FarR, a putative regulator of amino acid metabolism in Corynebacterium glutamicum.
With the publication of the Corynebacterium glutamicum genome sequence, a global characterization of genes controlled by functionally uncharacterized transcriptional regulators became possible. We used DNA microarrays in combination with gel retardation experiments to study gene regulation by FarR, a HutC/FarR-type regulator of the GntR family. Based on our results, FarR seems to be involved in the regulation of amino acid biosynthesis in C. glutamicum. Especially, transcript levels of the arg cluster and the gdh gene are influenced by deletion of farR.
Hänssler
Eva
E
Lehrstuhl für Mikrobiologie, Friedrich-Alexander-Universität Erlangen-Nürnberg, Staudtstr. 5, 91058, Erlangen, Germany.
Müller
Tim
T
Jessberger
Nadja
N
Völzke
Anja
A
Plassmeier
Jens
J
Kalinowski
Jörn
J
Krämer
Reinhard
R
Burkovski
Andreas
A
D000596:Amino Acids / Q000378:metabolism*; D001120:Arginine / Q000378:metabolism; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D001483:Base Sequence; D001665:Binding Sites / Q000235:genetics; D001709:Biotechnology; D048230:Corynebacterium glutamicum / Q000235:genetics / Q000378:metabolism*; D017931:DNA Primers / Q000235:genetics; D004269:DNA, Bacterial / Q000235:genetics / Q000378:metabolism; D015964:Gene Expression Regulation, Bacterial; D005798:Genes, Bacterial; D005810:Multigene Family; D020411:Oligonucleotide Array Sequence Analysis; D011401:Promoter Regions, Genetic
D000596:Amino Acids; D001426:Bacterial Proteins; D017931:DNA Primers; D004269:DNA, Bacterial; D001120:Arginine