Chirality--a new era of therapeutics.
To develop the newer pharmaceuticals and to spur the strong growth, being a general property of 'handedness', chirality plays a major role. The Easson-Stedman principle shows the differences in the biological activity between enantiomers resulted from selective reactivity of one enantiomer with its receptor. It helps to improve the pharmacokinetic properties and to remove undesirable side effects by virtue of the unique activity of enantiomers. Racemic switching and marketing drug combinations are used as tools for drug life-cycle management and to redevelop racemic mixtures as single enantiomers.
Agrawal
Y K
YK
Institute of Pharmacy, NIRMA University, S. G. Highway, Chharodi, Ahmedabad - 382 481, India. drykagrawal@yahoo.com
Bhatt
H G
HG
Raval
H G
HG
Oza
P M
PM
Gogoi
P J
PJ
D002626:Chemistry, Pharmaceutical / Q000379:methods*; D015195:Drug Design; D008968:Molecular Conformation; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D013237:Stereoisomerism
D004364:Pharmaceutical Preparations