title: [Gastroesophageal reflux disease in diabetic patients].
abstract: Esophageal dysfunctions occur frequently in patients with diabetic neuropathy, and the complication of gastroesophageal reflux disease(GERD) has also been reported. However, the characteristics of GERD complicated with diabetes mellitus are obscure because no detailed assessment was performed. We performed long-term ambulatory esophageal pH and motility monitoring in diabetic patients, and analyzed the data in detail. Esophageal dysfunctions including GERD were significantly related to diabetic neuropathy and duration. Although GERD was frequently complicated with diabetes mellitus, the symptoms were not apparent in diabetic patients. The average score of a questionnaire was extremely low, and no significant difference in score was observed between patients with and without gastroesophageal reflux. We should keep in mind that diabetic patients have the abnormal gastroesophageal reflux even when they do not complain of the related symptoms.
authors.affiliation: Department of Gastroenterology and Neurology, Kagawa University School of Medicine.
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Kinekawa
authors.forename: Fumiyoshi
authors.initials: F
authors.lastname: Kubo
authors.forename: Kazuya
authors.initials: K
authors.lastname: Matsuda
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Inoue
authors.forename: Shigeki
authors.initials: S
authors.lastname: Kuriyama
mesh_terms: D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors; D048909:Diabetes Complications; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D015154:Esophageal Motility Disorders; D050782:Esophageal pH Monitoring; D005764:Gastroesophageal Reflux / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology; D006801:Humans
chemical_list: D004791:Enzyme Inhibitors; D000449:Aldehyde Reductase