title: Vaccine-associated paralytic poliomyelitis in a patient with MHC class II deficiency.
abstract: Vaccine-associated paralytic poliomyelitis (VAPP) is a rare complication of oral polio vaccine. We describe a fatal case of VAPP in an 8-month-old boy with Major Histocompatibility Class II deficiency. The isolated poliovirus was a Sabin type 2-type 1 recombinant that showed 1.4% VP1 divergence from Sabin type 2.
authors.affiliation: Department of Pediatrics, Infectious Disease Research Center, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Nima
authors.initials: N
authors.lastname: Parvaneh
authors.forename: Shohreh
authors.initials: S
authors.lastname: Shahmahmoudi
authors.forename: Hamideh
authors.initials: H
authors.lastname: Tabatabai
authors.forename: Mohsen
authors.initials: M
authors.lastname: Zahraei
authors.forename: Taha
authors.initials: T
authors.lastname: Mousavi
authors.forename: Abdol-Reza
authors.initials: AR
authors.lastname: Esteghamati
authors.forename: Mohammad M
authors.initials: MM
authors.lastname: Gooya
authors.forename: Setareh
authors.initials: S
authors.lastname: Mamishi
authors.forename: Rakhshandeh
authors.initials: R
authors.lastname: Nategh
authors.forename: Olen M
authors.initials: OM
authors.lastname: Kew
mesh_terms: D004797:Enzyme-Linked Immunosorbent Assay; D017809:Fatal Outcome; D000949:Histocompatibility Antigens Class II; D006801:Humans; D016867:Immunocompromised Host; D007153:Immunologic Deficiency Syndromes / Q000150:complications*; D007223:Infant; D008297:Male; D011051:Poliomyelitis / Q000209:etiology* / Q000517:prevention & control; D011055:Poliovirus Vaccine, Oral / Q000009:adverse effects* / Q000276:immunology; D016133:Polymerase Chain Reaction
chemical_list: D000949:Histocompatibility Antigens Class II; D011055:Poliovirus Vaccine, Oral