title: A brain-derived neurotrophic factor (BDNF) haplotype is associated with antidepressant treatment outcome in mood disorders.
abstract: Brain-derived neurotrophic factor (BDNF) has been studied extensively in relation to the susceptibility to mood disorders (MD), although it remains to be clarified whether BDNF is a susceptibility locus for MD phenotypes, including therapeutic response to antidepressants. We have performed a single-marker and haplotype association study of eight TagSNPs polymorphisms in the genomic region containing the BDNF gene in 342 control subjects and 374 patients with MD, and have tested the association with antidepressant treatment outcome. None of the eight single nucleotide polymorphisms (TagSNPs) was significantly associated with MD phenotype after Bonferroni correction. In the single-marker analysis, a SNP was found to be associated with the patient's state of 'remitter' after adequate trial with a single antidepressant phenotype (odds ratio (OR)=2.95; P=0.0025). We also identified a haplotype associated with this phenotype. This study supports the implication of BDNF in antidepressant treatment outcome in MD, with specific association with 5' upstream region of BDNF gene.
authors.affiliation: Genes and Disease Program, and CeGen Barcelona Genotyping Node, Center for Genomic Regulation (CRG), Barcelona, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Gratacòs
authors.forename: V
authors.initials: V
authors.lastname: Soria
authors.forename: M
authors.initials: M
authors.lastname: Urretavizcaya
authors.forename: J R
authors.initials: JR
authors.lastname: González
authors.forename: J M
authors.initials: JM
authors.lastname: Crespo
authors.forename: M
authors.initials: M
authors.lastname: Bayés
authors.forename: R
authors.initials: R
authors.lastname: de Cid
authors.forename: J M
authors.initials: JM
authors.lastname: Menchón
authors.forename: J
authors.initials: J
authors.lastname: Vallejo
authors.forename: X
authors.initials: X
authors.lastname: Estivill
mesh_terms: D020121:5' Untranslated Regions; D000328:Adult; D000368:Aged; D000928:Antidepressive Agents / Q000627:therapeutic use*; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D016022:Case-Control Studies; D003865:Major Depressive Disorder / Q000188:drug therapy / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D019964:Mood Disorders / Q000188:drug therapy* / Q000235:genetics; D016017:Odds Ratio; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D013030:Spain; D016896:Treatment Outcome
chemical_list: D020121:5' Untranslated Regions; D000928:Antidepressive Agents; D019208:Brain-Derived Neurotrophic Factor