Effectiveness of intrauterine insemination in subfertile couples with an isolated cervical factor: a randomized clinical trial.
After randomization of subfertile couples with an isolated cervical factor to intrauterine insemination for 6 months or expectant management for 6 months, 26 women (51%) vs. 16 women (33%) conceived, respectively. Of these pregnancies, 22 (43%) vs. 13 (27%) were ongoing (relative risk, 1.6; 95% confidence interval, 0.91 to 2.8). There was one multiple pregnancy in the group that was allocated to intrauterine insemination. This trial suggests a beneficial effect of IUI in couples with an isolated cervical factor.
Steures
Pieternel
P
Department of Obstetrics and Gynecology, Vrije Universiteit Medical Center, Amsterdam, the Netherlands. pn.steures@amc.uva.nl
van der Steeg
Jan Willem
JW
Hompes
Peter G A
PG
Bossuyt
Patrick M M
PM
Habbema
J Dik F
JD
Eijkemans
Marinus J C
MJ
Schöls
Willem A
WA
Burggraaff
Jan M
JM
van der Veen
Fulco
F
Mol
Ben W J
BW
D000328:Adult; D000465:Algorithms; D002584:Cervix Uteri / Q000473:pathology; D005191:Family Characteristics; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000175:diagnosis / Q000628:therapy*; D007315:Insemination, Artificial / Q000379:methods*; D008297:Male; D011379:Prognosis; D016896:Treatment Outcome