Rostral anterior cingulate cortex activity in the theta band predicts response to antidepressive medication.
During the last 10 years the knowledge about rostral anterior cingulate cortex (ACC) activity in major depression has substantially increased. Several groups have independently described a relationship between resting activity in this area and response to antidepressant treatment. We have recently confirmed a relationship between resting activity of rostral ACC activity and response in a group of 20 patients with major depression using resting theta activity. In this earlier study regions of interest (ROI) were defined in order to establish regional specificity. Differences between responders and nonresponders were only found in the ACC-ROI, but not in the posterior cingulate region. We have now reanalyzed our data using a whole brain voxelwise approach, in order not to miss any other relevant functional differences. In addition to major differences between responders and nonresponders in the rostral ACC, we have identified a nearby region in the midline orbito-frontal region.
Mulert
Christoph
C
Department of Psychiatry, Ludwig-Maximilians-University, Munich, Germany. cmulert@med.uni-muenchen.de
Juckel
Georg
G
Brunnmeier
Michael
M
Karch
Susanne
S
Leicht
Gregor
G
Mergl
Roland
R
Möller
Hans-Jürgen
HJ
Hegerl
Ulrich
U
Pogarell
Oliver
O
D000928:Antidepressive Agents / Q000008:administration & dosage*; D003863:Depression / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology*; D004569:Electroencephalography / Q000187:drug effects* / Q000379:methods*; D005260:Female; D006179:Gyrus Cinguli / Q000187:drug effects / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care / Q000379:methods; D011379:Prognosis; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D016896:Treatment Outcome
D000928:Antidepressive Agents