Characterization of thalidomide using Raman spectroscopy.
Thalidomide is a potent anticancer therapeutic drug whose mechanism of action has not yet been elucidated. In this report, experimental Raman spectroscopy is used to determine and characterize the vibrational frequencies of the drug. These normal modes are then compared to their quantum mechanical counterparts, which have been computed using density functional theory. Upon analysis of the spectra, we found that there was a high level of agreement between the wavenumbers. As such, this spectroscopic technique may be a viable tool for examining the way in which this drug interacts with its target molecules.
Cipriani
Penelope
P
Department of Chemistry, Spelman College, 350 Spelman Lane SW, Campus Box 369, Atlanta, GA 30314, USA. pcipriani@spelman.edu
Smith
Candace Y
CY
D015394:Molecular Structure; D013059:Spectrum Analysis, Raman / Q000379:methods*; D013792:Thalidomide / Q000737:chemistry*
D013792:Thalidomide