title: [Clinical and immunological characteristics of rubella in western Siberia].
abstract: Evaluations of immune system of 155 patients with rubella and 90 contacts with patients were examined. Detection of viral genetic material in blood, urine, and nasopharyngeal swabs has been performed using RT-PCR method. Clinical diagnosis has been confirmed by RT-PCR in 114 (73.5%) patients. Changes of laboratory tests for rubella without clinical signs of the infection were observed in 20% of contacts. Complex ELISA- and PCR-assisted examination of patients can help to determine the stage of disease and characteristics of immune response. For differential diagnostic of rubella and other infectious diseases with exanthema it is rational to perform complex examination of patients using immunologic and molecular biologic methods.
authors.forename: E M
authors.initials: EM
authors.lastname: Malkova
authors.forename: I D
authors.initials: ID
authors.lastname: Petrova
authors.forename: M A
authors.initials: MA
authors.lastname: Smerdova
authors.forename: A S
authors.initials: AS
authors.lastname: Obert
authors.forename: A P
authors.initials: AP
authors.lastname: Pomogaeva
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Minakova
authors.forename: S Iu
authors.initials: SIu
authors.lastname: Iur'ev
authors.forename: A V
authors.initials: AV
authors.lastname: Krasnov
authors.forename: Z A
authors.initials: ZA
authors.lastname: Khokhlova
authors.forename: E A
authors.initials: EA
authors.lastname: Golubina
authors.forename: L I
authors.initials: LI
authors.lastname: Zinov'eva
authors.forename: O M
authors.initials: OM
authors.lastname: Krasman
authors.forename: E N
authors.initials: EN
authors.lastname: Ustinova
authors.forename: G I
authors.initials: GI
authors.lastname: Tiunnikov
authors.forename: L N
authors.initials: LN
authors.lastname: Iashina
authors.forename: S V
authors.initials: SV
authors.lastname: Netesov
authors.forename: V S
authors.initials: VS
authors.lastname: Petrov
mesh_terms: D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000097:blood* / Q000276:immunology; D000915:Antibody Affinity; D002353:Carrier State / Q000175:diagnosis / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D018450:Disease Progression; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D012367:RNA, Viral / Q000032:analysis; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012409:Rubella / Q000175:diagnosis / Q000276:immunology* / Q000821:virology; D012412:Rubella virus / Q000235:genetics / Q000276:immunology* / Q000302:isolation & purification; D012800:Siberia
chemical_list: D000914:Antibodies, Viral; D012367:RNA, Viral