title: Generalized vasculitic exanthem following Loxosceles reclusa envenomation.
abstract: Brown recluse spider bites (BRSB) cause a myriad of reactions ranging from local necrosis to potentially lethal systemic involvement. Envenomation may induce a generalized exanthem known clinically but not described histologically. We report a 49-year-old female who developed a generalized exanthem 24 hours after BRSB. The histopathology demonstrated a necrotizing vasculitis similar to that seen at an envenomation site but without epidermal necrosis. Loxoscelism should be considered in patients residing in endemic areas who present with a vasculitic exanthem.
authors.affiliation: Division of Dermatology, Department of Internal Medicine, Vanderbilt University, Nashville, TN 37232, USA.
authors.forename: Christopher W
authors.initials: CW
authors.lastname: Robb
authors.forename: Benjamin B
authors.initials: BB
authors.lastname: Hayes
authors.forename: Alan S
authors.initials: AS
authors.lastname: Boyd
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001241:Aspirin / Q000627:therapeutic use; D017679:Cryotherapy; D003622:Dapsone / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005076:Exanthema / Q000209:etiology / Q000473:pathology* / Q000628:therapy; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged; D009336:Necrosis; D010727:Phosphoric Diester Hydrolases / Q000506:poisoning*; D011312:Pressure; D012146:Rest; D001098:Spider Bites / Q000209:etiology / Q000473:pathology* / Q000628:therapy; D013111:Spider Venoms / Q000506:poisoning*; D013112:Spiders / Q000472:pathogenicity*; D014657:Vasculitis / Q000209:etiology / Q000473:pathology / Q000628:therapy
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D005938:Glucocorticoids; D013111:Spider Venoms; C055161:loxosceles venom; D003622:Dapsone; D010727:Phosphoric Diester Hydrolases; D001241:Aspirin; D008775:Methylprednisolone