Significance of blood analysis in hemophiliacs co-infected with human immunodeficiency virus and hepatitis viruses.
OBJECTIVE
To study the effect of hepatitis virus infection on cirrhosis and liver function markers in HIV-infected hemophiliacs.


METHODS
We have analyzed the immunological, liver function and cirrhosis markers in a cohort of hemophiliacs co-infected with human immunodeficiency virus (HIV) and hepatitis viruses.


RESULTS
There was no difference in immunological markers among co-infected patients and patients infected with HIV only and those co-infected with one or more hepatitis virus. Although liver function and cirrhosis markers remained within a normal range, there was a worsening trend in all patients co-infected with hepatitis virus C (HCV), which was further exacerbated in the presence of additional infection with hepatitis virus B (HBV).


CONCLUSIONS
Co-infection with HIV, HBV and HCV leads to worsening of hyaluronic acid and liver function markers. Increases in serum hyaluronic acid may be suggestive of a predisposition to liver diseases.
Shen
Fang
F
Shanghai Medical College and Shanghai Public Health Center, Fudan University, Shanghai 201508, China.
Huang
Qin
Q
Sun
Hong-Qing
HQ
Ghildyal
Reena
R
D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D016516:CD4-CD8 Ratio; D002681:China; D015331:Cohort Studies; D018450:Disease Progression; D015658:HIV Infections / Q000097:blood* / Q000150:complications; D006467:Hemophilia A / Q000097:blood* / Q000150:complications; D006509:Hepatitis B / Q000097:blood* / Q000150:complications; D006526:Hepatitis C / Q000097:blood* / Q000150:complications; D006801:Humans; D006820:Hyaluronic Acid / Q000097:blood; D008099:Liver / Q000378:metabolism / Q000473:pathology / Q000821:virology; D008103:Liver Cirrhosis / Q000097:blood / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D019562:Viral Load
D015415:Biomarkers; D006820:Hyaluronic Acid