title: Serum adiponectin and lipid concentrations in pregnant women with polycystic ovary syndrome.
abstract: BACKGROUND
  We aimed to evaluate the serum adiponectin and lipid concentrations in normal and polycystic ovary syndrome (PCOS) women during pregnancy in order to establish whether PCOS induces abnormal lipid and adiponectin levels that could constitute potential metabolic risk factors for pregnancy complications.
  
  
  METHODS
  Women with singleton pregnancies and of similar age were included (48 pregnant PCOS and 51 normal pregnant women). During gestational weeks 10-16 and 22-28, a 2 h, 75 g oral glucose tolerance test was performed, with measurement of glucose and insulin in each sample. Adiponectin and lipid concentrations were determined in the fasting sample.
  
  
  RESULTS
  The incidence of gestational diabetes mellitus (GDM) was significantly higher in the PCOS group (12.2%) compared with the control group (2%). In PCOS patients, triglyceride (TG) concentrations and area under the curve of glucose and insulin were higher in both study periods and adiponectin concentrations were significantly lower in the second period, compared with normal women. Moreover, adiponectin concentrations were lower in women with GDM than in those with normal glucose tolerance in the two study periods.
  
  
  CONCLUSIONS
  Low adiponectin and high insulin levels are associated with GDM in pregnant PCOS patients. High TG levels seem not to be directly related to pregnancy complications in these patients.
authors.affiliation: Division of Endocrinology, Department of Internal Medicine, San Juan de Dios Hospital, School of Medicine, University of Chile, Las Palmeras11 299, Interior Quinta Normal, Casilla 33052, Correo 33, Santiago, Chile. tsir@med.uchile.cl
authors.forename: Teresa
authors.initials: T
authors.lastname: Sir-Petermann
authors.forename: Bárbara
authors.initials: B
authors.lastname: Echiburú
authors.forename: M Manuel
authors.initials: MM
authors.lastname: Maliqueo
authors.forename: Nicolas
authors.initials: N
authors.lastname: Crisosto
authors.forename: Fernando
authors.initials: F
authors.lastname: Sánchez
authors.forename: Catalina
authors.initials: C
authors.lastname: Hitschfeld
authors.forename: Michel
authors.initials: M
authors.lastname: Cárcamo
authors.forename: Pablo
authors.initials: P
authors.lastname: Amigo
authors.forename: Francisco
authors.initials: F
authors.lastname: Pérez-Bravo
mesh_terms: D052242:Adiponectin / Q000097:blood*; D019540:Area Under Curve; D016640:Diabetes, Gestational / Q000175:diagnosis*; D005260:Female; D005947:Glucose / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000378:metabolism; D008055:Lipids / Q000097:blood*; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000150:complications; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011262:Pregnancy Trimester, Second; D014280:Triglycerides / Q000378:metabolism
chemical_list: D052242:Adiponectin; D007328:Insulin; D008055:Lipids; D014280:Triglycerides; D005947:Glucose