Surgical outcome of superficial and deep Castleman disease.
BACKGROUND
Castleman disease is a rare lymphoproliferative disease of low malignant potential occurring in two forms, unicentric and multicentric. Surgery, chemotherapy, immunotherapy and radiation therapy have all been used to manage the disease. In this study, we evaluate whether the site of the lesions, that is, superficial or deep, influences the surgical outcome.


METHODS
We retrospectively reviewed the records of 20 patients operated on for Castleman disease from 1994 to 2003, of whom 11 patients had superficial disease and 9 had deep lesions. The end-points of this study were survival and recurrence.


RESULTS
Of the 20 patients, 19 had unicentric (cervical in 8, mediastinal in 5, retroperitoneal in 2, axillary in 2, hepatic in 1, and mesenteric in 1) and 1 had multicentric Castleman disease. Among 19 patients who had complete resection (18 with unicentric and 1 with multicentric disease), there has been no evidence of recurrence.


CONCLUSIONS
Whether Castleman disease is superficial or deep has no effect on surgical outcome as long as resection is complete.
Chen
Chih-Hao
CH
Department of Surgery, Mackay Memorial Hospital, Taipei City, Taiwan.
Liu
Hung-Chang
HC
Tung
Kwang-Yi
KY
Lee
Jie-Jen
JJ
Liu
Chien-Liang
CL
Liu
Tsang-Pai
TP
D000293:Adolescent; D000328:Adult; D000368:Aged; D005871:Castleman Disease / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D002648:Child; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome