title: RTX toxin actin cross-linking activity in clinical and environmental isolates of Vibrio cholerae.
abstract: Vibrio cholerae strains from diverse O-antigen groups were evaluated for RTX toxin actin cross-linking activity. This study demonstrates that the actin cross-linking domain sequence is present within rtxA in the majority of clinical and environmental isolates tested, and the RTX toxin produced by these strains catalyzes the covalent cross-linking of cellular actin.
authors.affiliation: Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, 303 E. Chicago Ave., Tarry 3-713, Chicago, IL 60611, USA.
authors.forename: Christina L
authors.initials: CL
authors.lastname: Cordero
authors.forename: Shanmuga
authors.initials: S
authors.lastname: Sozhamannan
authors.forename: Karla J Fullner
authors.initials: KJ
authors.lastname: Satchell
mesh_terms: D000199:Actins / Q000378:metabolism*; D000942:Antigens, Bacterial / Q000235:genetics; D001427:Bacterial Toxins / Q000302:isolation & purification* / Q000494:pharmacology*; D002771:Cholera / Q000382:microbiology*; D004777:Environment; D006801:Humans; D014734:Vibrio cholerae / Q000235:genetics / Q000302:isolation & purification* / Q000378:metabolism*
chemical_list: D000199:Actins; D000942:Antigens, Bacterial; D001427:Bacterial Toxins