[Role of cholinergic mechanisms of the ventrolateral preoptico-anterior hypothalamic area in regulation of sleep and wakefulness states in pigeons].
Maintenance of wakefulness is established to accomplish muscarinic (M-) cholinergic receptor activation in the ventrolateral preoptic area of the hypothalamus. The "muscarinic" wakefulness is characterized by enhancement of electroencephalogram (EEG) power spectra in the 0.75-12 Hz band and by increase in brain temperature. Activation of nicotinic (N-) cholinergic receptors of the area produces an increase in the duration of slow wave sleep, EEG power spectra reduction in the 0.75-7 Hz band, a decrease in brain temperature. And its hyperactivation leads to wakefulness, during its episodes the brain temperature decreases. During M- and N-cholinergic receptor blockade, the sleep-wakefulness and thermoregulation changes opposite to their activation were found. It is suggested that M- and N-cholinergic receptors of the ventrolateral preoptic area in pigeons participate in the sleep-wakefulness regulation and this effect is related to influence of this area on GABA-ergic system.
Komarova
T G
TG
Ekimova
I V
IV
Pastukhov
Iu F
IuF
D000818:Animals; D007025:Anterior Hypothalamic Nucleus / Q000502:physiology*; D001831:Body Temperature; D001833:Body Temperature Regulation / Q000187:drug effects / Q000502:physiology*; D018679:Cholinergic Agonists / Q000494:pharmacology; D010856:Columbidae / Q000502:physiology*; D011978:Receptors, Nicotinic / Q000378:metabolism; D012890:Sleep / Q000187:drug effects / Q000502:physiology*; D014851:Wakefulness / Q000187:drug effects / Q000502:physiology*
D018679:Cholinergic Agonists; D011978:Receptors, Nicotinic