title: P(b)(P(1)) resonance at 40 Hz: effects of high stimulus rate on auditory middle latency responses (MLRs) explored using deconvolution.
abstract: OBJECTIVE
  In this study, the effects of high stimulus rate on middle latency response (MLR) components P(a) and P(b) (P(1) or P50) were studied using high rate clicks in normal hearing awake subjects were investigated.
  
  
  METHODS
  Five jittered click sequences at different mean rates (24.4, 39.1, 58.6, 78.1, 97.7Hz) were presented to 10 subjects. Overlapping MLRs were deconvolved using the frequency domain continuous loop averaging deconvolution (CLAD) [Ozdamar O., Bohórquez, J., Signal to noise ratio and frequency analysis of continuous loop averaging deconvolution (CLAD) of overlapping evoked potentials. J. Acoust. Soc. Am., 119:429-438, 2006]. In addition conventional auditory transient MLRs at 4.88Hz were obtained using conventional averaging.
  
  
  RESULTS
  P(a) amplitude, latency and waveshape remained fairly constant up to 78.1Hz. P(b) component, however, showed a variable waveshape with latencies covering a wide range (50-70ms) and N(b)-P(b) amplitudes increasing at 39.1 and 58.6Hz and decreasing at other rates.
  
  
  CONCLUSIONS
  Recordings show that both P(a) and P(b) MLR components can be consistently recorded at all rates up to 100Hz. P(b) amplitude shows an increase at around 40Hz showing a resonance at that frequency.
  
  
  CONCLUSIONS
  The dramatic increase of the P(b) component at around 40Hz may account for the high amplitude of the 40Hz ASSR.
authors.affiliation: Department of Biomedical Engineering, University of Miami, Coral Gables, FL 33124, USA. oozdamar@miami.edu
authors.forename: Ozcan
authors.initials: O
authors.lastname: Ozdamar
authors.forename: Jorge
authors.initials: J
authors.lastname: Bohórquez
authors.forename: Saumitra Sinha
authors.initials: SS
authors.lastname: Ray
mesh_terms: D000161:Acoustic Stimulation; D004056:Differential Threshold; D004307:Dose-Response Relationship, Radiation; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D006801:Humans; D011930:Reaction Time / Q000502:physiology*