[Molecular mechanisms of cytotoxic effect of alpha-toxin of Staphylococcus aureus].
Mechanism of action of Staphylococcus aureus alpha-toxin has been reviewed. Data about molecular transformations during cytolytic action, dimensional structure of monomeric and oligomeric toxin, its characteristics in different molecular states are presented. Data about defects of oligomerization due to modification or site-induced mutagenesis are discussed.
Khaziev
A F
AF
Mikhaĭlova
N A
NA
D000818:Animals; D001427:Bacterial Toxins / Q000737:chemistry; D002462:Cell Membrane / Q000378:metabolism; D005098:Exotoxins / Q000737:chemistry / Q000502:physiology*; D006460:Hemolysin Proteins / Q000737:chemistry / Q000502:physiology*; D006801:Humans; D052899:Pore Forming Cytotoxic Proteins / Q000737:chemistry / Q000502:physiology*; D013203:Staphylococcal Infections / Q000382:microbiology; D013211:Staphylococcus aureus / Q000201:enzymology*
D001427:Bacterial Toxins; D005098:Exotoxins; D006460:Hemolysin Proteins; D052899:Pore Forming Cytotoxic Proteins; C021091:staphylococcal alpha-toxin