Compound Hub: efficiency gains through innovative sample management processes.
While significant investments are made across the industry and increasingly also in academia to enhance or build a compound file, the efficient sourcing of compounds from in-house medical chemistry is frequently seen as a challenge. This article introduces the Compound Hub strategy developed at the Novartis Compound Archive. Central Compound Hubs in Basel and Cambridge were combined with web-based ordering of compounds and assays, providing assay-ready, solubilized samples to labs anywhere in the global research organization. Relieving scientists from time-intensive sample preparation tasks, error rates could be reduced through electronic processing and tracking of compounds/assays and the capture of medicinal chemistry compounds for the compound library could be increased by 75%.
Schopfer
Ulrich
U
Novartis Institutes for BioMedical Research, Discovery Technologies, Basel, Switzerland. ulrich.schopfer@novartis.com
Andreae
Marc R M
MR
Hueber
Matthieu
M
Saur
Andreas
A
Kummer
Marcel O
MO
Girod
Michel
M
Fox
Desmond
D
Steiner
Thomas
T
Popov
Maxim
M
Smith
Robert
R
D020650:Combinatorial Chemistry Techniques / Q000295:instrumentation* / Q000379:methods*; D017076:Computer-Aided Design; D016208:Databases, Factual; D004353:Drug Evaluation, Preclinical / Q000379:methods; D020407:Internet; D046609:Libraries, Digital