Trypanosoma cruzi: adhesion to the host cell and intracellular survival.
Both invasion of the host cell by T. cruzi and its establishment into the mammalian host are critical steps. In this review, the adhesion step and the intracellular survival in non-professional phagocytes are particularly focused on, with special emphasis on the role of Gp85/trans-sialidase (Gp85/TS) superfamily. Excellent reviews have been published lately, some covering other aspects of T. cruzi-host interaction and will be cited instead of the original articles due to limited number of listed references.
Alves
Maria Júlia M
MJ
Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo, Brazil. mjmalves@iq.usp.br
Colli
Walter
W
D000818:Animals; D002448:Cell Adhesion / Q000502:physiology*; D002470:Cell Survival / Q000502:physiology*; D014355:Chagas Disease / Q000276:immunology / Q000382:microbiology; D006790:Host-Parasite Interactions; D006801:Humans; D010447:Peptide Hydrolases / Q000378:metabolism; D015800:Protozoan Proteins / Q000378:metabolism; D014349:Trypanosoma cruzi / Q000378:metabolism / Q000472:pathogenicity; D014643:Variant Surface Glycoproteins, Trypanosoma / Q000378:metabolism
D015800:Protozoan Proteins; D014643:Variant Surface Glycoproteins, Trypanosoma; D010447:Peptide Hydrolases