A chronically implantable, hybrid cannula-electrode device for assessing the effects of molecules on electrophysiological signals in freely behaving animals.
We describe a device for assessing the effects of diffusible molecules on electrophysiological recordings from multiple neurons. This device allows for the infusion of reagents through a cannula located among an array of micro-electrodes. The device can easily be customized to target specific neural structures. It is designed to be chronically implanted so that isolated neural units and local field potentials are recorded over the course of several weeks or months. Multivariate statistical and spectral analysis of electrophysiological signals acquired using this system could quantitatively identify electrical "signatures" of therapeutically useful drugs.
Greger
Bradley
B
University of Utah, Department of Bioengineering, Salt Lake City, UT 84112, United States. bradley.greger@utah.edu
Kateb
Babak
B
Gruen
Peter
P
Patterson
Paul H
PH
D000200:Action Potentials / Q000187:drug effects / Q000502:physiology; D000818:Animals; D001522:Behavior, Animal; D001921:Brain / Q000187:drug effects / Q000502:physiology; D002404:Catheterization / Q000295:instrumentation* / Q000379:methods; D004353:Drug Evaluation, Preclinical / Q000379:methods; D004567:Electrodes, Implanted; D004594:Electrophysiology / Q000295:instrumentation* / Q000379:methods; D015918:Infusion Pumps, Implantable / Q000592:standards; D009068:Movement; D009474:Neurons / Q000187:drug effects / Q000502:physiology; D009480:Neuropharmacology / Q000295:instrumentation* / Q000379:methods; D051381:Rats; D012815:Signal Processing, Computer-Assisted