title: DBH -1021C-->T does not modify risk or age at onset in Parkinson's disease.
abstract: DBH is a candidate gene in Parkinson's disease (PD) and contains a putative functional polymorphism (-1021C-->T) that has been reported to modify PD susceptibility. We examined -1021C-->T in a sample of 1,244 PD patients and 1,186 unrelated control subjects. There was no significant difference in allele (p = 0.14) or genotype (p = 0.26) frequencies between the two groups. A similar result was obtained after pooling our data with those previously published. Furthermore, we found no evidence for an effect of genotype on age at onset among patients. Our findings argue against DBH -1021C-->T as a risk factor or age at onset modifier in PD.
authors.affiliation: Department of Neurology, University of Washington School of Medicine, Seattle, WA 98108, USA.
authors.forename: Lani S
authors.initials: LS
authors.lastname: Chun
authors.forename: Ali
authors.initials: A
authors.lastname: Samii
authors.forename: Carolyn M
authors.initials: CM
authors.lastname: Hutter
authors.forename: Alida
authors.initials: A
authors.lastname: Griffith
authors.forename: John W
authors.initials: JW
authors.lastname: Roberts
authors.forename: Berta C
authors.initials: BC
authors.lastname: Leis
authors.forename: Anthony D
authors.initials: AD
authors.lastname: Mosley
authors.forename: P Luke
authors.initials: PL
authors.lastname: Wander
authors.forename: Karen L
authors.initials: KL
authors.lastname: Edwards
authors.forename: Haydeh
authors.initials: H
authors.lastname: Payami
authors.forename: Cyrus P
authors.initials: CP
authors.lastname: Zabetian
mesh_terms: D017668:Age of Onset; D000368:Aged; D000483:Alleles; D016009:Chi-Square Distribution; D004299:Dopamine beta-Hydroxylase / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000453:epidemiology / Q000235:genetics* / Q000503:physiopathology; D011110:Polymorphism, Genetic; D012306:Risk
chemical_list: D004299:Dopamine beta-Hydroxylase