Beta-endorphins as possible markers for therapeutic drug monitoring.
This study was performed in order to investigate possible role of brain beta-endorphins as markers of antidepressive drugs therapy monitoring. Experiment was done using amitriptyline and trazodone as antidepressants. For quantification of brain beta-endorphins we used RIA technique. Our results showed significant decrease of brain beta-endorphins concentration in drug-pretreated animals, vs. those in of control group treated with 0,95% NaCl. The lower values were obtained in trazodone pre-treated animals. This study shows that use of psychoactive drugs have influence on brain beta-endorphins concentration. beta-endorphins could be of great importance, used as markers for evaluation of patient treatment.
Jadrić
Radivoj
R
Institute for Physiology and Biochemistry, Faculty of Medicine, University of Sarajevo, Cekalusa 90, 71000 Sarajevo, Bosnia and Herzegovina.
Kiseljaković
Emina
E
Hasić
Sabaheta
S
Winterhalter-Jadrić
Mira
M
D000639:Amitriptyline / Q000008:administration & dosage*; D000818:Animals; D000928:Antidepressive Agents / Q000008:administration & dosage*; D015415:Biomarkers / Q000378:metabolism; D001921:Brain / Q000378:metabolism*; D004334:Drug Administration Schedule; D016903:Drug Monitoring / Q000379:methods*; D051381:Rats; D017208:Rats, Wistar; D014196:Trazodone / Q000008:administration & dosage*; D001615:beta-Endorphin / Q000378:metabolism*
D000928:Antidepressive Agents; D015415:Biomarkers; D000639:Amitriptyline; D001615:beta-Endorphin; D014196:Trazodone