title: Role of the toll-like receptor 4 polymorphism Asp299Gly in longevity and myocardial infarction in German men.
abstract: In a previous study on Sicilian men, an association of the functional polymorphism Asp299Gly in the TLR4 gene was reported with longevity and a reduced risk of myocardial infarction (MI). Here, we sought to confirm the findings in our extensive collection of 273 long-lived men (95-107 years), 606 male early-onset MI patients and 594 appropriate controls from Germany. Despite sufficient statistical power to replicate the findings observed in the South Italians, our results rule out a noteworthy influence of the TLR4 polymorphism upon human longevity or MI in German men. Therefore, the previously described associations in Sicilians might reflect either population-specific or potentially false-positive results.
authors.affiliation: Institute of Clinical Molecular Biology, Christian-Albrechts-University Kiel, Germany.
authors.forename: Almut
authors.initials: A
authors.lastname: Nebel
authors.forename: Friederike
authors.initials: F
authors.lastname: Flachsbart
authors.forename: Arne
authors.initials: A
authors.lastname: Schäfer
authors.forename: Michael
authors.initials: M
authors.lastname: Nothnagel
authors.forename: Susanna
authors.initials: S
authors.lastname: Nikolaus
authors.forename: Nour Eddine El
authors.initials: NE
authors.lastname: Mokhtari
authors.forename: Stefan
authors.initials: S
authors.lastname: Schreiber
mesh_terms: D000328:Adult; D000368:Aged; D019943:Amino Acid Substitution; D001224:Aspartic Acid / Q000737:chemistry / Q000235:genetics; D005858:Germany; D005998:Glycine / Q000737:chemistry / Q000235:genetics; D006801:Humans; D008136:Longevity / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000235:genetics*; D011110:Polymorphism, Genetic; D051197:Toll-Like Receptor 4 / Q000235:genetics*
chemical_list: C495345:TLR4 protein, human; D051197:Toll-Like Receptor 4; D001224:Aspartic Acid; D005998:Glycine