Antidepressant-like effects of Albizzia julibrissin in mice: involvement of the 5-HT1A receptor system.
The present study was undertaken to investigate the antidepressant-like effects of the methylene chloride fraction of Albizzia julibrissin (MCAJ) using a tail suspension test in mice. MCAJ was orally administered at 50, 100, or 200 mg/kg to mice, 1 h before the tail suspension test. Acute treatment with MCAJ at 200 mg/kg significantly reduced the immobility time compared with the control group, and thus showed an antidepressant-like effect. This effect was comparable to that of imipramine at 10 mg/kg. This antidepressant-like effect was reversed by treatment with WAY-100635 (a 5-HT1A receptor antagonist) or pindolol (a 5-HT1A/1B receptor antagonist). However, the antidepressant effect of MCAJ was not effected by treatment with GR55562 (a 5-HT1B receptor antagonist) or ketanserin (a 5-HT2A receptor antagonist). Therefore, our findings suggest that MCAJ exerts its antidepressant-like effect via the 5-HT1A receptor system.
Kim
Ji-Hyun
JH
Department of Pharmacology, College of Pharmacy, Sungkyunkwan University, Suwon 440-746, Republic of Korea.
Kim
Sun Yeou
SY
Lee
Seok-Yong
SY
Jang
Choon-Gon
CG
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D031289:Albizzia / Q000737:chemistry*; D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D001549:Benzamides / Q000494:pharmacology; D001831:Body Temperature / Q000187:drug effects; D019417:Hindlimb Suspension; D007650:Ketanserin / Q000494:pharmacology; D008297:Male; D008752:Methylene Chloride; D051379:Mice; D008813:Mice, Inbred ICR; D009043:Motor Activity / Q000187:drug effects; D010869:Pindolol / Q000494:pharmacology; D010879:Piperazines / Q000494:pharmacology; D010936:Plant Extracts / Q000494:pharmacology; D011725:Pyridines / Q000494:pharmacology; D044282:Receptor, Serotonin, 5-HT1A / Q000187:drug effects*; D012702:Serotonin Antagonists / Q000494:pharmacology; D012997:Solvents
D000319:Adrenergic beta-Antagonists; D000928:Antidepressive Agents; D001549:Benzamides; D010879:Piperazines; D010936:Plant Extracts; D011725:Pyridines; D012702:Serotonin Antagonists; D012997:Solvents; D044282:Receptor, Serotonin, 5-HT1A; C103477:3-(3-(dimethylamino)propyl)-4-hydroxy-N-(4-(4-pyridinyl)phenyl)benzamide; D008752:Methylene Chloride; C090413:N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide; D007650:Ketanserin; D010869:Pindolol