title: Studies on preparation and absolute bioavailability of a self-emulsifying system containing puerarin.
abstract: The purpose of the study was to develop an optimum formulation of self-emulsifying drug delivery systems (SEDDS) containing puerarin and to evaluate its absolute bioavailability. Using oleic acid as oil, Tween-80 as surfactant and propylene glycol as cosurfactant, a series of mixtures comprising oleic acid, propylene glycol and Tween 80 were prepared and their self-emulsifying properties were studied. Pseudo-ternary phase diagrams were constructed to identify the efficient self-emulsification region and particle sizes of the resultant emulsions were determined using a laser diffraction sizer. From these studies, an optimized formulation consisting of oil (17.5%), Tween-80 (34.5%) and cosurfactant (34.5%) was selected and its absolute bioavailability in beagle dogs after oral administration was about 24.8%. The data suggest the use of SEDDS to provide a potential way of puerarin administered orally.
authors.affiliation: Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, China. wzbqdq@sohu.com
authors.forename: Dong-qin
authors.initials: DQ
authors.lastname: Quan
authors.forename: Gui-xia
authors.initials: GX
authors.lastname: Xu
authors.forename: Xiang-gen
authors.initials: XG
authors.lastname: Wu
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics*; D000818:Animals; D001682:Biological Availability; D002626:Chemistry, Pharmaceutical; D004285:Dogs; D016503:Drug Delivery Systems; D004655:Emulsions; D007529:Isoflavones / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics*; D009821:Oils; D012995:Solubility; D013501:Surface-Active Agents
chemical_list: D000319:Adrenergic beta-Antagonists; D004655:Emulsions; D007529:Isoflavones; D009821:Oils; D013501:Surface-Active Agents; C033607:puerarin