title: Prospective randomized trial of empiric therapy with trimethoprim-sulfamethoxazole or doxycycline for outpatient skin and soft tissue infections in an area of high prevalence of methicillin-resistant Staphylococcus aureus.
abstract: To evaluate empirical therapy with trimethoprim-sulfamethoxazole or doxycycline for outpatient skin and soft tissue infections in an area of high prevalence of methicillin-resistant Staphylococcus aureus, a randomized, prospective, open-label investigation was performed. The overall clinical failure rate was 9%, with all failures occurring in the trimethoprim-sulfamethoxazole group. However, there was no significant difference between the clinical failure rate of empirical trimethoprim-sulfamethoxazole therapy and that of doxycycline therapy.
authors.affiliation: University of Texas Southwestern Medical Center, Dallas, Texas 75390-9063, USA.
authors.forename: Mary Jo
authors.initials: MJ
authors.lastname: Cenizal
authors.forename: Daniel
authors.initials: D
authors.lastname: Skiest
authors.forename: Samuel
authors.initials: S
authors.lastname: Luber
authors.forename: Roger
authors.initials: R
authors.lastname: Bedimo
authors.forename: Pat
authors.initials: P
authors.lastname: Davis
authors.forename: Patrick
authors.initials: P
authors.lastname: Fox
authors.forename: Kathleen
authors.initials: K
authors.lastname: Delaney
authors.forename: R Doug
authors.initials: RD
authors.lastname: Hardy
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002481:Cellulitis / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology*; D004318:Doxycycline / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D036262:Empirical Research; D005500:Follow-Up Studies; D006801:Humans; D016106:Methicillin Resistance / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D010045:Outpatients; D015995:Prevalence; D011446:Prospective Studies; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000145:classification* / Q000187:drug effects / Q000235:genetics; D013420:Sulfamethoxazole / Q000627:therapeutic use; D013997:Time Factors; D016896:Treatment Outcome; D014295:Trimethoprim / Q000627:therapeutic use
chemical_list: D014295:Trimethoprim; D013420:Sulfamethoxazole; D004318:Doxycycline