Resolution of autoimmune polyglandular syndrome-associated keratopathy with keratolimbal stem cell transplantation: case report and historical literature review.
OBJECTIVE
To describe the presentation and treatment of a case of autoimmune polyglandular syndrome type 1 (APS1)-associated keratopathy and to review the associated literature.


METHODS
A 23-year-old man with decreased vision secondary to APS1-associated keratopathy was treated with systemic immunosuppression and keratolimbal allograft (KLAL) stem cell transplantation.


RESULTS
The patient maintains excellent vision 27 months after KLAL and systemic immunosuppression.


CONCLUSIONS
An underlying etiology of APS1-associated keratopathy is stem cell deficiency, which can be treated effectively with KLAL and systemic immunosuppression.
Shah
Manan
M
Cincinnati Eye Institute, Edgewood, KY 41017, USA.
Holland
Edward
E
Chan
Chi-Chao
CC
D000328:Adult; D003316:Corneal Diseases / Q000209:etiology* / Q000601:surgery*; D004847:Epithelial Cells / Q000637:transplantation; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016850:Limbus Corneae / Q000166:cytology*; D008297:Male; D016884:Polyendocrinopathies, Autoimmune / Q000150:complications*; D033581:Stem Cell Transplantation / Q000379:methods*; D013234:Stem Cells / Q000502:physiology; D014184:Transplantation, Homologous; D014792:Visual Acuity
D007166:Immunosuppressive Agents