[Clinical characteristics, diagnosis and treatment of hepatoid adenocarcinoma of the stomach].
OBJECTIVE
To investigate the clinical characteristics,diagnosis and treatment of hepatoid adenocarcinoma of the stomach.


METHODS
Clinical data of 13 hepatoid adenocarcinomas of the stomach, collected from 201 cases of gastric cancer, were analyzed retrospectively.


RESULTS
Of the 201 gastric carcinomas, there were 13 AFP-producing adenocarcinomas of the stomach, the positive rate was 6.5%. Morphologically, the tumor cells formed glandular, medullary and linear structures. Of the 13 hepatoid adenocarcinomas of the stomach, 10 cases were in gastric antrum and 10 cases were poorly differentiated. The metastasis rates of liver and lymph node in hepatoid adenocarcinoma of stomach were higher than those in non-hepatoid adenocarcinoma of stomach. The treatment of hepatoid adenocarcinoma of stomach depended mainly on radical resection, and adjuvant chemotherapy was needed.The prognosis of hepatoid adenocarcinoma of stomach was poor.


CONCLUSIONS
Hepatoid adenocarcinoma of the stomach has its own special tumor biological behavior and poor prognosis. Special attention should be paid to this disease.
Yang
Chun-kang
CK
Department of Oncological Surgery, The First Afilliated Hospital, Fujian Medical University, Fuzhou 350005, China. chunkang129@yahoo.com.cn
Zhao
Wen-jin
WJ
Dai
Qi-bao
QB
Zhang
Hui-hao
HH
Zheng
Wei
W
D000230:Adenocarcinoma / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017024:Chemotherapy, Adjuvant; D005260:Female; D005743:Gastrectomy; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy*; D000509:alpha-Fetoproteins / Q000378:metabolism
D000509:alpha-Fetoproteins