A long and winding road: the Plasmodium sporozoite's journey in the mammalian host.
The Plasmodium sporozoite, the infectious stage of the malaria parasite, makes a remarkable journey in its mammalian host. Here we review our current knowledge of the molecular and cellular basis of this journey, which begins in the skin and ends in the hepatocyte.
Sinnis
Photini
P
Department of Medical Parasitology, New York University School of Medicine, 341 East 25th Street, New York, NY 10010, United States. photini.sinnis@med.nyu.edu
Coppi
Alida
A
D000818:Animals; D022781:Hepatocytes / Q000469:parasitology; D006790:Host-Parasite Interactions; D006801:Humans; D010961:Plasmodium / Q000145:classification / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D015800:Protozoan Proteins / Q000235:genetics / Q000378:metabolism; D012867:Skin / Q000469:parasitology; D034101:Sporozoites / Q000378:metabolism / Q000502:physiology*
D015800:Protozoan Proteins