Biological studies of new organotin(IV) complexes of thioamide ligands.
New organotin(IV) complexes with heterocyclic thioamides 2-mercapto-benzothiazole (Hmbzt), 5-chloro-2-mercapto-benzothiazole (Hcmbzt) and 2-mercapto-benzoxazole (Hmbzo) of formulae [(C(6)H(5))(3)Sn(mbzt)] (1), [(C(6)H(5))(3)Sn(cmbzt)] (3) and [(C(6)H(5))(2)Sn(cmbzt)(2)] (4), together with the already known [(C(6)H(5))(3)Sn(mbzo)] (2), [(n-C(4)H(9))(2)Sn(cmbzt)(2)] (5) and [(CH(3))(2)Sn(cmbzt)(2)] (6) were used to study their influence on the peroxidation of oleic acid. The influence of complexes (3)-(6) upon peroxidation of oleic acid showed that the formation of reactive radicals caused the initiation of the chain radical oxidation of the substrate. The influence of complexes (1)-(6) upon the catalytic peroxidation of linoleic acid by the enzyme lipoxygenase (LOX) was also studied and compared to those of cisplatin. Compounds (1)-(6) were finally tested for in vitro cytotoxicity against leiomyosarcoma cells.
Xanthopoulou
Marianna N
MN
Inorganic and Analytical Chemistry, Department of Chemistry, University of Ioannina, 45110 Ioannina, Greece. me00635@cc.uoi.gr
Hadjikakou
Sotiris K
SK
Hadjiliadis
Nick
N
Milaeva
Elena R
ER
Gracheva
Julia A
JA
Tyurin
Vladimir Yu
VY
Kourkoumelis
Nikolaos
N
Christoforidis
Kostantinos C
KC
Metsios
Apostolos K
AK
Karkabounas
Spyros
S
Charalabopoulos
Konstantinos
K
D002384:Catalysis; D019787:Linoleic Acid / Q000737:chemistry; D015227:Lipid Peroxidation; D009947:Organotin Compounds / Q000737:chemistry / Q000494:pharmacology*; D010084:Oxidation-Reduction; D013854:Thioamides / Q000737:chemistry / Q000494:pharmacology*
D009947:Organotin Compounds; D013854:Thioamides; D019787:Linoleic Acid