DNA structure and human diseases.
Recently, multiple lines of evidences have shown that non-B DNA structures within the human genes may lead to chromosomal translocations, deletions and amplifications in cancer and other human diseases. In this review, we summarize the current literature on non-B DNA structures, and discuss their role in genomic instability and diseases.
Raghavan
Sathees C
SC
Department of Biochemistry, Indian Institute of Science, Bangalore, India. sathees@biochem.iisc.ernet.in
Lieber
Michael R
MR
D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D004194:Disease; D006801:Humans; D009690:Nucleic Acid Conformation
D004247:DNA