Percentage non-caeruloplasmin bound copper.
OBJECTIVE
To compare percentage non-caeruloplasmin bound copper (%NCC) to generally accepted values.


METHODS
Using data for 338 normal individual patients, we calculated the %NCC.


RESULTS
The %NCC ranged (median) from -59.75% to 51.98% (8.75%) respectively. The non-parametric reference interval was -23.44% to 22.99% with 43.8% of the %NCC values >10%.


CONCLUSIONS
We found the %NCC to be higher than generally accepted. This may be due to uncertainty from precision, bias and specificity.
Twomey
Patrick J
PJ
Department of Clinical Biochemistry, The Ipswich Hospital, Heath Road, Ipswich IP4 5PD, UK. patrick.twomey@ipswichhospital.nhs.uk
Wierzbicki
Anthony S
AS
House
Ivan M
IM
Viljoen
Adie
A
Reynolds
Timothy M
TM
D002570:Ceruloplasmin / Q000032:analysis*; D003300:Copper / Q000097:blood*; D006801:Humans; D011485:Protein Binding; D012016:Reference Values
D003300:Copper; D002570:Ceruloplasmin