title: Effect of recombinant human bone morphogenetic protein-2 on mandibular distraction at different rates in a rabbit model.
abstract: This study aims to evaluate the effect of recombinant human bone morphogenetic protein-2 (rhBMP-2) on mandibular distraction at routine and rapid distraction rates. Eighteen New Zealand white rabbits were assigned to 2 groups, 1 treated at a routine distraction rate (0.9 mm/d) and the other at a rapid distraction rate (2.7 mm/d). rhBMP-2 was injected into 1 side of the distraction regenerate at the end of the active distraction period; the contralateral side was used as a control. The distraction regenerates were analyzed by plain radiography, microcomputed tomography, and histologic examination. The results showed that rhBMP-2 can promote bone formation at both rapid and routine distraction rates, but no statistically significant difference was observed between the bone morphogenetic protein injection sides of the rapid and routine distraction groups. In conclusion, the study indicates that rhBMP-2 can enhance bone ossification at both routine and rapid distraction rates. The addition of rhBMP-2 seems to be able to compensate for the rapid distraction rate in mandibular distraction osteogenesis. Further longterm follow-up and mechanical strength test for the support of implants or conventional prostheses are necessary.
authors.affiliation: Discipline of Oral & Maxillofacial Surgery, Faculty of Dentistry, University of Hong Kong, Hong Kong, China.
authors.forename: Li Wu
authors.initials: LW
authors.lastname: Zheng
authors.forename: Lim Kwong
authors.initials: LK
authors.lastname: Cheung
mesh_terms: D000818:Animals; D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins / Q000235:genetics / Q000494:pharmacology* / Q000627:therapeutic use; D001861:Bone Regeneration / Q000187:drug effects* / Q000502:physiology; D016723:Bone Remodeling / Q000187:drug effects / Q000502:physiology; D006651:Histocytochemistry; D006801:Humans; D007700:Kinetics; D008334:Mandible / Q000000981:diagnostic imaging / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology / Q000601:surgery*; D023421:Models, Animal; D010012:Osteogenesis / Q000187:drug effects / Q000502:physiology; D019857:Osteogenesis, Distraction / Q000379:methods*; D011817:Rabbits; D011897:Random Allocation; D011994:Recombinant Proteins / Q000494:pharmacology; D014057:Tomography, X-Ray Computed; D016212:Transforming Growth Factor beta / Q000235:genetics / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: C525718:BMP2 protein, human; D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins; D011994:Recombinant Proteins; D016212:Transforming Growth Factor beta; C499469:recombinant human bone morphogenetic protein-2