Association between genetic polymorphisms in the human interleukin-7 receptor alpha-chain and inhalation allergy.
Thymic stromal-derived lymphopoietin (TSLP) and interleukin-7 share a common receptor chain, IL-7Ralpha. IL-7 is involved in T-cell homeostasis, and TSLP induces production of pro-allergic cytokines. The gene encoding the IL-7Ralpha chain is polymorphic, and investigation of inhalation allergic patients compared with controls showed significant association with two alleles at position +1237 and +2087.
Shamim
Z
Z
Tissue Typing Laboratory, Department of Clinical Immunology, Rigshospitalet, Denmark. zaiba_shamim@hotmail.com
Müller
K
K
Svejgaard
A
A
Poulsen
L K
LK
Bodtger
U
U
Ryder
L P
LP
D000328:Adult; D016022:Case-Control Studies; D003718:Denmark / Q000453:epidemiology; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D020395:Receptors, Interleukin-7 / Q000235:genetics*; D012130:Respiratory Hypersensitivity / Q000453:epidemiology / Q000235:genetics*
D020395:Receptors, Interleukin-7; C415350:interleukin-7 receptor, alpha chain