Severe cognitive dysfunction in a patient with polyendocrinopathy.
BACKGROUND
Polyglandular Autoimmune syndromes (PGAs) or polyendocrinopathies are immune mediated multiple endocrine gland failure sometimes accompanied by nonendocrine autoimmune disorders with varieties of presentations.


METHODS
We describe a case of a middle aged man with severe cognitive dysfunction, brain atrophy, adrenal insufficiency, hypothyroidism, renal failure, thrombocytopenia, and positive antiphospholipid antibodies, with significant renal and cognitive improvement after hormone replacement.


CONCLUSIONS
PGAs may present with a broad spectrum of manifestations related to different organs like nervous,renal,cardiac and hematopoietic systems, sometimes challenging both to physician and the patient.
Dastjerdi
M Siavash
MS
Isfahan Endocrine & Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. siavash@med.mui.ac.ir
Aminorroaya
A
A
Amini
M
M
Ashrafi
F
F
Kazemi
F
F
Saadatnia
M
M
Mottaghi
P
P
Emami
A
A
D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016884:Polyendocrinopathies, Autoimmune / Q000150:complications* / Q000175:diagnosis