title: [Synthetic fragments of the NS1 protein of the tick-borne encephalitis virus exhibiting a protective effect].
abstract: Potentially immunoactive regions of the NS1 nonstructural protein of the tick-borne encephalitis virus that can stimulate the antibody formation in vivo and protect animals from this disease were chosen on the basis of theoretical calculations. Eleven 16- to 27-aa peptides containing the chosen regions were synthesized. The ability of the free peptides (without any high-molecular-mass carrier) to stimulate the production of antipeptide antibodies in mice of three lines and ensure the formation of protective immunity was studied. Most of these peptides were shown to exhibit the immunogenic activity in a free state. Five fragments that can protect mice from the infection by a lethal dose of tick-borne encephalitis virus were found.
authors.forename: T D
authors.initials: TD
authors.lastname: Volkova
authors.forename: D O
authors.initials: DO
authors.lastname: Koroev
authors.forename: M A
authors.initials: MA
authors.lastname: Titova
authors.forename: M B
authors.initials: MB
authors.lastname: Oboznaia
authors.forename: M P
authors.initials: MP
authors.lastname: Filatova
authors.forename: M F
authors.initials: MF
authors.lastname: Vorovich
authors.forename: S V
authors.initials: SV
authors.lastname: Ozherelkov
authors.forename: A V
authors.initials: AV
authors.lastname: Timofeev
authors.forename: O M
authors.initials: OM
authors.lastname: Vol'pina
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D004675:Encephalitis, Tick-Borne / Q000517:prevention & control*; D007114:Immunization; D051379:Mice; D008815:Mice, Inbred Strains; D008969:Molecular Sequence Data; D010455:Peptides / Q000737:chemistry / Q000276:immunology* / Q000627:therapeutic use; D017361:Viral Nonstructural Proteins / Q000737:chemistry / Q000276:immunology* / Q000627:therapeutic use
chemical_list: D000914:Antibodies, Viral; C100315:NS1 protein, Flavivirus; D010455:Peptides; D017361:Viral Nonstructural Proteins