Neuroprotective effects of alpha2-adrenergic receptor agonists.
Alpha2-adrenergic receptor agonists exert potent analgesic and sedative/hypnotic effects. In addition, they have been shown to be neuroprotective in various experimental models, but the molecular pathways leading to these actions are still poorly defined. This review summarizes the available literature and discusses potential mechanisms of alpha2-adrenergic receptor agonist mediated neuroprotection.
Weber
Bernd
B
Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany. weber@anaesthesie.uni-kiel.de
Steinfath
Markus
M
Scholz
Jens
J
Bein
Berthold
B
D000322:Adrenergic Agonists / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000627:therapeutic use; D058647:Adrenergic alpha-2 Receptor Agonists; D000818:Animals; D006801:Humans; D048288:Imidazolines / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000627:therapeutic use; D018696:Neuroprotective Agents / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000627:therapeutic use
D000322:Adrenergic Agonists; D058647:Adrenergic alpha-2 Receptor Agonists; D048288:Imidazolines; D018696:Neuroprotective Agents