[Derangements of contractility of left ventricular myocardium in patients subjected to coronary bypass surgery. Methods of their correction].
Coronary bypass grafting with the use of cardiopulmonary bypass was performed in 119 patients (age 41-75 years) with stable angina. In addition to standard therapy in pre and post operative periods patients of group 1 (n=40) received mildronate (750 mg/day for 3 days then 750 mg twice weekly), patients of group 2 (n=41) received trimetazidine (70 mg/day). Patients of group 3 (n=38) received no "metabolic" drugs. The use of cardioprotectors mildronate and trimetazidine facilitated improvement of total and local myocardial contractility both before and after surgery, and caused limitation of development of myocardial stunning, associated with derangement of local contractility in post operative period.
Gordeev
I G
IG
Liusov
V A
VA
Il'ina
E E
EE
Baiandin
N L
NL
Kuznechevskiĭ
F V
FV
D000328:Adult; D000368:Aged; D000787:Angina Pectoris / Q000601:surgery; D002316:Cardiotonic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001026:Coronary Artery Bypass; D005260:Female; D006801:Humans; D008297:Male; D008763:Methylhydrazines / Q000494:pharmacology / Q000627:therapeutic use*; D008875:Middle Aged; D009200:Myocardial Contraction / Q000187:drug effects; D011183:Postoperative Complications / Q000188:drug therapy*; D014292:Trimetazidine / Q000494:pharmacology / Q000627:therapeutic use*; D018487:Ventricular Dysfunction, Left / Q000188:drug therapy* / Q000209:etiology
D002316:Cardiotonic Agents; D008763:Methylhydrazines; C050147:3-(2,2,2-trimethylhydrazine)propionate; D014292:Trimetazidine