Similarities of the neuronal circuit for the induction of fictive vomiting between ferrets and dogs.
Previous studies suggested that the following neuronal circuit participates in the induction of vomiting by afferent vagal stimulation in decerebrated paralyzed dogs: (1) afferent fibers of the vagus nerve, (2) neurons of the solitary nucleus (NTS), (3) neurons of the prodromal sign center near the semicompact part of the nucleus ambiguus (scAMB), (4) neurons of the central pattern generator in the reticular area adjacent to the compact part of nucleus ambiguus (cAMB), (5) respiratory premotor neurons in the caudal medulla, (6) motor neurons of the diaphragm and abdominal muscles. However, the commonality of this neuronal circuit in different species has not yet been clarified. Thus, this study was conducted to clarify this point. This study clarified for the first time that fictive vomiting in decerebrated paralyzed ferrets could be induced by vagal stimulation, and could be identified by centrifugal activity patterns of the phrenic and abdominal muscle nerves. The distributions of c-Fos immunoreactive neurons in the NTS, scAMB and cAMB areas in ferrets that exhibited fictive vomiting were denser than those in ferrets that did not. Application of the nonNMDA receptor antagonist into the 4th ventricle produced the reversible suppression of fictive vomiting. The NK1 receptor immunoreactive puncta were found in the reticular area adjacent to the scAMB. Microinjections of NK1 receptor antagonist into the reticular areas on both sides abolished fictive vomiting. All these results in the ferrets are identical with results previously obtained in dogs and cats. Therefore, this suggests that the above neuronal circuit commonly participates in the induction of emesis in these animal species.
Onishi
Takako
T
Department of Clinical Nutrition, Faculty of Medical Professions, Kawasaki University of Medical Welfare, 288 Matsushima, Kurashiki, Okayama 701-0193, Japan.
Mori
Takashi
T
Yanagihara
Mamoru
M
Furukawa
Naohiro
N
Fukuda
Hiroyuki
H
D000818:Animals; D046028:Canidae / Q000033:anatomy & histology / Q000502:physiology; D004285:Dogs; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D005289:Ferrets / Q000033:anatomy & histology / Q000502:physiology*; D007276:Injections, Intraventricular; D008297:Male; D008526:Medulla Oblongata / Q000033:anatomy & histology / Q000502:physiology*; D008845:Microinjections; D009046:Motor Neurons / Q000502:physiology; D009415:Nerve Net / Q000033:anatomy & histology / Q000502:physiology*; D009434:Neural Pathways / Q000033:anatomy & histology / Q000502:physiology*; D064729:Neurokinin-1 Receptor Antagonists; D010791:Phrenic Nerve / Q000502:physiology; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism; D018040:Receptors, Neurokinin-1 / Q000378:metabolism; D012125:Respiratory Center / Q000502:physiology; D012132:Respiratory Muscles / Q000294:innervation / Q000502:physiology; D012143:Respiratory Physiological Phenomena; D012154:Reticular Formation / Q000502:physiology; D017552:Solitary Nucleus / Q000033:anatomy & histology / Q000502:physiology; D013045:Species Specificity; D014630:Vagus Nerve / Q000033:anatomy & histology / Q000502:physiology*; D017833:Visceral Afferents / Q000033:anatomy & histology / Q000502:physiology; D014839:Vomiting / Q000503:physiopathology*
D018691:Excitatory Amino Acid Antagonists; D064729:Neurokinin-1 Receptor Antagonists; D016760:Proto-Oncogene Proteins c-fos; D018040:Receptors, Neurokinin-1