Aqueous ginger extract ameliorates paraben induced cytotoxicity.
The present investigation is an attempt to examine the ameliorative effect of aqueous ginger extract on cytotoxicity induced by paraben (p-hydroxybenzoic acid) on red blood cells (RBC) in vitro. Blood samples collected in EDTA vials from healthy adult human beings (25-30 years) were used for preparation of RBC suspension in saline. The saline suspension of RBC was treated with paraben with and without ginger extracts. The results revealed that addition of paraben to RBC suspension caused significant increase in the rate of hemolysis. However, concurrent addition of paraben (150 microg/mL) and ginger extract caused significant concentration-dependent retardation in paraben-induced hemolysis. The decrease in hemolysis was almost dose-
Asnani
Veena
V
Department of Zoology, University School of Sciences, Gujarat University, Ahmedabad 380009, India. zooldeptgu@satyam.net.in
Verma
Ramtej Jayram
RJ
D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000166:cytology / Q000187:drug effects*; D020939:Zingiber officinale / Q000737:chemistry*; D006461:Hemolysis / Q000187:drug effects*; D006801:Humans; D010226:Parabens / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D014867:Water / Q000737:chemistry
D010226:Parabens; D010936:Plant Extracts; D014867:Water