Lyme neuroborreliosis: infection, immunity, and inflammation.
Lyme neuroborreliosis (LNB), the neurological manifestation of systemic infection with the complex spirochaete Borrelia burgdorferi, can pose a challenge for practising neurologists. This Review is a summary of clinical presentation, diagnosis, and therapy, as well as of recent advances in our understanding of LNB. Many new insights have been gained through work in experimental models of the disease. An appreciation of the genetic heterogeneity of the causative pathogen has helped clinicians in their understanding of the diverse presentations of LNB.
Pachner
Andrew R
AR
Department of Neurosciences, UMDNJ-New Jersey Medical School, Newark, NJ 07103, USA. pachner@umdnj.edu
Steiner
Israel
I
D000818:Animals; D001898:Borrelia / Q000472:pathogenicity*; D006801:Humans; D007109:Immunity; D007239:Infections / Q000150:complications*; D007249:Inflammation; D022123:Lyme Disease Vaccines; D020852:Lyme Neuroborreliosis / Q000150:complications* / Q000453:epidemiology / Q000209:etiology*
D022123:Lyme Disease Vaccines