title: Residential proximity to waste sites and industrial facilities and chromosomal anomalies in offspring.
abstract: A few studies have found chromosomal anomalies in offspring associated with a maternal residence near waste sites, but did not examine the effect of living near industrial facilities, and most combined specific anomalies into heterogeneous groups. With a case-control study design, we investigated whether maternal residential proximity to hazardous waste sites or industrial facilities with chemical air emissions was associated with chromosomal anomalies in births. Maternal residences of 2099 Texas births with chromosomal anomalies and 4368 control births without documented malformations were related to boundaries of hazardous waste sites and street addresses of industrial facilities through geographic information systems. With adjustment for maternal age, race/ethnicity, and education, maternal residence within 1mile of a hazardous waste site (relative to farther away) was not associated with chromosomal anomalies in offspring except for Klinefelter variants among Hispanic births (odds ratios (OR) 7.9, 95% confidence interval (CI) 1.1-42.4). Women 35 years or older who lived within 1mile of industries with emissions of heavy metals were two times more likely (95% CI 1.1-4.1) than women living farther away to have offspring with chromosomal anomalies including trisomies 13, 18, or 21 or sex chromosome abnormalities. Among women 40 years or older, maternal residence within a mile of industries with solvent emissions was associated with chromosomal anomalies in births (OR 4.8, 95% CI 1.2-42.8). Study findings suggest some relation between residential proximity to industries with emissions of solvents or heavy metals and chromosomal anomalies in births to older mothers.
authors.affiliation: Department of Epidemiology and Biostatistics, Texas A&M Health Science Center School of Rural Public Health, College Station, TX 77843-1266, USA. jdbrender@srph.tamhsc.edu
authors.forename: Jean D
authors.initials: JD
authors.lastname: Brender
authors.forename: F Benjamin
authors.initials: FB
authors.lastname: Zhan
authors.forename: Peter H
authors.initials: PH
authors.lastname: Langlois
authors.forename: Lucina
authors.initials: L
authors.lastname: Suarez
authors.forename: Angela
authors.initials: A
authors.lastname: Scheuerle
mesh_terms: D000328:Adult; D000393:Air Pollutants / Q000009:adverse effects*; D016022:Case-Control Studies; D002869:Chromosome Aberrations / Q000139:chemically induced*; D025063:Chromosome Disorders / Q000139:chemically induced* / Q000453:epidemiology; D005260:Female; D040362:Geographic Information Systems; D006256:Hazardous Waste / Q000009:adverse effects*; D006801:Humans; D007220:Industrial Waste / Q000009:adverse effects*; D007231:Infant, Newborn; D008423:Maternal Age; D018811:Maternal Exposure / Q000009:adverse effects*; D011247:Pregnancy; D012111:Residence Characteristics; D025064:Sex Chromosome Disorders / Q000139:chemically induced / Q000453:epidemiology; D013781:Texas / Q000453:epidemiology
chemical_list: D000393:Air Pollutants; D006256:Hazardous Waste; D007220:Industrial Waste