title: Viewing humorous film improves nighttime wakening in children with atopic dermatitis.
abstract: BACKGROUND
  Patients with atopic dermatitis suffered from night-time wakening, but the exact mechanism of it was not known. Ghrelin was involved in growth hormone secretion, regulation of appetite, anxiety,night-time wakening and stress.
  
  
  METHODS
  Thus salivary ghreli levels during the night were measured in 40 healthy children or 40 patients with atopic dermatitis with night-time wakening. Salivary ghrelin levels at 02:00 h were markedly elevated in patients with atopic dermatitis compared to those in healthy children.
  
  
  RESULTS
  Neither viewing control non-humorous film nor viewing humorous film had any effect on healthy children. In contrast, viewing humorous film improved night-time wakening and reduced elevation of salivary ghrelin levels in patients with atopic dermatitis, while viewing control film failed to do so.
  
  
  CONCLUSIONS
  Viewing humorous film may be useful in the treatment of night-time wakening in patients with atopic dermatitis.
authors.affiliation: Department of Allergy, Moriguchi Keijinkai Hospital, Osaka Prefecture, Japan. kimata-keijinkai@mkc.zaq.ne.jp
authors.forename: Hajime
authors.initials: H
authors.lastname: Kimata
mesh_terms: D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D003876:Dermatitis, Atopic / Q000378:metabolism / Q000523:psychology*; D004644:Emotions; D005260:Female; D054439:Ghrelin; D006801:Humans; D007845:Laughter / Q000523:psychology*; D027641:Laughter Therapy; D008297:Male; D009040:Motion Pictures; D036361:Peptide Hormones / Q000378:metabolism*; D012463:Saliva; D007319:Sleep Initiation and Maintenance Disorders / Q000378:metabolism* / Q000517:prevention & control / Q000523:psychology; D013315:Stress, Psychological / Q000150:complications; D014851:Wakefulness
chemical_list: D054439:Ghrelin; D036361:Peptide Hormones