The Sec14-superfamily and the regulatory interface between phospholipid metabolism and membrane trafficking.
A central principle of signal transduction is the appropriate control of the process so that relevant signals can be detected with fine spatial and temporal resolution. In the case of lipid-mediated signaling, organization and metabolism of specific lipid mediators is an important aspect of such control. Herein, we review the emerging evidence regarding the roles of Sec14-like phosphatidylinositol transfer proteins (PITPs) in the action of intracellular signaling networks; particularly as these relate to membrane trafficking. Finally, we explore developing ideas regarding how Sec14-like PITPs execute biological function. As Sec14-like proteins define a protein superfamily with diverse lipid (or lipophile) binding capabilities, it is likely these under-investigated proteins will be ultimately demonstrated as a ubiquitously important set of biological regulators whose functions influence a large territory in the signaling landscape of eukaryotic cells.
Mousley
Carl J
CJ
Department of Cell and Developmental Biology, Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7090, USA. carl_mousley@med.unc.edu
Tyeryar
Kimberly R
KR
Vincent-Pope
Patrick
P
Bankaitis
Vytas A
VA
D000818:Animals; D001692:Biological Transport; D002352:Carrier Proteins / Q000378:metabolism*; D003460:Crystallization; D006801:Humans; D008563:Membrane Lipids / Q000378:metabolism*; D053858:Metabolic Networks and Pathways; D008958:Models, Molecular; D010713:Phosphatidylcholines / Q000378:metabolism; D010716:Phosphatidylinositols / Q000378:metabolism; D049294:Phospholipid Transfer Proteins / Q000378:metabolism*; D010743:Phospholipids / Q000378:metabolism*; D011485:Protein Binding / Q000502:physiology; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*
D002352:Carrier Proteins; D008563:Membrane Lipids; D010713:Phosphatidylcholines; D010716:Phosphatidylinositols; D049294:Phospholipid Transfer Proteins; D010743:Phospholipids; C483438:SEC14 protein, S cerevisiae; C100642:SEC14L1 protein, human; D029701:Saccharomyces cerevisiae Proteins; C506000:Sec14p-like phosphoinositide-binding p45 protein, rat