title: [1,3]Diazaheterofused isoindolol derivatives displaying anxiolytic-like effects on mice.
abstract: Anxiolytic-like effects induced on mice by several compounds with imidazo[2,1-a]isoindolol (II), pyrimido[2,1-a]isoindolol (III) and [1,3]diazepino[2,1-a]isoindolol (IV) structures have been evaluated through the elevated plus-maze test. The evaluation has been based on measuring the spent time and counting the number of entries of mice in the open arms of the maze. Single intraperitoneal administration of imidazoisoindolol IIe and pyrimidoisoindolols IIIa, IIIe and IIIg induced significant increments in these behavioural parameters.
authors.affiliation: Departamento de Química Farmacéutica, Facultad de Farmacia, Campus Unamuno, 37007-Salamanca, Spain.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Zamilpa
authors.forename: Maribel
authors.initials: M
authors.lastname: Herrera-Ruiz
authors.forename: Esther
authors.initials: E
authors.lastname: Del Olmo
authors.forename: José L
authors.initials: JL
authors.lastname: López-Pérez
authors.forename: Jaime
authors.initials: J
authors.lastname: Tortoriello
authors.forename: Arturo
authors.initials: A
authors.lastname: San Feliciano
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000737:chemistry / Q000494:pharmacology*; D007211:Indoles / Q000737:chemistry / Q000494:pharmacology*; D018782:Maze Learning; D051379:Mice; D008958:Models, Molecular; D013329:Structure-Activity Relationship
chemical_list: D014151:Anti-Anxiety Agents; D007211:Indoles