Development and evaluation of carvedilol transdermal patches.
Transdermal patches of carvedilol with a HPMC-drug reservoir were prepared by the solvent evaporation technique. In this investigation, the membranes of Eudragit RL100 and Eudragit RS100 were cast to achieve controlled release of the drug. The prepared patches possessed satisfactory physicochemical characteristics. Thickness, mass and drug content were uniform in prepared batches. Moisture vapour transmission through the patches followed zero-order kinetics. In vitro permeation studies were performed using a K-C diffusion cell across hairless guinea pig skin and followed the super case II transport mechanism. The effects of non-ionic surfactants Tween 80 and Span 80 on drug permeation were studied. The nonionic surfactants in the patches increased the permeation rate, Span 80 exhibiting better enhancement relative to Tween 80. The patches were seemingly free of potentially hazardous skin irritation.
Tanwar
Yuveraj Singh
YS
Bhupal Nobles' College of Pharmacy, Udaipur-313001, Rajasthan, India. yuveraj@yahoo.co.in
Chauhan
Chetan Singh
CS
Sharma
Anshu
A
D000180:Acrylic Resins / Q000737:chemistry; D000279:Administration, Cutaneous; D000465:Algorithms; D000818:Animals; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D002227:Carbazoles / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D000077261:Carvedilol; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D004058:Diffusion; D004353:Drug Evaluation, Preclinical / Q000379:methods; D006168:Guinea Pigs; D007700:Kinetics; D008747:Methylcellulose / Q000737:chemistry; D010539:Permeability; D011136:Polysorbates / Q000737:chemistry; D011412:Propanolamines / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D011760:Pyrrolidinones / Q000737:chemistry; D011817:Rabbits; D012867:Skin / Q000378:metabolism*; D012869:Skin Absorption; D012995:Solubility; D013678:Technology, Pharmaceutical / Q000379:methods
D000180:Acrylic Resins; D000959:Antihypertensive Agents; D002227:Carbazoles; D003692:Delayed-Action Preparations; D011136:Polysorbates; D011412:Propanolamines; D011760:Pyrrolidinones; D000077261:Carvedilol; C050528:Eudragit RS; D008747:Methylcellulose