A highly alpha-regioselective AgOTf-catalyzed nucleophilic substitution of the Baylis-Hillman acetates with indoles.
An efficient method for highly alpha-regioselective nucleophilic substitution of the Baylis-Hillman acetates with indoles catalyzed by AgOTf in high yields (72-99%) has been developed. Reductive cyclization of the substitution products furnished the azepinoindole derivatives in good yields (up to 93%).
Shafiq
Zahid
Z
Beijing National Laboratory for Molecular Sciences (BNLMS), Laboratory for Chemical Biology, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China.
Liu
Li
L
Liu
Zhe
Z
Wang
Dong
D
Chen
Yong-Jun
YJ