title: Frozen-section biopsy analysis for acute invasive fungal rhinosinusitis.
abstract: OBJECTIVE
  To evaluate sensitivity and specificity of frozen-section biopsy in the diagnosis of acute invasive fungal rhinosinusitis (AIFRS).
  
  
  METHODS
  Retrospective chart review of all patients treated for AIFRS at the University of Miami between 1993 and 2005. Twenty patients with the clinical diagnosis of AIFRS were identified. Histopathological data were collected to evaluate the use of frozen-section biopsy to diagnose the disease.
  
  
  RESULTS
  Permanent pathology sections were positive for AIFRS in all specimens. Frozen-section biopsies were positive for fungal features in all but five cases (four with Mucor and one with Aspergillus). High positive predictive values were found for both fungal types and for both sets of patients (bedside and intraoperative).
  
  
  CONCLUSIONS
  Frozen-section biopsy is a useful tool for rapid and effective diagnosis in patients with suspected AIFRS. A positive frozen-section result is highly predictive of invasive disease and merits prompt surgical intervention.
authors.affiliation: University of Miami/Jackson Memorial Hospital, Department of Otolaryngology/Head and Neck Surgery, Miami, FL 33136, USA. mghadiali@med.miami.edu
authors.forename: Murtaza T
authors.initials: MT
authors.lastname: Ghadiali
authors.forename: Nathan A
authors.initials: NA
authors.lastname: Deckard
authors.forename: Uzma
authors.initials: U
authors.lastname: Farooq
authors.forename: Frank
authors.initials: F
authors.lastname: Astor
authors.forename: Phillip
authors.initials: P
authors.lastname: Robinson
authors.forename: Roy R
authors.initials: RR
authors.lastname: Casiano
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000453:epidemiology; D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D001228:Aspergillosis / Q000175:diagnosis* / Q000453:epidemiology / Q000382:microbiology*; D002648:Child; D015897:Comorbidity; D003937:Diagnosis, Differential; D042241:Early Diagnosis; D005629:Frozen Sections / Q000379:methods*; D015658:HIV Infections / Q000453:epidemiology; D006801:Humans; D008875:Middle Aged; D009091:Mucormycosis / Q000175:diagnosis* / Q000453:epidemiology / Q000382:microbiology*; D009297:Nasal Mucosa / Q000382:microbiology / Q000473:pathology; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D012852:Sinusitis / Q000453:epidemiology / Q000382:microbiology* / Q000473:pathology*