title: Phonetic mismatch negativity predicts social skills acquisition in schizophrenia.
abstract: Neurobiological mechanisms for social skills acquisition in schizophrenia remain largely unknown. We investigated whether an electrophysiological index of cognitive function predicts the degree of training-related social skills improvement in schizophrenia. Thirteen patients with schizophrenia underwent assessment of mismatch negativity (MMN) event-related potentials, followed by participation in a 3-month social skills training. Larger right frontal/temporal MMN current density values elicited by across-phoneme change were significantly associated with individual degrees of improvement in total social skills scores as assessed by a structured role play test. Although preliminary, these results suggest that phonetic MMN could be an index of social skills acquisition in patients with schizophrenia.
authors.affiliation: Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. yukik-tky@umin.ac.jp
authors.forename: Yuki
authors.initials: Y
authors.lastname: Kawakubo
authors.forename: Satoru
authors.initials: S
authors.lastname: Kamio
authors.forename: Takahiko
authors.initials: T
authors.lastname: Nose
authors.forename: Akira
authors.initials: A
authors.lastname: Iwanami
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Nakagome
authors.forename: Masato
authors.initials: M
authors.lastname: Fukuda
authors.forename: Nobumasa
authors.initials: N
authors.lastname: Kato
authors.forename: Mark A
authors.initials: MA
authors.lastname: Rogers
authors.forename: Kiyoto
authors.initials: K
authors.lastname: Kasai
mesh_terms: D000328:Adult; D003072:Cognition Disorders / Q000175:diagnosis / Q000453:epidemiology; D004569:Electroencephalography; D005071:Evoked Potentials / Q000502:physiology; D005260:Female; D005625:Frontal Lobe / Q000502:physiology; D006801:Humans; D007858:Learning; D008297:Male; D010700:Phonetics; D012559:Schizophrenia / Q000453:epidemiology*; D012565:Schizophrenic Psychology; D012919:Social Behavior; D012938:Social Perception; D013067:Speech Perception; D011795:Surveys and Questionnaires; D013702:Temporal Lobe / Q000502:physiology