Two new non-competitive mGlu1 receptor antagonists are potent tools to unravel functions of this mGlu receptor subtype.
The validation of the selective, potent and systemically active non-competitive mGlu1 antagonists YM-298198 and JNJ16259685 in a physiological functional assay will facilitate elucidation of this receptor's role in brain function and as a potential drug target.
Knöpfel
T
T
Laboratory for Neuronal Circuit Dynamics, RIKEN BSI, Wako-shi, Saitama, Japan. tknopfel@brain.riken.jp
D001562:Benzimidazoles / Q000494:pharmacology*; D001921:Brain / Q000502:physiology; D016503:Drug Delivery Systems; D004594:Electrophysiology; D006801:Humans; D011804:Quinolines / Q000494:pharmacology*; D018094:Receptors, Metabotropic Glutamate / Q000037:antagonists & inhibitors* / Q000502:physiology; D009435:Synaptic Transmission; D013844:Thiazoles / Q000494:pharmacology*
C495417:(3,4-dihydro-2H-pyrano(2,3)b-quinolin-7-yl)-(cis-4-methoxycyclohexyl) methanone; C505455:6-amino-N-cyclohexyl-N,3-dimethylthiazolo(3,2-a)benzimidazole-2-carboxamide; D001562:Benzimidazoles; D011804:Quinolines; D018094:Receptors, Metabotropic Glutamate; D013844:Thiazoles; C104077:metabotropic glutamate receptor type 1