Supercritical carbon dioxide: putting the fizz into biomaterials.
This paper describes recent progress made in the use of high pressure or supercritical fluids to process polymers into three-dimensional tissue engineering scaffolds. Three current examples are highlighted: foaming of acrylates for use in cartilage tissue engineering; plasticization and encapsulation of bioactive species into biodegradable polyesters for bone tissue engineering; and a novel laser sintering process used to fabricate three-dimensional biodegradable polyester structures from particles prepared via a supercritical route.
Barry
John J A
JJ
Tissue Engineering Group, School of Pharmacy, The University of Nottingham, University Park, Nottingham NG7 2RD, UK.
Silva
Marta M C G
MM
Popov
Vladimir K
VK
Shakesheff
Kevin M
KM
Howdle
Steven M
SM
D001672:Biocompatible Materials / Q000737:chemistry*; D002245:Carbon Dioxide / Q000737:chemistry*; D025924:Chromatography, Supercritical Fluid / Q000379:methods*; D008968:Molecular Conformation; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure*; D011108:Polymers / Q000737:chemistry*; D011312:Pressure
D001672:Biocompatible Materials; D011108:Polymers; D002245:Carbon Dioxide