Are large nonfunctional kidneys risk factors for posttransplantation urinary tract infection in patients with end-stage renal disease due to autosomal dominant polycystic kidney disease?
OBJECTIVE
The objective of this study was to evaluate the effect of bilateral nephrectomy on posttransplantation urinary tract infection (UTI) among patients with end-stage renal disease (ESRD) due to autosomal dominant polycystic kidney disease (ADPKD).


METHODS
In a retrospective case-control design, 62 patients with ESRD with ADPKD were divided into 2 groups: (A) 24 patients who underwent bilateral nephrectomies, and (B) 38 patients in whom bilateral nephrectomies had not been done. Pretransplantation and posttransplantation urine cultures were evaluated for UTI.


RESULTS
Sixty-two patients with ESRD with ADPKD were enrolled in this study. The average age was 42 years (range, 6-60 years). Forty patients (64.5%) were male and 22 (35.5%) were female. The mean duration of hemodialysis was 24 months (range, 2-120 months), which was the same for both groups. Bilateral nephrectomies were done for 24 participants (38.7%). There were 38 patients (61.3%) in group B who did not have the operation. UTI occurred in 23 patients (37.1%): 6 patients (25%) in group A and 17 patients (44.7%) in group B. The incidence of UTI was not statistically different between the 2 groups (P>.05). Furthermore, no relationship was found between age, gender, blood group, and UTI in patients with ADPKD (P>.05).


CONCLUSIONS
According to our study, the presence of large nonfunctional kidneys is not a risk factor for posttransplantation UTI in patients with ADPKD and ESRD.
Salehipour
M
M
Shiraz Transplant Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran. transpln@sums.ac.ir
Jalaeian
H
H
Salahi
H
H
Bahador
A
A
Davari
H R
HR
Nikeghbalian
S
S
Sagheb
M M
MM
Raiss-Jalali
G A
GA
Roozbeh
J
J
Behzadi
S
S
Janghorban
P
P
Sepas
H N
HN
Malek-Hosseini
S A
SA
D000293:Adolescent; D000328:Adult; D002648:Child; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000209:etiology / Q000601:surgery*; D016030:Kidney Transplantation / Q000009:adverse effects* / Q000592:standards; D008297:Male; D008875:Middle Aged; D016891:Polycystic Kidney, Autosomal Dominant / Q000150:complications; D011183:Postoperative Complications / Q000453:epidemiology; D012307:Risk Factors; D014552:Urinary Tract Infections / Q000453:epidemiology*