Neurologic manifestations of the antiphospholipid syndrome.
Antiphospholipid syndrome is an important cause of neurologic morbidity. The clinical criteria for antiphospholipid syndrome include only cerebrovascular arterial and venous thrombosis, but many other neurologic manifestations have been associated with antiphospholipid antibodies (aPL). This review discusses the role of aPL in cerebrovascular manifestations and in some of the other neurologic manifestations commonly associated with these antibodies, as well as data pertaining to the pathophysiology of aPL-associated neurologic manifestations and treatment issues.
Roldan
Jose F
JF
School of Medicine, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA.
Brey
Robin L
RL
D045163:Antibodies, Phospho-Specific / Q000097:blood*; D016736:Antiphospholipid Syndrome / Q000150:complications* / Q000175:diagnosis / Q000276:immunology; D002493:Central Nervous System Diseases / Q000175:diagnosis / Q000209:etiology* / Q000276:immunology; D006801:Humans; D020246:Venous Thrombosis / Q000209:etiology / Q000276:immunology / Q000503:physiopathology
D045163:Antibodies, Phospho-Specific