title: Structural and biological studies of mononuclear palladium(II) complexes containing N-substituted thiosemicarbazones.
abstract: New complexes of Pd(II) with N-substituted thiosemicarbazone (1)-(3) have been synthesised and characterised by elemental analyses, IR, electronic, (1)H NMR spectroscopies. The electrochemical behaviour of the complexes has been tested by using cyclic voltammetry. The crystal structures of the complexes have been determined by single crystal X-ray diffraction technique. In all the complexes the thiosemicarbazone ligand is coordinated to palladium through ONS mode. The complex 1 crystallises in the monoclinic space group P2(1)/c with two molecules per unit cell, has the dimensions of a=9.4390(19)A, b=10.645(2)A, c=13.668(3)A, alpha=90 degrees , beta=91.43 degrees and gamma=90 degrees . The complex 3 crystallises in the monoclinic space group P2(1)/c with four molecules per unit cell, has the dimensions of a=14.119(3)A, b=11.155(2)A, c=18.503(4)A, alpha=90 degrees , beta=112.02 degrees and gamma=90 degrees . The new complexes have been tested for their antibacterial activity against various pathogenic bacteria. From this study, it was found out that the activity of the complex 2 almost reaches the effectiveness of the conventional bacteriocide Streptomycin.
authors.affiliation: Department of Chemistry, Bharathiar University, Coimbatore 641 046, Tamilnadu, India.
authors.forename: R
authors.initials: R
authors.lastname: Prabhakaran
authors.forename: S V
authors.initials: SV
authors.lastname: Renukadevi
authors.forename: R
authors.initials: R
authors.lastname: Karvembu
authors.forename: R
authors.initials: R
authors.lastname: Huang
authors.forename: J
authors.initials: J
authors.lastname: Mautz
authors.forename: G
authors.initials: G
authors.lastname: Huttner
authors.forename: R
authors.initials: R
authors.lastname: Subashkumar
authors.forename: K
authors.initials: K
authors.lastname: Natarajan
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004563:Electrochemistry; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry* / Q000494:pharmacology*; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D013882:Thiosemicarbazones / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D013882:Thiosemicarbazones; D010165:Palladium