Model of hyphal tip growth involving microtubule-based transport.
We propose a simple model for mass transport within a fungal hypha and its subsequent growth. Inspired by the role of microtubule-transported vesicles, we embody the internal dynamics of mass inside a hypha with mutually excluding particles progressing stochastically along a growing one-dimensional lattice. The connection between long-range transport of materials for growth and the resulting extension of the hyphal tip has not previously been addressed in the modeling literature to our knowledge. We derive and analyze mean-field equations for the model and present a phase diagram of its steady-state behavior, which we compare to simulations. We discuss our results in the context of the filamentous fungus Neurospora crassa.
Sugden
K E P
KE
SUPA, School of Physics, University of Edinburgh, Edinburgh EH9 3JZ, United Kingdom.
Evans
M R
MR
Poon
W C K
WC
Read
N D
ND
D001693:Biological Transport, Active / Q000502:physiology; D003198:Computer Simulation; D025301:Hyphae / Q000254:growth & development*; D008870:Microtubules / Q000502:physiology*; D008954:Models, Biological; D020409:Molecular Motor Proteins / Q000502:physiology*; D009492:Neurospora crassa / Q000254:growth & development* / Q000648:ultrastructure*
D020409:Molecular Motor Proteins