title: Development of a drug delivery device: using the femtosecond laser to modify cochlear implant electrodes.
abstract: Animal experiments suggest that pharmacological intervention could possibly enhance cochlear implant performance. One of the key aspects is therefore a drug delivery device for the human inner ear. The objective of this study was to investigate the possibility of using the femtosecond laser for modifying a cochlear implant electrode for the purpose of drug delivery to the cochlea. Using silicone sheets, the best parameters for creating defined channels at calculated diameters were investigated using a femtosecond laser. The results were transferred to a cochlear implant electrode array (Nucleus Contour). The capability of delivering substances through the drilled openings was tested in vitro. By variation of the output of the laser, spot distance, repetition rate, number of cycles and introducing several focus planes, it was possible to drill holes with nearly vertical walls in the silicone sheets. Transferring these data to the cochlear implant electrode resulted in prototypes for drug delivery with various openings along the array. The use of the femtosecond laser allows rapid modification and adaptation of designs to experimental prototypes of cochlear implant electrodes for the purpose of drug delivery to the inner ear.
authors.affiliation: Department of Otolaryngology, Medical University of Hannover, Germany. Stoever.Timo@MH-Hannover.de
authors.forename: T
authors.initials: T
authors.lastname: Stöver
authors.forename: G
authors.initials: G
authors.lastname: Paasche
authors.forename: T
authors.initials: T
authors.lastname: Lenarz
authors.forename: T
authors.initials: T
authors.lastname: Ripken
authors.forename: P
authors.initials: P
authors.lastname: Breitenfeld
authors.forename: H
authors.initials: H
authors.lastname: Lubatschowski
authors.forename: T
authors.initials: T
authors.lastname: Fabian
mesh_terms: D003051:Cochlea / Q000187:drug effects*; D003054:Cochlear Implants; D016503:Drug Delivery Systems / Q000295:instrumentation*; D004567:Electrodes, Implanted; D005240:Feasibility Studies; D006801:Humans; D066298:In Vitro Techniques; D007834:Lasers