Overexpression of RhoE has a prognostic value in non-small cell lung cancer.
BACKGROUND
Increasing evidence has suggested that RhoE plays an important role in carcinogenesis and progression. However, the correlation between RhoE expression and clinical outcome in lung cancer has not been investigated.


METHODS
RhoE expression was detected by immunohistochemistry on tissue microarray containing samples from 115 patients with non-small cell lung cancer with a median follow-up of 54 months.


RESULTS
RhoE was overexpressed in the cytoplasm of lung cancer cells compared with undetectable expression of RhoE in the adjacent nontumoral cells. Patients with RhoE-negative tumors had substantially longer cancer-related survival than did patients with RhoE-positive tumors. Multivariate analysis showed that RhoE overexpression was an independent marker for cancer-related survival in the entire population after adjusting for other prognostic factors.


CONCLUSIONS
RhoE expression may serve as an unfavorable prognostic factor in patients with non-small cell lung cancer.
Zhang
Cuiyan
C
Department of Thoracic Surgery, Peking Union Medical College, Chinese Academy of Medical Sciences, 100021, Beijing, China.
Zhou
Fang
F
Li
Ning
N
Shi
Susheng
S
Feng
Xiaoli
X
Chen
Zhaoli
Z
Hang
Jie
J
Qiu
Bin
B
Li
Baozhong
B
Chang
Sheng
S
Wan
Junting
J
Shao
Kang
K
Xing
Xuezhong
X
Tan
Xiaogang
X
Wang
Zhen
Z
Xiong
Meihua
M
He
Jie
J
D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism; D015153:Blotting, Western; D002289:Carcinoma, Non-Small-Cell Lung / Q000378:metabolism*; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008175:Lung Neoplasms / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016016:Proportional Hazards Models; D016019:Survival Analysis; D015854:Up-Regulation; D020741:rho GTP-Binding Proteins / Q000378:metabolism*
D014408:Biomarkers, Tumor; C508705:RND3 protein, human; D020741:rho GTP-Binding Proteins