title: Quinolone alkaloids from evodiae fructus and their inhibitory effects on monoamine oxidase.
abstract: 1-Methyl-2-undecyl-4(1H)-quinolone (1) was previously isolated as a selective MAO-B inhibitor from the Evodiae Fructus. Further bioassay-guided purification led to the identification of five known quinolone alkaloids, 1-methyl-2-nonyl-4(1H)-quinolone (2), 1-methyl-2-[(Z)-6-undecenyl]-4(1H)-quinolone (3), evocarpine (4), 1-methyl-2-[(6Z,9Z)-6,9-pentadecadienyl]-4(1H)-quinolone (5), and dihydroevocarpine (6). All the isolates showed more potent inhibitory effects against MAO-B compared to MAO-A. The most MAO-B selective compound 5 among the isolates inhibited MAO-B in a competitive manner, according to kinetic analyses by Lineweaver-Burk reciprocal plots.
authors.affiliation: College of Pharmacy, Chungbuk National University, Cheongju, Korea.
authors.forename: Xiang Hua
authors.initials: XH
authors.lastname: Han
authors.forename: Seong Su
authors.initials: SS
authors.lastname: Hong
authors.forename: Dongho
authors.initials: D
authors.lastname: Lee
authors.forename: Jung Joon
authors.initials: JJ
authors.lastname: Lee
authors.forename: Moon Soon
authors.initials: MS
authors.lastname: Lee
authors.forename: Dong-Cheul
authors.initials: DC
authors.lastname: Moon
authors.forename: Kun
authors.initials: K
authors.lastname: Han
authors.forename: Ki-Wan
authors.initials: KW
authors.lastname: Oh
authors.forename: Myung Koo
authors.initials: MK
authors.lastname: Lee
authors.forename: Jai Seup
authors.initials: JS
authors.lastname: Ro
authors.forename: Bang Yeon
authors.initials: BY
authors.lastname: Hwang
mesh_terms: D000470:Alkaloids / Q000302:isolation & purification* / Q000494:pharmacology; D032086:Evodia / Q000737:chemistry*; D008996:Monoamine Oxidase Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology; D015363:Quinolones / Q000302:isolation & purification* / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000470:Alkaloids; D008996:Monoamine Oxidase Inhibitors; D015363:Quinolones