Patterns of nonclassical MHC antigen presentation.
The identification of pattern-recognition receptors that selectively respond to evolutionarily conserved chemical (often pathogen-derived) moieties has provided key insight into how innate immune cells facilitate rapid and relatively specific antimicrobial immune activity. In contrast, relatively slower adaptive immune responses rely on T cell clonal expansion that develops in response to variable peptides bound to the groove of classical major histocompatibility complex (MHC) proteins. For certain nonclassical 'MHC-like' class Ib proteins, such as H2-M3 and CD1d, their respective binding grooves seem to have been adapted to present to T cells unique molecular patterns analogous to those involved in innate signaling. Here we propose that another MHC class Ib protein, MR1, which is required for the gut flora-dependent development of mucosa-associated invariant T cells, presents either a microbe-produced or a microbe-induced pattern.
Hansen
Ted H
TH
Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, Missouri 63110, USA. hansen@wustl.edu
Huang
Shouxiong
S
Arnold
Phoebe L
PL
Fremont
Daved H
DH
D000220:Adaptation, Biological / Q000276:immunology; D000818:Animals; D017951:Antigen Presentation / Q000276:immunology*; D015395:Histocompatibility Antigens Class I / Q000145:classification / Q000235:genetics / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology; D008213:Lymphocyte Activation / Q000276:immunology; D018448:Models, Immunological; D013601:T-Lymphocytes / Q000276:immunology
D015395:Histocompatibility Antigens Class I