Lack of susceptibility to ischemic necrosis of the remnant liver following partial hepatectomy in the rat.
OBJECTIVE
The increase in liver lobule dimensions that occurs following partial hepatectomy could predispose living related donors to ischemic hepatic injury were shock-like states to occur in the future.


METHODS
In the present study, rats that had undergone 70% partial hepatectomies or sham surgery six weeks earlier were progressively bled to a maximum of 40% total circulating blood volume.


RESULTS
Despite significant increases in liver lobule dimensions (1.5x controls), hepatectomized rats did not manifest biochemical or histologic evidence of early or more extensive hepatic injury when compared to sham-operated controls.


CONCLUSIONS
The results of this study suggest that despite theoretical concerns, living related donors are not predisposed to develop ischemic hepatic injury were shock-like states to develop in the future.
Watt
K
K
Section of Hepatology, Department of Medicine, University of Manitoba Winnipeg, Manitoba, Canada.
Kives
K
K
Corbin
I
I
Zhang
M
M
Minuk
G Y
GY
D000818:Animals; D006498:Hepatectomy; D007511:Ischemia / Q000473:pathology*; D008099:Liver / Q000098:blood supply* / Q000473:pathology; D008115:Liver Regeneration / Q000502:physiology; D016031:Liver Transplantation / Q000473:pathology; D019520:Living Donors; D009336:Necrosis; D051381:Rats; D017207:Rats, Sprague-Dawley; D012769:Shock / Q000473:pathology; D020858:Tissue and Organ Harvesting