title: Real-time quantitative automatic assessment of left ventricular ejection fraction and regional wall motion by speckle imaging.
abstract: BACKGROUND
  Echocardiographic assessment of left ventricular function includes calculation of ejection fraction and regional wall motion analysis. Recently, speckle imaging was introduced for quantification of left ventricular function.
  
  
  OBJECTIVE
  To assess LVEF by speckle imaging and compare it with Simpson's method, and to assess the regional LV strain obtained by speckle imaging in relation to conventional echocardiographic scores.
  
  
  METHODS
  Thirty consecutive patients, 28 with regional LV dysfunction, underwent standard echocardiographic evaluation. LV end-diastolic volume, LV end-systolic volume and EF were calculated independently by speckle imaging and Simpson's rule. The regional peak systolic strain presented by speckle imaging as a bull's-eye map was compared with the conventional visual estimate of echo score.
  
  
  RESULTS
  Average EDV obtained by speckle imaging and by Simpson's method was 85.1 vs. 92.7 ml (P = 0.38), average ESV was 49.4 vs. 48.8 ml (P = 0.94), calculated EF was 43.9 vs. 50.5% (P = 0.08). The correlation rate with Simpson's rule was high: 0.92 for EDV, 0.96 for ESV, and 0.89 for EF. The peak systolic strain in two patients without wall motion abnormality was 17.3 +/- 4.7; in normal segments of patients with regional dysfunction, peak systolic strain (13.4 +/- 4.9) was significantly higher than in hypokinetic segments (10.5 +/- 4.5) (P < 0.000001). The strain in hypokinetic segments was significantly higher than in akinetic segments (6.2 +/- 3.6) (P < 0.000001).
  
  
  CONCLUSIONS
  Speckle imaging can be successfully used for the assessment of LV volumes and EF. Bull's-eye strain map, created by speckle imaging, can achieve an accurate real-time segmental wall motion analysis.
authors.affiliation: Department of Cardiology, Assaf Harofeh Medical Center, Zerifin, Israel. marina.leitman@gmail.com
authors.forename: Marina
authors.initials: M
authors.lastname: Leitman
authors.forename: Peter
authors.initials: P
authors.lastname: Lysyansky
authors.forename: Josef
authors.initials: J
authors.lastname: Gurevich
authors.forename: Zvi
authors.initials: Z
authors.lastname: Friedman
authors.forename: Edgar
authors.initials: E
authors.lastname: Sucher
authors.forename: Simcha
authors.initials: S
authors.lastname: Rosenblatt
authors.forename: Edo
authors.initials: E
authors.lastname: Kaluski
authors.forename: Ricardo
authors.initials: R
authors.lastname: Krakover
authors.forename: Therese
authors.initials: T
authors.lastname: Fuchs
authors.forename: Zvi
authors.initials: Z
authors.lastname: Vered
mesh_terms: D004452:Echocardiography / Q000379:methods*; D006801:Humans; D015203:Reproducibility of Results; D012720:Severity of Illness Index; D013318:Stroke Volume / Q000502:physiology*; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D016277:Ventricular Function, Left / Q000502:physiology*