title: Aggressive behavior of low-grade Ta papillary urothelial bladder neoplasm in a 17-year-old patient.
abstract: Bladder tumors rarely occur in the first two decades of life, and, in contrast to the cases in adults, 97% of transitional cell carcinomas of the bladder in childhood are low grade, superficial, and of good prognosis, with a progression rate of only 2% to 4%. This report presents a case of low-grade bladder cancer in a 17-year-old patient which behaved quite aggressively. The most striking features of this case included the histopathologic findings and rapid disease progression, despite treatment with agents known for their efficacy against tumors of epithelial and mesenchymal origin.
authors.affiliation: Department of Urology, Martha Maria Medical Center, Academic Hospital of Erlangen University, Nürnberg, Germany. labanaris@web.de <labanaris@web.de>
authors.forename: Apostolos P
authors.initials: AP
authors.lastname: Labanaris
authors.forename: Panagiotis G
authors.initials: PG
authors.lastname: Labanaris
authors.forename: Giorgos
authors.initials: G
authors.lastname: Gitsos
authors.forename: Reinhard
authors.initials: R
authors.lastname: Kühn
authors.forename: Ghünter E
authors.initials: GE
authors.lastname: Schott
authors.forename: Vahudin
authors.initials: V
authors.lastname: Zugor
mesh_terms: D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001707:Biopsy, Needle; D002291:Carcinoma, Papillary / Q000473:pathology* / Q000628:therapy*; D003131:Combined Modality Therapy; D015653:Cystectomy / Q000379:methods; D003558:Cystoscopy; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D008197:Lymph Node Excision / Q000379:methods; D008297:Male; D009361:Neoplasm Invasiveness / Q000473:pathology; D009364:Neoplasm Recurrence, Local / Q000473:pathology* / Q000601:surgery; D011468:Prostatectomy / Q000379:methods; D018714:Radiotherapy, Adjuvant; D018570:Risk Assessment; D016896:Treatment Outcome; D001749:Urinary Bladder Neoplasms / Q000473:pathology* / Q000628:therapy*