Evidence mounts for a role of the kidney in lipoprotein(a) catabolism.
Numerous studies have suggested a role of the kidney in lipoprotein(a) (Lp(a)) catabolism, but direct evidence is still lacking. Frischmann et al. demonstrate that the marked elevation of Lp(a) observed in hemodialysis patients results from a decrease in Lp(a) clearance rather than an increase in Lp(a) production, consistent with the notion that the kidney degrades Lp(a). More studies are needed to prove the biological relevance.
Albers
J J
JJ
Northwest Lipid Metabolism and Diabetes Research Laboratories, Department of Medicine, University of Washington, Seattle, Washington 98109, USA.
Koschinsky
M L
ML
Marcovina
S M
SM
D006801:Humans; D007668:Kidney / Q000378:metabolism*; D017270:Lipoprotein(a) / Q000378:metabolism*; D008660:Metabolism / Q000502:physiology; D006435:Renal Dialysis
D017270:Lipoprotein(a)