Myocardial angiogenesis: its absence makes the growing heart founder.
Angiogenesis is essential for normal and neoplastic tissue growth. In a recent issue of Nature, Komuro and colleagues (Sano et al., 2007) describe how p53 expression in hypertrophying heart muscle impairs HIF-1-mediated neovascularization and contributes to functional decompensation of pressure-overload cardiac hypertrophy.
Dorn
Gerald W
GW
Center for Molecular Cardiovascular Research, University of Cincinnati, Cincinnati, OH 45267-0839, USA. dorngw@ucmail.uc.edu
D006332:Cardiomegaly / Q000378:metabolism*; D005786:Gene Expression Regulation / Q000502:physiology; D006321:Heart / Q000502:physiology*; D006801:Humans; D051793:Hypoxia-Inducible Factor 1 / Q000378:metabolism*; D008954:Models, Biological; D018919:Neovascularization, Physiologic / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
D051793:Hypoxia-Inducible Factor 1; D016159:Tumor Suppressor Protein p53