[Factors affecting posttransfusion platelet efficiency "close relationship between patient and product"].
A great variety of patient- and product-related factors influence the outcome of platelet transfusions. The patient-related factors are numerous, either physical factors as weight and height, or related to pathological being as splenomegaly, fever, infection, disseminated intravascular coagulation, previous HLA allo-immunization, or related to the treatment, as amphotericin. Major platelet factors that are associated with impaired responses are giving a decreased dose of platelets, ABO incompatible products, and platelets stored for more than 48 hours. When trying to prevent or to treat refractoriness and to finely tune platelet transfusions, all these factors have to be taken into account, and a good coordination between the blood bank and the clinician team is essential.
Sensebé
Luc
L
Service recherche EFS Centre-Atlantique, 2 boulevard Tonnellé, BP 52009, 37020 Tours cedex 1, France. luc.sensebe@efs.sante.fr
D000017:ABO Blood-Group System; D001792:Blood Platelets / Q000502:physiology*; D006680:HLA Antigens; D006801:Humans; D017713:Platelet Transfusion / Q000379:methods*; D016896:Treatment Outcome
D000017:ABO Blood-Group System; D006680:HLA Antigens