Placental ischemia and soluble fms-like tyrosine kinase 1: cause or consequence of preeclampsia?
Elevated circulating soluble fms-like tyrosine kinase 1 (sFLT-1) is associated with the development of the clinical signs and symptoms of preeclampsia. Placental ischemia has been suggested as one of the etiological factors that mediate increased sFLT-1 production in patients with preeclampsia, but definitive evidence for this hypothesis was lacking. Makris et al. demonstrate that inducing placental ischemia in primates is sufficient to induce sFLT-1 upregulation and the clinical signs and symptoms of preeclampsia.
Karumanchi
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SA
Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA. sananth@bidmc.harvard.edu
Epstein
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FH
D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D007511:Ischemia / Q000150:complications* / Q000201:enzymology*; D010920:Placenta / Q000098:blood supply*; D011225:Pre-Eclampsia / Q000209:etiology*; D011247:Pregnancy; D040281:Vascular Endothelial Growth Factor Receptor-1 / Q000378:metabolism*
D040281:Vascular Endothelial Growth Factor Receptor-1