title: The role of Granzyme B in atheromatous diseases.
abstract: The mechanism and role of apoptotic cell death in the pathogenesis of atheromatous diseases is an area of intense research. Atherosclerosis is an inflammatory disease and as such, immune-mediated cell killing plays an important role. Recent studies have suggested that Granzyme B and perforin play an important role in atherogenesis. The current manuscript reviews our current understanding pertaining to the role of Granzyme B in cardiac allograft vasculopathy and atherosclerosis.
authors.affiliation: James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St. Paul's Hospital, University of British Columbia, 1081 Burrard St, Vancouver, BC V6Z 1Y6, Canada.
authors.forename: Ciara M
authors.initials: CM
authors.lastname: Chamberlain
authors.forename: David J
authors.initials: DJ
authors.lastname: Granville
mesh_terms: D000818:Animals; D017209:Apoptosis; D050197:Atherosclerosis / Q000201:enzymology* / Q000473:pathology; D003324:Coronary Artery Disease / Q000201:enzymology* / Q000209:etiology / Q000473:pathology; D005109:Extracellular Matrix / Q000378:metabolism; D053804:Granzymes / Q000378:metabolism*; D016027:Heart Transplantation / Q000009:adverse effects*; D006801:Humans; D008562:Membrane Glycoproteins / Q000378:metabolism*; D054353:Perforin; D052899:Pore Forming Cytotoxic Proteins / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D008562:Membrane Glycoproteins; D052899:Pore Forming Cytotoxic Proteins; D054353:Perforin; D053804:Granzymes