Human-hemato-lymphoid-system mice: opportunities and challenges.
With the recent advances in human-hemato-lymphoid-system mice, this commentary discusses the utility of these mice and further improvements required to generate an accessible system that allows predictive in vivo human hematology and immunology research.
Manz
Markus G
MG
Institute for Research in Biomedicine (IRB), Via Vincenzo Vela 6, CH-6500 Bellinzona, Switzerland. manz@irb.unisi.ch
D000818:Animals; D002454:Cell Differentiation; D003429:Cross Reactions / Q000276:immunology; D006413:Hematopoietic System / Q000166:cytology / Q000276:immunology*; D006801:Humans; D008214:Lymphocytes / Q000166:cytology / Q000276:immunology*; D051379:Mice