title: Zuclopenthixol in adults with intellectual disabilities and aggressive behaviours: discontinuation study.
abstract: We investigated the effects of zuclopenthixol on aggressive behaviour in patients with intellectual disabilities by randomly withdrawing it after a 6-week period of open treatment. Of the 49 patients responding to the treatment, 39 took part in a randomised withdrawal trial. The placebo subgroup (n=20) showed more aggressive behaviour as indicated by outcomes observed by external raters on the Modified Overt Aggression Scale than did the continuing subgroup (n=19). The results indicate that discontinuation of zuclopenthixolin this population leads to an increase in aggressive behaviour.
authors.affiliation: Department of Child and Adolescent Psychiatry, University of Rostock, Rostock, Germany. frank.haessler@med.uni-rostock.de
authors.forename: Frank
authors.initials: F
authors.lastname: Haessler
authors.forename: Thomas
authors.initials: T
authors.lastname: Glaser
authors.forename: Manfred
authors.initials: M
authors.lastname: Beneke
authors.forename: Akos F
authors.initials: AF
authors.lastname: Pap
authors.forename: Ralf
authors.initials: R
authors.lastname: Bodenschatz
authors.forename: Olaf
authors.initials: O
authors.lastname: Reis
mesh_terms: D000293:Adolescent; D000328:Adult; D000374:Aggression / Q000187:drug effects* / Q000523:psychology; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D003006:Clopenthixol / Q000627:therapeutic use*; D004311:Double-Blind Method; D006801:Humans; D008607:Intellectual Disability / Q000523:psychology*; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D028761:Withholding Treatment
chemical_list: D014150:Antipsychotic Agents; D003006:Clopenthixol