A FAScinating receptor in self-tolerance.
In this issue of Immunity,Stranges et al. (2007) ablate expression of the death receptor Fas in T cells, B cells, and DC. Fas deficiency in any of these lineages is sufficient to break self-tolerance.
Ramaswamy
Madhu
M
Immunoregulation Unit, Autoimmunity Branch, NIAMS, National Institutes of Health, Bethesda, MD 20892, USA.
Siegel
Richard M
RM
D000818:Animals; D017951:Antigen Presentation / Q000276:immunology; D016923:Cell Death; D006801:Humans; D017634:Self Tolerance / Q000276:immunology*; D019014:fas Receptor / Q000276:immunology*
D019014:fas Receptor