Diffusible signal factor-dependent cell-cell signaling and virulence in the nosocomial pathogen Stenotrophomonas maltophilia.
The genome of Stenotrophomonas maltophilia encodes a cell-cell signaling system that is highly related to the diffusible signal factor (DSF)-dependent system of the phytopathogen Xanthomonas campestris. Here we show that in S. maltophilia, DSF signaling controls factors contributing to the virulence and antibiotic resistance of this important nosocomial pathogen.
Fouhy
Yvonne
Y
BIOMERIT Research Centre, Department of Microbiology, BioSciences Institute, National University of Ireland, Cork, Ireland.
Scanlon
Karl
K
Schouest
Katherine
K
Spillane
Charles
C
Crossman
Lisa
L
Avison
Matthew B
MB
Ryan
Robert P
RP
Dow
J Maxwell
JM
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001426:Bacterial Proteins / Q000235:genetics* / Q000378:metabolism / Q000502:physiology; D003428:Cross Infection / Q000382:microbiology; D024881:Drug Resistance, Bacterial / Q000235:genetics; D015964:Gene Expression Regulation, Bacterial; D005798:Genes, Bacterial; D006801:Humans; D019216:Metals, Heavy / Q000494:pharmacology; D005810:Multigene Family; D009154:Mutation; D015398:Signal Transduction / Q000235:genetics* / Q000502:physiology; D020615:Stenotrophomonas maltophilia / Q000187:drug effects / Q000235:genetics* / Q000472:pathogenicity; D014774:Virulence / Q000235:genetics; D016959:Xanthomonas campestris / Q000235:genetics
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D019216:Metals, Heavy