Hepatic function and non-invasive hepatosplanchnic monitoring in patients with abdominal hypertension.
A better understanding of intra-abdominal hypertension with relation to the liver is vital to the management of all forms of liver pathophysiology. Supporting good hepatic function within the critically ill patient is important not only in maintaining synthetic function, but also in avoiding the multi-organ complications of liver dysfunction. The resulting reduction in hepato-splanchnic blood flow (HSBF) observed with increasing intra-abdominal pressure has been clearly documented and seen to be exaggerated in animals with established liver disease. Unfortunately the tools required to measure this, remain difficult to apply routinely in the clinical setting and as such goal directed therapy to specifically improve the hepatosplanchnic circulation remains elusive. Given the documented effects of lAP on HSBF and the relatively high incidence of intra-abdominal hypertension and the abdominal compartment syndrome within "liver patients" as a whole, close attention to IAP and timely correction by appropriate medical or surgical means would appear to be essential.
Cresswell
A B
AB
Institute of Liver Studies, Division of Transplantation and Cell Based Therapy, Kings College London School of Medicine, Kings College Hospital, London, UK.
Wendon
J A
JA
D000005:Abdomen / Q000503:physiopathology*; D006499:Hepatic Artery / Q000503:physiopathology*; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D008099:Liver / Q000098:blood supply* / Q000503:physiopathology*; D005791:Patient Care / Q000379:methods*; D013152:Splanchnic Circulation / Q000502:physiology*