title: Highly enantioselective organocatalytic direct aldol reaction in an aqueous medium.
abstract: We have demonstrated that small organic molecules 1 and 2 catalyzed the direct aldol reaction of both acyclic and cyclic ketones with different aldehydes in an excess of water/brine. Excellent enantioselectivities up to >99% and diastereoselectivities up to 99% with very good yields were obtained by using much lower catalyst loadings (0.5 mol %).
authors.affiliation: Deparment of Chemistry, Indian Institute of Technology Kanpur, India 208 016.
authors.forename: Vishnu
authors.initials: V
authors.lastname: Maya
authors.forename: Monika
authors.initials: M
authors.lastname: Raj
authors.forename: Vinod K
authors.initials: VK
authors.lastname: Singh