Inhibitory effect of palatinose on glucose absorption in everted rat gut.
We previously reported that the increase in blood glucose was more suppressed when palatinose was taken with sucrose or glucose than when either of these sugars was taken alone. In the present study, we examined whether or not palatinose suppresses glucose absorption using everted intestinal sacs from rats. Glucose absorption in the everted rat intestinal sac was measured with 0, 1, 2.5 or 5 mM of palatinose added to 20 mM glucose. The measurement was repeated five times for each palatinose level to calculate a mean value. The result showed glucose absorption to be reduced as the palatinose level increased. It was significantly reduced when 5 mM palatinose was added as compared with no palatinose addition (p<0.05). These results suggest that palatinose suppresses glucose absorption.
Kashimura
Jun
J
Research Laboratory, Mitsui Sugar Co., Ltd., Honson 1-2-14, Chigasaki, Kanagawa 253-0042, Japan. jun.kashimura@mitsui-sugar.co.jp
Nagai
Yukie
Y
D000704:Analysis of Variance; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D007408:Intestinal Absorption / Q000187:drug effects*; D007534:Isomaltose / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D023421:Models, Animal; D051381:Rats; D017208:Rats, Wistar
D001786:Blood Glucose; D007534:Isomaltose; C008189:isomaltulose