DBH -1021C-->T does not modify risk or age at onset in Parkinson's disease.
DBH is a candidate gene in Parkinson's disease (PD) and contains a putative functional polymorphism (-1021C-->T) that has been reported to modify PD susceptibility. We examined -1021C-->T in a sample of 1,244 PD patients and 1,186 unrelated control subjects. There was no significant difference in allele (p = 0.14) or genotype (p = 0.26) frequencies between the two groups. A similar result was obtained after pooling our data with those previously published. Furthermore, we found no evidence for an effect of genotype on age at onset among patients. Our findings argue against DBH -1021C-->T as a risk factor or age at onset modifier in PD.
Chun
Lani S
LS
Department of Neurology, University of Washington School of Medicine, Seattle, WA 98108, USA.
Samii
Ali
A
Hutter
Carolyn M
CM
Griffith
Alida
A
Roberts
John W
JW
Leis
Berta C
BC
Mosley
Anthony D
AD
Wander
P Luke
PL
Edwards
Karen L
KL
Payami
Haydeh
H
Zabetian
Cyrus P
CP
D017668:Age of Onset; D000368:Aged; D000483:Alleles; D016009:Chi-Square Distribution; D004299:Dopamine beta-Hydroxylase / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000453:epidemiology / Q000235:genetics* / Q000503:physiopathology; D011110:Polymorphism, Genetic; D012306:Risk
D004299:Dopamine beta-Hydroxylase