Synthesis, characterization, cytotoxicity, antibacterial and antifungal evaluation of some new platinum (IV) and palladium (II) complexes of thiodiamines.
Some new platinum (IV) and palladium (II) thiodiamine complexes of type [Pt(L)2Cl2] and [Pd(L)Cl2], [where, L=(cyclohexyl-N-thio)-1,2-ethylenediamine (L(1)) and (cyclohexyl-N-thio)-1,3-propanediamine (L(2))] have been synthesized. The thiodiamines coordinate as a bidentate N-S ligand. The synthesized platinum (IV) and palladium (II) complexes of the thiodiamines were characterized by elemental analysis, IR, mass, electronic and (1)H NMR spectroscopic studies. These complexes were also screened for cytotoxicity, in vitro antifungal and in vitro antibacterial activities. Thermodynamic parameters such as activation energy (Ea), apparent activation entropy (S(#)) and enthalpy change (DeltaH) for the dehydration and decomposition reactions of one complex has also been evaluated.
Mishra
A K
AK
Department of Chemistry, University of Delhi, Delhi 110007, India. ajaykmishra1@yahoo.com
Kaushik
N K
NK
D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity*; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D001230:Aspergillus / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D017671:Platinum Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D013057:Spectrum Analysis; D013438:Sulfhydryl Compounds / Q000737:chemistry*; D013696:Temperature
D000588:Amines; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D017671:Platinum Compounds; D013438:Sulfhydryl Compounds; D010165:Palladium