title: [Cyclosporine-induced gingival hyperplasia: report of one case].
abstract: Gingival enlargement can be an adverse effect of cyclosporine A and nifedipine use. It has a high relapse rate if the drugs are not discontinued. There is a genetic predisposition to the development of this condition and dental biofilm can also play a role. We report a 64 years old male who received a renal allograft and was treated with cyclosporine and nifedipine. He required six surgical interventions for generalized gingival enlargement. After the sixth relapse, the patient was subjected to a periodontal treatment to eliminate the dental biofilm, which decreased the rate of recurrence of gingival enlargement.
authors.affiliation: Cátedra de Periodoncia, Universidad de Valparaíso, Servicio Odontológico Hospital Dr. Gustavo Fricke, Viña del Mar.
authors.forename: Carlos
authors.initials: C
authors.lastname: Bahamondes
authors.forename: Jorge
authors.initials: J
authors.lastname: Godoy
mesh_terms: D018441:Biofilms / Q000187:drug effects* / Q000254:growth & development; D002121:Calcium Channel Blockers / Q000009:adverse effects*; D016572:Cyclosporine / Q000009:adverse effects*; D005881:Gingiva / Q000648:ultrastructure; D005885:Gingival Hyperplasia / Q000139:chemically induced*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000009:adverse effects*; D012008:Recurrence; D012720:Severity of Illness Index
chemical_list: D002121:Calcium Channel Blockers; D007166:Immunosuppressive Agents; D016572:Cyclosporine; D009543:Nifedipine