title: Isoprenylated flavonoids from the stem bark of Erythrina abyssinica.
abstract: Three new prenylated flavanones, abyssinoflavanones V, VI, and VII (1-3), together with eight known flavanones (4-11) and two chalcones (12-13), were isolated from the stem bark of Erythrina abyssinica. Their structures were elucidated on the basis of spectroscopic and physicochemical analyses. All the isolates, with the exception of 1 and 8, strongly inhibited PTP1B activity in an in vitro assay with IC50 values ranging from 14.2 +/- 1.7 to 26.7 +/- 1.2 microM.
authors.affiliation: Korea Research Institute of Bioscience and Biotechnology, 52 Eoun-dong, Yuseong-gu, Daejeon 305-806, Korea.
authors.forename: Long
authors.initials: L
authors.lastname: Cui
authors.forename: Derek Tantoh
authors.initials: DT
authors.lastname: Ndinteh
authors.forename: MinKyun
authors.initials: M
authors.lastname: Na
authors.forename: Phuong Thien
authors.initials: PT
authors.lastname: Thuong
authors.forename: John
authors.initials: J
authors.lastname: Silike-Muruumu
authors.forename: Dieudonné
authors.initials: D
authors.lastname: Njamen
authors.forename: Joseph Tanyi
authors.initials: JT
authors.lastname: Mbafor
authors.forename: Zacharias Tanee
authors.initials: ZT
authors.lastname: Fomum
authors.forename: Jong Seog
authors.initials: JS
authors.lastname: Ahn
authors.forename: Won Keun
authors.initials: WK
authors.lastname: Oh
mesh_terms: D004895:Erythrina / Q000737:chemistry*; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1; D017027:Protein Tyrosine Phosphatases / Q000037:antagonists & inhibitors* / Q000235:genetics; D014454:Uganda
chemical_list: D005419:Flavonoids; C516607:PTPN1 protein, human; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1; D017027:Protein Tyrosine Phosphatases