The "in vitro" antifungal activity evaluation of propolis G12 ethanol extract on Cryptococcus neoformans.
Cryptococcosis is a worldwide disease caused by the etiological agent Cryptococcus neoformans. It affects mainly immunocompromised humans. It is relatively rare in animals only affecting those that have received prolonged antibiotic therapy. The propolis is a resin that can present several biological properties, including antibacterial, antifungal and antiviral activities. The standard strain C. neoformans ATTC 90112 was used to the antifungal evaluation. The tests were realized with propolis ethanol extract (PEE) G12 in concentrations from 0.1 to 1.6 mg mL-1. The evaluation of MIC and MFC were done according to DUARTE (2002)5. The inhibitory effect of PEE G12 on the fungal growing was seen at the concentration of 0.2 mg mL-1 and 1.6 mg mL-1 was considered a fungicidal one.
Fernandes
Fabrício Freitas
FF
Departamento de Ciências Biológicas, Universidade Federal de Alfenas, Alfenas, MG, Brazil.
Dias
Amanda Latercia Tranches
AL
Ramos
Cíntia Lacerda
CL
Ikegaki
Masaharu
M
de Siqueira
Antonio Martins
AM
Franco
Marília Caixeta
MC
D000935:Antifungal Agents / Q000302:isolation & purification / Q000494:pharmacology*; D003455:Cryptococcus neoformans / Q000187:drug effects*; D000431:Ethanol / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D011429:Propolis / Q000494:pharmacology*
D000935:Antifungal Agents; D000431:Ethanol; D011429:Propolis