[Persistent polyarticular synovitis after treatment with alendronate].
A 62-year-old, previously healthy woman diagnosed with post-menopausal osteoporosis received alendronate 70 mg/week. One week after the first dose, she developed polyarticular synovitis in the hands, feet and knees. We suspect this to be an adverse reaction to alendronate. At follow-up after 14 months, the patient still had residual synovitis, mainly in the hands and finger joints, despite continued low-dose prednisolone therapy. Two additional cases of synovitis associated with bisphosphonate therapy have been reported in the literature. The pathophysiology behind this phenomenon is unknown.
Frederiksen
Louise
L
Odense Universitetshospital, Endokrinologisk Afdeling M. louisefrederiksen@tdcadsl.dk
Junker
Peter
P
Brixen
Kim T
KT
D019386:Alendronate / Q000009:adverse effects*; D001168:Arthritis / Q000139:chemically induced*; D050071:Bone Density Conservation Agents / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000188:drug therapy; D013585:Synovitis / Q000139:chemically induced*
D050071:Bone Density Conservation Agents; D019386:Alendronate