title: [The diabetic child and the specifics of insulin therapy].
abstract: The incidence of diabetes type I has increased considerably in young children with an annual increase in Switzerland of 23,8% over the last ten years. The development of rapid acting and long acting analogues allowed a significant progress in treatment. Multiple daily insulin injections together with carbohydrate counting as well as continuous subcutaneous insulin infusion (CSII) improved the quality of life and led to an increased daily flexibility. The incidence of severe hypoglycaemic events has decreased at the same time metabolic control improved. The development of interstitial glucose measurement (online) coupled to the insulin pump represents a step further towards the artificial pancreas. The new therapeutic strategies of immunomodulation will hopefully lead to secondary and tertiary prevention of diabetes.
authors.affiliation: Unité d'endocrinologie et diabétologie pédiatriques, Département de pédiatrie, HUG, Genève. Mirjam.Dirlewanger@hcuge.ch
authors.forename: M
authors.initials: M
authors.lastname: Dirlewanger
authors.forename: L
authors.initials: L
authors.lastname: Perrenoud
authors.forename: M
authors.initials: M
authors.lastname: Castellsague-Perolini
authors.forename: V M
authors.initials: VM
authors.lastname: Schwitzgebel
mesh_terms: D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D004334:Drug Administration Schedule; D005951:Glucose Tolerance Test; D006442:Glycated Hemoglobin / Q000378:metabolism; D006456:Hemoglobinuria / Q000209:etiology; D006801:Humans; D007003:Hypoglycemia / Q000139:chemically induced / Q000517:prevention & control; D007004:Hypoglycemic Agents / Q000145:classification / Q000627:therapeutic use*; D015918:Infusion Pumps, Implantable; D007279:Injections, Subcutaneous; D007328:Insulin / Q000008:administration & dosage / Q000627:therapeutic use*; D007332:Insulin Infusion Systems; D018670:Monitoring, Ambulatory; D011788:Quality of Life; D016896:Treatment Outcome
chemical_list: D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents; D007328:Insulin