Relationship between insulin resistance and serum levels of adiponectin and resistin with childhood obesity.
OBJECTIVE
The aim is to study the relationship between insulin resistance and serum adiponectin and resistin in obese children.


METHODS
A total 113 obese and 37 nonobese children were enrolled and serum adiponectin and resistin were measured.


RESULTS
Compared with controls, higher insulin resistance by homeostasis model (HOMA-IR) and lower whole body insulin resistance index (WBISI)were found in obese children (all P <0.05). The adiponectin levels in obese children and controls were 3.63 and 5.79 microg/L with a significant difference (P<0.001) while the difference of resistin levels was not significant (P = 0.948). Significant correlations between insulin resistance parameter and age,sexual development, BMI, serum triglyceride, ApoB, LDL-cholesterol, HDL-cholesterol, alanine aminotransferase, uric acid, or adiponectin levels (all P <0.05) were noted. Stepwise multiple regression analysis showed that BMI and adiponectin levels were independent determinants of WBISI.


CONCLUSIONS
These results suggest that adiponectin may play a protective role in obese children through decreasing insulin resistance.
Zou
Chao Chun
CC
Children's Hospital of Zhejiang University School of Medicine, 57 Zhugan Xiang, Hangzhou 310 003, China.
Liang
Li
L
Hong
Fang
F
D052242:Adiponectin / Q000097:blood*; D000293:Adolescent; D016022:Case-Control Studies; D002648:Child; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D009765:Obesity / Q000453:epidemiology / Q000378:metabolism* / Q000503:physiopathology; D052243:Resistin / Q000097:blood*; D012307:Risk Factors
D052242:Adiponectin; D052243:Resistin