Protective effect of ascorbic acid against oxidative stress induced by inorganic arsenic in liver and kidney of rat.
Ascorbic acid treatment in arsenic trioxide treated rats increased arsenic excretion, inhibited lipid peroxidation, improved GSH status, regulated GSSG turnover and also restored glutathione-S-transferases activity in liver and kidney. Suitable mechanisms leading to ascorbic acid protection have been discussed. Upregulation of GSH dependent enzymes was found to be necessary for a protective effect. Protection is finally attributed to higher GSH levels observed in the liver and kidney of ascorbic acid and inorganic arsenic treated rats. It is also concluded that ascorbic acid protection is influenced by gender dependent factors. Arsenic poisoning is a global problem now. Gender differences need to be considered while applying therapeutic measures.
Sohini
Toxicology Laboratory, Department of Zoology, Ch. Charan Singh University, Meerut 250 004, India.
Rana
S V S
SV
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001151:Arsenic / Q000037:antagonists & inhibitors* / Q000633:toxicity; D001205:Ascorbic Acid / Q000494:pharmacology*; D005260:Female; D007668:Kidney / Q000187:drug effects*; D008099:Liver / Q000187:drug effects*; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar
D000975:Antioxidants; D001151:Arsenic; D001205:Ascorbic Acid