title: A richness that cures.
abstract: A study in Nature by Fischer et al. shows that environmental enrichment or increasing histone acetylation rescue the ability to form new memories and re-establish access to remote memories even in the presence of brain degeneration. Chromatin remodeling may be the final gate environmental enrichment opens to enhance plasticity and represents a promising target for therapeutical intervention in neurodegenerative diseases.
authors.affiliation: Scuola Normale Superiore, Pisa, Italy.
authors.forename: Tommaso
authors.initials: T
authors.lastname: Pizzorusso
authors.forename: Nicoletta
authors.initials: N
authors.lastname: Berardi
authors.forename: Lamberto
authors.initials: L
authors.lastname: Maffei
mesh_terms: D000107:Acetylation; D000818:Animals; D001522:Behavior, Animal; D042002:Chromatin Assembly and Disassembly; D004777:Environment; D006657:Histones / Q000378:metabolism*; D008568:Memory / Q000502:physiology; D051379:Mice; D019636:Neurodegenerative Diseases / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy; D009473:Neuronal Plasticity
chemical_list: D006657:Histones