title: Beneficial effects of the extract from Corydalis yanhusuo in rats with heart failure following myocardial infarction.
abstract: As indicated in ancient Chinese medical books, Corydalis yanhusuo has therapeutic effects on cardiovascular diseases. The analgesic effect of this plant has been fully elucidated, and l-tetrahydropalmatine has been shown to be the main active principle. The aim of this investigation was to evaluate its protective effects in a rat heart failure model. Rats were subjected to coronary artery ligation, and orally administered with ethanolic extract of Corydalis yanhusuo 50, 100, or 200 mg kg(-1) daily, from the 7th day after surgery. We measured cardiac function, plasma atrial natriuretic peptide (ANP), relative heart and lung weights, infarct size and ventricular dilatation after treatment for 8 weeks. Administration with Corydalis yanhusuo led to a significant reduction in infarct size and improvement in cardiac function as demonstrated by lower left ventricular end diastolic pressure (LVEDP) and elevated +/-dp/dt(max). We also found that Corydalis yanhusuo significantly reduced left ventricular (LV)/body weight ratio, lung/body weight ratio and significantly inhibited neurohormonal activation. Taken together, this study indicated that Corydalis yanhusuo exerted salutary effects on heart failure induced by myocardial infarction in rats.
authors.affiliation: Department of Pharmacology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, P R China. wulimao@yahoo.com.cn
authors.forename: Limao
authors.initials: L
authors.lastname: Wu
authors.forename: Haiyun
authors.initials: H
authors.lastname: Ling
authors.forename: Lianda
authors.initials: L
authors.lastname: Li
authors.forename: Lianxiu
authors.initials: L
authors.lastname: Jiang
authors.forename: Minle
authors.initials: M
authors.lastname: He
mesh_terms: D000818:Animals; D009320:Atrial Natriuretic Factor / Q000097:blood; D001794:Blood Pressure / Q000187:drug effects; D002303:Cardiac Output, Low / Q000188:drug therapy* / Q000209:etiology; D002316:Cardiotonic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D003331:Coronary Vessels; D031311:Corydalis; D004108:Dilatation, Pathologic / Q000188:drug therapy; D004305:Dose-Response Relationship, Drug; D006321:Heart / Q000187:drug effects; D006334:Heart Function Tests; D008026:Ligation; D008168:Lung / Q000187:drug effects; D008297:Male; D009203:Myocardial Infarction / Q000150:complications*; D009929:Organ Size / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D010946:Plants, Medicinal; D051381:Rats; D017207:Rats, Sprague-Dawley; D027343:Rhizome
chemical_list: D002316:Cardiotonic Agents; D010936:Plant Extracts; D009320:Atrial Natriuretic Factor