New understanding of the group A Streptococcus pathogenesis cycle.
Group A Streptococcus (GAS) has long been recognized as a human pathogen causing an exceptionally broad range of infections. Despite intense research, however, the molecular mechanisms of GAS disease remain unclear. Recently, many important discoveries have been made that shed light on GAS pathogenesis and open exciting avenues for future research. Advances in genome sequencing, microarray technology and proteomic analysis, in combination with the development of more suitable animal models, have markedly increased our knowledge of the mechanisms underlying GAS pathogenesis. The information gained from these studies will translate into improved diagnostics and new targets for therapeutic drugs and vaccines.
Tart
Anne H
AH
Center for Molecular and Translational Human Infectious Diseases Research, The Methodist Hospital Research Institute, and Department of Pathology, The Methodist Hospital, 6565 Fannin Street B490, Houston, TX 77030, USA.
Walker
Mark J
MJ
Musser
James M
JM
D002353:Carrier State / Q000382:microbiology; D005838:Genotype; D006801:Humans; D012703:Serotyping; D013290:Streptococcal Infections / Q000503:physiopathology*; D013297:Streptococcus pyogenes / Q000235:genetics / Q000378:metabolism / Q000472:pathogenicity*; D037521:Virulence Factors
D037521:Virulence Factors