[Estimation of L-selectin expression on neutrophils and level of soluble L-selectin form in serum of patient with chronic myelogenic leukemia].
The aim of this study was the estimation of L-selectin expression on PMN and concentration of sL-selectin in patients serum with chronic myelogenic leukemia. The results indicate the increased expression of L-selectin on isolated neutrophils from peripheral blood of patients with chronic myelogenic leukemia. A concentration of sL-selectin was also increased in patients serum with chronic myelogenic leukemia. High concentration of L-selectin on PMN makes binding neoplastic cells easier. Increased level of sL-selectin might activate of the adhesion process in patients with chronic myelogenic leukemia. High expression of L-selectin on PMN may be a response to higher levels of TNF-alpha in serum blood patients with chronic myelogenic leukemia.
Kiersnowska-Rogowska
Beata
B
Klinika Hematologii Akademii Medycznej, w Białymstoku.
Izycka
Aneta
A
Jabłońska
Ewa
E
Rogowski
Franciszek
F
Parfieńczyk
Adam
A
D002448:Cell Adhesion / Q000502:physiology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D019041:L-Selectin / Q000097:blood*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000378:metabolism*; D012016:Reference Values; D044967:Serum / Q000737:chemistry; D012995:Solubility; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D015854:Up-Regulation
D014409:Tumor Necrosis Factor-alpha; D019041:L-Selectin