[Intravascular laser irradiation of blood in the treatment of patients with bronchial asthma].
OBJECTIVE
To investigate action of intravascular laser blood irradiation (ILBI) on production of active oxygen forms (AOF) in patients with bronchial asthma (BA).


METHODS
The trial included 59 BA patients aged 20 to 60 years (mean age 40.2 +/- 3.1 years). AOF generation in whole blood was registered with luminol-dependent chemiluminescence (CL). Basic therapy was given to 42 patients. ILBI was added to basic therapy in 17 patients.


RESULTS
. CL of whole blood in BA patients depended on severity of inflammation. BA patients with intensive CL exposed to ILBI retained free radical oxidation defects and the disease symptoms. In low intensity of blood CL, ILBI activated A OF generation and raised treatment effectiveness.


CONCLUSIONS
ILBI raises AOF production in the whole blood of BA patients. CL registration can be used for validation of ILBI administration in BA patients and control of effectiveness of laser therapy.
Farkhutdinov
U R
UR
D001249:Asthma / Q000097:blood / Q000378:metabolism / Q000532:radiotherapy*; D001769:Blood / Q000528:radiation effects*; D005260:Female; D006801:Humans; D028022:Low-Level Light Therapy / Q000379:methods*; D008163:Luminescent Measurements; D008297:Male; D017382:Reactive Oxygen Species / Q000097:blood*; D016896:Treatment Outcome
D017382:Reactive Oxygen Species