Cytotoxic effects of C-glycosides in HOS and HeLa cell lines.
Fifty-two C-glycosides were synthesized and their in-vitro antiproliferative activity screened against human cervical carcinoma (HeLa) and osteosarcoma (HOS) cell lines. Nine of them had growth inhibitions (GI(50) values) below 10 microM, the C-glucopyranoside 38 being the most active against HeLa (5.4 microM) and the dichlorocyclopropyl derivative 42 against HOS (1.6 microM). Some preliminary structure-activity relationships were established.
Sanhueza
Carlos A
CA
Instituto Universitario de Bio-Orgánica Antonio González, Departamento de Química Orgánica, Universidad de La Laguna, La Laguna, Tenerife, Spain.
Mayato
Carlos
C
Machín
Rubén P
RP
Padrón
José M
JM
Dorta
Rosa L
RL
Vázquez
Jesús T
JT
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry*; D001859:Bone Neoplasms / Q000188:drug therapy*; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D004354:Drug Screening Assays, Antitumor; D006027:Glycosides / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D008956:Models, Chemical; D012516:Osteosarcoma / Q000188:drug therapy*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D006027:Glycosides