title: Compound Hub: efficiency gains through innovative sample management processes.
abstract: While significant investments are made across the industry and increasingly also in academia to enhance or build a compound file, the efficient sourcing of compounds from in-house medical chemistry is frequently seen as a challenge. This article introduces the Compound Hub strategy developed at the Novartis Compound Archive. Central Compound Hubs in Basel and Cambridge were combined with web-based ordering of compounds and assays, providing assay-ready, solubilized samples to labs anywhere in the global research organization. Relieving scientists from time-intensive sample preparation tasks, error rates could be reduced through electronic processing and tracking of compounds/assays and the capture of medicinal chemistry compounds for the compound library could be increased by 75%.
authors.affiliation: Novartis Institutes for BioMedical Research, Discovery Technologies, Basel, Switzerland. ulrich.schopfer@novartis.com
authors.forename: Ulrich
authors.initials: U
authors.lastname: Schopfer
authors.forename: Marc R M
authors.initials: MR
authors.lastname: Andreae
authors.forename: Matthieu
authors.initials: M
authors.lastname: Hueber
authors.forename: Andreas
authors.initials: A
authors.lastname: Saur
authors.forename: Marcel O
authors.initials: MO
authors.lastname: Kummer
authors.forename: Michel
authors.initials: M
authors.lastname: Girod
authors.forename: Desmond
authors.initials: D
authors.lastname: Fox
authors.forename: Thomas
authors.initials: T
authors.lastname: Steiner
authors.forename: Maxim
authors.initials: M
authors.lastname: Popov
authors.forename: Robert
authors.initials: R
authors.lastname: Smith
mesh_terms: D020650:Combinatorial Chemistry Techniques / Q000295:instrumentation* / Q000379:methods*; D017076:Computer-Aided Design; D016208:Databases, Factual; D004353:Drug Evaluation, Preclinical / Q000379:methods; D020407:Internet; D046609:Libraries, Digital