The solution conformation of C-glycosyl analogues of the sialyl-Tn antigen.
The conformational behavior of two C-glycosyl analogues of the sialyl-Tn antigen has been determined by a combination of NMR methods and molecular mechanics calculations. Both compounds show a major solution conformation that is drastically different from the major one of the natural compound.
García-Aparicio
Víctor
V
Centro de Investigaciones Biológicas, CSIC, Ramiro de Maeztu 9, 28040 Madrid, Spain.
Malapelle
Adeline
A
Abdallah
Zouleika
Z
Doisneau
Gilles
G
Santos
José Ignacio
JI
Asensio
Juan Luis
JL
Cañada
Francisco Javier
FJ
Beau
Jean Marie
JM
Jiménez-Barbero
Jesús
J
D015295:Antigens, Tumor-Associated, Carbohydrate / Q000737:chemistry*; D002236:Carbohydrate Conformation; D004187:Disaccharides / Q000737:chemistry; D006031:Glycosylation; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation; D019158:N-Acetylneuraminic Acid / Q000737:chemistry*; D012996:Solutions
D015295:Antigens, Tumor-Associated, Carbohydrate; D004187:Disaccharides; D012996:Solutions; C040286:Tn antigen; D019158:N-Acetylneuraminic Acid