title: Clinical significance of microbleeds in subcortical vascular dementia.
abstract: OBJECTIVE
  Despite many studies investigating the association between the ischemic changes and cognitive impairment in subcortical vascular dementia (SVaD), few studies correlated cognitive impairment with microbleeds (MBs) frequently seen in SVaD.
  
  
  METHODS
  Participants consisted of 86 patients with SVaD who fulfilled the criteria proposed by Erkinjuntti et al.
  
  
  RESULTS
  MBs occurred in 73 of 86 (84.9%) patients with SVaD. MBs were most commonly distributed in the cortex, and the cortical MBs were most pronounced in the temporoparietal area. A multiple regression showed that the number of cerebral MB was an independent predictor of cognitive impairment in multiple domains and the severity of dementia even after controlling confounding factors such as age, education, ischemic severity, and number of lacunes.
  
  
  CONCLUSIONS
  These results indicate that cerebral MB is one of the important factors that cause cognitive impairments in SVaD.
authors.forename: Sang Won
authors.initials: SW
authors.lastname: Seo
authors.forename: Byung
authors.initials: B
authors.lastname: Hwa Lee
authors.forename: Eun-Joo
authors.initials: EJ
authors.lastname: Kim
authors.forename: Juhee
authors.initials: J
authors.lastname: Chin
authors.forename: Yoon
authors.initials: Y
authors.lastname: Sun Cho
authors.forename: Uicheul
authors.initials: U
authors.lastname: Yoon
authors.forename: Duk L
authors.initials: DL
authors.lastname: Na
mesh_terms: D000368:Aged; D015140:Dementia, Vascular / Q000150:complications / Q000175:diagnosis*; D005260:Female; D006801:Humans; D020300:Intracranial Hemorrhages / Q000150:complications / Q000175:diagnosis*; D008297:Male; D008833:Microcirculation; D008875:Middle Aged; D012189:Retrospective Studies