title: Inositol pyrophosphates get the vip1 treatment.
abstract: Inositol pyrophosphates are unique signaling molecules implicated in the regulation of diverse cellular processes. Two new studies by Mulugu et al. (2007) and Lee et al. (2007) extend the biological and metabolic diversity of this class of molecules. They identify yeast Vip1 as a new inositol pyrophosphate synthase and show that the products of Vip1 activity regulate a cyclin/cyclin-dependent kinase complex.
authors.affiliation: Medical Research Council (MRC) Cell Biology Unit and Laboratory for Molecular Cell Biology, Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT, UK.
authors.forename: Sara Maria Nancy
authors.initials: SM
authors.lastname: Onnebo
authors.forename: Adolfo
authors.initials: A
authors.lastname: Saiardi
mesh_terms: D018797:Cell Cycle Proteins / Q000378:metabolism*; D018844:Cyclin-Dependent Kinases / Q000378:metabolism; D016213:Cyclins / Q000378:metabolism; D003598:Cytoskeletal Proteins / Q000378:metabolism; D015966:Gene Expression Regulation, Fungal / Q000235:genetics; D007295:Inositol Phosphates / Q000096:biosynthesis* / Q000737:chemistry; D015394:Molecular Structure; D064251:Multifunctional Enzymes; D017856:Phosphotransferases (Phosphate Group Acceptor) / Q000737:chemistry / Q000378:metabolism*; D011755:Pyrophosphatases; D029702:Schizosaccharomyces pombe Proteins / Q000378:metabolism; D015003:Yeasts / Q000235:genetics / Q000378:metabolism*
chemical_list: C121265:Asp1 protein, S pombe; D018797:Cell Cycle Proteins; D016213:Cyclins; D003598:Cytoskeletal Proteins; D007295:Inositol Phosphates; D064251:Multifunctional Enzymes; D029702:Schizosaccharomyces pombe Proteins; D018844:Cyclin-Dependent Kinases; D017856:Phosphotransferases (Phosphate Group Acceptor); C099438:inositol hexakisphosphate kinase; D011755:Pyrophosphatases