The effect of platelet-rich plasma on early and late bone healing: an experimental study in goats.
Four round critical-size defects were made in the foreheads of 20 goats. The defects were filled with autogenous particulate cancellous bone, in which 1 ml of platelet-rich plasma (PRP) was added in two of the four defects of each goat. The goats were divided into four subgroups of five goats each, which were killed after 1, 2, 6 and 12 weeks. The results of histologic and histomorphometric examination showed that early and late bone healing was not enhanced when PRP was used.
Mooren
R E C M
RE
Department of Oral and Maxillofacial Surgery, University Medical Centre Nijmegen, The Netherlands. r.mooren@chello.nl
Merkx
M A W
MA
Bronkhorst
E M
EM
Jansen
J A
JA
Stoelinga
P J W
PJ
D000818:Animals; D001847:Bone Diseases / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D001862:Bone Resorption / Q000473:pathology; D016025:Bone Transplantation / Q000379:methods / Q000473:pathology; D005260:Female; D005624:Frontal Bone / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D015726:Giant Cells / Q000473:pathology; D006041:Goats; D008214:Lymphocytes / Q000473:pathology; D010010:Osteoclasts / Q000473:pathology; D010011:Osteocytes / Q000473:pathology; D010012:Osteogenesis / Q000502:physiology; D053657:Platelet-Rich Plasma / Q000502:physiology; D013997:Time Factors; D014945:Wound Healing / Q000502:physiology