Synthesis of two diastereomeric C1-C22 fragments of spirastrellolide A.
The optimisation of a synthetic strategy towards the ABC segment of the cytotoxic macrolide spirastrellolide A is reported, together with its application to the synthesis of two diastereomeric C(1)-C(22) fragments for stereochemical correlation purposes with a putative spirastrellolide degradation product.
Paterson
Ian
I
University Chemical Laboratory, Lensfield Road, Cambridge, UK. ip100@cam.ac.uk
Anderson
Edward A
EA
Dalby
Stephen M
SM
Genovino
Julien
J
Lim
Jong Ho
JH
Moessner
Christian
C
D000447:Aldehydes / Q000737:chemistry; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000138:chemical synthesis* / Q000737:chemistry; D001895:Boron / Q000737:chemistry; D018360:Crystallography, X-Ray; D007202:Indicators and Reagents; D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D010084:Oxidation-Reduction; D011161:Porifera / Q000737:chemistry; D013141:Spiro Compounds; D013237:Stereoisomerism
D000447:Aldehydes; D000903:Antibiotics, Antineoplastic; D007202:Indicators and Reagents; D018942:Macrolides; D013141:Spiro Compounds; C475125:spirastrellolide A; D001895:Boron