title: Transpulmonary dilution-derived extravascular lung water as a measure of lung edema.
abstract: OBJECTIVE
  This review highlights current insights concerning the (measurement of) extravascular lung water as an index of pulmonary edema, by transpulmonary dilution techniques. The focus is on the applicability of the technique at the bedside in monitoring critically ill patients.
  
  
  RESULTS
  Several (animal) studies have been performed to validate the technique by postmortem gravimetry in different conditions. Moreover, recent clinical data emphasize the utility of the thermodilution-derived extravascular lung water, its contribution to the clinical manifestations of acute lung injury/acute respiratory distress syndrome, its response to treatment aimed at edema prevention or resolution, and as a prognostic parameter.
  
  
  CONCLUSIONS
  The thermodilution-derived extravascular lung water is a useful adjunct to assess lung vascular injury, cardiogenic edema and overhydration and to guide treatment in critically ill patients. The effects on morbidity and mortality of this approach need to be studied further.
authors.affiliation: Department of Intensive Care, VU University Medical Center, Amsterdam, The Netherlands.
authors.forename: Saheed
authors.initials: S
authors.lastname: Khan
authors.forename: Ronald J
authors.initials: RJ
authors.lastname: Trof
authors.forename: A B Johan
authors.initials: AB
authors.lastname: Groeneveld
mesh_terms: D000818:Animals; D015633:Extravascular Lung Water; D006801:Humans; D011651:Pulmonary Artery; D011654:Pulmonary Edema / Q000175:diagnosis* / Q000473:pathology; D013815:Thermodilution / Q000379:methods