[Use of acetylcysteine and polyoxydonium for the correction of immune homeostasis and antioxidant system impaired by combined action of 1,2-dichloroethane and heavy mechanical trauma].
The experiments on noninbred rats showed that a combination of heavy mechanical trauma and 1,2-dichloroethane in a single dose of 0.5 LD50 leads to summation of the immunosuppressive and prooxidizing effects of both factors. A combined administration of acetylcysteine and polyoxidonium on the background of the combined action of a heavy mechanical trauma and 1, 2-dichloroethane (1.5 LD50) reduces the suppression of immune responses and the activation of lipid peroxidation caused by these factors.
Zabrodskiĭ
P F
PF
Kirichuk
V F
VF
Ivanov
D Iu
DIu
Mandych
V G
VG
D000111:Acetylcysteine / Q000627:therapeutic use*; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D000975:Antioxidants / Q000378:metabolism*; D005025:Ethylene Dichlorides / Q000633:toxicity*; D005260:Female; D016166:Free Radical Scavengers / Q000627:therapeutic use; D006706:Homeostasis; D007111:Immunity, Cellular / Q000187:drug effects; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D009930:Organic Chemicals / Q000627:therapeutic use; D010084:Oxidation-Reduction; D051381:Rats; D012774:Shock, Traumatic / Q000276:immunology*
D000975:Antioxidants; D005025:Ethylene Dichlorides; D016166:Free Radical Scavengers; D009930:Organic Chemicals; C089921:polyoxydonium; D000111:Acetylcysteine