Clinical importance of precursor lesions in the pancreas.
Three distinct noninvasive precursor lesions to invasive ductal adenocarcinoma of the pancreas have been described. These include the mucinous cystic neoplasm, intraductal papillary mucinous neoplasm, and pancreatic intraepithelial neoplasia. The early detection and treatment of these lesions can interrupt the progression of a curable noninvasive precursor to an almost uniformly deadly invasive cancer.
Hruban
Ralph H
RH
Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Weinberg Room 2242, 401 North Broadway, Baltimore, MD, USA.
Takaori
Kyoichi
K
Canto
Marcia
M
Fishman
Elliot K
EK
Campbell
Kurtis
K
Brune
Kieran
K
Kern
Scott E
SE
Goggins
Michael
M
D021441:Carcinoma, Pancreatic Ductal / Q000473:pathology; D018450:Disease Progression; D006801:Humans; D010179:Pancreas / Q000473:pathology*; D010190:Pancreatic Neoplasms / Q000473:pathology*; D011230:Precancerous Conditions / Q000473:pathology*