Perinatal infections and cerebral palsy.
Cerebral palsy (CP) is a complex disease characterized by the aberrant control of movement or posture that appears in early life and affect about 2 per 1000 live-born children. CP represents the most common physical disability in childhood. An association between clinical chorioamnionitis and cerebral palsy has been recognised. Very low-birthweight infants constitute more than 1/4 of all new cases of cerebral palsy. The use of antimicrobial treatment of pregnant women with bacterial vaginosis, a complete course of antenatal steroids and magnesium sulphate are the most important strategies to prevent cerebral palsy.
Ribiani
E
E
Department of Obstetrics and Gynecology, Center for Perinatal Medicine and Human Reproduction, Policlinico Monteluce, University of Perugia, Padiglione 1, Via Brunamonte 51, 06122 Perugia, Italy.
Rosati
A
A
Romanelli
M
M
Cruciani
L
L
Incalza
F
F
Di Renzo
G C
GC
D002547:Cerebral Palsy / Q000209:etiology / Q000276:immunology / Q000382:microbiology* / Q000517:prevention & control; D016207:Cytokines / Q000276:immunology; D006801:Humans; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000382:microbiology*; D007239:Infections / Q000150:complications*; D007249:Inflammation / Q000150:complications
D016207:Cytokines