Unexpected steps in plasma-cell differentiation.
The transcriptional repressor Blimp-1 is considered the master regulator of plasma-cell differentiation. In this issue of Immunity, Kallies et al. (2007) identify a Blimp-1-independent stage of differentiation, followed by Blimp-1-dependent terminal differentiation.
Klein
Ulf
U
Institute for Cancer Genetics & Herbert Irving Comprehensive Cancer Center, Columbia University, 1130 St. Nicholas Avenue, New York, NY 10032, USA.
Dalla-Favera
Riccardo
R
D000818:Animals; D002454:Cell Differentiation / Q000276:immunology; D010950:Plasma Cells / Q000166:cytology* / Q000276:immunology / Q000378:metabolism; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
D012097:Repressor Proteins; D014157:Transcription Factors