Pediatric thyroid cancer arising after treatment for pleuropulmonary blastoma.
A 3-year-old female presented with a large tumor occupying the right thoracic space. Open biopsy revealed the pathological diagnosis of pleuropulmonary blastoma. After the first-line chemotherapy, the patient underwent surgical resection, then two courses of high-dose chemotherapy. Three years later, follicular carcinoma of the right thyroid lobe was found, so a right hemithyroidectomy was performed. Five months later, the thyroid tumor recurred. The remaining thyroid lobe was completely excised and radioiodine therapy was administered. The patient has remained tumor-free for 3 years. The etiology and treatment of the uncommon combination of pleuropulmonary blastoma and thyroid carcinoma is discussed.
Oue
Takaharu
T
Department of Surgery, Division of Pediatric Surgery, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan. ooue@pedsurg.med.osaka-u.ac.jp
Inoue
Masami
M
Kubota
Akio
A
Kuwae
Yuko
Y
Kawa
Keisei
K
D018263:Adenocarcinoma, Follicular / Q000473:pathology* / Q000628:therapy; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use; D008175:Lung Neoplasms / Q000188:drug therapy / Q000473:pathology*; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000628:therapy; D016609:Neoplasms, Second Primary / Q000473:pathology* / Q000628:therapy; D010997:Pleural Neoplasms / Q000188:drug therapy / Q000473:pathology; D018202:Pulmonary Blastoma / Q000188:drug therapy / Q000473:pathology*; D013510:Pulmonary Surgical Procedures; D013964:Thyroid Neoplasms / Q000473:pathology* / Q000628:therapy
D007457:Iodine Radioisotopes