title: "O-acyl isopeptide method" for peptide synthesis: synthesis of forty kinds of "O-acyl isodipeptide unit" Boc-Ser/Thr(Fmoc-Xaa)-OH.
abstract: The O-acyl isopeptide method has recently received attention as an efficient synthetic method for peptides. Herein, forty kinds of "O-acyl isodipeptide unit" Boc-Ser/Thr(Fmoc-Xaa)-OH (1-40) were effectively synthesized in two-steps without epimerization. The O-acyl isodipeptide units are important building blocks to enable the routine use of the O-acyl isopeptide method.
authors.affiliation: Department of Medicinal Chemistry, Center for frontier Research in Medicinal Science, 21st Century COE program, Kyoto Pharmaceutical University, Yamashina-ku, Kyoto 607-8412, Japan.
authors.forename: Taku
authors.initials: T
authors.lastname: Yoshiya
authors.forename: Atsuhiko
authors.initials: A
authors.lastname: Taniguchi
authors.forename: Youhei
authors.initials: Y
authors.lastname: Sohma
authors.forename: Fukue
authors.initials: F
authors.lastname: Fukao
authors.forename: Setsuko
authors.initials: S
authors.lastname: Nakamura
authors.forename: Naoko
authors.initials: N
authors.lastname: Abe
authors.forename: Nui
authors.initials: N
authors.lastname: Ito
authors.forename: Mariusz
authors.initials: M
authors.lastname: Skwarczynski
authors.forename: Tooru
authors.initials: T
authors.lastname: Kimura
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Hayashi
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Kiso
mesh_terms: D000595:Amino Acid Sequence; D002625:Chemistry, Organic / Q000379:methods*; D002851:Chromatography, High Pressure Liquid; D004151:Dipeptides / Q000032:analysis / Q000138:chemical synthesis* / Q000737:chemistry; D004951:Esterification; D009980:Influenza A virus / Q000737:chemistry; D007536:Isomerism; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000032:analysis / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D004151:Dipeptides; D009842:Oligopeptides