Successful term pregnancy in a patient with Wegener's granulomatosis: case report and literature review.
OBJECTIVE
To present a case of successful term pregnancy in a patient with known Wegener's granulomatosis (WG).


METHODS
Case report.


METHODS
University Hospital, Department of Obstetrics and Gynecology.


METHODS
A 22-year-old primigravida pregnant woman with a history of WG diagnosed 5 years before.


METHODS
The patient was treated with corticosteroids and azathioprine throughout pregnancy, and cyclophosphamide was added postpartum.


METHODS
The disease was in partial remission at the onset of pregnancy, but two relapses occurred, at 33 weeks' gestation and 15 days after delivery. A 3150-g healthy boy was delivered at 37 weeks' gestation.


CONCLUSIONS
Pregnancy in patients with WG requires preconceptional planning, careful clinical management, and vigorous treatment of active disease. There are 36 cases of WG in pregnancy reported in the literature. Owing to this rarity, the management is individualized and the pregnancy outcome is variable. Antenatal management and therapeutic options are discussed and a short review of the literature is presented.
Koukoura
Ourania
O
Department of Obstetrics-Gynecology, University Hospital of Heraklion, Crete, Greece.
Mantas
Nikitas
N
Linardakis
Haralabos
H
Hajiioannou
Jiannis
J
Sifakis
Stavros
S
D000305:Adrenal Cortex Hormones / Q000008:administration & dosage*; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage; D001379:Azathioprine / Q000008:administration & dosage*; D005260:Female; D014890:Granulomatosis with Polyangiitis / Q000150:complications* / Q000188:drug therapy*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis / Q000188:drug therapy*; D011256:Pregnancy Outcome; D047929:Term Birth; D016896:Treatment Outcome
D000305:Adrenal Cortex Hormones; D000893:Anti-Inflammatory Agents; D001379:Azathioprine