title: Biological studies of new organotin(IV) complexes of thioamide ligands.
abstract: New organotin(IV) complexes with heterocyclic thioamides 2-mercapto-benzothiazole (Hmbzt), 5-chloro-2-mercapto-benzothiazole (Hcmbzt) and 2-mercapto-benzoxazole (Hmbzo) of formulae [(C(6)H(5))(3)Sn(mbzt)] (1), [(C(6)H(5))(3)Sn(cmbzt)] (3) and [(C(6)H(5))(2)Sn(cmbzt)(2)] (4), together with the already known [(C(6)H(5))(3)Sn(mbzo)] (2), [(n-C(4)H(9))(2)Sn(cmbzt)(2)] (5) and [(CH(3))(2)Sn(cmbzt)(2)] (6) were used to study their influence on the peroxidation of oleic acid. The influence of complexes (3)-(6) upon peroxidation of oleic acid showed that the formation of reactive radicals caused the initiation of the chain radical oxidation of the substrate. The influence of complexes (1)-(6) upon the catalytic peroxidation of linoleic acid by the enzyme lipoxygenase (LOX) was also studied and compared to those of cisplatin. Compounds (1)-(6) were finally tested for in vitro cytotoxicity against leiomyosarcoma cells.
authors.affiliation: Inorganic and Analytical Chemistry, Department of Chemistry, University of Ioannina, 45110 Ioannina, Greece. me00635@cc.uoi.gr
authors.forename: Marianna N
authors.initials: MN
authors.lastname: Xanthopoulou
authors.forename: Sotiris K
authors.initials: SK
authors.lastname: Hadjikakou
authors.forename: Nick
authors.initials: N
authors.lastname: Hadjiliadis
authors.forename: Elena R
authors.initials: ER
authors.lastname: Milaeva
authors.forename: Julia A
authors.initials: JA
authors.lastname: Gracheva
authors.forename: Vladimir Yu
authors.initials: VY
authors.lastname: Tyurin
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Kourkoumelis
authors.forename: Kostantinos C
authors.initials: KC
authors.lastname: Christoforidis
authors.forename: Apostolos K
authors.initials: AK
authors.lastname: Metsios
authors.forename: Spyros
authors.initials: S
authors.lastname: Karkabounas
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Charalabopoulos
mesh_terms: D002384:Catalysis; D019787:Linoleic Acid / Q000737:chemistry; D015227:Lipid Peroxidation; D009947:Organotin Compounds / Q000737:chemistry / Q000494:pharmacology*; D010084:Oxidation-Reduction; D013854:Thioamides / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D009947:Organotin Compounds; D013854:Thioamides; D019787:Linoleic Acid