title: 4-Phenyl-4-[1H-imidazol-2-yl]-piperidine derivatives as non-peptidic selective delta-opioid agonists with potential anxiolytic/antidepressant properties. Part 2.
abstract: Novel 4-phenyl-4-[1H-imidazol-2-yl]-piperidine derivatives have been prepared and their synthesis described herein. In vitro affinities for delta-, micro-, and kappa-opioid receptors are reported. Evaluation of some representative compounds from this series in the mouse neonatal ultrasonic vocalization test and the mouse tail suspension test revealed anxiolytic- and antidepressant-like effects, respectively, upon subcutaneous administration.
authors.affiliation: Johnson & Johnson Pharmaceutical Research & Development, Research & Early Development Europe, CNS-Psychiatry, Spain. atrabanc@prdes.jnj.com
authors.forename: Andrés A
authors.initials: AA
authors.lastname: Trabanco
authors.forename: Nancy
authors.initials: N
authors.lastname: Aerts
authors.forename: Rosa M
authors.initials: RM
authors.lastname: Alvarez
authors.forename: José I
authors.initials: JI
authors.lastname: Andrés
authors.forename: Inge
authors.initials: I
authors.lastname: Boeckx
authors.forename: Javier
authors.initials: J
authors.lastname: Fernández
authors.forename: Antonio
authors.initials: A
authors.lastname: Gómez
authors.forename: Frans E
authors.initials: FE
authors.lastname: Janssens
authors.forename: Joseph E
authors.initials: JE
authors.lastname: Leenaerts
authors.forename: Ana I
authors.initials: AI
authors.lastname: De Lucas
authors.forename: Encarna
authors.initials: E
authors.lastname: Matesanz
authors.forename: Thomas
authors.initials: T
authors.lastname: Steckler
authors.forename: Shirley
authors.initials: S
authors.lastname: Pullan
mesh_terms: D014151:Anti-Anxiety Agents / Q000737:chemistry / Q000494:pharmacology*; D000928:Antidepressive Agents / Q000737:chemistry / Q000494:pharmacology*; D010880:Piperidines / Q000737:chemistry / Q000494:pharmacology*; D017465:Receptors, Opioid, delta / Q000819:agonists*
chemical_list: C508741:4-phenyl-4-(1H-imidazol-2-yl)piperidine; D014151:Anti-Anxiety Agents; D000928:Antidepressive Agents; D010880:Piperidines; D017465:Receptors, Opioid, delta