Solid state characterization of progesterone in a freeze dried 1:2 progesterone/HPBCD mixture.
Progesterone rapidly dissolves in an aqueous solution containing hydroxypropyl-beta-cyclodextrin (HPBCD) at 1:2 molar ratio, forming a soluble inclusion complex. After filtration and freeze-drying of the final solution, the final powder was examined by SEM, DSC, TGA, XRD, Raman, and FTIR spectroscopy. Experimental results confirm that an inclusion complex exists in the solid state and possible structure of the complex is briefly discussed.
Zoppetti
Giorgio
G
IBSA, Institut Biochimique, Lugano, Switzerland.
Puppini
Nadia
N
Ospitali
Francesca
F
Fini
Adamo
A
D000073738:2-Hydroxypropyl-beta-cyclodextrin; D002152:Calorimetry, Differential Scanning; D002626:Chemistry, Pharmaceutical; D018360:Crystallography, X-Ray; D004355:Drug Stability; D005079:Excipients / Q000737:chemistry*; D005612:Freeze Drying; D008855:Microscopy, Electron, Scanning; D011208:Powders; D011374:Progesterone / Q000737:chemistry*; D011372:Progestins / Q000737:chemistry*; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D013059:Spectrum Analysis, Raman; D013678:Technology, Pharmaceutical / Q000379:methods*; D013818:Thermogravimetry; D014462:Ultrafiltration; D047392:beta-Cyclodextrins / Q000737:chemistry*
D005079:Excipients; D011208:Powders; D011372:Progestins; D047392:beta-Cyclodextrins; D000073738:2-Hydroxypropyl-beta-cyclodextrin; D011374:Progesterone