Monomeric A beta and metals reduce their cytotoxicities to each other.
The present study has examined the effect of metals, such as iron and copper on the cytotoxicity of amyloid beta protein 1-40 (Abeta40). First, we showed that monomeric Abeta40 has stronger cytotoxicity than various type of aggregated Abeta40. Next we showed the addition of metals into the monomeric Abeta40 reduced the cytotoxicity of either monomeric Abeta40 or metals (iron and copper) although the addition of metals into monomeric Abeta40 resulted in a marked increase of aggregated form of Abeta40, which composed of beta-sheeted Abeta40 and Abeta40 aggregation not characterized by beta-sheet fibrils (coagrated Abeta40). Taken together, the metals and monomeric Abeta40 affect on each other and cause the reduction of their cell toxicity.
Matsuzaki
Shinsuke
S
Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka, Japan. s-matsuzaki@anat2.med.osaka-u.ac.jp
Yasuda
Yuichi
Y
Kobayashi
Shinya
S
Koyama
Yoshihisa
Y
Kawamoto
Keisuke
K
Katayama
Taiichi
T
Tohyama
Masaya
M
D016229:Amyloid beta-Peptides / Q000008:administration & dosage*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D006801:Humans; D008670:Metals / Q000633:toxicity*; D009447:Neuroblastoma / Q000473:pathology*; D010446:Peptide Fragments / Q000008:administration & dosage*
D016229:Amyloid beta-Peptides; D004338:Drug Combinations; D008670:Metals; D010446:Peptide Fragments; C078592:amyloid beta-protein (1-40)