Highly enantioselective organocatalytic direct aldol reaction in an aqueous medium.
We have demonstrated that small organic molecules 1 and 2 catalyzed the direct aldol reaction of both acyclic and cyclic ketones with different aldehydes in an excess of water/brine. Excellent enantioselectivities up to >99% and diastereoselectivities up to 99% with very good yields were obtained by using much lower catalyst loadings (0.5 mol %).
Maya
Vishnu
V
Deparment of Chemistry, Indian Institute of Technology Kanpur, India 208 016.
Raj
Monika
M
Singh
Vinod K
VK