Do single seizures cause neuronal death in the human hippocampus?
The question of whether repeated single seizures cause neuronal death in the adult human brain is of great clinical importance and might have broad therapeutic implications. Reviewed here are recent studies on the effects of repeated single seizures (in the absence of status epilepticus) on hippocampal volume and on neuronal death markers in blood and in surgically ablated hippocampi.
Rocha
Luisa L
LL
Pharmacobiology Department, Center for Research and Advanced Studies, Mexico City, Mexico.
Lopez-Meraz
Maria-Leonor
ML
Niquet
Jerome
J
Wasterlain
Claude G
CG