[Chronic asymptomatic hyperuricemia as a marker of atherogenic risk in children].
A cross-sectional study of a representative sample of boys aged 7-17 years (n=569) was carried out in Arkhangelsk. The rate of asymptomatic hyperuricemia was 27.59 %. Serum level of uric acid correlated with levels of triglycerides, total cholesterol, low density lipoprotein cholesterol, fasting glycemia, systolic and diastolic blood pressure (r = 0.49; 0.27; 0.27; 0.26; 0.34 u 0.35, respectively; p<0,05). Prevalence of borderline and pronounced hyperlipidemia, elevated blood pressure, and impaired fasting glycemia among children with elevated uric acid level was higher than among children with normal level of uric acid. Chronic asymptomatic hyperuricemia in childhood can be regarded as marker of atherogenic risk because of its association with atherogenic phenotype of lipids and lipoproteins levels, increased fasting glycemia and elevated blood pressure.
Maliavskaia
S I
SI
Lebedev
A V
AV
Ternovskaia
V A
VA
D000293:Adolescent; D000367:Age Factors; D050197:Atherosclerosis / Q000453:epidemiology / Q000209:etiology*; D015415:Biomarkers; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure; D016009:Chi-Square Distribution; D002648:Child; D002908:Chronic Disease; D006801:Humans; D006949:Hyperlipidemias / Q000150:complications / Q000175:diagnosis; D033461:Hyperuricemia / Q000150:complications / Q000453:epidemiology*; D008297:Male; D012307:Risk Factors; D012426:Russia / Q000453:epidemiology; D012737:Sex Factors; D014527:Uric Acid / Q000097:blood
D015415:Biomarkers; D001786:Blood Glucose; D014527:Uric Acid