title: Platelet phospholipid n-3 PUFA negatively associated with plasma homocysteine in middle-aged and geriatric hyperlipaemia patients.
abstract: Studies showed that increased dietary intake of n-3 polyunsaturated fatty acids (PUFA) has a cardiovascular beneficial effect. Increased plasma phospholipid (PL) docosahexaenoic acid (22:6n-3) is associated with decreased plasma homocysteine (Hcy). The aim of this study was to investigate the relationship between platelet PL fatty acid and plasma Hcy in middle-aged and geriatric hyperlipaemia patients (50 males, 31 females) and 65 healthy subjects (43 males, 22 females) in Hangzhou, China. Plasma Hcy demonstrated significant positive correlation with adrenic acid (22:4n-6) (r = 0.188, P = 0.018) and negative correlation with 22:6n-3 (r = -0.277, P = 0.001) and the ratio of n-3/n-6 (r = -0.231, P = 0.003) in sex-, age- and BMI-controlled partial correlation analysis. The present results suggest that increased ratio of n-3/n-6 PUFA in platelet PL is associated with decreased thrombotic risks such as plasma Hcy in middle-aged and geriatric hyperlipaemia patients in Hangzhou.
authors.affiliation: Department of Food Science and Nutrition, Zhejiang University, 268 Kaixuan Road, Hangzhou, Zhejiang 310029, China. duoli@zju.edu.cn
authors.forename: D
authors.initials: D
authors.lastname: Li
authors.forename: X M
authors.initials: XM
authors.lastname: Yu
authors.forename: H B
authors.initials: HB
authors.lastname: Xie
authors.forename: Y H
authors.initials: YH
authors.lastname: Zhang
authors.forename: Q
authors.initials: Q
authors.lastname: Wang
authors.forename: X Q
authors.initials: XQ
authors.lastname: Zhou
authors.forename: P
authors.initials: P
authors.lastname: Yu
authors.forename: L J
authors.initials: LJ
authors.lastname: Wang
mesh_terms: D000368:Aged; D001792:Blood Platelets / Q000737:chemistry*; D015525:Fatty Acids, Omega-3 / Q000378:metabolism*; D005260:Female; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010743:Phospholipids / Q000737:chemistry / Q000378:metabolism*; D013223:Statistics as Topic
chemical_list: D015525:Fatty Acids, Omega-3; D010743:Phospholipids; D006710:Homocysteine