Acquired factor V inhibitor responsive to corticosteroids in a patient with double cancers.
A 70-year-old woman suffering from HCV-related liver cirrhosis was admitted for abnormal bleeding. Laboratory findings included PT at 46.6 sec, APTT at >212 sec, factor V activity of <3%, and factor V inhibitor of 2 BU. Having experienced a persistent bleeding tendency for one month, the patient was started on prednisolone (0.8 mg/kg/day). Within a few days, the inhibitor became undetectable and clinical bleeding disappeared. Although clinical improvement was achieved, she died 6 months after the initial bleeding episode from the progression of a lung cancer. An autopsy revealed squamous cell carcinoma of the lung and hepatocellular carcinoma.
Endo
Hitoshi
H
Department of Internal Medicine, Tokyo Women's Medical University Medical Center East, Tokyo, Japan. endogm@dnh.twmu.ac.jp <endogm@dnh.twmu.ac.jp>
Kawauchi
Kiyotaka
K
Tomimatsu
Masahiko
M
Iga
Daijiro
D
Ogasawara
Toshie
T
Yasuyama
Masako
M
Saito
Toshihito
T
Otsuka
Kuniaki
K
Aiba
Motohiko
M
D000368:Aged; D019774:Blood Coagulation Factor Inhibitors / Q000037:antagonists & inhibitors* / Q000097:blood*; D006528:Carcinoma, Hepatocellular / Q000097:blood; D002294:Carcinoma, Squamous Cell / Q000097:blood; D005165:Factor V / Q000037:antagonists & inhibitors*; D017809:Fatal Outcome; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use*; D006470:Hemorrhage / Q000188:drug therapy / Q000209:etiology*; D006526:Hepatitis C / Q000150:complications; D006801:Humans; D008103:Liver Cirrhosis / Q000821:virology; D008113:Liver Neoplasms / Q000097:blood; D008175:Lung Neoplasms / Q000097:blood; D009378:Neoplasms, Multiple Primary / Q000097:blood*; D011239:Prednisolone / Q000627:therapeutic use*
D019774:Blood Coagulation Factor Inhibitors; D005938:Glucocorticoids; D005165:Factor V; D011239:Prednisolone