title: Adjunct duties for karyopherins: regulating septin sumoylation.
abstract: Karyopherins are shuttling transport receptors regulated by the small GTPase Ran, which move cargo between the nucleus and cytoplasm by passing through the nuclear pore complexes. A recent paper in Journal of Cell Biology (Makhnevych et al., 2007) highlights an additional role for karyopherins during mitosis, in regulating the sumoylation status of the septin rings.
authors.affiliation: Institute of Biochemistry (IBC), Schafmattstrasse 18, ETH Zürich, CH-8093 Zürich, Switzerland.
authors.forename: Vikram Govind
authors.initials: VG
authors.lastname: Panse
authors.forename: Ed
authors.initials: E
authors.lastname: Hurt
mesh_terms: D003546:Cysteine Endopeptidases / Q000378:metabolism; D003598:Cytoskeletal Proteins / Q000378:metabolism*; D028884:Karyopherins / Q000378:metabolism*; D022022:Nuclear Pore / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000201:enzymology / Q000378:metabolism*; D025841:Small Ubiquitin-Related Modifier Proteins / Q000378:metabolism*
chemical_list: D003598:Cytoskeletal Proteins; D028884:Karyopherins; D025841:Small Ubiquitin-Related Modifier Proteins; D003546:Cysteine Endopeptidases; C118083:Ulp1 protease