Supramolecular medicinal chemistry: mixed-ligand coordination complexes.
We report on the supramolecular synthesis and characterization of examples from three series of mixed-ligand coordination complexes composed of copper(II), a drug, and an ancillary ligand (AL). Particularly, we demonstrate how the judicious choice of an ancillary ligand affords a large degree of control over the relative lipophilicity/hydrophilicity of the complex in relation to the uncomplexed drug molecule. Furthermore, we demonstrate several important factors to consider in the design of such complexes such as the additive-constitutive nature of the partition coefficient of the ancillary ligand and the relative size of the two types of ligands.
Ma
Zhenbo
Z
Department of Chemistry, Brown University, 324 Brook Street, Providence, Rhode Island 02912, USA.
Moulton
Brian
B
D002626:Chemistry, Pharmaceutical; D003460:Crystallization; D018360:Crystallography, X-Ray; D008024:Ligands; D008958:Models, Molecular; D015394:Molecular Structure; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D033362:Powder Diffraction; D012995:Solubility
D008024:Ligands; D004364:Pharmaceutical Preparations