title: The effect of mode of delivery on placental chorionic plate vascular reactivity.
abstract: OBJECTIVE
  To determine whether delivery mode influences placental chorionic plate arterial and venous vascular reactivity.
  
  
  METHODS
  Normal term placentas were obtained after vaginal delivery or cesarean section. Chorionic plate arterial and venous function was assessed by wire myography.
  
  
  RESULTS
  Sodium nitroprusside-induced arterial relaxation increased post cesarean section at 20% oxygen. Decreased U46619-induced venous contraction was observed in vaginal deliveries at 7% oxygen. Sodium nitroprusside-induced relaxation increased in vaginal delivery at 20% oxygen.
  
  
  CONCLUSIONS
  Delivery mode does not alter chorionic plate arterial vascular reactivity under physiological conditions, however venous reactivity was modified, a factor for consideration when interpreting functional experimental data.
authors.affiliation: Division of Human Development, The University of Manchester, Manchester, UK. tracey.mills@manchester.ac.uk
authors.forename: Tracey A
authors.initials: TA
authors.lastname: Mills
authors.forename: Philip N
authors.initials: PN
authors.lastname: Baker
authors.forename: Mark
authors.initials: M
authors.lastname: Wareing
mesh_terms: D019796:15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid / Q000494:pharmacology; D000328:Adult; D000704:Analysis of Variance; D001158:Arteries / Q000187:drug effects / Q000502:physiology; D002823:Chorion / Q000098:blood supply*; D036861:Delivery, Obstetric; D004305:Dose-Response Relationship, Drug; D004730:Endothelium, Vascular / Q000187:drug effects; D005260:Female; D006801:Humans; D009213:Myography; D009599:Nitroprusside / Q000494:pharmacology; D010100:Oxygen / Q000097:blood; D010920:Placenta / Q000098:blood supply*; D021041:Placental Circulation / Q000187:drug effects; D011247:Pregnancy; D012016:Reference Values; D014661:Vasoconstriction / Q000187:drug effects; D014662:Vasoconstrictor Agents / Q000494:pharmacology; D014664:Vasodilation / Q000187:drug effects; D014665:Vasodilator Agents / Q000494:pharmacology; D014680:Veins / Q000187:drug effects / Q000502:physiology
chemical_list: D014662:Vasoconstrictor Agents; D014665:Vasodilator Agents; D009599:Nitroprusside; D019796:15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; D010100:Oxygen