[The role of the ovarian steroid aromatase in pathogenesis of reproductive cycles disorders].
In the rats with regular estrous cycles effects of letrozole, a steroid aromatase inhibitor, on the enzyme activity in ovarian tissues and reproductive system condition were studied. Letrozole was administered per os daily in a dose of 1 mg/kg b.w. over 10 days. As the result of treatment, 20.5-fold decrease in aromatase activity was obtained. All animals have developed persistent anestrus with vaginal smear patterns being similar to diestrus. Uterine weights were two-fold less than that of controls, and ovarian weights increased by one third. The ovaries contained multiple cystoidal follicles. Results of the study demonstrate the key role of ovarian steroid aromatase in letrozole-induced disorders of reproductive cycles. Letrozole might be recommended for experimental modeling of reproductive cycle disorders in female rats.
Tarasenko
L V
LV
Reznikov
O H
OH
D000284:Administration, Oral; D000780:Anestrus / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D001141:Aromatase / Q000378:metabolism / Q000502:physiology*; D047072:Aromatase Inhibitors / Q000494:pharmacology; D001835:Body Weight / Q000187:drug effects; D030762:Estrous Cycle / Q000187:drug effects*; D005260:Female; D007247:Infertility, Female / Q000139:chemically induced / Q000201:enzymology*; D000077289:Letrozole; D009570:Nitriles / Q000494:pharmacology; D009929:Organ Size / Q000187:drug effects; D010053:Ovary / Q000187:drug effects* / Q000201:enzymology; D051381:Rats; D017208:Rats, Wistar; D014230:Triazoles / Q000494:pharmacology
D047072:Aromatase Inhibitors; D009570:Nitriles; D014230:Triazoles; D000077289:Letrozole; D001141:Aromatase