title: Metastatic mucinous cystic adenocarcinoma of the pancreas presenting as Sister Mary Joseph's nodule.
abstract: BACKGROUND
  Sister Mary Joseph's nodule usually represents metastatic cancers from gastrointestinal malignancy including adenocarcinoma of the pancreas. Mucinous cystadenocarcinoma is a rare malignancy of the pancreas. However, pancreatic mucinous cystadenocarcinoma metastasized to Sister Mary Joseph's nodule is much rarer and has never been reported before.
  
  
  METHODS
  A 73-year-old Thai woman presented with progressive epigastric discomfort, severe back pain and significant weight loss over a 3 month period. Physical examination revealed right supraclavicular lymphadenopathy and Sister Mary Joseph's nodule at the umbilicus. A CT scan showed a large cystic lesion with internal septation at the pancreatic tail. Cyst fluid analysis revealed a brown mucoid fluid having high carcinoembryonic antigen and carbohydrate antigen 19-9 levels. Skin biopsy from the nodule confirmed the presence of metastatic mucinous cystadenocarcinoma.
  
  
  CONCLUSIONS
  To our knowledge, this is the first report of pancreatic mucinous cystadenocarcinoma metastasized as Sister Mary Joseph's nodule.
authors.affiliation: Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
authors.forename: Danai
authors.initials: D
authors.lastname: Limmathurotsakul
authors.forename: Pawinee
authors.initials: P
authors.lastname: Rerknimitr
authors.forename: Wiwat
authors.initials: W
authors.lastname: Korkij
authors.forename: Nopadon
authors.initials: N
authors.lastname: Noppakun
authors.forename: Pinit
authors.initials: P
authors.lastname: Kullavanijaya
authors.forename: Rungsun
authors.initials: R
authors.lastname: Rerknimitr
mesh_terms: D000368:Aged; D001707:Biopsy, Needle; D018395:CA-19-9 Antigen / Q000097:blood; D002272:Carcinoembryonic Antigen / Q000097:blood; D018282:Cystadenocarcinoma, Mucinous / Q000175:diagnosis / Q000473:pathology* / Q000556:secondary*; D005260:Female; D006801:Humans; D010190:Pancreatic Neoplasms / Q000175:diagnosis / Q000473:pathology*; D012878:Skin Neoplasms / Q000556:secondary*; D014472:Umbilicus / Q000473:pathology*
chemical_list: D018395:CA-19-9 Antigen; D002272:Carcinoembryonic Antigen