Leishmanicidal evaluation of extracts from native plants of the Yucatan peninsula.
Methanol extracts were prepared from different parts of 18 plants collected in the Yucatan peninsula and evaluated in an in vitro bioassay for leishmanicidal activity against Leishmania mexicana promastigotes. The ten most potent plant extracts (IC(50)<50 microg/ml) were Aphelandra scabra leaves, Byrsonima bucidaefolia bark, Byrsonima crassifolia bark, Clusia flava leaves, Cupania dentata bark, Diphysa carthagenensis leaves, Dorstenia contrajerva whole plant, Milleria quinqueflora roots, Tridax procumbens whole plant, and Vitex gaumeri bark.
Peraza-Sánchez
S R
SR
Centro de Investigación Científica de Yucatán, Calle 41 #130, Col. Chuburná de Hidalgo, Merida, Yucatan, 97200 (CICY), Mexico. speraza@cicy.mx
Cen-Pacheco
F
F
Noh-Chimal
A
A
May-Pat
F
F
Simá-Polanco
P
P
Dumonteil
E
E
García-Miss
M R
MR
Mut-Martín
M
M
D000818:Animals; D000981:Antiprotozoal Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D020128:Inhibitory Concentration 50; D007894:Leishmania mexicana / Q000187:drug effects*; D016773:Leishmaniasis, Cutaneous / Q000188:drug therapy; D008519:Medicine, Traditional; D008800:Mexico; D021261:Parasitic Sensitivity Tests; D008517:Phytotherapy; D024301:Plant Bark; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves; D010946:Plants, Medicinal
D000981:Antiprotozoal Agents; D010936:Plant Extracts