title: Binding of ceftobiprole and comparators to the penicillin-binding proteins of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae.
abstract: Ceftobiprole exhibited tight binding to PBP2a in methicillin-resistant Staphylococcus aureus, PBP2x in penicillin-resistant Streptococcus pneumoniae, and PBP3 and other essential penicillin-binding proteins in methicillin-susceptible S. aureus, Escherichia coli, and Pseudomonas aeruginosa. Ceftobiprole also bound well to PBP2 in the latter organisms, contributing to the broad-spectrum antibacterial activity against gram-negative and gram-positive bacteria.
authors.affiliation: Johnson & Johnson Pharmaceutical Research and Development, LLC, Room B225, 1000 Route 202, Raritan, NJ 08869, USA. tdavies@prdus.jnj.com
authors.forename: Todd A
authors.initials: TA
authors.lastname: Davies
authors.forename: Malcolm G P
authors.initials: MG
authors.lastname: Page
authors.forename: Wenchi
authors.initials: W
authors.lastname: Shang
authors.forename: Ted
authors.initials: T
authors.lastname: Andrew
authors.forename: Malgosia
authors.initials: M
authors.lastname: Kania
authors.forename: Karen
authors.initials: K
authors.lastname: Bush
mesh_terms: D001426:Bacterial Proteins / Q000378:metabolism*; D002511:Cephalosporins / Q000378:metabolism*; D029968:Escherichia coli Proteins / Q000378:metabolism*; D006090:Gram-Negative Bacteria / Q000378:metabolism*; D020128:Inhibitory Concentration 50; D008826:Microbial Sensitivity Tests; D046915:Penicillin-Binding Proteins / Q000378:metabolism*; D011550:Pseudomonas aeruginosa / Q000737:chemistry / Q000378:metabolism; D013211:Staphylococcus aureus / Q000737:chemistry / Q000378:metabolism; D013296:Streptococcus pneumoniae / Q000737:chemistry / Q000378:metabolism
chemical_list: D001426:Bacterial Proteins; D002511:Cephalosporins; D029968:Escherichia coli Proteins; D046915:Penicillin-Binding Proteins; C443755:ceftobiprole