Variation in FTO contributes to childhood obesity and severe adult obesity.
We identified a set of SNPs in the first intron of the FTO (fat mass and obesity associated) gene on chromosome 16q12.2 that is consistently strongly associated with early-onset and severe obesity in both adults and children of European ancestry with an experiment-wise P value of 1.67 x 10(-26) in 2,900 affected individuals and 5,100 controls. The at-risk haplotype yields a proportion of attributable risk of 22% for common obesity. We conclude that FTO contributes to human obesity and hence may be a target for subsequent functional analyses.
Dina
Christian
C
CNRS 8090-Institute of Biology, Pasteur Institute, Lille, France. dina@good.ibl.fr
Meyre
David
D
Gallina
Sophie
S
Durand
Emmanuelle
E
Körner
Antje
A
Jacobson
Peter
P
Carlsson
Lena M S
LM
Kiess
Wieland
W
Vatin
Vincent
V
Lecoeur
Cecile
C
Delplanque
Jérome
J
Vaillant
Emmanuel
E
Pattou
François
F
Ruiz
Juan
J
Weill
Jacques
J
Levy-Marchal
Claire
C
Horber
Fritz
F
Potoczna
Natascha
N
Hercberg
Serge
S
Le Stunff
Catherine
C
Bougnères
Pierre
P
Kovacs
Peter
P
Marre
Michel
M
Balkau
Beverley
B
Cauchi
Stéphane
S
Chèvre
Jean-Claude
JC
Froguel
Philippe
P
D050154:Adiposity; D000328:Adult; D017668:Age of Onset; D001823:Body Composition; D015992:Body Mass Index; D016022:Case-Control Studies; D002648:Child; D002885:Chromosomes, Human, Pair 16 / Q000235:genetics*; D015331:Cohort Studies; D005060:Europe; D005260:Female; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation / Q000235:genetics; D006801:Humans; D007438:Introns / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*