[Recent advances in the applications of ultrasonic microbubbles as gene delivery systems].
Ultrasonic beam can be focused on a particular tissue. As ultrasound contrast agents for medical ultrasound imaging, gas-filled microbubbles can also be used as drugs or gene carriers. Therefore, ultrasonic microbubbles become a topic of intense interest in drug delivery because they can be used as gene targeting delivery systems. Based on the relevant materials, the applications of ultrasonic microbubbles as gene delivery systems in various tissues in vivo were reviewed, such as cardiac, vascular, skeletal muscle and tumor. Their potential problems in future use were also discussed.
Zhao
Ying-zheng
YZ
Department of Clinical Pharmacology, General Hospital of Beijing Command of PLA, Beijing 100700, China. lctuua@yahoo.com.cn
Lu
Cui-tao
CT
D000818:Animals; D003110:Colonic Neoplasms / Q000628:therapy; D003327:Coronary Disease / Q000628:therapy; D016503:Drug Delivery Systems / Q000295:instrumentation / Q000379:methods* / Q000639:trends; D015316:Genetic Therapy / Q000295:instrumentation / Q000379:methods* / Q000639:trends; D006801:Humans; D008055:Lipids / Q000737:chemistry; D045423:Microbubbles; D014465:Ultrasonics
D008055:Lipids