title: Can procalcitonin help us in timing of re-intervention in septic patients after multiple trauma or major surgery?
abstract: OBJECTIVE
  In surgical sepsis, the rapid identification of source of infection at an early stage after surgery or serious trauma is crucial for favorable outcome. The discrimination between local and generalized infection is critical for correct treatment.
  
  
  METHODS
  In a randomized, controlled, single-centre study we investigated 72 patients with severe sepsis after major abdominal surgery or surgery for multiple trauma. Patients were divided in 2 groups: in the first group (PCT, n=38), more important role in the treatment decision was given to PCT level (severe sepsis with PCT >2 ng/mL signalled bacteremia and pushed us to change antibiotics and intravascular devices, severe sepsis with PCT < or =2 ng/mL prompted use of ultrasonography and/or CT, followed by repeated surgery in patients with localized infection). The control group (CON, n=34) was treated by standard evaluation of all parameters by consultant surgeon. We investigated 28-day all-cause mortality, sepsis-related complications, the duration of stay in the intensive care unit, and ventilated days.
  
  
  RESULTS
  The hospital mortality was in PCT group 26% and 38% in control group (p = 0.28). Average SOFA score was 7.9 +/- 2.8 in PCT group vs. 9.3 +/- 3.3 (p = 0.06). The decline of ICU days (16.1 +/- 6.9 vs. 19.4 +/- 8.9; p = 0.09) and ventilated days (10.3 +/- 7.8 vs. 13.9 +/- 9.4; p = 0.08) in PCT group was observed, but the difference was not significant.
  
  
  CONCLUSIONS
  We observed a clear tendency to decrease extent of multiple organ dysfunction syndrome in patients, in which therapeutic decision was made earlier using procalcitonin as an additional marker separating local infection from generalized one.
authors.affiliation: Traumatological Hospital Brno, Research Center for Traumatology and Surgery, Brno. p.svoboda@unbr.cz
authors.forename: Petr
authors.initials: P
authors.lastname: Svoboda
authors.forename: Iona
authors.initials: I
authors.lastname: Kantorová
authors.forename: Peter
authors.initials: P
authors.lastname: Scheer
authors.forename: Jana
authors.initials: J
authors.lastname: Radvanova
authors.forename: Martin
authors.initials: M
authors.lastname: Radvan
mesh_terms: D000005:Abdomen / Q000601:surgery; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D002116:Calcitonin / Q000097:blood*; D015740:Calcitonin Gene-Related Peptide; D003428:Cross Infection / Q000401:mortality / Q000601:surgery*; D003661:Decision Support Techniques; D005260:Female; D006801:Humans; D015601:Injury Severity Score; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000175:diagnosis / Q000401:mortality / Q000601:surgery; D009104:Multiple Trauma / Q000401:mortality / Q000601:surgery*; D011183:Postoperative Complications / Q000401:mortality / Q000601:surgery*; D011237:Predictive Value of Tests; D011498:Protein Precursors / Q000097:blood*; D012086:Reoperation; D012121:Respiration, Artificial; D018805:Sepsis / Q000401:mortality / Q000601:surgery*
chemical_list: D015415:Biomarkers; C000606589:CALCA protein, human; D011498:Protein Precursors; D002116:Calcitonin; D015740:Calcitonin Gene-Related Peptide