Review of vascularized bone marrow transplantation: current status and future clinical applications.
In this review, we examine the applicability of the vascularized bone marrow transplant (VBMT) as an alternative to conventional bone marrow transplantation (BMT). As a new surgical approach, the VBMT is unique by transplantation of the stromal environment that eliminates the need for an engraftment period, provides critical signaling and modulatory functions, and may potentiate tolerance induction. Thus far, VBMT studies have demonstrated an absence of graft-versus-host disease (GVHD) and robust engraftment into nonmanipulated as well as irradiated recipients with evidence of immunological tolerance. Further investigation is needed to determine the applicability of VBMT as an alternative to BMT.
Gordon
Chad R
CR
Division of Surgical Research, Department of Surgery, Robert Wood Johnson Medical School, Cooper University Hospital, Camden, NJ 08103, USA. gordon-chad@cooperhealth.edu
Tai
Chau Y
CY
Suzuki
Hidetoshi
H
Strande
Louise F
LF
Ramsamooj
Rajendra
R
Matthews
Martha S
MS
Black
Kirby S
KS
Hewitt
Charles W
CW
D000818:Animals; D001853:Bone Marrow / Q000098:blood supply*; D016026:Bone Marrow Transplantation / Q000276:immunology*; D046528:Chimerism; D006086:Graft vs Host Disease / Q000276:immunology* / Q000517:prevention & control; D007108:Immune Tolerance; D007165:Immunosuppression Therapy / Q000379:methods; D051379:Mice; D023421:Models, Animal; D033581:Stem Cell Transplantation; D014185:Transplantation, Isogeneic / Q000276:immunology / Q000379:methods