[Anti-infectious defense of vagina during use of low-dose monophasic contraceptives].
Increase in incidence of candidal colpitis has been observed during use of contraceptive drugs. Elimination of staphylococci from genital tract after use of contraceptives was detected in 34,7% of patients. Composition of other aerobic microflora did not change. Nonspecific immune reaction was characterized by intensified phagocytosis, increase of results of NBT reduction test and level of proinflammatory cytokines. Conclusion about inappropriateness of using low-dose oral contraceptives in patients with recurrent vulvovaginal candidosis was made. Such contraceptives can be recommended to women with prolonged inflammatory diseases of reproductive system.
Lebedeva
O P
OP
Kalutskiĭ
P V
PV
D002175:Candida / Q000302:isolation & purification; D002177:Candidiasis / Q000139:chemically induced / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control; D003278:Contraceptives, Oral, Hormonal / Q000008:administration & dosage / Q000009:adverse effects*; D016207:Cytokines / Q000096:biosynthesis; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000302:isolation & purification; D007071:Immunoglobulin A, Secretory / Q000302:isolation & purification; D007074:Immunoglobulin G / Q000302:isolation & purification; D009195:Peroxidase / Q000378:metabolism; D010587:Phagocytosis; D013203:Staphylococcal Infections / Q000188:drug therapy; D013210:Staphylococcus / Q000302:isolation & purification; D014621:Vagina / Q000276:immunology / Q000382:microbiology; D014627:Vaginitis / Q000139:chemically induced / Q000276:immunology* / Q000382:microbiology* / Q000517:prevention & control
D003278:Contraceptives, Oral, Hormonal; D016207:Cytokines; D007070:Immunoglobulin A; D007071:Immunoglobulin A, Secretory; D007074:Immunoglobulin G; D009195:Peroxidase