[Participation of N-cholinergic synapses in the regulation of RNA metabolism of sympathetic neurons and satellite glial cells].
Cytoplasmic rRNA content in neuronal and in satellite glial cells of cervical sympathetic ganglion was defined using photographic cytophotometry during the pharmacological blockade of N-cholinergic (N-CE) synapses, induced by the injection of N-cholinolytic drug dimecoline (10, 30 and 50 mg/kg subcutaneously), as well as during the period of blockade gradual resolution and termination (1-11 hours after treatment with cholinolytic drug). The partial blockade and average intensity blockade induced coordinated oscillations of rRNA content in both types of cells. The coordination of these changes was violated during the complete blockade. Analysis of the results obtained suggested that N-CE synaptic processes directly modulated quantitative changes of rRNA in neuronal cytoplasm could be a factor synchronizing the metabolism of neuronal and glial rRNA in a sympathetic ganglion.
Gorelikov
P L
PL
Savel'ev
S V
SV
D000818:Animals; D018678:Cholinergic Agents / Q000494:pharmacology*; D005728:Ganglia, Sympathetic / Q000187:drug effects / Q000378:metabolism*; D009457:Neuroglia / Q000187:drug effects / Q000378:metabolism*; D009474:Neurons / Q000187:drug effects / Q000378:metabolism*; D010875:Pipecolic Acids / Q000494:pharmacology*; D012313:RNA / Q000378:metabolism*; D011817:Rabbits; D013569:Synapses / Q000187:drug effects / Q000502:physiology*
D018678:Cholinergic Agents; D010875:Pipecolic Acids; C010927:dimecolin; D012313:RNA