title: Rostral anterior cingulate cortex activity in the theta band predicts response to antidepressive medication.
abstract: During the last 10 years the knowledge about rostral anterior cingulate cortex (ACC) activity in major depression has substantially increased. Several groups have independently described a relationship between resting activity in this area and response to antidepressant treatment. We have recently confirmed a relationship between resting activity of rostral ACC activity and response in a group of 20 patients with major depression using resting theta activity. In this earlier study regions of interest (ROI) were defined in order to establish regional specificity. Differences between responders and nonresponders were only found in the ACC-ROI, but not in the posterior cingulate region. We have now reanalyzed our data using a whole brain voxelwise approach, in order not to miss any other relevant functional differences. In addition to major differences between responders and nonresponders in the rostral ACC, we have identified a nearby region in the midline orbito-frontal region.
authors.affiliation: Department of Psychiatry, Ludwig-Maximilians-University, Munich, Germany. cmulert@med.uni-muenchen.de
authors.forename: Christoph
authors.initials: C
authors.lastname: Mulert
authors.forename: Georg
authors.initials: G
authors.lastname: Juckel
authors.forename: Michael
authors.initials: M
authors.lastname: Brunnmeier
authors.forename: Susanne
authors.initials: S
authors.lastname: Karch
authors.forename: Gregor
authors.initials: G
authors.lastname: Leicht
authors.forename: Roland
authors.initials: R
authors.lastname: Mergl
authors.forename: Hans-Jürgen
authors.initials: HJ
authors.lastname: Möller
authors.forename: Ulrich
authors.initials: U
authors.lastname: Hegerl
authors.forename: Oliver
authors.initials: O
authors.lastname: Pogarell
mesh_terms: D000928:Antidepressive Agents / Q000008:administration & dosage*; D003863:Depression / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology*; D004569:Electroencephalography / Q000187:drug effects* / Q000379:methods*; D005260:Female; D006179:Gyrus Cinguli / Q000187:drug effects / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care / Q000379:methods; D011379:Prognosis; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D016896:Treatment Outcome
chemical_list: D000928:Antidepressive Agents