title: HLA alleles as predisposal factors for postmenopausal osteoporosis in a Greek population.
abstract: It is well established that genetic factors play an important role in the pathogenesis of osteoporosis, a common condition characterized by reduced bone mass and increased fracture risk. The major histocompatibility complex in humans, known as human leukocyte antigen (HLA) region, is the most polymorphic human genetic system and it is known as a cluster of genetic markers, associated with several diseases. In order to evaluate the contribution of HLA alleles in bone mass loss, polymorphisms in the HLA class I (-A, -B and -Cw) and class II (-DR and -DQ) antigens were studied in 126 postmenopausal women of Greek origin. It was found that HLA-B7 (P= 0.069), -DR15 (P= 0.019) and -DQ6 (P= 0.026) were associated with a lower bone mineral density measured at the forearm. This study shows a significant association between HLA alleles and bone mass loss in the population studied.
authors.affiliation: Department of Immunology and Histocompatibility, Evangelismos Hospital, Athens, Greece. drkmb@email.com
authors.forename: K
authors.initials: K
authors.lastname: Douroudis
authors.forename: K
authors.initials: K
authors.lastname: Tarassi
authors.forename: T
authors.initials: T
authors.lastname: Athanassiades
authors.forename: F
authors.initials: F
authors.lastname: Giannakopoulos
authors.forename: A
authors.initials: A
authors.lastname: Kominakis
authors.forename: N
authors.initials: N
authors.lastname: Thalassinos
authors.forename: Ch
authors.initials: Ch
authors.lastname: Papasteriades
mesh_terms: D000483:Alleles; D015519:Bone Density / Q000235:genetics; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D006115:Greece; D006680:HLA Antigens / Q000235:genetics*; D015793:HLA-B7 Antigen / Q000235:genetics; D006683:HLA-DQ Antigens / Q000235:genetics; D006684:HLA-DR Antigens / Q000235:genetics; D059810:HLA-DR Serological Subtypes; D006801:Humans; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000235:genetics* / Q000276:immunology* / Q000503:physiopathology; D012307:Risk Factors
chemical_list: D006680:HLA Antigens; D015793:HLA-B7 Antigen; D006683:HLA-DQ Antigens; C063831:HLA-DQ6 antigen; D006684:HLA-DR Antigens; D059810:HLA-DR Serological Subtypes; C106559:HLA-DR15 antigen