title: Selective inhibition of porcine endogenous retrovirus replication in human cells by acyclic nucleoside phosphonates.
abstract: Several anti-human immunodeficiency virus type 1 reverse transcriptase inhibitors were evaluated for their antiviral activities against porcine endogenous retrovirus in human cells. Among the test compounds, zidovudine was found to be the most active. The order of potency was zidovudine > phosphonylmethoxyethoxydiaminopyrimidine = phosphonylmethoxypropyldiaminopurine > tenofovir > or = adefovir > stavudine.
authors.affiliation: Frontier Science Research Center, Kagoshima University, Kagoshima 890-8544, Japan.
authors.forename: Minyi
authors.initials: M
authors.lastname: Shi
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
authors.forename: Erik
authors.initials: E
authors.lastname: De Clercq
authors.forename: Sonshin
authors.initials: S
authors.lastname: Takao
authors.forename: Masanori
authors.initials: M
authors.lastname: Baba
mesh_terms: D000225:Adenine / Q000031:analogs & derivatives / Q000494:pharmacology; D000595:Amino Acid Sequence; D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D002384:Catalysis; D002460:Cell Line; D004305:Dose-Response Relationship, Drug; D020077:Endogenous Retroviruses / Q000187:drug effects* / Q000201:enzymology / Q000502:physiology; D015497:HIV-1 / Q000187:drug effects / Q000201:enzymology; D006801:Humans; D007668:Kidney / Q000166:cytology; D008969:Molecular Sequence Data; D063065:Organophosphonates / Q000737:chemistry / Q000494:pharmacology*; D016133:Polymerase Chain Reaction; D017434:Protein Structure, Tertiary; D018894:Reverse Transcriptase Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D018119:Stavudine / Q000494:pharmacology; D013552:Swine; D013556:Swine, Miniature; D000068698:Tenofovir; D014779:Virus Replication / Q000187:drug effects*; D015215:Zidovudine / Q000494:pharmacology
chemical_list: D000998:Antiviral Agents; D063065:Organophosphonates; D018894:Reverse Transcriptase Inhibitors; D015215:Zidovudine; C053001:adefovir; D000068698:Tenofovir; D018119:Stavudine; D000225:Adenine