The 4C technique: the 'Rosetta stone' for genome biology in 3D?
Despite considerable efforts, the spatial link between the nuclear architecture and the genome remains enigmatic. The 4C method, independently innovated in four different laboratories, might in combination with other methods change that. As this method is based on the unbiased identification of sequences interacting with specific baits, there are unique opportunities for unravelling the secrets of how the genome functions in 3D.
Ohlsson
Rolf
R
Department of Development & Genetics, Norbyvägen 18A, Evolution Biology Centre, Uppsala University, S-752 36 Uppsala, Sweden. rolf.ohlsson@ebc.uu.se
Göndör
Anita
A
D000818:Animals; D001483:Base Sequence; D001695:Biology; D002874:Chromosome Mapping; D017931:DNA Primers; D004270:DNA, Circular; D005544:Forecasting; D016678:Genome; D015894:Genome, Human; D006801:Humans; D008954:Models, Biological; D008969:Molecular Sequence Data; D021141:Nucleic Acid Amplification Techniques; D009690:Nucleic Acid Conformation; D020411:Oligonucleotide Array Sequence Analysis; D016133:Polymerase Chain Reaction; D017422:Sequence Analysis, DNA
D017931:DNA Primers; D004270:DNA, Circular