Quantitative liquid chromatography/time-of-flight mass spectrometry.
Over the last decade, time-of-flight (TOF) instruments have increasingly been used as quantitation tools. In addition, because of their high resolving power, they can be used for verification of empirical formulas. Historically, TOF instruments have had limited quantitation capabilities because of their narrow dynamic range. However, recent advances have improved these limitations. This review covers the rationale for using TOF for LC detection, and describes the many methods currently in the literature for the quantitation of pharmaceuticals, environmental pollutants, explosives and many phytochemicals.
Williamson
Leah N
LN
Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, The University of Georgia, Athens, GA 30602-2352, USA.
Bartlett
Michael G
MG
D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D004350:Drug Residues / Q000032:analysis; D004785:Environmental Pollutants / Q000032:analysis; D053834:Explosive Agents / Q000032:analysis; D005504:Food Analysis; D010573:Pesticide Residues / Q000032:analysis; D010936:Plant Extracts / Q000032:analysis; D020543:Proteome / Q000032:analysis; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D021241:Spectrometry, Mass, Electrospray Ionization / Q000295:instrumentation* / Q000379:methods* / Q000592:standards
D004785:Environmental Pollutants; D053834:Explosive Agents; D010573:Pesticide Residues; D010936:Plant Extracts; D020543:Proteome