Regulation of the actin cytoskeleton by phosphatidylinositol 4-phosphate 5 kinases.
Phosphatidylinositol (4,5)-bisphosphate (PIP(2)) is an important lipid mediator that has multiple regulatory functions. There is now increasing evidence that the phosphatidylinositol 4-phosphate 5 kinases (PIP5Ks), which synthesize PIP(2), are regulated spatially and temporally and that they have isoform-specific functions and regulations. This review will summarize the highlights of recent developments in understanding how the three major PIP5K isoforms regulate the actin cytoskeleton and other important cellular processes.
Mao
Yuntao S
YS
Department of Physiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX, 75390-9040, USA.
Yin
Helen L
HL
D019870:1-Phosphatidylinositol 4-Kinase / Q000378:metabolism* / Q000502:physiology; D000199:Actins / Q000378:metabolism* / Q000502:physiology; D000818:Animals; D003599:Cytoskeleton / Q000378:metabolism* / Q000502:physiology; D006801:Humans; D007527:Isoenzymes; D008840:Microfilament Proteins / Q000378:metabolism; D019269:Phosphatidylinositol 4,5-Diphosphate / Q000502:physiology*
D000199:Actins; D007527:Isoenzymes; D008840:Microfilament Proteins; D019269:Phosphatidylinositol 4,5-Diphosphate; D019870:1-Phosphatidylinositol 4-Kinase