title: [Influence of DNA damage on fertilizing capacity of spermatozoa].
abstract: DNA damage in the male germ line cells is correlated with male infertility. Nuclear DNA damage in mature sperm includes single strand nicks and double strand breaks that can arise as a consequence of errors in chromatin rearrangement during spermiogenesis, abortive apoptosis, and oxidative stress. Methods of assisted reproduction may be connected with a risk of the using of sperm with impaired DNA integrity that can lead to spontaneous abortion or delivery of a child with congenital abnormalities.
authors.affiliation: Katedra i Zakład Biochemii i Biologii Molekularnej Akademii Medycznej im. K. Marcinkowskiego w Poznaniu.
authors.forename: Jacek
authors.initials: J
authors.lastname: Sikora
authors.forename: Bartosz
authors.initials: B
authors.lastname: Kempisty
authors.forename: Piotr
authors.initials: P
authors.lastname: Jedrzejczak
authors.forename: Paweł P
authors.initials: PP
authors.lastname: Jagodziński
mesh_terms: D000022:Abortion, Spontaneous / Q000209:etiology; D000818:Animals; D017209:Apoptosis; D002648:Child; D004249:DNA Damage / Q000502:physiology; D053938:DNA Fragmentation; D005260:Female; D006801:Humans; D007248:Infertility, Male / Q000150:complications / Q000235:genetics*; D008297:Male; D011247:Pregnancy; D017382:Reactive Oxygen Species / Q000378:metabolism; D020554:Sperm Injections, Intracytoplasmic / Q000379:methods; D013094:Spermatozoa / Q000473:pathology / Q000502:physiology / Q000648:ultrastructure*
chemical_list: D017382:Reactive Oxygen Species