title: Role of tight junctions in cell proliferation and cancer.
abstract: The acquisition of a cancerous phenotype by epithelial cells involves the disruption of intercellular adhesions. The reorganization of the E-cadherin/beta-catenin complex in adherens junctions during cell transformation is widely recognized. Instead the implication of tight junctions (TJs) in this process is starting to be unraveled. The aim of this article is to review the role of TJ proteins in cell proliferation and cancer.
authors.affiliation: Center for Research and Advanced Studies (Cinvestav), Department of Physiology, Biophysics and Neuroscience, Ave. Instituto Politécnico Nacional 2508, México, DF 07360, México. lorenza@fisio.cinvestav.mx
authors.forename: Lorenza
authors.initials: L
authors.lastname: González-Mariscal
authors.forename: Susana
authors.initials: S
authors.lastname: Lechuga
authors.forename: Erika
authors.initials: E
authors.lastname: Garay
mesh_terms: D049109:Cell Proliferation; D008954:Models, Biological; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D019108:Tight Junctions / Q000378:metabolism* / Q000502:physiology*