Arterial plasma vasopressin and aldosterone predict left ventricular mass in men who develop hypertension over 20 years.
Left ventricular (LV) hypertrophy is related to blood pressure level and neurohormonal factors. The authors previously demonstrated that arterial norepinephrine levels predict LV mass in middle-aged men who developed hypertension through 20 years. The aim of this 20-year prospective study was to investigate arterial vasopressin, aldosterone, and renin as long-term predictors of LV mass. Normotensives (n=17), subjects who developed hypertension (n=17), and sustained hypertensives (n=22) were compared at baseline (42 years) and at follow-up (62 years). There were no significant differences in baseline vasopressin, aldosterone, or renin levels. The group with sustained hypertension had more LV hypertrophy (P=.025) at follow-up. Among new hypertensives, multiple regression analysis demonstrated that baseline arterial vasopressin (beta-0.53; P=.041) and aldosterone (beta-0.56;P=.032) independently explained LV mass index (R(2)=0.85; P=.035). In conclusion, baseline arterial vasopressin and aldosterone, but not renin, appear to predict LV mass in middle-aged men who developed hypertension over a 20-year period.
Strand
Arne H
AH
Department of Cardiology, Ullevaal University Hospital, Oslo, Norway. a.h.strand@medisin.uio.no
Gudmundsdottir
Helga
H
Fossum
Eigil
E
Os
Ingrid
I
Bjørnerheim
Reidar
R
Kjeldsen
Sverre E
SE
D000328:Adult; D000450:Aldosterone / Q000097:blood*; D000704:Analysis of Variance; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001158:Arteries; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure / Q000187:drug effects; D003430:Cross-Sectional Studies; D004452:Echocardiography; D005500:Follow-Up Studies; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology; D017379:Hypertrophy, Left Ventricular / Q000097:blood* / Q000150:complications* / Q000000981:diagnostic imaging / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012044:Regression Analysis; D012083:Renin / Q000097:blood / Q000187:drug effects; D013997:Time Factors; D014667:Vasopressins / Q000097:blood* / Q000187:drug effects
D000959:Antihypertensive Agents; D015415:Biomarkers; D014667:Vasopressins; D000450:Aldosterone; D012083:Renin