The impact of positive end-expiratory pressure on functional residual capacity and ventilation homogeneity impairment in anesthetized children exposed to high levels of inspired oxygen.
BACKGROUND
High fractions of inspired oxygen (Fio2) result in resorption atelectasis shortly after their application. However, the impact of different levels of Fio2 and their interaction with positive end-expiratory pressure (PEEP) on functional residual capacity (FRC) and ventilation distribution is unknown in anesthetized children. We hypothesized that the use of a Fio2 of 1.0 results in a decrease of FRC and ventilation homogeneity compared with that of a Fio2 of 0.3, and that this decrease is prevented by PEEP of 6-cm H2O compared to a PEEP of 3-cm H2O.


METHODS
Forty-six children (3-6 yr) without cardiopulmonary disease were randomly allocated to receive PEEP of 6-cm H2O (PEEP 6 group) during the entire study period or PEEP of 3-cm H2O (PEEP 3 group). The order of the Fio2 (0.3 or 1.0) was also randomized. A defined recruitment maneuver was performed after tracheal intubation and 5 min later the first measurement. This procedure was then repeated with the second Fio2 level. FRC and lung clearance index (LCI) were calculated by a blinded observer.


RESULTS
While FRC (mean +/- sd) was similar at both levels of Fio2 (0.3: 25.6 +/- 2.9 mL/kg vs 1.0: 25.6 +/- 2.8 mL/kg, P = 0.189) in the PEEP 6 group, FRC decreased in the PEEP 3 group (0.3: 24.9 +/- 3.8 vs 1.0: 21.7 +/- 4.1, P < 0.0001). Furthermore, with continuous PEEP of 6-cm H2O a similar LCI was observed at both levels of Fio2 (0.3: 6.45 +/- 0.4 vs 6.43 +/- 0.4, P = 0.668) while LCI increased at the higher Fio2 in the PEEP 3 group (0.3: 6.5 +/- 0.5 vs 1.0: 7.7 +/- 1.2, P < 0.0001).


CONCLUSIONS
During the application of a very low PEEP of 3-cm H2O, FRC and ventilation distribution decreased significantly at an Fio2 of 1.0 compared with that at an Fio2 of 0.3. This decrease could be counterbalanced by the administration of PEEP of 6-cm H2O, indicating that a low level of PEEP is sufficient to maintain FRC and ventilation distribution regardless of the oxygen concentration.
von Ungern-Sternberg
Britta S
BS
Division of Anesthesia, University Children's Hospital, Basel, Switzerland. bvonungern@uhbs.ch
Regli
Adrian
A
Schibler
Andreas
A
Hammer
Jürg
J
Frei
Franz J
FJ
Erb
Thomas O
TO
D000768:Anesthesia, General / Q000379:methods; D002648:Child; D002675:Child, Preschool; D005260:Female; D005652:Functional Residual Capacity / Q000187:drug effects / Q000502:physiology; D006801:Humans; D001239:Inhalation / Q000187:drug effects / Q000502:physiology*; D008297:Male; D010100:Oxygen / Q000008:administration & dosage*; D011175:Positive-Pressure Respiration / Q000379:methods; D012123:Pulmonary Ventilation / Q000187:drug effects / Q000502:physiology*; D012115:Residual Volume / Q000187:drug effects / Q000502:physiology; D014109:Total Lung Capacity / Q000502:physiology*
D010100:Oxygen