title: [The expression of peroxiredoxin II in hepatocellular carcinoma and its significance].
abstract: OBJECTIVE
  To evaluate the mRNA and protein expressions of peroxiredoxin II (PrxII) in hepatocellular carcinoma (HCC) and their significance.
  
  
  METHODS
  HCC was induced by aflatoxin B1 (AFB1) in 6 tree shrews (Tupaia belangeri chinensis). The expression levels of PrxII mRNA and protein were detected by reverse transcriptase polymerase chain reaction (RT-PCR) and Western blot on HCC tissues and on their surrounding liver tissues (para-HCC). Biopsied liver tissues were taken before the HCC induction (pre-HCC) from the same animals and from a group of blank controlled animals that served as controls. Liver biopsy specimens from 18 cases of human HCC and from 17 healthy human volunteers were studied using the same methods.
  
  
  RESULTS
  The mRNA and protein expressions of PrxII in tree shrew HCC tissues were significantly higher than those in para-HCC and pre-HCC tissues, and also higher than those in the liver tissues from the control animals (all P < 0.05). The expression levels of PrxII mRNA and protein in human HCC tissues were also significantly higher than those in their para-HCC tissues and in the human normal liver tissues (P < 0.05).
  
  
  CONCLUSIONS
  PrxII might play an important role in hepatocarcinogenesis and might be used as a molecular target for HCC prevention and treatment.
authors.affiliation: Affiliated Tumor Hospital of Guangxi Medical University, Nanning 530021, China.
authors.forename: Hai-ying
authors.initials: HY
authors.lastname: Yue
authors.forename: Ji
authors.initials: J
authors.lastname: Cao
authors.forename: Ji-feng
authors.initials: JF
authors.lastname: Cui
authors.forename: Zhi
authors.initials: Z
authors.lastname: Dai
authors.forename: Jian-jia
authors.initials: JJ
authors.lastname: Su
authors.forename: Xiao-xian
authors.initials: XX
authors.lastname: Duan
authors.forename: Chun
authors.initials: C
authors.lastname: Yang
authors.forename: Hui-fen
authors.initials: HF
authors.lastname: Yue
authors.forename: Yuan
authors.initials: Y
authors.lastname: Li
authors.forename: Yin-kun
authors.initials: YK
authors.lastname: Liu
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D008099:Liver / Q000378:metabolism* / Q000473:pathology; D008113:Liver Neoplasms / Q000378:metabolism* / Q000473:pathology; D008114:Liver Neoplasms, Experimental / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D054464:Peroxiredoxins / Q000235:genetics*; D014418:Tupaiidae
chemical_list: D054464:Peroxiredoxins