Successful treatment of a disseminated Sporothrix schenckii infection and in vitro analysis for antifungal susceptibility testing.
We report a case of a diabetic patient with localized osteoarticular sporotrichosis followed by widespread dissemination of the infection, which was successfully treated with amphotericin B. In addition, we evaluated the in vitro antifungal activity of 4 agents against both the mycelial and the yeast forms of the isolated fungus.
Kohler
Lidiane Meire
LM
Universidade Federal de Minas Gerais, Instituto de Ciências Biológicas, Departamento de Microbiologia, 31270-901, Belo Horizonte, MG, Brazil.
Hamdan
Júnia Soares
JS
Ferrari
Teresa Cristina Abreu
TC
D000666:Amphotericin B / Q000494:pharmacology / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000494:pharmacology / Q000627:therapeutic use*; D048909:Diabetes Complications; D005260:Female; D006801:Humans; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000150:complications / Q000382:microbiology; D013175:Sporothrix / Q000187:drug effects*; D013174:Sporotrichosis / Q000188:drug therapy* / Q000382:microbiology; D016896:Treatment Outcome
D000935:Antifungal Agents; D000666:Amphotericin B