title: Merkel cell-poor trichoblastoma with basal cell carcinoma-like foci.
abstract: We reexamined 11 cases of trichoblastoma, and two cases of trichoblastoma with basal cell carcinoma (BCC)-like foci were found. In these two trichoblastomas with BCC-like foci, the BCC-like foci were often localized in peripheral or deep areas of lesions extending out of the fibrocytic stroma. Immunohistochemistry was performed in five conventional trichoblastomas and in two trichoblastomas with BCC-like foci, using antibodies against CK20 and CK15. No CK20-positive Merkel cells and no expression of CK15 were seen in any neoplastic aggregations of the two trichoblastomas with BCC-like foci. In contrast, increased numbers of Merkel cells and positive staining for CK15 were observed in all five trichoblastomas without BCC-like foci. The five trichoblastomas without BCC-like foci included two trichoblastomas with a popped out or shelled out appearance, which characteristically had a thick fibrous capsule surrounding the fibrotic stroma, demonstrating numerous Merkel cells in the aggregations. Some trichoblastomas may undergo mutations, resulting in the development of foci of BCC and in the loss of the expression of CK15 as well as the disappearance of Merkel cells.
authors.affiliation: Division of Dermatology, Department of Internal Medicine, Saga University, Saga, Japan. misago@post.saga-med.ac.jp
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Misago
authors.forename: Toshimi
authors.initials: T
authors.lastname: Satoh
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Miura
authors.forename: Kohtarou
authors.initials: K
authors.lastname: Nagase
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Narisawa
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D002280:Basal Cell Carcinoma / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D005260:Female; D006201:Hair Diseases / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D018859:Hair Follicle / Q000737:chemistry / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D053569:Keratin-15 / Q000032:analysis; D008297:Male; D018862:Merkel Cells / Q000737:chemistry / Q000473:pathology*; D008875:Middle Aged; D012189:Retrospective Studies; D012878:Skin Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery
chemical_list: D014408:Biomarkers, Tumor; D053569:Keratin-15