title: Specialized inhibitory synaptic actions between nearby neocortical pyramidal neurons.
abstract: We found that, in the mouse visual cortex, action potentials generated in a single layer-2/3 pyramidal (excitatory) neuron can reliably evoke large, constant-latency inhibitory postsynaptic currents in other nearby pyramidal cells. This effect is mediated by axo-axonic ionotropic glutamate receptor-mediated excitation of the nerve terminals of inhibitory interneurons, which connect to the target pyramidal cells. Therefore, individual cortical excitatory neurons can generate inhibition independently from the somatic firing of inhibitory interneurons.
authors.affiliation: Department of Neuroscience, Research Institute of Environmental Medicine, Nagoya University, Nagoya 464-8601, Japan.
authors.forename: Ming
authors.initials: M
authors.lastname: Ren
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Yoshimura
authors.forename: Naoki
authors.initials: N
authors.lastname: Takada
authors.forename: Shoko
authors.initials: S
authors.lastname: Horibe
authors.forename: Yukio
authors.initials: Y
authors.lastname: Komatsu
mesh_terms: D000200:Action Potentials; D000818:Animals; D001369:Axons / Q000378:metabolism; D004558:Electric Stimulation; D019706:Excitatory Postsynaptic Potentials; D018698:Glutamic Acid / Q000378:metabolism / Q000494:pharmacology; D053444:Inhibitory Postsynaptic Potentials; D007395:Interneurons / Q000502:physiology; D051379:Mice; D008810:Mice, Inbred C57BL; D009433:Neural Inhibition; D018408:Patch-Clamp Techniques; D017729:Presynaptic Terminals / Q000502:physiology; D017966:Pyramidal Cells / Q000502:physiology*; D018091:Receptors, AMPA / Q000502:physiology; D018092:Kainic Acid Receptors / Q000502:physiology; D013569:Synapses / Q000502:physiology*; D009435:Synaptic Transmission; D014793:Visual Cortex / Q000166:cytology / Q000502:physiology*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
chemical_list: D018698:Glutamic Acid; D018091:Receptors, AMPA; D018092:Kainic Acid Receptors; D005680:gamma-Aminobutyric Acid