Atypical p-ANCA is not a poor prognostic marker in Postinfectious Glomerulonephritis.
Postinfectious glomerulonephritis (PIGN) most commonly follows streptococcal infection. Antineutrophil cytoplasmic antibodies (ANCA) are characteristically negative in PIGN. We report on five cases who had positive atypical pANCA at presentation. The outcome was typical of other cases of PIGN with complete resolution of the glomerulonephritis in all five patients. Atypical pANCA occurs in a number of inflammatory conditions and antigenic targets may include proteins other than myeloperoxidase or proteinase 3. The presence of atypical p-ANCA does not indicate a poor prognosis.
Waters
Aoife
A
Division of Nephrology, The Hospital for Sick Children, M5G 1X8 Toronto, Canada.
Langlois
Valerie
V
Thorner
Paul
P
Geary
Denis
D
D019268:Antibodies, Antineutrophil Cytoplasmic / Q000032:analysis / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005921:Glomerulonephritis / Q000276:immunology*; D006801:Humans; D007223:Infant; D008297:Male; D011379:Prognosis
D019268:Antibodies, Antineutrophil Cytoplasmic