Flavonoids isolated from Draconis Resina.
One new chalcone, 4,6-dihydroxy-2-methoxy-3-methyldihydrochalcone (4), together with four known compounds, dammaradienol (1), (-)-5-methoxyflavan-7-ol (2), 5-methoxy-6-methyl-2-phenyl-7H-chromen-7-one (3), and dracorhodin (5), were isolated from Draconis Resina. The structures of these compounds were determined by spectral methods. Among these five compounds, compounds 1, 2, and 3 exhibited cytotoxicity against KB and HepG2 cells.
Shen
Chien-Chang
CC
National Research Institute of Chinese Medicine, Taipei, Taiwan, Republic of China.
Tsai
Show-Yinn
SY
Wei
Sai-Luh
SL
Wang
Shr-Ting
ST
Shieh
Bor-Jinn
BJ
Chen
Chien-Chih
CC
D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D047188:Chalcones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D031409:Dracaena / Q000737:chemistry*; D004365:Drugs, Chinese Herbal / Q000737:chemistry; D006801:Humans; D013058:Mass Spectrometry; D019906:Nuclear Magnetic Resonance, Biomolecular; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
D000970:Antineoplastic Agents; D047188:Chalcones; D004365:Drugs, Chinese Herbal