title: The relationship of dietary lipid intake and age-related macular degeneration in a case-control study: AREDS Report No. 20.
abstract: OBJECTIVE
  To evaluate the association of lipid intake with baseline severity of age-related macular degeneration (AMD) in the Age-Related Eye Disease Study (AREDS).
  
  
  METHODS
  Age-Related Eye Disease Study participants aged 60 to 80 years at enrollment (N = 4519) provided estimates of habitual nutrient intake through a self-administered semiquantitative food frequency questionnaire. Stereoscopic color fundus photographs were used to categorize participants into 4 AMD severity groups and a control group (participants with <15 small drusen).
  
  
  RESULTS
  Dietary total omega-3 long-chain polyunsaturated fatty acid (LCPUFA) intake was inversely associated with neovascular (NV) AMD (odds ratio [OR], 0.61; 95% confidence interval [CI], 0.41-0.90), as was docosahexaenoic acid, a retinal omega-3 LCPUFA (OR, 0.54; 95% CI, 0.36-0.80), comparing highest vs lowest quintile of intake, after adjustment for total energy intake and covariates. Higher fish consumption, both total and broiled/baked, was also inversely associated with NV AMD (OR, 0.61; 95% CI, 0.37-1.00 and OR, 0.65; 95% CI, 0.45-0.93, respectively). Dietary arachidonic acid was directly associated with NV AMD prevalence (OR, 1.54; 95% CI, 1.04-2.29). No statistically significant relationships existed for the other lipids or AMD groups.
  
  
  CONCLUSIONS
  Higher intake of omega-3 LCPUFAs and fish was associated with decreased likelihood of having NV AMD.
authors.affiliation: AREDS Coordinating Center, The EMMES Corporation, 401 N. Washington Street, Rockville, MD 20850, USA. aredspub@emmes.com
authors.forename: John Paul
authors.initials: JP
authors.lastname: SanGiovanni
authors.forename: Emily Y
authors.initials: EY
authors.lastname: Chew
authors.forename: Traci E
authors.initials: TE
authors.lastname: Clemons
authors.forename: Matthew D
authors.initials: MD
authors.lastname: Davis
authors.forename: Frederick L
authors.initials: FL
authors.lastname: Ferris
authors.forename: Gary R
authors.initials: GR
authors.lastname: Gensler
authors.forename: Natalie
authors.initials: N
authors.lastname: Kurinij
authors.forename: Anne S
authors.initials: AS
authors.lastname: Lindblad
authors.forename: Roy C
authors.initials: RC
authors.lastname: Milton
authors.forename: Johanna M
authors.initials: JM
authors.lastname: Seddon
authors.forename: Robert D
authors.initials: RD
authors.lastname: Sperduto
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D004032:Diet; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage*; D002149:Energy Intake; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage*; D005247:Feeding Behavior; D005260:Female; D006801:Humans; D008268:Macular Degeneration / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical; D016017:Odds Ratio; D011795:Surveys and Questionnaires
chemical_list: D004042:Dietary Fats, Unsaturated; D015525:Fatty Acids, Omega-3