title: Isolation and structure of platencin: a FabH and FabF dual inhibitor with potent broad-spectrum antibiotic activity.
authors.affiliation: Merck Research Laboratories, P. O. Box 2000, Rahway, New Jersey 07065, USA. Hiranthi_jayasuriya@merck.com
authors.forename: Hiranthi
authors.initials: H
authors.lastname: Jayasuriya
authors.forename: Kithsiri B
authors.initials: KB
authors.lastname: Herath
authors.forename: Chaowei
authors.initials: C
authors.lastname: Zhang
authors.forename: Deborah L
authors.initials: DL
authors.lastname: Zink
authors.forename: Angela
authors.initials: A
authors.lastname: Basilio
authors.forename: Olga
authors.initials: O
authors.lastname: Genilloud
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: Diez
authors.forename: Francisca
authors.initials: F
authors.lastname: Vicente
authors.forename: Ignacio
authors.initials: I
authors.lastname: Gonzalez
authors.forename: Oscar
authors.initials: O
authors.lastname: Salazar
authors.forename: Fernando
authors.initials: F
authors.lastname: Pelaez
authors.forename: Richard
authors.initials: R
authors.lastname: Cummings
authors.forename: Sookhee
authors.initials: S
authors.lastname: Ha
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.forename: Sheo B
authors.initials: SB
authors.lastname: Singh
mesh_terms: D015099:3-Oxoacyl-(Acyl-Carrier-Protein) Synthase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D000627:Aminophenols / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D011083:Polycyclic Compounds / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000201:enzymology
chemical_list: D000627:Aminophenols; D000900:Anti-Bacterial Agents; D004791:Enzyme Inhibitors; D011083:Polycyclic Compounds; D015099:3-Oxoacyl-(Acyl-Carrier-Protein) Synthase; C520340:platencin