Replication of hepatitis C virus.
Exciting progress has recently been made in understanding the replication of hepatitis C virus, a major cause of chronic hepatitis, liver cirrhosis and hepatocellular carcinoma worldwide. The development of complete cell-culture systems should now enable the systematic dissection of the entire viral lifecycle, providing insights into the hitherto difficult-to-study early and late steps. These efforts have already translated into the identification of novel antiviral targets and the development of new therapeutic strategies, some of which are currently undergoing clinical evaluation.
Moradpour
Darius
D
Division of Gastroenterology and Hepatology, Centre Hospitalier Universitaire Vaudois, University of Lausanne, CH-1011 Lausanne, Switzerland. darius.moradpour@chuv.ch
Penin
François
F
Rice
Charles M
CM
D016174:Hepacivirus / Q000235:genetics / Q000502:physiology*; D006526:Hepatitis C / Q000821:virology; D006801:Humans; D014764:Viral Proteins / Q000737:chemistry / Q000502:physiology; D014776:Virus Cultivation / Q000379:methods; D053586:Virus Internalization; D014779:Virus Replication
D014764:Viral Proteins