title: Gel dosimetry in the BNCT facility for extra-corporeal treatment of liver cancer at the HFR Petten.
abstract: A thorough evaluation of the dose inside a specially designed and built facility for extra-corporeal treatment of liver cancer by boron neutron capture therapy (BNCT) at the High Flux Reactor (HFR) Petten (The Netherlands) is the necessary step before animal studies can start. The absorbed doses are measured by means of gel dosemeters, which help to validate the Monte Carlo simulations of the spheroidal liver holder that will contain the human liver for irradiation with an epithermal neutron beam. These dosemeters allow imaging of the dose due to gammas and to the charged particles produced by the (10)B reaction. The thermal neutron flux is extrapolated from the boron dose images and compared to that obtained by the calculations. As an additional reference, Au, Cu and Mn foil measurements are performed. All results appear consistent with the calculations and confirm that the BNCT liver facility is able to provide an almost homogeneous thermal neutron distribution in the liver, which is a requirement for a successful treatment of liver metastases.
authors.affiliation: Department of Physics of the University of Milan and INFN, via Celoria, 16 - I-20133 Milan, Italy. grazia.gambarini@mi.infn.it
authors.forename: G
authors.initials: G
authors.lastname: Gambarini
authors.forename: G G
authors.initials: GG
authors.lastname: Daquino
authors.forename: R L
authors.initials: RL
authors.lastname: Moss
authors.forename: M
authors.initials: M
authors.lastname: Carrara
authors.forename: V A
authors.initials: VA
authors.lastname: Nievaart
authors.forename: E
authors.initials: E
authors.lastname: Vanossi
mesh_terms: D016754:Boron Neutron Capture Therapy / Q000295:instrumentation* / Q000379:methods; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005782:Gels / Q000528:radiation effects*; D006801:Humans; D007558:Italy; D008113:Liver Neoplasms / Q000532:radiotherapy*; D009502:Neutrons; D011874:Radiometry / Q000295:instrumentation* / Q000379:methods; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000295:instrumentation* / Q000379:methods; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D005782:Gels