Short-interval intracortical inhibition is modulated by high-frequency peripheral mixed nerve stimulation.
Cortical excitability can be modulated by manipulation of afferent input. We investigated the influence of peripheral mixed nerve stimulation on the excitability of the motor cortex. Motor evoked potentials (MEPs), short-interval intracortical inhibition (SICI) and intracortical facilitation (ICF) in the right abductor pollicis brevis (APB), extensor carpi radialis (ECR) and first dorsal interosseous (FDI) muscles were evaluated using paired-pulse transcranial magnetic stimulation (TMS) before and after high-frequency peripheral mixed nerve stimulation (150 Hz, 30 min) over the right median nerve at the wrist. The MEP amplitude and SICI of the APB muscle decreased transiently 0-10 min after the intervention, whereas the ICF did not change. High-frequency peripheral mixed nerve stimulation reduced the excitability of the motor cortex. The decrement in the SICI, which reflects the function of GABA(A)ergic inhibitory interneurons, might compensate for the reduced motor cortical excitability after high-frequency peripheral mixed nerve stimulation.
Murakami
Takenobu
T
Department of Neurology, Institute of Neurological Sciences, Faculty of Medicine, Tottori University, 36-1 Nishicho, Yonago 683-8504, Japan.
Sakuma
Kenji
K
Nomura
Takashi
T
Nakashima
Kenji
K
D000328:Adult; D002540:Cerebral Cortex / Q000502:physiology*; D004558:Electric Stimulation; D005260:Female; D006801:Humans; D008297:Male; D008475:Median Nerve / Q000502:physiology; D009044:Motor Cortex / Q000502:physiology; D018482:Muscle, Skeletal / Q000294:innervation / Q000502:physiology; D009473:Neuronal Plasticity / Q000502:physiology; D010525:Peripheral Nerves / Q000502:physiology*; D011963:Receptors, GABA-A / Q000502:physiology; D013003:Somatosensory Cortex / Q000502:physiology; D050781:Transcranial Magnetic Stimulation; D055815:Young Adult
D011963:Receptors, GABA-A