title: gyrA and parC Mutations and associated quinolone resistance in Vibrio anguillarum serotype O2b strains isolated from farmed Atlantic cod (Gadus morhua) in Norway.
abstract: MIC testing of Vibrio anguillarum isolates recovered from diseased farmed Atlantic cod revealed oxolinic acid MICs of < or =0.001, 0.06, and 16 microg ml(-1). Single gyrA Ser-Ile substitutions were identified at position 83 of the intermediate and resistant strains, while a parC Ser-Leu substitution at position 85 was found only in the resistant strain.
authors.affiliation: National Veterinary Institute, Section for Fish Health, Ullevaalsveien 68, Oslo 0454, Norway. duncan.colquhoun@vetinst.no
authors.forename: D J
authors.initials: DJ
authors.lastname: Colquhoun
authors.forename: L
authors.initials: L
authors.lastname: Aarflot
authors.forename: C F
authors.initials: CF
authors.lastname: Melvold
mesh_terms: D000818:Animals; D001483:Base Sequence; D027081:DNA Gyrase / Q000235:genetics*; D027101:DNA Topoisomerase IV / Q000235:genetics*; D024881:Drug Resistance, Bacterial; D005393:Fish Diseases / Q000382:microbiology; D005398:Fisheries; D048389:Gadus morhua / Q000382:microbiology*; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D009154:Mutation; D009664:Norway / Q000453:epidemiology; D015363:Quinolones / Q000494:pharmacology*; D012703:Serotyping; D014733:Vibrio / Q000145:classification / Q000187:drug effects / Q000201:enzymology / Q000235:genetics* / Q000302:isolation & purification; D014735:Vibrio Infections / Q000188:drug therapy / Q000382:microbiology / Q000662:veterinary
chemical_list: D015363:Quinolones; D027101:DNA Topoisomerase IV; D027081:DNA Gyrase