Highly enantioselective Friedel-Crafts alkylations of indoles with simple enones catalyzed by zirconium(IV)-BINOL complexes.
Complexes of BINOL-based ligands with Zr(OtBu)4 catalyze the Friedel-Crafts alkylation reaction of indoles and pyrrole with nonchelating beta-substituted alpha,beta-enones at room temperature affording the expected products with good yields and ee above 95% in most of the studied examples.
Blay
Gonzalo
G
Departament de Química Orgànica, Facultat de Química, Universitat de València, E-46100-Burjassot, València, Spain.
Fernández
Isabel
I
Pedro
José R
JR
Vila
Carlos
C