Prism adaptation in spinocerebellar ataxia type 2.
Patients with spinocerebellar ataxia type 2 (SCA2), develop severe pontine nuclei, inferior olives, and Purkinje cell degeneration. This form of autosomal dominant cerebellar ataxia is accompanied by progressive ataxia and dysarthria. Although the motor dysfunction is well characterized in these patients, nothing is known about their motor learning capabilities. Here we tested 43 SCA2 patients and their matched controls in prism adaptation, a kind of visuomotor learning task. Our results show that their pattern of brain damage does not entirely disrupt motor learning. Rather, patients had impaired adaptation decrement, but surprisingly a normal aftereffect. Moreover, the mutation degree could discriminate the degree of adaptation. This pattern could reflect the net contribution of two adaptive mechanisms: strategic control and spatial realignment. Accordingly, SCA2 patients show an impaired strategic control that affects the adaptation rate, but a normal spatial realignment measured through the aftereffect. Our results suggest that the neural areas subserving spatial realignment are spared in this form of spinocerebellar ataxia.
Fernandez-Ruiz
Juan
J
Laboratorio de Neuropsicología, Departamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico. jfr@servidor.unam.mx
Velásquez-Perez
Luis
L
Díaz
Rosalinda
R
Drucker-Colín
René
R
Pérez-González
Ruth
R
Canales
Nalia
N
Sánchez-Cruz
Gilberto
G
Martínez-Góngora
Edilberto
E
Medrano
Yaquelín
Y
Almaguer-Mederos
Luis
L
Seifried
Carola
C
Auburger
Georg
G
D000222:Adaptation, Physiological / Q000502:physiology*; D000293:Adolescent; D000328:Adult; D000368:Aged; D004584:Electronystagmography; D005260:Female; D005366:Figural Aftereffect / Q000502:physiology; D006801:Humans; D007858:Learning / Q000502:physiology; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D011597:Psychomotor Performance / Q000502:physiology; D012438:Saccades / Q000502:physiology; D020754:Spinocerebellar Ataxias / Q000145:classification / Q000503:physiopathology*