Antimicrobial studies of 2,4-dichloro-5-fluorophenyl containing oxadiazoles.
A series of 2,4-dichloro-5-fluorophenyl containing 1,3,4-oxadiazoles (10 and 11) were synthesized by POCl3 cyclization of 2,4-dichloro-5-fluorobenzoyl hydrazide (4) and 2-(2,4-dichloro-5-fluorophenyl)cinchoninyl hydrazide (8) with aryloxyacetic acids (9). The structures of newly synthesized compounds were characterized by spectral and elemental analyses. All the compounds were screened for their antibacterial and antifungal activities. Compounds 10a, 10d and 11g showed very good antimicrobial activity. Compound 10d showed good bactericidal and fungicidal activities.
Karthikeyan
Mari Sithambaram
MS
Department of Chemistry, Mangalore University, Mangalagangothri, Mangalore, Karnataka 574199, India. karthims02@rediffmail.com
Prasad
Dasappa Jagadeesh
DJ
Mahalinga
Manjathuru
M
Holla
Bantwal Shivarama
BS
Kumari
Nalilu Suchetha
NS
D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D005658:Fungi / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D010069:Oxadiazoles / Q000737:chemistry* / Q000494:pharmacology*; D013055:Spectrophotometry, Infrared; D013329:Structure-Activity Relationship
D000890:Anti-Infective Agents; D010069:Oxadiazoles