title: Environmental Arsenic Exposure and Urinary 8-OHdG in Arizona and Sonora.
abstract: Although at high levels arsenic exposure is associated with increased cancer incidence, information on the health effects of lower exposure levels is limited. The objective of this study was to determine whether arsenic at concentrations below 40 microg/L in drinking water is associated with increased urinary 8-hydroxydeoxyguanosine (8-OHdG), a biomarker of DNA oxidative damage and repair. Urine samples were collected from 73 nonsmoking adults residing in two communities in Arizona (mean tap water arsenic (microg/L) 4.0 +/- 2.3 and 20.3 +/- 3.7), and 51 subjects in four communities in Sonora, Mexico (mean tap water arsenic (microg/L) ranging from 4.8 +/- 0.1 to 33.3 +/- 0.6). Although urinary arsenic concentration increased with higher exposure in tap water, urinary 8-OHdG concentration did not differ by community within Arizona or Sonora, and was not associated with urinary arsenic concentration. At the exposure levels evaluated in this study, drinking water arsenic was not associated with increased DNA oxidation as measured by urinary 8-OHdG.
authors.affiliation: University of Arizona. Tucson, Arizona, USA. jburgess@u.arizona.edu
authors.forename: Jefferey L
authors.initials: JL
authors.lastname: Burgess
authors.forename: María M
authors.initials: MM
authors.lastname: Meza
authors.forename: Arun B
authors.initials: AB
authors.lastname: Josyula
authors.forename: Gerald S
authors.initials: GS
authors.lastname: Poplin
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Kopplin
authors.forename: Hannah E
authors.initials: HE
authors.lastname: McClellen
authors.forename: Stefan
authors.initials: S
authors.lastname: Stürup
authors.forename: R Clark
authors.initials: RC
authors.lastname: Lantz
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D000328:Adult; D000368:Aged; D001130:Arizona; D001151:Arsenic / Q000032:analysis / Q000652:urine*; D001152:Arsenicals / Q000652:urine; D015415:Biomarkers / Q000652:urine; D002101:Cacodylic Acid / Q000652:urine; D004247:DNA / Q000378:metabolism; D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000652:urine; D004784:Environmental Monitoring; D005260:Female; D006801:Humans; D008297:Male; D008800:Mexico; D008875:Middle Aged; D009262:Nails / Q000737:chemistry; D010084:Oxidation-Reduction; D014874:Water Pollutants, Chemical / Q000032:analysis / Q000652:urine*; D014881:Water Supply / Q000032:analysis
chemical_list: D001152:Arsenicals; D015415:Biomarkers; D014874:Water Pollutants, Chemical; D000080242:8-Hydroxy-2'-Deoxyguanosine; D004247:DNA; D002101:Cacodylic Acid; D003849:Deoxyguanosine; C020300:monomethylarsonic acid; D001151:Arsenic