title: Corticosterone fails to produce conditioned place preference or conditioned place aversion in rats.
abstract: BACKGROUND
  In some rats, the hormone corticosterone is reinforcing. High novelty-seeking rats (high responders, HR) self-administered corticosterone at a much higher rate than low novelty-seeking rats (low responders, LR) do [Piazza PV, Deroche V, Deminiere JM, Maccari S, Le Moal M, Simon H, Corticosterone in the range of stress-induced levels possesses reinforcing properties: implications for sensation-seeking behaviors, Proc Natl Acad Sci USA 1993;90:11738-42]. While previous studies demonstrated that corticosterone reinforces nose poking in a self-administration paradigm, no studies to date have examined whether corticosterone is rewarding.
  
  
  OBJECTIVE
  Using the conditioned place preference (CPP) paradigm, we examined the rewarding effects of corticosterone in HR and LR rats.
  
  
  METHODS
  Male Sprague-Dawley rats were classified into HR and LR groups based on their locomotor activity in a novel environment. Subsequently, independent groups of HR and LR rats underwent CPP for corticosterone (0, 2.5 or 10 mg/kg; i.p.) or cocaine (12 mg/kg; i.p). CPP for cocaine was used as a positive control.
  
  
  RESULTS
  While cocaine produced a strong CPP in both HR and LR rats, corticosterone failed to produce either preference or aversion in both phenotypes.
  
  
  CONCLUSIONS
  Corticosterone is neither rewarding nor aversive in either behavioral phenotype.
authors.affiliation: Florida State University, College of Medicine, Department of Biomedical Sciences, Program in Neuroscience, Tallahassee, FL 32306-4300, United States.
authors.forename: David
authors.initials: D
authors.lastname: Dietz
authors.forename: Hui
authors.initials: H
authors.lastname: Wang
authors.forename: Mohamed
authors.initials: M
authors.lastname: Kabbaj
mesh_terms: D000818:Animals; D001245:Association Learning / Q000187:drug effects*; D001362:Avoidance Learning / Q000187:drug effects*; D003042:Cocaine / Q000494:pharmacology*; D003214:Conditioning, Classical / Q000187:drug effects; D003345:Corticosterone / Q000494:pharmacology*; D018765:Dopamine Uptake Inhibitors / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004777:Environment; D005106:Exploratory Behavior / Q000187:drug effects; D006728:Hormones / Q000494:pharmacology; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D012201:Reward
chemical_list: D018765:Dopamine Uptake Inhibitors; D006728:Hormones; D003042:Cocaine; D003345:Corticosterone