Intestinal endometriosis complicated by ileal perforation after initiation of gonadotropin-releasing hormone agonist therapy.
OBJECTIVE
To report a rare complication of GnRH agonist therapy for intestinal endometriosis.


METHODS
Case report.


METHODS
University hospital.


METHODS
A 45-year-old nulliparous Japanese woman with catamenial digestive symptoms.


METHODS
GnRH agonist therapy.


METHODS
Acute abdomenal crisis with free air in the abdominal X-ray.


RESULTS
An emergency laparotomy showed both an ileal constriction and perforation. An ileocecal enterectomy with an end-to-end anastomosis was performed. A pathological examination of the ileum revealed ileal endometriosis.


CONCLUSIONS
Flare-up of intestinal endometriosis induced by GnRH agonist has the potential to lead to intestinal perforation. Careful diagnosis and treatment are necessary for cyclic and periodic gastrointestinal manifestation.
Saito
Sayaka
S
Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Murakami
Takashi
T
Suzuki
Kichiya
K
Terada
Yukihiro
Y
Fukushima
Kouhei
K
Moriya
Takuya
T
D000006:Abdomen, Acute / Q000139:chemically induced*; D004715:Endometriosis / Q000139:chemically induced / Q000150:complications*; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists*; D006801:Humans; D007077:Ileal Diseases / Q000209:etiology*; D007416:Intestinal Perforation / Q000209:etiology*; D016729:Leuprolide / Q000009:adverse effects*; D008875:Middle Aged
D007987:Gonadotropin-Releasing Hormone; D016729:Leuprolide