[Impact of bacterial lectin on functional activity of lymphocytes].
Impact of Azospirillum brasilense Sp7 lectin with carbohydrate specificity to L-fucose on T- and B-lymphocytes production, activity of IL-1alpha, and TNF-alpha was studied in vitro and compared with influence of red kidney bean phytohemagglutinin (PHA) on the same parameters. Increase of growth of T- and B-cells subpopulations has been shown that point to stimulatory effect of the bacterial lectin. Bacterial lectin of A. brasilense also increased synthesis of IL-1alpha and TNF-alpha. It has been shown that the bacterial lectin has more pronounced stimulatory effect on functional activity of lymphocytes compared with PHA.
Ponomareva
E G
EG
Emel'ianova
N V
NV
Nikitina
V E
VE
Zakharova
N B
NB
D015806:Azospirillum brasilense; D001402:B-Lymphocytes / Q000187:drug effects / Q000276:immunology; D002455:Cell Division; D002478:Cells, Cultured; D006801:Humans; D053582:Interleukin-1alpha / Q000096:biosynthesis; D037102:Lectins / Q000302:isolation & purification / Q000494:pharmacology*; D008214:Lymphocytes / Q000166:cytology / Q000187:drug effects* / Q000276:immunology; D010835:Phytohemagglutinins / Q000494:pharmacology; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000187:drug effects / Q000276:immunology
D053582:Interleukin-1alpha; D037102:Lectins; D010835:Phytohemagglutinins; D014409:Tumor Necrosis Factor-alpha