title: Mandible metastasis as the first sign from primary adenocarcinoma of the lung.
abstract: Adenocarcinoma of the lung that metastasizes to the mandible is very uncommon; only a few cases have been described in the English-language literature. This article presents a metastasis from adenocarcinoma of the lung affecting the mandible of a 64-year-old woman, in which the first discovered metastatic lesion was detected before the primary tumor. The immunoreactivity for human thyroid transcription factor-1 (TTF-1) in the oral lesion was essential for determining the site and type of the primary tumor, as the patient showed no clinical or radiographic evidence of a tumor in the thyroid gland. After the primary tumor in the lung was diagnosed, radiotherapy and chemotherapy were initiated; unfortunately, the patient died two months after the start of treatment. This article emphasizes the importance of a well-conducted examination for diagnosing metastatic oral lesions.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Araraquara Dental School, UNESP, Sao Paulo, Brazil.
authors.forename: Valfrido Antonio
authors.initials: VA
authors.lastname: Pereira-Filho
authors.forename: Marcelo Donizetti
authors.initials: MD
authors.lastname: Chaves
authors.forename: Jorge
authors.initials: J
authors.lastname: Haddad
authors.forename: Mario Francisco Real
authors.initials: MF
authors.lastname: Gabrielli
authors.forename: Marisa Aparecida Cabrini
authors.initials: MA
authors.lastname: Gabrielli
authors.forename: Eduardo
authors.initials: E
authors.lastname: Hochulli-Vieira
authors.forename: Pablo Agustin
authors.initials: PA
authors.lastname: Vargas
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology / Q000556:secondary*; D017809:Fatal Outcome; D005260:Female; D018398:Homeodomain Proteins / Q000032:analysis; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000473:pathology; D008339:Mandibular Neoplasms / Q000556:secondary*; D008875:Middle Aged; D009687:Nuclear Proteins / Q000032:analysis; D012888:Skull Neoplasms / Q000556:secondary; D000074482:Thyroid Nuclear Factor 1; D014157:Transcription Factors / Q000032:analysis
chemical_list: D018398:Homeodomain Proteins; C000614412:NKX2-1 protein, human; D009687:Nuclear Proteins; D000074482:Thyroid Nuclear Factor 1; D014157:Transcription Factors