title: Failure of intracameral fluorouracil to resolve an epithelial ingrowth following clear corneal cataract surgery.
abstract: We present a case of epithelial ingrowth that progressed despite repeated intracameral injections of fluorouracil (5-FU). Six months after cataract surgery, a retrocorneal membrane was found advancing from the corneal section. At 1 year, 0.5 mg of 5-FU in 0.1 mL of balanced salt solution was exchanged for 0.1 mL of aqueous. Ingrowth initially stopped, but progressed 6 months later. Two further injections of 0.5 mg of 5-FU were given at 1-month intervals, followed by 1 mg of 5-FU 3 and 6 months later. Each injection initially halted progression of the ingrowth, but then it recurred. Ultimately, the treatment failed to prevent progression of the disease and angle-closure glaucoma ensued. Resolution of epithelial ingrowth with intracameral 5-FU has been reported twice. We found no reports of such treatment following clear corneal cataract surgery or with eventual epithelial ingrowth progression. Epithelial ingrowth remains a relentless and challenging condition to treat.
authors.affiliation: Ophthalmology Department, Sandwell General Hospital, Lyndon, West Bromwich, West Midlands, United Kingdom. paultomlins@mac.com
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Tomlins
authors.forename: Vijay
authors.initials: V
authors.lastname: Savant
authors.forename: Michael
authors.initials: M
authors.lastname: Quinlan
mesh_terms: D000963:Antimetabolites / Q000627:therapeutic use*; D002387:Cataract Extraction; D003316:Corneal Diseases / Q000175:diagnosis / Q000188:drug therapy*; D019573:Epithelium, Corneal / Q000187:drug effects* / Q000473:pathology; D005472:Fluorouracil / Q000627:therapeutic use*; D015812:Glaucoma, Angle-Closure / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D012008:Recurrence; D017211:Treatment Failure
chemical_list: D000963:Antimetabolites; D005472:Fluorouracil