title: Discovery of para-alkylthiophenoxyacetic acids as a novel series of potent and selective PPARdelta agonists.
abstract: A novel series of potent and selective PPARdelta agonists, para-alkylthiophenoxyacetic acids, was identified. The synthesis and structure-activity relationships are described.
authors.affiliation: Drug Discovery, Johnson and Johnson Pharmaceutical Research and Development, LLC, 8 Clarke Drive, Cranbury, NJ 08512, USA. rzhang4@prdus.jnj.com
authors.forename: Rui
authors.initials: R
authors.lastname: Zhang
authors.forename: Aihua
authors.initials: A
authors.lastname: Wang
authors.forename: Alan
authors.initials: A
authors.lastname: DeAngelis
authors.forename: Patricia
authors.initials: P
authors.lastname: Pelton
authors.forename: Jun
authors.initials: J
authors.lastname: Xu
authors.forename: Peifang
authors.initials: P
authors.lastname: Zhu
authors.forename: Lubing
authors.initials: L
authors.lastname: Zhou
authors.forename: Keith
authors.initials: K
authors.lastname: Demarest
authors.forename: William V
authors.initials: WV
authors.lastname: Murray
authors.forename: Gee-Hong
authors.initials: GH
authors.lastname: Kuo
mesh_terms: D019540:Area Under Curve; D006016:Glycolates / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology*; D047494:PPAR delta / Q000819:agonists*; D013329:Structure-Activity Relationship
chemical_list: D006016:Glycolates; D047494:PPAR delta; C005446:thiophenoxyacetic acid