T cells doing it for themselves: TGF-beta regulation of Th1 and Th17 cells.
The source of TGF-beta, which regulates inflammation in various disease settings, is unclear. In this issue of Immunity, Li et al. (2007) find that not only does T cell-produced TGF-beta regulate Th1-cell-mediated inflammation, but it is also required for the generation of Th17 cells in vivo.
McGeachy
Mandy J
MJ
Schering-Plough Biopharma, 901 California Avenue, Palo Alto, California 94304, USA.
Cua
Daniel J
DJ
D000818:Animals; D002454:Cell Differentiation / Q000276:immunology*; D019070:Cell Lineage; D005786:Gene Expression Regulation / Q000276:immunology*; D013601:T-Lymphocytes / Q000166:cytology* / Q000276:immunology / Q000378:metabolism*; D053773:Transforming Growth Factor beta1 / Q000096:biosynthesis* / Q000235:genetics
D053773:Transforming Growth Factor beta1