title: [Immunogenicity of surface and capsular antigens of Burkholderia].
abstract: Study showed that five (C3, C6, C9, C10, C11) out of ten chromatographic fractions of surface and capsular antigens of B. mallei significantly stimulated cell-mediated immunity that manifested in activation of delayed hypersensivity reactions (DHS) and phagocyteability of noncapsulated avirulent strain of B. mallei with added surface and capsular antigenic complexes. Other fractions did not stimulate cell-mediated immunity, furthermore, fraction C8, which contained capsular biopolymer with mass of 200 kD (Ar8), was characterized by immunosuppressive effect on DHS and phagocytosis. Observed stimulation of cell-mediated immunity by fractions referred above has been confirmed by assessment of their protective effects on the model of experimental melioidosis in white rats. Relationship between markers of humoral and cell-mediated immunity, including markers of specific response, was not observed.
authors.forename: N N
authors.initials: NN
authors.lastname: Piven'
authors.forename: I V
authors.initials: IV
authors.lastname: Avrorova
authors.forename: S I
authors.initials: SI
authors.lastname: Zhukova
authors.forename: V V
authors.initials: VV
authors.lastname: Alekseev
authors.forename: N P
authors.initials: NP
authors.lastname: Khrapova
authors.forename: I I
authors.initials: II
authors.lastname: Korsakova
authors.forename: L V
authors.initials: LV
authors.lastname: Lomova
authors.forename: G M
authors.initials: GM
authors.lastname: Napalkova
authors.forename: I M
authors.initials: IM
authors.lastname: Drefs
authors.forename: O B
authors.initials: OB
authors.lastname: Proshina
mesh_terms: D000818:Animals; D016667:Bacterial Capsules / Q000276:immunology* / Q000302:isolation & purification; D001426:Bacterial Proteins / Q000276:immunology* / Q000302:isolation & purification; D001704:Biopolymers / Q000737:chemistry / Q000276:immunology; D042726:Burkholderia mallei / Q000276:immunology*; D006968:Hypersensitivity, Delayed; D007165:Immunosuppression Therapy; D008554:Melioidosis / Q000276:immunology / Q000517:prevention & control; D008565:Membrane Proteins / Q000276:immunology* / Q000302:isolation & purification; D051379:Mice; D008970:Molecular Weight; D010587:Phagocytosis / Q000276:immunology; D051381:Rats
chemical_list: D001426:Bacterial Proteins; D001704:Biopolymers; D008565:Membrane Proteins