title: Drosophila female sterile mutation spoonbill interferes with multiple pathways in oogenesis.
abstract: spoonbill is a Drosophila female-sterile mutation, which displays a range of eggshell and egg chamber patterning defects. Previous analysis has shown that the mutation interfered with the function of two major signaling pathways, GRK/EGFR and DPP. In this report, the nature of spoonbill was further investigated to examine whether it was associated with additional pathways in oogenesis. Clonal analysis, presented here, demonstrated that most of the aberrant phenotypes associated with spoonbill were dependent on a mutant germline. Nevertheless, SPOONBILL may function also in the soma to ensure proper polarization and migration of the border-cell-cluster. Further, genetic interaction studies implicated spoonbill in additional unrelated pathways such as the one(s) involved in actin polymerization/depolymerization. Based on the previous data and the results presented here, it is anticipated that spoonbill may encode a multifunctional protein that perhaps coordinately regulated the activity of multiple signaling pathways during oogenesis.
authors.affiliation: Department of Virology and Developmental Genetics, Faculty of Health Sciences and Cancer Research Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel. shiraz@bgu.ac.il
authors.forename: F Shira
authors.initials: FS
authors.lastname: Neuman-Silberberg
mesh_terms: D000818:Animals; D004330:Drosophila / Q000235:genetics / Q000254:growth & development*; D005260:Female; D017344:Genes, Insect; D007247:Infertility, Female / Q000235:genetics*; D009154:Mutation; D009866:Oogenesis / Q000235:genetics*; D010063:Ovum / Q000737:chemistry / Q000378:metabolism* / Q000648:ultrastructure; D015398:Signal Transduction / Q000235:genetics