title: Synthesis of amides of 5-arylidene-2,4-dioxothiazolidine-3-acetic acid with 1,2,4-triazole system.
abstract: In the reaction of 5-arylidene-2,4-dioxothiazolidine-3-acetic acid chloride with 1,2,4-triazole, 1,2,4-triazoline-5-one and 1,2,4-triazoline-5-thione, the new corresponding 5-arylidene-2,4-dioxothiazolidine-3-acetic acid amides (5-16) were obtained. Compounds 6, 14 i 15 were investigated in vitro for their antioxidant activity.
authors.affiliation: Department of Organic Chemistry, Faculty of Pharmacy, Lublin Medical University, 6 Staszica Str., 20-081 Lublin, Poland.
authors.forename: Nazar
authors.initials: N
authors.lastname: Trotsko
authors.forename: Maria
authors.initials: M
authors.lastname: Dobosz
authors.forename: Victor
authors.initials: V
authors.lastname: Lukianchuk
mesh_terms: D000975:Antioxidants / Q000138:chemical synthesis* / Q000494:pharmacology*; D002855:Chromatography, Thin Layer; D007202:Indicators and Reagents; D015227:Lipid Peroxidation / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D045162:Thiazolidinediones / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D007202:Indicators and Reagents; D045162:Thiazolidinediones