title: Lipidic profile among rats submitted to total splenectomy isolated or combined with splenic autotransplant.
abstract: OBJECTIVE
  To evaluate the alterations on plasmatic lipids levels among rats submitted to total splenectomy isolated or combined with splenic autotransplant receiving standard chow during the postoperative period.
  
  
  METHODS
  Thirty Wistar rats were divided into three groups: control (C)-- sham-operated, total splenectomy--isolated (TS) or combined with splenic autotransplantation (SA). Since the postoperative period, all animals received standard rat chow manipulated in accordance to the American Institute of Nutrition Rodents Diets (1993). The plasmatic levels of total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), very-low-density lipoprotein (VLDL), and glucose (GLUC) were analyzed before the surgical procedure and after 6 and 12 weeks.
  
  
  RESULTS
  All the animals presented significant increase of TG and VLDL levels. In relation to the other parameters there was no difference among the weeks 0 and 12 in the animals of group C. In TS group significant increase was observed in TC and GLUC levels during the experiment. In SA group TC, HDL, and GLUC levels remained unaffected while HDL levels increased.
  
  
  CONCLUSIONS
  Our findings suggest that isolated total splenectomy alters lipids metabolism in rats fed with standard chow and splenic autotransplantation is effective in restoring its control.
authors.affiliation: Laboratory of Experimental Surgery, Rio de Janeiro State University, 22730-290 Rio de Janeiro, RJ, Brazil. fsimoesnut@hotmail.com
authors.forename: Fernanda Correia
authors.initials: FC
authors.lastname: Simões
authors.forename: Ruy Garcia
authors.initials: RG
authors.lastname: Marques
authors.forename: Cristina Fajardo
authors.initials: CF
authors.lastname: Diestel
authors.forename: Carlos Eduardo Rodrigues
authors.initials: CE
authors.lastname: Caetano
authors.forename: Ana Paula Gonçalves
authors.initials: AP
authors.lastname: Dinis
authors.forename: Nara Limeira
authors.initials: NL
authors.lastname: Horst
authors.forename: José Firmino
authors.initials: JF
authors.lastname: Nogueira Neto
authors.forename: Margareth Crisóstomo
authors.initials: MC
authors.lastname: Portela
mesh_terms: D000821:Animal Feed; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D002784:Cholesterol / Q000097:blood*; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood; D008297:Male; D011184:Postoperative Period; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013154:Spleen / Q000637:transplantation*; D013156:Splenectomy / Q000379:methods*; D014182:Transplantation, Autologous; D014280:Triglycerides / Q000097:blood
chemical_list: D001786:Blood Glucose; D008055:Lipids; D008074:Lipoproteins; D014280:Triglycerides; D002784:Cholesterol