title: Compensatory mutation partially restores fitness and delays reversion of escape mutation within the immunodominant HLA-B*5703-restricted Gag epitope in chronic human immunodeficiency virus type 1 infection.
abstract: HLA-B*5703 is associated with effective immune control in human immunodeficiency virus type 1 (HIV-1) infection. Here we describe an escape mutation within the immunodominant HLA-B*5703-restricted epitope in chronic HIV-1 infection, KAFSPEVIPMF (Gag 162-172), and demonstrate that this mutation reduces viral replicative capacity. Reversion of this mutation following transmission to HLA-B*5703-negative recipients was delayed by the compensatory mutation S165N within the same epitope. These data may help explain the observed association between HLA-B*5703 and long-term control of viremia.
authors.affiliation: Department of Pediatrics, University of Oxford, Peter Medawar Building for Pathogen Research, South Parks Rd., Oxford OX1 3SY, United Kingdom.
authors.forename: Hayley
authors.initials: H
authors.lastname: Crawford
authors.forename: Julia G
authors.initials: JG
authors.lastname: Prado
authors.forename: Alasdair
authors.initials: A
authors.lastname: Leslie
authors.forename: Stéphane
authors.initials: S
authors.lastname: Hué
authors.forename: Isobella
authors.initials: I
authors.lastname: Honeyborne
authors.forename: Sharon
authors.initials: S
authors.lastname: Reddy
authors.forename: Mary
authors.initials: M
authors.lastname: van der Stok
authors.forename: Zenele
authors.initials: Z
authors.lastname: Mncube
authors.forename: Christian
authors.initials: C
authors.lastname: Brander
authors.forename: Christine
authors.initials: C
authors.lastname: Rousseau
authors.forename: James I
authors.initials: JI
authors.lastname: Mullins
authors.forename: Richard
authors.initials: R
authors.lastname: Kaslow
authors.forename: Paul
authors.initials: P
authors.lastname: Goepfert
authors.forename: Susan
authors.initials: S
authors.lastname: Allen
authors.forename: Eric
authors.initials: E
authors.lastname: Hunter
authors.forename: Joseph
authors.initials: J
authors.lastname: Mulenga
authors.forename: Photini
authors.initials: P
authors.lastname: Kiepiela
authors.forename: Bruce D
authors.initials: BD
authors.lastname: Walker
authors.forename: Philip J R
authors.initials: PJ
authors.lastname: Goulder
mesh_terms: D000595:Amino Acid Sequence; D015683:Gene Products, gag / Q000145:classification / Q000235:genetics / Q000276:immunology*; D015658:HIV Infections / Q000276:immunology*; D015497:HIV-1 / Q000235:genetics / Q000378:metabolism*; D015235:HLA-B Antigens / Q000235:genetics / Q000276:immunology*; D006801:Humans; D016056:Immunodominant Epitopes; D016013:Likelihood Functions; D009154:Mutation; D010802:Phylogeny; D014779:Virus Replication
chemical_list: D015683:Gene Products, gag; D015235:HLA-B Antigens; D016056:Immunodominant Epitopes