The effect of Cyclosporine A on cardiomyocytes differentiation.
Cyclosporine A (CsA) is a powerful immunosuppressive drug which significantly improved the success of organ transplantation; however, the major limiting factors for the drug's clinical use are its long and short term adverse effects. The present study was conducted to examine, in a dose-dependent manner, in a model of cardiogenesis, the effect of CsA on cardiomyocytes differentiation.
Paslaru
Liliana
L
Carol Davila University of Medicine and Pharmacy, Department of Biochemistry, Fundeni Clinical Institute, 258 Fundeni str., Bucharest, Romania. lilianaliviapaslaru@yahoo.fr
Davidson
Sean
S
Popescu
Irinel
I
Morange
Michel
M
D000199:Actins / Q000378:metabolism; D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects*; D045744:Cell Line, Tumor; D016572:Cyclosporine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006360:Heat-Shock Proteins / Q000378:metabolism; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D051379:Mice; D018832:Molecular Chaperones; D032383:Myocytes, Cardiac / Q000187:drug effects*; D009363:Neoplasm Proteins / Q000378:metabolism
D000199:Actins; D006360:Heat-Shock Proteins; C486113:Hsbp1 protein, mouse; D007166:Immunosuppressive Agents; D018832:Molecular Chaperones; D009363:Neoplasm Proteins; D016572:Cyclosporine