title: Chemotherapy of leishmaniasis. Part VII: synthesis and bioevaluation of substituted terpenyl pyrimidines.
abstract: Some novel 4-N-substituted terpenyl pyrimidines 5(a-d) and 7(a-g) have been synthesized using novel synthetic methods. The compounds were screened for in vivo antileishmanial screening. When compared to 4-thiomethoxy substituted pyrimidine 2 4-N-substituted terpenyl pyrimidines 5(a-d) and 7(a-g) were found inactive.
authors.affiliation: Division of Medicinal Chemistry, Central Drug Research Institute, Chatter Manzil, Lucknow 226001, Uttar Pradesh, India. shivajins@yahoo.co.in
authors.forename: S N
authors.initials: SN
authors.lastname: Suryawanshi
authors.forename: B A
authors.initials: BA
authors.lastname: Bhat
authors.forename: Susmita
authors.initials: S
authors.lastname: Pandey
authors.forename: Naveen
authors.initials: N
authors.lastname: Chandra
authors.forename: Suman
authors.initials: S
authors.lastname: Gupta
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000627:therapeutic use*; D006224:Cricetinae; D004353:Drug Evaluation, Preclinical; D007896:Leishmaniasis / Q000188:drug therapy*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D013058:Mass Spectrometry; D008647:Mesocricetus; D011743:Pyrimidines / Q000627:therapeutic use*; D013055:Spectrophotometry, Infrared
chemical_list: D000981:Antiprotozoal Agents; D011743:Pyrimidines