title: [A case of small cell lung cancer under hemodialysis with chronic renal failure treated with amrubicin while measuring blood concentration of the drug].
abstract: We reported a case of small cell lung cancer treated with amrubicin while receiving hemodialysis. An 83-year-old man with chronic renal failure being treated by hemodialysis was admitted because of a left hilar mass. Small cell lung cancer with liver metastasis (cT2NOM1) was diagnosed. Two courses of chemotherapy with amrubicin resulted in partial response. Toxicity was relatively mild. We measured blood concentration of amrubicin during the first course of chemotherapy. There was no significant difference in blood cell and plasma concentration of amrubicin hydrochloride and amrubicinol between days when he received hemodialysis and when he did not receive hemodialysis. Thus, we considered that amrubicin hydrochloride may be a good candidate for the treatment of small cell lung cancer patients with chronic renal failure under hemodialysis.
authors.affiliation: Department of Respiratory Medicine, Koto Hospital.
authors.forename: Naoto
authors.initials: N
authors.lastname: Goto
authors.forename: Hideki
authors.initials: H
authors.lastname: Shibuya
authors.forename: Kei
authors.initials: K
authors.lastname: Har
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Hisada
mesh_terms: D000369:Aged, 80 and over; D018943:Anthracyclines / Q000097:blood* / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D018288:Carcinoma, Small Cell / Q000188:drug therapy* / Q000556:secondary; D004334:Drug Administration Schedule; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000628:therapy*; D008113:Liver Neoplasms / Q000556:secondary; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D006435:Renal Dialysis
chemical_list: D018943:Anthracyclines; D000970:Antineoplastic Agents; C055866:amrubicin