title: Synthesis and cytotoxic evaluation of substituted urea derivatives as inhibitors of human-leukemia K562 cells.
abstract: A series of substituted urea derivatives, compounds 1-14, were synthesized and evaluated for their cytotoxic activities against the human-leukemia K562 cell line. Two structurally simple compounds, 7 and 12, both incorporating a morpholine ring, were found to be highly active, with IC50 values of ca. 0.25 microM.
authors.affiliation: Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, PR China.
authors.forename: Ping
authors.initials: P
authors.lastname: Cao
authors.forename: Xian-Feng
authors.initials: XF
authors.lastname: Huang
authors.forename: Hui
authors.initials: H
authors.lastname: Ding
authors.forename: Hui-Ming
authors.initials: HM
authors.lastname: Ge
authors.forename: Huan-Qiu
authors.initials: HQ
authors.lastname: Li
authors.forename: Ban-Feng
authors.initials: BF
authors.lastname: Ruan
authors.forename: Hai-Liang
authors.initials: HL
authors.lastname: Zhu
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D006801:Humans; D020014:K562 Cells; D007938:Leukemia / Q000473:pathology*; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D014508:Urea / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D014508:Urea