The anti-androgen effect of ganoderol B isolated from the fruiting body of Ganoderma lucidum.
The anti-androgenic activity of the ethanol extract of the fruiting body of Ganoderma lucidum has been previously reported. Ganoderol B with 5alpha-reductase inhibitory activity and the ability to bind to androgen receptor (AR) can inhibit androgen-induced LNCaP cell growth and suppress regrowth of the ventral prostate induced by testosterone in rats. The down-regulation of AR signaling by ganoderol B provides an important mechanism for its anti-androgenic activity. In view of the fact that PSA (prostatic specific antigen, a well-accepted prognostic indicator of prostate cancer) is down-regulated, an important implication of this study is that ganoderol B intervention strategy aimed at toning down the amplitude of androgen signaling could be helpful in controlling morbidity of prostate cancer. In conclusion, our result suggests that ganoderol B might be useful in prostate cancer and benign prostatic hyperplasia (BPH) therapy through suppressing the function of androgen and its receptor.
Liu
Jie
J
Department of Forest and Forest Products Science, Faculty of Agriculture, Kyushu University, Fukuoka 812-8581, Japan.
Shimizu
Kuniyoshi
K
Konishi
Fumiko
F
Kumamoto
Shoichiro
S
Kondo
Ryuichiro
R
D000726:Androgen Antagonists / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D000728:Androgens / Q000235:genetics / Q000378:metabolism; D000818:Animals; D045744:Cell Line, Tumor; D005786:Gene Expression Regulation / Q000187:drug effects; D006801:Humans; D008297:Male; D015394:Molecular Structure; D011467:Prostate / Q000187:drug effects / Q000254:growth & development; D017430:Prostate-Specific Antigen / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics; D051381:Rats; D020940:Reishi / Q000737:chemistry*; D013739:Testosterone / Q000494:pharmacology; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*
D000726:Androgen Antagonists; D000728:Androgens; D012333:RNA, Messenger; D014315:Triterpenes; C521787:ganoderol B; D013739:Testosterone; D017430:Prostate-Specific Antigen