[Influence of DNA damage on fertilizing capacity of spermatozoa].
DNA damage in the male germ line cells is correlated with male infertility. Nuclear DNA damage in mature sperm includes single strand nicks and double strand breaks that can arise as a consequence of errors in chromatin rearrangement during spermiogenesis, abortive apoptosis, and oxidative stress. Methods of assisted reproduction may be connected with a risk of the using of sperm with impaired DNA integrity that can lead to spontaneous abortion or delivery of a child with congenital abnormalities.
Sikora
Jacek
J
Katedra i Zakład Biochemii i Biologii Molekularnej Akademii Medycznej im. K. Marcinkowskiego w Poznaniu.
Kempisty
Bartosz
B
Jedrzejczak
Piotr
P
Jagodziński
Paweł P
PP
D000022:Abortion, Spontaneous / Q000209:etiology; D000818:Animals; D017209:Apoptosis; D002648:Child; D004249:DNA Damage / Q000502:physiology; D053938:DNA Fragmentation; D005260:Female; D006801:Humans; D007248:Infertility, Male / Q000150:complications / Q000235:genetics*; D008297:Male; D011247:Pregnancy; D017382:Reactive Oxygen Species / Q000378:metabolism; D020554:Sperm Injections, Intracytoplasmic / Q000379:methods; D013094:Spermatozoa / Q000473:pathology / Q000502:physiology / Q000648:ultrastructure*
D017382:Reactive Oxygen Species