title: Lymphotoxin-alpha and galectin-2 SNPs are not associated with myocardial infarction in two different German populations.
abstract: Recent data provided strong evidence for the association of single nucleotide polymorphisms (SNPs) in the lymphotoxin-alpha (LTA) and galectin-2 (LGALS2) genes with myocardial infarction (MI) in a Japanese population. For populations of other genetic background, the relevance of these polymorphisms in the pathogenesis of MI remains controversial. We aimed to define the role of LTA and LGALS2 SNPs in two German MI populations with markedly different ascertainment strategies. Two different MI populations were studied. In the first population, MI patients were ascertained by a strong family history of MI (n = 1214). Controls were unrelated disease-free participants of the study (n = 1080). The second population included patients suffering from sporadic (nonfamilial) MI from the German KORA register (n = 607). The control group consisted of participants of the WHO MONICA survey in Germany (n = 1492). TaqMan assays were used to determine the genotypes of 4 SNPs in the LTA genomic region and 1 SNP in the LGALS2 gene. Single SNPs in both genomic regions as well as haplotypes in the LTA genomic region were tested for association in various models of inheritance. No association with MI could be found for any of the examined SNPs in the LTA genomic region and LGALS2 gene, or for haplotypes spanning the LTA genomic region. In two MI populations of European descent with markedly different ascertainment strategies, we were not able to identify a significant association of SNPs in the LTA genomic region or the LGALS2 gene with MI. These variants are unlikely to play a significant role in populations of European origin.
authors.affiliation: Klinik und Poliklinik für Innere Medizin II, Universitätsklinikum Regensburg, Franz-Josef-Strauss-Allee 11, 93053, Regensburg, Germany.
authors.forename: Kamil
authors.initials: K
authors.lastname: Sedlacek
authors.forename: Katharina
authors.initials: K
authors.lastname: Neureuther
authors.forename: Jakob C
authors.initials: JC
authors.lastname: Mueller
authors.forename: Klaus
authors.initials: K
authors.lastname: Stark
authors.forename: Marcus
authors.initials: M
authors.lastname: Fischer
authors.forename: Andrea
authors.initials: A
authors.lastname: Baessler
authors.forename: Wibke
authors.initials: W
authors.lastname: Reinhard
authors.forename: Ulrich
authors.initials: U
authors.lastname: Broeckel
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Lieb
authors.forename: Jeanette
authors.initials: J
authors.lastname: Erdmann
authors.forename: Heribert
authors.initials: H
authors.lastname: Schunkert
authors.forename: Günter
authors.initials: G
authors.lastname: Riegger
authors.forename: Thomas
authors.initials: T
authors.lastname: Illig
authors.forename: Thomas
authors.initials: T
authors.lastname: Meitinger
authors.forename: Christian
authors.initials: C
authors.lastname: Hengstenberg
mesh_terms: D000368:Aged; D004252:DNA Mutational Analysis; D005260:Female; D037501:Galectin 2 / Q000235:genetics*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D005858:Germany; D006239:Haplotypes; D006801:Humans; D008233:Lymphotoxin-alpha / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000208:ethnology / Q000235:genetics*; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D044465:White People / Q000235:genetics
chemical_list: D037501:Galectin 2; D008233:Lymphotoxin-alpha