Synthesis of terpene and steroid dimers and trimers having cyclobutadienyl-Co and aromatic tethers.
The reaction of natural product derived propargylic alcohols with CpCo(CO)2 produces three new types of natural product hybrids having two or three terpene or steroid fragments. The tether joining the natural product subunits is built during the reaction. Type 1 hybrids have two terpene or steroid moieties joined by a CpCo-cyclobutadiene tether, with the two units disposed in a 1,2-arrangement (9, 14, 22). Type 2 hybrids have a Co-cyclopentadienone tether (10). Type 3 has three units of terpene or steroid joined to a benzene ring (11, 12, 15). An unusual Co-mediated beta-carbon elimination pathway of propargylic alcohols leading to ketones (an unknown process in this chemistry) has been observed.
Sierra
Miguel A
MA
Departamento de Química OrgAnica and Laboratorio de Difracción de Rayos X, Facultad de Química, Universidad Complutense, 28040-Madrid, Spain.
Torres
M Rosario
MR
Torre
María C de la
MC
Alvaro
Elsa
E
D000480:Alkynes / Q000737:chemistry; D003503:Cyclobutanes / Q000737:chemistry*; D019281:Dimerization; D007659:Ketones / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D020005:Propanols / Q000737:chemistry; D013237:Stereoisomerism; D013256:Steroids / Q000138:chemical synthesis* / Q000737:chemistry; D013729:Terpenes / Q000138:chemical synthesis* / Q000737:chemistry
D000480:Alkynes; D003503:Cyclobutanes; D007659:Ketones; D020005:Propanols; D013256:Steroids; D013729:Terpenes; C028255:propargyl alcohol