title: Menopause, estrogens, progestins, or their combination on body weight and anthropometric measures.
abstract: OBJECTIVE
  To evaluate modification in body weight and anthropometric indexes in women at the time of menopause.
  
  
  METHODS
  Prospective longitudinal study.
  
  
  METHODS
  Menopause Center at the University Hospital of Modena.
  
  
  METHODS
  Women in perimenopause (n = 87), ovariectomized (n = 60), and in postmenopause (n = 182) without and with treatment.
  
  
  METHODS
  Data were retrieved from the electronic database of the Menopause Center.
  
  
  METHODS
  Modification of weight, body mass index (BMI), waist, hip, and waist-to-hip ratio in 12 months.
  
  
  RESULTS
  Body weight increased in perimenopausal (0.6 +/- 0.1 kg) women, did not vary in postmenopausal (0.2 +/- 0.1 kg) women, and decreased in ovariectomized (-0.5 +/- 0.3 kg) women. Waist increased significantly in perimenopausal (2.3 +/- 0.4 cm) and in postmenopausal (2.0 +/- 0.4 cm) women. In comparison to no treatment, progestin administration (n = 29) decreased body weight (-0.2 +/- 0.5 kg) and hip (-1.1 +/- 0.9 cm) in perimenopausal women, estrogen (E) administration (n = 38) increased body weight (0.8 +/- 0.3 kg) in ovariectomized women, whereas E plus progestin administration (n = 89) did not induce any modification in postmenopausal women.
  
  
  CONCLUSIONS
  Present preliminary data indicate that body weight increases in perimenopausal women, decreases in ovariectomized women, and does not increase significantly in naturally postmenopausal women. Estrogens and progestins influence body weight differently, increasing and decreasing it, respectively.
authors.affiliation: Department of Obstetrics Gynecology and Pediatrics, University of Modena, Modena, Italy. cagnacci@unimore.it
authors.forename: Angelo
authors.initials: A
authors.lastname: Cagnacci
authors.forename: Renata
authors.initials: R
authors.lastname: Zanin
authors.forename: Marianna
authors.initials: M
authors.lastname: Cannoletta
authors.forename: Matteo
authors.initials: M
authors.lastname: Generali
authors.forename: Simona
authors.initials: S
authors.lastname: Caretto
authors.forename: Annibale
authors.initials: A
authors.lastname: Volpe
mesh_terms: D000886:Anthropometry; D001835:Body Weight / Q000187:drug effects* / Q000502:physiology; D001837:Body Weights and Measures; D016208:Databases, Factual; D004359:Drug Therapy, Combination; D015914:Estrogen Replacement Therapy; D004967:Estrogens / Q000008:administration & dosage*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007044:Hysterectomy; D008593:Menopause / Q000187:drug effects / Q000502:physiology*; D008594:Menopause, Premature / Q000187:drug effects; D008875:Middle Aged; D010052:Ovariectomy; D047648:Perimenopause / Q000502:physiology; D011372:Progestins / Q000008:administration & dosage*; D012189:Retrospective Studies
chemical_list: D004967:Estrogens; D011372:Progestins