Manganese: recent advances in understanding its transport and neurotoxicity.
The present review is based on presentations from the meeting of the Society of Toxicology in San Diego, CA (March 2006). It addresses recent developments in the understanding of the transport of manganese (Mn) into the central nervous system (CNS), as well as brain imaging and neurocognitive studies in non-human primates aimed at improving our understanding of the mechanisms of Mn neurotoxicity. Finally, we discuss potential therapeutic modalities for treating Mn intoxication in humans.
Aschner
Michael
M
Department of Pediatrics, and The Kennedy Center for Research on Human Development, Vanderbilt University, School of Medicine, Nashville, TN 37232-2495, USA. michael.aschner@vanderbilt.edu
Guilarte
Tomás R
TR
Schneider
Jay S
JS
Zheng
Wei
W
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001692:Biological Transport; D001921:Brain / Q000000981:diagnostic imaging / Q000187:drug effects; D008345:Manganese / Q000493:pharmacokinetics* / Q000633:toxicity*; D049268:Positron-Emission Tomography; D011323:Primates
D008345:Manganese