title: A novel artemisinin-quinine hybrid with potent antimalarial activity.
abstract: Artemisinin was reduced to dihydroartemisinin and coupled to a carboxylic acid derivative of quinine via an ester linkage. This novel hybrid molecule had potent activity against the 3D7 and (drug-resistant) FcB1 strains of Plasmodium falciparum in culture. The activity was superior to that of artemisinin alone, quinine alone, or a 1:1 mixture of artemisinin and quinine.
authors.affiliation: School of Pharmacy and Pharmaceutical Sciences, Panoz Institute, Trinity College Dublin, Dublin 2, Ireland. jjwalsh@tcd.ie <jjwalsh@tcd.ie>
authors.forename: John J
authors.initials: JJ
authors.lastname: Walsh
authors.forename: David
authors.initials: D
authors.lastname: Coughlan
authors.forename: Nicola
authors.initials: N
authors.lastname: Heneghan
authors.forename: Caroline
authors.initials: C
authors.lastname: Gaynor
authors.forename: Angus
authors.initials: A
authors.lastname: Bell
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000494:pharmacology*; D037621:Artemisinins / Q000737:chemistry / Q000494:pharmacology*; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D015195:Drug Design; D020128:Inhibitory Concentration 50; D008956:Models, Chemical; D021261:Parasitic Sensitivity Tests; D010963:Plasmodium falciparum; D011803:Quinine / Q000737:chemistry / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D000962:Antimalarials; D037621:Artemisinins; C031327:artemisinin; D011803:Quinine