title: Metastasis in para-aortic lymph nodes in patients with advanced gastric cancer, treated with extended lymphadenectomy.
abstract: OBJECTIVE
  Lymph node dissection is an essential component of curative resection for advanced gastric cancer. To improve the survival of N2 patients, Asian surgeons have been performing D2+para-aortic lymph node dissection. The current study presents the results of lymph node status from multicenter trial of D2 and D2 + para-aortic nodal (No.16) dissection (D4 dissection).
  
  
  METHODS
  Patients enrolled in the study had potentially curable gastric adenocarcinoma in an advanced stage, T2, T3 or T4/N1 or N2. Patients were randomized to undergo either D2 or D4 gastrectomy.
  
  
  RESULTS
  Two hundred and seventy patients were registered and 136 and 134 patients were allocated into the D2 or D4 group, respectively. The average nodal yield of No.16 in D4 group was 18.4 +/- 14.1, ranging from 2 to 84. No.16 metastasis was detected in 12 (9.0%) of 134 D4 patients. One, 9 and 2 patients had simultaneous involvement in N1, N2, and N3 (No.8p, 12, 13 or 14). Namely, in 39 patients who were diagnosed as N2 from the lymph node status in N1 and N2 levels, nine (23.0%) patients had No.16 metastasis. The stage migration by D4 was found in 10 (7.5%). Logistic regression analysis revealed that the stations of No.7 and No.8 were the significant predictors of No.16 involvement.
  
  
  CONCLUSIONS
  The present study may strongly suggest that prophylactic D4 dissection may be indicated for patients with N2 involvement, and that No.7 and No.8 are the junctional nodes for D4 dissection.
authors.affiliation: Shizuoka Cancer Center, Shizuoka, Japan. y.yonemura@scchr.jp
authors.forename: Y
authors.initials: Y
authors.lastname: Yonemura
authors.forename: C C
authors.initials: CC
authors.lastname: Wu
authors.forename: N
authors.initials: N
authors.lastname: Fukushima
authors.forename: I
authors.initials: I
authors.lastname: Honda
authors.forename: E
authors.initials: E
authors.lastname: Bandou
authors.forename: T
authors.initials: T
authors.lastname: Kawamura
authors.forename: S
authors.initials: S
authors.lastname: Kamata
authors.forename: H
authors.initials: H
authors.lastname: Yamamoto
authors.forename: B S
authors.initials: BS
authors.lastname: Kim
authors.forename: N
authors.initials: N
authors.lastname: Matsuki
authors.forename: T
authors.initials: T
authors.lastname: Sawa
authors.forename: S H
authors.initials: SH
authors.lastname: Noh
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality / Q000473:pathology* / Q000601:surgery*; D000368:Aged; D001012:Aorta, Abdominal; D005260:Female; D005743:Gastrectomy / Q000379:methods*; D006801:Humans; D008197:Lymph Node Excision / Q000379:methods*; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis / Q000473:pathology*; D008297:Male; D009367:Neoplasm Staging; D011379:Prognosis; D013274:Stomach Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery*