title: Frontal-lobe syndrome and psychosis after damage to the brainstem dopaminergic nuclei.
abstract: A patient developed frontal-lobe syndrome and psychotic symptoms after infarction in the pontomesencephalic junction. Stereotaxic lesion localization on magnetic resonance imaging and statistical analyses of regional cerebral blood flow (rCBF) disclosed an involvement of the rostral brainstem dopaminergic nuclei and hypoperfusion in the frontal-subcortical circuit components. We suggest that the patient's cognitive and behavioral disturbances were associated with disruption of ascending dopaminergic projections to the frontal-subcortical circuits.
authors.affiliation: Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Sendai, Japan. nishiou@mail.tains.tohoku.ac.jp
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Nishio
authors.forename: Kazunari
authors.initials: K
authors.lastname: Ishii
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Kazui
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Hosokai
authors.forename: Etsuro
authors.initials: E
authors.lastname: Mori
mesh_terms: D000368:Aged; D001931:Brain Mapping; D001933:Brain Stem / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology*; D020526:Brain Stem Infarctions / Q000150:complications / Q000503:physiopathology; D002560:Cerebrovascular Circulation / Q000502:physiology; D003704:Dementia / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology*; D004298:Dopamine / Q000378:metabolism*; D005260:Female; D005625:Frontal Lobe / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D009434:Neural Pathways / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology*; D011149:Pons / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology; D011618:Psychotic Disorders / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology*; D013681:Tegmentum Mesencephali / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D004298:Dopamine