title: Clinical and immunohistochemical differentiation of gastrointestinal stromal tumors from leiomyosarcomas in dogs: 42 cases (1990-2003).
abstract: OBJECTIVE
  To reexamine (via immunohistochemical techniques) canine tissue samples that had been previously classified as gastrointestinal leiomyosarcomas (GILMSs), identify and differentiate gastrointestinal stromal tumors (GISTs) from GILMSs, and compare the biological behavior and clinical course of GISTs and GILMSs in dogs.
  
  
  METHODS
  Retrospective case series.
  
  
  METHODS
  42 dogs.
  
  
  METHODS
  Medical records of 42 dogs for which a histologic diagnosis of GILMS was confirmed were reviewed for signalment, clinical signs, physical examination findings, results of initial diagnostic tests, surgical findings, adjunctive treatment, location of the tumor, completeness of resection, and outcome after surgery. Archived tumor tissue specimens from each dog were restained via immunohistochemical techniques to differentiate tumor types. Long-term follow-up information was obtained from the medical record or through telephone interviews with owners and referring veterinarians.
  
  
  RESULTS
  On the basis of immunohistochemical findings, 28 of 42 tumors were reclassified as GISTs and 4 were reclassified as undifferentiated sarcomas; 10 tumors were GILMSs. In dogs, GISTs developed more frequently in the cecum and large intestine and GILMSs developed more frequently in the stomach and small intestine. Median survival times for dogs with GISTs and GILMSs were 11.6 and 7.8 months, respectively; if only dogs surviving the perioperative period were considered, median survival times were 37.4 and 7.8 months, respectively. These differences, however, were not significant.
  
  
  CONCLUSIONS
  In dogs, many previously diagnosed GILMSs should be reclassified as GISTs on the basis of results of immunohistochemical staining. The biological behavior of these tumors appears to be different.
authors.affiliation: Matthew J. Ryan Veterinary Hospital, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
authors.forename: Kelli N
authors.initials: KN
authors.lastname: Russell
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Mehler
authors.forename: Katherine A
authors.initials: KA
authors.lastname: Skorupski
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Baez
authors.forename: Frances S
authors.initials: FS
authors.lastname: Shofer
authors.forename: Michael H
authors.initials: MH
authors.lastname: Goldschmidt
mesh_terms: D000818:Animals; D003937:Diagnosis, Differential; D004283:Dog Diseases / Q000175:diagnosis / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D004285:Dogs; D005260:Female; D046152:Gastrointestinal Stromal Tumors / Q000175:diagnosis / Q000401:mortality / Q000473:pathology / Q000662:veterinary*; D007150:Immunohistochemistry / Q000379:methods / Q000662:veterinary*; D007890:Leiomyosarcoma / Q000175:diagnosis / Q000401:mortality / Q000473:pathology / Q000662:veterinary*; D008297:Male; D012189:Retrospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome