Analgesic and antipyretic effects of Capparis zeylanica leaves.
The ethanol and water extracts of Capparis zeylanica leaves showed dose-dependent and significant (P<0.05) increases in pain threshold in tail-immersion test. Moreover, both the extracts (100-200 mg/kg) exhibited a dose-dependent inhibition of writhing and also showed a significant (P<0.001) inhibition of both phases of the formalin pain test. The water extract (200 mg/kg) significantly (P<0.01) reversed yeast-induced fever. Preliminary phytochemical screening of the extracts showed the presence of alkaloids, flavonoids, saponins glycosides, terpenoids, tannins, proteins and carbohydrates.
Ghule
B V
BV
Institute of Pharmaceutical Education and Research, Borgaon, Wardha, MS, India. dr_yeole@rediffmail.com
Murugananthan
G
G
Yeole
P G
PG
D000700:Analgesics / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D031484:Capparis; D004305:Dose-Response Relationship, Drug; D005260:Female; D005557:Formaldehyde; D008297:Male; D051379:Mice; D010146:Pain / Q000139:chemically induced / Q000517:prevention & control*; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves; D051381:Rats; D017208:Rats, Wistar
D000700:Analgesics; D018712:Analgesics, Non-Narcotic; D010936:Plant Extracts; D005557:Formaldehyde