title: [Endoscopic therapy for gastroesophageal reflux disease].
abstract: A variety of endoscopic techniques for the treatment of gastroesophageal reflux disease (GERD) have been developed as alternatives to PPI therapy or antireflux surgery. These techniques include the delivery of radiofrequency energy to the gastroesophageal junction, injection of agents into the lower esophageal sphincter zone, and suture plication of the proximal fundic folds. Each of these endoscopic techniques is designed to alter the anatomy or physiology of the gastroesophageal junction to decrease gastroesophageal reflux. However, only limited data are available on the mechanism of action of the various endoscopic techniques. Most studies of endoscopic therapy have only limited follow-up information, and safety issues remain unresolved. Further sham-controlled clinical trials will be required for endoscopic device and technique.
authors.affiliation: Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine.
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Suzuki
authors.forename: Eisuke
authors.initials: E
authors.lastname: Iwasaki
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Hibi
mesh_terms: D017115:Catheter Ablation / Q000379:methods*; D016099:Endoscopy, Gastrointestinal / Q000379:methods*; D049630:Esophageal Sphincter, Lower / Q000601:surgery; D005764:Gastroesophageal Reflux / Q000628:therapy*; D011145:Polyvinyls / Q000008:administration & dosage; D013536:Suture Techniques
chemical_list: D011145:Polyvinyls; C020320:ethylene-vinyl alcohol copolymer