Photodynamic activity of water-soluble phthalocyanine zinc(II) complexes against pathogenic microorganisms.
Photodynamic activity of tetrakis-(3-methylpyridyloxy)- and tetrakis-(4-sulfophenoxy)-phthalocyanine zinc(II) toward the gram-positive Staphylococcus aureus, the gram-negative Pseudomonas aeruginosa, and the fungi Candida albicans was studied. The drug uptake dependency with an inverse behavior to the cell density was observed. The cationic photosensitizer completely inactivated S. aureus and C. albicans, and with 4 log10 P. aeruginosa. The photoinactivation at mild experimental conditions, such as drug dose of 1.5 microM and fluence of 50 mW cm(-2) for 10 min irradiation time, was shown.
Mantareva
Vanya
V
Institute of Organic Chemistry, Bulgarian Academy of Sciences, Acad. G. Bonchev str, Bl. 9, 1113 Sofia, Bulgaria. mantareva@yahoo.com
Kussovski
Veselin
V
Angelov
Ivan
I
Borisova
Ekaterina
E
Avramov
Latchezar
L
Schnurpfeil
Günter
G
Wöhrle
Dieter
D
D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects / Q000472:pathogenicity / Q000528:radiation effects; D007211:Indoles / Q000737:chemistry* / Q000494:pharmacology*; D054833:Isoindoles; D050296:Microbial Viability / Q000187:drug effects / Q000528:radiation effects; D015394:Molecular Structure; D017319:Photosensitizing Agents / Q000737:chemistry* / Q000494:pharmacology*; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000472:pathogenicity / Q000528:radiation effects; D012995:Solubility; D013211:Staphylococcus aureus / Q000187:drug effects / Q000472:pathogenicity / Q000528:radiation effects; D014867:Water / Q000737:chemistry*; D015032:Zinc / Q000737:chemistry*
D000890:Anti-Infective Agents; D007211:Indoles; D054833:Isoindoles; D017319:Photosensitizing Agents; D014867:Water; D015032:Zinc; C013647:phthalocyanine