title: Prostate and lymph node proton magnetic resonance (MR) spectroscopic imaging with external array coils at 3 T to detect recurrent prostate cancer after radiation therapy.
abstract: In a patient suspected of having recurrent prostate cancer after radiation therapy, we demonstrate the feasibility of noninvasive proton magnetic resonance spectroscopic (1H-MRS) imaging of the prostate and a lymph node at 3 T using a matrix of external surface coils. Written informed consent was obtained from the patient. With 1H-MRS imaging, high choline with low citrate signal was observed in the prostate, and in the lymph node a signal of choline-containing compounds was identified. The tissue level of the compounds in the enlarged lymph node was estimated to be 8.1 mmol/kg water. Subsequent histopathological analysis of systematic transrectal ultrasound-guided prostate biopsy and computed tomography-guided biopsy of the lymph node confirmed the presence of prostate cancer in both.
authors.affiliation: Department of Radiology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands. s.heijmink@rad.umcn.nl
authors.forename: Stijn W T P J
authors.initials: SW
authors.lastname: Heijmink
authors.forename: Tom W J
authors.initials: TW
authors.lastname: Scheenen
authors.forename: Jurgen J
authors.initials: JJ
authors.lastname: Fütterer
authors.forename: Dennis W J
authors.initials: DW
authors.lastname: Klomp
authors.forename: Roel A M
authors.initials: RA
authors.lastname: Heesakkers
authors.forename: Christina A
authors.initials: CA
authors.lastname: Hulsbergen-van de Kaa
authors.forename: Emile N J Th
authors.initials: EN
authors.lastname: van Lin
authors.forename: Arend
authors.initials: A
authors.lastname: Heerschap
authors.forename: Jelle O
authors.initials: JO
authors.lastname: Barentsz
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology* / Q000532:radiotherapy; D000368:Aged; D002794:Choline / Q000378:metabolism; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis / Q000473:pathology; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D009367:Neoplasm Staging; D011471:Prostatic Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000532:radiotherapy
chemical_list: D002794:Choline