title: [The curative effect of corticosteroid on acute otitis media with middle ear effusion].
abstract: OBJECTIVE
  To investigate the curative effect of corticosteroid on acute otitis media (AOM) with middle ear effusion.
  
  
  METHODS
  Forty-three children (43 ears) with AOM and abnormal tympanogram were enrolled in a prospective, randomized trial. Twenty-three cases (23 ears) were treated with Dexamethasone and Cefuroxime Sodium, while the other 20 cases (20 ears) were only treated with Cefuroxime Sodium.
  
  
  RESULTS
  The period of normalization of tympanometric findings in Dexamethasone treatment group was (54.6+/-6.2) days, which was much longer than that in the group without Dexamethasone treatment (38.5+/-6.1). Three months after treatment, the curative rate of Dexamethasone treatment group was higher than that of the group without Dexamethasone treatment.
  
  
  CONCLUSIONS
  Corticosteroid can obviously improve middle ear effusion and shorten the duration of middle ear effusion of AOM in the first 2 weeks. To some extent, corticosteroid can also improve middle ear effusion in long term. It indicates that corticosteroid be used as an effective adjunctive drug in treating AOM with middle ear effusion.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
authors.forename: Chunfang
authors.initials: C
authors.lastname: Wang
authors.forename: Zheng
authors.initials: Z
authors.lastname: Liu
authors.forename: Xiaowen
authors.initials: X
authors.lastname: Huang
authors.forename: Kai
authors.initials: K
authors.lastname: Xu
mesh_terms: D002648:Child; D002675:Child, Preschool; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D007223:Infant; D008297:Male; D010033:Otitis Media / Q000188:drug therapy*; D010034:Otitis Media with Effusion / Q000188:drug therapy*; D011446:Prospective Studies
chemical_list: D005938:Glucocorticoids