title: [The effects of small dose of intratympanic gentamicin injection on intractable Meniere's disease].
abstract: OBJECTIVE
  To explore the efficacy of small dose of intratympanic gentamicin injection on intractable Meniere's disease.
  
  
  METHODS
  Retrospectively study the efficacy of gentamicin intratympanic injection on intractable Meniere's disease. The end-point of treatment was determined based on bedside tests (Spontaneous Nystagmus test, Head shaking test and Head Thrust test), hearing tests, or the improvement of patients symptoms.
  
  
  RESULTS
  Nineteen patients with Meniere's disease were treated with intratympanic gentamicin injection. Vertigo control was achieved in 17 patients (89%). Of them, vertigo of 5 patients was successfully controlled after single injection. Eight patients need double injections and 4 patients need the third injections to control the vertigo. Endolymphatic sac shunt was performed to 1 patient because he could not tolerate the fullness of ear due to injection. The remainder 2 patients with double injections showed no improvement of vertigo and rejected further treatment. Hearing was improved in two patients after gentamicin injection. Three patients complained of hearing loss after intratympanic gentamicin injection. The hearing of the other patients did not change.
  
  
  CONCLUSIONS
  Three weeks after using small dose of gentamicin intratympanic injection to treat intractable Meniere's disease, it was determined whether more injections is required. The results showed that by using this approach, the vertigo could be effectively controlled and the risk of hearing loss following intratympanic gentamicin injection could be reduced.
authors.affiliation: Department of Otology and Skull Base Surgery, Eye Ear Nose Throat Hospital, Fudan University, Shanghai, China. cfdai66@yahoo.com.cn
authors.forename: Chunfu
authors.initials: C
authors.lastname: Dai
authors.forename: Guoming
authors.initials: G
authors.lastname: Zhang
authors.forename: Ru
authors.initials: R
authors.lastname: Zhang
authors.forename: Jianping
authors.initials: J
authors.lastname: Liu
authors.forename: Fanglu
authors.initials: F
authors.lastname: Chi
authors.forename: Zhengmin
authors.initials: Z
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D004432:Ear, Middle; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008575:Meniere Disease / Q000150:complications / Q000188:drug therapy*; D008875:Middle Aged; D012189:Retrospective Studies; D014717:Vertigo / Q000188:drug therapy* / Q000209:etiology; D055815:Young Adult
chemical_list: D005839:Gentamicins