Rapidly progressive Guillain-Barré syndrome following Escherichia coli infection.
Guillain-Barré Syndrome (GBS) is a prototype of post-infectious autoimmune disease. A 76-year-old woman was treated for a renal abscess and developed muscle weakness in all four extremities, 18 days after the onset of infection. She was diagnosed with GBS on the basis of acute flaccid paralysis, hyporeflexia, nerve conduction studies (reduced amplitude of compound muscle action potentials), and high titers of IgG antibodies to GM1 and GalNAc-GD1a. GBS rarely occurs after sepsis and this case represents the first report of rapidly progressive GBS following Escherichia coli urosepsis.
Kono
Yuriko
Y
General Internal Medicine, Teine Keijinkai Hospital, Sapporo, Japan. yuri@mui.biglobe.ne.jp <yuri@mui.biglobe.ne.jp>
Nishitarumizu
Kazutaka
K
Higashi
Takuya
T
Funakoshi
Kei
K
Odaka
Masaaki
M
D000038:Abscess / Q000382:microbiology; D000368:Aged; D001323:Autoantibodies / Q000097:blood; D018450:Disease Progression; D004927:Escherichia coli Infections / Q000150:complications*; D005260:Female; D005677:G(M1) Ganglioside / Q000276:immunology; D005732:Gangliosides / Q000276:immunology; D020275:Guillain-Barre Syndrome / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007163:Immunosorbent Techniques; D007167:Immunotherapy / Q000379:methods; D007674:Kidney Diseases / Q000382:microbiology; D009431:Neural Conduction; D010264:Paraplegia / Q000209:etiology; D012021:Reflex, Abnormal; D013997:Time Factors
D001323:Autoantibodies; D005732:Gangliosides; D007074:Immunoglobulin G; D005677:G(M1) Ganglioside; C055253:IV(4)-galactosyl-N-acetylganglioside GD1a