title: A major triterpenoid saponin from Gypsophila oldhamiana.
abstract: A new saponin, gypoldoside A (1), was isolated from the roots of Gypsophila oldhamiana. On the basis of in-depth NMR-spectroscopic and mass-spectrometric analysis, in combination with chemical evidence, its structure was established as 3-O-{beta-D-galactopyranosyl-(1-->2)-[beta-D-xylopyranosyl-(1-->3)]-beta-D-glucuronopyranosyl}quillaic acid 28-[alpha-L-arabinopyranosyl-(1-->2)-alpha-L-arabinopyranosyl-(1-->3)-beta-D-xylopyranosyl-(1-->4)-alpha-L-rhamnopyranosyl-(1-->2)-beta-D-fucopyranosyl] ester. Compound 1 was found to be highly active against three different human cancer cell lines, with IC50 values in the low micromolar range.
authors.affiliation: Institute of Materia Medica, Shandong Academy of Medical Sciences, Jinan 250062, Shandong, PR China.
authors.forename: Hong
authors.initials: H
authors.lastname: Bai
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhong
authors.forename: Yan-Ying
authors.initials: YY
authors.lastname: Xie
authors.forename: Yuan-Shu
authors.initials: YS
authors.lastname: Wang
authors.forename: Lu
authors.initials: L
authors.lastname: Liu
authors.forename: Ling
authors.initials: L
authors.lastname: Zhou
authors.forename: Ju
authors.initials: J
authors.lastname: Wang
authors.forename: Yan-Ling
authors.initials: YL
authors.lastname: Mu
authors.forename: Chun-Xu
authors.initials: CX
authors.lastname: Zuo
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D029748:Caryophyllaceae / Q000737:chemistry*; D045744:Cell Line, Tumor; D006801:Humans; D020128:Inhibitory Concentration 50; D018517:Plant Roots / Q000737:chemistry*; D012503:Saponins / Q000494:pharmacology*
chemical_list: C520752:3-O-(galactopyranosyl-1-2-(xylopyranosyl-1-3-)glucuronosyl)quillaic acid 28-(arabinopyranosyl-1-2-arabinopyranosyl-1-3-xylopyranosyl-1-4-rhamnopyranosyl-1-2-fucopyranosyl) ester; D000970:Antineoplastic Agents; D012503:Saponins