Heat shock responses for understanding diseases of protein denaturation.
Extracellular stresses induce heat shock response and render cells resistant to lethal stresses. Heat shock response involves induction of heat shock proteins (Hsps). Recently the roles of Hsps in neurodegenerative diseases and cancer are attracting increasing attention and have accelerated the study of heat shock response mechanism. This review focuses on the stress sensing steps, molecules involved in Hsps production, diseases related to Hsp malfunctions, and the potential of proteomics as a tool for understanding the complex signaling pathways relevant to these events.
Kim
Hee-Jung
HJ
The Center for Cell Signaling and Drug Discovery Research, College of Pharmacy and Division of Life and Pharmaceutical Sciences, Ewha Womans University, Seoul 120-750, Korea.
Hwang
Na Rae
NR
Lee
Kong-Joo
KJ
D006360:Heat-Shock Proteins / Q000502:physiology*; D006358:Hot Temperature; D009369:Neoplasms / Q000378:metabolism*; D019636:Neurodegenerative Diseases / Q000378:metabolism*; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism*; D011489:Protein Denaturation; D017510:Protein Folding; D040901:Proteomics; D017382:Reactive Oxygen Species / Q000378:metabolism; D015398:Signal Transduction
D006360:Heat-Shock Proteins; D017382:Reactive Oxygen Species; D046988:Proteasome Endopeptidase Complex