title: Bioactive compounds from Bauhinia purpurea possessing antimalarial, antimycobacterial, antifungal, anti-inflammatory, and cytotoxic activities.
abstract: Eleven new secondary metabolites (1-11), together with two known flavanones (12 and 13) and five known bibenzyls (14-18), were isolated from the root extract of Bauhinia purpurea. New compounds include eight dihydrodibenzoxepins (1-8), a dihydrobenzofuran (9), a novel spirochromane-2,1'-hexenedione (10), and a new bibenzyl (11). Antimycobacterial, antimalarial, antifungal, cytotoxic, and anti-inflammatory activities of the isolated compounds are reported, and biosynthetic pathways of these compounds are also discussed.
authors.affiliation: Department of Chemistry, Faculty of Science, Chiang Mai University, Chiang Mai, Thailand.
authors.forename: Surat
authors.initials: S
authors.lastname: Boonphong
authors.forename: Pakawan
authors.initials: P
authors.lastname: Puangsombat
authors.forename: Apiwat
authors.initials: A
authors.lastname: Baramee
authors.forename: Chulabhorn
authors.initials: C
authors.lastname: Mahidol
authors.forename: Somsak
authors.initials: S
authors.lastname: Ruchirawat
authors.forename: Prasat
authors.initials: P
authors.lastname: Kittakoop
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D036481:Bauhinia / Q000737:chemistry*; D001584:Benzoxepins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001632:Bibenzyls / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D044950:Flavanones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D013141:Spiro Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D013785:Thailand
chemical_list: D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D000935:Antifungal Agents; D000962:Antimalarials; D001584:Benzoxepins; D001632:Bibenzyls; D044950:Flavanones; D013141:Spiro Compounds; C521024:bauhispirorin A