title: [Helicobacter pylori infection and GERD].
abstract: Helicobacter pylori (H. pylori) is an important pathogen that is known to be associated with gastritis, peptic ulcer diseases, and gastric cancer. The association between H. pylori infection and gastro-esophageal reflux disease (GERD) is, however, uncertain. Recent studies indicate that the prevalence of H. pylori is significantly lower in patient with GERD from East Asia than in patients from Western Europe and North America, and that H. pylori might protect against GERD. The frequency of hypochlorhydria might due to atrophic gastritis induced by H. pylori infection is associated with the low prevalence of GERD in Japan.
authors.affiliation: Division of Gastroenterology, Kawasaki Medical School.
authors.forename: Ken
authors.initials: K
authors.lastname: Haruma
authors.forename: Noriaki
authors.initials: N
authors.lastname: Manabe
authors.forename: Tomoari
authors.initials: T
authors.lastname: Kamada
authors.forename: Akiko
authors.initials: A
authors.lastname: Shiotani
authors.forename: Katsuyasu
authors.initials: K
authors.lastname: Kusaka
mesh_terms: D000375:Aging / Q000473:pathology / Q000502:physiology; D049630:Esophageal Sphincter, Lower / Q000503:physiopathology; D005744:Gastric Acid / Q000378:metabolism; D005753:Gastric Mucosa / Q000378:metabolism / Q000473:pathology; D005764:Gastroesophageal Reflux / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology / Q000517:prevention & control; D016481:Helicobacter Infections / Q000453:epidemiology / Q000503:physiopathology; D016480:Helicobacter pylori; D006801:Humans