What is a schizophrenic mouse?
In this issue of Neuron, Clapcote et al. examine mice containing missense mutations of the DISC1 gene, a locus associated with major mental illness in at least one large Scottish family. Genetic manipulation of mouse homologs of genes implicated in the etiology of psychiatric disorders is a promising avenue of research, but also one that is fraught with interpretative difficulties.
Low
Nancy C
NC
Department of Psychiatry, McGill University, 1033 Pine Avenue West, Montreal, Quebec, H3A 1A1, Canada.
Hardy
John
J
D000818:Animals; D004195:Disease Models, Animal; D051379:Mice; D020125:Mutation, Missense / Q000235:genetics; D009419:Nerve Tissue Proteins / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics / Q000473:pathology / Q000503:physiopathology
C498794:Disc1 protein, mouse; D009419:Nerve Tissue Proteins