Tumor necrosis factor-alpha and interleukin 6 in human periapical lesions.
OBJECTIVE
The aim of this study was to evaluate the presence of the cytokines tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) in human periapical lesions.


METHODS
Samples were obtained from three groups of teeth: symptomatic teeth, asymptomatic lesions, and uninflamed periradicular tissues as a control.


RESULTS
TNF-alpha levels were significantly increased in symptomatic lesions compared to control. Group with asymptomatic lesions had significantly higher concentrations compared to control. There were no significant differences in TNF-alpha levels between symptomatic and asymptomatic lesions. In group with symptomatic lesions, IL-6 levels were significantly higher than in group with asymptomatic lesions. The IL-6 levels in symptomatic group also showed significantly higher concentration in comparison with control group. In asymptomatic group, the IL-6 level had significantly higher concentrations compared to control.


CONCLUSIONS
These results indicate that symptomatic lesions represent an immunologically active stage of disease, and asymptomatic lesions are the point from which the process advances toward healing.
Prso
Ivana Brekalo
IB
Department of Dentistry, Medical Faculty, University of Rijeka, HR 51000 Rijeka, Croatia.
Kocjan
Willy
W
Simić
Hrvoje
H
Brumini
Gordana
G
Pezelj-Ribarić
Sonja
S
Borcić
Josipa
J
Ferreri
Silvio
S
Karlović
Ivana Miletić
IM
D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D015850:Interleukin-6 / Q000378:metabolism*; D010485:Periapical Periodontitis / Q000378:metabolism* / Q000473:pathology; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha