Comment on "A centrosome-independent role for gamma-TuRC proteins in the spindle assembly checkpoint".
Müller et al. (Reports, 27 October 2006, p. 654) showed that inhibition of the gamma-tubulin ring complex (gamma-TuRC) activates the spindle assembly checkpoint (SAC), which led them to suggest that gamma-TuRC proteins play molecular roles in SAC activation. Because gamma-TuRC inhibition leads to pleiotropic spindle defects, which are well known to activate kinetochore-derived checkpoint signaling, we believe that this conclusion is premature.
Taylor
Stephen S
SS
Faculty of Life Sciences, University of Manchester, Manchester, UK. stephen.taylor@manchester.ac.uk
Hardwick
Kevin G
KG
Sawin
Kenneth E
KE
Biggins
Sue
S
Piatti
Simonetta
S
Khodjakov
Alexey
A
Rieder
Conly L
CL
Salmon
Edward D
ED
Musacchio
Andrea
A
D000818:Animals; D018385:Centrosome / Q000502:physiology; D018386:Kinetochores / Q000502:physiology*; D008869:Microtubule-Associated Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism*; D008870:Microtubules / Q000378:metabolism* / Q000648:ultrastructure; D008938:Mitosis; D015398:Signal Transduction; D008941:Spindle Apparatus / Q000378:metabolism*; D014404:Tubulin / Q000378:metabolism*
D008869:Microtubule-Associated Proteins; D014404:Tubulin