title: Changing patterns of thyroid carcinoma.
abstract: BACKGROUND
  To assess changing trends in histological types of thyroid cancer in an Irish hospital over the past 30 years.
  
  
  METHODS
  Biographical data, tumour characteristics, treatment and outcome from 190 patients with thyroid carcinoma from 1970 to 2000 were reviewed retrospectively.
  
  
  RESULTS
  Detailed records of 190 patients with thyroid cancer were identified with a mean age at presentation of 50 years. From 1970 to 1979 the distribution of histological types was: papillary carcinoma; 9 patients (4.7%), follicular; 17 patients (8.9%), anaplastic; 9 patients (4.7%), medullary; 1 patient (0.5%) and lymphoma; 1 patient (0.5%). From 1980 to 1989 papillary carcinoma accounted for 32 patients (16.8%), follicular; 14 patients (7.3%), anaplastic; 13 patients (6.8%), medullary; 7 patients (3.7%) and lymphoma; 5 patients (2.6%). From 1990 to 1999 papillary cancer accounted for 48 patients (25.2%), follicular; 14 patients (7.3%), anaplastic; 8 patients (4.2%), medullary; 7 patients (3.7%) and lymphoma; 5 patients (2.6%). Survival rates were significantly better for those aged less than 45 years (P < 0.0001), female sex (P < 0.01) and those with papillary carcinoma (P < 0.01).
  
  
  CONCLUSIONS
  This study demonstrated a significant increase in the incidence of papillary carcinoma. This may be related to increasing dietary iodine intake and may be significant as papillary carcinoma is associated with a more favourable prognosis.
authors.affiliation: Department of Surgery, St Vincent's University Hospital, Elm Park, Dublin 4, Ireland.
authors.forename: B
authors.initials: B
authors.lastname: Dijkstra
authors.forename: R S
authors.initials: RS
authors.lastname: Prichard
authors.forename: A
authors.initials: A
authors.lastname: Lee
authors.forename: L M
authors.initials: LM
authors.lastname: Kelly
authors.forename: P P A
authors.initials: PP
authors.lastname: Smyth
authors.forename: T
authors.initials: T
authors.lastname: Crotty
authors.forename: E W
authors.initials: EW
authors.lastname: McDermott
authors.forename: A D K
authors.initials: AD
authors.lastname: Hill
authors.forename: N
authors.initials: N
authors.lastname: O'Higgins
mesh_terms: D000367:Age Factors; D002291:Carcinoma, Papillary / Q000453:epidemiology; D004032:Diet; D005260:Female; D006801:Humans; D015994:Incidence; D007455:Iodine / Q000008:administration & dosage; D007494:Ireland / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D013964:Thyroid Neoplasms / Q000453:epidemiology* / Q000401:mortality / Q000473:pathology*
chemical_list: D007455:Iodine