The effect of mode of delivery on placental chorionic plate vascular reactivity.
OBJECTIVE
To determine whether delivery mode influences placental chorionic plate arterial and venous vascular reactivity.


METHODS
Normal term placentas were obtained after vaginal delivery or cesarean section. Chorionic plate arterial and venous function was assessed by wire myography.


RESULTS
Sodium nitroprusside-induced arterial relaxation increased post cesarean section at 20% oxygen. Decreased U46619-induced venous contraction was observed in vaginal deliveries at 7% oxygen. Sodium nitroprusside-induced relaxation increased in vaginal delivery at 20% oxygen.


CONCLUSIONS
Delivery mode does not alter chorionic plate arterial vascular reactivity under physiological conditions, however venous reactivity was modified, a factor for consideration when interpreting functional experimental data.
Mills
Tracey A
TA
Division of Human Development, The University of Manchester, Manchester, UK. tracey.mills@manchester.ac.uk
Baker
Philip N
PN
Wareing
Mark
M
D019796:15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid / Q000494:pharmacology; D000328:Adult; D000704:Analysis of Variance; D001158:Arteries / Q000187:drug effects / Q000502:physiology; D002823:Chorion / Q000098:blood supply*; D036861:Delivery, Obstetric; D004305:Dose-Response Relationship, Drug; D004730:Endothelium, Vascular / Q000187:drug effects; D005260:Female; D006801:Humans; D009213:Myography; D009599:Nitroprusside / Q000494:pharmacology; D010100:Oxygen / Q000097:blood; D010920:Placenta / Q000098:blood supply*; D021041:Placental Circulation / Q000187:drug effects; D011247:Pregnancy; D012016:Reference Values; D014661:Vasoconstriction / Q000187:drug effects; D014662:Vasoconstrictor Agents / Q000494:pharmacology; D014664:Vasodilation / Q000187:drug effects; D014665:Vasodilator Agents / Q000494:pharmacology; D014680:Veins / Q000187:drug effects / Q000502:physiology
D014662:Vasoconstrictor Agents; D014665:Vasodilator Agents; D009599:Nitroprusside; D019796:15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; D010100:Oxygen