title: Alpha-agarases define a new family of glycoside hydrolases, distinct from beta-agarase families.
abstract: The gene encoding the alpha-agarase from "Alteromonas agarilytica" (proposed name) has been cloned and sequenced. The gene product (154 kDa) is unrelated to beta-agarases and instead belongs to a new family of glycoside hydrolases (GH96). The alpha-agarase also displays a complex modularity, with the presence of five thrombospondin type 3 repeats and three carbohydrate-binding modules.
authors.affiliation: Centre National de la Recherche Scientifique, Université Pierre et Marie Curie-Paris6, Unité Mixte de Recherche 7139, Station Biologique, F-29682 Roscoff Cedex, Bretagne, France.
authors.forename: Didier
authors.initials: D
authors.lastname: Flament
authors.forename: Tristan
authors.initials: T
authors.lastname: Barbeyron
authors.forename: Murielle
authors.initials: M
authors.lastname: Jam
authors.forename: Philippe
authors.initials: P
authors.lastname: Potin
authors.forename: Mirjam
authors.initials: M
authors.lastname: Czjzek
authors.forename: Bernard
authors.initials: B
authors.lastname: Kloareg
authors.forename: Gurvan
authors.initials: G
authors.lastname: Michel
mesh_terms: D020591:Alteromonas / Q000201:enzymology* / Q000235:genetics*; D020816:Amino Acid Motifs; D000595:Amino Acid Sequence; D001665:Binding Sites / Q000235:genetics; D003001:Cloning, Molecular; D004269:DNA, Bacterial / Q000737:chemistry / Q000235:genetics; D006026:Glycoside Hydrolases / Q000737:chemistry / Q000235:genetics*; D008969:Molecular Sequence Data; D008970:Molecular Weight; D020449:Repetitive Sequences, Amino Acid; D017422:Sequence Analysis, DNA
chemical_list: D004269:DNA, Bacterial; D006026:Glycoside Hydrolases; C019624:agarase