[Free radical oxidation in children with severe craniocerebral injury].
Changes in the products of lipid peroxidation (LPO) and the antioxidative system (AOS) were studied in 94 children aged 3 to 15 years with severe brain injury (BI) on days 1, 3-5, and 7-10. The contents of dienic conjugates and malonic dialdehyde and the level of induced peroxide hemolysis and peroxide resistance of red blood cells in the plasma were determined. Children with severe BI were found to have activated LPO processes and decreased AOS activity, the most significant changes occurring within 24 hours of injury. The increased activity of peroxide processes was attended by reverse AOS changes. In children, the time course of changes in the parameters of LPO and AOS differs from that in adults since there is no phase of excessive LPO activation due to the exhaustion of AOS reserves.
Aleksandrovich
Iu S
IuS
Arutsova
I Iu
IIu
L'vov
S N
SN
Kaziakhmedov
V A
VA
D002648:Child; D006259:Craniocerebral Trauma / Q000097:blood / Q000378:metabolism*; D004912:Erythrocytes / Q000378:metabolism; D005260:Female; D005609:Free Radicals / Q000378:metabolism*; D006461:Hemolysis; D006801:Humans; D008054:Lipid Peroxides / Q000097:blood; D008297:Male; D013997:Time Factors; D015599:Trauma Severity Indices
D005609:Free Radicals; D008054:Lipid Peroxides