Phloroglucinol derivatives guttiferone G, aristoforin, and hyperforin: inhibitors of human sirtuins SIRT1 and SIRT2.
Gey
Claudia
C
Institut für Organische Chemie, Universität Leipzig, Johannisallee 29, 04103 Leipzig, Germany.
Kyrylenko
Sergiy
S
Hennig
Lothar
L
Nguyen
Lien-Hoa D
LH
Büttner
Anita
A
Pham
Hung D
HD
Giannis
Athanassios
A
D001643:Bridged Bicyclo Compounds / Q000737:chemistry* / Q000633:toxicity; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010696:Phloroglucinol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000633:toxicity; D056564:Sirtuin 1; D056565:Sirtuin 2; D037761:Sirtuins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D013729:Terpenes / Q000737:chemistry* / Q000633:toxicity
C502222:Aristoforin; D001643:Bridged Bicyclo Compounds; D013729:Terpenes; C522524:guttiferone G; D010696:Phloroglucinol; C447939:SIRT1 protein, human; C474199:SIRT2 protein, human; D056564:Sirtuin 1; D056565:Sirtuin 2; D037761:Sirtuins; C001654:hyperforin