title: [Antifungal activity of the novel adduct, GX-95, of silver with nanometer-scale particles to peptidic hydrolysates from collagen].
abstract: Silver has long been known to have an antimicrobial activity against bacteria and other microorganisms, and has been used as eating utensils, as dental fillings and so on. We developed a novel adduct, GX-95, of silver with nanometer-scale particles to peptidic hydrolysates from collagen. Antifungal activity of the adduct against pathogenic yeasts and filamentous fungi was examined in terms of minimal inhibitory concentrations (MICs). GX-95 was found to possess strong and broad antifungal activities against all fungi examined in the following MICs: 0.25 to 0.31 microg/ml for Candida albicans including resistant strains to fluconazole, itraconazole and flucytosine, 0.05 to 0.2 microg/ml for Cryptococcus neoformans strains, 0.025 to 0.4 microg/ml for Aspergillus fumigatus strains, 0.4 microg/ml for Trichophyton rubrum, and 0.05 microg/ml for Cladophialophora carrionii.
authors.affiliation: Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, 1-801 Inohana, Chuo-ku, Chiba 260-8673, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Yaguchi
authors.forename: Kyoko
authors.initials: K
authors.lastname: Takizawa
authors.forename: Hideaki
authors.initials: H
authors.lastname: Taguchi
authors.forename: Reiko
authors.initials: R
authors.lastname: Tanaka
authors.forename: Tadashi
authors.initials: T
authors.lastname: Kubota
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Kubota
authors.forename: Masaaki
authors.initials: M
authors.lastname: Kubota
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Fukushima
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D003094:Collagen; D005658:Fungi / Q000187:drug effects*; D053758:Nanoparticles; D011492:Protein Hydrolysates; D012834:Silver / Q000494:pharmacology*
chemical_list: D000935:Antifungal Agents; D011492:Protein Hydrolysates; D012834:Silver; D003094:Collagen