Targeting fat to prevent diabetes.
An emerging view is that obesity causes metabolic problems when adipose tissue fails to meet the increased demands for fat storage. A study in this issue of Cell Metabolism (Waki et al., 2007) has identified harmine as a proadipogenic small molecule that promotes energy expenditure in white adipose tissue and delays the onset of obesity-associated diabetes.
Sethi
Jaswinder K
JK
Department of Clinical Biochemistry, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 2QR, UK. jks30@cam.ac.uk
Vidal-Puig
Antonio J
AJ
D050156:Adipogenesis / Q000187:drug effects*; D000273:Adipose Tissue / Q000378:metabolism*; D000818:Animals; D003920:Diabetes Mellitus / Q000209:etiology / Q000517:prevention & control*; D006247:Harmine / Q000378:metabolism* / Q000494:pharmacology; D006801:Humans; D051379:Mice; D009765:Obesity / Q000150:complications* / Q000378:metabolism; D047495:PPAR gamma / Q000378:metabolism
D047495:PPAR gamma; D006247:Harmine