[Involvement of the primitive cardiac segments in the normal cardiogenesis. Its importance in the pediatric cardiology].
The ample development of diagnostic echocardiography in pediatric cardiology has demanded precise knowledge of the abnormal anatomy of hearts that present congenital cardiac diseases. As a result, the information on morphologic and molecular aspects of cardiac embryogenesis has become fundamental to understand the anomalous anatomy of the malformed hearts. Based on these facts, in this paper we reviewed normal cardiogenesis, integrating the new information obtained experimentally in the chick embryo and from classic descriptive knowledge in humans. The age at which each cardiac segment appears is specified. At the same time, the changes in shape, relationships and position of these cardiac segments are detailed. Some implications of this process in the production of congenital cardiac defects and the importance of some specific genes are also discussed. This information is useful in the diagnosis of congenital cardiac diseases, as well as in discussing their embryogenesis. It is also beneficial in studying the possible mechanisms and genes implicated in normal morphogenesis of cardiac chambers, septa and valves. All this knowledge is important to plan strategies to avoid the production of this type of congenital pathologies.
Salazar García
Marcela
M
Departamento de Biologia del Desarrollo y Teratogénesis Experimental, Hospital Infantil de México Federico Gómez.
Sánchez Gómez
Concepción
C
Contreras Ramos
Alejandra
A
Carrillo Avalos
Blanca A
BA
Revilla Monsalve
Ma Cristina
MC
Palomino Garibay
Miguel Angel
MA
D000818:Animals; D002642:Chick Embryo; D002648:Child; D005865:Gestational Age; D006321:Heart / Q000196:embryology*; D006330:Heart Defects, Congenital / Q000175:diagnosis / Q000196:embryology; D006346:Heart Septum / Q000196:embryology; D006351:Heart Valves / Q000196:embryology; D006352:Heart Ventricles / Q000196:embryology; D006801:Humans; D009024:Morphogenesis; D038081:Organogenesis; D051381:Rats