title: Skin cancers and precancerous lesions in Parkinson's disease patients.
abstract: Our objective was to evaluate the frequency of neoplastic and preneoplastic skin lesions in Parkinson's disease (PD) patients when compared with an aged-matched population. We performed a cross-sectional survey in PD patients and in an age-matched control group. Patients and controls were examined by a movement disorder specialist and a dermatologist. 150 PD patients and 146 controls were included. Thirty-five PD patients (23.3%) presented skin lesions that could be classified as neoplastic or preneoplastic vs. 20 subjects in the control group (13.7%) (OR 95%, CI 1.92 [1.05, 3.51]). However, this difference lost statistical significance when adjusted for gender (recruitment of controls was matched just for age with an over representation of males in the PD group). Twenty-nine PD patients (19%) presented actinic keratosis and basal cell carcinoma was diagnosed in 4 patients (3%). Although nonconclusive, our results are in agreement with previous studies suggesting an increased risk of skin cancer in PD patients. The frequency of actinic keratosis in PD patients and the associated risk to develop melanoma recommends its screening in future epidemiological studies.
authors.affiliation: Neurological Clinic Research Unit, Institute of Molecular Medicine, Lisbon School of Medicine, Lisbon, Portugal.
authors.forename: Joaquim
authors.initials: J
authors.lastname: Ferreira
authors.affiliation: Dermatology Department, Hospital de Santa Maria, Lisbon, Portugal.
authors.forename: João Maia
authors.initials: JM
authors.lastname: Silva
authors.affiliation: Neurological Clinic Research Unit, Institute of Molecular Medicine, Lisbon School of Medicine, Lisbon, Portugal.
authors.forename: Rita
authors.initials: R
authors.lastname: Freire
authors.affiliation: Dermatology Department, Hospital de Santa Maria, Lisbon, Portugal.
authors.forename: João
authors.initials: J
authors.lastname: Pignatelli
authors.affiliation: Neurological Clinic Research Unit, Institute of Molecular Medicine, Lisbon School of Medicine, Lisbon, Portugal.
authors.forename: Leonor Correia
authors.initials: LC
authors.lastname: Guedes
authors.affiliation: Dermatology Department, Hospital de Santa Maria, Lisbon, Portugal.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Feijó
authors.affiliation: Neurological Clinic Research Unit, Institute of Molecular Medicine, Lisbon School of Medicine, Lisbon, Portugal.
authors.forename: Mário Miguel
authors.initials: MM
authors.lastname: Rosa
authors.affiliation: Neurological Clinic Research Unit, Institute of Molecular Medicine, Lisbon School of Medicine, Lisbon, Portugal.
authors.forename: Miguel
authors.initials: M
authors.lastname: Coelho
authors.affiliation: Neurological Clinic Research Unit, Institute of Molecular Medicine, Lisbon School of Medicine, Lisbon, Portugal.
authors.forename: João
authors.initials: J
authors.lastname: Costa
authors.affiliation: Neurological Clinic Research Unit, Institute of Molecular Medicine, Lisbon School of Medicine, Lisbon, Portugal.
authors.forename: Ana
authors.initials: A
authors.lastname: Noronha
authors.affiliation: Neurological Clinic Research Unit, Institute of Molecular Medicine, Lisbon School of Medicine, Lisbon, Portugal.
authors.forename: Russell
authors.initials: R
authors.lastname: Hewett
authors.affiliation: Dermatology Department, Hospital de Santa Maria, Lisbon, Portugal.
authors.forename: A Marques
authors.initials: AM
authors.lastname: Gomes
authors.affiliation: Dermatology Department, Hospital de Santa Maria, Lisbon, Portugal.
authors.forename: J L Cirne
authors.initials: JLC
authors.lastname: de Castro
authors.affiliation: Clinical Investigation Centre, Department of Clinical Pharmacology and Neurosciences, University Hospital, Toulouse, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Rascol
authors.affiliation: Neurological Clinic Research Unit, Institute of Molecular Medicine, Lisbon School of Medicine, Lisbon, Portugal.
authors.forename: Cristina
authors.initials: C
authors.lastname: Sampaio
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D016001:Confidence Intervals; D018592:Cross-Over Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010300:Parkinson Disease / Q000503:physiopathology*; D011230:Precancerous Conditions / Q000503:physiopathology*; D012307:Risk Factors; D012878:Skin Neoplasms / Q000503:physiopathology*; D011795:Surveys and Questionnaires