title: [Laryngopharyngeal reflux].
abstract: Laryngopharyngeal reflux (LPR) or reflux laryngitis refers to the backflow of stomach contents into the larynx and hypopharynx. LPR is increasingly cited as the cause of laryngeal signs and symptoms such as globus sensation, hoarseness, chronic cough, chronic throat clearing, and throat pain. The diagnosis of LPR is often based on the presenting symptoms and associated laryngeal signs. An empiric trial of double-dose proton pump inhibitors (PPIs) has been recommended as a first line therapy in patients with suspected LPR. However, recent systemic review has shown no benefit of PPIs over placebo in the treatment of LPR. Clearly, more well designed, prospective large scale trials are warranted in the future.
authors.affiliation: Department of Gastroenterolgy and Hematology, Hokkaido University Graduate School of Medicine.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Takeda
authors.forename: Nobuhiko
authors.initials: N
authors.lastname: Oridate
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Shimizu
authors.forename: Mototsugu
authors.initials: M
authors.lastname: Kato
authors.forename: Masahiro
authors.initials: M
authors.lastname: Asaka
authors.forename: Satoshi
authors.initials: S
authors.lastname: Fukuda
authors.forename: Junji
authors.initials: J
authors.lastname: Yamamoto
mesh_terms: D004791:Enzyme Inhibitors / Q000627:therapeutic use; D050782:Esophageal pH Monitoring; D005764:Gastroesophageal Reflux / Q000175:diagnosis / Q000503:physiopathology* / Q000628:therapy; D006801:Humans; D007818:Laryngeal Diseases / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D007828:Laryngoscopy; D010608:Pharyngeal Diseases / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D054328:Proton Pump Inhibitors
chemical_list: D004791:Enzyme Inhibitors; D054328:Proton Pump Inhibitors