Synthesis and biodistribution of 8-iodo-11-(4-methylpiperazino)-5H-dibenzo[b,e][1,4]-diazepine: Iozapine.
8-Iodo-11-(4-methylpiperazino)-5H-dibenzo[b,e][1,4]-diazepine: Iozapine, a potential D(4)-receptor ligand was synthesized using oxidative iodo-destannylation reaction. The preliminary biodistribution studies of radioiodinated iozapine have shown that the compound is taken up in the brains of mice and rabbits.
Joshua
Alummoottil V
AV
Department of Oncology, University of Alberta, 11560 University Avenue, Edmonton, Alberta, Canada T6G 1Z2. alummott@cancerboard.ab.ca
Sharma
Sanjay K
SK
Strelkov
Alicia
A
Scott
John R
JR
Martin-Iverson
Mathew T
MT
Abrams
Douglas N
DN
Silverstone
Peter H
PH
McEwan
Alexander J B
AJ
D000818:Animals; D001921:Brain / Q000378:metabolism*; D003024:Clozapine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000378:metabolism / Q000493:pharmacokinetics; D051379:Mice; D011817:Rabbits; D050638:Receptors, Dopamine D4 / Q000378:metabolism; D014018:Tissue Distribution
C522904:iozapine; D050638:Receptors, Dopamine D4; D003024:Clozapine