title: Adiponectin is a better predictor of endothelial function of the coronary artery than HOMA-R, body mass index, immunoreactive insulin, or triglycerides.
abstract: BACKGROUND
  Previous studies have demonstrated that decreased levels of circulating adiponectin correlate with endothelial dysfunction in peripheral arteries. However, the relationship between adiponectin levels and endothelial function in coronary arteries remains unclear. The goal of the present study was to determine whether circulating adiponectin concentrations are a useful predictor of coronary endothelial function.
  
  
  METHODS
  Thirty-six consecutive non-diabetic patients with normal or mildly diseased coronary arteries were enrolled in this study. Coronary endothelial function was evaluated by coronary vascular response to acetylcholine (Ach). The relationship between coronary vasoreactivity and adiponectin or other biochemical or anthropometric parameters was investigated. The predictive value of adiponectin level for assessment of coronary endothelial dysfunction was assessed at the best cut-off point.
  
  
  RESULTS
  In a simple regression analysis, log-transformed adiponectin concentrations positively correlated with the percent change in coronary blood flow (CBF) and coronary artery diameter (CAD) induced by Ach (r=0.62, p<0.0001; r=0.63, p<0.0001, respectively). Insulin resistance index (HOMA-R), body mass index, immunoreactive insulin, and triglycerides concentrations also significantly correlated with the percent change in CBF and CAD. However, in a multiple regression analysis, log-transformed adiponectin concentration was the only independent predictor of the percent change in CBF and CAD (p<0.0001; p<0.0001, respectively). Furthermore, patients with adiponectin concentrations <6.3 mg/L demonstrated coronary endothelial dysfunction with high specificity both in terms of CBF and CAD response (85%; 88%, respectively).
  
  
  CONCLUSIONS
  Adiponectin is a better predictor of coronary endothelial function than other factors such as HOMA-R, body mass index, immunoreactive insulin, and triglycerides.
authors.affiliation: Department of Cardiovascular, Respiratory and Metabolic Medicine, Graduate School of Medicine, Kagoshima University, 8-35-1, Sakuragaoka, Kagoshima 890-8520, Japan.
authors.forename: Hideki
authors.initials: H
authors.lastname: Okui
authors.forename: Shuichi
authors.initials: S
authors.lastname: Hamasaki
authors.forename: Sanemasa
authors.initials: S
authors.lastname: Ishida
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Kataoka
authors.forename: Koji
authors.initials: K
authors.lastname: Orihara
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Fukudome
authors.forename: Masakazu
authors.initials: M
authors.lastname: Ogawa
authors.forename: Naoya
authors.initials: N
authors.lastname: Oketani
authors.forename: Keishi
authors.initials: K
authors.lastname: Saihara
authors.forename: Takuro
authors.initials: T
authors.lastname: Shinsato
authors.forename: Takahiro
authors.initials: T
authors.lastname: Shirasawa
authors.forename: Etsuko
authors.initials: E
authors.lastname: Mizoguchi
authors.forename: Takuro
authors.initials: T
authors.lastname: Kubozono
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Ichiki
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Ninomiya
authors.forename: Takehiko
authors.initials: T
authors.lastname: Matsushita
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Nakasaki
authors.forename: Chuwa
authors.initials: C
authors.lastname: Tei
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000368:Aged; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D003326:Coronary Circulation / Q000502:physiology*; D003331:Coronary Vessels / Q000502:physiology*; D004730:Endothelium, Vascular / Q000502:physiology*; D005260:Female; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D007330:Insulin Antibodies / Q000096:biosynthesis / Q000097:blood*; D007333:Insulin Resistance / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D008955:Models, Cardiovascular; D011237:Predictive Value of Tests; D014280:Triglycerides / Q000097:blood*
chemical_list: D052242:Adiponectin; D015415:Biomarkers; D007330:Insulin Antibodies; D014280:Triglycerides