title: Solubility of selected derivatives of 1,4-benzodiazepin-2-one in solid dispersions in PEG 6000.
abstract: Pharmaceutical availability of diazepam, oxazepam and nitrazepam from solid dispersions of PEG 6000 have been studied in comparison with corresponding physical mixtures and pure benzodiazepines. Selected derivatives of 1,4-benzodiazepin-2-one are poorly water soluble drugs. The aim of this work was to report the properties of diazepam- and nitrazepam-PEG 6000 solid dispersions. Differential scanning calorimetry (DSC) and X-ray diffraction were used to characterize the solid dispersions. The effect of PEG 6000 on the dissolution of selected derivatives of 1,4-benzodiazepin-2-one was investigated. The dissolution of diazepam, oxazepam and nitrazepam from its solid dispersions increased in the presence of PEG 6000.
authors.affiliation: Poznań University of Medical Sciences, Department of Inorganic and Analytical Chemistry 6 Grunwaldzka Street, 60-780 Poznań, Poland.
authors.forename: Barbara
authors.initials: B
authors.lastname: Cwiertnia
mesh_terms: D001570:Benzodiazepinones / Q000737:chemistry* / Q000493:pharmacokinetics; D002152:Calorimetry, Differential Scanning / Q000379:methods; D011092:Polyethylene Glycols / Q000737:chemistry* / Q000493:pharmacokinetics; D012995:Solubility; D013678:Technology, Pharmaceutical / Q000379:methods; D014961:X-Ray Diffraction / Q000379:methods
chemical_list: D001570:Benzodiazepinones; D011092:Polyethylene Glycols