[Dementia with Lewy bodies. Clinical improvement under treatment with an acetylcholinesterase inhibitor].
Dementia with Lewy Bodies (DLB) is the second most common form of dementia in the elderly. Core features of the DLB are fluctuating cognitive symptoms, visual hallucinations and spontaneous parkinsonism. The clinical diagnostic criteria are very useful in the differentiation between DLB and Alzheimer's disease. The deficits in cholinergic neurotransmission are pronounced and associated with cognitive and psychotic symptoms. An 83 years old patient with DLB showed well formed recurrent visual hallucinations and fluctuating cognition and attention. There was no response to treatment with atypical neuroleptics. The patient responded within few days to treatment with Donepezil. Both cognitive and behavioural symptoms were improved significantly.
Omerovic
M
M
Klinik und Poliklinik für Psychiatrie und Psychotherapie der Ludwig-Maximilians-Universität München, Nussbaumstrasse 7, 80336, München.
Teipel
S J
SJ
Hampel
T
T
D000368:Aged; D002800:Cholinesterase Inhibitors / Q000627:therapeutic use; D000077265:Donepezil; D006212:Hallucinations / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D007189:Indans / Q000627:therapeutic use*; D020961:Lewy Body Disease / Q000150:complications / Q000188:drug therapy*; D008297:Male; D001523:Mental Disorders / Q000150:complications / Q000188:drug therapy*; D010880:Piperidines / Q000627:therapeutic use*; D016896:Treatment Outcome
D002800:Cholinesterase Inhibitors; D007189:Indans; D010880:Piperidines; D000077265:Donepezil