title: The total synthesis of psymberin.
abstract: The total synthesis of a new member of the pederin family of natural products, psymberin 1, was accomplished. Using a recently reported novel and efficient PhI(OAc)2 mediated oxidative entry to 2-(N-acylaminal)-substituted tetrahydropyrans as the key step, this total synthesis was executed in a convergent and efficient manner. The longest linear sequence of this synthesis was 22 steps starting from known 6.
authors.affiliation: Department of Chemical Research, Schering-Plough Research Institute, Kenilworth, New Jersey 07033, USA. xianhai.huang@spcorp.com
authors.forename: Xianhai
authors.initials: X
authors.lastname: Huang
authors.forename: Ning
authors.initials: N
authors.lastname: Shao
authors.forename: Anandan
authors.initials: A
authors.lastname: Palani
authors.forename: Robert
authors.initials: R
authors.lastname: Aslanian
authors.forename: Alexei
authors.initials: A
authors.lastname: Buevich
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D003374:Coumarins; D015394:Molecular Structure; D011714:Pyrans / Q000138:chemical synthesis*; D011753:Pyrones / Q000138:chemical synthesis*
chemical_list: D000970:Antineoplastic Agents; D003374:Coumarins; D011714:Pyrans; D011753:Pyrones; C498383:psymberin