[Exposure of normal Tenon's capsule fibroblasts from pterygium to 5-fluorouracil and mitomycin C].
OBJECTIVE
To evaluate the fibroblast proliferation activity of normal Tenon's capsule from primary and recurrent patients with pterygium.


METHODS
A randomized prospective study was performed with 41 normal Tenon's capsule fragments from 21 primary and 20 recurrent patients with pterygium. The sample was collected from the inferior cul-de-sac. Proliferation rate from fibroblasts were evaluated after mitomycin C and 5-fluorouracil exposition. Data were submitted to statistical analysis.


RESULTS
Of the 41 cultivated normal Tenon's capsules, only 1 from primary and 2 from recurrent pterygium patients proliferated. After antimitotic exposition, the proliferation rate was similar with both drugs.


CONCLUSIONS
Mitomycin and 5-fluorouracil promote similar inhibition regarding proliferation of normal Tenon's fibroblast cultures.
Viveiros
Magda Massae Hata
MM
Departamento de Oftalmologia, Otorrinolaringologia e Cirurgia de Cabeça e Pescoço, Faculdade de Medicina, Universidade Estadual Paulista Júlio Mesquita Filho, Botucatu, SP, Brazil.
Schellini
Silvana Artioli
SA
Candeias
João
J
Padovani
Carlos Roberto
CR
D000964:Antimetabolites, Antineoplastic / Q000494:pharmacology*; D002452:Cell Count; D018929:Cell Culture Techniques; D049109:Cell Proliferation / Q000187:drug effects*; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects*; D005472:Fluorouracil / Q000494:pharmacology*; D006801:Humans; D016685:Mitomycin / Q000494:pharmacology*; D011446:Prospective Studies; D011625:Pterygium / Q000473:pathology* / Q000601:surgery; D012008:Recurrence
D000964:Antimetabolites, Antineoplastic; D016685:Mitomycin; D005472:Fluorouracil