Benign parathyroid adenoma presenting with unusual parathyroid crisis, anemia and myelofibrosis.
Although the clinical symptoms of patients with benign parathyroid adenoma are usually nonspecific and benign, a malignant presentation of the benign disease may sometimes occur. Here, we report a case of a 58-year-old woman who presented with aggravated sacrum pain, general malaise, and polydipsia. Initial laboratory findings revealed hypercalcemia, normocytic anemia, and impaired renal function. Acute hypercalcemic crisis manifested and primary hyperparathyroidism was diagnosed together with myelofibrosis on account of the result of bone marrow biopsy. Excision of a parathyroid adenoma was performed, and the anemia and bone marker regressed later. These findings suggested that benign parathyroid adenoma may mimic the clinical presentation of parathyroid carcinoma, releasing excess parathyroid hormone and resulting in hyperparathyroid crisis. In addition, primary hyperparathyroidism can be associated with anemia and myelofibrosis.
Huang
Shu-Chuan
SC
Division of Endocrinology and Metabolism, Department of Internal Medicine, Taoyuan Veterans Hospital, Taoyuan, Taiwan.
Wu
Vin-Cent
VC
Chou
Guan
G
Huang
Tzu-Yu
TY
Lin
Shih-Yi
SY
Sheu
Wayne Huey-Herng
WH
D000236:Adenoma / Q000150:complications*; D000740:Anemia / Q000209:etiology*; D005260:Female; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology*; D049950:Hyperparathyroidism, Primary / Q000209:etiology*; D008875:Middle Aged; D010282:Parathyroid Neoplasms / Q000150:complications*; D055728:Primary Myelofibrosis / Q000209:etiology*