title: [Adenomatous polyposis of the gallbladder and Gardner's syndrome. A rare association].
abstract: We report one case of adenomatous polyposis of the gallbladder in a 57 year-old woman with Gardner's syndrome presenting with cholangitis. On gross examination the gallbladder contained two calculi and numerous flat or polypoid adenomas less than 1 cm in size. On microscopic examination, the adenomas showed low and high grade intraepithelial neoplasia. Only 10 cases of gallbladder adenomas have been reported in the literature in patients presenting with familial adenomatous polyposis (FAP). Cholecystectomy is usually performed for cholecystitis or cholangitis. These adenomatous gallbladder lesions are discovered late, often when the patient is older than 40. Pathogenesis of gallbladder adenomas is still unclear. It is difficult to assess the risk of malignancy: only 6 cases of gallbladder adenocarcinomas have been reported in patients with FAP.
authors.affiliation: Service d'Anatomie Pathologique, CHU Amiens, Place Victor Pauchet, Amiens, France. Brevet.marie@chu-amiens.fr
authors.forename: Marie
authors.initials: M
authors.lastname: Brevet
authors.forename: Olivier
authors.initials: O
authors.lastname: Brehant
authors.forename: Frédéric
authors.initials: F
authors.lastname: Dumont
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Regimbeau
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Dupas
authors.forename: Denis
authors.initials: D
authors.lastname: Chatelain
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology; D018256:Adenomatous Polyps / Q000150:complications* / Q000473:pathology / Q000601:surgery; D000328:Adult; D000367:Age Factors; D000368:Aged; D002763:Cholecystectomy; D005260:Female; D005500:Follow-Up Studies; D005704:Gallbladder / Q000473:pathology; D005706:Gallbladder Neoplasms / Q000150:complications* / Q000473:pathology / Q000601:surgery; D005736:Gardner Syndrome / Q000150:complications*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013997:Time Factors