title: Filaggrin's fuller figure: a glimpse into the genetic architecture of atopic dermatitis.
abstract: Prevalent mutations in the FLG gene underlie the common skin disorder ichthyosis vulgaris and are significant risk factors for atopic dermatitis (eczema). The recent publication of a strategy to sequence this difficult gene identifies a spectrum of both prevalent and rare mutations that collectively have a significant impact on susceptibility to atopic disease.
authors.affiliation: Epithelial Genetics Group, Human Genetics Unit, University of Dundee, Dundee, UK.
authors.forename: Aileen
authors.initials: A
authors.lastname: Sandilands
authors.forename: Frances J D
authors.initials: FJ
authors.lastname: Smith
authors.forename: Alan D
authors.initials: AD
authors.lastname: Irvine
authors.forename: W H Irwin
authors.initials: WH
authors.lastname: McLean
mesh_terms: D003876:Dermatitis, Atopic / Q000453:epidemiology* / Q000235:genetics*; D000091344:Filaggrin Proteins; D020022:Genetic Predisposition to Disease / Q000453:epidemiology; D006801:Humans; D007381:Intermediate Filament Proteins / Q000235:genetics*; D015995:Prevalence; D012307:Risk Factors
chemical_list: C000717249:FLG protein, human; D000091344:Filaggrin Proteins; D007381:Intermediate Filament Proteins