[Effect of losartan on the state of kidney function in rats with experimental hyperthyroidism].
The effect of losartan on the functional state of kidneys was studied in white rats with the experimental hyperthyroidism caused by a 5-day oral administration exogenous T4 thyroxine in a dose of 50 microg/(100 g body weight). Then, the test rats were divided into two groups and animals in the first group received water, while animals in the second group were treated with a losartan solution (10 mg/1) during 24 hours. Then, the function of kidneys was studied under the condition of 5% water loading. It was established, that T4 injections resulted in a decrease of the clearance of creatinine and an increase in the renal excretion of albumin and osmotically active substances. The administration of losartan increased the clearance of creatinine and reduced the excretion of albumen via the kidneys. The renal effect of losartan is indicative of a reversible character of changes in the functional state of kidneys in this stage of experimental pathology.
Zaporozhan
V N
VN
Dolomatov
S I
SI
D047228:Angiotensin II Type 1 Receptor Blockers / Q000494:pharmacology*; D000818:Animals; D003404:Creatinine / Q000097:blood; D004195:Disease Models, Animal; D006980:Hyperthyroidism / Q000188:drug therapy* / Q000503:physiopathology; D007668:Kidney / Q000187:drug effects* / Q000503:physiopathology; D019808:Losartan / Q000494:pharmacology*; D008297:Male; D051381:Rats; D013974:Thyroxine / Q000494:pharmacology*
D047228:Angiotensin II Type 1 Receptor Blockers; D003404:Creatinine; D019808:Losartan; D013974:Thyroxine