Association of secondary sex ratio with smoking and parity.
OBJECTIVE
To assess the sex ratio in offspring of smoking and nonsmoking mothers in relationship to parity.


METHODS
Prospective study.


METHODS
University hospital.


METHODS
The authors studied 2,108 term singleton neonates born between 1993 and 2002, 665 from smoking mothers and 1,443 from nonsmoking mothers.


METHODS
A prospective recording of maternal age, parity and smoking status, and gender of neonates delivered over a 10-year period.


METHODS
Secondary sex ratio in regard to maternal smoking and parity.


RESULTS
The offspring sex ratio in the total sample studied was 1.09; in the offspring of smoking and nonsmoking mothers, it was 1.26 and 1.03, respectively, a statistically significant difference. In the offspring of smoking women who had parity 1, 2, and >or=3, it was 1.47, 1.35, and 0.92, whereas in those of nonsmoking women, it was 1.04, 1.00, and 1.03, respectively (the differences of the parity 1 and 2 groups between the offspring of smoking and nonsmoking mothers were statistically significant). Logistic regression analysis showed that the possibility of a boy being delivered by a mother who smoked was significantly greater in primiparous women than in women who had parity >or=3, independent of the maternal age. Conversely, parity did not affect significantly the sex ratio in the offspring of nonsmoking women.


CONCLUSIONS
The findings suggest that among women who smoked, significantly more male than female offspring are born from primiparous women, whereas women who had parity >or=3 gave birth to more female offspring; biparous women give birth to significantly more male offspring, but the offspring sex ratio declined with the number of cigarettes when the mothers smoked >or=10 cigarettes per day.
Beratis
Nicholas G
NG
Department of Pediatrics, General University Hospital of Patras, University of Patras Medical School, Rio, Patras, Greece. nic-bera@med.upatras.gr
Asimacopoulou
Aspasia
A
Varvarigou
Anastasia
A
D000328:Adult; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D016015:Logistic Models; D008297:Male; D008423:Maternal Age; D016017:Odds Ratio; D010298:Parity; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011446:Prospective Studies; D012744:Sex Ratio; D012907:Smoking; D013997:Time Factors