Body mass index and oxidative DNA damage: a longitudinal study.
Leanness has been shown to be related to an increased risk of some cancer forms, including lung cancer. However, biological evidence supporting a causal link between leanness and carcinogenesis is limited. The authors investigated longitudinally the association between body mass index (BMI) and levels of urinary 8-hydroxydeoxyguanosine (8-OHdG), a marker of oxidative DNA damage, using data from 174 healthy employees who participated in a lifestyle intervention study. 8-OHdG levels were measured using automated high-performance liquid chromatography and adjusted for urinary creatinine levels. Analysis of repeated measurements using a random effects model detected a statistically significant inverse association between BMI and 8-OHdG levels (P = 0.003); one unit decrease in BMI was associated with a 2.7% (95% confidence interval 0.9-4.4) increase in 8-OHdG levels. The association was pronounced among men consuming less than 20 cigarettes per day (8.8% increase per unit decrease in BMI) and among non-smoking men (3.7% increase). The results based on a longitudinal observation suggest that weight loss is associated with increased oxidative DNA damage, a state presumably related to an increased risk of cancer.
Mizoue
Tetsuya
T
Department of Epidemiology and International Health, Research Institute, International Medical Center of Japan, Tokyo 162-8655, Japan. mizoue@ri.imcj.go.jp
Tokunaga
Shoji
S
Kasai
Hiroshi
H
Kawai
Kazuaki
K
Sato
Masao
M
Kubo
Tatsuhiko
T
D000080242:8-Hydroxy-2'-Deoxyguanosine; D000328:Adult; D015992:Body Mass Index; D001835:Body Weight; D004249:DNA Damage; D003849:Deoxyguanosine / Q000031:analogs & derivatives / Q000652:urine; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D012907:Smoking / Q000009:adverse effects*; D013851:Thinness
D000080242:8-Hydroxy-2'-Deoxyguanosine; D003849:Deoxyguanosine