title: Inhibition of type III secretion in Salmonella enterica serovar Typhimurium by small-molecule inhibitors.
abstract: Type III secretion systems (T3SS) are conserved in many pathogenic gram-negative bacteria. Small molecules that specifically target T3SS in Yersinia and Chlamydia spp. have recently been identified. Here we show that two such compounds inhibit Salmonella T3SS-1, preventing secretion of T3SS-1 effectors, invasion of cultured epithelial cells, and enteritis in vivo.
authors.affiliation: Division of Microbiology, Institute for Animal Health, Compton, Berkshire RG20 7NN, United Kingdom.
authors.forename: Debra L
authors.initials: DL
authors.lastname: Hudson
authors.forename: Abigail N
authors.initials: AN
authors.lastname: Layton
authors.forename: Terry R
authors.initials: TR
authors.lastname: Field
authors.forename: Alison J
authors.initials: AJ
authors.lastname: Bowen
authors.forename: Hans
authors.initials: H
authors.lastname: Wolf-Watz
authors.forename: Mikael
authors.initials: M
authors.lastname: Elofsson
authors.forename: Mark P
authors.initials: MP
authors.lastname: Stevens
authors.forename: Edouard E
authors.initials: EE
authors.lastname: Galyov
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism*; D002417:Cattle; D004305:Dose-Response Relationship, Drug; D015394:Molecular Structure; D012486:Salmonella typhimurium / Q000145:classification / Q000378:metabolism* / Q000472:pathogenicity*; D012703:Serotyping
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins