title: Urine macrophage migration inhibitory factor in pediatric systemic lupus erythematosus.
abstract: We reported a series of ten patients with lupus nephritis (five patients in the relapse phase and five in the remission phase) and measured the macrophage migration inhibitory factor (MIF), an important pro-inflammatory cytokine with probable role in the pathogenesis of many inflammatory diseases, in their urine samples. MIF/creatinine (Cr) ratio directly correlated with disease activity and it does not have any significant difference between inactive disease and normal ones. We found that the urine MIF/Cr ratio not only differentiates active disease from inactive disease and normal ones but also correlates with the activity indices of renal pathology.
authors.affiliation: Aliasghar Children's Hospital, Tehran, Iran.
authors.forename: Hasan
authors.initials: H
authors.lastname: Otukesh
authors.affiliation: Aliasghar Children's Hospital, Tehran, Iran. m.chalian@gmail.com.
authors.forename: Majid
authors.initials: M
authors.lastname: Chalian
authors.affiliation: Aliasghar Children's Hospital, Tehran, Iran.
authors.forename: Rozita
authors.initials: R
authors.lastname: Hoseini
authors.affiliation: Aliasghar Children's Hospital, Tehran, Iran.
authors.forename: Hamid
authors.initials: H
authors.lastname: Chalian
authors.affiliation: Aliasghar Children's Hospital, Tehran, Iran.
authors.forename: Nakysa
authors.initials: N
authors.lastname: Hooman
authors.affiliation: Aliasghar Children's Hospital, Tehran, Iran.
authors.forename: Arash
authors.initials: A
authors.lastname: Bedayat
authors.affiliation: Iran University of Medical Sciences and Health Services, Tehran, Iran.
authors.forename: Reza Salman
authors.initials: RS
authors.lastname: Yazdi
authors.affiliation: Iran University of Medical Sciences and Health Services, Tehran, Iran.
authors.forename: Saeed
authors.initials: S
authors.lastname: Sabaghi
authors.affiliation: Iran University of Medical Sciences and Health Services, Tehran, Iran.
authors.forename: Saeed
authors.initials: S
authors.lastname: Mahdavi
mesh_terms: D000293:Adolescent; D015415:Biomarkers / Q000652:urine; D002648:Child; D018450:Disease Progression; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis / Q000652:urine*; D008263:Macrophage Migration-Inhibitory Factors / Q000652:urine*; D008297:Male; D011379:Prognosis; D011446:Prospective Studies; D012008:Recurrence; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers; D008263:Macrophage Migration-Inhibitory Factors