title: Placental ischemia and soluble fms-like tyrosine kinase 1: cause or consequence of preeclampsia?
abstract: Elevated circulating soluble fms-like tyrosine kinase 1 (sFLT-1) is associated with the development of the clinical signs and symptoms of preeclampsia. Placental ischemia has been suggested as one of the etiological factors that mediate increased sFLT-1 production in patients with preeclampsia, but definitive evidence for this hypothesis was lacking. Makris et al. demonstrate that inducing placental ischemia in primates is sufficient to induce sFLT-1 upregulation and the clinical signs and symptoms of preeclampsia.
authors.affiliation: Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA. sananth@bidmc.harvard.edu
authors.forename: S A
authors.initials: SA
authors.lastname: Karumanchi
authors.forename: F H
authors.initials: FH
authors.lastname: Epstein
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D007511:Ischemia / Q000150:complications* / Q000201:enzymology*; D010920:Placenta / Q000098:blood supply*; D011225:Pre-Eclampsia / Q000209:etiology*; D011247:Pregnancy; D040281:Vascular Endothelial Growth Factor Receptor-1 / Q000378:metabolism*
chemical_list: D040281:Vascular Endothelial Growth Factor Receptor-1