title: Diffusible signal factor-dependent cell-cell signaling and virulence in the nosocomial pathogen Stenotrophomonas maltophilia.
abstract: The genome of Stenotrophomonas maltophilia encodes a cell-cell signaling system that is highly related to the diffusible signal factor (DSF)-dependent system of the phytopathogen Xanthomonas campestris. Here we show that in S. maltophilia, DSF signaling controls factors contributing to the virulence and antibiotic resistance of this important nosocomial pathogen.
authors.affiliation: BIOMERIT Research Centre, Department of Microbiology, BioSciences Institute, National University of Ireland, Cork, Ireland.
authors.forename: Yvonne
authors.initials: Y
authors.lastname: Fouhy
authors.forename: Karl
authors.initials: K
authors.lastname: Scanlon
authors.forename: Katherine
authors.initials: K
authors.lastname: Schouest
authors.forename: Charles
authors.initials: C
authors.lastname: Spillane
authors.forename: Lisa
authors.initials: L
authors.lastname: Crossman
authors.forename: Matthew B
authors.initials: MB
authors.lastname: Avison
authors.forename: Robert P
authors.initials: RP
authors.lastname: Ryan
authors.forename: J Maxwell
authors.initials: JM
authors.lastname: Dow
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001426:Bacterial Proteins / Q000235:genetics* / Q000378:metabolism / Q000502:physiology; D003428:Cross Infection / Q000382:microbiology; D024881:Drug Resistance, Bacterial / Q000235:genetics; D015964:Gene Expression Regulation, Bacterial; D005798:Genes, Bacterial; D006801:Humans; D019216:Metals, Heavy / Q000494:pharmacology; D005810:Multigene Family; D009154:Mutation; D015398:Signal Transduction / Q000235:genetics* / Q000502:physiology; D020615:Stenotrophomonas maltophilia / Q000187:drug effects / Q000235:genetics* / Q000472:pathogenicity; D014774:Virulence / Q000235:genetics; D016959:Xanthomonas campestris / Q000235:genetics
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D019216:Metals, Heavy