Cross-linking of elafin/SKALP to elastic fibers in photodamaged skin: too much of a good thing?
Muto et al. report that UVA light induces the expression of elafin, a potent elastase inhibitor, in skin fibroblasts. Elafin binds to elastic fibers by transglutaminase-mediated cross-linking and protects against proteolytic breakdown. Decreased degradation could contribute to accumulation of elastotic material in photodamaged skin. Elastase and its locally produced inhibitors play a role in actinic elastosis.
Schalkwijk
Joost
J
Department of Dermatology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands. J.Schalkwijk@ncmls.ru.nl
D003432:Cross-Linking Reagents / Q000378:metabolism*; D053492:Elafin / Q000378:metabolism*; D004548:Elasticity; D006801:Humans; D015595:Skin Aging / Q000473:pathology*; D012871:Skin Diseases / Q000378:metabolism* / Q000473:pathology*
D003432:Cross-Linking Reagents; D053492:Elafin; C506806:PI3 protein, human