Association between fasting plasma glucose and left ventricular mass and left ventricular hypertrophy over 4 years in a healthy population aged 60 and older.
OBJECTIVE
To test the association between fasting glucose level and left ventricular mass (LVM) and left ventricular hypertrophy (LVH) in people aged 60 and older.


METHODS
Population-based prospective study with 4-year follow-up.


METHODS
Department of Internal Medicine and Family Medicine, Kaohsiung Medical University (KMU), Chung-Ho Memorial Hospital, and Graduate Institute of Medicine and Public Health, KMU.


METHODS
Of 1,500 people screened, 105 without symptoms or signs of diabetes mellitus, hypertension, or cardiovascular disease were recruited from senior activity centers in Kaohsiung city.


METHODS
All received two-dimensional echocardiography and fasting glucose examination at baseline and at 2- and 4-year follow-up. LVH was defined as a LVM index (LVMI) greater than 122.4 g/m(2) or 51 g/m(2.7).


RESULTS
Age ranged from 60 to 81 (mean 71.7+/-3.9). Baseline glucose ranged from 83 to 118 mg/dL (mean 99.7+/-7.9 mg/dL). LVMI was significantly higher at the 4-year follow-up (97.5+/-24.9 vs 104.5+/-27.5 g/m(2) and 44.2+/-12.1 vs 47.2+/-13.4 g/m(2.7), both P<.01), as was the occurrence of LVH (16% vs 32% and 25% vs 39%, both P<.01). Baseline glucose correlates with 4-year change in LVMI (both P<.02). In the fourth year, baseline glucose was a significant predictor of LVMI (both P<.01) and LVH (P=.03 in g/m(2) definition) using logistic regression analysis.


CONCLUSIONS
Because fasting glucose is an independent predictor for greater LVM and for development of LVH, it should be considered in assessment of cardiac disease and LVM in healthy older people without diabetes mellitus.
Lin
Tsung-Hsien
TH
Division of Cardiology, Department of Internal Medicine, Koahsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
Chiu
Herng-Chia
HC
Su
Ho-Ming
HM
Voon
Wen-Chol
WC
Liu
Hong-Wen
HW
Lai
Wen-Ter
WT
Sheu
Sheng-Hsiung
SH
D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000097:blood / Q000473:pathology* / Q000502:physiology; D001786:Blood Glucose / Q000032:analysis*; D001794:Blood Pressure; D004452:Echocardiography; D004562:Electrocardiography; D005215:Fasting; D005260:Female; D006352:Heart Ventricles / Q000473:pathology*; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000097:blood* / Q000000981:diagnostic imaging; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged
D001786:Blood Glucose