[Screening of biopolymers from sea hydrocoles affecting the adsorption of Hantaan virus].
The biopolymers extracted from sea hydrocoles were screened and a group of sulfated polysaccharides--fucoidans having a pronounced inhibitory effect on the adsorption of Hantaan virus in the cultured Vero E6 cells was identified. The mechanism of action of sulfated polysaccharides was realized through competitive carbohydrate-specific binding to cell membrane receptors and through ligand-receptor interaction and blocking of Hantaan virus glycoproteins (G1 and G2).
Makarenkova
I D
ID
Kompanets
G G
GG
Besednova
N N
NN
Slonova
R A
RA
Zviagintseva
T N
TN
Shevchenko
N M
NM
D000818:Animals; D001704:Biopolymers / Q000494:pharmacology*; D002522:Chlorocebus aethiops; D056890:Eukaryota / Q000737:chemistry; D018063:Hantaan virus / Q000187:drug effects* / Q000502:physiology; D008386:Marine Biology; D049878:Mytilus / Q000737:chemistry; D009792:Oceans and Seas; D011134:Polysaccharides / Q000494:pharmacology; D013431:Sulfates / Q000494:pharmacology; D014709:Vero Cells; D014779:Virus Replication / Q000187:drug effects; D035962:Zosteraceae / Q000737:chemistry
D001704:Biopolymers; D011134:Polysaccharides; D013431:Sulfates