Lack of an effect of antibiotic treatment on prolonged detection of chlamydial DNA in murine genital tract infection.
Mice treated with antibiotics early or late after active infection had resolved were examined for chlamydial DNA in endocervical swabs. The early eradication of infection limited oviduct pathology, despite the continued detection of chlamydial DNA by nested PCR. Late antibiotic treatment had no effect on the ability to detect DNA or oviduct pathology.
Reeves
Dawn M
DM
Department of Pediatric Infectious Diseases and Microbiology and Immunology, Arkansas Children's Hospital and University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA.
Nagarajan
Uma
U
O'Connell
Catherine
C
Andrews
Charles W
CW
Darville
Toni
T
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002690:Chlamydia Infections / Q000188:drug therapy* / Q000209:etiology; D023502:Chlamydia muridarum / Q000187:drug effects*; D004271:DNA, Fungal / Q000032:analysis* / Q000235:genetics; D004318:Doxycycline / Q000494:pharmacology*; D005260:Female; D005831:Genital Diseases, Female / Q000188:drug therapy / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D021141:Nucleic Acid Amplification Techniques; D010957:Plasmids / Q000235:genetics; D016133:Polymerase Chain Reaction; D013997:Time Factors
D000900:Anti-Bacterial Agents; D004271:DNA, Fungal; D004318:Doxycycline