title: Primary diffuse large B-cell lymphoma of the testis: a case-report.
abstract: We report a case of a primary non-Hodgkin lymphoma of the testis in a 74-year-old man presented with a 1-month history of testicular swelling. The patient was submitted to right inguinal orchidectomy for the definitive diagnosis. Light microscopy demonstrated sheets of lymphoma cells involving epididymis and rete testis, but mainly extended into testicular parenchyma. The malignant cells were large with scant cytoplasm and large vesicular nuclei, the classic appearance of a diffuse large B-cell lymphoma. The immunohistochemical study was carried out, with the tumour cells being intensively positive for CD45, CD20 and Ki67 nuclear proliferative antigen. Clinical and pathological features of this non-Hodgkin lymphoma are described and discussed.
authors.affiliation: Istituto di Anatomia Patologica, Seconda Università degli Studi, Napoli, Italy.
authors.forename: Maria Gaetana
authors.initials: MG
authors.lastname: Lamendola
authors.forename: Franca
authors.initials: F
authors.lastname: Ferraraccio
authors.forename: Umberto
authors.initials: U
authors.lastname: Pane
authors.forename: Giovanni
authors.initials: G
authors.lastname: De Luca
authors.forename: Massimino
authors.initials: M
authors.lastname: D'Armiento
authors.forename: Riccardo
authors.initials: R
authors.lastname: Autorino
mesh_terms: D000368:Aged; D018951:Antigens, CD20 / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000032:analysis; D017493:Leukocyte Common Antigens / Q000032:analysis; D016403:Lymphoma, Large B-Cell, Diffuse / Q000737:chemistry / Q000276:immunology / Q000473:pathology / Q000601:surgery; D008297:Male; D009919:Orchiectomy; D013736:Testicular Neoplasms / Q000737:chemistry / Q000276:immunology / Q000473:pathology / Q000601:surgery; D016896:Treatment Outcome
chemical_list: D018951:Antigens, CD20; D014408:Biomarkers, Tumor; D019394:Ki-67 Antigen; D017493:Leukocyte Common Antigens; C516769:PTPRC protein, human