Contamination of peripheral hematopoeitic stem cell products with a Mycobacterium mucogenicum-related pathogen.
A gram-positive rod with a restriction pattern closely related to the published nucleotide sequence of Mycobacterium mucogenicum was isolated from 6 of 45 units of peripheral blood stem cell products. The source of the contamination was traced to ice cubes used in processing the peripheral blood stem cell products. Substituting reusable ice trays for ice from an ice machine terminated the outbreak.
Kassis
Imad
I
Infectious Diseases Unit, Meyer Children's Hospital, Rambam Medical Center, and Bruce-Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel. i_kassis@rambam.health.gov.il
Oren
Ilana
I
Davidson
Sima
S
Finkelstein
Renato
R
Rabino
Galit
G
Katz
Tami
T
Sprecher
Hannah
H
D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D016026:Bone Marrow Transplantation; D004196:Disease Outbreaks / Q000517:prevention & control; D004866:Equipment Contamination; D006412:Hematopoietic Stem Cells / Q000382:microbiology*; D006801:Humans; D007053:Ice / Q000009:adverse effects*; D017053:Infection Control / Q000379:methods; D009161:Mycobacterium / Q000302:isolation & purification*; D009164:Mycobacterium Infections / Q000188:drug therapy / Q000382:microbiology*; D016133:Polymerase Chain Reaction
D000900:Anti-Bacterial Agents; D007053:Ice