Experience-dependent rescaling of entorhinal grids.
The firing pattern of entorhinal 'grid cells' is thought to provide an intrinsic metric for space. We report a strong experience-dependent environmental influence: the spatial scales of the grids (which are aligned and have fixed relative sizes within each animal) vary parametrically with changes to a familiar environment's size and shape. Thus grid scale reflects an interaction between intrinsic, path-integrative calculation of location and learned associations to the external environment.
Barry
Caswell
C
Institute of Cognitive Neuroscience, University College London, 17 Queen Square, London WC1N 3AR, UK.
Hayman
Robin
R
Burgess
Neil
N
Jeffery
Kathryn J
KJ
D000200:Action Potentials / Q000502:physiology; D000818:Animals; D001522:Behavior, Animal; D001931:Brain Mapping; D018728:Entorhinal Cortex / Q000166:cytology*; D008297:Male; D008568:Memory / Q000502:physiology*; D008959:Models, Neurological; D009474:Neurons / Q000502:physiology*; D009949:Orientation; D010775:Photic Stimulation; D051381:Rats; D013028:Space Perception / Q000502:physiology*