Distribution of CCR2 polymorphism in HIV-1-infected and healthy subjects in North India.
Substitution of V64I in CCR2 relates to delayed progression to AIDS and protects against HIV-1 infection. We examined the distribution of V64I in HIV-infected and healthy North Indian subjects. No significant difference in the allele or genotype distribution of CCR2 V64I polymorphism was observed, indicating that there is no association between CCR2 V64I polymorphism and susceptibility to HIV infection in North Indian population.
Kaur
G
G
Department of Transplant Immunology and Immunogenetics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India.
Singh
P
P
Kumar
N
N
Rapthap
C C
CC
Sharma
G
G
Vajpayee
M
M
Wig
N
N
Sharma
S K
SK
Mehra
N K
NK
D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D005787:Gene Frequency; D005838:Genotype; D015658:HIV Infections / Q000453:epidemiology / Q000235:genetics*; D015497:HIV-1; D006801:Humans; D007194:India / Q000453:epidemiology; D008875:Middle Aged; D011110:Polymorphism, Genetic; D054390:Receptors, CCR2; D019707:Receptors, Chemokine / Q000235:genetics*
C515334:CCR2 protein, human; D054390:Receptors, CCR2; D019707:Receptors, Chemokine