title: Change in cardiovascular risk status after dental clearance.
abstract: There is considerable debate over the relationship between periodontal and cardiovascular disease. It has been postulated that inflammatory mediators prevalent in periodontal disease may impact on atheroma formation and the thrombotic process. In cross-sectional, observational studies, periodontitis is associated with elevated C-reactive protein (CRP), hyperfibrinogenaemia and moderate leukocytosis. CRP levels have also been shown to decrease following periodontal therapy. CRP is a reliable marker of the acute phase reaction to infections and/or inflammation and is a powerful predictor of future coronary events.
authors.affiliation: School of Dental Sciences, University of Newcastle upon Tyne, Framlington Place, UK.
authors.forename: J S
authors.initials: JS
authors.lastname: Ellis
authors.forename: P A
authors.initials: PA
authors.lastname: Averley
authors.forename: P M
authors.initials: PM
authors.lastname: Preshaw
authors.forename: J G
authors.initials: JG
authors.lastname: Steele
authors.forename: R A
authors.initials: RA
authors.lastname: Seymour
authors.forename: J M
authors.initials: JM
authors.lastname: Thomason
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis*; D002318:Cardiovascular Diseases / Q000097:blood* / Q000209:etiology; D004812:Epidemiologic Methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010510:Periodontal Diseases / Q000150:complications*; D014081:Tooth Extraction
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein