A new cytotoxic prenylated chalcone from Sophora flavescens.
We have isolated a new prenylated chalcone from the roots of Sophora flavescens (Leguminosae). We determined that structure of this compound is 7,9,2',4'-tetrahydroxy-8-isopentenyl-5-methoxychalcone (1) on the basis of spectroscopic analysis (1D and 2D NMR data). Compound 1 exhibited potent cytotoxicity against human acute promyelocytic (HL60), mouse lymphocytic (L1210) and human histiocytic (U937) leukemia cells.
Lee
Jae Hyeok
JH
Department of Oriental Pharmaceutical Development, Nambu University, Gwangju, Korea.
Baek
Nam-In
NI
Kim
Sung-Hoon
SH
Park
Hee Wook
HW
Yang
Jae Heon
JH
Lee
Jeong Joo
JJ
Kim
Seong Jin
SJ
Jeong
Seung il
Si
Oh
Chan-Ho
CH
Lee
Kyu-Hee
KH
Kim
Dae Keun
DK
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D047188:Chalcones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D017368:Protein Prenylation; D029909:Sophora / Q000737:chemistry*
D000972:Antineoplastic Agents, Phytogenic; D047188:Chalcones