title: Downregulation of the beta1,3- galactosyltransferase gene in tonsillar B lymphocytes and aberrant lectin bindings to tonsillar IgA as a pathogenesis of IgA nephropathy.
abstract: IgA is a glycoprotein with multiple O-glycans. Under-O-glycosylation of the hinge in IgA in patients with IgA nephropathy (IgAN) is reported. The development of IgAN is frequently preceded by episodes of upper respiratory tract infections such as tonsillitis. Therefore, the tonsils may be related to the pathogenesis of IgAN. However, the mechanism of underglycosylation in tonsillar IgA has not yet been fully elucidated. Since O-glycans in IgA are produced by glycosyltransferases, we hypothesized that dysregulation of the enzymes is associated with underglycosylation.
authors.affiliation: Departmentsof Medicine and Clinical Science Okayama University Graduate School of Medicine, Okayama, Japan.
authors.forename: Tatsuyuki
authors.initials: T
authors.lastname: Inoue
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Sugiyama
authors.forename: Yoko
authors.initials: Y
authors.lastname: Kikumoto
authors.forename: Naomi
authors.initials: N
authors.lastname: Fukuoka
authors.forename: Yohei
authors.initials: Y
authors.lastname: Maeshima
authors.forename: Hisashi
authors.initials: H
authors.lastname: Hattori
authors.forename: Kunihiro
authors.initials: K
authors.lastname: Fukushima
authors.forename: Kazunori
authors.initials: K
authors.lastname: Nishizaki
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Hiki
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Makino
mesh_terms: D001402:B-Lymphocytes / Q000201:enzymology* / Q000276:immunology; D001706:Biopsy; D015536:Down-Regulation / Q000276:immunology; D005700:Galactosyltransferases; D015971:Gene Expression Regulation, Enzymologic; D005922:Glomerulonephritis, IGA / Q000276:immunology* / Q000378:metabolism* / Q000473:pathology; D005964:Glucosyltransferases / Q000235:genetics* / Q000378:metabolism; D006031:Glycosylation; D006801:Humans; D007070:Immunoglobulin A / Q000276:immunology / Q000378:metabolism*; D037102:Lectins / Q000378:metabolism; D014066:Palatine Tonsil / Q000166:cytology* / Q000276:immunology
chemical_list: D007070:Immunoglobulin A; D037102:Lectins; C514116:B3GLCT protein, human; D005700:Galactosyltransferases; D005964:Glucosyltransferases