Pathophysiology of white-tailed deer vaccinated with porcine zona pellucida immunocontraceptive.
White-tailed deer (n=14 treated, n=7 control) were examined postmortem to identify any possible pathophysiology resulting from PZP immunocontraception vaccination. Deer were treated twice in 1997; given a booster in 1998, with six being revaccinated in September 2000. Granulomas were found at injection sites of most deer, even 2 years post-treatment. Eosinophilic oophoritis occurred in 6 of 8 (75%) deer vaccinated in 1998, and 3 of 6 (50%) revaccinated in 2000. The 2000 revaccinates without oophoritis, had significantly fewer normal secondary follicles than control females (P=0.03), and deer in the 1998 treatment group (P=0.04). PZP immunocontraceptive vaccine elicited ovarian pathologies in deer similar to those observed in other species.
Curtis
Paul D
PD
Department of Natural Resources, Cornell University, Ithaca, NY 14853, USA. pdc1@cornell.edu
Richmond
Milo E
ME
Miller
Lowell A
LA
Quimby
Fred W
FW
D000818:Animals; D001853:Bone Marrow / Q000378:metabolism; D003269:Contraception, Immunologic / Q000662:veterinary*; D003670:Deer; D004804:Eosinophils / Q000502:physiology; D005260:Female; D009869:Oophoritis / Q000209:etiology; D009929:Organ Size; D006080:Ovarian Follicle / Q000166:cytology; D010053:Ovary / Q000473:pathology*; D013552:Swine; D014611:Vaccination; D022642:Vaccines, Contraceptive / Q000276:immunology*; D015044:Zona Pellucida / Q000276:immunology*
D022642:Vaccines, Contraceptive