title: Risk factors of distress in Alzheimer's patients.
abstract: BACKGROUND
  Distress of Alzheimer's disease (AD) contribute significantly to decreased quality of life, increased morbidity, higher levels of caregiver distress, and the decision to institutionalise a patient. However, the risk factors of distress in AD patients have not been thoroughly discussed. The aim of this study was to identify the risk factors of distress in AD patients.
  
  
  METHODS
  A large randomised controlled clinical trial on AD was analysed in this study. Both linear regression and decision tree models were used to identify the factors of distress in AD patients.
  
  
  RESULTS
  The following variables were recognised as risk factors for AD patient's distress: Care recipients often visit physicians or have medical examinations; Care recipients take medicines that affect the central nervous system or stomach; Care recipients seldom visit nurses; Caregivers have chronic disease or cancer; Caregiver experience distress, feel lonely, or have an unsatisfactory relationship with patients. In addition, caregiver's smoking and drinking were found to correlate negatively with AD patient's distress.
  
  
  CONCLUSIONS
  Multiple factors influence the distress of Alzheimer's patients, including patient's examination and medication, patient-caregiver relationships, caregiver's psychological and physical status, and the use of nursing services. These factors should be targeted when designing prevention and intervention strategies.
authors.affiliation: Department of Neurology, The Shanghai First People's Hospital, Shanghai Jiaotong University, Shanghai, PR China. zhou_xiaolin@163.com
authors.forename: Xiaolin
authors.initials: X
authors.lastname: Zhou
authors.forename: Jie
authors.initials: J
authors.lastname: Xu
authors.forename: Yongbo
authors.initials: Y
authors.lastname: Zhao
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000150:complications / Q000523:psychology*; D017028:Caregivers / Q000523:psychology; D017281:Cost of Illness; D003657:Decision Making; D003663:Decision Trees; D005195:Family Relations; D005260:Female; D006701:Home Nursing / Q000523:psychology*; D006801:Humans; D016014:Linear Models; D008297:Male; D009819:Office Visits / Q000706:statistics & numerical data; D011369:Professional-Patient Relations; D011788:Quality of Life / Q000523:psychology; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D013315:Stress, Psychological / Q000209:etiology*; D014481:United States