title: Visual impairment in Parkinson's disease treated with amantadine: case report and review of the literature.
abstract: A 61-year-old man with Parkinson's disease (PD) developed sudden-onset visual impairment after initiation of amantadine treatment. Ophthalmologic examination revealed corneal endothelial edema. Discontinuation of amantadine resulted in rapid improvement of visual acuity. A review of the literature indicated only a few reports of amantadine-associated corneal dysfunction in patients with neurological disorders as well as influenza syndrome, but none with PD. Amantadine-associated visual impairment in PD could be possibly overlooked, since PD mainly affects elderly people who often develop aging-related ocular changes. The present report alerts neurologists and physicians in general to the peculiar ophthalmologic side effect of amantadine.
authors.affiliation: Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan. skubo@med.juntendo.ac.jp <skubo@med.juntendo.ac.jp>
authors.forename: Shin-ichiro
authors.initials: S
authors.lastname: Kubo
authors.forename: Akira
authors.initials: A
authors.lastname: Iwatake
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Ebihara
authors.forename: Akira
authors.initials: A
authors.lastname: Murakami
authors.forename: Nobutaka
authors.initials: N
authors.lastname: Hattori
mesh_terms: D000547:Amantadine / Q000627:therapeutic use*; D000978:Antiparkinson Agents / Q000627:therapeutic use*; D003315:Cornea / Q000473:pathology; D004728:Endothelium, Corneal / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications*; D014786:Vision Disorders / Q000188:drug therapy* / Q000209:etiology*; D014792:Visual Acuity
chemical_list: D000978:Antiparkinson Agents; D000547:Amantadine