title: Evaluation of substituted oxime ethers for growth regulatory activity against Spodoptera litura (Lepidoptera: Noctuidae).
abstract: Insect growth regulator (IGR) activity of 52 substituted oxime ethers was evaluated against an important polyphagous lepidopteran pest, Spodoptera litura (F.) (Lepidoptera: Noctuidae). Several compounds produced symptoms comparable to exogenously applied juvenile hormone. Maximum ICR activity was exhibited by 4'-(2,6,6-trimethyl-2-cyclohexen-1-yl)-3'-buten-2'(E)-ketoxime-N-O-alkyl ether with an ED50 (morphological) of 40 microg g(-1) body weight, compared with 20 microg g(-1) of juvenile hormone (JH) III. Two more compounds, namely, 4'-(2,6,6-trimethyl-2-cyclohexen-1-yl)-3'-buten-2'(Z)-ketoxime-N-O-methyl propyl ether (ED50 of 192 microg g(-1)) and 4'-(2,6,6-trimethyl-1-cyclohexen-1-yl)-3'-buten-2'(E)-ketoxime-N-O-pentyl ether (ED50 of 380 microg g(-1)) showed considerable IGR activity, whereas 4'-(2,6,6-trimethyl-2-cyclohexen-1-yl)-3'-buten-2'(E)-ketoxime-N-O-pentyl ether was found to be acutely toxic to larvae (ED50 of 268 microg g(-1)). Three compounds used in this study also were synergized by piperonyl butoxide. Synergistic ratios ranged from 1.330 to 4.605. No significant ovicidal activity was obtained.
authors.affiliation: Division of Plant Protection, Faculty of Agriculture, Valie Asr University, Rafsanjan 7713936417, Iran. hizadiir@yahoo.com
authors.forename: Hamzeh
authors.initials: H
authors.lastname: Izadi
authors.forename: Balla
authors.initials: B
authors.lastname: Subrahmanyam
authors.forename: Mohammad Amin
authors.initials: MA
authors.lastname: Samih
mesh_terms: D000818:Animals; D004357:Drug Synergism; D004987:Ethers / Q000737:chemistry / Q000494:pharmacology*; D007306:Insecticides / Q000737:chemistry / Q000494:pharmacology*; D007814:Larva / Q000187:drug effects / Q000254:growth & development; D009036:Moths / Q000187:drug effects* / Q000254:growth & development; D010091:Oximes / Q000737:chemistry / Q000494:pharmacology*; D010882:Piperonyl Butoxide / Q000494:pharmacology
chemical_list: D004987:Ethers; D007306:Insecticides; D010091:Oximes; D010882:Piperonyl Butoxide