Study of association between common variation in the insulin-like growth factor 2 gene and indices of obesity and body size in middle-aged men and women.
BACKGROUND
The IGF2 gene (IGF2) plays a key role in growth and is a candidate for association with obesity. Previous studies have reported that polymorphisms in IGF2 are associated with body weight and body mass index (BMI), but the results have been inconsistent.


OBJECTIVE
The aim of this study was primarily to confirm the association with BMI and, secondarily, to study the associations with other indices of body size.


METHODS
In a sample of 2797 women and 2203 men aged 39-79 participating in the Norfolk arm of the European Prospective Investigation of Cancer, we genotyped three single nucleotide polymorphisms (SNPs) in the IGF2 gene that were previously associated with BMI [6815 A/T, 1156 T/C (G/A), and 820 G/A (ApaI)].


RESULTS
No significant associations were observed between these SNPs and BMI. However, all three SNPs were significantly associated with height (P = 0.03 to 0.001). In a backward elimination regression analysis, two SNPs, 1156 T/C (G/A) and 820 G/A, remained independently associated with height (P = 0.003 and P = 0.038, respectively). Haplotype analysis of these two SNPs showed that carriers of the GA haplotype were shorter than carriers of each of the other three haplotypes (P < 0.001 for all comparisons).


CONCLUSIONS
We did not confirm the previously reported associations between IGF2 polymorphisms and BMI. However, our results suggest that common variation in the IGF2 gene may be associated with adult height. IGF2 could be considered as a candidate gene for future research on mechanisms for the association between height and chronic diseases, such as cancer, diabetes, and coronary heart disease.
Heude
Barbara
B
Medical Research Council Epidemiology Unit, Strangeways Research Laboratory, Cambridge CB1 8RN, United Kingdom. heude@vjf.inserm.fr
Ong
Ken K
KK
Luben
Robert
R
Wareham
Nicholas J
NJ
Sandhu
Manjinder S
MS
D000328:Adult; D000368:Aged; D001827:Body Height / Q000235:genetics*; D015992:Body Mass Index; D001835:Body Weight / Q000235:genetics; D005260:Female; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D007335:Insulin-Like Growth Factor II; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011446:Prospective Studies; D011506:Proteins / Q000235:genetics*; D012044:Regression Analysis
C035170:IGF2 protein, human; D011506:Proteins; D007335:Insulin-Like Growth Factor II