title: [Paclitaxel-induced lupus].
abstract: BACKGROUND
  Paclitaxel (Taxol) is a drug derived from the bark of the Pacific yew tree and is widely used in cancer treatment, especially for breast, ovarian, and lung cancers. It has not previously been reported to induce lupus.
  
  
  METHODS
  We report the case of a woman with ovarian cancer who developed paclitaxel-induced lupus on two occasions. Both times, the paclitaxel dramatically improved the ovarian cancer.
  
  
  CONCLUSIONS
  The diagnosis of lupus was confirmed by the initial skin appearance, elevated levels of antinuclear antibodies, recurrence on reintroduction, and biopsy results. To our knowledge, it is the first case reported of paclitaxel-induced lupus.
authors.affiliation: Service de chimiothérapie, Centre Catherine de Sienne, Nantes. lortholary.alain@catherinedesienne.fr
authors.forename: Alain
authors.initials: A
authors.lastname: Lortholary
authors.forename: Myriam
authors.initials: M
authors.lastname: Cary-Ten Have Dallinga
authors.forename: Claude
authors.initials: C
authors.lastname: El Kouri
authors.forename: Nadine
authors.initials: N
authors.lastname: Morineau
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Ramée
mesh_terms: D000368:Aged; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000627:therapeutic use; D000974:Antibodies, Antinuclear / Q000032:analysis; D000972:Antineoplastic Agents, Phytogenic / Q000009:adverse effects* / Q000627:therapeutic use; D001623:Betamethasone / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000627:therapeutic use; D001706:Biopsy; D004359:Drug Therapy, Combination; D004921:Erythropoietin / Q000008:administration & dosage / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008178:Lupus Erythematosus, Cutaneous / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology / Q000473:pathology; D010051:Ovarian Neoplasms / Q000188:drug therapy; D017239:Paclitaxel / Q000009:adverse effects*; D011994:Recombinant Proteins; D012008:Recurrence; D012867:Skin / Q000473:pathology; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents; D000974:Antibodies, Antinuclear; D000972:Antineoplastic Agents, Phytogenic; D011994:Recombinant Proteins; C103998:epoetin beta; D004921:Erythropoietin; C011175:betamethasone-17,21-dipropionate; D001623:Betamethasone; D017239:Paclitaxel