Potential role of thiol:disulfide oxidoreductases in the pathogenesis of Helicobacter pylori.
Helicobacter pylori infections are responsible for a sequence of molecular events which ultimately result in the development of gastric diseases. The pathogenesis of H. pylori has been studied extensively with strong focus on the identification of virulence factors. In contrast, the involvement of thiol:disulfide oxidoreductases in bacterial pathogenesis is less well understood. This paper provides a review of the current knowledge of H. pylori putative thiol:disulfide oxidoreductases, and their potential role in promoting virulence and colonization. Several bioinformatic analyses served to complete the information on these oxidoreductases of H. pylori.
Kaakoush
Nadeem O
NO
School of Medical Sciences, The University of New South Wales, Sydney, Australia.
Kovach
Zsuzsanna
Z
Mendz
George L
GL
D001426:Bacterial Proteins / Q000502:physiology*; D016481:Helicobacter Infections / Q000382:microbiology*; D016480:Helicobacter pylori / Q000201:enzymology* / Q000472:pathogenicity*; D006801:Humans; D011490:Protein Disulfide Reductase (Glutathione) / Q000502:physiology*; D014774:Virulence; D037521:Virulence Factors / Q000502:physiology*
D001426:Bacterial Proteins; D037521:Virulence Factors; D011490:Protein Disulfide Reductase (Glutathione)