Role of beta-chemokines in mast cell activation and type I hypersensitivity reactions in the conjunctiva: in vivo and in vitro studies.
Chemokines have a clearly defined role in mobilizing the recruitment of leukocytes to both healthy and inflamed tissues. This review details work from our and other laboratories, indicating that beta-chemokines may play important roles (i) in driving the terminal differentiation of mast cell precursors in mucosal tissues and (ii) in providing priming or costimulatory signals required for mast cell activation, leading to an antigen-driven inflammatory response. These data stem from in vivo, ex vivo, and in vitro studies. Data are also presented that suggest that Fc epsilon RI:chemokine receptor cross talk may involve spatiotemporal dynamics that may control the strength and nature of the complex activating signals controlling mast cell effector function.
Beer
Frederick
F
Emory University School of Medicine, Emory Eye Center, Atlanta, GA, USA.
Kuo
Chuan-Hui
CH
Morohoshi
Kei
K
Goodliffe
James
J
Munro
Peter
P
Aye
Cho Cho
CC
Dawson
Maria
M
Richardson
Ricardo M
RM
Jones
Limei H
LH
Ikeda
Yoshifumi
Y
Nakamura
Takao
T
Toda
Masako
M
Flynn
Tom
T
Ohbayashi
Masaharu
M
Miyazaki
Dai
D
Ono
Santa Jeremy
SJ
D000818:Animals; D002462:Cell Membrane / Q000737:chemistry; D019742:Chemokines, CC / Q000032:analysis / Q000235:genetics / Q000378:metabolism*; D003228:Conjunctiva / Q000276:immunology*; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology*; D008407:Mast Cells / Q000276:immunology* / Q000648:ultrastructure; D017455:Receptors, IgE / Q000276:immunology*
D019742:Chemokines, CC; D017455:Receptors, IgE