Identification of four new HLA-Cw alleles in the Sudanese population.
The major histocompatibility complex (MHC) is the most polymorphic region of the human genome. Human leukocyte antigen-C (HLA-C) genes are located in the class I region of MHC. Most polymorphisms of HLA class I antigens are present in exons 2 and 3, which encode the alpha1 and alpha2 domains of the HLA-A heavy chain, involved in both peptide binding and HLA-restricted recognition by the T-cell receptor. Four new HLA-Cw alleles were identified in the Sudanese population during HLA class I and class II sequencing-based typing at the HLA-C locus of case-control study of Sudanese HIV patients, in individuals from different ethnic background. Based on the localization of the affected amino acid positions in an outer loop of the alpha-helix forming the side of the peptide-binding groove, we do not expect the replacement mutations to have an effect on peptide binding or T-cell receptor interaction.
Elamin
N E
NE
Institute for Transfusion Medicine, Hannover Medical School, Hannover, Germany.
Elbashir
M I
MI
Elkhidir
I M
IM
Elghazali
G
G
Blasczyk
R
R
Horn
P A
PA
D000483:Alleles; D016022:Case-Control Studies; D005260:Female; D015236:HLA-C Antigens / Q000235:genetics*; D006801:Humans; D008297:Male; D017433:Protein Structure, Secondary / Q000235:genetics; D017434:Protein Structure, Tertiary / Q000235:genetics; D013397:Sudan
D015236:HLA-C Antigens