title: Determination of pKa values of benzoxa-, benzothia- and benzoselena-zolinone derivatives by capillary electrophoresis. Comparison with potentiometric titration and spectrometric data.
abstract: Acidity constants of benzoxa-, benzothia- and benzoselena-zolinone derivatives were determined by capillary electrophoresis, potentiometry and spectrophotometry experiments. These three analytical techniques gave pK(a) results that were in good agreement. A convenient, accurate and precise method for the determination of pK(a) was developed to measure changes in acidity constants induced by heteroatom or 6-benzoyl substituted derivatives. pK(a) values were determined simultaneously for two compounds characterized by different electrophoretic mobility (micro(e)) and pK(a) value and in the presence of an analogous neutral marker.
authors.affiliation: Laboratoire de Chimie Analytique, EA 4034, Faculté des Sciences Pharmaceutiques et Biologiques, Université de LILLE 2, Lille Cedex, France.
authors.forename: C
authors.initials: C
authors.lastname: Foulon
authors.forename: N
authors.initials: N
authors.lastname: Duhal
authors.forename: B
authors.initials: B
authors.lastname: Lacroix-Callens
authors.forename: C
authors.initials: C
authors.lastname: Vaccher
authors.forename: J P
authors.initials: JP
authors.lastname: Bonte
authors.forename: J F
authors.initials: JF
authors.lastname: Goossens
mesh_terms: D000143:Acids / Q000737:chemistry; D000465:Algorithms; D052160:Benzothiazoles / Q000737:chemistry*; D001583:Benzoxazoles / Q000737:chemistry*; D002021:Buffers; D019075:Electrophoresis, Capillary; D006863:Hydrogen-Ion Concentration; D015394:Molecular Structure; D016566:Organoselenium Compounds / Q000737:chemistry*; D023303:Oxazolidinones / Q000737:chemistry*; D011199:Potentiometry; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000143:Acids; D052160:Benzothiazoles; D001583:Benzoxazoles; D002021:Buffers; D016566:Organoselenium Compounds; D023303:Oxazolidinones