ALOX5AP gene variants and risk of coronary artery disease: an angiography-based study.
The aim of this study was to explore the role of variants of the gene encoding arachidonate 5-lipoxygenase-activating protein (ALOX5AP) as possible susceptibility factors for coronary artery disease (CAD) and myocardial infarction (MI) in patients with or without angiographically proven CAD. A total of 1431 patients with or without angiographically documented CAD were examined simultaneously for seven ALOX5AP single-nucleotide polymorphisms, allowing reconstruction of the at-risk haplotypes (HapA and HapB) previously identified in the Icelandic and British populations. Using a haplotype-based approach, HapA was not associated with either CAD or MI. On the other hand, HapB and another haplotype within the same region (that we named HapC) were significantly more represented in CAD versus CAD-free patients, and these associations remained significant after adjustment for traditional cardiovascular risk factors by logistic regression (HapB: odds ratio (OR) 1.67, 95% confidence interval (CI) 1.04-2.67; P=0.032; HapC: OR 2.41, 95% CI 1.09-5.32; P=0.030). No difference in haplotype distributions was observed between CAD subjects with or without a previously documented MI. Our angiography-based study suggests a possible modest role of ALOX5AP in the development of the atheroma rather than in its late thrombotic complications such as MI.
Girelli
Domenico
D
Department of Clinical and Experimental Medicine, University of Verona, Verona, Italy. domenico.girelli@univr.it
Martinelli
Nicola
N
Trabetti
Elisabetta
E
Olivieri
Oliviero
O
Cavallari
Ugo
U
Malerba
Giovanni
G
Busti
Fabiana
F
Friso
Simonetta
S
Pizzolo
Francesca
F
Pignatti
Pier Franco
PF
Corrocher
Roberto
R
D058927:5-Lipoxygenase-Activating Proteins; D002352:Carrier Proteins / Q000235:genetics*; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000150:complications / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
D058927:5-Lipoxygenase-Activating Proteins; C548592:ALOX5AP protein, human; D002352:Carrier Proteins; D008565:Membrane Proteins