title: Bowel colonization with vancomycin-resistant enterococci after antimicrobial therapy for intra-abdominal infections: observations from 2 randomized comparative clinical trials of ertapenem therapy.
abstract: The impact of different antimicrobial regimens for intra-abdominal infections on the frequency of bowel colonization with vancomycin-resistant enterococci (VRE) was examined in 2 randomized open-label trials of intra-abdominal infection comparing piperacillin-tazobactam or ceftriaxone/metronidazole with ertapenem. In these short-term studies, overall rates of bowel colonization with VRE were generally comparable after treatment with piperacillin-tazobactam, ceftriaxone/metronidazole, or ertapenem.
authors.affiliation: Merck & Co., Inc., Whitehouse Station, NJ, USA. mark_dinubile@merck.com
authors.forename: Mark J
authors.initials: MJ
authors.lastname: DiNubile
authors.forename: Ian R
authors.initials: IR
authors.lastname: Friedland
authors.forename: Christina Y
authors.initials: CY
authors.lastname: Chan
authors.forename: Mary R
authors.initials: MR
authors.lastname: Motyl
authors.forename: Hilde
authors.initials: H
authors.lastname: Giezek
authors.forename: Kathleen
authors.initials: K
authors.lastname: McCarroll
authors.forename: Malathi
authors.initials: M
authors.lastname: Shivaprakash
authors.forename: John P
authors.initials: JP
authors.lastname: Quinn
authors.forename: Robert A
authors.initials: RA
authors.lastname: Weinstein
authors.forename: Joseph W
authors.initials: JW
authors.lastname: Chow
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D016983:Enterococcus / Q000187:drug effects* / Q000254:growth & development* / Q000302:isolation & purification; D000077727:Ertapenem; D005260:Female; D016908:Gram-Positive Bacterial Infections / Q000382:microbiology*; D006801:Humans; D007422:Intestines / Q000382:microbiology*; D008297:Male; D008875:Middle Aged; D020713:Vancomycin Resistance; D047090:beta-Lactams / Q000627:therapeutic use*
chemical_list: D000900:Anti-Bacterial Agents; D047090:beta-Lactams; D000077727:Ertapenem