[Effect of corticoliberin fragment CRF4-6 on blood glucose level and body temperature of rats].
The effects of tripeptide corticoliberin fragment CRF4-6 (Pro-Pro-Ile) on blood glucose level and the rat body temperatire were investigated. Intracerebroventricularly injected CRF4-6 (6, 30, 150 nmol/head) causes a dosedependent hyperglycemia and hyperthermia in anaesthetized animals. Corticotropin releasing factor antagonist alpha-helical CRF4-6 (6.5 nmol/head) abolishes the influence of tripeptide CRF4-6 (6 nmol/head) on blood glucose level and body temperature of rats. Bilateral adrenalectomy has no effect on tripeptide-induced hyperglycemia and hyperthemia. This result indicates that hyperglycemic and hyperthermal effects of tripeptide occur independently of adrenal gland catecholamines. In addition, non-pituitary corticoliberin receptors are involved in CRF4-6 influences on blood glucose level and body temperature.
Makarenko
E Iu
EIu
Kondrashev-Lugovskiĭ
A S
AS
Andreeva
L A
LA
Mart'ianov
A A
AA
D000818:Animals; D001786:Blood Glucose / Q000187:drug effects*; D001831:Body Temperature / Q000187:drug effects; D003346:Corticotropin-Releasing Hormone / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005334:Fever / Q000097:blood* / Q000139:chemically induced; D006943:Hyperglycemia / Q000097:blood* / Q000139:chemically induced; D008297:Male; D010446:Peptide Fragments / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D051381:Rats; D018019:Receptors, Corticotropin-Releasing Hormone / Q000819:agonists / Q000378:metabolism*
D001786:Blood Glucose; D010446:Peptide Fragments; D018019:Receptors, Corticotropin-Releasing Hormone; C488808:prolyl-prolylisoleucine; D003346:Corticotropin-Releasing Hormone