title: Risk factors for suicide completion in borderline personality disorder: a case-control study of cluster B comorbidity and impulsive aggression.
abstract: BACKGROUND
  Borderline personality disorder is a major risk factor for suicidal behavior, yet prediction of suicide completion remains unclear. It has been proposed that impulsivity and aggression interact to increase suicide risk. Death by suicide in borderline personality disorder, then, may be the result of impulsivity, a core feature of the disorder, interacting with violent-aggressive tendencies. Using a case-control design, this study investigated clinical and behavioral risk factors for suicide completion in borderline personality disorder.
  
  
  METHODS
  One hundred twenty subjects meeting DSM-IV criteria for borderline personality disorder, 50 controls and 70 who died by suicide between 2001 and 2005, were investigated by means of proxy-based interviews using structured diagnostic instruments and personality trait assessments.
  
  
  RESULTS
  Borderline personality disorder suicides had fewer psychiatric hospitalizations and suicide attempts than borderline personality disorder controls. Borderline personality disorder suicides were also more likely to meet criteria for current and lifetime substance dependence disorders. They had higher levels of current and lifetime Axis I comorbidity, novelty seeking, impulsivity, hostility, and comorbid personality disorders, while exhibiting lower levels of harm avoidance. Most importantly, borderline personality disorder suicides were more likely to have cluster B comorbidity. Impulsivity and aggression interacted to predict suicide, though not after controlling for cluster B comorbidity.
  
  
  CONCLUSIONS
  Borderline personality disorder individuals who die by suicide differ from those borderlines typically encountered in acute psychiatric settings. Our results suggest that the lethality of borderline personality disorder suicide attempts results from an interaction between impulsivity and the violent-aggressive features associated with cluster B comorbidity. Further, the anxious trait of harm avoidance appears to be protective against suicidal behavior resulting in death.
authors.affiliation: McGill Group for Suicide Studies, Douglas Hospital Research Center, Montreal, Canada.
authors.forename: Alexander
authors.initials: A
authors.lastname: McGirr
authors.forename: Joel
authors.initials: J
authors.lastname: Paris
authors.forename: Alain
authors.initials: A
authors.lastname: Lesage
authors.forename: Johanne
authors.initials: J
authors.lastname: Renaud
authors.forename: Gustavo
authors.initials: G
authors.lastname: Turecki
mesh_terms: D000328:Adult; D000374:Aggression; D001883:Borderline Personality Disorder / Q000453:epidemiology / Q000523:psychology*; D016022:Case-Control Studies; D015897:Comorbidity; D007174:Disruptive, Impulse Control, and Conduct Disorders / Q000453:epidemiology / Q000523:psychology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D013405:Suicide