title: Cytotoxic dibromotyrosine-derived metabolites from the sponge Aplysina gerardogreeni.
abstract: The chemical study of the sponge Aplysina gerardogreeni collected at the Gulf of California has led to the isolation of four new dibromotyrosine-derived metabolites, aplysinones A-D, whose structures were determined by spectroscopic analysis and chemical methods. The new compounds and four semisynthetic analogues prepared in this study have shown cytotoxic activity against human tumor cell lines.
authors.affiliation: Departamento de Química Orgánica, Facultad de Ciencias del Mar y Ambientales, Universidad de Cádiz, Apdo. 40, 11510-Puerto Real (Cádiz), Spain.
authors.forename: Claudia J
authors.initials: CJ
authors.lastname: Hernández-Guerrero
authors.forename: Eva
authors.initials: E
authors.lastname: Zubía
authors.forename: María J
authors.initials: MJ
authors.lastname: Ortega
authors.forename: J Luis
authors.initials: JL
authors.lastname: Carballo
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D045744:Cell Line, Tumor; D006801:Humans; D011161:Porifera / Q000378:metabolism*; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000378:metabolism*
chemical_list: D000970:Antineoplastic Agents; D014443:Tyrosine