title: pH responsiveness of block copolymer vesicles with a polypeptide corona.
abstract: The aggregation behavior of polybutadiene165-block-poly(L-lysine)88 in saline solution was studied by combined static and dynamic light scattering analyses. Vesicles were observed if the polypeptide segment was in a 100% coil conformation (pH 7.0) or in an 80% alpha-helical conformation (pH 10.3). At the higher pH, aggregates were smaller in size (hydrodynamic radius: 364 nm --> 215 nm) and chains were more densely packed at the core-corona interface (interchain distance: 3.2 nm --> 2.4 nm). Changes in size and structure could be explained in basic terms of colloid stabilization without considering a secondary structure effect.
authors.affiliation: Max Planck Institute of Colloids and Interfaces, Colloid Chemistry, Research Campus Golm, 14424 Potsdam, Germany.
authors.forename: Reinhard
authors.initials: R
authors.lastname: Sigel
authors.forename: Magdalena
authors.initials: M
authors.lastname: Łosik
authors.forename: Helmut
authors.initials: H
authors.lastname: Schlaad
mesh_terms: D002070:Butadienes / Q000737:chemistry*; D003102:Colloids; D020724:Elastomers / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D011107:Polylysine / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D017433:Protein Structure, Secondary
chemical_list: D002070:Butadienes; D003102:Colloids; D020724:Elastomers; D011108:Polymers; D011107:Polylysine; C028834:polybutadiene