title: Neurological complications following endoluminal repair of thoracic aortic disease.
abstract: Open surgery for thoracic aortic disease is associated with significant morbidity and the reported rates for paraplegia and stroke are 3%-19% and 6%-11%, respectively. Spinal cord ischemia and stroke have also been reported following endoluminal repair. This study reviews the incidence of paraplegia and stroke in a series of 186 patients treated with thoracic stent grafts. From July 1997 to September 2006, 186 patients (125 men) underwent endoluminal repair of thoracic aortic pathology. Mean age was 71 years (range, 17-90 years). One hundred twenty-eight patients were treated electively and 58 patients had urgent procedures. Anesthesia was epidural in 131, general in 50, and local in 5 patients. Seven patients developed paraplegia (3.8%; two urgent and five elective). All occurred in-hospital apart from one associated with severe hypotension after a myocardial infarction at 3 weeks. Four of these recovered with cerebrospinal fluid (CSF) drainage. One patient with paraplegia died and two had permanent neurological deficit. The rate of permanent paraplegia and death was 1.6%. There were seven strokes (3.8%; four urgent and three elective). Three patients made a complete recovery, one had permanent expressive dysphasia, and three died. The rate of permanent stroke and death was 2.1%. Endoluminal treatment of thoracic aortic disease is an attractive alternative to open surgery; however, there is still a risk of paraplegia and stroke. Permanent neurological deficits and death occurred in 3.7% of the patients in this series. We conclude that prompt recognition of paraplegia and immediate insertion of a CSF drain can be an effective way of recovering spinal cord function and improving the prognosis.
authors.affiliation: Department of Vascular Surgery, Guy's and St. Thomas' Foundation Hospital NHS Trust, Lambeth Palace Road, London, UK.
authors.forename: J P
authors.initials: JP
authors.lastname: Morales
authors.forename: P R
authors.initials: PR
authors.lastname: Taylor
authors.forename: R E
authors.initials: RE
authors.lastname: Bell
authors.forename: Y C
authors.initials: YC
authors.lastname: Chan
authors.forename: T
authors.initials: T
authors.lastname: Sabharwal
authors.forename: T W G
authors.initials: TW
authors.lastname: Carrell
authors.forename: J F
authors.initials: JF
authors.lastname: Reidy
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001013:Aorta, Thoracic / Q000601:surgery*; D001018:Aortic Diseases / Q000453:epidemiology / Q000601:surgery*; D001807:Blood Vessel Prosthesis; D019917:Blood Vessel Prosthesis Implantation / Q000009:adverse effects* / Q000295:instrumentation; D004322:Drainage / Q000379:methods; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D010264:Paraplegia / Q000209:etiology* / Q000401:mortality / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D020127:Recovery of Function; D020760:Spinal Cord Ischemia / Q000209:etiology* / Q000401:mortality / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D015607:Stents; D020521:Stroke / Q000209:etiology* / Q000401:mortality / Q000473:pathology / Q000503:physiopathology; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome