title: AMPK mediates autophagy during myocardial ischemia in vivo.
abstract: We have recently shown that autophagy is induced by ischemia and reperfusion in the mouse heart in vivo. Ischemia stimulates autophagy through an AMP activated protein kinase (AMPK)-dependent mechanism, whereas reperfusion after ischemia stimulates autophagy through a Beclin 1-dependent, but AMPK-independent, mechanism. Autophagy plays distinct roles during ischemia and reperfusion: autophagy may be protective during ischemia, whereas it may be detrimental during reperfusion. We will discuss the role of AMPK in mediating autophagy during myocardial ischemia in vivo.
authors.affiliation: Cardiovascular Research Institute, Department of Cell Biology and MolecularMedicine, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey 07103, USA.
authors.forename: Hiromitsu
authors.initials: H
authors.lastname: Takagi
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Matsui
authors.forename: Shinichi
authors.initials: S
authors.lastname: Hirotani
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Sakoda
authors.forename: Tomoichiro
authors.initials: T
authors.lastname: Asano
authors.forename: Junichi
authors.initials: J
authors.lastname: Sadoshima
mesh_terms: D055372:AMP-Activated Protein Kinases; D000818:Animals; D051017:Apoptosis Regulatory Proteins; D001343:Autophagy / Q000502:physiology*; D000071186:Beclin-1; D002478:Cells, Cultured; D004789:Enzyme Activation; D051379:Mice; D008954:Models, Biological; D009097:Multienzyme Complexes / Q000378:metabolism*; D017202:Myocardial Ischemia / Q000378:metabolism*; D015425:Myocardial Reperfusion; D032383:Myocytes, Cardiac / Q000166:cytology / Q000378:metabolism; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism
chemical_list: D051017:Apoptosis Regulatory Proteins; D000071186:Beclin-1; C115010:Becn1 protein, mouse; D009097:Multienzyme Complexes; D011506:Proteins; D017346:Protein Serine-Threonine Kinases; D055372:AMP-Activated Protein Kinases