title: MRI/TRUS data fusion for brachytherapy.
abstract: BACKGROUND
  Prostate brachytherapy consists in placing radioactive seeds for tumour destruction under transrectal ultrasound imaging (TRUS) control. It requires prostate delineation from the images for dose planning. Because ultrasound imaging is patient- and operator-dependent, we have proposed to fuse MRI data to TRUS data to make image processing more reliable. The technical accuracy of this approach has already been evaluated.
  
  
  METHODS
  We present work in progress concerning the evaluation of the approach from the dosimetry viewpoint. The objective is to determine what impact this system may have on the treatment of the patient. Dose planning is performed from initial TRUS prostate contours and evaluated on contours modified by data fusion.
  
  
  RESULTS
  For the eight patients included, we demonstrate that TRUS prostate volume is most often underestimated and that dose is overestimated in a correlated way. However, dose constraints are still verified for those eight patients.
  
  
  CONCLUSIONS
  This confirms our initial hypothesis.
authors.affiliation: TIMC Laboratory, Grenoble, France.
authors.forename: V
authors.initials: V
authors.lastname: Daanen
authors.forename: J
authors.initials: J
authors.lastname: Gastaldo
authors.forename: J Y
authors.initials: JY
authors.lastname: Giraud
authors.forename: P
authors.initials: P
authors.lastname: Fourneret
authors.forename: J L
authors.initials: JL
authors.lastname: Descotes
authors.forename: M
authors.initials: M
authors.lastname: Bolla
authors.forename: D
authors.initials: D
authors.lastname: Collomb
authors.forename: J
authors.initials: J
authors.lastname: Troccaz
mesh_terms: D001918:Brachytherapy / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods*; D008297:Male; D019047:Phantoms, Imaging; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000532:radiotherapy*; D019919:Prosthesis Implantation / Q000379:methods; D011881:Radiotherapy, Computer-Assisted / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013382:Subtraction Technique; D014463:Ultrasonography / Q000295:instrumentation / Q000379:methods*