Environmental Arsenic Exposure and Urinary 8-OHdG in Arizona and Sonora.
Although at high levels arsenic exposure is associated with increased cancer incidence, information on the health effects of lower exposure levels is limited. The objective of this study was to determine whether arsenic at concentrations below 40 microg/L in drinking water is associated with increased urinary 8-hydroxydeoxyguanosine (8-OHdG), a biomarker of DNA oxidative damage and repair. Urine samples were collected from 73 nonsmoking adults residing in two communities in Arizona (mean tap water arsenic (microg/L) 4.0 +/- 2.3 and 20.3 +/- 3.7), and 51 subjects in four communities in Sonora, Mexico (mean tap water arsenic (microg/L) ranging from 4.8 +/- 0.1 to 33.3 +/- 0.6). Although urinary arsenic concentration increased with higher exposure in tap water, urinary 8-OHdG concentration did not differ by community within Arizona or Sonora, and was not associated with urinary arsenic concentration. At the exposure levels evaluated in this study, drinking water arsenic was not associated with increased DNA oxidation as measured by urinary 8-OHdG.
Burgess
Jefferey L
JL
University of Arizona. Tucson, Arizona, USA. jburgess@u.arizona.edu
Meza
María M
MM
Josyula
Arun B
AB
Poplin
Gerald S
GS
Kopplin
Michael J
MJ
McClellen
Hannah E
HE
Stürup
Stefan
S
Lantz
R Clark
RC
D000080242:8-Hydroxy-2'-Deoxyguanosine; D000328:Adult; D000368:Aged; D001130:Arizona; D001151:Arsenic / Q000032:analysis / Q000652:urine*; D001152:Arsenicals / Q000652:urine; D015415:Biomarkers / Q000652:urine; D002101:Cacodylic Acid / Q000652:urine; D004247:DNA / Q000378:metabolism; D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000652:urine; D004784:Environmental Monitoring; D005260:Female; D006801:Humans; D008297:Male; D008800:Mexico; D008875:Middle Aged; D009262:Nails / Q000737:chemistry; D010084:Oxidation-Reduction; D014874:Water Pollutants, Chemical / Q000032:analysis / Q000652:urine*; D014881:Water Supply / Q000032:analysis
D001152:Arsenicals; D015415:Biomarkers; D014874:Water Pollutants, Chemical; D000080242:8-Hydroxy-2'-Deoxyguanosine; D004247:DNA; D002101:Cacodylic Acid; D003849:Deoxyguanosine; C020300:monomethylarsonic acid; D001151:Arsenic