Estradiol augments peri-infarct cerebral vascular density in experimental stroke.
Peri-infarct increase of vascular density has been observed in animals and in humans with ischemic stroke. Increased peri-infarct vascular density correlates with improved functional outcome after stroke. We hypothesized that pre-treatment with estradiol will increase post-ischemic peri-infarct capillary density in a rat model of transient ischemic stroke. Estradiol, compared to placebo, augmented post-ischemic peri-infarct vascular density by 22% 10 days after stroke. Recovery of forelimb function was not improved with estradiol treatment on day three and nine post-stroke. Loss of estradiol may limit repair in the peri-infarct region by limiting angiogenesis, but functional significance in stroke recovery requires further investigation.
Ardelt
Agnieszka A
AA
University of Alabama at Birmingham, Department of Neurology, Comprehensive Stroke Center, 1813 6th Avenue South, Suite M226 RWUH, Birmingham, AL 35294, USA. aardelt1@uab.edu
Anjum
Naseem
N
Rajneesh
Kiran F
KF
Kulesza
Piotr
P
Koehler
Raymond C
RC
D043925:Angiogenesis Inducing Agents / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D020520:Brain Infarction / Q000188:drug therapy* / Q000503:physiopathology; D002196:Capillaries / Q000187:drug effects / Q000502:physiology; D002536:Cerebral Arteries / Q000187:drug effects* / Q000503:physiopathology; D004195:Disease Models, Animal; D004958:Estradiol / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D005552:Forelimb / Q000294:innervation / Q000503:physiopathology; D008833:Microcirculation / Q000187:drug effects / Q000502:physiology; D009044:Motor Cortex / Q000098:blood supply / Q000187:drug effects / Q000503:physiopathology; D018919:Neovascularization, Physiologic / Q000187:drug effects* / Q000502:physiology; D010291:Paresis / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology; D051381:Rats; D017208:Rats, Wistar; D020127:Recovery of Function / Q000187:drug effects / Q000502:physiology; D020521:Stroke / Q000188:drug therapy* / Q000503:physiopathology; D013687:Telencephalon / Q000098:blood supply / Q000187:drug effects / Q000503:physiopathology; D016896:Treatment Outcome
D043925:Angiogenesis Inducing Agents; D004958:Estradiol