The role of the collagen matrix in skeletal fragility.
The collagen network in bone provides resistance against fracture and may be susceptible to changes with aging and disease. This review identifies the changes in quality of collagen matrix as contributors to bone fragility. With aging and in diabetes, cross-links accumulate in bone collagen as a result of nonenzymatic glycation and consequently impair matrix properties, increasing bone fragility. Cell-culture and animal studies suggest that the accumulation of cross-links induced by nonenzymatic glycation may be related to a reduction in bone turnover resulting from the altered responses of osteoblasts and osteoclasts to advanced glycation end products.
Vashishth
Deepak
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Center of Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY 12180, USA. vashid@rpi.edu
D000375:Aging; D000818:Animals; D001842:Bone and Bones / Q000503:physiopathology* / Q000648:ultrastructure; D003094:Collagen / Q000378:metabolism*; D050723:Fractures, Bone / Q000209:etiology* / Q000503:physiopathology; D017127:Glycation End Products, Advanced; D006801:Humans; D010012:Osteogenesis / Q000502:physiology*; D012863:Skeleton
D017127:Glycation End Products, Advanced; D003094:Collagen