title: Anti-cytokine autoantibodies are ubiquitous in healthy individuals.
abstract: Anti-cytokine autoantibodies in healthy individuals have been widely reported but the occurrence is variable and inconstant. We hypothesized that cytokine-binding in vivo may explain their variable and infrequent detection. Therefore, we focused on the detection of the cytokine-autoantibody complexes and found that anti-cytokine autoantibody to IL-2, IL-8, tumor necrosis factor-alpha, vascular endothelial growth factor and granulocyte-colony stimulating factor were present in all 15 individuals evaluated, while those to IL-3, osteopontin and macrophage-colony stimulating factor were not detected in anyone. Autoantibodies against IL-4, IL-6, IL-10, and interferon-gamma were variously detected. Thus, we discovered that anti-cytokine autoantibodies to multiple cytokines are ubiquitous in healthy individuals.
authors.affiliation: Bioscience Medical Research Center, Niigata University Medical and Dental Hospital, Niigata 951-8520, Japan.
authors.forename: Masato
authors.initials: M
authors.lastname: Watanabe
authors.forename: Kanji
authors.initials: K
authors.lastname: Uchida
authors.forename: Kazuhide
authors.initials: K
authors.lastname: Nakagaki
authors.forename: Hiroko
authors.initials: H
authors.lastname: Kanazawa
authors.forename: Bruce C
authors.initials: BC
authors.lastname: Trapnell
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Hoshino
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kagamu
authors.forename: Hirohisa
authors.initials: H
authors.lastname: Yoshizawa
authors.forename: Naoto
authors.initials: N
authors.lastname: Keicho
authors.forename: Hajime
authors.initials: H
authors.lastname: Goto
authors.forename: Koh
authors.initials: K
authors.lastname: Nakata
mesh_terms: D000328:Adult; D000918:Antibody Specificity / Q000276:immunology; D001323:Autoantibodies / Q000097:blood* / Q000276:immunology*; D016207:Cytokines / Q000097:blood / Q000276:immunology*; D005260:Female; D006262:Health; D006801:Humans; D008024:Ligands; D008297:Male; D008875:Middle Aged; D042442:Vascular Endothelial Growth Factors / Q000276:immunology
chemical_list: D001323:Autoantibodies; D016207:Cytokines; D008024:Ligands; D042442:Vascular Endothelial Growth Factors