title: A review of near infrared spectroscopy and chemometrics in pharmaceutical technologies.
abstract: Near-infrared spectroscopy (NIRS) is a fast and non-destructive analytical method. Associated with chemometrics, it becomes a powerful tool for the pharmaceutical industry. Indeed, NIRS is suitable for analysis of solid, liquid and biotechnological pharmaceutical forms. Moreover, NIRS can be implemented during pharmaceutical development, in production for process monitoring or in quality control laboratories. This review focuses on chemometric techniques and pharmaceutical NIRS applications. The following topics are covered: qualitative analyses, quantitative methods and on-line applications. Theoretical and practical aspects are described with pharmaceutical examples of NIRS applications.
authors.affiliation: F. Hoffmann-La Roche Ltd., Basel, Switzerland. yves.roggo@roche.com
authors.forename: Yves
authors.initials: Y
authors.lastname: Roggo
authors.forename: Pascal
authors.initials: P
authors.lastname: Chalus
authors.forename: Lene
authors.initials: L
authors.lastname: Maurer
authors.forename: Carmen
authors.initials: C
authors.lastname: Lema-Martinez
authors.forename: Aurélie
authors.initials: A
authors.lastname: Edmond
authors.forename: Nadine
authors.initials: N
authors.lastname: Jent
mesh_terms: D015195:Drug Design; D006801:Humans; D004364:Pharmaceutical Preparations / Q000032:analysis*; D019265:Spectroscopy, Near-Infrared; D013678:Technology, Pharmaceutical / Q000379:methods* / Q000639:trends
chemical_list: D004364:Pharmaceutical Preparations