Herpes simplex keratitis after intravitreal triamcinolone acetonide.
OBJECTIVE
To report a case of recurrent herpes simplex virus (HSV) epithelial keratitis after intravitreal triamcinolone acetonide injection for the treatment of diabetic macular edema.


METHODS
Case report.


RESULTS
We describe a case of a 59-year-old woman with a history of ocular HSV disease and severe proliferative diabetic retinopathy. She received an intravitreal injection of triamcinolone acetonide for macular edema in the right eye. One week later, she developed foreign body sensation, redness, and photophobia in the same eye. Slit-lamp examination revealed a corneal epithelial dendritic lesion. She was diagnosed with a recurrence of HSV epithelial keratitis and was treated with oral acyclovir 400 mg, 5 times a day, with good resolution of HSV signs and symptoms.


CONCLUSIONS
Intravitreal triamcinolone acetonide injection may result in reactivation of HSV keratitis.
Shtein
Roni M
RM
Department of Ophthalmology and Visual Sciences, University of Michigan, W.K. Kellogg Eye Center, Ann Arbor, MI, USA.
Stahl
Roslyn M
RM
Saxe
Stephen J
SJ
Mian
Shahzad I
SI
D000212:Acyclovir / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use; D003930:Diabetic Retinopathy / Q000188:drug therapy; D005260:Female; D005938:Glucocorticoids / Q000009:adverse effects*; D018259:Herpesvirus 1, Human / Q000502:physiology; D006801:Humans; D007267:Injections; D016849:Keratitis, Herpetic / Q000188:drug therapy / Q000209:etiology*; D008269:Macular Edema / Q000188:drug therapy; D008875:Middle Aged; D012008:Recurrence; D014222:Triamcinolone Acetonide / Q000009:adverse effects*; D014775:Virus Activation / Q000187:drug effects*; D014822:Vitreous Body
D000998:Antiviral Agents; D005938:Glucocorticoids; D014222:Triamcinolone Acetonide; D000212:Acyclovir