title: Refractory seizures associated with an organic aciduria in a dog.
abstract: A 6-month-old, female Cavalier King Charles spaniel exhibited seizures that were difficult to control with standard anticonvulsants over a 12-month period. The diagnosis of an organic aciduria with excessive excretion of hexanoylglycine was determined when the dog was 20 months old. Recurrent and cluster seizures were eventually controlled with the addition of levetiracetam to potassium bromide and phenobarbital.
authors.affiliation: Department of Small Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens, Georgia 30602-7390, USA.
authors.forename: Simon
authors.initials: S
authors.lastname: Platt
authors.forename: Yvonne L
authors.initials: YL
authors.lastname: McGrotty
authors.forename: Carley J
authors.initials: CJ
authors.lastname: Abramson
authors.forename: Cornelis
authors.initials: C
authors.lastname: Jakobs
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000008:administration & dosage*; D001965:Bromides / Q000008:administration & dosage; D002331:Carnitine / Q000031:analogs & derivatives / Q000097:blood; D004283:Dog Diseases / Q000188:drug therapy* / Q000503:physiopathology / Q000652:urine*; D004285:Dogs; D004359:Drug Therapy, Combination; D017809:Fatal Outcome; D005260:Female; D005998:Glycine / Q000031:analogs & derivatives* / Q000652:urine; D000077287:Levetiracetam; D010634:Phenobarbital / Q000008:administration & dosage; D010889:Piracetam / Q000008:administration & dosage / Q000031:analogs & derivatives; D017680:Potassium Compounds / Q000008:administration & dosage; D012640:Seizures / Q000188:drug therapy / Q000662:veterinary*; D016896:Treatment Outcome
chemical_list: D000927:Anticonvulsants; D001965:Bromides; D017680:Potassium Compounds; C116917:acylcarnitine; C024571:N-caproylglycine; D000077287:Levetiracetam; C039004:potassium bromide; D002331:Carnitine; D005998:Glycine; D010634:Phenobarbital; D010889:Piracetam