Kinase clamping.
By introducing two point mutations in the ATP-binding pockets of kinases, researchers can specifically and irreversibly inhibit these enzymes and determine how much kinase activity is needed for downstream signaling.
Rusk
Nicole
N
D003545:Cysteine / Q000235:genetics; D010770:Phosphotransferases / Q000037:antagonists & inhibitors* / Q000235:genetics; D017354:Point Mutation; D011799:Quinazolines / Q000494:pharmacology
D011799:Quinazolines; D010770:Phosphotransferases; D003545:Cysteine