Growth hormone treatment and left ventricular dimensions in Turner syndrome.
OBJECTIVE
To determine whether cardiac dimensions were different in girls with Turner syndrome (TS) who received growth hormone (GH) compared with those who did not receive GH.


METHODS
This retrospective, cross-sectional study analyzed echocardiograms in 86 females with TS divided into GH-treated (n = 67) and untreated (n = 19) groups. The subjects all participated in the National Institutes of Health protocol between 2001 and 2006.


RESULTS
The average age was 16.2 years (range, 10 to 25 years), and average duration of GH treatment was 4.4 years (range, 1 to 14 years). The GH-treated group was taller by approximately 7 cm (P = .004), but cardiac dimensions normalized to body surface area (BSA), including septal and posterior wall thickness and left ventricular (LV) mass and internal diameters, did not differ significantly between the 2 groups. The fractional shortening index was similar in the 2 groups. Multiple regression analyses indicated that BSA, but not duration of GH treatment, predicted LV dimensions in girls with TS.


CONCLUSIONS
GH treatment of girls with TS increases stature but does not disproportionately affect cardiac dimensions.
Matura
Lea Ann
LA
Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA. maturale@mail.nih.gov
Sachdev
Vandana
V
Bakalov
Vladimir K
VK
Rosing
Douglas R
DR
Bondy
Carolyn A
CA
D000293:Adolescent; D000328:Adult; D001830:Body Surface Area; D002648:Child; D003430:Cross-Sectional Studies; D015150:Echocardiography, Doppler; D005260:Female; D013006:Growth Hormone / Q000627:therapeutic use*; D006321:Heart / Q000187:drug effects*; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000187:drug effects*; D019382:Human Growth Hormone / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D012044:Regression Analysis; D014424:Turner Syndrome / Q000000981:diagnostic imaging* / Q000188:drug therapy* / Q000503:physiopathology
D019382:Human Growth Hormone; D013006:Growth Hormone