title: Nonirradiated versus irradiated Achilles allograft: in vivo failure comparison.
abstract: BACKGROUND
  Many studies suggest that gamma irradiation decreases allograft strength in a dose-dependent manner. No study has demonstrated that this decrease in strength translates into higher clinical failures.
  
  
  OBJECTIVE
  Irradiation of allograft tissue will lead to higher early clinical failure in anterior cruciate ligament (ACL) reconstruction.
  
  
  METHODS
  Cohort study; Level of evidence, 3.
  
  
  METHODS
  Medical records were reviewed for 90 consecutive patients who had received Achilles allograft reconstruction for unilateral primary ACL injuries at one institution between July 2001 and June 2002. One half of patients received nonirradiated Achilles allograft and the other half received irradiated Achilles allograft at a dose range of 2.0 to 2.5 Mrad. The ACL allograft reconstructions were performed using the same surgical technique. The rehabilitation program was identical for both groups. All clinical failures were recorded.
  
  
  RESULTS
  At least 6 months' follow-up was available on 42 subjects in the nonirradiated group and 33 subjects in the irradiated group. A significant difference was noted in early failure rates between the groups (P <.01). The nonirradiated group had 1 in 42 (2.4%) catastrophic failure. In the irradiated group, 11 of 33 (33%) Achilles tendon grafts failed.
  
  
  CONCLUSIONS
  Less than satisfactory results led the senior authors to discontinue the use of irradiated allografts in ACL surgery. Continued research into alternatives to gamma irradiation is needed.
authors.affiliation: Department of Orthopaedics and Rehabilitation, University of Florida, Gainesville, Florida, USA. mattrappe@hotmail.com
authors.forename: Matthew
authors.initials: M
authors.lastname: Rappé
authors.forename: MaryBeth
authors.initials: M
authors.lastname: Horodyski
authors.forename: Keith
authors.initials: K
authors.lastname: Meister
authors.forename: Peter A
authors.initials: PA
authors.lastname: Indelicato
mesh_terms: D000125:Achilles Tendon / Q000528:radiation effects* / Q000637:transplantation*; D000293:Adolescent; D000328:Adult; D016118:Anterior Cruciate Ligament / Q000601:surgery*; D015331:Cohort Studies; D004307:Dose-Response Relationship, Radiation; D005500:Follow-Up Studies; D005720:Gamma Rays; D006801:Humans; D008875:Middle Aged; D012016:Reference Values; D014184:Transplantation, Homologous; D017211:Treatment Failure