[The effects of desensitization of capsaicin-sensitive neurons on the blood flow in microvessels of the rat gastric serous muscular membrane with normal and insufficient contents of glucocorticoids].
The effects of desensitization of capsaicin-sensitive neurons on the blood flow velocity in microvessels of the gastric muscular membrane were investigated before and after indomethacin (35 mg/kg) administration in adrenalectomized rats with or without corticosterone replacement (4 mg/kg sc) and in sham-operated animals. Desensitization of capsaicin-sensitive neurons was performed with neurotoxic dose of capsaicin (20 + 30 + 50 mg/kg sc) two weeks before the experiment. Adrenalectomy was created one week before the experiment. The in vivo microscopy technique for direct visualization of gastric microcirculation and analysis of red blood cell (RBC) velocity was employed. Indomethacin decreased the RBC velocity. Adrenalectomy by itself profoundly decreased the RBC velocity, whereas corticosterone replacement prevented this effect. Desensitization of capsaicin-sensitive neurons did not influence the RBC velocity in sham-adrenalectomized rats; however, it induced further fall of both basal and indomethacin-induced RBC velocity in adrenalectomized rats that was prevented by corticosterone. We conclude that glucocorticoid hormones have a beneficial effect on the blood flow velocity in microvessels of the gastric muscular membrane in rats with desensitization of capsaicin-sensitive neurons.
Bobryshev
P Iu
PIu
Podvigina
T T
TT
Mal'tsev
N A
NA
Levkovich
Iu I
IuI
Filaretova
L P
LP
D000315:Adrenalectomy; D000818:Animals; D001783:Blood Flow Velocity; D002211:Capsaicin / Q000008:administration & dosage / Q000494:pharmacology*; D003345:Corticosterone / Q000627:therapeutic use*; D005938:Glucocorticoids / Q000172:deficiency / Q000627:therapeutic use*; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D008833:Microcirculation / Q000187:drug effects / Q000502:physiology; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012704:Serous Membrane / Q000098:blood supply* / Q000294:innervation; D013270:Stomach / Q000098:blood supply* / Q000294:innervation
D005938:Glucocorticoids; D002211:Capsaicin; D003345:Corticosterone; D007213:Indomethacin