The psychomodulatory action of subpyrogenic doses of interleukin-1beta in conditions of chronic administration to rats.
The effects of interleukin-1beta at low, subpyrogenic doses on behavior were studied in rats. Signs of increased anxiety were evident by day 5 of treatment courses. These results provide evidence supporting the role of proinflammatory cytokines in the pathogenesis of emotional disorders.
Sokolova
E S
ES
State Research Institute of Experimental Medicine, Russian Academy of Medical Sciences, 12 Academician Pavlov Street, 197376, St. Petersburg, Russia. v/ioudyno@mail.ru
Lyudyno
V I
VI
Simbirtsev
A S
AS
Klimenko
V M
VM
D000818:Animals; D001007:Anxiety / Q000139:chemically induced* / Q000276:immunology; D001522:Behavior, Animal / Q000502:physiology*; D004334:Drug Administration Schedule; D005106:Exploratory Behavior / Q000502:physiology*; D005334:Fever / Q000139:chemically induced; D018836:Inflammation Mediators / Q000008:administration & dosage; D053583:Interleukin-1beta / Q000008:administration & dosage / Q000502:physiology*; D008297:Male; D015213:Neuroimmunomodulation / Q000276:immunology / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar
D018836:Inflammation Mediators; D053583:Interleukin-1beta