Novel potential drug against T. cruzi and its interaction with surfactant micelles.
The interaction of 5-nitro-2-furfurilylidene benzhydrazide (5NFB), potential anti-trypanosomal compound, with micellar solutions was studied. The results indicated that 50 mug of 5NFB completely kills 20 million T. cruzi epimastigote cells within 3 days, whereas the same amount of benznidazole kills 30% of the cells after 4 days. 5NFB solubility in surfactants solutions (SDS, DTAB, C12EO8) increased linearly with surfactant concentration. According to small angle X-ray scattering (SAXS), 5NFB does not affect micellar structural features. A comparison between C12EO8 effects on T. cruzi epimastigote cells and on erythrocytes showed that surfactant lytic effect is stronger in parasite cells, enlightening the potential of 5NFB micellar formulations.
Rangel-Yagui
Carlota O
CO
Department of Biochemical and Pharmaceutical Technology, Faculty of Pharmacy, University of São Paulo, São Paulo, Brazil. corangel@usp.br
Hsu
Helen W L
HW
Barbosa
Leandro R S
LR
Caetano
Wilker
W
Pessoa
Adalberto
A
Tavares
Leoberto C
LC
Itri
Rosangela
R
D000818:Animals; D014355:Chagas Disease / Q000188:drug therapy; D004912:Erythrocytes / Q000187:drug effects; D006461:Hemolysis / Q000187:drug effects; D006835:Hydrazones / Q000737:chemistry / Q000494:pharmacology*; D008823:Micelles; D009581:Nitrofurans / Q000737:chemistry / Q000494:pharmacology*; D009593:Nitroimidazoles / Q000494:pharmacology; D053838:Scattering, Small Angle; D012756:Sheep; D012995:Solubility; D013501:Surface-Active Agents / Q000737:chemistry*; D014344:Trypanocidal Agents / Q000737:chemistry / Q000494:pharmacology*; D014349:Trypanosoma cruzi / Q000187:drug effects*; D014961:X-Ray Diffraction
C522160:5-nitro-2-furfurilylidene benzhydrazide; D006835:Hydrazones; D008823:Micelles; D009581:Nitrofurans; D009593:Nitroimidazoles; D013501:Surface-Active Agents; D014344:Trypanocidal Agents; C009999:benzonidazole