[Metabolic disorders in patients with chronic obstructive pulmonary disease].
OBJECTIVE
To characterize cell dysregulation in chronic obstructive pulmonary disease (COPD) at local and systemic levels.


METHODS
A total of 48 patients with COPD were examined (mean disease duration 11.2 +/- 7.2 years, mean age 58 +/- 4.2 years). Content of glutathione, and activity of glutathione peroxidase, glutathione reductase in whole blood (Novgorodtseva T.P., 2003), catalase in erythrocytes (Karpichenko A.I., 1999) were determined. Products of lipid peroxidation in exhaled breath condensate were defined to reveal diene conjugates of hydroperoxides, ketodienes, coupled trienes (Khyshiktuyev B.S., 1996).


RESULTS
An evident oxidation stress at the local level was revealed in patients with COPD in deficiency of enzymatic antiperoxide link of anti-oxidant defense that is characterized by increased quantity of lipid peroxidation intermediants both in heptane and isopropanol phases.
Kalinina
E P
EP
Ivanov
E M
EM
Ian'kova
V I
VI
Vitkina
T I
TI
D000975:Antioxidants / Q000378:metabolism*; D001944:Breath Tests; D002374:Catalase / Q000097:blood; D004912:Erythrocytes / Q000201:enzymology / Q000378:metabolism; D005978:Glutathione / Q000097:blood; D005979:Glutathione Peroxidase / Q000097:blood; D005980:Glutathione Reductase / Q000097:blood; D006801:Humans; D008054:Lipid Peroxides / Q000032:analysis / Q000378:metabolism*; D008875:Middle Aged; D029424:Pulmonary Disease, Chronic Obstructive / Q000097:blood / Q000175:diagnosis / Q000378:metabolism*; D012720:Severity of Illness Index
D000975:Antioxidants; D008054:Lipid Peroxides; D002374:Catalase; D005979:Glutathione Peroxidase; D005980:Glutathione Reductase; D005978:Glutathione