title: Neural logic molecular, counter-intuitive.
abstract: A hypothesis is proposed that multiple "LOGIC" genes control Boolean logic in a neuron. Each hypothetical LOGIC gene encodes a transcription factor that regulates another LOGIC gene(s). Through transcription regulation, LOGIC genes connect into a complex circuit, such as a XOR logic gate or a two-input flip-flop logic circuit capable of retaining information. LOGIC gene duplication, mutation and recombination may result in the diversification of Boolean logic gates. Creative thinking may sometimes require counter-intuitive reasoning, rather than common sense. Such reasoning is likely to engage novel logic circuits produced by LOGIC somatic mutations. An individual's logic maturates by a mechanism of somatic hypermutation, gene conversion and recombination of LOGIC genes in precursor cells followed by selection of neurons in the brain for functional competence. In this model, a single neuron among billions in the brain may contain a unique logic circuit being the key to a hard intellectual problem. The output of a logic neuron is likely to be a neurotransmitter. This neuron is connected to other neurons in the spiking neural network. The LOGIC gene hypothesis is testable by molecular techniques. Understanding mechanisms of authentic human ingenuity may help to invent digital systems capable of creative thinking.
authors.affiliation: The Jackson Laboratory, Bar Harbor, ME 04609-1500, USA. ike@jax.org
authors.forename: Igor K
authors.initials: IK
authors.lastname: Egorov
mesh_terms: D003198:Computer Simulation; D039301:Computers, Molecular; D005786:Gene Expression Regulation / Q000502:physiology*; D016015:Logistic Models; D008959:Models, Neurological; D009474:Neurons / Q000502:physiology*; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D014157:Transcription Factors