title: The biology and chemistry of hyperlipidemia.
abstract: Coronary arterial diseases are responsible for more deaths than all other associated causes combined. Elevated serum cholesterol levels leading to atherosclerosis can cause coronary heart disease (CHD). Reduction in serum cholesterol levels reduces the risk for CHD, substantially. Medicinal chemists all around the world have been designing, synthesizing, and evaluating a variety of new bioactive molecules for lowering lipid levels. This review summarizes the disorders associated with elevation of lipids in blood and the current strategies to control them. The emphasis has been laid in particular on the new potential biological targets and the possible treatments as well as the current ongoing research status in the field of lipid lowering agents.
authors.affiliation: Sinhgad College of Pharmacy, S. No. 44/1, Vadgaon(Bk.), Sinhgad Road, Pune 411 041, India. ks_jain@vsnl.net
authors.forename: Kishor S
authors.initials: KS
authors.lastname: Jain
authors.forename: M K
authors.initials: MK
authors.lastname: Kathiravan
authors.forename: Rahul S
authors.initials: RS
authors.lastname: Somani
authors.forename: Chamanlal J
authors.initials: CJ
authors.lastname: Shishoo
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000378:metabolism; D001669:Biochemical Phenomena; D001671:Biochemistry; D018450:Disease Progression; D015195:Drug Design; D006801:Humans; D006949:Hyperlipidemias / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D008074:Lipoproteins / Q000378:metabolism
chemical_list: D008074:Lipoproteins