title: Novel linear polymers bearing thiosialosides as pendant-type epitopes for influenza neuraminidase inhibitors.
abstract: A conventional synthesis of alpha-thioglycoside of sialic acid as a glycomonomer was accomplished. Radical copolymerization of the glycomonomer with vinyl acetate proceeded smoothly to afford a new class of glycopolymers having thiosialoside residues, in which all protection was removed by a combination of transesterification and saponification to provide a water-soluble thiosialoside cluster. The results of a preliminary study on biological responses against influenza virus neuraminidases using the thiosialoside polymer as a candidate for a neuraminidase inhibitor showed that the glycopolymer has potent inhibitory activity against the neuraminidases.
authors.affiliation: Area for Molecular Function, Division of Material Science, Graduate School of Science and Engineering, Saitama University, Sakura, Saitama 338-8570, Japan. koji@fms.saitama-u.ac.jp
authors.forename: Koji
authors.initials: K
authors.lastname: Matsuoka
authors.forename: Chiharu
authors.initials: C
authors.lastname: Takita
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Koyama
authors.forename: Daisei
authors.initials: D
authors.lastname: Miyamoto
authors.forename: Sangchai
authors.initials: S
authors.lastname: Yingsakmongkon
authors.forename: Kazuya I P J
authors.initials: KI
authors.lastname: Hidari
authors.forename: Wipawee
authors.initials: W
authors.lastname: Jampangern
authors.forename: Takashi
authors.initials: T
authors.lastname: Suzuki
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Ken
authors.initials: K
authors.lastname: Hatano
authors.forename: Daiyo
authors.initials: D
authors.lastname: Terunuma
mesh_terms: D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D000939:Epitopes / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D019158:N-Acetylneuraminic Acid / Q000737:chemistry / Q000494:pharmacology*; D009439:Neuraminidase / Q000037:antagonists & inhibitors*; D009975:Orthomyxoviridae / Q000201:enzymology*; D011108:Polymers / Q000737:chemistry / Q000494:pharmacology*; D013055:Spectrophotometry, Infrared
chemical_list: D004791:Enzyme Inhibitors; D000939:Epitopes; D011108:Polymers; D009439:Neuraminidase; D019158:N-Acetylneuraminic Acid