title: Role of intravenously administered hyoscine butyl bromide in retrograde terminal ileoscopy: a randomized, double-blinded, placebo-controlled trial.
abstract: OBJECTIVE
  To evaluated the role of hyoscine butyl bromide in facilitating retrograde ileoscopy.
  
  
  METHODS
  Retrograde terminal ileoscopy was attempted in 200 consecutive patients undergoing colonoscopy. After intubation of the cecum and visualization of the ileocecal valve, butyl bromide injection or normal saline was given intravenously to the patients in a double blind random fashion. The pulse rate and oxygen saturation were measured continuously. After completion of the procedure, endoscopists were then asked to score the ease of intubation and the ease of visualization of the terminal ileum on a visual scale of 1 to 10. The patients were also asked to score the pain after receiving hyoscine butyl bromide injection on a score of 1 to 10.
  
  
  RESULTS
  Terminal ileoscopy could be performed in 188 patients. The mean (SD) visual analogue score for the ease of intubation of the cecum was 7.4 (0.65) in the injection group and 5.9 (0.8) in the placebo group (P < 0.001). The mean (SD) length of ileum visualized in the injection group was 14.4 (3.3) cm and 10.4 (2.7) cm in the placebo group (P < 0.001). The mean (SD) visual analogue score for ease of visualization of the terminal ileum was 7.5 (0.69) in the injection group and 5.9 (0.7) in the placebo group (P < 0.001). The pain score experienced by the patients was 6.5 (0.7) in the injection group and 6.7 (0.69) in the placebo group (P < 0.008). Although the pulse rate increased significantly in patients receiving the drug, no statistically significant difference was noted in the oxygen saturation between the two groups either before or after administration of the drug. No complications were observed in either of the groups.
  
  
  CONCLUSIONS
  Hyoscine butyl bromide injection is a useful adjunct in helping the intubation and visualization of terminal ileum during colonoscopy.
authors.affiliation: Department of Gastroenterology, Moti Lal Nehru Medical College, Allahabad 211001, India. spmisra@sancharnet.in
authors.forename: S P
authors.initials: SP
authors.lastname: Misra
authors.forename: M
authors.initials: M
authors.lastname: Dwivedi
mesh_terms: D000328:Adult; D000368:Aged; D002086:Butylscopolammonium Bromide / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D003113:Colonoscopy / Q000009:adverse effects / Q000379:methods*; D004311:Double-Blind Method; D016099:Endoscopy, Gastrointestinal / Q000379:methods; D005260:Female; D006801:Humans; D007082:Ileum / Q000187:drug effects* / Q000473:pathology; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D018727:Muscarinic Antagonists / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D010146:Pain / Q000209:etiology / Q000517:prevention & control; D010147:Pain Measurement
chemical_list: D018727:Muscarinic Antagonists; D002086:Butylscopolammonium Bromide