Vascular endothelial growth factor and basic fibroblast growth factor in exudative age-related macular degeneration and diffuse diabetic macular edema.
BACKGROUND
To evaluate the concentrations of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) in neovascular or edematous retinal diseases.


METHODS
In the clinical comparative interventional study, VEGF and bFGF concentrations in aqueous humor samples of 35 patients with exudative age-related macular degeneration (AMD), 21 patients with diabetic macular edema and 24 patients of a control group were measured using a solid-phase chemiluminescence immunoassay.


RESULTS
Concentrations of VEGF and bFGF, respectively, were significantly higher in the diabetic group (184.7 +/- 107.0 and 5.0 +/- 10.2 pg/l) than in the AMD group (107.7 +/- 73.0 pg/l, p = 0.002; 2.2 +/- 7.4 pg/l, p = 0.002) and the control group (71.5 +/- 94.7 pg/l, p = 0.001; 0.00 pg/l, p = 0.001). The two latter groups did not vary significantly (p = 0.10).


CONCLUSIONS
VEGF and bFGF are present in considerably higher concentrations in eyes with diabetic macular edema than in eyes with exudative AMD or normal eyes. The differences were more marked for VEGF than for bFGF.
Jonas
Jost B
JB
Department of Ophthalmology, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Mannheim, Germany.
Neumaier
Michael
M
D000368:Aged; D000369:Aged, 80 and over; D001082:Aqueous Humor / Q000378:metabolism*; D015415:Biomarkers / Q000378:metabolism; D003930:Diabetic Retinopathy / Q000150:complications* / Q000378:metabolism; D005122:Exudates and Transudates; D016222:Fibroblast Growth Factor 2 / Q000378:metabolism*; D005500:Follow-Up Studies; D006801:Humans; D007118:Immunoassay; D008163:Luminescent Measurements; D008268:Macular Degeneration / Q000378:metabolism*; D008269:Macular Edema / Q000209:etiology / Q000378:metabolism*; D008875:Middle Aged; D011379:Prognosis; D012720:Severity of Illness Index; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*
D015415:Biomarkers; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D016222:Fibroblast Growth Factor 2