Should we inhibit angiotensin-converting enzymes in acute heart failure?
Acute heart failure (HF) is characterized by the rapid onset or progression of symptoms and signs secondary to abnormal cardiac function, and remains a common disease associated with high morbidity and mortality rates. Angiotensin-converting enzyme inhibitors (ACEi) are an effective pharmacological option in the treatment of chronic HF, but their effect in acute HF is less well known. This review attempts to summarize the current understanding of acute HF and the pharmacological effects of ACEi in the treatment of acute HF.
Lamond
Nathan W D
NW
Dalhousie University, Halifax, NS, Canada.
Howlett
Jonathan G
JG
D000208:Acute Disease; D000286:Administration, Sublingual; D000465:Algorithms; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D002216:Captopril / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D006333:Heart Failure / Q000188:drug therapy*; D006801:Humans; D045283:Natriuretic Agents / Q000627:therapeutic use; D020097:Natriuretic Peptide, Brain / Q000627:therapeutic use; D017410:Practice Guidelines as Topic; D011654:Pulmonary Edema / Q000188:drug therapy; D016896:Treatment Outcome; D014665:Vasodilator Agents / Q000627:therapeutic use
D000806:Angiotensin-Converting Enzyme Inhibitors; D045283:Natriuretic Agents; D014665:Vasodilator Agents; D020097:Natriuretic Peptide, Brain; D002216:Captopril