Effect of epsilon-aminocaproylamino acids on fibrin formation.
Effect of three epsilon-aminocaproylamino acids with significant antifibrinolytic activity on polymerization of fibrin monomer, clot retraction, fibrin structure, prothrombin consumption and thrombin activity was examined. epsilon-Aminocaproyl-L-norleucine and epsilon-aminocaproyl-L-leucine were weak inhibitors of thrombin activity and epsilon-aminocaproyl-L-norleucine slightly inhibited polymerization of fibrin monomers.
Bruzgo
Irena
I
Department of Organic Chemistry, Medical University of Białystok, Kilińskiego Str. 1, 15-089 Białystok, Poland.
Midura-Nowaczek
Krystyna
K
Bruzgo
Magdalena
M
Kaczyńska
Joanna
J
Roszkowska-Jakimiec
Wiesława
W
D015119:Aminocaproic Acid / Q000737:chemistry* / Q000494:pharmacology; D000933:Antifibrinolytic Agents / Q000737:chemistry / Q000494:pharmacology; D001777:Blood Coagulation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005337:Fibrin / Q000737:chemistry*; D005342:Fibrinolysis / Q000187:drug effects; D006801:Humans; D014914:Whole Blood Coagulation Time
D000933:Antifibrinolytic Agents; D005337:Fibrin; D015119:Aminocaproic Acid