title: Antimicrobial studies of 2,4-dichloro-5-fluorophenyl containing oxadiazoles.
abstract: A series of 2,4-dichloro-5-fluorophenyl containing 1,3,4-oxadiazoles (10 and 11) were synthesized by POCl3 cyclization of 2,4-dichloro-5-fluorobenzoyl hydrazide (4) and 2-(2,4-dichloro-5-fluorophenyl)cinchoninyl hydrazide (8) with aryloxyacetic acids (9). The structures of newly synthesized compounds were characterized by spectral and elemental analyses. All the compounds were screened for their antibacterial and antifungal activities. Compounds 10a, 10d and 11g showed very good antimicrobial activity. Compound 10d showed good bactericidal and fungicidal activities.
authors.affiliation: Department of Chemistry, Mangalore University, Mangalagangothri, Mangalore, Karnataka 574199, India. karthims02@rediffmail.com
authors.forename: Mari Sithambaram
authors.initials: MS
authors.lastname: Karthikeyan
authors.forename: Dasappa Jagadeesh
authors.initials: DJ
authors.lastname: Prasad
authors.forename: Manjathuru
authors.initials: M
authors.lastname: Mahalinga
authors.forename: Bantwal Shivarama
authors.initials: BS
authors.lastname: Holla
authors.forename: Nalilu Suchetha
authors.initials: NS
authors.lastname: Kumari
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D005658:Fungi / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D010069:Oxadiazoles / Q000737:chemistry* / Q000494:pharmacology*; D013055:Spectrophotometry, Infrared; D013329:Structure-Activity Relationship
chemical_list: D000890:Anti-Infective Agents; D010069:Oxadiazoles