title: Sol-gel-derived TiO(2)-SiO (2) implant coatings for direct tissue attachment. Part I: design, preparation and characterization.
abstract: A series of sol-gel derived TiO(2)-SiO(2) mixed oxide coatings were prepared by carefully controlling the process parameters to obtain silica-releasing coatings consisting of nanoparticles. These features are of paramount importance for enhanced cell adhesion and activation. To achieve both these goals the Ti-alkoxide and Si-alkoxide were first separately hydrolysed and the titania-silica mixed sol was further reacted before the dipping process to obtain the desired particle sizes resulting to the biologically favourable topographical features. Silica release was observed from all the prepared coatings and it was dependent on SiO(2) amount added to the sols, i.e., the higher the added amount the higher the release. In addition, calcium phosphate was able to nucleate on the coatings. From the obtained SiO(2) dissolution data, together with the detailed XPS peak analysis, the mixed oxide coatings are concluded to be chemically heterogeneous, consisting of TiO(2) and SiO(2) species most likely linked together by Ti-O-Si bonds. TiO(2) is chemically stable making long-term implant coating possible and the desired nanoscale dimensions were well preserved although the composition was changed as a consequence of SiO(2) dissolution under in vitro conditions.
authors.affiliation: Department of Prosthetic Dentistry and Biomaterials Research, Institute of Dentistry, University of Turku, Lemminkäisenkatu 2, 20520, Turku, Finland.
authors.forename: Virpi
authors.initials: V
authors.lastname: Aäritalo
authors.forename: Sami
authors.initials: S
authors.lastname: Areva
authors.forename: Mika
authors.initials: M
authors.lastname: Jokinen
authors.forename: Mika
authors.initials: M
authors.lastname: Lindén
authors.forename: Timo
authors.initials: T
authors.lastname: Peltola
mesh_terms: D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D005782:Gels; D008422:Materials Testing; D018625:Microscopy, Atomic Force; D008855:Microscopy, Electron, Scanning; D053758:Nanoparticles / Q000737:chemistry; D010316:Particle Size; D019736:Prostheses and Implants; D012822:Silicon Dioxide / Q000737:chemistry*; D013057:Spectrum Analysis; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry*; D014961:X-Ray Diffraction; D014965:X-Rays
chemical_list: D020099:Coated Materials, Biocompatible; D005782:Gels; C009495:titanium dioxide; D012822:Silicon Dioxide; D014025:Titanium