Recent advances in asymmetric phase-transfer catalysis.
The use of chiral nonracemic onium salts and crown ethers as effective phase-transfer catalysts have been studied intensively primarily for enantioselective carbon-carbon or carbon-heteroatom bond-forming reactions under mild biphasic conditions. An essential issue for optimal asymmetric catalysis is the rational design of catalysts for targeted reaction, which allows generation of a well-defined chiral ion pair that reacts with electrophiles in a highly efficient and stereoselective manner. This concept, together with the synthetic versatility of phase-transfer catalysis, provides a reliable and general strategy for the practical asymmetric synthesis of highly valuable organic compounds.
Ooi
Takashi
T
Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606-8502, Japan.
Maruoka
Keiji
K
D002384:Catalysis; D043844:Crown Ethers / Q000737:chemistry*; D015394:Molecular Structure; D009861:Onium Compounds / Q000737:chemistry*; D009930:Organic Chemicals / Q000138:chemical synthesis / Q000737:chemistry; D044367:Phase Transition; D013237:Stereoisomerism
D043844:Crown Ethers; D009861:Onium Compounds; D009930:Organic Chemicals