Identification of activated regions during a language task.
Functional magnetic resonance imaging (fMRI) techniques are based on the assumption that changes in neural activity are accompanied by modulation in the blood-oxygenation-level-dependent (BOLD) signal. In addition to conventional increases in BOLD signals, sustained negative BOLD signal changes are occasionally observed in many fMRI experiments, which show regions of cortex that seem to respond in antiphase with primary stimulus. The existence of this so-called negative BOLD response (NBR) has been observed and investigated in many functional studies. Several theoretical mechanisms have been proposed to account for it, but its origin has never been fully explained. In this study, the variability of fMRI activation, including the sources of the negative BOLD signal, during phonological and semantic language tasks, was investigated in six right-handed healthy subjects. We found significant activations in the brain regions, mainly in the left hemisphere, involved in the language stimuli [prominent in the inferior frontal gyrus, approximately Brodmann Areas (BA)7, BA44, BA45 and BA47, and in the precuneus]. Moreover, we observed activations in motor regions [precentral gyrus and supplementary motor area (SMA)], a result that suggests a specific role of these areas (particularly the SMA) in language processing. Functional analysis have also shown that certain brain regions, including the posterior cingulate cortex and the anterior cingulate cortex, have consistently greater activity during resting states compared to states of performing cognitive tasks. In our study, we observed diffuse NBR at the cortical level and a stronger negative response in correspondence to the main sinuses. These phenomena seem to be unrelated to a specific neural activity, appearing to be expressions of a mechanical variation in hemodynamics. We discussed about the importance of these responses that are anticorrelated with the stimulus. Our data suggest that particular care must be considered in the interpretation of fMRI findings, especially in the case of presurgical studies.
De Carli
Diego
D
MARBILab, Enrico Fermi Center, 00184 Rome, Italy.
Garreffa
Girolamo
G
Colonnese
Claudio
C
Giulietti
Giovanni
G
Labruna
Ludovica
L
Briselli
Ennio
E
Ken
Soléakhéna
S
Macrì
Maria Antonietta
MA
Maraviglia
Bruno
B
D000293:Adolescent; D000328:Adult; D001921:Brain / Q000033:anatomy & histology* / Q000473:pathology*; D001931:Brain Mapping / Q000379:methods*; D002540:Cerebral Cortex; D002560:Cerebrovascular Circulation; D003071:Cognition; D007839:Functional Laterality; D006801:Humans; D007802:Language; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009044:Motor Cortex / Q000473:pathology; D015203:Reproducibility of Results; D014705:Verbal Behavior