Immunological synapses: breaking up may be good to do.
Activated T cells form stable immunological synapses with antigen-presenting cells whereas naïve T cells initially engage in more transient interactions. Sims et al. (2007) demonstrate that these transient interactions are due to the kinase PKCtheta, which serves to destabilize the synapse thereby permitting T cells to migrate elsewhere. They also show that re-establishment of a synapse involves the actin regulator WASp.
Krummel
Matthew F
MF
The Department of Pathology, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143-0511, USA. matthew.krummel@ucsf.edu
D000818:Animals; D017951:Antigen Presentation / Q000276:immunology; D002450:Cell Communication / Q000276:immunology*; D002465:Cell Movement / Q000276:immunology; D006801:Humans; D007527:Isoenzymes / Q000276:immunology; D008213:Lymphocyte Activation / Q000276:immunology*; D011493:Protein Kinase C / Q000276:immunology; D000074121:Protein Kinase C-theta; D015398:Signal Transduction / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D051300:Wiskott-Aldrich Syndrome Protein Family / Q000378:metabolism
D007527:Isoenzymes; D051300:Wiskott-Aldrich Syndrome Protein Family; C076233:PRKCQ protein, human; D011493:Protein Kinase C; D000074121:Protein Kinase C-theta