Synthesis and cytotoxic evaluation of substituted urea derivatives as inhibitors of human-leukemia K562 cells.
A series of substituted urea derivatives, compounds 1-14, were synthesized and evaluated for their cytotoxic activities against the human-leukemia K562 cell line. Two structurally simple compounds, 7 and 12, both incorporating a morpholine ring, were found to be highly active, with IC50 values of ca. 0.25 microM.
Cao
Ping
P
Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, PR China.
Huang
Xian-Feng
XF
Ding
Hui
H
Ge
Hui-Ming
HM
Li
Huan-Qiu
HQ
Ruan
Ban-Feng
BF
Zhu
Hai-Liang
HL
D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D006801:Humans; D020014:K562 Cells; D007938:Leukemia / Q000473:pathology*; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D014508:Urea / Q000737:chemistry / Q000494:pharmacology*
D000970:Antineoplastic Agents; D014508:Urea