Low-voltage electrohydrodynamic (EHD) spray drying of respirable particles.
Spray drying is a widely used process to produce pharmaceutical powders. In traditional spray drying, the particle size distribution is wide and not well controlled. Using EHD atomization for spray drying offers a possibility to tailor the particle size and morphology. In conventional EHD spray drying, the generated particles are charged and need to be discharged to avoid Rayleigh breakup. Discharging adds complexity to the process and eliminates the possibility to collect the powder using an electric field. The present work describes a novel EHD spray drying setup based on a low-voltage nozzle. The low-voltage nozzle imparts moderate charge to the droplets, which makes discharging unnecessary. The charged particles can be controlled and collected by using an auxiliary electric field. The EHD spray dryer has been characterized in terms of particle size, particle morphology, process output, and yield. The size distribution of the generated particles is very narrow. Both porous and completely spherical particles can be produced. The yield of small-scale bench-top equipment was 20%, which is similar to the yield of a small-scale conventional spray dryer. The effective output with five nozzles was 75 mg/hr of dry powder. Because of the repelling forces associated with the unipolarly charged droplets, the number of nozzles can be increased without risking coalescence.
Lastow
Orest
O
AstraZeneca R&D Lund, Lund, Sweden. Orest.Lastow@astrazeneca.com
Andersson
Jenny
J
Nilsson
Alexander
A
Balachandran
Wamadeva
W
D000280:Administration, Inhalation; D000336:Aerosols; D019819:Budesonide / Q000737:chemistry; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D004563:Electrochemistry / Q000295:instrumentation / Q000379:methods*; D005938:Glucocorticoids / Q000737:chemistry; D010316:Particle Size; D016062:Porosity; D011208:Powders / Q000737:chemistry; D013678:Technology, Pharmaceutical / Q000379:methods*
D000336:Aerosols; D005938:Glucocorticoids; D011208:Powders; D019819:Budesonide