title: PCR-restriction fragment length polymorphism analysis of Campylobacter jejuni genes involved in lipooligosaccharide biosynthesis identifies putative molecular markers for Guillain-Barré syndrome.
abstract: Molecular mimicry of Campylobacter jejuni lipooligosaccharides (LOS) by gangliosides in peripheral nerve tissue probably triggers the Guillain-Barré syndrome due to the induction of cross-reactive antibodies. PCR-restriction fragment length polymorphism analysis of C. jejuni genes involved in the biosynthesis of LOS demonstrated that specific genes were associated with the expression of ganglioside mimics and the development of neuropathy.
authors.affiliation: Department of Medical Microbiology and Infectious Diseases, Erasmus MC, Rotterdam, The Netherlands. p.godschalk@erasmusmc.nl
authors.forename: Peggy C R
authors.initials: PC
authors.lastname: Godschalk
authors.forename: Alex
authors.initials: A
authors.lastname: van Belkum
authors.forename: Nicole
authors.initials: N
authors.lastname: van den Braak
authors.forename: Diana
authors.initials: D
authors.lastname: van Netten
authors.forename: C Wim
authors.initials: CW
authors.lastname: Ang
authors.forename: Bart C
authors.initials: BC
authors.lastname: Jacobs
authors.forename: Michel
authors.initials: M
authors.lastname: Gilbert
authors.forename: Hubert P
authors.initials: HP
authors.lastname: Endtz
mesh_terms: D000907:Antibodies, Bacterial / Q000276:immunology*; D015415:Biomarkers; D016123:Campylobacter jejuni / Q000235:genetics*; D003429:Cross Reactions; D015964:Gene Expression Regulation, Bacterial; D020275:Guillain-Barre Syndrome / Q000276:immunology*; D006801:Humans; D008070:Lipopolysaccharides / Q000096:biosynthesis* / Q000276:immunology; D018716:Molecular Mimicry; D016133:Polymerase Chain Reaction / Q000379:methods*; D012150:Polymorphism, Restriction Fragment Length
chemical_list: D000907:Antibodies, Bacterial; D015415:Biomarkers; D008070:Lipopolysaccharides; C023023:lipid-linked oligosaccharides