Microbial Baeyer-Villiger oxidation of terpenones by recombinant whole-cell biocatalysts--formation of enantiocomplementary regioisomeric lactones.
Recombinant whole-cell expression systems for Baeyer-Villiger monooxygenases of various bacterial origin were utilized in the regiodivergent biooxidation of cyclic terpenones enabling access to enantio- and regioisomeric lactones on preparative scale.
Cernuchová
Petra
P
Institute of Applied Synthetic Chemistry, Vienna University of Technology, Getreidemarkt 9/163-OC, 1060 Vienna, Austria.
Mihovilovic
Marko D
MD
D002384:Catalysis; D004926:Escherichia coli / Q000166:cytology* / Q000378:metabolism*; D007659:Ketones / Q000737:chemistry / Q000378:metabolism*; D007783:Lactones / Q000737:chemistry* / Q000378:metabolism*; D006899:Mixed Function Oxygenases / Q000378:metabolism; D010082:Oxepins / Q000737:chemistry* / Q000378:metabolism*; D010084:Oxidation-Reduction; D013237:Stereoisomerism
D007659:Ketones; D007783:Lactones; D010082:Oxepins; D006899:Mixed Function Oxygenases