[Effect of volatile inhalational anesthetics on cerebral blood volume and oxygen status in children].
The investigation evaluated the effect of various volatile anesthetics on cerebral blood volume and oxygen status in sick children at the stage of anesthesia induction. Ninety-two children were distributed into 3 groups: Groups 1 (n = 36) and 2 (n = 24) underwent stepwise induction with halothane and enflurane, respectively. Group 3 (n = 32) had vital capacity rapid inhalation induction with sevoflurane. Cerebral oximetry (NIRS method) was used to measure the content of hydroxyhemoglobin, deoxyhemoglobin, the total level of hemoglobin and to assess regional cerebral tissue saturation (rSO2). Halothane was ascertained to increase cerebral blood volume by 20.5% whereas enflurane and sevoflurane increased it only by 8.8 and 9.0%, respectively. In all cases, the value of rSO2 remained comparatively high, by exceeding the baseline level by 3-5%.
Tsypin
L E
LE
Prokop'ev
G G
GG
Lazarev
V V
VV
Shchukin
V V
VV
Popova
T G
TG
Kochkin
V S
VS
Lin'kova
T V
TV
Chusov
K P
KP
D000293:Adolescent; D018685:Anesthetics, Inhalation / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D001810:Blood Volume / Q000187:drug effects*; D001921:Brain / Q000098:blood supply / Q000187:drug effects; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D002648:Child; D002675:Child, Preschool; D004737:Enflurane / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D006221:Halothane / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007700:Kinetics; D008738:Methyl Ethers / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D010092:Oximetry; D010100:Oxygen / Q000097:blood*; D000077149:Sevoflurane; D014835:Volatilization
D018685:Anesthetics, Inhalation; D006454:Hemoglobins; D008738:Methyl Ethers; D000077149:Sevoflurane; D004737:Enflurane; D010100:Oxygen; D006221:Halothane