Analytical interferences of drugs in the chemical examination of urinary protein.
OBJECTIVE
To evaluate the potential analytical interference of 24 drugs in the urinary protein.


METHODS
The analysis was done using Multistix 10SG and comparing the results of controls with urine samples supplemented with drugs.


RESULTS
Positive interferences occurred with ciprofloxacin, quinine and chloroquine in supratherapeutical concentrations, while chloroquine interfered also in therapeutical concentration.


CONCLUSIONS
False proteinuria in test-strips can lead to erroneous interpretations with repercussion in clinical procedures and higher costs to the health system.
Scotti da Silva-Colombeli
Adriana
A
Laboratório de Análises Clínicas, Hospital Universitário, Universidade Federal de Santa Catarina, Campus Universitário Trindade, 88.040-970 Florianópolis, Santa Catarina, Brazil.
Falkenberg
Miriam
M
D002738:Chloroquine / Q000032:analysis; D002939:Ciprofloxacin / Q000032:analysis; D019411:Clinical Laboratory Techniques / Q000295:instrumentation / Q000379:methods; D006801:Humans; D004364:Pharmaceutical Preparations / Q000032:analysis*; D011507:Proteinuria / Q000175:diagnosis* / Q000652:urine*; D011803:Quinine / Q000032:analysis; D011934:Reagent Strips; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
D004364:Pharmaceutical Preparations; D011934:Reagent Strips; D002939:Ciprofloxacin; D002738:Chloroquine; D011803:Quinine