title: [The "tako-tsubo" syndrome: report of two cases].
abstract: The "tako-tsubo" syndrome, initially described by Japanese authors is an apical akinesis of the left ventricule without significant coronary artery disease, with a moderate elevation of troponine I. We report 2 cases of women (with an average age of 68 years). They were refered for suspected acute coronary syndrome including on admission chest pain and ST segment elevation. Cardiac ultrasonography shew an apical akinesis. Coronary angiography didn't show significant coronary lesion. A moderate elevation of troponine was noted but no significant elevation of CPK. The prognosis has been excellent for these 2 patients. We observed a ventricular tachycardia due to QT lengthening in 1 case treated anteriorly by Flecaïn which spontaneously resolved. The first month, the electrocardiogram and cardiac ultrasonography anomalies disappeared totally. The treatment is based on beta-blockers, aspirin, statines, ACE. In the two cases, we didn't find arguments for myocarditis, recanalized thrombosis, coronary spasm, pheochromocytomas, but a risk factor is inboth: emotional stress. Maybe the diagnosis could be easier with the submillimeter cardiac computed tomography.
authors.affiliation: Service de cardiologie, Centre Hospitalier de Vichy, boulevard Deniere, 03209 Vichy, France.
authors.forename: N
authors.initials: N
authors.lastname: Ferrier
authors.forename: G
authors.initials: G
authors.lastname: Bitar
authors.forename: X
authors.initials: X
authors.lastname: Marcaggi
authors.forename: G
authors.initials: G
authors.lastname: Amat
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000368:Aged; D001241:Aspirin / Q000627:therapeutic use; D009202:Cardiomyopathies / Q000175:diagnosis* / Q000188:drug therapy; D004562:Electrocardiography; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis* / Q000188:drug therapy
chemical_list: D000319:Adrenergic beta-Antagonists; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D010975:Platelet Aggregation Inhibitors; D001241:Aspirin