title: Synthesis and biodistribution of 8-iodo-11-(4-methylpiperazino)-5H-dibenzo[b,e][1,4]-diazepine: Iozapine.
abstract: 8-Iodo-11-(4-methylpiperazino)-5H-dibenzo[b,e][1,4]-diazepine: Iozapine, a potential D(4)-receptor ligand was synthesized using oxidative iodo-destannylation reaction. The preliminary biodistribution studies of radioiodinated iozapine have shown that the compound is taken up in the brains of mice and rabbits.
authors.affiliation: Department of Oncology, University of Alberta, 11560 University Avenue, Edmonton, Alberta, Canada T6G 1Z2. alummott@cancerboard.ab.ca
authors.forename: Alummoottil V
authors.initials: AV
authors.lastname: Joshua
authors.forename: Sanjay K
authors.initials: SK
authors.lastname: Sharma
authors.forename: Alicia
authors.initials: A
authors.lastname: Strelkov
authors.forename: John R
authors.initials: JR
authors.lastname: Scott
authors.forename: Mathew T
authors.initials: MT
authors.lastname: Martin-Iverson
authors.forename: Douglas N
authors.initials: DN
authors.lastname: Abrams
authors.forename: Peter H
authors.initials: PH
authors.lastname: Silverstone
authors.forename: Alexander J B
authors.initials: AJ
authors.lastname: McEwan
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D003024:Clozapine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000378:metabolism / Q000493:pharmacokinetics; D051379:Mice; D011817:Rabbits; D050638:Receptors, Dopamine D4 / Q000378:metabolism; D014018:Tissue Distribution
chemical_list: C522904:iozapine; D050638:Receptors, Dopamine D4; D003024:Clozapine