title: [Histopathological changes in livers of patients with chronic severe hepatitis B].
abstract: OBJECTIVE
  To investigate the histopathological features in livers of chronic severe hepatitis B (CSHB) patients.
  
  
  METHODS
  Histology of 42 livers was studied. HE, Masson, Sweet and D-PAS staining and cytokeratin 7, CD68 and proliferating cell nuclear antigen immuno-histochemical staining were used in the study.
  
  
  RESULTS
  In CSHB, the livers showed massive or submassive necrosis in a background of other histological changes of chronic hepatitis B. The characteristic pictures of these livers were necrosis of all the hepatocytes in some nodules, while in other nodules there were only patchy necroses of the parenchyma. In some other nodules the necrotic hepatocytes were all removed and only the scaffolding stroma remained. Meanwhile, regeneration of hepatocytes and bile ductules were also seen.
  
  
  CONCLUSIONS
  The liver histopathological changes in CSHB are identical, but not of the same degree as those of acute severe and subacute severe hepatitis B. In making differential diagnoses for liver aspiration biopsies of these patients, this fact should be kept in mind.
authors.affiliation: Department of Pathology, Beijing You'an Hospital, Affiliated to Capital University of Medicine, Beijing 100069, China.
authors.forename: Li-jie
authors.initials: LJ
authors.lastname: Zhang
authors.forename: Tai-ling
authors.initials: TL
authors.lastname: Wang
authors.forename: Xu-hua
authors.initials: XH
authors.lastname: Liu
authors.forename: Ke-jia
authors.initials: KJ
authors.lastname: Zu
authors.forename: Xin
authors.initials: X
authors.lastname: Meng
authors.forename: Yue
authors.initials: Y
authors.lastname: Wang
authors.forename: Zhong-ping
authors.initials: ZP
authors.lastname: Duan
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D019694:Hepatitis B, Chronic / Q000175:diagnosis / Q000473:pathology*; D006801:Humans; D008099:Liver / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D013194:Staining and Labeling; D055815:Young Adult