[Perioperative anti-inflammatory drug use: which evidences for their utility and safety?].
OBJECTIVE
To bring together the most recent evidences concerning the utility and safety of perioperative anti-inflammatory drug use.


METHODS
References were obtained from computerised bibliographic data banks (MeSH terms: NSAIDs, coxibs, steroids, surgery, anaesthesia), followed by manual search.


RESULTS
NSAIDs, coxibs and steroids used alone or in association have been demonstrated to be effective for relieving postoperative pain. However, the benefits of perioperative anti-inflammatory drug use may go beyond the postoperative analgesia. In some cases, anti-inflammatory drugs have been shown to decrease the incidence of morphine side-effects, postoperative nausea and vomiting or to improve postoperative recovery. Nevertheless, NSAIDs have been found to be a risk factor of severe postoperative bleeding requiring surgical haemostasis after some surgical procedures. In contrast, coxibs have been shown to promote arterial thrombosis after others surgical procedures.
Marret
E
E
Département d'anesthésie-réanimation, hôpital Tenon, Paris, France. emmanuel.marret@tnn.ap-hop-paris.fr <emmanuel.marret@tnn.ap-hop-paris.fr>
Bonnet
F
F
D000893:Anti-Inflammatory Agents / Q000009:adverse effects* / Q000627:therapeutic use*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000627:therapeutic use; D002319:Cardiovascular System / Q000187:drug effects; D004064:Digestive System / Q000187:drug effects; D006801:Humans; D007239:Infections / Q000139:chemically induced; D007668:Kidney / Q000187:drug effects; D019990:Perioperative Care; D012307:Risk Factors
D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal