DITOP: drug-induced toxicity related protein database.
BACKGROUND
Drug-induced toxicity related proteins (DITRPs) are proteins that mediate adverse drug reactions (ADRs) or toxicities through their binding to drugs or reactive metabolites. Collection of these proteins facilitates better understanding of the molecular mechanisms of drug-induced toxicity and the rational drug discovery. Drug-induced toxicity related protein database (DITOP) is such a database that is intending to provide comprehensive information of DITRPs. Currently, DITOP contains 1501 records, covering 618 distinct literature-reported DITRPs, 529 drugs/ligands and 418 distinct toxicity terms. These proteins were confirmed experimentally to interact with drugs or their reactive metabolites, thus directly or indirectly cause adverse effects or toxicities. Five major types of drug-induced toxicities or ADRs are included in DITOP, which are the idiosyncratic adverse drug reactions, the dose-dependent toxicities, the drug-drug interactions, the immune-mediated adverse drug effects (IMADEs) and the toxicities caused by genetic susceptibility. Molecular mechanisms underlying the toxicity and cross-links to related resources are also provided while available. Moreover, a series of user-friendly interfaces were designed for flexible retrieval of DITRPs-related information. The DITOP can be accessed freely at http://bioinf.xmu.edu.cn/databases/ADR/index.html.


BACKGROUND
Supplementary data are available at Bioinformatics online.
Zhang
Jing-Xian
JX
Key Laboratory for Cell Biology & Tumor Cell Engineering, the Ministry of Education of China, School of Life Sciences, Xiamen University, Xiamen 361005, FuJian, PR China.
Huang
Wei-Juan
WJ
Zeng
Jing-Hua
JH
Huang
Wen-Hui
WH
Wang
Yi
Y
Zhao
Rui
R
Han
Bu-Cong
BC
Liu
Qing-Feng
QF
Chen
Yu-Zong
YZ
Ji
Zhi-Liang
ZL
D016907:Adverse Drug Reaction Reporting Systems; D030562:Databases, Protein; D064420:Drug-Related Side Effects and Adverse Reactions; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D011506:Proteins / Q000737:chemistry*
D004364:Pharmaceutical Preparations; D011506:Proteins