title: Nightly high dose lactulose infusion could be a cost-effective treatment for hepatic encephalopathy, renal insufficiency and heart failure.
abstract: Lactulose is an established remedy for hepatic encephalopathy and shows efficacy for chronic renal insufficiency, reducing volume overload, uremia and hyperkalemia. Potentially lactulose could also be used for non-diuretic treatment of congestive heart failure. However, use of lactulose is limited by diarrhea and flatulence. Chronic lactulose administration might be tolerable if it was accomplished by nocturnal infusion through a percutaneous duodenostomy tube, also placing a rectal foley each night following a clearing enema so that large volumes of liquid stool could be passed while patients sleep. Each morning the duodenostomy would be clamped and the foley removed. For acute patients without duodenostomies, a temporary dobhoff feeding tube with accompanying rectal foley could be employed. Patients who did not want a rectal foley could elect to have a permanent colostomy. Clinical trials could establish the relationship between lactulose infusion and clearance of water, salt, potassium, hydrogen, urea and other wastes, and compare efficacy, cost and tolerability with that of peritoneal dialysis and ultrafiltration. Lactulose could potentially allow inexpensive home-based therapy for hepatic encephalopathy, chronic renal failure and congestive heart failure, and might be life-saving in countries where renal replacement in any form is currently unavailable.
authors.affiliation: Marshfield Clinic Research Foundation, 1000 Oak Avenue, Marshfield, WI 54449, USA. Alisky.Joseph@marshfieldclinic.org
authors.forename: Joseph Martin
authors.initials: JM
authors.lastname: Alisky
mesh_terms: D002303:Cardiac Output, Low / Q000188:drug therapy* / Q000191:economics*; D003362:Cost-Benefit Analysis; D004334:Drug Administration Schedule; D006501:Hepatic Encephalopathy / Q000188:drug therapy* / Q000191:economics*; D006801:Humans; D007262:Infusions, Intravenous / Q000191:economics; D007792:Lactulose / Q000008:administration & dosage* / Q000191:economics*; D051437:Renal Insufficiency / Q000188:drug therapy* / Q000191:economics*
chemical_list: D007792:Lactulose