title: Successful long-term weight maintenance: a 2-year follow-up.
abstract: OBJECTIVE
  To find factors associated with successful weight maintenance (WM) in overweight and obese subjects after a very low-calorie diet (VLCD).
  
  
  METHODS
  Subjects (133) followed a VLCD (2.1 MJ/d) for 6 weeks in a free-living situation. Of these, 103 subjects (age, 49.6 +/- 9.7 years; BMI, 30.9 +/- 3.8 kg/m(2)) completed the following 2-year WM period. Body weight (BW), body composition, leptin concentration, attitude toward eating, and physical activity were determined right before (t0) and after (t1) the VLCD, after 3 months (t2), after 1 year (t3), after 1.5 years (t4), and after 2 years (t5).
  
  
  RESULTS
  BW loss during VLCD was 7.2 +/- 3.1 kg. After 2 years, follow-up BW regain was 69.0 +/- 98.4%. After 2 years of WM, 13 subjects were successful (<10% BW regain), and 90 were unsuccessful (>10% BW regain). At baseline, these groups were significantly different in BMI (33.7 +/- 4.7 vs. 30.5 +/- 3.5 kg/m(2), respectively; p < 0.05) and fat mass (38.3 +/- 9.8 vs. 32.1 +/- 8.3 kg, p < 0.05). Successful subjects increased their dietary restraint significantly more during the whole study period (dietary restraint score, -4.9 +/- 4.4 vs. -2.1 +/- 3.8). Furthermore, %BW regain was associated with the amount of percentage body fat lost during VLCD, which indicates that the more fat lost, the better the WM, suggesting a fat free mass-sparing effect.
  
  
  CONCLUSIONS
  Characteristics such as the ability to increase dietary restraint and maintain this high level of restraint, fat free mass sparing, and a relatively high baseline BMI and fat mass were associated with successful long-term WM (<10% regain after 2 years).
authors.affiliation: Department of Human Biology, Maastricht University, P.O. Box 616, NL-6200 MD Maastricht, The Netherlands.
authors.forename: Neeltje
authors.initials: N
authors.lastname: Vogels
authors.forename: Margriet S
authors.initials: MS
authors.lastname: Westerterp-Plantenga
mesh_terms: D000328:Adult; D001290:Attitude; D001823:Body Composition; D001835:Body Weight; D004032:Diet; D004435:Eating / Q000502:physiology* / Q000523:psychology; D015444:Exercise; D005500:Follow-Up Studies; D006801:Humans; D020738:Leptin / Q000097:blood; D008875:Middle Aged; D009426:Netherlands; D011795:Surveys and Questionnaires; D013997:Time Factors; D015431:Weight Loss / Q000502:physiology*
chemical_list: D020738:Leptin