title: Assessment of myocardial perfusion for detection of coronary artery stenoses by steady-state, free-precession magnetic resonance first-pass imaging.
abstract: OBJECTIVE
  To evaluate the diagnostic impact of magnetic resonance imaging (MRI) first-pass perfusion using steady-state, free-precession (SSFP) sequences with parallel imaging (SENSE) for detection of coronary stenoses.
  
  
  METHODS
  Prospective observational study.
  
  
  METHODS
  University hospital, cardiac MRI and catheterisation laboratories.
  
  
  METHODS
  228 patients were examined with coronary angiography and MRI (1.5 T Intera CV). A three-slice, short-axis SSFP perfusion scan with a saturation prepulse was performed during infusion of adenosine and at rest followed by myocardial scar (late enhancement) imaging. Gadolinium-DTPA was given at 0.1 mmol/kg body weight. Perfusion images were visually assessed. Analysis for myocardial hypoperfusion was done according to patient group and according to vessel.
  
  
  RESULTS
  Sensitivity, specificity and accuracy of MRI first-pass perfusion for detection of a coronary artery stenosis (>50% luminal narrowing) in the total patient group were 93.0%, 85.7%, 91.2% and for a significant lesion (>70% luminal narrowing) 96.1%, 72.0%, 88.2%, respectively. Based on 536 coronary artery territories without myocardial scar, the sensitivity of MRI perfusion analysis for detection of a significant lesion was for the left anterior descending artery 91.4%, for the circumflex artery 81.6% and for the right coronary artery 65.1% (p<0.001).
  
  
  CONCLUSIONS
  MRI first-pass perfusion analysis using an SSFP sequence with three myocardial slices was a highly accurate diagnostic method for detection of coronary artery stenoses. This MRI technique can be included in daily practice and has the potential to guide the indication for invasive coronary angiography.
authors.affiliation: Department of Internal Medicine II, University of Ulm, Robert-Koch-Strasse-8, 89081 Ulm, Germany.
authors.forename: Nico
authors.initials: N
authors.lastname: Merkle
authors.forename: Jochen
authors.initials: J
authors.lastname: Wöhrle
authors.forename: Olaf
authors.initials: O
authors.lastname: Grebe
authors.forename: Thorsten
authors.initials: T
authors.lastname: Nusser
authors.forename: Markus
authors.initials: M
authors.lastname: Kunze
authors.forename: Hans A
authors.initials: HA
authors.lastname: Kestler
authors.forename: Matthias
authors.initials: M
authors.lastname: Kochs
authors.forename: Vinzenz
authors.initials: V
authors.lastname: Hombach
mesh_terms: D000241:Adenosine; D000368:Aged; D001794:Blood Pressure; D017023:Coronary Angiography; D023921:Coronary Stenosis / Q000175:diagnosis* / Q000503:physiopathology; D005260:Female; D006339:Heart Rate; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012680:Sensitivity and Specificity
chemical_list: D000241:Adenosine