Treatment of feline hypertension with transdermal amlodipine: a pilot study.
This prospective study evaluated transdermal amlodipine for the control of hypertension in six cats. Cats were treated with oral amlodipine until blood pressures decreased to <180 mm Hg. They were maintained on this dose for 7 days and then administered identical doses of transdermal amlodipine for 7 days. Oral amlodipine decreased pressure by a median of 73 mm Hg, which subsequently increased by 20 mm Hg after 7 days of transdermal amlodipine. Plasma concentrations of amlodipine were measured after oral and transdermal dosing. Additional studies are needed to determine dosing, pharmacokinetics, and efficacy.
Helms
Scott Roderick
SR
Unifour Veterinary Referrals, Hickory, North Carolina 28602, USA.
D000279:Administration, Cutaneous; D000284:Administration, Oral; D017311:Amlodipine / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics; D000818:Animals; D000959:Antihypertensive Agents / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics; D001682:Biological Availability; D001794:Blood Pressure / Q000187:drug effects; D002371:Cat Diseases / Q000188:drug therapy*; D002415:Cats; D005260:Female; D006973:Hypertension / Q000188:drug therapy / Q000662:veterinary*; D008297:Male; D008954:Models, Biological; D010865:Pilot Projects; D011446:Prospective Studies
D000959:Antihypertensive Agents; D017311:Amlodipine