Skin cancers and precancerous lesions in Parkinson's disease patients.
Our objective was to evaluate the frequency of neoplastic and preneoplastic skin lesions in Parkinson's disease (PD) patients when compared with an aged-matched population. We performed a cross-sectional survey in PD patients and in an age-matched control group. Patients and controls were examined by a movement disorder specialist and a dermatologist. 150 PD patients and 146 controls were included. Thirty-five PD patients (23.3%) presented skin lesions that could be classified as neoplastic or preneoplastic vs. 20 subjects in the control group (13.7%) (OR 95%, CI 1.92 [1.05, 3.51]). However, this difference lost statistical significance when adjusted for gender (recruitment of controls was matched just for age with an over representation of males in the PD group). Twenty-nine PD patients (19%) presented actinic keratosis and basal cell carcinoma was diagnosed in 4 patients (3%). Although nonconclusive, our results are in agreement with previous studies suggesting an increased risk of skin cancer in PD patients. The frequency of actinic keratosis in PD patients and the associated risk to develop melanoma recommends its screening in future epidemiological studies.
Ferreira
Joaquim
J
Neurological Clinic Research Unit, Institute of Molecular Medicine, Lisbon School of Medicine, Lisbon, Portugal.
Silva
João Maia
JM
Dermatology Department, Hospital de Santa Maria, Lisbon, Portugal.
Freire
Rita
R
Neurological Clinic Research Unit, Institute of Molecular Medicine, Lisbon School of Medicine, Lisbon, Portugal.
Pignatelli
João
J
Dermatology Department, Hospital de Santa Maria, Lisbon, Portugal.
Guedes
Leonor Correia
LC
Neurological Clinic Research Unit, Institute of Molecular Medicine, Lisbon School of Medicine, Lisbon, Portugal.
Feijó
Alexandra
A
Dermatology Department, Hospital de Santa Maria, Lisbon, Portugal.
Rosa
Mário Miguel
MM
Neurological Clinic Research Unit, Institute of Molecular Medicine, Lisbon School of Medicine, Lisbon, Portugal.
Coelho
Miguel
M
Neurological Clinic Research Unit, Institute of Molecular Medicine, Lisbon School of Medicine, Lisbon, Portugal.
Costa
João
J
Neurological Clinic Research Unit, Institute of Molecular Medicine, Lisbon School of Medicine, Lisbon, Portugal.
Noronha
Ana
A
Neurological Clinic Research Unit, Institute of Molecular Medicine, Lisbon School of Medicine, Lisbon, Portugal.
Hewett
Russell
R
Neurological Clinic Research Unit, Institute of Molecular Medicine, Lisbon School of Medicine, Lisbon, Portugal.
Gomes
A Marques
AM
Dermatology Department, Hospital de Santa Maria, Lisbon, Portugal.
de Castro
J L Cirne
JLC
Dermatology Department, Hospital de Santa Maria, Lisbon, Portugal.
Rascol
Olivier
O
Clinical Investigation Centre, Department of Clinical Pharmacology and Neurosciences, University Hospital, Toulouse, France.
Sampaio
Cristina
C
Neurological Clinic Research Unit, Institute of Molecular Medicine, Lisbon School of Medicine, Lisbon, Portugal.
D000368:Aged; D016022:Case-Control Studies; D016001:Confidence Intervals; D018592:Cross-Over Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010300:Parkinson Disease / Q000503:physiopathology*; D011230:Precancerous Conditions / Q000503:physiopathology*; D012307:Risk Factors; D012878:Skin Neoplasms / Q000503:physiopathology*; D011795:Surveys and Questionnaires