The effects of soygerm extracts on blood lipoproteins, antioxidative capacity and urinary estrogen metabolites in postmenopausal women on hormone therapy.
OBJECTIVE
To evaluate the effects of soygerm isoflavones extracts on blood lipoproteins, antioxidative capacity and urinary estrogen metabolites in postmenopausal women who receive hormone therapy (HT).


METHODS
Thirty-nine volunteers receiving HT were recruited, and 33 completed the study. All subjects received 6 g of soygerm extracts per day for 4 weeks. Blood and urine samples were collected for study at the beginning and at the end of study.


RESULTS
Plasma HDL-C levels increased markedly with significant decreases of plasma LDL-C/HDL-C ratio and LDL-TG levels. The lag time of conjugated dienes formation prolonged for 9.9% and thiobarbituric acid reactive substances production in copper-catalyzed oxidation of LDL decreased. The differences were statistically significant. Urinary ratio of 2-OHE(1) to 16alpha-OHE(1) increased without statistical significance.


CONCLUSIONS
Soygerm extracts may improve serum lipid profile in postmenopausal Taiwanese women who receive HT, and probably provide a favorable effect on estrogen metabolism.
Hsu
I P
IP
Department of Child and Family Studies, Fu-Jen Catholic University, Taiwan.
Jou
H J
HJ
Huang
C W
CW
Wang
T A
TA
Wu
W H
WH
D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D008076:Cholesterol, HDL / Q000097:blood / Q000187:drug effects; D008078:Cholesterol, LDL / Q000097:blood / Q000187:drug effects; D003300:Copper; D015914:Estrogen Replacement Therapy; D004967:Estrogens / Q000378:metabolism / Q000652:urine*; D005260:Female; D006801:Humans; D006894:Hydroxyestrones / Q000652:urine; D007529:Isoflavones / Q000737:chemistry / Q000494:pharmacology*; D008077:Lipoproteins, LDL / Q000097:blood / Q000187:drug effects; D008875:Middle Aged; D010084:Oxidation-Reduction; D010865:Pilot Projects; D010936:Plant Extracts / Q000494:pharmacology*; D017698:Postmenopause; D013025:Glycine max / Q000737:chemistry*; D013624:Taiwan; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D014280:Triglycerides / Q000097:blood
D000975:Antioxidants; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D004967:Estrogens; D006894:Hydroxyestrones; D007529:Isoflavones; D008077:Lipoproteins, LDL; D010936:Plant Extracts; D017392:Thiobarbituric Acid Reactive Substances; D014280:Triglycerides; C032607:low density lipoprotein triglyceride; C026702:16-hydroxyestrone; D003300:Copper; C024980:2-hydroxyestrone