Nitrofurantoin-induced lung- and hepatotoxicity.
We present the case of a patient referred to the gastroenterology service for investigation of abnormal liver function tests. She had been taking nitrofurantoin for 16 months as prophylaxis against urinary tract infections. CT scan showed evidence of lung pneumonitis and low attenuation in the liver parenchyma. Nitrofurantoin-induced pneumonitis and hepatotoxicity was diagnosed. The patient responded both clinically and biochemically to withdrawal of nitrofurantoin. This combination of adverse reaction to nitrofurantoin is rare.
Koulaouzidis
Anastasios
A
Department of Gastroenterology, Warrington Hospital, Warrington. akoulaouzidis@hotmail.com
Bhat
Shivaram
S
Moschos
John
J
Tan
Chew
C
De Ramon
Ana
A
D000892:Anti-Infective Agents, Urinary / Q000008:administration & dosage / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000000981:diagnostic imaging* / Q000209:etiology; D005260:Female; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging; D008168:Lung / Q000000981:diagnostic imaging; D008875:Middle Aged; D009582:Nitrofurantoin / Q000008:administration & dosage / Q000009:adverse effects*; D011014:Pneumonia / Q000139:chemically induced / Q000000981:diagnostic imaging*; D013902:Radiography, Thoracic; D014057:Tomography, X-Ray Computed; D014552:Urinary Tract Infections / Q000517:prevention & control
D000892:Anti-Infective Agents, Urinary; D009582:Nitrofurantoin