HLA alleles as predisposal factors for postmenopausal osteoporosis in a Greek population.
It is well established that genetic factors play an important role in the pathogenesis of osteoporosis, a common condition characterized by reduced bone mass and increased fracture risk. The major histocompatibility complex in humans, known as human leukocyte antigen (HLA) region, is the most polymorphic human genetic system and it is known as a cluster of genetic markers, associated with several diseases. In order to evaluate the contribution of HLA alleles in bone mass loss, polymorphisms in the HLA class I (-A, -B and -Cw) and class II (-DR and -DQ) antigens were studied in 126 postmenopausal women of Greek origin. It was found that HLA-B7 (P= 0.069), -DR15 (P= 0.019) and -DQ6 (P= 0.026) were associated with a lower bone mineral density measured at the forearm. This study shows a significant association between HLA alleles and bone mass loss in the population studied.
Douroudis
K
K
Department of Immunology and Histocompatibility, Evangelismos Hospital, Athens, Greece. drkmb@email.com
Tarassi
K
K
Athanassiades
T
T
Giannakopoulos
F
F
Kominakis
A
A
Thalassinos
N
N
Papasteriades
Ch
Ch
D000483:Alleles; D015519:Bone Density / Q000235:genetics; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D006115:Greece; D006680:HLA Antigens / Q000235:genetics*; D015793:HLA-B7 Antigen / Q000235:genetics; D006683:HLA-DQ Antigens / Q000235:genetics; D006684:HLA-DR Antigens / Q000235:genetics; D059810:HLA-DR Serological Subtypes; D006801:Humans; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000235:genetics* / Q000276:immunology* / Q000503:physiopathology; D012307:Risk Factors
D006680:HLA Antigens; D015793:HLA-B7 Antigen; D006683:HLA-DQ Antigens; C063831:HLA-DQ6 antigen; D006684:HLA-DR Antigens; D059810:HLA-DR Serological Subtypes; C106559:HLA-DR15 antigen