title: MDR1 polymorphism influences the outcome of multiple myeloma patients.
abstract: The multidrug resistance gene (MDR1) has been reported to be an additional prognostic factor in acute myeloid leukaemia patients. This study evaluated the prognostic role of MDR1 in the outcome of 115 multiple myeloma patients treated with DAV (dexamethasone, doxorubicin [adryamicin] and vincristine) regimen followed by autologous transplantation. In particular, when investigating the C3435T polymorphism, a prognostic value of MDR1 genotypes for overall survival (OS) was observed. Our data suggested a longer OS for patients with C/T and T/T genotypes (log-rank test, P = 0.02) compared with patients with C/C genotype.
authors.affiliation: Department of Oncology, Transplants and Advanced Technologies, Section of Hematology, Pisa University, Pisa, Italy. ga.buda@libero.it
authors.forename: Gabriele
authors.initials: G
authors.lastname: Buda
authors.forename: Valentina
authors.initials: V
authors.lastname: Maggini
authors.forename: Sara
authors.initials: S
authors.lastname: Galimberti
authors.forename: Alessandro
authors.initials: A
authors.lastname: Martino
authors.forename: Nicola
authors.initials: N
authors.lastname: Giuliani
authors.forename: Fortunato
authors.initials: F
authors.lastname: Morabito
authors.forename: Giovenzio
authors.initials: G
authors.lastname: Genestreti
authors.forename: Pasquale
authors.initials: P
authors.lastname: Iacopino
authors.forename: Vittorio
authors.initials: V
authors.lastname: Rizzoli
authors.forename: Roberto
authors.initials: R
authors.lastname: Barale
authors.forename: Anna M
authors.initials: AM
authors.lastname: Rossi
authors.forename: Mario
authors.initials: M
authors.lastname: Petrini
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000235:genetics; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003907:Dexamethasone / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D019008:Drug Resistance, Neoplasm; D005260:Female; D019450:Genes, MDR; D006801:Humans; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000188:drug therapy / Q000235:genetics* / Q000401:mortality; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D016019:Survival Analysis; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D014750:Vincristine; D003907:Dexamethasone; D004317:Doxorubicin