title: Synthesis, Superoxide Dismutase Mimetic and Anticancer Activities of Metal Complexes of 2,2-Dimethylpentanedioic Acid(2dmepdaH(2)) and 3,3-Dimethylpentanedioic acid(3dmepdaH(2)): X-Ray Crystal Structures of [Cu(3dmepda)(bipy)](2). 6H(2)O and [Cu(2dmepda)(bipy)(EtOH)](2). 4EtOH (bipy = 2,2'Bipyridine).
abstract: 2,2-dimethylpentanedioic acid (2dmepdaH(2)) and 3,3-dimethylpentanedioic acid (3dmepdaH(2)) reacted with copper(II) acetate to give [Cu(2dmepda)(H(2)O)(3)](2) (1) and [Cu(3dmepda)(H(2)O)(3)](2) (2). Reaction of (1) and (2) with 1,10-phenanthroline and 2,2'-bipyridine yielded [Cu(2dmepda)(phen)(H(2)O)](2)0.5phen (3), [Cu(2dmepda)(bipy)(H(2)O)](2) (4), [Cu(2dmepda)(bipy)(EtOH)](2). 2EtOH (4A), [Cu(3dmepda)(phen)(H(2)O)](2) (5), and [Cu(3dmepda)(bipy)(H(2)O)](2). (6). The structures of (4A) and (6) each consists of a [Cu(bipy)(dicarboxylate)(solvent)](2) dimer. The superoxide dismutase (SOD) mimetic activity of the novel copper complexes and their manganese analogues was investigated. The dimethyl sulphoxide(DMSO) soluble complexes (1)-(4) and (6) were assessed for their cancer chemotherapeutic potential towards hepatocellular carcinoma and kidney adenocarcinoma cell lines. The 1,10-phenanthroline containing complex [Cu(2dmepda)(phen)(H(2)O)](2)0.5phen (3) was the most potent with activity that compares well to that of cisplatin.
authors.affiliation: Dublin Institute of Technology, Cathal Brugha Street, Dublin 1, Ireland.
authors.forename: Michael
authors.initials: M
authors.lastname: Devereux
authors.forename: Malachy
authors.initials: M
authors.lastname: McCann
authors.forename: Denis
authors.initials: D
authors.lastname: O'shea
authors.forename: Mark
authors.initials: M
authors.lastname: O'connor
authors.forename: Eileen
authors.initials: E
authors.lastname: Kiely
authors.forename: Vickie
authors.initials: V
authors.lastname: McKee
authors.forename: Declan
authors.initials: D
authors.lastname: Naughton
authors.forename: Anna
authors.initials: A
authors.lastname: Fisher
authors.forename: Andrew
authors.initials: A
authors.lastname: Kellett
authors.forename: Maureen
authors.initials: M
authors.lastname: Walsh
authors.forename: Denise
authors.initials: D
authors.lastname: Egan
authors.forename: Carol
authors.initials: C
authors.lastname: Deegan