A neuropsychological profile of off-diet adults with phenylketonuria.
The metabolic disorder phenylketonuria (PKU) is treated early by a low-phenylalanine diet. While this prevents global cognitive impairment, some patients still experience cognitive and neurophysiological abnormalities. Neuropsychological testing of early treated, currently off-diet, PKU patients attending an adult PKU clinic showed a reduction in the Perceptual Organization Index (POI), Processing Speed Index (PSI) from the Wechsler Adult Intelligence Scale Third Edition (WAIS-III), and Part A of the Trail Making Test for the PKU group relative to controls. Taken together, these results supported a profile of reduced information-processing speed.
Moyle
J J
JJ
School of Psychology, The University of Western Australia, Perth, WA, Australia. jmoyle@student.uwa.edu.au
Fox
A M
AM
Bynevelt
M
M
Arthur
M
M
Burnett
J R
JR
D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D010649:Phenylalanine / Q000008:administration & dosage; D010661:Phenylketonurias / Q000178:diet therapy* / Q000503:physiopathology*; D011340:Problem Solving / Q000502:physiology; D014888:Wechsler Scales
D010649:Phenylalanine