[Preparation of nano-liposome enveloping Flos Magnoliae volatile oil].
OBJECTIVE
To discuss the influences of the concentrations of sodium cholate, cholesterol and drug, preparation temperature, ultrasonic time and power on the particle size and encapsulation efficiency of Flos Magnoliae volatile oil nano-liposome through film-ultrasonic wave technique together with membrane filter method.


METHODS
The nano-liposomes were prepared by film-ultrasonic wave technique together with membrane filter method. The drug content in liposomes was determined by gas chromatography and the particle size was determined by laser light scattering granularity equipment.


RESULTS
By film-ultrasonic wave technique together with membrane filter method, the liposomes in the range of 30-40 nm were prepared. The prepared nano-liposomes demonstrated good decentralization and homogeneity, and the encapsulation efficiency was (91.7+/-3)%.


CONCLUSIONS
Film-ultrasonic wave together with membrane filter method is a simple method to fabricate nano-magnoliae liposome.
Wu
Min
M
Department of Traditional Chinese Medicine, Xinhua Hospital, Medical School, Shanghai Jiaotong University, Shanghai 200092, China. xinhuayiyuan123@126.com
Liu
Juan
J
Zhang
Xin
X
D004339:Drug Compounding / Q000379:methods; D035264:Flowers / Q000737:chemistry; D006801:Humans; D008081:Liposomes / Q000737:chemistry*; D031566:Magnolia / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D009822:Oils, Volatile / Q000737:chemistry*; D004364:Pharmaceutical Preparations / Q000737:chemistry; D010938:Plant Oils / Q000737:chemistry
D008081:Liposomes; D009822:Oils, Volatile; D004364:Pharmaceutical Preparations; D010938:Plant Oils