title: Chronic 3,4-methylenedioxymethamphetamine treatment suppresses cell proliferation in the adult mouse dentate gyrus.
abstract: We investigated the influence of chronic 3,4-methylenedioxymethamphetamine (MDMA) treatment on cell proliferation in the adult dentate gyrus. Mice were orally treated with MDMA (1.25 mg/kg-40 mg/kg) or saline for 30 days. To label dividing cells, mice were given 5-bromo-2'-deoxyuridine (BrdU) for 4 days from the day after the last administration of MDMA, and their brains were examined 24 h later. MDMA dose-dependently induced a decrease in the number of BrdU-positive cells in the male and female dentate gyrus. Our results suggest that chronic exposure to MDMA suppresses cell proliferation in the dentate gyrus.
authors.affiliation: Department of Pharmacology, College of Medicine, The Catholic University of Korea, 137-701, Seoul, South Korea.
authors.forename: Kyung-Ok
authors.initials: KO
authors.lastname: Cho
authors.forename: Seul-Ki
authors.initials: SK
authors.lastname: Kim
authors.forename: Gyu Seek
authors.initials: GS
authors.lastname: Rhee
authors.forename: Seung Jun
authors.initials: SJ
authors.lastname: Kwack
authors.forename: Dae Hyun
authors.initials: DH
authors.lastname: Cho
authors.forename: Ki-Wug
authors.initials: KW
authors.lastname: Sung
authors.forename: Seong Yun
authors.initials: SY
authors.lastname: Kim
mesh_terms: D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D018891:Dentate Gyrus / Q000166:cytology / Q000187:drug effects*; D005260:Female; D006213:Hallucinogens / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018817:N-Methyl-3,4-methylenedioxyamphetamine / Q000494:pharmacology*; D018490:Serotonin Agents / Q000494:pharmacology
chemical_list: D006213:Hallucinogens; D018490:Serotonin Agents; D018817:N-Methyl-3,4-methylenedioxyamphetamine