CRP and the disposal of dying cells: consequences for systemic lupus erythematosus and rheumatoid arthritis.
C reactive protein (CRP) levels directly correlate with the disease activity of many inflammatory diseases, e.g. sepsis, infection, and various autoimmunopathies such as rheumatoid arthritis (RA). In contrast, insufficient CRP levels are implicated in the development of systemic lupus erythematosus (SLE). This article reports on the level-depended effects of CRP in various diseases. In detail we show that increased and decreased levels of CRP, as demonstrated in patients with RA and SLE, respectively can contribute to disease progression.
Vogt
Birgit
B
Department of Biotechnology, University of Applied Science, Berlin, Germany.
Führnrohr
Barbara
B
Müller
Rüdiger
R
Sheriff
Ahmed
A
D001172:Arthritis, Rheumatoid / Q000097:blood / Q000276:immunology*; D002097:C-Reactive Protein / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000276:immunology*; D018805:Sepsis
D002097:C-Reactive Protein