Prevalence, characteristics, and molecular epidemiology of macrolide and fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae at five tertiary-care hospitals in Korea.
The genes erm(B), mef(A), and both erm(B) and mef(A) were identified in 42.6, 10.1, and 47.3%, respectively, of the erythromycin-resistant Streptococcus pneumoniae isolates. Of the strains, 3.8% were nonsusceptible to levofloxacin and had 1 to 6 amino acid changes in the quinolone resistance-determining region, including a new mutation, Asn94Ser, in the product of parC. Levofloxacin with reserpine was highly specific for efflux screening.
Shin
Jeong Hwan
JH
Department of Laboratory Medicine, College of Medicine, Inje University, 633-165 Gaegeum-Dong Busanjin-Gu, Busan, 614-110, Korea. jhsmile@inje.ac.kr
Jung
Hee Jung
HJ
Kim
Hye Ran
HR
Jeong
Joseph
J
Jeong
Seok Hoon
SH
Kim
Sunjoo
S
Lee
Eun Yup
EY
Lee
Jeong Nyeo
JN
Chang
Chulhun Ludgerus
CL
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D017714:Community-Acquired Infections / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology; D004269:DNA, Bacterial; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D004917:Erythromycin / Q000494:pharmacology; D024841:Fluoroquinolones / Q000494:pharmacology; D005798:Genes, Bacterial; D006761:Hospitals; D006801:Humans; D007723:Korea / Q000453:epidemiology; D064704:Levofloxacin; D018942:Macrolides / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D017720:Molecular Epidemiology / Q000379:methods*; D009154:Mutation; D015242:Ofloxacin / Q000494:pharmacology; D011008:Pneumococcal Infections / Q000453:epidemiology / Q000382:microbiology; D016133:Polymerase Chain Reaction; D015995:Prevalence; D012110:Reserpine / Q000494:pharmacology; D012141:Respiratory Tract Infections / Q000453:epidemiology / Q000382:microbiology; D012189:Retrospective Studies; D013296:Streptococcus pneumoniae / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification
D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial; D024841:Fluoroquinolones; D018942:Macrolides; D004917:Erythromycin; D064704:Levofloxacin; D012110:Reserpine; D015242:Ofloxacin