Ectopic ossification of the triceps muscle after application of bone morphogenetic protein-7 to the distal humerus for recalcitrant nonunion: a case report.
We report a case of triceps muscle ectopic ossification and resultant elbow stiffness after application of recombinant human bone morphogenetic protein to a distal humerus nonunion site. We recommend caution when using this product in the upper extremity in regions where there is close approximation of soft tissue to bone and where loss of motion would be problematic.
Wysocki
Robert W
RW
Orthopaedic Surgery, Rush Medical College, Chicago, IL, USA. robert_wysocki@rsh.net
Cohen
Mark S
MS
D000293:Adolescent; D019485:Bone Morphogenetic Proteins / Q000008:administration & dosage / Q000009:adverse effects*; D005593:Fracture Fixation, Internal; D005599:Fractures, Ununited / Q000601:surgery*; D006801:Humans; D006810:Humeral Fractures / Q000601:surgery*; D007085:Ilium / Q000637:transplantation; D008297:Male; D018482:Muscle, Skeletal / Q000000981:diagnostic imaging*; D009999:Ossification, Heterotopic / Q000000981:diagnostic imaging / Q000209:etiology*; D011859:Radiography; D012086:Reoperation; D012907:Smoking / Q000009:adverse effects
D019485:Bone Morphogenetic Proteins; C511401:osteogenic protein 1 putty, recombinant human