title: Human-hemato-lymphoid-system mice: opportunities and challenges.
abstract: With the recent advances in human-hemato-lymphoid-system mice, this commentary discusses the utility of these mice and further improvements required to generate an accessible system that allows predictive in vivo human hematology and immunology research.
authors.affiliation: Institute for Research in Biomedicine (IRB), Via Vincenzo Vela 6, CH-6500 Bellinzona, Switzerland. manz@irb.unisi.ch
authors.forename: Markus G
authors.initials: MG
authors.lastname: Manz
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D003429:Cross Reactions / Q000276:immunology; D006413:Hematopoietic System / Q000166:cytology / Q000276:immunology*; D006801:Humans; D008214:Lymphocytes / Q000166:cytology / Q000276:immunology*; D051379:Mice