title: Does local recurrence impact survival in low-grade chondrosarcoma of the long bones?
abstract: We hypothesized local recurrence of Grade 1 chondrosarcoma in the long bones of the extremity negatively influences survival. To explore that notion, we retrospectively reviewed 164 patients treated surgically for Grade 1 chondrosarcoma of the long bones. Local recurrence occurred in 21 (13%) patients. Four patients had progression of tumor grade on recurrence, and six patients had more than one local recurrence. Seven of the 21 patients with local recurrences had metastasis. Six of the 21 patients with local recurrences died secondary to chondrosarcoma. Local recurrence, progression of grade at recurrence, and distant metastases all were associated with a decrease in overall survival. The difference in survival was not apparent until after 5 years and was more pronounced after 10 years. Recurrence may be regarded as a declaration of an aggressive phenotype and should be treated as such.
authors.affiliation: Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN 55901, USA.
authors.forename: Joseph H
authors.initials: JH
authors.lastname: Schwab
authors.forename: Doris
authors.initials: D
authors.lastname: Wenger
authors.forename: Krishnan
authors.initials: K
authors.lastname: Unni
authors.forename: Franklin H
authors.initials: FH
authors.lastname: Sim
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001859:Bone Neoplasms / Q000175:diagnosis / Q000401:mortality* / Q000601:surgery; D002648:Child; D002675:Child, Preschool; D002813:Chondrosarcoma / Q000175:diagnosis / Q000401:mortality* / Q000601:surgery; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008910:Minnesota / Q000453:epidemiology; D009364:Neoplasm Recurrence, Local / Q000401:mortality*; D012189:Retrospective Studies; D015996:Survival Rate