IQGAP1 and IGFBP2: valuable biomarkers for determining prognosis in glioma patients.
Clinical treatment decisions and the survival outcomes of patients with gliomas are directly impacted by accurate tumor classification. New and more reliable prognostic markers are needed to better identify the variable duration of survival among histologically defined glioma grades. Microarray expression analysis and immunohistochemistry were used to identify biomarkers associated with gliomas with more aggressive biologic behaviors. The protein expression of IQGAP1 and IGFBP2, when used in conjunction with the World Health Organization grading system, readily identified and defined a subgroup of patients with grade III gliomas whose prognosis was poor. In addition, in patients with glioblastoma multiforme, in whom IQGAP1 and IGFBP2 were absent, long-term survival of more than 3 years was observed. The use of these markers confirmed a nonuniform distribution of survival in those with World Health Organization grade III and IV tumors. Thus, IQGAP1 and IGFBP2 immunostaining supplements current histologic grading by offering additional prognostic and predictive information.
McDonald
Kerrie L
KL
Cancer Genetics, Kolling Institute of Medical Research, St. Leonards, New South Wales, Australia. kerriem@med.usyd.edu.au
O'Sullivan
Maree G
MG
Parkinson
Jonathon F
JF
Shaw
Janet M
JM
Payne
Cathy A
CA
Brewer
Janice M
JM
Young
Lawrence
L
Reader
Dianne J
DJ
Wheeler
Helen T
HT
Cook
Raymond J
RJ
Biggs
Michael T
MT
Little
Nicholas S
NS
Teo
Charlie
C
Stone
Glenn
G
Robinson
Bruce G
BG
D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000378:metabolism; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000378:metabolism*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D005910:Glioma / Q000175:diagnosis* / Q000378:metabolism*; D006801:Humans; D018971:Insulin-Like Growth Factor Binding Protein 2 / Q000235:genetics / Q000378:metabolism*; D008297:Male; D046228:Microarray Analysis / Q000379:methods; D008875:Middle Aged; D011379:Prognosis; D012333:RNA, Messenger / Q000096:biosynthesis; D012044:Regression Analysis; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000379:methods; D012720:Severity of Illness Index; D016019:Survival Analysis; D020703:ras GTPase-Activating Proteins / Q000235:genetics / Q000378:metabolism*
D015415:Biomarkers; C101203:IQ motif containing GTPase activating protein 1; D018971:Insulin-Like Growth Factor Binding Protein 2; D012333:RNA, Messenger; D020703:ras GTPase-Activating Proteins