[Discovery strategy for effective and active constituents of Chinese material medica based on processes of metabolism and disposition in intra-body].
Chinese material medica is the natural therapeutic agent used under the guidance of the theories of traditional Chinese medicine. Its sources are mainly derive from plants, some derive from animals and minerals, and a few derive from chemical drugs and biologic products. It was made up into a colossal complexed system because it's diversity of biological sources, ecological environments, chemical structures, processing methods, processes of metabolism and disposition in intra-body, biological activity and clinical use, and involved a lot of scientific problems. The elucidation of the effective and active constituents is a basic and scientific problem to clarify complexed system of Chinese material medica. Along with research progressing of processes of metabolism and disposition of Chinese material medica in intra-body and metabonomics, a new and rapid-developing technology, the discovery strategy for effective and active constituents of Chinese material medica based on the processes of metabolism and disposition would be made up, which will provide a new methodology and pathway to clarify of complexed system of Chinese material medica.
Yang
Xiu-Wei
XW
School of Pharmaceutical Sciences, Peking University, Beijing 100083, China. xwyang@bjmu.edu.cn
D001711:Biotransformation; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D015195:Drug Design; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000378:metabolism / Q000493:pharmacokinetics; D006801:Humans; D008419:Materia Medica / Q000378:metabolism; D008516:Medicine, Chinese Traditional / Q000379:methods*; D010946:Plants, Medicinal / Q000737:chemistry* / Q000378:metabolism; D021281:Quantitative Structure-Activity Relationship; D014018:Tissue Distribution
D004365:Drugs, Chinese Herbal; D008419:Materia Medica; D003577:Cytochrome P-450 Enzyme System