[Phosphodiesterase inhibitors in clinical practice. The present and the future. Part I].
Type 5 phosphodiesterase inhibitors (5-PDEI), which have been applied as the basic medication for erectile dysfunction, are now being studied in various areas of clinical medicine (pulmonology, cardiology, gastroenterology, gynecology etc.) This systematic literature review is dedicated to 5-PDEI, the state of the problem, the prospects of clinical application of sildenafil, and is based upon 450 literature sources from MEDLINE database (from 1954 to June 2006) and the Cochrane Collaboration database (from 1977 to March 2005) found by key words sildenafil, phosphodiesterase, and 5-PDEI. The issues of physiology and pathophysiology of 5-PDEI, the historical background of their creation, the appropriateness and efficacy of sildenafil in pulmonary arterial hypertension are considered in Part I of the review.
Baksheev
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Kolomoets
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D015106:3',5'-Cyclic-GMP Phosphodiesterases / Q000378:metabolism*; D000701:Analgesics, Opioid / Q000378:metabolism; D054706:Cyclic Nucleotide Phosphodiesterases, Type 5; D004298:Dopamine / Q000502:physiology; D004730:Endothelium, Vascular / Q000187:drug effects / Q000503:physiopathology; D007172:Erectile Dysfunction / Q000188:drug therapy; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy / Q000201:enzymology; D008297:Male; D009928:Organ Specificity; D010726:Phosphodiesterase Inhibitors / Q000627:therapeutic use*; D010879:Piperazines / Q000627:therapeutic use*; D010974:Platelet Aggregation; D011652:Pulmonary Circulation; D011687:Purines / Q000627:therapeutic use; D012701:Serotonin / Q000502:physiology; D000068677:Sildenafil Citrate; D013450:Sulfones / Q000627:therapeutic use*
D000701:Analgesics, Opioid; D010726:Phosphodiesterase Inhibitors; D010879:Piperazines; D011687:Purines; D013450:Sulfones; D012701:Serotonin; D000068677:Sildenafil Citrate; D015106:3',5'-Cyclic-GMP Phosphodiesterases; D054706:Cyclic Nucleotide Phosphodiesterases, Type 5; C517381:PDE5A protein, human; D004298:Dopamine