title: Spleen autotransplantation. Morphological and functional follow-up after spleen autotransplantation in mice: a research summary.
abstract: In 1986, we started the research on spleen surgery aimed at saving the splenic mass after its traumatic injury, with elaboration of special resection and autotransplantation techniques. The researches started on mongrel dogs and were continued on inbred mice and beagle dogs with complex histological, imaging, and laboratory investigations, following-up the function and the regeneration of autotransplanted spleen chips. Performing research on mice provided more immunological methods, such as lymphocyte subsets, immunoglobulin levels, and monitoring the phagocytic functions. Researches showed evidence also on the presence of apoptosis, furthermore, stem cell studies on regeneration and functional restoration of the spleen chips are in progress. Our results contributed to two multidisciplinary guidelines in Hungary: (1) One of them is under preparation and underlines the importance of spleen saving methods after traumatic splenic injury; (2) The second guideline shows that hemorheological changes can be early indicators of the increased sensitivity to postsplenectomy infections.
authors.affiliation: Department of Operative Techniques and Surgical Research, Institute of Surgery, University of Debrecen, Medical and Health Science Center, H-4032 Debrecen, Nagyerdei krt. 98, Hungary. imiko@dote.hu
authors.forename: Iren
authors.initials: I
authors.lastname: Miko
authors.forename: Endre
authors.initials: E
authors.lastname: Brath
authors.forename: Norbert
authors.initials: N
authors.lastname: Nemeth
authors.forename: Andrea
authors.initials: A
authors.lastname: Furka
authors.forename: Sandor
authors.initials: S
authors.lastname: Sipka
authors.forename: Katalin
authors.initials: K
authors.lastname: Peto
authors.forename: Jozsef
authors.initials: J
authors.lastname: Serfozo
authors.forename: Judit
authors.initials: J
authors.lastname: Kovacs
authors.forename: Sandor
authors.initials: S
authors.lastname: Imre
authors.forename: Ilona
authors.initials: I
authors.lastname: Benko
authors.forename: Laszlo
authors.initials: L
authors.lastname: Galuska
authors.forename: Sandor
authors.initials: S
authors.lastname: Sipka
authors.forename: Geza
authors.initials: G
authors.lastname: Acs
authors.forename: Istvan
authors.initials: I
authors.lastname: Furka
mesh_terms: D000328:Adult; D000818:Animals; D004285:Dogs; D006801:Humans; D008137:Longitudinal Studies; D051379:Mice; D008815:Mice, Inbred Strains; D023421:Models, Animal; D017410:Practice Guidelines as Topic; D012038:Regeneration; D013154:Spleen / Q000473:pathology / Q000502:physiology / Q000637:transplantation*; D013156:Splenectomy; D014182:Transplantation, Autologous / Q000379:methods / Q000502:physiology