Regional cerebral blood flow after recovery from anorexia or bulimia nervosa.
OBJECTIVE
Abnormalities of regional cerebral blood flow (rCBF) have been found in individuals who are ill with anorexia (AN) or bulimia nervosa (BN). Little is known about whether rCBF normalizes after recovery from AN and BN.


METHODS
Eighteen control women (CW), 10 recovered restricting type AN, 8 recovered AN with a binging history, and 9 recovered BN participants without a history of AN were studied using positron emission tomography and [(15)O]water in order to assess rCBF.


RESULTS
Partial volume corrected rCBF values in cortical and subcortical brain regions were similar between groups. Neither current body mass index nor age correlated with rCBF values.


CONCLUSIONS
The results from this study indicate that rCBF normalizes with long-term recovery. Thus, altered rCBF is unlikely to confound functional imaging studies in AN or BN after recovery.
Frank
Guido K
GK
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA.
Bailer
Ursula F
UF
Meltzer
Carolyn C
CC
Price
Julie C
JC
Mathis
Chester A
CA
Wagner
Angela
A
Becker
Carl
C
Kaye
Walter H
WH
D000328:Adult; D000855:Anorexia / Q000503:physiopathology* / Q000628:therapy*; D015992:Body Mass Index; D001921:Brain / Q000033:anatomy & histology / Q000098:blood supply* / Q000503:physiopathology*; D052018:Bulimia Nervosa / Q000503:physiopathology* / Q000628:therapy*; D002560:Cerebrovascular Circulation / Q000502:physiology; D006801:Humans; D008279:Magnetic Resonance Imaging; D049268:Positron-Emission Tomography; D020127:Recovery of Function