Muscle phosphocreatine post-exercise recovery rate is related to functional evaluation in hospitalized and community-living older people.
OBJECTIVE
to explore muscle mitochondria function with respect to age, functional status and nutrition in community-living and recovering hospitalized older subjects.


METHODS
subjects were assessed for nutrition, hand-grip strength, 10-meter gait time, a modified timed get-up-and-go test and activities of daily living score (ADL). 31P magnetic resonance spectroscopy (31P MRS) was used to assess the initial rate of post-exercise phosphocreatine recovery (ViPCr) for mitochondrial function evaluation in 25 hospitalized older subjects (86.1 + 5.3 y) and in 25 community-living younger ones (74.5 + 6.2 y).


RESULTS
in multiple linear regression, longer time on the get-up-and-go test was independently associated with lower values of ViPCr (p = 0.008). For all subjects and in the 8 patients unable to perform this test, ViPCr was negatively correlated with the ADL score (respectively p < 0.001 and p = 0.025).


CONCLUSIONS
particularly in hospitalized and frail older subjects, muscle mitochondrial function was related to the global physical functional assessment.
Bourdel-Marchasson
I
I
Departement de Geriatrie, Hopital Xavier Arnozan, Avenue du Haut-Leveque, 33604 Pessac cedex, France. isabelle.bourdel-marchasson@chu-bordeaux.fr
Biran
M
M
Dehail
P
P
Traissac
T
T
Muller
F
F
Jenn
J
J
Raffard
G
G
Franconi
J M
JM
Thiaudiere
E
E
D000203:Activities of Daily Living; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology; D005260:Female; D005684:Gait / Q000502:physiology; D015577:Geriatric Assessment; D018737:Hand Strength; D006305:Health Status Indicators; D006760:Hospitalization; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008297:Male; D008931:Mitochondria, Muscle / Q000378:metabolism*; D015596:Nutrition Assessment; D010725:Phosphocreatine / Q000378:metabolism*
D010725:Phosphocreatine