title: The zebrafish model: use in studying cellular mechanisms for a spectrum of clinical disease entities.
abstract: Although the zebrafish model provides an important platform for the study of developmental biology, recent work with the zebrafish model has extended its application to a wide variety of experimental studies relevant to human disease. Currently, the zebrafish model is used for the study of human genetic disease, caveolin-associated muscle disease, homeostasis, kidney development and disease, cancer, cardiovascular disorders, oxidative stress, caloric restriction, insulin-like pathways, angiogenesis, neurological diseases, liver disease, hemophilia, bacterial pathogenesis, apoptosis, osteoporosis, immunological studies, germ cell study, Bardet-Biedl syndrome gene (BBS11), Alzheimer's disease, virology studies and vaccine development. Here we describe the essential use of the zebrafish model that applies to several clinical diseases. With increased understanding of the cellular mechanisms responsible for disease, we can use knowledge gained from the zebrafish model for the development of therapeutics.
authors.affiliation: Department of Marine Biotechnology and Resources, College of Marine Science, National Sun Yat-sen University, Kaohisung, Taiwan.
authors.forename: Chi-Hsin
authors.initials: CH
authors.lastname: Hsu
authors.forename: Zhi-Hong
authors.initials: ZH
authors.lastname: Wen
authors.forename: Chan-Shing
authors.initials: CS
authors.lastname: Lin
authors.forename: Chiranjib
authors.initials: C
authors.lastname: Chakraborty
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified; D035843:Biomedical Research; D004195:Disease Models, Animal; D006801:Humans; D015027:Zebrafish / Q000033:anatomy & histology / Q000235:genetics / Q000378:metabolism