Cognitive reserve and neuropsychological functioning in patients infected with hepatitis C.
This study evaluated the influence of cognitive reserve on neuropsychological test performance in 198 patients infected with the hepatitis C virus. IQ scores, educational level, and occupational rating were combined to calculate a Cognitive Reserve Score (CRS) for each patient. Similar to studies of infection with the human immunodeficiency virus, there was a significantly increased risk of impairment in neuropsychological test performance in individuals with lower CRSs. It is important to account for CRS when assessing cognitive findings in large-scale clinical trials.
Bieliauskas
Linas A
LA
Neuropsychology Section, Department of Psychiatry, University of Michigan Medical Center, Ann Arbor, Michigan 48105, USA. linas@umich.edu
Back-Madruga
Carla
C
Lindsay
Karen L
KL
Wright
Elizabeth C
EC
Kronfol
Ziad
Z
Lok
Anna S F
AS
Fontana
Robert J
RJ
D000328:Adult; D016009:Chi-Square Distribution; D003071:Cognition / Q000502:physiology*; D003072:Cognition Disorders / Q000453:epidemiology / Q000209:etiology* / Q000821:virology; D004522:Educational Status; D004651:Employment; D005260:Female; D005500:Follow-Up Studies; D006526:Hepatitis C / Q000150:complications* / Q000453:epidemiology; D006801:Humans; D007360:Intelligence; D008297:Male; D008606:Mental Processes; D008875:Middle Aged; D009048:Motor Skills; D009483:Neuropsychological Tests; D010555:Personality Inventory; D011340:Problem Solving; D012306:Risk