title: Diagnostic value of multidetector-row CT angiography in the evaluation of thrombosis of the cerebral venous sinuses.
abstract: OBJECTIVE
  The diagnosis of cerebral venous and sinus thrombosis (CVST) as a rare but important cause of stroke is challenging. We aimed to investigate the diagnostic value of multidetector-row CT angiography (MDCTA) as a fast and cost-effective imaging tool in diagnosing CVST.
  
  
  METHODS
  Nineteen patients who presented with clinical symptoms of a possible CVST were included. All patients had received both MDCTA and MR imaging with venous MR-angiography. Three blinded readers were asked to identify the cerebral sinuses and veins in MDCTA and to evaluate the presence of CVST in MDCTA. Consensus reading with interpretation of the MR imaging served to establish the definite diagnosis.
  
  
  RESULTS
  The consensus reading revealed CVST in 10 of the 19 patients. With MDCTA, the venous sinuses could be identified in 99.2% and the cerebral veins in 87.6% of cases. The sensitivity and specificity of MDCTA for the diagnosis of CVST were 100%.
  
  
  CONCLUSIONS
  Our study demonstrates that MDCTA provides excellent sensitivity and specificity for the diagnosis of CVST. Further studies are needed to evaluate the diagnostic potential of MDCTA in specific subsets of the general entity of CVST such as cortical venous thrombosis, thrombosis of the cavernous sinus, and thrombosis of the internal cerebral veins.
authors.affiliation: Department of Neuroradiology, University Hospital Munich, Grosshadern, Munich, Germany. linn@nrad.de
authors.forename: J
authors.initials: J
authors.lastname: Linn
authors.forename: B
authors.initials: B
authors.lastname: Ertl-Wagner
authors.forename: K C
authors.initials: KC
authors.lastname: Seelos
authors.forename: M
authors.initials: M
authors.lastname: Strupp
authors.forename: M
authors.initials: M
authors.lastname: Reiser
authors.forename: H
authors.initials: H
authors.lastname: Brückmann
authors.forename: R
authors.initials: R
authors.lastname: Brüning
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002533:Cerebral Angiography / Q000191:economics / Q000379:methods*; D003362:Cost-Benefit Analysis; D003392:Cranial Sinuses / Q000000981:diagnostic imaging*; D016208:Databases, Factual; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010690:Phlebography / Q000379:methods*; D012680:Sensitivity and Specificity; D012851:Sinus Thrombosis, Intracranial / Q000000981:diagnostic imaging*; D014057:Tomography, X-Ray Computed / Q000191:economics / Q000379:methods*