Fertility preservation with treatment of immature teratoma of the ovary.
Fertility preservation for a patient with advanced immature teratoma of the ovary is reported. The patient, a 29-year-old woman, delivered a healthy baby after having had ovarian immature teratoma, grade 3, uncertain stage, at 13 years of age. She was initially treated with unilateral salpingo-oophorectomy and a contralateral wedge resection for tumor invasion, followed by a 6-course cisplatin+vinblastine+bleomycin regimen, a second operation, and an additional 6-course etoposide and cisplatin regimen with complete remission. The patient delivered a healthy baby 16 years after the initial treatment. Based on this successful case, intensive fertility-preserving surgery followed by chemotherapy, even in advanced-stage immature teratomas of the ovary, may be effective in preserving the reproductive function of women with malignant immature teratomas of the ovary.
Chen
Chia-Hui
CH
Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, and National Yang-Ming University School of Medicine, Taipei, Taiwan, ROC.
Yang
Ming-Jie
MJ
Cheng
Ming-Huei
MH
Yen
Ming-Shyen
MS
Lai
Chiung-Ru
CR
Wang
Peng-Hui
PH
D000328:Adult; D005260:Female; D005298:Fertility; D006801:Humans; D010051:Ovarian Neoplasms / Q000503:physiopathology / Q000628:therapy*; D013724:Teratoma / Q000503:physiopathology / Q000628:therapy*