title: Multi-modal magnetic resonance imaging quantifies atherosclerosis and vascular dysfunction in patients with type 2 diabetes mellitus.
abstract: Vascular magnetic resonance imaging (MRI) is emerging as a powerful research tool. We studied 18 patients with type 2 diabetes mellitus and 20 controls (all with coronary artery disease). MRI measured distensibility, pulse wave velocity (PWV) and atherosclerosis in the aorta, and brachial artery flow-mediated dilatation (FMD). Patients with diabetes showed lower aortic distensibility (2.1 x 10(-3) vs . 3.5 x 10(-3) mmHg-1, p<0.01), faster PWV (8.8 vs ., 6.2 m/s, p<0.01) and impaired FMD (8.5% vs . 13.8%, p<0.05). Diabetes was an independent negative predictor of distensibility. Aortic atherosclerosis was similar in the two groups. There was a negative correlation between aortic distensibility and atherosclerosis in control subjects only, suggesting that other factors such as protein cross-linking may explain lower aortic distensibility in diabetes. MRI provides comprehensive vascular phenotyping in patients with type 2 diabetes and is likely to be useful in studies of disease progression and drug therapy.
authors.affiliation: Department of Cardiovascular Medicine, University of Oxford, Oxford, UK.
authors.forename: Justin M S
authors.initials: JM
authors.lastname: Lee
authors.forename: Cheerag
authors.initials: C
authors.lastname: Shirodaria
authors.forename: Clare E
authors.initials: CE
authors.lastname: Jackson
authors.forename: Matthew D
authors.initials: MD
authors.lastname: Robson
authors.forename: Charalambos
authors.initials: C
authors.lastname: Antoniades
authors.forename: Jane M
authors.initials: JM
authors.lastname: Francis
authors.forename: Frank
authors.initials: F
authors.lastname: Wiesmann
authors.forename: Keith M
authors.initials: KM
authors.lastname: Channon
authors.forename: Stefan
authors.initials: S
authors.lastname: Neubauer
authors.forename: Robin P
authors.initials: RP
authors.lastname: Choudhury
mesh_terms: D000368:Aged; D001158:Arteries / Q000473:pathology / Q000503:physiopathology; D050197:Atherosclerosis / Q000209:etiology / Q000473:pathology* / Q000503:physiopathology; D003324:Coronary Artery Disease / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000503:physiopathology; D003925:Diabetic Angiopathies / Q000209:etiology / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D019028:Magnetic Resonance Imaging, Cine; D008875:Middle Aged