title: Dose-dependent constipation with higher doses of quetiapine: a case series.
abstract: Quetiapine is a dopamine D2 and serotonin 5-HT2 antagonist with antipsychotic and mood-stabilizing properties. Recent studies suggest that higher doses of quetiapine combine superior therapeutic efficacy with good tolerability. We present five patients, in whom treatment with higher doses of quetiapine was associated with constipation. Our observations raise the question of dose-dependent constipation under treatment with quetiapine.
authors.affiliation: Department of Psychiatry, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. traedler@uke.uni-hamburg.de
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Raedler
authors.forename: Jens
authors.initials: J
authors.lastname: Reimer
authors.forename: Klaus
authors.initials: K
authors.lastname: Wiedemann
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000008:administration & dosage* / Q000009:adverse effects*; D003248:Constipation / Q000139:chemically induced*; D003863:Depression / Q000188:drug therapy; D003987:Dibenzothiazepines / Q000008:administration & dosage* / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011618:Psychotic Disorders / Q000188:drug therapy; D000069348:Quetiapine Fumarate; D012559:Schizophrenia / Q000188:drug therapy
chemical_list: D014150:Antipsychotic Agents; D003987:Dibenzothiazepines; D000069348:Quetiapine Fumarate