Photoselective vaporization of the prostate with the potassium-titanyl-phosphate laser in men with prostates of >100 mL.
OBJECTIVE
To assess the efficacy of photoselective vaporization of the prostate (PVP) in men with prostates of >100 mL and causing bladder outlet obstruction (BOO), using the high-power 80 W potassium-titanyl-phosphate laser (GreenLight PV, Laserscope, San Jose, CA, USA), which offers rapid tissue ablation with minimal bleeding.


METHODS
We assessed 54 consecutive patients with prostates of >100 mL (mean 135, SD 42, range 100-300) who had PVP between May 2003 and August 2005. Evaluations before PVP included urine flowmetry, the International Prostate Symptom Score (IPSS), a quality-of life (QoL) score, prostate-specific antigen (PSA) level, and prostate volume measured by transrectal ultrasonography (TRUS).


RESULTS
The mean (SD, range) duration of PVP was 81.6 (22.9, 39-150) min, the mean energy used for PVP was 278 (60, 176-443) kJ and the mean duration of catheterization after PVP was 23.0 (17.1, 0-72) h. The mean (sd) maximum urinary flow rate improved from 8.0 (3.1) to 18.2 (8.1), 18.5 (9.2), 17.9 (7.8) and 19.3 (9.8) mL/s at 3, 6, 12 and 24 months, respectively. The IPSS and QoL scores showed similar improvements, and there was a statistically significant reduction in PSA level and prostate volume after PVP. There was no major complication and no patient had transurethral resection syndrome or a blood transfusion.


CONCLUSIONS
The 80 W KTP laser PVP offers rapid tissue ablation in patients with BOO caused by a large prostate. The short- and medium-term outcomes show that this technique can be a viable alternative to open prostatectomy.
Rajbabu
Krishnamoorthy
K
Department of Urology, King's College Hospital, Denmark Hill, London, UK. bangarubabu72@hotmail.com
Chandrasekara
Srinath K
SK
Barber
Neil J
NJ
Walsh
Kilian
K
Muir
Gordon H
GH
D000368:Aged; D000369:Aged, 80 and over; D006801:Humans; D053685:Laser Therapy / Q000379:methods / Q000592:standards*; D008297:Male; D008875:Middle Aged; D010710:Phosphates; D011183:Postoperative Complications / Q000209:etiology; D017680:Potassium Compounds; D011446:Prospective Studies; D011467:Prostate / Q000473:pathology; D011468:Prostatectomy / Q000379:methods*; D011470:Prostatic Hyperplasia / Q000150:complications / Q000473:pathology / Q000601:surgery*; D011788:Quality of Life; D012008:Recurrence; D012086:Reoperation; D016896:Treatment Outcome; D001748:Urinary Bladder Neck Obstruction / Q000209:etiology / Q000601:surgery*
D010710:Phosphates; D017680:Potassium Compounds; C013216:potassium phosphate