[Measurement of sphingosine 1-phosphate as a biomarker of atherosclerosis].
Sphingosine 1-phosphate (S1P) is concentrated in lipoprotein, especially high density lipoprotein (HDL), in plasma. We characterized the role of HDL-associated S1P in HDL-induced anti-atherogenic effects. HDL-associated S1P mediated HDL-induced stimulation of proliferation, migration and inhibition of apoptosis through S1P specific receptors S1P1 and/or S1P3 in endothelial cells. On the other hand, HDL-induced nitric oxide production and inhibition of adhesion molecule expression were mediated by two pathways, i.e, HDL-associated apoprotein A-I, A-II/SR-BI and S1P/S1P receptors in endothelial cells. Thus, in endothelial cells, HDL-associated S1P is a key player of HDL-induced anti-atherogenic effects.
Kimura
Takao
T
Department of Clinical Laboratory Center, Gunma University Hospital, Maebashi 371-8511.
Okajima
Fumikazu
F
Murakami
Masami
M
D050197:Atherosclerosis / Q000097:blood*; D015415:Biomarkers / Q000097:blood*; D042783:Endothelial Cells / Q000502:physiology; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood*; D008246:Lysophospholipids / Q000097:blood*; D049349:Receptors, Lysosphingolipid / Q000502:physiology; D013110:Sphingosine / Q000031:analogs & derivatives* / Q000097:blood
D015415:Biomarkers; D008075:Lipoproteins, HDL; D008246:Lysophospholipids; D049349:Receptors, Lysosphingolipid; C060506:sphingosine 1-phosphate; D013110:Sphingosine