title: Epithelioid cell clusters with an extensive lymphoid background.
abstract: BACKGROUND
  Fine-needle aspiration of salivary gland lesions can be particularly challenging for pathologists. There are numerous neoplasms that occur in this area and several cytologic variations of each specific lesion.
  
  
  OBJECTIVE
  To present and discuss a practical pattern recognition approach to fine-needle aspiration diagnosis, which includes categorizing lesions that share a certain overall cytologic architectural pattern, followed by identifying unique cellular characteristics that are specific to a certain lesion. An extensive discussion of one cytologic common pattern of salivary gland lesions, "epithelioid cell clusters with an extensive lymphoid background," is presented. The pathologic entities that fall under this architectural pattern group are discussed, with an emphasis on neoplasms.
  
  
  METHODS
  Published literature and personal experience.
  
  
  CONCLUSIONS
  A practical cytologic architectural pattern method can aid the pathologist in rendering a correct diagnosis when evaluating salivary gland lesions. One common pattern in salivary gland cytopathology is epithelioid cell clusters with an extensive lymphoid background. This pattern is often associated with Warthin tumor; however, other benign and malignant entities fall under this diagnostic group. Unique cytologic features separate these lesions into their respective diagnostic category.
authors.affiliation: Department of Laboratory Medicine and Pathology, Mayo Clinic Arizona, 13400 E Shea Blvd, Scottsdale, AZ 85259, USA. zarka.matthew@mayo.edu
authors.forename: Matthew A
authors.initials: MA
authors.lastname: Zarka
mesh_terms: D001707:Biopsy, Needle; D004848:Epithelium / Q000473:pathology; D006801:Humans; D008214:Lymphocytes / Q000473:pathology; D012468:Salivary Gland Neoplasms / Q000473:pathology*; D012469:Salivary Glands / Q000473:pathology*