title: Assessment of the multi-mycotoxin-binding efficacy of a carbon/aluminosilicate-based product in an in vitro gastrointestinal model.
abstract: A laboratory model, set to simulate the in vivo conditions of the porcine gastrointestinal tract, was used to study the small intestinal absorption of several mycotoxins and the effectiveness of Standard Q/FIS (a carbon/aluminosilicate-based product) in reducing mycotoxin absorption when added to multitoxin-contaminated diets. Mycotoxins were quickly absorbed in the proximal part of the small intestine at levels of 105 and 89% for fumonisins B1 and B2, respectively, 87% for ochratoxin A, 74% for deoxynivalenol, 44% for aflatoxin B1, and 25% for zearalenone. Addition of Standard Q/FIS to the diet (up to 2%, w/w) significantly reduced mycotoxin absorption, in a dose-dependent manner, up to 88% for aflatoxin B1, 44% for zearalenone, and 29% for the fumonisins and ochratoxin. Standard Q/FIS was ineffective in reducing deoxynivalenol uptake. These findings suggest that Standard Q/FIS can be used as a multitoxin adsorbent material to prevent the individual and combined adverse effects of mycotoxins in animals.
authors.affiliation: CNR Institute of Sciences of Food Production (ISPA), Via Amendola122/O, I-70126 Bari, Italy. giuseppina.avantaggiato@ispa.cnr.it
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Avantaggiato
authors.forename: Robert
authors.initials: R
authors.lastname: Havenaar
authors.forename: Angelo
authors.initials: A
authors.lastname: Visconti
mesh_terms: D000327:Adsorption; D000538:Aluminum Silicates; D000821:Animal Feed; D000818:Animals; D001665:Binding Sites; D002244:Carbon; D005746:Gastric Emptying / Q000502:physiology*; D041981:Gastrointestinal Tract / Q000502:physiology*; D005772:Gastrointestinal Transit; D006863:Hydrogen-Ion Concentration; D008954:Models, Biological; D009183:Mycotoxins / Q000032:analysis* / Q000378:metabolism; D013552:Swine
chemical_list: D000538:Aluminum Silicates; D009183:Mycotoxins; C049037:aluminosilicate; D002244:Carbon