title: Risk factors for Barrett's oesophagus and oesophageal adenocarcinoma: results from the FINBAR study.
abstract: OBJECTIVE
  To investigate risk factors associated with Barrett's oesophagus and oesophageal adenocarcinoma.
  
  
  METHODS
  This all-Ireland population-based case-control study recruited 224 Barrett's oesophagus patients, 227 oesophageal adenocarcinoma patients and 260 controls. All participants underwent a structured interview with information obtained about potential lifestyle and environmental risk factors.
  
  
  RESULTS
  Gastro-oesophageal reflux was associated with Barrett's [OR 12.0 (95% CI 7.64-18.7)] and oesophageal adenocarcinoma [OR 3.48 (95% CI 2.25-5.41)]. Oesophageal adenocarcinoma patients were more likely than controls to be ex- or current smokers [OR 1.72 (95% CI 1.06-2.81) and OR 4.84 (95% CI 2.72-8.61) respectively] and to have a high body mass index [OR 2.69 (95% CI 1.62-4.46)]. No significant associations were observed between these risk factors and Barrett's oesophagus. Fruit but not vegetables were negatively associated with oesophageal adenocarcinoma [OR 0.50 (95% CI 0.30-0.86)].
  
  
  CONCLUSIONS
  A high body mass index, a diet low in fruit and cigarette smoking may be involved in the progression from Barrett's oesophagus to oesophageal adenocarcinoma.
authors.affiliation: Centre for Clinical and Population Sciences, Queen's University, Mulhouse Building, Grosvenor Road, Belfast, BT12 6BJ, Northern Ireland. l.anderson@qub.ac.uk
authors.forename: Lesley A
authors.initials: LA
authors.lastname: Anderson
authors.forename: R G Peter
authors.initials: RG
authors.lastname: Watson
authors.forename: Seamus J
authors.initials: SJ
authors.lastname: Murphy
authors.forename: Brian T
authors.initials: BT
authors.lastname: Johnston
authors.forename: Harry
authors.initials: H
authors.lastname: Comber
authors.forename: Jim
authors.initials: J
authors.lastname: Mc Guigan
authors.forename: John V
authors.initials: JV
authors.lastname: Reynolds
authors.forename: Liam J
authors.initials: LJ
authors.lastname: Murray
mesh_terms: D000230:Adenocarcinoma / Q000453:epidemiology*; D000368:Aged; D001471:Barrett Esophagus / Q000453:epidemiology*; D015992:Body Mass Index; D016022:Case-Control Studies; D004032:Diet; D018450:Disease Progression; D004938:Esophageal Neoplasms / Q000453:epidemiology*; D005260:Female; D005638:Fruit; D005764:Gastroesophageal Reflux / Q000150:complications / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009660:Northern Ireland; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects