C-type natriuretic peptide in individuals with normal left ventricular systolic function.
OBJECTIVE
The objective of this study was to evaluate production or release of CNP in individuals without CHF.


METHODS
Nineteen patients with symptomatic paroxysmal supraventricular tachycardia (PSVT) and normal left ventricular systolic function were enrolled into the study. Blood samples were collected from the coronary sinus (CS), the femoral artery (FA), and the peripheral vein (PV) before pacing, after rapid RA pacing, and post electrophysiological study (EPS) and/or radiofrequency (RF) ablation.


RESULTS
The CNP level in the CS, compared to FA and PV, was significantly higher before pacing (CS, 3.2+/-0.8; FA, 2.6+/-0.7; PV, 2.5+/-0.5 pg/ml; CS vs. either FA or PV, both p<0.001), after the pacing (CS, 3.2+/-1.3; FA, 2.4+/-0.6 pg/ml; p=0.004), and post the EPS and/or RF ablation (CS, 3.1+/-0.7; FA, 2.6+/-0.9; PV, 2.5+/-0.8 pg/ml; CS vs. either FA or PV, both p<0.01).


CONCLUSIONS
The myocardium regularly produces or releases CNP in patients with normal LV systolic function. Brief periods of rapid RA pacing, PSVT, or EPS does not change the production and/or release.
Kuo
Jen-Yuan
JY
Division of Cardiology, Department of Internal Medicine, Mackay Memorial Hospital, Mackay Medicine, Nursing, and Management College, and National Yang-Ming University, School of Medicine, Taipei, Taiwan.
Yeh
Hung-I
HI
Chang
Sheng-Hsiung
SH
Shih
Bing-Fu
BF
Wang
An-Mei
AM
Chen
Chun-Yen
CY
Hou
Charles Jia-Yin
CJ
D000328:Adult; D015415:Biomarkers / Q000097:blood; D017115:Catheter Ablation; D022062:Electrophysiologic Techniques, Cardiac; D005260:Female; D005263:Femoral Artery; D006801:Humans; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism*; D020098:Natriuretic Peptide, C-Type / Q000097:blood*; D013599:Systole; D013614:Tachycardia, Paroxysmal / Q000097:blood* / Q000503:physiopathology / Q000601:surgery; D013617:Tachycardia, Supraventricular / Q000097:blood* / Q000503:physiopathology / Q000601:surgery; D014680:Veins; D016277:Ventricular Function, Left
D015415:Biomarkers; D020098:Natriuretic Peptide, C-Type