title: Free radical scavenging phenylethanoid glycosides from Leucas indica Linn.
abstract: A new phenylethanoid glycoside, 2-(3,4-dihydroxyphenyl)-ethyl-O-alpha-L-rhamnopyranosyl-(1 --> 3)-O-alpha-L-rhamnopyranosyl-(1 --> 6)-4-O-E-feruloyl-beta-D-glucopyranoside (3-O-methyl poliu-moside, 1) along with five known phenylethanoid glycosides (2-6) were isolated from the aerial parts of Leucas indica Linn. The structure of compound 1 has been elucidated on the basis of spectral data. Compounds 1-6 exhibited significant antioxidant activity in 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical assay method. These compounds were also found to be moderate inhibitors of xanthine oxidase (XO) enzyme.
authors.affiliation: Chemical Research Division, BCSIR Laboratories, Dhaka 1205, Bangladesh. mostafabcsir@yahoo.com
authors.forename: M
authors.initials: M
authors.lastname: Mostafa
authors.forename: Nilufar
authors.initials: N
authors.lastname: Nahar
authors.forename: M
authors.initials: M
authors.lastname: Mosihuzzaman
authors.forename: Talat
authors.initials: T
authors.lastname: Makhmoor
authors.forename: M Iqbal
authors.initials: MI
authors.lastname: Choudhary
authors.forename: Atta-Ur
authors.initials: AU
authors.lastname: Rahman
mesh_terms: D001459:Bangladesh; D001713:Biphenyl Compounds / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D016166:Free Radical Scavengers / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006834:Hydrazines / Q000378:metabolism; D019686:Lamiaceae / Q000737:chemistry*; D019906:Nuclear Magnetic Resonance, Biomolecular; D009904:Optical Rotation; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D010851:Picrates; D010936:Plant Extracts / Q000737:chemistry; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D014969:Xanthine Oxidase / Q000037:antagonists & inhibitors / Q000378:metabolism
chemical_list: D001713:Biphenyl Compounds; D004791:Enzyme Inhibitors; D016166:Free Radical Scavengers; D006027:Glycosides; D006834:Hydrazines; D010636:Phenols; D010851:Picrates; D010936:Plant Extracts; C004931:1,1-diphenyl-2-picrylhydrazyl; D014969:Xanthine Oxidase