title: The long-term effect of AHSCT on MRI measures of MS evolution: a five-year follow-up study.
abstract: Using MRI, we measured disease activity and brain atrophy in nine multiple sclerosis patients treated with autologous hematopoietic stem cell transplantation (AHSCT) for a mean follow up of 63 months. We show that AHSCT is associated to a longlasting suppression of inflammation and to a marked decrease of the rate of brain atrophy after the second year following treatment.
authors.affiliation: Department of Neuroscience, Ophtalmology and Genetics, University of Genoa, Genoa.
authors.forename: L
authors.initials: L
authors.lastname: Roccatagliata
authors.forename: Ma
authors.initials: M
authors.lastname: Rocca
authors.forename: P
authors.initials: P
authors.lastname: Valsasina
authors.forename: L
authors.initials: L
authors.lastname: Bonzano
authors.forename: Mp
authors.initials: M
authors.lastname: Sormani
authors.forename: R
authors.initials: R
authors.lastname: Saccardi
authors.forename: Gl
authors.initials: G
authors.lastname: Mancardi
authors.forename: M
authors.initials: M
authors.lastname: Filippi
mesh_terms: D000328:Adult; D017668:Age of Onset; D001284:Atrophy; D001921:Brain / Q000473:pathology; D003520:Cyclophosphamide / Q000627:therapeutic use; D005500:Follow-Up Studies; D019650:Hematopoietic Stem Cell Mobilization / Q000379:methods; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007249:Inflammation / Q000517:prevention & control; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000473:pathology* / Q000628:therapy*; D014182:Transplantation, Autologous
chemical_list: D003520:Cyclophosphamide