title: Capit timed tests quantify age-related motor decline in normal subjects.
abstract: Slowing of motor performance in human aging is a well demonstrated clinical observation. Age-related motor decline has been also confirmed in animal models including rodents and non human primates. We studied the motor performance of 60 normal subjects (age: 20-87). Motor study included the four timed tests (TT) recommended in CAPIT protocol: pronation-supination (PS), finger dexterity (FD), movement between two points (MTP) or tapping, and walking test (WT). Finally we compared normal controls with a group of 30 patients with Parkinson's disease (PD) of similar age. Age inversely correlated with TT performance in normal subjects (for PS, r:0.33, p<0.01; FD, r:0.44, p<0.0005; MTP, r:0.51, p<0.0001; WT, r:0.59, p<0.0001, Pearson). Our results confirm that motor performance (measured with CAPIT TT) deteriorates linearly with age. Simple tasks, such as CAPIT TT can help to study and quantify age-related motor decline.
authors.affiliation: Department of Neurology, Fundación Jiménez Díaz, Madrid, Spain. pgarcia@fjd.es
authors.forename: Pedro J Garcia
authors.initials: PJ
authors.lastname: Ruiz
authors.forename: Vicenta Sanchez
authors.initials: VS
authors.lastname: Bernardos
authors.forename: Manuel
authors.initials: M
authors.lastname: Bartolomé
authors.forename: Araceli García
authors.initials: AG
authors.lastname: Torres
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D004185:Disability Evaluation; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009048:Motor Skills / Q000502:physiology*; D009068:Movement / Q000502:physiology*; D009069:Movement Disorders / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology*; D009460:Neurologic Examination; D010300:Parkinson Disease / Q000503:physiopathology; D012016:Reference Values