[Androgen deficiency in women: indication and risks of testosterone or DHEA treatment].
Androgen deficiency syndrome is defined by impaired well being and libido in women with adequate estrogenization and low levels of total serum testosterone (T). The causes of low T levels are discussed. Seven placebo controlled studies have shown that percutaneous administration of T is able to increase sexual activity and libido in ovariectomized women (5 studies), after hypophysectomy and in natural menopause. DHEA (50 mg/d) is beneficial only in women with Addison disease or after hypophysectomy but not in natural adrenopause. Other beneficial and side effects of androgenotherapy are discussed in particular the breast cancer risk.
Martin-Du Pan
Rémy
R
martindupan@bluewin.ch
D000309:Adrenal Insufficiency / Q000150:complications / Q000188:drug therapy*; D000728:Androgens / Q000627:therapeutic use; D019314:Dehydroepiandrosterone Sulfate / Q000627:therapeutic use; D005260:Female; D006801:Humans; D012735:Sexual Dysfunction, Physiological / Q000188:drug therapy / Q000209:etiology; D013739:Testosterone / Q000627:therapeutic use
D000728:Androgens; D013739:Testosterone; D019314:Dehydroepiandrosterone Sulfate