[Liver pathology in idiopathic portal hypertension].
OBJECTIVE
To study the histopathological changes of livers in idiopathic portal hypertension (IPH).


METHODS
Liver specimens from 29 cases with idiopathic portal hypertension were studied. Histological preparations of the livers were stained with haematoxylin eosin and Masson's trichrome; reticular fibers in the liver tissues were demonstrated. The slides were also stained using some immunohistochemistry methods, and the pathological changes of the livers were analyzed.


RESULTS
The characteristic changes found in these IPH livers were dense portal fibrosis; obliteration, with or without phlebitis, of the branches of the portal vein; dilatation of the sinusoids; atrophy and nodular hyperplasia of liver cells.


CONCLUSIONS
Histopathological changes of the livers in IPH are dense portal fibrosis, portal vein branch obliteration and nodular hyperplasia of liver cells. These are the main features for a histopathological diagnosis of IPH.
Liu
Xia
X
Department of Pathology, China-Japan Friendship Hospital, Beijing, 100029, China.
Wang
Tai-ling
TL
Xiang
Can-hong
CH
Peng
Xiang-xin
XX
Wang
Yue
Y
Chen
Nian
N
Zhang
Min
M
D000293:Adolescent; D000328:Adult; D005260:Female; D005355:Fibrosis / Q000473:pathology; D006801:Humans; D006975:Hypertension, Portal / Q000473:pathology*; D008099:Liver / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D055815:Young Adult