Accuracy of leukocyte alkaline phosphatase score to predict JAK2 V617F mutation.
Granulocyte activation parameters have been described in patients with myeloproliferative disorders (MPD). We have evaluated the accuracy of leukocyte alkaline phosphatase (LAP) score to predict JAK2 V617F mutation. LAP score was obtained using a cytochemical reaction in granulocytes of patients' peripheral blood with MPD.
Basquiera
Ana L
AL
Fassetta
Fernanda
F
Soria
Néstor
N
Barral
José Moreno
JM
Ricchi
Brenda
B
García
Juan J
JJ
D000328:Adult; D000368:Aged; D000469:Alkaline Phosphatase / Q000097:blood*; D019943:Amino Acid Substitution; D019540:Area Under Curve; D005260:Female; D006801:Humans; D053614:Janus Kinase 2 / Q000235:genetics*; D007962:Leukocytes / Q000201:enzymology*; D008297:Male; D008875:Middle Aged; D020125:Mutation, Missense; D009196:Myeloproliferative Disorders / Q000097:blood* / Q000201:enzymology; D018375:Neutrophil Activation; D017354:Point Mutation; D011237:Predictive Value of Tests; D016037:Single-Blind Method
C507924:JAK2 protein, human; D053614:Janus Kinase 2; D000469:Alkaline Phosphatase