STAMPing out Inflammation.
Mounting evidence suggests that inflammatory signaling pathways are central players in the pathogenesis of insulin resistance and type 2 diabetes. In this issue, Wellen et al. (2007) identify STAMP2 as a factor that integrates inflammatory and nutritional signals with metabolism.
Waki
Hironori
H
Howard Hughes Medical Institute and Department of Pathology and Laboratory Medicine, University of California, Los Angeles, CA 90095, USA.
Tontonoz
Peter
P
D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism*; D007249:Inflammation / Q000378:metabolism*; D007333:Insulin Resistance; D008565:Membrane Proteins / Q000378:metabolism*; D053858:Metabolic Networks and Pathways; D024821:Metabolic Syndrome / Q000378:metabolism; D051379:Mice; D009765:Obesity / Q000378:metabolism
D008565:Membrane Proteins; C436323:Tiarp protein, mouse