Cell stress induced HSP are targets of regulatory T cells: a role for HSP inducing compounds as anti-inflammatory immuno-modulators?
T cell responses to heat shock proteins (HSP) have disease suppressive activities through production of anti-inflammatory cytokines in patients and in models of inflammatory diseases. There is evidence that the anti-inflammatory activity of HSP-specific T cells depends on their recognition of endogenous HSP epitopes as expressed by stressed cells at sites of inflammation. Previously, we have demonstrated that such T cells can be induced by conserved sequences of microbial HSP. Now we propose that drug induced up-regulation of endogenous HSP can contribute to anti-inflammatory T cell regulation.
Wieten
Lotte
L
Division of Immunology, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, University of Utrecht, Yalelaan 1, 3584CL Utrecht, The Netherlands.
Broere
Femke
F
van der Zee
Ruurd
R
Koerkamp
Elles Klein
EK
Wagenaar
Josée
J
van Eden
Willem
W
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D006360:Heat-Shock Proteins / Q000378:metabolism*; D006801:Humans; D007154:Immune System Diseases / Q000276:immunology; D007249:Inflammation / Q000276:immunology*; D009092:Mucous Membrane / Q000276:immunology; D016328:NF-kappa B / Q000037:antagonists & inhibitors; D051381:Rats; D050378:T-Lymphocytes, Regulatory / Q000378:metabolism*; D015854:Up-Regulation
D000893:Anti-Inflammatory Agents; D006360:Heat-Shock Proteins; D016328:NF-kappa B