title: Is TGFBR1*6A a susceptibility allele for nonsyndromic familial colorectal neoplasia?
abstract: Our analysis definitely excludes the possibility of the TGFBR1*6A allele increasing the risk of colorectal neoplasia in our sample population. A recent study validating linkage of colorectal cancer to chromosome 9q also excluded the TGFBR1*6A allele as a disease-causing variant in that sample. We conclude that there remains an unidentified susceptibility locus in the region 9q22.2-31.2.
authors.affiliation: Department of Epidemiology, University Hospitals of Cleveland/Case Western Reserve University and Howard Hughes Medical Institute, and Cleveland, Ohio, USA. ddaley@mrl.ubc.ca
authors.forename: Denise
authors.initials: D
authors.lastname: Daley
authors.forename: Wendi
authors.initials: W
authors.lastname: Morgan
authors.forename: Susan
authors.initials: S
authors.lastname: Lewis
authors.forename: Joseph
authors.initials: J
authors.lastname: Willis
authors.forename: Robert C
authors.initials: RC
authors.lastname: Elston
authors.forename: Sanford D
authors.initials: SD
authors.lastname: Markowitz
authors.forename: Georgia L
authors.initials: GL
authors.lastname: Wiesner
mesh_terms: D000483:Alleles; D002899:Chromosomes, Human, Pair 9; D015179:Colorectal Neoplasms / Q000235:genetics*; D005190:Family; D005260:Female; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D017346:Protein Serine-Threonine Kinases / Q000235:genetics*; D000077293:Receptor, Transforming Growth Factor-beta Type I; D018125:Receptors, Transforming Growth Factor beta / Q000235:genetics*; D012044:Regression Analysis
chemical_list: D018125:Receptors, Transforming Growth Factor beta; D017346:Protein Serine-Threonine Kinases; D000077293:Receptor, Transforming Growth Factor-beta Type I; C000625841:TGFBR1 protein, human