title: Pulse wave velocity as a marker of arteriosclerosis and its comorbidities in Chinese patients.
abstract: To obtain reliable data on the epidemiology of arteriosclerosis and the comorbidities in patients with hypertension (HP), coronary heart disease (CHD), type 2 diabetes mellitus (T2DM) and stroke, we evaluated the clinical significance of pulse wave velocity (PWV) as an indicator of arteriosclerosis and its comorbidities in Chinese patients. A total of 910 subjects, including 748 Chinese patients with one or more cardiovascular risk factors (80.2% male, mean age 73.69+/-5.03 years) and 162 healthy volunteers (78.4% male, mean age 73.60+/-5.32 years) were recruited into the study. PWV was measured in 910 subjects, and large artery arteriosclerosis was defined as PWV >or=12 m/s. Multivariable logistic regression analyses were performed to identify risk factors associated with arteriosclerosis. The prevalence of large artery arteriosclerosis in the patients overall was 67.4%, and the prevalence was higher in patients with than in those without HP (63.3% vs. 34.0%; odds ratio [OR]: 3.451), T2DM (24.8% vs. 11.1%; OR: 2.854), CHD (56.1% vs. 45.1%; OR: 1.246) and stroke (26.6% vs. 19.2%; OR: 1.236), but the OR values of CHD and stroke did not differ significantly (p>0.05). After multiple logistic regression analysis, female sex, older age, HP and T2DM were risk factors for large artery arteriosclerosis. In conclusion, PWV can be used as a routine measurement to scan arteriosclerosis in patients with HP or T2DM.
authors.affiliation: Department of Geriatrics, Qi-Lu Hospital of Shandong University, Jinan, PR China.
authors.forename: Xiao-Ning
authors.initials: XN
authors.lastname: Liu
authors.forename: Hai-Qing
authors.initials: HQ
authors.lastname: Gao
authors.forename: Bao-Ying
authors.initials: BY
authors.lastname: Li
authors.forename: Mei
authors.initials: M
authors.lastname: Cheng
authors.forename: Ya-Bing
authors.initials: YB
authors.lastname: Ma
authors.forename: Zhi-Mian
authors.initials: ZM
authors.lastname: Zhang
authors.forename: Xi-Mei
authors.initials: XM
authors.lastname: Gao
authors.forename: Yuan-Ping
authors.initials: YP
authors.lastname: Liu
authors.forename: Min
authors.initials: M
authors.lastname: Wang
mesh_terms: D000368:Aged; D001161:Arteriosclerosis / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology*; D015415:Biomarkers; D001794:Blood Pressure / Q000502:physiology*; D002339:Carotid Arteries / Q000502:physiology; D002681:China / Q000453:epidemiology; D015897:Comorbidity; D003327:Coronary Disease / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology*; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology*; D005260:Female; D005263:Femoral Artery / Q000502:physiology; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology; D008297:Male; D012039:Regional Blood Flow / Q000502:physiology; D012307:Risk Factors; D020521:Stroke / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology*
chemical_list: D015415:Biomarkers