title: Diabetes mellitus and kidney cancer risk: the results of Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC Study).
abstract: BACKGROUND
  Diabetes mellitus (DM) is reported as being a risk factor associated with kidney cancer in Western countries. The incidence of both kidney cancer and DM is lower in Japan than the other developed countries, albeit on the rise.
  
  
  METHODS
  We evaluated the risk factors for kidney cancer mortality using the database of the Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC) study. The analytic cohort included 46 462 males and 64 326 females aged 40-79 years old. The Cox proportional hazards model was used to determine age- and sex-adjusted relative risk and its 95% confidence intervals.
  
  
  RESULTS
  DM showed an increased, age- and sex-adjusted hazard ratio for kidney cancer mortality, but it failed to achieve statistical significance after controlling for other factors.
  
  
  CONCLUSIONS
  The present study showed that DM increased the risk of kidney cancer death among the Japanese population. However, further studies may be needed to confirm the findings in the present study because DM failed to remain as a significant risk factor after controlling for other factors because of the small number of kidney cancer deaths in the present study.
authors.affiliation: Department of Public Health, Sapporo Medical University School of Medicine, Sapporo, Japan. washio@st-mary.ac.jp
authors.forename: Masakazu
authors.initials: M
authors.lastname: Washio
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Mori
authors.forename: Mmh
authors.initials: M
authors.lastname: Khan
authors.forename: Fumio
authors.initials: F
authors.lastname: Sakauchi
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Watanabe
authors.forename: Kotaro
authors.initials: K
authors.lastname: Ozasa
authors.forename: Kyohei
authors.initials: K
authors.lastname: Hayashi
authors.forename: Tsuneharu
authors.initials: T
authors.lastname: Miki
authors.forename: Masahiro
authors.initials: M
authors.lastname: Nakao
authors.forename: Kazuya
authors.initials: K
authors.lastname: Mikami
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Ito
authors.forename: Tatsuhiko
authors.initials: T
authors.lastname: Kubo
authors.forename: Kenji
authors.initials: K
authors.lastname: Wakai
authors.forename: Akiko
authors.initials: A
authors.lastname: Tamakoshi
mesh_terms: D048909:Diabetes Complications / Q000209:etiology*; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000209:etiology*; D008297:Male; D018570:Risk Assessment; D012307:Risk Factors