title: Iriomoteolide-1a, a potent cytotoxic 20-membered macrolide from a benthic dinoflagellate amphidinium species.
abstract: A potent cytotoxic 20-membered macrolide, iriomoteolide-1a (1), has been isolated from a benthic dinoflagellate Amphidinium sp. (strain HYA024), and the structure was elucidated on the basis of detailed analyses of 2-D NMR data. The relative and absolute stereochemistries were assigned by the combination of conformational analyses using NMR data and modified Mosher's method of 1.
authors.affiliation: Center for Advanced Marine Core Research, Kochi University, Kochi 783-8502, Japan. mtsuda@kochi-u.ac.jp
authors.forename: Masashi
authors.initials: M
authors.lastname: Tsuda
authors.forename: Keiko
authors.initials: K
authors.lastname: Oguchi
authors.forename: Rie
authors.initials: R
authors.lastname: Iwamoto
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Okamoto
authors.forename: Jun'ichi
authors.initials: J
authors.lastname: Kobayashi
authors.forename: Eri
authors.initials: E
authors.lastname: Fukushi
authors.forename: Jun
authors.initials: J
authors.lastname: Kawabata
authors.forename: Tomoko
authors.initials: T
authors.lastname: Ozawa
authors.forename: Atsunori
authors.initials: A
authors.lastname: Masuda
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Kitaya
authors.forename: Kenji
authors.initials: K
authors.lastname: Omasa
mesh_terms: D000818:Animals; D004141:Dinoflagellida / Q000737:chemistry*; D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry / Q000302:isolation & purification; D008958:Models, Molecular; D008968:Molecular Conformation; D019906:Nuclear Magnetic Resonance, Biomolecular
chemical_list: D018942:Macrolides; C520799:iriomoteolide-1a