title: Clinical trials in gynecological cancer.
abstract: The Gynecologic Cancer Intergroup is comprised representatives from international gynecological cancer trials organizations, which collaborate in multicenter studies to answer the clinical challenges in gynecological cancer. This review article highlights the key clinical questions facing clinical trialists over the next decade, the information and infrastructure resources available for trials, and the methods of trial development. We cover human papillomavirus (HPV)-associated neoplasia, including cervical cancer, together with endometrial cancer, ovarian cancer, and vulvar cancer. Infrastructure for clinical trials includes a database for trials, templates for protocol development, patient educational material, and financial support for clinical trials. Other critical issues include support from government and charities and government regulations.
authors.affiliation: National Cancer Institute-Cancer Therapy Evaluation Program, Bethesda, MD, USA. trimblet@ctep.nci.nih.gov
authors.forename: E L
authors.initials: EL
authors.lastname: Trimble
authors.forename: J
authors.initials: J
authors.lastname: Davis
authors.forename: P
authors.initials: P
authors.lastname: Disaia
authors.forename: K
authors.initials: K
authors.lastname: Fujiwara
authors.forename: D
authors.initials: D
authors.lastname: Gaffney
authors.forename: G
authors.initials: G
authors.lastname: Kristensen
authors.forename: J
authors.initials: J
authors.lastname: Ledermann
authors.forename: J
authors.initials: J
authors.lastname: Pfisterer
authors.forename: M
authors.initials: M
authors.lastname: Quinn
authors.forename: N
authors.initials: N
authors.lastname: Reed
authors.forename: M
authors.initials: M
authors.lastname: Schoenfeldt
authors.forename: J T
authors.initials: JT
authors.lastname: Thigpen
mesh_terms: D002986:Clinical Trials as Topic / Q000191:economics / Q000295:instrumentation; D016889:Endometrial Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000628:therapy; D005260:Female; D005833:Genital Neoplasms, Female / Q000175:diagnosis / Q000473:pathology / Q000517:prevention & control / Q000628:therapy*; D006801:Humans; D009362:Neoplasm Metastasis; D010051:Ovarian Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000517:prevention & control / Q000628:therapy; D030361:Papillomavirus Infections / Q000150:complications; D014846:Vulvar Neoplasms / Q000628:therapy