Xp11 translocation carcinoma of the kidney presenting with multilocular cystic renal cell carcinoma-like features.
Reported is the case of a 17-year-old girl with a multicystic tumor in the middle of the right kidney. Partial nephrectomy revealed an epithelial neoplasm with multilocular cystic renal cell carcinoma pattern. The cells exhibited strong nuclear reactivity for TFE3 protein and supported the diagnosis of Xp11 translocation carcinoma of the kidney. A similar case has not been found in the literature. The example emphasizes the high index of suspicion needed for an accurate diagnosis of renal carcinomas.
Suzigan
Sueli
S
Laborclin Lab, School of Medicine, São José do Rio Preto, SP, Brazil. larpac@riopreto.com.br
Drut
Ricardo
R
Faria
Paulo
P
Argani
Pedram
P
De Marzo
Angelo M
AM
Barbosa
Rui Nogueira
RN
Mello Denadai
Eliseu Roberto
ER
Martins-Filho
Júlio
J
Martucci
Rubens Carlos
RC
Bauab
Tufik
T
D000293:Adolescent; D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / Q000378:metabolism; D002292:Carcinoma, Renal Cell / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D002467:Cell Nucleus / Q000378:metabolism / Q000473:pathology; D002878:Chromosomes, Human, Pair 1; D041321:Chromosomes, Human, X; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D009392:Nephrectomy; D014178:Translocation, Genetic
D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; C069203:TFE3 protein, human