title: Cytotoxic prenylated phenolic compounds from the twig bark of Garcinia xanthochymus.
abstract: Three new hydroxylated xanthones with prenyl or geranyl substituents, compounds 1-3, were isolated from the twig bark of Garcinia xanthochymus, along with the four known compounds 1,4,5,6-tetrahydroxy-7,8-diprenylxanthone (4), 1,3,5,6-tetrahydroxy-4,7,8-triprenylxanthone (5), garciniaxanthone E (6), and 6-prenylapigenin (7). Their structures were elucidated by extensive spectroscopic analysis, including 1D- and 2D-NMR as well as HR-MS experiments. All compounds showed moderate cytotoxicities against breast cancer (MDA-MB-435S) and lung adenocarcinoma (A549) cell lines, but lacked antifungal activity against Candida albicans.
authors.affiliation: Laboratory of Chinese Medicine, Hong Kong Jockey Club Institute of Chinese Medicine, Hong Kong, PR China.
authors.forename: Quan-Bin
authors.initials: QB
authors.lastname: Han
authors.forename: Chun-Feng
authors.initials: CF
authors.lastname: Qiao
authors.forename: Jing-Zheng
authors.initials: JZ
authors.lastname: Song
authors.forename: Nian-Yun
authors.initials: NY
authors.lastname: Yang
authors.forename: Xin-Wei
authors.initials: XW
authors.lastname: Cao
authors.forename: Yong
authors.initials: Y
authors.lastname: Peng
authors.forename: Da-Jian
authors.initials: DJ
authors.lastname: Yang
authors.forename: Shi-Lin
authors.initials: SL
authors.lastname: Chen
authors.forename: Hong-Xi
authors.initials: HX
authors.lastname: Xu
mesh_terms: D000935:Antifungal Agents / Q000302:isolation & purification / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D001562:Benzimidazoles / Q000302:isolation & purification / Q000494:pharmacology; D001943:Breast Neoplasms / Q000473:pathology; D002176:Candida albicans / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects*; D003517:Cyclopentanes / Q000302:isolation & purification / Q000494:pharmacology; D029760:Garcinia / Q000737:chemistry*; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology; D010636:Phenols / Q000302:isolation & purification / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects; D044004:Xanthones / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: C436284:2-cyclopentyl-5-(5-isoquinolylsulfonyl)-6-nitro-1H-benzo(D)imidazole; D000935:Antifungal Agents; D000970:Antineoplastic Agents; D001562:Benzimidazoles; D003517:Cyclopentanes; D010636:Phenols; D044004:Xanthones