title: Thyrotropin releasing hormone (TRH) may preserve pancreatic islet cell function: potential role in the treatment of diabetes mellitus.
abstract: Thyrotropin Releasing Hormone (TRH), first identified in the hypothalamus as a regulator of the Pituitary-Thyroid axis, has also been found in the beta-cell of the pancreas co-localised with insulin. The significance of this association is emphasised by the report that the TRH knock-out (KO) mouse is hyperglycemic. These findings have led to speculation that TRH may have a physiologic role in the regulation of carbohydrate metabolism. To understand better the role of TRH in the pancreas, TRH was administered to rats rendered diabetic from streptozotocin damage to the islets of Langerhans. This resulted in almost complete normalisation of the profound hyperglycemia. TRH is capable of reversing Diabetes Mellitus (DM) in an experimental animal model, possibly by promoting neogenesis of beta cells through induction of adult stem cells in the pancreas. These studies point to a potential therapeutic role for TRH in the treatment of DM in man.
authors.affiliation: Roger Williams Hospital, Providence, Rhode Island, USA.
authors.forename: L G
authors.initials: LG
authors.lastname: Luo
authors.forename: Ivor
authors.initials: I
authors.lastname: Jackson
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D045744:Cell Line, Tumor / Q000378:metabolism; D003920:Diabetes Mellitus / Q000188:drug therapy*; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy; D004353:Drug Evaluation, Preclinical; D005544:Forecasting; D005786:Gene Expression Regulation; D006706:Homeostasis; D006801:Humans; D006943:Hyperglycemia / Q000188:drug therapy; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D007340:Insulinoma / Q000378:metabolism / Q000473:pathology; D007515:Islets of Langerhans / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D051379:Mice; D018345:Mice, Knockout; D010190:Pancreatic Neoplasms / Q000378:metabolism / Q000473:pathology; D011817:Rabbits; D051381:Rats; D013234:Stem Cells / Q000187:drug effects; D013311:Streptozocin; D013973:Thyrotropin-Releasing Hormone / Q000502:physiology* / Q000627:therapeutic use
chemical_list: D001786:Blood Glucose; D007328:Insulin; D013311:Streptozocin; D013973:Thyrotropin-Releasing Hormone