title: [Anti-HIV chemical constituents of aerial parts of Caragana rosea].
abstract: This study was intended to look for anti-HIV chemical constituents of aerial parts of Caragana rosea Turcz. Column chromatographic technique was used for the isolation and purification of constituents of Caragana rosea under the guide of anti-HIV assay. The structures were established on the basis of physical and chemical properties and spectroscopic data. Five compounds were obtained from the EtOAc fraction of aerial parts of Caragana rosea and identified as myricetin (1), mearnsetin (2), p-hydroxy cinnamic acid (3), cararosinol A (4) and cararosinol B (5). At the same time, one possible transformation route between cararosinol B and kobophenol A, another resveratrol tetramer isolated from this plant previously, was proposed. Compounds 4, 5 are new resveratrol tetramers, compounds 1 -3 were isolated from this plant for the first time. All compounds showed no activities in an in vitro assay against HIV-1.
authors.affiliation: School of Pharmacy, Fudan University, Shanghai 200032, China. gxyang@shmu.edu.cn
authors.forename: Guo-xun
authors.initials: GX
authors.lastname: Yang
authors.forename: Jian-bin
authors.initials: JB
authors.lastname: Qi
authors.forename: Ke-jun
authors.initials: KJ
authors.lastname: Cheng
authors.forename: Chang-qi
authors.initials: CQ
authors.lastname: Hu
mesh_terms: D019380:Anti-HIV Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D001572:Benzofurans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D032602:Caragana / Q000737:chemistry*; D003373:Coumaric Acids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D015497:HIV-1 / Q000187:drug effects; D015394:Molecular Structure; D035261:Plant Components, Aerial / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry*; D011422:Propionates; D013267:Stilbenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D019380:Anti-HIV Agents; D001572:Benzofurans; D003373:Coumaric Acids; D005419:Flavonoids; D011422:Propionates; D013267:Stilbenes; C510380:kobophenol A; C040015:myricetin; C495469:p-coumaric acid