title: A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants.
abstract: Identifying the genetic variants that increase the risk of type 2 diabetes (T2D) in humans has been a formidable challenge. Adopting a genome-wide association strategy, we genotyped 1161 Finnish T2D cases and 1174 Finnish normal glucose-tolerant (NGT) controls with >315,000 single-nucleotide polymorphisms (SNPs) and imputed genotypes for an additional >2 million autosomal SNPs. We carried out association analysis with these SNPs to identify genetic variants that predispose to T2D, compared our T2D association results with the results of two similar studies, and genotyped 80 SNPs in an additional 1215 Finnish T2D cases and 1258 Finnish NGT controls. We identify T2D-associated variants in an intergenic region of chromosome 11p12, contribute to the identification of T2D-associated variants near the genes IGF2BP2 and CDKAL1 and the region of CDKN2A and CDKN2B, and confirm that variants near TCF7L2, SLC30A8, HHEX, FTO, PPARG, and KCNJ11 are associated with T2D risk. This brings the number of T2D loci now confidently identified to at least 10.
authors.affiliation: Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA.
authors.forename: Laura J
authors.initials: LJ
authors.lastname: Scott
authors.forename: Karen L
authors.initials: KL
authors.lastname: Mohlke
authors.forename: Lori L
authors.initials: LL
authors.lastname: Bonnycastle
authors.forename: Cristen J
authors.initials: CJ
authors.lastname: Willer
authors.forename: Yun
authors.initials: Y
authors.lastname: Li
authors.forename: William L
authors.initials: WL
authors.lastname: Duren
authors.forename: Michael R
authors.initials: MR
authors.lastname: Erdos
authors.forename: Heather M
authors.initials: HM
authors.lastname: Stringham
authors.forename: Peter S
authors.initials: PS
authors.lastname: Chines
authors.forename: Anne U
authors.initials: AU
authors.lastname: Jackson
authors.forename: Ludmila
authors.initials: L
authors.lastname: Prokunina-Olsson
authors.forename: Chia-Jen
authors.initials: CJ
authors.lastname: Ding
authors.forename: Amy J
authors.initials: AJ
authors.lastname: Swift
authors.forename: Narisu
authors.initials: N
authors.lastname: Narisu
authors.forename: Tianle
authors.initials: T
authors.lastname: Hu
authors.forename: Randall
authors.initials: R
authors.lastname: Pruim
authors.forename: Rui
authors.initials: R
authors.lastname: Xiao
authors.forename: Xiao-Yi
authors.initials: XY
authors.lastname: Li
authors.forename: Karen N
authors.initials: KN
authors.lastname: Conneely
authors.forename: Nancy L
authors.initials: NL
authors.lastname: Riebow
authors.forename: Andrew G
authors.initials: AG
authors.lastname: Sprau
authors.forename: Maurine
authors.initials: M
authors.lastname: Tong
authors.forename: Peggy P
authors.initials: PP
authors.lastname: White
authors.forename: Kurt N
authors.initials: KN
authors.lastname: Hetrick
authors.forename: Michael W
authors.initials: MW
authors.lastname: Barnhart
authors.forename: Craig W
authors.initials: CW
authors.lastname: Bark
authors.forename: Janet L
authors.initials: JL
authors.lastname: Goldstein
authors.forename: Lee
authors.initials: L
authors.lastname: Watkins
authors.forename: Fang
authors.initials: F
authors.lastname: Xiang
authors.forename: Jouko
authors.initials: J
authors.lastname: Saramies
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Buchanan
authors.forename: Richard M
authors.initials: RM
authors.lastname: Watanabe
authors.forename: Timo T
authors.initials: TT
authors.lastname: Valle
authors.forename: Leena
authors.initials: L
authors.lastname: Kinnunen
authors.forename: Gonçalo R
authors.initials: GR
authors.lastname: Abecasis
authors.forename: Elizabeth W
authors.initials: EW
authors.lastname: Pugh
authors.forename: Kimberly F
authors.initials: KF
authors.lastname: Doheny
authors.forename: Richard N
authors.initials: RN
authors.lastname: Bergman
authors.forename: Jaakko
authors.initials: J
authors.lastname: Tuomilehto
authors.forename: Francis S
authors.initials: FS
authors.lastname: Collins
authors.forename: Michael
authors.initials: M
authors.lastname: Boehnke
mesh_terms: D016022:Case-Control Studies; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics; D021901:DNA, Intergenic; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D005260:Female; D005387:Finland; D019942:Genes, p16; D020022:Genetic Predisposition to Disease; D015894:Genome, Human; D005838:Genotype; D006801:Humans; D018969:Insulin-Like Growth Factor Binding Proteins / Q000235:genetics; D007438:Introns; D016015:Logistic Models; D008297:Male; D015201:Meta-Analysis as Topic; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide
chemical_list: D021901:DNA, Intergenic; D018969:Insulin-Like Growth Factor Binding Proteins