Vitamin-loaded electrospun cellulose acetate nanofiber mats as transdermal and dermal therapeutic agents of vitamin A acid and vitamin E.
The present contribution reports the use of mats of electrospun cellulose acetate (CA; acetyl content=39.8%; Mw=30,000 Da) nanofibers as carriers for delivery of the model vitamins, all-trans retinoic acid or vitamin A acid (Retin-A) and alpha-tocopherol or vitamin E (Vit-E). The amounts of Vit-E and Retin-A loaded in the base CA solution [17% w/v in 2:1 v/v acetone/N,N-dimethylacetamide (DMAc)] were 5 and 0.5 wt% (based on the weight of CA), respectively. Cross-sectionally round and smooth fibers were obtained. The average diameters of these fibers ranged between 247 and 265 nm. The total immersion of the vitamin-loaded as-spun CA fiber mats in the acetate buffer solutions containing either 0.5 vol % Tween 80 or 0.5 vol % Tween 80 and 10 vol % methanol was used to arrive at the cumulative release of the vitamins from the fiber mat samples. The same was also conducted on the vitamin-loaded solution-cast CA films for comparison. In most cases, the vitamin-loaded as-spun fiber mats exhibited a gradual and monotonous increase in the cumulative release of the vitamins over the test periods (i.e., 24 h for Vit-E-loaded samples and 6 h for Retin-A-loaded ones), while the corresponding as-cast films exhibited a burst release of the vitamins.
Taepaiboon
Pattama
P
Technological Center for Electrospun Fibers and The Petroleum and Petrochemical College, Chulalongkorn University, Pathumwan Bangkok 10330, Thailand.
Rungsardthong
Uracha
U
Supaphol
Pitt
P
D000085:Acetates / Q000737:chemistry; D000279:Administration, Cutaneous; D002021:Buffers; D002482:Cellulose / Q000031:analogs & derivatives* / Q000737:chemistry; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D004333:Drug Administration Routes; D004563:Electrochemistry / Q000379:methods; D008855:Microscopy, Electron, Scanning; D008956:Models, Chemical; D053758:Nanoparticles / Q000737:chemistry*; D012867:Skin / Q000187:drug effects*; D013314:Stress, Mechanical; D014212:Tretinoin / Q000737:chemistry*; D014810:Vitamin E / Q000737:chemistry*; D014815:Vitamins / Q000737:chemistry
D000085:Acetates; D002021:Buffers; D014815:Vitamins; D014810:Vitamin E; C005062:acetylcellulose; D014212:Tretinoin; D002482:Cellulose