title: Alboatisins A-C, ent-atisene diterpenoids from Isodon albopilosus.
abstract: Three biogenetically interesting ent-kaurane-derived metabolites, alboatisins A-C (1-3), featuring a C-13-oxygenated ent-atisane skeleton, have been isolated from the aerial parts of Isodon albopilosus. Their structures were determined on the basis of spectroscopic evidence. Compound 2 exhibited cytotoxicity against A549 and HT-29 human cancer cells, with IC50 values of 8.3 and 7.9 microM, respectively.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.
authors.forename: Sheng-Xiong
authors.initials: SX
authors.lastname: Huang
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhou
authors.forename: Li-Bin
authors.initials: LB
authors.lastname: Yang
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhao
authors.forename: Sheng-Hong
authors.initials: SH
authors.lastname: Li
authors.forename: Li-Guang
authors.initials: LG
authors.lastname: Lou
authors.forename: Quan-Bin
authors.initials: QB
authors.lastname: Han
authors.forename: Li-Sheng
authors.initials: LS
authors.lastname: Ding
authors.forename: Han-Dong
authors.initials: HD
authors.lastname: Sun
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D037602:Isodon / Q000737:chemistry*; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D004365:Drugs, Chinese Herbal; C521649:alboatisin A; C521650:alboatisin B; C521651:alboatisin C