Comparison of group testing algorithms for case identification in the presence of test error.
We derive and compare the operating characteristics of hierarchical and square array-based testing algorithms for case identification in the presence of testing error. The operating characteristics investigated include efficiency (i.e., expected number of tests per specimen) and error rates (i.e., sensitivity, specificity, positive and negative predictive values, per-family error rate, and per-comparison error rate). The methodology is illustrated by comparing different pooling algorithms for the detection of individuals recently infected with HIV in North Carolina and Malawi.
Kim
Hae-Young
HY
Department of Biostatistics, School of Public Health, University of North Carolina at Chapel Hill, 3107-E McGavran-Greenberg Hall, Chapel Hill, North Carolina 27599, USA.
Hudgens
Michael G
MG
Dreyfuss
Jonathan M
JM
Westreich
Daniel J
DJ
Pilcher
Christopher D
CD
D000465:Algorithms; D016477:Artifacts; D001699:Biometry / Q000379:methods; D003627:Data Interpretation, Statistical; D015658:HIV Infections / Q000175:diagnosis* / Q000453:epidemiology*; D006801:Humans; D008295:Malawi / Q000453:epidemiology; D008403:Mass Screening / Q000379:methods*; D009657:North Carolina / Q000453:epidemiology; D011159:Population Surveillance / Q000379:methods*; D015995:Prevalence; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity