title: Phytochemical and antiprotozoal activity of Ocotea lancifolia.
abstract: Thirteen known isoquinoline alkaloids were isolated from Ocotea lancifolia, popularly known as << canela pilosa >> in Brasil and << laurel né >> by the Guarani people which means smell laurel. Their activities against the promastigote forms of three Leishmania strains and the bloodstream form of Trypanosoma cruzi were evaluated, as well as their hepatocytotoxicity. Among them, the noraporphine alkaloid (-) caaverine has shown the most interesting antiprotozoal activity against Leishmania and T. cruzi parasites.
authors.affiliation: IRD, US 084, Laboratoire de Pharmacognosie, Faculté de Pharmacie, Université Paris-Sud, rue J.B. Clément, 92296 Châtenay-Malabry, France. alain.fournet@ird.fr
authors.forename: Alain
authors.initials: A
authors.lastname: Fournet
authors.forename: Maria Elena
authors.initials: ME
authors.lastname: Ferreira
authors.forename: Antonieta
authors.initials: A
authors.lastname: Rojas de Arias
authors.forename: Isabelle
authors.initials: I
authors.lastname: Guy
authors.forename: Hélène
authors.initials: H
authors.lastname: Guinaudeau
authors.forename: Horacio
authors.initials: H
authors.lastname: Heinzen
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D007891:Leishmania / Q000145:classification / Q000187:drug effects*; D027444:Ocotea; D021261:Parasitic Sensitivity Tests; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D014344:Trypanocidal Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D014349:Trypanosoma cruzi / Q000187:drug effects*
chemical_list: D000981:Antiprotozoal Agents; D010936:Plant Extracts; D014344:Trypanocidal Agents