Chromosome congression: the kinesin-8-step path to alignment.
During mitosis, chromosomes must become aligned at the equator of the mitotic spindle before segregation. Recent work suggests that a kinesin-8 motor uses a unique combination of activities to regulate this process.
Stumpff
Jason
J
Department of Physiology and Biophysics, University of Washington, Seattle, Washington 98195, USA.
Wordeman
Linda
L
D000705:Anaphase / Q000502:physiology*; D020090:Chromosome Segregation / Q000502:physiology*; D006801:Humans; D016547:Kinesins / Q000378:metabolism*; D018386:Kinetochores / Q000378:metabolism; D008870:Microtubules / Q000378:metabolism; D020409:Molecular Motor Proteins / Q000378:metabolism*
D020409:Molecular Motor Proteins; C502735:KIF18A protein, human; D016547:Kinesins