title: Arterial hypertension and cognitive dysfunction in physiologic and pathologic aging of the brain.
abstract: Arterial hypertension is the most important modifiable cerebrovascular risk factor; its relationship with cerebrovascular disease is continuous, consistent, and independent. Different and probably converging pathophysiologic mechanisms explain the role of arterial hypertension in causing cognitive dysfunction in pathologic aging of the brain, specifically, vascular dementia and Alzheimer's disease.
authors.affiliation: Section of Neurology, University of Perugia, Perugia, Italy.
authors.forename: Alessia
authors.initials: A
authors.lastname: Lanari
authors.forename: Giorgio
authors.initials: G
authors.lastname: Silvestrelli
authors.forename: Pierangelo
authors.initials: P
authors.lastname: De Dominicis
authors.forename: Daniele
authors.initials: D
authors.lastname: Tomassoni
authors.forename: Francesco
authors.initials: F
authors.lastname: Amenta
authors.forename: Lucilla
authors.initials: L
authors.lastname: Parnetti
mesh_terms: D000368:Aged; D000375:Aging / Q000473:pathology / Q000502:physiology; D000544:Alzheimer Disease / Q000175:diagnosis / Q000503:physiopathology*; D001158:Arteries / Q000473:pathology; D001921:Brain / Q000473:pathology; D003071:Cognition / Q000502:physiology; D015140:Dementia, Vascular / Q000175:diagnosis / Q000503:physiopathology*; D015577:Geriatric Assessment; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*