title: A three-dimensional model of fluid-structural interactions for quantifying the contractile force for cardiomyocytes on hybrid biopolymer microcantilever.
abstract: Quantitatively analysis of the contractility of cardiomyocytes is important for understanding the mechanism of heart failure as well as the molecular alterations in diseased heart cells. This paper presents a realistic computational model, which considers the three-dimensional fluid-structural interactions (FSI), to quantify the contractile force of cardiomyocytes on hybrid biopolymer microcantilevers. Prior to this study, only static modeling of the microscale cellular force has been reported. This study modeled the dynamics of cardiomyocytes on microcantilevers in a medium using the FSI. This realistic model was compared with static finite element modeling (FEM) analysis and the Stoney's equation-based analytical solution, and was validated by the deflections of the microcantilevers in the experimental results. Using harmonic response analysis in FSI modeling, the motion of a hybrid biopolymer microcantilever in the medium was identified as a second-order system and the influence of the dynamics of cardiomyocytes could be evaluated quantitatively.
authors.affiliation: Whitaker Institute for Biomedical Engineering, Johns Hopkins University, 3400 N. Charles Street, Baltimore, MD 21218, USA. sortpark@gmail.com
authors.forename: Jungyul
authors.initials: J
authors.lastname: Park
authors.forename: Suk-Kyu
authors.initials: SK
authors.lastname: Ryu
authors.forename: Jinseok
authors.initials: J
authors.lastname: Kim
authors.forename: Junghun
authors.initials: J
authors.lastname: Cha
authors.forename: Jeongeun
authors.initials: J
authors.lastname: Baek
authors.forename: Sukho
authors.initials: S
authors.lastname: Park
authors.forename: Byungkyu
authors.initials: B
authors.lastname: Kim
authors.forename: Sang Ho
authors.initials: SH
authors.lastname: Lee
mesh_terms: D001704:Biopolymers; D003198:Computer Simulation; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008954:Models, Biological; D009200:Myocardial Contraction / Q000502:physiology*; D032383:Myocytes, Cardiac / Q000166:cytology* / Q000502:physiology*
chemical_list: D001704:Biopolymers