title: Cholesteryl ester transfer protein B1B1 genotype as a predictor of coronary artery disease in Taiwanese with type 2 diabetes mellitus.
abstract: Diabetes is known to be a high-risk factor for coronary artery disease (CAD), and lipid abnormalities have been found to possibly contribute to CAD in diabetic patients. Cholesteryl ester transfer protein (CETP) gene TaqIB polymorphism is associated with lipid profile variability, and this polymorphism may be a risk factor for CAD in diabetic patients. To clarify the relationship between CETP TaqIB gene polymorphism and CAD, we enrolled in our study 365 Taiwanese with type 2 diabetes mellitus (101 with CAD and 264 without CAD). The genotype of the subjects for TaqIB polymorphism of CETP in intron 1 was analyzed by using polymerase chain reaction-restriction fragment length polymorphism. The CETP B1B1 genotype (18.8% vs 8.5%, P = .002) and B1 allele (42.1% vs 29.7%, P = .002) were significantly more frequent in diabetic patients with CAD than those without CAD. Logistic regression analysis revealed that the CETP B1B1 genotype was associated with CAD in patients with type 2 diabetes mellitus (odds ratio, 3.18; 95% confidence interval, 1.54-6.54; P = .002). Interestingly, in diabetic patients, serum creatinine levels higher than 1.4 mg/dL were also associated with increased risk for CAD (odds ratio, 2.09; 95% confidence interval, 1.12-3.91; P = .02). Our results suggest that the CETP B1B1 genotype is a strong genetic predictor of CAD in Taiwanese with type 2 diabetes mellitus.
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan.
authors.forename: Ming-Chia
authors.initials: MC
authors.lastname: Hsieh
authors.forename: Kai-Jen
authors.initials: KJ
authors.lastname: Tien
authors.forename: Shun-Jen
authors.initials: SJ
authors.lastname: Chang
authors.forename: Chao-Sheng
authors.initials: CS
authors.lastname: Lo
authors.forename: Shih-Chieh
authors.initials: SC
authors.lastname: Hsin
authors.forename: Jeng-Yueh
authors.initials: JY
authors.lastname: Hsiao
authors.forename: Shih-Chieh
authors.initials: SC
authors.lastname: Hsu
authors.forename: Hui-Ting
authors.initials: HT
authors.lastname: Liang
authors.forename: Hung-Chun
authors.initials: HC
authors.lastname: Chen
authors.forename: Shyi-Jang
authors.initials: SJ
authors.lastname: Shin
authors.forename: Shiu-Ru
authors.initials: SR
authors.lastname: Lin
mesh_terms: D000328:Adult; D000368:Aged; D053480:Cholesterol Ester Transfer Proteins / Q000235:genetics*; D008076:Cholesterol, HDL / Q000097:blood; D003324:Coronary Artery Disease / Q000209:etiology / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged
chemical_list: D053480:Cholesterol Ester Transfer Proteins; D008076:Cholesterol, HDL