Hereditary factors in multiple primary malignancies associated with lung cancer.
OBJECTIVE
There are differences between lung cancer alone and multiple primary malignancies associated with lung cancer (MPMLC) in terms of clinical characteristics. However, the importance of these differences has not yet been clarified.


METHODS
Univariate and multivariate analyses were performed on 123 patients with MPMLC and 815 patients with lung cancer alone who underwent operative procedures for lung cancer from August 1982 to March 2004.


RESULTS
Age, number of family with a family history of other malignancies except for smoking-related cancers, and pathological early stage of lung cancer were significantly high in patients with MPMLC based on univariate analyses (P < 0.0001, P < 0.05, and P < 0.05, respectively). Age and family history of malignancy were thus found to be significant factors based on a multivariate analysis.


CONCLUSIONS
MPMLC demonstrated a significant association with advanced age and stronger hereditary factors in comparison with lung cancer alone, indicating the need for different approaches to properly manage and follow up risk patients.
Haraguchi
Shuji
S
Department of Surgery, Nippon Medical School Musashikosugi Hospital, Kawasaki, Kanagawa 211-8533, Japan.
Koizumi
Kiyoshi
K
Hioki
Masafumi
M
Hisayoshi
Takao
T
Hirata
Tomomi
T
Shimizu
Kazuo
K
D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D003110:Colonic Neoplasms / Q000235:genetics; D005260:Female; D006801:Humans; D016015:Logistic Models; D008175:Lung Neoplasms / Q000453:epidemiology / Q000235:genetics / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009378:Neoplasms, Multiple Primary / Q000453:epidemiology / Q000235:genetics*; D012907:Smoking / Q000453:epidemiology; D013274:Stomach Neoplasms / Q000235:genetics