Early fetal healing as a model for adult organ regeneration.
Evidence is provided pointing out certain basic similarities, though not an identity, between the mechanisms of early fetal regeneration and induced organ regeneration in adults. These similarities favor a model of induced organ regeneration in which biologically active scaffolds block wound contraction and scar formation.
Yannas
Ioannis V
IV
Department of Mechanical Engineering, Materials Science Engineering, and Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA. yannas@mit.edu
Kwan
Matthew D
MD
Longaker
Michael T
MT
D000328:Adult; D000818:Animals; D005333:Fetus / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D012038:Regeneration / Q000502:physiology*; D014945:Wound Healing / Q000502:physiology*