Divergent microsatellite evolution in the human and chimpanzee lineages.
Comparison of the complete human genome sequence to one of its closest relatives, the chimpanzee genome, provides a unique opportunity for exploring recent evolutionary events affecting the microsatellites in these species. A simple assumption on microsatellite distribution is that the total length of perfect repeats is constant compared to that of imperfect ones regardless of the repeat sequence. In this paper, we show that this is valid for most of the chimpanzee genome but not for a number of human chromosomes. Our results suggest accelerated evolution of microsatellites in the human genome relative to the chimpanzee lineage.
Gáspári
Zoltán
Z
Institute of Chemistry, Eötvös Loránd University, Pázmány Péter sétány 1/A, H-1117 Budapest, Hungary.
Ortutay
Csaba
C
Tóth
Gábor
G
D000818:Animals; D001483:Base Sequence; D002875:Chromosomes; D002877:Chromosomes, Human; D019143:Evolution, Molecular; D014644:Genetic Variation; D005826:Genetics, Medical; D015894:Genome, Human; D006801:Humans; D018895:Microsatellite Repeats / Q000235:genetics*; D008969:Molecular Sequence Data; D002679:Pan troglodytes / Q000235:genetics*; D012091:Repetitive Sequences, Nucleic Acid; D018911:Trinucleotide Repeats