title: Trichuris suis excretory/secretory antigen-specific antibodies in serum from single-inoculated pigs.
abstract: The humoral immune response induced by Trichuris infections has mostly been described in mouse models and in infected humans, but as the immunomodulatory effect of Trichuris suis, the swine whipworm, becomes increasingly documented, the need for understanding the response induced by this specific parasite species grows. In the present study we describe changes in serum IgG1, IgG2, IgA and IgM antibodies specific to adult T. suis excretory/secretory (E/S) antigens in the time course of a primary infection in swine. The average levels of specific IgG1, IgG2 and IgM peaked at 9 weeks post-inoculation and then declined within a few weeks of worm expulsion. The IgA level rose earlier and remained elevated after worm expulsion. The protective role of Trichuris-specific antibodies is uncertain, but some of them presumably reflect the presence of worms in the intestine. Further development of this analysis could have diagnostic value in swine and humans infected with T. suis for experimental or therapeutic purposes.
authors.affiliation: Danish Centre for Experimental Parasitology, Department of Veterinary Pathobiology, University of Copenhagen, Frederiksberg, Denmark. helk@life.ku.dk
authors.forename: H
authors.initials: H
authors.lastname: Kringel
authors.forename: A
authors.initials: A
authors.lastname: Roepstorff
mesh_terms: D000818:Animals; D000909:Antibodies, Helminth / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay / Q000662:veterinary; D000939:Epitopes; D005260:Female; D007132:Immunoglobulin Isotypes / Q000097:blood; D008297:Male; D018512:Parasitemia / Q000276:immunology / Q000469:parasitology; D011897:Random Allocation; D013552:Swine; D013553:Swine Diseases / Q000276:immunology* / Q000469:parasitology*; D014257:Trichuriasis / Q000276:immunology / Q000469:parasitology / Q000662:veterinary*; D014258:Trichuris / Q000276:immunology*
chemical_list: D000909:Antibodies, Helminth; D000939:Epitopes; D007132:Immunoglobulin Isotypes