Filaggrin's fuller figure: a glimpse into the genetic architecture of atopic dermatitis.
Prevalent mutations in the FLG gene underlie the common skin disorder ichthyosis vulgaris and are significant risk factors for atopic dermatitis (eczema). The recent publication of a strategy to sequence this difficult gene identifies a spectrum of both prevalent and rare mutations that collectively have a significant impact on susceptibility to atopic disease.
Sandilands
Aileen
A
Epithelial Genetics Group, Human Genetics Unit, University of Dundee, Dundee, UK.
Smith
Frances J D
FJ
Irvine
Alan D
AD
McLean
W H Irwin
WH
D003876:Dermatitis, Atopic / Q000453:epidemiology* / Q000235:genetics*; D000091344:Filaggrin Proteins; D020022:Genetic Predisposition to Disease / Q000453:epidemiology; D006801:Humans; D007381:Intermediate Filament Proteins / Q000235:genetics*; D015995:Prevalence; D012307:Risk Factors
C000717249:FLG protein, human; D000091344:Filaggrin Proteins; D007381:Intermediate Filament Proteins