NRG1 and synaptic function in the CNS.
Recent genetic evidence indicates that neuregulin 1 (NRG1) and its receptor erbB4 may be susceptibility genes in schizophrenia, but their function in CNS synaptic transmission and circuitry is not well understood. In this issue of Neuron, studies from Li et al. and Woo et al. show that NRG1 and erbB4 regulate transmission at brain glutamate and GABA synapses. These findings raise the possibility of synaptic defects in schizophrenia.
Fischbach
Gerald D
GD
Columbia University, New York, NY 10027, USA. gf224@columbia.edu
D000818:Animals; D002490:Central Nervous System / Q000166:cytology*; D018698:Glutamic Acid / Q000378:metabolism; D020890:Neuregulin-1 / Q000502:physiology*; D013569:Synapses / Q000502:physiology*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D020890:Neuregulin-1; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid