Factor XIII gene V34L mutation in the Lebanese population: another unique feature in this community?
We studied the distribution of the Factor XIII gene V34L polymorphism in a sample of healthy Lebanese individuals to assess its prevalence and compare it with other populations. Factor XIII genotypes were determined using the Cardiovascular Disease (CVD) StripAssay (ViennaLab, Austria), which is based on a Polymerase Chain Reaction-Reverse hybridization technique. DNA from 205 unrelated healthy donors from our HLA database was used. The prevalence of Wild type, heterozygous, and homozygous genotypes was found to be 74.2%, 22.4%, and 3.4% respectively. The sampled Lebanese population showed that the prevalence of V34L carriers (25.8%) was lower than Caucasians in general (44.3%) and, interestingly, with a low allele frequency of 0.14 similar to that in Blacks and South Asians. This first report from Lebanon sheds light on an additional unique genetic feature of this population and will prospectively serve as a baseline statistical data for future investigations of the prevalence of Factor XIII V34L mutation in association with various clinical entities notably cardiovascular diseases.
Mahfouz
Rami A R
RA
American University of Beirut Medical Center, Department of Pathology, Laboratory Of Medicine, Riad El Sol, Beirut, Lebanon. rm11@aub.edu.lb
Sabbagh
Amira S
AS
Shammaa
Dina M R
DM
Otrock
Zaher K
ZK
Zaatari
Ghazi S
GS
Taher
Ali T
AT
D005176:Factor XIII / Q000235:genetics*; D005260:Female; D005838:Genotype; D006262:Health; D006801:Humans; D007861:Lebanon; D007930:Leucine / Q000235:genetics; D008297:Male; D009154:Mutation / Q000235:genetics; D014633:Valine / Q000235:genetics
D005176:Factor XIII; D007930:Leucine; D014633:Valine