title: Specific regional distribution of protein arginine methyltransferase 8 (PRMT8) in the mouse brain.
abstract: The regional distribution of PRMT8 transcript was examined in mouse brain using in situ hybridization (ISH) histochemistry. The PRMT8 cRNA probe was specifically hybridized with CNS and the signals were observed only in the neurons. The distribution of the neurons expressing PRMT8 mRNA was not even throughout the brain. All of the regions related to general somatosensory system expressed PRMT8 mRNA strongly. Most of the relay nuclei intervening the special somatosensory system, such as the auditory, visual, and vestibular systems, were packed with PRMT8 mRNA expressing neurons. Forebrain limbic areas and thalamic nuclei relevant to limbic areas were also strongly labeled with the probe. Some areas related to the motor system, such as the caudate putamen, Purkinje cells, inferior olivary nucleus and cerebellar nuclei expressed PRMT8 mRNA strongly. These findings suggest that PRMT8 is chiefly involved in the somatosensory and limbic systems, and a part of motor system.
authors.affiliation: Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka, Japan.
authors.forename: Tsuya
authors.initials: T
authors.lastname: Taneda
authors.forename: Shingo
authors.initials: S
authors.lastname: Miyata
authors.forename: Aoi
authors.initials: A
authors.lastname: Kousaka
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Inoue
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Koyama
authors.forename: Yasutake
authors.initials: Y
authors.lastname: Mori
authors.forename: Masaya
authors.initials: M
authors.lastname: Tohyama
mesh_terms: D000679:Amygdala / Q000201:enzymology; D000818:Animals; D001921:Brain / Q000196:embryology / Q000201:enzymology*; D002531:Cerebellum; D002540:Cerebral Cortex / Q000201:enzymology; D005260:Female; D017403:In Situ Hybridization; D008032:Limbic System / Q000201:enzymology; D051379:Mice; D009474:Neurons / Q000201:enzymology*; D009830:Olfactory Bulb / Q000201:enzymology; D009833:Olfactory Pathways / Q000201:enzymology; D011247:Pregnancy; D011499:Protein Processing, Post-Translational; D011484:Protein-Arginine N-Methyltransferases / Q000235:genetics / Q000378:metabolism*; D012333:RNA, Messenger / Q000235:genetics; D013003:Somatosensory Cortex / Q000201:enzymology
chemical_list: D012333:RNA, Messenger; D011484:Protein-Arginine N-Methyltransferases