title: In search of new cures for tuberculosis.
abstract: The last 10 years have seen resurgent industry activity in discovery and development of new drugs for the treatment of tuberculosis (TB), a growing widespread and devastating (more than 2 million deaths annually) bacterial infection that is of increasing concern in developing and developed nations alike. This review describes drugs currently being evaluated in the clinic for treatment of uncomplicated and drug resistant pulmonary TB, and updates the literature on 5 new drugs that entered clinical trials in the last 4 years.
authors.affiliation: Sequella, Inc., 9610 Medical Center Drive, Suite 200, Rockville, MD 20850, USA. marinaprotopopova@sequella.com
authors.forename: Marina
authors.initials: M
authors.lastname: Protopopova
authors.forename: Elena
authors.initials: E
authors.lastname: Bogatcheva
authors.forename: Boris
authors.initials: B
authors.lastname: Nikonenko
authors.forename: Sam
authors.initials: S
authors.lastname: Hundert
authors.forename: Leo
authors.initials: L
authors.lastname: Einck
authors.forename: Carol A
authors.initials: CA
authors.lastname: Nacy
mesh_terms: D000995:Antitubercular Agents / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D013329:Structure-Activity Relationship; D016896:Treatment Outcome; D014376:Tuberculosis / Q000188:drug therapy*
chemical_list: D000995:Antitubercular Agents