[Antifungal activity of the novel adduct, GX-95, of silver with nanometer-scale particles to peptidic hydrolysates from collagen].
Silver has long been known to have an antimicrobial activity against bacteria and other microorganisms, and has been used as eating utensils, as dental fillings and so on. We developed a novel adduct, GX-95, of silver with nanometer-scale particles to peptidic hydrolysates from collagen. Antifungal activity of the adduct against pathogenic yeasts and filamentous fungi was examined in terms of minimal inhibitory concentrations (MICs). GX-95 was found to possess strong and broad antifungal activities against all fungi examined in the following MICs: 0.25 to 0.31 microg/ml for Candida albicans including resistant strains to fluconazole, itraconazole and flucytosine, 0.05 to 0.2 microg/ml for Cryptococcus neoformans strains, 0.025 to 0.4 microg/ml for Aspergillus fumigatus strains, 0.4 microg/ml for Trichophyton rubrum, and 0.05 microg/ml for Cladophialophora carrionii.
Yaguchi
Takashi
T
Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, 1-801 Inohana, Chuo-ku, Chiba 260-8673, Japan.
Takizawa
Kyoko
K
Taguchi
Hideaki
H
Tanaka
Reiko
R
Kubota
Tadashi
T
Kubota
Yoshiaki
Y
Kubota
Masaaki
M
Fukushima
Kazutaka
K
D000935:Antifungal Agents / Q000494:pharmacology*; D003094:Collagen; D005658:Fungi / Q000187:drug effects*; D053758:Nanoparticles; D011492:Protein Hydrolysates; D012834:Silver / Q000494:pharmacology*
D000935:Antifungal Agents; D011492:Protein Hydrolysates; D012834:Silver; D003094:Collagen