Chronic 3,4-methylenedioxymethamphetamine treatment suppresses cell proliferation in the adult mouse dentate gyrus.
We investigated the influence of chronic 3,4-methylenedioxymethamphetamine (MDMA) treatment on cell proliferation in the adult dentate gyrus. Mice were orally treated with MDMA (1.25 mg/kg-40 mg/kg) or saline for 30 days. To label dividing cells, mice were given 5-bromo-2'-deoxyuridine (BrdU) for 4 days from the day after the last administration of MDMA, and their brains were examined 24 h later. MDMA dose-dependently induced a decrease in the number of BrdU-positive cells in the male and female dentate gyrus. Our results suggest that chronic exposure to MDMA suppresses cell proliferation in the dentate gyrus.
Cho
Kyung-Ok
KO
Department of Pharmacology, College of Medicine, The Catholic University of Korea, 137-701, Seoul, South Korea.
Kim
Seul-Ki
SK
Rhee
Gyu Seek
GS
Kwack
Seung Jun
SJ
Cho
Dae Hyun
DH
Sung
Ki-Wug
KW
Kim
Seong Yun
SY
D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D018891:Dentate Gyrus / Q000166:cytology / Q000187:drug effects*; D005260:Female; D006213:Hallucinogens / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018817:N-Methyl-3,4-methylenedioxyamphetamine / Q000494:pharmacology*; D018490:Serotonin Agents / Q000494:pharmacology
D006213:Hallucinogens; D018490:Serotonin Agents; D018817:N-Methyl-3,4-methylenedioxyamphetamine