Pulp revascularization of immature dog teeth with apical periodontitis.
This study examined the ability of a collagen solution to aid revascularization of necrotic-infected root canals in immature dog teeth. Sixty immature teeth from 6 dogs were infected, disinfected, and randomized into experimental groups: 1: no further treatment; 2: blood in canal; 3: collagen solution in canal, 4: collagen solution + blood, and 5: negative controls (left for natural development). Uncorrected chi-square analysis of radiographic results showed no statistical differences (p >or= 0.05) between experimental groups regarding healing of radiolucencies but a borderline statistical difference (p = 0.058) for group 1 versus group 4 for radicular thickening. Group 2 showed significantly more apical closure than group 1 (p = 0.03) and a borderline statistical difference (p = 0.051) for group 3 versus group 1. Uncorrected chi-square analysis revealed that there were no statistical differences between experimental groups for histological results. However, some roots in each of groups 1 to 4 (previously infected) showed positive histologic outcomes (thickened walls in 43.9%, apical closure in 54.9%, and new luminal tissue in 29.3%). Revascularization of disinfected immature dog root canal systems is possible.
Thibodeau
Blayne
B
Department of Endodontics, University of North Carolina-Chapel Hill, School of Saskatoon, Canada. blaynethibodeau@gmail.com
Teixeira
Fabricio
F
Yamauchi
Mitsuo
M
Caplan
Daniel J
DJ
Trope
Martin
M
D000818:Animals; D016009:Chi-Square Distribution; D024042:Collagen Type I / Q000494:pharmacology*; D003782:Dental Pulp / Q000098:blood supply*; D003790:Dental Pulp Necrosis / Q000503:physiopathology; D004285:Dogs; D018919:Neovascularization, Physiologic / Q000187:drug effects*; D010485:Periapical Periodontitis / Q000000981:diagnostic imaging / Q000503:physiopathology*; D010486:Periapical Tissue / Q000098:blood supply; D011859:Radiography; D019227:Tooth Apex / Q000000981:diagnostic imaging / Q000254:growth & development*
D024042:Collagen Type I