title: Time courses of brain activation and their implications for function: a multichannel near-infrared spectroscopy study during finger tapping.
abstract: The time courses of brain activation were monitored during a finger tapping task using multichannel near-infrared spectroscopy with a time resolution of 0.1s in 30 healthy volunteers. Task-induced brain activations were demonstrated as significant increases in oxygenated hemoglobin concentration ([oxy-Hb]) in a broad area around the motor cortex and significant decreases in deoxygenated hemoglobin concentration ([deoxy-Hb]) in a more restricted area, with a large degree of activation in the contralateral hemisphere. The time courses of the [oxy-Hb] changes varied depending on channel location: sustained activation across the task period in the motor cortex, transient activation during the initial segments of the task period in the somatosensory cortex, and accumulating activation along the task period in the frontal lobe. These characteristics are assumed to reflect the functional roles of the brain structures during the task period, that is, the execution, sensory monitoring, and maintenance of finger tapping.
authors.affiliation: Department of Psychiatry and Human Behavior, Gunma University Graduate School of Medicine, 3-39-22 Showa, Maebashi, Gunma 371-8511, Japan.
authors.forename: Toshimasa
authors.initials: T
authors.lastname: Sato
authors.forename: Makoto
authors.initials: M
authors.lastname: Ito
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Suto
authors.forename: Masaki
authors.initials: M
authors.lastname: Kameyama
authors.forename: Masashi
authors.initials: M
authors.lastname: Suda
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Yamagishi
authors.forename: Akihiko
authors.initials: A
authors.lastname: Ohshima
authors.forename: Toru
authors.initials: T
authors.lastname: Uehara
authors.forename: Masato
authors.initials: M
authors.lastname: Fukuda
authors.forename: Masahiko
authors.initials: M
authors.lastname: Mikuni
mesh_terms: D000328:Adult; D001931:Brain Mapping; D002560:Cerebrovascular Circulation; D005260:Female; D005385:Fingers / Q000294:innervation / Q000502:physiology*; D007839:Functional Laterality; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D008297:Male; D009044:Motor Cortex / Q000378:metabolism*; D011597:Psychomotor Performance / Q000502:physiology*; D011930:Reaction Time / Q000502:physiology*; D019265:Spectroscopy, Near-Infrared; D013997:Time Factors
chemical_list: D006454:Hemoglobins