title: Potential role of thiol:disulfide oxidoreductases in the pathogenesis of Helicobacter pylori.
abstract: Helicobacter pylori infections are responsible for a sequence of molecular events which ultimately result in the development of gastric diseases. The pathogenesis of H. pylori has been studied extensively with strong focus on the identification of virulence factors. In contrast, the involvement of thiol:disulfide oxidoreductases in bacterial pathogenesis is less well understood. This paper provides a review of the current knowledge of H. pylori putative thiol:disulfide oxidoreductases, and their potential role in promoting virulence and colonization. Several bioinformatic analyses served to complete the information on these oxidoreductases of H. pylori.
authors.affiliation: School of Medical Sciences, The University of New South Wales, Sydney, Australia.
authors.forename: Nadeem O
authors.initials: NO
authors.lastname: Kaakoush
authors.forename: Zsuzsanna
authors.initials: Z
authors.lastname: Kovach
authors.forename: George L
authors.initials: GL
authors.lastname: Mendz
mesh_terms: D001426:Bacterial Proteins / Q000502:physiology*; D016481:Helicobacter Infections / Q000382:microbiology*; D016480:Helicobacter pylori / Q000201:enzymology* / Q000472:pathogenicity*; D006801:Humans; D011490:Protein Disulfide Reductase (Glutathione) / Q000502:physiology*; D014774:Virulence; D037521:Virulence Factors / Q000502:physiology*
chemical_list: D001426:Bacterial Proteins; D037521:Virulence Factors; D011490:Protein Disulfide Reductase (Glutathione)