Activities of Z-ajoene against tumour and viral spreading in vitro.
Z-ajoene is a garlic-derived compound with known anti-tumour properties. This report argues in favour of pro-apoptotic and cell cycle blockage activities of Z-ajoene on various cell lines involving activation of the p53-family gene products, p53, p63 and p73, at indicated doses. According to its known anti-proteasome activity, Z-ajoene induced a downregulation of MHC-class I expression at the surface of treated cells but did not impair their recognition by CD8+ T cells. We further demonstrated a new activity of Z-ajoene against human cytomegalovirus spreading in vitro that was mediated by an increased number of apoptotic cells after infection. Altogether our data point at the ubiquitous efficiency of Z-ajoene as a new compound to fight against cancers of various origins including those that put up viruses.
Terrasson
Jerome
J
INSERM U563, CHU Purpan, BP 3028, Toulouse Cédex 3, F-31024, France.
Xu
Bo
B
Li
Min
M
Allart
Sophie
S
Davignon
Jean-Luc
JL
Zhang
Li-he
LH
Wang
Kui
K
Davrinche
Christian
C
D000970:Antineoplastic Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D018414:CD8-Positive T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D045744:Cell Line, Tumor; D003587:Cytomegalovirus / Q000187:drug effects* / Q000502:physiology; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D004220:Disulfides / Q000494:pharmacology*; D005347:Fibroblasts / Q000187:drug effects / Q000821:virology; D005805:Genes, MHC Class I / Q000502:physiology; D015789:HLA-A2 Antigen / Q000378:metabolism; D006801:Humans; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D013454:Sulfoxides; D015534:Trans-Activators / Q000235:genetics / Q000378:metabolism; D014157:Transcription Factors; D000072160:Tumor Protein p73; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism; D025521:Tumor Suppressor Proteins / Q000235:genetics / Q000378:metabolism
D000970:Antineoplastic Agents; D004268:DNA-Binding Proteins; D004220:Disulfides; D015789:HLA-A2 Antigen; D009687:Nuclear Proteins; D012333:RNA, Messenger; D013454:Sulfoxides; C115051:TP63 protein, human; C000606460:TP73 protein, human; D015534:Trans-Activators; D014157:Transcription Factors; D000072160:Tumor Protein p73; D016159:Tumor Suppressor Protein p53; D025521:Tumor Suppressor Proteins; C048980:ajoene; D046988:Proteasome Endopeptidase Complex