title: Reduced cortical surface area in multiple sclerosis.
abstract: OBJECTIVE
  To assess utility of cortical surface area as a measure of disease progression in multiple sclerosis (MS).
  
  
  METHODS
  We measured two-dimensional flattened cortical surface area on high-resolution magnetic resonance imaging (MRI) scans obtained in 15 subjects with clinically definite MS and ten normal subjects.
  
  
  CONCLUSIONS
  Single hemisphere cortical area was reduced in MS patients compared with controls (96,451 versus 71,710 mm(2)). We found no significant relationship of cortical surface area to disability or disease duration. T2 lesion load was negatively correlated with two-dimensional cortical surface area (r=-0.62).
  
  
  CONCLUSIONS
  Cortical surface area is decreased in MS and may be a useful measure of disease progression.
authors.affiliation: Department of Neurology and Rehabilitation, University of Illinois at Chicago, Chicago, IL 60612, USA. dhier@uic.edu
authors.forename: Daniel B
authors.initials: DB
authors.lastname: Hier
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
mesh_terms: D000328:Adult; D002540:Cerebral Cortex / Q000473:pathology*; D007839:Functional Laterality; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000473:pathology*