title: Dual infection with polyomavirus BK and acyclovir-resistant herpes simplex virus successfully treated with cidofovir in a bone marrow transplant recipient.
abstract: A hematopoietic stem cell transplant recipient developed a mucosal herpes simplex virus-1 (HSV-1) infection while under acyclovir (ACV) treatment (HSV was later shown to be resistant to ACV). Concomitantly, the patient presented a hemorrhagic cystitis (HC) due to polyomavirus BK, for which intravenous cidofovir (CDV) was prescribed. The patient benefited from the broad-spectrum anti-DNA virus activity of CDV, and not only the HC resolved without signs of nephrotoxicity but also the HSV-1 lesions disappeared. This is the first report describing the effect of CDV on 2 simultaneous and unrelated DNA viral infections in an immunosuppressed transplant recipient. In addition, we describe here that this HSV-1 isolate possesses a unique phenotype and genotype.
authors.affiliation: Laboratory of Virology, Rega Institute for Medical Research, K.U. Leuven, Leuven, Belgium.
authors.forename: G
authors.initials: G
authors.lastname: Andrei
authors.forename: P
authors.initials: P
authors.lastname: Fiten
authors.forename: P
authors.initials: P
authors.lastname: Goubau
authors.forename: H
authors.initials: H
authors.lastname: van Landuyt
authors.forename: B
authors.initials: B
authors.lastname: Gordts
authors.forename: D
authors.initials: D
authors.lastname: Selleslag
authors.forename: E
authors.initials: E
authors.lastname: De Clercq
authors.forename: G
authors.initials: G
authors.lastname: Opdenakker
authors.forename: R
authors.initials: R
authors.lastname: Snoeck
mesh_terms: D000212:Acyclovir / Q000627:therapeutic use*; D000293:Adolescent; D000998:Antiviral Agents / Q000627:therapeutic use*; D001739:BK Virus; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D000077404:Cidofovir; D003596:Cytosine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D024882:Drug Resistance, Viral; D005260:Female; D006561:Herpes Simplex / Q000150:complications / Q000188:drug therapy*; D018259:Herpesvirus 1, Human / Q000302:isolation & purification*; D006801:Humans; D063065:Organophosphonates / Q000627:therapeutic use*; D027601:Polyomavirus Infections / Q000150:complications / Q000188:drug therapy*; D014412:Tumor Virus Infections / Q000150:complications / Q000188:drug therapy*
chemical_list: D000998:Antiviral Agents; D063065:Organophosphonates; D003596:Cytosine; D000077404:Cidofovir; D000212:Acyclovir