Nuclear microenvironment in cancer diagnosis and treatment.
The nuclear architecture plays an important role in the temporal and spatial control of complex functional processes within the nucleus. Alterations in nuclear structures are characteristic of cancer cells and the mechanisms underlying these perturbations may directly contribute to tumor development and progression. In this review, we will highlight aspects of the nuclear microenvironment that are perturbed during tumorigenesis and discuss how a greater understanding of the role of nuclear structure in the control of gene expression can provide new options for cancer diagnosis and treatment.
Pezo
Rossanna C
RC
Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York, USA.
Singer
Robert H
RH
D002451:Cell Compartmentation; D002467:Cell Nucleus / Q000235:genetics / Q000473:pathology*; D022003:Cell Nucleus Structures / Q000473:pathology; D006801:Humans; D007399:Interphase; D009369:Neoplasms / Q000175:diagnosis* / Q000628:therapy*; D014158:Transcription, Genetic