Coenzyme Q, oxidative stress and aging.
Coenzyme Q (CoQ) has three well-characterized functions in mitochondria, namely (i) transfer of reducing equivalents in the electron transport chain, (ii) generation of superoxide anion radical, O2*-, and (iii) quenching of free radicals. The main purpose of this review is to discuss the effects of CoQ10 intake for relatively prolonged periods on mitochondrial respiratory capacity, indicators of oxidative stress, and life span of animals, in context of the broader issue of whether or not the overall progression of the aging process can be modified by CoQ10 administration. Comparative studies on different mammalian species have indicated that the rate of mitochondrial superoxide anion radical generation is directly correlated with mitochondrial CoQ9 content and inversely related to amounts of CoQ10, particularly the CoQ10 bound to mitochondrial membrane proteins. Contrary to the historical view, dietary supplementation of mice and rats with CoQ10 has been demonstrated to augment the endogenous CoQ content (CoQ9 + CoQ10) in mitochondria and homogenates of various tissues, albeit to varying extent. Ingestion of CoQ10 results in the elevation of endogenous CoQ9, the predominant homologue in mice and rats. In our studies, there was no indication of a discernable effect of CoQ10 intake reflecting enhancement of mitochondrial respiratory activity, antioxidant capacity and pro-oxidant potentiation or prolongation of life span. The possibility that CoQ10 intake affects certain other biological functions by as yet unelucidated mechanisms cannot be ruled out as CoQ has been shown to broadly alter gene expression in mice.
Sohal
Rajindar S
RS
Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, 1985 Zonal Avenue, PSC 608, Los Angeles, CA 90089-9121, USA. sohal@usc.edu
Forster
Michael J
MJ
D000367:Age Factors; D000375:Aging; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D005609:Free Radicals; D006801:Humans; D008928:Mitochondria / Q000378:metabolism; D051336:Mitochondrial Membranes / Q000378:metabolism; D008954:Models, Biological; D018384:Oxidative Stress; D013045:Species Specificity; D013481:Superoxides / Q000378:metabolism; D014451:Ubiquinone / Q000378:metabolism / Q000502:physiology*; D014810:Vitamin E / Q000378:metabolism; D024502:alpha-Tocopherol / Q000378:metabolism
D000975:Antioxidants; D005609:Free Radicals; D013481:Superoxides; D014451:Ubiquinone; D014810:Vitamin E; D024502:alpha-Tocopherol