Role of aldosterone availability in preeclampsia.
Preeclampsia is a hypertensive disorder unique to pregnancy and remains the leading cause of maternal and fetal morbidity and mortality. Despite active research, the etiology of this disease remains still an enigma. There is increasing evidence that a combination of several factors is responsible for the development of preeclampsia. In this review, we discuss the role of aldosterone in the regulation of body fluid in pregnancy and preeclampsia. Aldosterone is produced by the enzyme aldosterone synthase and competes with cortisol and progesterone for the mineralocorticoid receptor, thus affecting sodium reabsorption and maternal volume expansion. Aldosterone seems to play a pivotal role in controlling blood pressure during pregnancy and to contribute to the well-being of the mother-to-be. Novel findings in understanding the underlying causes of preeclampsia provide a rationale for future novel prophylactic and therapeutic interventions in the treatment of this pregnancy-associated disease.
Escher
Geneviève
G
University Hospital of Berne, Division of Nephrology and Hypertension, 3010 Berne, Switzerland. geneviève.escher@dkf.unibe.ch
Mohaupt
Markus
M
D000450:Aldosterone / Q000378:metabolism* / Q000502:physiology; D001794:Blood Pressure; D019405:Cytochrome P-450 CYP11B2 / Q000378:metabolism; D005260:Female; D006801:Humans; D008954:Models, Biological; D011225:Pre-Eclampsia / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D011247:Pregnancy
D000450:Aldosterone; D019405:Cytochrome P-450 CYP11B2