Experimental tissue regeneration by DDS technology of bio-signaling molecules.
The medical therapy of tissue regeneration achieved by biomaterial-based tissue engineering has been currently expected as the third option following reconstructive surgery and organ transplantation. The basic idea of this regenerative therapy is to assist the self-healing potentials of body to induce the natural regeneration and repairing of defective or injured tissue. To this end, it is practically important to create a local environment which enables cells to promote their proliferation and differentiation, resulting in the induction of cell-based tissue regeneration. Tissue engineering is a biomedical technology or methodology to build up this regeneration environment by making use of biomaterials. Drug delivery system (DDS) is a biomaterial technology to enhance the in vivo biological functions of bio-signaling molecules (growth factors and genes) for promoted tissue regeneration. This paper overviews the recent status of tissue regeneration therapy based on the DDS technology of bio-signaling molecules.
Kimura
Yu
Y
Department of Biomaterials, Field of Tissue Engineering, Institute for Frontier Medical Sciences, Kyoto University, 53 Kawara-cho Shogoin, Sakyo-ku, Kyoto 606-8507, Japan.
Tabata
Yasuhiko
Y
D000818:Animals; D001672:Biocompatible Materials; D001709:Biotechnology; D002454:Cell Differentiation; D049109:Cell Proliferation; D016503:Drug Delivery Systems; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000008:administration & dosage; D051379:Mice; D051381:Rats; D012038:Regeneration; D044968:Regenerative Medicine / Q000295:instrumentation*; D017768:Skin, Artificial; D023822:Tissue Engineering / Q000295:instrumentation* / Q000379:methods*; D014945:Wound Healing
D001672:Biocompatible Materials; D036341:Intercellular Signaling Peptides and Proteins