title: FarR, a putative regulator of amino acid metabolism in Corynebacterium glutamicum.
abstract: With the publication of the Corynebacterium glutamicum genome sequence, a global characterization of genes controlled by functionally uncharacterized transcriptional regulators became possible. We used DNA microarrays in combination with gel retardation experiments to study gene regulation by FarR, a HutC/FarR-type regulator of the GntR family. Based on our results, FarR seems to be involved in the regulation of amino acid biosynthesis in C. glutamicum. Especially, transcript levels of the arg cluster and the gdh gene are influenced by deletion of farR.
authors.affiliation: Lehrstuhl für Mikrobiologie, Friedrich-Alexander-Universität Erlangen-Nürnberg, Staudtstr. 5, 91058, Erlangen, Germany.
authors.forename: Eva
authors.initials: E
authors.lastname: Hänssler
authors.forename: Tim
authors.initials: T
authors.lastname: Müller
authors.forename: Nadja
authors.initials: N
authors.lastname: Jessberger
authors.forename: Anja
authors.initials: A
authors.lastname: Völzke
authors.forename: Jens
authors.initials: J
authors.lastname: Plassmeier
authors.forename: Jörn
authors.initials: J
authors.lastname: Kalinowski
authors.forename: Reinhard
authors.initials: R
authors.lastname: Krämer
authors.forename: Andreas
authors.initials: A
authors.lastname: Burkovski
mesh_terms: D000596:Amino Acids / Q000378:metabolism*; D001120:Arginine / Q000378:metabolism; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D001483:Base Sequence; D001665:Binding Sites / Q000235:genetics; D001709:Biotechnology; D048230:Corynebacterium glutamicum / Q000235:genetics / Q000378:metabolism*; D017931:DNA Primers / Q000235:genetics; D004269:DNA, Bacterial / Q000235:genetics / Q000378:metabolism; D015964:Gene Expression Regulation, Bacterial; D005798:Genes, Bacterial; D005810:Multigene Family; D020411:Oligonucleotide Array Sequence Analysis; D011401:Promoter Regions, Genetic
chemical_list: D000596:Amino Acids; D001426:Bacterial Proteins; D017931:DNA Primers; D004269:DNA, Bacterial; D001120:Arginine