title: [Preparation and evaluation of sustained-release microsphere of Sanguis Draconis in vitro].
abstract: OBJECTIVE
  To prepare sustained-release microsphere containing extract of Sanguis Draconis and to measure its dissolution in vitro.
  
  
  METHODS
  Sustained-release microsphere was prepared with polylactic acid (PLA) as carriers using the oil-in-water (O/W) emulsion solvent evaporation method. The powder particle's characteristics of sustainded-release microsphere were evaluated comprehensively, and its dissolution characteristics in vitro were studied.
  
  
  RESULTS
  The microsphere was round and its surface was smooth, drug-loading rate was 21.97% and the entrapment rate was 55.76%, the accumulative release percentage was 76. 71% in 16 hours.
  
  
  CONCLUSIONS
  The sustained release effect of Sanguis Draconis microspheres was formed with potentially wide applications.
authors.affiliation: Department of Inorganic and Physical Chemistry, College of Pharmacy Hebei Medical University, Shijiazhuang 050017, China. ding5622@163.com
authors.forename: Li-Yu
authors.initials: LY
authors.lastname: Ding
authors.forename: Peng-Fei
authors.initials: PF
authors.lastname: Xia
authors.forename: Cai-Qin
authors.initials: CQ
authors.lastname: Yang
authors.forename: Yu-Long
authors.initials: YL
authors.lastname: Lin
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
mesh_terms: D028023:Arecaceae / Q000737:chemistry*; D003692:Delayed-Action Preparations / Q000737:chemistry*; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000302:isolation & purification; D019344:Lactic Acid / Q000737:chemistry; D008863:Microspheres; D010316:Particle Size; D010946:Plants, Medicinal / Q000737:chemistry; D011091:Polyesters; D011108:Polymers / Q000737:chemistry; D015203:Reproducibility of Results; D012116:Resins, Plant / Q000737:chemistry; D013678:Technology, Pharmaceutical / Q000379:methods*
chemical_list: D003692:Delayed-Action Preparations; D004365:Drugs, Chinese Herbal; D011091:Polyesters; D011108:Polymers; D012116:Resins, Plant; D019344:Lactic Acid; C033616:poly(lactide)