[Paclitaxel-induced lupus].
BACKGROUND
Paclitaxel (Taxol) is a drug derived from the bark of the Pacific yew tree and is widely used in cancer treatment, especially for breast, ovarian, and lung cancers. It has not previously been reported to induce lupus.


METHODS
We report the case of a woman with ovarian cancer who developed paclitaxel-induced lupus on two occasions. Both times, the paclitaxel dramatically improved the ovarian cancer.


CONCLUSIONS
The diagnosis of lupus was confirmed by the initial skin appearance, elevated levels of antinuclear antibodies, recurrence on reintroduction, and biopsy results. To our knowledge, it is the first case reported of paclitaxel-induced lupus.
Lortholary
Alain
A
Service de chimiothérapie, Centre Catherine de Sienne, Nantes. lortholary.alain@catherinedesienne.fr
Cary-Ten Have Dallinga
Myriam
M
El Kouri
Claude
C
Morineau
Nadine
N
Ramée
Jean-François
JF
D000368:Aged; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000627:therapeutic use; D000974:Antibodies, Antinuclear / Q000032:analysis; D000972:Antineoplastic Agents, Phytogenic / Q000009:adverse effects* / Q000627:therapeutic use; D001623:Betamethasone / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000627:therapeutic use; D001706:Biopsy; D004359:Drug Therapy, Combination; D004921:Erythropoietin / Q000008:administration & dosage / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008178:Lupus Erythematosus, Cutaneous / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology / Q000473:pathology; D010051:Ovarian Neoplasms / Q000188:drug therapy; D017239:Paclitaxel / Q000009:adverse effects*; D011994:Recombinant Proteins; D012008:Recurrence; D012867:Skin / Q000473:pathology; D016896:Treatment Outcome
D000893:Anti-Inflammatory Agents; D000974:Antibodies, Antinuclear; D000972:Antineoplastic Agents, Phytogenic; D011994:Recombinant Proteins; C103998:epoetin beta; D004921:Erythropoietin; C011175:betamethasone-17,21-dipropionate; D001623:Betamethasone; D017239:Paclitaxel