title: Highly enantioselective synthesis of gamma-hydroxy-alpha,beta-acetylenic esters catalyzed by a beta-sulfonamide alcohol.
abstract: This work concerns the asymmetric addition of methyl propiolate to aldehydes with 1,2-dimethoxyethane (DME) as additive and beta-sulfonamide alcohol titanium complex as a catalyst. The reactions proceeded under mild conditions and gave the highly functionalized chiral propargylic alcohols with high ee values and good yields. Differences between three types of ligands have also been discussed.
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Institute of Biochemistry and Molecular Biology, Lanzhou University, Lanzhou 730000, China.
authors.forename: Li
authors.initials: L
authors.lastname: Lin
authors.forename: Xianxing
authors.initials: X
authors.lastname: Jiang
authors.forename: Weixia
authors.initials: W
authors.lastname: Liu
authors.forename: Li
authors.initials: L
authors.lastname: Qiu
authors.forename: Zhaoqing
authors.initials: Z
authors.lastname: Xu
authors.forename: Jiangke
authors.initials: J
authors.lastname: Xu
authors.forename: Albert S C
authors.initials: AS
authors.lastname: Chan
authors.forename: Rui
authors.initials: R
authors.lastname: Wang
mesh_terms: D000438:Alcohols / Q000737:chemistry*; D000480:Alkynes / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D004952:Esters / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D013237:Stereoisomerism; D013449:Sulfonamides / Q000737:chemistry*; D014025:Titanium / Q000737:chemistry*
chemical_list: D000438:Alcohols; D000480:Alkynes; D004952:Esters; D009942:Organometallic Compounds; D013449:Sulfonamides; D014025:Titanium