Cytotoxic prenylated phenolic compounds from the twig bark of Garcinia xanthochymus.
Three new hydroxylated xanthones with prenyl or geranyl substituents, compounds 1-3, were isolated from the twig bark of Garcinia xanthochymus, along with the four known compounds 1,4,5,6-tetrahydroxy-7,8-diprenylxanthone (4), 1,3,5,6-tetrahydroxy-4,7,8-triprenylxanthone (5), garciniaxanthone E (6), and 6-prenylapigenin (7). Their structures were elucidated by extensive spectroscopic analysis, including 1D- and 2D-NMR as well as HR-MS experiments. All compounds showed moderate cytotoxicities against breast cancer (MDA-MB-435S) and lung adenocarcinoma (A549) cell lines, but lacked antifungal activity against Candida albicans.
Han
Quan-Bin
QB
Laboratory of Chinese Medicine, Hong Kong Jockey Club Institute of Chinese Medicine, Hong Kong, PR China.
Qiao
Chun-Feng
CF
Song
Jing-Zheng
JZ
Yang
Nian-Yun
NY
Cao
Xin-Wei
XW
Peng
Yong
Y
Yang
Da-Jian
DJ
Chen
Shi-Lin
SL
Xu
Hong-Xi
HX
D000935:Antifungal Agents / Q000302:isolation & purification / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D001562:Benzimidazoles / Q000302:isolation & purification / Q000494:pharmacology; D001943:Breast Neoplasms / Q000473:pathology; D002176:Candida albicans / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects*; D003517:Cyclopentanes / Q000302:isolation & purification / Q000494:pharmacology; D029760:Garcinia / Q000737:chemistry*; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology; D010636:Phenols / Q000302:isolation & purification / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects; D044004:Xanthones / Q000302:isolation & purification / Q000494:pharmacology
C436284:2-cyclopentyl-5-(5-isoquinolylsulfonyl)-6-nitro-1H-benzo(D)imidazole; D000935:Antifungal Agents; D000970:Antineoplastic Agents; D001562:Benzimidazoles; D003517:Cyclopentanes; D010636:Phenols; D044004:Xanthones