Current concepts in normal and defective angiogenesis: implications for systemic sclerosis.
Vascular abnormalities are a major component of systemic sclerosis, but little is known about the events or mechanisms that initiate vascular injury and prevent its repair. Early stages of systemic sclerosis are characterized by an exaggerated angiogenic response later replaced by defective wound healing and fibrosis. In this review, we summarize the current knowledge of the angiogenic imbalance in systemic sclerosis.
Mulligan-Kehoe
Mary Jo
MJ
Section of Cardiology, Dartmouth-Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH 03756, USA.
Simons
Michael
M
D003238:Connective Tissue / Q000098:blood supply / Q000473:pathology; D006801:Humans; D009389:Neovascularization, Pathologic / Q000503:physiopathology*; D018919:Neovascularization, Physiologic; D012595:Scleroderma, Systemic / Q000150:complications / Q000503:physiopathology*; D014945:Wound Healing