title: Risk of metabolic complications in the new PCOS phenotypes based on the Rotterdam criteria.
abstract: OBJECTIVE
  To determine the risk of metabolic complications, primarily metabolic syndrome, in all polycystic ovary syndrome (PCOS) phenotypes compared with control subjects.
  
  
  METHODS
  Retrospective chart review.
  
  
  METHODS
  University practice.
  
  
  METHODS
  Women with PCOS (Rotterdam definition; n = 258) and women without PCOS seen during the same time period for an annual exam used as controls (n = 110).
  
  
  METHODS
  None.
  
  
  METHODS
  Metabolic syndrome.
  
  
  RESULTS
  Three PCOS phenotypes had a significantly higher prevalence of metabolic syndrome compared with the control subjects: oligomenorrhea/oligo-ovulation (O) + hyperandrogenism (H) + polycystic ovaries (P), age-adjusted odds ratio [OR] 6.3 (95% confidence interval 2.1-18.9); O+H, OR 7.8 (2.2-27.5); and H+P, OR 8.2 (2.3-29.3). There was no significant difference in the prevalence of metabolic syndrome between women with O+P and control subjects, even in obese women. The prevalence of insulin resistance and glucose intolerance was not significantly different between POCS phenotypes
  
  
  CONCLUSIONS
  The risk of metabolic syndrome may vary among the four phenotypes of PCOS based on the Rotterdam criteria. This new information may be of relevance in counseling women with PCOS although larger studies may be needed to validate our findings.
authors.affiliation: Department of Obstetrics and Gynecology, University of Iowa, Roy J. and Lucille A. Carver College of Medicine, Iowa City, IA 52242, USA.
authors.forename: Rupal
authors.initials: R
authors.lastname: Shroff
authors.forename: Craig H
authors.initials: CH
authors.lastname: Syrop
authors.forename: William
authors.initials: W
authors.lastname: Davis
authors.forename: Bradley J
authors.initials: BJ
authors.lastname: Van Voorhis
authors.forename: Anuja
authors.initials: A
authors.lastname: Dokras
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D024821:Metabolic Syndrome / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics / Q000378:metabolism; D008875:Middle Aged; D010641:Phenotype; D011085:Polycystic Ovary Syndrome / Q000175:diagnosis* / Q000453:epidemiology / Q000235:genetics / Q000378:metabolism*; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors