Regulation of transient receptor potential (TRP) channels by phosphoinositides.
This review summarizes the modulation of transient receptor potential (TRP) channels, by phosphoinositides. TRP channels are characterized by polymodal activation and a surprising complexity of regulation mechanisms. Possibly, most if not all TRP channels are modulated by phosphoinositides. Modulation by phosphatidylinositol 4,5-biphosphate (PIP(2)) has been shown in detail for TRP vanilloid (TRPV) 1, TRPV5, TRP melastatin (TRPM) 4, TRPM5, TRPM7, TRPM8, TRP polycystin 2, and the Drosophila TPR-like (TRPL) channels. This review describes mechanisms of modulation of TRP channels mainly by PIP(2) and discusses some future challenges of this fascinating topic.
Rohacs
Tibor
T
Department of Pharmacology and Physiology, University of Medicine and Dentistry of New Jersey-New Jersey Medical School, Newark, NJ, 07103, USA. tibor.rohacs@umdnj.edu
Nilius
Bernd
B
D000818:Animals; D006801:Humans; D019269:Phosphatidylinositol 4,5-Diphosphate / Q000494:pharmacology; D010716:Phosphatidylinositols / Q000494:pharmacology*; D050051:Transient Receptor Potential Channels / Q000187:drug effects*
D019269:Phosphatidylinositol 4,5-Diphosphate; D010716:Phosphatidylinositols; D050051:Transient Receptor Potential Channels