Exercise can prevent and even reverse adverse effects of androgen suppression treatment in men with prostate cancer.
Side effects accompanying androgen deprivation therapy (ADT), including sarcopenia, loss of bone mass and reduction in muscle strength, can compromise physical function, particularly in older patients. Exercise, specifically resistance training, may be an effective and cost-efficient strategy to limit or even reverse some of these adverse effects during and following therapy. In this review, we discuss common morphological and physiological ADT-related side effects or 'Androgen Deprivation and Sarcopenia-Related Disorders' and the existing clinical trials incorporating physical exercise in prostate cancer patients receiving active therapy. Further, training concepts and guidelines are provided for prescribing resistance exercise programs for this population.
Galvão
D A
DA
Vario Health Institute, School of Exercise, Biomedical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia. d.galvao@ecu.edu.au
Taaffe
D R
DR
Spry
N
N
Newton
R U
RU
D000726:Androgen Antagonists / Q000009:adverse effects* / Q000627:therapeutic use; D005081:Exercise Therapy; D006801:Humans; D008297:Male; D009140:Musculoskeletal Diseases / Q000139:chemically induced / Q000628:therapy*; D011471:Prostatic Neoplasms / Q000150:complications / Q000188:drug therapy*; D016896:Treatment Outcome
D000726:Androgen Antagonists