title: Endoscopic treatment of large superficial colorectal tumors: a case series of 200 endoscopic submucosal dissections (with video).
abstract: BACKGROUND
  Endoscopic submucosal dissection (ESD) is accepted as a minimally invasive treatment for early gastric cancer; however, it is not widely used in the colorectum because of its technical difficulty.
  
  
  OBJECTIVE
  To determine the feasibility of using ESD for treating large superficial colorectal tumors and to evaluate the clinical outcome.
  
  
  METHODS
  Case series conducted at the National Cancer Center Hospital in Tokyo.
  
  
  METHODS
  A total of 198 consecutive patients were treated for 200 lesions.
  
  
  METHODS
  Procedures were performed, before July 2004, by using a monopolar needle knife or an insulation-tipped knife (IT knife). After July 2004, the procedures were performed by using a bipolar needle knife or an IT knife. After injection of glycerol and sodium hyaluronate acid into the submucosal (sm) layer, a circumferential incision was made and sm dissection was performed endoscopically.
  
  
  METHODS
  The en bloc resection rate was 84% and the curative resection rate was 83%.
  
  
  RESULTS
  Among the 200 ESDs, 51 involved tubular adenomas, 99 intramucosal cancers, 22 minute sm cancers, and 28 sm deep cancers. The median operation time was 90 minutes, and the mean size of resected specimens was 38 mm (range, 20-150 mm). Perforations occurred in 10 cases (5%) and postoperative bleeding in 4 cases (2%), but only 1 perforation case needed emergency surgery, because endoscopic clipping was ineffective.
  
  
  CONCLUSIONS
  No long-term outcome data yet.
  
  
  CONCLUSIONS
  ESD is a feasible technique for treating large superficial colorectal tumors, because it provides a higher en bloc resection rate and is less invasive than surgical resection.
authors.affiliation: Division of Endoscopy, National Cancer Center Hospital, Tokyo, Japan.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Saito
authors.forename: Toshio
authors.initials: T
authors.lastname: Uraoka
authors.forename: Takahisa
authors.initials: T
authors.lastname: Matsuda
authors.forename: Fabian
authors.initials: F
authors.lastname: Emura
authors.forename: Hisatomo
authors.initials: H
authors.lastname: Ikehara
authors.forename: Yumi
authors.initials: Y
authors.lastname: Mashimo
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Kikuchi
authors.forename: Kuang-I
authors.initials: KI
authors.lastname: Fu
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Sano
authors.forename: Daizo
authors.initials: D
authors.lastname: Saito
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015179:Colorectal Neoplasms / Q000145:classification / Q000150:complications / Q000473:pathology / Q000601:surgery*; D013505:Digestive System Surgical Procedures / Q000379:methods; D016099:Endoscopy, Gastrointestinal / Q000009:adverse effects / Q000379:methods*; D005240:Feasibility Studies; D005260:Female; D006470:Hemorrhage / Q000209:etiology; D006801:Humans; D007413:Intestinal Mucosa / Q000473:pathology / Q000601:surgery*; D007416:Intestinal Perforation / Q000209:etiology; D008297:Male; D018715:Microscopy, Video; D008875:Middle Aged; D012008:Recurrence; D016896:Treatment Outcome