Medicinal studies of dimeric phenols with multiple quaternary-ammonium pendant arms.
A series of biphenol-derived quaternary ammonium salts, originally developed as DNA-cross-linking agents, and carrying either two (i.e., 1) or four (i.e., 2) net positive charges, were investigated for their in vitro DNA-transcription- and acetylcholinesterase (AChE)-inhibitory activities. The effects of charge and type of linker between the two phenolic residues were systematically investigated. Several compounds showed good activities in both tests, which makes them potential lead candidates for drug design.
Tian
Tian
T
College of Chemistry and Molecular Sciences, Wuhan University, Hubei, Wuhan 430072, PR China.
Weng
Xiao-Cheng
XC
Song
Yang
Y
Zhang
Li-Xia
LX
Zhou
Xiang
X
Wang
Yi
Y
D000110:Acetylcholinesterase / Q000378:metabolism*; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D019281:Dimerization; D015195:Drug Design; D010636:Phenols / Q000737:chemistry*; D000644:Quaternary Ammonium Compounds / Q000737:chemistry / Q000494:pharmacology*
D002800:Cholinesterase Inhibitors; D010636:Phenols; D000644:Quaternary Ammonium Compounds; D000110:Acetylcholinesterase