Cytoskeletal elements and intracellular transport.
Recent advances in the understanding of the functions of various components of the cytoskeleton indicate that, besides serving a structural role, the cytoskeletal elements may regulate the transport of several proteins in the cell. Studies reveal that there are co-operative interactions between the actin and microtubule cytoskeletons including functional overlap in the transport influenced by different motor families. Multiple motors are probably involved in the control of the dynamics of many proteins and intriguing hints about how these motors are co-ordinated are appearing. It has been shown that some of the intermediate elements also participate in selected intracellular transport mechanisms. In view of the author's preoccupation with the steroid receptor systems, special attention has been given to the role of the cytoskeletal elements, particularly actin, in the intracellular transport of steroid receptors and receptor-related proteins.
Bhaskar
Lakshmi
L
Department of Industrial Microbiology, Govt. College for Women, Vazhuthacaud, Trivandrum 695014, Kerala, India.
Krishnan
Vidya S
VS
Thampan
Raghava Varman
RV
D000818:Animals; D001419:Bacteria / Q000378:metabolism; D001692:Biological Transport; D003599:Cytoskeleton / Q000378:metabolism*; D004705:Endocytosis; D005089:Exocytosis; D006801:Humans; D051379:Mice; D009474:Neurons / Q000378:metabolism; D010587:Phagocytosis; D014780:Viruses / Q000378:metabolism