title: Low plasma dehydroepiandrosterone sulfate level and its relationship to adiponectin in hemodialysis patients.
abstract: The aim of the present study was to assess the relationship between plasma DHEA-S and adiponectin concentrations in hemodialyses patients (HD). Plasma adiponectin, DHEA-S, cholesterol, and albumin levels were estimated in 94 HD and 46 healthy subjects (HS). In HD, a significantly lower plasma DHEA-S concentration (2.5+/-0.2 vs. 4.7+/-0.4 micromol/L respectively; p = 0.002) but significantly higher plasma adiponectin level (15.0+/-0.7 vs. 8.7+/-0.8 microg/mL respectively; p = 0.004) than in HS were found. Only in uremic patients was a significant negative correlation found between plasma adiponectin and DHEA-S concentrations (tau = -0.210; p = 0.001). Decreased plasma DHEA-S level is associated with increased adiponectinemia in uremic patients.
authors.affiliation: Department of Nephrology, Endocrinology and Metabolic Diseases, Medical University of Silesia in Katowice, Poland.
authors.forename: T
authors.initials: T
authors.lastname: Nieszporek
authors.forename: J
authors.initials: J
authors.lastname: Witkowicz
authors.forename: L
authors.initials: L
authors.lastname: Nowak
authors.forename: J
authors.initials: J
authors.lastname: Chudek
authors.forename: A
authors.initials: A
authors.lastname: Wiecek
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D000368:Aged; D019314:Dehydroepiandrosterone Sulfate / Q000097:blood*; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000401:mortality / Q000628:therapy; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis
chemical_list: D052242:Adiponectin; D019314:Dehydroepiandrosterone Sulfate