title: Insertion sequence 1515 in the ply gene of a type 1 clinical isolate of Streptococcus pneumoniae abolishes pneumolysin expression.
abstract: A serotype 1 Streptococcus pneumoniae strain isolated by blood culture from a woman with pneumonia was found to harbor insertion sequence (IS) 1515 in the pneumolysin gene, abolishing pneumolysin expression. To our knowledge, this is the first report of an IS in the pneumolysin gene of S. pneumoniae.
authors.affiliation: Laboratoire de Bactériologie-Virologie-Hygiène, EA 3175, CHU DUPUYTREN, 2 avenue Martin Luther King, 87042 Limoges cedex, France. fabien.garnier@unilim.fr
authors.forename: Fabien
authors.initials: F
authors.lastname: Garnier
authors.forename: Rajendra Prasad
authors.initials: RP
authors.lastname: Janapatla
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Charpentier
authors.forename: Geoffrey
authors.initials: G
authors.lastname: Masson
authors.forename: Carole
authors.initials: C
authors.lastname: Grélaud
authors.forename: Jean François
authors.initials: JF
authors.lastname: Stach
authors.forename: François
authors.initials: F
authors.lastname: Denis
authors.forename: Marie-Cécile
authors.initials: MC
authors.lastname: Ploy
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics; D004251:DNA Transposable Elements / Q000235:genetics*; D005260:Female; D015964:Gene Expression Regulation, Bacterial; D006801:Humans; D008969:Molecular Sequence Data; D016254:Mutagenesis, Insertional; D011018:Pneumonia, Pneumococcal / Q000382:microbiology; D013296:Streptococcus pneumoniae / Q000235:genetics*; D013301:Streptolysins / Q000235:genetics*
chemical_list: D001426:Bacterial Proteins; D004251:DNA Transposable Elements; D013301:Streptolysins; C032290:plY protein, Streptococcus pneumoniae