[Familial hypobetalipoproteinemia secondary to a mutation in the apolipoprotein B gene].
Familial hypobetalipoproteinemia (FHB) is a rare genetically heterogeneous disorder provoking abnormally low serum levels of apoprotein (apo) B, total cholesterol, and low-density lipoprotein (LDL-C). Patients carrying heterozygous mutations in the APOB (2p24) gene are usually asymptomatic, but homozygous mutations cause clinical disturbances as a result of intestinal fat malabsorption and fat-soluble vitamin deficiency. We present an asymptomatic boy, aged 8 years and 7 months, with low serum levels of apo-B, total cholesterol, triglyceride, LDL-C and very low-density lipoprotein (VLDL-C), as well as vitamin E deficiency. Three asymptomatic relatives also exhibited low apo-B, total cholesterol and LDL-C levels. The APOB (2p24) gene was fully sequenced, demonstrating a heterozygous mutation in exon 26 (G --> T) in all four members of this family. Familial genetic studies in FHB could be useful in the early detection and treatment of homozygous carriers.
Blanco-Rodríguez
M
M
Servicio de Endocrinología, Departamento de Pediatría, Hospital Infantil Universitario Niño Jesús, Universidad Autónoma de Madrid, Spain.
Muñoz-Calvo
M T
MT
Martos-Moreno
G A
GA
Abad-Pérez
E
E
Argente-Oliver
J
J
D001055:Apolipoproteins B / Q000235:genetics*; D002648:Child; D006801:Humans; D052476:Hypobetalipoproteinemia, Familial, Apolipoprotein B / Q000235:genetics*; D008297:Male; D009154:Mutation
D001055:Apolipoproteins B