Presence of Hb S in Uttaranchal.
Haemoglobin-S has been reported in several studies on remote populations from various parts of India eg Maharashtra, Madhya Pradesh, Andhra Pradesh, Orissa, West Bengal, Rajasthan and Malaysian Indians. Uttaranchal also has got scattered areas with people living in remote-pockets due to its geophysical nature. There has been no previous report from this state about prevalence of Hb-S. In the present study on 38 individual eight were found to have Hb-S positivity by sickling test. In one of these electrophoretic confirmation was positive with demonstration of associated Beta thalassaemia. The group was a family of muslims in village Baghori near Haldwani. Due to technical, geographical and social restrictions further study could not be done. However, this study does establish the presence of Hb-S-Beta thalassaemia in Uttaranchal State for the first time. Follow up study in the affected area and elsewhere in the state might discover more of Hb-S positivity, other haemoglobinopathies and thalassaemias.
Shukla
P K
PK
Department of Pathology, Dr. S.T.M. Forest Hospital Trust & Medical College, Haldwani.
Upadhyay
Saloni
S
Kumar
Binay
B
Thapliyal
Naveen
N
Saxena
S R
SR
Joshi
Deepak
D
D000328:Adult; D000368:Aged; D000755:Anemia, Sickle Cell / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology* / Q000473:pathology / Q000503:physiopathology; D002648:Child; D004912:Erythrocytes / Q000166:cytology; D005192:Family Health; D005260:Female; D006451:Hemoglobin, Sickle / Q000032:analysis*; D006801:Humans; D007194:India / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D017086:beta-Thalassemia / Q000453:epidemiology* / Q000473:pathology
D006451:Hemoglobin, Sickle