Changes in central dopaminergic systems with the expression of Shh or GDNF in mice perinatally exposed to bisphenol-A.
In the previous study, we reported that exposure to bisphenol-A induced the potentiation of dopamine receptor functions in the mouse limbic area, resulting in supersensitivity to methamphetamine-induced pharmacological actions. The present study was undertaken to investigate whether prenatal exposure to bisphenol-A could produce morphological change in dopaminergic neuron and the pattern of expression of genes regulating the dopaminergic neuron development. Here we found that prenatal and neonatal exposures to bisphenol-A increased the tyrosine hydroxylase- and dopamine transporter-like immunoreactivities in the adult mouse limbic area. The present molecular biological study shows that chronic bisphenol-A treatment produced a significant decrease in the dopaminergic neuron development factors, sonic hedgehog and glial cell line-derived neurotrophic factor, which were also decreased by prenatal exposure to bisphenol-A. These results suggest that chronic exposure to bisphenol-A could disrupt the dopaminergic neurotransmission in the process of dopaminergic neuron development.
Miyagawa
Kazuya
K
Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences.
Narita
Minoru
M
Narita
Michiko
M
Niikura
Keiichi
K
Akama
Hisahiko
H
Tsurukawa
Yuri
Y
Suzuki
Tsutomu
T
D000818:Animals; D001559:Benzhydryl Compounds; D001921:Brain / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D015536:Down-Regulation; D005260:Female; D051100:Glial Cell Line-Derived Neurotrophic Factor / Q000096:biosynthesis*; D053823:Hedgehog Proteins / Q000096:biosynthesis*; D008297:Male; D018811:Maternal Exposure; D051379:Mice; D008810:Mice, Inbred C57BL; D010636:Phenols / Q000494:pharmacology*; D011247:Pregnancy; D050637:Receptors, Dopamine D3 / Q000096:biosynthesis; D020133:Reverse Transcriptase Polymerase Chain Reaction; D000098826:Bisphenol A Compounds
D001559:Benzhydryl Compounds; D004298:Dopamine; D051100:Glial Cell Line-Derived Neurotrophic Factor; D053823:Hedgehog Proteins; D010636:Phenols; D050637:Receptors, Dopamine D3; C509239:SHH protein, human; C006780:bisphenol A; D000098826:Bisphenol A Compounds