title: A short C-terminal region of alpha-synuclein protects a (R/S)-non-specific esterase from Archaeglobus fulgidus.
abstract: We show that alpha-synuclein could assist the molecular activity of a ketoprofen-(R/S) nonspecific esterase from Archaeglobus Fulgidus. Specifically, several synthetic peptides from alpha-synuclein, each having random coil conformation in far-UV spectra, could protect the enzyme activity against stress conditions such as heat and organic solvents.
authors.affiliation: Department of Biological and Molecular Engineering, College of Engineering, Ajou University, Suwon, South Korea.
authors.forename: Seungbum
authors.initials: S
authors.lastname: Kim
authors.forename: Mira
authors.initials: M
authors.lastname: Kang
authors.forename: Yeonwoo
authors.initials: Y
authors.lastname: Ryu
authors.forename: T Doohun
authors.initials: TD
authors.lastname: Kim
mesh_terms: D000595:Amino Acid Sequence; D001105:Archaea / Q000187:drug effects / Q000201:enzymology; D043182:Carboxylesterase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D004121:Dimethyl Sulfoxide / Q000494:pharmacology; D004795:Enzyme Stability / Q000187:drug effects; D006358:Hot Temperature; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000378:metabolism*; D012997:Solvents; D051844:alpha-Synuclein / Q000378:metabolism*
chemical_list: D010446:Peptide Fragments; D012997:Solvents; D051844:alpha-Synuclein; D043182:Carboxylesterase; D004121:Dimethyl Sulfoxide