title: [Impact of bacterial lectin on functional activity of lymphocytes].
abstract: Impact of Azospirillum brasilense Sp7 lectin with carbohydrate specificity to L-fucose on T- and B-lymphocytes production, activity of IL-1alpha, and TNF-alpha was studied in vitro and compared with influence of red kidney bean phytohemagglutinin (PHA) on the same parameters. Increase of growth of T- and B-cells subpopulations has been shown that point to stimulatory effect of the bacterial lectin. Bacterial lectin of A. brasilense also increased synthesis of IL-1alpha and TNF-alpha. It has been shown that the bacterial lectin has more pronounced stimulatory effect on functional activity of lymphocytes compared with PHA.
authors.forename: E G
authors.initials: EG
authors.lastname: Ponomareva
authors.forename: N V
authors.initials: NV
authors.lastname: Emel'ianova
authors.forename: V E
authors.initials: VE
authors.lastname: Nikitina
authors.forename: N B
authors.initials: NB
authors.lastname: Zakharova
mesh_terms: D015806:Azospirillum brasilense; D001402:B-Lymphocytes / Q000187:drug effects / Q000276:immunology; D002455:Cell Division; D002478:Cells, Cultured; D006801:Humans; D053582:Interleukin-1alpha / Q000096:biosynthesis; D037102:Lectins / Q000302:isolation & purification / Q000494:pharmacology*; D008214:Lymphocytes / Q000166:cytology / Q000187:drug effects* / Q000276:immunology; D010835:Phytohemagglutinins / Q000494:pharmacology; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000187:drug effects / Q000276:immunology
chemical_list: D053582:Interleukin-1alpha; D037102:Lectins; D010835:Phytohemagglutinins; D014409:Tumor Necrosis Factor-alpha