Carbamate prodrugs of N-alkylfuramidines.
The synthesis and evaluation of 2,5-bis[4-(N-ethoxycarbonyl-N'-isopropyl)amidinophenyl]furan, 2,5-bis[4-(N-2,2,2-trichloroethoxycarbonyl-N'-isopropyl)amidinophenyl]furan and 2,5-bis[4-(N-cyclopentyl-N'-2,2,2-trichloroethoxycarbonyl)amidinophenyl]furan as prodrugs of bis-N-alkylamidines are reported. The results show that the bis-2,2,2-trichloroethyl carbamates function effectively in a rat model for Pneumocystis pneumonia.
Rahmathullah
Syed M
SM
Department of Chemistry, Georgia State University, University Plaza, Atlanta, GA 30303-3082, United States.
Tidwell
Richard R
RR
Jones
Susan K
SK
Hall
James E
JE
Boykin
David W
DW
D000818:Animals; D001550:Benzamidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D002219:Carbamates / Q000737:chemistry*; D003560:Cysts / Q000188:drug therapy; D004195:Disease Models, Animal; D005663:Furans / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D008168:Lung / Q000187:drug effects / Q000473:pathology; D045363:Pneumocystis carinii / Q000187:drug effects; D011020:Pneumonia, Pneumocystis / Q000188:drug therapy / Q000382:microbiology; D011355:Prodrugs / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats
D001550:Benzamidines; D002219:Carbamates; D005663:Furans; D011355:Prodrugs; C033286:furamidine