The discovery of long acting beta2-adrenoreceptor agonists.
The design and profile of a series of saligenin containing long acting beta(2)-adrenoreceptor agonists is described. Evaluation of these analogues using a guinea-pig tissue model demonstrates that analogues within this series have significantly longer durations of action than salmeterol and have the potential for a once daily profile in human.
Brown
Alan D
AD
Pfizer Global Research and Development, Sandwich Laboratories, Ramsgate Road, Sandwich, Kent CT13 9NJ, UK.
Bunnage
Mark E
ME
Glossop
Paul A
PA
James
Kim
K
Jones
Rhys
R
Lane
Charlotte A L
CA
Lewthwaite
Russell A
RA
Mantell
Simon
S
Perros-Huguet
Christelle
C
Price
David A
DA
Trevethick
Mike
M
Webster
Rob
R
D058665:Adrenergic beta-1 Receptor Agonists; D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000818:Animals; D018938:Caco-2 Cells; D006801:Humans; D051379:Mice
D058665:Adrenergic beta-1 Receptor Agonists; D000318:Adrenergic beta-Agonists