From planta to pharma with glycosylation in the toolbox.
Plant-specific glycosylation has long been a major limitation to the extensive use of plant-made pharmaceuticals in human therapy. Our goal here is to highlight the progress recently made towards humanization of N-glycosylation in plants and to illustrate that plant-typical N- and O-glycosylation progressively emerge as additional advantages for using this promising expression system.
Saint-Jore-Dupas
Claude
C
CNRS UMR 6037, IFRMP 23, GDR 2590, Université de Rouen, Faculté des Sciences Bât. Ext. Biologie, 76821 Mont-Saint-Aignan cedex, France.
Faye
Loïc
L
Gomord
Véronique
V
D006031:Glycosylation; D016695:Glycosyltransferases / Q000378:metabolism*; D004364:Pharmaceutical Preparations / Q000737:chemistry / Q000378:metabolism*; D010944:Plants / Q000737:chemistry / Q000378:metabolism*; D030821:Plants, Genetically Modified / Q000378:metabolism; D011134:Polysaccharides / Q000096:biosynthesis* / Q000737:chemistry / Q000235:genetics / Q000378:metabolism
D004364:Pharmaceutical Preparations; D011134:Polysaccharides; D016695:Glycosyltransferases