New oxypregnane glycosides from appetite suppressant herbal supplement Hoodia gordonii.
Hoodigosides A-K (1-11), eleven new oxypregnane glycosides and a previously reported oxypregnane glycoside P57AS3 were isolated from the aerial parts of Hoodia gordonii. The structures of these 12-O-beta-tigloyl isoramanone glycosides were determined on the basis of chemical evidence and extensive spectroscopic methods that include one-dimensional and two-dimensional NMR. Cytotoxicity and antioxidant activities of these compounds were tested in cell based assays where they were found to be inactive.
Pawar
Rahul S
RS
National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, University of Mississippi, University, MS 38677, USA.
Shukla
Yatin J
YJ
Khan
Shabana I
SI
Avula
Bharathi
B
Khan
Ikhlas A
IA
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D000975:Antioxidants / Q000494:pharmacology; D029062:Apocynaceae / Q000737:chemistry*; D001067:Appetite Depressants; D002240:Carbohydrate Sequence; D006027:Glycosides / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data; D021241:Spectrometry, Mass, Electrospray Ionization
D000970:Antineoplastic Agents; D000975:Antioxidants; D001067:Appetite Depressants; D006027:Glycosides