Role of aralar, the mitochondrial transporter of aspartate-glutamate, in brain N-acetylaspartate formation and Ca(2+) signaling in neuronal mitochondria.
Aralar, the Ca(2+)-dependent mitochondrial aspartate-glutamate carrier expressed in brain and skeletal muscle, is a member of the malate-aspartate NADH shuttle. Disrupting the gene for aralar, SLC25a12, in mice has enabled the discovery of two new roles of this carrier. On the one hand, it is required for synthesis of brain aspartate and N-acetylaspartate, a neuron-born metabolite that supplies acetate for myelin lipid synthesis; and on the other, it is essential for the transmission of small Ca(2+) signals to mitochondria via an increase in mitochondrial NADH.
Satrústegui
Jorgina
J
Departamento de Biología Molecular, Centro de Biología Molecular Severo Ochoa, Facultad de Ciencias, Universidad Autónoma, 28049, Cantoblanco, Madrid, Spain jsatrustegui@cbm.uam.es
Contreras
Laura
L
Ramos
Milagros
M
Marmol
Patricia
P
del Arco
Araceli
A
Saheki
Takeyori
T
Pardo
Beatriz
B
D000818:Animals; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000096:biosynthesis; D001921:Brain / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism*; D006801:Humans; D026901:Membrane Transport Proteins / Q000378:metabolism*; D051379:Mice; D008928:Mitochondria / Q000378:metabolism*; D033681:Mitochondrial Membrane Transport Proteins; D024101:Mitochondrial Proteins / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism*
D026901:Membrane Transport Proteins; D033681:Mitochondrial Membrane Transport Proteins; D024101:Mitochondrial Proteins; C491956:Slc25a12 protein, mouse; D001224:Aspartic Acid; C000179:N-acetylaspartate; D002118:Calcium