[1,3]Diazaheterofused isoindolol derivatives displaying anxiolytic-like effects on mice.
Anxiolytic-like effects induced on mice by several compounds with imidazo[2,1-a]isoindolol (II), pyrimido[2,1-a]isoindolol (III) and [1,3]diazepino[2,1-a]isoindolol (IV) structures have been evaluated through the elevated plus-maze test. The evaluation has been based on measuring the spent time and counting the number of entries of mice in the open arms of the maze. Single intraperitoneal administration of imidazoisoindolol IIe and pyrimidoisoindolols IIIa, IIIe and IIIg induced significant increments in these behavioural parameters.
Zamilpa
Alejandro
A
Departamento de Química Farmacéutica, Facultad de Farmacia, Campus Unamuno, 37007-Salamanca, Spain.
Herrera-Ruiz
Maribel
M
Del Olmo
Esther
E
López-Pérez
José L
JL
Tortoriello
Jaime
J
San Feliciano
Arturo
A
D000818:Animals; D014151:Anti-Anxiety Agents / Q000737:chemistry / Q000494:pharmacology*; D007211:Indoles / Q000737:chemistry / Q000494:pharmacology*; D018782:Maze Learning; D051379:Mice; D008958:Models, Molecular; D013329:Structure-Activity Relationship
D014151:Anti-Anxiety Agents; D007211:Indoles