Cell-cycle control and cortical development.
The spatio-temporal timing of the last round of mitosis, followed by the migration of neuroblasts to the cortical plate leads to the formation of the six-layered cortex that is subdivided into functionally defined cortical areas. Whereas many of the cellular and molecular mechanisms have been established in rodents, there are a number of unique features that require further elucidation in primates. Recent findings both in rodents and in primates indicate that regulation of the cell cycle, specifically of the G1 phase has a crucial role in controlling area-specific rates of neuron production and the generation of cytoarchitectonic maps.
Dehay
Colette
C
INSERM, U846, 18 Avenue Doyen Lépine, 69675 Bron Cedex, France. dehay@lyon.inserm.fr
Kennedy
Henry
H
D000818:Animals; D002450:Cell Communication / Q000235:genetics; D002453:Cell Cycle / Q000235:genetics*; D018797:Cell Cycle Proteins / Q000235:genetics; D002454:Cell Differentiation / Q000502:physiology*; D049109:Cell Proliferation; D002540:Cerebral Cortex / Q000166:cytology / Q000196:embryology* / Q000502:physiology; D016193:G1 Phase / Q000235:genetics; D006801:Humans; D009474:Neurons / Q000166:cytology / Q000502:physiology*; D015398:Signal Transduction / Q000235:genetics; D013234:Stem Cells / Q000166:cytology / Q000502:physiology*
D018797:Cell Cycle Proteins