title: Integrated evaluation of hypertensive patients with cardiovascular magnetic resonance.
abstract: BACKGROUND
  Hypertension causes cardiac morbidity and premature mortality. Accurate evaluation to exclude potentially curable causes is important. Cardiovascular Magnetic Resonance and Magnetic Resonance Angiography (CMR/CE-MRA) provide an integrated approach to the assessment of hypertensive patients - a single study can identify certain secondary causes and assess left ventricular (LV) mass and function. The aim of this study was to prospectively evaluate the feasibility of CMR/CE-MRA to define LV dimensions and exclude some secondary causes in a selected group of hypertensives.
  
  
  RESULTS
  Fifty-three hypertensives (46+/-17 years, 18 females) were prospectively studied (early onset hypertension, n=17; drug resistant hypertension, n=23; hypertension with increased creatinine at baseline/after ACEi, n=12; hypertension with peripheral vessel disease, n=1). Study protocol included assessment of LV and aorta, imaging of adrenals and 3D CE-MRA of aorta and renal arteries. Significant abnormalities were found in 13 patients (25%) - renal artery stenosis (n=8), aortic coarctation (n=4), adrenal mass (n=1). Mean LV mass index was increased compared with matched controls. LV systolic dysfunction was found in 9 patients.
  
  
  CONCLUSIONS
  CMR/CE-MRA provides comprehensive evaluation of hypertensive patients and could allow for a unique integrated approach with assessment of LV dimensions as well as detection of some secondary causes.
authors.affiliation: Magnetic Resonance Unit, ERESA-Hospital Arnau de Vilanova, Valencia, Spain.
authors.forename: Alicia M
authors.initials: AM
authors.lastname: Maceira
authors.forename: Sanjay K
authors.initials: SK
authors.lastname: Prasad
authors.forename: Dudley J
authors.initials: DJ
authors.lastname: Pennell
authors.forename: Raad H
authors.initials: RH
authors.lastname: Mohiaddin
mesh_terms: D000236:Adenoma / Q000175:diagnosis; D000310:Adrenal Gland Neoplasms / Q000175:diagnosis; D000328:Adult; D001017:Aortic Coarctation / Q000175:diagnosis; D050197:Atherosclerosis / Q000175:diagnosis; D016022:Case-Control Studies; D003287:Contrast Media; D003404:Creatinine / Q000032:analysis; D004351:Drug Resistance; D005240:Feasibility Studies; D005260:Female; D019786:Gadolinium DTPA; D006352:Heart Ventricles / Q000473:pathology; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology*; D017379:Hypertrophy, Left Ventricular / Q000503:physiopathology; D021621:Imaging, Three-Dimensional; D019028:Magnetic Resonance Imaging, Cine; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012078:Renal Artery Obstruction / Q000175:diagnosis; D013599:Systole / Q000502:physiology; D018487:Ventricular Dysfunction, Left / Q000503:physiopathology; D020257:Ventricular Remodeling / Q000502:physiology
chemical_list: D003287:Contrast Media; D003404:Creatinine; D019786:Gadolinium DTPA