The organophosphate-induced acute-phase response is characterized by synthesis of alpha 1-acid glycoprotein that exhibits an immunomodulatory effect.
The organophosphorus compounds soman and paraoxon induce the acute-phase (AP) response. All phases of the AP response, from macrophage activation and stimulation of glucocorticoid secretion to AP protein expression appear to be under the control of similar molecular mechanisms to those during the turpentine-induced AP response. The AP protein content in the circulation 24 h after either soman, paraoxon or turpentine administration was injury-specific. Both soman and paraoxon poisoning were characterized by significantly increased synthesis of alpha(1)-acid glycoprotein (AGP) that displayed an immunomodulatory effect in vitro. This result suggests that after organophosphate poisoning AGP participates in vivo in a negative feedback mechanism that prevents over-activity of the immune system.
Ivanović-Matić
Svetlana
S
Department of Molecular Biology, Institute for Biological Research, Bulevar despota Stefana 142, 11060 Belgrade, Serbia. smatic@ibiss.bg.ac.yu
Poznanović
Goran
G
Grigorov
Ilijana
I
Dinić
Svetlana
S
Mihailović
Mirjana
M
Grdović
Nevena
N
Uskoković
Aleksandra
A
Martinović
Vesna
V
Arambasić
Jelena
J
Petrović
Miodrag
M
Bogojević
Desanka
D
D000209:Acute-Phase Proteins / Q000235:genetics / Q000276:immunology; D000818:Animals; D002478:Cells, Cultured; D003345:Corticosterone / Q000097:blood; D007155:Immunologic Factors / Q000235:genetics / Q000276:immunology* / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects / Q000276:immunology; D008297:Male; D009961:Orosomucoid / Q000235:genetics / Q000276:immunology* / Q000494:pharmacology; D010261:Paraoxon / Q000633:toxicity*; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012999:Soman / Q000633:toxicity*; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D014425:Turpentine / Q000633:toxicity
D000209:Acute-Phase Proteins; D007155:Immunologic Factors; D009961:Orosomucoid; D012333:RNA, Messenger; D012999:Soman; D010261:Paraoxon; D003345:Corticosterone; D014425:Turpentine