title: WHO HIV clinical staging or CD4 cell counts for antiretroviral therapy eligibility assessment? An evaluation in rural Rakai district, Uganda.
abstract: The ability of WHO clinical staging to predict CD4 cell counts of 200 cells/microl or less was evaluated among 1221 patients screened for antiretroviral therapy (ART). Sensitivity was 51% and specificity was 88%. The positive predictive value was 64% and the negative predictive value was 81%. Clinical criteria missed half the patients with CD4 cell counts of 200 cells/microl or less, highlighting the importance of CD4 cell measurements for the scale-up of ART provision in resource-limited settings.
authors.affiliation: Rakai Health Sciences Programme, Rakai, Uganda.
authors.forename: Joseph
authors.initials: J
authors.lastname: Kagaayi
authors.forename: Fredrick
authors.initials: F
authors.lastname: Makumbi
authors.forename: Gertrude
authors.initials: G
authors.lastname: Nakigozi
authors.forename: Maria J
authors.initials: MJ
authors.lastname: Wawer
authors.forename: Ronald H
authors.initials: RH
authors.lastname: Gray
authors.forename: David
authors.initials: D
authors.lastname: Serwadda
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Reynolds
mesh_terms: D044966:Anti-Retroviral Agents / Q000627:therapeutic use*; D018791:CD4 Lymphocyte Count / Q000379:methods*; D015658:HIV Infections / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology*; D006801:Humans; D012423:Rural Health; D012680:Sensitivity and Specificity; D014454:Uganda / Q000453:epidemiology
chemical_list: D044966:Anti-Retroviral Agents