title: Animal models and vaccines for SARS-CoV infection.
abstract: We summarize findings of SARS-CoV infections in several animal models each of which support viral replication in lungs accompanied by histopathological changes and/or clinical signs of illness to varying degrees. New findings are reported on SARS-CoV replication and associated pathology in two additional strains (C57BL/6 and 129S6) of aged mice. We also provide new comparative data on viral replication and associated pathology following infection of golden Syrian hamsters with various SARS-CoV strains and report the levels of neutralizing antibody titers following these infections and the cross-protective efficacy of infection with these strains in protecting against heterologous challenge. Finally, we summarize findings of a variety of vaccine approaches and discuss the available in vitro and in vivo data addressing the potential for disease enhancement following re-infection in animals previously vaccinated against or infected with SARS-CoV.
authors.affiliation: Laboratory of Infectious Diseases, NIAID, NIH, Bethesda, MD, United States.
authors.forename: Anjeanette
authors.initials: A
authors.lastname: Roberts
authors.forename: Elaine W
authors.initials: EW
authors.lastname: Lamirande
authors.forename: Leatrice
authors.initials: L
authors.lastname: Vogel
authors.forename: Jadon P
authors.initials: JP
authors.lastname: Jackson
authors.forename: Christopher D
authors.initials: CD
authors.lastname: Paddock
authors.forename: Jeannette
authors.initials: J
authors.lastname: Guarner
authors.forename: Sherif R
authors.initials: SR
authors.lastname: Zaki
authors.forename: Timothy
authors.initials: T
authors.lastname: Sheahan
authors.forename: Ralph
authors.initials: R
authors.lastname: Baric
authors.forename: Kanta
authors.initials: K
authors.lastname: Subbarao
mesh_terms: D000818:Animals; D006224:Cricetinae; D004195:Disease Models, Animal; D005289:Ferrets; D006801:Humans; D007167:Immunotherapy; D008647:Mesocricetus; D051379:Mice; D008810:Mice, Inbred C57BL; D011323:Primates; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology; D045473:Severe acute respiratory syndrome-related coronavirus / Q000276:immunology / Q000502:physiology; D045169:Severe Acute Respiratory Syndrome / Q000276:immunology* / Q000517:prevention & control / Q000628:therapy / Q000821:virology; D015164:Vaccines, Inactivated / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology; D014765:Viral Vaccines / Q000008:administration & dosage* / Q000009:adverse effects / Q000276:immunology; D014779:Virus Replication
chemical_list: D011994:Recombinant Proteins; D015164:Vaccines, Inactivated; D014765:Viral Vaccines