Basic autonomic nervous function in patients with neurocardiogenic syncope.
Basic autonomic nervous function was evaluated in patients with neurocardiogenic syncope (NCS). Atropine, isoproterenol, propranolol, phenylephrine, and phentolamine were administered successively, and parasympathetic nerve activity and beta- (and alpha-) activity, sensitivity, and secretion of the sympathetic nerve were determined in patients with NCS and control subjects. In patients with NCS, beta- and alpha- sensitivity were higher and beta-activity and beta- and alpha-secretion lower than in control subjects. In patients with NCS, the increased basic beta-sensitivity may contribute to induce strong cardiac contractions and augment ventricular mechanoreceptor response, and a compensatory state against diminished neuronal sympathetic activity is suggested by the increased alpha-sensitivity.
Saito
Fumio
F
Department of Cardiology, Surugadai Nihon University Hospital, Tokyo, Japan. fsaito@med.nihon-u.ac.jp
Imai
Shinobu
S
Tanaka
Nobuyuki
N
Tanaka
Hideyuki
H
Suzuki
Kazutaka
K
Takase
Hidehito
H
Aoyama
Hiroshi
H
Matsudaira
Kagari
K
Ebuchi
Tomonori
T
Akamine
Yasuyuki
Y
Takahashi
Naoyuki
N
Sugino
Keiichi
K
Kanmatsuse
Katsuo
K
Yagi
Hiroshi
H
Kushiro
Toshio
T
D000293:Adolescent; D000316:Adrenergic alpha-Agonists / Q000008:administration & dosage; D000317:Adrenergic alpha-Antagonists / Q000008:administration & dosage; D000318:Adrenergic beta-Agonists / Q000008:administration & dosage; D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage; D000328:Adult; D001285:Atropine / Q000008:administration & dosage; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D005260:Female; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D006801:Humans; D007262:Infusions, Intravenous; D007545:Isoproterenol / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D010275:Parasympathetic Nervous System / Q000187:drug effects / Q000503:physiopathology*; D010276:Parasympatholytics / Q000008:administration & dosage; D010646:Phentolamine / Q000008:administration & dosage; D010656:Phenylephrine / Q000008:administration & dosage; D011433:Propranolol / Q000008:administration & dosage; D012720:Severity of Illness Index; D013564:Sympathetic Nervous System / Q000187:drug effects / Q000503:physiopathology*; D019462:Syncope, Vasovagal / Q000097:blood / Q000175:diagnosis / Q000503:physiopathology*
D000316:Adrenergic alpha-Agonists; D000317:Adrenergic alpha-Antagonists; D000318:Adrenergic beta-Agonists; D000319:Adrenergic beta-Antagonists; D010276:Parasympatholytics; D010656:Phenylephrine; D001285:Atropine; D011433:Propranolol; D007545:Isoproterenol; D010646:Phentolamine