Evidence that the spread of Mycobacterium tuberculosis strains with the Beijing genotype is human population dependent.
This study describes a comparative analysis of the Beijing mycobacterial interspersed repetitive unit types of Mycobacterium tuberculosis isolates from Cape Town, South Africa, and East Asia. The results show a significant association between the frequency of occurrence of strains from defined Beijing sublineages and the human population from whom they were cultured (P < 0.0001).
Hanekom
M
M
DST/NRF Centre of Excellence for Biomedical Tuberculosis Research/MRC Centre for Molecular and Cellular Biology, Division of Molecular Biology and Human Genetics, Faculty of Health Sciences, Stellenbosch University, South Africa.
van der Spuy
G D
GD
Gey van Pittius
N C
NC
McEvoy
C R E
CR
Ndabambi
S L
SL
Victor
T C
TC
Hoal
E G
EG
van Helden
P D
PD
Warren
R M
RM
D002681:China; D005202:Asia, Eastern / Q000453:epidemiology; D005838:Genotype; D006801:Humans; D009169:Mycobacterium tuberculosis / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification*; D011110:Polymorphism, Genetic; D011157:Population Dynamics; D013019:South Africa / Q000453:epidemiology; D014397:Tuberculosis, Pulmonary / Q000453:epidemiology / Q000382:microbiology* / Q000635:transmission*