Increased expression of platelet-derived growth factor C messenger ribonucleic acid in uterine leiomyomata.
This study was intended to investigate the possible roles of the platelet-derived growth factor (PDGF) gene family's involvement in the pathogenesis of uterine leiomyomata. We examined the differential gene expressions of PDGF-A, -B, -C, -D, PDGF receptor alpha (PDGFR-alpha), and receptor beta (PDGFR-beta) between uterine leiomyomata and the adjacent normal myometrium. Expression of PDGF-C in leiomyomata was significantly higher (approximately 2.4-fold) than in the adjacent normal myometrium, whereas there were no significant differences in the expressions of PDGF-A, -B, -D, PDGFR-alpha, or PDGFR-beta between leiomyomata and the adjacent myometrial tissues.
Hwu
Yuh-Ming
YM
Department of Obstetrics and Gynecology, Mackay Memorial Hospital, Taipei, Taiwan.
Li
Sheng-Hsiang
SH
Lee
Robert Kuo-kuang
RK
Tsai
Yu-Hui
YH
Yeh
Tien-Shun
TS
Lin
Shyr-Yeu
SY
D000328:Adult; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D018231:Leiomyomatosis / Q000235:genetics* / Q000378:metabolism; D008222:Lymphokines / Q000235:genetics*; D016555:Matched-Pair Analysis; D008875:Middle Aged; D005810:Multigene Family; D009215:Myometrium / Q000378:metabolism; D010982:Platelet-Derived Growth Factor / Q000235:genetics*; D012333:RNA, Messenger / Q000378:metabolism; D017479:Receptors, Platelet-Derived Growth Factor / Q000235:genetics / Q000378:metabolism; D015854:Up-Regulation; D014594:Uterine Neoplasms / Q000235:genetics* / Q000378:metabolism
D008222:Lymphokines; D010982:Platelet-Derived Growth Factor; D012333:RNA, Messenger; C411423:platelet-derived growth factor C; D017479:Receptors, Platelet-Derived Growth Factor