Association of CCR2 polymorphisms with the number of closed coronary artery vessels in coronary artery disease.
Coronary artery disease (CAD) is one of the most common forms of heart disease. It has been demonstrated that chemokine-mediated inflammation is associated with the development of CAD. In this study, in order to determine the role of CCR2, a receptor for MCP-1, in the development of CAD, we initially sequenced and identified the genetic variants of CCR2 using 24 unrelated Korean individuals' DNA samples. A total of 13 genetic variants, including 1 deletion and 12 SNPs, were identified in the Korean population. Although we could not detect any association of CCR2 polymorphic markers with CAD, several SNP markers of CCR2 gene showed highly significant signals with the number of arteries with significant coronary artery stenosis in the CAD male patients. The most significant signal was detected at the SNP located at exon 2 (+780T>C, Asn260Asn) CI: 1.19-1.87, P=0.0005 (odds ratio: 1.49, 95% CI: 1.19-1.87, p=0.0005) (Table 3). This result indicates that CCR2 can play a role in the pathogenesis of CAD, especially to the number of vessels in CAD.
Cha
Seung-Hun
SH
National Genome Research Institute, National Institute of Health, 5 Nokbun-Dong, Eunpyung-Ku, Seoul, South Korea.
Lee
Jong-Keuk
JK
Lee
Jong-Young
JY
Kim
Hung Tae
HT
Ryu
Ha-Jung
HJ
Han
Bok Ghee
BG
Kim
Jun Woo
JW
Oh
Bermseok
B
Kimm
Kuchan
K
Shin
Hyung-Doo
HD
Park
Byung Lae
BL
Park
Sungha
S
Park
Hyun-Young
HY
Jang
Yangsoo
Y
D003324:Coronary Artery Disease / Q000208:ethnology / Q000235:genetics* / Q000473:pathology*; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D007723:Korea; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D054390:Receptors, CCR2; D019707:Receptors, Chemokine / Q000235:genetics*
C515334:CCR2 protein, human; D054390:Receptors, CCR2; D019707:Receptors, Chemokine