Memories are made of this: synergy of T cell receptor and cytokine signals in CD4(+) central memory cell survival.
The ability of the immune system to 'remember' a previous encounter with antigen is the hallmark of the adaptive immune response. The signals required for CD4(+) memory T cell survival are not well understood, and a recent paper lends new biochemical insights into how memory T cells might optimally be preserved through the convergence of signals from the engagement of cytokine and antigen-specific T cell receptors.
Caserta
Stefano
S
MRC National Institute for Medical Research, London, UK, NW7 1AA.
Zamoyska
Rose
R
D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D002470:Cell Survival; D016207:Cytokines / Q000502:physiology*; D000071316:Forkhead Box Protein O3; D051858:Forkhead Transcription Factors / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D007156:Immunologic Memory; D010766:Phosphorylation; D011948:Receptors, Antigen, T-Cell / Q000502:physiology*; D015398:Signal Transduction
D016207:Cytokines; C499517:FOXO3 protein, human; D000071316:Forkhead Box Protein O3; D051858:Forkhead Transcription Factors; D011948:Receptors, Antigen, T-Cell