Novel linear polymers bearing thiosialosides as pendant-type epitopes for influenza neuraminidase inhibitors.
A conventional synthesis of alpha-thioglycoside of sialic acid as a glycomonomer was accomplished. Radical copolymerization of the glycomonomer with vinyl acetate proceeded smoothly to afford a new class of glycopolymers having thiosialoside residues, in which all protection was removed by a combination of transesterification and saponification to provide a water-soluble thiosialoside cluster. The results of a preliminary study on biological responses against influenza virus neuraminidases using the thiosialoside polymer as a candidate for a neuraminidase inhibitor showed that the glycopolymer has potent inhibitory activity against the neuraminidases.
Matsuoka
Koji
K
Area for Molecular Function, Division of Material Science, Graduate School of Science and Engineering, Saitama University, Sakura, Saitama 338-8570, Japan. koji@fms.saitama-u.ac.jp
Takita
Chiharu
C
Koyama
Tetsuo
T
Miyamoto
Daisei
D
Yingsakmongkon
Sangchai
S
Hidari
Kazuya I P J
KI
Jampangern
Wipawee
W
Suzuki
Takashi
T
Suzuki
Yasuo
Y
Hatano
Ken
K
Terunuma
Daiyo
D
D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D000939:Epitopes / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D019158:N-Acetylneuraminic Acid / Q000737:chemistry / Q000494:pharmacology*; D009439:Neuraminidase / Q000037:antagonists & inhibitors*; D009975:Orthomyxoviridae / Q000201:enzymology*; D011108:Polymers / Q000737:chemistry / Q000494:pharmacology*; D013055:Spectrophotometry, Infrared
D004791:Enzyme Inhibitors; D000939:Epitopes; D011108:Polymers; D009439:Neuraminidase; D019158:N-Acetylneuraminic Acid