Identification of the uncommon allele HLA-A*7403 in a Caucasian renal transplant cadaveric donor: extension of the exon 4 sequence.
This report describes the unknown exon 4 sequence of the rare A*7403 allele, identified in a Caucasian renal transplant cadaveric donor from Italy. This sequence is identical to that of the only known A*7401 exon 4, and this result allowed us to confirm the hypothesis of the generation of A*7403 allele from the ancestor A*7402 by point mutation in exon 2.
Canossi
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CNR Institute Organ Transplants and Immunocytology, L'Aquila, Italy. a.canossi@itoi.cnr.it
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Adorno
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D000483:Alleles; D000595:Amino Acid Sequence; D001483:Base Sequence; D004247:DNA / Q000235:genetics; D005091:Exons; D015234:HLA-A Antigens / Q000235:genetics*; D006801:Humans; D007558:Italy; D016030:Kidney Transplantation; D008969:Molecular Sequence Data; D017386:Sequence Homology, Amino Acid; D012689:Sequence Homology, Nucleic Acid; D014019:Tissue Donors; D044465:White People / Q000235:genetics
D015234:HLA-A Antigens; D004247:DNA