HLA DRB1*13 as a risk factor for type 1 autoimmune hepatitis in North American patients.
Our goal was to determine if HLA DRB1*13 is associated with autoimmune hepatitis in North American patients. Two hundred and ten adults with definite type 1 autoimmune hepatitis were typed by DNA-based techniques, and the frequency of HLA DRB1*13 in patients without DRB1*03 and DRB1*04 was compared to that in 396 patients with eight other chronic liver diseases and 102 normal individuals. HLA DRB1*13 occurred more commonly in the autoimmune patients who lacked DRB1*03 and DRB1*04 than normal subjects who were similarly restricted (56% vs. 27%, P = 0.007). The frequency of HLA DRB1*13 was higher in autoimmune patients without DRB1*03 and DRB1*04 than in patients with other chronic liver diseases who were similarly restricted (59% vs. 32%, P = 0.01). Only patients with primary sclerosing cholangitis had a comparable occurrence of HLA DRB1*13. In conclusion, HLA DRB1*13 may be a genetic risk factor for some white North American patients with type 1 autoimmune hepatitis.
Czaja
Albert J
AJ
Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, 200 First Street S.W, Rochester, MN 55905, USA. czaja.albert@mayo.edu
Carpenter
Herschel A
HA
Moore
S Breanndan
SB
D000328:Adult; D002908:Chronic Disease; D005260:Female; D020022:Genetic Predisposition to Disease; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; D006239:Haplotypes; D019693:Hepatitis, Autoimmune / Q000453:epidemiology / Q000235:genetics* / Q000276:immunology; D006525:Hepatitis, Viral, Human / Q000235:genetics / Q000276:immunology; D006801:Humans; D008107:Liver Diseases / Q000235:genetics / Q000276:immunology; D008297:Male; D008875:Middle Aged; D014481:United States; D044465:White People / Q000235:genetics
D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; C506473:HLA-DRB1*13 antigen