title: Synthesis and SAR studies of potent imidazopyridine anticoccidial agents.
abstract: Diaryl imidazo[1,2-a]pyridine derivatives, such as 6a and 7i, have been synthesized and found to be potent inhibitors of parasite PKG activity. The most potent compounds are the 7-isopropylaminomethyl analog 6a and 2-isopropylamino analog 7i. These compounds are also fully active in in vivo assay as anticoccidial agents at 25 ppm in feed.
authors.affiliation: Merck Research Laboratories, Department of Medicinal Chemistry, Merck and Co., Inc., PO Box 2000, Rahway, NJ 07065, USA. gui-bai_liang@merck.com <gui-bai_liang@merck.com>
authors.forename: Gui-Bai
authors.initials: GB
authors.lastname: Liang
authors.forename: Xiaoxia
authors.initials: X
authors.lastname: Qian
authors.forename: Dennis
authors.initials: D
authors.lastname: Feng
authors.forename: Michael
authors.initials: M
authors.lastname: Fisher
authors.forename: Christine M
authors.initials: CM
authors.lastname: Brown
authors.forename: Anne
authors.initials: A
authors.lastname: Gurnett
authors.forename: Penny Sue
authors.initials: PS
authors.lastname: Leavitt
authors.forename: Paul A
authors.initials: PA
authors.lastname: Liberator
authors.forename: Andrew S
authors.initials: AS
authors.lastname: Misura
authors.forename: Tamas
authors.initials: T
authors.lastname: Tamas
authors.forename: Dennis M
authors.initials: DM
authors.lastname: Schmatz
authors.forename: Matthew
authors.initials: M
authors.lastname: Wyvratt
authors.forename: Tesfaye
authors.initials: T
authors.lastname: Biftu
mesh_terms: D000818:Animals; D002626:Chemistry, Pharmaceutical / Q000379:methods; D003048:Coccidiosis / Q000188:drug therapy*; D003049:Coccidiostats / Q000737:chemistry / Q000494:pharmacology*; D017869:Cyclic GMP-Dependent Protein Kinases / Q000378:metabolism; D015195:Drug Design; D016786:Eimeria tenella; D007093:Imidazoles / Q000737:chemistry*; D008956:Models, Chemical; D047428:Protein Kinase Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D011725:Pyridines / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D003049:Coccidiostats; D007093:Imidazoles; D047428:Protein Kinase Inhibitors; D011725:Pyridines; D017869:Cyclic GMP-Dependent Protein Kinases