[Characteristics of interaction of adenylate cyclase modulators and phosphoinositide cell signaling systems with lipid langmuir monolayers].
Interaction of two groups of bioregulators, which oppositely affect activity of adenylate cyclase and phosphoinositide cellular signaling systems, with the Langmuir monolayer films made of natural lecithin was studied. Most significant influence on the structural and energy characteristics of lipid monolayers was revealed for the group of bioregulators, which inhibit polyphosphoinositide signaling system or/and activate adenylate cyclase signaling system. It is shown, that using the cluster analysis the bioregulators can be divided into two groups according to general orientation of their action on the considered systems of transduction of a signal.
Liakhov
O M
OM
Prokopenko
V V
VV
Prokopenko
R A
RA
Mohylevych
S Ie
SIe
D000067956:Adenylyl Cyclase Inhibitors; D000262:Adenylyl Cyclases / Q000737:chemistry; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism*; D016000:Cluster Analysis; D004734:Energy Metabolism / Q000187:drug effects; D006801:Humans; D050356:Lipid Metabolism / Q000187:drug effects; D008567:Membranes, Artificial; D008954:Models, Biological; D004364:Pharmaceutical Preparations / Q000008:administration & dosage; D010713:Phosphatidylcholines / Q000737:chemistry; D010716:Phosphatidylinositols / Q000037:antagonists & inhibitors / Q000737:chemistry; D015398:Signal Transduction / Q000187:drug effects
D000067956:Adenylyl Cyclase Inhibitors; D008567:Membranes, Artificial; D004364:Pharmaceutical Preparations; D010713:Phosphatidylcholines; D010716:Phosphatidylinositols; D000262:Adenylyl Cyclases