The beneficial effects of statins in autoimmune disease therapy.
Statins, HMG-CoA reductase inhibitors, are widely used for the treatment of hypercholesterolemia and the prevention of cardiovascular diseases. Recent experimental and clinical studies evaluated the effect of statins on immune and inflammatory cells, and the efficacy of statins in treatment of immune diseases. This review discusses the roles of statins in the treatment of immune and inflammatory diseases.
Marai
Ibrahim
I
Heart Institute, Sheba Medical Center, Tel-Hashomer, Sackler Faculty of Medicine, Tel-Aviv University, Israel.
Shoenfeld
Yehuda
Y
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use; D001327:Autoimmune Diseases / Q000188:drug therapy*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D007155:Immunologic Factors / Q000494:pharmacology / Q000627:therapeutic use
D000893:Anti-Inflammatory Agents; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D007155:Immunologic Factors