title: Quantification of reduced health-related quality of life in patients with rheumatoid arthritis compared to the general population.
abstract: OBJECTIVE
  To compare levels of health-related quality of life (HRQOL) among patients with rheumatoid arthritis (RA) to those of the general population.
  
  
  METHODS
  Disease burden was assessed using a generic health status instrument (Medical Outcome Study Short Form-36) for measurements of HRQOL and SF-6D to calculate utility scores in representative patients aged 20 to 79 years from the Oslo RA Register (n = 1052), and in individuals in the general population (n = 2323). Comparisons were performed with respect to sex and age, and standardized difference scores (s-scores) were calculated for comparisons with the norm.
  
  
  RESULTS
  HRQOL in patients with RA was reduced compared to the general population on all scales of the SF-36 for both males and females and for all age groups. s-scores adjusted for age and education ranged from -1.39 for physical functioning to -0.27 for mental health. The overall difference in utility was 0.16 and ranged from 0.13 (in female patients below 50 yrs) to 0.20 (patients 50-60 years). This implies that RA of 1 year duration entails a disease burden of 14-20 quality-adjusted life-years in 100 RA patients.
  
  
  CONCLUSIONS
  RA inflicts a substantial disease burden, and the disease affects all HRQOL dimensions as measured by the SF-36 in both sexes and in all age groups. Physical functioning is predominantly affected, but RA has social and mental consequences.
authors.affiliation: Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway. till.uhlig@nrrk.no
authors.forename: Till
authors.initials: T
authors.lastname: Uhlig
authors.forename: Jon H
authors.initials: JH
authors.lastname: Loge
authors.forename: Ivar S
authors.initials: IS
authors.lastname: Kristiansen
authors.forename: Tore K
authors.initials: TK
authors.lastname: Kvien
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000150:complications / Q000503:physiopathology* / Q000523:psychology*; D016022:Case-Control Studies; D017281:Cost of Illness; D004185:Disability Evaluation; D005260:Female; D006305:Health Status Indicators; D006801:Humans; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D019057:Quality-Adjusted Life Years; D012042:Registries; D012720:Severity of Illness Index; D012737:Sex Factors; D018434:Sickness Impact Profile