Functional connectivity mapping using the ferromagnetic Potts spin model.
An unsupervised stochastic clustering method based on the ferromagnetic Potts spin model is introduced as a powerful tool to determine functionally connected regions. The method provides an intuitively simple approach to clustering and makes no assumptions of the number of clusters in the data or their underlying distribution. The performance of the method and its dependence on the intrinsic parameters (size of the neighborhood, form of the interaction term, etc.) is investigated on the simulated data and real fMRI data acquired during a conventional periodic finger tapping task. The merits of incorporating Euclidean information into the connectivity analysis are discussed. The ability of the Potts model clustering to uncover the hidden structure in the complex data is demonstrated through its application to the resting-state data to determine functional connectivity networks of the anterior and posterior cingulate cortices for the group of nine healthy male subjects.
Stanberry
Larissa
L
Department of Statistics, University of Washington, Seattle, Washington 98195-4322, USA. lstan@u.washington.edu
Murua
Alejandro
A
Cordes
Dietmar
D
D000328:Adult; D000465:Algorithms; D001921:Brain / Q000033:anatomy & histology* / Q000502:physiology; D001931:Brain Mapping / Q000379:methods*; D016000:Cluster Analysis; D003198:Computer Simulation; D005385:Fingers / Q000294:innervation / Q000502:physiology; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008280:Magnetics; D008297:Male; D015233:Models, Statistical; D008962:Models, Theoretical; D009068:Movement / Q000502:physiology; D009434:Neural Pathways / Q000033:anatomy & histology / Q000502:physiology; D013269:Stochastic Processes