title: Corticosterone inhibits the lipid-mobilizing effects of oleoyl-estrone in adrenalectomized rats.
abstract: Oleoyl-estrone (OE) is an adipose-derived signal that decreases energy intake and body lipid, maintaining energy expenditure and glycemic homeostasis. Glucocorticoids protect body lipid and the metabolic status quo. We studied the combined effects of OE and corticosterone in adrenalectomized female rats: daily OE gavages (0 or 10 nmol/g) and slow-release corticosterone pellets at four doses (0, 0.5, 1.7, and 4.8 mg/d). Intact and sham-operated controls were also included. After 8 d, body composition and plasma metabolites and hormones were measured. OE induced a massive lipid mobilization (in parallel with decreased food intake and maintained energy expenditure). Corticosterone increased fat deposition and inhibited the OE-elicited mobilization of body energy, even at the lowest dose. OE enhanced the corticosterone-induced rise in plasma triacylglycerols, and corticosterone blocked the OE-induced decrease in leptin. High corticosterone and OE increased insulin resistance beyond the effects of corticosterone alone. The presence of corticosterone dramatically affected OE effects, reversing its decrease of body energy (lipid) content, with little or no change on food intake or energy expenditure. The maintenance of glycemia and increasing insulin in parallel to the dose of corticosterone indicate a decrease in insulin sensitivity, which is enhanced by OE. The reversal of OE effects on lipid handling, insulin resistance, can be the consequence of a corticosterone-induced OE resistance. Nevertheless, OE effects on cholesterol were largely unaffected. In conclusion, corticosterone administration effectively blocked OE effects on body lipid and energy balance as well as insulin sensitivity and glycemia.
authors.affiliation: Department of Nutrition and Food Science, Faculty of Biology, University of Barcelona, Av. Diagonal 645, 08028 Barcelona, Spain.
authors.forename: Maria
authors.initials: M
authors.lastname: del Mar Grasa
authors.forename: Marta
authors.initials: M
authors.lastname: Serrano
authors.forename: José Antonio
authors.initials: JA
authors.lastname: Fernández-López
authors.forename: Marià
authors.initials: M
authors.lastname: Alemany
mesh_terms: D000315:Adrenalectomy; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D019440:Anti-Obesity Agents / Q000494:pharmacology*; D001786:Blood Glucose / Q000187:drug effects; D001823:Body Composition / Q000187:drug effects; D003345:Corticosterone / Q000494:pharmacology*; D004347:Drug Interactions; D004734:Energy Metabolism / Q000187:drug effects*; D004970:Estrone / Q000031:analogs & derivatives* / Q000494:pharmacology; D005260:Female; D050356:Lipid Metabolism / Q000187:drug effects*; D009829:Oleic Acids / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000893:Anti-Inflammatory Agents; D019440:Anti-Obesity Agents; D001786:Blood Glucose; D009829:Oleic Acids; D004970:Estrone; C108709:oleoyl-estrone; D003345:Corticosterone