title: Impact of aspirin intolerance on outcomes of sinus surgery.
abstract: OBJECTIVE
  To compare objective and quality of life (QOL) outcomes after endoscopic sinus surgery (ESS) in aspirin (ASA)-tolerant patients and ASA-intolerant patients over intermediate and long-term follow-up.
  
  
  METHODS
  Prospective analysis of a cohort of patients with chronic rhinosinusitis.
  
  
  METHODS
  Preoperative computed tomography (CT), pre- and postoperative endoscopy, and two validated disease specific QOL instruments, the Rhinosinusitis Disability Index (RSDI) and Chronic Sinusitis Survey (CSS), were collected. Differences in the proportions of patients who improved were analyzed using Pearson's chi-square and Fisher's exact test.
  
  
  RESULTS
  Nineteen ASA-intolerant patients and 104 ASA-tolerant patients were followed for a mean of 17.7 months. Patients with ASA intolerance had significantly worse preoperative CT (P < .0001) and endoscopy scores (P < .0001). After ESS, 57% to 74% of patients improved on endoscopy scores, 63% to 71% improved on the RSDI, and 58% to 73% improved on the CSS; improvement did not significantly differ by ASA status.
  
  
  CONCLUSIONS
  Similar proportions of ASA-tolerant and ASA-intolerant patients showed improvement on endoscopy and QOL measures after ESS.
authors.affiliation: Oregon Health and Science University, Portland, Oregon 97201, USA. robinjam@ohsu.edu
authors.forename: Jamie L
authors.initials: JL
authors.lastname: Robinson
authors.forename: Susan
authors.initials: S
authors.lastname: Griest
authors.forename: Kenneth E
authors.initials: KE
authors.lastname: James
authors.forename: Timothy L
authors.initials: TL
authors.lastname: Smith
mesh_terms: D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D001241:Aspirin / Q000009:adverse effects*; D016009:Chi-Square Distribution; D002908:Chronic Disease; D004342:Drug Hypersensitivity / Q000150:complications*; D004724:Endoscopy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011788:Quality of Life; D012220:Rhinitis / Q000000981:diagnostic imaging / Q000601:surgery*; D012852:Sinusitis / Q000000981:diagnostic imaging / Q000601:surgery*; D018709:Statistics, Nonparametric; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001241:Aspirin