title: Suprathel, a new skin substitute, in the management of donor sites of split-thickness skin grafts: results of a clinical study.
abstract: OBJECTIVE
  A prospective, randomized, two center clinical study was conducted to evaluate the impact on wound healing of Suprathel in donor sites of split-thickness skin grafts. Suprathel represents an absorbable, synthetic wound dressing with properties of natural epithelium.
  
  
  METHODS
  22 burn patients who were treated with split-thickness skin grafts, and with a mean age of 39.6 years were included in the study. Donor sites of skin grafts were randomly selected; partly treated with Jelonet and partly treated with Suprathel. First gauze change was carried out the fifth day postoperatively followed by regular wound inspection until complete re-epithelization. The study focused on patient pain score, healing time, analysis of wound bed, ease of care, and treatment costs.
  
  
  RESULTS
  There was no significant difference between the two materials tested regarding healing time and re-epithelization. There was a significantly lower pain score for patients treated with Suprathel (p=0.0002). Suprathel became transparent when applied and allowed close monitoring of wound healing. In contrast to Jelonet, Suprathel showed excellent plasticity with better attachment and adherence to wound surfaces. Throughout the healing process it detached from wounds without damaging the new epithelial surface. In addition, wound areas treated with Suprathel required less frequent dressing changes. It also demonstrated excellent ease of care. This, altogether with the significant pain reduction, presented a positive feedback by patients and healthcare professionals who both rated Suprathel as their treatment preference. Though Jelonet is more cost effective as dressing material, the study revealed an overall reduction in total treatment costs achieved with Suprathel.
  
  
  CONCLUSIONS
  Suprathel represents a solid, reliable epidermal skin substitute with impact on wound healing, patient comfort and ease of care. The material effectiveness contributes to the reduction of overall treatment costs.
authors.affiliation: Schwerbrandverletztenzentrum mit Plastischer Chirurgie, Berlin, Germany. schwarzemd@yahoo.com
authors.forename: H
authors.initials: H
authors.lastname: Schwarze
authors.forename: M
authors.initials: M
authors.lastname: Küntscher
authors.forename: C
authors.initials: C
authors.lastname: Uhlig
authors.forename: H
authors.initials: H
authors.lastname: Hierlemann
authors.forename: L
authors.initials: L
authors.lastname: Prantl
authors.forename: N
authors.initials: N
authors.lastname: Noack
authors.forename: B
authors.initials: B
authors.lastname: Hartmann
mesh_terms: D000293:Adolescent; D000328:Adult; D002056:Burns / Q000191:economics / Q000601:surgery*; D003365:Costs and Cost Analysis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D010149:Postoperative Pain / Q000209:etiology; D011446:Prospective Studies; D016038:Skin Transplantation / Q000191:economics / Q000379:methods*; D017768:Skin, Artificial / Q000191:economics; D014019:Tissue Donors; D014945:Wound Healing / Q000502:physiology*