title: CX3CR1 polymorphisms are associated with atopy but not asthma in German children.
abstract: Chemokines and their receptors are involved in many aspects of immunity. Chemokine CX3CL1, acting via its receptor CX3CR1, regulates monocyte migration and macrophage differentiation as well as T cell-dependent inflammation. Two common, nonsynonymous polymorphisms in CX3CR1 have previously been shown to alter the function of the CX3CL1/CX3CR1 pathway and were suggested to modify the risk for asthma. Using matrix-assisted laser desorption/ionization time-of-flight technology, we genotyped polymorphisms Val249Ile and Thr280Met in a cross-sectional population of German children from Munich (n = 1,159) and Dresden (n = 1,940). For 249Ile an odds ratio of 0.77 (95% confidence interval 0.63-0.96; p = 0.017) and for 280Met an odds ratio of 0.71 (95% confidence interval 0.56-0.89; p = 0.004) were found with atopy in Dresden but not in Munich. Neither polymorphism was associated with asthma. Thus, amino acid changes in CX3CR1 may influence the development of atopy but not asthma in German children. Potentially, other factors such as environmental effects may modify the role of CX3CR1 polymorphisms.
authors.affiliation: University Children's Hospital, Ludwig Maximilians University Munich, Munich, Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Depner
authors.forename: Michael S D
authors.initials: MS
authors.lastname: Kormann
authors.forename: Norman
authors.initials: N
authors.lastname: Klopp
authors.forename: Thomas
authors.initials: T
authors.lastname: Illig
authors.forename: Christian
authors.initials: C
authors.lastname: Vogelberg
authors.forename: Stephan K
authors.initials: SK
authors.lastname: Weiland
authors.forename: Erika
authors.initials: E
authors.lastname: von Mutius
authors.forename: Christophe
authors.initials: C
authors.lastname: Combadière
authors.forename: Michael
authors.initials: M
authors.lastname: Kabesch
mesh_terms: D019943:Amino Acid Substitution / Q000235:genetics; D001249:Asthma / Q000235:genetics* / Q000276:immunology*; D000073883:CX3C Chemokine Receptor 1; D002648:Child; D020022:Genetic Predisposition to Disease; D005858:Germany; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000235:genetics* / Q000276:immunology*; D011110:Polymorphism, Genetic / Q000276:immunology; D019707:Receptors, Chemokine / Q000235:genetics*
chemical_list: D000073883:CX3C Chemokine Receptor 1; C095235:CX3CR1 protein, human; D019707:Receptors, Chemokine