Pulmonary lymphomatoid granulomatosis in a renal allograft recipient.
Lymphomatoid granulomatosis (LYG) is a rare multisystemic angiocentric lymphoproliferative disease, which can masquerade as necrotic tissue. There is a paucity of reports of LYG in renal transplant recipients. Herein, we describe LYG in a 56-year-old renal allograft recipient 11 years after transplantation, on azathioprine and prednisolone maintenance immunosuppression, presenting to us with fever, weight loss, and nodular and patchy opacities in both lung fields. Initial percutaneous samples showed necrotic tissue while open biopsy revealed characteristic histopathology with evidence of Epstein-Barr virus. We have reviewed the radiological and pathological findings, and discussed clinical features, differential diagnosis, and treatment of LYG.
Joseph
R
R
Department of Nephrology, Christian Medical College, Vellore, India.
Chacko
B
B
Manipadam
M T
MT
Sureka
J
J
Cherian
V K
VK
John
G T
GT
D020031:Epstein-Barr Virus Infections / Q000473:pathology / Q000821:virology; D005260:Female; D004854:Herpesvirus 4, Human / Q000302:isolation & purification; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D008175:Lung Neoplasms / Q000473:pathology / Q000821:virology; D008230:Lymphomatoid Granulomatosis / Q000473:pathology / Q000821:virology; D008875:Middle Aged; D014184:Transplantation, Homologous / Q000009:adverse effects*