title: The bradykinin type 2 receptor BE1 polymorphism and ethnicity influence systolic blood pressure and vascular resistance.
abstract: We examined the effect of -58 C/T and BE1 +9/-9 polymorphisms in the bradykinin B2 receptor gene on forearm vascular resistance (FVR) before and during intrabrachial artery infusion of the B2 receptor-, endothelium-dependent agonist bradykinin and the endothelium-independent agonist sodium nitroprusside in 228 normotensive subjects. In 166 white Americans, systolic blood pressure (SBP) and pulse pressure were highest in the BE1 +9/+9 group (118+/-2 and 51+/-2 mm Hg, respectively; P<0.05 versus -9/-9 for either), intermediate in the +9/-9 group (114+/-1 and 49+/-1 mm Hg, P<0.05 versus -9/-9 for pulse pressure), and lowest in the -9/-9 group (110+/-2 and 44+/-2 mm Hg). In 62 black Americans, FVR was 25% higher in the BE1 +9/+9 group compared with the BE1 +9/-9 and -9/-9 groups at baseline (P=0.038) or during bradykinin (P=0.03). Increased SBP or vascular resistance may contribute to increased left ventricular mass reported previously in individuals with the BE1+9/+9 genotype.
authors.affiliation: Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
authors.forename: M M
authors.initials: MM
authors.lastname: Pretorius
authors.forename: J V
authors.initials: JV
authors.lastname: Gainer
authors.forename: G P
authors.initials: GP
authors.lastname: Van Guilder
authors.forename: E B
authors.initials: EB
authors.lastname: Coelho
authors.forename: J M
authors.initials: JM
authors.lastname: Luther
authors.forename: P
authors.initials: P
authors.lastname: Fong
authors.forename: D D
authors.initials: DD
authors.lastname: Rosenbaum
authors.forename: H A
authors.initials: HA
authors.lastname: Malave
authors.forename: C
authors.initials: C
authors.lastname: Yu
authors.forename: M D
authors.initials: MD
authors.lastname: Ritchie
authors.forename: D E
authors.initials: DE
authors.lastname: Vaughan
authors.forename: N J
authors.initials: NJ
authors.lastname: Brown
mesh_terms: D000328:Adult; D001741:Black or African American / Q000235:genetics*; D001783:Blood Flow Velocity / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects / Q000235:genetics*; D001920:Bradykinin / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D005260:Female; D005542:Forearm / Q000098:blood supply*; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007261:Infusions, Intra-Arterial; D008297:Male; D009599:Nitroprusside / Q000008:administration & dosage; D010641:Phenotype; D011110:Polymorphism, Genetic; D043782:Receptor, Bradykinin B2 / Q000819:agonists / Q000235:genetics*; D012039:Regional Blood Flow / Q000235:genetics; D014655:Vascular Resistance / Q000187:drug effects / Q000235:genetics*; D014665:Vasodilator Agents / Q000008:administration & dosage; D044465:White People / Q000235:genetics*
chemical_list: D043782:Receptor, Bradykinin B2; D014665:Vasodilator Agents; D009599:Nitroprusside; D001920:Bradykinin