title: Evidence mounts for a role of the kidney in lipoprotein(a) catabolism.
abstract: Numerous studies have suggested a role of the kidney in lipoprotein(a) (Lp(a)) catabolism, but direct evidence is still lacking. Frischmann et al. demonstrate that the marked elevation of Lp(a) observed in hemodialysis patients results from a decrease in Lp(a) clearance rather than an increase in Lp(a) production, consistent with the notion that the kidney degrades Lp(a). More studies are needed to prove the biological relevance.
authors.affiliation: Northwest Lipid Metabolism and Diabetes Research Laboratories, Department of Medicine, University of Washington, Seattle, Washington 98109, USA.
authors.forename: J J
authors.initials: JJ
authors.lastname: Albers
authors.forename: M L
authors.initials: ML
authors.lastname: Koschinsky
authors.forename: S M
authors.initials: SM
authors.lastname: Marcovina
mesh_terms: D006801:Humans; D007668:Kidney / Q000378:metabolism*; D017270:Lipoprotein(a) / Q000378:metabolism*; D008660:Metabolism / Q000502:physiology; D006435:Renal Dialysis
chemical_list: D017270:Lipoprotein(a)