Synthesis of alkylamides of dipeptides as potential plasmin inhibitors.
Four dipeptide alkylamides with general formula H-D-Phe-L-Lys-NH-X, where X = cyclohexyl, - (CH2)5NH2, -(CH2)2-OH and hexyl were obtained. Effect of these compounds on amidolytic and fibrinolytic activity of plasmin was examined.
Midura-Nowaczek
Krystyna
K
Department of Organic Chemistry, Medical University of Białystok, 1 Kilińskiego Str., 15-089 Białystok, Poland.
Lepietuszko
Izabela
I
Bruzgo
Irena
I
D000577:Amides / Q000138:chemical synthesis* / Q000494:pharmacology*; D004151:Dipeptides / Q000138:chemical synthesis* / Q000494:pharmacology*; D005341:Fibrinolysin / Q000037:antagonists & inhibitors*; D008239:Lysine / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D013329:Structure-Activity Relationship; D013917:Thrombin / Q000037:antagonists & inhibitors
D000577:Amides; D004151:Dipeptides; D013917:Thrombin; D005341:Fibrinolysin; D008239:Lysine