title: The SHEDS-Wood model: incorporation of observational data to estimate exposure to arsenic for children playing on CCA-treated wood structures.
abstract: BACKGROUND
  Lumber treated with chromated copper arsenate (CCA) compounds has been used in residential outdoor wood structures and public playgrounds. The U.S. Environmental Protection Agency (EPA) has conducted a probabilistic assessment of children's exposure to arsenic using the Stochastic Human Exposure and Dose Simulation model for the wood preservative scenario (SHEDS-Wood). The assessment relied on data derived from an experimental study conducted using adult volunteers and designed to result in maximum hand and wipe loadings to estimate the residue-skin transfer efficiency. Recent analyses of arsenic hand-loading data generated by studies of children actively involved in playing on CCA-treated structures indicate that the transfer efficiency coefficient and hand-loading estimates derived from the experimental study significantly overestimate the amount that occurs during actual play.
  
  
  OBJECTIVE
  Our goal was to assess the feasibility of using child hand-loading data in the SHEDS-Wood model and their impact on exposure estimates.
  
  
  METHODS
  We used data generated by the larger of the studies of children in SHEDS-Wood, instead of the distributions used by U.S. EPA. We compared our estimates of the lifetime average daily dose (LADD) and average daily dose (ADD) with those derived by the U.S. EPA.
  
  
  RESULTS
  Our analysis indicates that data from observational studies of children can be used in SHEDS-Wood. Our estimates of the mean (and 95th percentile) LADD and ADD were 27% (10%) and 29% (15%) of the estimates derived by U.S. EPA.
  
  
  CONCLUSIONS
  We recommend that the SHEDS-Woods model use data from studies of children actively playing on playsets to more accurately estimate children's actual exposures to CCA.
authors.affiliation: Center for Chemical Regulation and Food Safety, Exponent, Inc., Washington, DC 20036, USA. lbarraj@exponent.com
authors.forename: Leila M
authors.initials: LM
authors.lastname: Barraj
authors.forename: Joyce S
authors.initials: JS
authors.lastname: Tsuji
authors.forename: Carolyn G
authors.initials: CG
authors.lastname: Scrafford
mesh_terms: D001149:Arsenates / Q000633:toxicity*; D002648:Child; D004781:Environmental Exposure; D006225:Hand; D006801:Humans; D008962:Models, Theoretical; D014481:United States; D014484:United States Environmental Protection Agency; D014934:Wood / Q000737:chemistry* / Q000633:toxicity
chemical_list: D001149:Arsenates; C040890:chromated copper arsenate