title: An evaluation of the immunogenicity and safety of a new trivalent meningococcal polysaccharide vaccine.
abstract: The immunogenicity and safety of a meningococcal trivalent A/C/W135 polysaccharide vaccine was compared with that of a tetravalent A/C/Y/W135 polysaccharide vaccine in a randomised, double blind trial. The study included 360 adults, who received either a trivalent or tetravalent polysaccharide meningococcal vaccine. Antibody responses were determined by serum bactericidal antibody (rSBA) assays prior to vaccination and on day 28 and month 11 after vaccination. The percentage of participants in the trivalent vaccine group who had rSBA titres >or=8 on day 28 post-vaccination against serogroups A, C and W135 meningococci were 99, 98 and 91%, respectively. The corresponding figures in the tetravalent vaccine group were 99, 99 and 90%. The percentage of participants with various cut off levels of rSBA against serogroups A, W135 and C meningococci on day 28 and 11-month post-vaccination and the incidence of adverse events did not differ significantly between the two groups.
authors.affiliation: London School of Hygiene & Tropical Medicine, Keppel Street, London WC1E 7HT, UK. Daniel.chandramohan@lshtm.ac.uk
authors.forename: Daniel
authors.initials: D
authors.lastname: Chandramohan
authors.forename: Abraham
authors.initials: A
authors.lastname: Hodgson
authors.forename: Paul
authors.initials: P
authors.lastname: Coleman
authors.forename: Rita
authors.initials: R
authors.lastname: Baiden
authors.forename: Kwaku
authors.initials: K
authors.lastname: Asante
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Awine
authors.forename: Seth
authors.initials: S
authors.lastname: Owusu-Agyei
authors.forename: Dominique
authors.initials: D
authors.lastname: Boutriau
authors.forename: Christopher B
authors.initials: CB
authors.lastname: Nelson
authors.forename: Brain
authors.initials: B
authors.lastname: Greenwood
mesh_terms: D000293:Adolescent; D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood / Q000276:immunology; D005500:Follow-Up Studies; D006801:Humans; D008585:Meningitis, Meningococcal / Q000097:blood / Q000276:immunology / Q000517:prevention & control; D022401:Meningococcal Vaccines / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology*; D038582:Neisseria meningitidis, Serogroup W-135 / Q000276:immunology*; D011135:Polysaccharides, Bacterial / Q000276:immunology*; D015610:Serum Bactericidal Test / Q000379:methods; D016896:Treatment Outcome
chemical_list: D000907:Antibodies, Bacterial; D022401:Meningococcal Vaccines; D011135:Polysaccharides, Bacterial