title: Replication of hepatitis C virus.
abstract: Exciting progress has recently been made in understanding the replication of hepatitis C virus, a major cause of chronic hepatitis, liver cirrhosis and hepatocellular carcinoma worldwide. The development of complete cell-culture systems should now enable the systematic dissection of the entire viral lifecycle, providing insights into the hitherto difficult-to-study early and late steps. These efforts have already translated into the identification of novel antiviral targets and the development of new therapeutic strategies, some of which are currently undergoing clinical evaluation.
authors.affiliation: Division of Gastroenterology and Hepatology, Centre Hospitalier Universitaire Vaudois, University of Lausanne, CH-1011 Lausanne, Switzerland. darius.moradpour@chuv.ch
authors.forename: Darius
authors.initials: D
authors.lastname: Moradpour
authors.forename: François
authors.initials: F
authors.lastname: Penin
authors.forename: Charles M
authors.initials: CM
authors.lastname: Rice
mesh_terms: D016174:Hepacivirus / Q000235:genetics / Q000502:physiology*; D006526:Hepatitis C / Q000821:virology; D006801:Humans; D014764:Viral Proteins / Q000737:chemistry / Q000502:physiology; D014776:Virus Cultivation / Q000379:methods; D053586:Virus Internalization; D014779:Virus Replication
chemical_list: D014764:Viral Proteins