title: A rhodium(I)-catalyzed demethylation-cyclization of o-anisole-substituted ynamides in the synthesis of chiral 2-amido benzofurans.
abstract: A Rh(I)-catalyzed demethylation-cyclization sequence for a direct transformation of o-anisole-substituted ynamides to benzofurans is described here. The Ag salt functions synergistically with Rh(I) for the key demethylation step.
authors.affiliation: Division of Pharmaceutical Sciencies and Department of Chemistry, University of Wisconsin-Madison, Rennebohm Hall, 777 Highland Avenue, Madison, Wisconsin 53705-2222, USA.
authors.forename: Jossian
authors.initials: J
authors.lastname: Oppenheimer
authors.forename: Whitney L
authors.initials: WL
authors.lastname: Johnson
authors.forename: Michael R
authors.initials: MR
authors.lastname: Tracey
authors.forename: Richard P
authors.initials: RP
authors.lastname: Hsung
authors.forename: Pei-Yuan
authors.initials: PY
authors.lastname: Yao
authors.forename: Renhe
authors.initials: R
authors.lastname: Liu
authors.forename: Kang
authors.initials: K
authors.lastname: Zhao
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D000577:Amides / Q000737:chemistry*; D000840:Anisoles / Q000737:chemistry*; D001572:Benzofurans / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D018360:Crystallography, X-Ray; D003500:Cyclization; D008745:Methylation; D008958:Models, Molecular; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D012238:Rhodium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000480:Alkynes; D000577:Amides; D000840:Anisoles; D001572:Benzofurans; D009942:Organometallic Compounds; C060998:anisole; D012238:Rhodium