Acute toxicity of Orthosiphon stamineus Benth standardized extract in Sprague Dawley rats.
The acute toxicity of standardized extract of Orthosiphon stamineus was studied in Sprague Dawley rats. The rats were administered a single dose of 5000 mg/kg body weight (BW) orally on Day 0 and observed for 14 days. There were no deaths recorded and the animals did not show signs of toxicity during the experimental period. The effect of the extract on general behavior, BW, food and water intake, relative organ weight per 100 g BW, hematology and clinical biochemistry were measured. All the parameters measured were unaffected as compared to the control. The acute toxicity LD(50) was estimated to be > 5000 mg/kg BW.
Abdullah
Noor Rain
NR
Herbal Medicine Research Center, Institute for Medical Research, Jalan Pahang 50588, Kuala Lumpur, Malaysia. noorrain@imr.gov.my
Ismail
Zakiah
Z
Ismail
Zhari
Z
D000704:Analysis of Variance; D000818:Animals; D001774:Blood Chemical Analysis; D001835:Body Weight / Q000187:drug effects; D004326:Drinking / Q000187:drug effects; D002149:Energy Intake / Q000187:drug effects; D006403:Hematologic Tests; D007928:Lethal Dose 50; D009929:Organ Size / Q000187:drug effects; D031342:Orthosiphon / Q000633:toxicity*; D010936:Plant Extracts / Q000633:toxicity*; D018515:Plant Leaves; D051381:Rats; D017207:Rats, Sprague-Dawley
D010936:Plant Extracts