title: Synthesis and antitumor evaluation of benzopsoralen analogues.
abstract: The synthesis of five new tetracyclic benzopsoralen analogues, compounds 2-6, with 9H-xanthen-9-one or 9H-carbazole frameworks, is described. Their inhibitory effects on the growth of three human tumor cell lines (MCF-7, SF-268, and NCI-460) were evaluated, and discussed in terms of structure-activity relationship, taking into account both geometric and electronic features. Generally, the angular compounds showed significant biological activities, but the arrangement of functional groups also contributed to the overall activity.
authors.affiliation: Centro de Química, Universidade do Minho, Campus de Gualtar, 4710-057 Braga, Portugal.
authors.forename: Ana M A G
authors.initials: AM
authors.lastname: Oliveira
authors.forename: Ana M F
authors.initials: AM
authors.lastname: Oliveira-Campos
authors.forename: Lígia M
authors.initials: LM
authors.lastname: Rodrigues
authors.forename: M Manuela M
authors.initials: MM
authors.lastname: Raposo
authors.forename: Antonio E H
authors.initials: AE
authors.lastname: Machado
authors.forename: M São José
authors.initials: MS
authors.lastname: Nascimento
authors.forename: N
authors.initials: N
authors.lastname: Nazareth
authors.forename: Madalena
authors.initials: M
authors.lastname: Pinto
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002227:Carbazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D011564:Furocoumarins / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D020128:Inhibitory Concentration 50; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D002227:Carbazoles; D011564:Furocoumarins