title: Trends in population-based cancer survival in Germany: to what extent does progress reach older patients?
abstract: BACKGROUND
  The ageing of populations makes outcome monitoring among elderly cancer patients particularly important.
  
  
  METHODS
  Using data from the population-based Cancer Registry of Saarland, we examined age-specific trends in 5-year relative survival from 1979 to 2003 for patients with 15 common cancers in Germany. Model-based period analysis was applied to estimate 5-year relative survival for four age groups (15-54, 55-64, 65-74, 75+) in the periods 1979-1983, 1984-1988, 1989-1993, 1994-1998, and 1999-2003.
  
  
  RESULTS
  Overall, 5-year relative survival improved steadily from 42.2% in 1979-1983 to 56.7% in 1999-2003. From the youngest to the oldest age group, 5-year relative survival increased by 14.5, 12.1, 12.5, and 8.4 percent units, respectively, after adjusting for changes in the spectrum of cancer sites, and survival significantly improved for 10, 12, 11, and 5 cancer sites, respectively. The age gradient particularly increased for cancer sites with major progress in chemotherapeutic treatment regimens, such as ovarian cancer, non-Hodgkin's lymphoma and leukemia.
  
  
  CONCLUSIONS
  Relative survival of cancer patients increased considerably for many forms of cancer in Germany from 1979 to 2003. Increases were much less pronounced among elderly patients, leading to an increasing age gradient in prognosis.
authors.affiliation: Division for Clinical Epidemiology and Ageing Research, German Cancer Research Center, Heidelberg, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Gondos
authors.forename: B
authors.initials: B
authors.lastname: Holleczek
authors.forename: V
authors.initials: V
authors.lastname: Arndt
authors.forename: C
authors.initials: C
authors.lastname: Stegmaier
authors.forename: H
authors.initials: H
authors.lastname: Ziegler
authors.forename: H
authors.initials: H
authors.lastname: Brenner
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D005260:Female; D005858:Germany / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000401:mortality*; D011379:Prognosis; D012042:Registries; D016019:Survival Analysis; D015996:Survival Rate