title: Serum adiponectin is increased in advancing liver fibrosis and declines with reduction in fibrosis in chronic hepatitis B.
abstract: OBJECTIVE
  Despite the possible role of adiponectin in the pathogenesis of liver cirrhosis, few data have been collected from patients in different stages of liver fibrosis. We studied the role of adiponectin in 2 chronic hepatitis B (CHB)-patient cohorts.
  
  
  METHODS
  Serum adiponectin was quantified by enzyme-linked immunosorbent assay. One-hundred liver biopsy specimens from CHB patients with different stages of fibrosis and 38 paired liver biopsies from hepatitis B e antigen-positive patients randomized to lamivudine (n=15), pegylated interferon alfa-2a (n=15) or pegylated interferon alfa-2a plus lamivudine (n=8) therapy for 48 weeks were assessed.
  
  
  RESULTS
  Serum adiponectin was detected at levels ranging over fourfold magnitude with advancing fibrosis stage and correlated positively with fibrosis stage [r=0.45, p<0.001]. CHB patients with stage 0-1 fibrosis had higher composition of high molecular weight (HMW) form of adiponectin when compared with CHB patients with liver cirrhosis [mean+/-SEM 51.2+/-2.1% vs. 40.9+/-1.7%, respectively, p=0.001]. After antiviral therapy, patients with fibrosis reduction had marked decline in serum adiponectin level and increase in HMW form of adiponectin [mean+/-SEM 43.5+/-1.2% vs. 37.0+/-3.0%, respectively, p=0.04].
  
  
  CONCLUSIONS
  Serum adiponectin may have a role in fibrosis progression in CHB infection. A marked decline in serum adiponectin after antiviral therapy is associated with fibrosis reduction.
authors.affiliation: Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong SAR, China. ckhui23@gmail.com
authors.forename: Chee-Kin
authors.initials: CK
authors.lastname: Hui
authors.forename: Hai-Ying
authors.initials: HY
authors.lastname: Zhang
authors.forename: Nikki P
authors.initials: NP
authors.lastname: Lee
authors.forename: Weng
authors.initials: W
authors.lastname: Chan
authors.forename: Yui-Hung
authors.initials: YH
authors.lastname: Yueng
authors.forename: Kar-Wai
authors.initials: KW
authors.lastname: Leung
authors.forename: Lei
authors.initials: L
authors.lastname: Lu
authors.forename: Nancy
authors.initials: N
authors.lastname: Leung
authors.forename: Chung-Mau
authors.initials: CM
authors.lastname: Lo
authors.forename: Sheung-Tat
authors.initials: ST
authors.lastname: Fan
authors.forename: John M
authors.initials: JM
authors.lastname: Luk
authors.forename: Aimin
authors.initials: A
authors.lastname: Xu
authors.forename: Karen S
authors.initials: KS
authors.lastname: Lam
authors.forename: Yok-Lam
authors.initials: YL
authors.lastname: Kwong
authors.forename: George K K
authors.initials: GK
authors.lastname: Lau
mesh_terms: D052242:Adiponectin / Q000097:blood* / Q000737:chemistry / Q000235:genetics; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000998:Antiviral Agents / Q000627:therapeutic use; D015331:Cohort Studies; D018450:Disease Progression; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D019694:Hepatitis B, Chronic / Q000150:complications* / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008099:Liver / Q000378:metabolism; D008103:Liver Cirrhosis / Q000097:blood* / Q000378:metabolism / Q000473:pathology* / Q000821:virology; D008297:Male; D008875:Middle Aged; D008970:Molecular Weight; D012333:RNA, Messenger / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012720:Severity of Illness Index
chemical_list: D052242:Adiponectin; D000998:Antiviral Agents; D012333:RNA, Messenger