title: Low mannose-binding lectin concentration is associated with severe infection in patients with hematological cancer who are undergoing chemotherapy.
abstract: BACKGROUND
  Mannose-binding lectin (MBL) is a serum lectin involved in innate immune response. Low serum MBL concentration may constitute a risk factor for infection in patients receiving myelosuppressive chemotherapy.
  
  
  METHODS
  We conducted a prospective, observational study that assessed MBL concentration as a risk factor for infection in patients with hematological malignancy who were hospitalized to undergo at least 1 chemotherapy cycle. MBL deficiency was defined using an algorithm that considered the serum MBL concentration and the MBL genotype. The primary end point was the ratio of duration of febrile neutropenia to the duration of neutropenia. Secondary end points included the incidence of severe infection (e.g., sepsis, pneumonia, bacteremia, and invasive fungal infection). Logistic regression analysis was conducted, and Fisher's exact test was used to analyze binary outcomes, and Kaplan-Meier estimates and log rank tests were used for time-to-event variables.
  
  
  RESULTS
  We analyzed 255 patients who received 569 cycles of chemotherapy. The median duration of neutropenia per cycle was 7 days (interquartile range, 0-13 days). Sixty-two patients (24%) were found to have MBL deficiency. Febrile neutropenia occurred at least once in 200 patients. No difference in the primary outcome was seen. The incidence of severe infection was higher among MBL-deficient patients than among non-MBL-deficient patients (1.96 vs. 1.34 cases per 100 days for analysis of all patients [P=.008] and 1.85 vs. 0.94 cases per 100 days excluding patients with acute leukemia [P<.001]).
  
  
  CONCLUSIONS
  MBL deficiency does not predispose adults with hematological cancer to more-frequent or more-prolonged febrile episodes during myelosuppressive chemotherapy, but MBL-deficient patients have a greater number of severe infections and experience their first severe infection earlier, compared with nondeficient patients.
authors.affiliation: Infectious Diseases Department, Institut Jules Bordet, Brussels, Belgium.
authors.forename: M
authors.initials: M
authors.lastname: Vekemans
authors.forename: J
authors.initials: J
authors.lastname: Robinson
authors.forename: A
authors.initials: A
authors.lastname: Georgala
authors.forename: C
authors.initials: C
authors.lastname: Heymans
authors.forename: F
authors.initials: F
authors.lastname: Muanza
authors.forename: M
authors.initials: M
authors.lastname: Paesmans
authors.forename: J
authors.initials: J
authors.lastname: Klastersky
authors.forename: M
authors.initials: M
authors.lastname: Barette
authors.forename: N
authors.initials: N
authors.lastname: Meuleman
authors.forename: F
authors.initials: F
authors.lastname: Huet
authors.forename: T
authors.initials: T
authors.lastname: Calandra
authors.forename: S
authors.initials: S
authors.lastname: Costantini
authors.forename: A
authors.initials: A
authors.lastname: Ferrant
authors.forename: F
authors.initials: F
authors.lastname: Mathissen
authors.forename: M
authors.initials: M
authors.lastname: Axelsen
authors.forename: O
authors.initials: O
authors.lastname: Marchetti
authors.forename: M
authors.initials: M
authors.lastname: Aoun
mesh_terms: D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects*; D004198:Disease Susceptibility / Q000097:blood* / Q000276:immunology; D005260:Female; D019337:Hematologic Neoplasms / Q000150:complications / Q000188:drug therapy; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D037601:Mannose-Binding Lectin / Q000097:blood* / Q000172:deficiency*; D008875:Middle Aged; D009503:Neutropenia / Q000139:chemically induced; D011014:Pneumonia / Q000097:blood* / Q000276:immunology; D011446:Prospective Studies; D012307:Risk Factors; D018805:Sepsis / Q000097:blood* / Q000276:immunology
chemical_list: D000970:Antineoplastic Agents; D037601:Mannose-Binding Lectin