title: Clinical management of symptom clusters.
abstract: OBJECTIVE
  To discuss the current evidence for the management of symptoms in clusters and future directions in symptom cluster management research.
  
  
  METHODS
  Research and review articles.
  
  
  CONCLUSIONS
  Currently no research has been reported on management of formally identified symptom clusters in oncology. Several researchers have described psychoeducational and exercise interventions that have decreased multiple concurrent symptoms. Understanding common biological mechanisms that underlie symptom clusters, such as inflammatory pathways, may suggest more effective treatments for symptom clusters.
  
  
  CONCLUSIONS
  Clinicians and researchers need to collaborate to better understand symptom clusters and develop effective interventions.
authors.affiliation: Department of Symptom Research, University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA. lowillia@mdanderson.org
authors.forename: Loretta A
authors.initials: LA
authors.lastname: Williams
mesh_terms: D016000:Cluster Analysis; D006801:Humans; D009369:Neoplasms / Q000503:physiopathology*; D010353:Patient Education as Topic