title: Achievement of immune tolerance in a patient with haemophilia B and inhibitory antibodies, complicated by an anaphylactoid reaction.
abstract: We describe a young boy with severe haemophilia B who developed inhibitory antibodies and an anaphylactoid reaction to factor IX. Immune tolerance was achieved by desensitisation with escalating doses of factor IX followed by the Malmö regimen.
authors.affiliation: Oxford Haemophilia Centre and Thrombosis Unit, Oxford Radcliffe Hospitals, Oxford, UK.
authors.forename: N S
authors.initials: NS
authors.lastname: Curry
authors.forename: S A
authors.initials: SA
authors.lastname: Misbah
authors.forename: P L F
authors.initials: PL
authors.lastname: Giangrande
authors.forename: D M
authors.initials: DM
authors.lastname: Keeling
mesh_terms: D000707:Anaphylaxis / Q000276:immunology*; D000906:Antibodies / Q000276:immunology; D002675:Child, Preschool; D004334:Drug Administration Schedule; D005164:Factor IX / Q000009:adverse effects*; D002836:Hemophilia B / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance; D008297:Male; D016896:Treatment Outcome
chemical_list: D000906:Antibodies; D005164:Factor IX