title: Role of endoscopic surgery in the management of selected malignant epithelial neoplasms of the naso-ethmoidal complex.
abstract: BACKGROUND
  This study reviews the outcome of patients with adenocarcinoma (AC) and squamous cell carcinoma (SCC) of the naso-ethmoidal complex treated by endoscopic surgery.
  
  
  METHODS
  Sixteen patients underwent a purely endoscopic excision of AC (n = 12) or SCC (n = 4) at 2 university hospitals. All patients were prospectively followed by endoscopic and MRI evaluations.
  
  
  RESULTS
  The tumor originated from the ethmoid in 13 cases and the nasal fossa in 3. Lesions were staged as follows: 5 T1, 10 T2, and 1 T3. Adjuvant radiotherapy was delivered in 7 cases. Follow-up (range, 28-70 months; mean, 47.25) was available for all patients. One patient died for brain metastases 28 months after surgery. Another patient required salvage craniofacial resection and radiotherapy for recurrent AC. Five-year disease-specific and disease-free survival rates were 93.3% and 87.0%, respectively.
  
  
  CONCLUSIONS
  In selected T1-T2 lesions of the naso-ethmoidal complex, endoscopic surgery seems to offer a satisfactory alternative to external procedures.
authors.affiliation: Department of Otorhinolaryngology, University of Brescia, Piazza Spedali Civili 1, 25123 Brescia, Italy. pieronicolai@virgilio.it
authors.forename: Piero
authors.initials: P
authors.lastname: Nicolai
authors.forename: Paolo
authors.initials: P
authors.lastname: Castelnuovo
authors.forename: Davide
authors.initials: D
authors.lastname: Lombardi
authors.forename: Paolo
authors.initials: P
authors.lastname: Battaglia
authors.forename: Maurizio
authors.initials: M
authors.lastname: Bignami
authors.forename: Luca
authors.initials: L
authors.lastname: Pianta
authors.forename: Davide
authors.initials: D
authors.lastname: Tomenzoli
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D018572:Disease-Free Survival; D004724:Endoscopy; D005005:Ethmoid Sinus / Q000473:pathology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009669:Nose Neoplasms / Q000473:pathology / Q000628:therapy*; D010255:Paranasal Sinus Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D011446:Prospective Studies; D018714:Radiotherapy, Adjuvant