[Comparison of properties of Mahuang decoction and Maxing Shigan decoction based on biothermodynamics].
OBJECTIVE
To probe into the objectivity and authenticity of four properties beteen Mahuang decoction and Maxing Shigan decoction from biothermodynamics.


METHODS
The power-time curves of growth of Staphylococcus aureus at different concentrations between Mahuang decoction and Maxing Shigan decoction were determined by TAM Air Isothermal Calorimeter. The growth rate constants of promotive and inhibitory actions were calculated. Moreover, the difference of properties beteen Mahuang decoction and Maxing Shigan decoction was analyzed from the point of view of TCM theory.


RESULTS
Both the Mahuang decoction and Maxing Shigan decoction could inhibit the growth and metabolism of Staphylococcus aureus. The k and Pm were decreased with the mass increase of the decoction. However, inhibitory activity of Mahuang decoction with warm property was weaker than that of Maxing Shigan decoction with cool property. Moreover, Mahuang decoction decreased heat output in growth metabolism more weakly than Maxing Shigan decoction. There was a stable difference between them.


CONCLUSIONS
Studying on biothermodynamics can show the difference of four properties of Traditional Chinese Medicine. So, it provides a new and useful means for the study of the properties of traditional Chinese medicine.
Fan
Dong-Li
DL
Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100094, China. pharmacy302@sohu.com
Liao
Qing-Wen
QW
Yan
Dan
D
Ma
Xiao-Jun
XJ
Xiao
Xiao-He
XH
Zhao
Yan-Ling
YL
D002133:Calcium Sulfate / Q000737:chemistry; D002151:Calorimetry; D027424:Cinnamomum / Q000737:chemistry; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D029790:Ephedra sinica / Q000737:chemistry; D029882:Glycyrrhiza uralensis / Q000737:chemistry; D008419:Materia Medica / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D008516:Medicine, Chinese Traditional; D010946:Plants, Medicinal / Q000737:chemistry*; D027861:Prunus / Q000737:chemistry; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D013816:Thermodynamics
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; C493483:Mao-to; D008419:Materia Medica; D002133:Calcium Sulfate