Genes and respiratory disease: a first step on a long journey.
This review highlights the critical importance of phenotype definition in the understanding of the pathogenesis of respiratory disease in horses. The general approach to genetic studies is discussed and comparative studies of recurrent airway obstruction (RAO) conditions, such as asthma, described in the context of learning more about equivalent equine conditions. The availability of methods to study genetic tests have previously relied on DNA sequence knowledge from man, laboratory and domesticated animals, but recent data from the horse genome sequence are now available. This should facilitate advances in the identification of specific genes for equine diseases. The review summarises the future potential for such studies and places the report in this issue (p 236) by Jost et al. (2007) of the involvement of IL4RA as a candidate gene in RAO into this context.
Ewart
S L
SL
Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan 4882-1314, USA.
Robinson
N E
NE
D000818:Animals; D020022:Genetic Predisposition to Disease; D006734:Horse Diseases / Q000235:genetics*; D006736:Horses; D010641:Phenotype; D012140:Respiratory Tract Diseases / Q000235:genetics / Q000662:veterinary*