title: Stable isotope pilot study of exchangeable copper kinetics in human blood plasma.
abstract: To develop further our understanding of initial dietary copper metabolism, a method has been developed to separate plasma copper that is bound to albumin, from that bound to ceruloplasmin. This method has been tested using plasma samples from a pilot study involving six human volunteers who consumed 3mg oral doses of the stable isotope (65)Cu and gave blood samples at timed intervals up to 7 days. The results suggest that this method can be used to monitor dynamic fluctuations in newly absorbed copper over a short time frame.
authors.affiliation: Sofia University, Faculty of Chemistry, 1 J. Bourchier Blvd., 1164 Sofia, Bulgaria.
authors.forename: Tony I
authors.initials: TI
authors.lastname: Venelinov
authors.forename: John H
authors.initials: JH
authors.lastname: Beattie
authors.forename: Jack R
authors.initials: JR
authors.lastname: Dainty
authors.forename: Wendy J
authors.initials: WJ
authors.lastname: Hollands
authors.forename: Susan J
authors.initials: SJ
authors.lastname: Fairweather-Tait
authors.forename: Linda J
authors.initials: LJ
authors.lastname: Harvey
mesh_terms: D000418:Albumins / Q000378:metabolism; D002570:Ceruloplasmin / Q000378:metabolism; D003301:Copper Radioisotopes / Q000097:blood* / Q000493:pharmacokinetics; D006801:Humans; D010865:Pilot Projects; D010949:Plasma / Q000737:chemistry*
chemical_list: D000418:Albumins; D003301:Copper Radioisotopes; D002570:Ceruloplasmin