Overcoming opioid blockade from depot naltrexone (Prodetoxon).
OBJECTIVE
To describe a situation in which an opioid-dependent patient overcame naltrexone blockade. DESIGN, CASE REPORT, SETTING: Addiction treatment center in St Petersburg, Russia.


METHODS
Patient with naltrexone implant.


METHODS
Detoxification.


METHODS
Clinical observations.


CONCLUSIONS
It is possible, but very difficult, to overcome naltrexone blockade by using large doses of heroin.
Kruptisky
E M
EM
St Petersburg Regional Center in Addiction and Psychopharmacology affiliated with Pavlov State Medical University, St Petersburg, Russia.
Burakov
A M
AM
Tsoy
M V
MV
Egorova
V Y
VY
Slavina
T Y
TY
Grinenko
A Y
AY
Zvartau
E E
EE
Woody
G E
GE
D000328:Adult; D004343:Drug Implants / Q000627:therapeutic use*; D006556:Heroin Dependence / Q000188:drug therapy*; D006801:Humans; D008658:Inactivation, Metabolic; D008297:Male; D009271:Naltrexone / Q000493:pharmacokinetics / Q000627:therapeutic use*; D009292:Narcotic Antagonists / Q000493:pharmacokinetics / Q000627:therapeutic use*; D055502:Secondary Prevention; D013375:Substance Withdrawal Syndrome / Q000628:therapy
D004343:Drug Implants; D009292:Narcotic Antagonists; D009271:Naltrexone