[The effect of caffeine and sodium fluoride on fluoride concentration in serum and its content in teeth and bones of rats].
OBJECTIVE
The aim of this work was to determine the effect of sodium fluoride at a dose of 4.9 mg/kg b.w./24 h and caffeine at a dose of 3 mg/kg b.w./24 h on the concentration of fluoride in serum and its content in teeth and bones of rats.


METHODS
The study was done in 18 male Sprague-Dawley rats.


CONCLUSIONS
A negative effect of caffeine administered concurrently with sodium fluoride on teeth and bones of rats was demonstrated as reflected by a tendency to increased content of fluoride in bones and decreased content in teeth.
Grucka-Mamczar
Ewa
E
Zakład Biochemii Ogólnej, Katedra Biochemii Slqskiej Akademii Medycznej w Katowicach ul. Jordana 19, 41-808 Zabrze.
Chlubek
Dariusz
D
Birkner
Ewa
E
Zalejska-Fiolka
Jolanta
J
Błaszczyk
Iwona
I
Kasperczyk
Sławomir
S
Stawiarska-Pieta
Barbara
B
D000818:Animals; D001842:Bone and Bones / Q000737:chemistry* / Q000187:drug effects; D002110:Caffeine / Q000008:administration & dosage / Q000633:toxicity*; D004347:Drug Interactions; D005457:Fluoridation / Q000009:adverse effects; D005459:Fluorides / Q000032:analysis* / Q000097:blood; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D044967:Serum / Q000737:chemistry / Q000187:drug effects; D012969:Sodium Fluoride / Q000008:administration & dosage / Q000633:toxicity*; D014070:Tooth / Q000737:chemistry* / Q000187:drug effects
D002110:Caffeine; D012969:Sodium Fluoride; D005459:Fluorides