title: Systemic mastocytosis in association with chronic lymphocytic leukemia: a rare diagnosis.
abstract: Systemic mastocytosis may be primary or be associated with other hematological malignancies, most commonly myeloid neoplasms. In contrast, the association of systemic mastocytosis with lymphoid neoplasms is comparatively rare, and in the absence of appropriate clinical vigilance the diagnosis may be missed. We report a case of aggressive systemic mastocytosis associated with chronic lymphocytic leukemia (SM-CLL), placing particular emphasis on the investigational algorithm used in establishing this diagnosis, and discussing key clinical considerations in the initiation of therapy.
authors.affiliation: Leukemia Department, University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030 USA.
authors.forename: Patricia
authors.initials: P
authors.lastname: Ault
authors.forename: Alice
authors.initials: A
authors.lastname: Lynn
authors.forename: Constantine S
authors.initials: CS
authors.lastname: Tam
authors.forename: L Jeffrey
authors.initials: LJ
authors.lastname: Medeiros
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Keating
mesh_terms: D001856:Bone Marrow Examination; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications* / Q000175:diagnosis; D008297:Male; D034721:Mastocytosis, Systemic / Q000150:complications* / Q000175:diagnosis; D008875:Middle Aged; D016609:Neoplasms, Second Primary