Dengue has a benign presentation in renal transplant patients: a case series.
OBJECTIVE
Dengue fever and its complications are a poorly described entity in the renal transplant population. Previous reports in renal transplant patients suggest a high mortality rate.


METHODS
We undertook a retrospective study of six cases of dengue fever in renal transplant patients during a dengue outbreak in Singapore in 2005 which involved a total of 1400 cases in the city state.


RESULTS
Mean thrombocytopenia was 130,000/microL on presentation and 80,000/microL at deffervescence. No dengue haemorrhagic fever, dengue shock syndrome, deaths or abnormal graft function were observed. Mean hospital stay was 8.6 days. Four of six patients also had simultaneous CMV reactivation.


CONCLUSIONS
In common with the majority of adults, dengue fever follows a benign course in the renal transplant population and dengue haemorrhagic fever is rare. This may be related to the relative immunosuppression reducing the risk for antibody-enhanced complications.
Renaud
Claude Jeffrey
CJ
Division of Nephrology, Department of Medicine, National University Hospital, Singapore. claude_jeffrey_renaud@nuh.com.sg
Manjit
Kaur
K
Pary
Sivaraman
S
D000368:Aged; D003715:Dengue / Q000473:pathology*; D005260:Female; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000097:blood; D012189:Retrospective Studies; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012846:Singapore; D013921:Thrombocytopenia / Q000097:blood
D007075:Immunoglobulin M