title: Novel epoxyfuranoid lignans and antitubercular constituents from the leaves of Beilschmiedia tsangii.
abstract: Three new epoxyfuranoid lignans, 4alpha,5alpha-epoxybeilschmin A (1), 4alpha,5alpha-epoxybeilschmin B (2), and beilschmin D (3), together with nine known compounds have been isolated from the leaves of Beilschmiedia tsangii. The structures of these new compounds were determined through spectral analyses. Among the isolates, beilschmin A (4) and beilschmin B (5) exhibited potent antitubercular activities (MICs = 2.5 and 7.5 microg/mL, respectively) against Mycobacterium tuberculosis 90 - 221387 in vitro.
authors.affiliation: Graduate Institute of Pharmaceutical Technology, Tajen University, Pingtung, Taiwan. jjchen@mail.tajen.edu.tw
authors.forename: Jih-Jung
authors.initials: JJ
authors.lastname: Chen
authors.forename: En-Tzu
authors.initials: ET
authors.lastname: Chou
authors.forename: Chien-Fang
authors.initials: CF
authors.lastname: Peng
authors.forename: Ih-Sheng
authors.initials: IS
authors.lastname: Chen
authors.forename: Sheng-Zehn
authors.initials: SZ
authors.lastname: Yang
authors.forename: Hung-Yi
authors.initials: HY
authors.lastname: Huang
mesh_terms: D000995:Antitubercular Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D019770:Lauraceae; D017705:Lignans / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves
chemical_list: D000995:Antitubercular Agents; D017705:Lignans; D010936:Plant Extracts