No association in frequency of KIR receptors in patients with rheumatoid arthritis from Northern Ireland.
The frequency of inhibiting and activating killer cell immunoglobulin-like receptors was similar in 331 patients with rheumatoid arthritis and in 354 controls. Patients and controls came from a relatively homogeneous Caucasian population from Northern Ireland, thus limiting population stratification. Furthermore, no differences were found when the patients were sub-divided according to gender or shared epitope and when the presence of the human leucocyte antigen ligand was taken into account.
Middleton
D
D
Northern Ireland Histocompatibility and Immunogenetics Laboratory, City Hospital, Belfast, Northern Ireland. derek.middleton@bll.n-i.nhs.uk
Meenagh
A
A
Wright
G D
GD
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001172:Arthritis, Rheumatoid / Q000235:genetics*; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D005787:Gene Frequency; D006680:HLA Antigens / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D009660:Northern Ireland; D011971:Receptors, Immunologic / Q000235:genetics*; D054340:Receptors, KIR; D044465:White People / Q000235:genetics
D006680:HLA Antigens; D011971:Receptors, Immunologic; D054340:Receptors, KIR