5-lipoxygenase: regulation and possible involvement in atherosclerosis.
This review article focuses on two aspects regarding 5-lipoxygenase. First, mechanisms for activation of the enzyme. Second, the involvement of 5-lipoxygenase and leukotrienes in atherosclerosis.
Rådmark
Olof
O
Department of Medical Biochemistry and Biophysics, Division of Physiological Chemistry II, Karolinska Institute, S-17177 Stockholm, Sweden. olof.radmark@ki.se
Samuelsson
Bengt
B
D000818:Animals; D001094:Arachidonate 5-Lipoxygenase / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D050197:Atherosclerosis / Q000201:enzymology* / Q000453:epidemiology / Q000209:etiology*; D002384:Catalysis; D006801:Humans; D015289:Leukotrienes / Q000378:metabolism; D016859:Lipoxygenase Inhibitors; D008954:Models, Biological; D008958:Models, Molecular; D019913:Nuclear Localization Signals; D010766:Phosphorylation; D017434:Protein Structure, Tertiary
D015289:Leukotrienes; D016859:Lipoxygenase Inhibitors; D019913:Nuclear Localization Signals; D001094:Arachidonate 5-Lipoxygenase