title: Fixed and autoadjusting continuous positive airway pressure treatments are not similar in reducing cardiovascular risk factors in patients with obstructive sleep apnea.
abstract: BACKGROUND
  A strong association between obstructive sleep apnea (OSA) and the risk for cardiovascular and cerebrovascular diseases has been reported. Continuous positive airway pressure (CPAP) is the first-line therapy for OSA, able not only to reduce daytime sleepiness but also to improve cardiovascular and metabolic outcomes. Autoadjusting CPAP (APAP), an alternative treatment to CPAP, can reduce OSA symptoms while increasing long-term CPAP compliance without the high costs of CPAP titration. However, no data are available on the effects of APAP on cardiovascular risk factors
  
  
  METHODS
  We performed standard full polysomnography; obtained plasma levels of glucose, insulin, and C-reactive protein (CRP); and measured systolic BP (SBP) and diastolic BP (DBP) in 31 patients with newly diagnosed, severe OSA. After standard CPAP titration, all subjects were randomized to CPAP or APAP treatment. Measurements were obtained at baseline and after 3 months of treatment.
  
  
  RESULTS
  The two groups were similar in terms of age, sex, body mass index (BMI), and severity of OSA. SBP, DBP, heart rate (HR), homeostasis model assessment index (HOMA-IR), and CRP were similar in the two groups. After 3 months of treatment, BMI, HR, and compliance to therapy were also comparable. OSA indexes were significantly reduced in both groups. Significant reductions in SBP, DBP, and HOMA-IR were observed in the CPAP group but not in the APAP group, while CRP plasma levels were similarly reduced.
  
  
  CONCLUSIONS
  Our results suggest that CPAP and APAP, despite significant effects on OSA indexes and symptoms, do not improve cardiovascular risk factors in the same fashion.
authors.affiliation: Department of Respiratory Rehabilitation, S. Marta Hospital, Rivoli d'Adda, Ospedale Maggiore, Crema, Italy.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Patruno
authors.forename: Stefano
authors.initials: S
authors.lastname: Aiolfi
authors.forename: Giorgio
authors.initials: G
authors.lastname: Costantino
authors.forename: Rodolfo
authors.initials: R
authors.lastname: Murgia
authors.forename: Carlo
authors.initials: C
authors.lastname: Selmi
authors.forename: Alberto
authors.initials: A
authors.lastname: Malliani
authors.forename: Nicola
authors.initials: N
authors.lastname: Montano
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000502:physiology; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000150:complications* / Q000503:physiopathology / Q000517:prevention & control*; D045422:Continuous Positive Airway Pressure / Q000379:methods*; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D007249:Inflammation / Q000503:physiopathology / Q000517:prevention & control; D007333:Insulin Resistance / Q000502:physiology; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D020181:Sleep Apnea, Obstructive / Q000150:complications* / Q000503:physiopathology / Q000628:therapy*; D013997:Time Factors
chemical_list: D001786:Blood Glucose; D002097:C-Reactive Protein