Mitochondrial energy metabolism and redox state in dyslipidemias.
Changes in mitochondrial function are intimately associated with metabolic diseases. Here, we review recent evidence relating alterations in mitochondrial energy metabolism, ion transport and redox state in hypercholesterolemia and hypertriglyceridemia. We focus mainly on changes in mitochondrial respiration, K(+) and Ca(2+) transport, reactive oxygen species generation and susceptibility to mitochondrial permeability transition.
Vercesi
Anibal E
AE
Departamento de Patologia Clínica, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Campinas, Brazil. anibal@unicamp.br
Castilho
Roger F
RF
Kowaltowski
Alicia J
AJ
Oliveira
Helena C F
HC
D004734:Energy Metabolism; D006937:Hypercholesterolemia / Q000378:metabolism*; D015228:Hypertriglyceridemia / Q000378:metabolism*; D054086:KATP Channels / Q000378:metabolism; D008928:Mitochondria / Q000378:metabolism*; D009249:NADP / Q000378:metabolism; D010084:Oxidation-Reduction
D054086:KATP Channels; D009249:NADP