"Wunder" F-BAR domains: going from pits to vesicles.
Clathrin-mediated endocytosis is a key mechanism by which cells take up extracellular cargo. In this issue, Shimada et al. (2007) reveal the mode of action of the F-BAR domain, which deepens the initial membrane pit that forms during clathrin-mediated endocytosis.
Fütterer
Klaus
K
School of Biosciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK. k.futterer@bham.ac.uk
Machesky
Laura M
LM
D000818:Animals; D002966:Clathrin / Q000737:chemistry / Q000378:metabolism*; D022163:Clathrin-Coated Vesicles / Q000378:metabolism* / Q000648:ultrastructure; D003034:Coated Pits, Cell-Membrane / Q000378:metabolism* / Q000648:ultrastructure; D004705:Endocytosis / Q000502:physiology*; D006801:Humans; D008024:Ligands; D008565:Membrane Proteins / Q000378:metabolism; D008958:Models, Molecular; D017434:Protein Structure, Tertiary / Q000502:physiology; D011956:Receptors, Cell Surface / Q000378:metabolism / Q000648:ultrastructure
D002966:Clathrin; D008024:Ligands; D008565:Membrane Proteins; D011956:Receptors, Cell Surface