title: Current role of LC-MS in therapeutic drug monitoring.
abstract: The role of liquid chromatography coupled with mass spectrometry (LC-MS) techniques in routine therapeutic drug monitoring activity is becoming increasingly important. This paper reviews LC-MS methods published in the last few years for certain classes of drugs subject to therapeutic drug monitoring: immunosuppressants, antifungal drugs, antiretroviral drugs, antidepressants and antipsychotics. For each class of compounds, we focussed on the most interesting methods and evaluated the current role of LC-MS in therapeutic drug monitoring.
authors.affiliation: Department of Pharmacology-Toxicology, Limoges University Hospital, Unité INSERM U850, 87042 Limoges cedex, France.
authors.forename: Franck
authors.initials: F
authors.lastname: Saint-Marcoux
authors.forename: François-Ludovic
authors.initials: FL
authors.lastname: Sauvage
authors.forename: Pierre
authors.initials: P
authors.lastname: Marquet
mesh_terms: D002853:Chromatography, Liquid; D016903:Drug Monitoring / Q000379:methods*; D006801:Humans; D013058:Mass Spectrometry; D004364:Pharmaceutical Preparations / Q000032:analysis
chemical_list: D004364:Pharmaceutical Preparations