Synthetic pores with sticky pi-clamps.
In this report, we describe design, synthesis, evaluation and molecular dynamics simulations of synthetic multifunctional pores with pi-acidic naphthalenediimide clamps. Experimental evidence is provided for the formation of unstable but inert, heterogeneous and acid-insensitive dynamic tetrameric pores that are sensitive to base and ionic strength. Blockage experiments reveal that the introduction of aromatic electron donor-acceptor interactions provides access to the selective recognition of pi-basic intercalators within the pore. This breakthrough is important for the application of synthetic pores as multianalyte sensors.
Tanaka
Hiroyuki
H
Department of Organic Chemistry, University of Geneva, Geneva, Switzerland.
Bollot
Guillaume
G
Mareda
Jiri
J
Litvinchuk
Svetlana
S
Tran
Duy-Hien
DH
Sakai
Naomi
N
Matile
Stefan
S