TRP channels and pain.
Since the molecular identification of the capsaicin receptor, now known as TRPV1, transient receptor potential (TRP) channels have occupied an important place in the understanding of sensory nerve function in the context of pain. Several TRP channels exhibit sensitivity to substances previously known to cause pain or pain-like sensations; these include cinnamaldehyde, menthol, gingerol, and icillin. Many TRP channels also exhibit significant sensitivity to increases or decreases in temperature. Some TRP channels are sensitized in vitro by the activation of other receptors such that these channels may be activated by processes, such as inflammation that result in pain. TRP channels are suggested to be involved in processes as diverse as sensory neuron activation events, neurotransmitter release and action in the spinal cord, and release of inflammatory mediators. These functions strongly suggest that specific and selective inhibition of TRP channel activity will be of use in alleviating pain.
Cortright
Daniel N
DN
Neurogen Corporation, 35 N.E. Industrial Road, Branford, CT 06405, USA. dcortright@nrgn.com
Krause
James E
JE
Broom
Daniel C
DC
D000818:Animals; D001833:Body Temperature Regulation / Q000502:physiology; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D008954:Models, Biological; D009619:Nociceptors / Q000502:physiology; D010146:Pain / Q000209:etiology / Q000503:physiopathology*; D010743:Phospholipids / Q000378:metabolism; D013116:Spinal Cord / Q000502:physiology; D013314:Stress, Mechanical; D050051:Transient Receptor Potential Channels / Q000502:physiology*
D010743:Phospholipids; D050051:Transient Receptor Potential Channels