title: Locked-in syndrome due to invasive fungal rhinosinusitis in an immunosuppressed patient.
abstract: BACKGROUND
  The locked-in syndrome is typically caused by basilar artery thrombosis, resulting in ventral pontine infarction. Infectious basilar arteritis is a rare alternative etiology.
  
  
  METHODS
  We present a 24-year-old female with a prodrome of facial pain without fever or meningismus, who developed a locked-in syndrome due to an invasive fungal infection after bone marrow transplantation. The clinical course and neuroimaging demonstrating sinusitis with adjacent pontine infarction but without basilar artery thrombosis are presented. The infectious differential diagnosis and management of invasive fungal infection are discussed.
  
  
  CONCLUSIONS
  Facial pain without fever or meningismus may be an early symptom of invasive fungal rhinosinusitis, which may involve small basilar pontine perforating arteries, leading to a locked-in syndrome in immunosuppressed patients. Early recognition and treatment may prevent life-threatening neurologic complications.
authors.affiliation: Mayo Clinic College of Medicine, Department of Neurology, Rochester, MN 55905, USA.
authors.forename: Nathan P
authors.initials: NP
authors.lastname: Young
authors.forename: P James B
authors.initials: PJ
authors.lastname: Dyck
authors.forename: Eelco F M
authors.initials: EF
authors.lastname: Wijdicks
mesh_terms: D000328:Adult; D020526:Brain Stem Infarctions; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D008279:Magnetic Resonance Imaging / Q000379:methods; D009181:Mycoses / Q000150:complications*; D011782:Quadriplegia / Q000209:etiology* / Q000473:pathology; D012220:Rhinitis / Q000150:complications* / Q000209:etiology; D012852:Sinusitis / Q000150:complications* / Q000209:etiology