title: Abyssomicin E, a highly functionalized polycyclic metabolite from Streptomyces species.
abstract: Abyssomicin E (1), a new polycyclic metabolite with a C19 skeleton, was isolated from Streptomyces sp. (HKI0381). Its chemical structure was determined by comprehensive NMR and MS spectroscopic analyses. For the first time in this recently discovered class of compounds, the absolute stereochemistry was directly established by subsequent single-crystal X-ray diffraction study using anomalous dispersion with copper radiation.
authors.affiliation: Leibniz-Institute for Natural Product Research and Infection Biology, Hans-Knöll-Institute, Beutenbergstrasse 11a, D-07745 Jena, Germany.
authors.forename: Xue-Mei
authors.initials: XM
authors.lastname: Niu
authors.forename: Sheng-Hong
authors.initials: SH
authors.lastname: Li
authors.forename: Helmar
authors.initials: H
authors.lastname: Görls
authors.forename: Dieter
authors.initials: D
authors.lastname: Schollmeyer
authors.forename: Matthias
authors.initials: M
authors.lastname: Hilliger
authors.forename: Susanne
authors.initials: S
authors.lastname: Grabley
authors.forename: Isabel
authors.initials: I
authors.lastname: Sattler
mesh_terms: D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism*; D008958:Models, Molecular; D015394:Molecular Structure; D013302:Streptomyces / Q000737:chemistry* / Q000145:classification / Q000378:metabolism*
chemical_list: D019086:Bridged Bicyclo Compounds, Heterocyclic; C522223:abyssomicin E