Oligosaccharide synthesis in microreactors.
Described is the combination of microreactors and fluorous phase chemistry to assemble oligosaccharides. The synthesis of a beta-(1-->6) linked D-glucopyranoside homotetramer serves to illustrate this approach. Glycosylations employing a Fmoc-protected glucosyl phosphate building block were performed in a silicon-based micro-structured device to optimize reaction conditions and for reaction scale-up. A perfluorinated linker at the reducing end of the oligosaccharides allowed for purification by fluorous solid-phase extraction (FSPE) and further functionalization.
Carrel
Frédéric R
FR
Laboratory of Organic Chemistry, Swiss Federal Institute of Technology ETH Zürich, Zürich, Switzerland.
Geyer
Karolin
K
Codée
Jeroen D C
JD
Seeberger
Peter H
PH