title: Lack of CXCR3 delays the development of hepatic inflammation but does not impair resistance to Leishmania donovani.
abstract: CXC chemokine receptor 3 (CXCR3) ligands CXCL9 and CXCL10 are produced at high levels in mice and humans infected with Leishmania donovani, but their contribution to host resistance against L. donovani is not clear. Here, using CXCR3(-/-) mice, we demonstrate that, although CXCR3 regulates early immune cell trafficking and hepatic inflammation during L. donovani infection, it is not essential for immunity against L. donovani, unlike L. major. CXCR3(-/-) C57BL/6 mice show a delayed onset of hepatic inflammation and granuloma formation after L. donovani infection. However, they mount an efficient T helper cell type 1 response, recruit T cells to the liver, and control parasite growth as efficiently as do CXCR3(+/+) C57BL/6 mice.
authors.affiliation: Department of Microbiology, The Ohio State University, Columbus, OH 43221, USA.
authors.forename: Joseph
authors.initials: J
authors.lastname: Barbi
authors.forename: Steve
authors.initials: S
authors.lastname: Oghumu
authors.forename: Lucia E
authors.initials: LE
authors.lastname: Rosas
authors.forename: Tracy
authors.initials: T
authors.lastname: Carlson
authors.forename: Bao
authors.initials: B
authors.lastname: Lu
authors.forename: Craig
authors.initials: C
authors.lastname: Gerard
authors.forename: Claudio M
authors.initials: CM
authors.lastname: Lezama-Davila
authors.forename: Abhay R
authors.initials: AR
authors.lastname: Satoskar
mesh_terms: D000818:Animals; D006224:Cricetinae; D016207:Cytokines / Q000378:metabolism; D005260:Female; D006099:Granuloma / Q000276:immunology / Q000469:parasitology; D006801:Humans; D007249:Inflammation / Q000276:immunology* / Q000469:parasitology; D007893:Leishmania donovani / Q000472:pathogenicity*; D007898:Leishmaniasis, Visceral / Q000276:immunology* / Q000469:parasitology / Q000473:pathology; D008099:Liver / Q000276:immunology / Q000469:parasitology / Q000473:pathology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D054367:Receptors, CXCR3; D019707:Receptors, Chemokine / Q000378:metabolism*; D013154:Spleen / Q000276:immunology / Q000469:parasitology
chemical_list: C515187:CXCR3 protein, human; C515188:Cxcr3 protein, mouse; D016207:Cytokines; D054367:Receptors, CXCR3; D019707:Receptors, Chemokine