title: Synthesis and antimicrobial studies of novel dichlorofluorophenyl containing aminotriazolothiadiazines.
abstract: Dichlorofluorophenyl containing aminotriazolothiadiazines (6) were synthesized by initial condensation of 2-chloro-N-(substituted phenyl) acetamides (4) with triazole (3) and further cyclization using POCl(3). The structures of newly synthesized compounds were confirmed by IR, NMR, mass and elemental analysis. All the compounds were screened for their antibacterial and antifungal activities. Compounds 5a, 5e, 5n, 5o, 6a, 6n, and 6o showed very good antibacterial and antifungal activities at 6.25 microg/ml concentrations.
authors.affiliation: Department of Chemistry, Mangalore University, Mangalagangothri 574199, India. karthims02@rediffmail.com
authors.forename: Mari Sithambaram
authors.initials: MS
authors.lastname: Karthikeyan
authors.forename: Bantwal Shivarama
authors.initials: BS
authors.lastname: Holla
authors.forename: Nalilu Suchetha
authors.initials: NS
authors.lastname: Kumari
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013055:Spectrophotometry, Infrared; D013843:Thiazines / Q000138:chemical synthesis* / Q000494:pharmacology*; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D013843:Thiazines; D013844:Thiazoles