title: Targeting tumors with hypoxia-activated cytotoxins.
abstract: This review focuses on the recent development of hypoxia-activated cytotoxins. Such drugs are prodrugs activated to cytotoxic products in the hypoxic environment of solid tumors (so-called "bioreductive prodrugs"), but can also be activated by radiation (radiation-activated prodrugs). These compounds grew out of research on hypoxic radiosensitizers, which are compounds that can overcome the radiation resistance of hypoxic cells, and we will discuss this area also. The advantages and limitations of each class of the hypoxia-activated cytotoxins are discussed. In addition we will discuss a novel method of targeting drugs to tumors based on anaerobic bacteria, the so-called "clostridia-directed enzyme prodrug therapy" or CDEPT, which also exploits the hypoxic environment of solid tumors.
authors.affiliation: Division of Radiation and Cancer Biology, Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305-5152, USA.
authors.forename: G-One
authors.initials: GO
authors.lastname: Ahn
authors.forename: Martin
authors.initials: M
authors.lastname: Brown
mesh_terms: D003603:Cytotoxins / Q000378:metabolism / Q000627:therapeutic use*; D015316:Genetic Therapy; D006801:Humans; D000860:Hypoxia; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000628:therapy; D011355:Prodrugs / Q000627:therapeutic use; D011838:Radiation-Sensitizing Agents / Q000627:therapeutic use
chemical_list: D003603:Cytotoxins; D011355:Prodrugs; D011838:Radiation-Sensitizing Agents