title: Biologic grafts and synthetic meshes in pelvic reconstructive surgery.
abstract: Despite the lack of evidence, augmenting pelvic organ prolapse surgery with biologic graft or synthetic mesh is increasing. The objective of this review is to examine the available grafts and meshes and discuss the current data addressing the use of these implants in correction of apical, anterior, and posterior prolapse. Most of the studies are retrospective with few randomized controlled trials. There is level I evidence suggesting that repair of apical prolapse with abdominal sacral colpopexy using synthetic mesh results in improved outcomes. However, most of the data concerning graft or mesh incorporation in anterior or posterior repairs do not support augmentation with prosthesis.
authors.affiliation: Department of Obstetrics Gynecology, Cleveland Clinic, Cleveland, OH 44195, USA.
authors.forename: Chi Chiung Grace
authors.initials: CC
authors.lastname: Chen
authors.forename: Beri
authors.initials: B
authors.lastname: Ridgeway
authors.forename: Marie Fidela R
authors.initials: MF
authors.lastname: Paraiso
mesh_terms: D001672:Biocompatible Materials; D005260:Female; D013509:Gynecologic Surgical Procedures / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D010388:Pelvis / Q000601:surgery*; D019736:Prostheses and Implants; D019651:Plastic Surgery Procedures / Q000295:instrumentation / Q000379:methods*; D013526:Surgical Mesh; D016896:Treatment Outcome; D014596:Uterine Prolapse / Q000601:surgery*
chemical_list: D001672:Biocompatible Materials