title: Insulin-degrading enzyme is genetically associated with Alzheimer's disease in the Finnish population.
abstract: The gene for insulin-degrading enzyme (IDE), which is located at chromosome 10q24, has been previously proposed as a candidate gene for late-onset Alzheimer's disease (AD) based on its ability to degrade amyloid beta-protein. Genotyping of single nucleotide polymorphisms (SNPs) in the IDE gene in Finnish patients with AD and controls revealed SNPs rs4646953 and rs4646955 to be associated with AD, conferring an approximately two-fold increased risk. Single locus findings were corroborated by the results obtained from haplotype analyses. This suggests that genetic alterations in or near the IDE gene may increase the risk for developing AD.
authors.forename: Saila
authors.initials: S
authors.lastname: Vepsäläinen
authors.forename: Michele
authors.initials: M
authors.lastname: Parkinson
authors.forename: Seppo
authors.initials: S
authors.lastname: Helisalmi
authors.forename: Arto
authors.initials: A
authors.lastname: Mannermaa
authors.forename: Hilkka
authors.initials: H
authors.lastname: Soininen
authors.forename: Rudolph E
authors.initials: RE
authors.lastname: Tanzi
authors.forename: Lars
authors.initials: L
authors.lastname: Bertram
authors.forename: Mikko
authors.initials: M
authors.lastname: Hiltunen
mesh_terms: D000328:Adult; D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000453:epidemiology / Q000235:genetics*; D053327:Apolipoprotein E4 / Q000235:genetics; D015331:Cohort Studies; D005260:Female; D005387:Finland / Q000453:epidemiology; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D007339:Insulysin / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012306:Risk
chemical_list: D053327:Apolipoprotein E4; D007339:Insulysin