title: Trends in risk factors, patterns and causes in hospitalized strokes over 25 years: The Lausanne Stroke Registry.
abstract: OBJECTIVE
  The Lausanne Stroke Registry includes, from 1979, all patients admitted to the department of Neurology of the Lausanne University Hospital with the diagnosis of first clinical stroke. Using the Lausanne Stroke Registry, we aimed to determine trends in risk factors, causes, localization and inhospital mortality over 25 years in hospitalized stroke patients.
  
  
  METHODS
  We assessed temporal trends in stroke patients characteristics through the following consecutive periods: 1979-1987, 1988-1995 and 1996-2003. Age-adjusted cardiovascular risk factors, etiologies, stroke localizations and mortality were compared between the three periods.
  
  
  RESULTS
  Overall, 5,759 patients were included. Age was significantly different among the analyzed periods (p < 0.001), showing an increment in older patients throughout time. After adjustment for age, hypercholesterolemia increased (p < 0.001), as opposed to cigarette smoking (p < 0.001), hypertension (p < 0.001) and diabetes and hyperglycemia (p < 0.001). In patients with ischemic strokes, there were significant changes in the distribution of causes with an increase in cardioembolic strokes (p < 0.001), and in the localization of strokes with an increase in entire middle cerebral artery (MCA) and posterior circulation strokes together with a decrease in superficial middle cerebral artery stroke (p < 0.001). In patients with hemorrhagic strokes, the thalamic localizations increased, whereas the proportion of striatocapsular hemorrhage decreased (p = 0.022). Except in the older patient group, the mortality rate decreased.
  
  
  CONCLUSIONS
  This study shows major trends in the characteristics of stroke patients admitted to a department of neurology over a 25-year time span, which may result from referral biases, development of acute stroke management and possibly from the evolution of cerebrovascular risk factors.
authors.affiliation: Department of Neurology, University Hospital Lausanne, Lausanne, Switzerland. emmanuel.carrera@chuv.ch
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Carrera
authors.forename: Malin
authors.initials: M
authors.lastname: Maeder-Ingvar
authors.forename: Andrea O
authors.initials: AO
authors.lastname: Rossetti
authors.forename: Gérald
authors.initials: G
authors.lastname: Devuyst
authors.forename: Julien
authors.initials: J
authors.lastname: Bogousslavsky
mesh_terms: D000328:Adult; D017677:Age Distribution; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002545:Brain Ischemia / Q000150:complications / Q000453:epidemiology; D048909:Diabetes Complications / Q000209:etiology / Q000401:mortality; D005260:Female; D017052:Hospital Mortality / Q000639:trends; D006760:Hospitalization / Q000706:statistics & numerical data; D006785:Hospitals, University / Q000706:statistics & numerical data*; D006801:Humans; D006937:Hypercholesterolemia / Q000150:complications / Q000453:epidemiology; D006943:Hyperglycemia / Q000150:complications / Q000453:epidemiology; D006973:Hypertension / Q000150:complications / Q000453:epidemiology; D020300:Intracranial Hemorrhages / Q000150:complications / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012042:Registries / Q000706:statistics & numerical data*; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D020521:Stroke / Q000209:etiology* / Q000401:mortality* / Q000628:therapy; D013557:Switzerland / Q000453:epidemiology; D013997:Time Factors