[Changes of concentration of renin-angiotensin system components during vibration and their correction in experiment].
The aim of the research was investigation of the state of rennin-angiotensin system during the vibration in rats. 40 (180-200gr) pubertal male rats were studied. One hour vibro seance was conducted every day during two months. The 60 animals were divided into 3 groups (20 rats in each group); the third was control group. On 20th , 40th and 60th days of the experiment the decapitation of the animals was done under general narcosis. the Concentrations of rennin, angiotensin II and angiotensin converted ensyme in the blood plasma was determined using the method of radio immunoassay, The significant changes in concentrations of rennin-angiotensin system components have been manifested. The research showed the destruction in regulation of rennin-angiotensin system. It is concluded, that the vibration provokes the destruction of reciprocal feed-back of rennin-angiotensin system in the rats.
Kapanadze
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D000809:Angiotensins / Q000097:blood; D000818:Animals; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000097:blood; D051381:Rats; D012083:Renin / Q000097:blood; D012084:Renin-Angiotensin System / Q000502:physiology*; D014732:Vibration / Q000009:adverse effects*
D000809:Angiotensins; D007703:Peptidyl-Dipeptidase A; D012083:Renin