title: From broken to old: DNA damage, IGF1 endocrine suppression and aging.
abstract: Two recent reports provide new information on how DNA damage may generate progeroid changes at the cell and organismal level by suppressing growth hormone (GH)/insulin-like growth factor 1 (IGF1) endocrine signaling. This endocrine signaling pathway is of particular interest as it is a key regulator of metabolism and longevity in many organisms.
authors.affiliation: Department of Pathology, University of Washington, Box 357705 Seattle, WA 98195-7705, United States. monnat@u.washington.edu
authors.forename: Raymond J
authors.initials: RJ
authors.lastname: Monnat
mesh_terms: D000375:Aging; D000818:Animals; D004249:DNA Damage; D004702:Endocrine Glands / Q000378:metabolism*; D013006:Growth Hormone / Q000378:metabolism*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D008136:Longevity; D011371:Progeria; D015398:Signal Transduction
chemical_list: D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone