TRP channel knockout mice lose their cool.
Heat and cold transduction by peripheral sensory neurons is a fundamental step in the avoidance of dangerous thermal extremes. In this issue of Neuron, Dhaka et al. and Colburn et al. report that mice lacking the cold- and menthol-gated ion channel TRPM8 exhibit deficient behavioral responses to cold temperatures.
Chung
Man-Kyo
MK
Department of Biological Chemistry, Center for Sensory Biology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
Caterina
Michael J
MJ
D000818:Animals; D003080:Cold Temperature; D051379:Mice; D018345:Mice, Knockout / Q000502:physiology*; D050053:TRPM Cation Channels / Q000172:deficiency*; D013697:Thermosensing / Q000235:genetics*
D050053:TRPM Cation Channels; C492297:TRPM8 protein, mouse