title: Vagus nerve stimulation in children with mitochondrial electron transport chain deficiencies.
abstract: We retrospectively investigated outcome data for vagus nerve stimulation (VNS) in children less than 12 years of age with intractable seizures and mitochondrial disease. Five children with a mitochondrial disease, due to electron transport chain deficiency, were studied. Information was collected from clinic visits prior to, and subsequent to, VNS implantation. Data were collected by type and frequency of seizures, encephalogram and neuroimaging findings, and medication history. Four of the children had predominantly myoclonic seizures, while the other child had focal seizures with secondary generalization and myoclonic seizures. All five children did not have significant reduction in seizure frequency with VNS. VNS may not be an effective method to control myoclonic seizures in children with electron transport chain disorders.
authors.affiliation: Division of Pediatric Neurology, Children's Hospital and Regional Medical Center/University of Washington, B-5552, 4800 Sand Point Way NE, Seattle, WA 98105, USA.
authors.forename: Todd M
authors.initials: TM
authors.lastname: Arthur
authors.forename: Russell P
authors.initials: RP
authors.lastname: Saneto
authors.forename: Marcio Sotero
authors.initials: MS
authors.lastname: de Menezes
authors.forename: Orrin
authors.initials: O
authors.lastname: Devinsky
authors.forename: Josiane
authors.initials: J
authors.lastname: Lajoie
authors.forename: Patricia J
authors.initials: PJ
authors.lastname: Murphy
authors.forename: William B
authors.initials: WB
authors.lastname: Cook
authors.forename: Jeffrey G
authors.initials: JG
authors.lastname: Ojemann
mesh_terms: D002648:Child; D002675:Child, Preschool; D004827:Epilepsy / Q000473:pathology; D006801:Humans; D007223:Infant; D008854:Microscopy, Electron; D028361:Mitochondrial Diseases / Q000473:pathology*; D014630:Vagus Nerve