[Clinical research of Yiqi Sanju Formula in treating central obese men at high risk of metabolic syndrome].
OBJECTIVE
To observe the therapeutic effects of Yiqi Sanju Formula (YQSJF), a compound Chinese herbal medicine, on central obese men at high risk of metabolic syndrome (MS).


METHODS
Compared with 30 healthy male volunteers, 45 central obese men were separated randomly into two groups and received the interventions with YQSJF and placebo respectively for 10 weeks. Baseline characteristics, insulin resistance, inflammation cytokines and plasminogen activator inhibitor-1 (PAI-1) and tissue plasminogen activator (t-PA) were evaluated before and after treatment.


RESULTS
The score of homeostatic model assessment for insulin resistance (HOMA-IR) and the levels of C reactive protein (CRP), free fatty acid (FFA) and PAI-1 in obese men were higher than those in the control group, while t-PA was lower. After treatment, compared with placebo group, body mass index, waist, and waist-to-hip ratio were decreased significantly in subjects who received YQSJF (P<0.01). The score of HOMA-IR and the levels of CRP, FFA and PAI-1 were decreased significantly, and the level of t-PA was increased significantly (P<0.01).


CONCLUSIONS
YQSJF can reduce obesity and insulin resistance in central obese men at high risk of MS and improve inflammation and fibrinolysis, which indicates that it can reduce the risk of atherosclerosis.
He
Chun-yan
CY
Institute of Chinese Integrative Medicine, Fudan University, Shanghai 200040, China.
Wang
Wen-jian
WJ
Li
Bin
B
Xu
De-sheng
DS
Chen
Wei-hua
WH
Ying
Jiang
J
He
Yan-ming
YM
D000328:Adult; D002097:C-Reactive Protein / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005227:Fatty Acids / Q000097:blood; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D024821:Metabolic Syndrome / Q000209:etiology / Q000517:prevention & control*; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D008517:Phytotherapy; D012307:Risk Factors; D016896:Treatment Outcome
D004365:Drugs, Chinese Herbal; D005227:Fatty Acids; C528001:Yiqi Sanju formula; D002097:C-Reactive Protein