title: Clearance of hepatitis C virus in HIV-infected patients with multiple chronic viral hepatitis.
abstract: Viral interferences between hepatitis C (HCV) and hepatitis B (HBV) viruses were investigated in a case-control study conducted in 107 human immunodeficiency virus (HIV)-infected patients with HCV antibodies. Overall, 15 (68%) of 22 hepatitis B surface antigen (HBsAg)-positive patients had negative serum HCV-RNA while it occurred in only nine (10%) of 85 HBsAg-negative counterparts (P = 0.02). After adjusting for age, antiretroviral therapy, plasma HIV-RNA and CD4 counts, being HBsAg-positive was strongly associated with having negative serum HCV-RNA (odds ratio: 23; 95% confidence interval: 6-59; P < 0.001). Thus, HBV may favour the elimination of HCV in HIV-infected patients, which may influence liver disease and therapeutic decisions.
authors.affiliation: Department of Infectious Diseases, Hospital Carlos III, Madrid, Spain. luz.martin@inicia.es
authors.forename: L
authors.initials: L
authors.lastname: Martín-Carbonero
authors.forename: P
authors.initials: P
authors.lastname: Barreiro
authors.forename: G
authors.initials: G
authors.lastname: Jiménez-Galán
authors.forename: R
authors.initials: R
authors.lastname: García-Berriguete
authors.forename: M
authors.initials: M
authors.lastname: Núñez
authors.forename: P
authors.initials: P
authors.lastname: Ríos
authors.forename: J
authors.initials: J
authors.lastname: González-Lahoz
authors.forename: V
authors.initials: V
authors.lastname: Soriano
mesh_terms: D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D044966:Anti-Retroviral Agents / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D016022:Case-Control Studies; D005260:Female; D006678:HIV / Q000235:genetics / Q000302:isolation & purification; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D016174:Hepacivirus / Q000235:genetics / Q000302:isolation & purification / Q000502:physiology*; D006514:Hepatitis B Surface Antigens / Q000097:blood; D006515:Hepatitis B virus / Q000502:physiology*; D019694:Hepatitis B, Chronic / Q000097:blood / Q000150:complications*; D018937:Hepatitis C Antibodies / Q000097:blood; D019698:Hepatitis C, Chronic / Q000097:blood / Q000150:complications / Q000821:virology*; D006801:Humans; D008297:Male; D012367:RNA, Viral / Q000097:blood; D012189:Retrospective Studies; D014762:Viral Interference
chemical_list: D044966:Anti-Retroviral Agents; D006514:Hepatitis B Surface Antigens; D018937:Hepatitis C Antibodies; D012367:RNA, Viral; D000410:Alanine Transaminase