Development and physiological regulation of intestinal lipid absorption. I. Development of intestinal lipid absorption: cellular events in chylomicron assembly and secretion.
The newborn mammal must efficiently absorb dietary fat, predominantly as triacylglycerol, and produce chylomicrons to deliver this lipid to peripheral tissues. The cellular mechanisms involved in enterocyte chylomicron assembly have recently been elucidated, and data on their regulation in the immature gut are beginning to emerge. This review focuses on key proteins involved in chylomicron assembly: apolipoprotein B-48, microsomal triglyceride transfer protein, and apolipoprotein A-IV. Recent studies support a role for apolipoprotein A-IV in enhancing chylomicron secretion by promoting production of larger particles. These proteins are regulated in a manner to maximize the lipid absorptive capacity of the newborn intestine.
Black
Dennis D
DD
Children's Foundation Research Center of Memphis, Le Bonheur Children's Medical Center, 50 N. Dunlap Street, Memphis, TN 38103, USA. dblack@utmem.edu
D000818:Animals; D000831:Animals, Newborn; D053283:Apolipoprotein B-48 / Q000235:genetics / Q000378:metabolism; D001054:Apolipoproteins A / Q000235:genetics / Q000378:metabolism; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism; D002914:Chylomicrons / Q000235:genetics / Q000378:metabolism*; D004041:Dietary Fats / Q000378:metabolism*; D004721:Endoplasmic Reticulum / Q000378:metabolism; D020895:Enterocytes / Q000378:metabolism*; D018507:Gene Expression Regulation, Developmental; D051557:Hepatocyte Nuclear Factor 4 / Q000378:metabolism; D006801:Humans; D007231:Infant, Newborn; D007408:Intestinal Absorption / Q000235:genetics; D007413:Intestinal Mucosa / Q000378:metabolism*; D007422:Intestines / Q000166:cytology / Q000254:growth & development; D050356:Lipid Metabolism / Q000235:genetics; D021381:Protein Transport; D012333:RNA, Messenger / Q000378:metabolism; D022161:Transport Vesicles / Q000378:metabolism
D053283:Apolipoprotein B-48; D001054:Apolipoproteins A; D002352:Carrier Proteins; D002914:Chylomicrons; D004041:Dietary Fats; D051557:Hepatocyte Nuclear Factor 4; D012333:RNA, Messenger; C022205:apolipoprotein A-IV; C106092:microsomal triglyceride transfer protein