title: Embryonal rhabdomyosarcoma in an immature Baird's tapir (Tapirus bairdii).
abstract: An immature Baird's tapir (Tapirus bairdii) with a history of seizure-like episodes developed signs of respiratory disease. The initial clinical diagnosis was pneumonia, and antibiotic therapy was started. The animal failed to improve after 14 days of therapy and developed unilateral, bloody nasal discharge. Endoscopic examination and radiography revealed a soft tissue mass in the nasopharynx depressing the soft palate. The tapir died 32 days after initial presentation. Histologic examination of the mass demonstrated a mesenchymal tumor composed of spindle cells with elongate nuclei forming densely packed fascicles. The neoplastic spindle cells showed prominent cross-striations. Immunohistochemistry revealed the cells to be positive for desmin and myoglobin, but negative for smooth muscle actin, confirming diagnosis of rhabdomyosarcoma. Embryonal rhabdomyosarcoma is the most common nasopharyngeal soft tissue tumor of humans, and it has been reported infrequently in dogs, horses, and pigs. Neoplasia should be a differential diagnosis in cases of unilateral nasal discharge and inspiratory stridor, even in young animals.
authors.affiliation: Cleveland Metroparks Zoo, Ohio 44109, USA.
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Bonar
authors.forename: Albert H
authors.initials: AH
authors.lastname: Lewandowski
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Skowronek
mesh_terms: D000818:Animals; D000836:Animals, Zoo; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D007150:Immunohistochemistry / Q000662:veterinary; D008297:Male; D009303:Nasopharyngeal Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D010527:Perissodactyla; D018233:Rhabdomyosarcoma, Embryonal / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*