Review of breast cancer clinical trials conducted by the National Surgical Adjuvant Breast Project.
The National Surgical Adjuvant Breast Project (NSABP) is a clinical trials cooperative group funded by the National Cancer Institute that has been responsible for the majority of prospective, randomized studies that have defined standards of breast cancer care in the United States during the past 4 decades. This article summarizes the design of and findings from a selection of their landmark studies. Results from their many successfully completed trials have been reported as subset analyses, pooled analyses, and retrospective studies. This article focuses on presenting the study designs, aims, and primary endpoint results of these studies.
Newman
Lisa A
LA
Breast Care Center, University of Michigan, 1500 East Medical Center Drive, 3308 CGC, Ann Arbor, MI 48109-0932, USA. lanewman@umich.edu
Mamounas
Eleftherios P
EP
D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000235:genetics / Q000601:surgery*; D002278:Carcinoma in Situ / Q000601:surgery; D018270:Carcinoma, Ductal, Breast / Q000601:surgery; D017024:Chemotherapy, Adjuvant; D002986:Clinical Trials as Topic; D005260:Female; D018734:Genes, erbB-2 / Q000235:genetics; D006801:Humans; D008207:Lymphatic Metastasis / Q000473:pathology; D015409:Mastectomy, Radical; D015412:Mastectomy, Segmental; D015413:Mastectomy, Simple; D009316:National Institutes of Health (U.S.); D020360:Neoadjuvant Therapy; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control / Q000628:therapy; D011446:Prospective Studies; D018714:Radiotherapy, Adjuvant; D016032:Randomized Controlled Trials as Topic; D011960:Receptors, Estrogen / Q000032:analysis / Q000187:drug effects; D012107:Research Design; D021701:Sentinel Lymph Node Biopsy; D016896:Treatment Outcome; D014481:United States
D018931:Antineoplastic Agents, Hormonal; D011960:Receptors, Estrogen