title: Role of beta-chemokines in mast cell activation and type I hypersensitivity reactions in the conjunctiva: in vivo and in vitro studies.
abstract: Chemokines have a clearly defined role in mobilizing the recruitment of leukocytes to both healthy and inflamed tissues. This review details work from our and other laboratories, indicating that beta-chemokines may play important roles (i) in driving the terminal differentiation of mast cell precursors in mucosal tissues and (ii) in providing priming or costimulatory signals required for mast cell activation, leading to an antigen-driven inflammatory response. These data stem from in vivo, ex vivo, and in vitro studies. Data are also presented that suggest that Fc epsilon RI:chemokine receptor cross talk may involve spatiotemporal dynamics that may control the strength and nature of the complex activating signals controlling mast cell effector function.
authors.affiliation: Emory University School of Medicine, Emory Eye Center, Atlanta, GA, USA.
authors.forename: Frederick
authors.initials: F
authors.lastname: Beer
authors.forename: Chuan-Hui
authors.initials: CH
authors.lastname: Kuo
authors.forename: Kei
authors.initials: K
authors.lastname: Morohoshi
authors.forename: James
authors.initials: J
authors.lastname: Goodliffe
authors.forename: Peter
authors.initials: P
authors.lastname: Munro
authors.forename: Cho Cho
authors.initials: CC
authors.lastname: Aye
authors.forename: Maria
authors.initials: M
authors.lastname: Dawson
authors.forename: Ricardo M
authors.initials: RM
authors.lastname: Richardson
authors.forename: Limei H
authors.initials: LH
authors.lastname: Jones
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Ikeda
authors.forename: Takao
authors.initials: T
authors.lastname: Nakamura
authors.forename: Masako
authors.initials: M
authors.lastname: Toda
authors.forename: Tom
authors.initials: T
authors.lastname: Flynn
authors.forename: Masaharu
authors.initials: M
authors.lastname: Ohbayashi
authors.forename: Dai
authors.initials: D
authors.lastname: Miyazaki
authors.forename: Santa Jeremy
authors.initials: SJ
authors.lastname: Ono
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000737:chemistry; D019742:Chemokines, CC / Q000032:analysis / Q000235:genetics / Q000378:metabolism*; D003228:Conjunctiva / Q000276:immunology*; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology*; D008407:Mast Cells / Q000276:immunology* / Q000648:ultrastructure; D017455:Receptors, IgE / Q000276:immunology*
chemical_list: D019742:Chemokines, CC; D017455:Receptors, IgE