title: The Allergic Rhinitis and its Impact on Asthma system: a new classification of allergic rhinitis and nasal responsiveness.
abstract: OBJECTIVE
  Allergic rhinitis has traditionally been classified into seasonal and perennial rhinitis. However, many subjects with dual sensitisation do not fit neatly into either category. Recently, the Allergic Rhinitis and its Impact on Asthma workshop has proposed a new allergic rhinitis classification, into intermittent and persistent forms. The purpose of the present study was to investigate whether the symptomatic and secretory responsiveness of allergic rhinitis sufferers correlated well with the Allergic Rhinitis and its Impact on Asthma classification, compared with the traditional classification.
  
  
  METHODS
  Experimental study.
  
  
  METHODS
  Forty subjects with allergic rhinitis and 13 normal controls underwent a unilateral nasal bradykinin challenge protocol. Symptom scores were recorded and secretion weights measured bilaterally using filter paper disks. The symptomatic and secretory responses of allergic subjects were analysed according to both the traditional and the Allergic Rhinitis and its Impact on Asthma classifications, and the two systems were compared.
  
  
  RESULTS
  For both classification systems, the two groups of allergic subjects were clearly demarcated by secretory responses. However, after classification according to the traditional system, there was a lack of clear demarcation between the groups as regards symptomatic response, whereas clear demarcation of symptomatic responses was seen after using the Allergic Rhinitis and its Impact on Asthma classification.
  
  
  CONCLUSIONS
  In allergic rhinitis subjects, the degree of nasal responsiveness was closely related to their Allergic Rhinitis and its Impact on Asthma classification. Furthermore, this classification was not compromised by the inclusion of subjects with dual sensitisation. Thus, the Allergic Rhinitis and its Impact on Asthma classification may have advantages for future research studies on allergic rhinitis.
authors.affiliation: Department of Otolaryngology, Royal College of Surgeons in Ireland and Beaumont Hospital, Dublin, Ireland. sheahanp@mskcc.org
authors.forename: P
authors.initials: P
authors.lastname: Sheahan
authors.forename: R
authors.initials: R
authors.lastname: McConn-Walsh
authors.forename: M
authors.initials: M
authors.lastname: Walsh
authors.forename: R W
authors.initials: RW
authors.lastname: Costello
mesh_terms: D001249:Asthma / Q000150:complications; D001920:Bradykinin; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D009299:Nasal Provocation Tests / Q000379:methods; D012221:Rhinitis, Allergic, Perennial / Q000145:classification*; D012882:Skin Tests / Q000379:methods; D016896:Treatment Outcome; D014665:Vasodilator Agents
chemical_list: D014665:Vasodilator Agents; D001920:Bradykinin