p53 and NF-kappaB crosstalk: IKKalpha tips the balance.
Crosstalk between the NF-kappaB and p53 transcription factors can play a pivotal role in determining the cellular response to stress; in a recent issue of Molecular Cell, Huang et al. (2007) show that IkappaB kinase alpha (IKKalpha) can determine which pathway is dominant.
Tergaonkar
Vinay
V
Institute of Molecular and Cell Biology, Proteos 61, Singapore. vinayt@imcb.a-star.edu.sg
Perkins
Neil D
ND
D017209:Apoptosis; D050882:CREB-Binding Protein / Q000378:metabolism; D006801:Humans; D051550:I-kappa B Kinase / Q000378:metabolism*; D016328:NF-kappa B / Q000378:metabolism*; D010766:Phosphorylation; D011485:Protein Binding; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
D016328:NF-kappa B; C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53; D050882:CREB-Binding Protein; C494363:CREBBP protein, human; C496559:CHUK protein, human; D051550:I-kappa B Kinase