title: Solid state characterization of progesterone in a freeze dried 1:2 progesterone/HPBCD mixture.
abstract: Progesterone rapidly dissolves in an aqueous solution containing hydroxypropyl-beta-cyclodextrin (HPBCD) at 1:2 molar ratio, forming a soluble inclusion complex. After filtration and freeze-drying of the final solution, the final powder was examined by SEM, DSC, TGA, XRD, Raman, and FTIR spectroscopy. Experimental results confirm that an inclusion complex exists in the solid state and possible structure of the complex is briefly discussed.
authors.affiliation: IBSA, Institut Biochimique, Lugano, Switzerland.
authors.forename: Giorgio
authors.initials: G
authors.lastname: Zoppetti
authors.forename: Nadia
authors.initials: N
authors.lastname: Puppini
authors.forename: Francesca
authors.initials: F
authors.lastname: Ospitali
authors.forename: Adamo
authors.initials: A
authors.lastname: Fini
mesh_terms: D000073738:2-Hydroxypropyl-beta-cyclodextrin; D002152:Calorimetry, Differential Scanning; D002626:Chemistry, Pharmaceutical; D018360:Crystallography, X-Ray; D004355:Drug Stability; D005079:Excipients / Q000737:chemistry*; D005612:Freeze Drying; D008855:Microscopy, Electron, Scanning; D011208:Powders; D011374:Progesterone / Q000737:chemistry*; D011372:Progestins / Q000737:chemistry*; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D013059:Spectrum Analysis, Raman; D013678:Technology, Pharmaceutical / Q000379:methods*; D013818:Thermogravimetry; D014462:Ultrafiltration; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D005079:Excipients; D011208:Powders; D011372:Progestins; D047392:beta-Cyclodextrins; D000073738:2-Hydroxypropyl-beta-cyclodextrin; D011374:Progesterone