Easy access to new heterocyclic systems: 1,4-oxazine and substituted 1,4-oxazines.
In the course of our investigations on the synthesis of new nitrogen heterocyclic derivatives, we were interested in the synthesis and study of new 1,4-oxazine rings. To this aim, the desired bisvinylphosphate was prepared from N-Boc morpholine-3,5-dione and was then engaged in palladium-catalyzed reactions (reduction, Suzuki, and Stille cross-coupling reactions). The 1,4-oxazine and its corresponding 3,5-disubstituted derivatives were obtained in fair to good yields and were then functionalized under anionic conditions.
Claveau
Elise
E
ICOA, UMR 6005, Université d'Orléans, BP 6759, 45067 Orléans cedex 2, France.
Gillaizeau
Isabelle
I
Blu
Jérome
J
Bruel
Amélie
A
Coudert
Gérard
G
D002384:Catalysis; D015394:Molecular Structure; D063065:Organophosphonates / Q000737:chemistry; D010078:Oxazines / Q000737:chemistry*; D014753:Vinyl Compounds / Q000737:chemistry
D063065:Organophosphonates; D010078:Oxazines; D014753:Vinyl Compounds; C433467:vinylphosphonic acid