title: Chemoenzymatic synthesis and antimicrobial activity evaluation of monogalactosyl diglycerides.
abstract: Monogalactosyl diglycerides with medium to long fatty acid acyl chains, were prepared and examined for antimicrobial activity against Gram positive, Gram negative bacteria and fungi. The study of their in vitro antimicrobial activity confirms the significant activity of some monogalactosyl diacylglycerol analogues and establishes for the galactose series that the 1,2-disubstitution and the octanoyl chain are the proper structural features for the maximum activity.
authors.affiliation: Department of Pharmaceutical Sciences, University of Trieste, P.zle Europa, 1, 34127 Trieste, TS, Italy. cateni@univ.trieste.it
authors.forename: Francesca
authors.initials: F
authors.lastname: Cateni
authors.forename: Paolo
authors.initials: P
authors.lastname: Bonivento
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Procida
authors.forename: Marina
authors.initials: M
authors.lastname: Zacchigna
authors.forename: Luciana Gabrielli
authors.initials: LG
authors.lastname: Favretto
authors.forename: Giuditta
authors.initials: G
authors.lastname: Scialino
authors.forename: Elena
authors.initials: E
authors.lastname: Banfi
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D004075:Diglycerides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D005658:Fungi / Q000187:drug effects; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests
chemical_list: D000890:Anti-Infective Agents; D004075:Diglycerides