Update of the medical treatment of West syndrome.
West syndrome is a generalized epilepsy syndrome composed of infantile spasms and onset is usually within the first year of life. Although West syndrome is well known clinical epileptic syndrome, there is no agreement about the first- and second-line treatments. In the last years a great progress in the development of new antiepileptic drugs allow us to have a large choice of treatment options to control the seizures. This review outlines the usefulness of the different antiepileptic drugs for the treatment of West syndrome.
Verrotti
A
A
Department of Pediatrics, University of Chieti, Chieti, Italy. averrott@unich.it
Manco
R
R
Coppola
G G
GG
Mingione
S
S
Chiarelli
F
F
Iannetti
P
P
D000324:Adrenocorticotropic Hormone / Q000627:therapeutic use; D000927:Anticonvulsants / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D004569:Electroencephalography; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007223:Infant; D011241:Prednisone / Q000627:therapeutic use; D013036:Spasms, Infantile / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D016896:Treatment Outcome; D014635:Valproic Acid / Q000627:therapeutic use; D020888:Vigabatrin / Q000627:therapeutic use; D025101:Vitamin B 6 / Q000627:therapeutic use
D000927:Anticonvulsants; D005938:Glucocorticoids; D014635:Valproic Acid; D025101:Vitamin B 6; D000324:Adrenocorticotropic Hormone; D020888:Vigabatrin; D011241:Prednisone