The effect of saccharic alcohols on rheological parameters of dental anti-inflammatory gels and on pharmaceutical availability of sodium ibuprofen.
A prescription of model dental anti-inflammatory gels has been worked out on the base of cellulose derivatives with the content of saccharic alcohols: xylitol and sorbitol. The effect of saccharic alcohol on rheological parameters (extensibility and viscosity) of the produced gels was tested. Taking into account application, the most beneficial results of rheological tests were obtained for gels containing in their prescription both xylitol and sorbitol in the quantity ratio 1:1. These gels are characterised by high extensibility, low viscosity and low value of yield stress. Theoretical diffusion coefficient of sodium ibuprofen calculated on the basis of viscosity measurements points to the highest pharmaceutical availability of therapeutic agent from model gels with xylitol and sorbitol. The above has been confirmed by in vitro studies of the sodium ibuprofen kinetics of release from gel to the dialysis fluid.
Kołodziejska
Justyna
J
Department of Applied Pharmacy, Medical University of Lódź, 1 Muszyńskiego Str., 90-151 Lódź, Poland.
D000465:Algorithms; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000493:pharmacokinetics*; D020100:Hydrogels; D007052:Ibuprofen / Q000737:chemistry / Q000493:pharmacokinetics*; D007700:Kinetics; D053210:Pharmaceutical Preparations, Dental / Q000737:chemistry; D012212:Rheology; D013012:Sorbitol / Q000737:chemistry*; D014783:Viscosity; D014993:Xylitol / Q000737:chemistry*
D000893:Anti-Inflammatory Agents; D020100:Hydrogels; D053210:Pharmaceutical Preparations, Dental; D013012:Sorbitol; D014993:Xylitol; D007052:Ibuprofen