Reversible hepatotoxicity, pancreatitis, coagulation disorder and simultaneous bone marrow suppression with valproate in a 2-year-old girl.
Valproic acid (VPA) is considered to be a drug of first choice for the therapy of generalized and focal epilepsies, including special epileptic syndromes like the WEST-syndrome. The drug is usually well tolerated; rare serious complications may occur in some patients, including haemorrhagic pancreatitis, coagulapathies, bone marrow suppression, VPA-induced hepatotoxicity and encephalopathy. We report a case of combined appearance of several severe VPA-associated side effects in a two- and a half-year-old girl with lissencephaly.
Gerstner
Thorsten
T
University Children's Hospital, Theodor-Kutzer-Ufer 1-3, 69167 Mannheim, Germany. thorsten-gerstner@web.de
Bauer
Marc-Oliver
MO
Longin
Elke
E
Bell
Nellie
N
Koenig
Stephan A
SA
D001778:Blood Coagulation Disorders / Q000139:chemically induced*; D001855:Bone Marrow Diseases / Q000139:chemically induced*; D056486:Chemical and Drug Induced Liver Injury; D002675:Child, Preschool; D004828:Epilepsies, Partial / Q000188:drug therapy; D005260:Female; D006801:Humans; D010195:Pancreatitis / Q000139:chemically induced*; D014635:Valproic Acid / Q000009:adverse effects*
D014635:Valproic Acid