title: Primary Ewing sarcoma/PNET of the kidney: fine-needle aspiration, histology, and dual color break apart FISH Assay.
abstract: A 34-year-old previously healthy Hispanic man presented with lower back pain. CT scan revealed an 8-cm space-occupying lesion in the superior pole of the left kidney with numerous small lytic lesions in the skull, vertebrae, ribs, and pelvic bones. CT-guided fine-needle aspiration biopsy revealed a high-grade primitive small round cell tumor with the tumor cells being strongly positive for CD99 and vimentin. The patient subsequently underwent a left nephrectomy. Fluorescence in situ hybridization analysis using a DNA probe for the Ewing Sarcoma breakpoint region 1 (EWSR1) on chromosome 22g12 revealed a rearrangement of the EWSR1 locus. The diagnosis of primary Ewing sarcoma/primitive neuroectodermal tumor of the kidney was established.
authors.affiliation: Department of Pathology, New York University Medical Center, New York, New York, USA.
authors.forename: Steven H
authors.initials: SH
authors.lastname: Kang
authors.forename: Mary Ann
authors.initials: MA
authors.lastname: Perle
authors.forename: Daisuke
authors.initials: D
authors.lastname: Nonaka
authors.forename: Hongfa
authors.initials: H
authors.lastname: Zhu
authors.forename: Wai
authors.initials: W
authors.lastname: Chan
authors.forename: Grace C H
authors.initials: GC
authors.lastname: Yang
mesh_terms: D000328:Adult; D044963:Biopsy, Fine-Needle; D001859:Bone Neoplasms / Q000473:pathology*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence / Q000379:methods*; D007680:Kidney Neoplasms / Q000473:pathology*; D008297:Male; D009392:Nephrectomy; D018241:Neuroectodermal Tumors, Primitive, Peripheral / Q000473:pathology*; D012512:Sarcoma, Ewing / Q000473:pathology*