title: Nagelamide J, a novel dimeric bromopyrrole alkaloid from a sponge Agelas species.
abstract: A novel dimeric bromopyrrole alkaloid, nagelamide J (1), with antimicrobial activity has been isolated from an Okinawan marine sponge Agelas species, and the structure and stereochemistry were elucidated from spectroscopic data. Nagelamide J (1) is the first bromopyrrole alkaloid possessing a cyclopentane ring fused to an amino imidazole ring.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Araki
authors.forename: Masashi
authors.initials: M
authors.lastname: Tsuda
authors.forename: Takaaki
authors.initials: T
authors.lastname: Kubota
authors.forename: Yuzuru
authors.initials: Y
authors.lastname: Mikami
authors.forename: Jane
authors.initials: J
authors.lastname: Fromont
authors.forename: Jun'ichi
authors.initials: J
authors.lastname: Kobayashi
mesh_terms: D047230:Agelas / Q000737:chemistry*; D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D000818:Animals; D003455:Cryptococcus neoformans / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D015394:Molecular Structure; D011758:Pyrroles / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D012680:Sensitivity and Specificity; D013045:Species Specificity; D013211:Staphylococcus aureus / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D000470:Alkaloids; D011758:Pyrroles; C521922:nagelamide J