title: Calcium and phosphorus metabolism disturbances after renal transplantation.
abstract: BACKGROUND
  Several studies have noted that, despite beneficial correction of abnormalities of mineral metabolism after successful renal transplantation, renal functional recovery is incomplete. Also, persistence of hyperparathyroidism and metabolic acidosis among patients with chronic impairment of graft function together with the use of loop diuretics and immunosuppressive drugs with adverse effects may alter mineral metabolism. We determined calcium and phosphorus levels in recipients.
  
  
  METHODS
  This cross-sectional study enrolled 398 recipients in 2 medical centers in Iran from 1988 to 2004 to evaluate serum calcium and phosphorus levels after 1 month in relation to graft and patient survivals. Cyclosporine was the constant part of the immunosuppressive treatment in all study subjects.
  
  
  RESULTS
  The median follow-up time was 8 months (range, 1-180 months). One and 10-year survival rates of patients were 97.9% and 91.1%. Mean (SD) serum calcium levels before and after transplantation were 8.79 (1.26) and 8.50 (1.39) mg/dL, respectively (P=.020). The mean (SD) phosphate levels before and after transplantation were 6.43 (2.42) and 3.64 (1.71) mg/dL, respectively (P=.000). There was no significant difference in survival considering changes in serum calcium and phosphorus levels. There was no correlation between serum calcium and phosphorus level changes among study patients.
  
  
  CONCLUSIONS
  Despite reports suggesting hypercalcemia as a posttransplantation finding, we did not observe this condition, but, consistent with other reports in this field, we observed a significant decrease in serum phosphorus levels showing correction of this mineral level.
authors.affiliation: Department of Internal Medicine, Baqyiatollah University of Medical Sciences, Tehran, Iran.
authors.forename: M
authors.initials: M
authors.lastname: Ramezani
authors.forename: B
authors.initials: B
authors.lastname: Einollahi
authors.forename: M A
authors.initials: MA
authors.lastname: Asl
authors.forename: M
authors.initials: M
authors.lastname: Nafar
authors.forename: V
authors.initials: V
authors.lastname: Pourfarziani
authors.forename: M
authors.initials: M
authors.lastname: Moradi
authors.forename: A
authors.initials: A
authors.lastname: Samadpour
authors.forename: M
authors.initials: M
authors.lastname: Alghasi
authors.forename: F
authors.initials: F
authors.lastname: Davoudi
mesh_terms: D002118:Calcium / Q000378:metabolism*; D005260:Female; D006085:Graft Survival; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000601:surgery; D016030:Kidney Transplantation / Q000009:adverse effects* / Q000401:mortality; D008297:Male; D008659:Metabolic Diseases / Q000453:epidemiology*; D008875:Middle Aged; D010758:Phosphorus / Q000378:metabolism*; D012189:Retrospective Studies; D016019:Survival Analysis
chemical_list: D010758:Phosphorus; D002118:Calcium