title: In vitro hypoglycemic and antimicrobial activities of Senecio leucanthemifolius Poiret.
abstract: This study reports on the alpha-amylase inhibitory and antimicrobial activities of Senecio leucanthemifolius Poiret. Extracts of S. leucanthemifolius were tested for their antimicrobial and antifungal activities against seven different pathogenic microorganisms using the microdilution technique. The ethyl acetate extract exhibited a strong antibiotic activity against Staphylococcus aureus with a MIC value of 31.25 microg mL(-1), while the n-hexane extract showed a significant activity against dermatophytic fungi. S. leucanthemifolius extracts were tested also for their potential hypoglycemic activity through the in vitro inhibition of alpha-amylase. The dichloromethane extract inhibited alpha-amylase with a value of 56.6% at 0.05 mg mL(-1) and the n-butanol extract showed a value of 89.2% at 1 mg mL(-1).
authors.affiliation: Department of Pharmaceutical Sciences, University of Calabria, Rende (CS), Italy. rosa.tundis@unical.it
authors.forename: R
authors.initials: R
authors.lastname: Tundis
authors.forename: M R
authors.initials: MR
authors.lastname: Loizzo
authors.forename: G A
authors.initials: GA
authors.lastname: Statti
authors.forename: P J
authors.initials: PJ
authors.lastname: Houghton
authors.forename: A
authors.initials: A
authors.lastname: Miljkovic-Brake
authors.forename: F
authors.initials: F
authors.lastname: Menichini
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D008864:Microsporum / Q000187:drug effects; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D012674:Senecio / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects; D014249:Trichophyton / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D007004:Hypoglycemic Agents; D010936:Plant Extracts