Clostridium difficile-associated diarrhea after living donor liver transplantation.
OBJECTIVE
To assess the incidence and analyze the risk factors for Clostridium difficile-associated diarrhea (CDAD) after living donor liver transplantation (LDLT) in adult.


METHODS
The microbiological data and medical records of 242 adult recipients that underwent LDLT at the Tokyo University Hospital were analyzed retrospectively. The independent risk factors for postoperative CDAD were identified.


RESULTS
Postoperative CDAD occurred in 11 (5%) patients. Median onset of CDAD was postoperative d 19 (range, 5-54). In the multivariate analyses, male gender (odds ratio, 4.56) and serum creatinine (>or= 1.5 mg/dL, odds ratio, 16.0) independently predicted postoperative CDAD.


CONCLUSIONS
CDAD should be considered in the differential diagnosis of patients with postoperative diarrhea after LDLT.
Hashimoto
Masao
M
Artificial Organ and Transplantation Division, Department of Surgery, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.
Sugawara
Yasuhiko
Y
Tamura
Sumihito
S
Kaneko
Junichi
J
Matsui
Yuichi
Y
Togashi
Junichi
J
Makuuch
Masatoshi
M
D000293:Adolescent; D000328:Adult; D000368:Aged; D016360:Clostridioides difficile; D003404:Creatinine / Q000097:blood; D003967:Diarrhea / Q000382:microbiology*; D004761:Enterocolitis, Pseudomembranous / Q000150:complications* / Q000209:etiology; D005260:Female; D006801:Humans; D015994:Incidence; D016031:Liver Transplantation / Q000009:adverse effects*; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D051437:Renal Insufficiency / Q000097:blood / Q000150:complications; D012189:Retrospective Studies; D012307:Risk Factors; D012737:Sex Factors
D003404:Creatinine