The COMT Val158Met polymorphism and temporal lobe morphometry in healthy adults.
We examined the relationship between COMT Val158Met genotype and temporal lobe volumes, including the caudate as a control region. Thirty-one healthy subjects completed 1.5T brain MRI and genotyping. After controlling for demographics, Val158 allele homozygotes exhibited significantly smaller temporal lobe and hippocampal volumes, with a trend for smaller amygdala volumes.
Taylor
Warren D
WD
Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA. Taylo066@mc.duke.edu
Züchner
Stephan
S
Payne
Martha E
ME
Messer
Denise F
DF
Doty
Tracy J
TJ
MacFall
James R
JR
Beyer
John L
JL
Krishnan
K Ranga R
KR
D000328:Adult; D000679:Amygdala / Q000033:anatomy & histology / Q000378:metabolism; D001921:Brain / Q000033:anatomy & histology / Q000201:enzymology / Q000378:metabolism; D002394:Catechol O-Methyltransferase / Q000235:genetics* / Q000378:metabolism; D002421:Caudate Nucleus / Q000033:anatomy & histology / Q000201:enzymology / Q000378:metabolism; D005260:Female; D007839:Functional Laterality / Q000235:genetics; D005838:Genotype; D006720:Homozygote; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000706:statistics & numerical data*; D008297:Male; D008715:Methionine / Q000235:genetics / Q000378:metabolism; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D013702:Temporal Lobe / Q000033:anatomy & histology* / Q000201:enzymology / Q000378:metabolism; D014633:Valine / Q000235:genetics / Q000378:metabolism
D008715:Methionine; D002394:Catechol O-Methyltransferase; D014633:Valine