Interdomain loop mutation Asp190Cys of the tetracycline efflux transporter TetA(B) decreases affinity for substrate.
Sapunaric
Frédéric M
FM
Levy
Stuart B
SB
D017920:Antiporters / Q000235:genetics*; D001426:Bacterial Proteins / Q000235:genetics*; D001693:Biological Transport, Active; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics / Q000378:metabolism*; D009154:Mutation; D013379:Substrate Specificity; D013752:Tetracycline / Q000378:metabolism*; D013753:Tetracycline Resistance / Q000235:genetics*; D014316:Tritium / Q000378:metabolism
D017920:Antiporters; D001426:Bacterial Proteins; C079051:tetA protein, Bacteria; D014316:Tritium; D013752:Tetracycline