Immune responses against measles virus in cynomolgus monkeys.
Measles virus (MV) induces profound suppression of the immune response during and for weeks after acute infection. On the other hand, virus-specific immune responses that mediate viral clearance and confer long-lasting immunity are efficiently generated. To investigate this paradox, we studied the immune responses to MV using a monkey model of acute measles. Cynomolgus monkeys were experimentally infected with wild-type MV (MV-HL) and showed marked leukopenia associated with a steady reduction in CD4+ T cell numbers for 18 days post-inoculation. Transient expression of interferon and IL-6 were observed in the serum between 4 and 6 days post-inoculation, and IL-10 levels increased after 11 days post-inoculation. Interestingly, IL-8 showed a three-peak increase that correlated with an increase in neutrophils. A non-human primate model of measles allows the early immune response against MV to be studied in more detail.
Sato
Hiroki
H
Laboratory Animal Research Center, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.
Kobune
Fumio
F
Ami
Yasushi
Y
Yoneda
Misako
M
Kai
Chieko
C
D000818:Animals; D016207:Cytokines / Q000378:metabolism; D008252:Macaca fascicularis / Q000276:immunology*; D008457:Measles / Q000276:immunology* / Q000821:virology*; D008459:Measles virus / Q000276:immunology*; D009504:Neutrophils / Q000378:metabolism; D016176:T-Lymphocyte Subsets / Q000276:immunology / Q000378:metabolism; D013997:Time Factors
D016207:Cytokines