title: Preparation of floating microspheres for fish farming.
abstract: The aim of this study was to develop floating microspheres with practical applications to fish farming. Each microsphere with a central hollow cavity was prepared using a solvent diffusion and evaporation method with Eudragit E100. Various manufacturing parameters were investigated by single factor method. The macrolide antibiotic josamycin was selected as a model drug. The loading efficiency of the drug in the microspheres was 64.7%. In the release study, virtually none of the drug was released into the fresh water whereas the entire drug was released from the josamycin-loaded microspheres into the simulated gastric fluid of rainbow trout (pH 2.7). The buoyancy was excellent with approximately 90% of the microspheres still floating after 24h.
authors.affiliation: BK21 Project Team, College of Pharmacy, Chosun University, 375 Seoseok-dong, Dong-gu, Gwangju 501-759, Republic of Korea.
authors.forename: Pushp R
authors.initials: PR
authors.lastname: Nepal
authors.forename: Myung-Kwan
authors.initials: MK
authors.lastname: Chun
authors.forename: Hoo-Kyun
authors.initials: HK
authors.lastname: Choi
mesh_terms: D000179:Acrylates / Q000737:chemistry*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D004058:Diffusion; D004337:Drug Carriers; D004339:Drug Compounding; D004355:Drug Stability; D005398:Fisheries / Q000379:methods*; D005618:Fresh Water / Q000737:chemistry; D005750:Gastric Juice / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D015570:Josamycin / Q000737:chemistry*; D007700:Kinetics; D008863:Microspheres; D017686:Oncorhynchus mykiss; D011108:Polymers / Q000737:chemistry*; D016062:Porosity; D012995:Solubility; D012997:Solvents / Q000737:chemistry*; D013499:Surface Properties; D013678:Technology, Pharmaceutical / Q000379:methods; D014835:Volatilization
chemical_list: D000179:Acrylates; D000900:Anti-Bacterial Agents; D004337:Drug Carriers; C477020:Eudragit E100; D011108:Polymers; D012997:Solvents; D015570:Josamycin