title: Neonatal taurine administration modifies metabolic programming in male mice.
abstract: The semi-essential amino-acid taurine is involved in glucose homeostasis either in adults or in parental life. Taurine is currently used in neonatal life because it is added to milk formula for babies, and to parental solution for prematures. Here, it has been examined whether taurine administration in lactation modifies adult glucose metabolism. Neonatally taurine-treated mice (50 mg/kg body weight/day, for the first 21 days of life) as adults have lower basal glucose and iAUC after glucose loading curves in comparison with vehicle-treated mice, whereas iAUC following insulin loading curves, plasma lipids and malondialdehyde (MDA), an index of lipid peroxidation were not significantly changed. Thus, in rodents, neonatally administered taurine produces enduring effects in a way that could be advantageous for the control of glucose homoeostasis.
authors.affiliation: Istituto Superiore di Sanità, Roma, Italy.
authors.forename: Alberto
authors.initials: A
authors.lastname: Loizzo
authors.forename: Stefania
authors.initials: S
authors.lastname: Carta
authors.forename: Federico
authors.initials: F
authors.lastname: Bennardini
authors.forename: Rita
authors.initials: R
authors.lastname: Coinu
authors.forename: Stefano
authors.initials: S
authors.lastname: Loizzo
authors.forename: Irene
authors.initials: I
authors.lastname: Guarino
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Seghieri
authors.forename: Giovanni
authors.initials: G
authors.lastname: Ghirlanda
authors.forename: Flavia
authors.initials: F
authors.lastname: Franconi
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D005260:Female; D005947:Glucose / Q000378:metabolism*; D007328:Insulin / Q000378:metabolism; D007774:Lactation; D050356:Lipid Metabolism / Q000187:drug effects*; D015227:Lipid Peroxidation / Q000187:drug effects; D008055:Lipids / Q000097:blood; D051379:Mice; D013654:Taurine / Q000008:administration & dosage*
chemical_list: D007328:Insulin; D008055:Lipids; D013654:Taurine; D005947:Glucose