T-cell depletion prevents from bronchiolitis obliterans and bronchiolitis obliterans with organizing pneumonia after allogeneic hematopoietic stem cell transplantation with related donors.
Bronchiolitis obliterans (BO) and bronchiolitis obliterans organizing pneumonia (BOOP) are late-onset non-infectious pulmonary complications (LONIPCs) following allogeneic hematopoietic stem cell transplantation (HSCT). In the present study 10 of 197 conventionally prepared stem cell recipients developed BOOP after 365 days and 6 patients developed BO 333 days post-transplant. No BOOP or BO was diagnosed following T-cell depletion (p<0.05). Chronic GVHD was ascertained in all BOOP patients and appeared significantly (p<0,001) more frequent in the conventional transplant group. The data confirm a strong association between T-cell activity, chronic GVHD, BO and BOOP and point out the impact of T lymphocytes in the pathomechanism of BOOP.
Ditschkowski
Markus
M
Department of bone marrow transplantation, University Hospital of Essen, Essen, Germany. markus.ditschkowski@uni-essen.de
Elmaagacli
Ahmet H
AH
Trenschel
Rudolf
R
Peceny
Rudolf
R
Koldehoff
Michael
M
Schulte
Claudia
C
Beelen
Dietrich W
DW
D000328:Adult; D000368:Aged; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D001989:Bronchiolitis Obliterans / Q000209:etiology / Q000235:genetics / Q000276:immunology / Q000517:prevention & control*; D018549:Cryptogenic Organizing Pneumonia / Q000209:etiology / Q000235:genetics / Q000276:immunology / Q000517:prevention & control*; D005260:Female; D006086:Graft vs Host Disease / Q000209:etiology / Q000517:prevention & control; D006801:Humans; D053208:Kaplan-Meier Estimate; D008212:Lymphocyte Depletion / Q000706:statistics & numerical data; D017710:Lymphocyte Transfusion; D008297:Male; D008875:Middle Aged; D053473:Nod2 Signaling Adaptor Protein / Q000235:genetics; D036102:Peripheral Blood Stem Cell Transplantation / Q000009:adverse effects*; D011183:Postoperative Complications / Q000209:etiology / Q000401:mortality / Q000517:prevention & control*; D016016:Proportional Hazards Models; D012131:Respiratory Insufficiency / Q000401:mortality; D012189:Retrospective Studies; D012737:Sex Factors; D013601:T-Lymphocytes / Q000276:immunology / Q000637:transplantation; D014019:Tissue Donors; D051197:Toll-Like Receptor 4 / Q000235:genetics; D019172:Transplantation Conditioning / Q000009:adverse effects*; D014184:Transplantation, Homologous
C429018:NOD2 protein, human; D053473:Nod2 Signaling Adaptor Protein; C495345:TLR4 protein, human; D051197:Toll-Like Receptor 4