Please release me.
In this issue of Neuron, Südhof and colleagues determine which of the eight Ca(2+)-binding synaptotagmin isoforms expressed in brain can support synchronous neurotransmitter release at mammalian CNS synapses. Unexpectedly, only three-synaptotagmin-1, -2, and -9-can serve as Ca(2+) sensors for fast transmission. Further characterization reveals the unique ability of each isoform to shape neurotransmission.
Sullivan
Jane M
JM
Department of Physiology and Biophysics, University of Washington School of Medicine, Seattle, WA 98195, USA. jmsull@u.washington.edu
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D051379:Mice; D009474:Neurons / Q000166:cytology*; D013569:Synapses / Q000378:metabolism*; D009435:Synaptic Transmission / Q000502:physiology*; D050857:Synaptotagmins / Q000378:metabolism / Q000502:physiology
D050857:Synaptotagmins; D002118:Calcium