title: Risk of target lesion revascularization after coronary stenting in patients with and without chronic kidney disease.
abstract: BACKGROUND
  Rates of restenosis following percutaneous coronary intervention with stent placement are high in patients with advanced renal failure. Whether mild to moderate chronic kidney disease (CKD) is associated with a similarly increased need for short or long-term target lesion revascularization (TLR) following coronary stenting is uncertain.
  
  
  METHODS
  We analysed results from 1228 patients enrolled in four separate, randomized, controlled clinical trials who underwent elective coronary angioplasty with stenting and were prospectively followed for 5 years after the index procedure. Cox proportional hazards regression was used to correct for confounding and to estimate the short and long-terms risks of target lesion revascularization in patients with vs without mild to moderate CKD.
  
  
  RESULTS
  During a median follow-up of 5 years, 205 patients (16.7%) required TLR with 59 (4.8%) requiring TLR after the first year. Mild (HR 1.07, 95% CI 0.74-1.53) and moderate (HR 0.95, 95% CI 0.552-1.64) CKD were not associated with an increase in the adjusted, overall-risk of TLR. However, mild to moderate CKD was associated with a non-significantly increased risk of late TLR (HR 1.40, 95% CI 0.73-2.69).
  
  
  CONCLUSIONS
  Coronary stenting appears to be similarly effective in patients with mild to moderate CKD and patients with normal renal function. While target lesion revascularization is rarely needed beyond the first year after revascularization, long-term results of coronary stenting may be less-favourable in patients with CKD.
authors.affiliation: Department of Medicine, Brigham and Women's Hospital, Renal Division, Clinical Biometrics, 1 Brigham Circle, 3rd Floor, Boston, MA 02115, USA. dcharytan@partners.org
authors.forename: David
authors.initials: D
authors.lastname: Charytan
authors.forename: John P
authors.initials: JP
authors.lastname: Forman
authors.forename: Donald E
authors.initials: DE
authors.lastname: Cutlip
mesh_terms: D023903:Coronary Restenosis / Q000503:physiopathology; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000503:physiopathology; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged; D009204:Myocardial Revascularization / Q000379:methods*; D009206:Myocardium / Q000473:pathology*; D012307:Risk Factors; D015607:Stents; D013997:Time Factors