title: Local recurrence and occult neoplastic cells in the extranodal fat of dissected lymph nodes in patients with curatively resected primary colorectal cancer.
abstract: This study was designed to examine the relationship between occult neoplastic cells (ONCs) inside and outside harvested lymph nodes (intranodal/extranodal ONCs) and local recurrence in 30 patients who underwent curative resection of primary colorectal cancer. Among 10 patients with colon cancer (Dukes' A=1, Dukes' B=6 and Dukes' C=3), intranodal ONCs were positive in 1 patient (10.0%) and negative in 9 patients (90.0%), while extranodal ONCs were negative in all 10 patients (100.0%). There were no significant differences between the detection of intranodal or extranodal ONCs. Among 20 patients with rectal cancer (Dukes' A=4, Dukes' B=2 and Dukes' C=14), intranodal ONCs were positive in 5 (25.0%) and negative in 15 (75.0%), while extranodal ONCs were positive in 3 (15.0%) and negative in 17 (85.0%). There were no significant differences between the detection of intranodal or extranodal ONCs. These results suggest that patients with rectal cancer and extranodal ONCs should be followed-up carefully as a high-risk group for pelvic local recurrence. However, the prevalence of extranodal and intranodal ONCs was almost similar.
authors.affiliation: Department of Surgery, Tokai University Hachioji Hospital, Hachioji, Tokyo 192-0032, Japan. mukai.masaya@hachioji-hosp.tokai.ac.jp
authors.forename: Masaya
authors.initials: M
authors.lastname: Mukai
authors.forename: Masato
authors.initials: M
authors.lastname: Nakamura
authors.forename: Kyoko
authors.initials: K
authors.lastname: Kishima
authors.forename: Hiromi
authors.initials: H
authors.lastname: Ninomiya
authors.forename: Nozomi
authors.initials: N
authors.lastname: Nomura
authors.forename: Hisayoshi
authors.initials: H
authors.lastname: Sato
authors.forename: Nobuaki
authors.initials: N
authors.lastname: Kato
authors.forename: Tomohisa
authors.initials: T
authors.lastname: Machida
authors.forename: Hisao
authors.initials: H
authors.lastname: Nakasaki
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Makuuchi
mesh_terms: D000273:Adipose Tissue / Q000473:pathology*; D015179:Colorectal Neoplasms / Q000473:pathology* / Q000601:surgery*; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology* / Q000601:surgery; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology*; D012306:Risk