Oscillatory potentials of the slow-sequence multifocal ERG in primates extracted using the Matching Pursuit method.
This study used the Matching Pursuit (MP) method, a time-frequency analysis, to identify and characterize oscillatory potentials (OPs) in the primate electroretinogram (ERG). When the slow-sequence mfERG from the macular region of the retina was matched with Gabor functions, OPs were identified in two distinct bands: a high-frequency band peaking around 150 Hz that contributes to early OPs, and a low-frequency band peaking around 80 Hz that contributes to both early and late OPs. Pharmacological blockade and experimental glaucoma studies showed that the high-frequency OPs depend upon sodium-dependent spiking activity of retinal ganglion cells, whereas the low-frequency OPs depend primarily upon non-spiking activity of amacrine cells, and more distal retinal activity.
Zhou
Wei
W
College of Optometry, University of Houston, Houston, TX, USA. franch9@hotmail.com
Rangaswamy
Nalini
N
Ktonas
Periklis
P
Frishman
Laura J
LJ
D000818:Animals; D004195:Disease Models, Animal; D004596:Electroretinography; D005901:Glaucoma / Q000503:physiopathology; D008251:Macaca; D016202:N-Methylaspartate; D010775:Photic Stimulation / Q000379:methods; D010875:Pipecolic Acids; D012160:Retina / Q000502:physiology* / Q000503:physiopathology; D012165:Retinal Ganglion Cells / Q000502:physiology; D012815:Signal Processing, Computer-Assisted; D013779:Tetrodotoxin; D005680:gamma-Aminobutyric Acid
D010875:Pipecolic Acids; D013779:Tetrodotoxin; C029262:2,3-piperidinedicarboxylic acid; D005680:gamma-Aminobutyric Acid; D016202:N-Methylaspartate