Dynamic modeling for shear stress induced ATP release from vascular endothelial cells.
A dynamic model is proposed for shear stress induced adenosine triphosphate (ATP) release from endothelial cells (ECs). The dynamic behavior of the ATP/ADP concentration at the endothelial surface by viscous shear flow is investigated through simulation studies based on the dynamic ATP release model. The numerical results demonstrate that the ATP/ADP concentration against time at endothelium-fluid interface predicted by the dynamic ATP release model is more consistent with the experimental observations than that predicted by previous static ATP release model.
Qin
Kai Rong
KR
Institute of Mechanobiology and Medical Engineering, Shanghai Jiao Tong University, Mailbox 888, 800 Dongchuan Road, Minhang, Shanghai 200240, China. krqin@sjtu.edu.cn
Xiang
Cheng
C
Xu
Zhe
Z
Cao
Ling Ling
LL
Ge
Shuzhi Sam
SS
Jiang
Zong Lai
ZL
D000244:Adenosine Diphosphate / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism*; D000818:Animals; D002478:Cells, Cultured; D003198:Computer Simulation; D042783:Endothelial Cells / Q000378:metabolism*; D004730:Endothelium, Vascular / Q000166:cytology / Q000378:metabolism; D006801:Humans; D007700:Kinetics; D008955:Models, Cardiovascular; D011673:Pulsatile Flow; D018048:Receptors, Purinergic P2 / Q000378:metabolism; D013314:Stress, Mechanical; D014783:Viscosity
D018048:Receptors, Purinergic P2; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate