title: The value of diffusion-weighted imaging in combination with T2-weighted imaging for rectal cancer detection.
abstract: OBJECTIVE
  To evaluate the clinical value of diffusion-weighted imaging (DWI) in combination with T(2)-weighted imaging (T(2)WI) for the detection of rectal cancer as compared with T(2)WI alone.
  
  
  METHODS
  Forty-five patients with rectal cancer and 20 without rectal cancer underwent DWI with parallel imaging and T(2)WI on a 1.5 T scanner. Images were independently reviewed by two readers blinded to the results to determine the detectability of rectal cancer. The detectability of T(2)W imaging without and with DW imaging was assessed by means of receiver operating characteristic analysis. The interobserver agreement between the two readers was calculated with kappa statistics.
  
  
  RESULTS
  The ROC analysis showed that each of two readers achieved more accurate results with T(2)W imaging combined with DW imaging than with T(2)W imaging alone significantly. The A(z) values for the two readers for each T(2)WI and T(2)WI combined with DWI were 0.918 versus 0.991 (p=0.0494), 0.934 versus 0.997 (p=0.0475), respectively. The values of kappa were 0.934 for T(2)WI and 0.948 for T(2)WI combined with DWI between the two readers.
  
  
  CONCLUSIONS
  The addition of DW imaging to conventional T(2)W imaging provides better detection of rectal cancer.
authors.affiliation: Department of Radiology, Zhongshan Hospital, Fudan University, 180 Fenglin Road, 200032 Shanghai, People's Republic of China.
authors.forename: Sheng-Xiang
authors.initials: SX
authors.lastname: Rao
authors.forename: Meng-Su
authors.initials: MS
authors.lastname: Zeng
authors.forename: Cai-Zhong
authors.initials: CZ
authors.lastname: Chen
authors.forename: Ren-Chen
authors.initials: RC
authors.lastname: Li
authors.forename: Shu-Jie
authors.initials: SJ
authors.lastname: Zhang
authors.forename: Jian-Ming
authors.initials: JM
authors.lastname: Xu
authors.forename: Ying-Yong
authors.initials: YY
authors.lastname: Hou
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D012372:ROC Curve; D012004:Rectal Neoplasms / Q000175:diagnosis*