title: The organophosphate-induced acute-phase response is characterized by synthesis of alpha 1-acid glycoprotein that exhibits an immunomodulatory effect.
abstract: The organophosphorus compounds soman and paraoxon induce the acute-phase (AP) response. All phases of the AP response, from macrophage activation and stimulation of glucocorticoid secretion to AP protein expression appear to be under the control of similar molecular mechanisms to those during the turpentine-induced AP response. The AP protein content in the circulation 24 h after either soman, paraoxon or turpentine administration was injury-specific. Both soman and paraoxon poisoning were characterized by significantly increased synthesis of alpha(1)-acid glycoprotein (AGP) that displayed an immunomodulatory effect in vitro. This result suggests that after organophosphate poisoning AGP participates in vivo in a negative feedback mechanism that prevents over-activity of the immune system.
authors.affiliation: Department of Molecular Biology, Institute for Biological Research, Bulevar despota Stefana 142, 11060 Belgrade, Serbia. smatic@ibiss.bg.ac.yu
authors.forename: Svetlana
authors.initials: S
authors.lastname: Ivanović-Matić
authors.forename: Goran
authors.initials: G
authors.lastname: Poznanović
authors.forename: Ilijana
authors.initials: I
authors.lastname: Grigorov
authors.forename: Svetlana
authors.initials: S
authors.lastname: Dinić
authors.forename: Mirjana
authors.initials: M
authors.lastname: Mihailović
authors.forename: Nevena
authors.initials: N
authors.lastname: Grdović
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Uskoković
authors.forename: Vesna
authors.initials: V
authors.lastname: Martinović
authors.forename: Jelena
authors.initials: J
authors.lastname: Arambasić
authors.forename: Miodrag
authors.initials: M
authors.lastname: Petrović
authors.forename: Desanka
authors.initials: D
authors.lastname: Bogojević
mesh_terms: D000209:Acute-Phase Proteins / Q000235:genetics / Q000276:immunology; D000818:Animals; D002478:Cells, Cultured; D003345:Corticosterone / Q000097:blood; D007155:Immunologic Factors / Q000235:genetics / Q000276:immunology* / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects / Q000276:immunology; D008297:Male; D009961:Orosomucoid / Q000235:genetics / Q000276:immunology* / Q000494:pharmacology; D010261:Paraoxon / Q000633:toxicity*; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012999:Soman / Q000633:toxicity*; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D014425:Turpentine / Q000633:toxicity
chemical_list: D000209:Acute-Phase Proteins; D007155:Immunologic Factors; D009961:Orosomucoid; D012333:RNA, Messenger; D012999:Soman; D010261:Paraoxon; D003345:Corticosterone; D014425:Turpentine