[Risk factors of operation and reoperation in patients with Crohn disease].
OBJECTIVE
To explore the operative rate and reoperative rate of Crohn disease(CD) in China, and to assess the relative risk factors indicating surgical treatment in CD patients.


METHODS
Data of initial operation and reoperation were evaluated retrospectively in a cohort of 142 patients with CD. The influence of concomitant risk factors was assessed using multivariate analyses.


RESULTS
Of the 142 cases of CD patients, 64.8% required at least one operation and the cumulative rate of operation was 52% at 5 years after onset. The relative risk of operation was increased in male patients, older than 40 years of age at onset, and those with CD involving small bowel. Of the patients undergone operation, 33.9% relapsed and required reoperation subsequently. The cumulative reoperation rate was 21% at 3 years after first operation. Male gender, a perforating indication for initial operation, as well as colonic and ileocolonic disease, increased the relative risks of reoperation.


CONCLUSIONS
Half of patients with CD will undergo an operation at 5 years after onset, and 20% of them will relapse and require reoperation at 3 years after first operation. Men run a higher risk of operation and reoperation than women do. A perforating indication for initial operation predict a higher risk of reoperation.
Wang
Jian-ping
JP
Department of Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China. wjp@sysu.edu.cn
Huang
Mei-xiong
MX
Yin
Lu
L
Qian
Qun
Q
Lan
Ping
P
Wang
Ting
T
He
Xiao-sheng
XS
D000293:Adolescent; D000328:Adult; D003424:Crohn Disease / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D012086:Reoperation / Q000009:adverse effects*; D012189:Retrospective Studies; D012307:Risk Factors; D012737:Sex Factors; D055815:Young Adult