Idiopathic hypereosinophilic syndrome with skull base involvement.
Idiopathic hypereosinophilic syndrome (HES) is a heterogeneous disorder characterized by prolonged eosinophilia without an identifiable cause, ultimately resulting in organ dysfunction. Three major types of neurologic involvement have been well defined in HES; however, to our knowledge, inflammatory pseudotumor (IPT) in association with HES has not been reported. We present a case of IPT of the skull base in a patient with HES that suggests that HES may result in an exaggerated immunologic or inflammatory response leading to the formation of IPT.
Battineni
M L
ML
Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
Galetta
S L
SL
Oh
J
J
Lango
M
M
Brooks
J J
JJ
Schuster
S J
SJ
Loevner
L A
LA
D004660:Encephalitis / Q000209:etiology / Q000276:immunology / Q000473:pathology; D005260:Female; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000150:complications* / Q000276:immunology; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D011559:Pseudotumor Cerebri / Q000209:etiology* / Q000276:immunology / Q000473:pathology*; D019291:Skull Base / Q000473:pathology*