Vaccine-associated paralytic poliomyelitis in a patient with MHC class II deficiency.
Vaccine-associated paralytic poliomyelitis (VAPP) is a rare complication of oral polio vaccine. We describe a fatal case of VAPP in an 8-month-old boy with Major Histocompatibility Class II deficiency. The isolated poliovirus was a Sabin type 2-type 1 recombinant that showed 1.4% VP1 divergence from Sabin type 2.
Parvaneh
Nima
N
Department of Pediatrics, Infectious Disease Research Center, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
Shahmahmoudi
Shohreh
S
Tabatabai
Hamideh
H
Zahraei
Mohsen
M
Mousavi
Taha
T
Esteghamati
Abdol-Reza
AR
Gooya
Mohammad M
MM
Mamishi
Setareh
S
Nategh
Rakhshandeh
R
Kew
Olen M
OM
D004797:Enzyme-Linked Immunosorbent Assay; D017809:Fatal Outcome; D000949:Histocompatibility Antigens Class II; D006801:Humans; D016867:Immunocompromised Host; D007153:Immunologic Deficiency Syndromes / Q000150:complications*; D007223:Infant; D008297:Male; D011051:Poliomyelitis / Q000209:etiology* / Q000517:prevention & control; D011055:Poliovirus Vaccine, Oral / Q000009:adverse effects* / Q000276:immunology; D016133:Polymerase Chain Reaction
D000949:Histocompatibility Antigens Class II; D011055:Poliovirus Vaccine, Oral