New experimental markers for early detection of high-risk prostate cancer: role of cell-cell adhesion and cell migration.
Today's treatment and diagnosis of prostate cancer still exhibit major limitations. The search for new and additional prognostic markers is therefore still an actual field of interest. Potential markers involved in numerous biological processes in the tumor cell have been investigated intensively. For therapeutic interventions it is important to distinguish between harmless and aggressive disease in an early stage. Therefore the subject of this review is limited to markers associated with those functional processes, which discriminate early stage aggressive, metastatic cancer from harmless disease. Important processes in this respect are: altered cell adhesion and cellular migration. E-cadherin, N-cadherin, beta-catenin, integrins, focal adhesion kinase, connexins and matrix metalloproteinases all appear promising biological markers associated with the early stage metastatic process in prostate cancer. Here we discuss their potential to become valid biological markers based on literature data. Thus far, none of these markers proved to be a valid individual marker by itself due to prostate cancer heterogeneity and transient expression. Analyzing a combination of the potential markers discussed in this review is expected to be a better approach toward discriminating high- from low-risk tumors in an early stage of prostate cancer.
Mol
A J M
AJ
Department of Urology, VU University Medical Center, PO Box 7057, 1007, MB, Amsterdam, The Netherlands. A.mol@VUMC.nl
Geldof
A A
AA
Meijer
G A
GA
van der Poel
H G
HG
van Moorselaar
R J A
RJ
D000818:Animals; D014408:Biomarkers, Tumor / Q000032:analysis*; D002448:Cell Adhesion / Q000502:physiology*; D002465:Cell Movement / Q000502:physiology*; D006801:Humans; D008297:Male; D009361:Neoplasm Invasiveness / Q000503:physiopathology*; D011471:Prostatic Neoplasms / Q000175:diagnosis*
D014408:Biomarkers, Tumor