title: Squamous cell carcinoma arising on a skin graft 64 years after primary injury.
abstract: Malignant degeneration of a chronic wound is often described by the term, Marjolin's ulcer. We present a case of a squamous cell carcinoma that developed in a patient 64 years after the initial injury during World War II. Tissue contusion and detachment required repeated surgery and full skin grafting in several hospitals. The patient had a persistent ulcer in the right popliteal region for the last 3 years. Excisional biopsy in our department showed a bifocal low-grade invasive squamous cell carcinoma of the skin. Because of extensive inflammation and previous scar formation it was difficult to determine the status of the surgical margins. Therefore, we proceeded with amputation at the right thigh. Some 6 months after surgery the general condition of the patient remains excellent.
authors.forename: Nina
authors.initials: N
authors.lastname: Guenther
authors.forename: Charalambos
authors.initials: C
authors.lastname: Menenakos
authors.forename: Chris
authors.initials: C
authors.lastname: Braumann
authors.forename: Rolf
authors.initials: R
authors.lastname: Buettemeyer
mesh_terms: D000368:Aged; D000671:Amputation, Surgical / Q000379:methods; D001707:Biopsy, Needle; D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000601:surgery; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D002921:Cicatrix / Q000473:pathology; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D007869:Leg Injuries / Q000175:diagnosis / Q000601:surgery; D008297:Male; D009367:Neoplasm Staging; D018570:Risk Assessment; D012878:Skin Neoplasms / Q000473:pathology* / Q000601:surgery; D016038:Skin Transplantation / Q000009:adverse effects* / Q000379:methods; D013997:Time Factors; D016896:Treatment Outcome