title: Mast cell density in gastric biopsies of pediatric age group and its relation to inflammation and presence of Helicobacter pylori.
abstract: BACKGROUND
  The aim of this study was to investigate the relationship between mast cell density, histological severity of gastritis, and presence of Helicobacter pylori (H. pylori) in the antral mucosa of pediatric patients.
  
  
  METHODS
  The study included 352 (192 male and 160 female, < 14 years old) patients. All cases underwent endoscopy, and biopsies were obtained for histopathological examination and evaluation of Helicobacter pylori. All biopsies were evaluated according to the Sydney system and mast cell density in the antral mucosa was analyzed by Giemsa stain. Spearman's correlation test was used to determine the relationship between mast cell density and other histopathological parameters. The comparison of mast cell density between H. pylori positive and negative groups was analyzed by Mann Whitney U test.
  
  
  RESULTS
  Mast cell density was 12.6 +/- 0.87 in 0.25 mm2 (0-81). Means of severity of gastric inflammation in H. pylori-positive and negative patients were 1.7 +/- 0.6 and 0.6 +/- 0.7, respectively, which was statistically significant (p = 0.0001). Mast cell density was not correlated with presence and degree of inflammation, activity, presence and score of H. pylori in the antrum (p > 0.05). There was no significant correlation between mast cell density and allergy.
  
  
  CONCLUSIONS
  We concluded that there may be some other ways for contribution of mast cells in pathologic processes involving gastrointestinal tract in children.
authors.affiliation: Pathology Department, Children Medical Center, Tehran University of Medical Sciences (TUMS), Tehran, Iran. fmahjoub@sina.tums.ac.ir
authors.forename: Fatemeh E
authors.initials: FE
authors.lastname: Mahjoub
authors.forename: Behnam
authors.initials: B
authors.lastname: Hassanbeglou
authors.forename: Zahra
authors.initials: Z
authors.lastname: Pourpak
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Farahmand
authors.forename: Nasim
authors.initials: N
authors.lastname: Kashef
authors.forename: Atousa Azam
authors.initials: AA
authors.lastname: Akhlaghi