title: CD3 and immunoglobulin G Fc receptor regulate cerebellar functions.
abstract: The immune and nervous systems display considerable overlap in their molecular repertoire. Molecules originally shown to be critical for immune responses also serve neuronal functions that include normal brain development, neuronal differentiation, synaptic plasticity, and behavior. We show here that FcgammaRIIB, a low-affinity immunoglobulin G Fc receptor, and CD3 are involved in cerebellar functions. Although membranous CD3 and FcgammaRIIB are crucial regulators on different cells in the immune system, both CD3epsilon and FcgammaRIIB are expressed on Purkinje cells in the cerebellum. Both CD3epsilon-deficient mice and FcgammaRIIB-deficient mice showed an impaired development of Purkinje neurons. In the adult, rotarod performance of these mutant mice was impaired at high speed. In the two knockout mice, enhanced paired-pulse facilitation of parallel fiber-Purkinje cell synapses was shared. These results indicate that diverse immune molecules play critical roles in the functional establishment in the cerebellum.
authors.affiliation: Department of Pathology, Juntendo University School of Medicine, Tokyo 113-8421, Japan. kaz@med.juntendo.ac.jp
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Nakamura
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Hirai
authors.forename: Takashi
authors.initials: T
authors.lastname: Torashima
authors.forename: Taisuke
authors.initials: T
authors.lastname: Miyazaki
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Tsurui
authors.forename: Yan
authors.initials: Y
authors.lastname: Xiu
authors.forename: Mareki
authors.initials: M
authors.lastname: Ohtsuji
authors.forename: Qing Shun
authors.initials: QS
authors.lastname: Lin
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Tsukamoto
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Nishimura
authors.forename: Masao
authors.initials: M
authors.lastname: Ono
authors.forename: Masahiko
authors.initials: M
authors.lastname: Watanabe
authors.forename: Sachiko
authors.initials: S
authors.lastname: Hirose
mesh_terms: D000818:Animals; D017252:CD3 Complex / Q000378:metabolism*; D002531:Cerebellum / Q000166:cytology / Q000254:growth & development / Q000378:metabolism*; D019706:Excitatory Postsynaptic Potentials; D051379:Mice; D008810:Mice, Inbred C57BL; D009412:Nerve Fibers / Q000378:metabolism; D011689:Purkinje Cells / Q000166:cytology / Q000378:metabolism; D017452:Receptors, IgG / Q000172:deficiency / Q000378:metabolism*; D045442:Rotarod Performance Test; D013569:Synapses / Q000378:metabolism
chemical_list: D017252:CD3 Complex; C485468:Cd3e protein, mouse; C499172:Fcgr2b protein, mouse; D017452:Receptors, IgG