Mechanosensitive channels in bacteria: signs of closure?
Bacterial mechanosensitive channels are activated by increases in tension in the lipid bilayer of the cytoplasmic membrane, where they transiently create large pores in a controlled manner. Mechanosensitive channel research has benefited from advances in electrophysiology, genomics and molecular genetics as well as from the application of biophysical techniques. Most recently, new analytical methods have been used to complement existing knowledge and generate insights into the molecular interactions that take place between mechanosensitive channel proteins and the surrounding membrane lipids. This article reviews the latest developments.
Booth
Ian R
IR
School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Aberdeen, AB25 2ZD, UK. i.r.booth@abdn.ac.uk
Edwards
Michelle D
MD
Black
Susan
S
Schumann
Ulrike
U
Miller
Samantha
S
D018407:Bacterial Physiological Phenomena; D002462:Cell Membrane / Q000502:physiology*; D006874:Hydrostatic Pressure; D007473:Ion Channels / Q000502:physiology*; D008563:Membrane Lipids / Q000378:metabolism; D008565:Membrane Proteins / Q000378:metabolism
D007473:Ion Channels; D008563:Membrane Lipids; D008565:Membrane Proteins