Cytotoxic activity of lignans from Hibiscus cannabinus.
The antimicrobial and cytotoxic activities of six lignans isolated from the core and bark acetone extracts of Hibiscus cannabinus have been investigated. Two compounds (2 and 3) showed strong cytotoxic activity against HeLa, Hep-2 and A-549 cell lines while compound 5 showed moderate activity on HeLa cells when they were in advanced stage of cellular division. The compounds did not exhibit antimicrobial activity.
Moujir
Laila
L
Department of Microbiology and Cellular Biology, and Instituto Canario de Investigación del Cáncer, University of La Laguna, 38206 La Laguna, Tenerife, Spain. lmoujir@ull.es
Seca
Ana M L
AM
Silva
Artur M S
AM
López
Manuel R
MR
Padilla
Nayely
N
Cavaleiro
José A S
JA
Neto
Carlos P
CP
D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D002455:Cell Division / Q000187:drug effects; D045744:Cell Line, Tumor / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D031584:Hibiscus; D006801:Humans; D017705:Lignans / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D008826:Microbial Sensitivity Tests; D008517:Phytotherapy; D024301:Plant Bark; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D000972:Antineoplastic Agents, Phytogenic; D017705:Lignans; D010936:Plant Extracts