[Interceptors:--"silent" chemokine receptors].
The physiological effect caused by chemokines is regulated by interactions with a group of rodopsin-like G protein-coupled receptors (GPCRs). These receptors share a number of common features: the polypeptide chain is a 7-transmembrane ?-helix (7 TMD motif) and the region involved in G-protein interaction (the DRYLAIV sequence) is located in the second transmembrane loop. So far, 19 chemokine receptors have been identified. Three of them (Duffy glycoprotein, D6, and CCX-CKR proteins), although structurally related to other GPCRs, lack the ability of G-protein signal transduction. Instead, they efficiently internalize their cognate ligands, regulating chemokine levels in various body compartments. These three proteins are suggested to form a distinct chemokine receptor family, designated "interceptors" or "silent" chemokine receptors.
Grodecka
Magdalena
M
Instytut Immunologii i Terapii Doświadczalnej PAN im. L. Hirszfelda we Wrocławiu, Poland.
Waśniowska
Kazimiera
K
D020816:Amino Acid Motifs; D000818:Animals; D002478:Cells, Cultured; D018925:Chemokines / Q000378:metabolism*; D016384:Consensus Sequence; D004375:Duffy Blood-Group System / Q000502:physiology*; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D051379:Mice; D021381:Protein Transport; D054388:Receptors, CCR; D054447:Receptors, CCR10; D019707:Receptors, Chemokine / Q000502:physiology*; D051116:Receptors, Scavenger / Q000502:physiology*; D015398:Signal Transduction; D009626:Terminology as Topic; D000097628:Chemokine Receptor D6
D018925:Chemokines; D004375:Duffy Blood-Group System; D054388:Receptors, CCR; D054447:Receptors, CCR10; D019707:Receptors, Chemokine; D051116:Receptors, Scavenger; D000097628:Chemokine Receptor D6; C408223:ACKR4 protein, human