Molecular reaction mechanisms of combination treatments of low-dose cisplatin with radiotherapy and photodynamic therapy.
Combination of low-dose cisplatin with radiotherapy or photodynamic therapy (PDT) is a novel cancer treatment. Using time-resolved femtosecond laser spectroscopy, we reveal the molecular mechanisms of the combinations of cisplatin with radiotherapy and PDT using indocyanine green (ICG) excited at 800 nm. DNA damage measurements confirm that electron-transfer reactions of cisplatin with electrons generated in ionizing radiation and with the ICG singlet excited state in PDT are responsible for the cytotoxic enhancements.
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Departments of Physics and Chemistry, University of Waterloo, 200 University Avenue West, Waterloo, Ontario N2L 3G1, Canada. qblu@uwaterloo.ca
D000970:Antineoplastic Agents / Q000737:chemistry*; D002945:Cisplatin / Q000737:chemistry*; D003131:Combined Modality Therapy; D004249:DNA Damage; D004579:Electron Transport; D007834:Lasers; D009930:Organic Chemicals / Q000737:chemistry*; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000737:chemistry*; D011878:Radiotherapy; D013057:Spectrum Analysis / Q000379:methods; D014466:Ultraviolet Rays
D000970:Antineoplastic Agents; D009930:Organic Chemicals; D017319:Photosensitizing Agents; C035709:iodocyanine green; D002945:Cisplatin