title: Sarcomas and sarcomatoid tumor after radiotherapy of oral squamous cell carcinoma: analysis of 4 cases.
abstract: Radiation-induced sarcoma (RIS) or postirradiation sarcoma has been reported rarely as a long-term complication of radiation therapy (RT). We report 4 cases of oral sarcomas or sarcomatoid tumors with a rather short latency period after radiotherapy of the prior OSCC. Histopathological evaluation and immunohistochemical study were performed using a panel of markers including vimentin, cytokeratin, S-100, desmin, myoglobin, HHF-35, p53, and p16. All reported cases were positive for vimentin and negative for cytokeratin. Two cases were positive for myoglobin, desmin, or HHF-35, and were probably myogenic origin. One case was possibly a fibrosarcoma and the subclassification of the other one was not specified. Diverse expression of p53 and p16 was further observed in these 4 cases. Report of the complicated clinical processes and the analysis of genetic markers of these cases provide useful clinical and pathogenetic insights of mesenchymal malignancies associated with a status post OSCC radiation.
authors.affiliation: Oral and Maxillofacial Surgery, Department of Dentistry, Taipei Veterans General Hospital (Taipei VGH), School of Dentistry, National Yang-Ming University, Taipei, Taiwan, ROC.
authors.forename: Ya-Wei
authors.initials: YW
authors.lastname: Chen
authors.forename: Hsi-Fen
authors.initials: HF
authors.lastname: Tu
authors.forename: Tsen-Hsian
authors.initials: TH
authors.lastname: Wu
authors.forename: Wen-Liang
authors.initials: WL
authors.lastname: Lo
authors.forename: Che-Shoa
authors.initials: CS
authors.lastname: Chang
authors.forename: Kuo-Wei
authors.initials: KW
authors.lastname: Chang
authors.forename: Shou-Yen
authors.initials: SY
authors.lastname: Kao
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000532:radiotherapy*; D017809:Fatal Outcome; D005260:Female; D019942:Genes, p16; D016158:Genes, p53; D005887:Gingival Neoplasms / Q000473:pathology / Q000532:radiotherapy; D006258:Head and Neck Neoplasms / Q000473:pathology / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000150:complications / Q000473:pathology / Q000532:radiotherapy*; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000628:therapy; D009381:Neoplasms, Radiation-Induced / Q000473:pathology* / Q000628:therapy; D010157:Palatal Neoplasms / Q000473:pathology / Q000532:radiotherapy; D012509:Sarcoma / Q000473:pathology* / Q000628:therapy; D014062:Tongue Neoplasms / Q000473:pathology / Q000532:radiotherapy