Spinal atypical teratoid/rhabdoid tumor in a 7-year-old boy.
Reported herein is an unusual case of atypical teratoid/ rhabdoid tumor (AT/RT) of the lumbar spine with an intradural extramedullary location in a 7-year-old boy. Histologically, this tumor contained rhabdoid cells, pale cells, and sickle-shaped embracing cells without primitive neuroectodermal tumor (PNET), mesenchymal or epithelial components. Immunohistochemical staining showed that these tumor cells react positively for epithelial membrane antigen (EMA), vimentin, cytokeratin (AE1/AE3), CD99 and neurofilament protein, but negatively for INI1 antibody. Chromosome 22q deletion was demonstrated on fluorescence in situ hybridization.
Yang
Chii-Shuenn
CS
Department of Pathology, Taichung Veterans General Hospital, College of Medicine, Chung Shan Medical University, Taichung, Taiwan. chii.shuenn@msa.hinet.net
Jan
Yee-Jee
YJ
Wang
John
J
Shen
Chiung-Chyi
CC
Chen
Clayton C C
CC
Chen
Ming
M
D002648:Child; D002872:Chromosome Deletion; D002892:Chromosomes, Human, Pair 22; D017809:Fatal Outcome; D006801:Humans; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D008161:Lumbosacral Region; D008279:Magnetic Resonance Imaging; D008297:Male; D018335:Rhabdoid Tumor / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D013125:Spinal Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D013724:Teratoma / Q000235:genetics / Q000378:metabolism / Q000473:pathology*