title: [Optimization of formulation matrix proportion and preparation technology of realgar floating tablets for gastric retention by uniform design and correlation analysis].
abstract: OBJECTIVE
  To optimize the different components proportions of the Realgar floating tablets for gastric retention by uniform design and correlation analysis.
  
  
  METHODS
  With the different dosage of hydroxypropyl methyl cellulose (HPMC) as the tablets frame matrix, uniform design and correlation analysis were used to optimize the best component proportions of formula, and to measure the dissolution of the tablets in vitro.
  
  
  RESULTS
  Dissolution of the tablets in vitro was conformed to the expectation of experiment. The drug-release mechanism was by diffusion and corrosion at the same time.
  
  
  CONCLUSIONS
  The Realgar floating tablets for gastric retention achieved the goal of design, which demand sustained release and safety.
authors.affiliation: Guiyang College of Traditional Chinese Medicine, Guiyang 550002 China.
authors.forename: Chang-Fu
authors.initials: CF
authors.lastname: Yang
authors.forename: Ya-Ping
authors.initials: YP
authors.lastname: Lin
authors.forename: Yong-Ping
authors.initials: YP
authors.lastname: Zhong
authors.forename: Feng-Yun
authors.initials: FY
authors.lastname: Qi
authors.forename: Xiao-Lan
authors.initials: XL
authors.lastname: Chen
mesh_terms: D000284:Administration, Oral; D001152:Arsenicals / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics; D003692:Delayed-Action Preparations; D005753:Gastric Mucosa / Q000378:metabolism*; D065347:Hypromellose Derivatives; D008419:Materia Medica / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics; D008747:Methylcellulose / Q000031:analogs & derivatives / Q000737:chemistry; D011205:Povidone / Q000737:chemistry; D012995:Solubility; D013440:Sulfides / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics; D013607:Tablets; D013678:Technology, Pharmaceutical / Q000379:methods*
chemical_list: D001152:Arsenicals; D003692:Delayed-Action Preparations; D008419:Materia Medica; D013440:Sulfides; D013607:Tablets; D065347:Hypromellose Derivatives; C058317:arsenic disulfide; D008747:Methylcellulose; D011205:Povidone