Expression of CD80 and CD86 costimulatory molecules are potential markers for better survival in nasopharyngeal carcinoma.
BACKGROUND
B7 Costimulatory signal is essential to trigger T-cell activation upon the recognition of tumor antigens. This study examined the expression of B7-1 (CD80) and B7-2 (CD86) costimulatory molecules along with HLA-DR and the presence of infiltrating lymphocytes and dendritic cells to assess their significance in patients with nasopharyngeal carcinoma (NPC).


METHODS
Expression of CD80, CD86, HLA-DR, S-100 protein and the presence of infiltrating lymphocytes and follicular dendritic reticulum cells were immunohistochemically examined on the paraffin-embedded tissue blocks from newly diagnosed NPC patients (n = 50). The results were correlated with clinical outcome of patients.


RESULTS
CD80 and CD86 were each expressed in 10 of 50 cases in which they co-expressed in 9 cases. Univariate analysis revealed that patients with CD80/CD86 expression had significantly better overall survival than those without it (P = 0.017), but after adjustment for stage, nodal status, and treatment, the expression of CD80/CD86 did not significantly correlate with overall survival. Expression of HLA-DR and the presence of infiltrating lymphocytes and dendritic cells did not appear to have impact on the survival of patients.


CONCLUSIONS
Expression of CD80 and CD86 costimulatory molecules appears to be a marker of better survival in patient with NPC.
Chang
Cheng-Shyong
CS
Division of Hematology-Oncology, Department of Internal Medicine, Changhua Christian Hospital, Changhua, Taiwan. 15120@cch.org.tw
Chang
Julia H
JH
Hsu
Nicholas C
NC
Lin
Hsuan-Yu
HY
Chung
Chih-Yuan
CY
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018122:B7-1 Antigen / Q000096:biosynthesis / Q000235:genetics*; D051940:B7-2 Antigen / Q000096:biosynthesis / Q000235:genetics*; D014408:Biomarkers, Tumor / Q000096:biosynthesis / Q000235:genetics*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000401:mortality*; D015996:Survival Rate / Q000639:trends
D018122:B7-1 Antigen; D051940:B7-2 Antigen; D014408:Biomarkers, Tumor