title: Variation in FTO contributes to childhood obesity and severe adult obesity.
abstract: We identified a set of SNPs in the first intron of the FTO (fat mass and obesity associated) gene on chromosome 16q12.2 that is consistently strongly associated with early-onset and severe obesity in both adults and children of European ancestry with an experiment-wise P value of 1.67 x 10(-26) in 2,900 affected individuals and 5,100 controls. The at-risk haplotype yields a proportion of attributable risk of 22% for common obesity. We conclude that FTO contributes to human obesity and hence may be a target for subsequent functional analyses.
authors.affiliation: CNRS 8090-Institute of Biology, Pasteur Institute, Lille, France. dina@good.ibl.fr
authors.forename: Christian
authors.initials: C
authors.lastname: Dina
authors.forename: David
authors.initials: D
authors.lastname: Meyre
authors.forename: Sophie
authors.initials: S
authors.lastname: Gallina
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Durand
authors.forename: Antje
authors.initials: A
authors.lastname: Körner
authors.forename: Peter
authors.initials: P
authors.lastname: Jacobson
authors.forename: Lena M S
authors.initials: LM
authors.lastname: Carlsson
authors.forename: Wieland
authors.initials: W
authors.lastname: Kiess
authors.forename: Vincent
authors.initials: V
authors.lastname: Vatin
authors.forename: Cecile
authors.initials: C
authors.lastname: Lecoeur
authors.forename: Jérome
authors.initials: J
authors.lastname: Delplanque
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Vaillant
authors.forename: François
authors.initials: F
authors.lastname: Pattou
authors.forename: Juan
authors.initials: J
authors.lastname: Ruiz
authors.forename: Jacques
authors.initials: J
authors.lastname: Weill
authors.forename: Claire
authors.initials: C
authors.lastname: Levy-Marchal
authors.forename: Fritz
authors.initials: F
authors.lastname: Horber
authors.forename: Natascha
authors.initials: N
authors.lastname: Potoczna
authors.forename: Serge
authors.initials: S
authors.lastname: Hercberg
authors.forename: Catherine
authors.initials: C
authors.lastname: Le Stunff
authors.forename: Pierre
authors.initials: P
authors.lastname: Bougnères
authors.forename: Peter
authors.initials: P
authors.lastname: Kovacs
authors.forename: Michel
authors.initials: M
authors.lastname: Marre
authors.forename: Beverley
authors.initials: B
authors.lastname: Balkau
authors.forename: Stéphane
authors.initials: S
authors.lastname: Cauchi
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Chèvre
authors.forename: Philippe
authors.initials: P
authors.lastname: Froguel
mesh_terms: D050154:Adiposity; D000328:Adult; D017668:Age of Onset; D001823:Body Composition; D015992:Body Mass Index; D016022:Case-Control Studies; D002648:Child; D002885:Chromosomes, Human, Pair 16 / Q000235:genetics*; D015331:Cohort Studies; D005060:Europe; D005260:Female; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation / Q000235:genetics; D006801:Humans; D007438:Introns / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*