title: Prevention measures for ventilator-associated pneumonia: a new focus on the endotracheal tube.
abstract: OBJECTIVE
  The aim of this article is to analyze the aspects related to the endotracheal tube which may influence the development of ventilator-associated pneumonia and to review the possible measures of prevention.
  
  
  RESULTS
  The endotracheal tube participates in the pathogenesis of ventilator-associated pneumonia by the elimination of natural defense mechanisms, thereby allowing the entry of bacteria by the aspiration of subglottic secretions or the formation of biofilm on the endotracheal tube. The preventive measures of ventilator-associated pneumonia related to the endotracheal tube include these two mechanisms. It has been suggested that substitution of the endotracheal tube by early tracheostomy may reduce the risk of ventilator-associated pneumonia.
  
  
  CONCLUSIONS
  Aspiration of the subglottic secretions seems to be an effective measure with little risk; decontamination or exhaustive control of the sealing of the cuff has not demonstrated a positive risk/benefit balance. The causal relationship between biofilm and ventilator-associated pneumonia has not been clearly established. Treatment of the biofilm with antibiotics, changes in the composition of the endotracheal tube or mechanical cleansing have achieved a reduction or elimination of the biofilm but their effect on the incidence of ventilator-associated pneumonia has not been studied. The benefit of early tracheostomy in reducing ventilator-associated pneumonia is still controversial.
authors.affiliation: Intensive Care Unit, Hospital Universitario La Fe, Valencia, Spain.
authors.forename: Paula
authors.initials: P
authors.lastname: Ramirez
authors.forename: Miquel
authors.initials: M
authors.lastname: Ferrer
authors.forename: Antoni
authors.initials: A
authors.lastname: Torres
mesh_terms: D018441:Biofilms / Q000254:growth & development; D003666:Decontamination / Q000379:methods; D004209:Disposable Equipment / Q000382:microbiology; D005931:Glottis / Q000378:metabolism* / Q000382:microbiology; D006801:Humans; D007442:Intubation, Intratracheal / Q000295:instrumentation*; D053717:Pneumonia, Ventilator-Associated / Q000517:prevention & control*; D016032:Randomized Controlled Trials as Topic; D014139:Tracheostomy