title: Kinase clamping.
abstract: By introducing two point mutations in the ATP-binding pockets of kinases, researchers can specifically and irreversibly inhibit these enzymes and determine how much kinase activity is needed for downstream signaling.
authors.forename: Nicole
authors.initials: N
authors.lastname: Rusk
mesh_terms: D003545:Cysteine / Q000235:genetics; D010770:Phosphotransferases / Q000037:antagonists & inhibitors* / Q000235:genetics; D017354:Point Mutation; D011799:Quinazolines / Q000494:pharmacology
chemical_list: D011799:Quinazolines; D010770:Phosphotransferases; D003545:Cysteine