The risk of developing cervical cancer in Mexican women is associated to CYP1A1 MspI polymorphism.
The aim of the study was to evaluate the association of two CYP1A1 polymorphisms (Msp1 and exon 7) with cervical cancer in Mexican women considering their smoking habit. The polymorphisms were determined in 310 individuals (155 with cervical cancer and 155 healthy controls). Women with MspI T/C or C/C showed increased risk of developing cervical cancer (3.7- and 8.3-fold increase, respectively) compared to women with T/T genotype. When smoking habit was considered, the risk for non-smokers with T/C and C/C genotypes was similar (5.2 and 4.1, respectively), whereas smoking women with C/C genotype showed a 19.4-fold increase of cervical cancer. Number of child births, number of sexual partners and marital status were strong risk factors for developing cervical cancer in women with T/T genotype; however, in women with T/C genotype, only the number of child births and sexual partners had a significant influence. These results suggest an important role of the CYP1A1 MspI polymorphism in the risk of developing cervical cancer.
Juárez-Cedillo
Teresa
T
Epidemiological Research and Health Services Unit, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico.
Vallejo
Maite
M
Fragoso
José Manuel
JM
Hernández-Hernández
Dulce Maria
DM
Rodríguez-Pérez
José Manuel
JM
Sánchez-García
Sergio
S
del Carmen García-Peña
María
M
García-Carrancá
Alejandro
A
Mohar-Betancourt
Alejandro
A
Granados
Julio
J
Vargas-Alarcón
Gilberto
G
D000328:Adult; D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics*; D005091:Exons; D005260:Female; D006801:Humans; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D030361:Papillomavirus Infections / Q000175:diagnosis; D011110:Polymorphism, Genetic / Q000235:genetics*; D018570:Risk Assessment; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology / Q000208:ethnology / Q000235:genetics*
D019363:Cytochrome P-450 CYP1A1