From broken to old: DNA damage, IGF1 endocrine suppression and aging.
Two recent reports provide new information on how DNA damage may generate progeroid changes at the cell and organismal level by suppressing growth hormone (GH)/insulin-like growth factor 1 (IGF1) endocrine signaling. This endocrine signaling pathway is of particular interest as it is a key regulator of metabolism and longevity in many organisms.
Monnat
Raymond J
RJ
Department of Pathology, University of Washington, Box 357705 Seattle, WA 98195-7705, United States. monnat@u.washington.edu
D000375:Aging; D000818:Animals; D004249:DNA Damage; D004702:Endocrine Glands / Q000378:metabolism*; D013006:Growth Hormone / Q000378:metabolism*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D008136:Longevity; D011371:Progeria; D015398:Signal Transduction
D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone