Two ellagic acid glycosides from Gleditsia sinensis Lam. with antifungal activity on Magnaporthe grisea.
Two ellagic acid glycosides were isolated by bioassay-guided fractionation from the antimicrobial ethyl acetate fraction of the ethanol extract from Gleditsia sinensis spines, and identified as 3-O-methylellagic acid-4'-(5''-acetyl)-alpha-L-arabinofuranoside (1) and 3-O-methylellagic acid-4'-O-alpha-L-rhamnopyranoside (2). Both compounds were isolated from this plant species for the first time, and 1 is a new compound. The two compounds showed significant antifungal activity against the spore germination of rice blast fungus Magnaporthe grisea, with an IC(50) value of 13.56 microg mL(-1) for 1 and 16.14 microg mL(-1) for 2.
Zhou
Ligang
L
College of Agronomy and Biotechnology, China Agricultural University, Beijing 100094, China.
Li
Duan
D
Jiang
Weibo
W
Qin
Zhizhong
Z
Zhao
Shuang
S
Qiu
Minghua
M
Wu
Jianyong
J
D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002681:China; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004610:Ellagic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D031501:Gleditsia / Q000737:chemistry*; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D020082:Magnaporthe / Q000187:drug effects* / Q000254:growth & development; D009682:Magnetic Resonance Spectroscopy; D021241:Spectrometry, Mass, Electrospray Ionization; D017550:Spectroscopy, Fourier Transform Infrared
D000935:Antifungal Agents; D004365:Drugs, Chinese Herbal; D006027:Glycosides; D004610:Ellagic Acid