Estimates of heritable and environmental components of familial breast cancer using family history information.
Using the Swedish Family-Cancer Database, the increased risk of breast cancer in women with relatives with the disease did not vary with paternal/maternal lineage. Familial breast cancer heritable component was 73% and the environmental proportion 27%. Familial aggregation of breast cancer in women below age 51 years is mainly due to heritable causes.
Couto
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Department of Neurobiology, Care Sciences and Society, Karolinska Institute, CeFAM, Alfred Nobels Allé 12, Plan 5, 141 83 Huddinge, Sweden. Elisabeth.Couto@ki.se
Hemminki
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D000293:Adolescent; D000328:Adult; D001943:Breast Neoplasms / Q000209:etiology* / Q000235:genetics*; D002277:Carcinoma / Q000209:etiology* / Q000235:genetics*; D004777:Environment; D005192:Family Health; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008875:Middle Aged; D012042:Registries; D012307:Risk Factors