title: Human cardiovascular dose-response to supplemental oxygen.
abstract: OBJECTIVE
  The aim of the study was to examine the central and peripheral cardiovascular adaptation and its coupling during increasing levels of hyperoxaemia. We hypothesized a dose-related effect of hyperoxaemia on left ventricular performance and the vascular properties of the arterial tree.
  
  
  METHODS
  Oscillometrically calibrated arterial subclavian pulse trace data were combined with echocardiographic recordings to obtain non-invasive estimates of left ventricular volumes, aortic root pressure and flow data. For complementary vascular parameters and control purposes whole-body impedance cardiography was applied. In nine (seven males) supine, resting healthy volunteers, aged 23-48 years, data was collected after 15 min of air breathing and at increasing transcutaneous oxygen tensions (20, 40 and 60 kPa), accomplished by a two group, random order and blinded hyperoxemic protocol.
  
  
  RESULTS
  Left ventricular stroke volume [86 +/- 13 to 75 +/- 9 mL (mean +/- SD)] and end-diastolic area (19.3 +/- 4.4 to 16.8 +/- 4.3 cm(2)) declined (P < 0.05), and showed a linear, negative dose-response relationship to increasing arterial oxygen levels in a regression model. Peripheral resistance and characteristic impedance increased in a similar manner. Heart rate, left ventricular fractional area change, end-systolic area, mean arterial pressure, arterial compliance or carbon dioxide levels did not change.
  
  
  CONCLUSIONS
  There is a linear dose-response relationship between arterial oxygen and cardiovascular parameters when the systemic oxygen tension increases above normal. A direct effect of supplemental oxygen on the vessels may therefore not be excluded. Proximal aortic and peripheral resistance increases from hyperoxaemia, but a decrease of venous return implies extra cardiac blood-pooling and compensatory relaxation of the capacitance vessels.
authors.affiliation: Department of Anesthesia and Intensive Care, and Departments of Hand and Plastic Surgery and Burn Intensive Care, University Hospital, Linköping, Sweden.
authors.forename: Z
authors.initials: Z
authors.lastname: Bak
authors.forename: F
authors.initials: F
authors.lastname: Sjöberg
authors.forename: A
authors.initials: A
authors.lastname: Rousseau
authors.forename: I
authors.initials: I
authors.lastname: Steinvall
authors.forename: B
authors.initials: B
authors.lastname: Janerot-Sjoberg
mesh_terms: D000328:Adult; D001794:Blood Pressure; D002302:Cardiac Output; D002307:Cardiography, Impedance / Q000379:methods; D002319:Cardiovascular System / Q000503:physiopathology*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D015150:Echocardiography, Doppler; D005260:Female; D006339:Heart Rate; D006801:Humans; D018496:Hyperoxia / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000008:administration & dosage; D012044:Regression Analysis; D013318:Stroke Volume; D013348:Subclavian Artery; D014655:Vascular Resistance; D016277:Ventricular Function, Left
chemical_list: D010100:Oxygen