[A prospective study on the prevalence of metabolic syndrome among healthy French families: the importance of plasma concentration of TNF-alpha in addition to its genetic polymorphism].
Metabolic syndrome (MS) is a cluster of synergistically interacting cardiovascular risk factors which may have serious consequences for the development of cardiovascular disease and diabetes. In this study, we aimed to estimate the prevalence of MS within presumably healthy French families of the STANISLAS cohort, and to observe biological parameters involved in cardiovascular diseases among the offspring of MS subjects. 371 apparently healthy families (1366 individuals) were examined at two visits with a five-year interval (t0 and t+5). MS prevalence was assessed among parents following the ATP-III definition. Our results show that MS is present in presumably healthy adults of the STANISLAS cohort and increases with age. Moreover, low HDL-C and TNF-alpha may play an important role in the development of MS in childhood, at least in our population. Therefore, a systematic tracking of MS appears to be all the more important as it will permit early management of MS in parents and the installation of efficient preventive measures in children including specific advice for diet and physical activity.
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Inserm U525, Faculté de pharmacie, UHP Nancy 1, 30, rue Lionnois, F 54000 Nancy.
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Visvikis-Siest
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D005602:France / Q000453:epidemiology; D006801:Humans; D024821:Metabolic Syndrome / Q000453:epidemiology / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics; D011446:Prospective Studies; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics* / Q000502:physiology*
D014409:Tumor Necrosis Factor-alpha