[Transport of minerals in renal tubules and its hormonal regulation].
Mineral transport in renal tubules plays important role in the maintenance of serum concentrations of electrolytes. Filtered calcium from glomeruli is passively reabsorbed in proximal tubules and ascending limb of Henle. Calcium is further reabsorbed in distal tubules mainly mediated by transient receptor potential vallinoid 5 (TRPV5). Parathyroid hormone (PTH) and 1,25-dihydroxyvitamin D stimulate this calcium reabsorption in distal tubules. Phosphate is reabsorbed in proximal tubules mediated by sodium-phosphate co-transporters. This proximal tubular phosphate reabsorption is inhibited by PTH and fibroblast growth factor (FGF) 23.
Fukumoto
Seiji
S
The University of Tokyo Hospital, Division of Nephrology and Endocrinology, Department of Medicine, Tokyo, Japan.
D001692:Biological Transport / Q000502:physiology; D002118:Calcium / Q000378:metabolism; D000089703:Fibroblast Growth Factor-23; D006801:Humans; D007684:Kidney Tubules / Q000378:metabolism*; D008903:Minerals / Q000378:metabolism*; D010710:Phosphates / Q000378:metabolism; D050916:TRPV Cation Channels / Q000502:physiology
C000717427:FGF23 protein, human; D008903:Minerals; D010710:Phosphates; D050916:TRPV Cation Channels; C492239:TRPV5 protein, human; D000089703:Fibroblast Growth Factor-23; D002118:Calcium