Triterpenoids from Schisandra rubriflora.
Investigation of an organic extract of Schisandra rubriflora led to the isolation of three new highly oxygenated nortriterpenoids, named rubriflorins A-C (1-3), together with six related known compounds (4-9). Their structures were elucidated by spectroscopic evidence. Compounds 1-3 feature the opening of ring A compared with related known nortriterpenoids isolated from the genus Schisandra and showed anti-HIV-1 activities with EC50 values of 10.0, 16.2, and 81.3 microg/mL, respectively.
Xiao
Wei-Lie
WL
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, People's Republic of China.
Li
Xiao-Li
XL
Wang
Rui-Rui
RR
Yang
Liu-Meng
LM
Li
Li-Mei
LM
Huang
Sheng-Xiong
SX
Pu
Jian-Xin
JX
Zheng
Yong-Tang
YT
Li
Rong-Tao
RT
Sun
Han-Dong
HD
D019380:Anti-HIV Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015497:HIV-1 / Q000187:drug effects*; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D032141:Schisandra / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D019380:Anti-HIV Agents; D004365:Drugs, Chinese Herbal; D014315:Triterpenes; C521652:rubriflorin A; C521653:rubriflorin B; C521654:rubriflorin C