title: Alteration of beta-secretase traffic by the receptor tyrosine kinase signaling pathway - a new mechanism for regulating Alzheimer's beta-amyloid production.
authors.affiliation: Center for Neuroscience and Aging, Burnham Institute for Medical Research, 10901 N. Torrey Pines Rd., La Jolla, CA 92037, USA.
authors.forename: Yun-Wu
authors.initials: YW
authors.lastname: Zhang
authors.forename: Huaxi
authors.initials: H
authors.lastname: Xu
mesh_terms: D000544:Alzheimer Disease / Q000503:physiopathology; D053829:Amyloid Precursor Protein Secretases / Q000378:metabolism*; D016229:Amyloid beta-Peptides / Q000096:biosynthesis*; D000818:Animals; D016282:Aspartic Acid Endopeptidases / Q000378:metabolism*; D004789:Enzyme Activation; D004815:Epidermal Growth Factor / Q000502:physiology; D006801:Humans; D051379:Mice; D020932:Nerve Growth Factor / Q000502:physiology; D020794:Receptor Protein-Tyrosine Kinases / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D021601:trans-Golgi Network / Q000502:physiology
chemical_list: D016229:Amyloid beta-Peptides; D004815:Epidermal Growth Factor; D020932:Nerve Growth Factor; D020794:Receptor Protein-Tyrosine Kinases; D053829:Amyloid Precursor Protein Secretases; D016282:Aspartic Acid Endopeptidases; C509282:Bace1 protein, mouse