Ulcer protective effect of Terminalia arjuna on gastric mucosal defensive mechanism in experimental rats.
The methanol extract of the bark of Terminalia arjuna (Combretaceae) (TAE) showed marked antiulcer and ulcer healing activity against 80% ethanol (ETH), diclofenac sodium (DIC) and dexamethasone (DEX) induced ulcer models dose dependently at doses of 100, 400 and 200 mg/kg body weight respectively. Pre-, post and co-administration of TAE offered 100% protection to the gastric mucosa against ETH, DIC and DEX induced ulcers as observed from the ulcer score. Gastric mucosal analysis of DEX induced rats were associated with changes in the levels of protein, protein bound carbohydrate complexes, lipid peroxides (LPO), glutathione (GSH) and activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) compared with control rats. Co-administration with TAE in DEX rats (DEX + TAE) favorably altered the levels of LPO, GSH and also the activities of SOD and CAT in gastric mucosa, whereas the activities of GPx remained unaltered in all groups. In DEX + TAE rats, the levels of protein and protein bound carbohydrate complexes were increased when compared with DEX rats. The results indicate that the gastroprotective effect of TAE is probably related to its ability to maintain the membrane integrity by its antilipid peroxidative activity that protects the gastric mucosa against oxidative damage and its ability to strengthen the mucosal barrier, the first line of defense against exogenous and endogenous ulcerogenic agents.
Devi
R S
RS
Department of Biochemistry, University of Madras, Guindy Campus, Chennai-600 025, Tamil Nadu, India.
Narayan
Shoba
S
Vani
G
G
Srinivasan
P
P
Mohan
K Vijai
KV
Sabitha
K E
KE
Devi
C S Shyamala
CS
D000818:Animals; D003907:Dexamethasone / Q000633:toxicity; D004008:Diclofenac / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000633:toxicity; D005753:Gastric Mucosa / Q000187:drug effects* / Q000473:pathology*; D005765:Gastrointestinal Agents / Q000737:chemistry / Q000494:pharmacology; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D011899:Ranitidine / Q000627:therapeutic use; D051381:Rats; D013276:Stomach Ulcer / Q000517:prevention & control*; D029766:Terminalia / Q000737:chemistry*
D005765:Gastrointestinal Agents; D010936:Plant Extracts; D004008:Diclofenac; D000431:Ethanol; D003907:Dexamethasone; D011899:Ranitidine