Depside salts from Salvia miltiorrhiza improve myocardial microperfusion in rats using laser Doppler flowmetry.
OBJECTIVE
To investigate the effects of depside salts from Salvia miltiorrhiza on myocardial microperfusion and systemic hemodynamics in open-chest anaesthetized Sprague-Dawley rats.


METHODS
Myocardial microperfusion was measured by laser Doppler flowmetry with a needle probe; cardiac output (CO) was determined using ultrasonic Doppler flowmetry. Other hemodynamic parameters, including femoral artery blood pressure, cardiac inotropy, and systemic vascular resistance (SVR) were simultaneously recorded by the PowerLab system.


RESULTS
Intravenous administration of S miltiorrhiza depside salts resulted in a significant immediate increase in CO and cardiac inotropy, but a fall in SVR. S miltiorrhiza depside salts (30 mg/kg and 60 mg/kg) promoted cardiac index (CI) by 12.2%+/-6.3% (P<0.01 vs baseline) and 20.1%+/-3.5% (P<0.01), respectively. Myocardial microperfusion maximally increased by 6.3%+/-2.9% (P<0.01) and 9.6%+/-4.0% (P<0.01) for 30 mg/kg and 60 mg/kg S miltiorrhiza depside salts, respectively.


CONCLUSIONS
These results indicated that S miltiorrhiza depside salts improved myocardial micro-perfusion, as well as CO.
Li
Xiao-Fen
XF
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, China.
Wang
Yi-Ping
YP
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D053630:Depsides / Q000737:chemistry / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000494:pharmacology; D006439:Hemodynamics / Q000187:drug effects*; D017078:Laser-Doppler Flowmetry; D008297:Male; D015394:Molecular Structure; D009206:Myocardium / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D027561:Salvia miltiorrhiza / Q000737:chemistry*
D053630:Depsides; D004365:Drugs, Chinese Herbal