title: Heritability of EEG coherence in a large sib-pair population.
abstract: The additive genetic heritability of bipolar EEG coherence in a sample of 305 non-twin sibships comprising 690 individuals (age range 7-65) was estimated. Heritabilities were examined in 6 frequency bands for each of 15 coherence pairs, both interhemispheric and intrahemispheric. The heritabilities of the bipolar EEG coherence ranged from 0.22 to 0.63 in 79 of the 90 phenotypes which had coherences high enough to provide meaningful values for the estimation of heritability. Heritabilities were greatest in the low and high alpha frequency bands, while theta and beta bands had comparable heritabilities. Coherences themselves were greatest in the low and high alpha frequency bands, while theta coherences were somewhat larger than beta. Higher heritability values were not associated with higher coherences. The examination of bivariate genetic correlations suggests that there is a difference between theta and alpha bands in genetic control of interhemispheric coherence.
authors.affiliation: Henri Begleiter Neurodynamics Laboratory, Department of Psychiatry, SUNY Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY, USA. David.Chorlian@downstate.edu
authors.forename: David B
authors.initials: DB
authors.lastname: Chorlian
authors.forename: Yongqiang
authors.initials: Y
authors.lastname: Tang
authors.forename: Madhavi
authors.initials: M
authors.lastname: Rangaswamy
authors.forename: Sean
authors.initials: S
authors.lastname: O'Connor
authors.forename: John
authors.initials: J
authors.lastname: Rohrbaugh
authors.forename: Robert
authors.initials: R
authors.lastname: Taylor
authors.forename: Bernice
authors.initials: B
authors.lastname: Porjesz
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000437:Alcoholism / Q000235:genetics* / Q000503:physiopathology; D000513:Alpha Rhythm; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000503:physiopathology; D002648:Child; D003344:Cortical Synchronization; D004292:Dominance, Cerebral / Q000235:genetics / Q000502:physiology; D004569:Electroencephalography; D005260:Female; D005625:Frontal Lobe / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D035781:Siblings; D013702:Temporal Lobe / Q000503:physiopathology