Transcranial magnetic stimulation reduces pain in patients with major depression: a sham-controlled study.
This study evaluated the change in reported pain in patients with medication-resistant major depression receiving transcranial magnetic stimulation (TMS) compared with sham stimulation. In this study, 68 subjects with major depression were randomized to either TMS or sham stimulation. Repetitive TMS was delivered to the left dorsolateral prefrontal cortex at a frequency of 10 Hz in 5-second trains at 110% of the estimated prefrontal cortex threshold. The level of pain was assessed before, during, and after treatment using the Systematic Assessment for Treatment Emergent Effects (SAFTEE) item for pain in the muscles, bones, and joints. Compared with sham, TMS was associated with a significant (p < 0.05) reduction in the SAFTEE pain item during the study. The reduction in pain could not be explained by the antidepressant effects.
Avery
David H
DH
Department of Psychiatry and Behavioral Sciences, Harborview Medical Center, Seattle, Washington 98104-2499, USA. averydh@u.washington.edu
Holtzheimer
Paul E
PE
Fawaz
Walid
W
Russo
Joan
J
Neumaier
John
J
Dunner
David L
DL
Haynor
David R
DR
Claypoole
Keith H
KH
Wajdik
Chandra
C
Roy-Byrne
Peter
P
D000328:Adult; D000368:Aged; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D039721:Diagnostic and Statistical Manual of Mental Disorders; D004351:Drug Resistance; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D008875:Middle Aged; D010146:Pain / Q000175:diagnosis / Q000503:physiopathology; D059408:Pain Management; D010147:Pain Measurement / Q000706:statistics & numerical data; D017397:Prefrontal Cortex / Q000502:physiology*; D011569:Psychiatric Status Rating Scales; D012044:Regression Analysis; D050781:Transcranial Magnetic Stimulation / Q000379:methods*; D016896:Treatment Outcome