Serum antibodies to the pneumococcal surface proteins PhtB and PhtE in Finnish infants and adults.
We examined naturally acquired antibodies to pneumococcal vaccine candidate proteins PhtB and PhtE in children during their first 2 years of life. Prior culture-confirmed pneumococcal exposure was shown to induce the development of anti-PhtB and -PhtE antibodies. The anti-PhtB or -PhtE antibody concentrations were not significantly associated with a decreased risk of subsequent pneumococcal acute otitis media.
Holmlund
Emma
E
The National Public Health Institute, Helsinki, Finland.
Simell
Birgit
B
Jaakkola
Teija
T
Lahdenkari
Mika
M
Hamel
Josée
J
Brodeur
Bernard
B
Kilpi
Terhi
T
Käyhty
Helena
H
D000208:Acute Disease; D000328:Adult; D000367:Age Factors; D000907:Antibodies, Bacterial / Q000097:blood*; D001426:Bacterial Proteins / Q000276:immunology*; D006801:Humans; D006867:Hydrolases / Q000276:immunology*; D007223:Infant; D008565:Membrane Proteins / Q000276:immunology; D010033:Otitis Media / Q000209:etiology; D013296:Streptococcus pneumoniae / Q000276:immunology*
D000907:Antibodies, Bacterial; D001426:Bacterial Proteins; D008565:Membrane Proteins; C097552:histidine triad protein; D006867:Hydrolases