Secondary sea-blue histiocytosis derived from Niemann-Pick disease.
Sea-blue histiocytosis is a rare disorder seen in patients with lipid metabolic or ceroid storage diseases. Sea-blue histiocytes are ceroid-laden macrophages detectable by May-Giemsa staining. We report a case of a 28-year-old woman diagnosed with Niemann-Pick disease at 2 or 3 years of age. To confirm this diagnosis, we examined her bone marrow, which revealed scattered foci containing aggregates of foamy macrophages. May-Giemsa staining identified blue-staining foamy macrophages, referred to as sea-blue histiocytes. In summary, we report the detection of sea-blue histiocytosis in an adult with Niemann-Pick disease.
Suzuki
Osamu
O
First Department of Pathology, School of Medicine, Fukushima Medical University, Fukushima, Japan. osuzuki@fmu.ac.jp
Abe
Masafumi
M
D000328:Adult; D001854:Bone Marrow Cells / Q000473:pathology*; D001856:Bone Marrow Examination; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007962:Leukocytes / Q000201:enzymology; D008264:Macrophages / Q000473:pathology*; D009542:Niemann-Pick Diseases / Q000150:complications* / Q000175:diagnosis; D012618:Sea-Blue Histiocyte Syndrome / Q000175:diagnosis / Q000209:etiology*