Prostate and lymph node proton magnetic resonance (MR) spectroscopic imaging with external array coils at 3 T to detect recurrent prostate cancer after radiation therapy.
In a patient suspected of having recurrent prostate cancer after radiation therapy, we demonstrate the feasibility of noninvasive proton magnetic resonance spectroscopic (1H-MRS) imaging of the prostate and a lymph node at 3 T using a matrix of external surface coils. Written informed consent was obtained from the patient. With 1H-MRS imaging, high choline with low citrate signal was observed in the prostate, and in the lymph node a signal of choline-containing compounds was identified. The tissue level of the compounds in the enlarged lymph node was estimated to be 8.1 mmol/kg water. Subsequent histopathological analysis of systematic transrectal ultrasound-guided prostate biopsy and computed tomography-guided biopsy of the lymph node confirmed the presence of prostate cancer in both.
Heijmink
Stijn W T P J
SW
Department of Radiology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands. s.heijmink@rad.umcn.nl
Scheenen
Tom W J
TW
Fütterer
Jurgen J
JJ
Klomp
Dennis W J
DW
Heesakkers
Roel A M
RA
Hulsbergen-van de Kaa
Christina A
CA
van Lin
Emile N J Th
EN
Heerschap
Arend
A
Barentsz
Jelle O
JO
D000230:Adenocarcinoma / Q000473:pathology* / Q000532:radiotherapy; D000368:Aged; D002794:Choline / Q000378:metabolism; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis / Q000473:pathology; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D009367:Neoplasm Staging; D011471:Prostatic Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000532:radiotherapy
D002794:Choline