Does sphingosine-1-phosphate have a protective effect on cyclophosphamide- and irradiation-induced ovarian damage in the rat model?
The aim of this study was to assess the possible protective effect of sphingosine-1-phosphate (S1P), a polar sphingoid metabolite that seemingly promotes cell survival, on cytotoxin- and irradiation-induced ovarian injury in the rat model. Administration of S1P into ovarian bursa before whole-body irradiation led to decreased percentage of apoptotic cells, mostly in primordial follicles; however, S1P was not effective against apoptosis in rats that were given intraperitoneal cyclophosphamide.
Kaya
Hakan
H
Department of Obstetrics and Gynecology, Suleyman Demirel University, School of Medicine, Isparta, Turkey.
Desdicioglu
Raziye
R
Sezik
Mekin
M
Ulukaya
Engin
E
Ozkaya
Okan
O
Yilmaztepe
Arzu
A
Demirci
Meral
M
D000818:Animals; D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage; D017209:Apoptosis; D003520:Cyclophosphamide / Q000008:administration & dosage; D004195:Disease Models, Animal; D005260:Female; D007274:Injections, Intraperitoneal; D008246:Lysophospholipids / Q000378:metabolism*; D010049:Ovarian Diseases / Q000139:chemically induced / Q000378:metabolism / Q000517:prevention & control*; D006080:Ovarian Follicle / Q000378:metabolism* / Q000473:pathology; D010062:Ovulation Induction; D011833:Radiation Injuries, Experimental / Q000209:etiology / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D051381:Rats; D017208:Rats, Wistar; D013110:Sphingosine / Q000031:analogs & derivatives* / Q000378:metabolism; D014916:Whole-Body Irradiation / Q000009:adverse effects
D018906:Antineoplastic Agents, Alkylating; D008246:Lysophospholipids; C060506:sphingosine 1-phosphate; D003520:Cyclophosphamide; D013110:Sphingosine