A genomewide admixture map for Latino populations.
Admixture mapping is an economical and powerful approach for localizing disease genes in populations of recently mixed ancestry and has proven successful in African Americans. The method holds equal promise for Latinos, who typically inherit a mix of European, Native American, and African ancestry. However, admixture mapping in Latinos has not been practical because of the lack of a map of ancestry-informative markers validated in Native American and other populations. To address this, we screened multiple databases, containing millions of markers, to identify 4,186 markers that were putatively informative for determining the ancestry of chromosomal segments in Latino populations. We experimentally validated each of these markers in at least 232 new Latino, European, Native American, and African samples, and we selected a subset of 1,649 markers to form an admixture map. An advantage of our strategy is that we focused our map on markers distinguishing Native American from other ancestries and restricted it to markers with very similar frequencies in Europeans and Africans, which decreased the number of markers needed and minimized the possibility of false disease associations. We evaluated the effectiveness of our map for localizing disease genes in four Latino populations from both North and South America.
Price
Alkes L
AL
Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Patterson
Nick
N
Yu
Fuli
F
Cox
David R
DR
Waliszewska
Alicja
A
McDonald
Gavin J
GJ
Tandon
Arti
A
Schirmer
Christine
C
Neubauer
Julie
J
Bedoya
Gabriel
G
Duque
Constanza
C
Villegas
Alberto
A
Bortolini
Maria Catira
MC
Salzano
Francisco M
FM
Gallo
Carla
C
Mazzotti
Guido
G
Tello-Ruiz
Marcela
M
Riba
Laura
L
Aguilar-Salinas
Carlos A
CA
Canizales-Quinteros
Samuel
S
Menjivar
Marta
M
Klitz
William
W
Henderson
Brian
B
Haiman
Christopher A
CA
Winkler
Cheryl
C
Tusie-Luna
Teresa
T
Ruiz-Linares
Andres
A
Reich
David
D
D000483:Alleles; D044383:Black People; D016022:Case-Control Studies; D002874:Chromosome Mapping; D002877:Chromosomes, Human; D003198:Computer Simulation; D030541:Databases, Genetic; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D005828:Genetics, Population; D015894:Genome, Human; D006630:Hispanic or Latino / Q000235:genetics*; D006801:Humans; D007198:Indians, North American; D015203:Reproducibility of Results; D044465:White People; D001741:Black or African American
D005819:Genetic Markers