title: Effect of neutralization of poly(methacrylic acid-co-ethyl acrylate) on drug release from enteric-coated pellets upon accelerated storage.
abstract: The effect of neutralization of poly(methacrylic acid-co-ethyl acrylate) or poly(MA-EA) 1:1 (Eudragit L 30 D-55) on drug release from enteric-coated pellets was studied upon accelerated storage. The dissolution rate of un-neutralized poly(MA-EA)-coated pellets decreased while the neutralized polymer-coated pellets maintained a constant drug release rate. Dynamic mechanical analysis showed that both un-neutralized and neutralized poly(MA-EA) films became rigid on aging. However, the un-neutralized films were affected more than those neutralized. Neutralization of poly(MA-EA) significantly changed the mechanical properties of coating films and improved the stability of poly(MA-EA) enteric-coated pellets upon accelerated storage at the studied conditions.
authors.affiliation: Research and Development, Barr Laboratories, Inc., Pomona, NY 10970-0519, USA.
authors.forename: Yanming
authors.initials: Y
authors.lastname: Zu
authors.forename: Yi
authors.initials: Y
authors.lastname: Luo
authors.forename: Salah Uddin
authors.initials: SU
authors.lastname: Ahmed
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry*; D002214:Capsules; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000737:chemistry*; D004349:Drug Packaging; D004355:Drug Stability; D004356:Drug Storage; D006863:Hydrogen-Ion Concentration; D007840:Latex; D008689:Methacrylates / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D010316:Particle Size; D018583:Pliability; D011108:Polymers; D012212:Rheology; D012995:Solubility; D013696:Temperature; D014783:Viscosity
chemical_list: D000180:Acrylic Resins; D002214:Capsules; D003692:Delayed-Action Preparations; D004337:Drug Carriers; C477852:Eudragit L 30 D-55; C446821:Eudragit L100-55; D007840:Latex; D008689:Methacrylates; D011108:Polymers