title: Minocycline-induced acute eosinophilic pneumonia: controversial results of lymphocyte stimulation test and re-challenge test.
abstract: We report an instructive case of minocycline-induced eosinophilic pneumonia confirmed by re-challenge test, in which a preceding lymphocyte-stimulation test indicated acetaminophen as the etiologic agent. A 55-year-old woman developed high fever and lung infiltrates with pulmonary eosinophilia after exposure to minocycline, acetaminophen, theophylline and procaterol. All of the medicines were discontinued, resulting in prompt improvement. The lymphocyte stimulation tests provided a positive result for acetaminophen, but not for the other medicines; however, a negative result was given by a re-challenge test with acetaminophen. In contrast, symptoms and hypoxemia reappeared when minocycline was re-administered. We would like to emphasize that lymphocyte stimulation test results need to be carefully interpreted for individual drugs.
authors.affiliation: Division of Pulmonary Disease, Oita University Faculty of Medicine, Oita, Japan.
authors.forename: Emiko
authors.initials: E
authors.lastname: Ono
authors.forename: Eishi
authors.initials: E
authors.lastname: Miyazaki
authors.forename: Osamu
authors.initials: O
authors.lastname: Matsuno
authors.forename: Shin-ichi
authors.initials: S
authors.lastname: Nureki
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Okubo
authors.forename: Masaru
authors.initials: M
authors.lastname: Ando
authors.forename: Toshihide
authors.initials: T
authors.lastname: Kumamoto
mesh_terms: D000082:Acetaminophen / Q000009:adverse effects; D000208:Acute Disease; D018712:Analgesics, Non-Narcotic / Q000009:adverse effects; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D005188:False Negative Reactions; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D000860:Hypoxia / Q000139:chemically induced; D007158:Immunologic Techniques / Q000592:standards*; D008213:Lymphocyte Activation; D008875:Middle Aged; D008911:Minocycline / Q000009:adverse effects*; D011657:Pulmonary Eosinophilia / Q000139:chemically induced* / Q000000981:diagnostic imaging; D013902:Radiography, Thoracic; D014057:Tomography, X-Ray Computed
chemical_list: D018712:Analgesics, Non-Narcotic; D000900:Anti-Bacterial Agents; D000082:Acetaminophen; D008911:Minocycline