The risk of premalignant and malignant pathology in endometrial polyps: should every polyp be resected?
OBJECTIVE
There is no wide consensus in the literature on the clinical significance and management of symptomatic and asymptomatic polyps. Aims of the study are to evaluate frequency of premalignant and malignant histo-pathologic features in endometrial polyps resected hysteroscopically and identify clinical parameters able to predict final histopathologic diagnosis.


METHODS
Clinical data and pathologic report of 90 consecutive operative hysteroscopies performed on women with endometrial polyps were collected. Frequency of premalignant and malignant histopathologic features on the polyps were calculated and relation to clinical risk factors analyzed.


RESULTS
The frequency of premalignant and malignant histopathologic features in polyps was 6.7% and 2.2% respectively. Owing to the small sample size no statistical analysis to detect clinical risk factor for premalignant or malignant histopathologic features could be performed.


CONCLUSIONS
Frequency of premalignant and malignant histopathologic features in symptomatic and asymptomatic patients is not negligible. Reported clinical risk factors for malignant degeneration of endometrial polypoid lesions are the same as those reported for endometrial cancer and are very common in patients with endometrial polyps. Every endometrial polyp should be resected.
Papadia
A
A
Department of Obstetrics and Gynecology, San Martino Hospital, University of Genova, Largo R. Benzi, 16129 Genoa, Italy.
Gerbaldo
D
D
Fulcheri
E
E
Ragni
N
N
Menoni
S
S
Zanardi
S
S
Brusacà
B
B
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016889:Endometrial Neoplasms / Q000453:epidemiology* / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D008875:Middle Aged; D011127:Polyps / Q000453:epidemiology* / Q000473:pathology / Q000601:surgery*; D011230:Precancerous Conditions; D011446:Prospective Studies; D012307:Risk Factors