title: [Sleep apnea syndrome].
abstract: The association between gastroesophageal reflux disease (GERD) and obstructive sleep apnea syndrome (OSAS) has recently been suggested. Patients with OSAS have a high frequency of nocturnal GER, and patients with GERD have various sleep-related symptom such as snoring and apnea. However, the causal relation between OSAS and GERD has not been sufficiently elucidated. The treatment of OSAS with nasal continuous positive airway pressure significantly reduces GERD symptom and nocturnal GER in both patients with and without OSAS. On the other hand, treatment of GERD in patients with OSAS improves the number of arousal during sleep, but one study showed a significant decline of apnea index. It is necessary to make further studies evaluating the association and treatment of OSAS and GERD.
authors.affiliation: Department of Gastroenterology, KKR Sapporo Medical Center.
authors.forename: Junichi
authors.initials: J
authors.lastname: Suzuki
authors.forename: Nozomu
authors.initials: N
authors.lastname: Sugai
mesh_terms: D045422:Continuous Positive Airway Pressure; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D005764:Gastroesophageal Reflux / Q000150:complications* / Q000628:therapy; D006801:Humans; D054328:Proton Pump Inhibitors; D020181:Sleep Apnea, Obstructive / Q000150:complications* / Q000628:therapy
chemical_list: D004791:Enzyme Inhibitors; D054328:Proton Pump Inhibitors