Increased excretion of glycosaminoglycans in children with urinary incontinence compared to those with monosymptomatic nocturnal enuresis.
OBJECTIVE
To analyse the urinary excretion of glycosaminoglycans (GAGs) in patients with either urinary incontinence or nocturnal enuresis.


METHODS
The study population comprised 65 patients with either nocturnal enuresis (n=34) or urinary incontinence (n=31) and 67 controls. Excretion of urinary GAGs was assessed using the sodium tetraborate-carbazole method.


RESULTS
GAG excretion in patients with urinary incontinence was significantly higher than that in controls (p<0.000129) and in children with nocturnal enuresis (p<0.016). There were no age or sex differences in GAG excretion in the three groups studied.


CONCLUSIONS
Increased GAG excretion in patients with urinary incontinence suggests an association with urothelial/detrusor pathology.
Ferrara
Pietro
P
Department of Pediatrics, Università Cattolica S. Cuore, A. Gemelli Hospital, Rome, Italy. pferrara@rm.unicatt.it
Marrone
Giuseppina
G
Mastrangelo
Antonio
A
Nicoletti
Alessandro
A
Emmanuele
Valentina
V
Fasano
Alfonso
A
D000293:Adolescent; D001881:Borates; D002227:Carbazoles; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D018680:Cholinergic Antagonists / Q000627:therapeutic use; D005260:Female; D006025:Glycosaminoglycans / Q000652:urine*; D006801:Humans; D008297:Male; D053206:Nocturnal Enuresis / Q000652:urine*; D011237:Predictive Value of Tests; D001743:Urinary Bladder / Q000473:pathology / Q000503:physiopathology; D014549:Urinary Incontinence / Q000188:drug therapy / Q000652:urine*
D001881:Borates; D002227:Carbazoles; D018680:Cholinergic Antagonists; D006025:Glycosaminoglycans; C041514:carbazole; C010634:sodium borate