Discovery of para-alkylthiophenoxyacetic acids as a novel series of potent and selective PPARdelta agonists.
A novel series of potent and selective PPARdelta agonists, para-alkylthiophenoxyacetic acids, was identified. The synthesis and structure-activity relationships are described.
Zhang
Rui
R
Drug Discovery, Johnson and Johnson Pharmaceutical Research and Development, LLC, 8 Clarke Drive, Cranbury, NJ 08512, USA. rzhang4@prdus.jnj.com
Wang
Aihua
A
DeAngelis
Alan
A
Pelton
Patricia
P
Xu
Jun
J
Zhu
Peifang
P
Zhou
Lubing
L
Demarest
Keith
K
Murray
William V
WV
Kuo
Gee-Hong
GH
D019540:Area Under Curve; D006016:Glycolates / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology*; D047494:PPAR delta / Q000819:agonists*; D013329:Structure-Activity Relationship
D006016:Glycolates; D047494:PPAR delta; C005446:thiophenoxyacetic acid