title: Mumps outbreak in a highly vaccinated school population: assessment of secondary vaccine failure using IgG avidity measurements.
abstract: From March to April 2006, an outbreak of mumps occurred in Gyeonggi, Korea. The aim of this study was to describe and discriminate between primary and secondary vaccine failure in a highly vaccinated population for mumps using IgG avidity testing. Fifteen clinical mumps cases occurred among 41 students. Among these 15 patients, 11 vaccinated patients were considered secondary vaccine failures with high IgG titers and a high avidity index (AI, > or =32%); an unvaccinated patient was considered to have primary infection with high IgG titers and low AI, and three vaccinated patients were considered as other infections with low IgG titers and low AI. Among 26 unaffected students, 5 vaccinated patients were retrospectively diagnosed as sub-clinical infection with high IgG titers and high AI; the remaining students had low IgG titers and low AI except for one previously infected student. The results of this study show that secondary vaccine failure played an important role in this mumps outbreak. Therefore, booster immunization for mumps should be considered in immunized adolescents to prevent further outbreaks.
authors.affiliation: Department of Internal Medicine, College of Medicine, Korea University, 126-1 Anam-dong 5th Str, Seongbuk-Gu, Seoul, Republic of Korea. pugae1@hanmail.net
authors.forename: Dae Won
authors.initials: DW
authors.lastname: Park
authors.forename: Myung-Hyun
authors.initials: MH
authors.lastname: Nam
authors.forename: Jung Yeon
authors.initials: JY
authors.lastname: Kim
authors.forename: Hee Jung
authors.initials: HJ
authors.lastname: Kim
authors.forename: Jang Wook
authors.initials: JW
authors.lastname: Sohn
authors.forename: Yunjung
authors.initials: Y
authors.lastname: Cho
authors.forename: Ki-Joon
authors.initials: KJ
authors.lastname: Song
authors.forename: Min Ja
authors.initials: MJ
authors.lastname: Kim
mesh_terms: D000293:Adolescent; D000914:Antibodies, Viral / Q000097:blood / Q000276:immunology; D000915:Antibody Affinity; D004196:Disease Outbreaks; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007723:Korea; D008297:Male; D009107:Mumps / Q000453:epidemiology* / Q000276:immunology*; D009108:Mumps Vaccine / Q000276:immunology*; D009109:Mumps virus / Q000276:immunology; D013334:Students
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G; D009108:Mumps Vaccine