Adjunct duties for karyopherins: regulating septin sumoylation.
Karyopherins are shuttling transport receptors regulated by the small GTPase Ran, which move cargo between the nucleus and cytoplasm by passing through the nuclear pore complexes. A recent paper in Journal of Cell Biology (Makhnevych et al., 2007) highlights an additional role for karyopherins during mitosis, in regulating the sumoylation status of the septin rings.
Panse
Vikram Govind
VG
Institute of Biochemistry (IBC), Schafmattstrasse 18, ETH Zürich, CH-8093 Zürich, Switzerland.
Hurt
Ed
E
D003546:Cysteine Endopeptidases / Q000378:metabolism; D003598:Cytoskeletal Proteins / Q000378:metabolism*; D028884:Karyopherins / Q000378:metabolism*; D022022:Nuclear Pore / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000201:enzymology / Q000378:metabolism*; D025841:Small Ubiquitin-Related Modifier Proteins / Q000378:metabolism*
D003598:Cytoskeletal Proteins; D028884:Karyopherins; D025841:Small Ubiquitin-Related Modifier Proteins; D003546:Cysteine Endopeptidases; C118083:Ulp1 protease