title: Anthraquinones from the stem bark of Stereospermum zenkeri with antimicrobial activity.
abstract: Two anthraquinones, zenkequinones A and B were isolated from the stem bark of Stereospermum zenkeri together with known sterequinone-F, p-coumaric acid, sitosterol-3-O-beta-D-glucopyranoside and 3beta-hydroxyolean-12-en-28-O-beta-D-glucopyranoside. Their structures were established by spectroscopic methods. The antimicrobial activity of the isolated compounds was evaluated against six multiresistant strains of pathogens. Zenkequinone B showed the best antibacterial activity (MIC 9.50 microg/ml) against gram-negative Pseudomonas aeruginosa.
authors.affiliation: Department of Chemistry, Higher Teachers' Training College, University of Yaoundé 1, Yaoundé, Cameroon.
authors.forename: Bruno N
authors.initials: BN
authors.lastname: Lenta
authors.forename: Bernard
authors.initials: B
authors.lastname: Weniger
authors.forename: Cyril
authors.initials: C
authors.lastname: Antheaume
authors.forename: Diderot T
authors.initials: DT
authors.lastname: Noungoue
authors.forename: Silvère
authors.initials: S
authors.lastname: Ngouela
authors.forename: Jules C N
authors.initials: JC
authors.lastname: Assob
authors.forename: Catherine
authors.initials: C
authors.lastname: Vonthron-Sénécheau
authors.forename: Patrice A
authors.initials: PA
authors.lastname: Fokou
authors.forename: Krishna P
authors.initials: KP
authors.lastname: Devkota
authors.forename: Etienne
authors.initials: E
authors.lastname: Tsamo
authors.forename: Norbert
authors.initials: N
authors.lastname: Sewald
mesh_terms: D000880:Anthraquinones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D029402:Bignoniaceae / Q000737:chemistry*; D003373:Coumaric Acids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D024301:Plant Bark / Q000737:chemistry; D011422:Propionates; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D012855:Sitosterols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: C522587:3beta-hydroxyolean-12-en-28-O-beta-D-glucopyranoside; D000880:Anthraquinones; D000890:Anti-Infective Agents; D003373:Coumaric Acids; D005960:Glucosides; D011422:Propionates; D012855:Sitosterols; D014315:Triterpenes; C472604:sitosterol-3-O-glucopyranoside; C506378:sterequinone F; C522586:zenkequinone A; C522588:zenkequinone B; C495469:p-coumaric acid