title: Evaluation of optic nerve head configuration in various types of optic neuropathy with Heidelberg Retina Tomograph.
abstract: OBJECTIVE
  To test whether Heidelberg Retina Tomograph (HRT) is applicable to assess the optic nerve head (ONH) configuration of the atrophic phase of non-glaucomatous optic neuropathy when a default set of the reference plane is used.
  
  
  METHODS
  Ten eyes with non-arteritic anterior ischaemic optic neuropathy (NAION), 17 eyes with Leber's hereditary optic neuropathy (LHON), 40 eyes with compressive optic neuropathy (CON) owing to chiasmal tumour, and 241 eyes of control individuals were examined with HRT using the default reference plane. The global values of HRT parameters were evaluated among the groups of patients and controls. The sectoral measurements of the eyes with LHON and CON were compared with controls. To eliminate the influence of disc size and age on HRT measurements, eyes with disc area- and age-matched normal controls were used for comparison with eyes with NAION and LHON.
  
  
  RESULTS
  Cup parameters in eyes with NAION were similar to those in controls. The retinal nerve fibre layer (RNFL) thickness was significantly thinner in eyes with NAION than that of controls. The eyes with LHON had significantly larger cup parameters, smaller rim volume, and thinner mean RNFL thickness than controls. Eyes with CON had significantly larger rim area and smaller cup parameters but similar RNFL thickness compared with controls.
  
  
  CONCLUSIONS
  When the default reference plane is used, HRT can measure the ONH configuration in eyes with NAION and LHON as expected. However, caution must be made to interpret the parameters obtained from the eyes with CON.
authors.affiliation: Division of Ophthalmology, Department of Organs Therapeutics, Kobe University Graduate School of Medicine, Chuo-ku, Kobe, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Nagai-Kusuhara
authors.forename: M
authors.initials: M
authors.lastname: Nakamura
authors.forename: A
authors.initials: A
authors.lastname: Kanamori
authors.forename: Y
authors.initials: Y
authors.lastname: Nakanishi
authors.forename: S
authors.initials: S
authors.lastname: Kusuhara
authors.forename: Akira
authors.initials: A
authors.lastname: Negi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology*; D009887:Ophthalmoscopy / Q000379:methods*; D029242:Optic Atrophy, Hereditary, Leber / Q000473:pathology; D009898:Optic Disk / Q000473:pathology*; D009901:Optic Nerve Diseases / Q000473:pathology*; D018917:Optic Neuropathy, Ischemic / Q000473:pathology; D012016:Reference Values; D015203:Reproducibility of Results; D012160:Retina / Q000473:pathology*; D055815:Young Adult