Efficacy of fluoroquinolones against Leptospira interrogans in a hamster model.
Ciprofloxacin, gatifloxacin, and levofloxacin were evaluated for their abilities to prevent mortality in hamsters infected with a lethal inoculum of Leptospira interrogans serovar Portlandvere. Each agent produced a statistically significant survival advantage compared to no treatment and demonstrated survival similar to that seen with doxycycline therapy.
Griffith
Matthew E
ME
Infectious Disease Service, MCHE-MDI, Brooke Army Medical Center, 3851 Roger Brooke Drive, Fort Sam Houston, TX 78234, USA. matthew.griffith@amedd.army.mil
Moon
James E
JE
Johnson
Erica N
EN
Clark
Kyra P
KP
Hawley
Joshua S
JS
Hospenthal
Duane R
DR
Murray
Clinton K
CK
D000208:Acute Disease; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002939:Ciprofloxacin / Q000494:pharmacology; D006224:Cricetinae; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004318:Doxycycline / Q000494:pharmacology; D005260:Female; D024841:Fluoroquinolones / Q000494:pharmacology*; D000077734:Gatifloxacin; D007274:Injections, Intraperitoneal; D007921:Leptospira interrogans / Q000145:classification / Q000187:drug effects*; D007922:Leptospirosis / Q000188:drug therapy* / Q000401:mortality; D064704:Levofloxacin; D008647:Mesocricetus; D015242:Ofloxacin / Q000494:pharmacology; D012703:Serotyping; D016019:Survival Analysis
D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D002939:Ciprofloxacin; D064704:Levofloxacin; D015242:Ofloxacin; D000077734:Gatifloxacin; D004318:Doxycycline