[Properties of live antibiotics-resistant anthrax vaccine STI-PR after long-term storage].
Study showed that cultural, morphologic, genetic, immunologic characteristics, and resistance to antibiotics of STI-PR anthrax vaccine did not change after storage during 20 years in lyophilized condition. It has been shown that medium for lyophilization plays important role in preservation of vitality of anthrax spores. Optimal preservative properties have been observed for thioureal and sucrose-gelatinous media for lyophilization. Obtained results give reasons for prolongation of shelf live of STI-PR vaccine from 2 - 3 to 5 - 8 years.
Aksenova
L Iu
LIu
Buravtseva
N P
NP
Kogotkova
O I
OI
Eremenko
E I
EI
Tsygankova
O I
OI
D000818:Animals; D000881:Anthrax / Q000276:immunology / Q000517:prevention & control; D022122:Anthrax Vaccines / Q000592:standards* / Q000633:toxicity; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000942:Antigens, Bacterial / Q000235:genetics; D001408:Bacillus anthracis / Q000187:drug effects* / Q000502:physiology*; D001427:Bacterial Toxins / Q000235:genetics; D024901:Drug Resistance, Multiple, Bacterial; D004356:Drug Storage / Q000379:methods / Q000592:standards; D005612:Freeze Drying / Q000379:methods; D005780:Gelatin; D005798:Genes, Bacterial / Q000235:genetics; D006168:Guinea Pigs; D007114:Immunization; D007928:Lethal Dose 50; D016133:Polymerase Chain Reaction; D013171:Spores, Bacterial / Q000254:growth & development; D013395:Sucrose; D013890:Thiourea; D013997:Time Factors; D014774:Virulence
D022122:Anthrax Vaccines; D000900:Anti-Bacterial Agents; D000942:Antigens, Bacterial; D001427:Bacterial Toxins; C030325:anthrax toxin; D013395:Sucrose; D005780:Gelatin; D013890:Thiourea