title: Clinical importance of precursor lesions in the pancreas.
abstract: Three distinct noninvasive precursor lesions to invasive ductal adenocarcinoma of the pancreas have been described. These include the mucinous cystic neoplasm, intraductal papillary mucinous neoplasm, and pancreatic intraepithelial neoplasia. The early detection and treatment of these lesions can interrupt the progression of a curable noninvasive precursor to an almost uniformly deadly invasive cancer.
authors.affiliation: Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Weinberg Room 2242, 401 North Broadway, Baltimore, MD, USA.
authors.forename: Ralph H
authors.initials: RH
authors.lastname: Hruban
authors.forename: Kyoichi
authors.initials: K
authors.lastname: Takaori
authors.forename: Marcia
authors.initials: M
authors.lastname: Canto
authors.forename: Elliot K
authors.initials: EK
authors.lastname: Fishman
authors.forename: Kurtis
authors.initials: K
authors.lastname: Campbell
authors.forename: Kieran
authors.initials: K
authors.lastname: Brune
authors.forename: Scott E
authors.initials: SE
authors.lastname: Kern
authors.forename: Michael
authors.initials: M
authors.lastname: Goggins
mesh_terms: D021441:Carcinoma, Pancreatic Ductal / Q000473:pathology; D018450:Disease Progression; D006801:Humans; D010179:Pancreas / Q000473:pathology*; D010190:Pancreatic Neoplasms / Q000473:pathology*; D011230:Precancerous Conditions / Q000473:pathology*