RTX toxin actin cross-linking activity in clinical and environmental isolates of Vibrio cholerae.
Vibrio cholerae strains from diverse O-antigen groups were evaluated for RTX toxin actin cross-linking activity. This study demonstrates that the actin cross-linking domain sequence is present within rtxA in the majority of clinical and environmental isolates tested, and the RTX toxin produced by these strains catalyzes the covalent cross-linking of cellular actin.
Cordero
Christina L
CL
Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, 303 E. Chicago Ave., Tarry 3-713, Chicago, IL 60611, USA.
Sozhamannan
Shanmuga
S
Satchell
Karla J Fullner
KJ
D000199:Actins / Q000378:metabolism*; D000942:Antigens, Bacterial / Q000235:genetics; D001427:Bacterial Toxins / Q000302:isolation & purification* / Q000494:pharmacology*; D002771:Cholera / Q000382:microbiology*; D004777:Environment; D006801:Humans; D014734:Vibrio cholerae / Q000235:genetics / Q000302:isolation & purification* / Q000378:metabolism*
D000199:Actins; D000942:Antigens, Bacterial; D001427:Bacterial Toxins