title: Therapy-related, mixed-lineage leukaemia translocation-positive, monoblastic myeloid sarcoma of the uterus.
abstract: Myeloid sarcomas are tumour masses of myeloid leukaemic cells at extramedullary sites. These tumours can, on occasion, occur without concurrent or antecedent leukaemia. Myeloid sarcomas have been described at unusual locations including the female genital tract. An unusual case of therapy-related acute myeloid leukaemia (t-AML) presenting as isolated monoblastic myeloid sarcoma of the uterus in a patient who had received adjuvant chemotherapy for breast cancer is presented. Fluorescence in situ hybridisation analysis performed on paraffin-wax-embedded tumour tissue revealed a mixed-lineage leukaemia (MLL) gene rearrangement, supporting the association of this malignancy with prior chemotherapy. This case illustrates that t-AML can rarely present as isolated extramedullary tumours, and the detection of specific chromosomal abnormalities in these myeloid sarcomas can be useful for risk assessment and guiding definitive therapy.
authors.affiliation: Division of Haematology, City of Hope National Medical Center, Duarte, California 91010, USA. vpullarkat@coh.org
authors.forename: Vinod
authors.initials: V
authors.lastname: Pullarkat
authors.forename: Leslie
authors.initials: L
authors.lastname: Veliz
authors.forename: Karen
authors.initials: K
authors.lastname: Chang
authors.forename: Ann
authors.initials: A
authors.lastname: Mohrbacher
authors.forename: Anna Lizza
authors.initials: AL
authors.lastname: Teotico
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Forman
authors.forename: Marilyn L
authors.initials: ML
authors.lastname: Slovak
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D001943:Breast Neoplasms / Q000188:drug therapy; D017024:Chemotherapy, Adjuvant / Q000009:adverse effects; D005260:Female; D006801:Humans; D007951:Leukemia, Myeloid / Q000139:chemically induced* / Q000235:genetics / Q000473:pathology; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000139:chemically induced* / Q000235:genetics / Q000473:pathology; D014178:Translocation, Genetic; D014594:Uterine Neoplasms / Q000139:chemically induced* / Q000235:genetics / Q000473:pathology