Antinociceptive effect and acute toxicity of the Hyptis suaveolens leaves aqueous extract on mice.
The aqueous extract of Hyptis suaveolens leaves was studied for their antinociceptive property in chemical and thermal models of nociception in mice. Oral administration of the aqueous extract (100, 200, and 400 mg/kg) dose-dependently reduced the number of writhings induced by acetic acid, decreased the licking activity of the early phase in formalin test and increased the reaction time in hot-plate test. The antinociceptive effect was significantly antagonized by naloxone (3 mg/kg; i.p.). Preliminary acute toxicity study showed that no animal death with doses up to 5 g/kg (p.o.).
Santos
Thiago C
TC
Department of Physiology, Faculty of Pharmaceutical Sciences, Federal University of Sergipe, São Cristovão, Brazil. thc_santos80@hotmail.com
Marques
Maxsuel S
MS
Menezes
Igor A C
IA
Dias
Kellyane S
KS
Silva
Aline B L
AB
Mello
Iderjane C M
IC
Carvalho
Ana C S
AC
Cavalcanti
Sócrates C H
SC
Antoniolli
Angelo R
AR
Marçal
Rosilene M
RM
D019342:Acetic Acid; D000284:Administration, Oral; D000700:Analgesics / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D006358:Hot Temperature; D031331:Hyptis; D008297:Male; D051379:Mice; D010146:Pain / Q000139:chemically induced / Q000517:prevention & control*; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves
D000700:Analgesics; D010936:Plant Extracts; D019342:Acetic Acid