[The influence of 3-oxypyridine antioxidants on depression in patients with diabetes mellitus].
The authors studied the influence of 3-oxypyridine derivates (emoxypine and mexidol) on the degree of depressive symptoms in patients with diabetes mellitus; the data were matched with the dynamics of blood lipoperoxidation. The study found that administration of emoxypine (150 mg every day) or mexidol (300 mg a day) during 14 days lowered the level of circulating lipoperoxidation products and diminished manifestations of depression, which was accompanied by improvement in cognitive functions and quality of life; the degree of the changes was similar. These clinical effects of 3-oxypyridine derivates were independent of the dynamics of glycemia and lipidemia.
Volchegorskiĭ
I A
IA
Mester
N V
NV
D000328:Adult; D000975:Antioxidants / Q000627:therapeutic use*; D003865:Major Depressive Disorder / Q000188:drug therapy* / Q000453:epidemiology*; D003920:Diabetes Mellitus / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010847:Picolines / Q000627:therapeutic use*; D011446:Prospective Studies; D011725:Pyridines / Q000627:therapeutic use*
C457919:3-oxypyridine; D000975:Antioxidants; D010847:Picolines; D011725:Pyridines; C070020:emoxypine succinate; C009820:6-methyl-2-ethyl-3-hydroxypyridine