title: [To the mechanism of enhancing the activity of serum and hepatic sorbitol dehydrogenase in rats fed excess sweetener sorbitol].
abstract: One-month rats were randomized to a diet containing sorbitol (SOR) (54%), saccharose (SACCH) (54%) or that containing SOR (27%) and SACCH (27%). They were kept on the diets for 1 or 3 months. At the age of 2 and 4 months, the rats were returned to the routine diet of a vivarium. The experiments were terminated when the rats were aged 2, 4, and 7 months. In all seasons, the monthly diets containing 27% and 54% of SOR increased the serum activity of sortibol dehydrogenase (SDH) by several and tens of times. The 3-month diet produced the same effect. It suddenly turned out that the 54% SACCH diet also increased SDH activity, but to a lesser extent than a combination of 27 SOR and 27% SACCH, and by tens of times less than the 54% SOR diet. Comparison of three diets showed the same relationship between the increases in SDH activity in the liver. With excess dietary SOR, a very high increase was first found in serum and hepatic SOD activity by an induction mechanism.
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Petrovich
authors.forename: A I
authors.initials: AI
authors.lastname: Volozhin
authors.forename: V A
authors.initials: VA
authors.lastname: Zubtsov
authors.forename: N F
authors.initials: NF
authors.lastname: Trusova
authors.forename: S M
authors.initials: SM
authors.lastname: Kachenko
mesh_terms: D000818:Animals; D007064:L-Iditol 2-Dehydrogenase / Q000097:blood / Q000187:drug effects / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D051381:Rats; D012621:Seasons; D013012:Sorbitol / Q000008:administration & dosage / Q000494:pharmacology*; D013395:Sucrose / Q000494:pharmacology; D013549:Sweetening Agents / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D013549:Sweetening Agents; D013012:Sorbitol; D013395:Sucrose; D007064:L-Iditol 2-Dehydrogenase