title: HPV-related vulvar intraepithelial neoplasia: outcome of different management modalities.
abstract: OBJECTIVE
  To evaluate the outcome of various management schemes for HPV-related vulvar intraepithelial neoplasia (VIN, usual type).
  
  
  METHODS
  Retrospective chart review of patients with histologically diagnosed grade 2/3-VIN who had at least one year of follow-up. The variables that were collected included patient characteristics, management modalities, and clinical outcome.
  
  
  RESULTS
  Fifty patients with a median age of 45 years old were evaluated. The median duration of follow-up was 43.5 months (12-186). Complete response (CR) and partial response occurred in 28 (56%) and 4 (8%), respectively. Nineteen of 28 patients with CR recurred with VIN. Surgical excision yielded higher CR (77%) than did either ablational techniques (21-33%) or topical immunotherapy (33%).
  
  
  CONCLUSIONS
  In this experience, surgical excision for VIN, usual type, resulted in better therapeutic success rates than other treatment modalities. Management schemes should be individualized based on extent of disease and patient compliance.
authors.affiliation: Division of Gynecologic Oncology, Sir Mortimer B. Davis-Jewish General Hospital, Montreal, Quebec, Canada.
authors.forename: I
authors.initials: I
authors.lastname: Bruchim
authors.forename: W H
authors.initials: WH
authors.lastname: Gotlieb
authors.forename: S
authors.initials: S
authors.lastname: Mahmud
authors.forename: E
authors.initials: E
authors.lastname: Tunitsky
authors.forename: K
authors.initials: K
authors.lastname: Grzywacz
authors.forename: A
authors.initials: A
authors.lastname: Ferenczy
mesh_terms: D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D000634:Aminoquinolines / Q000627:therapeutic use; D002278:Carcinoma in Situ / Q000628:therapy* / Q000821:virology; D017115:Catheter Ablation / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D000077271:Imiquimod; D053685:Laser Therapy / Q000379:methods; D008875:Middle Aged; D030361:Papillomavirus Infections / Q000150:complications*; D011230:Precancerous Conditions / Q000628:therapy* / Q000821:virology; D012189:Retrospective Studies; D016896:Treatment Outcome; D014846:Vulvar Neoplasms / Q000628:therapy* / Q000821:virology
chemical_list: D000276:Adjuvants, Immunologic; D000634:Aminoquinolines; D000077271:Imiquimod