Susceptibility of cyprinid cultured cells to cyprinid herpesvirus 3.
Cyprinid herpesvirus 3 is a highly contagious and lethal virus that affects ornamental koi and common carp worldwide. However, it is not yet known whether other cyprinids are infected and/or harbor the virus. Here, we report that cultured cells derived from common carp, koi, silver carp and goldfish allow CyHV-3 propagation, while cyprinid cells derived from fathead minnow and non-cyprinid cells derived from the channel catfish ovary are resistant to CyHV-3 infection. Interestingly, the epithelioma papulosum Cyprini cells derived from Cyprinus carpio are restrictive to the virus. These results indicate that CyHV-3 is not restricted to common carp and koi, but other cyprinids are also vulnerable to the virus.
Davidovich
M
M
Department of Pathology, The Hebrew University-Hadassah Medical School, Jerusalem, Israel.
Dishon
A
A
Ilouze
M
M
Kotler
M
M
D000818:Animals; D002347:Carps / Q000821:virology*; D002478:Cells, Cultured; D003588:Cytopathogenic Effect, Viral; D004261:DNA Replication; D006054:Goldfish / Q000821:virology*; D006564:Herpesviridae / Q000235:genetics / Q000472:pathogenicity* / Q000502:physiology; D016133:Polymerase Chain Reaction; D014764:Viral Proteins / Q000235:genetics / Q000378:metabolism; D014779:Virus Replication
D014764:Viral Proteins