New pyrazolic compounds as cytotoxic agents.
The evaluation of the in vitro cytotoxic properties of two pyrazole compounds: 1-(4-nitrophényl)-3,5-diméthylpyrazole (1) and 1,1'-di(4-nitrophényl)-5,5'-diisopropyl-3,3'-bipyrazole (2) was investigated against Hep cell line (Human laryngeal carcinoma). These two compounds showed an important cytotoxic activity on the Hep cell line, with IC(50): 8.25 microg mL(-1) for the compound 1; IC(50): 10.20 microg mL(-1) for the compound 2 while the IC(50) for adriamycine used as positive control was 3.62 microg mL(-1).
Bouabdallah
Ibrahim
I
Laboratory of Organic Chemistry, Macromolecular and Natural Products, Faculty of Sciences, University Mohammed Ier, 60 000 Oujda, Morocco.
M'Barek
Lahcen Ait
LA
Zyad
Abdelmajid
A
Ramdani
Abdelkrim
A
Zidane
Ismail
I
Melhaoui
Ahmed
A
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D003603:Cytotoxins / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005562:Formazans / Q000737:chemistry; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013055:Spectrophotometry, Infrared; D013778:Tetrazolium Salts / Q000737:chemistry
D000970:Antineoplastic Agents; D003603:Cytotoxins; D005562:Formazans; D011720:Pyrazoles; D013778:Tetrazolium Salts; C079782:MTT formazan