Chemoenzymatic synthesis and antimicrobial activity evaluation of monogalactosyl diglycerides.
Monogalactosyl diglycerides with medium to long fatty acid acyl chains, were prepared and examined for antimicrobial activity against Gram positive, Gram negative bacteria and fungi. The study of their in vitro antimicrobial activity confirms the significant activity of some monogalactosyl diacylglycerol analogues and establishes for the galactose series that the 1,2-disubstitution and the octanoyl chain are the proper structural features for the maximum activity.
Cateni
Francesca
F
Department of Pharmaceutical Sciences, University of Trieste, P.zle Europa, 1, 34127 Trieste, TS, Italy. cateni@univ.trieste.it
Bonivento
Paolo
P
Procida
Giuseppe
G
Zacchigna
Marina
M
Favretto
Luciana Gabrielli
LG
Scialino
Giuditta
G
Banfi
Elena
E
D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D004075:Diglycerides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D005658:Fungi / Q000187:drug effects; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests
D000890:Anti-Infective Agents; D004075:Diglycerides