Idiopathic transverse myelitis: corticosteroids, plasma exchange, or cyclophosphamide.
Transverse myelitis is a focal disorder of the spinal cord in which an immune-mediated process results in neural injury. In this large retrospective study, we compare patients who received one of four treatments to identify the most effective therapies. We identified subsets of patients who received clinical benefit from plasma exchange or cyclophosphamide being included in their treatment regimen.
Greenberg
B M
BM
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287-5371, USA. bgreenb7@jhmi.edu
Thomas
K P
KP
Krishnan
C
C
Kaplin
A I
AI
Calabresi
P A
PA
Kerr
D A
DA
D000305:Adrenal Cortex Hormones / Q000008:administration & dosage*; D000328:Adult; D001327:Autoimmune Diseases / Q000150:complications / Q000276:immunology; D015984:Causality; D003520:Cyclophosphamide / Q000008:administration & dosage*; D004185:Disability Evaluation; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D009188:Myelitis, Transverse / Q000188:drug therapy* / Q000276:immunology / Q000503:physiopathology; D010956:Plasmapheresis / Q000592:standards* / Q000706:statistics & numerical data; D012189:Retrospective Studies; D013116:Spinal Cord / Q000187:drug effects* / Q000276:immunology / Q000503:physiopathology; D016896:Treatment Outcome
D000305:Adrenal Cortex Hormones; D007166:Immunosuppressive Agents; D003520:Cyclophosphamide