Effect of brain-dead donor resuscitation on delayed graft function: results of a monocentric analysis.
BACKGROUND
We have previously shown that a delayed graft function (DGF) longer than 6 days was a crucial threshold for long-term graft outcome. The aim of this study was to analyze the correlation of DGF >or=6 days with brain-dead donor variables, including those related to resuscitation, in a population of 262 consecutive brain-dead donors from 1990 to 2003.


METHODS
We used a marginal logistic model in which DGF was considered as a binary variable with a cutoff of 6 days.


RESULTS
Monovariate analysis of donor parameters showed that male, age above 35 years, primary history of hypertension, hydroxyethyl starch (HES) fluid greater than 1500 mL or epinephrine infusion during resuscitation were risk factors for prolonged DGF. The multivariate logistic regression model showed that epinephrine use during donor resuscitation (P<0.001, odds ratio [OR]=4.35), cold ischemia time (CIT) >or=16 hr (P=0.01, OR=2.16), and recipient age >55 years (P=0.003, OR=2.75), were associated with a risk of prolonged DGF. A long stay (>40 hr) in intensive care and a large volume of colloids (>1250 mL, except HES) correlated with a lower risk of DGF.


CONCLUSIONS
Our study shows an impact for only a limited number of brain dead donor resuscitation parameters on DGF duration. We also show that CIT has a much lower threshold (<16 hr) for DGF risk than previously described. Importantly, we show that recipient age is clearly a major independent risk factor for prolonged DGF, whereas donor age seems to act mostly as a dependent risk factor.
Giral
Magali
M
Institut de Transplantation Et de Recherche en Transplantation and INSERM U643, Immunointervention dans les Allo et Xénotransplantation, Nantes, France.
Bertola
Jean Pierre
JP
Foucher
Yohann
Y
Villers
Daniel
D
Bironneau
Evelyne
E
Blanloeil
Yvonnick
Y
Karam
Georges
G
Daguin
Pascal
P
Lerat
Lydie
L
Soulillou
Jean Paul
JP
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001926:Brain Death; D002648:Child; D002675:Child, Preschool; D050377:Cold Ischemia; D051799:Delayed Graft Function / Q000209:etiology*; D004837:Epinephrine / Q000009:adverse effects / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006895:Hydroxyethyl Starch Derivatives / Q000009:adverse effects / Q000627:therapeutic use; D006973:Hypertension / Q000150:complications; D007674:Kidney Diseases / Q000150:complications / Q000601:surgery; D016030:Kidney Transplantation; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012151:Resuscitation / Q000009:adverse effects* / Q000379:methods; D012189:Retrospective Studies; D012307:Risk Factors; D012737:Sex Factors; D013997:Time Factors; D014019:Tissue Donors
D006895:Hydroxyethyl Starch Derivatives; D004837:Epinephrine