title: Epidermodysplasia verruciformis occurring in a patient with human immunodeficiency virus: a case report.
abstract: Epidermodysplasia verruciformis (EV) is an uncommon dermatosis associated with human papillomavirus (HPV) infection in association with defects in cell-mediated immunity. Malignant transformation to squamous cell carcinoma has been associated with lesions caused by HPV-5, HPV-8, and HPV-14. Clinically, the disease may be confused with verruca plana, seborrheic keratosis, and pityriasis versicolor. We present an unusual case of EV occurring in a human immunodeficiency virus (HIV)-positive man and discuss the clinical and histologic findings. Clinically, the patient had 1- to 3-mm hypopigmented smooth macules covering the entire body. Histopathologic examination of the skin biopsy results demonstrated enlarged keratinocytes with prominent blue-gray cytoplasm and clumping of keratohyalin granules within the granular layer of the epidermis. Although EV typically is viewed as a disease of childhood, sometimes presenting in patients with a family history of the disease, it rarely may be seen in immunocompromised adults.
authors.affiliation: Department of Internal Medicine, Section of Dermatology, University of Nebraska Medical Center, Omaha, NE 68198-3135, USA.
authors.forename: Tricia L
authors.initials: TL
authors.lastname: Hultgren
authors.forename: Shashi K
authors.initials: SK
authors.lastname: Srinivasan
authors.forename: Dominick J M
authors.initials: DJ
authors.lastname: DiMaio
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D044383:Black People; D004819:Epidermodysplasia Verruciformis / Q000150:complications* / Q000276:immunology / Q000473:pathology / Q000628:therapy; D006801:Humans; D008297:Male; D030361:Papillomavirus Infections / Q000150:complications; D012880:Skin Pigmentation