title: Baclofen-enhanced spinal cord stimulation and intrathecal baclofen alone for neuropathic pain: Long-term outcome of a pilot study.
abstract: In a previously published pilot study, we addressed the possibility to increase the effectiveness of spinal cord stimulation (SCS) applied for neuropathic pain by using adjunct pharmacological therapy. This combined treatment approach was a direct spin-off from animal experiments aiming at the exploration of transmitter and receptor mechanisms involved in the pain relieving effect of SCS. Out of 48 patients with neuropathic pain of peripheral origin responding poorly to SCS, seven received pumps for intrathecal baclofen (GABA-B receptor agonist) delivery together with SCS, and four had pumps alone. In order to assess the long-term effect a follow-up has been performed, with an average, total treatment time of 67 months. At the follow-up the remaining nine patients still enjoy about the same pain relief as initially, but with a mean, further dose increase of about 30%. This study demonstrates that a deficient SCS effect in neuropathic pain may be considerably improved by intrathecal baclofen administration, and that this enhanced effect persists for a long-time. On-going and future animal studies may provide new and even more efficient pharmaceutical candidates for such combined therapy.
authors.affiliation: Department of Neurosurgery, Karolinska University Hospital, SE-171 76 Stockholm, Sweden.
authors.forename: Göran
authors.initials: G
authors.lastname: Lind
authors.forename: Gastón
authors.initials: G
authors.lastname: Schechtmann
authors.forename: Jaleh
authors.initials: J
authors.lastname: Winter
authors.forename: Björn A
authors.initials: BA
authors.lastname: Meyerson
authors.forename: Bengt
authors.initials: B
authors.lastname: Linderoth
mesh_terms: D000328:Adult; D001418:Baclofen / Q000008:administration & dosage* / Q000627:therapeutic use; D004599:Electric Stimulation Therapy; D018755:GABA Agonists / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans; D007260:Infusion Pumps; D007278:Injections, Spinal; D008137:Longitudinal Studies; D008875:Middle Aged; D009437:Neuralgia / Q000503:physiopathology* / Q000628:therapy*; D010865:Pilot Projects; D013116:Spinal Cord / Q000503:physiopathology*; D016896:Treatment Outcome
chemical_list: D018755:GABA Agonists; D001418:Baclofen