title: Association between genetic polymorphisms in the human interleukin-7 receptor alpha-chain and inhalation allergy.
abstract: Thymic stromal-derived lymphopoietin (TSLP) and interleukin-7 share a common receptor chain, IL-7Ralpha. IL-7 is involved in T-cell homeostasis, and TSLP induces production of pro-allergic cytokines. The gene encoding the IL-7Ralpha chain is polymorphic, and investigation of inhalation allergic patients compared with controls showed significant association with two alleles at position +1237 and +2087.
authors.affiliation: Tissue Typing Laboratory, Department of Clinical Immunology, Rigshospitalet, Denmark. zaiba_shamim@hotmail.com
authors.forename: Z
authors.initials: Z
authors.lastname: Shamim
authors.forename: K
authors.initials: K
authors.lastname: Müller
authors.forename: A
authors.initials: A
authors.lastname: Svejgaard
authors.forename: L K
authors.initials: LK
authors.lastname: Poulsen
authors.forename: U
authors.initials: U
authors.lastname: Bodtger
authors.forename: L P
authors.initials: LP
authors.lastname: Ryder
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D003718:Denmark / Q000453:epidemiology; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D020395:Receptors, Interleukin-7 / Q000235:genetics*; D012130:Respiratory Hypersensitivity / Q000453:epidemiology / Q000235:genetics*
chemical_list: D020395:Receptors, Interleukin-7; C415350:interleukin-7 receptor, alpha chain