New cytotoxic cembranolides from the soft coral Lobophytum michaelae.
Eleven new cytotoxic cembranolides, michaolides A-K (1-11), and crassolide (12) were isolated from the CH(2)Cl(2) extract of the Formosan soft coral Lobophytum michaelae. Their structures were established by extensive spectral analysis. The cytotoxicity of the isolates against selected cancer cells was measured in vitro.
Wang
Li-Tang
LT
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung, 804 Taiwan.
Wang
Shang-Kewi
SK
Soong
Keryea
K
Duh
Chang-Yih
CY
D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000302:isolation & purification* / Q000494:pharmacology*; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000302:isolation & purification* / Q000494:pharmacology*; D019073:HT29 Cells; D006801:Humans; D007783:Lactones / Q000302:isolation & purification* / Q000494:pharmacology*; D007941:Leukemia P388 / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D019086:Bridged Bicyclo Compounds, Heterocyclic; D007783:Lactones