Pharmacological, surgical, and neurovascular interventions to augment acute aphasia recovery.
Aphasia recovery has often been attributed to a combination of "spontaneous recovery" and rehabilitation. However, a variety of new pharmacological, surgical, and interventional neuroradiology procedures have been developed that can complement rehabilitation in the first days to weeks after stroke by restoring blood flow to dysfunctional but salvageable brain tissue. This paper will review the medical and surgical interventions to improve regional cerebral blood flow that recently have been shown to (1) augment aphasia recovery by improving tissue function, and (2) prevent expansion of the stroke that would otherwise impede recovery. Success with such treatments facilitates aphasia rehabilitation by improving the baseline language performance that must be improved further with language therapy.
Hillis
Argye E
AE
Department of Neurology and Department of Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Baltimore, MD 21287, USA.
D001037:Aphasia / Q000188:drug therapy / Q000534:rehabilitation* / Q000601:surgery; D001794:Blood Pressure; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D002800:Cholinesterase Inhibitors / Q000627:therapeutic use*; D016894:Endarterectomy, Carotid; D006801:Humans; D015607:Stents; D000071939:Stroke Rehabilitation
D002800:Cholinesterase Inhibitors