title: Occupational allergy to latex among loom tuners in a textile factory.
abstract: BACKGROUND
  Occupational allergy to latex is generally reported from occupational groups such as health care workers; however, few reports derive from other occupational settings.
  
  
  METHODS
  Two male subjects working as loom tuners in a textile manufacturing plant developed severe allergic reactions during the cutting and weaving of elastic bands, initially not suspected to contain latex constituents. Clinical evaluation and lung function tests were supplemented by skin prick testing, specific IgE evaluation and basophil activation assays with extracted elastic bands.
  
  
  RESULTS
  Both workers presented with rhinitis, episodes of tight chest and itchy eyes. Initial spirometry was normal with no significant reversibility; however, a histamine challenge test was positive in one worker. Skin prick testing to a battery of common inhalant allergens was negative; however, raised IgE levels were detected to latex using ImmunoCAP. On further testing, the specific IgE response was directed mainly to the major latex allergens rHev b 5, rHev b 6.01, rHev b 6.02 and nHev b 13. Basophils of the two workers, but not the unaffected control subjects, were strongly activated by extracts of the elastic and the cutting dust material.
  
  
  CONCLUSIONS
  Workers are at high risk of becoming sensitised to latex allergens when exposed to excessive dust produced by loom tuning machines. Latex sensitisation should therefore be considered in workers developing unexplained work-related allergic reactions (including asthma) associated with unlabelled materials in the textile industry.
authors.affiliation: Allergy and Asthma Research Group, Division of Immunology, Institute of Infectious Diseases and Molecular Medicine, Faculty of Health Sciences, National Health Laboratory Service, University of Cape Town, Cape Town, South Africa. alopata@uctgsh1.uct.ac.za
authors.forename: Andreas L
authors.initials: AL
authors.lastname: Lopata
authors.forename: Shahieda
authors.initials: S
authors.lastname: Adams
authors.forename: Frank
authors.initials: F
authors.lastname: Kirstein
authors.forename: Nick
authors.initials: N
authors.lastname: Henwood
authors.forename: Monika
authors.initials: M
authors.lastname: Raulf-Heimsoth
authors.forename: Mohamed F
authors.initials: MF
authors.lastname: Jeebhay
mesh_terms: D000328:Adult; D000485:Allergens / Q000009:adverse effects* / Q000276:immunology; D028482:Hevea / Q000009:adverse effects / Q000276:immunology; D006801:Humans; D007221:Industry; D007840:Latex / Q000009:adverse effects / Q000276:immunology; D020315:Latex Hypersensitivity / Q000276:immunology*; D008297:Male; D009784:Occupational Diseases / Q000276:immunology*; D013784:Textiles
chemical_list: D000485:Allergens; D007840:Latex