title: Treatment and long-term follow-up of extrahepatic biliary obstruction with bilirubin cholelithiasis in a Somali cat with pyruvate kinase deficiency.
abstract: A 2-year-old female neutered Somali cat was presented with vomiting and acute onset jaundice 1 year after diagnosis of pyruvate kinase (PK) deficiency. Diagnostic investigations revealed a moderate regenerative haemolytic anaemia, severe hyperbilirubinaemia and elevated liver enzymes. Ultrasonography revealed marked distension of the gall bladder and common bile duct (CBD), consistent with extrahepatic biliary obstruction (EHBO). At cholecystotomy, the gall bladder contained purulent material, and two obstructive choleliths were removed from the CBD by choledochotomy. The cat recovered from surgery uneventfully, and serum liver enzymes and bilirubin normalised within 10 days. Postoperative treatment consisted of cephalexin, metronidazole and ursodeoxycholic acid (UDCA). Bacterial culture of the gall bladder contents yielded a pure growth of an Actinomyces species. Cholelith analysis revealed that they consisted of 100% bilirubin. Antibiotic treatment was stopped 4 weeks after surgery but UDCA was continued indefinitely. The cat remains clinically well with no recurrence of cholelithiasis 20 months after initial presentation. This is the first report of successful treatment and long-term follow-up of a cat with EHBO due to bilirubin cholelithiasis in association with PK deficiency-induced chronic haemolysis.
authors.affiliation: Department of Clinical Veterinary Science, Division of Companion Animals, University of Bristol, Langford, Bristol BS405DU, UK. a.m.harvey@bristol.ac.uk
authors.forename: Andrea M
authors.initials: AM
authors.lastname: Harvey
authors.forename: Peter E
authors.initials: PE
authors.lastname: Holt
authors.forename: Frances J
authors.initials: FJ
authors.lastname: Barr
authors.forename: Francesca
authors.initials: F
authors.lastname: Rizzo
authors.forename: Séverine
authors.initials: S
authors.lastname: Tasker
mesh_terms: D000818:Animals; D002371:Cat Diseases / Q000097:blood / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D002415:Cats; D001651:Cholestasis, Extrahepatic / Q000150:complications / Q000175:diagnosis / Q000628:therapy / Q000662:veterinary*; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006932:Hyperbilirubinemia / Q000150:complications / Q000175:diagnosis / Q000628:therapy / Q000662:veterinary*; D010375:Pedigree; D011770:Pyruvate Kinase / Q000097:blood / Q000172:deficiency*; D014463:Ultrasonography
chemical_list: D011770:Pyruvate Kinase