Evaluating dosage compensation as a cause of duplicate gene retention in Paramecium tetraurelia.
The high retention of duplicate genes in the genome of Paramecium tetraurelia has led to the hypothesis that most of the retained genes have persisted because of constraints due to gene dosage. This and other possible mechanisms are discussed in the light of expectations from population genetics and systems biology.
Hughes
Timothy
T
Computational Biology Unit, Bergen Center for Computational Science, University of Bergen, 5020 Bergen, Norway.
Ekman
Diana
D
Ardawatia
Himanshu
H
Elofsson
Arne
A
Liberles
David A
DA
D000818:Animals; D004303:Dosage Compensation, Genetic; D020440:Gene Duplication; D005828:Genetics, Population; D018503:Genome, Protozoan; D016805:Paramecium tetraurelia / Q000235:genetics*; D049490:Systems Biology