title: Successful term pregnancy in a patient with Wegener's granulomatosis: case report and literature review.
abstract: OBJECTIVE
  To present a case of successful term pregnancy in a patient with known Wegener's granulomatosis (WG).
  
  
  METHODS
  Case report.
  
  
  METHODS
  University Hospital, Department of Obstetrics and Gynecology.
  
  
  METHODS
  A 22-year-old primigravida pregnant woman with a history of WG diagnosed 5 years before.
  
  
  METHODS
  The patient was treated with corticosteroids and azathioprine throughout pregnancy, and cyclophosphamide was added postpartum.
  
  
  METHODS
  The disease was in partial remission at the onset of pregnancy, but two relapses occurred, at 33 weeks' gestation and 15 days after delivery. A 3150-g healthy boy was delivered at 37 weeks' gestation.
  
  
  CONCLUSIONS
  Pregnancy in patients with WG requires preconceptional planning, careful clinical management, and vigorous treatment of active disease. There are 36 cases of WG in pregnancy reported in the literature. Owing to this rarity, the management is individualized and the pregnancy outcome is variable. Antenatal management and therapeutic options are discussed and a short review of the literature is presented.
authors.affiliation: Department of Obstetrics-Gynecology, University Hospital of Heraklion, Crete, Greece.
authors.forename: Ourania
authors.initials: O
authors.lastname: Koukoura
authors.forename: Nikitas
authors.initials: N
authors.lastname: Mantas
authors.forename: Haralabos
authors.initials: H
authors.lastname: Linardakis
authors.forename: Jiannis
authors.initials: J
authors.lastname: Hajiioannou
authors.forename: Stavros
authors.initials: S
authors.lastname: Sifakis
mesh_terms: D000305:Adrenal Cortex Hormones / Q000008:administration & dosage*; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage; D001379:Azathioprine / Q000008:administration & dosage*; D005260:Female; D014890:Granulomatosis with Polyangiitis / Q000150:complications* / Q000188:drug therapy*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis / Q000188:drug therapy*; D011256:Pregnancy Outcome; D047929:Term Birth; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones; D000893:Anti-Inflammatory Agents; D001379:Azathioprine