Multilevel regulation of growth rate in yeast revealed using systems biology.
The effect of changing growth rates on the transcriptome, proteome and metabolome has been systematically studied. Measurements made under varying nutrient conditions, corresponding to biochemical pathways that correlate primarily with growth rate, reveal a central role for mitochondrial metabolism and the TOR (target of rapamycin) signaling pathway.
Ramanathan
Arvind
A
The Broad Institute of Harvard & MIT, Chemical Biology Program, 7 Cambridge Center, Cambridge, MA 02142, USA.
Schreiber
Stuart L
SL
D020869:Gene Expression Profiling; D015966:Gene Expression Regulation, Fungal / Q000502:physiology*; D008928:Mitochondria / Q000235:genetics / Q000378:metabolism; D011494:Protein Kinases / Q000235:genetics / Q000378:metabolism; D020543:Proteome; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000254:growth & development*; D015398:Signal Transduction; D049490:Systems Biology / Q000379:methods*; D058570:TOR Serine-Threonine Kinases
D020543:Proteome; D011494:Protein Kinases; D058570:TOR Serine-Threonine Kinases