Functional and biological properties of the nuclear receptor coregulator PELP1/MNAR.
Proline-, glutamic acid-, and leucine-rich protein (PELP)1, also known as modulator of nongenomic actions of the estrogen receptor (MNAR), is a novel nuclear receptor coregulator with a multitude of functions. PELP1/MNAR serves as a scaffolding protein that couples various signaling complexes with nuclear receptors and participates in genomic and nongenomic functions. Recent data suggest that PELP1/MNAR expression is deregulated in several cancers, including breast, endometrial, prostate, and ovarian cancer, and that PELP1/MNAR interacts with several oncogenes. In this review, we summarize the emerging biological properties and functions of PELP1/MNAR.
Vadlamudi
Ratna K
RK
Department of Obstetrics and Gynecology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA. vadlamudi@uthscsa.edu
Kumar
Rakesh
R
D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism*; D056970:Co-Repressor Proteins; D006801:Humans; D008954:Models, Biological; D015398:Signal Transduction / Q000502:physiology*; D015534:Trans-Activators / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D014157:Transcription Factors
D056970:Co-Repressor Proteins; C438485:PELP1 protein, human; D015534:Trans-Activators; D014157:Transcription Factors