High temporal resolution breathheld 3D FIESTA CINE imaging: validation of ventricular function in patients with chronic myocardial infarction.
OBJECTIVE
To develop a gated single-breathhold, high temporal resolution three-dimensional (3D) CINE imaging technique and to evaluate its accuracy in volumetric and functional quantification in patients with chronic myocardial infarction.


METHODS
A 3D CINE steady-state free precession (SSFP) pulse sequence was developed incorporating variable temporal sampling of the low and high spatial frequency k-space data to reduce breathhold time and parallel imaging to increase temporal resolution. Reconstruction with retrospective interpolation enabled complete R-R interval coverage. Feasibility was assessed in eight patients with chronic myocardial infarction and ventricular functional values were compared to those of a 2D CINE acquisition.


RESULTS
There was no significant difference between the 3D CINE and 2D CINE for end-diastolic volume (168 +/- 73 vs. 177 +/- 59 mL, respectively; P < 0.27), end-systolic volume (81 +/- 62 vs. 79 +/- 53 mL; P < 0.81), and ejection fraction (EF) measurements (55 +/- 14% vs. 58 +/- 14%; P < 0.14). The mean difference in EF was less than 2.5%. A wall motion assessment indicated a good agreement, with a weighted kappa value of 0.62.


CONCLUSIONS
High temporal resolution 3D CINE SSFP imaging of the whole heart can be obtained in a single breathhold and yield ventricular function measurements similar to 2D CINE methods.
Rettmann
Dan W
DW
Applied Science Laboratory, GE Healthcare, 200 First Street SW, Rochester, MN 55905, USA. dan.rettmann@med.ge.com
Saranathan
Manojkumar
M
Wu
Katherine C
KC
Azevedo
Clerio F
CF
Bluemke
David A
DA
Foo
Thomas K F
TK
D000328:Adult; D002908:Chronic Disease; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D019028:Magnetic Resonance Imaging, Cine / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000503:physiopathology*; D018487:Ventricular Dysfunction, Left / Q000503:physiopathology*