Liver X receptor antagonists with a phthalimide skeleton derived from thalidomide-related glucosidase inhibitors.
Alpha-glucosidase inhibitors with a chlorinated phthalimide or a thiophthalimide skeleton, derived from thalidomide, were found to possess liver X receptor (LXR) antagonistic activity. Novel LXR antagonists with a 2'-substituted phenylphthalimide skeleton were obtained by structural development of glucosidase inhibitors derived from thalidomide.
Noguchi-Yachide
Tomomi
T
Institute of Molecular and Cellular Biosciences, University of Tokyo, 1-1-1 Yayoi, Tokyo 113-0032, Japan.
Aoyama
Atsushi
A
Makishima
Makoto
M
Miyachi
Hiroyuki
H
Hashimoto
Yuichi
Y
D002460:Cell Line; D004268:DNA-Binding Proteins / Q000037:antagonists & inhibitors*; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D005959:Glucosidases / Q000037:antagonists & inhibitors*; D006801:Humans; D000071518:Liver X Receptors; D015394:Molecular Structure; D057093:Orphan Nuclear Receptors; D010797:Phthalimides / Q000737:chemistry*; D018160:Receptors, Cytoplasmic and Nuclear / Q000037:antagonists & inhibitors*; D013792:Thalidomide / Q000737:chemistry*
D004268:DNA-Binding Proteins; D004791:Enzyme Inhibitors; D000071518:Liver X Receptors; D057093:Orphan Nuclear Receptors; D010797:Phthalimides; D018160:Receptors, Cytoplasmic and Nuclear; D013792:Thalidomide; D005959:Glucosidases