title: A clinical report of bone regeneration in maxillofacial surgery using bonelike synthetic bone graft.
abstract: The objective of this study is to evaluate the osteoconductivity and bioactivity of the Bonelike graft in repairing surgical cystic bone defects. Bonelike is implanted in 11 patients, aged between 24 and 53 years with a mean age of 36 years, consisting of 5 men and 6 women. According to the standard follow up protocols, radiological examinations are performed and Bonelike/bone retrieved samples have been analyzed histologically using non-decalcified sections obtained perpendicular to bone length axis. Radiographic examination and histological results clearly demonstrate an extensive new bone formation apposed on Bonelike granules with a significant degree of maturation. These clinical applications in maxillary bone defects indicate perfect bone bonding between new bone formed and Bonelike granules, along with partial surface biodegradation. This quick and effective osteoconductive response from Bonelike may reduce the time needed to reconstruct the bone defected area of patients.
authors.affiliation: Serviço de Estomatologia e Cirurgia Maxilofacial, Hospital Geral de Santo António, Largo Abel Salazar, 4050, Porto, Portugal.
authors.forename: R C
authors.initials: RC
authors.lastname: Sousa
authors.forename: J V
authors.initials: JV
authors.lastname: Lobato
authors.forename: A C
authors.initials: AC
authors.lastname: Maurício
authors.forename: N S
authors.initials: NS
authors.lastname: Hussain
authors.forename: C M
authors.initials: CM
authors.lastname: Botelho
authors.forename: M A
authors.initials: MA
authors.lastname: Lopes
authors.forename: J D
authors.initials: JD
authors.lastname: Santos
mesh_terms: D000328:Adult; D018786:Bone Substitutes / Q000627:therapeutic use*; D016025:Bone Transplantation / Q000295:instrumentation* / Q000379:methods; D005147:Facial Bones / Q000473:pathology* / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012038:Regeneration; D013515:Surgery, Oral / Q000295:instrumentation* / Q000379:methods; D016896:Treatment Outcome
chemical_list: D018786:Bone Substitutes