title: Percutaneous laser ablation of unresectable primary and metastatic adrenocortical carcinoma.
abstract: OBJECTIVE
  To evaluate the feasibility, safety, and clinical benefits of percutaneous laser ablation (PLA) in patients with unresectable primary and metastatic adrenocortical carcinoma (ACC).
  
  
  METHODS
  Four patients with hepatic metastases from ACC and a Cushing's syndrome underwent ultrasound-guided PLA. In one case the procedure was performed also on the primary tumor.
  
  
  RESULTS
  After three sessions of PLA, the primary tumor of 15 cm was ablated by 75%. After 1-4 (median 1) sessions of PLA, five liver metastases ranging from 2 to 5 cm were completely ablated, while the sixth tumor of 12 cm was ablated by 75%. There were no major complications. Treatment resulted in an improvement of performance status and a reduction of the daily dosage of mitotane in all patients. The three patients with liver metastases presented a marked decrease of 24-h urine cortisol levels, an improved control of hypertension and a mean weight loss of 2.8 kg. After a median follow-up after PLA of 27.0 months (range, 9-48 months), two patients have died of tumor progression, while two other patients remain alive and free of disease.
  
  
  CONCLUSIONS
  Percutaneous laser ablation is a feasible, safe and well tolerated procedure for the palliative treatment of unresectable primary and metastatic ACC. Further study is required to evaluate the impact of PLA on survival.
authors.affiliation: Regina Apostolorum Hospital, Department of Diagnostic Imaging and Interventional Radiology, Via San Francesco 50, Albano Laziale, Rome 00041, Italy. claudiomaurizio.pacella@fastwebnet.it
authors.forename: Claudio M
authors.initials: CM
authors.lastname: Pacella
authors.forename: Roberto
authors.initials: R
authors.lastname: Stasi
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Bizzarri
authors.forename: Sara
authors.initials: S
authors.lastname: Pacella
authors.forename: Filomena Maria
authors.initials: FM
authors.lastname: Graziano
authors.forename: Rinaldo
authors.initials: R
authors.lastname: Guglielmi
authors.forename: Enrico
authors.initials: E
authors.lastname: Papini
mesh_terms: D000306:Adrenal Cortex Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D018268:Adrenocortical Carcinoma / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use; D003131:Combined Modality Therapy; D018450:Disease Progression; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D053685:Laser Therapy / Q000379:methods*; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000556:secondary / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D008939:Mitotane / Q000627:therapeutic use; D010166:Palliative Care; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D018931:Antineoplastic Agents, Hormonal; D008939:Mitotane