title: Somatostatin receptor PET imaging with Gallium-68 labeled peptides.
abstract: Imaging somatostatin receptor status with 68Ga labeled peptides has progressed rapidly over the last several years. It has generated great interest, and stimulated further research into the development of DOTA-derivative peptides. It has expanded our knowledge of receptor imaging and enhanced our appreciation of the difference between receptor-based and metabolic imaging, as well as more in-depth evaluation of tumor biology. The availability of the 68Ge/68Ga generator provides an attractive alternative to cyclotron-based positron-emitters, especially if kit-based radiopharmaceutical formulations based upon 68Ga are developed in the future.
authors.affiliation: Department of Nuclear Medicine, Hammersmith Hospital, London, UK.
authors.forename: Z
authors.initials: Z
authors.lastname: Win
authors.forename: A
authors.initials: A
authors.lastname: Al-Nahhas
authors.forename: D
authors.initials: D
authors.lastname: Rubello
authors.forename: M D
authors.initials: MD
authors.lastname: Gross
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism; D005710:Gallium Radioisotopes; D006801:Humans; D007553:Isotope Labeling / Q000379:methods; D009363:Neoplasm Proteins / Q000378:metabolism; D009369:Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism*; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals; D017481:Receptors, Somatostatin / Q000378:metabolism*; D013004:Somatostatin / Q000031:analogs & derivatives*
chemical_list: D014408:Biomarkers, Tumor; D005710:Gallium Radioisotopes; D009363:Neoplasm Proteins; D019275:Radiopharmaceuticals; D017481:Receptors, Somatostatin; D013004:Somatostatin