Importance of interaction between C1 domain and lipids in protein kinase C alpha activation: hydrophobic side chain direction in isobenzofuranone ligands controls enzyme activation level.
Hirai
Go
G
Synthetic Organic Chemistry Laboratory, RIKEN, 2-1, Hirosawa, Wako-shi, Saitama 351-0198, Japan.
Shimizu
Tadashi
T
Watanabe
Toru
T
Ogoshi
Yosuke
Y
Ohkubo
Megumi
M
Sodeoka
Mikiko
M
D004789:Enzyme Activation; D005663:Furans / Q000737:chemistry / Q000378:metabolism*; D006860:Hydrogen Bonding; D008024:Ligands; D008958:Models, Molecular; D051571:Protein Kinase C-alpha / Q000378:metabolism*; D013329:Structure-Activity Relationship
D005663:Furans; D008024:Ligands; D051571:Protein Kinase C-alpha