title: The radiological manifestations of sickle cell disease.
abstract: Sickle cell disease (SCD) is an inherited abnormality of the beta-globin chain, which causes a spectrum of haemolytic anaemias. Clinical manifestations in SCD include anaemia, jaundice, recurrent vaso-occlusive crises, and infections (particularly by encapsulated bacteria) due to functional asplenia and cerebrovascular accidents. Radiological investigations play a critical role both in the diagnosis and in the primary prevention of the complications of SCD.
authors.affiliation: Department of Radiology, Royal Free Hospital NHS Trust, London, UK. gittamadani@yahoo.com
authors.forename: G
authors.initials: G
authors.lastname: Madani
authors.forename: A M
authors.initials: AM
authors.lastname: Papadopoulou
authors.forename: B
authors.initials: B
authors.lastname: Holloway
authors.forename: A
authors.initials: A
authors.lastname: Robins
authors.forename: J
authors.initials: J
authors.lastname: Davis
authors.forename: D
authors.initials: D
authors.lastname: Murray
mesh_terms: D000755:Anemia, Sickle Cell / Q000150:complications / Q000000981:diagnostic imaging*; D001853:Bone Marrow / Q000098:blood supply / Q000000981:diagnostic imaging; D001921:Brain / Q000000981:diagnostic imaging; D001927:Brain Diseases / Q000150:complications / Q000000981:diagnostic imaging; D006486:Hemosiderosis / Q000150:complications / Q000000981:diagnostic imaging; D006801:Humans; D007238:Infarction / Q000150:complications / Q000000981:diagnostic imaging; D007674:Kidney Diseases / Q000150:complications / Q000000981:diagnostic imaging; D008099:Liver / Q000000981:diagnostic imaging; D008107:Liver Diseases / Q000150:complications / Q000000981:diagnostic imaging; D008168:Lung / Q000000981:diagnostic imaging; D008171:Lung Diseases / Q000150:complications / Q000000981:diagnostic imaging; D010019:Osteomyelitis / Q000150:complications / Q000000981:diagnostic imaging; D011859:Radiography; D013154:Spleen / Q000000981:diagnostic imaging; D013158:Splenic Diseases / Q000150:complications / Q000000981:diagnostic imaging