title: Antihypertensive effect of an aqueous extract of the calyx of Hibiscus sabdariffa.
abstract: The present study was designed to investigate the efficacy of an aqueous calyx extract of Hibiscus sabdariffa (HS) in two forms of experimental hypertension: salt-induced and L-NAME (N(omega)-L-arginine methyl ester)-induced and in normotensive controls. The blood pressure and heart rate fell dose-dependently in both the hypertensive and normotensive rats after intravenous injection of 1-125 mg/kg of HS, suggesting that HS possesses anti-hypertensive, hypotensive and negative chronotropic effects. The fall in mean arterial pressure was significantly pronounced in the hypertensive rats (salt-induced: 94.4+/-8.6 mm Hg; L-NAME-induced: 136.5+/-10.3 mm Hg) than in the normotensive controls (50.2+/-5.1 mm Hg; P<0.05).
authors.affiliation: Department of Physiology, Usman Danfodio University, Sokoto, Nigeria. mojiminiyi@yahoo.co.uk
authors.forename: F B O
authors.initials: FB
authors.lastname: Mojiminiyi
authors.forename: M
authors.initials: M
authors.lastname: Dikko
authors.forename: B Y
authors.initials: BY
authors.lastname: Muhammad
authors.forename: P D
authors.initials: PD
authors.lastname: Ojobor
authors.forename: O P
authors.initials: OP
authors.lastname: Ajagbonna
authors.forename: R U
authors.initials: RU
authors.lastname: Okolo
authors.forename: U V
authors.initials: UV
authors.lastname: Igbokwe
authors.forename: U E
authors.initials: UE
authors.lastname: Mojiminiyi
authors.forename: M A
authors.initials: MA
authors.lastname: Fagbemi
authors.forename: S O
authors.initials: SO
authors.lastname: Bello
authors.forename: T J
authors.initials: TJ
authors.lastname: Anga
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D035264:Flowers; D006339:Heart Rate / Q000187:drug effects; D031584:Hibiscus; D006973:Hypertension / Q000139:chemically induced / Q000188:drug therapy; D007275:Injections, Intravenous; D019331:NG-Nitroarginine Methyl Ester; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D012965:Sodium Chloride
chemical_list: D000959:Antihypertensive Agents; D010936:Plant Extracts; D012965:Sodium Chloride; D019331:NG-Nitroarginine Methyl Ester