title: Noncardiac comorbidities of congenital heart disease in children.
abstract: BACKGROUND
  Noncardiac conditions may complicate heart disease care, contribute to the progression of the disease and alter the response to treatment. The aim of this prospective study was to evaluate the proportion of cardiac children with such significant conditions.
  
  
  METHODS
  Of the 1058 children with congenital heart disease primarily diagnosed during a 10-year-period in one hospital, we identified those patients who had significant congenital and acquired comorbidities.
  
  
  RESULTS
  Associated problems were diagnosed in 224 children (21.2%). Among them, 118 children (11.2%) had genetic or syndromic conditions, of which 38 had Trisomy 21. Six subspecialty areas accounted for the vast majority of the cases: neurology (n = 140), pulmonology (n = 36), orthopaedics (n = 26), nephro-urology (n = 19), gastroenterology (n = 14) and endocrinology (n = 13). The most frequent associated conditions were mental retardation, asthma, epilepsy and scoliosis. During the study period, death occurred in 46 of the children (4.3%) and was not related to the cardiac disease in 20 cases (1.9%).
  
  
  CONCLUSIONS
  A substantial proportion of children with congenital heart disease have significant noncardiac comorbidities. Close collaboration between paediatric cardiologists and paediatricians of other subspecialties is imperative to optimize care for these children.
authors.affiliation: Department of Pediatric Cardiology, Queen Fabiola Children's University Hospital, Free University of Brussels (ULB), Brussels, Belgium. martial.massin@huderf.be
authors.forename: Martial M
authors.initials: MM
authors.lastname: Massin
authors.forename: Iyawa
authors.initials: I
authors.lastname: Astadicko
authors.forename: Hugues
authors.initials: H
authors.lastname: Dessy
mesh_terms: D001530:Belgium / Q000453:epidemiology; D002648:Child; D015897:Comorbidity; D006330:Heart Defects, Congenital / Q000453:epidemiology*; D006801:Humans