The plasma concentration of advanced oxidation protein products and arterial stiffness in apparently healthy adults.
BACKGROUND
Oxidative stress plays an important role in the pathogenesis of atherosclerosis. Advanced oxidation protein products (AOPP) are markers of oxidative stress and mediators of inflammation. Increased arterial stiffness is associated with increased risk of cardiovascular mortality and morbidity. The aim of this study was to evaluate the relationship between an indirect marker of arterial stiffness and the AOPP level in apparently healthy individuals.


RESULTS
Arterial stiffness was estimated with the use of the stiffness index (SI(DVP)) which significantly correlated with age, mean blood pressure, body fat content and AOPP. The SI(DVP) was associated with AOPP concentration in both single (R = 0.22, p = 0.03) and multiple regression models adjusted for age, sex, mean blood pressure and body fat content (R(2) = 42%, p < 0.0001).


CONCLUSIONS
The AOPP concentration is elevated in healthy people with increased values of stiffness index. This finding supports the concept that oxidative stress may contribute to arterial stiffening in humans.
Wykretowicz
Andrzej
A
Division of Cardiology-Intensive Therapy, Department of Internal Medicine, University School of Medicine, Poznan, Poland. awykreto@ptkardio.pl
Adamska
Karolina
K
Krauze
Tomasz
T
Guzik
Przemyslaw
P
Szczepanik
Adam
A
Rutkowska
Agnieszka
A
Wysoki
Henryk
H
D000273:Adipose Tissue; D000328:Adult; D015415:Biomarkers / Q000378:metabolism*; D001794:Blood Pressure; D001798:Blood Proteins / Q000737:chemistry / Q000378:metabolism*; D015992:Body Mass Index; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D014655:Vascular Resistance / Q000502:physiology*
D015415:Biomarkers; D001798:Blood Proteins