title: Highly enantioselective Friedel-Crafts alkylations of indoles with simple enones catalyzed by zirconium(IV)-BINOL complexes.
abstract: Complexes of BINOL-based ligands with Zr(OtBu)4 catalyze the Friedel-Crafts alkylation reaction of indoles and pyrrole with nonchelating beta-substituted alpha,beta-enones at room temperature affording the expected products with good yields and ee above 95% in most of the studied examples.
authors.affiliation: Departament de Química Orgànica, Facultat de Química, Universitat de València, E-46100-Burjassot, València, Spain.
authors.forename: Gonzalo
authors.initials: G
authors.lastname: Blay
authors.forename: Isabel
authors.initials: I
authors.lastname: Fernández
authors.forename: José R
authors.initials: JR
authors.lastname: Pedro
authors.forename: Carlos
authors.initials: C
authors.lastname: Vila