Vascular endothelial growth factor augments the healing of demineralized bone matrix grafts.
OBJECTIVE
To produce a totally allogeneic graft material that would eliminate the need for harvesting the autogenous bone from patients.


METHODS
Thirty-six (10x5mm) defects were created in the parietal bones of 18 rabbits. Two experimental groups of 12 defects each were grafted with DBM(IM) alone and VEGF+DBM(IM), respectively. The remaining 12 defects were left empty as controls, and sacrificed on days 14, 30 and 60. Two rabbits, with four defects, of each group were sacrificed on day 14, 30 and 60 post grafting. The defects were retrieved for histological evaluation and quantitative analysis.


RESULTS
No bone formed across the defect in the controls. The difference in the amount of new bone formation between experimental groups was significant especially 30 and 60days post grafting (p<0.0001), which were 149% and 100% respectively.


CONCLUSIONS
VEGF+DBM(IM) powder is a promising graft material, and warrants further clinical investigation.
Emad
Bassem
B
University of Hong Kong, Orthodontics, 2/F, Prince Philip Dental Hospital, 34 Hospital Road, Saiyingpun, Hong Kong.
Sherif
El-Mofty
el-M
Basma
Gamal M
GM
Wong
Ricky W K
RW
Bendeus
M
M
Rabie
A Bakr M
AB