The role of Granzyme B in atheromatous diseases.
The mechanism and role of apoptotic cell death in the pathogenesis of atheromatous diseases is an area of intense research. Atherosclerosis is an inflammatory disease and as such, immune-mediated cell killing plays an important role. Recent studies have suggested that Granzyme B and perforin play an important role in atherogenesis. The current manuscript reviews our current understanding pertaining to the role of Granzyme B in cardiac allograft vasculopathy and atherosclerosis.
Chamberlain
Ciara M
CM
James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St. Paul's Hospital, University of British Columbia, 1081 Burrard St, Vancouver, BC V6Z 1Y6, Canada.
Granville
David J
DJ
D000818:Animals; D017209:Apoptosis; D050197:Atherosclerosis / Q000201:enzymology* / Q000473:pathology; D003324:Coronary Artery Disease / Q000201:enzymology* / Q000209:etiology / Q000473:pathology; D005109:Extracellular Matrix / Q000378:metabolism; D053804:Granzymes / Q000378:metabolism*; D016027:Heart Transplantation / Q000009:adverse effects*; D006801:Humans; D008562:Membrane Glycoproteins / Q000378:metabolism*; D054353:Perforin; D052899:Pore Forming Cytotoxic Proteins / Q000378:metabolism*; D015398:Signal Transduction
D008562:Membrane Glycoproteins; D052899:Pore Forming Cytotoxic Proteins; D054353:Perforin; D053804:Granzymes