title: HPLC-SPE-NMR characterization of sesquiterpenes in an antimycobacterial fraction from Warburgia salutaris.
abstract: HPLC-SPE-NMR analysis of a chemically complex antimycobacterial fraction of Warburgia salutaris allowed the rapid identification of seven new and four known drimane- and coloratane-type sesquiterpenes. This recently introduced hyphenated technique is therefore a highly valuable tool for elucidation of the chemistry of biologically active fractions of natural origin.
authors.affiliation: Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Cailean
authors.initials: C
authors.lastname: Clarkson
authors.forename: Eliya V
authors.initials: EV
authors.lastname: Madikane
authors.forename: Steen Honoré
authors.initials: SH
authors.lastname: Hansen
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Smith
authors.forename: Jerzy W
authors.initials: JW
authors.lastname: Jaroszewski
mesh_terms: D000995:Antitubercular Agents / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D019684:Magnoliopsida; D009161:Mycobacterium; D008517:Phytotherapy; D024301:Plant Bark; D010936:Plant Extracts / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry; D052616:Solid Phase Extraction; D013329:Structure-Activity Relationship
chemical_list: D000995:Antitubercular Agents; D010936:Plant Extracts; D012717:Sesquiterpenes