title: Genetics of epilepsy: epilepsy research foundation workshop report.
abstract: The Sixth Epilepsy Research Foundation workshop, held in Oxford in March 2006, brought together basic scientists, geneticists, epidemiologists, statisticians, pharmacologists and clinicians to consider progress, issues and strategies for harnessing genetics to improve the understanding and treatment of the epilepsies. General principles were considered, including the fundamental importance of clear study design, adequate patient numbers, defi ned phenotypes, robust statistical data handling, and follow-up of genetic discoveries. Topics where some progress had been made were considered including chromosomal abnormalities, neurodevelopment, hippocampal sclerosis, juvenile myoclonic epilepsy, focal cortical dysplasia and pharmacogenetics. The ethical aspects of epilepsy genetics were reviewed. Principles and limitations of collaboration were discussed. Presentations and their matched discussions are produced here. There was optimism that further genetic research in epilepsy was not only feasible, but might lead to improvements in the lives of people with epilepsy.
authors.affiliation: Epilepsy Research Foundation, United Kingdom.
authors.forename: Sanjay
authors.initials: S
authors.lastname: Sisodiya
authors.forename: J Helen
authors.initials: JH
authors.lastname: Cross
authors.forename: Ingmar
authors.initials: I
authors.lastname: Blümcke
authors.forename: David
authors.initials: D
authors.lastname: Chadwick
authors.forename: John
authors.initials: J
authors.lastname: Craig
authors.forename: Peter B
authors.initials: PB
authors.lastname: Crino
authors.forename: Paul
authors.initials: P
authors.lastname: Debenham
authors.forename: Norman
authors.initials: N
authors.lastname: Delanty
authors.forename: Frances
authors.initials: F
authors.lastname: Elmslie
authors.forename: Mark
authors.initials: M
authors.lastname: Gardiner
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Golden
authors.forename: David
authors.initials: D
authors.lastname: Goldstein
authors.forename: David A
authors.initials: DA
authors.lastname: Greenberg
authors.forename: Renzo
authors.initials: R
authors.lastname: Guerrini
authors.forename: Michael
authors.initials: M
authors.lastname: Hanna
authors.forename: John
authors.initials: J
authors.lastname: Harris
authors.forename: Paul
authors.initials: P
authors.lastname: Harrison
authors.forename: Michael R
authors.initials: MR
authors.lastname: Johnson
authors.forename: George
authors.initials: G
authors.lastname: Kirov
authors.forename: Dimitri M
authors.initials: DM
authors.lastname: Kullman
authors.forename: Andrew
authors.initials: A
authors.lastname: Makoff
authors.forename: Carla
authors.initials: C
authors.lastname: Marini
authors.forename: Rima
authors.initials: R
authors.lastname: Nabbout
authors.forename: Lina
authors.initials: L
authors.lastname: Nashef
authors.forename: Jeffrey L
authors.initials: JL
authors.lastname: Noebels
authors.forename: Ruth
authors.initials: R
authors.lastname: Ottman
authors.forename: Munir
authors.initials: M
authors.lastname: Pirmohamed
authors.forename: Asla
authors.initials: A
authors.lastname: Pitkänen
authors.forename: Ingrid
authors.initials: I
authors.lastname: Scheffer
authors.forename: Simon
authors.initials: S
authors.lastname: Shorvon
authors.forename: Graeme
authors.initials: G
authors.lastname: Sills
authors.forename: Nicholas
authors.initials: N
authors.lastname: Wood
authors.forename: Sameer
authors.initials: S
authors.lastname: Zuberi
mesh_terms: D000927:Anticonvulsants / Q000627:therapeutic use; D004827:Epilepsy / Q000188:drug therapy / Q000235:genetics*; D032984:Ethics, Research; D006801:Humans; D010597:Pharmacogenetics; D012107:Research Design / Q000592:standards
chemical_list: D000927:Anticonvulsants