Synthesis of neutral and cationic tripyridylporphyrin-D-galactose conjugates and the photoinactivation of HSV-1.
Neutral and cationic tripyridylporphyrin-D-galactose conjugates were synthesized and their antiviral activity against herpes simplex virus type 1 (HSV-1) was evaluated. At non-cytotoxic concentrations the studied compounds show significant antiviral activity after photoactivation. The influence of photoactivation on drug treated cells was also analyzed, at different times of infection with HSV-1, for a neutral (1b) and a cationic glycoporphyrin (3b) derivative. The results show that the inhibition of the viral yield is more dependent on photoactivation for compound 1b than for compound 3b. These two compounds also differ in the inhibitory effect during the viral replicative cycle: while compound 3b inhibits the viral yield at all the addition times assayed, compound 1b is more efficient in later times of infection.
Tomé
João P C
JP
Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal.
Silva
Eduarda M P
EM
Pereira
Ana M V M
AM
Alonso
Cristina M A
CM
Faustino
Maria A F
MA
Neves
Maria G P M S
MG
Tomé
Augusto C
AC
Cavaleiro
José A S
JA
Tavares
Sabina A P
SA
Duarte
Ricardo R
RR
Caeiro
Maria F
MF
Valdeira
Maria L
ML
D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D002412:Cations / Q000138:chemical synthesis / Q000737:chemistry; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D002522:Chlorocebus aethiops; D005690:Galactose / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D018259:Herpesvirus 1, Human / Q000187:drug effects* / Q000502:physiology / Q000528:radiation effects; D015394:Molecular Structure; D017319:Photosensitizing Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D011166:Porphyrins / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry*; D026082:Singlet Oxygen / Q000737:chemistry; D055672:Static Electricity; D013329:Structure-Activity Relationship; D013997:Time Factors; D014709:Vero Cells
D000998:Antiviral Agents; D002412:Cations; D017319:Photosensitizing Agents; D011166:Porphyrins; D011725:Pyridines; D026082:Singlet Oxygen; C023666:pyridine; D005690:Galactose