title: Identification of four new HLA-Cw alleles in the Sudanese population.
abstract: The major histocompatibility complex (MHC) is the most polymorphic region of the human genome. Human leukocyte antigen-C (HLA-C) genes are located in the class I region of MHC. Most polymorphisms of HLA class I antigens are present in exons 2 and 3, which encode the alpha1 and alpha2 domains of the HLA-A heavy chain, involved in both peptide binding and HLA-restricted recognition by the T-cell receptor. Four new HLA-Cw alleles were identified in the Sudanese population during HLA class I and class II sequencing-based typing at the HLA-C locus of case-control study of Sudanese HIV patients, in individuals from different ethnic background. Based on the localization of the affected amino acid positions in an outer loop of the alpha-helix forming the side of the peptide-binding groove, we do not expect the replacement mutations to have an effect on peptide binding or T-cell receptor interaction.
authors.affiliation: Institute for Transfusion Medicine, Hannover Medical School, Hannover, Germany.
authors.forename: N E
authors.initials: NE
authors.lastname: Elamin
authors.forename: M I
authors.initials: MI
authors.lastname: Elbashir
authors.forename: I M
authors.initials: IM
authors.lastname: Elkhidir
authors.forename: G
authors.initials: G
authors.lastname: Elghazali
authors.forename: R
authors.initials: R
authors.lastname: Blasczyk
authors.forename: P A
authors.initials: PA
authors.lastname: Horn
mesh_terms: D000483:Alleles; D016022:Case-Control Studies; D005260:Female; D015236:HLA-C Antigens / Q000235:genetics*; D006801:Humans; D008297:Male; D017433:Protein Structure, Secondary / Q000235:genetics; D017434:Protein Structure, Tertiary / Q000235:genetics; D013397:Sudan
chemical_list: D015236:HLA-C Antigens