Incidental granular parakeratotic cornification in carcinomas.
Granular parakeratosis is histopathologically recognized by the presence of parakeratotic corneocytes housing keratohyaline granules. Similar to acantholytic dyskeratosis and epidermolytic hyperkeratosis, it may histopathologically represent a diagnostic finding in a specific dermatosis, one of the diagnostic features in a solitary keratosis or an incidental finding. Granular parakeratosis as an incidental finding has been reported in association with various dermatoses. This report expands the concept of granular parakeratosis as an incidental histopathologic feature by describing it in carcinomas. In addition, we also present the phenomenon of retained keratohyaline granules unaccompanied by a nucleus within corneocytes, ie, granular orthokeratotic cornification.
Resnik
Kenneth S
KS
Institute for Dermatopathology in Conshohocken, Conshohocken, Pennsylvania 19428, USA. kresnik@ameripath.com
DiLeonardo
Mario
M
D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000473:pathology*; D002278:Carcinoma in Situ / Q000473:pathology; D002280:Basal Cell Carcinoma / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000473:pathology; D003594:Cytoplasmic Granules / Q000473:pathology; D005260:Female; D006801:Humans; D015603:Keratinocytes / Q000473:pathology*; D007636:Keratoacanthoma / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009381:Neoplasms, Radiation-Induced / Q000473:pathology*; D012878:Skin Neoplasms / Q000473:pathology*; D014466:Ultraviolet Rays / Q000009:adverse effects