title: Characterisation of methicillin-resistant Staphylococcus aureus isolates from dogs and their owners.
abstract: Ten methicillin-resistant Staphylococcus aureus (MRSA) isolates from healthy owners and their pets were characterised by susceptibility testing, staphylococcal chromosome cassette (SCC)mec and agr typing, and detection of the Panton-Valentine leukocidin (PVL) genes. Two human and three dog isolates harbouring SCCmec type III appeared to be of hospital origin. The five remaining isolates carried SCCmec type IV, with three being multidrug-resistant. One type IV isolate was PVL-positive and a prototypic agr type 3, typified by strain MW2. This is the first report of this type in association with nasal carriage. Drug resistance may be increasing among community isolates of MRSA.
authors.affiliation: Department of Health Technology & Informatics, The Hong Kong Polytechnic University, Hong Kong. htmboost@polyu.edu.hk
authors.forename: M V
authors.initials: MV
authors.lastname: Boost
authors.forename: M M
authors.initials: MM
authors.lastname: O'Donoghue
authors.forename: K H G
authors.initials: KH
authors.lastname: Siu
mesh_terms: D000818:Animals; D000829:Animals, Domestic / Q000382:microbiology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001426:Bacterial Proteins / Q000235:genetics; D001427:Bacterial Toxins; D015373:Bacterial Typing Techniques; D002876:Chromosomes, Bacterial / Q000235:genetics; D004197:Disease Reservoirs; D004285:Dogs / Q000382:microbiology*; D005098:Exotoxins; D006801:Humans; D007956:Leukocidins; D016106:Methicillin Resistance / Q000235:genetics; D008826:Microbial Sensitivity Tests; D009296:Nasal Cavity / Q000382:microbiology; D013203:Staphylococcal Infections / Q000382:microbiology / Q000635:transmission; D013211:Staphylococcus aureus / Q000145:classification* / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification*; D015534:Trans-Activators / Q000235:genetics
chemical_list: C095698:Agr protein, Staphylococcus aureus; D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D001427:Bacterial Toxins; D005098:Exotoxins; D007956:Leukocidins; C078284:Panton-Valentine leukocidin; D015534:Trans-Activators