[Immunological and pathogenetic aspects of imunofan administration in aged patients with duodenal ulcer].
OBJECTIVE
To specify immunological and pathogenetic aspects of imunophan use in aged patients with duodenal ulcer (DU).


METHODS
Imunophan was given to 24 DU patients (mean age 62.0 +/- 1.5 years), in whom the size of ulcer varied from 0.6 to 2.1 cm.


RESULTS
The patients on anti-ulcer therapy plus imunophan had a pain relief median 6.2 +/- 0.2 days (p < 0.001), control ones--11.8 +/- 0.1 days. The median of scarring duration in the test group was 16.2 +/- 0.2 days (p < 0.001), in the controls--23.8 +/- 0.3 days. In 3 (30.0%) cases the scars were rough. The count of T-lymphocytes in the study group increased from 53.1 +/- 0.6 to 65.1 +/- 0.2% (p < 0.001), of T-helpers/inductors--from 27.8 +/- 0.2 to 38.5 +/- 0.3% (p < 0.001), of cytotoxic T-lymphocytes--from 18.5 +/- 0.5 to 27.3 +/- 0.3 (p < 0.001), of B-lymphocytes--from 12.3 +/- 0.2 to 19.1 +/- 0.1% (p < 0.001). The therapy including imunophan reduced concentration of malonic dialdehide by 23.5%, trienic conjugates by 61.6%; raised the level of superoxide dismutase 1.6-fold, catalase 1.4-fold, glutathione reductase by 41.9% (p < 0.001). Neither immune status nor LPO-AOD changed significantly in patients on the basic therapy alone.


CONCLUSIONS
The results obtained evidence for a positive action of imunophan on inflammation, immune status and antioxidant defense. Therefore, imunophan can be recommended as an adjuvant of basic anti-ulcer therapy in elderly and senile patients.
Butorov
I V
IV
Osoianu
Iu P
IuP
Butorov
S I
SI
Maksimov
V V
VV
D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D018450:Disease Progression; D004381:Duodenal Ulcer / Q000188:drug therapy / Q000276:immunology / Q000503:physiopathology; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000187:drug effects / Q000276:immunology*; D007962:Leukocytes / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000037:antagonists & inhibitors; D008875:Middle Aged; D009842:Oligopeptides / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D013482:Superoxide Dismutase / Q000037:antagonists & inhibitors
D000276:Adjuvants, Immunologic; D007070:Immunoglobulin A; D009842:Oligopeptides; C080035:thymohexin; D008315:Malondialdehyde; D013482:Superoxide Dismutase