title: Pelvic and para-aortic lymphadenectomy in patients with endometrioid adenocarcinoma of the endometrium.
abstract: BACKGROUND
  The purpose is to determine the rate of lymph node metastases in women with endometrioid adenocarcinoma of the endometrium (EAE) undergoing systematic lymphadenectomy.
  
  
  METHODS
  Patients (349) underwent a complete pelvic and para-aortic lymphadenectomy from caudal to the median circumflex to the level of the renal vessels.
  
  
  RESULTS
  Grade 1 tumors accounted for 32.7% of the tumors and 31.0% of the positive nodes, grade 2 accounted for 47.3% of the tumors (37.9% of positive nodes), and grade 3 accounted for 20.1% of the tumors and 31.0% of the positive nodes (P>0.05). Positive nodes were found in 15.8% of grade 1 tumors, 13.3% of grade 2 tumors and 25.7% of grade 3 tumors (P>0.05). Isolated para-aortic involvement without pelvic nodal involvement occurred in 29% of patients with positive nodes.
  
  
  CONCLUSIONS
  When complete lymphadenectomies are performed in EAE, positive lymph nodes (including isolated para-aortic lymph nodes) are common in all grades.
authors.affiliation: Indiana Women's Oncology, St. Vincent Hospitals, Indianapolis, Indiana, USA. jgeisler@indianawomensoncology.com
authors.forename: J P
authors.initials: JP
authors.lastname: Geisler
authors.forename: G C
authors.initials: GC
authors.lastname: Linnemeier
authors.forename: K J
authors.initials: KJ
authors.lastname: Manahan
mesh_terms: D000230:Adenocarcinoma / Q000453:epidemiology / Q000473:pathology* / Q000601:surgery; D016889:Endometrial Neoplasms / Q000453:epidemiology / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D015994:Incidence; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis / Q000473:pathology*; D010220:Para-Aortic Bodies; D010388:Pelvis; D012189:Retrospective Studies