Ethambutol toxicity manifesting as acute onset psychosis.
Ethambutol is commonly used for the treatment of tuberculous and atypical mycobacterial infection. Central nervous system (CNS) toxicity other than optic neuropathy is not widely reported. A 40-year-old man with advanced HIV infection and Mycobacterium avium complex infection experienced rapid cognitive decline after commencement of ethambutol, and symptoms fully resolved with cessation.
Martin
S J
SJ
Canberra Sexual Health Centre, The Canberra Hospital, Canberra, ACT, Australia. sarah.martin@act.gov.au
Bowden
F J
FJ
D000328:Adult; D000995:Antitubercular Agents / Q000009:adverse effects*; D004359:Drug Therapy, Combination; D004977:Ethambutol / Q000009:adverse effects*; D006801:Humans; D008297:Male; D015270:Mycobacterium avium-intracellulare Infection / Q000188:drug therapy*; D011605:Psychoses, Substance-Induced / Q000209:etiology*
D000995:Antitubercular Agents; D004977:Ethambutol