Effect of peroxisome proliferator-activated receptor-alpha agonist (bezafibrate) on gastric secretion and gastric cytoprotection in rats.
The effect of peroxisome proliferator-activated receptor-alpha (PPAR-alpha) on gastric secretion and gastric cytoprotection was evaluated using five different models of gastric ulcers: acetic acid-induced chronic gastric ulcers, pylorus ligation, ethanol-induced, indomethacin-induced and ischemia-reperfusion-induced gastric ulcers. Bezafibrate, a PPAR-alpha agonist was administered at two different doses of 10 and 100 mg/kg body weight intraperitoneanally. Both doses of bezafibrate showed significant antiulcer effect in ethanol-induced, indomethacin-induced and pylorus ligation-induced gastric ulcers. Bezafibrate increased healing of ulcer in acetic acid-induced chronic gastric ulcer model. Both doses were also effective in preventing gastric lesions induced by ischemia-reperfusion. It was concluded that PPAR-alpha activation increases healing of gastric ulcers and also prevents development of gastric ulcers in rats.
Pathak
Rahul
R
Department of Pharmacology, Krupanidhi College of Pharmacy, #5 Sarjapur Road, Koramangala, Bangalore 560 034, India.
Asad
Mohammed
M
Hrishikeshavan
H Jagannath
HJ
Prasad
Satya
S
D019342:Acetic Acid; D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D001629:Bezafibrate / Q000494:pharmacology*; D000431:Ethanol; D005744:Gastric Acid / Q000378:metabolism; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D007213:Indomethacin; D008297:Male; D009093:Mucus / Q000378:metabolism; D047493:PPAR alpha / Q000819:agonists*; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology
D000897:Anti-Ulcer Agents; D047493:PPAR alpha; D000431:Ethanol; D019342:Acetic Acid; D007213:Indomethacin; D001629:Bezafibrate