title: Gynura root induces hepatic veno-occlusive disease: a case report and review of the literature.
abstract: Gynura root has been used extensively in Chinese folk medicine and plays a role in promoting microcirculation and relieving pain. However, its hepatic toxicity should not be neglected. Recently, we admitted a 62-year old female who developed hepatic veno-occlusive disease (HVOD) after ingestion of Gynura root. Only a few articles on HVOD induced by Gynura root have been reported in the literature. It is suspected that pyrrolizidine alkaloids in Gynura root might be responsible for HVOD. In this paper, we report a case of HVOD and review the literature.
authors.affiliation: Department of Hepato-gastroenterology, Sir Run Run Shaw Affiliated Hospital of Medical College of Zhejiang University, Hangzhou 310016, Zhejiang Province, China. ndaicn@yahoo.com
authors.forename: Ning
authors.initials: N
authors.lastname: Dai
authors.forename: Ying-Cong
authors.initials: YC
authors.lastname: Yu
authors.forename: Tian-Hua
authors.initials: TH
authors.lastname: Ren
authors.forename: Jia-Guo
authors.initials: JG
authors.lastname: Wu
authors.forename: Yuan
authors.initials: Y
authors.lastname: Jiang
authors.forename: Lai-Gen
authors.initials: LG
authors.lastname: Shen
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
mesh_terms: D019659:Asteraceae / Q000009:adverse effects*; D004365:Drugs, Chinese Herbal / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006504:Hepatic Veno-Occlusive Disease / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D008875:Middle Aged; D019547:Neck Pain / Q000188:drug therapy; D008517:Phytotherapy / Q000009:adverse effects*; D018517:Plant Roots / Q000009:adverse effects*
chemical_list: D004365:Drugs, Chinese Herbal