Neuropsychological patterns in systemic lupus erythematosus patients with depression.
Thirteen patients with systemic lupus erythematosus and depression (Depressed-SLE), 10 Depressed-Control subjects, and 25 Healthy Control subjects completed cognitive testing and self-report questionnaires of pain, depression, and fatigue. The Depressed-SLE group scored higher on the American College of Rheumatology Neuropsychological Battery for systemic lupus erythematosus cognitive impairment index compared to Depressed-Control and Healthy Control subjects (p < 0.05 and p < 0.02, respectively). No correlations between cognitive impairment and pain, fatigue, or perceived cognitive failures were observed in the Depressed-SLE participants. Moderate agreement (86.4%) was found between a comprehensive neuropsychology battery cognitive impairment index and the ACR-SLE impairment index in the Depressed-SLE patients. Overall, the magnitude and pattern of cognitive impairment in Depressed-SLE patients cannot be explained by depression alone.
Kozora
Elizabeth
E
Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson St, Denver, CO 80206, USA. kozorae@njc.org
Arciniegas
David B
DB
Zhang
Lening
L
West
Sterling
S
D000328:Adult; D003072:Cognition Disorders / Q000453:epidemiology / Q000209:etiology*; D003863:Depression / Q000150:complications*; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000523:psychology; D020945:Lupus Vasculitis, Central Nervous System / Q000150:complications / Q000523:psychology; D008297:Male; D009483:Neuropsychological Tests