B cells: no longer the nondominant arm of multiple sclerosis.
The role B cells and humoral immunity play in multiple sclerosis (MS) is continually evolving. Recent discoveries include advances in lesion classification, identification of B cell clonal expansion in the central nervous system with evidence of antigen targeting, identification of chemokines in MS lesions, and expansion of information on the roles of autoantibodies and complement. Strong indications are accumulating that a greater degree of humoral dysfunction may lead to worsened long-term prognosis in MS. Effects of established MS treatments on B cells and their products have been further defined. Treatments that specifically target B cells are being implemented and hold promise.
Klawiter
Eric C
EC
Department of Neurology, Washington University School of Medicine, Box 8111, 660 S. Euclid Avenue, Saint Louis, MO 63110, USA. klawitere@neuro.wustl.edu
Cross
Anne H
AH
D000917:Antibody Formation / Q000502:physiology*; D051401:Aquaporin 4 / Q000276:immunology; D001323:Autoantibodies / Q000276:immunology; D001402:B-Lymphocytes / Q000187:drug effects / Q000276:immunology* / Q000502:physiology; D002555:Cerebrospinal Fluid / Q000737:chemistry / Q000276:immunology; D018925:Chemokines / Q000276:immunology; D003165:Complement System Proteins / Q000276:immunology; D018450:Disease Progression; D004777:Environment; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology; D007136:Immunoglobulins / Q000276:immunology; D009103:Multiple Sclerosis / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology / Q000473:pathology
C496030:AQP4 protein, human; D051401:Aquaporin 4; D001323:Autoantibodies; D018925:Chemokines; D007136:Immunoglobulins; D003165:Complement System Proteins