AMPK mediates autophagy during myocardial ischemia in vivo.
We have recently shown that autophagy is induced by ischemia and reperfusion in the mouse heart in vivo. Ischemia stimulates autophagy through an AMP activated protein kinase (AMPK)-dependent mechanism, whereas reperfusion after ischemia stimulates autophagy through a Beclin 1-dependent, but AMPK-independent, mechanism. Autophagy plays distinct roles during ischemia and reperfusion: autophagy may be protective during ischemia, whereas it may be detrimental during reperfusion. We will discuss the role of AMPK in mediating autophagy during myocardial ischemia in vivo.
Takagi
Hiromitsu
H
Cardiovascular Research Institute, Department of Cell Biology and MolecularMedicine, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey 07103, USA.
Matsui
Yutaka
Y
Hirotani
Shinichi
S
Sakoda
Hideyuki
H
Asano
Tomoichiro
T
Sadoshima
Junichi
J
D055372:AMP-Activated Protein Kinases; D000818:Animals; D051017:Apoptosis Regulatory Proteins; D001343:Autophagy / Q000502:physiology*; D000071186:Beclin-1; D002478:Cells, Cultured; D004789:Enzyme Activation; D051379:Mice; D008954:Models, Biological; D009097:Multienzyme Complexes / Q000378:metabolism*; D017202:Myocardial Ischemia / Q000378:metabolism*; D015425:Myocardial Reperfusion; D032383:Myocytes, Cardiac / Q000166:cytology / Q000378:metabolism; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism
D051017:Apoptosis Regulatory Proteins; D000071186:Beclin-1; C115010:Becn1 protein, mouse; D009097:Multienzyme Complexes; D011506:Proteins; D017346:Protein Serine-Threonine Kinases; D055372:AMP-Activated Protein Kinases