Anthraquinones from the stem bark of Stereospermum zenkeri with antimicrobial activity.
Two anthraquinones, zenkequinones A and B were isolated from the stem bark of Stereospermum zenkeri together with known sterequinone-F, p-coumaric acid, sitosterol-3-O-beta-D-glucopyranoside and 3beta-hydroxyolean-12-en-28-O-beta-D-glucopyranoside. Their structures were established by spectroscopic methods. The antimicrobial activity of the isolated compounds was evaluated against six multiresistant strains of pathogens. Zenkequinone B showed the best antibacterial activity (MIC 9.50 microg/ml) against gram-negative Pseudomonas aeruginosa.
Lenta
Bruno N
BN
Department of Chemistry, Higher Teachers' Training College, University of Yaoundé 1, Yaoundé, Cameroon.
Weniger
Bernard
B
Antheaume
Cyril
C
Noungoue
Diderot T
DT
Ngouela
Silvère
S
Assob
Jules C N
JC
Vonthron-Sénécheau
Catherine
C
Fokou
Patrice A
PA
Devkota
Krishna P
KP
Tsamo
Etienne
E
Sewald
Norbert
N
D000880:Anthraquinones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D029402:Bignoniaceae / Q000737:chemistry*; D003373:Coumaric Acids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D024301:Plant Bark / Q000737:chemistry; D011422:Propionates; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D012855:Sitosterols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
C522587:3beta-hydroxyolean-12-en-28-O-beta-D-glucopyranoside; D000880:Anthraquinones; D000890:Anti-Infective Agents; D003373:Coumaric Acids; D005960:Glucosides; D011422:Propionates; D012855:Sitosterols; D014315:Triterpenes; C472604:sitosterol-3-O-glucopyranoside; C506378:sterequinone F; C522586:zenkequinone A; C522588:zenkequinone B; C495469:p-coumaric acid