title: The MiniACcor: constructive redesign of an implantable total artificial heart, initial laboratory testing and further steps.
abstract: The Aachen Total Artificial Heart (ACcor) has been under development at the Helmholtz Institute in Aachen over the last decade. It may serve as a bridge to transplant or as a long-term replacement of the natural heart. Based upon previous in vivo experiments with the ACcor total artificial heart, it was decided to optimize and redesign the pump unit. Smaller dimensions, passive filling and separability into three components were the three main design goals. The new design is called the MiniACcor, which is about 20% smaller than its predecessor, and weighs only 470 grams. Also its external driver/control unit was miniaturized and a new microcontroller was selected. To validate the design, it was extensively tested in laboratory mock loops. The MiniACcor was able to pump between 4.5 and 7 l/min at different pump rates against normal physiological pressures. Several requirements for the future compliance chamber and transcutaneous energy transmission (TET) system were also measured in the same mock loop. Further optimization and validation are being performed in cooperation with the Heart and Diabetes Centre North Rhine-Westphalia.
authors.affiliation: Helmholtz Institute, Aachen, Germany. kwant@hia.rwth-aachen.de
authors.forename: P B
authors.initials: PB
authors.lastname: Kwant
authors.forename: T
authors.initials: T
authors.lastname: Finocchiaro
authors.forename: F
authors.initials: F
authors.lastname: Förster
authors.forename: H
authors.initials: H
authors.lastname: Reul
authors.forename: G
authors.initials: G
authors.lastname: Rau
authors.forename: M
authors.initials: M
authors.lastname: Morshuis
authors.forename: A
authors.initials: A
authors.lastname: El Banayosi
authors.forename: R
authors.initials: R
authors.lastname: Körfer
authors.forename: T
authors.initials: T
authors.lastname: Schmitz-Rode
authors.forename: U
authors.initials: U
authors.lastname: Steinseifer
mesh_terms: D000818:Animals; D001011:Aorta / Q000601:surgery; D001698:Biomedical Engineering / Q000295:instrumentation; D002306:Cardiac Volume / Q000502:physiology; D002417:Cattle; D006325:Heart Atria / Q000601:surgery; D006354:Heart, Artificial; D006801:Humans; D008904:Miniaturization; D011140:Polyurethanes / Q000737:chemistry; D011143:Polyvinyl Chloride / Q000737:chemistry; D011474:Prosthesis Design; D011651:Pulmonary Artery / Q000601:surgery; D013318:Stroke Volume / Q000502:physiology
chemical_list: D011140:Polyurethanes; D011143:Polyvinyl Chloride