Synthesis of kaempferitrin.
A short synthesis of Kaempferitrin (1), a 3,7-diglycosylflavone, is reported. Key features include the synthesis of a protected form of kaempferol in which all four hydroxy groups are differentiated and the first bis-glycosylation of a dihydroxyflavone. This synthesis will allow the preparation of derivatives for further explorations into the origins of this compound's biological activity.
Urgaonkar
Sameer
S
Chemical Biology Program, Broad Institute of Harvard and MIT, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA.
Shaw
Jared T
JT
D006031:Glycosylation; D044949:Kaempferols / Q000138:chemical synthesis* / Q000737:chemistry; D010696:Phloroglucinol / Q000737:chemistry
D044949:Kaempferols; D010696:Phloroglucinol; C042728:lespenefril