title: Brain metastasis and carcinomatous meningitis from vulvar squamous cell carcinoma: case report.
abstract: BACKGROUND
  Brain metastasis and carcinomatous meningitis from gynecological tumors are an uncommon event, usually related to choriocarcinoma, ovarian and cervical cancer.
  
  
  METHODS
  A 74-year-old woman was diagnosed with locally advanced vulvar squamous carcinoma. Initial therapy consisted of multiagent chemotherapy and vulvar, pelvis and groin irradiation. The patient subsequently developed widely spread metastatic disease including brain and meningeal metastases.
  
  
  CONCLUSIONS
  The rising incidence of central nervous system metastasis in the last two decades is probably associated with treatment-related improvement in life expectancy. To our knowledge, this is the first case reported of brain metastases and meningeal carcinomatosis associated with vulvar squamous cell carcinoma.
authors.affiliation: Oncology Department, Hospital Clinic San Carlos, Madrid, Spain.
authors.forename: J Puente
authors.initials: JP
authors.lastname: Vázquez
authors.forename: S López-Tarruella
authors.initials: SL
authors.lastname: Cobo
authors.forename: F M
authors.initials: FM
authors.lastname: Antón
authors.forename: A C
authors.initials: AC
authors.lastname: Asado
authors.forename: J A
authors.initials: JA
authors.lastname: Vidart
authors.forename: P
authors.initials: P
authors.lastname: Coronado
authors.forename: E
authors.initials: E
authors.lastname: Díaz-Rubio
mesh_terms: D000368:Aged; D001932:Brain Neoplasms / Q000556:secondary* / Q000628:therapy; D002294:Carcinoma, Squamous Cell / Q000556:secondary* / Q000628:therapy; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008577:Meningeal Neoplasms / Q000556:secondary* / Q000628:therapy; D014846:Vulvar Neoplasms / Q000473:pathology* / Q000628:therapy