title: Acute myeloid leukaemia secondary to treatment with capecitabine for metastatic colorectal cancer.
abstract: A 63-year-old woman was diagnosed with acute myelo-monocytic leukaemia, associated with MLL gene rearrangement, 16 months after completion of oral capecitabine for metastatic colon cancer. Capecitabine, recommended for use in metastatic breast and colon cancer and more recently as adjuvant treatment of colon cancer, has not previously been reported to be associated with secondary cancer.
authors.affiliation: Department of Haematology, West Middlesex University Hospital, Middlesex, UK.
authors.forename: Susan
authors.initials: S
authors.lastname: Shapiro
authors.forename: George
authors.initials: G
authors.lastname: Hughes
authors.forename: Magda Jabbar
authors.initials: MJ
authors.lastname: Al-Obaidi
authors.forename: Eamon
authors.initials: E
authors.lastname: O'Reilly
authors.forename: Subramanian
authors.initials: S
authors.lastname: Ramesh
authors.forename: Jason
authors.initials: J
authors.lastname: Smith
authors.forename: Riz
authors.initials: R
authors.lastname: Ahmad
authors.forename: Charlotte
authors.initials: C
authors.lastname: Dawson
authors.forename: Pippa
authors.initials: P
authors.lastname: Riddle
authors.forename: Mallika
authors.initials: M
authors.lastname: Sekhar
mesh_terms: D000208:Acute Disease; D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects*; D000069287:Capecitabine; D015179:Colorectal Neoplasms / Q000556:secondary*; D003841:Deoxycytidine / Q000009:adverse effects / Q000031:analogs & derivatives*; D005472:Fluorouracil / Q000009:adverse effects / Q000031:analogs & derivatives*; D006801:Humans; D007951:Leukemia, Myeloid / Q000139:chemically induced / Q000473:pathology*
chemical_list: D000964:Antimetabolites, Antineoplastic; D003841:Deoxycytidine; D000069287:Capecitabine; D005472:Fluorouracil