(S)-3-(Ammoniomethyl)-5-methylhexanoate (pregabalin).
The title compound, C(8)H(17)NO(2), exists as a zwitterion, adopting a propeller conformation. Molecules self-assemble to form a hydrogen-bonded layer parallel to the ab crystallographic plane connected by N+-H...O- and C-H...O- hydrogen bonds. These layers are stacked along the c axis and are stabilized by van der Waals interactions.
Venu
Nalivela
N
Centre for Excellence in Polymorphism, Dr Reddy's Laboratories Ltd, Bollaram, Hyderabad, India.
Vishweshwar
Peddy
P
Ram
Thaimattam
T
Surya
Devarakonda
D
Apurba
Bhattacharya
B
D000700:Analgesics / Q000737:chemistry; D014151:Anti-Anxiety Agents / Q000737:chemistry; D018360:Crystallography, X-Ray; D006860:Hydrogen Bonding; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D000069583:Pregabalin; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000737:chemistry
D000700:Analgesics; D014151:Anti-Anxiety Agents; D000069583:Pregabalin; D005680:gamma-Aminobutyric Acid