title: A new cytotoxic prenylated chalcone from Sophora flavescens.
abstract: We have isolated a new prenylated chalcone from the roots of Sophora flavescens (Leguminosae). We determined that structure of this compound is 7,9,2',4'-tetrahydroxy-8-isopentenyl-5-methoxychalcone (1) on the basis of spectroscopic analysis (1D and 2D NMR data). Compound 1 exhibited potent cytotoxicity against human acute promyelocytic (HL60), mouse lymphocytic (L1210) and human histiocytic (U937) leukemia cells.
authors.affiliation: Department of Oriental Pharmaceutical Development, Nambu University, Gwangju, Korea.
authors.forename: Jae Hyeok
authors.initials: JH
authors.lastname: Lee
authors.forename: Nam-In
authors.initials: NI
authors.lastname: Baek
authors.forename: Sung-Hoon
authors.initials: SH
authors.lastname: Kim
authors.forename: Hee Wook
authors.initials: HW
authors.lastname: Park
authors.forename: Jae Heon
authors.initials: JH
authors.lastname: Yang
authors.forename: Jeong Joo
authors.initials: JJ
authors.lastname: Lee
authors.forename: Seong Jin
authors.initials: SJ
authors.lastname: Kim
authors.forename: Seung il
authors.initials: Si
authors.lastname: Jeong
authors.forename: Chan-Ho
authors.initials: CH
authors.lastname: Oh
authors.forename: Kyu-Hee
authors.initials: KH
authors.lastname: Lee
authors.forename: Dae Keun
authors.initials: DK
authors.lastname: Kim
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D047188:Chalcones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D017368:Protein Prenylation; D029909:Sophora / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D047188:Chalcones