Eosinophil trafficking in allergy and asthma.
Blood eosinophilia and tissue eosinophilia are characteristic features of allergic inflammation and asthma, conditions associated with prominent production of T(H)2 cytokines IL-4, IL-5, and IL-13. In this review, we will consider recent advances in our understanding of the molecular mechanisms that promote expansion and differentiation of eosinophil progenitors in bone marrow, eosinophil recruitment in response to chemokine receptor 3 agonists eosinophil transit mediated by specific ligand-receptor interactions, and prolonged survival of eosinophils in peripheral tissues. Novel rational therapies including antiselectin and antichemokine receptor modalities designed to block eosinophil development and trafficking are discussed, together with the implications of recent clinical studies that have evaluated the efficacy of humanized anti-IL-5 mAb therapy.
Rosenberg
Helene F
HF
Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. hrosenberg@niaid.nih.gov
Phipps
Simon
S
Foster
Paul S
PS
D000818:Animals; D001249:Asthma / Q000276:immunology / Q000473:pathology*; D002465:Cell Movement / Q000276:immunology*; D004804:Eosinophils / Q000166:cytology / Q000276:immunology / Q000473:pathology*; D006801:Humans