title: Extended gene map reveals tripartite motif, C-type lectin, and Ig superfamily type genes within a subregion of the chicken MHC-B affecting infectious disease.
abstract: MHC haplotypes have a remarkable influence on whether tumors form following infection of chickens with oncogenic Marek's disease herpesvirus. Although resistance to tumor formation has been mapped to a subregion of the chicken MHC-B region, the gene or genes responsible have not been identified. A full gene map of the subregion has been lacking. We have expanded the MHC-B region gene map beyond the 92-kb core previously reported for another haplotype revealing the presence of 46 genes within 242 kb in the Red Jungle Fowl haplotype. Even though MHC-B is structured differently, many of the newly revealed genes are related to loci typical of the MHC in other species. Other MHC-B loci are homologs of genes found within MHC paralogous regions (regions thought to be derived from ancient duplications of a primordial immune defense complex where genes have undergone differential silencing over evolutionary time) on other chromosomes. Still others are similar to genes that define the NK complex in mammals. Many of the newly mapped genes display allelic variability and fall within the MHC-B subregion previously shown to affect the formation of Marek's disease tumors and hence are candidates for genes conferring resistance.
authors.affiliation: Division of Basic Medical Science and Molecular Medicine, Department of Molecular Life Science, Tokai University School of Medicine, Kanagawa, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Shiina
authors.forename: W Elwood
authors.initials: WE
authors.lastname: Briles
authors.forename: Ronald M
authors.initials: RM
authors.lastname: Goto
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Hosomichi
authors.forename: Kazuyo
authors.initials: K
authors.lastname: Yanagiya
authors.forename: Sayoko
authors.initials: S
authors.lastname: Shimizu
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Inoko
authors.forename: Marcia M
authors.initials: MM
authors.lastname: Miller
mesh_terms: D020816:Amino Acid Motifs / Q000235:genetics; D000818:Animals; D002645:Chickens / Q000235:genetics / Q000276:immunology*; D002874:Chromosome Mapping; D019143:Evolution, Molecular; D005805:Genes, MHC Class I; D014644:Genetic Variation; D006239:Haplotypes; D006801:Humans; D007113:Immunity, Innate / Q000235:genetics*; D007136:Immunoglobulins / Q000235:genetics*; D037181:Lectins, C-Type / Q000235:genetics*; D008380:Marek Disease / Q000235:genetics / Q000276:immunology*; D008969:Molecular Sequence Data; D005810:Multigene Family
chemical_list: D007136:Immunoglobulins; D037181:Lectins, C-Type