[Laryngopharyngeal reflux].
Laryngopharyngeal reflux (LPR) or reflux laryngitis refers to the backflow of stomach contents into the larynx and hypopharynx. LPR is increasingly cited as the cause of laryngeal signs and symptoms such as globus sensation, hoarseness, chronic cough, chronic throat clearing, and throat pain. The diagnosis of LPR is often based on the presenting symptoms and associated laryngeal signs. An empiric trial of double-dose proton pump inhibitors (PPIs) has been recommended as a first line therapy in patients with suspected LPR. However, recent systemic review has shown no benefit of PPIs over placebo in the treatment of LPR. Clearly, more well designed, prospective large scale trials are warranted in the future.
Takeda
Hiroshi
H
Department of Gastroenterolgy and Hematology, Hokkaido University Graduate School of Medicine.
Oridate
Nobuhiko
N
Shimizu
Yuichi
Y
Kato
Mototsugu
M
Asaka
Masahiro
M
Fukuda
Satoshi
S
Yamamoto
Junji
J
D004791:Enzyme Inhibitors / Q000627:therapeutic use; D050782:Esophageal pH Monitoring; D005764:Gastroesophageal Reflux / Q000175:diagnosis / Q000503:physiopathology* / Q000628:therapy; D006801:Humans; D007818:Laryngeal Diseases / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D007828:Laryngoscopy; D010608:Pharyngeal Diseases / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D054328:Proton Pump Inhibitors
D004791:Enzyme Inhibitors; D054328:Proton Pump Inhibitors