title: Ultrasound screening for fetal major abnormalities at 11-14 weeks.
abstract: BACKGROUND
  This study was planned to evaluate the efficiency of the 11-14 week scan in detecting fetuses with major fetal structural abnormalities.
  
  
  METHODS
  Some 1,290 pregnant women were submitted to a routine ultrasound scan between the 11th and 14th week after the detection of the fetal viability. The fetal anatomy was examined transabdominally, and in suspected cases transvaginally. Following the scans, the patients were examined in the second or third trimester of pregnancy. Fetal structural abnormalities classified as major and early onset were noted. Isolated choroid plexus cysts, cardiac defects not requiring treatment, mild ventriculomegaly, and mild renal pelviectasis in second trimester were not included.
  
  
  RESULTS
  Twenty-four (1.86%) fetuses with various defects were identified, and 17 of these were diagnosed at the 11-14 week scan. The antenatal ultrasound detection rate of the fetuses with major anomalies was 95%, and 70% were detected in the first-trimester assessment. Four cardiac defects associated with genetic syndromes or requiring operation were included (0.31%) in this series. Two of the fetuses with cardiac defects (50%) had an increased nuchal translucency thickness. In this group, none of the fetuses with karyotype anomalies was born alive.
  
  
  CONCLUSIONS
  The first-trimester scan is important in routine antenatal care for early detection of fetal defects, and determination of the fetuses at risk of cardiac anomalies and genetic syndromes.
authors.affiliation: Department of Gynecology and Obstetrics, Division of Perinatology, Haseki Training and Research Hospital, Istanbul, Turkey.
authors.forename: Banu
authors.initials: B
authors.lastname: Dane
authors.forename: Cem
authors.initials: C
authors.lastname: Dane
authors.forename: Derya
authors.initials: D
authors.lastname: Sivri
authors.forename: Murat
authors.initials: M
authors.lastname: Kiray
authors.forename: Ahmet
authors.initials: A
authors.lastname: Cetin
authors.forename: Murat
authors.initials: M
authors.lastname: Yayla
mesh_terms: D000293:Adolescent; D000328:Adult; D000013:Congenital Abnormalities / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008875:Middle Aged; D048208:Nuchal Translucency Measurement; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D016216:Ultrasonography, Prenatal / Q000379:methods* / Q000639:trends