title: High-speed 3T MR spectroscopic imaging of prostate with flyback echo-planar encoding.
abstract: Prostate MR spectroscopic imaging (MRSI) at 3T may provide two-fold higher spatial resolution over 1.5T, but this can result in longer acquisition times to cover the entire gland using conventional phase-encoding. In this study, flyback echo-planar readout trajectories were incorporated into a Malcolm Levitt's composite-pulse decoupling sequence (MLEV)-point-resolved spectroscopy sequence (PRESS) to accelerate the acquisition of large array (16 x 16 x 8), high spatial (0.154 cm(3)) resolution MRSI data by eight-fold to just 8.5 minutes. Artifact free, high-quality MRSI data was obtained in nine prostate cancer patients. Easy data reconstruction and the robustness of the flyback echo-planar encoding make this technique particularly suitable for the clinical setting. The short acquisition time provided by this method reduces the 3T prostate MRI/MRSI exam time, allows longer repetition times, and/or allows the acquisition of additional MR acquisitions within the same exam.
authors.affiliation: Department of Radiology, University of California at San Francisco, San Francisco, CA 94143, USA.
authors.forename: Albert P
authors.initials: AP
authors.lastname: Chen
authors.forename: Charles H
authors.initials: CH
authors.lastname: Cunningham
authors.forename: Esin
authors.initials: E
authors.lastname: Ozturk-Isik
authors.forename: Duan
authors.initials: D
authors.lastname: Xu
authors.forename: Ralph E
authors.initials: RE
authors.lastname: Hurd
authors.forename: Douglas A C
authors.initials: DA
authors.lastname: Kelley
authors.forename: John M
authors.initials: JM
authors.lastname: Pauly
authors.forename: John
authors.initials: J
authors.lastname: Kurhanewicz
authors.forename: Sarah J
authors.initials: SJ
authors.lastname: Nelson
authors.forename: Daniel B
authors.initials: DB
authors.lastname: Vigneron
mesh_terms: D000368:Aged; D016477:Artifacts; D017352:Echo-Planar Imaging / Q000379:methods*; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D007091:Image Processing, Computer-Assisted; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000473:pathology*