title: Application and drying of protein drug microdroplets on solid surfaces.
abstract: A new method to apply small amounts of protein drug solutions in the form of microdroplets to surfaces and to dry them is presented. A robotic dispensing system was used to divide concentrated aqueous protein solutions into microdroplets 20-mL and to place them onto various solid surfaces in a predetermined manner. Afterward, vacuum drying was applied to reduce the residual moisture of the protein/excipient matrix. Optionally, spray coating of the dry microdroplet patterns was carried out to achieve controlled release. Process parameters were studied and optimized for residual moisture, protein stability, and long-term storage stability.
authors.affiliation: Department of Pharmacy, Ludwig-Maximilians-Universität, Munich, Germany. a.stabenau@gmx.de
authors.forename: Anke
authors.initials: A
authors.lastname: Stabenau
authors.forename: Gerhard
authors.initials: G
authors.lastname: Winter
mesh_terms: D000279:Administration, Cutaneous; D002626:Chemistry, Pharmaceutical; D003890:Desiccation; D004337:Drug Carriers; D016503:Drug Delivery Systems; D004355:Drug Stability; D004356:Drug Storage; D004563:Electrochemistry; D004921:Erythropoietin / Q000008:administration & dosage / Q000737:chemistry; D005079:Excipients; D005612:Freeze Drying; D053758:Nanoparticles; D011506:Proteins / Q000008:administration & dosage / Q000737:chemistry*; D011994:Recombinant Proteins; D012371:Robotics; D013499:Surface Properties
chemical_list: D004337:Drug Carriers; D005079:Excipients; D011506:Proteins; D011994:Recombinant Proteins; D004921:Erythropoietin