Comparison of two versions of the IDI-MRSA assay using charcoal swabs for prospective nasal and nonnasal surveillance samples.
An updated IDI-MRSA assay version was released to address the assay's low positive predictive value (PPV). A prospective analysis of two assay versions indicated no significant improvement in the PPV. Colonization by methicillin-resistant Staphylococcus aureus in 24% of patients would not have been detected if only nasal samples had been tested, as approved, by this molecular method.
Zhang
Sean X
SX
Department of Laboratory Medicine and Pathobiology, University of Toronto, Canada.
Drews
Steven J
SJ
Tomassi
Joanne
J
Katz
Kevin C
KC
D015373:Bacterial Typing Techniques; D002353:Carrier State / Q000382:microbiology; D002606:Charcoal; D006801:Humans; D016106:Methicillin Resistance; D009666:Nose / Q000382:microbiology*; D011159:Population Surveillance; D011933:Reagent Kits, Diagnostic; D012007:Rectum / Q000382:microbiology; D012680:Sensitivity and Specificity; D013048:Specimen Handling; D013203:Staphylococcal Infections / Q000453:epidemiology; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000302:isolation & purification*
D011933:Reagent Kits, Diagnostic; D002606:Charcoal