title: Laparoscopic cholecystectomy versus mini-laparotomy cholecystectomy: a meta-analysis of randomised control trials.
abstract: OBJECTIVE
  To use meta-analytic techniques to compare peri-operative and short term post-operative outcomes for patients undergoing cholecystectomy via the laparoscopic or mini-open approach.
  
  
  METHODS
  Randomised control trials published between 1992 and 2005, cited in the literature of elective laparoscopic (LC) versus mini-open cholecystectomy (MoC) for symptomatic gallstone disease were included. End points evaluated were adverse events, operative and functional outcomes. A random effects meta-analytical model was used and between-study heterogeneity assessed. Subgroup analysis was performed to evaluate the difference in results for study size and quality and data reported from 2000.
  
  
  RESULTS
  Nine randomised studies of 2032 patients were included in the analysis. There was considerable variation in the size and type of incision used for MoC in the studies. There was a significantly longer operating time for the LC group, by 14.14 minutes (95% CI 2.08, 26.19; p < 0.0001). Length of stay was reduced in the LC group by 0.37 days (95% CI -0.53, -0.21; p < 0.0001), with no significant heterogeneity for either outcome. For all other operative and post-operative outcomes, there was no significant difference between the two groups.
  
  
  CONCLUSIONS
  MoC appeared to have similar outcomes compared to LC, however LC did reduce the length of hospital stay. MoC is a viable and safe option for healthcare providers without the financial resources for laparoscopic equipment and appropriately trained surgical teams.
authors.affiliation: Department of Biosurgery and Surgical Technology, Imperial College, St. Mary's Hospital, London, UK.
authors.forename: Sanjay
authors.initials: S
authors.lastname: Purkayastha
authors.forename: Henry S
authors.initials: HS
authors.lastname: Tilney
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Georgiou
authors.forename: Thanos
authors.initials: T
authors.lastname: Athanasiou
authors.forename: Paris P
authors.initials: PP
authors.lastname: Tekkis
authors.forename: Ara W
authors.initials: AW
authors.lastname: Darzi
mesh_terms: D002763:Cholecystectomy / Q000379:methods; D017081:Cholecystectomy, Laparoscopic; D006801:Humans; D007813:Laparotomy; D019060:Minimally Invasive Surgical Procedures; D016032:Randomized Controlled Trials as Topic