MGMT: a personal perspective.
This review describes the history of studies on alkylation damage of mammalian genomes and its carcinogenic consequences that led to the discovery of a unique DNA repair protein, named MGMT. MGMT repairs O(6)-alkylguanine, a critical mutagenic lesion induced by alkylating agents. The follow-up studies in mammalian cells following the discovery of the ubiquitous repair protein in E. coli are summarized.
Mitra
Sankar
S
Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, USA. samitra@utmb.edu
D000477:Alkylating Agents / Q000633:toxicity; D000818:Animals; D003001:Cloning, Molecular; D015254:DNA Modification Methylases / Q000235:genetics / Q000266:history; D004260:DNA Repair; D045643:DNA Repair Enzymes / Q000235:genetics / Q000266:history; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics / Q000378:metabolism; D006147:Guanine / Q000031:analogs & derivatives / Q000737:chemistry; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D008769:Methylnitronitrosoguanidine / Q000633:toxicity; D009154:Mutation; D019853:O(6)-Methylguanine-DNA Methyltransferase / Q000235:genetics / Q000266:history; D025521:Tumor Suppressor Proteins / Q000235:genetics / Q000266:history
D000477:Alkylating Agents; D025521:Tumor Suppressor Proteins; D008769:Methylnitronitrosoguanidine; D006147:Guanine; C008449:O-(6)-methylguanine; D015254:DNA Modification Methylases; C515491:MGMT protein, human; D019853:O(6)-Methylguanine-DNA Methyltransferase; D045643:DNA Repair Enzymes