Genome sequence of Aedes aegypti, a major arbovirus vector.
We present a draft sequence of the genome of Aedes aegypti, the primary vector for yellow fever and dengue fever, which at approximately 1376 million base pairs is about 5 times the size of the genome of the malaria vector Anopheles gambiae. Nearly 50% of the Ae. aegypti genome consists of transposable elements. These contribute to a factor of approximately 4 to 6 increase in average gene length and in sizes of intergenic regions relative to An. gambiae and Drosophila melanogaster. Nonetheless, chromosomal synteny is generally maintained among all three insects, although conservation of orthologous gene order is higher (by a factor of approximately 2) between the mosquito species than between either of them and the fruit fly. An increase in genes encoding odorant binding, cytochrome P450, and cuticle domains relative to An. gambiae suggests that members of these protein families underpin some of the biological differences between the two mosquito species.
Nene
Vishvanath
V
Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA. nene@tigr.org
Wortman
Jennifer R
JR
Lawson
Daniel
D
Haas
Brian
B
Kodira
Chinnappa
C
Tu
Zhijian Jake
ZJ
Loftus
Brendan
B
Xi
Zhiyong
Z
Megy
Karyn
K
Grabherr
Manfred
M
Ren
Quinghu
Q
Zdobnov
Evgeny M
EM
Lobo
Neil F
NF
Campbell
Kathryn S
KS
Brown
Susan E
SE
Bonaldo
Maria F
MF
Zhu
Jingsong
J
Sinkins
Steven P
SP
Hogenkamp
David G
DG
Amedeo
Paolo
P
Arensburger
Peter
P
Atkinson
Peter W
PW
Bidwell
Shelby
S
Biedler
Jim
J
Birney
Ewan
E
Bruggner
Robert V
RV
Costas
Javier
J
Coy
Monique R
MR
Crabtree
Jonathan
J
Crawford
Matt
M
Debruyn
Becky
B
Decaprio
David
D
Eiglmeier
Karin
K
Eisenstadt
Eric
E
El-Dorry
Hamza
H
Gelbart
William M
WM
Gomes
Suely L
SL
Hammond
Martin
M
Hannick
Linda I
LI
Hogan
James R
JR
Holmes
Michael H
MH
Jaffe
David
D
Johnston
J Spencer
JS
Kennedy
Ryan C
RC
Koo
Hean
H
Kravitz
Saul
S
Kriventseva
Evgenia V
EV
Kulp
David
D
Labutti
Kurt
K
Lee
Eduardo
E
Li
Song
S
Lovin
Diane D
DD
Mao
Chunhong
C
Mauceli
Evan
E
Menck
Carlos F M
CF
Miller
Jason R
JR
Montgomery
Philip
P
Mori
Akio
A
Nascimento
Ana L
AL
Naveira
Horacio F
HF
Nusbaum
Chad
C
O'leary
Sinéad
S
Orvis
Joshua
J
Pertea
Mihaela
M
Quesneville
Hadi
H
Reidenbach
Kyanne R
KR
Rogers
Yu-Hui
YH
Roth
Charles W
CW
Schneider
Jennifer R
JR
Schatz
Michael
M
Shumway
Martin
M
Stanke
Mario
M
Stinson
Eric O
EO
Tubio
Jose M C
JM
Vanzee
Janice P
JP
Verjovski-Almeida
Sergio
S
Werner
Doreen
D
White
Owen
O
Wyder
Stefan
S
Zeng
Qiandong
Q
Zhao
Qi
Q
Zhao
Yongmei
Y
Hill
Catherine A
CA
Raikhel
Alexander S
AS
Soares
Marcelo B
MB
Knudson
Dennis L
DL
Lee
Norman H
NH
Galagan
James
J
Salzberg
Steven L
SL
Paulsen
Ian T
IT
Dimopoulos
George
G
Collins
Frank H
FH
Birren
Bruce
B
Fraser-Liggett
Claire M
CM
Severson
David W
DW
D000330:Aedes / Q000235:genetics* / Q000378:metabolism; D000818:Animals; D000852:Anopheles / Q000235:genetics / Q000378:metabolism; D001103:Arboviruses; D001483:Base Sequence; D004251:DNA Transposable Elements; D003715:Dengue / Q000517:prevention & control / Q000635:transmission; D004331:Drosophila melanogaster / Q000235:genetics; D005260:Female; D017344:Genes, Insect; D049750:Genome, Insect; D006801:Humans; D019476:Insect Proteins / Q000235:genetics; D007303:Insect Vectors / Q000235:genetics* / Q000378:metabolism; D008297:Male; D026901:Membrane Transport Proteins / Q000235:genetics; D008969:Molecular Sequence Data; D005810:Multigene Family; D017434:Protein Structure, Tertiary / Q000235:genetics; D017422:Sequence Analysis, DNA; D012727:Sex Characteristics; D019849:Sex Determination Processes; D013045:Species Specificity; D026801:Synteny; D014158:Transcription, Genetic; D015004:Yellow Fever / Q000517:prevention & control / Q000635:transmission
D004251:DNA Transposable Elements; D019476:Insect Proteins; D026901:Membrane Transport Proteins