title: Curcumin and cyclopalladated complexes: a recipe for bifunctional biomaterials.
abstract: The first examples of binuclear and mononuclear ortho-palladated complexes based on a functionalized 2-phenylquinoline ligand have been synthesized and fully characterized. Conjugating cyclopalladated fragments to curcumin family biologically active beta-diketones gives in one single molecule two different functionalities. The structural variations based on the curcuminoid structure have been tested for their in vitro cytotoxic activity. The activity of complexes comprised of a cyclopalladated fragment conjugated to functionalized bioactive ligands, represents the potential of organometallic systems in generating new bifunctional biomaterials.
authors.affiliation: Centro di Eccellenza CEMIF.CAL-LASCAMM, CR-INSTM Unità della Calabria, Dipartimento di Chimica, Università della Calabria, Italy. d.pucci@unical.it
authors.forename: Daniela
authors.initials: D
authors.lastname: Pucci
authors.forename: Rossana
authors.initials: R
authors.lastname: Bloise
authors.forename: Anna
authors.initials: A
authors.lastname: Bellusci
authors.forename: Sergio
authors.initials: S
authors.lastname: Bernardini
authors.forename: Mauro
authors.initials: M
authors.lastname: Ghedini
authors.forename: Sante
authors.initials: S
authors.lastname: Pirillo
authors.forename: Alessandra
authors.initials: A
authors.lastname: Valentini
authors.forename: Alessandra
authors.initials: A
authors.lastname: Crispini
mesh_terms: D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D018360:Crystallography, X-Ray; D003474:Curcumin / Q000737:chemistry*; D006801:Humans; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D009942:Organometallic Compounds; D003474:Curcumin