Hodgkin's lymphoma in a patient with Jo-1 syndrome.
Jo-1 syndrome is an autoimmune disease with autoantibodies against the histidyl tRNA synthetase. Characteristic clinical findings include inflammatory myopathy and interstitial lung disease. We present the first case of a patient with Jo-1 syndrome (positive Jo-1 autoantibodies, myositis, interstitial alveolitis) who developed Hodgkin's lymphoma of nodular-sclerosing type. Thus, patients with Jo-1 syndrome and immunosuppressive therapy similar to other patients with autoimmune disease are at risk to develop lymphomas and should therefore be monitored carefully.
Adam
Alexander C
AC
Department of Pathology, University of Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany. alexander.adam@ukb.uni-bonn.de
Grohé
Christian
C
Stier
Sebastian
S
Gattenlöhner
Stefan
S
Balta
Zeynep
Z
Büttner
Reinhard
R
Gütgemann
Ines
I
D000974:Antibodies, Antinuclear / Q000097:blood*; D000914:Antibodies, Viral / Q000097:blood; D006689:Hodgkin Disease / Q000209:etiology*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009220:Myositis / Q000150:complications*; D011658:Pulmonary Fibrosis / Q000150:complications*; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000235:genetics; D013577:Syndrome
D000974:Antibodies, Antinuclear; D000914:Antibodies, Viral; C046750:Jo-1 antibody; D016692:Receptors, Antigen, T-Cell, gamma-delta