title: Patent foramen ovale and migraine.
abstract: Results from several observational studies indicate an association between migraine and patent foramen ovale (PFO). Several biological mechanisms have been proposed to explain this link, including shared genetic inheritance. However, there is currently insufficient evidence to support a causal link between PFO and migraine. Although the results of uncontrolled observational studies suggest the PFO closure may have a beneficial effect on migraine frequency, a large randomized trial failed to support such a conclusion. Until there is more evidence from ongoing large controlled trials, PFO closure should not be performed in clinical practice for the prophylaxis of migraine.
authors.affiliation: Department of Neurology, University Duisburg-Essen, Hufelandstrasse 55, 45122 Essen, Germany. hans.diener@uni-duisburg-essen.de
authors.forename: Hans-Christoph
authors.initials: HC
authors.lastname: Diener
authors.forename: Tobias
authors.initials: T
authors.lastname: Kurth
authors.forename: David
authors.initials: D
authors.lastname: Dodick
mesh_terms: D006344:Heart Septal Defects, Atrial / Q000150:complications* / Q000453:epidemiology / Q000601:surgery; D006801:Humans; D008881:Migraine Disorders / Q000453:epidemiology / Q000209:etiology* / Q000517:prevention & control