Anti-inflammation role for mesenchymal stem cells transplantation in myocardial infarction.
The aim of the present study was to investigate the role of anti-inflammation for MSCs transplantation in rat models of myocardial infarction. Rats with AMI induced by occlusion of the left coronary artery were randomized to MSCs transplantation group, MI group and sham operated group. The effects of MSCs transplantation on cardiac inflammation and left ventricular remodeling in non-infarcted zone were observed after 4 weeks of MI. We found that MSC transplantation (1) decreased protein production and gene expression of inflammation cytokines TNF-alpha, IL-1beta and IL-6, (2) inhibited deposition of type I and III collagen, as well as gene and protein expression of MMP-1 and TIMP-1, (3) attenuated LV cavitary dilation and transmural infarct thinning, thus prevent myocardial remodeling after myocardial infarction, and (4) increased EF, FS, LVESP and dp/dtmax (P < 0.01), decreased LVDd, LVEDV, LVEDP (P < 0.05). Anti-inflammation role for MSCs transplantation might partly account for the cardiac protective effect in ischemic heart disease.
Guo
Jun
J
Department of Cardiology, Renmin Hospital of Wuhan University school of medicine, 238 JieFang Road, Wuchang, Wuhan, 430060, People's Republic of China. dr_guoj2008@yahoo.com
Lin
Guo-sheng
GS
Bao
Cui-yu
CY
Hu
Zhi-min
ZM
Hu
Ming-yan
MY
D000818:Animals; D024042:Collagen Type I / Q000378:metabolism; D024061:Collagen Type III / Q000378:metabolism; D004452:Echocardiography; D015870:Gene Expression / Q000276:immunology; D017379:Hypertrophy, Left Ventricular / Q000000981:diagnostic imaging / Q000276:immunology / Q000628:therapy; D053583:Interleukin-1beta / Q000235:genetics; D015850:Interleukin-6 / Q000235:genetics; D008297:Male; D020781:Matrix Metalloproteinase 1 / Q000235:genetics / Q000378:metabolism; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000276:immunology*; D009203:Myocardial Infarction / Q000000981:diagnostic imaging / Q000276:immunology* / Q000628:therapy*; D009205:Myocarditis / Q000000981:diagnostic imaging / Q000276:immunology / Q000628:therapy; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D019715:Tissue Inhibitor of Metalloproteinase-1 / Q000235:genetics / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics
D024042:Collagen Type I; D024061:Collagen Type III; D053583:Interleukin-1beta; D015850:Interleukin-6; D019715:Tissue Inhibitor of Metalloproteinase-1; D014409:Tumor Necrosis Factor-alpha; D020781:Matrix Metalloproteinase 1