Immunohistochemical expression of cyclooxygenase-2 in canine ovarian carcinomas.
Ovarian tumours among domestic animals are frequently encountered in bitch. Cyclooxygenase-2 (COX-2) expression has been evaluated in different kind of canine primary epithelial neoplasms. Eleven canine ovarian carcinomas and two normal samples were evaluated immunohistochemically for COX-2 expression. Nine of 11 carcinoma samples (81%) expressed COX-2 enzyme isoform. The immunoreactivity was intracytoplasmically recorded and the intensity ranged from faint to strong. Our results show that COX-2 is expressed in canine ovarian carcinoma, suggesting a potential role of COX-2 in canine ovarian carcinogenesis.
Borzacchiello
G
G
Department of Pathology and Animal Health, General Pathology and Anatomic Pathology Division, Faculty of Veterinary Medicine, University of Naples Federico II Via F. Delpino, 1-80137 Naples, Italy. borzacch@unina.it
Russo
V
V
Russo
M
M
D000818:Animals; D002277:Carcinoma / Q000201:enzymology / Q000473:pathology / Q000662:veterinary*; D051546:Cyclooxygenase 2 / Q000096:biosynthesis* / Q000378:metabolism; D004283:Dog Diseases / Q000201:enzymology* / Q000473:pathology; D004285:Dogs; D005260:Female; D007150:Immunohistochemistry / Q000379:methods / Q000662:veterinary; D010051:Ovarian Neoplasms / Q000201:enzymology / Q000473:pathology / Q000662:veterinary*
D051546:Cyclooxygenase 2