[Clinical observation of autoinflammatory diseases].
A disease, which repeats inflammations but is not based on infections or autoimmunity, was recently defined as autoinflammatory diseases. The autoinflammatory diseases are a new and expanding classification of inflammatory diseases characterized by recurrent episodes of systemic inflammation in the absence of pathogens, autoantibodies or antigen specific T cells. This disease is developed by the abnormality of molecules which regulate inflammation, innate immunity and apoptosis, and patients have been suffered with treatment by the difficulty of making a diagnosis. However, a diagnosis is comparatively easy by their presenting the characteristic clinical observation. In addition, genetic analysis can put the diagnosis on a firm basis. Giving that therapies for individual disorder of autoinflammatory diseases are different, we always put these disorders in mind when we saw patients who have unknown persistent inflammation.
Agematsu
Kazunaga
K
Department of Infectious Immunology and Pediatrics, Graduate School of Medicine, Shinshu University.
D005334:Fever / Q000209:etiology; D006801:Humans; D007249:Inflammation / Q000175:diagnosis / Q000235:genetics; D013577:Syndrome