[DNA ploidy and proliferative activity in salivary gland tumours].
DNA ploidy and S-Phase fraction (SPF) of 279 salivary gland tumours were analysed using high-resolution DNA flow cytometry. All 229 benign neoplasms were diploid while 12 of 50 malignant tumours showed cell populations with aneuploid DNA content. The SPF values of diploid malignancies were significantly higher if compared with pleomorphic adenomas but did not differ from that of the zystadenolymphoma (Warthin tumour) group. While aneuploidy represents a distinct indicator of malignancy SPF values are of minor relevance for dignity assessment in salivary gland tumours.
Driemel
Oliver
O
Universität Regensburg, Klinik und Poliklinik für Mund-, Kiefer- und Gesichtschirurgie, Franz-Josef-Strauss-Allee 11, 93053 Regensburg, Germany.
Kraft
Klaus
K
Hemmer
Jörg
J
D000235:Adenolymphoma / Q000235:genetics / Q000473:pathology; D008949:Adenoma, Pleomorphic / Q000235:genetics / Q000473:pathology; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002455:Cell Division / Q000235:genetics*; D002648:Child; D004273:DNA, Neoplasm / Q000235:genetics*; D003937:Diagnosis, Differential; D004171:Diploidy; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D008297:Male; D008875:Middle Aged; D011003:Ploidies; D012466:Salivary Gland Diseases / Q000235:genetics / Q000473:pathology; D012468:Salivary Gland Neoplasms / Q000235:genetics* / Q000473:pathology; D012469:Salivary Glands / Q000473:pathology; D012680:Sensitivity and Specificity
D004273:DNA, Neoplasm