title: Micronucleus test in buccal epithelium cells from patients subjected to panoramic radiography.
abstract: OBJECTIVE
  To evaluate the possible genotoxic effect of radiation exposure for dental diagnostic purposes as measured by the formation of micronuclei.
  
  
  METHODS
  The micronucleus test was applied to buccal epithelium cells, which are target cells for dental radiography. Specimens of exfoliated buccal cells were collected from patients subjected to panoramic radiography. Samples were obtained from 32 patients, 12 male and 20 female, aged from 24 years to 73 years, before and 10+/-2 days after panoramic radiation exposure.
  
  
  RESULTS
  No significant increase in the frequency of cells with micronuclei and total number of micronuclei after panoramic tomography was detected. Mean values of buccal cells with micronuclei+/-standard deviation (SD) before and after radiation examination were 2.34+/-1.49% and 2.81+/-1.64%, respectively. A significant correlation between the age of investigated subjects and the initial frequency of micronuclei in buccal cells was observed (r=0.60, P<0.01).
  
  
  CONCLUSIONS
  Panoramic radiographic examination does not induce micronuclei in target buccal epithelium cells.
authors.affiliation: Laboratory Radiation Genetics, National Centre of Radiobiology and Radiation Protection, Sofia 1756, Bulgaria.
authors.forename: L
authors.initials: L
authors.lastname: Popova
authors.forename: D
authors.initials: D
authors.lastname: Kishkilova
authors.forename: V B
authors.initials: VB
authors.lastname: Hadjidekova
authors.forename: R P
authors.initials: RP
authors.lastname: Hristova
authors.forename: P
authors.initials: P
authors.lastname: Atanasova
authors.forename: V V
authors.initials: VV
authors.lastname: Hadjidekova
authors.forename: D
authors.initials: D
authors.lastname: Ziya
authors.forename: V G
authors.initials: VG
authors.lastname: Hadjidekov
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D002610:Cheek; D004247:DNA / Q000528:radiation effects; D004249:DNA Damage; D004847:Epithelial Cells / Q000528:radiation effects*; D005260:Female; D006801:Humans; D008297:Male; D015162:Micronucleus Tests; D008875:Middle Aged; D009061:Mouth Mucosa / Q000528:radiation effects*; D011862:Radiography, Panoramic / Q000009:adverse effects*; D018709:Statistics, Nonparametric
chemical_list: D004247:DNA