title: Hypoglycemic and hypolipidemic effects of fresh leaf aqueous extract of Cymbopogon citratus Stapf. in rats.
abstract: The present study was designed to investigate the hypoglycemic and hypolipidemic effects of the single, daily oral dosing of 125-500 mg/kg of fresh leaf aqueous extract of Cymbopogon citratus Stapf. (CCi) in normal, male Wistar rats for 42 days. The average weights of rats per group were taken at 2 weeks interval for 42 days. On day 43, blood samples from the rats were collected for fasting plasma glucose (FPG), total cholesterol, triglycerides, low-density lipoproteins (LDL-c), very low-density lipoprotein (VLDL-c) and high-density lipoprotein (HDL-c) assays through cardiac puncture under halothane anesthesia. Acute oral dose toxicity study of CCi was also conducted using limit dose test of the Up and Down Procedure statistical program (AOT425StatPgm, Version 1.0) at a dose of 5000 mg/kg body weight/oral route. Our results showed CCi to lower FPG and lipid parameters dose dependently (p<0.05) while raising the plasma HDL-c level (p<0.05) in same dose-related fashion but with no effect on plasma triglycerides level (p>0.05). Results of acute oral toxicity showed CCi to be of low toxicity and as such could be considered relatively safe on acute exposure. Thus, confirming its folkloric use and safety in suspected Type 2 diabetic patients.
authors.affiliation: Department of Pharmacology, Lagos State University College of Medicine, Ikeja, Lagos State, Nigeria. adeneye2001@yahoo.com
authors.forename: Adejuwon Adewale
authors.initials: AA
authors.lastname: Adeneye
authors.forename: Esther Oluwatoyin
authors.initials: EO
authors.lastname: Agbaje
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D002784:Cholesterol / Q000097:blood; D015243:Cholesterol, VLDL / Q000097:blood; D031743:Cymbopogon / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D005215:Fasting / Q000097:blood; D006801:Humans; D007003:Hypoglycemia / Q000097:blood / Q000517:prevention & control; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D000960:Hypolipidemic Agents / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D009549:Nigeria; D010936:Plant Extracts / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D023382:Toxicity Tests, Acute / Q000379:methods
chemical_list: D001786:Blood Glucose; D015243:Cholesterol, VLDL; D007004:Hypoglycemic Agents; D000960:Hypolipidemic Agents; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D010936:Plant Extracts; D002784:Cholesterol