title: Inhibition of "de novo" plaque formation with 0.12% chlorhexidine spray compared to 0.2% spray and 0.2% chlorhexidine mouthwash.
abstract: BACKGROUND
  Chlorhexidine (CHX) is widely accepted as the most effective product in the control of supragingival plaque. It is available in different delivery devices. The aim of this study was to test whether 0.12% CHX spray was as effective as 0.2% CHX spray and 0.2% CHX mouthwash in a 3-day "de novo" plaque formation model.
  
  
  METHODS
  Ninety volunteers were enrolled into a single-blind, randomized, three-group parallel study. They received a thorough dental prophylaxis prior to the test period. Subjects were divided randomly into three equal groups. They were requested to refrain from all forms of mechanical oral hygiene and instructed to use only their assigned product during the 3-day experimental period. After 3 days, the plaque growth was assessed using the Quigley and Hein plaque index (Q&H PI) at six sites per tooth.
  
  
  RESULTS
  After 3 days, the CHX mouthwash group had a mean Q&H PI of 1.17 compared to 1.41 for the 0.2% CHX spray and 1.49 for the 0.12% CHX spray. The difference between the mouthwash and the two sprays was statistically significant, whereas the two sprays did not differ significantly from each other.
  
  
  CONCLUSIONS
  Within the limitations of this 3-day "de novo" plaque formation study, the two sprays were not as effective as the mouthwash in plaque inhibition. No significant difference was found between the two sprays. To achieve the same effectiveness as a mouthwash, a higher dose (number of puffs) of CHX spray may be necessary.
authors.affiliation: Department of Periodontology, Academic Center for Dentistry Amsterdam, Amsterdam, The Netherlands.
authors.forename: J E
authors.initials: JE
authors.lastname: Stoeken
authors.forename: P A
authors.initials: PA
authors.lastname: Versteeg
authors.forename: N A M
authors.initials: NA
authors.lastname: Rosema
authors.forename: M F
authors.initials: MF
authors.lastname: Timmerman
authors.forename: U
authors.initials: U
authors.lastname: van der Velden
authors.forename: G A
authors.initials: GA
authors.lastname: van der Weijden
mesh_terms: D000293:Adolescent; D000328:Adult; D000336:Aerosols; D002710:Chlorhexidine / Q000008:administration & dosage*; D003773:Dental Plaque / Q000517:prevention & control*; D003774:Dental Plaque Index; D016503:Drug Delivery Systems / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D009067:Mouthwashes / Q000008:administration & dosage*; D012016:Reference Values; D018709:Statistics, Nonparametric; D016896:Treatment Outcome
chemical_list: D000336:Aerosols; D009067:Mouthwashes; D002710:Chlorhexidine