Fungal infections in solid organ transplantation.
Fungal infections in solid organ transplant recipients continue to be a significant cause of morbidity and mortality. Candida spp. and Aspergillus spp. account for most invasive fungal infections. The incidence of fungal infection varies with type of solid organ transplant. Liver transplant recipients have highest reported incidence of candida infections while lung transplant recipients have highest rate of Aspergillus infections. Recent epidemiological studies suggest the emergence of resistant strains of candida as well as mycelial fungi other than Aspergillus in these patients. The current review incorporates the recent changes in the epidemiology of fungal infections in solid organ transplant recipients and highlights the newer data on the diagnosis, prophylaxis and treatment of fungal infections in these patients.
Silveira
Fernanda P
FP
Division of Infectious Diseases, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Husain
Shahid
S
D000935:Antifungal Agents / Q000627:therapeutic use; D001228:Aspergillosis / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000628:therapy; D001759:Blastomycosis / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000628:therapy; D002177:Candidiasis / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000628:therapy; D003047:Coccidioidomycosis / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000628:therapy; D003453:Cryptococcosis / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000628:therapy; D006660:Histoplasmosis / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000628:therapy; D006801:Humans; D008172:Lung Diseases, Fungal / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000628:therapy; D009181:Mycoses / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000628:therapy; D016377:Organ Transplantation / Q000009:adverse effects*; D012307:Risk Factors
D000935:Antifungal Agents