Common contact allergens associated with eyelid dermatitis: data from the North American Contact Dermatitis Group 2003-2004 study period.
BACKGROUND
Allergic contact dermatitis can be manifest as an eruption confined to the eyelids. In regard to this specific presentation, only limited information on which to base the selection of patch tests for proper evaluation is available.


OBJECTIVE
To identify the contact allergens most frequently found to be both patch test positive and relevant when only the eyelids are involved.


METHODS
Data collected from 2003 to 2004 by the North American Contact Dermatitis Group (NACDG) were analyzed for relevant allergens in the setting of dermatitis on the eyelids only. Data on eyelid dermatitis patients whose relevant allergens were not among the 65 allergens used for screening during this study period were also tabulated.


RESULTS
Data showed that 268 patients had only eyelid dermatitis and a final diagnosis of allergic contact dermatitis. In 193 (72%) of these, reactions were of current relevance and were identified from a screening series of 65 allergens. The top 26 allergens identified 65% of cases (175 cases). Gold was the most frequently encountered allergen (22 of 175 cases [12.5%]). Of the 268 cases, 33 showed relevant reactions to an allergen that was not among the 65 NACDG standard screening allergens. No specific allergen was identified in the remaining 42 cases.


CONCLUSIONS
The top 26 allergens identified in this study represent a potential eyelid dermatitis screening series.
Rietschel
Robert L
RL
Southern Arizona VA Health Care System, Tucson, AZ, USA.
Warshaw
Erin M
EM
Sasseville
Denis
D
Fowler
Joseph F
JF
DeLeo
Vincent A
VA
Belsito
Donald V
DV
Taylor
James S
JS
Storrs
Frances J
FJ
Mathias
C G Toby
CG
Maibach
Howard I
HI
Marks
James G
JG
Zug
Kathryn A
KA
Pratt
Melanie
M
D000485:Allergens / Q000009:adverse effects*; D003358:Cosmetics / Q000009:adverse effects*; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology; D005141:Eyelid Diseases / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology; D006046:Gold / Q000009:adverse effects*; D006801:Humans; D009656:North America / Q000453:epidemiology; D010328:Patch Tests / Q000379:methods
D000485:Allergens; D003358:Cosmetics; D006046:Gold