title: Effectiveness of kamishoyosan for premenstrual dysphoric disorder: open-labeled pilot study.
abstract: The purpose of the present paper was to investigate the efficacy of kamishoyosan (TJ-24), a traditional Japanese herbal formula (kampo), for outpatients with premenstrual dysphoric disorder (PMDD) as an alternative treatment. Thirty patients with PMDD were treated with TJ-24 for six menstrual cycles. Nineteen patients (63.3%) had >50% improvement in the total score of the Hamilton Depression Rating Scale (HAM-D) Scale (17 items) in the late luteal phase. Fourteen patients (46.7%) went into remission (total HAM-D score <7). In the present study many patients with PMDD were successfully treated with TJ-24.
authors.affiliation: Department of Psychiatry, Tokyo Women's Medical University, Medical Center East, Tokyo, Japan. yamadaps@dnh.twmu.ac.jp
authors.forename: Kazuo
authors.initials: K
authors.lastname: Yamada
authors.forename: Shigenobu
authors.initials: S
authors.lastname: Kanba
mesh_terms: D000293:Adolescent; D000328:Adult; D003863:Depression / Q000188:drug therapy / Q000209:etiology / Q000523:psychology; D004365:Drugs, Chinese Herbal / Q000009:adverse effects* / Q000627:therapeutic use*; D005260:Female; D019584:Hot Flashes / Q000188:drug therapy; D006801:Humans; D008875:Middle Aged; D010865:Pilot Projects; D011293:Premenstrual Syndrome / Q000188:drug therapy* / Q000523:psychology; D011569:Psychiatric Status Rating Scales
chemical_list: D004365:Drugs, Chinese Herbal; C103354:kamisyoyo san