title: [Perioperative anti-inflammatory drug use: which evidences for their utility and safety?].
abstract: OBJECTIVE
  To bring together the most recent evidences concerning the utility and safety of perioperative anti-inflammatory drug use.
  
  
  METHODS
  References were obtained from computerised bibliographic data banks (MeSH terms: NSAIDs, coxibs, steroids, surgery, anaesthesia), followed by manual search.
  
  
  RESULTS
  NSAIDs, coxibs and steroids used alone or in association have been demonstrated to be effective for relieving postoperative pain. However, the benefits of perioperative anti-inflammatory drug use may go beyond the postoperative analgesia. In some cases, anti-inflammatory drugs have been shown to decrease the incidence of morphine side-effects, postoperative nausea and vomiting or to improve postoperative recovery. Nevertheless, NSAIDs have been found to be a risk factor of severe postoperative bleeding requiring surgical haemostasis after some surgical procedures. In contrast, coxibs have been shown to promote arterial thrombosis after others surgical procedures.
authors.affiliation: Département d'anesthésie-réanimation, hôpital Tenon, Paris, France. emmanuel.marret@tnn.ap-hop-paris.fr <emmanuel.marret@tnn.ap-hop-paris.fr>
authors.forename: E
authors.initials: E
authors.lastname: Marret
authors.forename: F
authors.initials: F
authors.lastname: Bonnet
mesh_terms: D000893:Anti-Inflammatory Agents / Q000009:adverse effects* / Q000627:therapeutic use*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000627:therapeutic use; D002319:Cardiovascular System / Q000187:drug effects; D004064:Digestive System / Q000187:drug effects; D006801:Humans; D007239:Infections / Q000139:chemically induced; D007668:Kidney / Q000187:drug effects; D019990:Perioperative Care; D012307:Risk Factors
chemical_list: D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal