[Air pollution and respiratory diseases: a central role for oxidative stress].
Epidemiological studies have clearly shown a relationship between respiratory diseases and air pollution. Ozone and ambient particles are the main pollutants contributing to the exacerbation of these pathologies. Their toxicity resides in their ability to generate an oxidative stress. The level of oxidative stress and the specificity of the cellular responses result from complex interactions between pro- and anti-oxidants, leading to differentiated cellular strategies. Hierarchical biological responses: adaptation, inflammation, lesions, can be determined according to the oxidative insult and individual anti-oxidant capacities. A better health risk assessment could be achieved by taking into account the oxidative properties of air pollution especially those of ultrafine particles.
Baeza
Armelle
A
Laboratoire de Cytophysiologie et Toxicologie Cellulaire, Université Paris, Denis-Diderot, Paris Cedex 05, France. baeza@univ-paris-diderot.fr
Marano
Francelyne
F
D000393:Air Pollutants / Q000633:toxicity; D000397:Air Pollution / Q000009:adverse effects*; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D018384:Oxidative Stress / Q000502:physiology*; D010126:Ozone / Q000009:adverse effects; D012140:Respiratory Tract Diseases / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology*
D000393:Air Pollutants; D010126:Ozone