title: Evolution of the carboxylate Jen transporters in fungi.
abstract: Synteny analysis is combined with sequence similarity and motif identification to trace the evolution of the putative monocarboxylate (lactate/pyruvate) transporters Jen1p and the dicarboxylate (succinate/fumarate/malate) transporters Jen2p in Hemiascomycetes yeasts and Euascomycetes fungi. It is concluded that a precursor form of Jen1p, named here preJen1p, arose by the duplication of an ancestral Jen2p, during the speciation of Yarrowia lipolytica, which was transferred into a new syntenic context. The Jen1p transporters differentiated from preJen1p in Kluyveromyces lactis, before the Whole Genome Duplication (WGD), and are conserved as a single copy in the Saccharomyces species. In contrast, the ancestral Jen2p was definitively lost just prior to the WGD and is absent in Saccharomyces.
authors.affiliation: Dipartimento di Genetica Biologia dei Microrganismi Antropologia Evoluzione, Università di Parma, Parma, Italy. tiziana.lodi@unipr.it
authors.forename: Tiziana
authors.initials: T
authors.lastname: Lodi
authors.forename: Julie
authors.initials: J
authors.lastname: Diffels
authors.forename: André
authors.initials: A
authors.lastname: Goffeau
authors.forename: Philippe V
authors.initials: PV
authors.lastname: Baret
mesh_terms: D000595:Amino Acid Sequence; D001203:Ascomycota / Q000145:classification / Q000235:genetics* / Q000378:metabolism; D019143:Evolution, Molecular; D005656:Fungal Proteins / Q000737:chemistry / Q000235:genetics; D008969:Molecular Sequence Data; D027501:Monocarboxylic Acid Transporters / Q000737:chemistry / Q000235:genetics*; D010802:Phylogeny; D027981:Symporters / Q000737:chemistry / Q000235:genetics*; D026801:Synteny
chemical_list: D005656:Fungal Proteins; D027501:Monocarboxylic Acid Transporters; D027981:Symporters