title: The etiopathogenesis of Parkinson disease and suggestions for future research. Part II.
abstract: We are at a critical juncture in our knowledge of the etiology and pathogenesis of Parkinson disease (PD). It is clear that PD is not a single entity simply resulting from a dopaminergic deficit; rather it is most likely caused by a combination of genetic and environmental factors. Although there is extensive new information on the etiology and pathogenesis of PD, which may advance its treatment, new syntheses of this information are needed. The second part of this two-part, state-of-the-art review by leaders in PD research critically examines the research field to identify areas for which new knowledge and ideas might be helpful for treatment purposes. Topics reviewed in Part II are genetics, animal models, and oxidative stress.
authors.affiliation: University of Louisville School of Medicine, Louisville, Kentucky 40202, USA. i.litvan@louisville.edu
authors.forename: Irene
authors.initials: I
authors.lastname: Litvan
authors.forename: Marie-Francoise
authors.initials: MF
authors.lastname: Chesselet
authors.forename: Thomas
authors.initials: T
authors.lastname: Gasser
authors.forename: Donato A
authors.initials: DA
authors.lastname: Di Monte
authors.forename: Davis
authors.initials: D
authors.lastname: Parker
authors.forename: Theo
authors.initials: T
authors.lastname: Hagg
authors.forename: John
authors.initials: J
authors.lastname: Hardy
authors.forename: Peter
authors.initials: P
authors.lastname: Jenner
authors.forename: Richard H
authors.initials: RH
authors.lastname: Myers
authors.forename: Donald
authors.initials: D
authors.lastname: Price
authors.forename: Mark
authors.initials: M
authors.lastname: Hallett
authors.forename: William J
authors.initials: WJ
authors.lastname: Langston
authors.forename: Anthony E
authors.initials: AE
authors.lastname: Lang
authors.forename: Glenda
authors.initials: G
authors.lastname: Halliday
authors.forename: Walter
authors.initials: W
authors.lastname: Rocca
authors.forename: Charles
authors.initials: C
authors.lastname: Duyckaerts
authors.forename: Dennis W
authors.initials: DW
authors.lastname: Dickson
authors.forename: Yoav
authors.initials: Y
authors.lastname: Ben-Shlomo
authors.forename: Christopher G
authors.initials: CG
authors.lastname: Goetz
authors.forename: Eldad
authors.initials: E
authors.lastname: Melamed
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005544:Forecasting; D006801:Humans; D018384:Oxidative Stress / Q000502:physiology; D010300:Parkinson Disease / Q000209:etiology* / Q000235:genetics* / Q000628:therapy; D012106:Research / Q000639:trends*