title: The role of the anaesthetist in the management of the pre-eclamptic patient.
abstract: OBJECTIVE
  Recent literature on the anaesthetist's role in the management of the patient with severe pre-eclampsia is reviewed, with particular emphasis on the role of regional anaesthesia.
  
  
  RESULTS
  Laboratory findings in pre-eclamptic women include increased levels of markers of oxidative stress and circulating tyrosine kinase 1, and inflammatory activation of leucocytes. Magnesium sulphate is the most effective agent for seizure prophylaxis. The optimal pharmacological agents for acute control of blood pressure remain controversial. The benefits of epidural analgesia in labour are well established. Single-shot spinal anaesthesia for caesarean section is safe in the absence of contraindications. Successful use of combined spinal-epidural anaesthesia has been described. Most studies on maternal haemodynamics have employed heart rate and blood pressure data as surrogate measures of cardiac output. Noninvasive cardiac output studies provide further insight into the haemodynamic response during neuraxial techniques for caesarean section.
  
  
  CONCLUSIONS
  The value of regional anaesthesia cannot be over-emphasized. Recent research into spinal anaesthesia for caesarean section suggests a lower susceptibility to hypotension and probably less impairment of cardiac output than in healthy parturients. Noninvasive cardiac output measurement may also have advantages in critical care management.
authors.affiliation: Department of Anaesthesia, University of Cape Town and New Groote Schuur Hospital, Cape Town, South Africa. dyer@cormack.uct.ac.za
authors.forename: Robert A
authors.initials: RA
authors.lastname: Dyer
authors.forename: Jenna L
authors.initials: JL
authors.lastname: Piercy
authors.forename: Anthony R
authors.initials: AR
authors.lastname: Reed
mesh_terms: D000328:Adult; D000765:Anesthesia, Conduction; D000768:Anesthesia, General; D000773:Anesthesia, Obstetrical; D000959:Antihypertensive Agents / Q000627:therapeutic use; D003422:Critical Care; D005260:Female; D006801:Humans; D011225:Pre-Eclampsia / Q000503:physiopathology / Q000628:therapy*; D011247:Pregnancy; D012640:Seizures / Q000209:etiology / Q000517:prevention & control
chemical_list: D000959:Antihypertensive Agents