Beta-elimination and peptide bond hydrolysis: two distinct mechanisms of human IgG1 hinge fragmentation upon storage.
Cohen
Steven L
SL
Merck Research Laboratories, West Point, Pennsylvania 19486, USA.
Price
Colleen
C
Vlasak
Josef
J
D000595:Amino Acid Sequence; D006801:Humans; D006868:Hydrolysis; D007128:Immunoglobulin Fragments / Q000737:chemistry / Q000378:metabolism; D007074:Immunoglobulin G / Q000737:chemistry* / Q000378:metabolism*; D010455:Peptides / Q000737:chemistry* / Q000378:metabolism*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
D007128:Immunoglobulin Fragments; D007074:Immunoglobulin G; D010455:Peptides