Systemic mastocytosis in association with chronic lymphocytic leukemia: a rare diagnosis.
Systemic mastocytosis may be primary or be associated with other hematological malignancies, most commonly myeloid neoplasms. In contrast, the association of systemic mastocytosis with lymphoid neoplasms is comparatively rare, and in the absence of appropriate clinical vigilance the diagnosis may be missed. We report a case of aggressive systemic mastocytosis associated with chronic lymphocytic leukemia (SM-CLL), placing particular emphasis on the investigational algorithm used in establishing this diagnosis, and discussing key clinical considerations in the initiation of therapy.
Ault
Patricia
P
Leukemia Department, University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030 USA.
Lynn
Alice
A
Tam
Constantine S
CS
Medeiros
L Jeffrey
LJ
Keating
Michael J
MJ
D001856:Bone Marrow Examination; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications* / Q000175:diagnosis; D008297:Male; D034721:Mastocytosis, Systemic / Q000150:complications* / Q000175:diagnosis; D008875:Middle Aged; D016609:Neoplasms, Second Primary