title: Effects of mutant Drosophila K+ channel subunits on habituation of the olfactory jump response.
abstract: The olfactory-jump response assay was used to analyze habituation in Drosophila mutants of potassium (K(+)) channel subunits. As with physiological assays of the giant fiber-mediated escape reflex, mutations at loci that encode K(+) channel subunits have distinct effects on habituating the olfactory-jump response. The data for slowpoke and ether à go-go indicate similar effects on habituation of the olfactory-jump response and the giant fiber-mediated escape. Habituation in the olfactory jump assay in Hyperkinetic and Shaker mutants was drastically different from the degree of defect in the giant fiber-mediated escape reflex, indicating differential control mechanisms underlying the two forms of non-associative conditioning.
authors.affiliation: Department of Biological Sciences, University of Iowa, Iowa City, IA 52242, USA.
authors.forename: M A
authors.initials: MA
authors.lastname: Joiner
authors.forename: Z
authors.initials: Z
authors.lastname: Asztalos
authors.forename: C J
authors.initials: CJ
authors.lastname: Jones
authors.forename: T
authors.initials: T
authors.lastname: Tully
authors.forename: C-F
authors.initials: CF
authors.lastname: Wu
mesh_terms: D000818:Animals; D003214:Conditioning, Classical; D029721:Drosophila Proteins / Q000235:genetics*; D004331:Drosophila melanogaster / Q000235:genetics*; D017344:Genes, Insect; D006185:Habituation, Psychophysiologic; D009154:Mutation; D009473:Neuronal Plasticity; D015221:Potassium Channels / Q000235:genetics*; D012903:Smell
chemical_list: D029721:Drosophila Proteins; D015221:Potassium Channels