Estimation of performance characteristics of a confirmation method for thyreostats in plasma by means of a weighted least-squares approach.
A weighted linear regression-based approach was applied to ascertain analytical performance characteristics of a method for the quantitative determination of thyreostats in plasma by LC-MS. The weights were set equal to the reciprocal of the variances. A straightforward and practical procedure is presented that was used to model the variance of the replicate measurements as a function of concentration. Different function types were tested for their suitability.
Steliopoulos
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P
Official Laboratory of Chemical and Veterinary Analysis Karlsruhe, 76187 Karlsruhe, Germany. Panagiotis.Steliopoulos@cvuaka.bwl.de
Stickel
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E
D002853:Chromatography, Liquid; D006801:Humans; D007093:Imidazoles / Q000097:blood*; D016018:Least-Squares Analysis; D013058:Mass Spectrometry; D015203:Reproducibility of Results
D007093:Imidazoles