A potential role of EMMPRIN by regulating ECM degradation in periodontitis.
Periodontitis are characterized by the destruction of the extracellular matrix (ECM) of periodontal tissues. Matrix metalloproteinases (MMPs) play an important role in the degradation of ECM. But until now, it is not clear about the regulation of MMPs expression level in periodontitis. EMMPRIN is a 58 kDa, highly glycosylated, transmembrane molecule belonging to the immunoglobin superfamily, which interacts with fibroblasts to stimulate the expression of MMPs. It is logical to postulate that EMMPRIN may play a critical role in the regulation of MMPs participating the destruction of periodontal ECM in periodontitis. The hypothesis will provide the brand-new direction that we may prevent and treat the periodontitis by regulating the expression of EMMPRIN in host aspect.
Cao
ZhengGuo
Z
Key Laboratory for Oral Biomedical Engineering of Ministry of Education, School and Hospital of Stomatology, Wuhan University, Hongshan District, Wuhan 430079, People's Republic of China.
Xiang
JunBo
J
Li
ChengZhang
C
D000818:Animals; D051926:Basigin / Q000276:immunology*; D005109:Extracellular Matrix / Q000276:immunology* / Q000473:pathology*; D006706:Homeostasis / Q000276:immunology; D006801:Humans; D018448:Models, Immunological; D010518:Periodontitis / Q000276:immunology* / Q000473:pathology*; D015398:Signal Transduction / Q000276:immunology
D051926:Basigin