PCR-restriction fragment length polymorphism analysis of Campylobacter jejuni genes involved in lipooligosaccharide biosynthesis identifies putative molecular markers for Guillain-Barré syndrome.
Molecular mimicry of Campylobacter jejuni lipooligosaccharides (LOS) by gangliosides in peripheral nerve tissue probably triggers the Guillain-Barré syndrome due to the induction of cross-reactive antibodies. PCR-restriction fragment length polymorphism analysis of C. jejuni genes involved in the biosynthesis of LOS demonstrated that specific genes were associated with the expression of ganglioside mimics and the development of neuropathy.
Godschalk
Peggy C R
PC
Department of Medical Microbiology and Infectious Diseases, Erasmus MC, Rotterdam, The Netherlands. p.godschalk@erasmusmc.nl
van Belkum
Alex
A
van den Braak
Nicole
N
van Netten
Diana
D
Ang
C Wim
CW
Jacobs
Bart C
BC
Gilbert
Michel
M
Endtz
Hubert P
HP
D000907:Antibodies, Bacterial / Q000276:immunology*; D015415:Biomarkers; D016123:Campylobacter jejuni / Q000235:genetics*; D003429:Cross Reactions; D015964:Gene Expression Regulation, Bacterial; D020275:Guillain-Barre Syndrome / Q000276:immunology*; D006801:Humans; D008070:Lipopolysaccharides / Q000096:biosynthesis* / Q000276:immunology; D018716:Molecular Mimicry; D016133:Polymerase Chain Reaction / Q000379:methods*; D012150:Polymorphism, Restriction Fragment Length
D000907:Antibodies, Bacterial; D015415:Biomarkers; D008070:Lipopolysaccharides; C023023:lipid-linked oligosaccharides