title: Increased incidence of stent thrombosis in patients with cocaine use.
abstract: BACKGROUND
  Coronary stent thrombosis is a rare occurrence in the era of dual-antiplatelet therapy. It is not known whether patients who use cocaine have a higher risk of thrombosis following coronary stent placement.
  
  
  METHODS
  We studied 247 consecutive patients who underwent coronary stent placement at an inner-city hospital.
  
  
  RESULTS
  Twelve patients (4.9%) were actively using cocaine at the time of PCI. Of these twelve patients, four patients presented with stent thrombosis (33%) at a mean of 51 +/- 40 days (median 45 days), after the index revascularization procedure. Only 2 of the 235 patients without documented cocaine use (0.85%) had stent thrombosis during the same period (P < 0.0001).
  
  
  CONCLUSIONS
  The patients who actively use cocaine have a markedly higher risk of stent thrombosis when compared with patients without a documented history of cocaine use. We discuss various factors that potentially predispose cocaine users to stent thrombosis.
authors.affiliation: Cardiac Catheterization Laboratories, Krannert Institute of Cardiology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.
authors.forename: Gudjon
authors.initials: G
authors.lastname: Karlsson
authors.forename: Jalees
authors.initials: J
authors.lastname: Rehman
authors.forename: Vijay
authors.initials: V
authors.lastname: Kalaria
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Breall
mesh_terms: D000787:Angina Pectoris / Q000209:etiology / Q000517:prevention & control; D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects*; D001241:Aspirin / Q000627:therapeutic use; D000077144:Clopidogrel; D019970:Cocaine-Related Disorders / Q000150:complications*; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000628:therapy*; D003328:Coronary Thrombosis / Q000150:complications / Q000000981:diagnostic imaging / Q000209:etiology* / Q000517:prevention & control; D004359:Drug Therapy, Combination; D005500:Follow-Up Studies; D006786:Hospitals, Urban / Q000706:statistics & numerical data; D006801:Humans; D008875:Middle Aged; D009203:Myocardial Infarction / Q000209:etiology / Q000517:prevention & control; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D012107:Research Design; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D015607:Stents; D013988:Ticlopidine / Q000031:analogs & derivatives / Q000627:therapeutic use; D013997:Time Factors; D016896:Treatment Outcome; D014481:United States
chemical_list: D010975:Platelet Aggregation Inhibitors; D000077144:Clopidogrel; D013988:Ticlopidine; D001241:Aspirin