[Morphological correlate of newborns peripheral blood cells with activity of maternal cytomegalovirus infection].
Peripheral blood cells specimens were analyzed electron microscopically in 14 newborns with congenital CMV infection (I group) and in 11 newborns with sub clinical form of CMV infection (II group) to correlate the ultra structural features of the neonates' blood cells with the maternal CMV activity in active primary and reactivated latent CMV infection forms. Control - 20 healthy newborns. The groups were arranged according the data of immune testing on IgM and IgG antibodies using ELIZA method. Criteria for cases were: 1) neonatal death and 2) severe respiratory distress or central nervous system-related symptoms at birth. In group I ultra structural findings of basophiles and lymphocytes indicate on severe damages of cells related to high risk (35%) of vertical transmission of CMV infection by placenta. In group II with relative less risk of the vertical transmission (20%) in latent reactivated CMV infection in blood cells, especially, lymphocytes, the structural changes such apoptosis and necrosis were found. The data obtained suggest the presence of significant premorbid background with subclinical course of CMV infection and structural damages of blood cells in newborns.
Pkhakadze
I Dzh
ID
Gogiashvili
L E
LE
Tsagareli
Z G
ZG
D001491:Basophils / Q000502:physiology*; D003586:Cytomegalovirus Infections / Q000276:immunology* / Q000503:physiopathology*; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D007075:Immunoglobulin M / Q000276:immunology*; D007231:Infant, Newborn; D007962:Leukocytes / Q000502:physiology*; D009035:Mothers
D007074:Immunoglobulin G; D007075:Immunoglobulin M