title: Effect of early interferon beta-1a therapy on conversion to multiple sclerosis in Iranian patients with a first demyelinating event.
abstract: BACKGROUND
  A new treatment approach to multiple sclerosis (MS) is the initiation of interferon therapy in the early phase of the disease when a patient presents with clinically isolated syndrome.
  
  
  OBJECTIVE
  The goal of this study was to assess the effect of early treatment on the risk of conversion to clinically definite MS in Iranian patients.
  
  
  METHODS
  Eligible patients had presented with a first episode of neurological dysfunction suggesting MS within the previous 3 months and had abnormal brain magnetic resonance imaging (MRI). Patients were randomly assigned to receive intramuscular interferon beta 1a 30 mug or placebo once a week for 3 years.
  
  
  RESULTS
  Of the 217 patients randomized, 202 patients completed the study; 104 received Avonex and 98 received placebo. Fewer patients converted to clinically definite multiple sclerosis in the treated group than in the placebo group during the study (36.6% vs 58.2%, P < 0.003). The number of active T2-weighted MRI lesions was significantly lower in the treated group.
  
  
  CONCLUSIONS
  The results of our study, which are consistent with those from western studies, show that treatment at an early stage of MS delays conversion to definite MS and has positive effects on MRI outcomes.
authors.affiliation: Department of Neurology, Shahid Beheshti University of Medical Sciences, Loghman Haskim Street, Tehran 789065, Iran. hossienpakdaman@yahoo.com
authors.forename: H
authors.initials: H
authors.lastname: Pakdaman
authors.forename: M A
authors.initials: MA
authors.lastname: Sahraian
authors.forename: A
authors.initials: A
authors.lastname: Fallah
authors.forename: R
authors.initials: R
authors.lastname: Pakdaman
authors.forename: K
authors.initials: K
authors.lastname: Ghareghozli
authors.forename: M
authors.initials: M
authors.lastname: Ghafarpour
authors.forename: E
authors.initials: E
authors.lastname: Rahimian
authors.forename: A
authors.initials: A
authors.lastname: Shirani
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage*; D000328:Adult; D001921:Brain / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology; D003711:Demyelinating Diseases / Q000188:drug therapy / Q000503:physiopathology; D018450:Disease Progression; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D000068556:Interferon beta-1a; D016899:Interferon-beta / Q000008:administration & dosage*; D007492:Iran; D008279:Magnetic Resonance Imaging; D008297:Male; D009103:Multiple Sclerosis / Q000188:drug therapy* / Q000503:physiopathology / Q000517:prevention & control*; D015990:Placebo Effect; D016896:Treatment Outcome
chemical_list: D000276:Adjuvants, Immunologic; D016899:Interferon-beta; D000068556:Interferon beta-1a