Reversible acetylation of non histone proteins: role in cellular function and disease.
Post-translational modifications of nonhistone proteins play a significant role in regulating the chromatin structure, dynamics and thereby gene regulation. Among the different posttranslational modifications, reversible acetylation of non-histone proteins has profound functional implications on wide range of cellular processes. The acetylation status of these proteins is regulated by several cellular and non-cellular factors like viruses, physiological stresses, DNA damaging agents and ROS. Mutations found in the acetylation sites of these proteins and aberrant acetylation are related to imbalances in different cellular pathways and various diseases. Several factor acetyltransferases and deacetylases are known to regulate the acetylation of the nonhistone proteins. Modulators of these enzymes derived from natural as well as synthetic sources can thus have important therapeutic implications. Designing strategies to specifically target the acetylation of these proteins can be used as a valuable tool for new generation drugs
Batta
Kiran
K
Transcription and Disease Laboratory, Molecular Biology and Genetics Unit. Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bangalore-64, India.
Das
Chandrima
C
Gadad
Shrikanth
S
Shandilya
Jayasha
J
Kundu
Tapas K
TK
D000107:Acetylation; D000123:Acetyltransferases / Q000378:metabolism*; D000818:Animals; D017209:Apoptosis; D002318:Cardiovascular Diseases / Q000235:genetics / Q000378:metabolism; D002453:Cell Cycle; D002843:Chromatin / Q000378:metabolism*; D042002:Chromatin Assembly and Disassembly; D002868:Chromosomal Proteins, Non-Histone / Q000378:metabolism*; D004249:DNA Damage; D004260:DNA Repair; D003920:Diabetes Mellitus / Q000235:genetics / Q000378:metabolism; D051548:Histone Acetyltransferases / Q000378:metabolism; D006655:Histone Deacetylases / Q000378:metabolism; D006801:Humans; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism; D018384:Oxidative Stress; D011499:Protein Processing, Post-Translational; D014158:Transcription, Genetic; D014777:Virus Diseases / Q000235:genetics / Q000378:metabolism
D002843:Chromatin; D002868:Chromosomal Proteins, Non-Histone; D000123:Acetyltransferases; D051548:Histone Acetyltransferases; D006655:Histone Deacetylases