Aberrant expression of keratinocyte growth factor receptor in ovarian surface epithelial cells of endometrioma.
Ovarian surface epithelial cells (OSEs) are considered to be the common source of endometrioma and epithelial ovarian cancer. The present study reveals that keratinocyte growth factor receptor (KGFR) messenger RNA was expressed in OSEs of endometriomas but not in those of normal ovaries, suggesting that autocrine KGF/KGFR and paracrine fibroblast growth factor 10/KGFR signaling loops may be involved with the proliferation in OSEs of endometrioma.
Taniguchi
Fuminori
F
Department of Obstetrics and Gynecology, Tottori University School of Medicine, Yonago, Japan. tani4327@grape.med.tottori-u.ac.jp
Harada
Tasuku
T
Iwabe
Tomio
T
Ohama
Yoko
Y
Takenaka
Yasuko
Y
Terakawa
Naoki
N
D002478:Cells, Cultured; D004715:Endometriosis / Q000235:genetics* / Q000378:metabolism; D004847:Epithelial Cells / Q000378:metabolism*; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D010049:Ovarian Diseases / Q000235:genetics* / Q000378:metabolism; D010053:Ovary / Q000378:metabolism*; D051497:Receptor, Fibroblast Growth Factor, Type 2 / Q000235:genetics* / Q000378:metabolism
D051497:Receptor, Fibroblast Growth Factor, Type 2; C065104:keratinocyte growth factor receptor