title: [Progression in diagnostic pathology; development of virtual microscopy and its applications].
abstract: Many systems have already been designed and successfully used for clinical laboratory and pathological examination. The evolution of image analysis was enabled when analog images of the original glass slides could be transferred to digital images with the rapid development of virtual microscopy and virtual slides depended upon computer technologies. Today, whole slide can be acquired by virtual microscopes. The applications of virtual microscopy and virtual slides for teaching, diagnosis, telepathology, and research are more widely used than those of real microscope and real glass slides. In traditional cancer diagnosis, pathologists examine biopsies to make diagnostic assessments largely based on two-dimensional cell morphology and tissue distribution. These assessments are subjective and often show considerable variability. However, automated cancer diagnostic system based on three-dimensional image analysis based on nuclear bulging sign enables objective judgments using quantitative measurements. We expect that the shortage of pathologists will be improved when an automated cancer diagnosis system is developed.
authors.affiliation: Department of Medical Technology, Hirosaki University School of Health Sciences, Hirosaki 036-8564.
authors.forename: Tatsusuke
authors.initials: T
authors.lastname: Sato
authors.forename: Tomisato
authors.initials: T
authors.lastname: Miura
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Nozaka
authors.forename: Yosei
authors.initials: Y
authors.lastname: Katayama
authors.forename: Akira
authors.initials: A
authors.lastname: Moriuchi
authors.forename: Shinichi
authors.initials: S
authors.lastname: Nakamura
authors.forename: Zhongxi
authors.initials: Z
authors.lastname: Zheng
authors.forename: Terumasa
authors.initials: T
authors.lastname: Takamatsu
mesh_terms: D001331:Automation; D006652:Histological Techniques; D006801:Humans; D008853:Microscopy / Q000379:methods*; D009369:Neoplasms / Q000175:diagnosis; D014584:User-Computer Interface