Chemotherapy of leishmaniasis. Part VII: synthesis and bioevaluation of substituted terpenyl pyrimidines.
Some novel 4-N-substituted terpenyl pyrimidines 5(a-d) and 7(a-g) have been synthesized using novel synthetic methods. The compounds were screened for in vivo antileishmanial screening. When compared to 4-thiomethoxy substituted pyrimidine 2 4-N-substituted terpenyl pyrimidines 5(a-d) and 7(a-g) were found inactive.
Suryawanshi
S N
SN
Division of Medicinal Chemistry, Central Drug Research Institute, Chatter Manzil, Lucknow 226001, Uttar Pradesh, India. shivajins@yahoo.co.in
Bhat
B A
BA
Pandey
Susmita
S
Chandra
Naveen
N
Gupta
Suman
S
D000818:Animals; D000981:Antiprotozoal Agents / Q000627:therapeutic use*; D006224:Cricetinae; D004353:Drug Evaluation, Preclinical; D007896:Leishmaniasis / Q000188:drug therapy*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D013058:Mass Spectrometry; D008647:Mesocricetus; D011743:Pyrimidines / Q000627:therapeutic use*; D013055:Spectrophotometry, Infrared
D000981:Antiprotozoal Agents; D011743:Pyrimidines