title: Solid dispersion adsorbates for enhancement of dissolution rates of drugs.
abstract: Amalgamation of solid dispersion and melt adsorption technologies was utilized for enhancing the dissolution rate of poorly soluble drugs. Glibenclamide was employed as a model drug. PEG6000 and Gelucire44/14 were used as hydrophilic carriers for the preparation of solid dispersions, and lactose was utilized as an adsorbent for the preparation of solid dispersion adsorbates. A high dissolution rate of solid dispersion adsorbates was observed when compared to solid dispersions alone and one of the marketed products.
authors.affiliation: Faculty of Pharmaceutical Sciences, M.D. University, Rohtak, India.
authors.lastname: Deepti
authors.forename: Harish
authors.initials: H
authors.lastname: Dureja
authors.forename: A K
authors.initials: AK
authors.lastname: Madan
mesh_terms: D000327:Adsorption; D002626:Chemistry, Pharmaceutical; D004337:Drug Carriers; D005905:Glyburide / Q000737:chemistry; D007004:Hypoglycemic Agents / Q000737:chemistry; D007700:Kinetics; D007785:Lactose / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*; D012995:Solubility; D013499:Surface Properties; D013678:Technology, Pharmaceutical / Q000379:methods; D013696:Temperature
chemical_list: D004337:Drug Carriers; D007004:Hypoglycemic Agents; C104509:gelucire 44-14; D011092:Polyethylene Glycols; D007785:Lactose; D005905:Glyburide