A 59-kD renal antigen as a new target for rapidly progressive glomerulonephritis.
Anti-glomerular basement membrane (anti-GBM) antibodies are the hallmark of anti-GBM disease, which is characterized by rapidly progressive glomerulonephritis. We describe the case of a 58-year-old woman who presented with rapidly progressive glomerulonephritis with typical anti-GBM staining found by means of direct immunofluorescence microscopy, associated with linear immunoglobin G deposits on tubules. Serum analysis showed circulating anti-tubular basement membrane antibodies, but failed to detect anti-GBM antibodies. Immunoblotting showed that serum antibodies reacted with a 59-kd antigen found along both the GBM and tubular basement membrane.
Audard
Vincent
V
Institut de recherche en néphrologie et transplantation d'Ile de France, Henri Mondor Hospital, Paris, France. vincent.audard@hmn.ap-hop-paris.fr <vincent.audard@hmn.ap-hop-paris.fr>
Hellmark
Thomas
T
El Karoui
Khalil
K
Noël
Laure Hélène
LH
Pardon
Agathe
A
Desvaux
Dominique
D
Touchard
Guy
G
Remy
Philippe
P
Lang
Philippe
P
Sahali
Djillali
D
D019867:Anti-Glomerular Basement Membrane Disease / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology*; D001324:Autoantigens / Q000276:immunology / Q000378:metabolism*; D018450:Disease Progression; D005260:Female; D006801:Humans; D007684:Kidney Tubules / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged
D001324:Autoantigens; D008775:Methylprednisolone