A case-series of 29 patients with lichen planopilaris: the Cleveland Clinic Foundation experience on evaluation, diagnosis, and treatment.
BACKGROUND
Lichen planopilaris results in scaling, atrophy, and permanent alopecia with scarring and is thought to be autoimmune in origin.


OBJECTIVE
To evaluate the clinical findings of patients with LPP so as to aid in the evaluation and diagnosis of the disease and to review the current effective therapies.


METHODS
We reviewed the medical records of 29 patients with LPP that were seen in the Department of Dermatology at The Cleveland Clinic Foundation between 1992 and 2003.


RESULTS
Good responses in the active perimeter were seen with topical steroids, intralesional steroids, and tetracycline and in the inactive end-stage with hair transplants and scalp reductions.


CONCLUSIONS
This study was limited by being retrospective in nature.


CONCLUSIONS
Although topical high-potency and intralesional corticosteroids remain the mainstay for treatment of LPP, the use of tetracycline in this disease may be more helpful than once thought.
Cevasco
Nathaniel C
NC
Department of Dermatology, The Cleveland Clinic Foundation, OH, USA.
Bergfeld
Wilma F
WF
Remzi
Berna K
BK
de Knott
Haydee Ramirez
HR
D000287:Administration, Topical; D000328:Adult; D000368:Aged; D000505:Alopecia / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D005260:Female; D006801:Humans; D008010:Lichen Planus / Q000150:complications / Q000175:diagnosis* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012536:Scalp Dermatoses / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy*; D013256:Steroids / Q000008:administration & dosage; D044465:White People
D013256:Steroids