Comparison of early outcome and histologic findings of enteric drainage with bladder drainage in pancreas transplantation of dogs.
BACKGROUND
The clinical and pathological findings of enteric-drained (ED) versus bladder-drained (BD) pancreas transplantation are still controversial. In this study, we compared early outcome and histological findings of these 2 methods.


METHODS
In an experimental animal model, after diabetization, 16 dogs were randomly divided into 2 groups. In the first group, the pancreas was transplanted with enteric drainage, and in the second group, with bladder drainage. We evaluated early clinical and pathological outcomes.


RESULTS
The mean survival time was 11.25 +/- 5.0 (range, 5-20) days for group 1 and 13.6 +/- 7.2 (range, 3-23) days for group 2 (P>.05). Fasting blood sugar values (FBS) before transplantation were 279 +/- 26.8 mg/dL versus 278 +/- 41.6 mg/dL, respectively (P>.05). Two weeks postoperative serum FBS had decreased to 84.9 +/- 2.9 versus 84.2 +/- 0.98, respectively (P>.05). Serum amylase in the BD and ED groups were 378.5 +/- 328 versus 422.6 +/- 54.7 mg/dL, respectively (P>.05). Early leakage was not observed in dogs with BD, whereas it was 37.5% among dogs with ED (P<.05). Clinical and pathological evidences of pancreatic necrosis occurred in 37.5% of dogs with BD versus 62.5% of dogs with ED (P>.05).


CONCLUSIONS
Although the early outcomes of these drainage methods (ED vs BD) were statistically similar more dogs with ED experienced early complications than with BD.
Salahi
H
H
Shiraz Organ Transplantation Center, Namazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran. transpln@sums.ac.ir
Nikeghbalian
S
S
Shamsaee
A R
AR
Kheradmand
E
E
Sabet
B
B
Jalaeian
H
H
Geramizadeh
B
B
Tanideh
N
N
Malek-Hosseini
S A
SA
D000818:Animals; D004285:Dogs; D004322:Drainage / Q000379:methods; D023421:Models, Animal; D016035:Pancreas Transplantation / Q000379:methods* / Q000401:mortality / Q000473:pathology / Q000502:physiology*; D016019:Survival Analysis; D016896:Treatment Outcome; D001743:Urinary Bladder / Q000601:surgery