Mycoplasmal membrane protein p37 promotes malignant changes in mammalian cells.
Evidence of Mycoplasma hyorhinis infection in human gastric cancer tissues has been found in previous work. In this study, we demonstrate that the expression of p37, a membrane lipoprotein of M. hyorhinis, in mammalian cells induces antisenescence, enhances clonogenicity in soft agar, and co-operates with human epidermal growth factor receptor-related 2 to inhibit cell adhesion. Conversely, truncated p37 protein, with the first 28 amino acids deleted from its N terminal, promotes cell senescence. Taken together, our findings suggest that p37 promotes malignant changes in mammalian cells. With the identification of this molecular component, which is responsible for mycoplasma malignancy-promoting activity, it is possible that a better understanding of the relationship between M. hyorhinis infection and human gastric cancers will lead to novel diagnostics and therapeutics.
Liu
Wenbin
W
Department of Biochemistry and Molecular Biology, Peking University School of Oncology and Beijing Cancer Hospital and Institute, 52 Fu-Cheng Road, Haidian District, Beijing, 100036 People's Republic of China.
Ren
Tingting
T
Jiang
Beihai
B
Gong
Manman
M
Shou
Chengchao
C
D001426:Bacterial Proteins / Q000502:physiology*; D002448:Cell Adhesion; D045744:Cell Line, Tumor; D002471:Cell Transformation, Neoplastic; D016922:Cellular Senescence; D006801:Humans; D008565:Membrane Proteins / Q000502:physiology*; D009175:Mycoplasma Infections / Q000150:complications; D045790:Mycoplasma hyorhinis / Q000472:pathogenicity*; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000502:physiology; D013274:Stomach Neoplasms / Q000209:etiology
D001426:Bacterial Proteins; D008565:Membrane Proteins; D018719:Erb-b2 Receptor Tyrosine Kinases