title: Reactive peripheral blood plasmacytosis in a patient with acute hepatitis A.
abstract: Reactive plasmacytosis is a transient expansion of plasma cell progenitors and precursors. This rare condition has been reported to occur mainly in infections and tumors. We describe a case of acute hepatitis A presenting with marked peripheral blood plasmacytosis. Plasma cells made up 27.5% of the mononuclear cells and had the immunophenotype CD10-CD19+CD20-CD21-CD23-CD34-CD38++HLA-DR+. Although the level of interleukin 6 was not increased, the presence of activated T-cells with an inverted CD4/CD8 ratio and high levels of soluble interleukin 2 receptor and neopterin indicated a marked immune response to acute hepatitis A. The patient's plasma cells had almost disappeared from the blood by hospital day 16. This report may represent the first described case of reactive peripheral blood plasmacytosis in acute hepatitis A.
authors.affiliation: Department of Pediatrics, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan. taizo@ped.m.kanazawa-u.ac.jp
authors.forename: Taizo
authors.initials: T
authors.lastname: Wada
authors.forename: Hideaki
authors.initials: H
authors.lastname: Maeba
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Ikawa
authors.forename: Yoko
authors.initials: Y
authors.lastname: Hashida
authors.forename: Akiko
authors.initials: A
authors.lastname: Okumura
authors.forename: Fumie
authors.initials: F
authors.lastname: Shibata
authors.forename: Yumi
authors.initials: Y
authors.lastname: Tone
authors.forename: Masayuki
authors.initials: M
authors.lastname: Inoue
authors.forename: Shoichi
authors.initials: S
authors.lastname: Koizumi
authors.forename: Hajime
authors.initials: H
authors.lastname: Takatori
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Sakai
authors.forename: Shuichi
authors.initials: S
authors.lastname: Kaneko
authors.forename: Akihiro
authors.initials: A
authors.lastname: Yachie
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D005434:Flow Cytometry; D006506:Hepatitis A / Q000097:blood*; D006801:Humans; D007958:Leukocyte Count / Q000145:classification; D008297:Male; D010950:Plasma Cells / Q000821:virology*