title: Molecular determinants of invasion in endometrial cancer.
abstract: Endometrial carcinoma is the most common gynaecological malignancy in the western world and the most frequent among infiltrating tumours of the female genital tract. Despite the characterisation of molecular events associated with the development of endometrial carcinoma, those associated with the early steps of infiltration and invasion in endometrial cancer are less known. Deep myometrial invasion correlates with more undifferentiated tumours, lymph-vascular invasion, node affectation and decreased global survival. In this review we present an overview of the molecular pathology of myometrial infiltration that defines the initial steps of invasion in endometrial cancer. Down-regulation of E-cadherin as a main player of epithelial to mesenchymal transition, as well as modifications on other molecules involved in cell-cell contacts, render cells with a migratory phenotype. In addition, altered signalling pathways and transcription factors associate with myometrial invasion, histologic grade and metastasis.
authors.affiliation: Biomedical Research Unit, Research Institute Vall d'Hebron University Hospital, Barcelona, Spain. mabal@ir.vhebron.net
authors.forename: M
authors.initials: M
authors.lastname: Abal
authors.forename: M
authors.initials: M
authors.lastname: Llauradó
authors.forename: A
authors.initials: A
authors.lastname: Doll
authors.forename: M
authors.initials: M
authors.lastname: Monge
authors.forename: E
authors.initials: E
authors.lastname: Colas
authors.forename: M
authors.initials: M
authors.lastname: González
authors.forename: M
authors.initials: M
authors.lastname: Rigau
authors.forename: H
authors.initials: H
authors.lastname: Alazzouzi
authors.forename: S
authors.initials: S
authors.lastname: Demajo
authors.forename: J
authors.initials: J
authors.lastname: Castellví
authors.forename: A
authors.initials: A
authors.lastname: García
authors.forename: S
authors.initials: S
authors.lastname: Ramón y Cajal
authors.forename: J
authors.initials: J
authors.lastname: Xercavins
authors.forename: M H
authors.initials: MH
authors.lastname: Vázquez-Levin
authors.forename: F
authors.initials: F
authors.lastname: Alameda
authors.forename: A
authors.initials: A
authors.lastname: Gil-Moreno
authors.forename: J
authors.initials: J
authors.lastname: Reventos
mesh_terms: D015815:Cell Adhesion Molecules / Q000502:physiology; D016889:Endometrial Neoplasms / Q000209:etiology* / Q000235:genetics / Q000473:pathology*; D005260:Female; D015870:Gene Expression; D006801:Humans; D009361:Neoplasm Invasiveness
chemical_list: D015815:Cell Adhesion Molecules