Phytochemical and antiprotozoal activity of Ocotea lancifolia.
Thirteen known isoquinoline alkaloids were isolated from Ocotea lancifolia, popularly known as << canela pilosa >> in Brasil and << laurel né >> by the Guarani people which means smell laurel. Their activities against the promastigote forms of three Leishmania strains and the bloodstream form of Trypanosoma cruzi were evaluated, as well as their hepatocytotoxicity. Among them, the noraporphine alkaloid (-) caaverine has shown the most interesting antiprotozoal activity against Leishmania and T. cruzi parasites.
Fournet
Alain
A
IRD, US 084, Laboratoire de Pharmacognosie, Faculté de Pharmacie, Université Paris-Sud, rue J.B. Clément, 92296 Châtenay-Malabry, France. alain.fournet@ird.fr
Ferreira
Maria Elena
ME
Rojas de Arias
Antonieta
A
Guy
Isabelle
I
Guinaudeau
Hélène
H
Heinzen
Horacio
H
D000818:Animals; D000981:Antiprotozoal Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D007891:Leishmania / Q000145:classification / Q000187:drug effects*; D027444:Ocotea; D021261:Parasitic Sensitivity Tests; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D014344:Trypanocidal Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D014349:Trypanosoma cruzi / Q000187:drug effects*
D000981:Antiprotozoal Agents; D010936:Plant Extracts; D014344:Trypanocidal Agents