title: Investigation of mumps vaccine failures in Minsk, Belarus, 2001-2003.
abstract: The purpose of this study was to investigate mumps vaccine failures (VF) in a highly vaccinated population of Minsk, Belarus, and to investigate a possible role for virus strain-specific immunity. During our 3-year study period, 22 adults were admitted to the Infectious Diseases Hospital in Minsk with a diagnosis of mumps. A genotype H1 mumps virus (MuV) strain was identified in all patients. Of 15 patients from whom the paired sera were collected, 9 were confirmed to have been previously vaccinated. Serological examinations indicated primary VF in seven of these cases and secondary VF in two. Despite almost all vaccinated patients possessing MuV specific IgG, few possessed neutralizing antibody to the vaccine strain and titers were nominal. Importantly, none of the sera were able to neutralize a genotype H MuV strain. Our results demonstrate the importance of assaying for neutralizing antibody and support the assertion that antigenic differences between wild type and vaccine MuV strains may play a role in cases of breakthrough infection in vaccinees.
authors.affiliation: State Research Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk Region, Russia. ignat@vector.nsc.ru
authors.forename: Alena V
authors.initials: AV
authors.lastname: Atrasheuskaya
authors.forename: Elena M
authors.initials: EM
authors.lastname: Blatun
authors.forename: Michail V
authors.initials: MV
authors.lastname: Kulak
authors.forename: Alina
authors.initials: A
authors.lastname: Atrasheuskaya
authors.forename: Igor A
authors.initials: IA
authors.lastname: Karpov
authors.forename: Steven
authors.initials: S
authors.lastname: Rubin
authors.forename: George M
authors.initials: GM
authors.lastname: Ignatyev
mesh_terms: D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D000956:Antigens, Viral / Q000276:immunology; D001483:Base Sequence; D005260:Female; D005838:Genotype; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D008969:Molecular Sequence Data; D009107:Mumps / Q000276:immunology* / Q000821:virology*; D009108:Mumps Vaccine / Q000276:immunology*; D009109:Mumps virus / Q000145:classification / Q000235:genetics / Q000276:immunology* / Q000302:isolation & purification*; D009500:Neutralization Tests; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics; D002094:Republic of Belarus; D017422:Sequence Analysis, DNA; D012698:Serologic Tests; D012703:Serotyping
chemical_list: D000914:Antibodies, Viral; D000956:Antigens, Viral; D007074:Immunoglobulin G; D009108:Mumps Vaccine; D012367:RNA, Viral