In vitro degradation and release profiles for Poly-dl-lactide film containing paracetamol.
The biodegradable film containing paracetamol with suitable dimensions was prepared by polymer solution-cast method. The study mainly investigated the in vitro degradation of the films without and with 7.0% and 14% paracetamol in the phosphate-buffer saline (PBS) of pH 7.4 at 37 degrees C. The results showed that the degradation rate for the film with same dimensions containing more drug was faster. The in vitro drug release profiles showed that paracetamol release from film matrix was almost sustained within one month. It suggested that the biodegradable film should be potential in preventing tissue adhesion and local inflammation on operating procedure.
Zhou
Shaobing
S
School of Materials Science and Engineering, Key Laboratory of Advanced Technologies of Materials, Ministry of Education, Southwest Jiaotong University, Chengdu 610031, P.R. China. shaobingzhou@hotmail.com
Song
Bing
B
Li
Xiaohong
X
D020341:Absorbable Implants; D000082:Acetaminophen / Q000008:administration & dosage / Q000737:chemistry*; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage / Q000737:chemistry; D001826:Body Fluids / Q000737:chemistry*; D002214:Capsules / Q000737:chemistry; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000737:chemistry*; D004058:Diffusion; D004337:Drug Carriers / Q000008:administration & dosage / Q000737:chemistry*; D004339:Drug Compounding / Q000379:methods; D004355:Drug Stability; D006493:Heparin / Q000008:administration & dosage* / Q000737:chemistry*; D007700:Kinetics; D011091:Polyesters / Q000737:chemistry*
D018712:Analgesics, Non-Narcotic; D002214:Capsules; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D011091:Polyesters; D000082:Acetaminophen; C033616:poly(lactide); D006493:Heparin