title: Aortocoronary bypass grafting in high-risk patients over 75 years. Propensity score analysis of on versus off-pump, early and midterm results.
abstract: OBJECTIVE
  Bypass surgery in high risk patients over the age of 75 results in increased mortality and morbidity, which may be also related to the cardiopulmonary bypass system.
  
  
  METHODS
  Using the propensity score analysis, we have selected two homogeneous groups of high-risk elderly patients undergoing coronary surgery: 41 patients operated with cardiopulmonary bypass- coronary artery bypass graft (CPB-CABG), and 78 patients operated without cardiopulmonary bypass (off-pump coronary artery bypass graft, OPCABG). All preoperative and operative variables were similar and outcomes were compared.
  
  
  RESULTS
  Perioperative mortality was higher in the patient group operated with CPB (12.2%) as compared to patients operated without CPB (1.3%, P = 0.01). Perioperative complications were more frequent in the CPB-CABG group. Logistic regression analysis showed that avoiding CPB was an independent protective factor for mortality and morbidity. Midterm survival, freedom from angina, freedom from reintervention, and Canadian Cardiovascular Society (CSS) class were comparable between the 2 groups.
  
  
  CONCLUSIONS
  OPCABG is safe in the high risk elderly population and significantly reduces postoperative mortality and morbidity. There are no differences in midterm results between the 2 groups of patients in our study.
authors.affiliation: Cardiothoracic Surgery Department, Sant'Ambrogio Hospital, Milan, Italy. massimo.meco@virgilio.it
authors.forename: M
authors.initials: M
authors.lastname: Meco
authors.forename: T
authors.initials: T
authors.lastname: Biraghi
authors.forename: P
authors.initials: P
authors.lastname: Panisi
authors.forename: F
authors.initials: F
authors.lastname: Casselman
authors.forename: D
authors.initials: D
authors.lastname: Cosseta
authors.forename: S
authors.initials: S
authors.lastname: Cirri
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000787:Angina Pectoris / Q000209:etiology / Q000517:prevention & control*; D001281:Atrial Fibrillation / Q000209:etiology; D016063:Blood Loss, Surgical; D002303:Cardiac Output, Low / Q000209:etiology; D001026:Coronary Artery Bypass / Q000009:adverse effects*; D047549:Coronary Artery Bypass, Off-Pump / Q000009:adverse effects*; D003324:Coronary Artery Disease / Q000150:complications / Q000401:mortality / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D017052:Hospital Mortality; D006801:Humans; D053208:Kaplan-Meier Estimate; D016015:Logistic Models; D008297:Male; D009203:Myocardial Infarction / Q000209:etiology; D009422:Nervous System Diseases / Q000209:etiology; D051437:Renal Insufficiency / Q000209:etiology; D012131:Respiratory Insufficiency / Q000209:etiology; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D012720:Severity of Illness Index; D013997:Time Factors; D016896:Treatment Outcome