Aging and cancer cell biology, 2007.
This Hot Topics review, the second in a new Aging Cell series, discusses articles published in the last year that have stimulated new ideas about the tangled relationship of aging to cancer cell biology. The year's highlights include reports on the ability of Mdm2 mutations to diminish risks of cancer in aging mice, on proliferative competition between oncogenic cells and bone marrow stem cells, and on the role of metalloproteinases in overcoming age-associated barriers to tumor invasion. Of particular interest were three articles showing that diminished activity of the tumor-suppressor gene p16/INK4a, while increasing the risk of cancer mortality, can lead to improved function in several varieties of age-sensitive stem cells.
Campisi
Judith
J
Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA. jcampisi@lbl.gov
D000368:Aged; D000375:Aging; D000818:Animals; D017209:Apoptosis; D049109:Cell Proliferation; D016922:Cellular Senescence; D019941:Cyclin-Dependent Kinase Inhibitor p16 / Q000378:metabolism; D006801:Humans; D051379:Mice; D008954:Models, Biological; D009154:Mutation; D009369:Neoplasms / Q000473:pathology*; D051736:Proto-Oncogene Proteins c-mdm2 / Q000235:genetics; D013234:Stem Cells / Q000166:cytology; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
D019941:Cyclin-Dependent Kinase Inhibitor p16; D016159:Tumor Suppressor Protein p53; C497206:MDM2 protein, human; D051736:Proto-Oncogene Proteins c-mdm2