Beneficial effects of the extract from Corydalis yanhusuo in rats with heart failure following myocardial infarction.
As indicated in ancient Chinese medical books, Corydalis yanhusuo has therapeutic effects on cardiovascular diseases. The analgesic effect of this plant has been fully elucidated, and l-tetrahydropalmatine has been shown to be the main active principle. The aim of this investigation was to evaluate its protective effects in a rat heart failure model. Rats were subjected to coronary artery ligation, and orally administered with ethanolic extract of Corydalis yanhusuo 50, 100, or 200 mg kg(-1) daily, from the 7th day after surgery. We measured cardiac function, plasma atrial natriuretic peptide (ANP), relative heart and lung weights, infarct size and ventricular dilatation after treatment for 8 weeks. Administration with Corydalis yanhusuo led to a significant reduction in infarct size and improvement in cardiac function as demonstrated by lower left ventricular end diastolic pressure (LVEDP) and elevated +/-dp/dt(max). We also found that Corydalis yanhusuo significantly reduced left ventricular (LV)/body weight ratio, lung/body weight ratio and significantly inhibited neurohormonal activation. Taken together, this study indicated that Corydalis yanhusuo exerted salutary effects on heart failure induced by myocardial infarction in rats.
Wu
Limao
L
Department of Pharmacology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, P R China. wulimao@yahoo.com.cn
Ling
Haiyun
H
Li
Lianda
L
Jiang
Lianxiu
L
He
Minle
M
D000818:Animals; D009320:Atrial Natriuretic Factor / Q000097:blood; D001794:Blood Pressure / Q000187:drug effects; D002303:Cardiac Output, Low / Q000188:drug therapy* / Q000209:etiology; D002316:Cardiotonic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D003331:Coronary Vessels; D031311:Corydalis; D004108:Dilatation, Pathologic / Q000188:drug therapy; D004305:Dose-Response Relationship, Drug; D006321:Heart / Q000187:drug effects; D006334:Heart Function Tests; D008026:Ligation; D008168:Lung / Q000187:drug effects; D008297:Male; D009203:Myocardial Infarction / Q000150:complications*; D009929:Organ Size / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D010946:Plants, Medicinal; D051381:Rats; D017207:Rats, Sprague-Dawley; D027343:Rhizome
D002316:Cardiotonic Agents; D010936:Plant Extracts; D009320:Atrial Natriuretic Factor