title: The significance of c-erbB-2 overexpression and p53 expression in patients with axillary lymph node--negative breast cancer: a tissue microarray study.
abstract: We conducted this study to examine whether the expression of c-erbB-2 and p53 is the prognostic indicator for patients with early-stage breast cancer in which axillary lymph node metastasis is absent. We examined 326 patients with early-stage breast cancer in which axillary lymph node metastasis is absent. Tissue microarrays were constructed. Following this, immunohistochemical staining was done for estrogen receptor (ER), progesterone receptor (PR), c-erbB2, and p53. The results were as follows: (1) expression of c-erbB-2 was correlated with other clinicopathologic factors (eg, patient's age, presence of menopause, tumor size, histologic and nuclear grade, and presence of hormone receptors such as ER and PR); and (2) expression of p53 was correlated with survival rate, patient's age, presence of menopause, and tumor size. However, these results were not statistically significant. In conclusion, our results indicate that expression of c-erbB-2 and p53 did not have any prognostic value in patients with early-stage breast cancer in which axillary lymph node metastasis is absent.
authors.affiliation: Department of Surgery, Sungkyunkwan University School of Medicine, Seoul, Korea. drkoss@skku.edu
authors.forename: Seung-Sang
authors.initials: SS
authors.lastname: Ko
authors.forename: Youn-Sun
authors.initials: YS
authors.lastname: Na
authors.forename: Chan-Seok
authors.initials: CS
authors.lastname: Yoon
authors.forename: Ji-Young
authors.initials: JY
authors.lastname: Park
authors.forename: Hye-Sun
authors.initials: HS
authors.lastname: Kim
authors.forename: Min-Hee
authors.initials: MH
authors.lastname: Hur
authors.forename: Hae-Kyung
authors.initials: HK
authors.lastname: Lee
authors.forename: Yi-Kyung
authors.initials: YK
authors.lastname: Chun
authors.forename: Sung-Soo
authors.initials: SS
authors.lastname: Kang
authors.forename: Byeong-Woo
authors.initials: BW
authors.lastname: Park
authors.forename: Jee-Hyun
authors.initials: JH
authors.lastname: Lee
mesh_terms: D000328:Adult; D001365:Axilla; D014408:Biomarkers, Tumor / Q000378:metabolism; D001943:Breast Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D003131:Combined Modality Therapy; D005260:Female; D019084:Fluorescent Antibody Technique, Indirect; D006801:Humans; D007124:Immunoenzyme Techniques; D008198:Lymph Nodes; D008207:Lymphatic Metastasis; D008875:Middle Aged; D011379:Prognosis; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism*; D012189:Retrospective Studies; D015996:Survival Rate; D046888:Tissue Array Analysis; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; D018719:Erb-b2 Receptor Tyrosine Kinases; D016159:Tumor Suppressor Protein p53