Preparation and stability of cosmetic formulations with an anti-aging peptide.
Wrinkling of the skin is the most obvious sign of deterioration of the human body with age. This process involves a number of genetic, constitutional, hormonal, nutritional, and environmental factors, in addition to the influence of frequently repeated facial movements during laughing, smoking, etc. This article reviews the physiological basis and mechanism of action of the active cosmetic ingredient acetyl hexapeptide-8 (Argireline). We prepared two formulations: an emulsion with an external aqueous phase for normal to dry skin, and a gel for oily skin. Laboratory analyses, rheology tests and in vitro release assays were used to evaluate the stability of these formulations for cosmetic treatment.
Ruiz
M A
MA
Departamento de Farmacia y Tecnología Farmacéutica, Universidad de Granada, 10871 Granada, Spain.
Clares
B
B
Morales
M E
ME
Cazalla
S
S
Gallardo
V
V
D002626:Chemistry, Pharmaceutical; D003358:Cosmetics / Q000737:chemistry* / Q000627:therapeutic use; D004355:Drug Stability; D004655:Emulsions / Q000737:chemistry / Q000627:therapeutic use; D005148:Facial Dermatoses / Q000188:drug therapy; D006801:Humans; D009842:Oligopeptides / Q000737:chemistry* / Q000627:therapeutic use; D010455:Peptides / Q000737:chemistry* / Q000627:therapeutic use
D003358:Cosmetics; D004655:Emulsions; D009842:Oligopeptides; D010455:Peptides; C582852:acetyl-glutamyl-glutamyl-methionyl-glutaminyl-arginyl-argininamide