title: [Pharmacological properties of phosphorylacetohydrazides in experimental myocardial ischemia].
abstract: It is shown that 2-chloroethoxy-para-N-dimethylphosphorylacetohydrazide and N-acethylhydrazide-para-dimethylaminophenyl-2-chloroethoxyphosphorylacetic acid reliably reduce ischemia-induced depression of inotropic functions of the left ventricle in cats with experimental myocardial infarction model. The effect of both compounds can be explained by the maintenance of viability of the injured myocardium via a delay of the development of acidosis and the support of oxygen recycling in the ischemized zone. Both compounds show pronounced antiradical properties with a non-standard mechanism of action.
authors.forename: V P
authors.initials: VP
authors.lastname: Balashov
authors.forename: M I
authors.initials: MI
authors.lastname: Al'miasheva
authors.forename: R I
authors.initials: RI
authors.lastname: Tarasova
authors.forename: I F
authors.initials: IF
authors.lastname: Rusina
authors.forename: N P
authors.initials: NP
authors.lastname: Kul'kova
authors.forename: T V
authors.initials: TV
authors.lastname: Kurmysheva
authors.forename: O V
authors.initials: OV
authors.lastname: Voskresenskaia
mesh_terms: D000085:Acetates / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D002415:Cats; D004195:Disease Models, Animal; D006834:Hydrazines / Q000494:pharmacology* / Q000627:therapeutic use; D009200:Myocardial Contraction / Q000187:drug effects; D017202:Myocardial Ischemia / Q000188:drug therapy* / Q000503:physiopathology; D010101:Oxygen Consumption; D010756:Phosphoric Acids / Q000494:pharmacology*; D016277:Ventricular Function, Left / Q000187:drug effects
chemical_list: C115481:2-(chloroethoxy)-p-N-dimethylaminophenylphosphinylacetic acid hydrazide; D000085:Acetates; D006834:Hydrazines; D010756:Phosphoric Acids; C520798:p-dimethylaminophenyl-2-chloroethoxyphosphorylacetic acid N-acethylhydrazide