title: Are there common human leucocyte antigen associations in juvenile idiopathic arthritis and periodontitis?
abstract: OBJECTIVE
  The aim of this study was to evaluate common human leucocyte antigen (HLA) associations in patients with juvenile idiopathic arthritis (N=110), in patients with generalized aggressive periodontitis (N=50) and in patients with chronic periodontitis (N=102) in comparison to healthy controls (no periodontitis, no arthritis N=102).
  
  
  METHODS
  HLA-class I and II markers were determined using microlymphocytotoxicity test and polymerase chain reaction with sequence specific primers. Statistical analyses were carried out by chi(2)-test and Yates' correction. If n<5 Fisher's exact test was performed. In the arthritis group the influence of HLA on attachment loss was determined by using backwards logistic regression considering age, gender, smoking, plaque level, and the duration of the disease.
  
  
  RESULTS
  In comparison with the controls HLA-DRB3(*) occurred more frequently in both females suffering from juvenile idiopathic arthritis (74.58%versus 54.54%, p=0.024) and females suffering from chronic periodontitis (73.02%versus 54.54%, p=0.035). Furthermore, among patients with juvenile idiopathic arthritis an increased odds ratio (OR) for attachment loss was found in subjects who expressed HLA-A(*)01 (OR=4.6, p=0.014) or HLA-A(*)01:DRB3(*) (OR=4.3, p=0.031).
  
  
  CONCLUSIONS
  HLA-DRB3(*) could be a common putative risk indicator for juvenile idiopathic arthritis and chronic periodontitis among females.
authors.affiliation: University School of Dental Medicine, Department of Operative Dentistry and Periodontology, Martin-Luther University, Halle-Wittenberg, Germany. stefan.reichert@medizin.uni-halle.de
authors.forename: Stefan
authors.initials: S
authors.lastname: Reichert
authors.forename: Jamal
authors.initials: J
authors.lastname: Stein
authors.forename: Corinna
authors.initials: C
authors.lastname: Fuchs
authors.forename: Vera
authors.initials: V
authors.lastname: John
authors.forename: Hans-Günter
authors.initials: HG
authors.lastname: Schaller
authors.forename: Helmut K G
authors.initials: HK
authors.lastname: Machulla
mesh_terms: D000293:Adolescent; D000328:Adult; D001171:Arthritis, Juvenile / Q000276:immunology*; D002648:Child; D002908:Chronic Disease; D015331:Cohort Studies; D005260:Female; D005787:Gene Frequency; D015236:HLA-C Antigens / Q000032:analysis; D006684:HLA-DR Antigens / Q000032:analysis; D059811:HLA-DRB1 Chains; D059826:HLA-DRB3 Chains; D015395:Histocompatibility Antigens Class I / Q000032:analysis* / Q000235:genetics; D000949:Histocompatibility Antigens Class II / Q000032:analysis* / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D017622:Periodontal Attachment Loss / Q000276:immunology; D010518:Periodontitis / Q000276:immunology*; D010519:Periodontium / Q000276:immunology; D010641:Phenotype; D012307:Risk Factors; D012907:Smoking
chemical_list: D015236:HLA-C Antigens; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; C456920:HLA-DRB1*07 antigen; C507799:HLA-DRB1*15 antigen; D059826:HLA-DRB3 Chains; D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II