title: Why is Wallerian degeneration in the CNS so slow?
abstract: Wallerian degeneration (WD) is the set of molecular and cellular events by which degenerating axons and myelin are cleared after injury. Why WD is rapid and robust in the PNS but slow and incomplete in the CNS is a longstanding mystery. Here we review current work on the mechanisms of WD with an emphasis on deciphering this mystery and on understanding whether slow WD in the CNS could account for the failure of CNS axons to regenerate.
authors.affiliation: Department of Neurobiology, Stanford University School of Medicine, Stanford, California 94305, USA. mevargas@stanford.edu
authors.forename: Mauricio E
authors.initials: ME
authors.lastname: Vargas
authors.forename: Ben A
authors.initials: BA
authors.lastname: Barres
mesh_terms: D000818:Animals; D000906:Antibodies / Q000276:immunology; D001369:Axons / Q000378:metabolism / Q000473:pathology*; D002493:Central Nervous System Diseases / Q000378:metabolism / Q000503:physiopathology*; D006801:Humans; D008264:Macrophages / Q000502:physiology; D009186:Myelin Sheath / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D009416:Nerve Regeneration / Q000502:physiology; D009457:Neuroglia / Q000502:physiology; D010587:Phagocytosis / Q000502:physiology; D013997:Time Factors; D014855:Wallerian Degeneration / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology*
chemical_list: D000906:Antibodies