title: Symptomatic calcification of subureteral collagen ten years after injection.
abstract: Bovine glutaraldehyde cross-linked collagen is an injectable bulking agent used to treat urinary incontinence and vesicoureteral reflux. A 16-year-old girl had previously undergone left subureteral injection of collagen at the age of 6 years. She presented to our clinic after passing a 7-mm calcification with a history of hematuria and intermittent back pain. Computed tomography showed two hyperdense foci measuring 2 mm each in the region of the left ureterovesical junction that did not change on follow-up imaging. On cystoscopy, two submucosal calcifications were located medially and inferiorly to the left ureteral orifice and were removed endoscopically.
authors.affiliation: Division of Pediatric Urology, University of Iowa, Iowa City, Iowa 52242-1089, USA.
authors.forename: Kenneth G
authors.initials: KG
authors.lastname: Nepple
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Knudson
authors.forename: Christopher S
authors.initials: CS
authors.lastname: Cooper
authors.forename: J Christopher
authors.initials: JC
authors.lastname: Austin
mesh_terms: D000293:Adolescent; D002114:Calcinosis / Q000139:chemically induced* / Q000601:surgery; D003094:Collagen / Q000008:administration & dosage / Q000009:adverse effects*; D003558:Cystoscopy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015552:Injections, Intralesional; D018570:Risk Assessment; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014515:Ureteral Diseases / Q000139:chemically induced* / Q000601:surgery; D018666:Ureteroscopy; D014718:Vesico-Ureteral Reflux / Q000175:diagnosis / Q000628:therapy*
chemical_list: C048470:glutaraldehyde-cross-linked collagen; D003094:Collagen