, Foreign-Body / Q000139:chemically induced / Q000517:prevention & control; D008297:Male; D029596:Paeonia; D008517:Phytotherapy; D028321:Plant Preparations / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018517:Plant Roots; D010946:Plants, Medicinal; D051381:Rats; D017207:Rats, Sprague-Dawley; D027343:Rhizome; D014302:Trinitrobenzenesulfonic Acid
D000894:Anti-Inflammatory Agents, Non-Steroidal; D028321:Plant Preparations; D014302:Trinitrobenzenesulfonic Acid; D002351:Carrageenan