title: Administering a glyceryl trinitrate infusion: big is not always best.
abstract: With the use of some simple calculations it can be demonstrated that the choice of cannula and initial glyceryl trinitrate (GTN) infusion rate for patients with acute left ventricular failure (LVF) requires some careful thought. If a GTN infusion is commenced at a rate of 1 ml/h, a critically unwell patient with a large cannula--for example, a grey cannula--will have to wait over 6 min for the drug to enter the body. This compares with 1.5 min for a pink cannula at the same infusion rate. If a large-diameter cannula is chosen for these patients, then a fast initial infusion rate should also be chosen to ensure that the GTN begins to act quickly. The rate can later be adjusted depending on clinical conditions.
authors.affiliation: Department of Emergency Medicine, Royal Infirmary of Edinburgh, 51 Little France Crescent, Edinburgh EH16 4SA, UK. mattreed1@hotmail.com
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Reed
mesh_terms: D004305:Dose-Response Relationship, Drug; D006801:Humans; D007262:Infusions, Intravenous / Q000295:instrumentation / Q000379:methods; D005996:Nitroglycerin / Q000008:administration & dosage*; D016896:Treatment Outcome; D014665:Vasodilator Agents / Q000008:administration & dosage*; D018487:Ventricular Dysfunction, Left / Q000188:drug therapy*
chemical_list: D014665:Vasodilator Agents; D005996:Nitroglycerin