title: Leukaemia, brain tumours and exposure to extremely low frequency magnetic fields: cohort study of Swiss railway employees.
abstract: OBJECTIVE
  To investigate the relationship between extremely low frequency magnetic field (ELF-MF) exposure and mortality from leukaemia and brain tumour in a cohort of Swiss railway workers.
  
  
  METHODS
  20,141 Swiss railway employees with 464,129 person-years of follow-up between 1972 and 2002 were studied. Mortality rates for leukaemia and brain tumour of highly exposed train drivers (21 muT average annual exposure) were compared with medium and low exposed occupational groups (i.e. station masters with an average exposure of 1 muT). In addition, individual cumulative exposure was calculated from on-site measurements and modelling of past exposures.
  
  
  RESULTS
  The hazard ratio (HR) for leukaemia mortality of train drivers was 1.43 (95% CI 0.74 to 2.77) compared with station masters. For myeloid leukaemia the HR of train drivers was 4.74 (95% CI 1.04 to 21.60) and for Hodgkin's disease 3.29 (95% CI 0.69 to 15.63). Lymphoid leukaemia, non-Hodgkin's disease and brain tumour mortality were not associated with magnetic field exposure. Concordant results were obtained from analyses based on individual cumulative exposure.
  
  
  CONCLUSIONS
  Some evidence of an exposure-response association was found for myeloid leukaemia and Hodgkin's disease, but not for other haematopoietic and lymphatic malignancies and brain tumours.
authors.affiliation: Department of Social and Preventive Medicine, University of Berne, Switzerland. Roeoesli@ispm.unibe.ch
authors.forename: Martin
authors.initials: M
authors.lastname: Röösli
authors.forename: Manfred
authors.initials: M
authors.lastname: Lörtscher
authors.forename: Matthias
authors.initials: M
authors.lastname: Egger
authors.forename: Dominik
authors.initials: D
authors.lastname: Pfluger
authors.forename: Nadja
authors.initials: N
authors.lastname: Schreier
authors.forename: Emanuel
authors.initials: E
authors.lastname: Lörtscher
authors.forename: Peter
authors.initials: P
authors.lastname: Locher
authors.forename: Adrian
authors.initials: A
authors.lastname: Spoerri
authors.forename: Christoph
authors.initials: C
authors.lastname: Minder
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001932:Brain Neoplasms / Q000209:etiology* / Q000401:mortality; D004574:Electromagnetic Fields / Q000009:adverse effects*; D004812:Epidemiologic Methods; D006801:Humans; D007938:Leukemia / Q000209:etiology* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000209:etiology* / Q000401:mortality; D016273:Occupational Exposure / Q000009:adverse effects* / Q000032:analysis; D011890:Railroads; D013557:Switzerland / Q000453:epidemiology