title: Matrices and scaffolds for drug delivery in dental, oral and craniofacial tissue engineering.
abstract: Current treatments for diseases and trauma of dental, oral and craniofacial (DOC) structures rely on durable materials such as amalgam and synthetic materials, or autologous tissue grafts. A paradigm shift has taken place to utilize tissue engineering and drug delivery approaches towards the regeneration of these structures. Several prototypes of DOC structures have been regenerated such as temporomandibular joint (TMJ) condyle, cranial sutures, tooth structures and periodontium components. However, many challenges remain when taking in consideration the high demand for esthetics of DOC structures, the complex environment and yet minimal scar formation in the oral cavity, and the need for accommodating multiple tissue phenotypes. This review highlights recent advances in the regeneration of DOC structures, including the tooth, periodontium, TMJ, cranial sutures and implant dentistry, with specific emphasis on controlled release of signaling cues for stem cells, biomaterial matrices and scaffolds, and integrated tissue engineering approaches.
authors.affiliation: Columbia University, Tissue Engineering and Regenerative Medicine Laboratory (TERML), College of Dental Medicine, Fu Foundation School of Engineering and Applied Sciences, Department of Biomedical Engineering, New York, NY 10032, USA.
authors.forename: Eduardo K
authors.initials: EK
authors.lastname: Moioli
authors.forename: Paul A
authors.initials: PA
authors.lastname: Clark
authors.forename: Xuejun
authors.initials: X
authors.lastname: Xin
authors.forename: Shan
authors.initials: S
authors.lastname: Lal
authors.forename: Jeremy J
authors.initials: JJ
authors.lastname: Mao
mesh_terms: D001672:Biocompatible Materials; D019465:Craniofacial Abnormalities / Q000628:therapy*; D003757:Dental Implantation / Q000379:methods* / Q000639:trends; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000008:administration & dosage* / Q000627:therapeutic use; D010510:Periodontal Diseases / Q000628:therapy*; D012038:Regeneration / Q000502:physiology*; D013704:Temporomandibular Joint / Q000187:drug effects / Q000502:physiology*; D023822:Tissue Engineering / Q000379:methods* / Q000639:trends; D014076:Tooth Diseases / Q000628:therapy*
chemical_list: D001672:Biocompatible Materials; D036341:Intercellular Signaling Peptides and Proteins