title: An integrated tree-based classification approach to prognostic grouping with application to localized melanoma patients.
abstract: We propose an integrated tree-based approach for prognostic grouping of localized melanoma patients. This approach incorporates the survival tree model with the agglomerative hierarchical clustering to group terminal subgroups with similar prognoses together. The Brier score is used to evaluate the goodness of fit and the k-fold cross-validation test is used to evaluate the reproducibility of the scheme for prediction. The proposed approach is applied to an American Joint Committee on Cancer (AJCC) localized melanoma data set and compared with the current AJCC staging system. This approach performs more efficiently than the standard tree methods and has made improvement over the current AJCC melanoma staging system.
authors.affiliation: Institute of Statistical Science, Academia Sinica, Taipei, Taiwan.
authors.forename: Chen-An
authors.initials: CA
authors.lastname: Tsai
authors.forename: Dung-Tsa
authors.initials: DT
authors.lastname: Chen
authors.forename: James J
authors.initials: JJ
authors.lastname: Chen
authors.forename: Charles M
authors.initials: CM
authors.lastname: Balch
authors.forename: John F
authors.initials: JF
authors.lastname: Thompson
authors.forename: Seng-Jaw
authors.initials: SJ
authors.lastname: Soong
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D016000:Cluster Analysis; D003663:Decision Trees; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008545:Melanoma / Q000145:classification* / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology; D008875:Middle Aged; D009367:Neoplasm Staging / Q000379:methods*; D017410:Practice Guidelines as Topic; D011237:Predictive Value of Tests; D011379:Prognosis; D015203:Reproducibility of Results; D012878:Skin Neoplasms / Q000145:classification* / Q000175:diagnosis / Q000401:mortality / Q000473:pathology; D014481:United States