title: Paradoxical embolus illustrating speed of action of recombinant tissue plasminogen activator in massive pulmonary embolism.
abstract: A case of a patient who presented with massive pulmonary embolism (PE) requiring thrombolysis with alteplase is reported. The subsequent presence of a patent foramen ovale and paradoxical embolism clinically demonstrated the speed of action of the recombinant tissue plasminogen activator. The advantage of this class of medication when considering the treatment options for a PE in an acute setting is highlighted.
authors.affiliation: Royal Free NHS Trust Hospital, Pond Street, London NW3 2QG, UK. h.madani@doctors.org.uk
authors.forename: H
authors.initials: H
authors.lastname: Madani
authors.forename: P A
authors.initials: PA
authors.lastname: Ransom
mesh_terms: D000328:Adult; D004305:Dose-Response Relationship, Drug; D019320:Embolism, Paradoxical / Q000150:complications / Q000188:drug therapy*; D005260:Female; D005263:Femoral Artery; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006801:Humans; D011655:Pulmonary Embolism / Q000150:complications / Q000188:drug therapy*; D015912:Thrombolytic Therapy / Q000379:methods; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D005343:Fibrinolytic Agents; D010959:Tissue Plasminogen Activator