Inferring biological networks with output kernel trees.
BACKGROUND
Elucidating biological networks between proteins appears nowadays as one of the most important challenges in systems biology. Computational approaches to this problem are important to complement high-throughput technologies and to help biologists in designing new experiments. In this work, we focus on the completion of a biological network from various sources of experimental data.


RESULTS
We propose a new machine learning approach for the supervised inference of biological networks, which is based on a kernelization of the output space of regression trees. It inherits several features of tree-based algorithms such as interpretability, robustness to irrelevant variables, and input scalability. We applied this method to the inference of two kinds of networks in the yeast S. cerevisiae: a protein-protein interaction network and an enzyme network. In both cases, we obtained results competitive with existing approaches. We also show that our method provides relevant insights on input data regarding their potential relationship with the existence of interactions. Furthermore, we confirm the biological validity of our predictions in the context of an analysis of gene expression data.


CONCLUSIONS
Output kernel tree based methods provide an efficient tool for the inference of biological networks from experimental data. Their simplicity and interpretability should make them of great value for biologists.
Geurts
Pierre
P
IBISC FRE CNRS 2873 & Epigenomics project, GENOPOLE, Evry, France. p.geurts@ulg.ac.be
Touleimat
Nizar
N
Dutreix
Marie
M
d'Alché-Buc
Florence
F
D000465:Algorithms; D001185:Artificial Intelligence; D003198:Computer Simulation; D005786:Gene Expression Regulation / Q000502:physiology*; D008954:Models, Biological; D010363:Pattern Recognition, Automated / Q000379:methods; D020543:Proteome / Q000378:metabolism*; D012044:Regression Analysis; D015398:Signal Transduction / Q000502:physiology*; D049490:Systems Biology / Q000379:methods; D013997:Time Factors
D020543:Proteome