Delivery of prazosin hydrochloride from osmotic pump system prepared by coating the core tablet with an indentation.
The preparation of an osmotic pump tablet was simplified by elimination of laser drilling using prazosin hydrochloride as the model drug. The osmotic pump system was obtained by coating the indented core tablet compressed by the punch with a needle. A multiple regression equation was achieved with the experimental data of core tablet formulations, and then the formulation was optimized. The influences of the indentation size of the core tablet, environmental media, and agitation rate on drug release profile were investigated. The optimal osmotic pump tablet was found to deliver prazosin hydrochloride at an approximately constant rate up to 24 hr, and independent on both release media and agitation rate. Indentation size of core tablet hardly affected drug release in the range of 0.80-1.15 mm. The method that is simplified by elimination of laser drilling may be promising for preparation of an osmotic pump tablet.
Liu
Longxiao
L
College of Pharmaceutical Sciences, Zhejiang University, People's Republic of China. liulx@zju.edu.cn
Wang
Jinchao
J
Zhu
Suyan
S
D000317:Adrenergic alpha-Antagonists / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D005079:Excipients / Q000737:chemistry; D005240:Feasibility Studies; D007700:Kinetics; D008956:Models, Chemical; D009997:Osmotic Pressure; D010539:Permeability; D011092:Polyethylene Glycols / Q000737:chemistry; D011224:Prazosin / Q000737:chemistry*; D012965:Sodium Chloride / Q000737:chemistry*; D012995:Solubility; D013607:Tablets; D013678:Technology, Pharmaceutical / Q000379:methods*
D000317:Adrenergic alpha-Antagonists; D003692:Delayed-Action Preparations; D005079:Excipients; D013607:Tablets; D011092:Polyethylene Glycols; D012965:Sodium Chloride; D011224:Prazosin