title: [Histoenzymatic study of the liver and submandibular gland of rats exposed to sodium fluoride in drinking water].
abstract: OBJECTIVE
  Universal use of fluorine compounds in dentistry, as well as industrial and civilization-related exposures may produce undesirable effects of fluorine action. The effects of fluoride ions depend on the dose and exposure time. Some may be positive, e.g. in caries prevention, while others are harmful when optimal prophylactic or therapeutic doses have been surpassed. The literature is replete with reports on interactions of fluoride ions with the activity of many enzymes and indirectly with cellular metabolism.
  
  
  METHODS
  The paper presents the results of a histoenzymatic study of the liver and submandibular gland of young rats exposed to NaF administered in drinking water. The intensity of staining for lactate dehydrogenase, succinate dehydrogenase, acid and alkaline phosphatase was evaluated.
  
  
  RESULTS
  The reaction to succinate dehydrogenase in the submandibular gland and lactate dehydrogenase in hepatocytes was attenuated, while the reaction to acid phosphatase was enhanced in the liver when rats were exposed to 32.0 mg NaF/dm(3) of drinking water.
authors.affiliation: Zaklad Stomatologii Spolecznej i Profilaktyki Akademii Medycznej w Białymstoku ul. Akademicka 3, 15-089 Białystok
authors.forename: Ewa
authors.initials: E
authors.lastname: Dabrowska
authors.forename: Maria
authors.initials: M
authors.lastname: Balunowska
authors.forename: Rafał
authors.initials: R
authors.lastname: Letko
mesh_terms: D000284:Administration, Oral; D000367:Age Factors; D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D005457:Fluoridation; D006651:Histocytochemistry; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000201:enzymology* / Q000648:ultrastructure*; D018811:Maternal Exposure; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D012969:Sodium Fluoride / Q000008:administration & dosage / Q000633:toxicity*; D013363:Submandibular Gland / Q000187:drug effects / Q000201:enzymology* / Q000648:ultrastructure*; D013385:Succinate Dehydrogenase / Q000378:metabolism; D036401:Toxicity Tests, Chronic
chemical_list: D012969:Sodium Fluoride; D007770:L-Lactate Dehydrogenase; D013385:Succinate Dehydrogenase; D000469:Alkaline Phosphatase