title: The effects of soygerm extracts on blood lipoproteins, antioxidative capacity and urinary estrogen metabolites in postmenopausal women on hormone therapy.
abstract: OBJECTIVE
  To evaluate the effects of soygerm isoflavones extracts on blood lipoproteins, antioxidative capacity and urinary estrogen metabolites in postmenopausal women who receive hormone therapy (HT).
  
  
  METHODS
  Thirty-nine volunteers receiving HT were recruited, and 33 completed the study. All subjects received 6 g of soygerm extracts per day for 4 weeks. Blood and urine samples were collected for study at the beginning and at the end of study.
  
  
  RESULTS
  Plasma HDL-C levels increased markedly with significant decreases of plasma LDL-C/HDL-C ratio and LDL-TG levels. The lag time of conjugated dienes formation prolonged for 9.9% and thiobarbituric acid reactive substances production in copper-catalyzed oxidation of LDL decreased. The differences were statistically significant. Urinary ratio of 2-OHE(1) to 16alpha-OHE(1) increased without statistical significance.
  
  
  CONCLUSIONS
  Soygerm extracts may improve serum lipid profile in postmenopausal Taiwanese women who receive HT, and probably provide a favorable effect on estrogen metabolism.
authors.affiliation: Department of Child and Family Studies, Fu-Jen Catholic University, Taiwan.
authors.forename: I P
authors.initials: IP
authors.lastname: Hsu
authors.forename: H J
authors.initials: HJ
authors.lastname: Jou
authors.forename: C W
authors.initials: CW
authors.lastname: Huang
authors.forename: T A
authors.initials: TA
authors.lastname: Wang
authors.forename: W H
authors.initials: WH
authors.lastname: Wu
mesh_terms: D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D008076:Cholesterol, HDL / Q000097:blood / Q000187:drug effects; D008078:Cholesterol, LDL / Q000097:blood / Q000187:drug effects; D003300:Copper; D015914:Estrogen Replacement Therapy; D004967:Estrogens / Q000378:metabolism / Q000652:urine*; D005260:Female; D006801:Humans; D006894:Hydroxyestrones / Q000652:urine; D007529:Isoflavones / Q000737:chemistry / Q000494:pharmacology*; D008077:Lipoproteins, LDL / Q000097:blood / Q000187:drug effects; D008875:Middle Aged; D010084:Oxidation-Reduction; D010865:Pilot Projects; D010936:Plant Extracts / Q000494:pharmacology*; D017698:Postmenopause; D013025:Glycine max / Q000737:chemistry*; D013624:Taiwan; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D014280:Triglycerides / Q000097:blood
chemical_list: D000975:Antioxidants; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D004967:Estrogens; D006894:Hydroxyestrones; D007529:Isoflavones; D008077:Lipoproteins, LDL; D010936:Plant Extracts; D017392:Thiobarbituric Acid Reactive Substances; D014280:Triglycerides; C032607:low density lipoprotein triglyceride; C026702:16-hydroxyestrone; D003300:Copper; C024980:2-hydroxyestrone