title: Relationship of serum adiponectin with blood lipids, HbA(1)c, and hs-CRP in type II diabetic postmenopausal women.
abstract: Adipose tissue has been considered an important endocrine organ. Adiponectin secretes from adipose tissue and plays an important role in the regulation of glycemia, beta-oxidation in muscle, and decreased insulin resistance in the liver. The objectives of this study were to compare the levels of adiponectin, hs-C-reactive protein (CRP), HbA1c, and blood lipids among diabetic and healthy postmenopausal women, and to determine the relationship between circulating adiponectin and development of type II diabetes. This case-control study was performed on 28 diabetic and 42 age-matched healthy women. All participants were postmenopausal. Serum adiponectin concentrations, serum triglycerides (TG), cholesterol, low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) concentrations were determined. Blood HbA1c and serum hs-CRP were also measured. Adiponectin levels were significantly decreased (P<0.01) in the diabetic patients as compared to normal control subjects. Adiponectin levels were negatively associated with hs-CRP, LDL-C, HbA1c, TG, and total cholesterol (TC). A positive correlation was observed between adiponectin and HDL-C. The obtained data indicate that diabetic women have lower adiponectin levels compared to healthy women. HbA1c as an indicator of glycemic control has a negative correlation with serum adiponectin. Adiponectin may play an important role in the pathogenesis of diabetes, and may be an independent predictor of the development of diabetes in women.
authors.affiliation: Department of Biochemistry and Nutrition, Medical School, Hamadan University of Medical Sciences, Hamadan, Iran. mtgoodarzi@yahoo.com
authors.forename: Mohammad Taghi
authors.initials: MT
authors.lastname: Goodarzi
authors.forename: Hossein
authors.initials: H
authors.lastname: Babaahmadi-Rezaei
authors.forename: Manizheh
authors.initials: M
authors.lastname: Kadkhodaei-Eliaderani
authors.forename: Shahram
authors.initials: S
authors.lastname: Haddadinezhad
mesh_terms: D052242:Adiponectin / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D005260:Female; D006442:Glycated Hemoglobin; D006454:Hemoglobins / Q000032:analysis*; D006801:Humans; D008055:Lipids / Q000097:blood*; D008875:Middle Aged; D017698:Postmenopause; D011237:Predictive Value of Tests
chemical_list: D052242:Adiponectin; D015415:Biomarkers; D002097:C-Reactive Protein; D006442:Glycated Hemoglobin; D006454:Hemoglobins; D008055:Lipids; C517652:hemoglobin A1c protein, human