title: Association study of Toll-like receptor 5 (TLR5) and Toll-like receptor 9 (TLR9) polymorphisms in systemic lupus erythematosus.
abstract: OBJECTIVE
  Toll-like receptors (TLR) play an important role in both adaptive and innate immunity. Variations in TLR genes have been shown to be associated with various infectious and inflammatory diseases. We investigated the association of TLR5 (Arg392Stop, rs5744168) and TLR9 (-1237T-->C, rs5743836) single nucleotide polymorphisms (SNP) with systemic lupus erythematosus (SLE) in Caucasian American subjects.
  
  
  METHODS
  We performed a case-control association study and genotyped 409 Caucasian women with SLE and 509 Caucasian healthy female controls using TaqMan allelic discrimination (rs5744168) or polymerase chain reaction-restriction fragment length polymorphism analysis (rs5743836).
  
  
  RESULTS
  None of the 2 TLR SNP showed a statistically significant association with SLE risk in our cohort.
  
  
  CONCLUSIONS
  Our results do not indicate a major influence of these putative functional TLR SNP on the susceptibility to (or protection from) SLE.
authors.affiliation: Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA.
authors.forename: F Yesim K
authors.initials: FY
authors.lastname: Demirci
authors.forename: Susan
authors.initials: S
authors.lastname: Manzi
authors.forename: Rosalind
authors.initials: R
authors.lastname: Ramsey-Goldman
authors.forename: Margaret
authors.initials: M
authors.lastname: Kenney
authors.forename: Penny S
authors.initials: PS
authors.lastname: Shaw
authors.forename: Charmayne M
authors.initials: CM
authors.lastname: Dunlop-Thomas
authors.forename: Amy H
authors.initials: AH
authors.lastname: Kao
authors.forename: Elisa Y
authors.initials: EY
authors.lastname: Rhew
authors.forename: Franklin
authors.initials: F
authors.lastname: Bontempo
authors.forename: Candace
authors.initials: C
authors.lastname: Kammerer
authors.forename: M Ilyas
authors.initials: MI
authors.lastname: Kamboh
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D051198:Toll-Like Receptor 5 / Q000235:genetics*; D051217:Toll-Like Receptor 9 / Q000235:genetics*; D044465:White People / Q000235:genetics
chemical_list: D051198:Toll-Like Receptor 5; D051217:Toll-Like Receptor 9