title: Effect of simvastatin use on bone mineral density in women with type 2 diabetes.
abstract: OBJECTIVE
  To attempt to clarify the effect of simvastatin, a widely used statin, on the bone mineral density in women with type 2 diabetes.
  
  
  METHODS
  We performed a cross-sectional, controlled study of 37 women with type 2 diabetes who were taking simvastatin. Each woman was matched with 2 control subjects who were closest in age, years since menopause (if applicable), and duration of diabetes on the date on which the examination was performed. We measured bone mineral density at the spine and the hip with a dual-energy xray absorptiometry scanner and compared bone density in the 2 study groups.
  
  
  RESULTS
  The mean bone mineral density values of patients in the simvastatin group were found to be slightly increased in comparison with those of the control group, both in the lumbar vertebrae and in the femoral neck, but these differences were not statistically significant (P>0.05).
  
  
  CONCLUSIONS
  In this cross-sectional study, we could not demonstrate a positive effect of long-term simvastatin treatment on bone mineral density in women with type 2 diabetes and hypercholesterolemia.
authors.affiliation: Department of Endocrinology and Metabolism, Ankara University School of Medicine, Ankara, Turkey.
authors.forename: Ali Riza
authors.initials: AR
authors.lastname: Uysal
authors.forename: Tuncay
authors.initials: T
authors.lastname: Delibasi
authors.forename: Murat F
authors.initials: MF
authors.lastname: Erdogan
authors.forename: Nuri
authors.initials: N
authors.lastname: Kamel
authors.forename: Nilgun
authors.initials: N
authors.lastname: Baskal
authors.forename: Vedia
authors.initials: V
authors.lastname: Tonyukuk
authors.forename: Demet
authors.initials: D
authors.lastname: Corapcioglu
authors.forename: Sevim
authors.initials: S
authors.lastname: Güllü
authors.forename: Gurbuz
authors.initials: G
authors.lastname: Erdogan
mesh_terms: D015502:Absorptiometry, Photon; D000368:Aged; D015519:Bone Density / Q000187:drug effects*; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy* / Q000378:metabolism; D005260:Female; D005500:Follow-Up Studies; D006621:Hip Joint / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D006937:Hypercholesterolemia / Q000188:drug therapy / Q000378:metabolism; D000960:Hypolipidemic Agents / Q000494:pharmacology / Q000627:therapeutic use; D008875:Middle Aged; D019821:Simvastatin / Q000494:pharmacology / Q000627:therapeutic use*; D013131:Spine / Q000187:drug effects / Q000378:metabolism; D013997:Time Factors
chemical_list: D000960:Hypolipidemic Agents; D019821:Simvastatin