title: Efficient one-pot synthesis of highly substituted pyridin-2(1H)-ones via the Vilsmeier-Haack reaction of 1-acetyl,1-carbamoyl cyclopropanes.
abstract: A facile and efficient one-pot synthesis of highly substituted pyridin-2(1H)-ones is developed via the Vilsmeier-Haack reaction of readily available 1-acetyl,1-carbamoyl cyclopropanes, and a mechanism involving sequential ring-opening, haloformylation, and intramolecular nucleophilic cyclization reactions is proposed.
authors.affiliation: Department of Chemistry, Northeast Normal University, Changchun 130024, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Pan
authors.forename: Dewen
authors.initials: D
authors.lastname: Dong
authors.forename: Kewei
authors.initials: K
authors.lastname: Wang
authors.forename: Jie
authors.initials: J
authors.lastname: Zhang
authors.forename: Rigenhada
authors.initials: R
authors.lastname: Wu
authors.forename: Dexuan
authors.initials: D
authors.lastname: Xiang
authors.forename: Qun
authors.initials: Q
authors.lastname: Liu
mesh_terms: D018360:Crystallography, X-Ray; D003521:Cyclopropanes / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D011728:Pyridones / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D003521:Cyclopropanes; D011728:Pyridones