title: [Towards the computational three-dimensional histology. Application of computer models to the reconstruction of the three-dimensional structure of the biological tissue with the sensory cochlear acoustic epithelium in birds as an example].
abstract: This article presents new efficient method of 3-D structure reconstruction of epithelia. In contrast to existing empirical approaches, this method is based on the use of the families of topological and geometrical models of tissue structure, obtained from the axiomatic theory of biological tissue structure, with the database of model sections obtained by computer simulation. This methodology involves comparison of tissue sections obtained with those taken from the database of theoretically predicted models and the selection of the model, the sections of which best fit the real ones. This approach significantly reduces the amount of necessary tissue sections and eliminates the need for their precise superposition. As a result, new method improves resolution and and the efficiency of the studies of the spatial organization of epithelia, at the same time simplifying them. This approach is oriented primarily on examination of tissue topology as the most important aspect of its histoarchitectonics. Application of the models also facilitates the evaluation of geometrical properties of the tissue and even allows to predict their transformations, thus creating the real prerequisite for transition to the 3-D histology.
authors.forename: E G
authors.initials: EG
authors.lastname: Savost'ianova
authors.forename: A V
authors.initials: AV
authors.lastname: Vorob'ev
authors.forename: N M
authors.initials: NM
authors.lastname: Grefner
authors.forename: V F
authors.initials: VF
authors.lastname: Levchenko
authors.forename: G A
authors.initials: GA
authors.lastname: Savost'ianov
mesh_terms: D000818:Animals; D001717:Birds / Q000033:anatomy & histology*; D003051:Cochlea / Q000166:cytology*; D004848:Epithelium / Q000033:anatomy & histology; D021621:Imaging, Three-Dimensional; D008953:Models, Anatomic