[The current opinion on inflammatory, biochemistry and hemostatic markers and factors in atherosclerosis. Part II].
Atherosclerosis remains the leading cause of morbidity and mortality in many countries. Recent studies have established an immuno-inflammatory theory of atherosclerosis where the process of atherosclerosis has a chronic, fibroproliferative character as an immuno-inflammatory response to factors that damage vessel endothelium. The development of coronary artery disease in subjects without traditional risk factors has prompted a search for new markers of the disease, which may improve primary prevention strategies. The relationship between markers of chronic inflammation and infection and development and progression of atherosclerotic may provide a basis for establishing new methods for causative treatment of cardiovascular diseases. The markers of endothelial damage and activation of inflammatory response have a prognostic value independent of traditional risk factors.
Rajtar
Renata
R
II Klinika Kardiologii Instytutu Kardiologii, Collegium Medicum Uniwersytetu Jagiellońskiego, Kraków.
Kloch
Małgorzata
M
Bober
Maria
M
Kolasińska-Kloch
Władysława
W
D000818:Animals; D050197:Atherosclerosis / Q000453:epidemiology / Q000276:immunology* / Q000628:therapy; D015415:Biomarkers / Q000378:metabolism*; D015984:Causality; D002986:Clinical Trials as Topic / Q000592:standards / Q000639:trends*; D015897:Comorbidity; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism*; D006801:Humans; D020138:Hyperhomocysteinemia / Q000378:metabolism; D007239:Infections / Q000453:epidemiology / Q000276:immunology; D007249:Inflammation / Q000453:epidemiology / Q000276:immunology*; D008954:Models, Biological; D017395:Plasminogen Activator Inhibitor 1 / Q000378:metabolism; D014527:Uric Acid / Q000378:metabolism*; D014657:Vasculitis / Q000453:epidemiology / Q000276:immunology; D014841:von Willebrand Factor / Q000378:metabolism*
D015415:Biomarkers; D005338:Fibrin Fibrinogen Degradation Products; D017395:Plasminogen Activator Inhibitor 1; D014841:von Willebrand Factor; D014527:Uric Acid