Association between nasal carriage of Staphylococcus aureus and the human complement cascade activator serine protease C1 inhibitor (C1INH) valine vs. methionine polymorphism at amino acid position 480.
Staphylococcus aureus produces compounds that interfere with complement deposition. We hypothesized that humans have developed countermeasures to staphylococcal complement evasion and we screened for single nucleotide polymorphisms in the serine protease C1 inhibitor (C1INH) gene at amino acid position 480 (valine vs. methionine) and nasal carriage of S. aureus. In our study cohort, 38 individuals were persistently colonized by S. aureus, whereas 50 were invariably culture-negative. A trend was observed towards an increased prevalence of the Val/Val genotype in noncarriers compared to persistent carriers (OR 0.50, P=0.07). The Val/Val genotype was significantly overrepresented in noncarriers compared to 463 Caucasian blood donors (OR 0.52, P=0.02). These findings suggest that susceptibility to S. aureus nasal carriage is associated with the C1INH V480M polymorphism.
Emonts
Marieke
M
Department of Pediatrics, Erasmus MC-Sophia, Rotterdam, The Netherlands.
de Jongh
Christa E
CE
Houwing-Duistermaat
Jeanine J
JJ
van Leeuwen
Willem B
WB
de Groot
Ronald
R
Verbrugh
Henri A
HA
Hermans
Peter W M
PW
van Belkum
Alex
A
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000595:Amino Acid Sequence; D019943:Amino Acid Substitution; D002353:Carrier State; D003174:Complement C1 Inactivator Proteins / Q000235:genetics*; D050718:Complement C1 Inhibitor Protein; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008715:Methionine / Q000737:chemistry / Q000235:genetics; D008875:Middle Aged; D008969:Molecular Sequence Data; D009666:Nose / Q000382:microbiology; D011110:Polymorphism, Genetic; D015843:Serpins / Q000235:genetics*; D013203:Staphylococcal Infections / Q000235:genetics*; D013211:Staphylococcus aureus; D014633:Valine / Q000737:chemistry / Q000235:genetics
D003174:Complement C1 Inactivator Proteins; D050718:Complement C1 Inhibitor Protein; C469952:SERPING1 protein, human; D015843:Serpins; D008715:Methionine; D014633:Valine