Gelatin colloids in the resuscitation of trauma.
To date, the specific role of gelatins in trauma resuscitation remains under-investigated. Their adverse affects are well described and relate principally to the provocation of allergic responses whilst their influence upon haemostasis is relatively benign in comparison to the other colloids. However, their benefits are only sparsely documented and the evidence to choose one gelatin over another virtually non-existent. As knowledge of the microcirculatory dysfunction inherent in the shocked state increases, the role of the gelatins in trauma resuscitation is being increasing sidelined by other colloids--notably the starches. Their role beyond a basic resuscitation tool is now uncertain.
Whitfield
C
C
Northern General Hospital, Sheffield. cwhitfield@doctors.org.uk
D003102:Colloids / Q000009:adverse effects / Q000627:therapeutic use*; D005780:Gelatin / Q000009:adverse effects / Q000627:therapeutic use*; D006487:Hemostasis / Q000187:drug effects; D006801:Humans; D012151:Resuscitation; D012774:Shock, Traumatic / Q000503:physiopathology / Q000628:therapy; D014947:Wounds and Injuries / Q000503:physiopathology / Q000628:therapy*
D003102:Colloids; D005780:Gelatin