Cells, cells, and more cells.
A 64-year-old woman presented with bilateral optic nerve swelling, vitreous cells, and cerebrospinal fluid monocytic pleocytosis. A chest radiograph and computed tomography demonstrated a lesion in the left lung, which histologically was confirmed to be a small-cell lung carcinoma. The serum was positive for the anti-CV2 (anti-CRMP-5) antibody. Following treatment with chemoradiation the optic nerve swelling and vitritis resolved. The differential diagnosis of uveal-meningeal diseases is discussed and the pathophysiology and clinical manifestations of paraneoplastic syndromes reviewed.
Bhatti
M Tariq
MT
Department of Ophthalmology, Duke University Eye Center and Duke University Medical Center, Durham, North Carolina 27710, USA.
Gres
Katherine E
KE
Petitto
Virginia B
VB
Cross
Shelley Ann
SA
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D018288:Carcinoma, Small Cell / Q000000981:diagnostic imaging / Q000473:pathology* / Q000628:therapy; D003131:Combined Modality Therapy; D005128:Eye Diseases / Q000000981:diagnostic imaging / Q000473:pathology* / Q000628:therapy; D005260:Female; D006801:Humans; D006867:Hydrolases; D008175:Lung Neoplasms; D008279:Magnetic Resonance Imaging; D008869:Microtubule-Associated Proteins; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000097:blood; D010211:Papilledema / Q000000981:diagnostic imaging / Q000473:pathology* / Q000628:therapy; D010257:Paraneoplastic Syndromes / Q000000981:diagnostic imaging / Q000473:pathology* / Q000628:therapy; D013902:Radiography, Thoracic; D020266:Radiotherapy, Conformal; D014057:Tomography, X-Ray Computed; D014822:Vitreous Body / Q000473:pathology*
D008869:Microtubule-Associated Proteins; D009419:Nerve Tissue Proteins; C415087:DPYSL5 protein, human; D006867:Hydrolases