title: Enzyme inhibition activities of Andrachne cardifolia Muell.
abstract: The crude methanolic extract and various fractions of Andrachne cardifolia Muell, including chloroform, ethyl acetate and n-butanol fractions were subjected to in vitro enzyme inhibition activity against acetylcholinesterase, butyrylcholinesterase, lipoxygenase and urease enzymes. A significant enzyme inhibition activity (40-89%) was shown by the crude methanolic extract and its fractions against lipoxygenase, while low to significant activity (40-71%) against butyrylcholinesterase. The crude methanolic extract and its various fractions demonstrated poor to significant activity (25-73%) against acetylcholinesterase and no activity against urease.
authors.affiliation: Department of Pharmacy, University of Peshawar, Peshawar, Pakistan. bashirdr2001@yahoo.com
authors.forename: Bashir
authors.initials: B
authors.lastname: Ahmad
authors.forename: S M Hassan
authors.initials: SM
authors.lastname: Shah
authors.forename: Shumaila
authors.initials: S
authors.lastname: Bashir
authors.forename: Jehandar
authors.initials: J
authors.lastname: Shah
mesh_terms: D020001:1-Butanol / Q000737:chemistry; D000085:Acetates / Q000737:chemistry; D002725:Chloroform / Q000737:chemistry; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D019665:Euphorbiaceae / Q000737:chemistry*; D000432:Methanol / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000085:Acetates; D004791:Enzyme Inhibitors; D010936:Plant Extracts; C007650:ethyl acetate; D002725:Chloroform; D020001:1-Butanol; D000432:Methanol