title: Antitumor anthraquinones from an endophytic actinomycete Micromonospora lupini sp. nov.
abstract: Two novel anthraquinones, lupinacidins A (1) and B (2), have been isolated from the culture broth of a new endophytic actinomycete belonging to the genus Micromonospora. Lupinacidins were found to show significant inhibitory effects on the invasion of murine colon 26-L5 carcinoma cells without inhibiting cell growth.
authors.affiliation: Biotechnology Research Center, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama, Japan. yas@pu-toyama.ac.jp <yas@pu-toyama.ac.jp>
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Igarashi
authors.forename: Martha E
authors.initials: ME
authors.lastname: Trujillo
authors.forename: Eustoquio
authors.initials: E
authors.lastname: Martínez-Molina
authors.forename: Saeko
authors.initials: S
authors.lastname: Yanase
authors.forename: Satoshi
authors.initials: S
authors.lastname: Miyanaga
authors.forename: Takamasa
authors.initials: T
authors.lastname: Obata
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Sakurai
authors.forename: Ikuo
authors.initials: I
authors.lastname: Saiki
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Fujita
authors.forename: Tamotsu
authors.initials: T
authors.lastname: Furumai
mesh_terms: D000818:Animals; D000880:Anthraquinones / Q000138:chemical synthesis* / Q000737:chemistry; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D003110:Colonic Neoplasms / Q000188:drug therapy; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008847:Micromonospora; D008956:Models, Chemical; D008968:Molecular Conformation
chemical_list: D000880:Anthraquinones; D000970:Antineoplastic Agents