title: Probing the low-frequency vibrational modes of viruses with Raman scattering--bacteriophage M13 in water.
abstract: Raman spectroscopy is used to study low-wave-number (</=20 cm(-1)) acoustic vibrations of the M13 phage. A well-defined Raman line is observed at around 8.5 cm(-1). The experimental results are compared with theoretical calculations based on an elastic continuum model and appropriate Raman selection rules derived from a bond polarizability model. The observed Raman mode is shown to belong to one of the Raman-active axial modes of the M13 phage protein coat. It is expected that the detection and characterization of this low-frequency vibrational mode can be used for applications in biomedical nanotechnology such as for monitoring the process of virus functionalization and self-assembly.
authors.affiliation: Arizona State University, Department of Physics, Tempe, Arizona 85287-1504, USA. tsen@asu.edu
authors.forename: Kong T
authors.initials: KT
authors.lastname: Tsen
authors.forename: Eric C
authors.initials: EC
authors.lastname: Dykeman
authors.forename: Otto F
authors.initials: OF
authors.lastname: Sankey
authors.forename: Shaw-Wei D
authors.initials: SW
authors.lastname: Tsen
authors.forename: Nien-Tsung
authors.initials: NT
authors.lastname: Lin
authors.forename: Juliann G
authors.initials: JG
authors.lastname: Kiang
mesh_terms: D017104:Bacteriophage M13 / Q000145:classification / Q000302:isolation & purification* / Q000502:physiology*; D012542:Scattering, Radiation; D013059:Spectrum Analysis, Raman / Q000379:methods*; D014732:Vibration; D019065:Virus Assembly / Q000502:physiology*; D014867:Water
chemical_list: D014867:Water