Clinical study of uric acid urolithiasis.
Uric acid urolithiasis develops from various causes. To investigate the clinical and biochemical presentation of patients with uric acid urolithiasis, a retrospective study was designed. A total of 46 cases were enrolled between January 2004 and December 2005. The compositions of the stones were analyzed by infrared spectrophotometry. There were 39 males (84.8%) and seven females (15.2%), with a mean age of 61.5 +/- 10.6 years and mean body mass index (BMI) of 26.7 +/- 3.1 kg/m2. The stone location was kidney in 10 (21.7%), ureter in 22 (41.8%), and bladder in 14 (30.5%). Multiple stones were diagnosed in 36 patients (78.3%). Pre-existing comorbidities included diabetes mellitus in 11 patients (23.9%), hypertension in 23 (50%), gout in 13 (28.2%), and benign prostatic hyperplasia in 14 (30.4%). Mean serum creatinine and uric acid was 1.6 +/- 0.6 mg/dL and 7.6 +/- 1.8 mg/dL, respectively. There were 27 patients (58%) with creatinine > 1.4 mg/dL. The mean urinary pH was 5.42 +/- 0.46. Patients with uric acid urolithiasis were predominantly male, older, with higher BMI, multiple stone presentation, with lower urinary pH, and hyperuricemia. Exacerbation of the renal function should also be of concern because of the high proportion of patients with renal insufficiency diagnosed in this study.
Chou
Yii-Her
YH
Department of Urology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Taiwan. yihech@kmu.edu.tw
Li
Wei-Ming
WM
Li
Ching-Chia
CC
Huang
Shu-Pin
SP
Liu
Chia-Chu
CC
Wu
Wen-Jeng
WJ
Hsiao
Hsi-Lin
HL
Chang
Tu-Hao
TH
Juan
Yung-Shun
YS
Su
Chien-Yu
CY
Hsu
Hsing
H
Huang
Chun-Hsiung
CH
D000328:Adult; D000368:Aged; D015992:Body Mass Index; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012737:Sex Factors; D014527:Uric Acid / Q000378:metabolism*; D052878:Urolithiasis / Q000209:etiology*
D014527:Uric Acid