Serum adiponectin and lipid concentrations in pregnant women with polycystic ovary syndrome.
BACKGROUND
We aimed to evaluate the serum adiponectin and lipid concentrations in normal and polycystic ovary syndrome (PCOS) women during pregnancy in order to establish whether PCOS induces abnormal lipid and adiponectin levels that could constitute potential metabolic risk factors for pregnancy complications.


METHODS
Women with singleton pregnancies and of similar age were included (48 pregnant PCOS and 51 normal pregnant women). During gestational weeks 10-16 and 22-28, a 2 h, 75 g oral glucose tolerance test was performed, with measurement of glucose and insulin in each sample. Adiponectin and lipid concentrations were determined in the fasting sample.


RESULTS
The incidence of gestational diabetes mellitus (GDM) was significantly higher in the PCOS group (12.2%) compared with the control group (2%). In PCOS patients, triglyceride (TG) concentrations and area under the curve of glucose and insulin were higher in both study periods and adiponectin concentrations were significantly lower in the second period, compared with normal women. Moreover, adiponectin concentrations were lower in women with GDM than in those with normal glucose tolerance in the two study periods.


CONCLUSIONS
Low adiponectin and high insulin levels are associated with GDM in pregnant PCOS patients. High TG levels seem not to be directly related to pregnancy complications in these patients.
Sir-Petermann
Teresa
T
Division of Endocrinology, Department of Internal Medicine, San Juan de Dios Hospital, School of Medicine, University of Chile, Las Palmeras11 299, Interior Quinta Normal, Casilla 33052, Correo 33, Santiago, Chile. tsir@med.uchile.cl
Echiburú
Bárbara
B
Maliqueo
M Manuel
MM
Crisosto
Nicolas
N
Sánchez
Fernando
F
Hitschfeld
Catalina
C
Cárcamo
Michel
M
Amigo
Pablo
P
Pérez-Bravo
Francisco
F
D052242:Adiponectin / Q000097:blood*; D019540:Area Under Curve; D016640:Diabetes, Gestational / Q000175:diagnosis*; D005260:Female; D005947:Glucose / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000378:metabolism; D008055:Lipids / Q000097:blood*; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000150:complications; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011262:Pregnancy Trimester, Second; D014280:Triglycerides / Q000378:metabolism
D052242:Adiponectin; D007328:Insulin; D008055:Lipids; D014280:Triglycerides; D005947:Glucose