Kinetic study of DNA modification by phthalocyanine derivative of the oligonucleotide.
Design of chemically modified oligonucleotides for regulation of gene expression has attracted considerable attention over the last decades. One actively pursued approach involves antisense or antigene constructs carrying reactive groups, many of these based on transition metal complexes. The complexes of Co(II) with phthalocyanines are extremely good catalysts of oxidation of organic compounds with molecular oxygen and hydrogen peroxide. In this study, we have investigated the kinetics and thermodynamics of sequence-specific modification of DNA with deoxyribooligonucleotide linked to Co(II)-tetracarboxyphthalocyanine (PtcCo(II)) in the presence of H(2)O(2).
Kuznetsova
Alexandra A
AA
Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Novosibirsk 630090, Russia.
Chernonosov
Alexander A
AA
Kuznetsov
Nikita A
NA
Koval
Vladimir V
VV
Knorre
Dmitri G
DG
Fedorova
Olga S
OS