Role of infrainguinal angioplasty in the treatment of critical limb ischaemia.
OBJECTIVE
To review the published papers reporting on the use of infrainguinal angioplasty in the treatment of critical limb ischaemia (CLI).


METHODS
A MEDLINE (1966-2005) and Cochrane library search for articles relating to the use of infrainguinal angioplasty in the treatment of CLI.


RESULTS
Recent papers reporting on the results of infrainguinal angioplasty as treatment for CLI patients show excellent limb salvage rates regardless of the patency rates. The Cochrane Database of systematic reviews has accepted two prospective randomised trials comparing bypass operations and angioplasty among CLI patients. Pooling both trials showed no overall significant difference in amputation rates between the surgery and PTA groups. A multicentre, randomised controlled trial, the BASIL (Bypass versus Angioplasty in Severe Ischaemia of the Leg) trial showed that in the medium term (after six months), the outcomes after angioplasty or surgery among CLI patients did not differ significantly with respect to amputation-free survival, all-cause mortality and quality of life.


CONCLUSIONS
Infrainguinal PTA is feasible in CLI patients. Data from the BASIL trial show the similar ability of bypass surgery and balloon angioplasty in preserving both life and limb in short term. These results are, however, not applicable for the majority of CLI patients as only 15% (70/456) of the patients with severe limb ischaemia were considered candidates for the trial.
Eskelinen
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Department of Vascular Surgery, Helsinki University Central Hospital, Helsinki, Finland. elina.eskelinen@fimnet.fi
Lepäntalo
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D000800:Angioplasty, Balloon / Q000379:methods*; D001157:Arterial Occlusive Diseases / Q000628:therapy*; D005263:Femoral Artery; D006801:Humans; D012720:Severity of Illness Index; D016896:Treatment Outcome