title: Lack of association between LTA and LGALS2 polymorphisms and myocardial infarction in Japanese and Korean populations.
abstract: To investigate the recently reported associations of polymorphisms in lymphotoxin-alpha (LTA) and galectin-2 (LGALS2) with myocardial infarction (MI), we analyzed a single nucleotide polymorphism of LTA (LTA 252A>G in LTA intron 1) and that of LGALS2 (LGALS2 3279C>T in LGALS2 intron 1) in Japanese and Korean populations. Although significant associations with MI were not observed in either population, we found that LTA 252GG was significantly associated with the severity of the disease for both the Japanese and Korean populations (P=0.017 and P=0.001, respectively). On the other hand, the polymorphism of LGALS2 was not associated with the severity of coronary atherosclerosis. These observations showed that, while the LTA 252GG genotype might modify the development of coronary atherosclerosis, the relation of LTA and LGALS2 to MI itself remained much less certain.
authors.affiliation: Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan. akitis@mri.tmd.ac.jp
authors.forename: A
authors.initials: A
authors.lastname: Kimura
authors.forename: M
authors.initials: M
authors.lastname: Takahashi
authors.forename: B Y
authors.initials: BY
authors.lastname: Choi
authors.forename: S W
authors.initials: SW
authors.lastname: Bae
authors.forename: S
authors.initials: S
authors.lastname: Hohta
authors.forename: T
authors.initials: T
authors.lastname: Sasaoka
authors.forename: K-i
authors.initials: KI
authors.lastname: Nakahara
authors.forename: K
authors.initials: K
authors.lastname: Chida
authors.forename: M
authors.initials: M
authors.lastname: Sawabe
authors.forename: M
authors.initials: M
authors.lastname: Yasunami
authors.forename: T
authors.initials: T
authors.lastname: Naruse
authors.forename: T
authors.initials: T
authors.lastname: Izumi
authors.forename: J-E
authors.initials: JE
authors.lastname: Park
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D003324:Coronary Artery Disease / Q000235:genetics; D005260:Female; D037501:Galectin 2 / Q000235:genetics*; D006801:Humans; D007564:Japan; D007723:Korea; D008233:Lymphotoxin-alpha / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
chemical_list: D037501:Galectin 2; C511926:LGALS2 protein, human; D008233:Lymphotoxin-alpha