gyrA and parC Mutations and associated quinolone resistance in Vibrio anguillarum serotype O2b strains isolated from farmed Atlantic cod (Gadus morhua) in Norway.
MIC testing of Vibrio anguillarum isolates recovered from diseased farmed Atlantic cod revealed oxolinic acid MICs of < or =0.001, 0.06, and 16 microg ml(-1). Single gyrA Ser-Ile substitutions were identified at position 83 of the intermediate and resistant strains, while a parC Ser-Leu substitution at position 85 was found only in the resistant strain.
Colquhoun
D J
DJ
National Veterinary Institute, Section for Fish Health, Ullevaalsveien 68, Oslo 0454, Norway. duncan.colquhoun@vetinst.no
Aarflot
L
L
Melvold
C F
CF
D000818:Animals; D001483:Base Sequence; D027081:DNA Gyrase / Q000235:genetics*; D027101:DNA Topoisomerase IV / Q000235:genetics*; D024881:Drug Resistance, Bacterial; D005393:Fish Diseases / Q000382:microbiology; D005398:Fisheries; D048389:Gadus morhua / Q000382:microbiology*; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D009154:Mutation; D009664:Norway / Q000453:epidemiology; D015363:Quinolones / Q000494:pharmacology*; D012703:Serotyping; D014733:Vibrio / Q000145:classification / Q000187:drug effects / Q000201:enzymology / Q000235:genetics* / Q000302:isolation & purification; D014735:Vibrio Infections / Q000188:drug therapy / Q000382:microbiology / Q000662:veterinary
D015363:Quinolones; D027101:DNA Topoisomerase IV; D027081:DNA Gyrase