Association between antenatal depression and low birthweight in a developing country.
OBJECTIVE
There is a high prevalence of depression in south Asian women. We aimed to examine the association between antenatal depression and low birthweight (LBW) in infants in a rural community in Rawalpindi, Pakistan.


METHODS
A total of 143 physically healthy mothers with ICD-10 depression in the third trimester of pregnancy and 147 non-depressed mothers of similar gestation were followed from birth. Infant weight was measured and information collected on socioeconomic status, maternal body-mass index and sociodemographic factors.


RESULTS
Infants of depressed mothers had lower birthweight (mean 2910 g) than infants of non-depressed mothers (mean 3022 g). The relative risk for LBW (< or =2500 g) in infants of depressed mothers was 1.9 (95% CI 1.3-2.9). The association remained significant after adjustment for confounders by multivariate analyses.


CONCLUSIONS
Low birthweight is a major public health problem in developing countries. Maternal depression during pregnancy predicts LBW. Interventions aimed at maternal depression may help improve infant outcomes.
Rahman
A
A
Department of Psychological Medicine, University of Manchester, Manchester, UK.
Bunn
J
J
Lovel
H
H
Creed
F
F
D000328:Adult; D003865:Major Depressive Disorder / Q000175:diagnosis* / Q000523:psychology*; D003906:Developing Countries; D005260:Female; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D010500:Perinatology; D011247:Pregnancy; D011248:Pregnancy Complications