Perinatal alcohol exposure enhances nocistatin levels in adulthood.
In earlier experiments perinatal hormonal imprinting by alcohol decreased the hormone content of immune cells for life. In the present study, both a single day (15% on the third postnatal day) and a long-term treatment schedule of alcohol exposure (3% for 21 days) of dams during lactation significantly (P < 0.01) enhanced endogenous levels of nocistatin in the blood plasma as well as in the cerebrospinal fluid of the offspring, measured in 3-month-old rats. Our data suggest that alcohol consumption during lactation can cause a life-long influence on nocistatin levels in the offspring and most likely modify nocistatin-related functions such as pain tolerance.
Tekes
Kornélia
K
Department of Pharmacodynamics, Semmelweis University, Budapest, Hungary. tekkor@net.sote.hu
Hantos
Mónika
M
Gyenge
Melinda
M
Csaba
Gyorgy
G
D000367:Age Factors; D000437:Alcoholism / Q000503:physiopathology*; D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000633:toxicity*; D005260:Female; D007173:Imprinting, Psychological / Q000187:drug effects*; D007774:Lactation; D018847:Opioid Peptides / Q000378:metabolism*; D017288:Pain Threshold / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar
D018847:Opioid Peptides; C111148:nocistatin; D000431:Ethanol