Calcium metabolism of pregnant rats fed a vitamin D-depleted diet.
The effects of vitamin D (VD) deficiency on calcium (Ca) metabolism during pregnancy were evaluated in rats fed VD-repleted (VD-repleted rats) and VD-depleted (VD-depleted rats) diets. In the VD-depleted rats, the plasma concentrations of 1,25-dihydroxyvitamin D and Ca decreased severely, whereas the parathyroid hormone concentrations increased. The Ca contents of the feces of the VD-depleted rats were higher than those of the VD-repleted rats. The fetal Ca contents of the VD-repleted and VD-depleted rats increased continuously, but that of the VD-depleted rats was lower. These data reveal that VD deficiency during pregnancy induces severe hypocalcemia due to reduced intestinal absorption of Ca and elevated fetal demand for Ca.
Yamagishi
Norio
N
Department of Clinical Veterinary Medicine, Faculty of Agriculture, Iwate University, Morioka, Japan.
Sassa
Hiromi
H
Sato
Reeko
R
Taniguchi
Kazuyuki
K
Okura
Norimoto
N
Sato
Shigeru
S
Naito
Yoshihisa
Y
D000818:Animals; D002118:Calcium / Q000097:blood / Q000378:metabolism* / Q000652:urine; D005243:Feces / Q000737:chemistry; D005260:Female; D005269:Femur / Q000737:chemistry; D047109:Fetal Development / Q000502:physiology*; D010281:Parathyroid Hormone / Q000097:blood; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014807:Vitamin D / Q000031:analogs & derivatives / Q000097:blood; D014808:Vitamin D Deficiency / Q000378:metabolism*
D010281:Parathyroid Hormone; D014807:Vitamin D; C097949:1,25-dihydroxyvitamin D; D002118:Calcium