title: Role of aralar, the mitochondrial transporter of aspartate-glutamate, in brain N-acetylaspartate formation and Ca(2+) signaling in neuronal mitochondria.
abstract: Aralar, the Ca(2+)-dependent mitochondrial aspartate-glutamate carrier expressed in brain and skeletal muscle, is a member of the malate-aspartate NADH shuttle. Disrupting the gene for aralar, SLC25a12, in mice has enabled the discovery of two new roles of this carrier. On the one hand, it is required for synthesis of brain aspartate and N-acetylaspartate, a neuron-born metabolite that supplies acetate for myelin lipid synthesis; and on the other, it is essential for the transmission of small Ca(2+) signals to mitochondria via an increase in mitochondrial NADH.
authors.affiliation: Departamento de Biología Molecular, Centro de Biología Molecular Severo Ochoa, Facultad de Ciencias, Universidad Autónoma, 28049, Cantoblanco, Madrid, Spain jsatrustegui@cbm.uam.es
authors.forename: Jorgina
authors.initials: J
authors.lastname: Satrústegui
authors.forename: Laura
authors.initials: L
authors.lastname: Contreras
authors.forename: Milagros
authors.initials: M
authors.lastname: Ramos
authors.forename: Patricia
authors.initials: P
authors.lastname: Marmol
authors.forename: Araceli
authors.initials: A
authors.lastname: del Arco
authors.forename: Takeyori
authors.initials: T
authors.lastname: Saheki
authors.forename: Beatriz
authors.initials: B
authors.lastname: Pardo
mesh_terms: D000818:Animals; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000096:biosynthesis; D001921:Brain / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism*; D006801:Humans; D026901:Membrane Transport Proteins / Q000378:metabolism*; D051379:Mice; D008928:Mitochondria / Q000378:metabolism*; D033681:Mitochondrial Membrane Transport Proteins; D024101:Mitochondrial Proteins / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism*
chemical_list: D026901:Membrane Transport Proteins; D033681:Mitochondrial Membrane Transport Proteins; D024101:Mitochondrial Proteins; C491956:Slc25a12 protein, mouse; D001224:Aspartic Acid; C000179:N-acetylaspartate; D002118:Calcium