title: Deprotonation and regioselective addition of 2H-pyrazolo[3,4-c]quinolines to electrophiles.
abstract: The deprotonation and regioselective reaction of 2H-pyrazolo[3,4-c]quinolines with a variety of electrophiles is described. Electrophiles include benzaldehyde, DMF, carbon dioxide, and iodine. This method provides a direct route to a class of pharmacologically interesting compounds.
authors.affiliation: 3M Pharmaceuticals, 3M Center, Building 270-4S-02, St. Paul, Minnesota 55144-1000, USA. mdanielson@biotherapharma.com
authors.forename: Michael E
authors.initials: ME
authors.lastname: Danielson
authors.forename: David S
authors.initials: DS
authors.lastname: Hays
authors.forename: Tushar A
authors.initials: TA
authors.lastname: Kshirsagar
authors.forename: Chad A
authors.initials: CA
authors.lastname: Haraldson
authors.forename: Gregory D
authors.initials: GD
authors.lastname: Lundquist
authors.forename: Joshua R
authors.initials: JR
authors.lastname: Wurst
authors.forename: Kyle J
authors.initials: KJ
authors.lastname: Lindstrom
authors.forename: Sonja S
authors.initials: SS
authors.lastname: Mackey
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Willie
authors.forename: Philip D
authors.initials: PD
authors.lastname: Heppner
authors.forename: Charles M
authors.initials: CM
authors.lastname: Leir
authors.forename: Karl E
authors.initials: KE
authors.lastname: Benson
mesh_terms: D001547:Benzaldehydes / Q000737:chemistry; D002245:Carbon Dioxide / Q000737:chemistry; D004126:Dimethylformamide / Q000737:chemistry; D007455:Iodine / Q000737:chemistry; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D001547:Benzaldehydes; D011720:Pyrazoles; D011804:Quinolines; D002245:Carbon Dioxide; D004126:Dimethylformamide; D007455:Iodine; C032175:benzaldehyde