Triplex DNA and human disease.
Mutagenesis is the fulcrum for the balance between the fidelity of the genetic code and evolution. While there are an enormous number of extrinsic factors driving mutagenesis, alternative DNA secondary structure is one of the intrinsic components that impacts regional genomic stability. Some alternative DNA structures are associated with human diseases, and this review focuses on disease-associated polypurine polypyrimidine mirror repeat sequences.
Bissler
John J
JJ
Department of Pediatrics, Division of Nephrology, Cincinnati Children's Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, OH 45229-3039, USA. john.bissler@cchmc.org
D004247:DNA / Q000737:chemistry / Q000502:physiology*; D004194:Disease; D006801:Humans; D009690:Nucleic Acid Conformation; D012091:Repetitive Sequences, Nucleic Acid
C051802:triplex DNA; D004247:DNA