title: Cognitive reserve and neuropsychological functioning in patients infected with hepatitis C.
abstract: This study evaluated the influence of cognitive reserve on neuropsychological test performance in 198 patients infected with the hepatitis C virus. IQ scores, educational level, and occupational rating were combined to calculate a Cognitive Reserve Score (CRS) for each patient. Similar to studies of infection with the human immunodeficiency virus, there was a significantly increased risk of impairment in neuropsychological test performance in individuals with lower CRSs. It is important to account for CRS when assessing cognitive findings in large-scale clinical trials.
authors.affiliation: Neuropsychology Section, Department of Psychiatry, University of Michigan Medical Center, Ann Arbor, Michigan 48105, USA. linas@umich.edu
authors.forename: Linas A
authors.initials: LA
authors.lastname: Bieliauskas
authors.forename: Carla
authors.initials: C
authors.lastname: Back-Madruga
authors.forename: Karen L
authors.initials: KL
authors.lastname: Lindsay
authors.forename: Elizabeth C
authors.initials: EC
authors.lastname: Wright
authors.forename: Ziad
authors.initials: Z
authors.lastname: Kronfol
authors.forename: Anna S F
authors.initials: AS
authors.lastname: Lok
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Fontana
mesh_terms: D000328:Adult; D016009:Chi-Square Distribution; D003071:Cognition / Q000502:physiology*; D003072:Cognition Disorders / Q000453:epidemiology / Q000209:etiology* / Q000821:virology; D004522:Educational Status; D004651:Employment; D005260:Female; D005500:Follow-Up Studies; D006526:Hepatitis C / Q000150:complications* / Q000453:epidemiology; D006801:Humans; D007360:Intelligence; D008297:Male; D008606:Mental Processes; D008875:Middle Aged; D009048:Motor Skills; D009483:Neuropsychological Tests; D010555:Personality Inventory; D011340:Problem Solving; D012306:Risk