Atrial natriuretic peptide (ANP) gene promoter variant and increased susceptibility to early development of hypertension in humans.
Previous evidence supports a role of atrial natriuretic peptide (ANP) as a candidate gene for hypertension. We characterized an ANP gene promoter variant, which has been associated with lower peptide levels, in a sample of young male subjects from Southern Italy (n=395, mean age=35.2+/-2 years) followed up for 28 years. In this cohort, the ANP gene variant was associated with early blood pressure increase and predisposition to develop hypertension.
Rubattu
S
S
Evangelista
A
A
Barbato
D
D
Barba
G
G
Stanzione
R
R
Iacone
R
R
Volpe
M
M
Strazzullo
P
P
D000328:Adult; D009320:Atrial Natriuretic Factor / Q000235:genetics*; D001794:Blood Pressure / Q000235:genetics*; D016009:Chi-Square Distribution; D003430:Cross-Sectional Studies; D005500:Follow-Up Studies; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D007558:Italy; D008137:Longitudinal Studies; D008297:Male; D012150:Polymorphism, Restriction Fragment Length; D011401:Promoter Regions, Genetic / Q000235:genetics
D009320:Atrial Natriuretic Factor