title: Reversal of salicylate-induced euglycemic delirium with dextrose.
abstract: Salicylate poisoning inhibits Krebs cycle enzymes and uncouples oxidative phosphorylation. Under these circumstances, we hypothesize that CNS glucose supply is sometimes unable to keep up with demand resulting in hypoglycorrhacia and delirium even in the face of serum euglycemia. Supporting this conjecture, we report two euglycemic patients with salicylate-induced delirium who responded to boluses of concentrated dextrose with a prompt improvement in mental status.
authors.affiliation: Department of Emergency Medicine and Anesthesia, University of British Columbia, Vancouver, British Columbia, Canada. nickkuzak@hotmail.com
authors.forename: Nick
authors.initials: N
authors.lastname: Kuzak
authors.forename: Jeff R
authors.initials: JR
authors.lastname: Brubacher
authors.forename: James R
authors.initials: JR
authors.lastname: Kennedy
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D003693:Delirium / Q000097:blood / Q000188:drug therapy*; D005260:Female; D005947:Glucose / Q000627:therapeutic use*; D006801:Humans; D008875:Middle Aged; D012459:Salicylates / Q000097:blood / Q000506:poisoning*
chemical_list: D001786:Blood Glucose; D012459:Salicylates; D005947:Glucose