title: A case of cutaneous extravascular necrotizing granuloma without systemic manifestations.
abstract: Cutaneous extravascular necrotizing granuloma, an unusual palisading dermal granuloma, was first described by Churg and Strauss in 1951 in association with the syndrome of allergic granulomatosis (Churg-Strauss syndrome), for which it was though to be pathognomonic. It has subsequently been described in association with a number of autoimmune and immunoreactive diseases, and is regarded as a cutaneous marker of systemic pathology. To our knowledge, only one patient has been reported with clinical features confined to the skin. We report a 46-year-old woman with recurrent cutaneous lesions over a 10-year period and the classic histopathological pattern, but no underlying systemic disease.
authors.affiliation: St John's Institute of Dermatology, St Thomas' Hospital, London, UK. lnewell@doctors.org.uk
authors.forename: E L
authors.initials: EL
authors.lastname: Newell
authors.forename: R
authors.initials: R
authors.lastname: Mallipeddi
authors.forename: M E
authors.initials: ME
authors.lastname: Murdoch
authors.forename: R
authors.initials: R
authors.lastname: Groves
authors.forename: M M
authors.initials: MM
authors.lastname: Black
authors.forename: A
authors.initials: A
authors.lastname: Robson
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D015267:Churg-Strauss Syndrome / Q000473:pathology / Q000532:radiotherapy*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008875:Middle Aged; D012867:Skin / Q000473:pathology*; D012871:Skin Diseases / Q000473:pathology / Q000532:radiotherapy*; D016896:Treatment Outcome; D014467:Ultraviolet Therapy / Q000379:methods*
chemical_list: D000305:Adrenal Cortex Hormones