title: Pharmacokinetics of Gastrodin in rat plasma and CSF after i.n. and i.v.
abstract: The pharmacokinetic behavior of Gastrodin in rat plasma and cerebrospinal fluid (CSF) after intranasal and intravenous administration (50mg kg(-1)) was investigated. Intranasal administration of Gastrodin provided a comparable AUC in CSF compared with the intravenous administration. But Gastrodin level in plasma was very low. The ratios of AUC values of intranasal to intravenous administration were 8.85% and 105.5% in plasma and CSF, respectively. The drug targeting index (DTI) was 12.34. In conclusion, intranasal administration of Gastrodin is a promising alternative to traditional administration. Olfactory mucosa did present another pathway for transport Gastrodin to the brain.
authors.affiliation: Department of Pharmaceutical Analysis and Drug Metabolism, College of Pharmaceutical Sciences, Zi Jin Gang Campus, Zhejiang University, Hangzhou, Zhejiang 310058, PR China. wangqiao-1@163.com
authors.forename: Qiao
authors.initials: Q
authors.lastname: Wang
authors.forename: Guoshen
authors.initials: G
authors.lastname: Chen
authors.forename: Su
authors.initials: S
authors.lastname: Zeng
mesh_terms: D000281:Administration, Intranasal; D000818:Animals; D019540:Area Under Curve; D001592:Benzyl Alcohols / Q000008:administration & dosage* / Q000097:blood / Q000134:cerebrospinal fluid / Q000493:pharmacokinetics*; D001682:Biological Availability; D001812:Blood-Brain Barrier / Q000378:metabolism*; D002491:Central Nervous System Agents / Q000008:administration & dosage* / Q000097:blood / Q000134:cerebrospinal fluid / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid; D005960:Glucosides / Q000008:administration & dosage* / Q000097:blood / Q000134:cerebrospinal fluid / Q000493:pharmacokinetics*; D007275:Injections, Intravenous; D008297:Male; D009831:Olfactory Mucosa / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D015203:Reproducibility of Results
chemical_list: D001592:Benzyl Alcohols; D002491:Central Nervous System Agents; D005960:Glucosides; C045345:gastrodin