Studies on preparation and absolute bioavailability of a self-emulsifying system containing puerarin.
The purpose of the study was to develop an optimum formulation of self-emulsifying drug delivery systems (SEDDS) containing puerarin and to evaluate its absolute bioavailability. Using oleic acid as oil, Tween-80 as surfactant and propylene glycol as cosurfactant, a series of mixtures comprising oleic acid, propylene glycol and Tween 80 were prepared and their self-emulsifying properties were studied. Pseudo-ternary phase diagrams were constructed to identify the efficient self-emulsification region and particle sizes of the resultant emulsions were determined using a laser diffraction sizer. From these studies, an optimized formulation consisting of oil (17.5%), Tween-80 (34.5%) and cosurfactant (34.5%) was selected and its absolute bioavailability in beagle dogs after oral administration was about 24.8%. The data suggest the use of SEDDS to provide a potential way of puerarin administered orally.
Quan
Dong-qin
DQ
Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, China. wzbqdq@sohu.com
Xu
Gui-xia
GX
Wu
Xiang-gen
XG
D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics*; D000818:Animals; D001682:Biological Availability; D002626:Chemistry, Pharmaceutical; D004285:Dogs; D016503:Drug Delivery Systems; D004655:Emulsions; D007529:Isoflavones / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics*; D009821:Oils; D012995:Solubility; D013501:Surface-Active Agents
D000319:Adrenergic beta-Antagonists; D004655:Emulsions; D007529:Isoflavones; D009821:Oils; D013501:Surface-Active Agents; C033607:puerarin