[Genome instability and oncogenesis].
Molecular alterations leading to genetic instability play a key role in tumor development. The basic reasons of genetic instability of tumor cells, i.e. up-regulation of intracellular level of endogenous mutagens, in particular reactive oxygen spesies (ROS); decreased fidelity of DNA replication and chromosome segregation in mitosis; defects in DNA repair systems; and inactivation of cell cycle checkpoints preventing proliferation of abnormal cells are reviewed. In addition, tissue-specificity of tumorigenesis connected with genetic instability and development of new therapeutic approaches based on diminishing genetic instability or selective killing of neoplastic cells showing such defects are discussed.
Kopnin
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D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D020090:Chromosome Segregation; D004260:DNA Repair; D004261:DNA Replication; D042822:Genomic Instability / Q000235:genetics*; D006801:Humans; D008938:Mitosis; D009369:Neoplasms / Q000235:genetics*; D014158:Transcription, Genetic