"O-acyl isopeptide method" for peptide synthesis: synthesis of forty kinds of "O-acyl isodipeptide unit" Boc-Ser/Thr(Fmoc-Xaa)-OH.
The O-acyl isopeptide method has recently received attention as an efficient synthetic method for peptides. Herein, forty kinds of "O-acyl isodipeptide unit" Boc-Ser/Thr(Fmoc-Xaa)-OH (1-40) were effectively synthesized in two-steps without epimerization. The O-acyl isodipeptide units are important building blocks to enable the routine use of the O-acyl isopeptide method.
Yoshiya
Taku
T
Department of Medicinal Chemistry, Center for frontier Research in Medicinal Science, 21st Century COE program, Kyoto Pharmaceutical University, Yamashina-ku, Kyoto 607-8412, Japan.
Taniguchi
Atsuhiko
A
Sohma
Youhei
Y
Fukao
Fukue
F
Nakamura
Setsuko
S
Abe
Naoko
N
Ito
Nui
N
Skwarczynski
Mariusz
M
Kimura
Tooru
T
Hayashi
Yoshio
Y
Kiso
Yoshiaki
Y
D000595:Amino Acid Sequence; D002625:Chemistry, Organic / Q000379:methods*; D002851:Chromatography, High Pressure Liquid; D004151:Dipeptides / Q000032:analysis / Q000138:chemical synthesis* / Q000737:chemistry; D004951:Esterification; D009980:Influenza A virus / Q000737:chemistry; D007536:Isomerism; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000032:analysis / Q000138:chemical synthesis* / Q000737:chemistry
D004151:Dipeptides; D009842:Oligopeptides