Metabolic syndrome and gastrointestinal diseases.
Metabolic syndrome is a cluster of metabolic abnormalities consisting essentially of obesity, especially abdominal obesity. Metabolic syndrome has been highlighted as a risk factor for cardiovascular and other chronic diseases. Obesity has been implicated in various gastrointestinal diseases such as gastroesophageal reflux diseases and colorectal cancer. Recently, abdominal obesity has been shown to be more important than obesity as expressed by an elevated body mass index as a causative factor for the development of these diseases. In addition to the mechanical effects of obesity, such as an increase in intra-abdominal pressure from large amounts of adipose tissue, substances that adipose tissues secrete, such as tumor necrosis factor-alpha, interleukin-6, leptin, and insulin-like growth factor-1, have been proposed to be pathogenic links to these diseases. In this review, we discuss the association of metabolic syndrome or the individual components of metabolic syndrome, focusing on obesity and abdominal obesity, with gastrointestinal diseases.
Watanabe
Sumio
S
Department of Gastroenterology, Juntendo University, School of Medicine, 2-1-1 Hongo, Tokyo 113-8421, Japan.
Hojo
Mariko
M
Nagahara
Akihito
A
D000230:Adenocarcinoma / Q000453:epidemiology; D000273:Adipose Tissue / Q000378:metabolism / Q000503:physiopathology; D001471:Barrett Esophagus / Q000453:epidemiology; D015992:Body Mass Index; D015179:Colorectal Neoplasms / Q000453:epidemiology; D015897:Comorbidity; D018450:Disease Progression; D004938:Esophageal Neoplasms / Q000453:epidemiology; D005764:Gastroesophageal Reflux / Q000453:epidemiology / Q000209:etiology / Q000503:physiopathology; D005767:Gastrointestinal Diseases / Q000453:epidemiology*; D006801:Humans; D024821:Metabolic Syndrome / Q000453:epidemiology*; D009765:Obesity / Q000150:complications / Q000453:epidemiology* / Q000503:physiopathology; D012307:Risk Factors