Current role of LC-MS in therapeutic drug monitoring.
The role of liquid chromatography coupled with mass spectrometry (LC-MS) techniques in routine therapeutic drug monitoring activity is becoming increasingly important. This paper reviews LC-MS methods published in the last few years for certain classes of drugs subject to therapeutic drug monitoring: immunosuppressants, antifungal drugs, antiretroviral drugs, antidepressants and antipsychotics. For each class of compounds, we focussed on the most interesting methods and evaluated the current role of LC-MS in therapeutic drug monitoring.
Saint-Marcoux
Franck
F
Department of Pharmacology-Toxicology, Limoges University Hospital, Unité INSERM U850, 87042 Limoges cedex, France.
Sauvage
François-Ludovic
FL
Marquet
Pierre
P
D002853:Chromatography, Liquid; D016903:Drug Monitoring / Q000379:methods*; D006801:Humans; D013058:Mass Spectrometry; D004364:Pharmaceutical Preparations / Q000032:analysis
D004364:Pharmaceutical Preparations