title: Synthesis and antibacterial activity of 3-keto-6-O-carbamoyl-11,12-cyclic thiocarbamate erythromycin A derivatives.
abstract: A series of 3-keto-6-O-carbamoyl-11,12-cyclic thiocarbamate erythromycin A derivatives has been synthesized. The best compounds in this series possess potent in vitro antibacterial activity against erythromycin-susceptible and erythromycin-resistant bacteria.
authors.affiliation: Research & Early Development, Johnson & Johnson Pharmaceutical Research & Development, L.L.C., 8 Clarke Drive, Cranbury, NJ 08512, USA. bzhu@prdus.jnj.com
authors.forename: Bin
authors.initials: B
authors.lastname: Zhu
authors.forename: Brett A
authors.initials: BA
authors.lastname: Marinelli
authors.forename: Darren
authors.initials: D
authors.lastname: Abbanat
authors.forename: Barbara D
authors.initials: BD
authors.lastname: Foleno
authors.forename: Karen
authors.initials: K
authors.lastname: Bush
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Macielag
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D004917:Erythromycin / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D013211:Staphylococcus aureus / Q000187:drug effects; D013296:Streptococcus pneumoniae / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D004917:Erythromycin