A richness that cures.
A study in Nature by Fischer et al. shows that environmental enrichment or increasing histone acetylation rescue the ability to form new memories and re-establish access to remote memories even in the presence of brain degeneration. Chromatin remodeling may be the final gate environmental enrichment opens to enhance plasticity and represents a promising target for therapeutical intervention in neurodegenerative diseases.
Pizzorusso
Tommaso
T
Scuola Normale Superiore, Pisa, Italy.
Berardi
Nicoletta
N
Maffei
Lamberto
L
D000107:Acetylation; D000818:Animals; D001522:Behavior, Animal; D042002:Chromatin Assembly and Disassembly; D004777:Environment; D006657:Histones / Q000378:metabolism*; D008568:Memory / Q000502:physiology; D051379:Mice; D019636:Neurodegenerative Diseases / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy; D009473:Neuronal Plasticity
D006657:Histones