title: Overexpression of RhoE has a prognostic value in non-small cell lung cancer.
abstract: BACKGROUND
  Increasing evidence has suggested that RhoE plays an important role in carcinogenesis and progression. However, the correlation between RhoE expression and clinical outcome in lung cancer has not been investigated.
  
  
  METHODS
  RhoE expression was detected by immunohistochemistry on tissue microarray containing samples from 115 patients with non-small cell lung cancer with a median follow-up of 54 months.
  
  
  RESULTS
  RhoE was overexpressed in the cytoplasm of lung cancer cells compared with undetectable expression of RhoE in the adjacent nontumoral cells. Patients with RhoE-negative tumors had substantially longer cancer-related survival than did patients with RhoE-positive tumors. Multivariate analysis showed that RhoE overexpression was an independent marker for cancer-related survival in the entire population after adjusting for other prognostic factors.
  
  
  CONCLUSIONS
  RhoE expression may serve as an unfavorable prognostic factor in patients with non-small cell lung cancer.
authors.affiliation: Department of Thoracic Surgery, Peking Union Medical College, Chinese Academy of Medical Sciences, 100021, Beijing, China.
authors.forename: Cuiyan
authors.initials: C
authors.lastname: Zhang
authors.forename: Fang
authors.initials: F
authors.lastname: Zhou
authors.forename: Ning
authors.initials: N
authors.lastname: Li
authors.forename: Susheng
authors.initials: S
authors.lastname: Shi
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Feng
authors.forename: Zhaoli
authors.initials: Z
authors.lastname: Chen
authors.forename: Jie
authors.initials: J
authors.lastname: Hang
authors.forename: Bin
authors.initials: B
authors.lastname: Qiu
authors.forename: Baozhong
authors.initials: B
authors.lastname: Li
authors.forename: Sheng
authors.initials: S
authors.lastname: Chang
authors.forename: Junting
authors.initials: J
authors.lastname: Wan
authors.forename: Kang
authors.initials: K
authors.lastname: Shao
authors.forename: Xuezhong
authors.initials: X
authors.lastname: Xing
authors.forename: Xiaogang
authors.initials: X
authors.lastname: Tan
authors.forename: Zhen
authors.initials: Z
authors.lastname: Wang
authors.forename: Meihua
authors.initials: M
authors.lastname: Xiong
authors.forename: Jie
authors.initials: J
authors.lastname: He
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism; D015153:Blotting, Western; D002289:Carcinoma, Non-Small-Cell Lung / Q000378:metabolism*; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008175:Lung Neoplasms / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016016:Proportional Hazards Models; D016019:Survival Analysis; D015854:Up-Regulation; D020741:rho GTP-Binding Proteins / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; C508705:RND3 protein, human; D020741:rho GTP-Binding Proteins