[Immunological aspects of postoperative analgesia after abdominal hysterectomy].
BACKGROUND
Prostaglandins modulate cytokine release though increases in cAMP, regulating interleukin-6 and interleukin-10. Ketoprofen inhibits cyclo-oxygenase activity and hence prostaglandin production.


OBJECTIVE
We hypothesized that ketoprofen would affect release of IL-6 and IL-10 and modulate the immune response.


METHODS
We have evaluated 40 women, divided into four groups by the model of postoperative pain treatment: control group (only opioid) and experimental group (combination of i.v. ketoprofen and opioid). Serum IL-6 and IL-10 were measured before surgery, 24 and 72 hours after skin incision. Due to days in hospital we detected temperature and severe complications.


RESULTS
IL-6 increased at 24h and normalized at 72h. In contrast IL-10 did not change significantly.


CONCLUSIONS
The two models of postoperative analgesia have both modulated immune response after abdominal hysterectomy in same way.
Tablov
B
B
Stavreva
S
S
Tablov
V
V
Popov
I
I
Konova
E
E
D000005:Abdomen / Q000601:surgery; D000328:Adult; D000698:Analgesia / Q000379:methods*; D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000627:therapeutic use; D016861:Cyclooxygenase Inhibitors / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007044:Hysterectomy / Q000379:methods*; D018836:Inflammation Mediators / Q000097:blood / Q000276:immunology*; D016753:Interleukin-10 / Q000097:blood / Q000276:immunology; D015850:Interleukin-6 / Q000097:blood / Q000276:immunology; D007660:Ketoprofen / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D010149:Postoperative Pain / Q000188:drug therapy* / Q000276:immunology; D011453:Prostaglandins / Q000097:blood / Q000276:immunology
D000701:Analgesics, Opioid; D016861:Cyclooxygenase Inhibitors; D018836:Inflammation Mediators; D015850:Interleukin-6; D011453:Prostaglandins; D016753:Interleukin-10; D007660:Ketoprofen