Synthesis and characterization of radiopaque magnetic core-shell nanoparticles for X-ray imaging applications.
Radiopaque magnetic gamma-Fe(2)O(3)/poly(2-methacryloyloxyethyl(2,3,5-triiodobenzoate)) core-shell nanoparticles of narrow size distribution were prepared by emulsion polymerization of the iodinated monomer 2-methacryloyloxyethyl(2,3,5-triiodobenzoate) in the presence of maghemite (gamma-Fe(2)O(3) nanoparticles coated with a dextran shell are commonly used as contrast agents for magnetic resonance imaging (MRI). The present nanoparticles have similar core-shell structure substituting the dextran for the iodo polymer. These core-shell nanoparticles may therefore be useful as imaging contrast agents to detect various pathogenic zones and to observe different disease states in both modes: X-ray and MRI.
Galperin
Anna
A
Department of Chemistry, Bar-Ilan University, Ramat-Gan 52900, Israel.
Margel
Shlomo
S
D003287:Contrast Media / Q000138:chemical synthesis / Q000737:chemistry*; D005290:Ferric Compounds / Q000737:chemistry*; D006801:Humans; D007455:Iodine / Q000737:chemistry; D008279:Magnetic Resonance Imaging; D008280:Magnetics; D008689:Methacrylates / Q000737:chemistry*; D008854:Microscopy, Electron; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D017550:Spectroscopy, Fourier Transform Infrared; D014057:Tomography, X-Ray Computed; D014283:Triiodobenzoic Acids / Q000737:chemistry*; D014965:X-Rays
D003287:Contrast Media; D005290:Ferric Compounds; D008689:Methacrylates; D014283:Triiodobenzoic Acids; C525207:poly(2-methacryloyloxyethyl(2,3,5-triiodobenzoate)); C104156:2-(2',3',5'-triiodobenzoyl)ethyl methacrylate; C000499:ferric oxide; D007455:Iodine