title: Mycoplasmal membrane protein p37 promotes malignant changes in mammalian cells.
abstract: Evidence of Mycoplasma hyorhinis infection in human gastric cancer tissues has been found in previous work. In this study, we demonstrate that the expression of p37, a membrane lipoprotein of M. hyorhinis, in mammalian cells induces antisenescence, enhances clonogenicity in soft agar, and co-operates with human epidermal growth factor receptor-related 2 to inhibit cell adhesion. Conversely, truncated p37 protein, with the first 28 amino acids deleted from its N terminal, promotes cell senescence. Taken together, our findings suggest that p37 promotes malignant changes in mammalian cells. With the identification of this molecular component, which is responsible for mycoplasma malignancy-promoting activity, it is possible that a better understanding of the relationship between M. hyorhinis infection and human gastric cancers will lead to novel diagnostics and therapeutics.
authors.affiliation: Department of Biochemistry and Molecular Biology, Peking University School of Oncology and Beijing Cancer Hospital and Institute, 52 Fu-Cheng Road, Haidian District, Beijing, 100036 People's Republic of China.
authors.forename: Wenbin
authors.initials: W
authors.lastname: Liu
authors.forename: Tingting
authors.initials: T
authors.lastname: Ren
authors.forename: Beihai
authors.initials: B
authors.lastname: Jiang
authors.forename: Manman
authors.initials: M
authors.lastname: Gong
authors.forename: Chengchao
authors.initials: C
authors.lastname: Shou
mesh_terms: D001426:Bacterial Proteins / Q000502:physiology*; D002448:Cell Adhesion; D045744:Cell Line, Tumor; D002471:Cell Transformation, Neoplastic; D016922:Cellular Senescence; D006801:Humans; D008565:Membrane Proteins / Q000502:physiology*; D009175:Mycoplasma Infections / Q000150:complications; D045790:Mycoplasma hyorhinis / Q000472:pathogenicity*; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000502:physiology; D013274:Stomach Neoplasms / Q000209:etiology
chemical_list: D001426:Bacterial Proteins; D008565:Membrane Proteins; D018719:Erb-b2 Receptor Tyrosine Kinases