title: Noncanonical cell death pathways act during Drosophila oogenesis.
abstract: Programmed cell death (PCD) is a highly conserved process that occurs during development and in response to adverse conditions. In Drosophila, most PCDs require the genes within the H99 deficiency, the adaptor molecule Ark, and caspases. Here we investigate 10 cell death genes for their potential roles in two distinct types of PCD that occur in oogenesis: developmental nurse cell PCD and starvation-induced PCD. Most of the genes investigated were found to have little effect on late stage developmental PCD in oogenesis, although ark mutants showed a partial inhibition. Mid-stage starvation-induced germline PCD was found to be independent of the upstream activators and ark although it requires caspases, suggesting an apoptosome-independent mechanism of caspase activation in mid-oogenesis. These results indicate that novel pathways must control PCD in the ovary.
authors.affiliation: Department of Biology, Boston University, Boston, Massachusetts 02115, USA.
authors.forename: Jeanne S
authors.initials: JS
authors.lastname: Peterson
authors.forename: B Paige
authors.initials: BP
authors.lastname: Bass
authors.forename: Deborah
authors.initials: D
authors.lastname: Jue
authors.forename: Antony
authors.initials: A
authors.lastname: Rodriguez
authors.forename: John M
authors.initials: JM
authors.lastname: Abrams
authors.forename: Kimberly
authors.initials: K
authors.lastname: McCall
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000235:genetics*; D053478:Apoptosomes / Q000235:genetics*; D004330:Drosophila / Q000235:genetics / Q000254:growth & development*; D029721:Drosophila Proteins / Q000235:genetics / Q000502:physiology*; D005260:Female; D017344:Genes, Insect / Q000502:physiology; D009154:Mutation; D009866:Oogenesis; D015398:Signal Transduction
chemical_list: D053478:Apoptosomes; D029721:Drosophila Proteins