Hypoxia and the lung: beyond hypoxic vasoconstriction.
This article extends the influence and effects of hypoxia on the lung beyond vasoconstriction and regional blood flow control. Clearly, hypoxia, via the transcription factor hypoxia-inducible factor (HIF)-1alpha, induces a large number of genes encoding proteins, which control cellular metabolism and growth and also participate in inflammation. Hypoxia, likely via vascular endothelial growth factor (VEGF), recruits bone marrow precursor cells to the lung and affects the behavior of immune cells. How hypoxia shapes immune responses through VEGF and its receptors on mast cells, eosinophils, and dendritic cells and through lung endothelial cell/lymphocyte interactions will be a productive area for future research.
Nicolls
Mark R
MR
Pulmonary Hypertension Center and Division of Pulmonary and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA. norbert.voelkel@uchsc.edu
Voelkel
Norbert F
NF
D000818:Animals; D006801:Humans; D000860:Hypoxia / Q000276:immunology / Q000473:pathology*; D008168:Lung / Q000098:blood supply* / Q000276:immunology / Q000473:pathology*; D015398:Signal Transduction / Q000276:immunology; D014661:Vasoconstriction