ICAM-1 expressed on hepatic stellate cells plays an important role in immune regulation.
The authors have demonstrated a strong T-cell inhibitory activity of hepatic stellate cells (HSC), which may participate in the establishment of hepatic tolerance. The underlying mechanism is not completely understood. This study showed that intercellular adhesion molecule 1 (ICAM-1) was constitutively expressed on HSC, and up-regulated upon activation. ICAM-1 knockout mice was used to analyze the role of ICAM-1 expressed on HSC, and showed that deficiency in ICAM-1 expression partially reverses HSC immune inhibitory activity both in vitro and in vivo, but did not significantly affect their capacity to induce T-cell apoptosis.
Yin
Zhenyu
Z
Department of Immunology, Cleveland Clinic, Cleveland, OH 44195, USA.
Jiang
Guoping
G
Fung
John J
JJ
Lu
Lina
L
Qian
Shiguang
S
D000818:Animals; D017304:Annexin A5 / Q000378:metabolism; D017209:Apoptosis; D018929:Cell Culture Techniques; D003921:Diabetes Mellitus, Experimental / Q000276:immunology; D005434:Flow Cytometry / Q000379:methods; D006085:Graft Survival; D022781:Hepatocytes / Q000276:immunology / Q000637:transplantation*; D018799:Intercellular Adhesion Molecule-1 / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D016381:Islets of Langerhans Transplantation / Q000276:immunology* / Q000379:methods / Q000473:pathology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D013601:T-Lymphocytes / Q000276:immunology*; D013997:Time Factors; D014184:Transplantation, Homologous
D017304:Annexin A5; D018799:Intercellular Adhesion Molecule-1