title: Targeted therapy and the T315I mutation in Philadelphia-positive leukemias.
authors.forename: Simona
authors.initials: S
authors.lastname: Soverini
authors.forename: Ilaria
authors.initials: I
authors.lastname: Iacobucci
authors.forename: Michele
authors.initials: M
authors.lastname: Baccarani
authors.forename: Giovanni
authors.initials: G
authors.lastname: Martinelli
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D019943:Amino Acid Substitution; D000970:Antineoplastic Agents / Q000493:pharmacokinetics* / Q000627:therapeutic use; D001549:Benzamides; D001555:Benzene Derivatives / Q000493:pharmacokinetics; D002986:Clinical Trials as Topic; D016503:Drug Delivery Systems; D015195:Drug Design; D019008:Drug Resistance, Neoplasm / Q000235:genetics*; D016044:Fusion Proteins, bcr-abl / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000235:genetics; D016313:Genes, abl; D006801:Humans; D006860:Hydrogen Bonding; D006877:Hydroxamic Acids / Q000493:pharmacokinetics / Q000627:therapeutic use; D000068877:Imatinib Mesylate; D007211:Indoles; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy* / Q000201:enzymology / Q000235:genetics; D020125:Mutation, Missense; D009281:Naphthalenes / Q000493:pharmacokinetics / Q000627:therapeutic use; D000077767:Panobinostat; D010677:Philadelphia Chromosome; D010879:Piperazines / Q000493:pharmacokinetics / Q000627:therapeutic use; D017354:Point Mutation; D011485:Protein Binding; D047428:Protein Kinase Inhibitors / Q000493:pharmacokinetics* / Q000627:therapeutic use; D011720:Pyrazoles / Q000493:pharmacokinetics / Q000627:therapeutic use; D011743:Pyrimidines / Q000493:pharmacokinetics / Q000627:therapeutic use; D012074:Remission Induction; D013329:Structure-Activity Relationship; D013912:Threonine / Q000737:chemistry; D000077337:Vorinostat; D003521:Cyclopropanes; D010671:Phenylurea Compounds
chemical_list: D000255:Adenosine Triphosphate; D000970:Antineoplastic Agents; D001549:Benzamides; D001555:Benzene Derivatives; D016044:Fusion Proteins, bcr-abl; D006877:Hydroxamic Acids; D000068877:Imatinib Mesylate; D007211:Indoles; D009281:Naphthalenes; D000077767:Panobinostat; D010879:Piperazines; D047428:Protein Kinase Inhibitors; D011720:Pyrazoles; D011743:Pyrimidines; D013912:Threonine; D000077337:Vorinostat; C499758:ON012380; C484810:tozasertib; D003521:Cyclopropanes; C452139:doramapimod; D010671:Phenylurea Compounds