Spleen autotransplantation. Morphological and functional follow-up after spleen autotransplantation in mice: a research summary.
In 1986, we started the research on spleen surgery aimed at saving the splenic mass after its traumatic injury, with elaboration of special resection and autotransplantation techniques. The researches started on mongrel dogs and were continued on inbred mice and beagle dogs with complex histological, imaging, and laboratory investigations, following-up the function and the regeneration of autotransplanted spleen chips. Performing research on mice provided more immunological methods, such as lymphocyte subsets, immunoglobulin levels, and monitoring the phagocytic functions. Researches showed evidence also on the presence of apoptosis, furthermore, stem cell studies on regeneration and functional restoration of the spleen chips are in progress. Our results contributed to two multidisciplinary guidelines in Hungary: (1) One of them is under preparation and underlines the importance of spleen saving methods after traumatic splenic injury; (2) The second guideline shows that hemorheological changes can be early indicators of the increased sensitivity to postsplenectomy infections.
Miko
Iren
I
Department of Operative Techniques and Surgical Research, Institute of Surgery, University of Debrecen, Medical and Health Science Center, H-4032 Debrecen, Nagyerdei krt. 98, Hungary. imiko@dote.hu
Brath
Endre
E
Nemeth
Norbert
N
Furka
Andrea
A
Sipka
Sandor
S
Peto
Katalin
K
Serfozo
Jozsef
J
Kovacs
Judit
J
Imre
Sandor
S
Benko
Ilona
I
Galuska
Laszlo
L
Sipka
Sandor
S
Acs
Geza
G
Furka
Istvan
I
D000328:Adult; D000818:Animals; D004285:Dogs; D006801:Humans; D008137:Longitudinal Studies; D051379:Mice; D008815:Mice, Inbred Strains; D023421:Models, Animal; D017410:Practice Guidelines as Topic; D012038:Regeneration; D013154:Spleen / Q000473:pathology / Q000502:physiology / Q000637:transplantation*; D013156:Splenectomy; D014182:Transplantation, Autologous / Q000379:methods / Q000502:physiology