title: Hepatocellular adenoma with malignant alteration.
abstract: Hepatocellular adenoma is a rare benign tumor of the liver which appears almost exclusively in women taking oral contraceptives. Malignant alteration of the tumor is very rare with about 12 reported cases. Case outline. We present a 70-year-old woman who had not taken either oral contraceptive or other hormones ever in her life and in whom an abdominal tumor was discovered during the regular check-up for arterial hypertension. With ultrasonography and CT scan a solitary well demarcated mass within the right liver of otherwise normal appearance was diagnosed. During an open surgery a solitary, unilobular, spherical, well demarcated tumor on the lower surface of the segments IVb, V and VI of the liver, 115 x 100 x 90 mm in diameter was excised. The histology revealed a hepatocellular adenoma with malignant alteration. The patient is the eldest presented case of malignant alteration of hepatocellular adenoma who had never taken oral contraceptives or other hormones.
authors.affiliation: Institute for Digestive Diseases, Clinical Center of Serbia, Belgrade, Serbia and Montenegro. marcolov@EUnet.yu
authors.forename: Radoje
authors.initials: R
authors.lastname: Colovic
authors.forename: Nikica
authors.initials: N
authors.lastname: Grubor
authors.forename: Marjan
authors.initials: M
authors.lastname: Micev
authors.forename: Vladimir
authors.initials: V
authors.lastname: Radak
mesh_terms: D018248:Adenoma, Liver Cell / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D000368:Aged; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D003937:Diagnosis, Differential; D005260:Female; D006498:Hepatectomy; D006801:Humans; D008099:Liver / Q000473:pathology; D008113:Liver Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D012307:Risk Factors; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography