Diabetes induced by partial hepatic sensory denervation in conscious rabbits.
Exposure of the anterior hepatic plexus to 2% perineurial capsaicin solution over three days caused transient insulin resistance confirmed by hyperinsulinaemic euglycaemic glucose clamping. Three additional perineurial capsaicin treatments divided by 3-month intervals yielded diabetes characterized by an increase in fasting blood glucose and glycated haemoglobin levels. Both insulin sensitivity and glycated haemoglobin level re-normalized over an additional 6-month period. We conclude that chronic partial hepatic sensory denervation produces diabetes in rabbits.
Herczeg
László
L
Department of Forensic Medicine, University of Debrecen, H-4032 Debrecen, Nagyerdei krt 98, Hungary.
Buherenkova
Tatjana
T
Szilvássy
Zoltán
Z
Peitl
Barna
B
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D002211:Capsaicin / Q000494:pharmacology*; D003714:Denervation; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000209:etiology*; D006442:Glycated Hemoglobin / Q000378:metabolism; D007328:Insulin / Q000494:pharmacology; D007333:Insulin Resistance / Q000502:physiology*; D008099:Liver / Q000294:innervation* / Q000378:metabolism; D008297:Male; D011817:Rabbits
D001786:Blood Glucose; D002211:Capsaicin; D006442:Glycated Hemoglobin; D007328:Insulin