Design and total synthesis of unnatural analogues of the sub-nanomolar SERCA inhibitor thapsigargin.
Thapsigargin is a densely oxygenated guaianolide which displays potent sarco/endoplasmic reticulum Ca(2+) ATPase (SERCA) binding affinities. The total syntheses of designed unnatural analogues of this important natural product are described. This article constitutes the chemical synthesis behind an ongoing project. Rational modifications have been made to the lactone region of thapsigargin in order to obtain derivatives for future structure-activity relationship studies.
Andrews
Stephen P
SP
University Chemical Laboratory, Lensfield Road, Cambridge, CB2 1EW, UK.
Tait
Malcolm M
MM
Ball
Matthew
M
Ley
Steven V
SV
D015107:4-Butyrolactone / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000737:chemistry; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D053498:Sarcoplasmic Reticulum Calcium-Transporting ATPases / Q000037:antagonists & inhibitors*; D019284:Thapsigargin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*
D004791:Enzyme Inhibitors; D019284:Thapsigargin; C004511:butenolide; D053498:Sarcoplasmic Reticulum Calcium-Transporting ATPases; D015107:4-Butyrolactone