Exploring effects of different nonsteroidal antiinflammatory drugs on malondialdehyde profile.
As a part of our ongoing effort to explore drug induced lipid peroxidation in relation to drug-induced toxicity, this study was undertaken to determine whether nonsteroidal anti-inflammatory drugs (NSAIDs), namely, diclofenac sodium, ibuprofen, flurbiprofen, paracetamol, nimesulide, celecoxib and indomethacin are involved in oxidative/antioxidative processes by determining malondialdehyde (MDA) concentration as an index of lipid peroxidation. Considering lipid peroxidation, a possible mediator of toxicity, an attempt was made to see the suppressive action of ascorbic acid, a conventional antioxidant compound, on NSAID-induced lipid peroxidation. It was found that diclofenac sodium, ibuprofen, flurbiprofen and paracetamol exerted statistically significant decrease of MDA content, suggesting a potential of the molecules to suppress the lipid peroxidation. At earlier stage of incubation nimesulide shows statistically significant decrease of MDA content followed by lipid peroxidation induction at the later stage of incubation period, suggesting involvement of nimesulide in antioxidative/oxidative processes. Celecoxib and indomethacin both exerted statistically significant increase of MDA content, representing significant peroxidation activity. Ascorbic acid, a promising antioxidant, could significantly reduce celecoxib and indomethacin induced lipid peroxidation.
Chakraborty
Santanu
S
Division of Medicinal and Pharmaceutical Chemistry, Department of Pharmaceutical Technology, Jadavpur University, Kolkata-700 032, India.
Kar
Sudip Kumar
SK
Roy
Kunal
K
Sengupta
Chandana
C
D000082:Acetaminophen / Q000494:pharmacology; D000704:Analysis of Variance; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D000068579:Celecoxib; D004008:Diclofenac / Q000494:pharmacology; D005480:Flurbiprofen / Q000494:pharmacology; D006041:Goats; D007052:Ibuprofen / Q000494:pharmacology; D007213:Indomethacin / Q000494:pharmacology; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008315:Malondialdehyde / Q000378:metabolism*; D011720:Pyrazoles / Q000494:pharmacology; D013449:Sulfonamides / Q000494:pharmacology; D013997:Time Factors
D000894:Anti-Inflammatory Agents, Non-Steroidal; D011720:Pyrazoles; D013449:Sulfonamides; D004008:Diclofenac; D000082:Acetaminophen; D008315:Malondialdehyde; D005480:Flurbiprofen; D000068579:Celecoxib; C012655:nimesulide; D007052:Ibuprofen; D007213:Indomethacin