title: Pre- and post-transplant monitoring of soluble CD30 levels as predictor of acute renal allograft rejection.
abstract: Identification of renal graft candidates at high risk of impending acute rejection (AR) and graft loss may be helpful for patient-tailored immunosuppressive regimens and renal graft survival. To investigate the feasibility with soluble CD30 (sCD30) as predictor of AR, sCD30 levels of 70 patients were detected on day 0 pre-transplant and day 1, 3, 5, 7, 10, 14, 21, and 30 post-transplant. AR episodes in 6 months were recorded and then patients were divided into Group AR (n=11) and Group UC (n=59). Results showed that the patients had higher pre-transplant sCD30 levels than healthy people. A significant decrease of sCD30 was observed on the first day post-transplant and continued until day 14 post-transplant. Soluble CD30 presented a stable level from day 14 to 30 post-transplant. Pre-transplant sCD30 levels of Group AR were much higher than those of Group UC (P<0.001). Patients of Group AR also had higher sCD30 levels than those of Group UC on day 1, 3, 5, 7, 10 and 14 (P<0.001). The sCD30 level presented a significantly delayed decrease in the patients of Group AR. Statistical results showed that the highest value of area under ROC curve (0.95) was obtained on day 5 post-transplant, suggesting that sCD30 levels on day 5 are of high predictive value. Therefore, sCD30 level may be a good marker of increased alloreactivity and of significant predictive value. It's necessary to monitor the variation of sCD30 in the early period post-transplant.
authors.affiliation: Organ Transplant Institute, Fuzhou General Hospital, No.156 Xi'erhuan North Road, Fuzhou, 350025, China.
authors.forename: Dong
authors.initials: D
authors.lastname: Wang
authors.forename: Guo-Jun
authors.initials: GJ
authors.lastname: Wu
authors.forename: Wei-Zhen
authors.initials: WZ
authors.lastname: Wu
authors.forename: Shun-Liang
authors.initials: SL
authors.lastname: Yang
authors.forename: Jin-Hua
authors.initials: JH
authors.lastname: Chen
authors.forename: He
authors.initials: H
authors.lastname: Wang
authors.forename: Wen-Hong
authors.initials: WH
authors.lastname: Lin
authors.forename: Qing-Hua
authors.initials: QH
authors.lastname: Wang
authors.forename: Zhang-Xin
authors.initials: ZX
authors.lastname: Zeng
authors.forename: Jian-Ming
authors.initials: JM
authors.lastname: Tan
mesh_terms: D000328:Adult; D015331:Cohort Studies; D005260:Female; D006084:Graft Rejection / Q000175:diagnosis*; D006801:Humans; D007165:Immunosuppression Therapy; D017730:Ki-1 Antigen / Q000097:blood*; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D015166:Monitoring, Immunologic; D011379:Prognosis; D012189:Retrospective Studies
chemical_list: D017730:Ki-1 Antigen