Discovery of new peptides from old prohormones: insights for energy balance and beyond.
A complex network of peptide hormones secreted from the gut, adipose tissue, the brain, and other tissues regulate energy balance. Intensive investigation has uncovered the role of many of the major players in energy balance. However, many of these peptide hormones are derived from precursor proteins whose in vivo processing have not been fully studied. In this review we highlight the importance of fully understanding the processing of prohormones and highlight a particular case of why this is important with the recent discovery of the peptide obestatin.
Mulcahy
Lawrence R
LR
Division of Endocrinology, Department of Medicine, Brown Medical School/Rhode Island Hospital, Brown University, Providence, RI 02903, USA.
Nillni
Eduardo A
EA
D004734:Energy Metabolism; D054439:Ghrelin; D006728:Hormones / Q000378:metabolism*; D036361:Peptide Hormones / Q000378:metabolism; D010455:Peptides / Q000378:metabolism*; D011333:Pro-Opiomelanocortin / Q000378:metabolism; D011499:Protein Processing, Post-Translational; D013973:Thyrotropin-Releasing Hormone / Q000378:metabolism
D054439:Ghrelin; D006728:Hormones; D036361:Peptide Hormones; D010455:Peptides; C505799:obestatin, human; D013973:Thyrotropin-Releasing Hormone; D011333:Pro-Opiomelanocortin