title: Efficacy of xenogeneic bone grafting with guided tissue regeneration in the management of bone defects after surgical endodontics.
abstract: OBJECTIVE
  The purpose of this prospective clinical trial was to monitor the outcomes of periradicular surgery in large periapical lesions with or without guided tissue regeneration (GTR) and anorganic bovine bone.
  
  
  METHODS
  All teeth in the study revealed a periradicular lesion measuring at least 10 mm. A total of 63 teeth in 44 patients were included according to specific selection criteria. In the test group, after root end filling was completed, the defect was filled with anorganic bovine bone and was covered with a resorbable collagen membrane. In the control group, neither graft nor membrane was used.
  
  
  RESULTS
  A total of 59 teeth in 41 patients were evaluable at 1-year follow-up. Of these, 24 teeth belonged to the test group and 35 to the control group. Overall, 46 teeth (78%) had successfully healed, 10 (16.9%) demonstrated uncertain healing, and 3 exhibited treatment failure. Investigators found no statistically significant differences in outcome between test and control groups.
  
  
  CONCLUSIONS
  The present study showed that the use of GTR in association with anorganic bovine bone in the treatment of patients with large periradicular lesions of strictly endodontic origin has no beneficial effect on outcome.
authors.affiliation: Department of Odontology, Istituto Ortopedico Galeazzi I.R.C.C.S., University of Milan, Milan, Italy.
authors.forename: Silvio
authors.initials: S
authors.lastname: Taschieri
authors.forename: Massimo
authors.initials: M
authors.lastname: Del Fabbro
authors.forename: Tiziano
authors.initials: T
authors.lastname: Testori
authors.forename: Roberto
authors.initials: R
authors.lastname: Weinstein
mesh_terms: D020341:Absorbable Implants; D000328:Adult; D000818:Animals; D001047:Apicoectomy / Q000379:methods*; D001672:Biocompatible Materials; D001857:Bone Matrix / Q000637:transplantation; D016025:Bone Transplantation / Q000379:methods*; D002417:Cattle; D003094:Collagen; D005260:Female; D005500:Follow-Up Studies; D016557:Guided Tissue Regeneration, Periodontal; D006801:Humans; D008297:Male; D008567:Membranes, Artificial; D008903:Minerals / Q000627:therapeutic use; D010483:Periapical Diseases / Q000601:surgery*; D011446:Prospective Studies; D012184:Retrograde Obturation; D014183:Transplantation, Heterologous; D016896:Treatment Outcome; D014945:Wound Healing / Q000502:physiology
chemical_list: C106416:Bio-Gide; C077540:Bio-Oss; D001672:Biocompatible Materials; D008567:Membranes, Artificial; D008903:Minerals; D003094:Collagen