Coats, tethers, Rabs, and SNAREs work together to mediate the intracellular destination of a transport vesicle.
Tethering factors have been shown to interact with Rabs and SNAREs and, more recently, with coat proteins. Coat proteins are required for cargo selection and membrane deformation to bud a transport vesicle from a donor compartment. It was once thought that a vesicle must uncoat before it recognizes its target membrane. However, recent findings have revealed a role for the coat in directing a vesicle to its correct intracellular destination. In this review we will discuss the literature that links coat proteins to vesicle targeting events.
Cai
Huaqing
H
Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06519, USA.
Reinisch
Karin
K
Ferro-Novick
Susan
S
D000818:Animals; D001692:Biological Transport; D020756:Coatomer Protein / Q000378:metabolism*; D006801:Humans; D021122:Protein Subunits / Q000378:metabolism; D050600:SNARE Proteins / Q000378:metabolism*; D022161:Transport Vesicles / Q000378:metabolism*; D020691:rab GTP-Binding Proteins / Q000378:metabolism*
D020756:Coatomer Protein; D021122:Protein Subunits; D050600:SNARE Proteins; D020691:rab GTP-Binding Proteins