Pharmacological modulation of wound healing in experimental burns.
Factors involved in wound healing and their interdependence are not yet fully understood; nevertheless, new prospects for therapy to favor speedy and optimal healing are emerging. Reports about wound healing modulation by local application of simple and natural agents abound even in the recent literature, however, most are anecdotal and lack solid scientific evidence. We describe the effect of silver sulfadiazine and moist exposed burn ointment (MEBO), a recently described burn ointment of herbal origin, on mast cells and several wound healing cytokines (bFGF, IL-1, TGF-beta, and NGF) in the rabbit experimental burn model. The results demonstrate that various inflammatory cells, growth factors and cytokines present in the wound bed may be modulated by application of local agents with drastic effects on their expression dynamics with characteristic temporal and spatial regulation and changes in the expression pattern. Such data are likely to be important for the development of novel strategies for wound healing since they shed some light on the potential formulations of temporally and combinatory optimized therapeutic regimens.
Jurjus
Abdo
A
Human Morphology, Faculty of Medicine, American University of Beirut Medical Center, Beirut, Lebanon.
Atiyeh
Bishara S
BS
Abdallah
Inaya M
IM
Jurjus
Rosalyne A
RA
Hayek
Shady N
SN
Jaoude
Marlene Abou
MA
Gerges
Alice
A
Tohme
Rania A
RA
D000818:Animals; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use*; D002056:Burns / Q000188:drug therapy* / Q000473:pathology; D016207:Cytokines / Q000378:metabolism; D004797:Enzyme-Linked Immunosorbent Assay; D008407:Mast Cells / Q000473:pathology; D009824:Ointments; D011817:Rabbits; D012837:Silver Sulfadiazine / Q000627:therapeutic use*; D012855:Sitosterols / Q000627:therapeutic use*; D014870:Water Loss, Insensible / Q000187:drug effects; D014945:Wound Healing / Q000187:drug effects*; D014946:Wound Infection / Q000517:prevention & control*
D000891:Anti-Infective Agents, Local; D016207:Cytokines; D009824:Ointments; D012855:Sitosterols; C472006:moist exposed burn ointment; D012837:Silver Sulfadiazine