title: The three families of respiratory NADH dehydrogenases.
abstract: Most reducing equivalents extracted from foodstuffs during oxidative metabolism are fed into the respiratory chains of aerobic bacteria and mitochondria by NADH:quinone oxidoreductases. Three families of enzymes can perform this task and differ remarkably in their complexity and role in energy conversion. Alternative or NDH-2-type NADH dehydrogenases are simple one subunit flavoenzymes that completely dissipate the redox energy of the NADH/quinone couple. Sodium-pumping NADH dehydrogenases (Nqr) that are only found in procaryotes contain several flavins and are integral membrane protein complexes composed of six different subunits. Proton-pumping NADH dehydrogenases (NDH-1 or complex I) are highly complicated membrane protein complexes, composed of up to 45 different subunits, that are found in bacteria and mitochondria. This review gives an overview of the origin, structural and functional properties and physiological significance of these three types of NADH dehydrogenase.
authors.affiliation: Molecular Bioenergetics Group, Centre of Excellence Macromolecular Complexes, Johann Wolfgang Goethe-Universität, 60590, Frankfurt am Main, Germany.
authors.forename: Stefan
authors.initials: S
authors.lastname: Kerscher
authors.forename: Stefan
authors.initials: S
authors.lastname: Dröse
authors.forename: Volker
authors.initials: V
authors.lastname: Zickermann
authors.forename: Ulrich
authors.initials: U
authors.lastname: Brandt
mesh_terms: D000595:Amino Acid Sequence; D001419:Bacteria / Q000378:metabolism; D018407:Bacterial Physiological Phenomena; D002384:Catalysis; D004579:Electron Transport; D042967:Electron Transport Complex I; D008928:Mitochondria / Q000378:metabolism*; D008954:Models, Biological; D008958:Models, Molecular; D008968:Molecular Conformation; D008969:Molecular Sequence Data; D009245:NADH Dehydrogenase / Q000737:chemistry* / Q000502:physiology*; D010802:Phylogeny; D017386:Sequence Homology, Amino Acid; D012964:Sodium / Q000737:chemistry
chemical_list: D012964:Sodium; D009245:NADH Dehydrogenase; D042967:Electron Transport Complex I