title: Why is fat so tasty? Chemical reception of fatty acid on the tongue.
abstract: Fatty foods are very palatable. Most mammals, including humans, prefer high-fat food to low-fat food. Neuropeptides and neurotransmitters, which are related to the hedonic or aversive response in the brain, are released after a basic tastant (i.e., sweet, sour, salty, bitter or umami) is accepted by the taste receptors in the taste bud cells. In addition, recent evidence suggests that dietary fat, especially free fatty acids, may be perceived chemically in taste bud cells as well as the basic tastant. Recently, it was suggested that long-chain fatty acids accepted into CD36/FAT, a long-chain fatty acid transporter, in circumvallate papillae of the tongue play an extremely important role in the palatability of dietary fat. In this review, we describe the studies on the reception of fatty acids in the oral cavity, and on the signal transmission from the oral cavity to the brain. We hypothesize that long-chain fatty acids are recognized on the tongue, and then neuropeptides and neurotransmitters such as beta-endorphin and dopamine are released in the brain. We suggest that this knowledge is one of the mechanisms of the palatability of dietary fat.
authors.affiliation: Laboratory of Nutrition Chemistry, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto 606-8502, Japan.
authors.forename: Takafumi
authors.initials: T
authors.lastname: Mizushige
authors.forename: Kazuo
authors.initials: K
authors.lastname: Inoue
authors.forename: Tohru
authors.initials: T
authors.lastname: Fushiki
mesh_terms: D000818:Animals; D001921:Brain / Q000502:physiology; D004041:Dietary Fats; D004594:Electrophysiology; D005227:Fatty Acids / Q000737:chemistry / Q000378:metabolism*; D005247:Feeding Behavior; D005518:Food Preferences; D006801:Humans; D011984:Sensory Receptor Cells / Q000502:physiology; D015398:Signal Transduction; D013649:Taste / Q000502:physiology*; D014059:Tongue / Q000378:metabolism / Q000502:physiology*
chemical_list: D004041:Dietary Fats; D005227:Fatty Acids