[The complex adaptogenic drug tonizid attenuates myocardial contractile dysfunction and prevents irreversible cardiomyocytic damages in ischemia and reperfusion of the isolated heart].
A course administration of the complex plant adaptogenic drug tonizid was ascertained to increase murine exercise tolerance. In addition, the drug increased murine survival during hypobaric hypoxia (at an altitude of 10,500 m upon 20-min exposure). A model of total 35-min ischemia and that of 30-min reperfusion of the rat isolated heart were used by the Langendorff technique. The course administration of tonizid attenuated a reperfusion decrease in the left ventricular pressure and in the rate of contraction. However, tonizid did not prevent a reperfusion reduction in heart rate, a decrease in the rate of relaxation and an elevation of end diastolic pressure. Tonizid lowered the level of creatine kinase in the venous effluent from the isolated rat heart during reperfusion. At the same time, the plant adaptogen exerted no effect on the incidence of ventricular arrhythmias and coronary flow. It has been suggested that tonizid is an adaptogenic drug that attenuates contractile dysfunction and prevents irreversible cardiomyocytic damage during ischemia and reperfusion of the isolated heart.
Maslov
L N
LN
Platonov
A A
AA
Arbuzov
A G
AG
Burkova
V N
VN
Naryzhnaia
N V
NV
D000222:Adaptation, Physiological; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D000252:Calcium-Transporting ATPases / Q000187:drug effects / Q000378:metabolism; D002316:Cardiotonic Agents / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical / Q000379:methods; D006339:Heart Rate / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D009200:Myocardial Contraction / Q000187:drug effects*; D017202:Myocardial Ischemia / Q000188:drug therapy* / Q000473:pathology; D015428:Myocardial Reperfusion Injury / Q000517:prevention & control*; D032383:Myocytes, Cardiac / Q000187:drug effects / Q000473:pathology*; D010889:Piracetam / Q000494:pharmacology; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D002316:Cardiotonic Agents; D010936:Plant Extracts; D000252:Calcium-Transporting ATPases; D010889:Piracetam