A new episodic ataxia syndrome with linkage to chromosome 19q13.
BACKGROUND
Multiple episodic ataxia phenotypes and genotypes have been described.


OBJECTIVE
To describe a new episodic ataxia syndrome.


METHODS
Genomewide linkage analysis with dense single nucleotide polymorphism arrays.


METHODS
University clinic. Patients Family with lifelong episodes of ataxia and normal interictal examination results.


RESULTS
Suggestive linkage (logarithm of odds score, 3.27) to a 10-centimorgan region on chromosome 19q13.


CONCLUSIONS
A new dominantly inherited episodic ataxia syndrome is linked to chromosome 19q.
Kerber
Kevin A
KA
Department of Neurology, UCLA, Los Angeles, California 90095-1769, USA.
Jen
Joanna C
JC
Lee
Hane
H
Nelson
Stanley F
SF
Baloh
Robert W
RW
D000369:Aged, 80 and over; D001259:Ataxia / Q000235:genetics*; D002874:Chromosome Mapping; D002888:Chromosomes, Human, Pair 19; D005260:Female; D005838:Genotype; D006801:Humans; D016017:Odds Ratio; D010375:Pedigree; D010641:Phenotype