ALK-mediated Na+/H+ exchanger-dependent intracellular alkalinization: does it matter for oncogenesis?
In this study we investigated the relevance of the oncogenic protein NPM-ALK in regulating cellular pH (pHi) through the modulation of Na+/H+ exchanger 1 (NHE1)-activity and the consequences of pHi pharmacological manipulation in cells expressing NPM-ALK.
Turturro
Francesco
F
Driscoll
Michael
M
Friday
Ellen
E
Welbourne
Tomas
T
D000409:Alanine / Q000032:analysis; D000641:Ammonia / Q000032:analysis; D000818:Animals; D002455:Cell Division; D045744:Cell Line, Tumor / Q000378:metabolism; D002471:Cell Transformation, Neoplastic / Q000378:metabolism*; D002839:Chromans / Q000494:pharmacology*; D017077:Culture Media, Conditioned / Q000737:chemistry; D004354:Drug Screening Assays, Antitumor; D018698:Glutamic Acid / Q000378:metabolism; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007424:Intracellular Fluid / Q000737:chemistry*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000473:pathology*; D051379:Mice; D041681:NIH 3T3 Cells / Q000187:drug effects / Q000648:ultrastructure; D011505:Protein-Tyrosine Kinases / Q000235:genetics / Q000502:physiology*; D017923:Sodium-Hydrogen Exchangers / Q000037:antagonists & inhibitors / Q000502:physiology*; D045162:Thiazolidinediones / Q000494:pharmacology*; D014162:Transfection; D000077288:Troglitazone
D002839:Chromans; D017077:Culture Media, Conditioned; D017923:Sodium-Hydrogen Exchangers; D045162:Thiazolidinediones; D018698:Glutamic Acid; D000641:Ammonia; C107023:p80(NPM-ALK) protein; D011505:Protein-Tyrosine Kinases; D000077288:Troglitazone; D000409:Alanine