[Effection of compositie salviae dropping pill on hyperlipemia patients with phlegm and blood stasis syndrome].
OBJECTIVE
To explore the effect of compositie salviae dropping pill (CSDP) on hyperlipemia patients with phlegm and blood stasis syndrome.


METHODS
Hyperlipemia patients were divided randomly into two groups. One group of 40 patients were treated by CSDP, another group of 41 patients were treated by simvastatin. The TC, TG, HDL-C, LDL-C, ApoA and ApoB levels, ALT, r-GT, IL-6, MDA level and SOD activity were determined before and after being treated.


RESULTS
After 3 months treatment, the TC, TG and LDL-C levels were obviously decreased in two groups (P <0.01, P < 0.05), there is no significant difference between the effective rate of two groups. The ALT, r-GT, IL-8 and MDA levels of treatment group were obviously decreased (P < 0.01, P < 0.05), while the ApoA level and SOD activity increased obviously in those patients (P <0.05, P <0.01, respectively). However, the ALT, r-GT, IL-6, MDA, HDL-C, ApoA level and SOD activity had no significant difference after treatment in control group.


CONCLUSIONS
Our study suggest that CSDP have the function of falling serum lipid level without damaging liver function, its function of protecting liver function might related to its function of improving of anti-oxidation and decreasing of inflammation, the mechanism of CSDP disparting and removing phlem and blood stasis in the processes lipid metabolism need to be studied further.
Zhang
Shi-Jun
SJ
The First Affiliated Hospital of Sun Yat-Sen Universty, Guangzhou 510080, China. zhsjun1967@hotmail.com
Cheng
Ze-Xiong
ZX
Lin
You-Wu
YW
Qin
Jian
J
Cheng
Yong-Hua
YH
Liu
Su-Ling
SL
D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D001892:Camphanes; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000302:isolation & purification / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000188:drug therapy*; D015228:Hypertriglyceridemia / Q000097:blood / Q000188:drug therapy*; D016209:Interleukin-8 / Q000097:blood; D008297:Male; D008875:Middle Aged; D053723:Panax notoginseng; D008517:Phytotherapy; D010946:Plants, Medicinal / Q000737:chemistry; D027561:Salvia miltiorrhiza / Q000737:chemistry; D013482:Superoxide Dismutase / Q000097:blood; D005723:gamma-Glutamyltransferase / Q000097:blood
D001892:Camphanes; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D016209:Interleukin-8; C000604051:danshen dripping pill; D013482:Superoxide Dismutase; D005723:gamma-Glutamyltransferase; D000410:Alanine Transaminase