title: Diversity of detoxification pathways of ingested ecdysteroids among phytophagous insects.
abstract: The metabolic pathways of ingested ecdysteroids have been investigated in three insect species, the aphid Myzus persicae and two Lepidoptera, Plodia interpunctella and Ostrinia nubilalis. M. persicae produces mainly a 22-glucoside conjugate, whereas P. interpunctella eliminates a mixture of 20E and its 3-oxo and 3-epi derivatives, both in free form and as conjugates with various fatty acids. O. nubilalis only produces fatty acyl ester conjugates. These data point out the great diversity of detoxification mechanisms used by phytophagous insects in order to overcome the potential harmful effects of ecdysteroids present in their food.
authors.affiliation: Université Abdelmalek Essaadi, Faculté des Sciences et Techniques, CEEM-Laboratoire de Biologie Appliquée et Sciences de l'Environnement, Tangier, Morocco.
authors.forename: Kacem
authors.initials: K
authors.lastname: Rharrabe
authors.forename: Salah
authors.initials: S
authors.lastname: Alla
authors.forename: Annick
authors.initials: A
authors.lastname: Maria
authors.forename: Fouad
authors.initials: F
authors.lastname: Sayah
authors.forename: René
authors.initials: R
authors.lastname: Lafont
mesh_terms: D000818:Animals; D001042:Aphids / Q000378:metabolism*; D004440:Ecdysone / Q000493:pharmacokinetics*; D004441:Ecdysterone / Q000737:chemistry / Q000493:pharmacokinetics*; D004950:Esterases / Q000378:metabolism; D005243:Feces / Q000737:chemistry; D008658:Inactivation, Metabolic / Q000502:physiology*; D007814:Larva / Q000378:metabolism; D007915:Lepidoptera / Q000378:metabolism*; D013997:Time Factors; D014316:Tritium / Q000032:analysis
chemical_list: D014316:Tritium; D004440:Ecdysone; D004441:Ecdysterone; D004950:Esterases