[In vivo confocal microscopy in amiodarone corneal deposits].
OBJECTIVE
To describe in vivo confocal microscopy findings in patients with different stages of amiodarone-induced keratopathy, and correlate biomicroscopy stages with confocal stages.


METHODS
Twenty eyes of 10 patients (6 men and 4 women), who receive treatment with amiodarone were selected for the study with confocal microscopy (MC).


RESULTS
The average age was 58 +/- 6.2 years (50-66 years) and time of use of the drug was 6 +/- 3.2 years (2-11 years). All patients have best correct visual acuity > or =20/40. There were two patients in stage 1, 4 patients in stage 2 and 4 in stage 3 of induced keratopathy. All corneas presented brilliant intracellular inclusions with high reflectivity in the basal epithelium layer. Patients in stage 2 and 3 have all corneal layers affected. There are thinning and increase of tortuosity of corneal nerves in patients in stage 2 and 3. The endothelial count was 2,524 +/- 150,3 cell/mm(2).


CONCLUSIONS
The basal epithelium was most affected in any of the keratopathy stages. In stage 1 patients only the superficial and basal epithelium are affected, while patients in stages 2 and 3 have all corneal layers affected. With the advance of keratopathy the corneal nerves became thinner and tortuous.
Victor
Gustavo
G
Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil. gustavo.victor@eyeclinic.com.br
Alves
Milton Ruiz
MR
Nosé
Walton
W
D000368:Aged; D000638:Amiodarone / Q000009:adverse effects*; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects*; D003316:Corneal Diseases / Q000139:chemically induced* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D033401:Microscopy, Acoustic; D018613:Microscopy, Confocal; D008875:Middle Aged; D012720:Severity of Illness Index
D000889:Anti-Arrhythmia Agents; D000638:Amiodarone