[Current trends in fluorine research].
OBJECTIVE
Current topics in fluorine research are presented with emphasis on findings by researchers in Szczecin and Poland, as well as in the world. Reports are cited on the distribution of fluorine compounds in the environment, routes of penetration into living organisms, and analytical methods for the quantitative determinations of fluorine content in air, water, soil, and foods. Important contributions have been made by Polish researchers on the role and patterns of fluorides in body fluids, soft and hard tissues, which remain in direct relationship to accumulation and elimination of fluorine. So far, comprehensive studies on mutagenic effects of fluorine and its potential role in bone neoplasms, Down syndrome, and other genetic disorders have not been carried out in Poland. Worthy of mention are reports on mechanisms of action of fluorine compounds on the cellular and subcellular level.


CONCLUSIONS
Finally, two achievements of recent years in the field of fluorine research are discussed briefly. The first is concerned with the use in dentistry of chemical analysis for studying mineral reconstruction of teeth throughout the lifetime of an individual. The second is in the field of medicine where molecular modeling has been applied to explain the mechanism of action of aluminofluoride complexes (AlFx) as a messenger of false information during protein biosynthesis and their apparent role in the etiology of Alzheimer's disease.
Machoy-Mokrzyńska
Anna
A
Katedra Farmakologii Pomorskiej Akademii Medycznej al. Powstańców Wlkp. 72, 70-111 Szczecin.
Machoy
Zygmunt
Z
D000818:Animals; D035843:Biomedical Research / Q000379:methods / Q000639:trends*; D005457:Fluoridation / Q000009:adverse effects*; D005458:Fluoride Poisoning / Q000453:epidemiology / Q000209:etiology / Q000503:physiopathology*; D005459:Fluorides / Q000032:analysis / Q000378:metabolism* / Q000633:toxicity; D017611:Fluorine Compounds / Q000032:analysis / Q000633:toxicity*; D006801:Humans; D011044:Poland; D014874:Water Pollutants, Chemical / Q000633:toxicity*
D017611:Fluorine Compounds; D014874:Water Pollutants, Chemical; D005459:Fluorides