Isolation and structure of platencin: a FabH and FabF dual inhibitor with potent broad-spectrum antibiotic activity.
Jayasuriya
Hiranthi
H
Merck Research Laboratories, P. O. Box 2000, Rahway, New Jersey 07065, USA. Hiranthi_jayasuriya@merck.com
Herath
Kithsiri B
KB
Zhang
Chaowei
C
Zink
Deborah L
DL
Basilio
Angela
A
Genilloud
Olga
O
Diez
Maria Teresa
MT
Vicente
Francisca
F
Gonzalez
Ignacio
I
Salazar
Oscar
O
Pelaez
Fernando
F
Cummings
Richard
R
Ha
Sookhee
S
Wang
Jun
J
Singh
Sheo B
SB
D015099:3-Oxoacyl-(Acyl-Carrier-Protein) Synthase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D000627:Aminophenols / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D011083:Polycyclic Compounds / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000201:enzymology
D000627:Aminophenols; D000900:Anti-Bacterial Agents; D004791:Enzyme Inhibitors; D011083:Polycyclic Compounds; D015099:3-Oxoacyl-(Acyl-Carrier-Protein) Synthase; C520340:platencin