title: Basic autonomic nervous function in patients with neurocardiogenic syncope.
abstract: Basic autonomic nervous function was evaluated in patients with neurocardiogenic syncope (NCS). Atropine, isoproterenol, propranolol, phenylephrine, and phentolamine were administered successively, and parasympathetic nerve activity and beta- (and alpha-) activity, sensitivity, and secretion of the sympathetic nerve were determined in patients with NCS and control subjects. In patients with NCS, beta- and alpha- sensitivity were higher and beta-activity and beta- and alpha-secretion lower than in control subjects. In patients with NCS, the increased basic beta-sensitivity may contribute to induce strong cardiac contractions and augment ventricular mechanoreceptor response, and a compensatory state against diminished neuronal sympathetic activity is suggested by the increased alpha-sensitivity.
authors.affiliation: Department of Cardiology, Surugadai Nihon University Hospital, Tokyo, Japan. fsaito@med.nihon-u.ac.jp
authors.forename: Fumio
authors.initials: F
authors.lastname: Saito
authors.forename: Shinobu
authors.initials: S
authors.lastname: Imai
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Tanaka
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Tanaka
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Suzuki
authors.forename: Hidehito
authors.initials: H
authors.lastname: Takase
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Aoyama
authors.forename: Kagari
authors.initials: K
authors.lastname: Matsudaira
authors.forename: Tomonori
authors.initials: T
authors.lastname: Ebuchi
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Akamine
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Takahashi
authors.forename: Keiichi
authors.initials: K
authors.lastname: Sugino
authors.forename: Katsuo
authors.initials: K
authors.lastname: Kanmatsuse
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yagi
authors.forename: Toshio
authors.initials: T
authors.lastname: Kushiro
mesh_terms: D000293:Adolescent; D000316:Adrenergic alpha-Agonists / Q000008:administration & dosage; D000317:Adrenergic alpha-Antagonists / Q000008:administration & dosage; D000318:Adrenergic beta-Agonists / Q000008:administration & dosage; D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage; D000328:Adult; D001285:Atropine / Q000008:administration & dosage; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D005260:Female; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D006801:Humans; D007262:Infusions, Intravenous; D007545:Isoproterenol / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D010275:Parasympathetic Nervous System / Q000187:drug effects / Q000503:physiopathology*; D010276:Parasympatholytics / Q000008:administration & dosage; D010646:Phentolamine / Q000008:administration & dosage; D010656:Phenylephrine / Q000008:administration & dosage; D011433:Propranolol / Q000008:administration & dosage; D012720:Severity of Illness Index; D013564:Sympathetic Nervous System / Q000187:drug effects / Q000503:physiopathology*; D019462:Syncope, Vasovagal / Q000097:blood / Q000175:diagnosis / Q000503:physiopathology*
chemical_list: D000316:Adrenergic alpha-Agonists; D000317:Adrenergic alpha-Antagonists; D000318:Adrenergic beta-Agonists; D000319:Adrenergic beta-Antagonists; D010276:Parasympatholytics; D010656:Phenylephrine; D001285:Atropine; D011433:Propranolol; D007545:Isoproterenol; D010646:Phentolamine