Intrapulmonary solitary fibrous tumor diagnosed by immunohistochemical and genetic approaches: report of a case.
Although solitary fibrous tumors (SFTs) of the pleura are not uncommon, intrapulmonary SFTs are extremely rare. A 72-year-old woman was admitted to our hospital for an investigation of an enlarging intrapulmonary tumor. Because a definitive diagnosis could not be readily established, a pulmonary wedge resection under video-assisted thoracic surgery was performed. Grossly, the tumor was white, well circumscribed, and separate from the pleural surface. Histologically, it consisted of spindle cells proliferating in a vague fascicular pattern, with many dilated capillaries, and intermingled glandular components. These findings suggested a differential diagnosis that included SFT and nonchondromatous pulmonary hamartoma. On immunohistochemical analysis, the spindle cells showed a strong positive reaction to the CD34 antigen. Interphase fluorescent in situ hybridization revealed an absence of HMGA-1 and -2 translocations. These results supported a diagnosis of SFT. A genetic approach may therefore be useful in the differentiation of SFT from nonchondromatous hamartoma.
Sagawa
Motoyasu
M
Department of Thoracic Surgery, Kanazawa Medical University, 1-1 Daigaku, Uchinada, Ishikawa 920-0293, Japan.
Ueda
Yoshimichi
Y
Matsubara
Fujitsugu
F
Sakuma
Hiroshi
H
Yoshimitsu
Yutaka
Y
Aikawa
Hirokazu
H
Usuda
Katsuo
K
Minato
Hiroshi
H
Sakuma
Tsutomu
T
D000368:Aged; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000473:pathology; D009361:Neoplasm Invasiveness; D018218:Neoplasms, Fibrous Tissue / Q000175:diagnosis* / Q000473:pathology; D020775:Thoracic Surgery, Video-Assisted