title: Preliminary evaluation of antioxidant activity of some 1-(phenoxyethyl)-piperazine derivatives.
abstract: The antioxidant properties of appropriate 1-(phenoxyethyl)-piperazine derivatives possessing significant hypotensive activity in normotensive rats were measured in human venous blood samples, in vitro. Ferric reducing ability of plasma (FRAP) was measured in plasma, superoxide dismutase (SOD) and catalase (CAT) activities were determined in red blood cell hemolysates. Antioxidant profile of 1-(phenoxyethyl)-piperazine derivatives was compared to Trolox and Resveratrol. The compounds were investigated in concentrations from 10(-8) to 10(-4) mol x L(-1). The most promising compounds were 1-[(4-methyl)- and 1-[(2,6-dimethyl)-phenoxyethyl]-piperazine derivatives [1, 2] which increased SOD activity and total antioxidant capacity (TAC). An addition of chlorine atom to methyl-phenoxy moiety decreased antioxidant properties.
authors.affiliation: Radioligand Laboratory, Faculty of Pharmacy, Medical College, Jagiellonian University, 9 Medyczna Str., 30-688 Kraków, Poland.
authors.forename: Agata
authors.initials: A
authors.lastname: Pietrzycka
authors.forename: Marek
authors.initials: M
authors.lastname: Stepniewski
authors.forename: Anna M
authors.initials: AM
authors.lastname: Waszkielewicz
authors.forename: Henryk
authors.initials: H
authors.lastname: Marona
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000138:chemical synthesis* / Q000494:pharmacology*; D002374:Catalase / Q000097:blood / Q000378:metabolism; D005260:Female; D005290:Ferric Compounds / Q000737:chemistry; D006801:Humans; D008297:Male; D015428:Myocardial Reperfusion Injury / Q000201:enzymology; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000187:drug effects; D010879:Piperazines / Q000138:chemical synthesis* / Q000494:pharmacology*; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology; D013482:Superoxide Dismutase / Q000097:blood / Q000378:metabolism
chemical_list: D000975:Antioxidants; D005290:Ferric Compounds; D010879:Piperazines; D013267:Stilbenes; D002374:Catalase; D013482:Superoxide Dismutase; D000077185:Resveratrol