title: Three synchronized neoplasms of the female genital tract: an extraordinary presentation.
abstract: BACKGROUND
  We report a case of unusual co-existence of multiple primary neoplasms of female genital tract.
  
  
  METHODS
  A 62-year-old gravida 2, para 2 was referred with spotting and vaginal discharge for about 6 months. Fractionate curettage was performed and documented endocervical squamous cell carcinoma in situ. Subsequently total abdominal hysterectomy and bilateral salphingo-oophorectomy was performed. Final pathological report demonstrated cervical squamous cell carcinoma, right ovarian Brenner tumor, left ovarian granulosa tumor and endometrial polyps.
  
  
  CONCLUSIONS
  Multiple primary neoplasms of female genital tract is a well-recognized yet rare occurrence. Although the presented case is probably an incidental event, the pathogenesis of the neoplastic process affecting the tissues with different embryological origin needs further research and evaluation. It is important to distinguish multiple primary neoplasms from metastatic disease because of the fact that overall survival as well as treatment would vary considerably.
authors.affiliation: Obstetrics and Gynecology Department, Marmara Univestiy, Istanbul, Turkey.
authors.forename: Tanju
authors.initials: T
authors.lastname: Pekin
authors.forename: Pinar
authors.initials: P
authors.lastname: Yoruk
authors.forename: Recep
authors.initials: R
authors.lastname: Yildizhan
authors.forename: Begüm
authors.initials: B
authors.lastname: Yildizhan
authors.forename: Saime
authors.initials: S
authors.lastname: Ramadan
mesh_terms: D001948:Brenner Tumor / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D003937:Diagnosis, Differential; D016889:Endometrial Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D005187:Fallopian Tubes / Q000601:surgery; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D010052:Ovariectomy; D011127:Polyps / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery