Iriomoteolide-1a, a potent cytotoxic 20-membered macrolide from a benthic dinoflagellate amphidinium species.
A potent cytotoxic 20-membered macrolide, iriomoteolide-1a (1), has been isolated from a benthic dinoflagellate Amphidinium sp. (strain HYA024), and the structure was elucidated on the basis of detailed analyses of 2-D NMR data. The relative and absolute stereochemistries were assigned by the combination of conformational analyses using NMR data and modified Mosher's method of 1.
Tsuda
Masashi
M
Center for Advanced Marine Core Research, Kochi University, Kochi 783-8502, Japan. mtsuda@kochi-u.ac.jp
Oguchi
Keiko
K
Iwamoto
Rie
R
Okamoto
Yumiko
Y
Kobayashi
Jun'ichi
J
Fukushi
Eri
E
Kawabata
Jun
J
Ozawa
Tomoko
T
Masuda
Atsunori
A
Kitaya
Yoshiaki
Y
Omasa
Kenji
K
D000818:Animals; D004141:Dinoflagellida / Q000737:chemistry*; D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry / Q000302:isolation & purification; D008958:Models, Molecular; D008968:Molecular Conformation; D019906:Nuclear Magnetic Resonance, Biomolecular
D018942:Macrolides; C520799:iriomoteolide-1a