title: Comparative antimalarial activities of six pairs of 1,2,4,5-tetraoxanes (peroxide dimers) and 1,2,4,5,7,8-hexaoxonanes (peroxide trimers).
abstract: Six tetraoxanes had 50% inhibitory concentrations in the range of 10 to 100 ng/ml against Plasmodium falciparum, whereas the corresponding hexaoxonanes had minimal antimalarial activity. The lack of iron-mediated reactivity of the hexaoxonanes may explain their low activity compared to the tetraoxanes, the latter of which are able to undergo iron(II)-mediated activation.
authors.affiliation: College of Pharmacy, University of Nebraska Medical Center, 986025 Nebraska Medical Center, Omaha, NE 68198-6025, USA.
authors.forename: Yuxiang
authors.initials: Y
authors.lastname: Dong
authors.forename: Darren
authors.initials: D
authors.lastname: Creek
authors.forename: Jacques
authors.initials: J
authors.lastname: Chollet
authors.forename: Hugues
authors.initials: H
authors.lastname: Matile
authors.forename: Susan A
authors.initials: SA
authors.lastname: Charman
authors.forename: Sergio
authors.initials: S
authors.lastname: Wittlin
authors.forename: James K
authors.initials: JK
authors.lastname: Wood
authors.forename: Jonathan L
authors.initials: JL
authors.lastname: Vennerstrom
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000494:pharmacology*; D019281:Dimerization; D004351:Drug Resistance; D020128:Inhibitory Concentration 50; D007501:Iron / Q000378:metabolism; D051379:Mice; D008958:Models, Molecular; D021261:Parasitic Sensitivity Tests; D010545:Peroxides / Q000737:chemistry / Q000494:pharmacology*; D010962:Plasmodium berghei / Q000187:drug effects*; D010963:Plasmodium falciparum / Q000187:drug effects*; D013329:Structure-Activity Relationship; D045568:Tetraoxanes / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000962:Antimalarials; D010545:Peroxides; D045568:Tetraoxanes; D007501:Iron