The DEAD-box p68/p72 proteins and the noncoding RNA steroid receptor activator SRA: eclectic regulators of disparate biological functions.
p68 and p72 are RNA-binding proteins endowed with RNA helicase and RNA-protein complex remodeling activities. One of the RNAs associated with p68/p72 is the noncoding Steroid Receptors RNA Activator (SRA). Here we review recent findings on the cellular processes regulated by either p68/p72 alone or in combination with SRA and discuss the transcriptional events influenced by these molecules.
Caretti
Giuseppina
G
Laboratory of Muscle Stem Cells and Gene Regulation, NIAMS, National Institutes of Health, Bethesda, Maryland 20892, USA.
Lei
Elissa P
EP
Sartorelli
Vittorio
V
D002453:Cell Cycle / Q000502:physiology*; D053487:DEAD-box RNA Helicases / Q000378:metabolism*; D005786:Gene Expression Regulation; D008954:Models, Biological; D062085:RNA, Long Noncoding; D022661:RNA, Untranslated / Q000378:metabolism*; D050436:Regulatory Elements, Transcriptional / Q000502:physiology*
D062085:RNA, Long Noncoding; D022661:RNA, Untranslated; C405423:steroid receptor RNA activator; C102004:DDX17 protein, human; D053487:DEAD-box RNA Helicases