Risk of metabolic complications in the new PCOS phenotypes based on the Rotterdam criteria.
OBJECTIVE
To determine the risk of metabolic complications, primarily metabolic syndrome, in all polycystic ovary syndrome (PCOS) phenotypes compared with control subjects.


METHODS
Retrospective chart review.


METHODS
University practice.


METHODS
Women with PCOS (Rotterdam definition; n = 258) and women without PCOS seen during the same time period for an annual exam used as controls (n = 110).


METHODS
None.


METHODS
Metabolic syndrome.


RESULTS
Three PCOS phenotypes had a significantly higher prevalence of metabolic syndrome compared with the control subjects: oligomenorrhea/oligo-ovulation (O) + hyperandrogenism (H) + polycystic ovaries (P), age-adjusted odds ratio [OR] 6.3 (95% confidence interval 2.1-18.9); O+H, OR 7.8 (2.2-27.5); and H+P, OR 8.2 (2.3-29.3). There was no significant difference in the prevalence of metabolic syndrome between women with O+P and control subjects, even in obese women. The prevalence of insulin resistance and glucose intolerance was not significantly different between POCS phenotypes


CONCLUSIONS
The risk of metabolic syndrome may vary among the four phenotypes of PCOS based on the Rotterdam criteria. This new information may be of relevance in counseling women with PCOS although larger studies may be needed to validate our findings.
Shroff
Rupal
R
Department of Obstetrics and Gynecology, University of Iowa, Roy J. and Lucille A. Carver College of Medicine, Iowa City, IA 52242, USA.
Syrop
Craig H
CH
Davis
William
W
Van Voorhis
Bradley J
BJ
Dokras
Anuja
A
D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D024821:Metabolic Syndrome / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics / Q000378:metabolism; D008875:Middle Aged; D010641:Phenotype; D011085:Polycystic Ovary Syndrome / Q000175:diagnosis* / Q000453:epidemiology / Q000235:genetics / Q000378:metabolism*; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors