[Hypoxia-inducible factor 1 and prostate cancer].
Hypoxia-inducible factor 1 (HIF-1) has a close relation with prostate cancer. It is involved not only in angiogenesis, cell proliferation/survival and glucose metabolism but also in p53, p21 and signal transduction pathway in prostate cancer. Further studies of HIF-1 may yield new approaches to the diagnosis and treatment of prostate cancer. We present a review of the structure and biological functions of HIF-1 and its relation with prostate cancer.
Pan
Zhou-hui
ZH
Department of Urology, the Third Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan 450052, China. doctorpzh@163.com
Chen
Zhao-dian
ZD
D006801:Humans; D051793:Hypoxia-Inducible Factor 1 / Q000502:physiology*; D008297:Male; D011471:Prostatic Neoplasms / Q000175:diagnosis / Q000378:metabolism / Q000628:therapy
D051793:Hypoxia-Inducible Factor 1