title: The influence of cooling rate on the accuracy of normoxic polymer gel dosimeters.
abstract: Polymer gel dosimeters offer a wide range of applications in the three-dimensional verification of complex radiation dose distributions such as in intensity-modulated radiotherapy (IMRT). With the release of polymer gel dosimeters that can be fabricated in normal atmospheric ('normoxic') conditions, the gel manufacturing process has been significantly simplified. Gel dosimeters are calibrated by use of a series of calibration vials irradiated with known doses or by use of a calibration phantom with a known dose distribution. The overall accuracy of the polymer gel dosimeters is determined by different dosimetric properties. In this study, we show the influence of the temperature history during storage of the gel dosimeter on the dose response curve for two gel dosimeters using the monomers acrylamide/N,N'-methylene-bis-acrylamide (nPAG) and methacrylic acid (nMAG) respectively and bis[tetrakis(hydroxymethyl)phosphonium]sulphate (THP) as antioxidant in both gel dosimeters. This study reveals that differences in temperature history after fabrication of normoxic polymer gel dosimeters may compromise the dosimetric accuracy. It was found that the acrylamide based gel dosimeter (nPAG) is less dependent on the post-manufacture temperature history than the methacrylic acid based gel dosimeter (nMAG). The importance of an equal temperature history for the gel dosimeter and calibration vials is emphasized by this study. A reproducibility study has also been performed on the nPAG gel dosimeter when additional efforts are made to control the temperature changes upon cooling.
authors.affiliation: Radiotherapy and Nuclear Medicine, Ghent University Hospital, De Pintelaan 185, 9000 Gent, Belgium. Yves.DeDeene@UGent.be
authors.forename: Y
authors.initials: Y
authors.lastname: De Deene
authors.forename: G
authors.initials: G
authors.lastname: Pittomvils
authors.forename: S
authors.initials: S
authors.lastname: Visalatchi
mesh_terms: D000178:Acrylamides / Q000737:chemistry*; D000180:Acrylic Resins / Q000737:chemistry*; D000975:Antioxidants / Q000737:chemistry; D005782:Gels; D008689:Methacrylates / Q000737:chemistry*; D011874:Radiometry / Q000295:instrumentation*; D050397:Radiotherapy, Intensity-Modulated / Q000295:instrumentation; D015203:Reproducibility of Results; D013696:Temperature
chemical_list: D000178:Acrylamides; D000180:Acrylic Resins; D000975:Antioxidants; D005782:Gels; D008689:Methacrylates; C008384:methacrylic acid; C021221:N,N'-methylenebisacrylamide