title: Grade migration in prostate cancer: an analysis using the Surveillance, Epidemiology, and End Results registry.
abstract: To utilize the Surveillance, Epidemiology, and End Results (SEER) registry to examine trends in grade assignment. Data from 411 325 patients from 1984 to 2003 were analyzed for grade migration and for cause-specific survival (CSS) as a function of grade. There has been a significant grade migration during the study period (P<0.001), principally from well-differentiated (WD) to moderately differentiated (MD) disease. Five-year CSS of MD and WD patients have converged, suggesting a decreasing role of grade as a prognostic factor. A grade migration from WD to MD assignment has occurred, suggesting that prognostic categorizations based on grade across eras may be difficult to interpret.
authors.affiliation: Department of Radiation Oncology and Urology, Emory University, Atlanta, GA, USA. jani_1969@yahoo.com
authors.forename: A B
authors.initials: AB
authors.lastname: Jani
authors.forename: V A
authors.initials: VA
authors.lastname: Master
authors.forename: P J
authors.initials: PJ
authors.lastname: Rossi
authors.forename: S L
authors.initials: SL
authors.lastname: Liauw
authors.forename: P A S
authors.initials: PA
authors.lastname: Johnstone
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002454:Cell Differentiation; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D011471:Prostatic Neoplasms / Q000453:epidemiology / Q000473:pathology*; D012042:Registries; D018426:SEER Program / Q000706:statistics & numerical data*; D015996:Survival Rate