Camellia oil and its distillate fractions effectively inhibit the spontaneous metastasis of mouse melanoma BL6 cells.
We previously reported that daily intraperitoneal injections of oleamide weakly inhibits the spontaneous metastasis of BL6 cells by blocking the gap junction-mediated intercellular communications (GJIC) of connexin 26 (Cx26). In the present study, we tested camellia oil, olive oil and cottonseed oil which are rich in oleamide-like oleic acid for their inhibitory potency on Cx26-mediated GJIC and spontaneous metastasis of BL6 cells. We found that camellia oil, olive oil and cottonseed oil, and their distillate fractions inhibited Cx26-mediated GJIC. We also showed that daily intraperitoneal injection of camellia oil and its distillate fractions more potently inhibited spontaneous lung metastasis of BL6 cells than oleamide. Moreover, a daily oral administration of camellia oil distillate fraction effectively inhibited spontaneous metastasis. Notably, even camellia Tempura-oil, a commercially available food, weakly inhibited the spontaneous metastasis of BL6 cells. Since these oils are used as foods and are quite safe, we propose that they could be used as supplements to protect patients from lung metastasis of melanomas.
Miura
Daisaku
D
Biosafety Research Center for Foods, Drugs and Pesticides, Iwata, Shizuoka 437-1213, Japan.
Kida
Yoshishige
Y
Nojima
Hiroshi
H
D000818:Animals; D028244:Camellia; D045744:Cell Line, Tumor; D003369:Cottonseed Oil / Q000494:pharmacology; D017629:Gap Junctions / Q000187:drug effects / Q000502:physiology; D008545:Melanoma / Q000473:pathology*; D051379:Mice; D009362:Neoplasm Metastasis / Q000517:prevention & control*; D000069463:Olive Oil; D008517:Phytotherapy; D010938:Plant Oils / Q000737:chemistry / Q000494:pharmacology*
D003369:Cottonseed Oil; D000069463:Olive Oil; D010938:Plant Oils