Spectra and DNA-binding affinities of Copper(II), Nickel(II) complexes with a novel glycine Schiff base derived from chromone.
New [CuL.(H(2)O)(3)]NO(3).H(2)O and [NiL.H(2)O]NO(3).2H(2)O complexes with Schiff base (LNa) derived from 6-hydroxy-3-carbaldehyde chromone (CDC) and glycine are reported. Two complexes have been characterized by elemental analysis, IR data, TG/DTA and molar conductivity. The binding of these two complexes to calf thymus DNA (CT-DNA) has been investigated, respectively, with UV-vis spectroscopy, fluorescence spectroscopy and viscosity measurements. The experiment results indicate that the two complexes may bind to CT-DNA through an intercalative mode and [CuL.(H(2)O)(3)]NO(3).H(2)O intercalates into DNA more deeply than [NiL.H(2)O]NO(3).2H(2)O. Their intrinsic binding constants (K) with DNA are 6.08 x 10(5) and 2.76 x 10(5)M(-1).
Qin
Dong-Dong
DD
College of Chemistry and Chemical Engineering and State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, PR China.
Yang
Zheng-Yin
ZY
Wang
Bao-Dui
BD
D000818:Animals; D002417:Cattle; D002867:Chromones / Q000378:metabolism*; D003300:Copper / Q000378:metabolism*; D004247:DNA / Q000378:metabolism*; D004583:Electrons; D005998:Glycine / Q000378:metabolism*; D008024:Ligands; D009532:Nickel / Q000378:metabolism*; D012545:Schiff Bases / Q000378:metabolism*; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013696:Temperature
D002867:Chromones; D008024:Ligands; D012545:Schiff Bases; D003300:Copper; D009532:Nickel; D004247:DNA; C427203:calf thymus DNA; D005998:Glycine