title: Hodgkin's lymphoma in a patient with Jo-1 syndrome.
abstract: Jo-1 syndrome is an autoimmune disease with autoantibodies against the histidyl tRNA synthetase. Characteristic clinical findings include inflammatory myopathy and interstitial lung disease. We present the first case of a patient with Jo-1 syndrome (positive Jo-1 autoantibodies, myositis, interstitial alveolitis) who developed Hodgkin's lymphoma of nodular-sclerosing type. Thus, patients with Jo-1 syndrome and immunosuppressive therapy similar to other patients with autoimmune disease are at risk to develop lymphomas and should therefore be monitored carefully.
authors.affiliation: Department of Pathology, University of Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany. alexander.adam@ukb.uni-bonn.de
authors.forename: Alexander C
authors.initials: AC
authors.lastname: Adam
authors.forename: Christian
authors.initials: C
authors.lastname: Grohé
authors.forename: Sebastian
authors.initials: S
authors.lastname: Stier
authors.forename: Stefan
authors.initials: S
authors.lastname: Gattenlöhner
authors.forename: Zeynep
authors.initials: Z
authors.lastname: Balta
authors.forename: Reinhard
authors.initials: R
authors.lastname: Büttner
authors.forename: Ines
authors.initials: I
authors.lastname: Gütgemann
mesh_terms: D000974:Antibodies, Antinuclear / Q000097:blood*; D000914:Antibodies, Viral / Q000097:blood; D006689:Hodgkin Disease / Q000209:etiology*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009220:Myositis / Q000150:complications*; D011658:Pulmonary Fibrosis / Q000150:complications*; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000235:genetics; D013577:Syndrome
chemical_list: D000974:Antibodies, Antinuclear; D000914:Antibodies, Viral; C046750:Jo-1 antibody; D016692:Receptors, Antigen, T-Cell, gamma-delta