Genome-wide high-frequency non-Mendelian loss of heterozygosity in rice.
Classic Mendelian genetics declares that hybrids inherit genomic information from both male and female parents, and that alleles should be heterozygous in F1 plants. A few exceptions to this principle have been reported, but most of them are restricted to either a limited set of specific genes or specific types of alleles. Here, we show that a rice triploid and diploid hybridization resulted in stable diploid progenies, both in genotypes and phenotypes, through gene homozygosity. Furthermore, their gene homozygosity can be inherited through 8 generations, and they can convert DNA sequences of other rice varieties into their own. Molecular-marker examination confirmed that this type of genome-wide gene conversion occurred at a very high frequency. Possible mechanisms, including RNA-templated repair of double-strand DNA, are discussed.
Xu
Pei-Zhou
PZ
Rice Research Institute, Sichuan Agricultural University, Wenjiang, Sichuan 611130, P.R. China.
Yuan
Shu
S
Li
Yun
Y
Zhang
Hong-Yu
HY
Wang
Xu-Dong
XD
Lin
Hong-Hui
HH
Wu
Xian-Jun
XJ
D004260:DNA Repair / Q000235:genetics; D018744:DNA, Plant / Q000235:genetics / Q000378:metabolism; D004171:Diploidy; D018745:Genome, Plant; D005838:Genotype; D006720:Homozygote; D006824:Hybridization, Genetic; D019656:Loss of Heterozygosity; D008957:Models, Genetic; D012275:Oryza / Q000235:genetics* / Q000378:metabolism; D010641:Phenotype; D011123:Polyploidy
D018744:DNA, Plant