title: Insulin-like growth factor (IGF)-I and insulin in normal and growth-restricted mother/infant pairs.
abstract: Insulin-like growth factor (IGF)-I and insulin are essential for fetal growth. We investigated perinatal changes of both factors in 40 mothers and their 20 appropriate-for-gestational-age (AGA) and 20 intrauterine-growth-restricted (IUGR) fetuses and neonates on day 1 (N1) and day 4 (N4) postpartum. Fetal and N1, but not N4, IGF-I levels were increased in AGA (P < .001 and P = .037, resp.). N1 insulin levels were lower in IUGR (P = .048). Maternal, fetal, and N1 IGF-I, and fetal insulin levels positively correlated with customized centiles (r = .374, P = .035, r = .608, P < .001, r = .485, P = .006, and r = .654, P = .021, resp.). Female infants presented elevated fetal and N4 IGF-I levels (P = .023 and P = .016, resp.). Positive correlations of maternal, fetal, and neonatal IGF-I levels, and fetal insulin levels with customized centiles underline implication of both hormones in fetal growth. IUGR infants present gradually increasing IGF-I levels. Higher IGF-I levels are documented in females.
authors.affiliation: Neonatal Division, Second Department of Obstetrics and Gynecology, Athens University Medical School, 10682 Athens, Greece.
authors.forename: Ariadne
authors.initials: A
authors.lastname: Malamitsi-Puchner
authors.forename: Despina D
authors.initials: DD
authors.lastname: Briana
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Gourgiotis
authors.forename: Maria
authors.initials: M
authors.lastname: Boutsikou
authors.forename: Karl-Philipp
authors.initials: KP
authors.lastname: Puchner
authors.forename: Stavroula
authors.initials: S
authors.lastname: Baka
authors.forename: Antonios
authors.initials: A
authors.lastname: Marmarinos
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Hassiakos
mesh_terms: D000328:Adult; D005260:Female; D005317:Fetal Growth Retardation / Q000097:blood / Q000378:metabolism*; D005333:Fetus / Q000378:metabolism; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007328:Insulin / Q000097:blood / Q000378:metabolism*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D008297:Male; D011247:Pregnancy; D013997:Time Factors
chemical_list: D007328:Insulin; D007334:Insulin-Like Growth Factor I