[Three advanced gastric cancer patients successfully treated by combination therapy of paclitaxel and cisplatin].
We report 3 gastric cancer patients with peritoneal dissemination who were successfully treated with weekly paclitaxel and cisplatin. The patients were 2 men and 1 woman from 57 to 70 years in age. The histological types were 2 poorly-differentiated adenocarcinomas and 1 moderately-differentiated adenocarcinoma. Intravenous infusion of PTX (80 mg/m(2)) and CDDP (25 mg/m(2)) after short premedication was continued for 3 weeks followed by 1 week rest. Ascites improved only after administration of 1 course in all patients.PTX/CDDP is thought to be an effective chemotherapy showing acceptable toxicity against advanced gastric cancer with ascites.
Yamada
Takeshi
T
Dept. of Surgery, Nippon Medical School, Chiba Hokusou Hospital.
Tanaka
Noritake
N
Yokoi
Kimiyoshi
K
Ishikawa
Noriyuki
N
Seya
Tomoko
T
Horiba
Kouji
K
Kanazawa
Yoshikazu
Y
Shirakawa
Takashi
T
Ohkawa
Keiichi
K
Kudoh
Hidenori
H
Koizumi
Michihiro
M
Yoshioka
Masato
M
Shinji
Seiichi
S
Katsuta
Miwako
M
Yamashita
Kiyohiko
K
Tajiri
Takashi
T
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000556:secondary; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007970:Leukopenia / Q000139:chemically induced; D008297:Male; D008875:Middle Aged; D017239:Paclitaxel / Q000008:administration & dosage; D010534:Peritoneal Neoplasms / Q000188:drug therapy / Q000556:secondary; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology
D017239:Paclitaxel; D002945:Cisplatin