Interfering with interferon receptor sorting and trafficking: impact on signaling.
Interferons (IFNs) and their receptors (IFN-Rs) play fundamental roles in a multitude of biological functions. Many articles and reviews emphasize that the JAK/STAT machinery is obligatory for relay of the information transmitted by IFNs after binding to their cognate receptors at the plasma membrane. In contrast, very few studies have addressed the endocytosis and the intracellular trafficking of IFN-Rs, the immediate step following IFN binding. However, recent findings have shed light on the importance of IFN-R sorting and trafficking in the control of IFN signaling. Thus, IFN-Rs can be included in the growing family of signaling receptors for which regulation of biological activity critically involves endocytosis and trafficking.
Claudinon
Julie
J
Laboratoire Trafic et Signalisation, UMR144 Curie/CNRS, Institut Curie, 75248 Paris Cedex 05, France.
Monier
Marie-Noëlle
MN
Lamaze
Christophe
C
D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D002966:Clathrin / Q000378:metabolism; D004705:Endocytosis; D011992:Endosomes / Q000378:metabolism; D006801:Humans; D007372:Interferons / Q000378:metabolism; D053613:Janus Kinase 1 / Q000378:metabolism; D008055:Lipids / Q000737:chemistry; D021962:Membrane Microdomains; D008954:Models, Biological; D017471:Receptors, Interferon / Q000378:metabolism*; D050794:STAT1 Transcription Factor / Q000378:metabolism; D015398:Signal Transduction
D002966:Clathrin; D008055:Lipids; D017471:Receptors, Interferon; D050794:STAT1 Transcription Factor; D007372:Interferons; D053613:Janus Kinase 1