title: RXR-LXR heterodimer modulators for the potential treatment of dyslipidemia.
abstract: A number of RXR agonists were synthesized and screened in functional assays. The synthesis and the structure-activity relationship (SAR) within the series of compounds will be presented. Some in vivo data in rodent models for dyslipidemia and diabetes will also be presented.
authors.affiliation: Johnson and Johnson Pharmaceutical Research and Development, Cranbury, NJ 08869, USA. blagu@prdus.jnj.com
authors.forename: Bharat
authors.initials: B
authors.lastname: Lagu
authors.forename: Barbara
authors.initials: B
authors.lastname: Pio
authors.forename: Rimma
authors.initials: R
authors.lastname: Lebedev
authors.forename: Maria
authors.initials: M
authors.lastname: Yang
authors.forename: Patricia D
authors.initials: PD
authors.lastname: Pelton
mesh_terms: D000818:Animals; D004268:DNA-Binding Proteins / Q000819:agonists* / Q000378:metabolism; D003920:Diabetes Mellitus / Q000188:drug therapy*; D019281:Dimerization; D004195:Disease Models, Animal; D050171:Dyslipidemias / Q000188:drug therapy*; D007004:Hypoglycemic Agents / Q000138:chemical synthesis / Q000494:pharmacology* / Q000627:therapeutic use; D000071518:Liver X Receptors; D057093:Orphan Nuclear Receptors; D051381:Rats; D017207:Rats, Sprague-Dawley; D018160:Receptors, Cytoplasmic and Nuclear / Q000819:agonists* / Q000378:metabolism; D047488:Retinoid X Receptors / Q000819:agonists* / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D004268:DNA-Binding Proteins; D007004:Hypoglycemic Agents; D000071518:Liver X Receptors; D057093:Orphan Nuclear Receptors; D018160:Receptors, Cytoplasmic and Nuclear; D047488:Retinoid X Receptors