title: Benign parathyroid adenoma presenting with unusual parathyroid crisis, anemia and myelofibrosis.
abstract: Although the clinical symptoms of patients with benign parathyroid adenoma are usually nonspecific and benign, a malignant presentation of the benign disease may sometimes occur. Here, we report a case of a 58-year-old woman who presented with aggravated sacrum pain, general malaise, and polydipsia. Initial laboratory findings revealed hypercalcemia, normocytic anemia, and impaired renal function. Acute hypercalcemic crisis manifested and primary hyperparathyroidism was diagnosed together with myelofibrosis on account of the result of bone marrow biopsy. Excision of a parathyroid adenoma was performed, and the anemia and bone marker regressed later. These findings suggested that benign parathyroid adenoma may mimic the clinical presentation of parathyroid carcinoma, releasing excess parathyroid hormone and resulting in hyperparathyroid crisis. In addition, primary hyperparathyroidism can be associated with anemia and myelofibrosis.
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine, Taoyuan Veterans Hospital, Taoyuan, Taiwan.
authors.forename: Shu-Chuan
authors.initials: SC
authors.lastname: Huang
authors.forename: Vin-Cent
authors.initials: VC
authors.lastname: Wu
authors.forename: Guan
authors.initials: G
authors.lastname: Chou
authors.forename: Tzu-Yu
authors.initials: TY
authors.lastname: Huang
authors.forename: Shih-Yi
authors.initials: SY
authors.lastname: Lin
authors.forename: Wayne Huey-Herng
authors.initials: WH
authors.lastname: Sheu
mesh_terms: D000236:Adenoma / Q000150:complications*; D000740:Anemia / Q000209:etiology*; D005260:Female; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology*; D049950:Hyperparathyroidism, Primary / Q000209:etiology*; D008875:Middle Aged; D010282:Parathyroid Neoplasms / Q000150:complications*; D055728:Primary Myelofibrosis / Q000209:etiology*