title: A new strategy to replace the natural vitreous by a novel capsular artificial vitreous body with pressure-control valve.
abstract: OBJECTIVE
  The current vitreous substitutes such as silicone oil, heavy silicone oil, and polymeric gels that are directly injected into vitreous cavity frequently cause severe intraocular complications. There is a very urgent need to find a more suitable artificial vitreous substitute for pars plana vitrectomy (PPV) surgery.
  
  
  METHODS
  We have devised a novel capsular artificial vitreous using tailor-made silicone rubber elastomer. The novel device was implanted into the vitreous cavity of rabbit after PPV and the eye was examined by ophthalmoscopy, fundus photography, and tonometry during an 8-week treatment period. B-scan ultrasonography, electroretinogram (ERG), and histological studies by light microscopy were also performed at the end of 8 weeks.
  
  
  RESULTS
  The novel artificial vitreous body consists of a thin vitreous-like capsule with a silicone tube-valve system. The capsule can be folded and implanted into vitreous cavity through 1.5 mm incision on sclera. Physiological balanced solution (PBS) was then injected into the capsule and inflated to support retina and control intraocular pressure (IOP) through the tube-valve system subsequently fixed under the conjunctiva. Experiments using rabbits showed that the novel vitreous body could effectively support the retina and apparently induced no significant pathological changes in the eye over 8 weeks.
  
  
  CONCLUSIONS
  This approach may provide a new research strategy in the vitreous replacement technology. The novel artificial vitreous body device can effectively support retina, control IOP, and has good biocompatibility. It may be a good alternative to injecting artificial vitreous although its tamponade properties and usefulness still have to be proven in complex vitreoretinal diseases.
authors.affiliation: Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China. gaiogy@hotmail.com
authors.forename: Q
authors.initials: Q
authors.lastname: Gao
authors.forename: S
authors.initials: S
authors.lastname: Mou
authors.forename: J
authors.initials: J
authors.lastname: Ge
authors.forename: C-H
authors.initials: CH
authors.lastname: To
authors.forename: Y
authors.initials: Y
authors.lastname: Hui
authors.forename: A
authors.initials: A
authors.lastname: Liu
authors.forename: Z
authors.initials: Z
authors.lastname: Wang
authors.forename: C
authors.initials: C
authors.lastname: Long
authors.forename: J
authors.initials: J
authors.lastname: Tan
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000627:therapeutic use*; D004596:Electroretinography; D007429:Intraocular Pressure / Q000502:physiology; D008422:Materials Testing / Q000379:methods; D008854:Microscopy, Electron; D011474:Prosthesis Design; D011817:Rabbits; D012826:Silicone Elastomers / Q000627:therapeutic use*; D014821:Vitrectomy / Q000534:rehabilitation; D014822:Vitreous Body / Q000648:ultrastructure
chemical_list: D001672:Biocompatible Materials; D012826:Silicone Elastomers