title: Soluble P selectin levels in chronic liver disease: relationship to disease severity.
abstract: OBJECTIVE
  Thrombocytopenia and platelet function abnormalities are problems commonly found in patients with chronic liver disease (CLD). Despite lack of widespread recognition as to the clinical significance of Soluble P-selectin (sP-selectin), in that increased levels of sP-selectin have been described in patients with CLD, it has been proposed as a marker of in-vivo platelet activation. The study's aim was to determine whether levels of sP-selectin in patients with CLD increase in accordance with the degree of liver failure, the likelihood of CLD patients with high sP-selectin levels being more prone to thrombosis, as well as investigating the coagulation and fibrinolytic parameters related to the sP-selectin.
  
  
  METHODS
  This study was comprised of two groups: 40 patients with cirrhosis and portal hypertension (28 males and 12 females); and a control group of 10 healthy volunteers (6 males and 4 females). In both groups, biochemical parameters, sP-selectin, coagulation and fibrinolytic activity levels were measured and a Doppler ultrasound was performed.
  
  
  RESULTS
  Plasma sP-selectin levels were found to be higher in the patients compared to those of the control group (p < 0.01), while at the same time significant differences were observed with respect to the stage of disease. Patients with low platelet counts were found to have higher sP-selectin levels than those with normal platelet counts (p < 0.01). Seven patients (17.5%) were seen to have portal vein thrombosis upon doppler ultrasound examination, while sP-selectin levels were significantly lower in those patients with thrombosis than those without (p < 0.05). It was our finding that sP-selectin levels inversely correlated with anti thrombin III.
  
  
  CONCLUSIONS
  In conclusion, sP-selectin levels related to the degree of liver disease and thrombosis are seen together with low platelet and sP-selectin levels in patients with cirrhosis.
authors.affiliation: Osmangazi University, Medical Faculty, Department of Gastroenterology, Eskisehir, Turkey. eservardareli@yahoo.com
authors.forename: Eser
authors.initials: E
authors.lastname: Vardareli
authors.forename: Tülay
authors.initials: T
authors.lastname: Saricam
authors.forename: Canan
authors.initials: C
authors.lastname: Demirustu
authors.forename: Zafer
authors.initials: Z
authors.lastname: Gulbas
mesh_terms: D001780:Blood Coagulation Tests; D005260:Female; D005342:Fibrinolysis / Q000502:physiology; D019694:Hepatitis B, Chronic / Q000097:blood / Q000175:diagnosis; D019698:Hepatitis C, Chronic / Q000175:diagnosis; D006801:Humans; D006975:Hypertension, Portal / Q000097:blood* / Q000175:diagnosis; D008103:Liver Cirrhosis / Q000097:blood* / Q000175:diagnosis; D017093:Liver Failure / Q000097:blood* / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D019007:P-Selectin / Q000097:blood*; D015539:Platelet Activation / Q000502:physiology; D019851:Thrombophilia / Q000097:blood / Q000175:diagnosis
chemical_list: D019007:P-Selectin