Two ABC transporter operons and the antimicrobial resistance gene mtrF are pilT responsive in Neisseria gonorrhoeae.
Retraction of type IV pili is mediated by PilT. We show that loss of pilT function leads to upregulation of mtrF (multiple transferable resistance) and two operons encoding putative ABC transporters in Neisseria gonorrhoeae MS11. This effect occurs indirectly through the transcriptional regulator FarR, which until now has been shown to regulate only farAB. L-Glutamine can reverse pilT downregulation of the ABC transporter operons and mtrF.
Friedrich
Alexandra
A
Department of Molecular Microbiology and Immunology, L220, Oregon Health Sciences University, Portland, Oregon 97201-3098, USA. friedrich@mpiib-berlin.mpg.de
Arvidson
Cindy G
CG
Shafer
William M
WM
Lee
Eun-Hee
EH
So
Magdalene
M
D018528:ATP-Binding Cassette Transporters / Q000235:genetics*; D000251:Adenosine Triphosphatases / Q000235:genetics / Q000502:physiology*; D001426:Bacterial Proteins / Q000235:genetics* / Q000502:physiology; D024881:Drug Resistance, Bacterial / Q000235:genetics; D015964:Gene Expression Regulation, Bacterial / Q000187:drug effects; D005973:Glutamine / Q000494:pharmacology; D020409:Molecular Motor Proteins / Q000235:genetics / Q000502:physiology*; D009344:Neisseria gonorrhoeae / Q000187:drug effects / Q000235:genetics*; D009876:Operon; D014158:Transcription, Genetic / Q000187:drug effects
D018528:ATP-Binding Cassette Transporters; D001426:Bacterial Proteins; D020409:Molecular Motor Proteins; D005973:Glutamine; D000251:Adenosine Triphosphatases