Neurophysiology of synesthesia.
Synesthesia is an experience in which stimulation in one sensory or cognitive stream leads to associated experiences in a second, unstimulated stream. Although synesthesia is often referred to as a "neurological condition," it is not listed in the DSM IV or the ICD classifications, as it generally does not interfere with normal daily functioning. However, its high prevalence rate (one in 23) means that synesthesia may be reported by patients who present with other psychiatric symptoms. In this review, I focus on recent research examining the neural basis of the two most intensively studied forms of synesthesia, grapheme --> color synesthesia and tone --> color synesthesia. These data suggest that these forms of synesthesia are elicited through anomalous activation of color-selective areas, perhaps in concert with hyperbinding mediated by the parietal cortex. I then turn to questions for future research and the implications of these models for other forms of synesthesia.
Hubbard
Edward M
EM
INSERM Unité 562-Neuroimagerie Cognitive, CEA/SAC/DSV/DRM/NEUROSPIN, Bât 145, Point courrier 156, 91191 Gif-Sur-Yvette, France. edhubbard@gmail.com
D001244:Association; D002540:Cerebral Cortex / Q000503:physiopathology*; D003118:Color Perception / Q000502:physiology*; D004569:Electroencephalography; D006801:Humans; D008279:Magnetic Resonance Imaging; D015225:Magnetoencephalography; D008959:Models, Neurological; D010296:Parietal Lobe / Q000503:physiopathology; D010364:Pattern Recognition, Visual / Q000502:physiology*; D010468:Perceptual Disorders / Q000503:physiopathology*; D010898:Pitch Perception / Q000502:physiology*; D049268:Positron-Emission Tomography; D011932:Reading; D012660:Semantics; D014793:Visual Cortex / Q000503:physiopathology; D014796:Visual Perception / Q000502:physiology