title: The early phase of the minute ventilation recovery curve predicts extubation failure better than the minute ventilation recovery time.
abstract: OBJECTIVE
  To determine, in patients who had successful outcomes in spontaneous breathing trials (SBTs), whether the analysis of the minute ventilation (Ve) recovery time obtained by minute-by-minute sequential monitoring after placing the patient back on mechanical ventilation (MV) may be useful in predicting extubation outcome.
  
  
  METHODS
  Twelve-month prospective observational study.
  
  
  METHODS
  Medical-surgical ICU of a university hospital.
  
  
  METHODS
  Ninety-three patients receiving > 48 h of MV.
  
  
  METHODS
  Baseline respiratory parameters (ie, respiratory rate, tidal volume, and Ve) were measured under pressure support ventilation prior to the SBT. After tolerating the SBT, patients again received MV with their pre-SBT ventilator settings, and respiratory parameters were recorded minute by minute.
  
  
  RESULTS
  Seventy-four patients (80%) were successfully extubated, and 19 patients (20%) were reintubated. Reintubated patients were similar to non-reintubated patients in baseline respiratory parameters and baseline variables, except for age and COPD diagnosis. The recovery time needed to reduce Ve to half the difference between the Ve measured at the end of a successful SBT and basal Ve (RT50%DeltaVe) was lower in patients who had undergone successful extubation than in those who had failed extubation (mean [+/- SD] time, 2.7 +/- 1.2 vs 10.8 +/- 8.4 min, respectively; p < 0.001). Multiple logistic regression adjusted for age, sex, comorbid status, diagnosis (ie, neurocritical vs other), and severity of illness revealed that neurocritical disease (odds ratio [OR], 7.6; p < 0.02) and RT50%DeltaVe (OR, 1.7; p < 0.01) were independent predictors of extubation outcome. The area under the receiver operating characteristic curve for the predictive model was 0.89 (95% confidence interval, 0.81 to 0.96).
  
  
  CONCLUSIONS
  Determination of the RT50%DeltaVe at the bedside may be a useful adjunct in the decision to extubate, with better results found in nonneurocritical patients.
authors.affiliation: Intensive Care Unit, Hospital 12 de Octubre, Mezquite No. 12, 6o A, 28045 Madrid, Spain. ghernandezm@telefonica.net
authors.forename: Gonzalo
authors.initials: G
authors.lastname: Hernandez
authors.forename: Rafael
authors.initials: R
authors.lastname: Fernandez
authors.forename: Elena
authors.initials: E
authors.lastname: Luzon
authors.forename: Rafael
authors.initials: R
authors.lastname: Cuena
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Montejo
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007440:Intubation; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011446:Prospective Studies; D020127:Recovery of Function / Q000502:physiology*; D012119:Respiration; D015656:Respiratory Mechanics / Q000502:physiology; D013990:Tidal Volume / Q000502:physiology; D013997:Time Factors; D016896:Treatment Outcome; D015300:Ventilator Weaning / Q000379:methods*