title: Senile EBV-associated B-cell lymphoproliferative disorder of prepatellar bursa in an elderly patient with multifocal urate arthropathy.
abstract: We report a case of an EBV-associated high grade B-cell lymphoproliferative disorder occurring in the synovial membrane of an elderly patient with gout arthropathy. The EBV-infected B-cells displayed a pattern of viral gene expression (EBNA2+/LMP1+) typically seen during primary EBV-infection and in lymphoproliferations occurring in immunosuppressed individuals. This case conforms to senile EBV-associated lymphoproliferative disorders previously reported only in Japanese patients. We suggest that an impaired EBV-specific T-cell immunity, local or systemic, may play a role in the development of this disorder and that chronic diseases such as gout may be contributing factors.
authors.affiliation: Institute for Pathology, University of Leipzig, Leipzig, Germany.
authors.forename: Susanna
authors.initials: S
authors.lastname: Mueller
authors.forename: Thomas
authors.initials: T
authors.lastname: Aigner
authors.forename: Jochen
authors.initials: J
authors.lastname: Haag
authors.forename: Rene
authors.initials: R
authors.lastname: Schwarz
authors.forename: Gerald
authors.initials: G
authors.lastname: Niedobitek
mesh_terms: D000368:Aged; D015210:Arthritis, Gouty / Q000150:complications*; D001402:B-Lymphocytes / Q000821:virology*; D002062:Bursitis / Q000150:complications* / Q000473:pathology; D004854:Herpesvirus 4, Human / Q000302:isolation & purification*; D006801:Humans; D007719:Knee Joint; D016393:Lymphoma, B-Cell / Q000150:complications / Q000821:virology; D016403:Lymphoma, Large B-Cell, Diffuse / Q000150:complications / Q000821:virology; D008232:Lymphoproliferative Disorders / Q000150:complications* / Q000821:virology*; D008297:Male