NADH dehydrogenase subunit-2 237 Leu/Met polymorphism modifies the effects of alcohol consumption on risk for hypertension in middle-aged Japanese men.
NADH dehydrogenase subunit-2 237 leucine/methionine (ND2-237 Leu/Met) polymorphism is associated with longevity in the Japanese population, and the ND2-237Met genotype may exert antiatherogenic effects. To investigate whether ND2-237 Leu/Met polymorphism is associated with risk of hypertension, we conducted a cross-sectional study of 398 Japanese male subjects. The frequency of hypertension was significantly higher in ND2-237Leu genotypic men than in ND2-237Met genotypic men. On analysis of covariance, the interaction between ND2-237 Leu/Met polymorphism and habitual drinking was significantly associated with both systolic blood pressure and diastolic blood pressure. Multiple logistic regression analysis revealed that the ND2-237Met genotype, particularly in younger subjects (age <60 years), had a lower odds ratio for hypertension than the ND2-237Leu genotype. Moreover, the association of ND2-237 Leu/Met polymorphism with hypertension may depend on the frequency of alcohol consumption. The odds ratio for hypertension was significantly higher in daily drinkers with ND2-237Leu when compared with non- or ex-drinkers with ND2-237Leu. However, the association between the ND2-237Met genotype and hypertension may not depend on the frequency of alcohol consumption. The present results suggest that ND2-237 Leu/Met polymorphism is associated with hypertension and that modification of hypertension risk is dependent on alcohol consumption in middle-aged Japanese men.
Kokaze
Akatsuki
A
Department of Public Health, Kyorin University School of Medicine, Mitaka, Japan. dawn@kyorin-u.ac.jp
Ishikawa
Mamoru
M
Matsunaga
Naomi
N
Yoshida
Masao
M
Satoh
Masao
M
Teruya
Koji
K
Masuda
Yumi
Y
Honmyo
Rie
R
Uchida
Yoshiko
Y
Takashima
Yutaka
Y
D000428:Alcohol Drinking / Q000235:genetics* / Q000503:physiopathology; D044466:Asian People / Q000235:genetics; D001794:Blood Pressure / Q000502:physiology; D003430:Cross-Sectional Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000453:epidemiology / Q000235:genetics* / Q000503:physiopathology; D007564:Japan / Q000453:epidemiology; D007930:Leucine / Q000235:genetics*; D008297:Male; D008715:Methionine / Q000235:genetics*; D008875:Middle Aged; D009245:NADH Dehydrogenase / Q000235:genetics* / Q000378:metabolism; D012150:Polymorphism, Restriction Fragment Length; D021122:Protein Subunits; D012307:Risk Factors
D021122:Protein Subunits; D008715:Methionine; D009245:NADH Dehydrogenase; C521326:NADH dehydrogenase subunit 2, human; D007930:Leucine