title: A new approach using tissue alkaline phosphatase histochemistry to identify Crohn's disease.
abstract: In the present study, we investigate intestinal alkaline phosphatase activity in mucosal biopsies in patients with inflammatory bowel disease. Crohn's disease influences the alkaline phosphatase activity in the intestine, increasing its activity. We present a histochemistry-based method for alkaline phosphatase that is useful for the identification of Crohn's disease and the differentiation of ulcerative colitis.
authors.affiliation: Department of Experimental Biology, Faculty of Sciences, University of Jaén, Paraje de las Lagunillas s/n 23071, Jaén, Spain. mitorres@ujaen.es
authors.forename: M I
authors.initials: MI
authors.lastname: Torres
authors.forename: P
authors.initials: P
authors.lastname: Lorite
authors.forename: M A
authors.initials: MA
authors.lastname: López-Casado
authors.forename: A
authors.initials: A
authors.lastname: Ríos
mesh_terms: D000469:Alkaline Phosphatase; D000951:Antigens, Neoplasm / Q000032:analysis*; D003093:Colitis, Ulcerative / Q000175:diagnosis* / Q000201:enzymology / Q000473:pathology; D003424:Crohn Disease / Q000175:diagnosis* / Q000201:enzymology / Q000473:pathology; D003937:Diagnosis, Differential; D058851:GPI-Linked Proteins; D006651:Histocytochemistry / Q000379:methods*; D006801:Humans; D007413:Intestinal Mucosa / Q000201:enzymology* / Q000473:pathology; D011237:Predictive Value of Tests
chemical_list: D000951:Antigens, Neoplasm; D058851:GPI-Linked Proteins; C063088:ALPI protein, human; D000469:Alkaline Phosphatase