Region-specific DNA methylation in the preimplantation embryo as a target for genomic plasticity.
It has been long known that the unique genetic sequence each embryo inherits is not the sole determinant of phenotype. However, only recently have epigenetic modifications to DNA been implicated in providing potential developmental plasticity to the embryonic and fetal genome, with environmental influences directly altering the epigenetic modifications that contribute to tissue-specific gene regulation. Most is known about the potential environmental regulation of DNA methylation, epigenetic addition of methyl groups to cytosine residues in DNA that acts in the long-term silencing of affected sequences. While most attention has been paid to the methylation of imprinted gene sequences, in terms of developmental plasticity there are many more parts of the genome that are methylated and that could be affected. This review explores the distribution of cytosine methylation in the genome and discusses the potential effects of regional plasticity on subsequent development. Widening our consideration of potentially plastic regions is likely to greatly enhance our understanding of how individuals are shaped not only by DNA sequence, but by the environment in which pluripotent embryonic cells are transformed into the many cell types of the body.
Thurston
A
A
Wolfson Centre for Stem cells, Tissue Engineering and Modelling (STEM), University of Nottingham, Centre for Biomolecular Sciences, University Park, Nottingham NG7 2RD, UK.
Lucas
E S
ES
Allegrucci
C
C
Steele
W
W
Young
L E
LE
D000818:Animals; D001665:Binding Sites; D001755:Blastocyst / Q000378:metabolism*; D018899:CpG Islands / Q000502:physiology; D019175:DNA Methylation; D015254:DNA Modification Methylases / Q000378:metabolism / Q000502:physiology; D018507:Gene Expression Regulation, Developmental; D016678:Genome / Q000502:physiology*; D018392:Genomic Imprinting; D006801:Humans; D008954:Models, Biological; D020080:Tandem Repeat Sequences / Q000502:physiology
D015254:DNA Modification Methylases