title: Cardioprotection in females: a role for nitric oxide and altered gene expression.
abstract: A number of epidemiological and animal studies have suggested a cardioprotective role for estrogen. This review will focus on the cardioprotective role of estrogen in ischemia-reperfusion injury. Estrogen binding to receptors can lead to altered gene expression and estrogen has been shown to induce expression of a number of genes that have been suggested to be important in cardioprotection. Estrogen is reported to increase expression of the plasma membrane glucose transporter GLUT4 and to increase carbohydrate metabolism. Estrogen has also been reported to increase mitochondrial biogenesis and to alter mitochondrial generation of reactive oxygen species. Estrogen results in upregulation of cardiac eNOS and nNOS, which have been shown previously to be important mediators of cardioprotection. Nitric oxide has been shown to result in S-nitrosylation and inhibition of the L-type calcium channel, thereby reducing calcium loading during ischemia. Nitric oxide has also been reported to inhibit complex I and inhibition of complex I has been reported to reduce activation of the mitochondrial permeability transition pore. Nitric oxide has been shown to result in activation of the mitochondrial K(ATP) channel, which has been shown to be involved in cardioprotection. Estrogen can also activate rapid non-genomic pathways that activate cardioprotective-signaling pathways such as the phosphatidylinositol-3-kinase (PI-3 kinase) pathway which has also been shown to initiate protection. Taken together, estrogen by genomic and non-genomic pathways can result in the initiation of a number of signaling pathways that enhance cardioprotection.
authors.affiliation: Head Cardiac Physiology Section, Vascular Medicine Branch, National Heart, Lung, and Blood Institute/NIH, 10 Center Drive, Bethesda, MD 20892, USA. murphy1@niehs.nih.gov
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Murphy
authors.forename: Charles
authors.initials: C
authors.lastname: Steenbergen
mesh_terms: D004967:Estrogens / Q000502:physiology*; D005260:Female; D015870:Gene Expression; D006801:Humans; D008928:Mitochondria; D033681:Mitochondrial Membrane Transport Proteins; D000083162:Mitochondrial Permeability Transition Pore; D009203:Myocardial Infarction / Q000150:complications / Q000503:physiopathology; D017202:Myocardial Ischemia / Q000235:genetics / Q000503:physiopathology / Q000517:prevention & control*; D015425:Myocardial Reperfusion; D009569:Nitric Oxide / Q000502:physiology*; D019001:Nitric Oxide Synthase; D012737:Sex Factors; D015398:Signal Transduction
chemical_list: D004967:Estrogens; D033681:Mitochondrial Membrane Transport Proteins; D000083162:Mitochondrial Permeability Transition Pore; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase