Correlations between carotid IMT, factor VIII activity level and metabolic disturbances: a cardio-vascular risk factor in the HIV positive persons.
In the HIV infection, the short time-scale between the HIV-induced cardiovascular events and the onset of antiretroviral therapy elicits a thrombophilic co-factor that worsens the induced atherosclerosis. We compared the factor VIII plasma activity, previously implicated in arterial and venous thrombosis, with a surrogate marker of atherosclerosis, the carotid intima-media thickness, and with the usual atherosclerosis risk factors in 154 HIV infected outpatients. The FVIII plasma activity is significantly associated with the carotid intima-media thickness and, strongly, with blood glucose and triglycerides levels. A raised FVIII plasma activity is an important feature of the metabolic syndrome and a putative co-factor of HAART induced cardiovascular events. Thus the prevention of the HAART-induced cardio-vascular events should probably not be exclusively focused on atherosclerosis but likewise on the thrombus formation process.
de Saint Martin
Luc
L
Brest University Hospital, Brest, France. luc.desaintmartin@chu-brest.fr
Pasquier
Elisabeth
E
Vandhuick
Olivier
O
Arnaud
Bertrand
B
Vallet
Sophie
S
Duchemin
Jérôme
J
Bellein
Véronique
V
Bressollette
Luc
L
D000328:Adult; D019380:Anti-HIV Agents / Q000009:adverse effects; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects*; D015415:Biomarkers; D002318:Cardiovascular Diseases / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology*; D002339:Carotid Arteries / Q000000981:diagnostic imaging*; D005169:Factor VIII / Q000032:analysis*; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy; D039682:HIV-Associated Lipodystrophy Syndrome / Q000097:blood / Q000209:etiology; D006801:Humans; D008297:Male; D012307:Risk Factors; D014463:Ultrasonography
D019380:Anti-HIV Agents; D015415:Biomarkers; D005169:Factor VIII