Influence of binder type on interacting variables acting on mechanical properties of a sulfadimidine tablet formulation.
A study of the quantitative effect of type of binder (N), applied pressure (P), and granular size (G) on two mechanical properties-tensile strength (TS) and brittle fracture index (BFI) - of a sulfadimidine tablet formulation has been carried out by using a 2(3) factorial experimental design. The results obtained from this work suggest that P exhibited the largest individual effect on TS and BFI. It is also seen from this work that the nature of binders in combination affects the influence that P and G had on the TS or BFI.
Alebiowu
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Department of Pharmaceutics, Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife, Nigeria. galebiowu@oauife.edu.ng
Ojeleye
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D000890:Anti-Infective Agents / Q000737:chemistry*; D031622:Artocarpus / Q000737:chemistry; D002626:Chemistry, Pharmaceutical; D004548:Elasticity; D005079:Excipients / Q000737:chemistry*; D005780:Gelatin / Q000737:chemistry; D028521:Musa / Q000737:chemistry; D011312:Pressure; D013213:Starch / Q000737:chemistry / Q000302:isolation & purification; D013418:Sulfamethazine / Q000737:chemistry*; D013607:Tablets; D013678:Technology, Pharmaceutical / Q000379:methods*; D013718:Tensile Strength
D000890:Anti-Infective Agents; D005079:Excipients; D013607:Tablets; D013418:Sulfamethazine; D005780:Gelatin; D013213:Starch