Simultaneous recording of neuronal signals and functional NMR imaging.
We recently directly examined the relationship between blood-oxygen-level-dependent (BOLD) functional magnetic resonance imaging (fMRI) signals and neural activity by simultaneously acquiring electrophysiological and fMRI data from monkeys in a 4.7-T vertical scanner (Logothetis NK, Pauls J, Augath MA, Trinath T, Oeltermann A. Neurophysiological investigation of the basis of the fMRI signal. Nature 2001;412:150-157). Acquisition of electrical signals in the microvolt range required extensive development of new recording hardware, including electrodes, microdrives, signal conditioning and interference compensation devices. Here, we provide a detailed description of the interference compensation system that can be used to record field and action potentials intracortically within a high-field scanner.
Oeltermann
Axel
A
Max-Planck Institute for Biological Cybernetics, Department of Physiology of Cognitive Processes, Spemannstrasse 38, 72076 Tübingen, Germany. axel.oeltermann@tuebingen.mpg.de
Augath
Mark A
MA
Logothetis
Nikos K
NK
D000362:Agar; D000818:Animals; D004562:Electrocardiography / Q000379:methods; D004566:Electrodes; D004594:Electrophysiology; D004867:Equipment Design; D008251:Macaca; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008670:Metals / Q000737:chemistry; D015233:Models, Statistical; D009474:Neurons / Q000378:metabolism*; D010100:Oxygen / Q000378:metabolism; D011846:Radio Waves; D013997:Time Factors
D008670:Metals; D000362:Agar; D010100:Oxygen