Ketamine-associated ulcerative cystitis: a new clinical entity.
OBJECTIVE
Ketamine hydrochloride is an N-methyl-D-aspartic acid receptor antagonist used as an anesthetic agent in human and veterinary procedures. Increasingly, it is being used as a recreational drug. Recreational ketamine users have anecdotally reported increased lower urinary tract symptoms while using the substance.


METHODS
We describe a series of 9 patients, all of whom were daily ketamine users, who presented with severe dysuria, frequency, urgency, and gross hematuria. Investigations, including urine culture, microscopy, and cytology, in addition to computed tomography, cystoscopy, and bladder biopsies, were performed to identify a relationship between recreational ketamine use and these symptoms.


RESULTS
The urine cultures were sterile in all cases. Computed tomography revealed marked thickening of the bladder wall, a small capacity, and perivesicular stranding, consistent with severe inflammation. At cystoscopy, all patients had severe ulcerative cystitis. Biopsies in 4 patients revealed epithelial denudation and inflammation with a mild eosinophilic infiltrate. Cessation of ketamine use, with the addition of pentosan polysulfate, appeared to provide some symptomatic relief.


CONCLUSIONS
This case series has described a new clinical entity of severe ulcerative cystitis as a result of chronic ketamine use. As illicit ketamine becomes more easily available, ulcerative cystitis and potential long-term bladder sequelae related to its use may be a more prevalent problem confronting urologists.
Shahani
Rohan
R
Department of Surgery, St. Michael's Hospital and University of Toronto, Toronto, Ontario, Canada.
Streutker
Cathy
C
Dickson
Brendan
B
Stewart
Robert J
RJ
D000328:Adult; D001707:Biopsy, Needle; D003556:Cystitis / Q000139:chemically induced* / Q000473:pathology*; D003558:Cystoscopy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007649:Ketamine / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D010426:Pentosan Sulfuric Polyester / Q000008:administration & dosage / Q000009:adverse effects*; D012008:Recurrence; D012494:Sampling Studies; D012720:Severity of Illness Index; D014057:Tomography, X-Ray Computed; D014456:Ulcer / Q000139:chemically induced / Q000473:pathology; D016482:Urinalysis
D010426:Pentosan Sulfuric Polyester; D007649:Ketamine