Cytotoxic dibromotyrosine-derived metabolites from the sponge Aplysina gerardogreeni.
The chemical study of the sponge Aplysina gerardogreeni collected at the Gulf of California has led to the isolation of four new dibromotyrosine-derived metabolites, aplysinones A-D, whose structures were determined by spectroscopic analysis and chemical methods. The new compounds and four semisynthetic analogues prepared in this study have shown cytotoxic activity against human tumor cell lines.
Hernández-Guerrero
Claudia J
CJ
Departamento de Química Orgánica, Facultad de Ciencias del Mar y Ambientales, Universidad de Cádiz, Apdo. 40, 11510-Puerto Real (Cádiz), Spain.
Zubía
Eva
E
Ortega
María J
MJ
Carballo
J Luis
JL
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D045744:Cell Line, Tumor; D006801:Humans; D011161:Porifera / Q000378:metabolism*; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000378:metabolism*
D000970:Antineoplastic Agents; D014443:Tyrosine