Normal percentage of CD56bright natural killer cells in young patients with a history of repeated unexplained implantation failure after in vitro fertilization cycles.
Changes in endometrial leukocyte subpopulations and most of all in the percentage of uterine natural-killer cells (uNK), during the menstrual cycles, may have a pivotal role in the implantation process. An increase of activated NK cells (CD56dim CD16+ CD69+) in the peripheral blood of patients with a reduced rate of embryo implantation in IVF treatment has been reported elsewhere, but we found, by using flow cytometry, normal endometrial lymphocyte subpopulations in young patients with a history of repeated unexplained implantation failure who were undergoing IVF cycles for idiopathic infertility.
Matteo
Maria G
MG
Operative Unit of Obstetrics and Gynecology, Department of Surgical Sciences, University of Foggia, Foggia, Italy. m.matteo@unifg.it
Greco
Pantaleo
P
Rosenberg
Piergiorgio
P
Mestice
Anna
A
Baldini
Domenico
D
Falagario
Teresa
T
Martino
Vincenzo
V
Santodirocco
Michele
M
Massenzio
Francesca
F
Castellana
Laura
L
Specchia
Giorgina
G
Liso
Arcangelo
A
D000328:Adult; D019002:CD56 Antigen / Q000032:analysis*; D010064:Embryo Implantation; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro; D005434:Flow Cytometry; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D014599:Uterus / Q000166:cytology
D019002:CD56 Antigen