Coupling of c-fos expression in the spinal cord and amygdala induced by dorsal neck muscles fatigue.
c-fos gene expression in the cervical spinal cord and amygdala was examined in anaesthetized rats following muscle fatigue caused by intermittent high-rate (100 s(-1)) electrical stimulation of the dorsal neck muscles (m. trapezius and m. splenius). Fatigue-related increases in c-fos expression were observed on the stimulated muscle side in the cervical C2-C4 (layers 1, 3-5, 7 and 10) spinal segments, bilaterally in the lumbar L4-L6 (layer 1) segments and in contralateral central (Ce), medial (Me), and basomedial (BM) amygdaloid nuclei. A scarce number of staining cells were found within lateral and basolateral nuclei. The rostro-caudal extent of c-fos expression in the spinal cord supports functional coupling of the cervical and lumbar regions during the neck muscle fatigue development. The distinct c-fos expression in the Ce and Me amygdaloid nuclei suggests that they may contribute to mediating the neck muscle fatigue-related nociception, autonomic and behavioural responses.
Maznychenko
Andrey V
AV
Department of Movement Physiology, Bogomoletz Institute of Physiology, National Academy of Sciences, Bogomoletz str. 4, Kiev 01024, Ukraine. maznychenko@biph.kiev.ua
Pilyavskii
Alexander I
AI
Kostyukov
Alexander I
AI
Lyskov
Eugene
E
Vlasenko
Oleh V
OV
Maisky
Vladimir A
VA
D000679:Amygdala / Q000378:metabolism*; D000818:Animals; D001341:Autonomic Nervous System / Q000502:physiology; D001522:Behavior, Animal / Q000502:physiology; D004558:Electric Stimulation; D015870:Gene Expression / Q000502:physiology*; D016762:Genes, fos / Q000235:genetics*; D007150:Immunohistochemistry; D008297:Male; D009119:Muscle Contraction / Q000502:physiology; D018763:Muscle Fatigue / Q000502:physiology*; D009334:Neck Muscles / Q000502:physiology*; D009619:Nociceptors / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D013116:Spinal Cord / Q000378:metabolism*