Synthesis and antimicrobial studies of novel dichlorofluorophenyl containing aminotriazolothiadiazines.
Dichlorofluorophenyl containing aminotriazolothiadiazines (6) were synthesized by initial condensation of 2-chloro-N-(substituted phenyl) acetamides (4) with triazole (3) and further cyclization using POCl(3). The structures of newly synthesized compounds were confirmed by IR, NMR, mass and elemental analysis. All the compounds were screened for their antibacterial and antifungal activities. Compounds 5a, 5e, 5n, 5o, 6a, 6n, and 6o showed very good antibacterial and antifungal activities at 6.25 microg/ml concentrations.
Karthikeyan
Mari Sithambaram
MS
Department of Chemistry, Mangalore University, Mangalagangothri 574199, India. karthims02@rediffmail.com
Holla
Bantwal Shivarama
BS
Kumari
Nalilu Suchetha
NS
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013055:Spectrophotometry, Infrared; D013843:Thiazines / Q000138:chemical synthesis* / Q000494:pharmacology*; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D013843:Thiazines; D013844:Thiazoles