The role of high-risk HPV-DNA testing in the male sexual partners of women with HPV-induced lesions.
OBJECTIVE
The objectives were to assess the prevalence of high-risk HPV in the male sexual partners of women with HPV-induced lesions, and correlate it with biopsies guided by peniscopy.


METHODS
Fifty-four asymptomatic male sexual partners of women with low-grade squamous intra-epithelial lesions (LSIL) associated with high-risk HPV were examined between April 2003 and June 2005. The DNA-HPV was tested using a second-generation hybrid capture technique in scraped penile samples. Peniscopy identified acetowhite lesions leading to biopsy.


RESULTS
High-risk HPV was present in 25.9% (14 out of 54) of the cases. Peniscopy led to 13 biopsies (24.07%), which resulted in two cases of condyloma, two cases of intra-epithelial neoplasia (PIN) I, one case of PIN II, and eight cases of normal tissue. The high-risk HPV test demonstrated 80% sensitivity, 100% specificity, 100% positive predictive value, and 88.9% negative predictive value for the identification of penile lesions. There was a greater chance of finding HPV lesions in the biopsy in the positive cases of high-risk HPV with abnormal peniscopy (p=0.007); OR=51 (CI 1.7-1527.1).


CONCLUSIONS
Among asymptomatic male sexual partners of women with low-grade intra-epithelial squamous lesions, those infected by high-risk HPV have a higher chance of having abnormal penile tissue compared with male partners without that infection.
Giraldo
Paulo C
PC
Department of Gynecology and Obstetrics, State University of Campinas, São Paulo, Brazil. giraldo@unicamp.br
Eleutério
Jose
J
Cavalcante
Diane Isabelle M
DI
Gonçalves
Ana Katherine S
AK
Romão
Juliana A A
JA
Eleutério
Renata M N
RM
D000293:Adolescent; D000328:Adult; D002278:Carcinoma in Situ / Q000175:diagnosis / Q000473:pathology / Q000821:virology; D003430:Cross-Sectional Studies; D004279:DNA, Viral / Q000235:genetics*; D003955:Diagnostic Tests, Routine / Q000379:methods; D005260:Female; D052162:Human papillomavirus 16 / Q000235:genetics*; D052161:Human papillomavirus 18 / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D030361:Papillomavirus Infections / Q000175:diagnosis* / Q000473:pathology / Q000635:transmission; D010409:Penile Diseases / Q000175:diagnosis / Q000473:pathology / Q000821:virology*; D010412:Penile Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000821:virology; D010413:Penis / Q000473:pathology / Q000821:virology*; D015995:Prevalence; D012680:Sensitivity and Specificity; D012747:Sexual Partners; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000821:virology
D004279:DNA, Viral