title: Bioactivity of beer and its influence on human metabolism.
abstract: Extracted total phenols, flavanols and flavonoids were measured in beer samples and their quality as antioxidants was measured by two modified antioxidant methods: the 2,2'-azinobis (3-ethylbenzothiazoline-6-sulfonate) radical cation (ABTS * +) and the beta-carotene-linoleate model system (beta-carotene). It was found that the antioxidant potential of beer was well correlated with flavanols and flavonoids and was slightly lower with total polyphenols (R2 values from 0.8203 to 0.9393). Forty-two male non drinkers, hypercholesterolaemic volunteers ages 43-71 after coronary bypass surgery, were randomly divided into experimental (EG) and control (CG) groups, each of 21 participants. The antiatherosclerotic diet of the EG group was supplemented for 30 consecutive days with 330 ml beer per day. Could short-term beer consumption affect not only the risk factors of coronary atherosclerosis, but also the markers of this process: plasma albumin and its antioxidant activity? For this goal, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, plasma albumin and fibrinogen, and the antioxidant activity were determined. After the trial a significant improvement in the plasma lipid levels, and an increase in the plasma antioxidant and anticoagulant activities in patients of the EG group was registered. A parallel increase in the plasma albumin concentration and its antioxidant activity was observed. In conclusion, short-term beer consumption on the basis of the bioactivity of the beverage positively affects plasma lipid levels, plasma antioxidant and anticoagulant activities. The increase in the plasma albumin concentration and its antioxidant activity could be the markers of atherosclerosis status.
authors.affiliation: Department of Medicinal Chemistry and Natural Products, The Hebrew University-Hadassah Medical School, Jerusalem, Israel. gorin@cc.huji.ac.il
authors.forename: Shela
authors.initials: S
authors.lastname: Gorinstein
authors.forename: Abraham
authors.initials: A
authors.lastname: Caspi
authors.forename: Imanuel
authors.initials: I
authors.lastname: Libman
authors.forename: Hanna
authors.initials: H
authors.lastname: Leontowicz
authors.forename: Maria
authors.initials: M
authors.lastname: Leontowicz
authors.forename: Zev
authors.initials: Z
authors.lastname: Tashma
authors.forename: Elena
authors.initials: E
authors.lastname: Katrich
authors.forename: Zenon
authors.initials: Z
authors.lastname: Jastrzebski
authors.forename: Simon
authors.initials: S
authors.lastname: Trakhtenberg
mesh_terms: D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000032:analysis / Q000494:pharmacology*; D050197:Atherosclerosis / Q000517:prevention & control; D001515:Beer / Q000032:analysis*; D001777:Blood Coagulation / Q000187:drug effects; D001026:Coronary Artery Bypass; D005419:Flavonoids / Q000032:analysis; D044948:Flavonols / Q000032:analysis; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D010636:Phenols / Q000032:analysis; D059808:Polyphenols; D011184:Postoperative Period; D012709:Serum Albumin / Q000378:metabolism
chemical_list: D000975:Antioxidants; D005419:Flavonoids; D044948:Flavonols; D008055:Lipids; D010636:Phenols; D059808:Polyphenols; D012709:Serum Albumin