title: The first sequential reaction promoted by manganese: complete stereoselective synthesis of (E)-alpha,beta-unsaturated esters from 2,2-dichloroesters and aldehydes.
abstract: Alpha,beta-unsaturated esters were obtained with complete control of stereoselectivity utilizing a sequential reaction of dichloroesters with a variety of aldehydes, promoted by active manganese. This methodology is generally applicable, and the C-C double bond can be di- or trisubstituted. A mechanism based on a successive aldol-type reaction/beta-elimination is proposed to explain these results.
authors.affiliation: Departamento de Química Orgánica e Inorgánica, Facultad de Química, Universidad de Oviedo, Julián Clavería 8, 33071 Oviedo, Spain. jmcg@uniovi.es
authors.forename: José M
authors.initials: JM
authors.lastname: Concellón
authors.forename: Humberto
authors.initials: H
authors.lastname: Rodríguez-Solla
authors.forename: Pamela
authors.initials: P
authors.lastname: Díaz
authors.forename: Ricardo
authors.initials: R
authors.lastname: Llavona