title: Invasive group B streptococcal infection in infants, Malawi.
abstract: Group B streptococci (GBS) are a recently identified cause of neonatal sepsis in Malawi. In Queen Elizabeth Central Hospital, Blantyre, Malawi, during May 2004-June 2005, GBS were isolated from routine blood and cerebrospinal fluid cultures from 57 infants. The incidence of early (EOD) and late onset (LOD) invasive GBS disease was 0.92 and 0.89 cases per 1,000 live births, respectively. Sepsis (52%) was the most common manifestation of EOD; meningitis (43%) and sepsis (36%) were the principal manifestations of LOD. The case-fatality rate was 33% overall (38% EOD, 29% LOD). Serotypes Ia and III were responsible for 77% of disease. All isolates were susceptible to penicillin, but 21% were resistant to erythromycin. The rate and manifestations of neonatal GBS disease in Malawi are similar to those in industrialized countries, but the case-fatality rate is higher than in industrialized countries. Effective locally relevant prevention strategies are needed.
authors.affiliation: Malawi-Liverpool-Wellcome Trust Programme of Clinical Tropical Research, Blantyre, Malawi. kgray@africa-online.net
authors.forename: Katherine J
authors.initials: KJ
authors.lastname: Gray
authors.forename: Sally L
authors.initials: SL
authors.lastname: Bennett
authors.forename: Neil
authors.initials: N
authors.lastname: French
authors.forename: Amos J
authors.initials: AJ
authors.lastname: Phiri
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Graham
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008295:Malawi / Q000453:epidemiology; D008297:Male; D008581:Meningitis / Q000453:epidemiology / Q000382:microbiology; D018410:Pneumonia, Bacterial / Q000453:epidemiology / Q000382:microbiology; D012307:Risk Factors; D018805:Sepsis / Q000453:epidemiology / Q000382:microbiology; D013290:Streptococcal Infections / Q000453:epidemiology*; D013292:Streptococcus agalactiae / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents