title: An open-label, double tympanocentesis, single-center study of trimethoprim sulfametoxasole in children with acute otitis media.
abstract: Trimethoprim sulfamethoxasole has been recommended for the treatment of acute otitis media. In this double tympanocentesis study, children aged 3 to 48 months with acute otitis media received trimethoprim sulfamethoxasole twice daily (40 mg/kg/d) for 10 days. All children had a baseline tympanocentesis and in culture-positive children, tympanocentesis was repeated at the on-therapy visit. Of 89 children enrolled, 51 (57%) were clinically and bacteriologically evaluable. Bacteriologic eradication was achieved in 80% (42 of 52) of children, and overall clinical response at the end of therapy was 78%. Clinical success was 69% for culture-positive children versus 91% for culture-negative children at baseline tympanocentesis (P = 0.03). In this study, trimethoprim sulfamethoxasole clinical response was unsatisfactory, especially among culture-'positive children.
authors.affiliation: Instituto de Atención Pediftrica, San José, Costa Rica.
authors.forename: Carolina
authors.initials: C
authors.lastname: Soley
authors.forename: Adriano
authors.initials: A
authors.lastname: Arguedas
authors.forename: Silvia
authors.initials: S
authors.lastname: Guevara
authors.forename: Cecilia
authors.initials: C
authors.lastname: Loaiza
authors.forename: Guillermo
authors.initials: G
authors.lastname: Rincón
authors.forename: Alexandra
authors.initials: A
authors.lastname: Pérez
authors.forename: Eduardo
authors.initials: E
authors.lastname: Brilla
authors.forename: Wendy
authors.initials: W
authors.lastname: Porras
authors.forename: Jorge
authors.initials: J
authors.lastname: Arguedas
authors.forename: Hernán
authors.initials: H
authors.lastname: Sierra
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D006801:Humans; D010033:Otitis Media / Q000188:drug therapy*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use*
chemical_list: D000900:Anti-Bacterial Agents; D015662:Trimethoprim, Sulfamethoxazole Drug Combination