Differences in two mice strains on kainic acid-induced amygdalar seizures.
Seizure susceptibility and neurodegeneration induced by microinjection of kainic acid (KA) into the left amygdala (LA) in C57BL/6 and FVB/N mouse strains were compared. Mice were administered 0.5 microg of KA into the LA. Electroencephalograms (EEGs) and behavior were monitored for 48 h after KA microinjection. Neuronal cell damages in the CA1 and CA3 regions of hippocampus were assessed at 2 and 48 h after KA microinjection. We demonstrated that the FVB/N mice showed longer duration of seizure activity than the C57BL/6 mice in EEGs and behavioral observation. The C57BL/6 mice were resistant to neurodegeneration while the FVB/N mice were vulnerable as measured 2 and 48 h after KA microinjection. These differences might be associated with genetic background.
Kasugai
Motofumi
M
Department of Psychiatry, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan.
Akaike
Koichi
K
Imamura
Shin-ichi
S
Matsukubo
Hideyuki
H
Tojo
Hideshi
H
Nakamura
Masayuki
M
Tanaka
Shigeya
S
Sano
Akira
A
D000679:Amygdala / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology*; D000818:Animals; D007608:Kainic Acid; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D012640:Seizures / Q000139:chemically induced* / Q000473:pathology / Q000503:physiopathology*; D013045:Species Specificity
D007608:Kainic Acid