title: Protein-protein interaction inhibitors: small molecules from screening techniques.
abstract: Protein-protein interactions play crucial roles in a number of biological processes, and, as such, their disruption is becoming an area of intense research. Despite the many challenges associated with the development of protein-protein interaction inhibitors, such as the large and relatively featureless interfacial areas involved, there has been considerable success in recent years. Importantly, through the existence of protein "hot spots", some of this success takes the form of small molecule inhibitors that have been identified from a variety of screening techniques.
authors.affiliation: Department of Chemistry, Yale University, P.O. Box 208107, New Haven, CT 06520-8107, USA.
authors.forename: Steven
authors.initials: S
authors.lastname: Fletcher
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Hamilton
mesh_terms: D000818:Animals; D001665:Binding Sites; D045744:Cell Line, Tumor; D015195:Drug Design; D006801:Humans; D018716:Molecular Mimicry; D011485:Protein Binding; D011487:Protein Conformation; D025941:Protein Interaction Mapping; D011506:Proteins / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000235:genetics; D011993:Recombinant Fusion Proteins / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000235:genetics
chemical_list: D011506:Proteins; D011993:Recombinant Fusion Proteins