Deprotonation and regioselective addition of 2H-pyrazolo[3,4-c]quinolines to electrophiles.
The deprotonation and regioselective reaction of 2H-pyrazolo[3,4-c]quinolines with a variety of electrophiles is described. Electrophiles include benzaldehyde, DMF, carbon dioxide, and iodine. This method provides a direct route to a class of pharmacologically interesting compounds.
Danielson
Michael E
ME
3M Pharmaceuticals, 3M Center, Building 270-4S-02, St. Paul, Minnesota 55144-1000, USA. mdanielson@biotherapharma.com
Hays
David S
DS
Kshirsagar
Tushar A
TA
Haraldson
Chad A
CA
Lundquist
Gregory D
GD
Wurst
Joshua R
JR
Lindstrom
Kyle J
KJ
Mackey
Sonja S
SS
Willie
Daniel J
DJ
Heppner
Philip D
PD
Leir
Charles M
CM
Benson
Karl E
KE
D001547:Benzaldehydes / Q000737:chemistry; D002245:Carbon Dioxide / Q000737:chemistry; D004126:Dimethylformamide / Q000737:chemistry; D007455:Iodine / Q000737:chemistry; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry
D001547:Benzaldehydes; D011720:Pyrazoles; D011804:Quinolines; D002245:Carbon Dioxide; D004126:Dimethylformamide; D007455:Iodine; C032175:benzaldehyde