Carboxymethylated (1 --> 3)-beta-D-glucan protects liposomes against ultraviolet light-induced lipid peroxidation.
In this study we have analyzed antioxidant capabilities of the carboxymethylated (1 --> 3)-beta-D-glucan (M(w) = 5.88 x 10(5)) against lipid peroxidation induced by ultraviolet (UV) radiation--UVA (320-400 nm), which is known to produce mainly singlet oxygen, (1)O(2) . Lipid peroxidation was monitored by measuring the absorption spectra of the conjugated dienes and quantified by Klein oxidation index. The results imply that the (1 --> 3)-beta-D-glucan derivative studied is an antioxidant with the scavenging ability lying between alpha-tocopherol and hyaluronic acid. Thus, glucan as a potential safe and effective dietary supplement may be used for a prolonged time for a systemic photoprotection of humans.
Schronerová
K
K
Department of Biophysics, Comenius University, Bratislava, Slovakia.
Babincová
M
M
Machová
E
E
Kogan
G
G
D000975:Antioxidants / Q000494:pharmacology*; D019587:Dietary Supplements; D005936:Glucans / Q000494:pharmacology*; D017665:Hydroxyl Radical / Q000737:chemistry; D015227:Lipid Peroxidation / Q000187:drug effects / Q000528:radiation effects*; D008081:Liposomes / Q000737:chemistry*; D010545:Peroxides / Q000737:chemistry; D026082:Singlet Oxygen / Q000737:chemistry; D014466:Ultraviolet Rays
D000975:Antioxidants; D005936:Glucans; D008081:Liposomes; D010545:Peroxides; D026082:Singlet Oxygen; C049375:perhydroxyl radical; D017665:Hydroxyl Radical