Upd/Jak/STAT signaling represses wg transcription to allow initiation of morphogenetic furrow in Drosophila eye development.
The initiation of retinal development in Drosophila begins at the posterior center (PC) of the eye disc margin. The front of the differentiation wave, recognized as a morphogenetic furrow (MF), moves from posterior to anterior. What determines MF initiates from the specific PC site is still unclear. The unpaired (upd) gene is expressed at PC at early third instar, just before the time of MF initiation. Therefore, upd is expressed at the appropriate time and location for a specific role in defining the site of MF initiation. upd encodes a ligand for the Jak/STAT signaling pathway. In this report, we showed that the Upd/Jak/STAT signaling is required and sufficient to determine MF initiation. This is primarily achieved by repressing the transcription of wingless (wg), which is known to block MF initiation.
Tsai
Yu-Chen
YC
Institute of Molecular Biology, Academia Sinica, Nankang, Taipei, Taiwan, Republic of China.
Yao
Jih-Guang
JG
Chen
Po-Hao
PH
Posakony
James W
JW
Barolo
Scott
S
Kim
Jaesob
J
Sun
Y Henry
YH
D000818:Animals; D030801:Animals, Genetically Modified; D002454:Cell Differentiation; D029721:Drosophila Proteins / Q000235:genetics* / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000196:embryology; D018507:Gene Expression Regulation, Developmental; D007150:Immunohistochemistry; D053613:Janus Kinase 1 / Q000378:metabolism*; D008024:Ligands; D017956:Photoreceptor Cells, Invertebrate / Q000196:embryology* / Q000378:metabolism; D011518:Proto-Oncogene Proteins / Q000235:genetics* / Q000378:metabolism; D050791:STAT Transcription Factors / Q000378:metabolism; D015398:Signal Transduction; D014157:Transcription Factors / Q000378:metabolism*; D014158:Transcription, Genetic; D051155:Wnt1 Protein
D029721:Drosophila Proteins; D008024:Ligands; D011518:Proto-Oncogene Proteins; D050791:STAT Transcription Factors; D014157:Transcription Factors; D051155:Wnt1 Protein; C115570:upd1 protein, Drosophila; C074622:wg protein, Drosophila; D053613:Janus Kinase 1