title: Multiple complications due to osteoradionecrosis in a patient with thromboangiitis obliterans.
abstract: A case is presented of a patient with thromboangiitis obliterans (TAO) who developed severe necrosis of the intraoral soft tissues and maxillary and mandibular bone after radiotherapy for a cT2N0M0 squamous cell carcinoma of the soft palate. Multiple surgical procedures including partial resection of the mandible and maxilla and reconstruction of intraoral and extraoral defects with a pectoralis major myocutaneous flap and anterolateral thigh flap were performed with partial success. Although a causal relationship between TAO and the described complications cannot be verified, close monitoring of patients with TAO who are being treated with radiotherapy is advised.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
authors.forename: Richard
authors.initials: R
authors.lastname: Barkhuysen
authors.forename: Geert O R J
authors.initials: GO
authors.lastname: Janssens
authors.forename: Peter C M
authors.initials: PC
authors.lastname: de Wilde
authors.forename: Matthias A W
authors.initials: MA
authors.lastname: Merkx
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy*; D019583:Dose Fractionation, Radiation; D005260:Female; D006801:Humans; D008439:Maxillary Diseases / Q000209:etiology* / Q000601:surgery; D008875:Middle Aged; D010025:Osteoradionecrosis / Q000209:etiology* / Q000601:surgery; D010157:Palatal Neoplasms / Q000532:radiotherapy*; D010160:Palate, Soft; D013280:Stomatitis / Q000209:etiology / Q000601:surgery; D013524:Surgical Flaps; D013919:Thromboangiitis Obliterans / Q000150:complications*