Evaluation of the macroscopic growth degree of experimental endometriosis in rats.
OBJECTIVE
To evaluate macroscopically the growth degree of self-transplantation of endometriosis in rats.


METHODS
Forty female rats, after a 7-day period for adpating and evaluating of the estrous cycle regularity, underwent tail abdominal midline laparotomy with 3-cm cuts. The average third of the left uterine horn was removed, 4mm x 4mm patches in liquid environment were made, and self-transplanted in the rat mesenterium with a single stitch, and the endometrial surface of the endometriotic implant facing the lumen of the peritoneal cavity. The rats were programmed to die after three weeks. The abdominal cavity displaying was held and self-transplants were identified and classified.


RESULTS
The results achieved were: one case for degree 0 (2,5%), three cases for degree 1 (7,5%), eleven cases for degree II (27,5%) and twenty-five cases for degree III (62,5%).


CONCLUSIONS
The experimental endometriosis development, through the self-transplantation technique, showed to be most common in degrees 3 and 2 of development.
Nogueira Neto
João
J
Federal University of Maranhão, Mirage of the Sun Street 19, 1001 Renaissance II, 65075-760 São Luís, Maranhão, Brazil. j.nogueira.n@uol.com.br
Torres
Orlando Jorge Martins
OJ
Coelho
Tarcísio Mota
TM
Nunes
Joel Nicolau Nogueira
JN
Aguiar
Guilherme Carneiro
GC
Costa
Lícia Kércia de Araújo
LK
D000818:Animals; D004195:Disease Models, Animal; D004715:Endometriosis / Q000209:etiology / Q000473:pathology*; D004717:Endometrium / Q000166:cytology / Q000637:transplantation; D005260:Female; D051381:Rats; D017208:Rats, Wistar; D014182:Transplantation, Autologous; D014599:Uterus / Q000637:transplantation*