Fumimycin: a peptide deformylase inhibitor with an unusual skeleton produced by Aspergillus fumisynnematus.
Fumimycin, an unusual metabolite incorporating an unusual alanine unit linked to a phenyl group at the alpha-carbon with both lactone and amide moieties, was isolated from cultures of Aspergillus fumisynnematus. Its structure was established by spectral analysis. Fumimycin was found to inhibit Staphylococcus aureus peptide deformylase with an IC50 value of 4.1 microM and also showed antibacterial activity against S. aureus.
Kwon
Yun-Ju
YJ
Functional Metabolite Research Center, Korea Research Institute of Bioscience and Biotechnology, Yusong, Daejeon 305-806, Korea.
Sohn
Mi-Jin
MJ
Zheng
Chang-Ji
CJ
Kim
Won-Gon
WG
D000581:Amidohydrolases / Q000037:antagonists & inhibitors*; D001230:Aspergillus / Q000737:chemistry* / Q000378:metabolism*; D001572:Benzofurans / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D015394:Molecular Structure; D013211:Staphylococcus aureus / Q000201:enzymology
D001572:Benzofurans; C522224:fumimycin; D000581:Amidohydrolases; C084507:peptide deformylase