Laboratory diagnosis of toluene-based inhalants abuse.
Toluene is the main substance contained in products used as inhalants. The frequent abuse of toluene-based inhalants requires the definition of a simple laboratory parameter that allows acute exposure assessment. This study aimed at defining urinary hippuric acid (UHA) levels related to intentional exposure to toluene, and to correlate them to blood toluene concentration (BT).


METHODS
BT and UHA levels were measured in 65 homeless adolescents of Porto Alegre, Brazil.


RESULTS
Toluene was detected in 91.9% of the investigated population, who presented BT levels from 0.5 to 83.7 microg/mL. There was good correlation between UHA and BT concentrations (r = 0.78), and in homeless adolescents, UHA levels higher than 3.0 g/g creatinine indicate intentional exposure to toluene.


CONCLUSIONS
The determination of UHA concentrations can be used as a screening method for the detection of intentional exposure to toluene, but its diagnosis must include BT toluene dosage, as well as circumstantial and clinical evidence.
Thiesen
Flavia Valladão
FV
Pharmacy Faculty and Toxicology Institute, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil. fvthiesen@pucrs.br
Noto
Ana Regina
AR
Barros
Helena M T
HM
D000293:Adolescent; D001938:Brazil; D019411:Clinical Laboratory Techniques; D006626:Hippurates / Q000652:urine*; D018453:Homeless Youth; D006801:Humans; D012997:Solvents / Q000378:metabolism; D015813:Substance Abuse Detection / Q000379:methods*; D019966:Substance-Related Disorders / Q000097:blood / Q000175:diagnosis* / Q000652:urine; D014050:Toluene / Q000097:blood*
D006626:Hippurates; D012997:Solvents; D014050:Toluene; C030514:hippuric acid