title: Liver X receptor antagonists with a phthalimide skeleton derived from thalidomide-related glucosidase inhibitors.
abstract: Alpha-glucosidase inhibitors with a chlorinated phthalimide or a thiophthalimide skeleton, derived from thalidomide, were found to possess liver X receptor (LXR) antagonistic activity. Novel LXR antagonists with a 2'-substituted phenylphthalimide skeleton were obtained by structural development of glucosidase inhibitors derived from thalidomide.
authors.affiliation: Institute of Molecular and Cellular Biosciences, University of Tokyo, 1-1-1 Yayoi, Tokyo 113-0032, Japan.
authors.forename: Tomomi
authors.initials: T
authors.lastname: Noguchi-Yachide
authors.forename: Atsushi
authors.initials: A
authors.lastname: Aoyama
authors.forename: Makoto
authors.initials: M
authors.lastname: Makishima
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Miyachi
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Hashimoto
mesh_terms: D002460:Cell Line; D004268:DNA-Binding Proteins / Q000037:antagonists & inhibitors*; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D005959:Glucosidases / Q000037:antagonists & inhibitors*; D006801:Humans; D000071518:Liver X Receptors; D015394:Molecular Structure; D057093:Orphan Nuclear Receptors; D010797:Phthalimides / Q000737:chemistry*; D018160:Receptors, Cytoplasmic and Nuclear / Q000037:antagonists & inhibitors*; D013792:Thalidomide / Q000737:chemistry*
chemical_list: D004268:DNA-Binding Proteins; D004791:Enzyme Inhibitors; D000071518:Liver X Receptors; D057093:Orphan Nuclear Receptors; D010797:Phthalimides; D018160:Receptors, Cytoplasmic and Nuclear; D013792:Thalidomide; D005959:Glucosidases