Endometrial stromal sarcoma with smooth muscle and glandular differentiation of the feline uterus.
The intra-abdominal tumor developing in the uterus and lung of a domestic Shorthair cat was examined histopathologically and immunohistochemically. The tumor showed a proliferation of both endometrial stromal and smooth muscle cells accompanied by prominent vasculature. There were well-differentiated endometrial glands, and tubuli made up a monolayer of eosinophilic cuboidal epithelium. Immunohistochemically, the spindle-shaped cells and half of the stromal-like cells reacted to caldesmon and desmin antibodies. The neoplastic epithelium expressed AE1/AE3 cytokeratin. Feline endometrial stromal tumor has, to the best of our knowledge, not been reported previously and has smooth muscle and glandular components that are a unique variant to the human counterpart.
Sato
T
T
Laboratory of Veterinary Pathology, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa, Kanagawa 252-8510, Japan. t-sato@brs.nihon-u.ac.jp
Maeda
H
H
Suzuki
A
A
Shibuya
H
H
Sakata
A
A
Shirai
W
W
D000818:Animals; D002371:Cat Diseases / Q000473:pathology*; D002415:Cats; D005260:Female; D018203:Sarcoma, Endometrial Stromal / Q000473:pathology / Q000662:veterinary*; D014599:Uterus / Q000473:pathology*