Anti-babesial compounds from Curcuma xanthorrhiza.
Anti-babesial ingredients, (12R)- and (12S)-12,13-dihydro-12,13-dihydroxyxanthorrhizols, were isolated from Curcuma xanthorrhiza. The structures were established by the extensive NMR techniques. The assignments of (1)H NMR data of (12R)-12,13-dihydro-12,13-dihydroxyxanthorrhizol was revised, and (12S)-12,13-dihydro-12,13-dihydroxyxanthorrhizol was isolated as a pure form for the first time. The IC(50) of the active compounds were compared with that of commercial drug, diminazene aceturate (Ganaseg). IC(50) values of Ganaseg, (12R)-, and (12S)-12,13-dihydro-12,13-dihydroxyxanthorrhizols were 0.6 microg mL(-1), 8.3 microg mL(-1) and 11.6 microg mL(-1), respectively.
Matsuura
Hideyuki
H
Laboratory of Bioorganic Chemistry, Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo 060-8589, Japan. matsuura@chem.agr.hokudai.ac.jp
Nomura
Shinkichi
S
Subeki
Yamada
Kazuaki
K
Yamasaki
Masahiro
M
Yamato
Osamu
O
Maede
Yoshimitsu
Y
Katakura
Ken
K
Trimurningsih
Chairul
Yoshihara
Teruhiko
T
Nabeta
Kensuke
K
D000818:Animals; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001403:Babesia / Q000187:drug effects* / Q000254:growth & development; D030024:Curcuma / Q000737:chemistry*; D007214:Indonesia; D020128:Inhibitory Concentration 50; D013058:Mass Spectrometry; D019906:Nuclear Magnetic Resonance, Biomolecular; D009904:Optical Rotation; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
D000981:Antiprotozoal Agents; D010636:Phenols