Sex determination: controlling the master.
Sex is determined in Drosophila by the activity of the Sex-lethal master regulator. Activity of Sex-lethal is initiated early in females by chromosome-counting transcription factors, then reinforced by signaling through the Janus kinase pathway.
Harrison
Douglas A
DA
Biology Department, University of Kentucky, Lexington, Kentucky 40506, USA. DougH@email.uky.edu
D017398:Alternative Splicing / Q000502:physiology; D000818:Animals; D004330:Drosophila / Q000502:physiology*; D029721:Drosophila Proteins / Q000378:metabolism*; D005260:Female; D005786:Gene Expression Regulation / Q000502:physiology*; D053612:Janus Kinases / Q000378:metabolism; D019849:Sex Determination Processes; D015398:Signal Transduction / Q000502:physiology*; D014157:Transcription Factors / Q000378:metabolism
D029721:Drosophila Proteins; C122121:Sin protein, Drosophila; D014157:Transcription Factors; D053612:Janus Kinases