Good news, bad news for missing-self recognition by NK cells: autoimmune control but viral evasion.
In this issue of Immunity, Voigt et al. (2007) and Lu et al. (2007) extend the understanding of the consequences of missing-self recognition in immune evasion and immune cell regulation via NKRP-1 and CD94-NKG2A inhibitory receptors, respectively.
Vivier
Eric
E
Centre d'Immunologie de Marseille-Luminy, Université de la Méditerranée, Marseille 13288, France. vivier@ciml.univ-mrs.fr
Romagné
François
F
D000818:Animals; D000954:Antigens, Surface / Q000276:immunology / Q000378:metabolism; D015551:Autoimmunity / Q000276:immunology*; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D037181:Lectins, C-Type / Q000276:immunology / Q000378:metabolism; D055651:NK Cell Lectin-Like Receptor Subfamily B; D055654:NK Cell Lectin-Like Receptor Subfamily C; D051920:NK Cell Lectin-Like Receptor Subfamily D / Q000276:immunology / Q000378:metabolism; D011971:Receptors, Immunologic / Q000276:immunology / Q000378:metabolism; D055607:Receptors, Natural Killer Cell; D053586:Virus Internalization
D000954:Antigens, Surface; C527203:KLRB1 protein, human; C527054:KLRC1 protein, human; D037181:Lectins, C-Type; D055651:NK Cell Lectin-Like Receptor Subfamily B; D055654:NK Cell Lectin-Like Receptor Subfamily C; D051920:NK Cell Lectin-Like Receptor Subfamily D; D011971:Receptors, Immunologic; D055607:Receptors, Natural Killer Cell