Lisosan G, a powder of grain, does not interfere with the drug metabolizing enzymes and has a protective role on carbon tetrachloride-induced hepatotoxicity.
Lisosan G is a powder of grain registered as an alimentary integrator. The treatment of rats for 4 days with 0.5 g Lisosan G/kg had no effect on various drug metabolizing enzymes. Experiments in vitro showed that Lisosan G had radical scavenger activity. A confirmation of the antioxidative property of Lisosan G was also confirmed when it was administered in vivo to carbon tetrachloride (CCl(4))-intoxicated rats. The toxicity caused by CCl(4)-treatment of rats was restored to the control levels when the rats were given Lisosan G for 4 days before CCl(4). Lisosan G thus does not interfere with drug metabolizing system but has antioxidant properties and protects against CCl(4)-induced hepatotoxicity.
Longo
Vincenzo
V
Laboratory of Pharmacogenetics and Drug Metabolism, Istituto di Fisiologia Clinica, CNR, via Moruzzi, 1, Pisa, 56100, Italy. v.longo@ifc.cnr.it
Chirulli
Vera
V
Gervasi
Pier Giovanni
PG
Nencioni
Simona
S
Pellegrini
Michela
M
D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000378:metabolism; D001709:Biotechnology / Q000379:methods*; D002251:Carbon Tetrachloride / Q000737:chemistry*; D002252:Carbon Tetrachloride Poisoning / Q000188:drug therapy* / Q000517:prevention & control; D002626:Chemistry, Pharmaceutical / Q000379:methods; D002523:Edible Grain / Q000378:metabolism*; D004798:Enzymes / Q000378:metabolism; D008099:Liver / Q000473:pathology*; D008297:Male; D004364:Pharmaceutical Preparations / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry* / Q000378:metabolism; D028321:Plant Preparations; D020011:Protective Agents / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley
D000975:Antioxidants; D004798:Enzymes; C522933:Lisosan G; D004364:Pharmaceutical Preparations; D010936:Plant Extracts; D028321:Plant Preparations; D020011:Protective Agents; D002251:Carbon Tetrachloride