title: Favorable periodontal healing of 1-wall infrabony defects after application of calcium phosphate cement wall alone or in combination with enamel matrix derivative: a pilot study with canine mandibles.
abstract: BACKGROUND
  Although various periodontal regenerative therapies are used, their effects on non-contained infrabony defects are unpredictable. Our previous studies showed that injectable, moldable, fast-setting calcium phosphate cement (CPC) promoted histocompatible periodontal healing in 3-wall intrabony defects. The present study evaluated healing patterns after surgical application of CPC walls with and without an enamel matrix derivative (EMD) in 1-wall infrabony defects in dogs.
  
  
  METHODS
  One-wall infrabony defects (5 x 5 x 4 mm) were created surgically on the mesial and distal sides of bilateral mandibular fourth premolars in four beagle dogs. After elevating a full-thickness flap, exposed root surfaces were planed thoroughly. The 16 defects were assigned randomly to one of the following experimental conditions: CPC, CPC+EMD, EMD, and open flap debridement (OFD). Ten weeks post-surgery, the animals were sacrificed, and histologic specimens were prepared for histomorphometric evaluation.
  
  
  RESULTS
  Defect sites treated with EMD only exhibited varying degrees of new cementum and new bone formation, whereas the OFD group presented only limited new cementum and bone formation. Defect sites where a CPC wall was implanted (CPC and CPC+EMD groups) revealed significantly greater regeneration of new bone and new cementum than in the EMD and OFD groups. No significant differences were observed between the CPC and CPC+EMD groups.
  
  
  CONCLUSIONS
  CPC walls with and without EMD promoted regeneration of alveolar bone and cementum in 1-wall infrabony defects. Space and stable wound healing are believed to be crucial for periodontal regeneration in non-contained infrabony defects.
authors.affiliation: Department of Periodontology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan. syoshi@denta.hal.kagoshima-u.ac.jp
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Shirakata
authors.forename: Takehiko
authors.initials: T
authors.lastname: Yoshimoto
authors.forename: Hisanori
authors.initials: H
authors.lastname: Goto
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Yonamine
authors.forename: Hideshi
authors.initials: H
authors.lastname: Kadomatsu
authors.forename: Motoharu
authors.initials: M
authors.lastname: Miyamoto
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Nakamura
authors.forename: Chie
authors.initials: C
authors.lastname: Hayashi
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Izumi
mesh_terms: D000818:Animals; D001843:Bone Cements / Q000627:therapeutic use*; D001861:Bone Regeneration / Q000187:drug effects; D018786:Bone Substitutes / Q000627:therapeutic use*; D002130:Calcium Phosphates / Q000627:therapeutic use*; D003746:Dental Enamel Proteins / Q000627:therapeutic use*; D004285:Dogs; D008297:Male; D008334:Mandible / Q000187:drug effects / Q000601:surgery*; D010510:Periodontal Diseases / Q000601:surgery; D010865:Pilot Projects; D014945:Wound Healing / Q000187:drug effects / Q000502:physiology*
chemical_list: D001843:Bone Cements; D018786:Bone Substitutes; D002130:Calcium Phosphates; D003746:Dental Enamel Proteins