Sperm selection by swim-up in terms of deoxyribonucleic acid fragmentation as measured by the sperm chromatin dispersion test is altered in heavy smokers.
Toxic habits and their relationship with male factor infertility have been a matter of investigation in recent years, and smoking is one of the most common lifestyle toxic exposures to harmful substances. The analysis of sperm deoxyribonucleic acid fragmentation after capacitation detected a detrimental effect produced by tobacco, and this deleterious effect alters the sperm swim-up selection process in smokers, although the molecular and cellular basis of this phenomenon remain to be elucidated.
Viloria
Thamara
T
Instituto Valenciano de Infertilidad, Valencia, Universidad de Valencia, Valencia, Spain. tviloria@ivi.es <tviloria@ivi.es>
Garrido
Nicolás
N
Fernández
José Luis
JL
Remohí
José
J
Pellicer
Antonio
A
Meseguer
Marcos
M
D000328:Adult; D002469:Cell Separation; D002843:Chromatin / Q000378:metabolism*; D053938:DNA Fragmentation; D005307:Fertilization in Vitro; D006801:Humans; D007248:Infertility, Male / Q000175:diagnosis* / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D025202:Molecular Diagnostic Techniques; D012907:Smoking / Q000009:adverse effects*; D013075:Sperm Capacitation; D053625:Sperm Retrieval; D013094:Spermatozoa / Q000166:cytology*
D002843:Chromatin