title: Cidofovir and foscarnet for treatment of human herpesvirus 6 encephalitis in a neutropenic stem cell transplant recipient.
abstract: We report a stem cell transplant recipient who developed human herpesvirus 6 encephalitis. Human herpesvirus 6 load indicated massive intrathecal viral replication. Administration of cidofovir followed by foscarnet was associated with total clearance of human herpesvirus 6 infection. Cidofovir and foscarnet combination therapy may be beneficial for reducing mortality of (neutropenic) stem cell transplant recipients with human herpesvirus 6 encephalitis.
authors.affiliation: Institut für Medizinische Mikrobiologie und Hygiene, Universitätsklinikum Carl Gustav Carus, Dresden, Germany.
authors.forename: Christoph
authors.initials: C
authors.lastname: Pöhlmann
authors.forename: Johannes
authors.initials: J
authors.lastname: Schetelig
authors.forename: Ulrike
authors.initials: U
authors.lastname: Reuner
authors.forename: Martin
authors.initials: M
authors.lastname: Bornhäuser
authors.forename: Thomas
authors.initials: T
authors.lastname: Illmer
authors.forename: Alexander
authors.initials: A
authors.lastname: Kiani
authors.forename: Gerhard
authors.initials: G
authors.lastname: Ehninger
authors.forename: Enno
authors.initials: E
authors.lastname: Jacobs
authors.forename: Jacques
authors.initials: J
authors.lastname: Rohayem
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use*; D000077404:Cidofovir; D003596:Cytosine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D018792:Encephalitis, Viral / Q000188:drug therapy*; D017245:Foscarnet / Q000627:therapeutic use*; D006086:Graft vs Host Disease; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects; D015654:Herpesvirus 6, Human / Q000187:drug effects* / Q000472:pathogenicity; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000628:therapy; D008297:Male; D008875:Middle Aged; D063065:Organophosphonates / Q000627:therapeutic use*; D019349:Roseolovirus Infections / Q000188:drug therapy* / Q000209:etiology; D019562:Viral Load
chemical_list: D000998:Antiviral Agents; D063065:Organophosphonates; D017245:Foscarnet; D003596:Cytosine; D000077404:Cidofovir