Neurotrophins and schizophrenia.
Neurotrophins have established roles in neuronal development, synaptogenesis, and response to stress/anxious stimuli. Moreover, these agents are neuromodulators of monoaminergic, GABAergic, and cholinergic systems. Amidst a growing appreciation of the developmental neurobiology of schizophrenia--as well as the propensity for progressive brain changes--there is emergent information on abnormalities in the expression of neurotrophins in schizophrenia. This article reviews the literature on neurotrophins and schizophrenia. A schema for understanding the neurobiology of relapse in schizophrenia is offered.
Buckley
Peter F
PF
Department of Psychiatry and Health Behavior, Medical College of Georgia, 1515 Pope Avenue, Augusta, Georgia 30912, United States. pbuckley@mail.mcg.edu
Mahadik
Sahebarao
S
Pillai
Anilkumar
A
Terry
Alvin
A
D014150:Antipsychotic Agents / Q000494:pharmacology / Q000627:therapeutic use; D001665:Binding Sites; D001921:Brain / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology; D019208:Brain-Derived Neurotrophic Factor / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D009414:Nerve Growth Factors / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D020813:Receptor, trkB / Q000187:drug effects / Q000378:metabolism; D012008:Recurrence; D012559:Schizophrenia / Q000188:drug therapy / Q000378:metabolism* / Q000503:physiopathology; D042461:Vascular Endothelial Growth Factor A / Q000187:drug effects / Q000378:metabolism
D014150:Antipsychotic Agents; D019208:Brain-Derived Neurotrophic Factor; D009414:Nerve Growth Factors; D042461:Vascular Endothelial Growth Factor A; D020813:Receptor, trkB