Steroid pathway and oestrone sulphate production in canine inflammatory mammary carcinoma.
Spontaneous canine mammary inflammatory carcinoma (IMC) shares epidemiologic, histopathologic and clinical characteristics with the inflammatory breast carcinoma (IBC) disease in humans. We have analysed the steroids levels in serum and in tissue homogenates of IMC, the expression of two of their receptors (androgen and beta-estrogen) and of three enzymes included in the steroidogenesis pathway (aromatase (CYP19A1), steroid sulphatase (STS) and estrogen sulfotransferase (EST)) trying to explain the specific accumulation of steroids in IMC tissues generating deposits in the form of lipid droplets whose presence can be attributed to steroids secreted by IMC cells. According to our working hypothesis, oestrone sulphate would be the main component of these lipid droplets. The presence of these steroid deposits would contribute to the intense proliferation and invasive behaviour of IMC and IBC, although their involvement in angiogenesis is yet to be demonstrated.
Sánchez-Archidona
Ana R
AR
Dpto. Producción Animal, Facultad de Veterinaria, UCM, 28040 Madrid, Spain.
Jiménez
María A
MA
Pérez-Alenza
Dolores
D
Silván
Gema
G
Illera
Juan C
JC
Peña
Laura
L
Dunner
Susana
S
D000818:Animals; D002277:Carcinoma / Q000378:metabolism* / Q000473:pathology; D004285:Dogs; D004970:Estrone / Q000031:analogs & derivatives* / Q000096:biosynthesis; D005260:Female; D015674:Mammary Neoplasms, Animal / Q000378:metabolism* / Q000473:pathology; D008413:Mastitis / Q000378:metabolism* / Q000473:pathology; D015398:Signal Transduction; D013256:Steroids / Q000097:blood / Q000378:metabolism*; D043266:Steryl-Sulfatase / Q000378:metabolism
D013256:Steroids; D004970:Estrone; D043266:Steryl-Sulfatase; C017296:estrone sulfate