Chemically modified solid-state nanopores.
Nanopores are extremely sensitive single-molecule sensors. Recently, electron beams have been used to fabricate synthetic nanopores in thin solid-state membranes with subnanometer resolution. Here we report a new class of chemically modified nanopore sensors. We describe two approaches for monolayer coating of nanopores: (1) self-assembly from solution, in which nanopores approximately 10 nm diameter can be reproducibly coated, and (2) self-assembly under voltage-driven electrolyte flow, in which we are able to coat 5 nm nanopores. We present an extensive characterization of coated nanopores, their stability, reactivity, and pH response.
Wanunu
Meni
M
Department of Biomedical Engineering, Boston University, Boston, Massachusetts 02215, USA.
Meller
Amit
A
D003460:Crystallization / Q000379:methods*; D046911:Macromolecular Substances / Q000737:chemistry; D008422:Materials Testing; D008968:Molecular Conformation; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure*; D036103:Nanotechnology / Q000379:methods*; D010316:Particle Size; D010539:Permeability; D016062:Porosity; D017655:Silicon Compounds / Q000737:chemistry*; D013499:Surface Properties; D014462:Ultrafiltration / Q000379:methods*
D046911:Macromolecular Substances; D017655:Silicon Compounds; C032734:silicon nitride