title: New understanding of the group A Streptococcus pathogenesis cycle.
abstract: Group A Streptococcus (GAS) has long been recognized as a human pathogen causing an exceptionally broad range of infections. Despite intense research, however, the molecular mechanisms of GAS disease remain unclear. Recently, many important discoveries have been made that shed light on GAS pathogenesis and open exciting avenues for future research. Advances in genome sequencing, microarray technology and proteomic analysis, in combination with the development of more suitable animal models, have markedly increased our knowledge of the mechanisms underlying GAS pathogenesis. The information gained from these studies will translate into improved diagnostics and new targets for therapeutic drugs and vaccines.
authors.affiliation: Center for Molecular and Translational Human Infectious Diseases Research, The Methodist Hospital Research Institute, and Department of Pathology, The Methodist Hospital, 6565 Fannin Street B490, Houston, TX 77030, USA.
authors.forename: Anne H
authors.initials: AH
authors.lastname: Tart
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Walker
authors.forename: James M
authors.initials: JM
authors.lastname: Musser
mesh_terms: D002353:Carrier State / Q000382:microbiology; D005838:Genotype; D006801:Humans; D012703:Serotyping; D013290:Streptococcal Infections / Q000503:physiopathology*; D013297:Streptococcus pyogenes / Q000235:genetics / Q000378:metabolism / Q000472:pathogenicity*; D037521:Virulence Factors
chemical_list: D037521:Virulence Factors