Pericarditis: a rare complication of methotrexate therapy.
Serositis is a rare complication of methotrexate (MTX) administration. We report a 60-year-old man with rheumatoid arthritis who developed pericarditis after taking his weekly MTX dose, which recurred within hours after 2 subsequent weekly MTX doses. Pericarditis has not recurred after discontinuance of MTX over 3 years ago. We conclude that he had MTX-induced pericarditis, based on the close temporal relationship between MTX ingestion and manifestations of pericarditis on three distinct occasions because of the previous reports of MTX-induced pericarditis and because pericarditis has not recurred after MTX withdrawal.
Mohyuddin
Tayyab
T
MetroHealth Medical Center, 2500 MetroHealth Drive, Cleveland, OH, 44109, USA.
Elyan
Mazen
M
MetroHealth Medical Center, 2500 MetroHealth Drive, Cleveland, OH, 44109, USA.
Kushner
Irving
I
MetroHealth Medical Center, 2500 MetroHealth Drive, Cleveland, OH, 44109, USA. ikushner@metrohealth.org.
D018501:Antirheumatic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D003937:Diagnosis, Differential; D015150:Echocardiography, Doppler; D004562:Electrocardiography; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000009:adverse effects* / Q000627:therapeutic use; D008875:Middle Aged; D010493:Pericarditis / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D011241:Prednisone / Q000627:therapeutic use; D013902:Radiography, Thoracic; D036542:Tomography, Spiral Computed
D018501:Antirheumatic Agents; D005938:Glucocorticoids; D011241:Prednisone; D008727:Methotrexate