title: Immune responses against measles virus in cynomolgus monkeys.
abstract: Measles virus (MV) induces profound suppression of the immune response during and for weeks after acute infection. On the other hand, virus-specific immune responses that mediate viral clearance and confer long-lasting immunity are efficiently generated. To investigate this paradox, we studied the immune responses to MV using a monkey model of acute measles. Cynomolgus monkeys were experimentally infected with wild-type MV (MV-HL) and showed marked leukopenia associated with a steady reduction in CD4+ T cell numbers for 18 days post-inoculation. Transient expression of interferon and IL-6 were observed in the serum between 4 and 6 days post-inoculation, and IL-10 levels increased after 11 days post-inoculation. Interestingly, IL-8 showed a three-peak increase that correlated with an increase in neutrophils. A non-human primate model of measles allows the early immune response against MV to be studied in more detail.
authors.affiliation: Laboratory Animal Research Center, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Sato
authors.forename: Fumio
authors.initials: F
authors.lastname: Kobune
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Ami
authors.forename: Misako
authors.initials: M
authors.lastname: Yoneda
authors.forename: Chieko
authors.initials: C
authors.lastname: Kai
mesh_terms: D000818:Animals; D016207:Cytokines / Q000378:metabolism; D008252:Macaca fascicularis / Q000276:immunology*; D008457:Measles / Q000276:immunology* / Q000821:virology*; D008459:Measles virus / Q000276:immunology*; D009504:Neutrophils / Q000378:metabolism; D016176:T-Lymphocyte Subsets / Q000276:immunology / Q000378:metabolism; D013997:Time Factors
chemical_list: D016207:Cytokines