title: [Clinical efficacy of sildenafil in patients with pulmonary hypertension in functional class II or III].
abstract: OBJECTIVE
  To assess the efficacy of treatment with sildenafil monotherapy in patients with pulmonary hypertension.
  
  
  METHODS
  An observational study was undertaken in 11 patients with pulmonary hypertension in functional class II or III who received treatment with sildenafil (150 mg/day). Seven of the patients had inoperable chronic thromboembolic pulmonary hypertension and 4 had pulmonary arterial hypertension. To assess treatment response, the following parameters were assessed during follow-up at 3, 6, and 12 months: exercise tolerance in the 6-minute walk test, change in functional class, and systolic pulmonary arterial pressure measured by echocardiography.
  
  
  RESULTS
  We observed a significant improvement in exercise tolerance, as shown by increased 6-minute walk distance after 3, 6, and 12 months of treatment (increases of 20, 67, and 95 m, respectively). All patients showed an improvement in functional class. The results of echocardiography did not reveal statistically significant differences in systolic pulmonary arterial pressure between baseline and 6 or 12 months of treatment. No significant adverse effects were observed, although sildenafil treatment was suspended in 1 patient due to persistent headache.
  
  
  CONCLUSIONS
  The results of this study confirm that sildenafil is an effective drug for the management of pulmonary arterial hypertension and inoperable chronic thromboembolic pulmonary hypertension both in the short term and medium to long term, and that the drug is well tolerated and shows few side effects.
authors.affiliation: Servicio de Neumología, Complexo Hospitalario Universitario Juan Canalejo, A Coruña, Spain. iotero@canalejo.org
authors.forename: Isabel
authors.initials: I
authors.lastname: Otero González
authors.forename: Marina
authors.initials: M
authors.lastname: Blanco Aparicio
authors.forename: Ana
authors.initials: A
authors.lastname: Souto Alonso
authors.forename: Inés
authors.initials: I
authors.lastname: Raposo Sonnenfeld
authors.forename: Héctor
authors.initials: H
authors.lastname: Verea Hernando
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000145:classification / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010879:Piperazines / Q000627:therapeutic use*; D011655:Pulmonary Embolism / Q000150:complications; D011687:Purines / Q000627:therapeutic use; D000068677:Sildenafil Citrate; D013450:Sulfones / Q000627:therapeutic use*; D014665:Vasodilator Agents / Q000627:therapeutic use*
chemical_list: D010879:Piperazines; D011687:Purines; D013450:Sulfones; D014665:Vasodilator Agents; D000068677:Sildenafil Citrate