Association study of PTPN22 C1858T polymorphism in Trypanosoma cruzi infection.
In this study we investigated a possible role for the single nucleotide polymorphism C1858T of the PTPN22 (protein tyrosine phosphatase nonreceptor 22) gene in determining the susceptibility to Trypanosoma cruzi infection, as well as in development of chagasic heart disease. This study included 316 patients with Chagas' disease and 520 healthy individuals from Colombia and Peru. Genotyping of PTPN22 was performed by the real-time polymerase chain reaction technology, using the TaqMan 5' allelic discrimination assay. No statistically significant differences in the frequency of PTPN22 C1858T gene polymorphism between chagasic patients and controls or between asymptomatic and cardiomyopathic individuals were observed. Our findings suggest that the PTPN22 polymorphism analyzed does not play a major role in the development of Chagas' disease in the Colombian and Peruvian populations.
Robledo
G
G
Instituto de Parasitología y Biomedicina López-Neyra, CSIC, Granada, Spain.
González
C I
CI
Morillo
C
C
Martín
J
J
González
A
A
D024506:5' Flanking Region / Q000235:genetics; D000328:Adult; D000368:Aged; D000483:Alleles; D000818:Animals; D002598:Chagas Cardiomyopathy / Q000235:genetics*; D003105:Colombia; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010568:Peru; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D054596:Protein Tyrosine Phosphatase, Non-Receptor Type 22; D017027:Protein Tyrosine Phosphatases / Q000235:genetics*; D014349:Trypanosoma cruzi
C516765:PTPN22 protein, human; D054596:Protein Tyrosine Phosphatase, Non-Receptor Type 22; D017027:Protein Tyrosine Phosphatases