title: The adipose renin-angiotensin system modulates systemic markers of insulin sensitivity and activates the intrarenal renin-angiotensin system.
abstract: BACKGROUND
  The adipose tissue renin-angiotensin system (RAS) contributes to regulation of fat mass and may also impact systemic functions such as blood pressure and metabolism.
  
  
  RESULTS
  A panel of mouse models including mice lacking angiotensinogen, Agt (Agt-KO), mice expressing Agt solely in adipose tissue (aP2-Agt/Agt-KO), and mice overexpressing Agt in adipose tissue (aP2-Agt) was studied. Total body weight, epididymal fat pad weight, and circulating levels of leptin, insulin, and resistin were significantly decreased in Agt-KO mice, while plasma adiponectin levels were increased. aP2-Agt mice exhibited increased adiposity and plasma leptin and insulin levels compared to wild type (WT) controls. Angiotensinogen and type I Ang II receptor protein levels were also elevated in kidney of aP2-Agt mice.
  
  
  CONCLUSIONS
  These findings demonstrate that alterations in adipose RAS activity significantly impact both local and systemic physiology in a way that may contribute to the detrimental health effects of obesity.
authors.affiliation: Department of Nutrition and Agricultural Experiment Station, University of Tennessee, Knoxville, TN 37996, USA.
authors.forename: Suyeon
authors.initials: S
authors.lastname: Kim
authors.forename: Morvarid
authors.initials: M
authors.lastname: Soltani-Bejnood
authors.forename: Annie
authors.initials: A
authors.lastname: Quignard-Boulange
authors.forename: Florence
authors.initials: F
authors.lastname: Massiera
authors.forename: Michele
authors.initials: M
authors.lastname: Teboul
authors.forename: Gerard
authors.initials: G
authors.lastname: Ailhaud
authors.forename: Jung Han
authors.initials: JH
authors.lastname: Kim
authors.forename: Naima
authors.initials: N
authors.lastname: Moustaid-Moussa
authors.forename: Brynn H
authors.initials: BH
authors.lastname: Voy