Phylogenetic groups and virulence factors of Escherichia coli strains causing pyelonephritis in children with and without urinary tract abnormalities.
Escherichia coli isolates causing acute pyelonephritis in 93 children (25% with urinary tract abnormalities) were tested for nine virulence factors (papC, papGII, papGIII, sfa/foc, hlyC, cnf1, iucC, fyuA and iroN) and their phylogenetic groups were determined. Isolates lacking papGII were more frequent among patients with urinary tract abnormalities (58% vs. 10%, p 0.0003), as were non-virulent phylogenetic group A isolates (25% vs. 5%, p 0.043). Pyelonephritis caused by less virulent E. coli strains was more frequent among patients with significant urinary tract abnormalities. Further studies are required to determine whether screening for E. coli virulence factors may help to identify children warranting anatomical investigations.
Houdouin
V
V
Laboratoire d'Etudes de Génétique Bactérienne dans les Infections de l'Enfant (EA3105), Université Denis Diderot-Paris 7, Paris, France.
Bonacorsi
S
S
Mahjoub-Messai
F
F
Mariani-Kurkdjian
P
P
Bidet
P
P
Sebag
G
G
Loirat
C
C
Bourrillon
A
A
Bingen
E
E
D000208:Acute Disease; D018830:Adhesins, Escherichia coli / Q000235:genetics / Q000378:metabolism; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004926:Escherichia coli / Q000235:genetics / Q000378:metabolism / Q000472:pathogenicity*; D004927:Escherichia coli Infections / Q000382:microbiology; D029968:Escherichia coli Proteins / Q000235:genetics; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D010802:Phylogeny; D011704:Pyelonephritis / Q000382:microbiology*; D014551:Urinary Tract / Q000002:abnormalities*; D037521:Virulence Factors / Q000235:genetics* / Q000378:metabolism
D018830:Adhesins, Escherichia coli; D029968:Escherichia coli Proteins; C519334:PapGII protein, E coli; D037521:Virulence Factors