Simulation of GABA function in the basal ganglia: computational models of GABAergic mechanisms in basal ganglia function.
This chapter outlines current interpretation of computational aspects of GABAergic circuits of the striatum. Recent hypotheses and controversial matters are reviewed. Quantitative aspects of striatal synaptology relevant to computational models are considered, with estimates of the connectivity of the spiny projection neurons and fast-spiking interneurons. Against this background, insights into the computational properties of inhibitory circuits based on analysis and simulation of simple models are discussed. The paper concludes with suggestions for further theoretical and experimental studies.
Wickens
Jeffery R
JR
Basal Ganglia Research Group, School of Medical Sciences, University of Otago, Dunedin, New Zealand. jeff.wickens@stonebow.otago.ac.nz
Arbuthnott
Gordon W
GW
Shindou
Tomomi
T
D000200:Action Potentials / Q000502:physiology; D000818:Animals; D001479:Basal Ganglia / Q000033:anatomy & histology / Q000502:physiology*; D003198:Computer Simulation; D006801:Humans; D009433:Neural Inhibition / Q000502:physiology; D016571:Neural Networks, Computer; D009434:Neural Pathways / Q000033:anatomy & histology / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
D005680:gamma-Aminobutyric Acid