Role of Peyer's patches in the induction of Helicobacter pylori-induced gastritis.
Helicobacter pylori is a Gram-negative spiral bacterium that causes gastritis and peptic ulcer and has been implicated in the pathogenesis of gastric adenocarcinoma and mucosa-associated lymphoid tissue lymphoma. Although Th1 immunity is involved in gastritis and the accumulation of H. pylori-specific CD4(+) T cells in the H. pylori-infected gastric mucosa in human patients, how T cells are primed with H. pylori antigens is unknown because no apparent lymphoid tissues are present in the stomach. We demonstrate here that Peyer's patches (PPs) in the small intestine play critical roles in H. pylori-induced gastritis; no gastritis is induced in H. pylori-infected mice lacking PPs. We also observed that the coccoid form of H. pylori is phagocytosed by dendritic cells in PPs. We propose that H. pylori converts to the coccoid form in the anaerobic small intestine and stimulates the host immune system through PPs.
Nagai
Shigenori
S
Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo 160-8582, Japan.
Mimuro
Hitomi
H
Yamada
Taketo
T
Baba
Yukiko
Y
Moro
Kazuyo
K
Nochi
Tomonori
T
Kiyono
Hiroshi
H
Suzuki
Toshihiko
T
Sasakawa
Chihiro
C
Koyasu
Shigeo
S
D019264:Adoptive Transfer / Q000009:adverse effects; D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D004268:DNA-Binding Proteins / Q000172:deficiency / Q000235:genetics / Q000378:metabolism; D003713:Dendritic Cells / Q000276:immunology; D005756:Gastritis / Q000276:immunology* / Q000382:microbiology* / Q000473:pathology; D016481:Helicobacter Infections / Q000276:immunology* / Q000382:microbiology / Q000473:pathology*; D016480:Helicobacter pylori / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D010581:Peyer's Patches / Q000276:immunology*; D010587:Phagocytosis
D000942:Antigens, Bacterial; D004268:DNA-Binding Proteins; C499308:Rag2 protein, mouse