title: [Cognitive dysfunction in patients with systemic lupus erythemathosus with or without antiphospholipid antibodies].
abstract: BACKGROUND
  Impairment of cognitive functions is one of the neuropsychiatric symptoms of systemic lupus erythemathosus (SLE), the association of which with secondary antiphospholipid syndrome is often mentioned in the literature on the subject. Ethiology has not yet been fully clarified.
  
  
  METHODS
  The aim of the study was to compare the "mini-mental state examination" (MMSE) outcomes in SLE patients with and without antiphospholipid antibodies (APA).
  
  
  RESULTS
  Probands producing APA presented with significantly worse results in MMSE when compared to patients without these antibodies. There was no difference between patients with antisphospholipid syndrome and those with APA only.
  
  
  CONCLUSIONS
  Our study supports the notion that association of SLE with APA (not only with antiphospholipid syndrome) aggravates the deterioration of cognitive functions. MMSE test should not be omitted in the follow-up of SLE patients.
authors.affiliation: II. Interní klinika Lékarské fakulty UK a FN Hradec Králové. cibickova@seznam.cz
authors.forename: L
authors.initials: L
authors.lastname: Cibicková
authors.forename: T
authors.initials: T
authors.lastname: Soukup
authors.forename: E
authors.initials: E
authors.lastname: Cermáková
authors.forename: P
authors.initials: P
authors.lastname: Bradna
authors.forename: Z
authors.initials: Z
authors.lastname: Hrncír
mesh_terms: D000368:Aged; D016736:Antiphospholipid Syndrome / Q000150:complications* / Q000276:immunology; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000276:immunology / Q000523:psychology*; D008297:Male; D008609:Mental Status Schedule; D008875:Middle Aged