title: Synthesis of kaempferitrin.
abstract: A short synthesis of Kaempferitrin (1), a 3,7-diglycosylflavone, is reported. Key features include the synthesis of a protected form of kaempferol in which all four hydroxy groups are differentiated and the first bis-glycosylation of a dihydroxyflavone. This synthesis will allow the preparation of derivatives for further explorations into the origins of this compound's biological activity.
authors.affiliation: Chemical Biology Program, Broad Institute of Harvard and MIT, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA.
authors.forename: Sameer
authors.initials: S
authors.lastname: Urgaonkar
authors.forename: Jared T
authors.initials: JT
authors.lastname: Shaw
mesh_terms: D006031:Glycosylation; D044949:Kaempferols / Q000138:chemical synthesis* / Q000737:chemistry; D010696:Phloroglucinol / Q000737:chemistry
chemical_list: D044949:Kaempferols; D010696:Phloroglucinol; C042728:lespenefril