title: Cardiac amyloidosis: MR imaging findings and T1 quantification, comparison with control subjects.
abstract: In cardiac amyloidosis an interstitial deposition of amyloid fibrils causes concentric thickening of the atrial and ventricular walls. We describe the results of tissue characterization of the myocardium by T1 quantification and MRI findings in a patient with cardiac amyloidosis. The T1 time of the myocardium was elevated compared to that in individuals without amyloidosis. The T1 time of the myocardium was 1387 +/- 63 msec (mean value obtained from four measurements +/- standard deviation [SD]) in the patient with cardiac amyloidosis, while the reference value obtained from the myocardium of 10 individuals without known myocardial disease was 1083 +/- 33 msec (mean value +/- SD). In combination with other MR findings suggestive of amyloidosis, such as homogeneous thickening of the ventricular and atrial walls, thickening of the valve leaflets, restrictive filling pattern, and reduction of systolic function, T1 quantification may increase diagnostic confidence.
authors.affiliation: Department of Diagnostic Radiology, University Hospital, Pauwelsstrasse 30, 52057 Aachen, Germany. krombach@rad.rwth-aachen.de
authors.forename: Gabriele A
authors.initials: GA
authors.lastname: Krombach
authors.forename: Christa
authors.initials: C
authors.lastname: Hahn
authors.forename: Maren
authors.initials: M
authors.lastname: Tomars
authors.forename: Arno
authors.initials: A
authors.lastname: Buecker
authors.forename: Armin
authors.initials: A
authors.lastname: Grawe
authors.forename: Rolf W
authors.initials: RW
authors.lastname: Günther
authors.forename: Harald P
authors.initials: HP
authors.lastname: Kühl
mesh_terms: D000686:Amyloidosis / Q000175:diagnosis*; D009202:Cardiomyopathies / Q000175:diagnosis*; D016022:Case-Control Studies; D003287:Contrast Media; D003937:Diagnosis, Differential; D015150:Echocardiography, Doppler; D004562:Electrocardiography; D019786:Gadolinium DTPA; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA