title: A general and efficient five-step one-pot procedure leading to nitrogen-bridgehead heterocycles containing an imidazole ring.
abstract: A very simple annulation reaction was designed, allowing an imidazole moiety to be fused onto a range of pyridine-based derivatives. The methodology consists of an activation step via the formation of a pyridinium salt to increase the electrophilicity of the pyridine ring, followed by a cascade reaction triggered by a nucleophilic attack of the iminium moiety. Depending on the pyridinium salt, it is possible to obtain functionalized imidazole moieties.
authors.affiliation: Chemistry Department, WestCHEM, University of Glasgow, Glasgow, United Kingdom.
authors.forename: Alexis D C
authors.initials: AD
authors.lastname: Parenty
authors.forename: Yu-Fei
authors.initials: YF
authors.lastname: Song
authors.forename: Craig J
authors.initials: CJ
authors.lastname: Richmond
authors.forename: Leroy
authors.initials: L
authors.lastname: Cronin
mesh_terms: D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry*; D007093:Imidazoles / Q000737:chemistry*; D015394:Molecular Structure; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D006571:Heterocyclic Compounds; D007093:Imidazoles; D011725:Pyridines