title: Meeting the needs of monitoring in tissue engineering.
abstract: Tissue engineering is a rapidly growing field that aims to develop biological substitutes that restore, maintain or improve tissue function. The focus of research to date has been the underlying biology required for tissue-engineered therapies. However, as tissue-engineered products reach the marketplace, there is a pressing need for an improved understanding of the engineering and economic issues associated with them. This is motivated by the lack of commercial viability of many of the initial therapies that have been produced. It has been suggested in the literature that this is partly due to poor process and system design in tissue production, as well as a lack of process monitoring and control. This review argues that principles of design, measurement and process monitoring from the physical sciences are needed to move tissue engineering forward, and that much of the technology needed to realize this is already available.
authors.affiliation: Applied Optics Group, School of Electrical and Electronic Engineering, University of Nottingham, Nottingham, UK.
authors.forename: Melissa L
authors.initials: ML
authors.lastname: Mather
authors.forename: Stephen P
authors.initials: SP
authors.lastname: Morgan
authors.forename: John A
authors.initials: JA
authors.lastname: Crowe
mesh_terms: D021522:Bioartificial Organs; D019149:Bioreactors; D018929:Cell Culture Techniques / Q000295:instrumentation / Q000379:methods; D008853:Microscopy; D044968:Regenerative Medicine; D013057:Spectrum Analysis; D023822:Tissue Engineering / Q000295:instrumentation / Q000379:methods*