title: Oxidative stress and S100B protein in cirrhotic children.
abstract: Cirrhosis represents the terminal stage of a number of chronic liver diseases. Consequences include accumulation of toxic metabolic wastes, reduced synthesis of key proteins, increased portal venous pressure, and portosystemic shunting. We conducted a case-control study to assess the serum levels of S100B protein and parameters of oxidative stress, superoxide dismutase (SOD), catalase (CAT) and oxidative stress measured by the thiobarbituric acid method (TBARS), in a group of 14 pediatric patients with cirrhosis. No differences were found between groups in S100B protein levels. SOD activity and TBARS levels were higher; and CAT activity was lower in the cirrhotic group. A negative correlation between S100B and TBARS in the case group was found (r = -0.815, p = 0.001).
  
  
  CONCLUSIONS
  This study didn't indicate a possible role of S100B serum levels as marker of brain damage in cirrhotic children but suggest a possible relation between astrocyte function and oxidative damage in cirrhotic children.
authors.affiliation: Laboratório de Psiquiatria Experimental, Hospital de Clínicas de Porto Alegre e Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil. lribeiro@med.miami.edu
authors.forename: Luciana
authors.initials: L
authors.lastname: Ribeiro
authors.forename: Ana Cristina
authors.initials: AC
authors.lastname: Andreazza
authors.forename: Mirian
authors.initials: M
authors.lastname: Salvador
authors.forename: Themis Reverbel
authors.initials: TR
authors.lastname: da Silveira
authors.forename: Sandra
authors.initials: S
authors.lastname: Vieira
authors.forename: Daniel Bocchese
authors.initials: DB
authors.lastname: Nora
authors.forename: Cleonice
authors.initials: C
authors.lastname: Bosa
authors.forename: Francesca
authors.initials: F
authors.lastname: Di Napoli
authors.forename: Débora Vigevani
authors.initials: DV
authors.lastname: Schaf
authors.forename: Diogo Onofre
authors.initials: DO
authors.lastname: Souza
authors.forename: Luis Valmor Cruz
authors.initials: LV
authors.lastname: Portela
authors.forename: Flávio
authors.initials: F
authors.lastname: Kapczinski
mesh_terms: D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D002374:Catalase / Q000097:blood; D002648:Child; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood / Q000503:physiopathology*; D009414:Nerve Growth Factors / Q000097:blood*; D018384:Oxidative Stress / Q000502:physiology*; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000097:blood*; D013482:Superoxide Dismutase / Q000097:blood; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis
chemical_list: D015415:Biomarkers; D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; C579160:S100B protein, human; D017392:Thiobarbituric Acid Reactive Substances; D002374:Catalase; D013482:Superoxide Dismutase