[Combined action of mexidol and non-narcotic analgesics on pain thresholds and emotional stress behavior in animals].
The influence of non-narcotic analgesics analgin and pentalgin in the basic pharmacological effects of diazepam and mexidol has been studied in outbred male albino rats. It is established that both analgesics do not influence the activity of diazepam. At the same time, they potentiate the analgesic action of mexidol without influencing its antistress action and not inducing any side effects. The strengthening influence of pentalgin was more pronounced. It is concluded that mexidol can be administered in combination with non-narcotic analgesics, in particular with pentalgin, for relieving painful syndrome on the background of stress.
Molodavkin
G M
GM
Voronina
T A
TA
Larentsova
L I
LI
Pchelkina
M I
MI
Meletova
O K
OK
D000082:Acetaminophen / Q000009:adverse effects / Q000494:pharmacology; D018712:Analgesics, Non-Narcotic / Q000009:adverse effects / Q000494:pharmacology*; D000818:Animals; D014151:Anti-Anxiety Agents / Q000009:adverse effects / Q000494:pharmacology*; D002110:Caffeine / Q000009:adverse effects / Q000494:pharmacology; D003061:Codeine / Q000009:adverse effects / Q000494:pharmacology; D003975:Diazepam / Q000009:adverse effects / Q000494:pharmacology*; D004177:Dipyrone / Q000009:adverse effects / Q000494:pharmacology*; D004338:Drug Combinations; D004347:Drug Interactions; D008297:Male; D017288:Pain Threshold; D010634:Phenobarbital / Q000009:adverse effects / Q000494:pharmacology; D010847:Picolines / Q000009:adverse effects / Q000494:pharmacology*; D051381:Rats; D013315:Stress, Psychological / Q000188:drug therapy*
D018712:Analgesics, Non-Narcotic; D014151:Anti-Anxiety Agents; D004338:Drug Combinations; D010847:Picolines; C070020:emoxypine succinate; D000082:Acetaminophen; D002110:Caffeine; D004177:Dipyrone; D003975:Diazepam; D003061:Codeine; D010634:Phenobarbital