title: Aligned arrays of biodegradable poly(epsilon-caprolactone) nanowires and nanofibers by template synthesis.
abstract: We demonstrate that the technically simple, low-cost, and rapid method of template synthesis can be used to create arrays of nanowires and nanofibers from the biocompatible, biodegradable polymer poly(epsilon-caprolactone) (PCL). PCL substrates introduced into a standard laboratory oven at temperatures as low as 65 degrees C are able to form nanostructures. Nanostructure morphology can be controlled, and complex patterning can be achieved. Solvent-free and low-temperature fabrications also allow for the encapsulation of therapeutics for sustained release.
authors.affiliation: Department or Physiology, University of California, San Francisco, 1700 4th Street, San Francisco, California 94143, USA.
authors.forename: Sarah L
authors.initials: SL
authors.lastname: Tao
authors.forename: Tejal A
authors.initials: TA
authors.lastname: Desai
mesh_terms: D020341:Absorbable Implants; D001672:Biocompatible Materials / Q000737:chemistry*; D003460:Crystallization / Q000379:methods*; D004337:Drug Carriers / Q000737:chemistry*; D046911:Macromolecular Substances / Q000737:chemistry; D008422:Materials Testing; D008968:Molecular Conformation; D036103:Nanotechnology / Q000379:methods*; D043942:Nanotubes / Q000737:chemistry* / Q000648:ultrastructure*; D010316:Particle Size; D011091:Polyesters / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D001672:Biocompatible Materials; D004337:Drug Carriers; D046911:Macromolecular Substances; D011091:Polyesters; C016240:polycaprolactone