[Omics docking for polygenic inheritance tumors].
Omics docking study for polygenic inheritance tumors has become an important strategy in oncology research. This review focuses on the conceptions and technologies of omics, and puts forward the central contents and omics docking for polygenic inheritance tumor to reveal the role of molecular changes at different stages of polygenic inheritance tumor at multidisciplinary and multilayer level. It is a new strategy to explore the mechanism of tumor carcinogenesis, and to regulate the network, key molecules, and drug target by combined biology effects.
Huang
Chen
C
Cancer Research Institute, Central South University, Changsha, China.
Wu
Ming-Hua
MH
Li
Xiao-Ling
XL
Li
Gui-Yuan
GY
D002352:Carrier Proteins / Q000096:biosynthesis / Q000235:genetics; D023281:Genomics / Q000379:methods*; D006023:Glycoproteins / Q000096:biosynthesis / Q000235:genetics; D006801:Humans; D008565:Membrane Proteins / Q000096:biosynthesis / Q000235:genetics; D020412:Multifactorial Inheritance / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism*; D010750:Phosphoproteins / Q000096:biosynthesis / Q000235:genetics; D040901:Proteomics / Q000379:methods*; D025521:Tumor Suppressor Proteins / Q000096:biosynthesis / Q000235:genetics
C485599:BPIFA1 protein, human; D002352:Carrier Proteins; D006023:Glycoproteins; D008565:Membrane Proteins; D010750:Phosphoproteins; C477325:TMEM8B protein, human; D025521:Tumor Suppressor Proteins; C469867:UBAP1 protein, human