Cyathusals A, B, and C, antioxidants from the fermented mushroom Cyathus stercoreus.
Three new polyketide-type antioxidative compounds, cyathusals A (1), B (2), and C (3), and the known pulvinatal (4) were obtained from the fermented mushroom Cyathus stercoreus. The structures of the compounds were characterized on the basis of NMR and mass spectroscopic data. Cyathusals A, B, and C and pulvinatal showed free radical scavenging activities on the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical with EC50 values of 41.6, 46.0, 26.6, and 28.6 microM, respectively, and on the 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonate) (ABTS) cation radical with EC50 values of 7.9, 11.1, 9.1, and 8.4 microM, respectively.
Kang
Hahk-Soo
HS
KRIBB, 52 Eoeun-dong, Yuseong, Daejeon 305-806, Korea.
Jun
Eun-Mi
EM
Park
Soon-Hye
SH
Heo
Soo-Jin
SJ
Lee
Tae-Soo
TS
Yoo
Ick-Dong
ID
Kim
Jong-Pyung
JP
D000363:Agaricales / Q000737:chemistry*; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001713:Biphenyl Compounds; D005285:Fermentation; D016166:Free Radical Scavengers / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006575:Heterocyclic Compounds, 3-Ring / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D007723:Korea; D019906:Nuclear Magnetic Resonance, Biomolecular; D010851:Picrates / Q000494:pharmacology
D000975:Antioxidants; D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D006575:Heterocyclic Compounds, 3-Ring; D010851:Picrates; C521648:cyathusal B; C004931:1,1-diphenyl-2-picrylhydrazyl; C521647:cyathusal C; C521646:cyathusal A