A new cross-talk pathway between the renal tubule and its own glomerulus.
The connecting tubule (CNT) of superficial nephrons comes into close contact with the corresponding afferent arteriole of its own glomerulus. Ren et al. demonstrate that this close anatomical configuration is also the site for cross-talk between the CNT and the afferent arteriole. This mechanism is triggered by the entry of sodium through amiloride sodium channels and may antagonize tubuloglomerular feedback.
Capasso
G
G
Department of Internal Medicine, Second University of Naples, Naples, Italy. gb.capasso@unina2.it
D000584:Amiloride / Q000494:pharmacology; D000818:Animals; D001160:Arterioles / Q000502:physiology; D005246:Feedback / Q000187:drug effects; D007668:Kidney / Q000033:anatomy & histology / Q000098:blood supply; D007678:Kidney Glomerulus / Q000502:physiology*; D007684:Kidney Tubules / Q000502:physiology*; D008954:Models, Biological; D011817:Rabbits; D026941:Sodium Channel Blockers / Q000494:pharmacology; D012965:Sodium Chloride / Q000008:administration & dosage / Q000494:pharmacology
D026941:Sodium Channel Blockers; D012965:Sodium Chloride; D000584:Amiloride