Achievement of immune tolerance in a patient with haemophilia B and inhibitory antibodies, complicated by an anaphylactoid reaction.
We describe a young boy with severe haemophilia B who developed inhibitory antibodies and an anaphylactoid reaction to factor IX. Immune tolerance was achieved by desensitisation with escalating doses of factor IX followed by the Malmö regimen.
Curry
N S
NS
Oxford Haemophilia Centre and Thrombosis Unit, Oxford Radcliffe Hospitals, Oxford, UK.
Misbah
S A
SA
Giangrande
P L F
PL
Keeling
D M
DM
D000707:Anaphylaxis / Q000276:immunology*; D000906:Antibodies / Q000276:immunology; D002675:Child, Preschool; D004334:Drug Administration Schedule; D005164:Factor IX / Q000009:adverse effects*; D002836:Hemophilia B / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance; D008297:Male; D016896:Treatment Outcome
D000906:Antibodies; D005164:Factor IX