title: Theories of blood coagulation.
abstract: Although the concept of the coagulation cascade represented a significant advance in the understanding of coagulation and served for many years as a useful model, more recent clinical and experimental observations demonstrate that the cascade/waterfall hypothesis does not fully and completely reflect the events of hemostasis in vivo. The goal of this article is to review the evolution of the theories of coagulation and their proposed models to serve as a tool when reviewing the research and practice literature that was published in the context of these different theories over time.
authors.affiliation: Division of Hematology at Children's Hospital and Research Center Oakland, Oakland, California 94609-1809, USA. jriddel@mail.cho.org
authors.forename: James P
authors.initials: JP
authors.lastname: Riddel
authors.forename: Bradley E
authors.initials: BE
authors.lastname: Aouizerat
authors.forename: Christine
authors.initials: C
authors.lastname: Miaskowski
authors.forename: David P
authors.initials: DP
authors.lastname: Lillicrap
mesh_terms: D001777:Blood Coagulation / Q000502:physiology*; D025861:Blood Coagulation Disorders, Inherited / Q000097:blood / Q000235:genetics; D001779:Blood Coagulation Factors / Q000502:physiology*; D005337:Fibrin / Q000502:physiology; D005340:Fibrinogen / Q000502:physiology; D006487:Hemostasis / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D011516:Prothrombin / Q000502:physiology; D013917:Thrombin / Q000502:physiology
chemical_list: D001779:Blood Coagulation Factors; D011516:Prothrombin; D005337:Fibrin; D005340:Fibrinogen; D013917:Thrombin