[Methimazole and propylthiouracil induced acute toxic hepatitis].
Hyperthyroidism is one of the most common endocrinology disorders. Treatment can be either pharmacological, surgical or using radioactive iodine. In Europe methimazole is the antithyroid drug of choice because it can be administered in a single daily dose and has a lower risk of adverse reactions. Around 5% of patients taking thionamides can present any of their side effects, which are usually mild. Liver toxicity due to thionamides is very rare, and severe due to propylthiouracil. We present a clinical case of a cholestatic jaundice and acute toxic hepatitis due to methimazole and a cross-reaction with propylthiouracil. Based on this case a review is presented.
Casallo Blanco
Sonia
S
Servicio de Medicina Interna, Hospital Nuestra Señora del Prado, Gregorio Corrochano 1, 45600 Talavera de la Reina, Toledo, Spain.
Valero
Miguel Angel
MA
Marcos Sánchez
Fernando
F
de Matías Salces
Laura
L
Blanco González
José Javier
JJ
Martín Barranco
María José
MJ
D000368:Aged; D013956:Antithyroid Agents / Q000009:adverse effects* / Q000627:therapeutic use; D019090:Case Management; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D002780:Cholestasis, Intrahepatic / Q000139:chemically induced; D005260:Female; D006111:Graves Disease / Q000188:drug therapy / Q000601:surgery; D006801:Humans; D008713:Methimazole / Q000009:adverse effects* / Q000627:therapeutic use; D013965:Thyroidectomy
D013956:Antithyroid Agents; D008713:Methimazole