title: Central nervous system depressant activity of an ethyl acetate extract from Ipomoea stans roots.
abstract: Ipomoea stans Cav., popularly known as "tumbavaqueros", is a plant widely used in Mexico for the treatment of epileptic seizures and nervous disorders. This work researched the action of the ethyl acetate extract from the root of I. stans (IS-EAE) on the central nervous system (CNS). The administration of IS-EAE (2.5 and 5.0 mg/kg, i.p.) produced an anxiolytic effect in mice. This extract (20.0 and 40.0 mg/kg, i.p.) significantly reduced spontaneous motor activity. 2.5, 5.0, 10.0, and 20.0 mg/kg of IS-EAE protected mice against pentylenetetrazole-induced convulsions and increased the hypnotic effect induced by pentobarbital. The administration of IS-EAE was able to increase the release of GABA in brain cortex of mice. These results suggest that IS-EAE possess anxiolytic and anticonvulsant effects, and could have potential sedative effect, probably through a GABAergic system. The extract did not show antidepressant effects on mice exposed to forced swimming test.
authors.affiliation: Centro de Investigación Biomédica del Sur, IMSS, Argentina 1, Col. Centro 62790 Xochitepec, Morelos, México.
authors.forename: Maribel
authors.initials: M
authors.lastname: Herrera-Ruiz
authors.forename: Carmen
authors.initials: C
authors.lastname: Gutiérrez
authors.forename: J
authors.initials: J
authors.lastname: Enrique Jiménez-Ferrer
authors.forename: Jaime
authors.initials: J
authors.lastname: Tortoriello
authors.forename: Gumersindo
authors.initials: G
authors.lastname: Mirón
authors.forename: Ismael
authors.initials: I
authors.lastname: León
mesh_terms: D000085:Acetates; D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology; D000927:Anticonvulsants / Q000494:pharmacology; D000928:Antidepressive Agents / Q000494:pharmacology; D002492:Central Nervous System Depressants / Q000494:pharmacology*; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism; D006993:Hypnotics and Sedatives / Q000494:pharmacology; D027741:Ipomoea / Q000737:chemistry*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009043:Motor Activity / Q000187:drug effects; D018377:Neurotransmitter Agents / Q000378:metabolism; D010424:Pentobarbital / Q000494:pharmacology; D010433:Pentylenetetrazole; D010936:Plant Extracts / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D012640:Seizures / Q000139:chemically induced / Q000517:prevention & control; D012997:Solvents; D013550:Swimming / Q000523:psychology; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
chemical_list: D000085:Acetates; D014151:Anti-Anxiety Agents; D000927:Anticonvulsants; D000928:Antidepressive Agents; D002492:Central Nervous System Depressants; D006993:Hypnotics and Sedatives; D018377:Neurotransmitter Agents; D010936:Plant Extracts; D012997:Solvents; D005680:gamma-Aminobutyric Acid; C007650:ethyl acetate; D010424:Pentobarbital; D010433:Pentylenetetrazole