title: An efficient Bayesian model selection approach for interacting quantitative trait loci models with many effects.
abstract: We extend our Bayesian model selection framework for mapping epistatic QTL in experimental crosses to include environmental effects and gene-environment interactions. We propose a new, fast Markov chain Monte Carlo algorithm to explore the posterior distribution of unknowns. In addition, we take advantage of any prior knowledge about genetic architecture to increase posterior probability on more probable models. These enhancements have significant computational advantages in models with many effects. We illustrate the proposed method by detecting new epistatic and gene-sex interactions for obesity-related traits in two real data sets of mice. Our method has been implemented in the freely available package R/qtlbim (http://www.qtlbim.org) to facilitate the general usage of the Bayesian methodology for genomewide interacting QTL analysis.
authors.affiliation: Department of Biostatistics, Section on Statistical Genetics, University of Alabama, Birmingham, Alabama 35294-0022, USA. nyi@ms.soph.uab.eduUT
authors.forename: Nengjun
authors.initials: N
authors.lastname: Yi
authors.forename: Daniel
authors.initials: D
authors.lastname: Shriner
authors.forename: Samprit
authors.initials: S
authors.lastname: Banerjee
authors.forename: Tapan
authors.initials: T
authors.lastname: Mehta
authors.forename: Daniel
authors.initials: D
authors.lastname: Pomp
authors.forename: Brian S
authors.initials: BS
authors.lastname: Yandell
mesh_terms: D000465:Algorithms; D000818:Animals; D001499:Bayes Theorem; D004843:Epistasis, Genetic; D008390:Markov Chains; D051379:Mice; D008957:Models, Genetic; D009010:Monte Carlo Method; D009765:Obesity / Q000235:genetics; D040641:Quantitative Trait Loci