title: Comprehensive coronary artery disease care in a safety-net hospital: results of Get With The Guidelines quality improvement initiative.
abstract: BACKGROUND
  Adherence to published coronary artery disease (CAD) guidelines is suboptimal, particularly among minorities and the poor. While hospital-based quality-improvement programs may increase the use of evidence-based therapies, little data exist regarding the impact of such programs in sociodemographically disadvantaged (vulnerable) populations. Vulnerable patients in the United States are cared for primarily within the safety-net health system, which comprises urban public hospitals and outpatient community health centers. Denver Health is an example of an integrated system that encompasses both types of facilities.
  
  
  OBJECTIVE
  To assess evidence-based medication use in CAD patients after initiation of an inpatient quality-improvement program at Denver Health.
  
  
  METHODS
  We reviewed the medical records of 499 patients with angiographically proven CAD who were hospitalized between July 1998 and December 2002. Patients were prospectively identified through a multidisciplinary intervention led by a nurse manager, and their records were input retrospectively into the American Heart Association's Get With The Guidelines patient management tool. The association's program, which recommends initiating 4 cardioprotective drug classes while patients are hospitalized, was started 2 years into the observation period (August 2000). Treatment rates were compared over the ensuing years. We evaluated temporal trends in discharge use of 4 drugs: (1) betablockers, (2) angiotensin-converting enzyme inhibitors (ACEIs), (3) hydroxymethylglutaryl coenzyme A reductase inhibitors (statins), and (4) aspirin. We calculated the proportion of eligible patients (no documented contraindication) who were prescribed each drug category as well as the proportion who received all 4 drug categories, our principal composite outcome. If any one drug was absent, the composite criterion was considered unmet.
  
  
  RESULTS
  We observed progressive improvement in discharge use of the 4- drug composite: 18% in 1998-1999 (95% confidence interval [CI], 12%-25%), 50% in 2000 (95% CI, 37%-63%), 62% (95% CI, 54%-70%) in 2001, and 72% (65%-79%) in 2002 (P <0.001 for between-year differences). Among eligible patients discharged in 2002, 90% received beta-blockers, 91% received ACEIs, 86% received statins, and 93% received aspirin.
  
  
  CONCLUSIONS
  Implementation of a multidisciplinary program led by a nurse manager was associated with increased CAD guideline compliance among sociodemographically disadvantaged patients. This compliance exceeded national averages. Achievement of the composite measure of use of all 4 recommended drug categories at discharge improved from 18% in 1998-1999 to 72% in 2002.
authors.affiliation: Cardiac Risk Reduction Program, Denver Health, CO 80204, USA. mkranz@dhha.org
authors.forename: Mori J
authors.initials: MJ
authors.lastname: Krantz
authors.forename: William A
authors.initials: WA
authors.lastname: Baker
authors.forename: Raymond O
authors.initials: RO
authors.lastname: Estacio
authors.forename: Deborah K
authors.initials: DK
authors.lastname: Haynes
authors.forename: Philip S
authors.initials: PS
authors.lastname: Mehler
authors.forename: Gregg C
authors.initials: GC
authors.lastname: Fonarow
authors.forename: Carlin S
authors.initials: CS
authors.lastname: Long
mesh_terms: D000328:Adult; D000368:Aged; D002318:Cardiovascular Diseases / Q000188:drug therapy*; D003120:Colorado; D019317:Evidence-Based Medicine; D005260:Female; D019983:Guideline Adherence; D006761:Hospitals; D006801:Humans; D008297:Male; D008485:Medical Audit; D008875:Middle Aged; D010351:Patient Discharge; D011203:Poverty; D011785:Quality Assurance, Health Care