Meal fatty acids and postprandial vascular reactivity.
With increasing recognition of the pivotal role of vascular dysfunction in the progression of atherosclerosis, the vasculature has emerged as an important target for dietary therapies. Recent studies have indicated that chronic fatty acid manipulation alters vascular reactivity, when measured after an overnight fast. However, individuals spend a large proportion of the day in the postprandial (non-fasted) state. Several studies have shown that high fat meals can impair endothelial function within 3-4 h, a time period often associated with peak postprandial lipaemia. Although the impact of meal fatty acids on the magnitude and duration of the postprandial lipaemic response has been extensively studied, very little is known about their impact on vascular reactivity after a meal.
Jackson
K G
KG
Hugh Sinclair Unit of Human Nutrition, Department of Food Biosciences, University of Reading, Reading RG6 6AP, UK. k.g.jackson@reading.ac.uk
Armah
C K
CK
Minihane
A M
AM
D001808:Blood Vessels / Q000187:drug effects* / Q000502:physiology*; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology; D004041:Dietary Fats / Q000008:administration & dosage*; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage; D005227:Fatty Acids / Q000008:administration & dosage*; D005395:Fish Oils / Q000008:administration & dosage; D006801:Humans; D006949:Hyperlipidemias / Q000209:etiology / Q000503:physiopathology; D014664:Vasodilation / Q000187:drug effects
D004041:Dietary Fats; D004042:Dietary Fats, Unsaturated; D005227:Fatty Acids; D005395:Fish Oils