title: Overcoming opioid blockade from depot naltrexone (Prodetoxon).
abstract: OBJECTIVE
  To describe a situation in which an opioid-dependent patient overcame naltrexone blockade. DESIGN, CASE REPORT, SETTING: Addiction treatment center in St Petersburg, Russia.
  
  
  METHODS
  Patient with naltrexone implant.
  
  
  METHODS
  Detoxification.
  
  
  METHODS
  Clinical observations.
  
  
  CONCLUSIONS
  It is possible, but very difficult, to overcome naltrexone blockade by using large doses of heroin.
authors.affiliation: St Petersburg Regional Center in Addiction and Psychopharmacology affiliated with Pavlov State Medical University, St Petersburg, Russia.
authors.forename: E M
authors.initials: EM
authors.lastname: Kruptisky
authors.forename: A M
authors.initials: AM
authors.lastname: Burakov
authors.forename: M V
authors.initials: MV
authors.lastname: Tsoy
authors.forename: V Y
authors.initials: VY
authors.lastname: Egorova
authors.forename: T Y
authors.initials: TY
authors.lastname: Slavina
authors.forename: A Y
authors.initials: AY
authors.lastname: Grinenko
authors.forename: E E
authors.initials: EE
authors.lastname: Zvartau
authors.forename: G E
authors.initials: GE
authors.lastname: Woody
mesh_terms: D000328:Adult; D004343:Drug Implants / Q000627:therapeutic use*; D006556:Heroin Dependence / Q000188:drug therapy*; D006801:Humans; D008658:Inactivation, Metabolic; D008297:Male; D009271:Naltrexone / Q000493:pharmacokinetics / Q000627:therapeutic use*; D009292:Narcotic Antagonists / Q000493:pharmacokinetics / Q000627:therapeutic use*; D055502:Secondary Prevention; D013375:Substance Withdrawal Syndrome / Q000628:therapy
chemical_list: D004343:Drug Implants; D009292:Narcotic Antagonists; D009271:Naltrexone