Anthraquinones, Cdc25B phosphatase inhibitors, isolated from the roots of Polygonum multiflorum Thunb.
Three anthraquinones, Cdc25B phosphatase inhibitors, were isolated from the methanolic extract of the roots of Polygonum multiflorum Thunb. (Polygonaceae). Anthraquinones, physcion (1), emodin (2), and questin (3), inhibited the enzymatic activity of Cdc25B phosphatase with IC(50) values of 62.5, 30, and 34 microg mL(-1), respectively. Emodin (2) and questin (3) strongly inhibited the growth of human colon cancer cells, SW620 with GI(50) values of 6.1 and 0.9 microg mL(-1), respectively. Commercially available anthraquinones, chrysophanol (4), and rhein (5) also inhibited Cdc25B phosphatase with IC(50) values of 10.7 and 22.1 microg mL(-1), respectively.
Choi
Sung-Gyu
SG
Korea Research Institute of Bioscience and Biotechnology, University of Science and Technology in Korea, Yoosung-Gu, Daejeon, Republic of Korea.
Kim
Jiin
J
Sung
Nack-Do
ND
Son
Kwang-Hee
KH
Cheon
Hyae-Gyeong
HG
Kim
Kwang-Rok
KR
Kwon
Byoung-Mog
BM
D018797:Cell Cycle Proteins / Q000037:antagonists & inhibitors*; D045744:Cell Line, Tumor; D003110:Colonic Neoplasms; D004642:Emodin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry*; D028502:Polygonum / Q000737:chemistry*; D020687:cdc25 Phosphatases / Q000037:antagonists & inhibitors*
D018797:Cell Cycle Proteins; D004791:Enzyme Inhibitors; C048944:questin; C517008:CDC25B protein, human; D020687:cdc25 Phosphatases; C008905:physcione; D004642:Emodin