title: Laparoscopic cholecystectomy only could be an appropriate treatment for selected clinical R0 gallbladder carcinoma.
abstract: BACKGROUND
  Laparoscopic cholecystectomy (LC) for gallbladder carcinoma still is controversial except for the early stages of gallbladder carcinoma (Tis). This study was designed to evaluate and revisit the role of LC in treating gallbladder carcinoma.
  
  
  METHODS
  Available medical records of patients with surgeries for gallbladder carcinoma were retrospectively investigated from August 1992 to February 2005.
  
  
  RESULTS
  Among 219 patients treated for gallbladder carcinoma, 57 (26%) underwent LC. A total of 16 patients (28.1%) underwent subsequent radical cholecystectomy (LC-RC), and 41 (71.9%) were only followed up without radical surgery (LC). Tis was found in 11 patients (19.3%), T1a in 3 patients (5.3%), T1b in 8 patients (14%), T2 in 19 patients (33.3%), and T3 in 16 patients (28.1%). The findings showed R0 in 14 cases of the radical cholecystectomy group, and clinical R0 was noted in 30 cases of the LC-only group. No survival differences were noted between LC and LC-RC (p = 0.2575), especially in the case of T2 lesions (p = 0.6274), nor between the R0 and clinical R0 (p = 0.5839). However, significant survival differences were noted between the R2 and R0 groups, and between R2 and clinical R0, respectively (p < 0.001).
  
  
  CONCLUSIONS
  The findings show that LC could be appropriate treatment for gallbladder carcinoma only in selected cases of clinical R0 lesions.
authors.affiliation: Department of Surgery, Yonsei University College of Medicine, 134 Shinchon-dong, Seodaemun-gu, Seoul, Korea. cmkang@yumc.yonsei.ac.kr
authors.forename: C M
authors.initials: CM
authors.lastname: Kang
authors.forename: G H
authors.initials: GH
authors.lastname: Choi
authors.forename: S H
authors.initials: SH
authors.lastname: Park
authors.forename: K S
authors.initials: KS
authors.lastname: Kim
authors.forename: J S
authors.initials: JS
authors.lastname: Choi
authors.forename: W J
authors.initials: WJ
authors.lastname: Lee
authors.forename: B R
authors.initials: BR
authors.lastname: Kim
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D017081:Cholecystectomy, Laparoscopic; D005260:Female; D005706:Gallbladder Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015996:Survival Rate