title: Basilar artery stent angioplasty for symptomatic intracranial athero-occlusive disease: complications and late midterm clinical outcomes.
abstract: OBJECTIVE
  After an initial series of basilar artery stent angioplasty indicated a high technical success rate and minimal morbidity, subsequent reports suggested significant procedural risks. We retrospectively reviewed our experience with basilar artery stent placement to assess complications and clinical outcomes.
  
  
  METHODS
  Ten consecutive patients with symptomatic intracranial athero-occlusive disease underwent stent placement of the basilar artery at our institution (1999-2003). We collected clinical data by chart review and determined outcomes (modified Rankin Scale [mRS]) by telephone interview. Angiographic data were analyzed by 2 blinded investigators. Clinical and angiographic variables were tested for correlation with outcome and complications using the Pearson correlation test.
  
  
  RESULTS
  Of 10 patients (mean follow-up time, 31 months), 4 patients suffered 6 ischemic complications that were immediate in 1, early delayed (<2 weeks) in 4, and late delayed (>2 weeks) in 1. Complications included basilar artery rupture in 1 patient, access site complications in 1 patient, and other non-neurologic complications in 5. Symptomatic restenosis occurred in 1 patient. Outcomes (mRS) were excellent (0-2) in 5 patients, good (3) in 4, and poor (4-6) in 1 patient, who died. Ischemic complications were associated with lesion lumen <or=0.5 mm and lesion angulation >45 degrees (P<.05). Less favorable clinical outcomes were associated with few ischemic complications and the presence of fewer than 2 patent vertebral arteries (P<.05).
  
  
  CONCLUSIONS
  Despite a significant incidence of ischemic and nonischemic complications after basilar artery stent placement, most patients in this small series achieved freedom from vertebrobasilar ischemia and good to excellent clinical outcomes at late midterm follow-up (12-46 months). Ischemic complications usually had an early delayed presentation and procedural risks correlated with lesion characteristics.
authors.affiliation: Department of Radiology, The Neuroscience Institute, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267-0515, USA. editor@mayfieldclinic.com
authors.forename: T A
authors.initials: TA
authors.lastname: Abruzzo
authors.forename: F C
authors.initials: FC
authors.lastname: Tong
authors.forename: A S M
authors.initials: AS
authors.lastname: Waldrop
authors.forename: M J
authors.initials: MJ
authors.lastname: Workman
authors.forename: H J
authors.initials: HJ
authors.lastname: Cloft
authors.forename: J E
authors.initials: JE
authors.lastname: Dion
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D017542:Aneurysm, Ruptured / Q000453:epidemiology / Q000601:surgery; D017130:Angioplasty / Q000379:methods*; D002545:Brain Ischemia / Q000453:epidemiology / Q000517:prevention & control; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009017:Morbidity; D011183:Postoperative Complications / Q000453:epidemiology* / Q000517:prevention & control; D012189:Retrospective Studies; D012307:Risk Factors; D015607:Stents; D016896:Treatment Outcome; D014715:Vertebrobasilar Insufficiency / Q000453:epidemiology* / Q000601:surgery*
chemical_list: D005343:Fibrinolytic Agents