title: Enhanced anticancer effect of conjugated linoleic acid by conjugation with Pluronic F127 on MCF-7 breast cancer cells.
abstract: This study is designed to evaluate whether conjugated linoleic acid-coupled Pluronic F127 (Plu-CLA) enhances anticancer efficacy in MCF-7 breast cancer cells when compared to conjugated linoleic acid (CLA) itself. CLA was simply coupled to Pluronic F127 through ester linkage between carboxyl group of CLA and hydroxyl one of Pluronic at melting state without solvent or catalyst. Plu-CLA significantly enhanced apoptosis with increasing concentration compared with CLA itself. Moreover, it was found that p53, p21, and Bax were up-regulated, whereas Bcl-2 and procaspase 9 were down-regulated with increasing concentration of Plu-CLA. These results were attributed to the sensitization activity of Pluronic F127.
authors.affiliation: School of Agricultural Biotechnology, Seoul National University, Seoul 151-921, South Korea.
authors.forename: Ding-Ding
authors.initials: DD
authors.lastname: Guo
authors.forename: Hyun-Seuk
authors.initials: HS
authors.lastname: Moon
authors.forename: Rohidas
authors.initials: R
authors.lastname: Arote
authors.forename: Ji-Hye
authors.initials: JH
authors.lastname: Seo
authors.forename: Ji-Shan
authors.initials: JS
authors.lastname: Quan
authors.forename: Yun-Jaie
authors.initials: YJ
authors.lastname: Choi
authors.forename: Chong-Su
authors.initials: CS
authors.lastname: Cho
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000627:therapeutic use*; D017209:Apoptosis / Q000187:drug effects; D001943:Breast Neoplasms / Q000473:pathology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D005260:Female; D006801:Humans; D044243:Linoleic Acids, Conjugated / Q000627:therapeutic use*; D020442:Poloxamer / Q000627:therapeutic use*
chemical_list: D000970:Antineoplastic Agents; D044243:Linoleic Acids, Conjugated; D020442:Poloxamer