title: Effects of polydipsia-hyponatremia on seizures in patients with epilepsy.
abstract: Aggravation of seizures due to hyponatremia was investigated in five patients with epilepsy and polydipsia-hyponatremia. They experienced marked increases in the frequency of their complex partial seizures with a decrease in the serum sodium level to 118-127 mEq/L. In all cases, the serum sodium level returned to normal through restriction of fluids, and the clinical seizures improved. All patients had shown intellectual impairment and/or psychotic episodes, and all had been given antipsychotics. Hyponatremia caused by polydipsia appears to be a risk factor for aggravation of habitual seizures in patients with epilepsy.
authors.affiliation: Department of Psychiatry, National Center of Neurology and Psychiatry, Musashi Hospital, Kodaira, Tokyo, Japan. okazakim@ncnp.go.jp
authors.forename: Mitsutoshi
authors.initials: M
authors.lastname: Okazaki
authors.forename: Masumi
authors.initials: M
authors.lastname: Ito
authors.forename: Masaaki
authors.initials: M
authors.lastname: Kato
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use; D004327:Drinking Behavior; D004569:Electroencephalography; D004827:Epilepsy / Q000150:complications* / Q000503:physiopathology; D017029:Epilepsy, Complex Partial / Q000150:complications / Q000503:physiopathology; D005260:Female; D006801:Humans; D007010:Hyponatremia / Q000150:complications* / Q000503:physiopathology; D008279:Magnetic Resonance Imaging; D008297:Male; D012640:Seizures / Q000150:complications* / Q000503:physiopathology; D012964:Sodium / Q000097:blood; D014057:Tomography, X-Ray Computed
chemical_list: D014150:Antipsychotic Agents; D012964:Sodium