Menopause, estrogens, progestins, or their combination on body weight and anthropometric measures.
OBJECTIVE
To evaluate modification in body weight and anthropometric indexes in women at the time of menopause.


METHODS
Prospective longitudinal study.


METHODS
Menopause Center at the University Hospital of Modena.


METHODS
Women in perimenopause (n = 87), ovariectomized (n = 60), and in postmenopause (n = 182) without and with treatment.


METHODS
Data were retrieved from the electronic database of the Menopause Center.


METHODS
Modification of weight, body mass index (BMI), waist, hip, and waist-to-hip ratio in 12 months.


RESULTS
Body weight increased in perimenopausal (0.6 +/- 0.1 kg) women, did not vary in postmenopausal (0.2 +/- 0.1 kg) women, and decreased in ovariectomized (-0.5 +/- 0.3 kg) women. Waist increased significantly in perimenopausal (2.3 +/- 0.4 cm) and in postmenopausal (2.0 +/- 0.4 cm) women. In comparison to no treatment, progestin administration (n = 29) decreased body weight (-0.2 +/- 0.5 kg) and hip (-1.1 +/- 0.9 cm) in perimenopausal women, estrogen (E) administration (n = 38) increased body weight (0.8 +/- 0.3 kg) in ovariectomized women, whereas E plus progestin administration (n = 89) did not induce any modification in postmenopausal women.


CONCLUSIONS
Present preliminary data indicate that body weight increases in perimenopausal women, decreases in ovariectomized women, and does not increase significantly in naturally postmenopausal women. Estrogens and progestins influence body weight differently, increasing and decreasing it, respectively.
Cagnacci
Angelo
A
Department of Obstetrics Gynecology and Pediatrics, University of Modena, Modena, Italy. cagnacci@unimore.it
Zanin
Renata
R
Cannoletta
Marianna
M
Generali
Matteo
M
Caretto
Simona
S
Volpe
Annibale
A
D000886:Anthropometry; D001835:Body Weight / Q000187:drug effects* / Q000502:physiology; D001837:Body Weights and Measures; D016208:Databases, Factual; D004359:Drug Therapy, Combination; D015914:Estrogen Replacement Therapy; D004967:Estrogens / Q000008:administration & dosage*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007044:Hysterectomy; D008593:Menopause / Q000187:drug effects / Q000502:physiology*; D008594:Menopause, Premature / Q000187:drug effects; D008875:Middle Aged; D010052:Ovariectomy; D047648:Perimenopause / Q000502:physiology; D011372:Progestins / Q000008:administration & dosage*; D012189:Retrospective Studies
D004967:Estrogens; D011372:Progestins