title: Randomised clinical trial of a laxative alone versus a laxative and a bulking agent after primary repair of obstetric anal sphincter injury.
abstract: OBJECTIVE
  To compare two postpartum laxative regimens in women who have undergone primary repair of obstetric anal sphincter injury.
  
  
  METHODS
  Randomised controlled trial.
  
  
  METHODS
  National Maternity Hospital, Dublin.
  
  
  METHODS
  A total of 147 postpartum women who had sustained anal sphincter injury at vaginal birth.
  
  
  METHODS
  Women were randomised to receive either lactulose alone thrice daily for the first three postpartum days followed by sufficient lactulose to maintain a soft stool over the following 10 days (lactulose group, n = 77) or the lactulose regimen combined with a sachet of ispaghula husk daily for the first 10 postpartum days (Fybogel group, n = 70). All patients kept a diary of bowel habit for the first 10 postpartum days and were invited to return for review at 3 months postpartum.
  
  
  METHODS
  Patient discomfort with first postpartum bowel motion, incidence of postnatal constipation and incontinence and incontinence score in postnatal period.
  
  
  RESULTS
  Pain scores were similar in the two treatment groups; but incontinence in the immediate postnatal period was more frequent with the two preparations compared with lactulose alone (32.86% versus 18.18%, P = 0.03).
  
  
  CONCLUSIONS
  This study does not support routine prescribing of a stool-bulking agent in addition to a laxative in the immediate postnatal period for women who have sustained anal sphincter injury at vaginal delivery.
authors.affiliation: UCD School of Medicine and Medical Science, Dublin, Ireland.
authors.forename: M
authors.initials: M
authors.lastname: Eogan
authors.forename: L
authors.initials: L
authors.lastname: Daly
authors.forename: M
authors.initials: M
authors.lastname: Behan
authors.forename: P R
authors.initials: PR
authors.lastname: O'Connell
authors.forename: C
authors.initials: C
authors.lastname: O'Herlihy
mesh_terms: D000328:Adult; D001003:Anal Canal / Q000293:injuries* / Q000601:surgery; D002400:Cathartics / Q000627:therapeutic use*; D019343:Citric Acid / Q000627:therapeutic use*; D003248:Constipation / Q000188:drug therapy; D004338:Drug Combinations; D004359:Drug Therapy, Combination; D005260:Female; D005765:Gastrointestinal Agents / Q000627:therapeutic use*; D006801:Humans; D007792:Lactulose / Q000627:therapeutic use*; D007744:Obstetric Labor Complications / Q000601:surgery*; D010936:Plant Extracts / Q000627:therapeutic use*; D011247:Pregnancy; D011644:Puerperal Disorders / Q000517:prevention & control; D017693:Sodium Bicarbonate / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D002400:Cathartics; D004338:Drug Combinations; D005765:Gastrointestinal Agents; D010936:Plant Extracts; D019343:Citric Acid; D007792:Lactulose; C018299:citric acid, ispaghula husk, sodium bicarbonate drug combination; D017693:Sodium Bicarbonate