title: Osteocalcin in serum, saliva and gingival crevicular fluid: their relation with periodontal treatment outcome in postmenopausal women.
abstract: BACKGROUND
  Osteocalcin levels have been postulated as a marker of inhibition of bone formation. The aim of the present study was to assess plasma, saliva and GCF levels of osteocalcin and correlate them with periodontal treatment outcome in postmenopausal women.
  
  
  METHODS
  Thirty-nine postmenopausal women (57.8 -/+8.5 years old) were recruited for the study. Periodontal examination of all women was carried out and plaque, bleeding on probing, probing depth (PD), and clinical attachment level (CAL) were recorded. Serum, saliva and gingival crevicular fluid osteocalcin were measured. Then, periodontal treatment was carried out. Six months after the first appointment a second periodontal examination was carried out.
  
  
  RESULTS
  Mean PD and mean CAL decreased significantly at second appointment in the group with serum osteocalcin concentration <10 ng/ml (15.8 -/+15.8% and 15.3 -/+ 21.2% respectively; p < 0.05). Mean PD decreased significantly at second appointment in the groups with saliva osteocalcin concentration < 3 ng/ml (17.1 -/+ 15.9%; p < 0.05) and 3-7 ng/ml (16.2 -/+18.1%; p < 0.05).
  
  
  CONCLUSIONS
  Low serum osteocalcin concentration is associated to a significantly higher percentage of decrease in PD and CAL after periodontal treatment in postmenopausal women. Low saliva osteocalcin concentrations are significantly associated to a higher percentage of decrease in PD.
authors.affiliation: Periodontics Department, School of Medicine, University of Sevilla, Sevilla, Spain. pbullon@us.es
authors.forename: Pedro
authors.initials: P
authors.lastname: Bullon
authors.forename: Lucy
authors.initials: L
authors.lastname: Chandler
authors.forename: Juan J
authors.initials: JJ
authors.lastname: Segura Egea
authors.forename: Ramón
authors.initials: R
authors.lastname: Perez Cano
authors.forename: Angel
authors.initials: A
authors.lastname: Martinez Sahuquillo
mesh_terms: D000704:Analysis of Variance; D015415:Biomarkers / Q000032:analysis / Q000097:blood; D005260:Female; D005883:Gingival Crevicular Fluid / Q000737:chemistry*; D005888:Gingival Pocket / Q000175:diagnosis; D006801:Humans; D008875:Middle Aged; D015675:Osteocalcin / Q000032:analysis* / Q000097:blood; D017622:Periodontal Attachment Loss / Q000175:diagnosis; D010510:Periodontal Diseases / Q000628:therapy*; D010518:Periodontitis / Q000628:therapy; D017698:Postmenopause; D012463:Saliva / Q000737:chemistry*
chemical_list: D015415:Biomarkers; D015675:Osteocalcin