title: Theoretical and experimental investigations on the size of alginate microspheres prepared by dropping and spraying.
abstract: In order to produce functional microspheres with different ranges of sizes for various applications, the size of alginate droplets prepared by dropping and spraying was studied. It was shown that the mean diameter could be controlled by liquid flow velocity and applied voltage as operating parameters using a conventional dropping and an electrostatic dropping method, separately. The formation mechanism of alginate droplets could be categorized into two different modes: Dripping mode and jetting mode. By employing an effective force analysis, the diameters in each modes showed to be well agreed with the numerical simulation within 7% deviations. It was testified that the initial amount of surface charges had a high impact on droplet diameter and the liquid flow velocity played a more important role on mean diameter of alginate droplets by electrostatic dropping method in dripping mode than in jetting mode. Then, an empirical equation and a semi-empirical model were used to simulate the diameter of droplets obtained by spraying and spraying with electrostatic field (SEF) method, respectively. The decrease in diameter was more sensitive to the increase of gas flow rate than to the decrease of liquid flow rate, and the results of two models fitted well with experimental values. The simulations showed that SEF yielded a 20% lower on droplet diameter than simple spraying method.
authors.affiliation: Department of Bioscience and Biotechnology, School of Environmental and Biological Science and Technology, Dalian University of Technology, Dalian 116024, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Zhang
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Li
authors.forename: Daijia
authors.initials: D
authors.lastname: Zhang
authors.forename: Zhilong
authors.initials: Z
authors.lastname: Xiu
mesh_terms: D000464:Alginates / Q000737:chemistry*; D004355:Drug Stability; D004563:Electrochemistry / Q000379:methods; D008863:Microspheres; D055672:Static Electricity; D013500:Surface Tension; D013594:Syringes; D014783:Viscosity
chemical_list: D000464:Alginates