title: Sodium channel blockers.
authors.affiliation: Discovery Research, Purdue Pharma L.P., 6 Cedar Brook Drive, Cranbury, New Jersey 08512, USA. don.kyle@pharma.com
authors.forename: Donald J
authors.initials: DJ
authors.lastname: Kyle
authors.forename: Victor I
authors.initials: VI
authors.lastname: Ilyin
mesh_terms: D000700:Analgesics / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D000779:Anesthetics, Local / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D000927:Anticonvulsants / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D001593:Benzyl Compounds / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D003517:Cyclopentanes / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D015640:Ion Channel Gating; D010146:Pain / Q000188:drug therapy / Q000378:metabolism* / Q000503:physiopathology; D010523:Peripheral Nervous System Diseases / Q000188:drug therapy / Q000378:metabolism* / Q000503:physiopathology; D011743:Pyrimidines / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D012664:Semicarbazones / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D026941:Sodium Channel Blockers / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D015222:Sodium Channels / Q000145:classification / Q000187:drug effects* / Q000502:physiology
chemical_list: C514016:2-(4-(4-chloro-2-fluorophenoxy)phenyl)pyrimidine-4-carboxamide; D000700:Analgesics; D000779:Anesthetics, Local; D000889:Anti-Arrhythmia Agents; D000927:Anticonvulsants; D001593:Benzyl Compounds; D003517:Cyclopentanes; D011743:Pyrimidines; D012664:Semicarbazones; D026941:Sodium Channel Blockers; D015222:Sodium Channels; C509553:trans-N-((2'-(aminosulfonyl)biphenyl-4-yl)methyl)-N-methyl-N'-(4-(trifluoromethoxy)benzyl)cyclopentane-1,2-dicarboxamide; C119606:4-(4-fluorophenoxy)benzaldehyde semicarbazone