title: Topical therapy in the treatment of actinic keratosis and basal cell carcinoma.
abstract: Actinic keratosis (AK) is an evolving malignant cutaneous neoplasm. AK also is known as solar keratosis and squamous cell carcinoma (SCC) in situ, either solar keratotic type or keratinocytic intraepidermal neoplasia. AKs can be treated with destructive or topical therapies. This article reviews current and evolving topical therapeutic options for AKs, several of which have been shown to offer substantial benefit in the alleviation of these lesions. The topical therapies include 5-fluorouracil (5-FU), diclofenac sodium, colchicine, retinoids, and imiquimod. Topical treatment of basal cell carcinoma (BCC) with imiquimod also will be discussed.
authors.affiliation: Department of Dermatology, UMDNJ-Robert Wood Johnson Medical School, Newark, USA.
authors.forename: Marissa D
authors.initials: MD
authors.lastname: Newman
authors.forename: Jeffrey M
authors.initials: JM
authors.lastname: Weinberg
mesh_terms: D000279:Administration, Cutaneous; D000970:Antineoplastic Agents / Q000008:administration & dosage; D002280:Basal Cell Carcinoma / Q000188:drug therapy*; D016861:Cyclooxygenase Inhibitors / Q000008:administration & dosage; D006801:Humans; D007642:Keratosis / Q000188:drug therapy*; D012176:Retinoids / Q000008:administration & dosage; D012878:Skin Neoplasms / Q000188:drug therapy*; D050257:Tubulin Modulators / Q000008:administration & dosage
chemical_list: D000970:Antineoplastic Agents; D016861:Cyclooxygenase Inhibitors; D012176:Retinoids; D050257:Tubulin Modulators