Microbial production of 1,3-propanediol from glycerol by Klebsiella pneumoniae under micro-aerobic conditions up to a pilot scale.
1,3-Propanediol (1,3-PD) can be produced from glycerol by Klebsiella pneumoniae under micro-aerobic conditions. Recently, this fed-batch fermentation process has been successfully scaled up to 1 m(3). The final 1,3-PD concentration, molar yield and volumetric productivity of 72 g l(-1), 57% and 2.1 g l(-1 )h(-1), respectively, are close to those of 75 g l(-1), 61%, and 2.2 g l(-1 )h(-1) under anaerobic conditions. This process would be suitable for the production of 1,3-PD on a large scale.
Liu
Hai-Jun
HJ
Department of Bioscience and Biotechnology, Dalian University of Technology, Dalian, 116024, P.R. China.
Zhang
Dai-Jia
DJ
Xu
You-Hai
YH
Mu
Ying
Y
Sun
Ya-Qin
YQ
Xiu
Zhi-Long
ZL
D019149:Bioreactors; D001709:Biotechnology / Q000295:instrumentation* / Q000379:methods*; D002623:Chemistry Techniques, Analytical / Q000379:methods; D003470:Culture Media / Q000378:metabolism; D004867:Equipment Design; D005285:Fermentation; D005990:Glycerol / Q000737:chemistry* / Q000378:metabolism; D007711:Klebsiella pneumoniae / Q000378:metabolism*; D011409:Propylene Glycols / Q000737:chemistry* / Q000378:metabolism; D013997:Time Factors
D003470:Culture Media; D011409:Propylene Glycols; C041787:1,3-propanediol; D005990:Glycerol