title: Intensive observation of toxic side effects after several-year of cyclosporin treatment in kidney transplant patient.
abstract: In this work we are going to show results of intensive observation of adverse reactions of cyclosporine therapy during 18 months. The research was applied on 30 patients with kidney transplant. The medium time of kidney transplant survival was 9,7+/-2,3 years, with time span of 6 to 15 years. All the patients were subjects to several years' cyclosporine treatment, which was applied on a daily basis with a dosage of 2 to 5 mg/kg of body weight. The concentration of cyclosporine in blood was measured once a month. The concentration of cyclosporine in blood in 19 patients was in referent values of 122,50 nag/ml up to 280,50 nag/ml of blood. In 4 of the patients the concentration was heightened up to 370 to 538 nag/ml (X=766,37 nag/ml), and in 7 patients cyclosporine was below normal dosage down to 30,78 to 96,30 nag/ml in blood (x=77,12 nag/ml). We noticed these toxic side effects: increased values of systolic and diastolic arterial blood pressure in 5 patients, neurotoxic tremor effects in 4 patients, hyperplasia gingival and hirsute in 1 patient each.
authors.affiliation: Department of Pharmacology and Toxicology, Faculty of Medicine, University of Tuzla, Univerzitetska 1, 75000 Tuzla, Bosnia and Herzegovina.
authors.forename: Mensura
authors.initials: M
authors.lastname: Asćerić
authors.forename: Sevleta
authors.initials: S
authors.lastname: Avdić
authors.forename: Sabrija
authors.initials: S
authors.lastname: Nukić
authors.forename: Muamera
authors.initials: M
authors.lastname: Vrabac-Mujcinagić
mesh_terms: D000328:Adult; D016572:Cyclosporine / Q000009:adverse effects* / Q000097:blood / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D005260:Female; D006084:Graft Rejection / Q000517:prevention & control; D006470:Hemorrhage / Q000139:chemically induced; D006628:Hirsutism / Q000139:chemically induced; D006801:Humans; D006949:Hyperlipidemias / Q000139:chemically induced; D006973:Hypertension / Q000139:chemically induced; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000097:blood / Q000627:therapeutic use; D007674:Kidney Diseases / Q000139:chemically induced; D016030:Kidney Transplantation; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D014202:Tremor / Q000139:chemically induced
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine