[Evaluation of individual vulnerability to HIV infection of health care employees--hope or reality?].
Due to the increasing number of infections with hepatitis viruses and HIV, world wide as well as among the health care workers, the prevention of occupationally acquired infections in the operating room environment becomes crucial. Three plausible strategies do not require any knowledge of the exact mechanisms of exposure: vaccination, impenetrable protective barriers and post exposure prophylaxis. This paper presents the opinion on individual risks of HIV infections based on genetic factors. It has been proved that one of the CCR5 gene varient for chemokine receptor is related with resistance to HIV-1 infection. Similary, the level of cytokine depends on the number of gene CCL3L1 copy and it influences susceptibility to HIV-1 infection and AIDS development.
Białecki
Piotr
P
Katedra i Klinika Ortopedii i Traumatologii, Pomorskiej Akademii Medycznej w Szczecinie. pbialecki@byss.pl
Kurzawski
Mateusz
M
Gańczak
Maria
M
Białecka
Monika
M
D000163:Acquired Immunodeficiency Syndrome / Q000235:genetics / Q000517:prevention & control / Q000635:transmission; D017848:Blood-Borne Pathogens; D019742:Chemokines, CC / Q000235:genetics / Q000276:immunology; D020022:Genetic Predisposition to Disease; D015658:HIV Infections / Q000235:genetics / Q000517:prevention & control* / Q000635:transmission*; D006282:Health Personnel; D006509:Hepatitis B / Q000517:prevention & control / Q000635:transmission; D006801:Humans; D017758:Infectious Disease Transmission, Patient-to-Professional / Q000517:prevention & control*; D017757:Infectious Disease Transmission, Professional-to-Patient / Q000517:prevention & control; D009784:Occupational Diseases / Q000235:genetics / Q000517:prevention & control*; D019713:Receptors, CCR5 / Q000235:genetics / Q000276:immunology; D012108:Research Personnel; D012307:Risk Factors
C492767:CCL3L1 protein, human; D019742:Chemokines, CC; D019713:Receptors, CCR5