[Function and role of the sarcoplasmic reticulum in heart disease].
The sarcoplasmic reticulum (SR) constitutes the main intracellular calcium store in striated muscle and plays an important role in the regulation of excitation-contraction-coupling (ECC) and of intracellular calcium concentrations during contraction and relaxation. The regulation of ECC occurs due to the interaction among the main proteins of the SR that are the calcium release channel or ryanodine receptor, the Ca2+-ATPase, phospholamban and calsequestrin. Due to the importance of ECC in the physiopathology of a number of cardiac diseases, the role of the SR and its components has been widely investigated in some pathologies, specifically cardiac hypertrophy, heart failure, and hereditary arrhythmias. Therefore, the SR proteins constitute an area of research of great interest for the development of new genetic and pharmacologic therapies; from this derives the importance of understanding the function of the SR. This review analyzes the expression, structure, and function of the main SR proteins, their role on myocardial contraction and relaxation and in the changes that occur in cardiac pathologies.
Reyes-Juárez
José Luis
JL
Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, UNAM, México D.F.
Zarain-Herzberg
Angel
A
D001145:Arrhythmias, Cardiac / Q000378:metabolism / Q000503:physiopathology; D002118:Calcium / Q000378:metabolism; D015220:Calcium Channels / Q000378:metabolism; D002135:Calcium-Binding Proteins / Q000378:metabolism; D000252:Calcium-Transporting ATPases / Q000378:metabolism; D002155:Calsequestrin / Q000378:metabolism; D006332:Cardiomegaly / Q000378:metabolism / Q000503:physiopathology; D006331:Heart Diseases / Q000378:metabolism / Q000503:physiopathology*; D006333:Heart Failure / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D009200:Myocardial Contraction / Q000502:physiology*; D009206:Myocardium / Q000378:metabolism; D012106:Research; D012519:Sarcoplasmic Reticulum / Q000378:metabolism / Q000502:physiology*; D053498:Sarcoplasmic Reticulum Calcium-Transporting ATPases / Q000378:metabolism; D000099211:Phospholamban
D002118:Calcium; D015220:Calcium Channels; D002135:Calcium-Binding Proteins; D000252:Calcium-Transporting ATPases; D002155:Calsequestrin; D053498:Sarcoplasmic Reticulum Calcium-Transporting ATPases; D000099211:Phospholamban