title: Roles of CD147 on T lymphocytes activation and MMP-9 secretion in systemic lupus erythematosus.
abstract: The cellular and molecular mechanisms involved in many abnormalities described in Systemic Lupus Erythematosus (SLE) are still unclear. Some of these abnormalities referred to the hyperactivation of T lymphocytes and the enhanced secretion of MMP-9 by peripheral blood mononuclear cells (PBMCs). Therefore, in this paper we investigated the potential role of CD147 molecule in these abnormalities. Our results demonstrated that CD147 molecule is overexpressed on CD3+T lymphocytes from SLE patients when compared with CD3+T lymphocytes from healthy donors. Monoclonal anti-CD147 antibodies, MEM-M6/1 clone, were able to inhibit protein tyrosine phosphorylation only in CD3 x CD28 costimulated T lymphocytes from SLE patients. However, this monoclonal antibody was unable to inhibit the enhanced activity of MMP-9 secreted by SLE PBMCs.
authors.affiliation: Centre for Advanced Studies, Cellular Receptors Laboratory, Cantacuzino National Institute of Research and Development for Microbiology and Immunology, Splaiul Independentei 103, Bucharest 050096, Romania.
authors.forename: Gina
authors.initials: G
authors.lastname: Pistol
authors.forename: Cristiana
authors.initials: C
authors.lastname: Matache
authors.forename: Ana
authors.initials: A
authors.lastname: Calugaru
authors.forename: Crina
authors.initials: C
authors.lastname: Stavaru
authors.forename: Stefanita
authors.initials: S
authors.lastname: Tanaseanu
authors.forename: Ruxandra
authors.initials: R
authors.lastname: Ionescu
authors.forename: Sergiu
authors.initials: S
authors.lastname: Dumitrache
authors.forename: Maria
authors.initials: M
authors.lastname: Stefanescu
mesh_terms: D051926:Basigin / Q000097:blood*; D017252:CD3 Complex / Q000276:immunology / Q000378:metabolism; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000201:enzymology / Q000378:metabolism; D008180:Lupus Erythematosus, Systemic / Q000097:blood* / Q000235:genetics / Q000276:immunology*; D008213:Lymphocyte Activation; D020780:Matrix Metalloproteinase 9 / Q000097:blood* / Q000235:genetics; D016176:T-Lymphocyte Subsets / Q000378:metabolism; D013601:T-Lymphocytes / Q000378:metabolism*
chemical_list: D017252:CD3 Complex; D051926:Basigin; D020780:Matrix Metalloproteinase 9