title: Lung gas transfer in children with sickle cell anaemia.
abstract: The impact of sickle cell anaemia (SCA) on respiratory function of children must be determined if their management is to be optimised. Pulmonary diffusing capacity (DL(CO)), corrected for haemoglobin (DL(COc)), therefore was assessed in 24 children with SCA and 24 ethnic matched controls, mean age 11 (range 7-16) years. To determine if any differences found correlated with other measures of lung function, spirometry was undertaken and lung volumes assessed. The SCA children compared to the controls had lower weight (p=0.01), body mass index (p=0.002), DL(CO) (p<0.0001), K(CO) (p=0.003), V(CSB) (p=0.01), FEV(1) (p<0.0001) and FVC (p<0.0001), but greater K(COc) (p=0.001). K(COc) results correlated significantly with PEF (r=-0.58, p=0.02), but not TLC(pleth) (p=0.36), FEV(1) (0.39) or FVC (p=0.36). In conclusion, when corrected for haemoglobin levels, the SCA children compared to controls of similar age had elevated gas transfer per unit lung volume results. Our results suggest this abnormality is independent of other lung function abnormalities.
authors.affiliation: King's College London, MRC-Asthma Centre, Division of Asthma, Allergy and Lung Biology, King's College Hospital, Denmark Hill, London SE5 9RS, UK.
authors.forename: Karl P
authors.initials: KP
authors.lastname: Sylvester
authors.forename: Richard A
authors.initials: RA
authors.lastname: Patey
authors.forename: Zainab
authors.initials: Z
authors.lastname: Kassim
authors.forename: Gerrard F
authors.initials: GF
authors.lastname: Rafferty
authors.forename: David
authors.initials: D
authors.lastname: Rees
authors.forename: Swee Lay
authors.initials: SL
authors.lastname: Thein
authors.forename: Anne
authors.initials: A
authors.lastname: Greenough
mesh_terms: D000293:Adolescent; D000755:Anemia, Sickle Cell / Q000097:blood / Q000503:physiopathology*; D001784:Blood Gas Analysis; D015992:Body Mass Index; D002648:Child; D005541:Forced Expiratory Volume; D006801:Humans; D008168:Lung / Q000503:physiopathology*; D012016:Reference Values; D012129:Respiratory Function Tests