[An emulsion based on 1-bromoperfluorooctane: X-ray contrast properties and mechanisms of X-ray contrasting].
It has been shown that the emulsion of a mixture of the perfluorocarbons 1-bromoperfluorooctane and perfluoro[1-(4-methylcyclohexyl)piperidine], stabilized by egg yolk phospholipids, makes it possible to contrast rapidly (beginning with the 10th minute) and for a long time (up to 5 days) the tissues of various organs, such as liver, spleen, adrenal glands, heart, and the peritoneal part of the aorta. The roentgenograms of rat organs in in vivo experiments were evaluated by computer-assisted morphodensitometry. The contrasting of organs at early terms of the circulation of emulsion in the body is related to a high concentration of 1-bromoperfluorooctane in the blood flow, and the contrasting at later terms is related to the accumulation of emulsion particles by cells of the reticuloendothelial system.
Sklifas
A N
AN
Chaplygina
S L
SL
Shekhtman
D G
DG
Kukushkin
N I
NI
D034841:Abdominal Cavity / Q000000981:diagnostic imaging; D000818:Animals; D003287:Contrast Media / Q000737:chemistry / Q000493:pharmacokinetics*; D004530:Egg Yolk / Q000737:chemistry; D004655:Emulsions; D005466:Fluorocarbons / Q000737:chemistry / Q000493:pharmacokinetics*; D008297:Male; D010743:Phospholipids / Q000737:chemistry; D011859:Radiography; D051381:Rats; D017208:Rats, Wistar; D014018:Tissue Distribution; D014965:X-Rays
D003287:Contrast Media; D004655:Emulsions; D005466:Fluorocarbons; D010743:Phospholipids