title: Aberrant expression of keratinocyte growth factor receptor in ovarian surface epithelial cells of endometrioma.
abstract: Ovarian surface epithelial cells (OSEs) are considered to be the common source of endometrioma and epithelial ovarian cancer. The present study reveals that keratinocyte growth factor receptor (KGFR) messenger RNA was expressed in OSEs of endometriomas but not in those of normal ovaries, suggesting that autocrine KGF/KGFR and paracrine fibroblast growth factor 10/KGFR signaling loops may be involved with the proliferation in OSEs of endometrioma.
authors.affiliation: Department of Obstetrics and Gynecology, Tottori University School of Medicine, Yonago, Japan. tani4327@grape.med.tottori-u.ac.jp
authors.forename: Fuminori
authors.initials: F
authors.lastname: Taniguchi
authors.forename: Tasuku
authors.initials: T
authors.lastname: Harada
authors.forename: Tomio
authors.initials: T
authors.lastname: Iwabe
authors.forename: Yoko
authors.initials: Y
authors.lastname: Ohama
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Takenaka
authors.forename: Naoki
authors.initials: N
authors.lastname: Terakawa
mesh_terms: D002478:Cells, Cultured; D004715:Endometriosis / Q000235:genetics* / Q000378:metabolism; D004847:Epithelial Cells / Q000378:metabolism*; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D010049:Ovarian Diseases / Q000235:genetics* / Q000378:metabolism; D010053:Ovary / Q000378:metabolism*; D051497:Receptor, Fibroblast Growth Factor, Type 2 / Q000235:genetics* / Q000378:metabolism
chemical_list: D051497:Receptor, Fibroblast Growth Factor, Type 2; C065104:keratinocyte growth factor receptor