Protective Effect of Meso-Tetrakis-(3,5-di-tert-butyl-4-hydroxyphenyl)porphyrin on the In Vivo Impact of Trimethyltin Chloride on the Antioxidative Defense System.
The in vivo effect of trimethyltin chloride (Me(3)SnCl), free base meso-tetrakis(3,5-di-tert-butyl-4-hydroxyphenyl)porphyrin (R'(4)PH(2)) and their equimolar mixture, on the enzymatic activity of catalase (CAT), superoxide dismutase (SOD), and on the total content of free sulfhydryl groups has been studied in rat liver and kidney. It was demonstrated that the simultaneous treatment of tested animals with the combination of Me(3)SnCl and R'(4)PH(2) reduced the toxic impact of Me(3)SnCl.
Milaeva
Elena R
ER
Department of Organic Chemistry, M. V. Lomonosov Moscow State University, Moscow 119992, Russia.
Tyurin
Vladimir Yu
VY
Gracheva
Yulia A
YA
Dodochova
Margarita A
MA
Pustovalova
Lydia M
LM
Chernyshev
Victor N
VN