[Effect of Liuwei Dihuang soft capsule and Ginkgo leaf tablet on serum regulated upon activation, normal T cell expressed and secreted in patients with diabetes mellitus type 2].
OBJECTIVE
To investigate the effect of Liuwei Dihuang Soft Capsule(LDSC) and Ginkgo Leaf Tablet (GLT) on serum regulated upon activation, normal T cell expressed and secreted (RANTES) in the patients with diabetes mellitus type 2 (DM2).


METHODS
Forty patients with early stage DM2 were randomly assigned to two groups, 20 in each group. Based on the conventional treatment with hypoglycemic agents, patients in the treated group were treated with LDSC plus GLT additionally, and those in the placebo group with placebo for 6 months, respectively. The levels of serum RANTES, blood glucose, blood lipids and glycosylated hemoglobin, as well as micro-content of albumin in urine were measured before and after treatment.


RESULTS
In the treated group, the serum level of RANTES decreased significantly after treatment, and it was significantly lower as compared with that in the control group (P < 0.05).


CONCLUSIONS
LDSC and GLT can decrease serum RANTES level in patients with DM2. They play a preventive and therapeutic role on diabetic complications by their anti-inflammatory effect.
Wang
Xiang-xiang
XX
Department of Endocrinology, Zhongda Hospital, Southeast University, Nanjing.
Sun
Zi-lin
ZL
Yu
Jiang-yi
JY
D000368:Aged; D002214:Capsules; D018946:Chemokine CCL5 / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D020441:Ginkgo biloba / Q000737:chemistry*; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D018515:Plant Leaves / Q000737:chemistry*; D013607:Tablets; D016896:Treatment Outcome
D002214:Capsules; D018946:Chemokine CCL5; D004365:Drugs, Chinese Herbal; D007004:Hypoglycemic Agents; D013607:Tablets; C476907:liu-wei-di-huang wan