title: Near-fatal betaxolol self-poisoning treated with percutaneous extracorporeal life support.
abstract: We present a case of successful treatment of near-fatal beta-blocker self-poisoning but requiring extracorporeal circulatory support with severe complications. A 38-year-old woman ingested a mixture of tablets including betaxolol (5.32 g). Despite intensive treatment with fluid, dobutamine, isoprenaline, epinephrine, nor-epinephrine and glucagon, sustained cardiogenic shock occurred with almost complete hypokinesia of the left ventricular 14 h later. Therefore, a cardiac support was performed with a percutaneous cardiopulmonary bypass device at bedside. We review the literature with emphasis on both the best time to start this technique and its complications.
authors.forename: Pascal
authors.initials: P
authors.lastname: Bilbault
authors.forename: Sophie
authors.initials: S
authors.lastname: Pynn
authors.forename: Cyrille
authors.initials: C
authors.lastname: Mathien
authors.forename: Jean P
authors.initials: JP
authors.lastname: Mazzucotelli
authors.forename: Francis
authors.initials: F
authors.lastname: Schneider
authors.forename: A
authors.initials: A
authors.lastname: Jaeger
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology / Q000628:therapy; D000328:Adult; D015784:Betaxolol / Q000506:poisoning*; D015199:Extracorporeal Membrane Oxygenation; D005260:Female; D017583:Hemodiafiltration; D006801:Humans; D011041:Poisoning / Q000628:therapy; D012770:Shock, Cardiogenic / Q000209:etiology / Q000628:therapy
chemical_list: D015784:Betaxolol