Preventing blindness in retinal disease: ciliary neurotrophic factor intraocular implants.
A recent phase I trial of an encapsulated cell therapy device that delivers ciliary neurotrophic factor has shown the potential of this approach in the treatment of retinitis pigmentosa. As experience with this device is gained, other retinal degenerative disorders may be potential targets of a similar therapeutic approach.
MacDonald
Ian M
IM
National Eye Institute, National Institute of Health, Bethesda, MD 20892-1860, USA. macdonaldi@mail.nih.gov
Sauvé
Yves
Y
Sieving
Paul A
PA
D001766:Blindness / Q000517:prevention & control*; D020934:Ciliary Neurotrophic Factor / Q000627:therapeutic use*; D017321:Clinical Trials, Phase I as Topic; D004343:Drug Implants; D006801:Humans; D012162:Retinal Degeneration / Q000188:drug therapy*
D020934:Ciliary Neurotrophic Factor; D004343:Drug Implants