title: Intestinal endometriosis complicated by ileal perforation after initiation of gonadotropin-releasing hormone agonist therapy.
abstract: OBJECTIVE
  To report a rare complication of GnRH agonist therapy for intestinal endometriosis.
  
  
  METHODS
  Case report.
  
  
  METHODS
  University hospital.
  
  
  METHODS
  A 45-year-old nulliparous Japanese woman with catamenial digestive symptoms.
  
  
  METHODS
  GnRH agonist therapy.
  
  
  METHODS
  Acute abdomenal crisis with free air in the abdominal X-ray.
  
  
  RESULTS
  An emergency laparotomy showed both an ileal constriction and perforation. An ileocecal enterectomy with an end-to-end anastomosis was performed. A pathological examination of the ileum revealed ileal endometriosis.
  
  
  CONCLUSIONS
  Flare-up of intestinal endometriosis induced by GnRH agonist has the potential to lead to intestinal perforation. Careful diagnosis and treatment are necessary for cyclic and periodic gastrointestinal manifestation.
authors.affiliation: Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan.
authors.forename: Sayaka
authors.initials: S
authors.lastname: Saito
authors.forename: Takashi
authors.initials: T
authors.lastname: Murakami
authors.forename: Kichiya
authors.initials: K
authors.lastname: Suzuki
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Terada
authors.forename: Kouhei
authors.initials: K
authors.lastname: Fukushima
authors.forename: Takuya
authors.initials: T
authors.lastname: Moriya
mesh_terms: D000006:Abdomen, Acute / Q000139:chemically induced*; D004715:Endometriosis / Q000139:chemically induced / Q000150:complications*; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists*; D006801:Humans; D007077:Ileal Diseases / Q000209:etiology*; D007416:Intestinal Perforation / Q000209:etiology*; D016729:Leuprolide / Q000009:adverse effects*; D008875:Middle Aged
chemical_list: D007987:Gonadotropin-Releasing Hormone; D016729:Leuprolide