Curcumin and cyclopalladated complexes: a recipe for bifunctional biomaterials.
The first examples of binuclear and mononuclear ortho-palladated complexes based on a functionalized 2-phenylquinoline ligand have been synthesized and fully characterized. Conjugating cyclopalladated fragments to curcumin family biologically active beta-diketones gives in one single molecule two different functionalities. The structural variations based on the curcuminoid structure have been tested for their in vitro cytotoxic activity. The activity of complexes comprised of a cyclopalladated fragment conjugated to functionalized bioactive ligands, represents the potential of organometallic systems in generating new bifunctional biomaterials.
Pucci
Daniela
D
Centro di Eccellenza CEMIF.CAL-LASCAMM, CR-INSTM Unità della Calabria, Dipartimento di Chimica, Università della Calabria, Italy. d.pucci@unical.it
Bloise
Rossana
R
Bellusci
Anna
A
Bernardini
Sergio
S
Ghedini
Mauro
M
Pirillo
Sante
S
Valentini
Alessandra
A
Crispini
Alessandra
A
D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D018360:Crystallography, X-Ray; D003474:Curcumin / Q000737:chemistry*; D006801:Humans; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology
D009942:Organometallic Compounds; D003474:Curcumin