title: Severe cognitive dysfunction in a patient with polyendocrinopathy.
abstract: BACKGROUND
  Polyglandular Autoimmune syndromes (PGAs) or polyendocrinopathies are immune mediated multiple endocrine gland failure sometimes accompanied by nonendocrine autoimmune disorders with varieties of presentations.
  
  
  METHODS
  We describe a case of a middle aged man with severe cognitive dysfunction, brain atrophy, adrenal insufficiency, hypothyroidism, renal failure, thrombocytopenia, and positive antiphospholipid antibodies, with significant renal and cognitive improvement after hormone replacement.
  
  
  CONCLUSIONS
  PGAs may present with a broad spectrum of manifestations related to different organs like nervous,renal,cardiac and hematopoietic systems, sometimes challenging both to physician and the patient.
authors.affiliation: Isfahan Endocrine & Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. siavash@med.mui.ac.ir
authors.forename: M Siavash
authors.initials: MS
authors.lastname: Dastjerdi
authors.forename: A
authors.initials: A
authors.lastname: Aminorroaya
authors.forename: M
authors.initials: M
authors.lastname: Amini
authors.forename: F
authors.initials: F
authors.lastname: Ashrafi
authors.forename: F
authors.initials: F
authors.lastname: Kazemi
authors.forename: M
authors.initials: M
authors.lastname: Saadatnia
authors.forename: P
authors.initials: P
authors.lastname: Mottaghi
authors.forename: A
authors.initials: A
authors.lastname: Emami
mesh_terms: D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016884:Polyendocrinopathies, Autoimmune / Q000150:complications* / Q000175:diagnosis