Relationship between the soluble F11 receptor and markers of inflammation in hemodialysis patients.
BACKGROUND
The human F11 receptor (F11R) is an important cell adhesion molecule implicated in inflammatory thrombosis. We hypothesize that serum levels of the soluble released form of F11R (sF11R) are elevated in dialysis patients since these patients have higher cardiovascular disease burdens than the general population. In this study, we examined whether sF11R levels were elevated in hemodialysis (HD) patients and correlated with known inflammatory cytokines.


METHODS
We used new and standard enzyme-linked immunosorbent assay techniques to measure levels of sF11R, as well as high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-10 (IL-10), in a cross section of 52 HD patients and compared these with 15 healthy controls.


RESULTS
The mean age of the patients was 56 +/- 17.3 years; 60% were female, and 36% had diabetes mellitus. Serum levels of sF11R, hs-CRP, TNF-alpha, IL-6, and IL-10 were all significantly higher in patients than in control sera (p < .05). Within the patient group, there was a significant positive correlation between sF11R and TNF-alpha (r = .41, p = .003), IL-10 (r = .32, p = .023), and IL-6 (r = .32, p = .023), whereas hs-CRP showed no significant correlation (r = -.27, p = .052).


CONCLUSIONS
We conclude that the sF11R level is elevated in HD patients and correlates with known markers of cardiovascular disease. sF11R may be a novel cardiovascular risk marker, and longitudinal studies are needed to better assess its relationship with cardiovascular disease morbidity and mortality in this population.
Salifu
Moro O
MO
Department of Medicine, SUNY Downstate Medical Center, Brooklyn, NY 11203, USA. moro@salifu.net
Kolff
Quirine
Q
Murty
Preethi
P
Haria
Dhiren M
DM
Zimpa
Mahamadu
M
Shakeel
Muhammad
M
Lee
Howon
H
Kornecki
Elizabeth
E
Babinska
Anna
A
D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D015815:Cell Adhesion Molecules / Q000097:blood*; D016207:Cytokines / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D016753:Interleukin-10 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D011956:Receptors, Cell Surface / Q000097:blood*; D006435:Renal Dialysis; D051437:Renal Insufficiency / Q000097:blood* / Q000628:therapy; D012307:Risk Factors; D018709:Statistics, Nonparametric; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
D015415:Biomarkers; D015815:Cell Adhesion Molecules; D016207:Cytokines; C407243:F11R protein, human; D015850:Interleukin-6; D011956:Receptors, Cell Surface; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; D002097:C-Reactive Protein