title: Antinociceptive effect and acute toxicity of the Hyptis suaveolens leaves aqueous extract on mice.
abstract: The aqueous extract of Hyptis suaveolens leaves was studied for their antinociceptive property in chemical and thermal models of nociception in mice. Oral administration of the aqueous extract (100, 200, and 400 mg/kg) dose-dependently reduced the number of writhings induced by acetic acid, decreased the licking activity of the early phase in formalin test and increased the reaction time in hot-plate test. The antinociceptive effect was significantly antagonized by naloxone (3 mg/kg; i.p.). Preliminary acute toxicity study showed that no animal death with doses up to 5 g/kg (p.o.).
authors.affiliation: Department of Physiology, Faculty of Pharmaceutical Sciences, Federal University of Sergipe, São Cristovão, Brazil. thc_santos80@hotmail.com
authors.forename: Thiago C
authors.initials: TC
authors.lastname: Santos
authors.forename: Maxsuel S
authors.initials: MS
authors.lastname: Marques
authors.forename: Igor A C
authors.initials: IA
authors.lastname: Menezes
authors.forename: Kellyane S
authors.initials: KS
authors.lastname: Dias
authors.forename: Aline B L
authors.initials: AB
authors.lastname: Silva
authors.forename: Iderjane C M
authors.initials: IC
authors.lastname: Mello
authors.forename: Ana C S
authors.initials: AC
authors.lastname: Carvalho
authors.forename: Sócrates C H
authors.initials: SC
authors.lastname: Cavalcanti
authors.forename: Angelo R
authors.initials: AR
authors.lastname: Antoniolli
authors.forename: Rosilene M
authors.initials: RM
authors.lastname: Marçal
mesh_terms: D019342:Acetic Acid; D000284:Administration, Oral; D000700:Analgesics / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D006358:Hot Temperature; D031331:Hyptis; D008297:Male; D051379:Mice; D010146:Pain / Q000139:chemically induced / Q000517:prevention & control*; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves
chemical_list: D000700:Analgesics; D010936:Plant Extracts; D019342:Acetic Acid