Enteropathy-type T-cell lymphoma.
Session 7 of the Society for Hematopathology/European Association for Haematopathology Workshop was devoted to case presentations and discussion of enteropathy-type T-cell lymphoma (ETL) and other T-cell lymphomas involving the gastrointestinal tract. ETL is a rare type of T-cell lymphoma, often associated with a history of celiac disease, that usually arises in the jejunum but can involve other gastrointestinal tract sites (eg, stomach and colon). As the cases submitted illustrate, there are 2 histologic groups of ETL that correlate with clinical and immunophenotypic features. Pleomorphic-anaplastic ETL is usually associated with a history of celiac disease and histologic evidence of enteropathy and is most often CD56-. Monomorphic ETL often occurs without a history of celiac disease, has variable histologic evidence of enteropathy, and is usually CD56+. Comparative genomic hybridization has shown recurrent chromosomal gains and losses that are characteristic of ETL and uncommon in other T-cell lymphomas, providing useful ancillary data for the diagnosis of ETL.
Zettl
Andreas
A
The Institute of Pathology, University of Würzburg, Würzburg, Germany.
deLeeuw
Ron
R
Haralambieva
Eugenia
E
Mueller-Hermelink
Hans-Konrad
HK
D019002:CD56 Antigen / Q000032:analysis; D002446:Celiac Disease / Q000473:pathology; D002869:Chromosome Aberrations; D002899:Chromosomes, Human, Pair 9; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007414:Intestinal Neoplasms / Q000145:classification / Q000235:genetics / Q000473:pathology*; D016399:Lymphoma, T-Cell / Q000145:classification / Q000235:genetics / Q000473:pathology*
D019002:CD56 Antigen