Designer receptors for every body.
Using a directed evolution approach, researchers demonstrate a way of creating 'designer' receptors that are specifically activated by a ligand with no other biological activity in the cell.
Kaganman
Irene
I
D000818:Animals; D002461:Cell Line, Transformed; D003024:Clozapine / Q000031:analogs & derivatives / Q000378:metabolism; D019020:Directed Molecular Evolution; D006801:Humans; D009474:Neurons / Q000378:metabolism; D051381:Rats; D043587:Receptor, Muscarinic M3 / Q000378:metabolism; D043562:Receptors, G-Protein-Coupled / Q000235:genetics*
D043587:Receptor, Muscarinic M3; D043562:Receptors, G-Protein-Coupled; D003024:Clozapine; C079149:clozapine N-oxide