The long pentraxin 3 in cardiac surgery: distinct responses in "on-pump" and "off-pump" patients.
OBJECTIVE
Pentraxin 3 (PTX3) is a newly identified acute phase reactant with non-redundant functions in innate immunity. The purpose of this study was to assess the kinetics of release of PTX3 in cardiac surgical patients, operated on either with or without the use of cardiopulmonary bypass (CPB).


METHODS
Thirty-four patients, seventeen in each group, were randomly assigned to CABG surgery performed either with ("on-pump") or without ("off-pump") CPB. Blood samples were collected both during and after the operation up to the 7(th) day.


RESULTS
In patients operated on with the use of CPB, PTX3 levels increased throughout the operation. Compared to baseline levels the highest PTX3 value (p<0.000) was attained on the 1(st) postoperative day in both "on-pump" and "off-pump" patients. In contrast to CPB patients, however, PTX3 levels in the latter group declined slowly, remaining elevated as long as the 3(rd) postoperative day (p<0.042).


CONCLUSIONS
Operations performed with the use of CPB are associated with a more pronounced release of PTX3 immediately after operation.
Kunes
Pavel
P
Department of Cardiac Surgery, Charles University in Prague, University Hospital and Faculty of Medicine in Hradec Králové, Czech Republic.
Lonsky
Vladimir
V
Mandak
Jiri
J
Kolackova
Martina
M
Andrys
Ctirad
C
Kudlova
Manuela
M
Krejsek
Jan
J
D000368:Aged; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism*; D002315:Cardiopulmonary Bypass; D001026:Coronary Artery Bypass; D047549:Coronary Artery Bypass, Off-Pump; D005260:Female; D006801:Humans; D016753:Interleukin-10 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D000683:Serum Amyloid P-Component / Q000378:metabolism*; D016896:Treatment Outcome; D000099153:Pentraxins
D015415:Biomarkers; D002097:C-Reactive Protein; D016753:Interleukin-10; D015850:Interleukin-6; D000683:Serum Amyloid P-Component; D000099153:Pentraxins; C508609:IL10 protein, human; C508600:IL6 protein, human