title: Bone response to three different chemical compositions of fluorcanasite glass-ceramic.
abstract: The aim of this study was to evaluate the bone response to three fluorcanasite glass-ceramic compositions with different solubilities (K3, K5, and K8) after implantation in a femur rabbit model. Fluorcanasite glass-ceramic rods were implanted bilaterally in the mid-shafts rabbit femurs. Implants were harvested at 8 and 12 weeks and prepared for histological and histomorphometric analyses at the light microscope level. Bioglass 45S5 rods were used as a control material. At 8 weeks, all fluorcanasite glass-ceramics were entirely surrounded by a nonmineralized connective tissue. At 12 weeks, reduced areas of bone tissue were observed in the cortical area in direct contact with the K3 and K5 fluorcanasite glass-ceramics compared to Bioglass 45S5, whereas no bone tissue was observed in direct contact with the K8 surface. Bone-to-implant contact in the cortical area was affected by the material chemical composition and ranked as follows: Bioglass 45S5>K3>K5>K8 (p=0.001). In the bone marrow, a layer of fibrous connective tissue formed in direct contact with the fluorcanasite glass-ceramics and Bioglass 45S5, and only rarely exhibited contact osteogenesis. All the fluorcanasite glass-ceramics appeared to degrade in the biological environment. The solubility ratio did not alter significantly the biological reply of the fluorcanasite glass-ceramics in vivo. Further modifications of the chemical composition of the fluorcanasite glass-ceramic are required to increase the stability of the material in vivo.
authors.affiliation: Department of Oral and Maxillofacial Surgery and Periodontology, School of Dentistry of Ribeirao Preto, University of Sao Paulo, SP, Brazil. vmbarros@forp.usp.br
authors.forename: Valdemar Mallet
authors.initials: VM
authors.lastname: da Rocha Barros
authors.forename: Jorge Luiz J
authors.initials: JL
authors.lastname: Liporaci
authors.forename: Adalberto L
authors.initials: AL
authors.lastname: Rosa
authors.forename: Marcela Caffarena
authors.initials: MC
authors.lastname: Junqueira
authors.forename: Paulo Tambasco
authors.initials: PT
authors.lastname: de Oliveira
authors.forename: Anthony
authors.initials: A
authors.lastname: Johnson
authors.forename: Richard
authors.initials: R
authors.lastname: van Noort
mesh_terms: D000818:Animals; D002516:Ceramics / Q000737:chemistry* / Q000494:pharmacology*; D005269:Femur / Q000166:cytology / Q000187:drug effects*; D005898:Glass; D008297:Male; D008422:Materials Testing; D019919:Prosthesis Implantation; D011817:Rabbits; D017640:Silicates / Q000737:chemistry* / Q000494:pharmacology*; D012995:Solubility / Q000187:drug effects
chemical_list: D017640:Silicates; C425330:bioactive glass 45S5; C481899:fluorcanasite; C023506:Glass ceramics