E-cadherin, beta-catenin, invasion and lymph node metastases in canine malignant mammary tumours.
Recent studies of canine malignant mammary tumours suggest that reduction of E-cadherin and/or beta-catenin correlates with invasive behaviour and lymph node metastasis. The aims of this study were to examine the interrelationships between the expression of E-cadherin and beta-catenin, and the relationship between the expression of E-cadherin and/or beta-catenin and the mode of growth and metastatic capacity of canine malignant mammary tumours. 90 spontaneous malignant tumours and local and regional lymph nodes were studied. A significant relationship was evidenced between membranous expression of E-cadherin and beta-catenin (p=0.0027), but not between E-cadherin and cytoplasmic beta-catenin. Only E-cadherin as a separate factor was significantly related to tumour invasion (p=0.0072) and lymph node metastasis (p=0.0001). Neither membranous nor cytoplasmic beta-catenin expression was significantly related to either of these phenomena.
De Matos
Augusto José Ferreira
AJ
Instituto de Ciências Biomédicas de Abel Salazar, University of Porto, Porto, Portugal.
Lopes
Célia Cristina Carreiras
CC
Faustino
Augusto Manuel Rodrigues
AM
Carvalheira
Júlio Gil Vale
JG
Rutteman
Gerard Roel
GR
Gärtner
Maria De Fátima Rodrigues Moutinho
Mde F
D000818:Animals; D015820:Cadherins / Q000032:analysis* / Q000378:metabolism; D004285:Dogs; D015536:Down-Regulation; D005260:Female; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis; D015674:Mammary Neoplasms, Animal / Q000737:chemistry / Q000473:pathology*; D009361:Neoplasm Invasiveness; D051176:beta Catenin / Q000032:analysis* / Q000378:metabolism
D015820:Cadherins; D051176:beta Catenin