Comprehensive overview of the mechanisms involved in the development of tumour - related anaemias.
The aim of this survey was to give a brief account of the pathological mechanisms underlying the development of anaemias in patients with oncological diseases. These anaemias develop secondarily, as a spin-off of the main disease. There exist a great variety of complex pathological mechanisms that interweave with one another. Oncological diseases are characterized by impairment in erythropoiesis, reduced periods of erythrocytes' survival and loss of blood, which appear to be the main pathological factors for the development of anaemia. Different forms of anaemias in cancer patients have been described in the medical literature, such as iron-deficiency anaemias, megaloblastic anaemias, hemolytic anaemias, myelogenic anaemias, sideroblastic anaemias, as well as anaemias caused by antitumor therapy.
Ivanov
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Department of Chemistry and Biochemistry, Thracian University, Faculty of Medicine, Stara Zagora, Bulgaria.