title: Topical minocycline and tetracycline rinses in treatment of recurrent aphthous stomatitis: a randomized cross-over study.
abstract: Recurrent aphthous stomatitis (RAS) is a common ulcerative condition of the oral mucosa. We assessed minocycline and tetracycline oral rinses in patients with frequent episodes of RAS in a clinical randomized crossover trial. Seventeen patients with high frequency recurrent minor RAS were randomly allocated to a cross-over topical therapy with 0.2 percent minocycline or 0.25 percent tetracycline aqueous solution mouthwash. The minimum interval between the cross-over was 30 days. The intensity of pain was recorded daily using a visual analogue scale. Minocycline mouthwashes as compared to topical tetracycline rinses resulted in significantly improved pain control, by reducing the severity and duration of pain. Topical minocycline rinse may be a potential treatment for other mucosal diseases that result in mucosal ulceration and pain.
authors.affiliation: Department of Oral Pathology and Oral Medicine, the Maurice and Gabriella Goldschleger School of Dental Medicine, Tel Aviv University, Israel.
authors.forename: Meir
authors.initials: M
authors.lastname: Gorsky
authors.forename: Joel
authors.initials: J
authors.lastname: Epstein
authors.forename: Shira
authors.initials: S
authors.lastname: Rabenstein
authors.forename: Hanita
authors.initials: H
authors.lastname: Elishoov
authors.forename: Noam
authors.initials: N
authors.lastname: Yarom
mesh_terms: D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D000368:Aged; D018592:Cross-Over Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008911:Minocycline / Q000627:therapeutic use*; D009061:Mouth Mucosa / Q000187:drug effects; D009067:Mouthwashes / Q000627:therapeutic use; D010147:Pain Measurement; D017060:Patient Satisfaction; D012008:Recurrence; D018570:Risk Assessment; D012720:Severity of Illness Index; D013281:Stomatitis, Aphthous / Q000175:diagnosis* / Q000188:drug therapy*; D013752:Tetracycline / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D009067:Mouthwashes; D013752:Tetracycline; D008911:Minocycline