title: Linezolid-induced posterior reversible leukoencephalopathy syndrome.
abstract: OBJECTIVE
  To describe a 71-year-old woman who developed clinical and neuroradiological features of posterior reversible leukoencephalopathy syndrome with a compromised blood-brain barrier after 5 days of intravenous linezolid therapy for an infected hip prosthesis.
  
  
  METHODS
  Case report.
  
  
  METHODS
  Academic research.
  
  
  METHODS
  Posterior reversible leukoencephalopathy syndrome was documented using serial cranial magnetic resonance imaging, and the blood-brain barrier disturbance was demonstrated by contrast enhancement of a lesion and by cerebrospinal fluid analysis.
  
  
  RESULTS
  Other causes of posterior reversible leukoencephalopathy syndrome, such as renal failure, severe hypertension, inflammatory syndromes, and infectious diseases of the central nervous system, were excluded during hospitalization. After discontinuation of linezolid therapy, the patient's condition improved rapidly.
  
  
  CONCLUSIONS
  To our knowledge, this is the first report of likely linezolid-induced posterior reversible leukoencephalopathy syndrome with an altered blood-brain barrier after short-term intravenous therapy.
authors.affiliation: Department of Neurology, University of Heidelberg, Heidelberg, Germany. simon.nagel@med.uni-heidleberg.de
authors.forename: Simon
authors.initials: S
authors.lastname: Nagel
authors.forename: Martin
authors.initials: M
authors.lastname: Köhrmann
authors.forename: Hagen B
authors.initials: HB
authors.lastname: Huttner
authors.forename: Brigitte
authors.initials: B
authors.lastname: Storch-Hagenlocher
authors.forename: Stefan
authors.initials: S
authors.lastname: Schwab
mesh_terms: D000081:Acetamides / Q000009:adverse effects*; D000368:Aged; D000890:Anti-Infective Agents / Q000009:adverse effects*; D001812:Blood-Brain Barrier / Q000187:drug effects / Q000503:physiopathology; D001927:Brain Diseases / Q000139:chemically induced* / Q000473:pathology; D005260:Female; D006801:Humans; D020343:Hypertensive Encephalopathy / Q000139:chemically induced / Q000473:pathology; D007239:Infections / Q000188:drug therapy; D000069349:Linezolid; D008279:Magnetic Resonance Imaging / Q000379:methods; D023303:Oxazolidinones / Q000009:adverse effects*
chemical_list: D000081:Acetamides; D000890:Anti-Infective Agents; D023303:Oxazolidinones; D000069349:Linezolid