Novel synthesis of alpha-PNA monomers by U-4CR.
A novel synthesis of alpha-PNA monomers was carried out by U-4CR, followed by photochemical cleavage of the 2-nitrobenzyl group and selective hydrolysis in the presence of 10% HCl in THF. Three of four functional components in the U-4CR were specially protected: cyclohexenyl isocyanide, Boc for protecting the amino group of glycine, and 2-nitrobenzyl group as a photocage (photoremovable protecting group) for ammonia. The amino group of aldehyde-containing adenine is too weak to interfere with the U-4CR, so that it is not necessary to be protected.
Huang
P-C
PC
Department of Chemistry, National Cheng Kung University, Tainan, Taiwan, ROC.
Hsu
G-J
GJ
Zhuang
B-R
BR
Sung
K
K
D015394:Molecular Structure; D020135:Peptide Nucleic Acids / Q000138:chemical synthesis* / Q000737:chemistry
D020135:Peptide Nucleic Acids