Evolution of the carboxylate Jen transporters in fungi.
Synteny analysis is combined with sequence similarity and motif identification to trace the evolution of the putative monocarboxylate (lactate/pyruvate) transporters Jen1p and the dicarboxylate (succinate/fumarate/malate) transporters Jen2p in Hemiascomycetes yeasts and Euascomycetes fungi. It is concluded that a precursor form of Jen1p, named here preJen1p, arose by the duplication of an ancestral Jen2p, during the speciation of Yarrowia lipolytica, which was transferred into a new syntenic context. The Jen1p transporters differentiated from preJen1p in Kluyveromyces lactis, before the Whole Genome Duplication (WGD), and are conserved as a single copy in the Saccharomyces species. In contrast, the ancestral Jen2p was definitively lost just prior to the WGD and is absent in Saccharomyces.
Lodi
Tiziana
T
Dipartimento di Genetica Biologia dei Microrganismi Antropologia Evoluzione, Università di Parma, Parma, Italy. tiziana.lodi@unipr.it
Diffels
Julie
J
Goffeau
André
A
Baret
Philippe V
PV
D000595:Amino Acid Sequence; D001203:Ascomycota / Q000145:classification / Q000235:genetics* / Q000378:metabolism; D019143:Evolution, Molecular; D005656:Fungal Proteins / Q000737:chemistry / Q000235:genetics; D008969:Molecular Sequence Data; D027501:Monocarboxylic Acid Transporters / Q000737:chemistry / Q000235:genetics*; D010802:Phylogeny; D027981:Symporters / Q000737:chemistry / Q000235:genetics*; D026801:Synteny
D005656:Fungal Proteins; D027501:Monocarboxylic Acid Transporters; D027981:Symporters