title: Angiogenesis and the tumour hypoxia response in prostate cancer: a review.
abstract: The formation of new blood vessels, angiogenesis, is a highly-regulated active process that is critical for the development of the normal and malignant prostate. The vascular endothelial growth factor (VEGF) system assumes a critical role in the angiogenic process. Angiogenesis is a prerequisite for the expansion of solid tumours beyond 1-3 mm3 and is stimulated in response to a hypoxic environment. This review discusses the process of angiogenesis and the key angiogenic mediator, VEGF, and their role in tumour progression and metastasis. A better understanding of the mechanisms behind angiogenesis will ultimately lead to the development of new anti-angiogenic agents in the management of prostate cancer.
authors.affiliation: University of Surrey, UK. p.s@doctors.org.uk
authors.forename: P
authors.initials: P
authors.lastname: Sooriakumaran
authors.forename: R
authors.initials: R
authors.lastname: Kaba