Interaction characteristics and thermodynamic behaviour of gatifloxacin by aluminium hydroxide.
The interaction pattern of gatifloxacin was temperature-dependent Langmuir isotherm, and the Langmuir coefficients increased as the temperature was raised. The perturbation experiment conducted on this system showed that the nature of interaction was irreversible. The enthalpy change is a positive value, indicating the existence of increased activation energy as the temperature is raised. The entropy value, 24.21 e.u. obtained in this system, indicated that the hydration shells of the ions were rather tightly bound. Intestinal permeation study also revealed the decreased bioavailability of gatifloxacin relatively to the presence of aluminium hydroxide. The strong adsorption of gatifloxacin by aluminium hydroxide is due to formation of complexes with cations of aluminium hydroxide through carboxyl and carbonyl groups of gatifloxacin.
Mallick
Subrata
S
Formulation Development and Drug Delivery Systems, Department of Pharmaceutics, College of Pharmaceutical Sciences, Mohuda, Berhampur, Orissa, India. smallickin@yahoo.co.in
Pattnaik
Satyanarayan
S
Swain
Kalpana
K
De
Pintu K
PK
Mondal
Arijit
A
Ghoshal
Gourisankar
G
Saha
Arindam
A
D000327:Adsorption; D000536:Aluminum Hydroxide / Q000737:chemistry*; D000818:Animals; D000863:Antacids / Q000737:chemistry*; D000890:Anti-Infective Agents / Q000737:chemistry / Q000493:pharmacokinetics*; D001682:Biological Availability; D002412:Cations; D004347:Drug Interactions; D024841:Fluoroquinolones / Q000737:chemistry / Q000493:pharmacokinetics*; D000077734:Gatifloxacin; D006041:Goats; D007408:Intestinal Absorption; D007700:Kinetics; D010539:Permeability; D013696:Temperature; D013816:Thermodynamics
D000863:Antacids; D000890:Anti-Infective Agents; D002412:Cations; D024841:Fluoroquinolones; D000536:Aluminum Hydroxide; D000077734:Gatifloxacin