Anticonvulsant hypersensitivity syndrome associated with Epstein-Barr virus reactivation.
We describe a 59-year-old female with severe anticonvulsant hypersensitivity syndrome (AHS) associated with Epstein- Barr virus (EBV) infection. The causative drug was speculated to be carbamazepine. Recurrent EBV infection was demonstrated by the presence of anti-EBV early antigen IgM antibodies and anti-EBV nuclear antigen IgG antibodies. To our knowledge, only one case of drug hypersensitivity syndrome (DHS) associated with EBV has been reported in the English- language literature. Our case is the second report of EBV-associated DHS, which suggests that EBV infection may contribute to the pathogenesis of AHS in a few patients.
Chang
Jae Yong
JY
Department of Dermatology, Yonsei University College of Medicine, Yongdong Severance Hospital, 146-92 Dogok-Dong, Kangnam-Gu, Seoul, Korea. kimsc@yumc.yonsei.ac.kr
Kim
Soo-Chan
SC
D000927:Anticonvulsants / Q000009:adverse effects*; D004342:Drug Hypersensitivity; D020031:Epstein-Barr Virus Infections / Q000503:physiopathology*; D004890:Erythema / Q000209:etiology / Q000821:virology; D005260:Female; D004854:Herpesvirus 4, Human / Q000187:drug effects / Q000472:pathogenicity; D006801:Humans; D008875:Middle Aged; D014617:Vacuoles / Q000473:pathology; D014775:Virus Activation / Q000502:physiology*
D000927:Anticonvulsants