Dibenzocyclooctane lignans from the stems of Kadsura induta and their antiviral effect on hepatitis B virus.
Two new dibenzocyclooctane lignans, kadsurindutins A (1) and B (2), were isolated from the stems of Kadsura induta, together with the known, structurally related lignans schisantherin L (3), schisantherin P (4), kadsulignan L (5), and neokadsuranin (6). Their structures and configurations were elucidated by spectroscopic methods (UV, ORD, CD, IR, 1D- and 2D-NMR) in combination with mass-spectrometric (HR-MS) techniques. Compounds 1, 5, and 6 showed in vitro antiviral effects on hepatitis B virus.
Ma
Wenhui
W
Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai 200032, PR China.
Ma
Xiaolin
X
Huang
Hai
H
Zhou
Pei
P
Chen
Daofeng
D
D000998:Antiviral Agents / Q000302:isolation & purification / Q000494:pharmacology*; D052117:Benzodioxoles / Q000302:isolation & purification / Q000494:pharmacology*; D034242:Cyclooctanes / Q000302:isolation & purification / Q000494:pharmacology*; D006515:Hepatitis B virus / Q000187:drug effects*; D032135:Kadsura / Q000737:chemistry*; D017705:Lignans / Q000302:isolation & purification / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry
C520754:5,6,7,8-tetrahydro-13,14-dimethoxy-6,7-dimethyl-5-(2-methylbut-2-enoyl)oxy(1,3)benzodioxolo(5',6'-3,4)cycloocta(1,2-f)(1,3)benzodioxol-6,8-diol; C520753:8-acetoxy-5,6,7,8-tetrahydro-13,14-dimethoxy-6,7-dimethyl-5-(2-methylbut-2-enoyl)oxy(1,3)benzodioxolo(5',6'-3,4)cycloocta(1,2-f)(1,3)benzodioxol-6-ol; D000998:Antiviral Agents; D052117:Benzodioxoles; D034242:Cyclooctanes; D017705:Lignans; D010936:Plant Extracts; C477962:kadsulignan L