title: [Early blastic transformation within a year of imatinib treatment in 2 cases of chronic myeloid leukemia].
abstract: We report herein on two rare cases of newly diagnosed chronic myeloid leukemia, which developed early blastic transformation within a year of imatinib treatment. Case 1 is a 22-year-old Japanese female, who underwent gradual blastic transformation with the increase of a resistant clone, which cytogenetically evolved right after she reached complete hematologic remission. Case 2 is a 24-year-old Japanese male, who underwent sudden transformation after 8 months treatment with imatinib mesylate following complete cytogenetic response. Although a sudden blastic transformation is extremely rare, the occurrence of such events even among the low-risk, good responding patients highlights the need for continued, rigorous monitoring by sensitive analysis, such as quantitative PCR. In order to accomplish the early eradication of minimal residual disease, the therapeutic strategy for chronic myeloid leukemia has to be defined in the era of imatinib, considering the application of allogeneic stem cell transplantation, which is currently the only curative treatment.
authors.affiliation: Department of Hematology, Kitasato University School of Medicine.
authors.forename: Koji
authors.initials: K
authors.lastname: Miyazaki
authors.forename: Shinya
authors.initials: S
authors.lastname: Kon
authors.forename: Takuro
authors.initials: T
authors.lastname: Watanabe
authors.forename: Tomiteru
authors.initials: T
authors.lastname: Togano
authors.forename: Manabu
authors.initials: M
authors.lastname: Ohsaka
authors.forename: Yuhko
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Mikio
authors.initials: M
authors.lastname: Danbara
authors.forename: Ryouichi
authors.initials: R
authors.lastname: Horie
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Kanda
authors.forename: Atsuo
authors.initials: A
authors.lastname: Maruta
authors.forename: Masaaki
authors.initials: M
authors.lastname: Higashihara
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000009:adverse effects*; D001549:Benzamides; D019008:Drug Resistance, Neoplasm; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D000068877:Imatinib Mesylate; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics / Q000473:pathology* / Q000628:therapy*; D008213:Lymphocyte Activation; D008297:Male; D008991:Monitoring, Physiologic; D010879:Piperazines / Q000008:administration & dosage* / Q000009:adverse effects*; D016133:Polymerase Chain Reaction; D011743:Pyrimidines / Q000008:administration & dosage* / Q000009:adverse effects*; D012074:Remission Induction
chemical_list: D000970:Antineoplastic Agents; D001549:Benzamides; D010879:Piperazines; D011743:Pyrimidines; D000068877:Imatinib Mesylate