[Evaluation of the effect of inhaled glucocorticosteroids by morning cortisolemia].
The authors study the effect on adrenal function of a small dose of inhaled steroids in children with asthma. The study group consisting in 61 children treated with inhaled steroids (38 children treated with beclomethasone dipropionate and 23 treated with fluticasone propionate) who were compared with 17 controls (children with asthma treated with nonsteroidal therapy). In the study group, after 12 months of therapy morning cortisolemia was lower as compared with the values before the treatment. In children treated with beclomethasone the morning cortisol before therapy was 217.6 +/- 76.4 nmol/L and after therapy of 171.5 +/- 52 nmol/L (p < 0.077). In children treated with fluticasone initial cortisol was of 210.8 +/- 19.5 nmol/L and after treatment of 175.2 +/- 30.9 nmol/L (p < 0.027).
Cherecheş
Panţa Paraschiva
PP
U.M.F. "Iuliu Haţieganu", Clinica Pediatrie III, Cluj-Napoca. pusachereches@umfcluj.ro
Marshall
D Mirela
DM
Ichim
Gabriela
G
Crişan
Marinela
M
Nanulescu
M V
MV
D000280:Administration, Inhalation; D000293:Adolescent; D000730:Androstadienes / Q000008:administration & dosage; D018927:Anti-Asthmatic Agents / Q000008:administration & dosage* / Q000097:blood; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage* / Q000097:blood; D001249:Asthma / Q000097:blood* / Q000188:drug therapy*; D001507:Beclomethasone / Q000008:administration & dosage; D001993:Bronchodilator Agents / Q000008:administration & dosage; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D002940:Circadian Rhythm; D004359:Drug Therapy, Combination; D005260:Female; D000068298:Fluticasone; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D008137:Longitudinal Studies; D008297:Male; D011446:Prospective Studies; D012720:Severity of Illness Index
D000730:Androstadienes; D018927:Anti-Asthmatic Agents; D000893:Anti-Inflammatory Agents; D001993:Bronchodilator Agents; D005938:Glucocorticoids; D000068298:Fluticasone; D001507:Beclomethasone; D006854:Hydrocortisone