Cytotoxic cardenolides from Streptocaulon griffithii.
A new cardenolide, 3-O-(beta-glucopyranosyl)acovenosigenin A (1), was isolated from the roots of Streptocaulon griffithii, together with eight known cardenolides, compounds 2-9. All compounds showed significant in vitro inhibition of the proliferation of the human gastrointestinal cancer cell line HGC-27, with IC50 values in the range of ca. 20-564 nM, taxol being used as positive control. Compound 1 was also found to be strongly cytotoxic against other human tumor cell lines, including A549, MCF-7, and Hela cells.
Zhang
Xiao-Hui
XH
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institute for Biological Sciences, Chinese Academy of Science, 555 Zuchongzhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, PR China.
Zhu
Hui-Lin
HL
Yu
Qiang
Q
Xuan
Li-Jiang
LJ
D000970:Antineoplastic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D029062:Apocynaceae / Q000737:chemistry*; D002298:Cardenolides / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor / Q000187:drug effects / Q000502:physiology; D049109:Cell Proliferation / Q000187:drug effects*; D006367:HeLa Cells; D006801:Humans
D000970:Antineoplastic Agents; D002298:Cardenolides