The role of complement and Toll-like receptors in organ transplantation.
The innate immune system not only participates in host defence but also contributes to the control of adaptive immune responses. Complement and Toll-like receptors (TLR) are key components of innate immunity. Emerging evidence suggests their activation is involved in all major aspects of transplantation. This paper reviews the current understanding of how the complement and TLR on impact transplant injury.
Lin
Tao
T
Department of Nephrology and Transplantation, King's College London School of Medicine at Guy's, King's College and St Thomas' Hospitals, London, UK.
Zhou
Wuding
W
Sacks
Steven H
SH
D003165:Complement System Proteins / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D015427:Reperfusion Injury / Q000276:immunology; D051193:Toll-Like Receptors / Q000276:immunology*; D014180:Transplantation; D014181:Transplantation Immunology; D014184:Transplantation, Homologous / Q000276:immunology
D051193:Toll-Like Receptors; D003165:Complement System Proteins