title: Central airway obstruction caused by a peripheral hamartoma.
abstract: We report the first case of a hamartoma, arising from peripheral lung tissue, which extended proximally over several decades to occlude the large airways. The patient's symptoms were originally attributed to asthma and the correct diagnosis was only made when she developed life-threatening airway obstruction. The endobronchial component of the hamartoma was debulked with urgent laser therapy, while the peripheral base of the tumour was resected by elective right middle lobectomy.
authors.affiliation: Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, United Kingdom. goodmana@well.ox.ac.uk
authors.forename: Anna
authors.initials: A
authors.lastname: Goodman
authors.forename: Mary
authors.initials: M
authors.lastname: Falzon
authors.forename: Colin
authors.initials: C
authors.lastname: Gelder
authors.forename: Jeremy
authors.initials: J
authors.lastname: George
mesh_terms: D000402:Airway Obstruction / Q000175:diagnosis* / Q000209:etiology; D005260:Female; D006222:Hamartoma / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D008875:Middle Aged