title: Chemical tools from biology-oriented synthesis.
abstract: Lessmann et al. present a chiral natural-product-derived library of alpha,beta-unsaturated delta-lactones obtained through stereoselective synthesis on a solid support [1]. Phenotypic screening of this compound collection provided new modulators of cell cycle progression and of viral cell entry with high hit rates.
authors.affiliation: Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology (ETH) Zürich, HCI H 405, Wolfgang-Pauli-Strasse 10, 8093 Zurich, Switzerland. karl-heinz.altmann@pharma.ethz.ch
authors.forename: Karl-Heinz
authors.initials: KH
authors.lastname: Altmann
mesh_terms: D000818:Animals; D001665:Binding Sites; D001688:Biological Products / Q000737:chemistry* / Q000378:metabolism; D002453:Cell Cycle / Q000187:drug effects*; D015195:Drug Design; D006801:Humans; D007783:Lactones / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D008968:Molecular Conformation; D011485:Protein Binding; D013237:Stereoisomerism; D053586:Virus Internalization / Q000187:drug effects*
chemical_list: D001688:Biological Products; D007783:Lactones