title: Lower extremity motor function and disability in mild cognitive impairment.
abstract: Recent findings suggest that lower extremity motor dysfunction may be a feature of mild cognitive impairment (MCI), but little is known about the nature and significance of lower extremity motor dysfunction in MCI. The aim of this study was to examine the extent to which MCI is associated with impaired gait, balance, and strength and to examine the relation of lower extremity function to disability among persons with MCI in the Rush Memory and Aging Project, a clinical-pathologic study of common chronic conditions of old age. In a series of analyses adjusted for age, sex, and education, individuals with MCI exhibited more impaired gait and balance than individuals without cognitive impairment. Because vascular factors can contribute to lower extremity motor dysfunction, the authors repeated the initial analyses including terms for vascular risk factors and vascular disease, and the associations between MCI and lower extremity motor dysfunction persisted. Moreover, among those with MCI, impairments in gait and balance were associated with an increased likelihood of disability. These findings suggest that lower extremity motor dysfunction is common and contributes to disability in MCI, but lower extremity motor dysfunction in MCI does not appear to be explained by the vascular factors examined in this study.
authors.affiliation: Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois 60612, USA. Patricia_Boyle@rush.edu
authors.forename: P A
authors.initials: PA
authors.lastname: Boyle
authors.forename: R S
authors.initials: RS
authors.lastname: Wilson
authors.forename: A S
authors.initials: AS
authors.lastname: Buchman
authors.forename: N T
authors.initials: NT
authors.lastname: Aggarwal
authors.forename: Y
authors.initials: Y
authors.lastname: Tang
authors.forename: Z
authors.initials: Z
authors.lastname: Arvanitakis
authors.forename: J
authors.initials: J
authors.lastname: Kelly
authors.forename: D A
authors.initials: DA
authors.lastname: Bennett
mesh_terms: D000203:Activities of Daily Living / Q000145:classification; D000368:Aged; D000369:Aged, 80 and over; D002318:Cardiovascular Diseases / Q000175:diagnosis / Q000523:psychology; D003072:Cognition Disorders / Q000175:diagnosis* / Q000523:psychology; D015140:Dementia, Vascular / Q000175:diagnosis* / Q000523:psychology; D004185:Disability Evaluation; D005260:Female; D005684:Gait; D006801:Humans; D007537:Isometric Contraction; D035002:Lower Extremity; D008297:Male; D008609:Mental Status Schedule; D008875:Middle Aged; D053580:Muscle Strength; D009460:Neurologic Examination; D009483:Neuropsychological Tests; D010523:Peripheral Nervous System Diseases / Q000175:diagnosis / Q000523:psychology; D004856:Postural Balance; D013223:Statistics as Topic