title: Comparison of acellular dermal matrix and synthetic mesh for lateral chest wall reconstruction in a rabbit model.
abstract: BACKGROUND
  Synthetic mesh is used for chest wall reconstruction, but infection or exposure can occur and necessitate removal. Human acellular dermal matrix (AlloDerm) has been used to reconstruct musculofascial defects in the trunk with low infection and herniation rates. AlloDerm may have advantages over synthetic mesh for chest wall reconstruction. This study compared outcomes and repair strengths of AlloDerm to expanded polytetrafluoroethylene mesh used for repair of rib cage defects.
  
  
  METHODS
  A 3 x 3-cm, full-thickness, lateral rib cage defect was created in each rabbit and repaired with expanded polytetrafluoroethylene (n = 8) or acellular dermal matrix (n = 9). At 4 weeks, the animals were euthanized and evaluated for lung herniation/dehiscence, strength of adhesions between the implant and intrapleural structures, and breaking strength of the implant materials and the implant-fascia interface. Tissue sections were analyzed with histologic and immunohistochemical staining to evaluate cellular infiltration and vascularization.
  
  
  RESULTS
  No herniation or dehiscence occurred with either material. The incidence and strength of adhesions was similar between materials. The mean breaking strength of the AlloDerm-fascia interface (14.5 +/- 8.9 N) was greater than the expanded polytetrafluoroethylene-fascia interface (8.7 +/- 4.4 N; p = 0.027) and similar to the rib-intercostal-rib interface of the contralateral native chest wall (14.0 +/- 5.6 N). The AlloDerm grafts became infiltrated with cells and vascularized after implantation.
  
  
  CONCLUSIONS
  AlloDerm used for chest wall reconstruction results in greater implant-defect interface strength than expanded polytetrafluoroethylene. The ability of AlloDerm to become vascularized and remodeled by autologous cells and to resist infection may be advantageous for chest wall reconstruction.
authors.affiliation: Baltimore, Md.; and Houston, Texas From the Divisions of Plastic and Reconstructive Surgery and Cardiothoracic Surgery, University of Maryland Medical Center, and Department of Plastic Surgery, The University of Texas M. D. Anderson Cancer Center.
authors.forename: Luther H
authors.initials: LH
authors.lastname: Holton
authors.forename: Thomas
authors.initials: T
authors.lastname: Chung
authors.forename: Ronald P
authors.initials: RP
authors.lastname: Silverman
authors.forename: Hafez
authors.initials: H
authors.lastname: Haerian
authors.forename: Nelson H
authors.initials: NH
authors.lastname: Goldberg
authors.forename: Whitney M
authors.initials: WM
authors.lastname: Burrows
authors.forename: Andrea
authors.initials: A
authors.lastname: Gobin
authors.forename: Charles E
authors.initials: CE
authors.lastname: Butler
mesh_terms: D000818:Animals; D003094:Collagen / Q000627:therapeutic use*; D004195:Disease Models, Animal; D008297:Male; D011138:Polytetrafluoroethylene; D011817:Rabbits; D019651:Plastic Surgery Procedures / Q000379:methods*; D012307:Risk Factors; D012680:Sensitivity and Specificity; D013526:Surgical Mesh; D013718:Tensile Strength; D013898:Thoracic Injuries / Q000601:surgery; D035441:Thoracic Wall / Q000601:surgery*; D014945:Wound Healing / Q000502:physiology
chemical_list: C440568:Alloderm; D011138:Polytetrafluoroethylene; D003094:Collagen