Cadmium cation increases the production and mRNA levels of insulin-like growth factor-binding protein-1 in HepG2.
The production of insulin-like growth factor-binding protein-1 (IGFBP-1) in HepG2 was increased by cadmium cation (Cd2+) at 3 microM, but not by other divalent cations. The mRNA level of IGFBP-1 was also increased by the administration of 3 microM of Cd(2+). These results suggest that Cd(2+) impacts the gene expression of IGFBP-1, which leads to production of IGFBP-1.
Oishi
Yuichi
Y
Department of Nutritional Sciences, Faculty of Applied Bioscience, Tokyo University of Agriculture, Tokyo, Japan. y3oishi@nodai.ac.jp
Ohnishi
Motoko
M
Kobayashi-Hattori
Kazuo
K
Takita
Toshichika
T
Noguchi
Tadashi
T
D002104:Cadmium / Q000494:pharmacology*; D006528:Carcinoma, Hepatocellular / Q000378:metabolism* / Q000473:pathology; D002412:Cations / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005562:Formazans / Q000378:metabolism; D006801:Humans; D018970:Insulin-Like Growth Factor Binding Protein 1 / Q000096:biosynthesis*; D008113:Liver Neoplasms / Q000378:metabolism* / Q000473:pathology; D012333:RNA, Messenger / Q000378:metabolism*; D013778:Tetrazolium Salts / Q000378:metabolism; D013997:Time Factors
D002412:Cations; D005562:Formazans; D018970:Insulin-Like Growth Factor Binding Protein 1; D012333:RNA, Messenger; D013778:Tetrazolium Salts; D002104:Cadmium; C079782:MTT formazan