The bradykinin type 2 receptor BE1 polymorphism and ethnicity influence systolic blood pressure and vascular resistance.
We examined the effect of -58 C/T and BE1 +9/-9 polymorphisms in the bradykinin B2 receptor gene on forearm vascular resistance (FVR) before and during intrabrachial artery infusion of the B2 receptor-, endothelium-dependent agonist bradykinin and the endothelium-independent agonist sodium nitroprusside in 228 normotensive subjects. In 166 white Americans, systolic blood pressure (SBP) and pulse pressure were highest in the BE1 +9/+9 group (118+/-2 and 51+/-2 mm Hg, respectively; P<0.05 versus -9/-9 for either), intermediate in the +9/-9 group (114+/-1 and 49+/-1 mm Hg, P<0.05 versus -9/-9 for pulse pressure), and lowest in the -9/-9 group (110+/-2 and 44+/-2 mm Hg). In 62 black Americans, FVR was 25% higher in the BE1 +9/+9 group compared with the BE1 +9/-9 and -9/-9 groups at baseline (P=0.038) or during bradykinin (P=0.03). Increased SBP or vascular resistance may contribute to increased left ventricular mass reported previously in individuals with the BE1+9/+9 genotype.
Pretorius
M M
MM
Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Gainer
J V
JV
Van Guilder
G P
GP
Coelho
E B
EB
Luther
J M
JM
Fong
P
P
Rosenbaum
D D
DD
Malave
H A
HA
Yu
C
C
Ritchie
M D
MD
Vaughan
D E
DE
Brown
N J
NJ
D000328:Adult; D001741:Black or African American / Q000235:genetics*; D001783:Blood Flow Velocity / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects / Q000235:genetics*; D001920:Bradykinin / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D005260:Female; D005542:Forearm / Q000098:blood supply*; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007261:Infusions, Intra-Arterial; D008297:Male; D009599:Nitroprusside / Q000008:administration & dosage; D010641:Phenotype; D011110:Polymorphism, Genetic; D043782:Receptor, Bradykinin B2 / Q000819:agonists / Q000235:genetics*; D012039:Regional Blood Flow / Q000235:genetics; D014655:Vascular Resistance / Q000187:drug effects / Q000235:genetics*; D014665:Vasodilator Agents / Q000008:administration & dosage; D044465:White People / Q000235:genetics*
D043782:Receptor, Bradykinin B2; D014665:Vasodilator Agents; D009599:Nitroprusside; D001920:Bradykinin