title: [Panton-Valentine leukocidin-producing Staphylococcus aureus responsible for necrotizing pneumonia].
abstract: Panton-Valentine leukocidin-producing (PVL) Staphylococcus aureus is responsible for a highly lethal necrotizing pneumonia, which occurs predominantly in young immunocompetent patients. Hemoptysis and leucopenia often occur but are not always present. Detection of PVL gene on S. aureus strains responsible for pneumonia should help us to a better understanding of this disease, to improve its treatment with antibiotics capable of lower the toxin production and to prevent its diffusion to others persons by detection and elimination of a nasal S. aureus carriage.
authors.affiliation: Service de biologie, HIA Robert Picque, Bordeaux, France.
authors.forename: P
authors.initials: P
authors.lastname: Dubrous
authors.forename: A
authors.initials: A
authors.lastname: Cuguillère
authors.forename: A
authors.initials: A
authors.lastname: Gendrot
authors.forename: J-L
authors.initials: JL
authors.lastname: Koeck
mesh_terms: D000328:Adult; D001427:Bacterial Toxins / Q000096:biosynthesis*; D005098:Exotoxins / Q000096:biosynthesis*; D006801:Humans; D007956:Leukocidins / Q000096:biosynthesis*; D008297:Male; D009336:Necrosis; D011023:Pneumonia, Staphylococcal / Q000150:complications / Q000382:microbiology* / Q000473:pathology; D013211:Staphylococcus aureus / Q000378:metabolism*
chemical_list: D001427:Bacterial Toxins; D005098:Exotoxins; D007956:Leukocidins; C078284:Panton-Valentine leukocidin