[Peculiarities of postprandial activity of lipoprotein lipase in coronary heart disease].
The aim of investigation was to study the peculiarities of activity of lipoprotein lipase (LPL) and serum lipid spectrum after fat test meal in patients with coronary heart disease (CHD). 42 persons have been investigated. The main group consisted of 27 patients with CHD (13 males, 14 females). 15 almost healthy subjects (5 males, 10 females) were unified in control group. Parameters of lipid metabolism have been studied by biochemical technique both in basal state and at 3 hours after standard test meal. In parallel, the levels of LPL activity have been investigated by potentiometric method. The values of LPL activity in patients with CHD both in basal and in postprandial states were significantly lower in comparison with analogous values of control subjects. Its postprandial level in CHD patients did not change significantly (percentage increment was 1,0+/-0,9%), but in control group - was increased by 22,3+/-4,4%. Obtained results suggest that LPL activity is not increased at increased postprandial atherogenic lipemia in patients with CHD. LPL activity should be considered as a metabolic marker of atherogenesis and CHD.
Svanidze
N O
NO
Kavtaradze
G V
GV
Shaburishvili
T Sh
TSh
Dzhavashvili
L V
LV
Tananashvili
D E
DE
D000328:Adult; D003327:Coronary Disease / Q000201:enzymology* / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008071:Lipoprotein Lipase / Q000378:metabolism / Q000502:physiology*; D008297:Male; D019518:Postprandial Period / Q000502:physiology*
D008071:Lipoprotein Lipase