[Optimization of formulation matrix proportion and preparation technology of realgar floating tablets for gastric retention by uniform design and correlation analysis].
OBJECTIVE
To optimize the different components proportions of the Realgar floating tablets for gastric retention by uniform design and correlation analysis.


METHODS
With the different dosage of hydroxypropyl methyl cellulose (HPMC) as the tablets frame matrix, uniform design and correlation analysis were used to optimize the best component proportions of formula, and to measure the dissolution of the tablets in vitro.


RESULTS
Dissolution of the tablets in vitro was conformed to the expectation of experiment. The drug-release mechanism was by diffusion and corrosion at the same time.


CONCLUSIONS
The Realgar floating tablets for gastric retention achieved the goal of design, which demand sustained release and safety.
Yang
Chang-Fu
CF
Guiyang College of Traditional Chinese Medicine, Guiyang 550002 China.
Lin
Ya-Ping
YP
Zhong
Yong-Ping
YP
Qi
Feng-Yun
FY
Chen
Xiao-Lan
XL
D000284:Administration, Oral; D001152:Arsenicals / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics; D003692:Delayed-Action Preparations; D005753:Gastric Mucosa / Q000378:metabolism*; D065347:Hypromellose Derivatives; D008419:Materia Medica / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics; D008747:Methylcellulose / Q000031:analogs & derivatives / Q000737:chemistry; D011205:Povidone / Q000737:chemistry; D012995:Solubility; D013440:Sulfides / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics; D013607:Tablets; D013678:Technology, Pharmaceutical / Q000379:methods*
D001152:Arsenicals; D003692:Delayed-Action Preparations; D008419:Materia Medica; D013440:Sulfides; D013607:Tablets; D065347:Hypromellose Derivatives; C058317:arsenic disulfide; D008747:Methylcellulose; D011205:Povidone