Globus pallidus internal segment.
The internal segment of the globus pallidus (GP(i)) gathers many bits of information including movement-related activity from the striatum, external segment of the globus pallidus (GP(e)), and subthalamic nucleus (STN), and integrates them. The GP(i) receives rich GABAergic inputs from the striatum and GP(e), and gamma-aminobutyric acid (GABA) receptors are distributed in the GP(i) in a specific manner. Thus, inputs from the striatum and GP(e) may control GP(i) activity in a different way. The GP(i) finally conveys processed information outside the basal ganglia. Changes in GABAergic neurotransmission have been reported in movement disorders and suggested to play an important role in the pathophysiology of the symptoms.
Nambu
Atsushi
A
Division of System Neurophysiology, National Institute for Physiological Sciences, 38 Nishigo-naka, Myodaiji, Okazaki 444-8585, Japan. nambu@nips.ac.jp
D000818:Animals; D050485:GABA Plasma Membrane Transport Proteins / Q000378:metabolism; D005917:Globus Pallidus / Q000033:anatomy & histology / Q000502:physiology*; D006801:Humans; D009068:Movement / Q000502:physiology; D009433:Neural Inhibition / Q000502:physiology; D009434:Neural Pathways / Q000033:anatomy & histology / Q000502:physiology*; D018079:Receptors, GABA / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
D050485:GABA Plasma Membrane Transport Proteins; D018079:Receptors, GABA; D005680:gamma-Aminobutyric Acid