title: Is there any relationship between proinflammatory mediator levels in disc material and myelopathy with cervical disc herniation and spondylosis? A non-randomized, prospective clinical study.
abstract: The proinflammatory mediator (PIM) levels were assessed in surgically removed samples of herniated cervical intervertebral discs. The objective of this study was to investigate if there is a correlation between the levels of PIMs in disc material and myelopathy associated with cervical intervertebral disc herniation and spondylosis. The role of proinflammatory mediators in the degeneration of intervertebral disc and the inflammatory effects of disc herniations on radicular pain has been previously published. However, the possible relationship between PIMs and myelopathy related to cervical disc herniation and spondylosis has not been investigated before. Thirty-two patients undergoing surgery for cervical disc herniation and spondylosis were investigated. Surgically obtained disc materials, stored at 70 degrees C, were classified into two groups: cervical disc herniation alone or with myelopathy. Biochemical preparation and solid phase enzyme amplified sensitivity immunoassay (ELISIA) analysis of the samples were performed to assess the concentration of mediators in the samples. Very similar values of interleukin-6 were found in both groups whereas the concentrations of mediators were significantly higher in myelopathy group. This study has demonstrated that PIMs are involved in cervical intervertebral disc degeneration with higher concentrations in the samples associated with myelopathy.
authors.affiliation: Department of Neurosurgery, GATA Haydarpasa Training Hospital, 34668 Istanbul, Turkey. mehmetnusretdemircan@yahoo.com
authors.forename: Mehmet Nusret
authors.initials: MN
authors.lastname: Demircan
authors.forename: Alparslan
authors.initials: A
authors.lastname: Asir
authors.forename: Ahmet
authors.initials: A
authors.lastname: Cetinkal
authors.forename: Nursal
authors.initials: N
authors.lastname: Gedik
authors.forename: Ahmet Murat
authors.initials: AM
authors.lastname: Kutlay
authors.forename: Ahmet
authors.initials: A
authors.lastname: Colak
authors.forename: Sedat
authors.initials: S
authors.lastname: Kurtar
authors.forename: Hakan
authors.initials: H
authors.lastname: Simsek
mesh_terms: D000328:Adult; D002574:Cervical Vertebrae / Q000378:metabolism* / Q000473:pathology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007249:Inflammation / Q000150:complications; D007403:Intervertebral Disc / Q000378:metabolism*; D007405:Intervertebral Disc Displacement / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D013118:Spinal Cord Diseases / Q000209:etiology* / Q000378:metabolism*; D013128:Spinal Osteophytosis / Q000209:etiology* / Q000378:metabolism