title: Regulation of B versus T lymphoid lineage fate decision by the proto-oncogene LRF.
abstract: Hematopoietic stem cells in the bone marrow give rise to lymphoid progenitors, which subsequently differentiate into B and T lymphocytes. Here we show that the proto-oncogene LRF plays an essential role in the B versus T lymphoid cell-fate decision. We demonstrate that LRF is key for instructing early lymphoid progenitors in mice to develop into B lineage cells by repressing T cell-instructive signals produced by the cell-fate signal protein, Notch. We propose a new model for lymphoid lineage commitment, in which LRF acts as a master regulator of the cell's determination of B versus T lineage.
authors.affiliation: Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Maeda
authors.forename: Taha
authors.initials: T
authors.lastname: Merghoub
authors.forename: Robin M
authors.initials: RM
authors.lastname: Hobbs
authors.forename: Lin
authors.initials: L
authors.lastname: Dong
authors.forename: Manami
authors.initials: M
authors.lastname: Maeda
authors.forename: Johannes
authors.initials: J
authors.lastname: Zakrzewski
authors.forename: Marcel R M
authors.initials: MR
authors.lastname: van den Brink
authors.forename: Arthur
authors.initials: A
authors.lastname: Zelent
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Shigematsu
authors.forename: Koichi
authors.initials: K
authors.lastname: Akashi
authors.forename: Julie
authors.initials: J
authors.lastname: Teruya-Feldstein
authors.forename: Giorgio
authors.initials: G
authors.lastname: Cattoretti
authors.forename: Pier Paolo
authors.initials: PP
authors.lastname: Pandolfi
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology* / Q000502:physiology; D001854:Bone Marrow Cells / Q000166:cytology; D019070:Cell Lineage; D002478:Cells, Cultured; D004268:DNA-Binding Proteins / Q000235:genetics* / Q000502:physiology; D017353:Gene Deletion; D006412:Hematopoietic Stem Cells / Q000166:cytology* / Q000502:physiology; D038041:Lymphopoiesis; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D008954:Models, Biological; D011519:Proto-Oncogenes; D051880:Receptors, Notch / Q000378:metabolism*; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000166:cytology* / Q000502:physiology; D013950:Thymus Gland / Q000166:cytology; D014157:Transcription Factors / Q000235:genetics* / Q000502:physiology
chemical_list: D004268:DNA-Binding Proteins; D051880:Receptors, Notch; D014157:Transcription Factors; C117093:Zbtb7a protein, mouse