A new approach using tissue alkaline phosphatase histochemistry to identify Crohn's disease.
In the present study, we investigate intestinal alkaline phosphatase activity in mucosal biopsies in patients with inflammatory bowel disease. Crohn's disease influences the alkaline phosphatase activity in the intestine, increasing its activity. We present a histochemistry-based method for alkaline phosphatase that is useful for the identification of Crohn's disease and the differentiation of ulcerative colitis.
Torres
M I
MI
Department of Experimental Biology, Faculty of Sciences, University of Jaén, Paraje de las Lagunillas s/n 23071, Jaén, Spain. mitorres@ujaen.es
Lorite
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P
López-Casado
M A
MA
Ríos
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A
D000469:Alkaline Phosphatase; D000951:Antigens, Neoplasm / Q000032:analysis*; D003093:Colitis, Ulcerative / Q000175:diagnosis* / Q000201:enzymology / Q000473:pathology; D003424:Crohn Disease / Q000175:diagnosis* / Q000201:enzymology / Q000473:pathology; D003937:Diagnosis, Differential; D058851:GPI-Linked Proteins; D006651:Histocytochemistry / Q000379:methods*; D006801:Humans; D007413:Intestinal Mucosa / Q000201:enzymology* / Q000473:pathology; D011237:Predictive Value of Tests
D000951:Antigens, Neoplasm; D058851:GPI-Linked Proteins; C063088:ALPI protein, human; D000469:Alkaline Phosphatase