title: [Clinical and laboratory aspects of the phenomenon of macroprolactinemia].
abstract: The question of the clinical importance of high-molecular prolactin forms is stressed in modern scientific literature on the problem of hyperprolactinemia. About 25% of all cases of hyperprolactinemia have been associated with the phenomenon of macroprolactinemia. This is most typical of patients with mild or moderate increase in prolactin level. There is no consensus on the therapeutic tactics in these patients. It should be discussed whether macroprolactin measurements should be done in all cases of high total prolactin level in order to prevent hyperdiagnostics and unnecessary additional laboratory tests and therapeutic intervention.
authors.forename: G A
authors.initials: GA
authors.lastname: Mel'nichenko
authors.forename: N P
authors.initials: NP
authors.lastname: Goncharov
authors.forename: L K
authors.initials: LK
authors.lastname: Dzeranova
authors.forename: I I
authors.initials: II
authors.lastname: Barmina
mesh_terms: D001323:Autoantibodies / Q000032:analysis; D015153:Blotting, Western; D002850:Chromatography, Gel; D006801:Humans; D006966:Hyperprolactinemia / Q000097:blood / Q000145:classification / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy; D011092:Polyethylene Glycols; D011233:Precipitin Tests; D011388:Prolactin / Q000097:blood* / Q000276:immunology; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D013967:Thyroiditis, Autoimmune / Q000276:immunology
chemical_list: D001323:Autoantibodies; C060678:prolactin, polymeric; D011092:Polyethylene Glycols; D011388:Prolactin