title: Anxiety in mice: a principal component analysis study.
abstract: Two principal component analyses of anxiety were undertaken investigating two strains of mice (ABP/Le and C57BL/6ByJ) in two different experiments, both classical tests for assessing anxiety in rodents. The elevated plus-maze and staircase were used for the first experiment, and a free exploratory paradigm and light-dark discrimination were used for the second. The components in the analyses produced definitions of four fundamental behavior patterns: novelty-induced anxiety, general activity, exploratory behavior, and decision making. We also noted that the anxious phenotype was determined by both strain and experimental procedure. The relationship between behavior patterns and the use of specific tests plus links with the genetic background are discussed.
authors.affiliation: Groupe Hospitalier Pitié-Salpêtrière, CNRS UMR 7593, Université Paris 6, 91 Boulevard de l'Hôpital, 75634 Paris Cedex 13, France.
authors.forename: Yan
authors.initials: Y
authors.lastname: Clément
authors.forename: Chantal
authors.initials: C
authors.lastname: Joubert
authors.forename: Caroline
authors.initials: C
authors.lastname: Kopp
authors.forename: Eve M
authors.initials: EM
authors.lastname: Lepicard
authors.forename: Patrice
authors.initials: P
authors.lastname: Venault
authors.forename: René
authors.initials: R
authors.lastname: Misslin
authors.forename: Martine
authors.initials: M
authors.lastname: Cadot
authors.forename: Georges
authors.initials: G
authors.lastname: Chapouthier
mesh_terms: D000818:Animals; D001007:Anxiety / Q000235:genetics* / Q000503:physiopathology / Q000523:psychology*; D005106:Exploratory Behavior / Q000502:physiology; D005260:Female; D008297:Male; D051379:Mice / Q000235:genetics* / Q000523:psychology*; D008810:Mice, Inbred C57BL; D025341:Principal Component Analysis / Q000379:methods*; D013045:Species Specificity