MscS, the bacterial mechanosensitive channel of small conductance.
The mechanosensitive channel of small conductance, MscS, is one of the most extensively studied MS channels to date. Past and present research involves the discovery of its physiological role as an emergency valve in prokaryotes up to detailed investigations of its conductive properties and gating mechanism. In this review, we summarize the findings on its structure and function obtained by experimental and theoretical approaches. A special focus is given to its pharmacology, since various compounds have been shown to affect the activity of this channel. These compounds have particularly been helpful for understanding the interaction of MscS with the lipid bilayer, as well as recognizing the potential of this channel as a target for novel types of antibiotics.
Hurst
Annette C
AC
School of Biomedical Sciences, University of Queensland, St. Lucia, Qld 4072, Australia. a.hurst@uq.edu.au
Petrov
Evgeny
E
Kloda
Anna
A
Nguyen
Thom
T
Hool
Livia
L
Martinac
Boris
B
D001426:Bacterial Proteins / Q000737:chemistry / Q000502:physiology*; D029968:Escherichia coli Proteins / Q000737:chemistry / Q000502:physiology; D015640:Ion Channel Gating / Q000502:physiology*; D007473:Ion Channels / Q000737:chemistry / Q000502:physiology; D040542:Mechanotransduction, Cellular / Q000502:physiology*; D008958:Models, Molecular; D017434:Protein Structure, Tertiary
D001426:Bacterial Proteins; D029968:Escherichia coli Proteins; D007473:Ion Channels; C469542:MscS protein, E coli