title: Prostate cancer tissue is masked by bicalutamide: a case report.
abstract: Prostate cancer is the most common malignant tumor in men. Recently, a slightly decreased frequency of margin positivity following neoadjuvant bicalutamide treatment due to tumor shrinkage was reported. Trials investigating other anti-androgens in the past also reported lower frequencies of surgical margin positivity, but patients outcome has not improved. In this case, local recurrence was confirmed by needle biopsy in a patient five years following radical prostatectomy for prostate adenocarcinoma. After therapy with 50 mg bicalutamide for a month, the tumour was resected. Despite of detailed histological work-up and immunohistochemistry cancer suspicious lesions were not found. We think that bicalutamide may be capable of masking prostate cancer cells.
authors.affiliation: Klinik und Poliklinik für Urologie, Universitätsklinikum Bonn, Sigmund-Freud-Str. 25, 53105 Bonn, Germany. joerg.ellinger@ukb.uni-bonn.de
authors.forename: J
authors.initials: J
authors.lastname: Ellinger
authors.forename: P J
authors.initials: PJ
authors.lastname: Bastian
authors.forename: K
authors.initials: K
authors.lastname: Biermann
authors.forename: M E
authors.initials: ME
authors.lastname: Schmidt
authors.forename: J
authors.initials: J
authors.lastname: Textor
authors.forename: D
authors.initials: D
authors.lastname: Bollmann
authors.forename: H
authors.initials: H
authors.lastname: Zhou
authors.forename: S C
authors.initials: SC
authors.lastname: Müller
mesh_terms: D000230:Adenocarcinoma / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D000726:Androgen Antagonists / Q000009:adverse effects*; D000813:Anilides / Q000009:adverse effects*; D001707:Biopsy, Needle; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D009364:Neoplasm Recurrence, Local / Q000097:blood / Q000473:pathology*; D009570:Nitriles / Q000009:adverse effects*; D011467:Prostate / Q000187:drug effects; D017430:Prostate-Specific Antigen / Q000097:blood; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D014105:Tosyl Compounds / Q000009:adverse effects*
chemical_list: D000726:Androgen Antagonists; D000813:Anilides; D009570:Nitriles; D014105:Tosyl Compounds; C053541:bicalutamide; D017430:Prostate-Specific Antigen