Muscle intermediate filaments and their links to membranes and membranous organelles.
Intermediate filaments (IFs) play a key role in the integration of structure and function of striated muscle, primarily by mediating mechanochemical links between the contractile apparatus and mitochondria, myonuclei, the sarcolemma and potentially the vesicle trafficking apparatus. Linkage of all these membranous structures to the contractile apparatus, mainly through the Z-disks, supports the integration and coordination of growth and energy demands of the working myocyte, not only with force transmission, but also with de novo gene expression, energy production and efficient protein and lipid trafficking and targeting. Desmin, the most abundant and intensively studied muscle intermediate filament protein, is linked to proper costamere organization, myoblast and stem cell fusion and differentiation, nuclear shape and positioning, as well as mitochondrial shape, structure, positioning and function. Similar links have been established for lysosomes and lysosome-related organelles, consistent with the presence of widespread links between IFs and membranous structures and the regulation of their fusion, morphology and stabilization necessary for cell survival.
Capetanaki
Yassemi
Y
Cell Biology Division, Center of Basic Research, Biomedical Research Foundation Academy of Athens, Soranou Efessiou 4, 12965 Athens, Greece. ycapetanaki@bioacademy.gr
Bloch
Robert J
RJ
Kouloumenta
Asimina
A
Mavroidis
Manolis
M
Psarras
Stelios
S
D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D003893:Desmin / Q000235:genetics / Q000378:metabolism; D006801:Humans; D007382:Intermediate Filaments / Q000378:metabolism* / Q000648:ultrastructure; D007425:Intracellular Membranes / Q000378:metabolism* / Q000648:ultrastructure; D008928:Mitochondria / Q000378:metabolism; D018482:Muscle, Skeletal / Q000378:metabolism* / Q000648:ultrastructure; D009135:Muscular Diseases / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology; D032446:Myoblasts / Q000378:metabolism / Q000648:ultrastructure; D015388:Organelles / Q000378:metabolism* / Q000648:ultrastructure
D003893:Desmin