Propriospinal myoclonus: utility of magnetic resonance diffusion tensor imaging and fiber tracking.
Propriospinal myoclonus (PSM) is a rare movement disorder characterized by involuntary spinal-generated muscular jerks that spread rostrally and caudally to other spinally innervated muscles. Most patients have no clear etiology, and conventional MRI of the spinal cord is generally normal. Here we report the use of magnetic resonance diffusion tensor imaging (DTI) and fiber tracking to detect tract-specific abnormalities in a patient with propriospinal myoclonus. As the patient had the fragile-X premutation and antithyroid antibodies, spinal cord DTI abnormalities may be related to these conditions. Tract-specific analysis may provide new insights into the pathophysiology of propriospinal myoclonus.
Roze
Emmanuel
E
Department of Neurology, Saint-Antoine Hospital, AP-HP, Paris, France.|CNRS UMR 7102, Paris VI University, Paris, France.
Apartis
Emmanuelle
E
Department of Neurophysiology, Saint Antoine Hospital, AP-HP, Paris, France.|INSERM U732, Paris VI University, Paris, France.
Vidailhet
Marie
M
Department of Neurology, Saint-Antoine Hospital, AP-HP, Paris, France.|INSERM U679, Paris, France.
Cochen
Valérie
V
Department of Neurology, Saint-Antoine Hospital, AP-HP, Paris, France.|INSERM U679, Paris, France.
Beaugendre
Yara
Y
Department of Neurophysiology, Saint Antoine Hospital, AP-HP, Paris, France.|Department of Neurophysiology, Henri Mondor Hospital, AP-HP, Creteil, France.
Trocello
Jean-Marc
JM
Department of Neurology, Saint-Antoine Hospital, AP-HP, Paris, France.|Department of Neurophysiology, Saint Antoine Hospital, AP-HP, Paris, France.|INSERM U732, Paris VI University, Paris, France.
Lasjaunias
Pierre
P
Department of Neuroradiology, Bicêtre Hospital, AP-HP, Paris, France.
Ducreux
Denis
D
Department of Neuroradiology, Bicêtre Hospital, AP-HP, Paris, France.
D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods; D006801:Humans; D008297:Male; D008875:Middle Aged; D009207:Myoclonus / Q000175:diagnosis* / Q000503:physiopathology*; D009412:Nerve Fibers / Q000473:pathology*; D013116:Spinal Cord / Q000473:pathology* / Q000503:physiopathology*