Genome integrity: a HAT needs a chaperone.
Histone acetylation helps to maintain integrity of the yeast replisome in response to genotoxic agents. Four groups have now identified protein Rtt109p as the catalytic subunit of a novel histone H3 acetylase complex that harbors a histone chaperone subunit essential for significant activity.
Peterson
Craig L
CL
Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA. craig.peterson@umassmed.edu
D004260:DNA Repair; D042822:Genomic Instability / Q000235:genetics*; D051548:Histone Acetyltransferases / Q000378:metabolism*; D006657:Histones / Q000235:genetics / Q000378:metabolism*; D008958:Models, Molecular; D018832:Molecular Chaperones / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000235:genetics*; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism*
D006657:Histones; D018832:Molecular Chaperones; D029701:Saccharomyces cerevisiae Proteins; D051548:Histone Acetyltransferases; C517120:Rtt109 protein, S cerevisiae