Effective treatment of experimental autoimmune neuritis with Fc fragment of human immunoglobulin.
IV immunoglobulin (IVIg) and its Fc fragment proved effective in preventing further progression of experimental autoimmune neuritis (EAN) in the rat induced by whole bovine peripheral nerve myelin and shortening disease duration. This effectiveness was associated with significant differences in electrophysiological parameters including less prolongation of somatosensory evoked potential (S wave) latencies, better maintained S wave amplitudes, less reduction of distal motor nerve conduction velocity, and better maintained amplitudes of compound muscle action potentials of dorsal foot muscles after stimulation at ankle and hip. Moreover, treatment with IVIg and Fc fragments resulted in less extensive inflammation and demyelination in nerve roots evidenced by significantly lower histological grades. The current study provides direct evidence for the first time that Fc fraction of IVIg is the effective component in the treatment of rat EAN.
Lin
Hsin Hsin
HH
Department of Medicine, The University of Sydney, Sydney, Australia. hhlin521@hotmail.com
Wang
Min Xia
MX
Spies
Judith M
JM
Pollard
John D
JD
D000200:Action Potentials / Q000187:drug effects / Q000528:radiation effects; D000818:Animals; D001835:Body Weight / Q000187:drug effects / Q000502:physiology; D004195:Disease Models, Animal; D004576:Electromyography; D005260:Female; D006801:Humans; D007141:Immunoglobulin Fc Fragments / Q000627:therapeutic use*; D007155:Immunologic Factors / Q000627:therapeutic use*; D018482:Muscle, Skeletal / Q000187:drug effects / Q000503:physiopathology; D009431:Neural Conduction / Q000187:drug effects / Q000528:radiation effects; D009444:Neuritis, Autoimmune, Experimental / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D051381:Rats; D011917:Rats, Inbred Lew; D011930:Reaction Time; D012584:Sciatic Nerve / Q000503:physiopathology; D013126:Spinal Nerve Roots / Q000473:pathology; D013997:Time Factors
D007141:Immunoglobulin Fc Fragments; D007155:Immunologic Factors