[Morphometric characteristic of the subepithelial connective tissue of the rabbit gingiva under the experimental gingivitis on the background of hypercholesterinemia].
The morphologic substrate of the gingival mucosa membrane during the increase of the proatherogenic lipids concentration and the damage the gingiva under the influence of the atherogenic diet was studied in experiment. By the planimetric method the middle indices of the number of capillaries, arterioles and venules and as well the quantities of immunocompetent cells (macrophages and lymphocytes) in the gingival subepithelial connective tissue were defined. The experiments were carried out on rabbits (race "Shinshila"). Animals were on atherogenic ration (cholesterol 0,3 g/kg with vegetables). The experimental gingivitis was modeled by ligation of a silk ligature around the dental neck of the tree superior basal teeth after peeling the gingiva. It was established that under the gingivitis developing against the background of hypercholesterinemia in the subepithelial layer of the gingival mucosa the degree of the vascularisation distinctly diminished, owing to the decrease the number of arteriols and partly capillaries and transformation their walls--the thin-walled capillaries with obliterated, deformated lumen appeared. Endotheliocites with changed structure, ordinary pycnosis of nuclei which creates the necessary prereqvisites for the disturbance of trophicity and progression of the inflammatory process.
Maklakelidze
N N
NN
Gogiashvili
L E
LE
Gorgoshidze
G G
GG
Dgebuadze
m A
mA
Tsagareli
Z G
ZG
D000818:Animals; D002682:Chinchilla; D003238:Connective Tissue / Q000276:immunology / Q000473:pathology*; D016207:Cytokines / Q000276:immunology; D005891:Gingivitis / Q000453:epidemiology* / Q000276:immunology / Q000473:pathology*; D006937:Hypercholesterolemia / Q000453:epidemiology*; D010518:Periodontitis / Q000453:epidemiology / Q000276:immunology
D016207:Cytokines