Comparison of central corneal thickness measurements by visante anterior segment optical coherence tomography with ultrasound pachymetry.
OBJECTIVE
To compare the measurement of the central corneal thickness (CCT) by Visante (Carl Zeiss Meditec, Dublin, California, USA) anterior segment optical coherence tomography (AS-OCT) with ultrasound pachymetry.


METHODS
Population-based, cross-sectional study.


METHODS
Participants were part of a population-based study of 3280 Malay subjects aged 40 to 80 years in Singapore. Ultrasound pachmetry of CCT was performed on all participants and approximately 10% underwent further evaluation with AS-OCT.


RESULTS
Two hundred and eighty-five consecutive subjects were included, with a mean age of 57.9 (+/- 10.8) years. CCT as measured by ultrasound pachymetry was highly correlated with the equivalent AS-OCT reading (The Pearson correlation coefficient = 0.93, P < .001). However, Bland-Altman analysis showed that CCT as measured by ultrasound pachymetry was significantly higher by 16.5 +/- 11.7 microm (limits of agreement -6.1 to 39.1, P < .001).


CONCLUSIONS
CCT measured by Visante AS-OCT was highly correlated with that from ultrasound pachymetry. However, CCT readings by Visante AS-OCT were consistently less than that of ultrasound pachymetry.
Zhao
Paul S
PS
Singapore Eye Research Institute and Singapore National Eye Centre, Singapore.
Wong
Tien Yin
TY
Wong
Wan-Ling
WL
Saw
Seang-Mei
SM
Aung
Tin
T
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001837:Body Weights and Measures; D003315:Cornea / Q000033:anatomy & histology* / Q000000981:diagnostic imaging*; D003430:Cross-Sectional Studies; D003941:Diagnostic Techniques, Ophthalmological / Q000295:instrumentation*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D041623:Tomography, Optical Coherence / Q000379:methods*; D014463:Ultrasonography / Q000379:methods*