Involvement of Y(5) receptors in neuropeptide Y agonist-induced analgesic-like effect in the rat hot plate test.
Neuropeptide Y (NPY) induces analgesic-like effects after central administration across diverse pain models in rodents. In spinal pain models, previous studies indicate a prominent role for Y(1) receptors at mediating this effect of NPY. In supraspinal pain models like the hot plate test, the NPY receptors involved have not been thoroughly explored. By intracerebroventricular (i.c.v.) administration of selective NPY receptor ligands, the possible involvement of Y(5) receptors in analgesic-like mechanisms was investigated using the hot plate test in rats. Both NPY and selective Y(5) agonists induced analgesic-like effects as revealed by prolonged hot plate latencies. Further consistent with a role for Y(5) receptors, pretreatment with a selective Y(5) receptor antagonist blocked the Y(5) agonist-induced analgesic-like effect. The present study indicates involvement of Y(5) receptors probably at the supraspinal level in mediation of NPY agonist-induced analgesic-like effects in the hot plate test.
Thomsen
Morgane
M
Laboratory of Neuropsychiatry, Rigshospitalet University Hospital O-6102 and Department of Neuroscience and Pharmacology, University of Copenhagen, 9 Blegdamsvej, Copenhagen, Denmark.
Wörtwein
Gitta
G
Olesen
Mikkel V
MV
Begtrup
Mikael
M
Havez
Sophie
S
Bolwig
Tom G
TG
Woldbye
David P D
DP
D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D004195:Disease Models, Animal; D006358:Hot Temperature; D007276:Injections, Intraventricular; D009478:Neuropeptide Y / Q000008:administration & dosage / Q000494:pharmacology*; D010146:Pain / Q000503:physiopathology / Q000517:prevention & control*; D010446:Peptide Fragments / Q000494:pharmacology; D051381:Rats; D017476:Receptors, Neuropeptide Y / Q000037:antagonists & inhibitors*
D000700:Analgesics; D009478:Neuropeptide Y; D010446:Peptide Fragments; D017476:Receptors, Neuropeptide Y