title: Localized retinal nerve fiber layer defects and visual field abnormalities by humphrey matrix frequency doubling technology perimetry.
abstract: OBJECTIVE
  To investigate the ability of frequency doubling technology (FDT) perimetry to identify eyes with a localized retinal nerve fiber layer (RNFL) defect and normal Humphrey C30-2 SITA-Standard visual field (HVF).
  
  
  METHODS
  Retrospective case-control study.
  
  
  METHODS
  Fifty-four eyes were divided into two groups, an abnormal (n = 29) and a normal (n = 25) FDT perimetry group. Approximation of the RNFL defect to the macula (angle alpha) and width of the defect (angle beta) were measured by RNFL photograph and compared between two groups.
  
  
  RESULTS
  Angle alpha and angle beta were significantly different between two groups (P < .001 by Mann-Whitney U test, respectively). A multivariate logistic regression analysis demonstrated that only angle beta was significantly associated with FDT perimetry abnormalities (P = .002).
  
  
  CONCLUSIONS
  Only 53.7% of the eyes with a localized RNFL defect and normal HVF had visual field abnormalities identified by FDT perimetry. Width of the RNFL defect was more strongly associated with FDT perimetry abnormalities than location of the defect.
authors.affiliation: Department of Ophthalmology, Seoul National University Hospital, Seoul, Korea.
authors.forename: Min Joung
authors.initials: MJ
authors.lastname: Lee
authors.forename: Dong Myung
authors.initials: DM
authors.lastname: Kim
authors.forename: Jin Wook
authors.initials: JW
authors.lastname: Jeoung
authors.forename: Seung-Sik
authors.initials: SS
authors.lastname: Hwang
authors.forename: Tae Woo
authors.initials: TW
authors.lastname: Kim
authors.forename: Ki Ho
authors.initials: KH
authors.lastname: Park
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology*; D009901:Optic Nerve Diseases / Q000175:diagnosis*; D012165:Retinal Ganglion Cells / Q000473:pathology*; D012189:Retrospective Studies; D014786:Vision Disorders / Q000175:diagnosis*; D058609:Visual Field Tests / Q000379:methods*; D014794:Visual Fields