title: Effect of tamoxifen on arterial microvascular anastomosis.
abstract: Breast reconstruction after cancer treatment is based on the circulation of pedicle and microvascular flaps. This article aimed to verify the effect of tamoxifen (TMX) pretreatment in arterial anastomosis in rats. Twenty female Wistar rats were equally divided into two groups. TMX (0.3 mg/kg) was administered to the experimental group for 2 weeks orally. After this period, the right femoral artery was sectioned and a terminoterminal anastomosis performed. The same procedure was done in the control group, except that the animals received the vehicle without TMX. One week later, the femoral arteries were inspected for flow through the anastomosis, and the vessel near it was sent to light microscopic examination. It was observed mild vasculite in both groups. The intimal thickness and total vessel wall in the TMX-treated group was significantly higher. A real thrombotic effect upon the arterial vascular anastomosis was not observed, eventhough, TMX induced intimal hyperplasia.
authors.affiliation: Division of Plastic Surgery, Department of Surgery, Federal University of Ceara, Fortaleza, Brazil. breno_gpp@yahoo.com.br
authors.forename: Breno Bezerra Gomes
authors.initials: BB
authors.lastname: De Pinho Pessoa
authors.forename: Bruno Bezerra
authors.initials: BB
authors.lastname: Menezes Cavalcante
authors.forename: Munique Pinheiro
authors.initials: MP
authors.lastname: Maia
authors.forename: Haroldo H
authors.initials: HH
authors.lastname: Ribeiro Filho
authors.forename: Marcia Kiyomi
authors.initials: MK
authors.lastname: Koike
authors.forename: Salustiano Gomes
authors.initials: SG
authors.lastname: De Pinho Pessoa
authors.forename: Luiz Gonzaga
authors.initials: LG
authors.lastname: Porto Pinheiro
authors.forename: Edna Frasson De Souza
authors.initials: EF
authors.lastname: Montero
mesh_terms: D000714:Anastomosis, Surgical; D000818:Animals; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D005260:Female; D005263:Femoral Artery / Q000187:drug effects* / Q000473:pathology / Q000601:surgery; D008866:Microsurgery; D051381:Rats; D017208:Rats, Wistar; D013629:Tamoxifen / Q000627:therapeutic use*; D013927:Thrombosis / Q000209:etiology / Q000517:prevention & control; D014654:Vascular Patency / Q000187:drug effects*
chemical_list: D018931:Antineoplastic Agents, Hormonal; D013629:Tamoxifen