title: Influence of the type of vehicle and limit of obturation on apical and periapical tissue response in dogs' teeth after root canal filling with mineral trioxide aggregate.
abstract: The purpose of this study was to investigate the influence of the type of vehicle (distilled water or propyleneglycol) on the response of apical tissues of dogs' teeth after root canal filling with mineral trioxide aggregate (MTA) at two different limits. Forty roots of incisors and premolars of two adult dogs were used. After pulpectomy, the root canals were prepared biomechanically, and the roots had the apical cemental barrier penetrated with a #15 K-file and widened to a #25 K-file. The root canals were assigned to four groups according to the vehicle used for MTA (ProRoot-MTA; Tulsa Dental, Tulsa, OK) preparation and the limit of root canal filling: group 1, filling with MTA/distilled water to the limit of the cemental canal; group 2, overfilling with MTA/distilled water; group 3, filling with MTA/propyleneglycol to the limit of the cemental canal; and group 4, overfilling with MTA/propyleneglycol. The animals were killed by anesthetic overdose 90 days after endodontic treatment, and the anatomic pieces were prepared for histomorphological analysis. The sections were stained with hematoxylin and eosin and Brown and Brenn techniques. The results showed that MTA pastes prepared with either distilled water or propyleneglycol as vehicles had similar biological behavior (p > 0.05); root fillings placed at the cemental canal limit showed better results than the overfillings (p = 0.01), and MTA/propyleneglycol paste was more easily placed into the root canals than MTA/distilled water paste.
authors.affiliation: Department of Restorative Dentistry, School of Dentistry of Araçatuba, São Paulo, State University UNESP, Araçatuba, SP, Brazil. rholland@foa.unesp.br <rholland@foa.unesp.br>
authors.forename: Roberto
authors.initials: R
authors.lastname: Holland
authors.forename: Lucimar
authors.initials: L
authors.lastname: Mazuqueli
authors.forename: Valdir
authors.initials: V
authors.lastname: de Souza
authors.forename: Sueli Satomi
authors.initials: SS
authors.lastname: Murata
authors.forename: Eloi
authors.initials: E
authors.lastname: Dezan Júnior
authors.forename: Patrícia
authors.initials: P
authors.lastname: Suzuki
mesh_terms: D017607:Aluminum Compounds / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D017610:Calcium Compounds / Q000008:administration & dosage / Q000494:pharmacology*; D003739:Dental Cementum / Q000187:drug effects; D004285:Dogs; D004338:Drug Combinations; D005119:Extravasation of Diagnostic and Therapeutic Materials; D010087:Oxides / Q000008:administration & dosage / Q000494:pharmacology*; D010486:Periapical Tissue / Q000187:drug effects*; D014677:Pharmaceutical Vehicles; D019946:Propylene Glycol; D011670:Pulpectomy; D012387:Root Canal Filling Materials / Q000494:pharmacology*; D012389:Root Canal Obturation / Q000379:methods*; D017640:Silicates / Q000008:administration & dosage / Q000494:pharmacology*; D019227:Tooth Apex / Q000187:drug effects*; D014867:Water
chemical_list: D017607:Aluminum Compounds; D017610:Calcium Compounds; D004338:Drug Combinations; D010087:Oxides; D014677:Pharmaceutical Vehicles; D012387:Root Canal Filling Materials; D017640:Silicates; C086631:mineral trioxide aggregate; D014867:Water; D019946:Propylene Glycol