Regulation of the mast cell response to the type 1 Fc epsilon receptor.
The type I Fc epsilon receptor (Fc epsilon RI) is one of the better understood members of its class and is central to the immunological activation of mast cells and basophils, the key players in immunoglobulin E (IgE)-dependent immediate hypersensitivity. This review provides background information on several distinct regulatory mechanisms controlling this receptor's stimulus-response coupling network. First, we review the current understanding of this network's operation, and then we focus on the inhibitory regulatory mechanisms. In particular, we discuss the different known cytosolic molecules (e.g. kinases, phosphatases, and adapters) as well as cell membrane proteins involved in negatively regulating the Fc epsilon RI-induced secretory responses. Knowledge of this field is developing at a fast rate, as new proteins endowed with regulatory functions are still being discovered. Our understanding of the complex networks by which these proteins exert regulation is limited. Although the scope of this review does not include addressing several important biochemical and biophysical aspects of the regulatory mechanisms, it does provide general insights into a central field in immunology.
Abramson
Jakub
J
Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel.
Pecht
Israel
I
D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism; D000595:Amino Acid Sequence; D000818:Animals; D003600:Cytosol / Q000201:enzymology / Q000378:metabolism*; D006801:Humans; D008407:Mast Cells / Q000201:enzymology / Q000276:immunology*; D008969:Molecular Sequence Data; D010744:Phosphoric Monoester Hydrolases / Q000276:immunology; D011494:Protein Kinases / Q000378:metabolism; D017455:Receptors, IgE / Q000819:agonists / Q000276:immunology*; D011971:Receptors, Immunologic / Q000276:immunology; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism
D048868:Adaptor Proteins, Signal Transducing; D017455:Receptors, IgE; D011971:Receptors, Immunologic; D044767:Ubiquitin-Protein Ligases; D011494:Protein Kinases; D010744:Phosphoric Monoester Hydrolases