Aqueous humor and serum concentration of hydroxyproline in pseudoexfoliation syndrome.
OBJECTIVE
To determine the concentration of hydroxyproline (Hyp) in aqueous humor and serum samples of patients with and without pseudoexfoliation (PEX).


METHODS
Aqueous humor and serum Hyp levels were measured in cataract patients. Patients were divided into PEX and control groups. Samples were obtained from 27 cataract patients with PEX and 25 cataract patients without PEX. Patients had no elevated intraocular pressure or glaucoma. Hyp concentration was determined spectrophotometrically.


RESULTS
Mean Hyp concentration in the PEX aqueous (0.86+/-0.27 mg/L) and serum (40.8+/-6.14 mg/L) samples was significantly higher than that measured in the control aqueous (0.56+/-0.2 mg/L) and serum (34.51+/-6.82 mg/L) samples, respectively (P<0.001, P=0.001). No significant correlation could be found between aqueous humor and serum Hyp concentrations.


CONCLUSIONS
The higher levels of Hyp could be a sign of increased collagen turnover in PEX syndrome.
Yagci
Ramazan
R
Department of Ophthalmology, Medical School, Fatih University, Ankara, Turkey. ramazanyagci@yahoo.com
Ersöz
Ibrahim
I
Aydin
Bahri
B
Beyaz
Elif
E
Gürel
Ahmet
A
Durmuş
Mustafa
M
Duman
Sunay
S
D000368:Aged; D001082:Aqueous Humor / Q000378:metabolism*; D002386:Cataract / Q000150:complications; D003094:Collagen / Q000378:metabolism; D017889:Exfoliation Syndrome / Q000097:blood* / Q000150:complications; D005260:Female; D006801:Humans; D006909:Hydroxyproline / Q000097:blood*; D008297:Male; D008875:Middle Aged; D018918:Phacoemulsification
D003094:Collagen; D006909:Hydroxyproline