title: Surgical outcome of superficial and deep Castleman disease.
abstract: BACKGROUND
  Castleman disease is a rare lymphoproliferative disease of low malignant potential occurring in two forms, unicentric and multicentric. Surgery, chemotherapy, immunotherapy and radiation therapy have all been used to manage the disease. In this study, we evaluate whether the site of the lesions, that is, superficial or deep, influences the surgical outcome.
  
  
  METHODS
  We retrospectively reviewed the records of 20 patients operated on for Castleman disease from 1994 to 2003, of whom 11 patients had superficial disease and 9 had deep lesions. The end-points of this study were survival and recurrence.
  
  
  RESULTS
  Of the 20 patients, 19 had unicentric (cervical in 8, mediastinal in 5, retroperitoneal in 2, axillary in 2, hepatic in 1, and mesenteric in 1) and 1 had multicentric Castleman disease. Among 19 patients who had complete resection (18 with unicentric and 1 with multicentric disease), there has been no evidence of recurrence.
  
  
  CONCLUSIONS
  Whether Castleman disease is superficial or deep has no effect on surgical outcome as long as resection is complete.
authors.affiliation: Department of Surgery, Mackay Memorial Hospital, Taipei City, Taiwan.
authors.forename: Chih-Hao
authors.initials: CH
authors.lastname: Chen
authors.forename: Hung-Chang
authors.initials: HC
authors.lastname: Liu
authors.forename: Kwang-Yi
authors.initials: KY
authors.lastname: Tung
authors.forename: Jie-Jen
authors.initials: JJ
authors.lastname: Lee
authors.forename: Chien-Liang
authors.initials: CL
authors.lastname: Liu
authors.forename: Tsang-Pai
authors.initials: TP
authors.lastname: Liu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005871:Castleman Disease / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D002648:Child; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome