Nagelamide J, a novel dimeric bromopyrrole alkaloid from a sponge Agelas species.
A novel dimeric bromopyrrole alkaloid, nagelamide J (1), with antimicrobial activity has been isolated from an Okinawan marine sponge Agelas species, and the structure and stereochemistry were elucidated from spectroscopic data. Nagelamide J (1) is the first bromopyrrole alkaloid possessing a cyclopentane ring fused to an amino imidazole ring.
Araki
Atsushi
A
Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.
Tsuda
Masashi
M
Kubota
Takaaki
T
Mikami
Yuzuru
Y
Fromont
Jane
J
Kobayashi
Jun'ichi
J
D047230:Agelas / Q000737:chemistry*; D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D000818:Animals; D003455:Cryptococcus neoformans / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D015394:Molecular Structure; D011758:Pyrroles / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D012680:Sensitivity and Specificity; D013045:Species Specificity; D013211:Staphylococcus aureus / Q000187:drug effects; D013329:Structure-Activity Relationship
D000470:Alkaloids; D011758:Pyrroles; C521922:nagelamide J