title: The relationship between gastric emptying determined by the breath test and H. pylori.
abstract: OBJECTIVE
  Helicobacter pylori infection has been implicated in atrophic gastritis and gastric ulcer disease. However, the relationship between gastric emptying and Helicobacter pylori infection is still unclear.
  
  
  METHODS
  One hundred and two consecutive patients with functional dyspepsia were enrolled in this study (53 Helicobacter pylori positive and 49 negative). Gastric emptying was determined using both the 13C-octanoic acid breath test and the paracetamol absorption test. For grading gastric atrophy, the biopsy samples and serum pepsinogen I/II ratio were used. The relationship between gastric emptying, Helicobacter pylori infection and atrophy grade was investigated.
  
  
  RESULTS
  There was no significant difference in all gastric emptying parameters between Helicobacter pylori positive and negative patients. However, in Helicobacter pylori positive subjects, pepsinogen I/II ratio correlated with atrophy grade, and it also correlated with all parameters of gastric emptying. Especially in the half-emptying time, an important parameter, there was significant correlation with the pepsinogen I/II ratio (R = -0.39, p < 0.01). This finding implies that gastric emptying is delayed according to the degree of gastric atrophy.
  
  
  CONCLUSIONS
  Gastric emptying was not delayed simply according to advanced age, but according to the advance in gastric atrophy.
authors.affiliation: Division of Diabetes, Digestive, and Kidney Disease, Kobe University School of Medicine, Kobe, Japan.
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Ebara
authors.forename: Daisuke
authors.initials: D
authors.lastname: Shirasaka
authors.forename: Nobuo
authors.initials: N
authors.lastname: Aoyama
authors.forename: Masaaki
authors.initials: M
authors.lastname: Kachi
authors.forename: Ikuya
authors.initials: I
authors.lastname: Miki
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Morita
authors.forename: Takao
authors.initials: T
authors.lastname: Tamura
authors.forename: Masato
authors.initials: M
authors.lastname: Kasuga
mesh_terms: D000082:Acetaminophen / Q000493:pharmacokinetics; D000328:Adult; D000368:Aged; D001944:Breath Tests; D002210:Caprylates; D002250:Carbon Radioisotopes; D004415:Dyspepsia / Q000175:diagnosis / Q000503:physiopathology*; D005260:Female; D005746:Gastric Emptying / Q000502:physiology*; D005757:Gastritis, Atrophic / Q000175:diagnosis / Q000503:physiopathology*; D016481:Helicobacter Infections / Q000175:diagnosis / Q000503:physiopathology*; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D008875:Middle Aged; D020116:Pepsinogen A / Q000097:blood; D020115:Pepsinogen C / Q000097:blood; D013223:Statistics as Topic; D013276:Stomach Ulcer / Q000175:diagnosis / Q000503:physiopathology*
chemical_list: D002210:Caprylates; D002250:Carbon Radioisotopes; D000082:Acetaminophen; D020115:Pepsinogen C; D020116:Pepsinogen A; C031492:octanoic acid