Downregulation of the beta1,3- galactosyltransferase gene in tonsillar B lymphocytes and aberrant lectin bindings to tonsillar IgA as a pathogenesis of IgA nephropathy.
IgA is a glycoprotein with multiple O-glycans. Under-O-glycosylation of the hinge in IgA in patients with IgA nephropathy (IgAN) is reported. The development of IgAN is frequently preceded by episodes of upper respiratory tract infections such as tonsillitis. Therefore, the tonsils may be related to the pathogenesis of IgAN. However, the mechanism of underglycosylation in tonsillar IgA has not yet been fully elucidated. Since O-glycans in IgA are produced by glycosyltransferases, we hypothesized that dysregulation of the enzymes is associated with underglycosylation.
Inoue
Tatsuyuki
T
Departmentsof Medicine and Clinical Science Okayama University Graduate School of Medicine, Okayama, Japan.
Sugiyama
Hitoshi
H
Kikumoto
Yoko
Y
Fukuoka
Naomi
N
Maeshima
Yohei
Y
Hattori
Hisashi
H
Fukushima
Kunihiro
K
Nishizaki
Kazunori
K
Hiki
Yoshiyuki
Y
Makino
Hirofumi
H
D001402:B-Lymphocytes / Q000201:enzymology* / Q000276:immunology; D001706:Biopsy; D015536:Down-Regulation / Q000276:immunology; D005700:Galactosyltransferases; D015971:Gene Expression Regulation, Enzymologic; D005922:Glomerulonephritis, IGA / Q000276:immunology* / Q000378:metabolism* / Q000473:pathology; D005964:Glucosyltransferases / Q000235:genetics* / Q000378:metabolism; D006031:Glycosylation; D006801:Humans; D007070:Immunoglobulin A / Q000276:immunology / Q000378:metabolism*; D037102:Lectins / Q000378:metabolism; D014066:Palatine Tonsil / Q000166:cytology* / Q000276:immunology
D007070:Immunoglobulin A; D037102:Lectins; C514116:B3GLCT protein, human; D005700:Galactosyltransferases; D005964:Glucosyltransferases