Dietary fats induce human monocyte activation in vitro.
In early atherosclerosis the frequency of activated monocytes in the peripheral circulation is amplified, and migration of monocytes into the walls of the aorta and large arteries is increased, due partly to de novo expression or activation of monocyte adhesion molecules. Although there is increasing evidence that CMRs (chylomicron remnants) are strongly atherogenic, the outcomes of interactions between blood monocytes and circulating CMRs are not known. Here, we have studied the effects of CRLPs (CMR-like particles) on THP-1 human monocyte oxidative burst. The particles induced a significant increase in reactive oxygen species within 1 h, which persisted for 24 h. We suggest that monocyte-CMR interactions may be important in early atherosclerosis when many activated monocytes are found in susceptible areas of the artery wall.
Bentley
C
C
Veterinary Basic Sciences, The Royal Veterinary College, Royal College Street, London NW1 0TU, UK.
Bejta
F
F
De Pascale
C
C
Avella
M
M
Wheeler-Jones
C P D
CP
Botham
K M
KM
Lawson
C
C
D050197:Atherosclerosis / Q000097:blood / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D002460:Cell Line; D053298:Chylomicron Remnants / Q000097:blood / Q000378:metabolism / Q000502:physiology; D004041:Dietary Fats / Q000009:adverse effects / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D008055:Lipids / Q000097:blood; D009000:Monocytes / Q000187:drug effects* / Q000473:pathology / Q000502:physiology; D017382:Reactive Oxygen Species / Q000378:metabolism
D053298:Chylomicron Remnants; D004041:Dietary Fats; D008055:Lipids; D017382:Reactive Oxygen Species