title: Results of chemotherapy for pulmonary metastases of carcinoma of the cervix in patients after primary surgical and radiotherapeutic management.
abstract: The purpose of this study was to evaluate the results of chemotherapy of pulmonary metastases from invasive carcinoma of the cervix, which were detected after a disease-free period after initial treatment with surgery or radiotherapy. Fifty patients with radiologically proven pulmonary metastases were treated with chemotherapy. All patients received a platinum-5-fluorouracil (PF) program: cisplatin 75 mg/m(2) and 5-fluorouracil 800 mg/m(2) every 4 weeks. The overall 1- and 3-year survival after PF chemotherapy was 62% and 17.6%, respectively. The progression-free survival at 1 and 3 years was 36.7% and 14.3%, respectively. There were 6 (12%) complete responses and 17 (34%) partial responses. Hematologic tolerance was acceptable. Third degree and fourth degree leukopenia was diagnosed in four (8%) and six (12%) patients, respectively. Three individuals had third degree thrombocytopenia. In the multivariate analysis, the following prognostic factors were associated with poor survival: time to recurrence after primary treatment (P= 0.002), number of lung metastases (P= 0.016), and progression during chemotherapy (P= 0.001). We conclude that PF regimen is a safe and reasonably effective chemotherapy in the management of patients with pulmonary metastases after primary treatment for invasive carcinoma of the cervix who do not qualify for surgical metastasectomy.
authors.affiliation: Department of Gynecologic Oncology, The Maria Sklodowska-Curie Memorial Cancer Center, Warsaw, Poland. gmpanek@wp.pl
authors.forename: G
authors.initials: G
authors.lastname: Panek
authors.forename: K
authors.initials: K
authors.lastname: Gawrychowski
authors.forename: P
authors.initials: P
authors.lastname: Sobiczewski
authors.forename: P
authors.initials: P
authors.lastname: Derlatka
authors.forename: A
authors.initials: A
authors.lastname: Danska-Bidzinska
authors.forename: L
authors.initials: L
authors.lastname: Gmyrek
authors.forename: M
authors.initials: M
authors.lastname: Bidzinski
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002277:Carcinoma / Q000000981:diagnostic imaging / Q000556:secondary* / Q000601:surgery; D005260:Female; D005472:Fluorouracil / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000556:secondary; D008875:Middle Aged; D010984:Platinum / Q000009:adverse effects / Q000627:therapeutic use*; D011859:Radiography; D013921:Thrombocytopenia / Q000139:chemically induced; D016896:Treatment Outcome; D002583:Uterine Cervical Neoplasms / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery
chemical_list: D010984:Platinum; D005472:Fluorouracil