title: Plasma surfactant D in patients following acute paraquat intoxication.
abstract: Free radical-induced lung injury is a major problem that occurs because of paraquat intoxication. Serum surfactant protein D (SP-D) reflects the severity of various lung diseases. The purpose of this study is to investigate the changes in plasma SP-D concentrations and to correlate disease severity with SP-D concentrations in patients with acute paraqaut intoxication. Twelve paraquat-intoxicated patients participated in this study. Their paraquat exposure was assessed by their plasma's paraquat level. Serial plasma SP-Ds were measured by ELISA. SP-D was decreased two and three days after the initial measurement within 2 to 72 hours of ingestion. There was no difference in initial SP-D levels between survivors and non-survivors. The SP-D test revealed a significant positive correlation between the SP-D level and PaO(2) (r = 0.384, p = 0.003, N = 57). SP-D did not predict the likelihood of survival, but it was positively correlated with PaO(2). This finding suggests that low concentrations of plasma SP-D could reflect hypoxia due to free radical-induced injury.
authors.affiliation: Department of Internal Medicine, Soonchunhyang, University Cheonan Hospital, Cheonan, Republic of Korea.
authors.forename: Hyo-Wook
authors.initials: HW
authors.lastname: Gil
authors.forename: Jung-Rock
authors.initials: JR
authors.lastname: Hong
authors.forename: Jae-Ho
authors.initials: JH
authors.lastname: Park
authors.forename: Yun-Seok
authors.initials: YS
authors.lastname: Seo
authors.forename: Jong-Oh
authors.initials: JO
authors.lastname: Yang
authors.forename: Eun-Young
authors.initials: EY
authors.lastname: Lee
authors.forename: Sae-Yong
authors.initials: SY
authors.lastname: Hong
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006540:Herbicides / Q000097:blood / Q000506:poisoning*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D010269:Paraquat / Q000097:blood / Q000506:poisoning*; D037663:Pulmonary Surfactant-Associated Protein D / Q000097:blood*; D012720:Severity of Illness Index
chemical_list: D006540:Herbicides; D037663:Pulmonary Surfactant-Associated Protein D; D010269:Paraquat; D010100:Oxygen