Insertion sequence 1515 in the ply gene of a type 1 clinical isolate of Streptococcus pneumoniae abolishes pneumolysin expression.
A serotype 1 Streptococcus pneumoniae strain isolated by blood culture from a woman with pneumonia was found to harbor insertion sequence (IS) 1515 in the pneumolysin gene, abolishing pneumolysin expression. To our knowledge, this is the first report of an IS in the pneumolysin gene of S. pneumoniae.
Garnier
Fabien
F
Laboratoire de Bactériologie-Virologie-Hygiène, EA 3175, CHU DUPUYTREN, 2 avenue Martin Luther King, 87042 Limoges cedex, France. fabien.garnier@unilim.fr
Janapatla
Rajendra Prasad
RP
Charpentier
Emmanuelle
E
Masson
Geoffrey
G
Grélaud
Carole
C
Stach
Jean François
JF
Denis
François
F
Ploy
Marie-Cécile
MC
D001426:Bacterial Proteins / Q000235:genetics; D004251:DNA Transposable Elements / Q000235:genetics*; D005260:Female; D015964:Gene Expression Regulation, Bacterial; D006801:Humans; D008969:Molecular Sequence Data; D016254:Mutagenesis, Insertional; D011018:Pneumonia, Pneumococcal / Q000382:microbiology; D013296:Streptococcus pneumoniae / Q000235:genetics*; D013301:Streptolysins / Q000235:genetics*
D001426:Bacterial Proteins; D004251:DNA Transposable Elements; D013301:Streptolysins; C032290:plY protein, Streptococcus pneumoniae