title: [Preparation and antitussive, expectorant and antiasthmatic activities of verticinone-bile acids salts].
abstract: To search for potential drugs with potent antitussive, expectorant, antiasthmatic activities and low toxicity, a series of verticinone-bile acids salts were prepared based on the clearly elucidated antitussive, expectorant and antiasthmatic activities of verticinone in bulbs of Fritillaria and different bile acids in Snake Bile. The antitussive, expectorant and antiasthmatic activities of these verticinone-bile acid salts were then screened with different animal models. Ver-CA (verticinone-cholic acid salt) and Ver-CDCA (verticinone-chenodeoxycholic acid salt) showed much more potent activities than other compounds. The bioactivities of Ver-CA and Ver-CDCA are worthy to be intensively studied, and it is also deserved to pay much attention to their much more potent antitussive effects than codeine phosphate. In order to elucidate whether they have synergistic effect and attenuated toxicity, their activities will be continuously compared with single verticinone, cholic acid and chenodeoxycholic acid at the same doses on different animal models. The application of "combination principles" in traditional Chinese medicinal formulations may be a novel way in triditional Chinese medicine research and discovery.
authors.affiliation: Faculty of Pharmaceutical Sciences, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430030, China.
authors.forename: Fang-Zhou
authors.initials: FZ
authors.lastname: Xu
authors.forename: Yong-Hui
authors.initials: YH
authors.lastname: Zhang
authors.forename: Han-Li
authors.initials: HL
authors.lastname: Ruan
authors.forename: Hui-Fang
authors.initials: HF
authors.lastname: Pi
authors.forename: Chang
authors.initials: C
authors.lastname: Chen
authors.forename: Ji-Zhou
authors.initials: JZ
authors.lastname: Wu
mesh_terms: D000818:Animals; D018927:Anti-Asthmatic Agents / Q000737:chemistry / Q000494:pharmacology*; D000996:Antitussive Agents / Q000737:chemistry / Q000494:pharmacology*; D001249:Asthma / Q000517:prevention & control; D001647:Bile Acids and Salts / Q000737:chemistry / Q000494:pharmacology*; D002595:Cevanes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002635:Chenodeoxycholic Acid / Q000737:chemistry / Q000494:pharmacology; D019826:Cholic Acid / Q000737:chemistry / Q000494:pharmacology; D003371:Cough / Q000517:prevention & control; D004338:Drug Combinations; D004339:Drug Compounding / Q000379:methods; D004357:Drug Synergism; D005100:Expectorants / Q000737:chemistry / Q000494:pharmacology*; D005260:Female; D031410:Fritillaria / Q000737:chemistry; D006168:Guinea Pigs; D008297:Male; D051379:Mice; D010946:Plants, Medicinal / Q000737:chemistry; D011897:Random Allocation; D012911:Snakes
chemical_list: D018927:Anti-Asthmatic Agents; D000996:Antitussive Agents; D001647:Bile Acids and Salts; D002595:Cevanes; D004338:Drug Combinations; D005100:Expectorants; D002635:Chenodeoxycholic Acid; C014242:verticine; D019826:Cholic Acid