title: Nitrofurantoin-induced lung- and hepatotoxicity.
abstract: We present the case of a patient referred to the gastroenterology service for investigation of abnormal liver function tests. She had been taking nitrofurantoin for 16 months as prophylaxis against urinary tract infections. CT scan showed evidence of lung pneumonitis and low attenuation in the liver parenchyma. Nitrofurantoin-induced pneumonitis and hepatotoxicity was diagnosed. The patient responded both clinically and biochemically to withdrawal of nitrofurantoin. This combination of adverse reaction to nitrofurantoin is rare.
authors.affiliation: Department of Gastroenterology, Warrington Hospital, Warrington. akoulaouzidis@hotmail.com
authors.forename: Anastasios
authors.initials: A
authors.lastname: Koulaouzidis
authors.forename: Shivaram
authors.initials: S
authors.lastname: Bhat
authors.forename: John
authors.initials: J
authors.lastname: Moschos
authors.forename: Chew
authors.initials: C
authors.lastname: Tan
authors.forename: Ana
authors.initials: A
authors.lastname: De Ramon
mesh_terms: D000892:Anti-Infective Agents, Urinary / Q000008:administration & dosage / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000000981:diagnostic imaging* / Q000209:etiology; D005260:Female; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging; D008168:Lung / Q000000981:diagnostic imaging; D008875:Middle Aged; D009582:Nitrofurantoin / Q000008:administration & dosage / Q000009:adverse effects*; D011014:Pneumonia / Q000139:chemically induced / Q000000981:diagnostic imaging*; D013902:Radiography, Thoracic; D014057:Tomography, X-Ray Computed; D014552:Urinary Tract Infections / Q000517:prevention & control
chemical_list: D000892:Anti-Infective Agents, Urinary; D009582:Nitrofurantoin