Relation between structural and release properties in a polysaccharide gel system.
The potential utility of kappa-carrageenan gels for preparing drug release devices is here shown. Structural properties of kappa-carrageenan gels prepared with different salt composition and containing Ketoprofen sodium salt, as model drug, have been evaluated with static light scattering and rheological measurements. These properties have been correlated with release profiles in vitro at pH 5.5. Release properties from gelled matrices have been compared with those obtained by two commercial products containing the same drug. Results show that: i) in this system it is possible to easily control the gel texture by using different cationic concentration; ii) the kinetics of drug release by kappa-carrageenan gels are dependent on the structural properties of matrices; iii) in the typical interval time used in classical local applications, all gel samples release the loaded drug almost completely, at difference with the commercial products. All these findings can provide useful suggestions for the realization of classical topical release systems.
Mangione
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MR
CNR, Istituto di Biofisica @ Palermo, Via Ugo La Malfa, 153 I-90146 Palermo, Italy.
Giacomazza
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D
Cavallaro
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G
Bulone
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D
Martorana
V
V
San Biagio
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PL
D002351:Carrageenan / Q000737:chemistry / Q000493:pharmacokinetics* / Q000627:therapeutic use; D004337:Drug Carriers / Q000737:chemistry* / Q000493:pharmacokinetics; D005782:Gels / Q000737:chemistry* / Q000493:pharmacokinetics; D007660:Ketoprofen / Q000008:administration & dosage; D007700:Kinetics; D011134:Polysaccharides; D013329:Structure-Activity Relationship
D004337:Drug Carriers; D005782:Gels; D011134:Polysaccharides; D002351:Carrageenan; D007660:Ketoprofen