Mammalian specific mouse genes are evolving faster than mouse genes conserved across other eukaryotic lineages.
Positive selection is usually considered in the context of a higher rate of substitutions in non-synonymous as compared to synonymous sites in complete coding sequences of genes or individual positions. We show that genes conserved in eukaryota, coelomata, and bilateria, that is, proteins that arose earlier in evolution as compared to mammalia specific genes evolve slowly and are subjected to negative selection. This finding supports the notion that evolutionary rates progressively diminish with the age of a gene. The data suggests that in both intron-containing and intronless genes synonymous sites may be subject to some degree of selection that is indicative of a relative acceleration of amino-acid substitution, which could be due to a relaxation of functional constraints and/or directional selection.
Chaturvedi
Iti
I
Advanced design and modeling lab, Affiliated staff BioInformatics Research Centre, Nanyang Technological University, Singapore.
Hlaing
Mya Myintzu
MM
Sing
Lim Chu
LC
Sakharkar
Kishore R
KR
Sakharkar
Meena Kishore
MK
D000818:Animals; D005075:Biological Evolution; D003062:Codon; D018076:DNA, Complementary; D006801:Humans; D007438:Introns; D051379:Mice
D003062:Codon; D018076:DNA, Complementary