title: Discrepancies in Gleason scoring of prostate biopsies and radical prostatectomy specimens and the effects of multiple needle biopsies on scoring accuracy. A regional experience in Tamworth, Australia.
abstract: BACKGROUND
  The aim of this study was to review the discrepancies in Gleason scores (GS) of prostate biopsies and radical prostatectomy specimens and the effects of multiple-needle biopsies on scoring accuracy.
  
  
  METHODS
  One hundred patients who had undergone consecutive radical prostatectomies (RP) between January 2004 and May 2006 were reviewed retrospectively. Patient information including age, prebiopsy prostate-specific antigen levels, biopsy GS, RP GS and pathology details were recorded and compared.
  
  
  RESULTS
  The concordance rate of biopsy GS and RP GS was found to be at 43%, with 46% of biopsy specimens being undergraded. Eleven per cent of the specimens were overgraded. The accuracy was fairly similar when specimens were reported by the same or different pathologists, at 42 and 44%, respectively. The accuracy of biopsy GS improved with increasing number of biopsies taken.
  
  
  CONCLUSIONS
  There are significant discrepancies in Gleason scoring of biopsy and RP specimens, with a concordance rate of 43% and undergrading rate of 46%. Increasing the number of biopsies helps improve scoring accuracy. Clinicians and patients need to be mindful when deciding cancer treatment options, in view of these discrepancies.
authors.affiliation: Tamworth Base Hospital, Urology, Tamworth, New South Wales, Australia. kck_ooi@yahoo.com
authors.forename: Kevin
authors.initials: K
authors.lastname: Ooi
authors.forename: Ramin
authors.initials: R
authors.lastname: Samali
mesh_terms: D000368:Aged; D001315:Australia; D001707:Biopsy, Needle / Q000592:standards*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011467:Prostate / Q000473:pathology*; D011468:Prostatectomy; D012189:Retrospective Studies