Abyssomicin E, a highly functionalized polycyclic metabolite from Streptomyces species.
Abyssomicin E (1), a new polycyclic metabolite with a C19 skeleton, was isolated from Streptomyces sp. (HKI0381). Its chemical structure was determined by comprehensive NMR and MS spectroscopic analyses. For the first time in this recently discovered class of compounds, the absolute stereochemistry was directly established by subsequent single-crystal X-ray diffraction study using anomalous dispersion with copper radiation.
Niu
Xue-Mei
XM
Leibniz-Institute for Natural Product Research and Infection Biology, Hans-Knöll-Institute, Beutenbergstrasse 11a, D-07745 Jena, Germany.
Li
Sheng-Hong
SH
Görls
Helmar
H
Schollmeyer
Dieter
D
Hilliger
Matthias
M
Grabley
Susanne
S
Sattler
Isabel
I
D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism*; D008958:Models, Molecular; D015394:Molecular Structure; D013302:Streptomyces / Q000737:chemistry* / Q000145:classification / Q000378:metabolism*
D019086:Bridged Bicyclo Compounds, Heterocyclic; C522223:abyssomicin E