title: Ovarian dysgerminomas in two mountain chicken frogs (Leptodactylus fallax).
abstract: This report describes the gross, histologic, and immunohistochemical features of ovarian dysgerminomas in two adult female mountain chicken frogs (Leptodactylusfallax) from the same zoological institution. One frog was found dead, and the other frog had been ill for several days with a bloated abdomen and lethargy. On necropsy, large, pale multilobulated masses replaced the left ovary in both frogs, and one frog also had numerous smaller nodules scattered throughout the coelomic viscera. Histologically, these masses were composed of sheets and cords of polyhedral discrete germ cells consistent with the diagnosis of dysgerminoma. Neoplastic cells stained positive with immunohistochemistry for Oct4, which has been reported to detect stem cells including germ cells in a variety of species, including humans. Ovarian tumors are uncommonly encountered in both reptiles and amphibians, and this report is the first report of dysgerminoma in any amphibian species.
authors.affiliation: Diagnostic Center for Population and Animal Health, Michigan State University, Lansing 48910, USA.
authors.forename: Scott D
authors.initials: SD
authors.lastname: Fitzgerald
authors.forename: Ann E
authors.initials: AE
authors.lastname: Duncan
authors.forename: Chris
authors.initials: C
authors.lastname: Tabaka
authors.forename: Michael M
authors.initials: MM
authors.lastname: Garner
authors.forename: April
authors.initials: A
authors.lastname: Dieter
authors.forename: Matti
authors.initials: M
authors.lastname: Kiupel
mesh_terms: D000818:Animals; D000836:Animals, Zoo; D001001:Anura; D014408:Biomarkers, Tumor / Q000032:analysis; D004407:Dysgerminoma / Q000473:pathology / Q000662:veterinary*; D017809:Fatal Outcome; D005260:Female; D009362:Neoplasm Metastasis; D050810:Octamer Transcription Factors / Q000032:analysis; D010051:Ovarian Neoplasms / Q000473:pathology / Q000662:veterinary*
chemical_list: D014408:Biomarkers, Tumor; D050810:Octamer Transcription Factors