title: Echolucent carotid plaques predict in-stent restenosis after bare metal stenting in native coronary arteries.
abstract: Echolucent carotid plaque is considered to predict coronary events. This study examined whether echolucent carotid plaque may predict in-stent restenosis (ISR) in coronary arteries. This study included 202 patients who had elective and successful percutaneous coronary intervention (PCI) with bare metal stents in de novo lesions of native coronary arteries for symptomatic coronary artery disease (CAD). Carotid plaque echolucency was assessed by ultrasound with integrated backscatter (IBS) analysis (intima-media IBS value minus adventitia IBS) 1 day before PCI. All patients underwent planned coronary angiography (CAG) at 6 months after PCI, or CAG before 6 months due to acute coronary syndromes. ISR (defined as >50% diameter stenosis) was found in 65 (32%) patients. The calibrated IBS values of carotid plaques were inversely correlated with late luminal loss of the stented lesions. Using multivariate logistic regression analysis, the presence of echolucent carotid plaques (<or=-13.7 dB, arbitrarily determined by an ROC curve) served as an independent predictor of ISR (odds ratio 3.8, 95% CI 1.9-7.3, p=0.01) and target lesion revascularization (n=48) (odds ratio 2.8, 95% CI 1.4-5.7, p=0.01). In conclusion, echolucent carotid plaques with low IBS values were independently and closely associated with ISR in native coronary arteries.
authors.affiliation: Department of Internal Medicine II, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, 1110 Shimokato, Nakakoma-gun, Yamanashi 409-3898, Japan.
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Kitta
authors.forename: Jyun-ei
authors.initials: JE
authors.lastname: Obata
authors.forename: Hajime
authors.initials: H
authors.lastname: Takano
authors.forename: Takamitsu
authors.initials: T
authors.lastname: Nakamura
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Kodama
authors.forename: Daisuke
authors.initials: D
authors.lastname: Fujioka
authors.forename: Yukio
authors.initials: Y
authors.lastname: Saito
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Kawabata
authors.forename: Akira
authors.initials: A
authors.lastname: Mende
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Kobayashi
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Kugiyama
mesh_terms: D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D002339:Carotid Arteries / Q000000981:diagnostic imaging; D002340:Carotid Artery Diseases / Q000000981:diagnostic imaging* / Q000453:epidemiology; D003324:Coronary Artery Disease / Q000453:epidemiology / Q000628:therapy*; D023903:Coronary Restenosis / Q000000981:diagnostic imaging* / Q000453:epidemiology; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008670:Metals; D008875:Middle Aged; D015999:Multivariate Analysis; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012307:Risk Factors; D015607:Stents; D014463:Ultrasonography
chemical_list: D008670:Metals