title: Hepatic encephalopathy due to TIPS--retrospective study.
abstract: OBJECTIVE
  The main problem of transjugular intrahepatic portosystemic shunt is high incidence of hepatic encephalopathy (HE). The aim of our retrospective study was to determine the incidence the risk factors of clinically significant encephalopathy.
  
  
  METHODS
  430 patients with liver cirrhosis treated by TIPS in Faculty Hospital in Hradec Králové, Czech Republic.
  
  
  RESULTS
  Incidence of HE was 35.8%. Patients with HE were older (57.7 +/- 12.1 years) than patients without HE (50 +/- 1.4 years) (p < 0.001). HE developed in 28.6% in patients with ethylic etiology and in 43.9% in patients with non-ethylic etiology (p < 0.001). In diabetic patients HE developed in 51.6% (47 of 111), as compared with 30.5% (44 of 319) in non-diabetic patients (p < 0.01). We did not observe a difference in the incidence of HE in relation to sex, stage of cirrhosis, diameter of the stent nor the drop of the portosystemic gradient. Multivariance analysis revealed however to be statistically significantly conditioned by age and not by the presence of diabetes or etiology of liver cirrhosis.
  
  
  CONCLUSIONS
  The risk factors for HE in our patients were older age, other than ethylic etiology of liver cirrhosis and diabetes mellitus. There was no direct relationship between the development of HE and other investigated parameters.
authors.affiliation: Department of Internal Medicine, Faculty Hospital in Hradec Kralove, Czech Republic. dufinjoz@fnhk.cz
authors.forename: Jozefína
authors.initials: J
authors.lastname: Stefánková
authors.forename: Petr
authors.initials: P
authors.lastname: Hůleki
authors.forename: Anush
authors.initials: A
authors.lastname: Babu
authors.forename: Eva
authors.initials: E
authors.lastname: Cermáková
authors.forename: Václav
authors.initials: V
authors.lastname: Safka
authors.forename: Josef
authors.initials: J
authors.lastname: Stefanek
authors.forename: Tomás
authors.initials: T
authors.lastname: Fejfar
authors.forename: Antonin
authors.initials: A
authors.lastname: Krajina
mesh_terms: D000328:Adult; D000368:Aged; D003430:Cross-Sectional Studies; D018153:Czech Republic; D003920:Diabetes Mellitus / Q000453:epidemiology; D005260:Female; D006501:Hepatic Encephalopathy / Q000453:epidemiology / Q000209:etiology*; D006801:Humans; D015994:Incidence; D008104:Liver Cirrhosis, Alcoholic / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D019168:Portasystemic Shunt, Transjugular Intrahepatic / Q000009:adverse effects*; D011183:Postoperative Complications / Q000209:etiology*; D012189:Retrospective Studies; D012307:Risk Factors