title: C-reactive protein before and after weight loss in overweight women with and without polycystic ovary syndrome.
abstract: BACKGROUND
  Polycystic ovary syndrome (PCOS) is associated with reproductive and metabolic abnormalities. It is unknown whether overweight women with and without PCOS achieve similar benefits from weight loss for cardiovascular risk factors.
  
  
  METHODS
  Overweight body mass index-matched women with (n = 15) and without (n = 17) PCOS (weight, 95.3 +/- 17.6 kg; body mass index, 35.6 +/- 5.3 kg/m(2), mean +/- sd) followed an 8-wk weight loss regime.
  
  
  RESULTS
  All subjects had similar reductions in weight (3.9 +/- 3.6 kg, 3.8%, vs. 4.5 +/- 4.1 kg, 4.7%, respectively, for PCOS and non-PCOS), waist circumference, fat mass, triglycerides, free testosterone, and fasting and postprandial insulin. At baseline, C-reactive protein (CRP) between groups was not significantly different (5.5 +/- 3.1 mg/liter for PCOS vs. 4.9 +/- 3.0 mg/liter for non-PCOS). There was a significant interaction between PCOS status and CRP (P = 0.016) such that CRP decreased with weight loss for non-PCOS women (-1.2 +/- 1.8 mg/liter; P = 0.025) but not for PCOS women. For all women, the change in CRP correlated with the change in weight (r = 0.560; P = 0.003), fat mass (r = 0.477; P = 0.016), and postprandial insulin (r = 0.402; P = 0.046). Adiponectin, IL-6, and TNF-alpha were not significantly different between groups before or after weight loss. Only subjects with baseline CRP levels below the median (4.52 mg/liter) showed increases in adiponectin (0.98 +/- 1.3 microg/liter) (P = 0.015) and greater reductions in triglycerides (P = 0.001) with weight loss.
  
  
  CONCLUSIONS
  A 4-5% weight loss improved lipid, glucose, and insulin profiles in women with and without PCOS. This degree of weight loss was not effective in lowering CRP concentrations in PCOS women, suggesting that greater weight loss is required in this group to achieve equivalent cardiovascular benefit to non-PCOS women.
authors.affiliation: Research Centre for Reproductive Health, University of Adelaide, South Australia 5000, Australia. lisa.moran@csiro.au
authors.forename: Lisa J
authors.initials: LJ
authors.lastname: Moran
authors.forename: Manny
authors.initials: M
authors.lastname: Noakes
authors.forename: Peter M
authors.initials: PM
authors.lastname: Clifton
authors.forename: Gary A
authors.initials: GA
authors.lastname: Wittert
authors.forename: Damien P
authors.initials: DP
authors.lastname: Belobrajdic
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Norman
mesh_terms: D052242:Adiponectin / Q000097:blood; D000328:Adult; D000886:Anthropometry; D001823:Body Composition / Q000502:physiology; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism*; D050528:Diet, Carbohydrate-Restricted; D004435:Eating / Q000502:physiology; D005260:Female; D012739:Gonadal Steroid Hormones / Q000097:blood; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D008598:Menstruation / Q000502:physiology; D008875:Middle Aged; D009043:Motor Activity; D009765:Obesity / Q000150:complications / Q000178:diet therapy / Q000378:metabolism*; D011085:Polycystic Ovary Syndrome / Q000150:complications / Q000378:metabolism*; D012907:Smoking; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D015431:Weight Loss / Q000502:physiology*
chemical_list: D052242:Adiponectin; D012739:Gonadal Steroid Hormones; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein