title: Nuclear microenvironments in biological control and cancer.
abstract: Nucleic acids and regulatory proteins are compartmentalized in microenvironments within the nucleus. This subnuclear organization may support convergence and the integration of physiological signals for the combinatorial control of gene expression, DNA replication and repair. Nuclear organization is modified in many cancers. There are cancer-related changes in the composition, organization and assembly of regulatory complexes at intranuclear sites. Mechanistic insights into the temporal and spatial organization of machinery for gene expression within the nucleus, which is compromised in tumours, provide a novel platform for diagnosis and therapy.
authors.affiliation: University of Massachusetts Medical School and UMASS Memorial Cancer Center, Worcester, Massachusetts, USA.
authors.forename: Sayyed K
authors.initials: SK
authors.lastname: Zaidi
authors.forename: Daniel W
authors.initials: DW
authors.lastname: Young
authors.forename: Amjad
authors.initials: A
authors.lastname: Javed
authors.forename: Jitesh
authors.initials: J
authors.lastname: Pratap
authors.forename: Martin
authors.initials: M
authors.lastname: Montecino
authors.forename: Andre
authors.initials: A
authors.lastname: van Wijnen
authors.forename: Jane B
authors.initials: JB
authors.lastname: Lian
authors.forename: Janet L
authors.initials: JL
authors.lastname: Stein
authors.forename: Gary S
authors.initials: GS
authors.lastname: Stein
mesh_terms: D021581:Active Transport, Cell Nucleus; D002451:Cell Compartmentation; D002467:Cell Nucleus / Q000502:physiology* / Q000648:ultrastructure; D050657:Core Binding Factor alpha Subunits / Q000502:physiology; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000235:genetics* / Q000648:ultrastructure*; D015530:Nuclear Matrix; D012045:Regulatory Sequences, Nucleic Acid
chemical_list: D050657:Core Binding Factor alpha Subunits