title: [Three advanced gastric cancer patients successfully treated by combination therapy of paclitaxel and cisplatin].
abstract: We report 3 gastric cancer patients with peritoneal dissemination who were successfully treated with weekly paclitaxel and cisplatin. The patients were 2 men and 1 woman from 57 to 70 years in age. The histological types were 2 poorly-differentiated adenocarcinomas and 1 moderately-differentiated adenocarcinoma. Intravenous infusion of PTX (80 mg/m(2)) and CDDP (25 mg/m(2)) after short premedication was continued for 3 weeks followed by 1 week rest. Ascites improved only after administration of 1 course in all patients.PTX/CDDP is thought to be an effective chemotherapy showing acceptable toxicity against advanced gastric cancer with ascites.
authors.affiliation: Dept. of Surgery, Nippon Medical School, Chiba Hokusou Hospital.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Yamada
authors.forename: Noritake
authors.initials: N
authors.lastname: Tanaka
authors.forename: Kimiyoshi
authors.initials: K
authors.lastname: Yokoi
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Ishikawa
authors.forename: Tomoko
authors.initials: T
authors.lastname: Seya
authors.forename: Kouji
authors.initials: K
authors.lastname: Horiba
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Kanazawa
authors.forename: Takashi
authors.initials: T
authors.lastname: Shirakawa
authors.forename: Keiichi
authors.initials: K
authors.lastname: Ohkawa
authors.forename: Hidenori
authors.initials: H
authors.lastname: Kudoh
authors.forename: Michihiro
authors.initials: M
authors.lastname: Koizumi
authors.forename: Masato
authors.initials: M
authors.lastname: Yoshioka
authors.forename: Seiichi
authors.initials: S
authors.lastname: Shinji
authors.forename: Miwako
authors.initials: M
authors.lastname: Katsuta
authors.forename: Kiyohiko
authors.initials: K
authors.lastname: Yamashita
authors.forename: Takashi
authors.initials: T
authors.lastname: Tajiri
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000556:secondary; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007970:Leukopenia / Q000139:chemically induced; D008297:Male; D008875:Middle Aged; D017239:Paclitaxel / Q000008:administration & dosage; D010534:Peritoneal Neoplasms / Q000188:drug therapy / Q000556:secondary; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology
chemical_list: D017239:Paclitaxel; D002945:Cisplatin