title: Association study between the transferrin gene and schizophrenia in the Japanese population.
abstract: Several lines of evidence, including diffusion tensor imaging and microarray studies, indicate that abnormalities in myelination play an important role in the pathophysiology of schizophrenia. Of myelin and oligodendrocyte-related genes, a significant decrease in the mRNA levels of transferrin in schizophrenics has been reported by both microarray and quantitative polymerase chain reaction studies. We performed an association analysis of the transferrin gene in a Japanese population of 384 schizophrenic patients and 384 controls. Six single nucleotide polymorphisms were genotyped by polymerase chain reaction-restriction fragment length polymorphism and a TaqMan assay. No significant differences in genotype, allele, or haplotype frequencies of the six single nucleotide polymorphisms were observed between schizophrenic patients and controls. The present results suggest that the transferrin gene is not related to the development of schizophrenia in the Japanese population.
authors.affiliation: Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan. n-maeno@med.nagoya-u.ac.jp
authors.forename: Nobuhisa
authors.initials: N
authors.lastname: Maeno
authors.forename: Nagahide
authors.initials: N
authors.lastname: Takahashi
authors.forename: Shinichi
authors.initials: S
authors.lastname: Saito
authors.forename: Xiaofei
authors.initials: X
authors.lastname: Ji
authors.forename: Aleksic
authors.initials: A
authors.lastname: Branko
authors.forename: Ryoko
authors.initials: R
authors.lastname: Ishihara
authors.forename: Keizo
authors.initials: K
authors.lastname: Yoshida
authors.forename: Toshiya
authors.initials: T
authors.lastname: Inada
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Iidaka
authors.forename: Norio
authors.initials: N
authors.lastname: Ozaki
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012559:Schizophrenia / Q000453:epidemiology / Q000235:genetics*; D014168:Transferrin / Q000235:genetics*
chemical_list: D014168:Transferrin