[Expression of drug resistance and metastasis related gene in adenoid cystic carcinoma and mucoepidermoid carcinoma].
OBJECTIVE
To examine the differential gene expression among adenoid cystic carcinoma ACC-M, low metastasis ACC-2 and low differentiated mucoepidermoid carcinoma MEC-1 with gene array, and detect three important genes with real-time quantitative PCR.


METHODS
Gene array was used to screen the differential genes, then three important genes were selected and detected by real-time quantitative PCR.


RESULTS
The gene contents of MDR-1, MRP-1 and CCD1 were MEC-1 > ACC-M > ACC-2, MEC-1 > ACC-M > ACC-2 and MEC-1 > ACC-M > ACC-2 respectively.


CONCLUSIONS
Drug resistance of MEC-1 is related with high content of MDR-1. High metastasis of ACC-M is concerned with high content of MRP-1 and low content of CCD-1. Low metastasis of ACC-2 has a relationship with low content of MRP1.
Wang
Xiao-feng
XF
Department of Oral and Maxillofacial Surgery, The Second Clinical College, Harbin Medical University, Harbin 150086, China. wdm@hit.edu.cn
Guo
Yang
Y
Jia
Shen-shan
SS
D003528:Carcinoma, Adenoid Cystic / Q000235:genetics*; D018277:Carcinoma, Mucoepidermoid / Q000235:genetics*; D045744:Cell Line, Tumor; D019008:Drug Resistance, Neoplasm / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic; D019450:Genes, MDR; D006801:Humans; D009362:Neoplasm Metastasis / Q000235:genetics*; D020411:Oligonucleotide Array Sequence Analysis; D016133:Polymerase Chain Reaction; D012468:Salivary Gland Neoplasms / Q000235:genetics*