Colchicine overdose-induced acute renal failure and electrolyte imbalance.
Colchicine has been used to control gouty arthritis for long time; colchicine overdose, however, causes multiple organ dysfunction. To date, no investigation has revealed the site of kidney lesion or dysfunction. This investigation describes the case of a male with a history of gout who ingested a large amount of colchicine and developed renal, hematopoietic, gastrointestinal, muscular, electrolytic, and hepatic disorder. Glucosuria was noted during hospital days. Colchicine intoxication is shown to induce proximal tubule damage. Severe electrolytes imbalance was noted, including hypomagnesemia, hypophosphatemia, and hypocalcemia. After management, the renal function and serum electrolyte of the patient recovered on the sixth day of hospitalization.
Huang
Wen-Hung
WH
Department of Nephrology, Chang Gung Memorial Hospital, Linkou, Taiwan, ROC.
Hsu
Ching-Wei
CW
Yu
Chun-Chen
CC
D058186:Acute Kidney Injury / Q000139:chemically induced*; D015210:Arthritis, Gouty / Q000188:drug therapy; D003078:Colchicine / Q000009:adverse effects*; D062787:Drug Overdose; D006074:Gout Suppressants / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000139:chemically induced; D014883:Water-Electrolyte Imbalance / Q000139:chemically induced*
D006074:Gout Suppressants; D003078:Colchicine