title: The COMT Val158Met polymorphism and temporal lobe morphometry in healthy adults.
abstract: We examined the relationship between COMT Val158Met genotype and temporal lobe volumes, including the caudate as a control region. Thirty-one healthy subjects completed 1.5T brain MRI and genotyping. After controlling for demographics, Val158 allele homozygotes exhibited significantly smaller temporal lobe and hippocampal volumes, with a trend for smaller amygdala volumes.
authors.affiliation: Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA. Taylo066@mc.duke.edu
authors.forename: Warren D
authors.initials: WD
authors.lastname: Taylor
authors.forename: Stephan
authors.initials: S
authors.lastname: Züchner
authors.forename: Martha E
authors.initials: ME
authors.lastname: Payne
authors.forename: Denise F
authors.initials: DF
authors.lastname: Messer
authors.forename: Tracy J
authors.initials: TJ
authors.lastname: Doty
authors.forename: James R
authors.initials: JR
authors.lastname: MacFall
authors.forename: John L
authors.initials: JL
authors.lastname: Beyer
authors.forename: K Ranga R
authors.initials: KR
authors.lastname: Krishnan
mesh_terms: D000328:Adult; D000679:Amygdala / Q000033:anatomy & histology / Q000378:metabolism; D001921:Brain / Q000033:anatomy & histology / Q000201:enzymology / Q000378:metabolism; D002394:Catechol O-Methyltransferase / Q000235:genetics* / Q000378:metabolism; D002421:Caudate Nucleus / Q000033:anatomy & histology / Q000201:enzymology / Q000378:metabolism; D005260:Female; D007839:Functional Laterality / Q000235:genetics; D005838:Genotype; D006720:Homozygote; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000706:statistics & numerical data*; D008297:Male; D008715:Methionine / Q000235:genetics / Q000378:metabolism; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D013702:Temporal Lobe / Q000033:anatomy & histology* / Q000201:enzymology / Q000378:metabolism; D014633:Valine / Q000235:genetics / Q000378:metabolism
chemical_list: D008715:Methionine; D002394:Catechol O-Methyltransferase; D014633:Valine