title: QseA and GrlR/GrlA regulation of the locus of enterocyte effacement genes in enterohemorrhagic Escherichia coli.
abstract: Transcription of the locus of enterocyte effacement (LEE) genes in enterohemorrhagic Escherichia coli (EHEC) is regulated by the LEE-encoded Ler and GrlR/GrlA proteins as well as the non-LEE-encoded regulator QseA. This work demonstrates that GrlR/GrlA activate LEE2 transcription in a Ler-independent fashion, whereas transcription of grlRA is activated by QseA in both Ler-dependent and -independent manners.
authors.affiliation: University of Texas Southwestern Medical Center, Department of Microbiology, Dallas, TX 75390-9048, USA.
authors.forename: Regan M
authors.initials: RM
authors.lastname: Russell
authors.forename: Faith C
authors.initials: FC
authors.lastname: Sharp
authors.forename: David A
authors.initials: DA
authors.lastname: Rasko
authors.forename: Vanessa
authors.initials: V
authors.lastname: Sperandio
mesh_terms: D001483:Base Sequence; D019453:Escherichia coli O157 / Q000235:genetics* / Q000254:growth & development / Q000378:metabolism; D029968:Escherichia coli Proteins / Q000235:genetics* / Q000378:metabolism; D015964:Gene Expression Regulation, Bacterial; D005798:Genes, Bacterial; D006801:Humans; D007420:Intestine, Large / Q000166:cytology / Q000382:microbiology; D008957:Models, Genetic; D008969:Molecular Sequence Data; D010750:Phosphoproteins / Q000235:genetics* / Q000378:metabolism; D012689:Sequence Homology, Nucleic Acid; D015534:Trans-Activators / Q000235:genetics* / Q000378:metabolism; D014158:Transcription, Genetic
chemical_list: D029968:Escherichia coli Proteins; C457340:LEE protein, E coli; D010750:Phosphoproteins; C457339:QseA protein, E coli; D015534:Trans-Activators