Aromatic amino acid requirements in healthy human subjects.
Dietary aromatic amino acids are needed to meet the requirements for phenylalanine and tyrosine for protein synthesis. The amounts needed for neurotransmitter synthesis and other biological processes are small and quantitatively negligible. The earlier nitrogen balance-based estimates were judged to be inadequate. Very recently, there have been 3 estimates published based on the indicator amino acid oxidation technique, which average 42 mg.kg(-1).d(-1). This average value was obtained by feeding subjects a tyrosine-free diet and hence is an estimate of the mean maximum phenylalanine requirement. The mean minimum phenylalanine requirement estimate in the presence of an excess of tyrosine is 9.1 mg.kg(-1).d(-1). Hence, tyrosine can spare 78% of the dietary phenylalanine need. Finally the optimal proportions of dietary phenylalanine and tyrosine have been shown to be 60:40, respectively.
Pencharz
Paul B
PB
Research Institute, The Hospital for Sick Children, Ontario, Canada. paul.pencharz@sickkids.ca
Hsu
Jean W-C
JW
Ball
Ronald O
RO
D024322:Amino Acids, Aromatic / Q000378:metabolism*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D009751:Nutritional Requirements; D010649:Phenylalanine / Q000378:metabolism; D012016:Reference Values
D024322:Amino Acids, Aromatic; D010649:Phenylalanine