title: [Effects of Rhaponticum uniforum polysaccharide on immune response of mice after antigen stimulation and their possible mechanisms].
abstract: OBJECTIVE
  To study the effects of Rhaponticum uniforum polysaccharide on immune function in normal mice and the underlying mechanism.
  
  
  METHODS
  SRBC and ovalbumin were employed as antigens to be injected to mice, respectively. Three doses of R. uniforum polysaccharide (50, 100, 200 mg x kg(-1) x d(-1)) were given orally for seven days. After the secondary immunization, the level of corresponding antibody and the concentration of serum IL-2, IFN-gamma were determined.
  
  
  RESULTS
  The levels of antibodies (anti-SRBC and anti-ovalbumin) and cytokines (IL-2 and IFN-gamma) in median dose group of R. uniforum polysaccharide were all significantly higher than those in control groups (P <0.05).
  
  
  CONCLUSIONS
  R. uniforum polysaccharide could enhance the immune function in normal mice.
authors.affiliation: College of Clinical Laboratory, Dalian Medical University, Dalian 116027, China.
authors.forename: Fa-Sheng
authors.initials: FS
authors.lastname: Li
authors.forename: Guang
authors.initials: G
authors.lastname: Yang
authors.forename: Feng
authors.initials: F
authors.lastname: Xian
authors.forename: Hui
authors.initials: H
authors.lastname: Liu
mesh_terms: D000818:Animals; D000906:Antibodies / Q000276:immunology*; D000917:Antibody Formation / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000276:immunology; D007371:Interferon-gamma / Q000097:blood; D007376:Interleukin-2 / Q000097:blood; D043843:Leuzea / Q000737:chemistry*; D008297:Male; D051379:Mice; D010047:Ovalbumin / Q000276:immunology; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D011134:Polysaccharides / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D011897:Random Allocation; D012756:Sheep
chemical_list: D000906:Antibodies; D007376:Interleukin-2; D011134:Polysaccharides; D007371:Interferon-gamma; D010047:Ovalbumin