Solid dispersion adsorbates for enhancement of dissolution rates of drugs.
Amalgamation of solid dispersion and melt adsorption technologies was utilized for enhancing the dissolution rate of poorly soluble drugs. Glibenclamide was employed as a model drug. PEG6000 and Gelucire44/14 were used as hydrophilic carriers for the preparation of solid dispersions, and lactose was utilized as an adsorbent for the preparation of solid dispersion adsorbates. A high dissolution rate of solid dispersion adsorbates was observed when compared to solid dispersions alone and one of the marketed products.
Deepti
Faculty of Pharmaceutical Sciences, M.D. University, Rohtak, India.
Dureja
Harish
H
Madan
A K
AK
D000327:Adsorption; D002626:Chemistry, Pharmaceutical; D004337:Drug Carriers; D005905:Glyburide / Q000737:chemistry; D007004:Hypoglycemic Agents / Q000737:chemistry; D007700:Kinetics; D007785:Lactose / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*; D012995:Solubility; D013499:Surface Properties; D013678:Technology, Pharmaceutical / Q000379:methods; D013696:Temperature
D004337:Drug Carriers; D007004:Hypoglycemic Agents; C104509:gelucire 44-14; D011092:Polyethylene Glycols; D007785:Lactose; D005905:Glyburide