Fibroblast growth factor 20 gene and Parkinson's disease in the Japanese population.
A genetic association between the fibroblast growth factor 20 (FGF20) gene and Parkinson's disease has been found by the pedigree disequilibrium test. This association, however, was not replicated by a case-control association study. In order to clarify the association between the FGF20 gene and Parkinson's disease, we attempted to replicate this association by a case-control association study using a large number of Japanese samples (1388 patients and 1891 controls). rs1721100 exhibited a significant difference in allele C versus G (P=0.0089), and in genotype CC+CG versus GG (P=0.0053). Haplotype association analysis showed that haplotype 2 was the protective haplotype for Parkinson's disease (permutation-P=0.0075). These results suggest that the FGF20 gene is a susceptibility gene for Parkinson's disease in the Japanese population.
Satake
Wataru
W
Division of Clinical Genetics, Department of Medical Genetics, Osaka University Graduate School of Medicine, Yamadaoka, Suita, Osaka, Japan.
Mizuta
Ikuko
I
Suzuki
Satoko
S
Nakabayashi
Yuko
Y
Ito
Chiyomi
C
Watanabe
Masahiko
M
Takeda
Atsushi
A
Hasegawa
Kazuko
K
Sakoda
Saburo
S
Yamamoto
Mitsutoshi
M
Hattori
Nobutaka
N
Murata
Miho
M
Toda
Tatsushi
T
D000368:Aged; D000483:Alleles; D016022:Case-Control Studies; D005260:Female; D005346:Fibroblast Growth Factors / Q000235:genetics*; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D007564:Japan / Q000453:epidemiology; D015810:Linkage Disequilibrium / Q000235:genetics; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000453:epidemiology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012306:Risk
D005346:Fibroblast Growth Factors