Fear conditioning increases NREM sleep.
To understand the role that sleep may play in memory storage, the authors investigated how fear conditioning affects sleep-wake states by performing electroencephalographic (EEG) and electromyographic recordings of C57BL/6J mice receiving fear conditioning, exposure to conditioning stimuli, or immediate shock treatment. This experimental design allowed us to examine the effects of associative learning, presentation of the conditioning stimuli, and presentation of the unconditioned stimuli on sleep-wake states. During the 24 hr after training, fear-conditioned mice had approximately 1 hr more of nonrapid-eye-movement (NREM) sleep and less wakefulness than mice receiving exposure to conditioning stimuli or immediate shock treatment. Mice receiving conditioning stimuli had more delta power during NREM sleep, whereas mice receiving fear conditioning had less theta power during rapid-eye-movement sleep. These results demonstrate that a single trial of fear conditioning alters sleep-wake states and EEG oscillations over a 24-hr period, supporting the idea that sleep is modified by experience and that such changes in sleep-wake states and EEG oscillations may play a role in memory consolidation.
Hellman
Kevin
K
Neuroscience Graduate Group, University of Pennsylvania, Philadelphia, PA 19104-6084, USA.
Abel
Ted
T
D000818:Animals; D003213:Conditioning, Psychological / Q000502:physiology*; D003627:Data Interpretation, Statistical; D003700:Delta Rhythm; D004569:Electroencephalography; D004576:Electromyography; D004597:Electroshock; D005239:Fear / Q000523:psychology*; D008297:Male; D008568:Memory / Q000502:physiology; D051379:Mice; D008810:Mice, Inbred C57BL; D017286:Polysomnography; D012890:Sleep / Q000502:physiology*; D012895:Sleep, REM / Q000502:physiology; D013826:Theta Rhythm; D014851:Wakefulness / Q000502:physiology