title: Changes in QT dispersion after thrombolysis for stroke.
abstract: BACKGROUND
  QT dispersion (QTD) reflects heterogeneity of myocardial repolarization, which is modulated by the central nervous system. Although largely studied in patients with cardiovascular disease, QTD is increased in acute stroke and this finding is an independent predictor of functional outcome and mortality following acute neurological events.
  
  
  OBJECTIVE
  The hypothesis of this study was to determine whether changes in QTD in patients presenting with ischemic stroke parallel changes in neurologic function.
  
  
  METHODS
  We retrospectively studied 30 consecutive patients (76+/-9 years, 50% male) who received thrombolytic therapy for acute ischemic stroke between September 1996 and August 2002, and had multiple electrocardiograms (ECGs). QTD was calculated from the admission ECG and the last available ECG (median 3 days) during hospital admission as the absolute difference between the maximum and minimum QT intervals in at least 11 of 12 leads. The National Institute of Health Stroke Scale (NIHSS) was used to assess neurological status on admission and discharge. DeltaQTD was calculated as the absolute difference between QTD measured on admission and on the last available ECG. Absolute changes in heart rate corrected QTD (DeltaQTDc) and NIHSS scores (DeltaNIHSS) were also calculated.
  
  
  RESULTS
  DeltaQTD was significantly higher in the 27% of patients who died as compared to the survivors (44+/-26 ms vs. -2+/-21 ms, p<.001). DeltaNIHSS correlated directly with DeltaQTD (r=0.57, p<0.001) and with DeltaQTDc (r=0.60, p<0.001). The NIHSS score changed in the same direction 3.1 units (95% CI: 2.0, 4.2) for every 10 ms change in QTD.
  
  
  CONCLUSIONS
  DeltaQTD are associated with changes in neurological function in patients treated with thrombolytic therapy for acute ischemic stroke.
authors.affiliation: Division of Cardiovascular Medicine, State University of New York Downstate Medical Center, Brooklyn, New York 11203-2098, USA. jason.lazar@downstate.edu
authors.forename: Jason
authors.initials: J
authors.lastname: Lazar
authors.forename: David
authors.initials: D
authors.lastname: Busch
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Wirkowski
authors.forename: Luther T
authors.initials: LT
authors.lastname: Clark
authors.forename: Louis
authors.initials: L
authors.lastname: Salciccioli
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000175:diagnosis / Q000503:physiopathology*; D004562:Electrocardiography / Q000639:trends*; D005260:Female; D006801:Humans; D008133:Long QT Syndrome / Q000139:chemically induced / Q000175:diagnosis / Q000503:physiopathology; D008297:Male; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D020521:Stroke / Q000175:diagnosis / Q000503:physiopathology* / Q000628:therapy*; D015912:Thrombolytic Therapy / Q000009:adverse effects / Q000639:trends*