[Effect of mannitol on vasoactive substances].
OBJECTIVE
To observe the changes of vasoactive substances in rabbits administered with mannitol at different dosages and to investigate the mechanism of acute renal failure (ARF) induced by massive mannitol administration.


METHODS
Eighteen healthy male New Zealand rabbits were randomly divided into 3 groups: a minor mannitol group (n=6, mannitol 8 g/kg within 2 hours), a control group (n=6, saline of the same volume), and a massive mannitol group with free water taking (n=6, mannitol 40~60 g/kg within 3 days). The changes of renin, angiotensin-I (ang-I), angiotensin-II (ang-II), endothelin (ET), and atrial natriuretic factor(ANF) in the serum were observed.


RESULTS
No significant changes in the renin, ang-I, ang-II, ET, and ANF in the serum were found between the minor mannitol group and the saline control group (P> 0.05). In the massive mannitol group with free water taking, renin, ang-I, and ang-II in the serum increased significantly compared with the other 2 groups; ET in the serum decreased significantly compared with the saline control group (P< 0.05); no significant changes in the ANF in the serum were found compared with the other 2 groups(P> 0.05).


CONCLUSIONS
ARF induced by massive mannitol administration is associated with a significant change of vasoactive substances.
Zhu
Xiao-Ping
XP
Department of Nephrology, Second Xiangya Hospital, Central South University, Changsha, China. zhuxiaoping0508@hotmail.com
Luo
Ji-An
JA
Liu
Fu-You
FY
Peng
You-Ming
YM
D058186:Acute Kidney Injury / Q000097:blood* / Q000139:chemically induced / Q000503:physiopathology; D000809:Angiotensins / Q000097:blood*; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000097:blood*; D004305:Dose-Response Relationship, Drug; D016232:Endothelins / Q000097:blood*; D008297:Male; D008353:Mannitol / Q000008:administration & dosage / Q000633:toxicity*; D011817:Rabbits; D011897:Random Allocation; D012079:Renal Circulation / Q000187:drug effects; D012084:Renin-Angiotensin System / Q000187:drug effects
D000809:Angiotensins; D016232:Endothelins; D008353:Mannitol; D009320:Atrial Natriuretic Factor