title: A transgenic rat expressing human APP with the Swedish Alzheimer's disease mutation.
abstract: In recent years, transgenic mice have become valuable tools for studying mechanisms of Alzheimer's disease (AD). With the aim of developing an animal model better for memory and neurobehavioural testing, we have generated a transgenic rat model of AD. These animals express human amyloid precursor protein (APP) containing the Swedish AD mutation. The highest level of expression in the brain is found in the cortex, hippocampus, and cerebellum. Starting after the age of 15 months, the rats show increased tau phosphorylation and extracellular Abeta staining. The Abeta is found predominantly in cerebrovascular blood vessels with very rare diffuse plaques. We believe that crossing these animals with mutant PS1 transgenic rats will result in accelerated plaque formation similar to that seen in transgenic mice.
authors.affiliation: Karolinska Institutet, Department of Neurobiology, Caring Sciences and Society, Novum, 141 86 Stockholm, Sweden.
authors.forename: Ronnie
authors.initials: R
authors.lastname: Folkesson
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Malkiewicz
authors.forename: Ewa
authors.initials: E
authors.lastname: Kloskowska
authors.forename: Tatjana
authors.initials: T
authors.lastname: Nilsson
authors.forename: Elena
authors.initials: E
authors.lastname: Popova
authors.forename: Nenad
authors.initials: N
authors.lastname: Bogdanovic
authors.forename: Ursula
authors.initials: U
authors.lastname: Ganten
authors.forename: Detlev
authors.initials: D
authors.lastname: Ganten
authors.forename: Michael
authors.initials: M
authors.lastname: Bader
authors.forename: Bengt
authors.initials: B
authors.lastname: Winblad
authors.forename: Eirikur
authors.initials: E
authors.lastname: Benedikz
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics* / Q000378:metabolism*; D000682:Amyloid / Q000096:biosynthesis* / Q000737:chemistry / Q000378:metabolism; D000818:Animals; D030801:Animals, Genetically Modified; D001921:Brain / Q000378:metabolism; D002531:Cerebellum / Q000378:metabolism; D002540:Cerebral Cortex / Q000378:metabolism; D005821:Genetic Techniques; D006624:Hippocampus / Q000378:metabolism; D006801:Humans; D009154:Mutation; D053764:Presenilin-1 / Q000235:genetics*; D051381:Rats; D013548:Sweden; D016875:tau Proteins / Q000378:metabolism
chemical_list: D000682:Amyloid; D053764:Presenilin-1; D016875:tau Proteins