title: Phenylpropanoic acid derivatives bearing a benzothiazole ring as PPARdelta-selective agonists.
abstract: To find novel PPARdelta-selective agonists, we designed and synthesized phenylpropanoic acid derivatives bearing 6-substituted benzothiazoles. Optimization of this series led to the identification of a potent and selective PPARdelta agonist 17. Molecular modeling suggested that compound 17 occupies the Y-shaped pocket of PPARdelta appropriately.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, Aichi 467-8603, Japan.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Fujieda
authors.forename: Shinya
authors.initials: S
authors.lastname: Usui
authors.forename: Takayoshi
authors.initials: T
authors.lastname: Suzuki
authors.forename: Hidehiko
authors.initials: H
authors.lastname: Nakagawa
authors.forename: Michitaka
authors.initials: M
authors.lastname: Ogura
authors.forename: Makoto
authors.initials: M
authors.lastname: Makishima
authors.forename: Naoki
authors.initials: N
authors.lastname: Miyata
mesh_terms: D052160:Benzothiazoles / Q000737:chemistry*; D006801:Humans; D008958:Models, Molecular; D047494:PPAR delta / Q000819:agonists*; D010666:Phenylpropionates / Q000494:pharmacology*; D011743:Pyrimidines / Q000494:pharmacology
chemical_list: D052160:Benzothiazoles; D047494:PPAR delta; D010666:Phenylpropionates; D011743:Pyrimidines; C006253:pirinixic acid