Searching genomes for ribozymes and riboswitches.
New regulatory RNAs with complex structures have recently been discovered, among them the first catalytic riboswitch, a gene-regulatory RNA sequence with catalytic activity. Here we discuss some of the experimental approaches and theoretical difficulties attached to the identification of new ribozymes in genomes.
Hammann
Christian
C
Research Group Molecular Interactions, Department of Genetics, FB 18 Naturwissenschaften, Universität Kassel, Kassel, Germany.
Westhof
Eric
E
D001483:Base Sequence; D019295:Computational Biology; D017124:Conserved Sequence; D014644:Genetic Variation; D016678:Genome; D023281:Genomics / Q000379:methods; D009690:Nucleic Acid Conformation; D012326:RNA Splicing; D016337:RNA, Catalytic / Q000737:chemistry / Q000502:physiology*; D038621:Regulatory Sequences, Ribonucleic Acid / Q000502:physiology*
D016337:RNA, Catalytic; D038621:Regulatory Sequences, Ribonucleic Acid