Progress in shivering control.
Hypothermia is a potent neuroprotectant and induced hypothermia holds great promise as a therapy for acute neuronal injury. Thermoregulatory responses, most notably shivering, present major obstacles to therapeutic temperature management. A review of thermoregulatory physiology and strategies aimed at controlling physiologic responses to hypothermia is presented.
Mahmood
M Asim
MA
University of South Alabama Stroke Center, Suite 10-I, 2451 Fillingim Street, Mobile, AL 36617, USA.
Zweifler
Richard M
RM
D000316:Adrenergic alpha-Agonists / Q000494:pharmacology; D000701:Analgesics, Opioid / Q000494:pharmacology; D000777:Anesthetics / Q000494:pharmacology; D001833:Body Temperature Regulation / Q000502:physiology*; D006801:Humans; D007035:Hypothermia / Q000517:prevention & control*; D009126:Muscle Relaxation / Q000502:physiology; D012702:Serotonin Antagonists / Q000494:pharmacology; D017366:Serotonin Receptor Agonists / Q000494:pharmacology; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology; D012768:Shivering / Q000187:drug effects / Q000502:physiology*
D000316:Adrenergic alpha-Agonists; D000701:Analgesics, Opioid; D000777:Anesthetics; D012702:Serotonin Antagonists; D017366:Serotonin Receptor Agonists; D017367:Selective Serotonin Reuptake Inhibitors