Relation of increased hemoglobin A(1c) levels to severity of peripheral arterial disease in patients with diabetes mellitus.
The association between hemoglobin A(1c) levels and the severity of peripheral arterial disease (PAD) was investigated in 224 patients with diabetes mellitus and PAD. The mean hemoglobin A(1c) levels were 9.1 +/- 2.1% in patients with diabetes with ankle-brachial indexes (ABIs) <0.60 and 7.1 +/- 0.9% in those with ABIs of 0.60 to 0.89 (p <0.0001). Hemoglobin A(1c) levels <6.5% were present in 2 of 89 patients with diabetes (2%) with ABIs <0.60 and in 24 of 135 (18%) with ABIs of 0.60 to 0.89 (p = 0.0004). Hemoglobin A(1c) levels <7.0% were present in 24 of 89 patients with diabetes (27%) with ABIs <0.60 and in 63 of 135 (47%) with ABIs of 0.60 to 0.89 (p = 0.003). Hemoglobin A(1c) levels <7.5% were present in 30 of 89 patients with diabetes (34%) with ABIs <0.60 and in 92 of 135 (68%) with ABIs of 0.60 to 0.89 (p <0.0001). In conclusion, the higher the hemoglobin A(1c) levels in patients with diabetes with PAD, the higher the prevalence of severe PAD.
Aronow
Wilbert S
WS
Department of Medicine, Cardiology Division, New York Medical College, Valhalla, NY, USA. wsaronow@aol.com
Ahn
Chul
C
Weiss
Melvin B
MB
Babu
Sateesh
S
D000368:Aged; D000842:Ankle / Q000098:blood supply; D015415:Biomarkers / Q000097:blood; D001916:Brachial Artery / Q000378:metabolism / Q000473:pathology*; D048909:Diabetes Complications / Q000097:blood*; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016491:Peripheral Vascular Diseases / Q000097:blood*; D015995:Prevalence; D012720:Severity of Illness Index
D015415:Biomarkers; D006442:Glycated Hemoglobin