title: Quantification of iodide and sodium-iodide symporter inhibitors in human urine using ion chromatography tandem mass spectrometry.
abstract: We developed a sensitive and selective method for quantifying nitrate, thiocyanate, perchlorate and iodide in human urine using ion chromatography coupled with electrospray ionization tandem mass spectrometry. Analysis of proficiency testing materials and spiked urine indicates that the method is precise (coefficients of variation <5%) and accurate (relative percent differences <7.9%). Analytical response was linear across the physiologically relevant concentration range for the analytes, and adequately sensitive to quantify the analytes in >99% of urine samples tested. Measurement of these four toxicologically-related analytes in one assay will provide useful information for assessing potential linkage between exposure and health effects.
authors.affiliation: Division of Laboratory Sciences, National Center for Environmental Health, CDC, Atlanta, GA 30341, USA. LValentin@cdc.gov
authors.forename: Liza
authors.initials: L
authors.lastname: Valentín-Blasini
authors.forename: Benjamin C
authors.initials: BC
authors.lastname: Blount
authors.forename: Amy
authors.initials: A
authors.lastname: Delinsky
mesh_terms: D002852:Chromatography, Ion Exchange / Q000379:methods*; D006801:Humans; D007454:Iodides / Q000652:urine*; D009573:Nitrites / Q000652:urine; D010472:Perchlorates / Q000652:urine; D015203:Reproducibility of Results; D027981:Symporters / Q000037:antagonists & inhibitors*; D053719:Tandem Mass Spectrometry / Q000379:methods*; D013861:Thiocyanates / Q000652:urine; D000099209:Sodium-Iodide Symporters
chemical_list: D007454:Iodides; D009573:Nitrites; D010472:Perchlorates; D027981:Symporters; D013861:Thiocyanates; D000099209:Sodium-Iodide Symporters; C031760:thiocyanate; C494474:perchlorate