title: [Regulatory peptides and psychomotor development in infants].
abstract: Regulatory peptides (RP) are an important homeostatic factor. The maternal organism and placenta are substantial sources of RP for fetus during the prenatal period. Not only endogenous, but also exogenous RP play an important role during early postnatal period. In this study, the concentration of exogenous RP (casomorphins-7) and the activity of peptidases (enkephalinases) in the serum of breastfed and bottle-fed infants were estimated. Possible interrelation between these two parameters and the psychomotor development (PMD) of infants were evaluated. Using specially developed RIA, the investigators estimated the presence of human and bovine casomorphins immunoreactivity (CMir) in the serum of breastfed and bottle-fed infants. A distinct correlation of CMir with PMD was demonstrated. The activity of RP-degrading serum enzymes also correlated with PMD level. The role of endo- and exogenous peptides in normal PMD process and in the pathogenesis of early child autism is discussed in the article.
authors.forename: O Iu
authors.initials: OIu
authors.lastname: Sokolov
authors.forename: N V
authors.initials: NV
authors.lastname: Kost
authors.forename: O B
authors.initials: OB
authors.lastname: Kurasova
authors.forename: A D
authors.initials: AD
authors.lastname: Dmitriev
authors.forename: M V
authors.initials: MV
authors.lastname: Gabaeva
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Zolotarev
authors.forename: I G
authors.initials: IG
authors.lastname: Mikheeva
authors.forename: A A
authors.initials: AA
authors.lastname: Zozulia
mesh_terms: D001321:Autistic Disorder / Q000209:etiology; D001903:Bottle Feeding; D001942:Breast Feeding; D002364:Caseins; D002657:Child Development / Q000502:physiology; D003627:Data Interpretation, Statistical; D004723:Endorphins / Q000097:blood*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D015260:Neprilysin / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D011863:Radioimmunoassay
chemical_list: D002364:Caseins; D004723:Endorphins; D010446:Peptide Fragments; C041128:beta-casomorphin 7; D015260:Neprilysin