[Natural products in clinical trials: antibacterial and antifungal agents].
Natural products have played an important role in drug discovery. Today, therapeutics from natural origin count for about 70% of the worldwide human therapeutic sales. For anti-infective treatment even higher figures are reported. This review describes antibacterial and antifungal natural products, semi-synthetic natural products and natural product derived compounds undergoing clinical evaluation or registration from 1998 to end of 2005. In addition, natural product derived drugs launched since 1998 are also discussed in this review.
Han
Li
L
School of Pharmaceutical Sciences, China Medical University, Shenyang 110001, China.
Zheng
Dan
D
Huang
Xue-Shi
XS
Yu
Shi-Shan
SS
Liang
Xiao-Tian
XT
D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry* / Q000494:pharmacology; D001688:Biological Products / Q000737:chemistry* / Q000494:pharmacology; D004352:Drug Resistance, Microbial; D015507:Drugs, Investigational / Q000737:chemistry* / Q000494:pharmacology; D054714:Echinocandins / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D015394:Molecular Structure; D011090:Polyenes / Q000737:chemistry / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D001688:Biological Products; D015507:Drugs, Investigational; D054714:Echinocandins; D011090:Polyenes; C100293:partricin