A review of association and linkage studies for genetical analyses of learning disorders.
Learning disorders (LD) commonly comprise of a heterogeneous group of disorders manifested by unexpected problems in some children's experiences in the academic performance arena. These problems especially comprise of a variety of disorders which may be subclassified to attention-deficit hyperactivity disorder (ADHD), reading disability (RD), specific language impairment (SLI), speech-sound disorder (SSD), and dyspraxia. The aim of this review is to summarize the current molecular studies and some of the most exciting recent developments in molecular genetic research on LD. The findings for the association and linkage of LD with candidate genes will help to set the research agendas for future studies to follow.
Caylak
Emrah
E
Department of Biochemistry and Clinical Biochemistry, Firat University, School of Medicine, Elazig, Turkey. emrah333@hotmail.com
D001072:Apraxias / Q000235:genetics; D001289:Attention Deficit Disorder with Hyperactivity / Q000235:genetics; D004410:Dyslexia / Q000235:genetics; D051858:Forkhead Transcription Factors / Q000235:genetics; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D006801:Humans; D007806:Language Disorders / Q000235:genetics; D007859:Learning Disabilities / Q000235:genetics*; D044302:Receptor, Serotonin, 5-HT1B / Q000235:genetics; D018341:Receptors, Adrenergic, alpha-2 / Q000235:genetics; D050638:Receptors, Dopamine D4 / Q000235:genetics; D013064:Speech Disorders / Q000235:genetics
C547768:ADRA2A protein, human; C465448:FOXP2 protein, human; D051858:Forkhead Transcription Factors; C470302:HTR1B protein, human; D044302:Receptor, Serotonin, 5-HT1B; D018341:Receptors, Adrenergic, alpha-2; D050638:Receptors, Dopamine D4