title: Diagnostic accuracy of multidetector computed tomography coronary angiography in patients with dilated cardiomyopathy.
abstract: OBJECTIVE
  The purpose of this work was to assess the safety, feasibility, and diagnostic accuracy of multidetector computed tomography (MDCT) in dilated cardiomyopathy (DCM) of unknown etiology.
  
  
  BACKGROUND
  Multidetector computed tomography is an appropriate noninvasive tool for coronary artery disease (CAD) detection, particularly in patients with low probability of the disease, such as patients with DCM of unknown origin.
  
  
  METHODS
  We studied 61 unknown origin DCM patients (ejection fraction: 33.9 +/- 8.6%, group 1) and 139 patients with normal cardiac function with indications for coronary angiography (group 2, control population). All underwent coronary MDCT and angiography. Multidetector computed tomography images were acquired by light speed 16-slice computed tomography. The degree of stenosis was estimated in 15 coronary artery segments according to the American Heart Association model.
  
  
  RESULTS
  In group 1, no MDCT-related complications were found, while 10 complications were associated with conventional angiography (p = 0.001). Overall feasibility of coronary artery visualization was 97.2% (863 of 888 segments). The most frequent cause of artifacts was interference from a hypertrophic cardiac venous system (10 artifacts, 40%). In group 2, overall feasibility was 96.1% (p = NS vs. group 1). In group 1, all cases with normal (44 cases) or pathological (17 cases) coronary arteries by conventional coronary angiography were correctly detected by MDCT, with, in 1 case, disparity of stenosis severity. In group 1, sensitivity, specificity, and positive and negative predictive values of MDCT for the identification of >50% stenosis were 99%, 96.2%, 81.2%, and 99.8%, respectively. In group 2, sensitivity and negative predictive values were lower than in group 1 (86.1% vs. 99% and 96.4% vs. 99.8%, respectively); specificity (96.4%) and positive predictive value (86.1%) were not significantly different versus group 1.
  
  
  CONCLUSIONS
  Multidetector computed tomography is feasible, safe, and accurate for identification of idiopathic versus ischemic DCM, and may represent an alternative to coronary angiography.
authors.affiliation: Centro Cardiologico Monzino, IRCCS, Institute of Cardiology, University of Milan, Milan, Italy. daniele.andreini@ccfm.it
authors.forename: Daniele
authors.initials: D
authors.lastname: Andreini
authors.forename: Gianluca
authors.initials: G
authors.lastname: Pontone
authors.forename: Mauro
authors.initials: M
authors.lastname: Pepi
authors.forename: Giovanni
authors.initials: G
authors.lastname: Ballerini
authors.forename: Antonio L
authors.initials: AL
authors.lastname: Bartorelli
authors.forename: Alessandra
authors.initials: A
authors.lastname: Magini
authors.forename: Carlo
authors.initials: C
authors.lastname: Quaglia
authors.forename: Enrica
authors.initials: E
authors.lastname: Nobili
authors.forename: Piergiuseppe
authors.initials: P
authors.lastname: Agostoni
mesh_terms: D016477:Artifacts; D002311:Cardiomyopathy, Dilated / Q000000981:diagnostic imaging*; D003287:Contrast Media; D017023:Coronary Angiography / Q000379:methods*; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging*; D023921:Coronary Stenosis / Q000000981:diagnostic imaging*; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007479:Iopamidol / Q000031:analogs & derivatives; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D003287:Contrast Media; C057937:iomeprol; D007479:Iopamidol