title: Influenza vaccination for severely multiply handicapped persons/children in the 2005-2006 season.
abstract: In this study, we report the effectiveness of trivalent inactivated influenza vaccination (TIV) for severely multiply handicapped persons/children (SMHPs) in the 2005-2006 season. In 77 SMHPs, A/New York/55/2004 (H3N2) which was the changed vaccine-strain showed significant differences in the geometric mean titers (P<0.05) and seroprotection rates (P<0.01) between pre- and post-vaccination. A/New Caledonia/20/99 (H1N1) and B/Shanghai/361/2002, which were the unchanged vaccine-strains, showed no significant differences. We defined the potential responders as those who can achieve 1:40 or more hemagglutination inhibition (HAI) titer after vaccination with any vaccine-strain. Therefore, the rate of potential responders is equivalent to the rate of seroprotection, estimated to be 40-60% among the SMHPs and >80% among the control group in this study. In the SMHPs, even potential responders could only achieve limited HAI titers (1:40-80) even after repeated vaccination. In contrast, the control group showed higher HAI titers compared to the SMHPs for the unchanged vaccine-strains caused by the priming effect. These data suggest that it might be difficult for SMHPs (including potential responders) to achieve the priming effect by the current TIV. Consequently, they cannot obtain a booster effect.
authors.affiliation: Department of Pediatrics, Niigata National Hospital, 3-52, Akasaka-Cho, Kashiwazaki, Niigata 945-8585, Japan. ootsukataketo@hotmail.com
authors.forename: Taketo
authors.initials: T
authors.lastname: Otsuka
authors.forename: Hidehiko
authors.initials: H
authors.lastname: Fujinaka
authors.forename: Koichi
authors.initials: K
authors.lastname: Katsuyama
authors.forename: Masashi
authors.initials: M
authors.lastname: Iizawa
authors.forename: Satoru
authors.initials: S
authors.lastname: Kinoshita
authors.forename: Yasuki
authors.initials: Y
authors.lastname: Tanaka
authors.forename: Reiko
authors.initials: R
authors.lastname: Saito
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Suzuki
authors.forename: Shuichi
authors.initials: S
authors.lastname: Tomizawa
mesh_terms: D000328:Adult; D000368:Aged; D002648:Child; D019988:Children with Disabilities; D006233:Persons with Disabilities; D005260:Female; D006801:Humans; D053122:Influenza A Virus, H3N2 Subtype / Q000276:immunology*; D007252:Influenza Vaccines / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D014611:Vaccination
chemical_list: D007252:Influenza Vaccines