Quinolone alkaloids from evodiae fructus and their inhibitory effects on monoamine oxidase.
1-Methyl-2-undecyl-4(1H)-quinolone (1) was previously isolated as a selective MAO-B inhibitor from the Evodiae Fructus. Further bioassay-guided purification led to the identification of five known quinolone alkaloids, 1-methyl-2-nonyl-4(1H)-quinolone (2), 1-methyl-2-[(Z)-6-undecenyl]-4(1H)-quinolone (3), evocarpine (4), 1-methyl-2-[(6Z,9Z)-6,9-pentadecadienyl]-4(1H)-quinolone (5), and dihydroevocarpine (6). All the isolates showed more potent inhibitory effects against MAO-B compared to MAO-A. The most MAO-B selective compound 5 among the isolates inhibited MAO-B in a competitive manner, according to kinetic analyses by Lineweaver-Burk reciprocal plots.
Han
Xiang Hua
XH
College of Pharmacy, Chungbuk National University, Cheongju, Korea.
Hong
Seong Su
SS
Lee
Dongho
D
Lee
Jung Joon
JJ
Lee
Moon Soon
MS
Moon
Dong-Cheul
DC
Han
Kun
K
Oh
Ki-Wan
KW
Lee
Myung Koo
MK
Ro
Jai Seup
JS
Hwang
Bang Yeon
BY
D000470:Alkaloids / Q000302:isolation & purification* / Q000494:pharmacology; D032086:Evodia / Q000737:chemistry*; D008996:Monoamine Oxidase Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology; D015363:Quinolones / Q000302:isolation & purification* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000470:Alkaloids; D008996:Monoamine Oxidase Inhibitors; D015363:Quinolones