Mitochondrial medicine: pharmacological targeting of mitochondria in disease.
Mitochondria play a central role in cell life and death and are known to be important in a wide range of diseases including the cancer, diabetes, cardiovascular disease, and the age-related neurodegenerative diseases. The unique structural and functional characteristics of mitochondria enable the selective targeting of drugs designed to modulate the function of this organelle for therapeutic gain. This review discusses mitochondrial drug targeting strategies and a variety of novel mitochondrial drug targets including the electron transport chain, mitochondrial permeability transition, Bcl-2 family proteins and mitochondrial DNA. Mitochondrial drug-targeting strategies will open up avenues for manipulating mitochondrial functions and allow for selective protection or eradication of cells for therapeutic gain in a variety of diseases.
Armstrong
J S
JS
Department of Biochemistry, Faculty of Medicine, National University of Singapore, 8 Medical Drive, Singapore 117597, Singapore.
D017209:Apoptosis / Q000502:physiology; D004272:DNA, Mitochondrial / Q000187:drug effects / Q000502:physiology; D016503:Drug Delivery Systems; D004579:Electron Transport / Q000187:drug effects / Q000502:physiology; D006801:Humans; D008928:Mitochondria / Q000187:drug effects* / Q000473:pathology; D028361:Mitochondrial Diseases / Q000188:drug therapy* / Q000503:physiopathology; D010539:Permeability / Q000187:drug effects; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000187:drug effects / Q000502:physiology
D004272:DNA, Mitochondrial; D019253:Proto-Oncogene Proteins c-bcl-2