Leucine-rich repeat proteins of synapses.
Leucine-rich repeats (LRRs) are 20-29-aa motifs that mediate protein-protein interactions and are present in a variety of membrane and cytoplasmic proteins. Many LRR proteins with neuronal functions have been reported. Here, we summarize an emerging group of synaptic LRR proteins, which includes densin-180, Erbin, NGL, SALM, and LGI1. These proteins have been implicated in the formation, differentiation, maintenance, and plasticity of neuronal synapses.
Ko
Jaewon
J
National Creative Research Initiative Center for Synaptogenesis and Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Yuseong-Ku, Kuseong-Dong, Daejeon, Korea.
Kim
Eunjoon
E
D000818:Animals; D000090263:Leucine-Rich Repeat Proteins; D011506:Proteins / Q000378:metabolism*; D013569:Synapses / Q000502:physiology*
D000090263:Leucine-Rich Repeat Proteins; D011506:Proteins