Inhibition of type III secretion in Salmonella enterica serovar Typhimurium by small-molecule inhibitors.
Type III secretion systems (T3SS) are conserved in many pathogenic gram-negative bacteria. Small molecules that specifically target T3SS in Yersinia and Chlamydia spp. have recently been identified. Here we show that two such compounds inhibit Salmonella T3SS-1, preventing secretion of T3SS-1 effectors, invasion of cultured epithelial cells, and enteritis in vivo.
Hudson
Debra L
DL
Division of Microbiology, Institute for Animal Health, Compton, Berkshire RG20 7NN, United Kingdom.
Layton
Abigail N
AN
Field
Terry R
TR
Bowen
Alison J
AJ
Wolf-Watz
Hans
H
Elofsson
Mikael
M
Stevens
Mark P
MP
Galyov
Edouard E
EE
D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism*; D002417:Cattle; D004305:Dose-Response Relationship, Drug; D015394:Molecular Structure; D012486:Salmonella typhimurium / Q000145:classification / Q000378:metabolism* / Q000472:pathogenicity*; D012703:Serotyping
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins