title: Comment on "A centrosome-independent role for gamma-TuRC proteins in the spindle assembly checkpoint".
abstract: Müller et al. (Reports, 27 October 2006, p. 654) showed that inhibition of the gamma-tubulin ring complex (gamma-TuRC) activates the spindle assembly checkpoint (SAC), which led them to suggest that gamma-TuRC proteins play molecular roles in SAC activation. Because gamma-TuRC inhibition leads to pleiotropic spindle defects, which are well known to activate kinetochore-derived checkpoint signaling, we believe that this conclusion is premature.
authors.affiliation: Faculty of Life Sciences, University of Manchester, Manchester, UK. stephen.taylor@manchester.ac.uk
authors.forename: Stephen S
authors.initials: SS
authors.lastname: Taylor
authors.forename: Kevin G
authors.initials: KG
authors.lastname: Hardwick
authors.forename: Kenneth E
authors.initials: KE
authors.lastname: Sawin
authors.forename: Sue
authors.initials: S
authors.lastname: Biggins
authors.forename: Simonetta
authors.initials: S
authors.lastname: Piatti
authors.forename: Alexey
authors.initials: A
authors.lastname: Khodjakov
authors.forename: Conly L
authors.initials: CL
authors.lastname: Rieder
authors.forename: Edward D
authors.initials: ED
authors.lastname: Salmon
authors.forename: Andrea
authors.initials: A
authors.lastname: Musacchio
mesh_terms: D000818:Animals; D018385:Centrosome / Q000502:physiology; D018386:Kinetochores / Q000502:physiology*; D008869:Microtubule-Associated Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism*; D008870:Microtubules / Q000378:metabolism* / Q000648:ultrastructure; D008938:Mitosis; D015398:Signal Transduction; D008941:Spindle Apparatus / Q000378:metabolism*; D014404:Tubulin / Q000378:metabolism*
chemical_list: D008869:Microtubule-Associated Proteins; D014404:Tubulin