title: Dynamic modeling for shear stress induced ATP release from vascular endothelial cells.
abstract: A dynamic model is proposed for shear stress induced adenosine triphosphate (ATP) release from endothelial cells (ECs). The dynamic behavior of the ATP/ADP concentration at the endothelial surface by viscous shear flow is investigated through simulation studies based on the dynamic ATP release model. The numerical results demonstrate that the ATP/ADP concentration against time at endothelium-fluid interface predicted by the dynamic ATP release model is more consistent with the experimental observations than that predicted by previous static ATP release model.
authors.affiliation: Institute of Mechanobiology and Medical Engineering, Shanghai Jiao Tong University, Mailbox 888, 800 Dongchuan Road, Minhang, Shanghai 200240, China. krqin@sjtu.edu.cn
authors.forename: Kai Rong
authors.initials: KR
authors.lastname: Qin
authors.forename: Cheng
authors.initials: C
authors.lastname: Xiang
authors.forename: Zhe
authors.initials: Z
authors.lastname: Xu
authors.forename: Ling Ling
authors.initials: LL
authors.lastname: Cao
authors.forename: Shuzhi Sam
authors.initials: SS
authors.lastname: Ge
authors.forename: Zong Lai
authors.initials: ZL
authors.lastname: Jiang
mesh_terms: D000244:Adenosine Diphosphate / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism*; D000818:Animals; D002478:Cells, Cultured; D003198:Computer Simulation; D042783:Endothelial Cells / Q000378:metabolism*; D004730:Endothelium, Vascular / Q000166:cytology / Q000378:metabolism; D006801:Humans; D007700:Kinetics; D008955:Models, Cardiovascular; D011673:Pulsatile Flow; D018048:Receptors, Purinergic P2 / Q000378:metabolism; D013314:Stress, Mechanical; D014783:Viscosity
chemical_list: D018048:Receptors, Purinergic P2; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate