[Pulmonary hypertension and right ventricular failure. Part VII. Epidemiology, risk factors, and pathogenesis of primary (idiopathic) pulmonary arterial hypertension].
In a series of articles the authors discuss literature data concerning epidemiology of pulmonary arterial hypertension (PAH), its modern classification; peculiarities of its pathogenesis and analysis of results of epidemiological and cohort studies. Rate of new cases of PAH is 1-2, prevalence - approximately 15 cases per million of adult population. This part contains detailed discussion of definite, probable and possible risk factors of PAH which comprise some drugs (anorexigens, amphetamines, meta- amphetamines), HIV infection, collagen vascular diseases, congenital systemic-to-pulmonary shunts, portal hypertension, and some hematological diseases. Analysis of literature data concerning interaction of genetic predisposition and factors of internal and external environment in pathogenesis of PAH as well as presentation of direct and indirect proofs of key role of serotonin in pathogenesis of PAH of various genesis are also included.
Batyraliev
T A
TA
Makhmutkhodzhaev
S A
SA
Esinci
E
E
Pataraia
S A
SA
Pershukov
I V
IV
Sidorenko
B A
BA
Preobrazhenskiĭ
D V
DV
D006801:Humans; D006976:Hypertension, Pulmonary / Q000150:complications / Q000453:epidemiology* / Q000209:etiology*; D012307:Risk Factors; D018497:Ventricular Dysfunction, Right / Q000209:etiology*