title: Efficacy and safety of a very-low-protein diet when postponing dialysis in the elderly: a prospective randomized multicenter controlled study.
abstract: BACKGROUND
  A supplemented very-low-protein diet (sVLPD) seems to be safe when postponing dialysis therapy.
  
  
  METHODS
  Prospective multicenter randomized controlled study designed to assess the noninferiority of diet versus dialysis in 1-year mortality assessed by using intention-to-treat and per-protocol analysis.
  
  
  METHODS
  Italian uremic patients without diabetes older than 70 years with glomerular filtration rate of 5 to 7 mL/min (0.08 to 0.12 mL/s).
  
  
  METHODS
  Randomization to an sVLPD (diet group) or dialysis. The sVLPD is a vegan diet (35 kcal; proteins, 0.3 g/kg body weight daily) supplemented with keto-analogues, amino acids, and vitamins. Patients following an sVLPD started dialysis therapy in the case of malnutrition, intractable fluid overload, hyperkalemia, or appearance of uremic symptoms.
  
  
  METHODS
  Mortality, hospitalization, and metabolic markers.
  
  
  RESULTS
  56 patients were randomly assigned to each group, median follow-up was 26.5 months (interquartile range, 40), and patients in the diet group spent a median of 10.7 months (interquartile range, 11) following an sVLPD. Forty patients in the diet group started dialysis treatment because of either fluid overload or hyperkalemia. There were 31 deaths (55%) in the dialysis group and 28 deaths (50%) in the diet group. One-year observed survival rates at intention to treat were 83.7% (95% confidence interval [CI], 74.5 to 94.0) in the dialysis group versus 87.3% (95% CI, 78.9 to 96.5) in the diet group (log-rank test for noninferiority, P < 0.001; for superiority, P = 0.6): the difference in survival was -3.6% (95% CI, -17 to +10; P = 0.002). The hazard ratio for hospitalization was 1.50 for the dialysis group (95% CI, 1.11 to 2.01; P < 0.01).
  
  
  CONCLUSIONS
  The unblinded nature of the study, exclusion of patients with diabetes, and incomplete enrollment.
  
  
  CONCLUSIONS
  An sVLPD was effective and safe when postponing dialysis treatment in elderly patients without diabetes.
authors.affiliation: Division of Nephrology, Spedali Civili Brescia, Italy. gcbrunori@hotmail.com <gcbrunori@hotmail.com>
authors.forename: Giuliano
authors.initials: G
authors.lastname: Brunori
authors.forename: Battista F
authors.initials: BF
authors.lastname: Viola
authors.forename: Giovanni
authors.initials: G
authors.lastname: Parrinello
authors.forename: Vincenzo
authors.initials: V
authors.lastname: De Biase
authors.forename: Giovanna
authors.initials: G
authors.lastname: Como
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Franco
authors.forename: Giacomo
authors.initials: G
authors.lastname: Garibotto
authors.forename: Roberto
authors.initials: R
authors.lastname: Zubani
authors.forename: Giovanni C
authors.initials: GC
authors.lastname: Cancarini
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D018753:Diet, Protein-Restricted / Q000009:adverse effects*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007676:Kidney Failure, Chronic / Q000178:diet therapy* / Q000401:mortality; D008297:Male; D011446:Prospective Studies; D006435:Renal Dialysis / Q000009:adverse effects* / Q000401:mortality; D015996:Survival Rate; D013997:Time Factors