title: Failure of Duddingtonia flagrans to reduce gastrointestinal nematode infections in dairy ewes.
abstract: A field study was conducted on three Swiss farms to investigate the efficacy of Duddingtonia flagrans against naturally acquired infections of gastrointestinal nematodes in adult dairy sheep. On each farm the ewes were divided into two equal groups. One group received Duddingtonia during a period of 4 months at a daily dose rate of 10(6) chlamydospores per kilogram body weight, the second group acted as controls. At an overall moderate infection level in all farms D. flagrans did not have a significant effect on the observed parasitological parameters with the exception of a significantly reduced herbage infectivity in one farm. In contrast, the results from faecal cultures indicated a mean suppression of larval development during the fungus-feeding period between 82, 89 and 93% on the three farms, respectively. The discrepancy observed between the fungus efficacy in coprocultures and on pasture, which was also observed in several other studies deserves further research.
authors.affiliation: Institute of Parasitology, University of Zurich, Winterthurerstrasse 266a, CH-8057 Zurich, Switzerland.
authors.forename: H
authors.initials: H
authors.lastname: Faessler
authors.forename: P R
authors.initials: PR
authors.lastname: Torgerson
authors.forename: H
authors.initials: H
authors.lastname: Hertzberg
mesh_terms: D000818:Animals; D001203:Ascomycota / Q000187:drug effects / Q000502:physiology*; D003612:Dairying; D005243:Feces / Q000469:parasitology; D005260:Female; D007814:Larva; D010270:Parasite Egg Count / Q000662:veterinary; D019936:Probiotics / Q000008:administration & dosage / Q000494:pharmacology*; D011891:Rain; D012756:Sheep; D012757:Sheep Diseases / Q000469:parasitology* / Q000517:prevention & control*; D017211:Treatment Failure; D014251:Trichostrongyloidea / Q000187:drug effects / Q000302:isolation & purification; D014252:Trichostrongyloidiasis / Q000382:microbiology / Q000517:prevention & control / Q000662:veterinary*