title: Transcranial and deep brain stimulation approaches as treatment for depression.
abstract: Given that a considerable portion of depressed patients does not respond to or remit during pharmacotherapy, there is increasing interest in non-pharmacological strategies to treat depressive disorders. Several brain stimulation approaches are currently being investigated as novel therapeutic interventions beside electroconvulsive therapy (ECT), a prototypic method in this field with proven effectiveness. These neurostimulation methods include repetitive transcranial magnetic stimulation (rTMS), magnetic seizure therapy (MST), vagus nerve stimulation (VNS), deep brain stimulation (DBS) and transcranial direct current stimulation (tDCS). It is via different neuroanatomically defined "windows" that the various approaches access the neuronal networks showing an altered function in depression. Also, the methods vary regarding their degree of invasiveness. One or the other method may finally achieve antidepressant effectiveness with minimized side effects and constitute a new effective treatment for major depression.
authors.affiliation: Dept. of Psychiatry and Psychotherapy, Ludwig-Maximilians University Munich, Munich, Germany.
authors.forename: Anne
authors.initials: A
authors.lastname: Rau
authors.forename: Nicola
authors.initials: N
authors.lastname: Grossheinrich
authors.forename: Ulrich
authors.initials: U
authors.lastname: Palm
authors.forename: Oliver
authors.initials: O
authors.lastname: Pogarell
authors.forename: Frank
authors.initials: F
authors.lastname: Padberg
mesh_terms: D002986:Clinical Trials as Topic / Q000639:trends; D046690:Deep Brain Stimulation / Q000295:instrumentation* / Q000379:methods* / Q000639:trends; D003863:Depression / Q000628:therapy*; D004867:Equipment Design; D006801:Humans; D010818:Practice Patterns, Physicians' / Q000639:trends; D050781:Transcranial Magnetic Stimulation / Q000295:instrumentation* / Q000379:methods* / Q000639:trends; D016896:Treatment Outcome