Estimating the infectivity of CCR5-tropic simian immunodeficiency virus SIV(mac251) in the gut.
CD4+ T-cell depletion during acute human immunodeficiency virus infection occurs predominantly in the gastrointestinal mucosa. Using experimental data on SIV(mac251) viral load in blood and CD4+ T cells in the jejunum, we modeled the kinetics of CD4+ T-cell infection and death and estimated the viral infectivity. The infectivity of SIV(mac251) is higher than previously estimated for SHIV89.6P infection, but this higher infectivity is offset by a lower average peak viral load in SIV(mac251). Thus, the dynamics of target cell infection and death are remarkably similar between a CXCR4- and a CCR5-tropic infection in vivo.
Wilson
David P
DP
Department of Haematology, Prince of Wales Hospital, University of New South Wales, Kensington, New South Wales, Australia.
Mattapallil
Joseph J
JJ
Lay
Matthew D H
MD
Zhang
Lei
L
Roederer
Mario
M
Davenport
Miles P
MP
D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D041981:Gastrointestinal Tract / Q000821:virology*; D006801:Humans; D008253:Macaca mulatta; D008433:Mathematics; D008962:Models, Theoretical; D019713:Receptors, CCR5 / Q000276:immunology*; D016097:Simian Acquired Immunodeficiency Syndrome; D015302:Simian Immunodeficiency Virus / Q000378:metabolism / Q000472:pathogenicity*; D019562:Viral Load
D019713:Receptors, CCR5