title: ApoER2/VLDL receptor and Dab1 in the rostral migratory stream function in postnatal neuronal migration independently of Reelin.
abstract: Postnatal migration of interneuron precursors from the subventricular zone to the olfactory bulb occurs in chains that form the substrate for the rostral migratory stream. Reelin is suggested to induce detachment of neuroblasts from the chains when they arrive at the olfactory bulb. Here we show that ApoER2 and possibly very-low-density lipoprotein receptor (VLDLR) and their intracellular adapter protein Dab1 are involved in chain formation most likely independent of Reelin. F-spondin, which is present in the stream, may act as ligand for ApoER2 and VLDLR. In mice lacking either both receptors or Dab1 chain formation is severely compromised, and as a consequence the rostral migratory stream is virtually absent and neuroblasts accumulate in the subventricular zone. The mutant animals exhibit severe neuroanatomical defects in the subventricular zone and in the olfactory bulb. These data demonstrate a cell-autonomous function of ApoER2, and most likely VLDLR and Dab1, in postnatal migration of neuroblasts in the forebrain, which is suggested to depend on ligands other than Reelin.
authors.affiliation: Max F. Perutz Laboratories, University Departments at the Vienna Biocenter, Department of Medical Biochemistry, Medical University of Vienna, A-1030 Vienna, Austria.
authors.forename: Nuno
authors.initials: N
authors.lastname: Andrade
authors.forename: Vukoslav
authors.initials: V
authors.lastname: Komnenovic
authors.forename: Sophia M
authors.initials: SM
authors.lastname: Blake
authors.forename: Yves
authors.initials: Y
authors.lastname: Jossin
authors.forename: Brian
authors.initials: B
authors.lastname: Howell
authors.forename: Andre
authors.initials: A
authors.lastname: Goffinet
authors.forename: Wolfgang J
authors.initials: WJ
authors.lastname: Schneider
authors.forename: Johannes
authors.initials: J
authors.lastname: Nimpf
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000166:cytology*; D015816:Cell Adhesion Molecules, Neuronal / Q000172:deficiency / Q000378:metabolism; D002465:Cell Movement; D016326:Extracellular Matrix Proteins / Q000172:deficiency / Q000378:metabolism; D026502:LDL-Receptor Related Proteins; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009419:Nerve Tissue Proteins / Q000172:deficiency / Q000378:metabolism*; D009474:Neurons / Q000166:cytology*; D009830:Olfactory Bulb / Q000166:cytology; D011973:Receptors, LDL / Q000378:metabolism*; D018110:Receptors, Lipoprotein / Q000172:deficiency / Q000378:metabolism*; D000091042:Reelin Protein; D012697:Serine Endopeptidases / Q000172:deficiency / Q000378:metabolism
chemical_list: D015816:Cell Adhesion Molecules, Neuronal; C103773:Dab1 protein, mouse; D016326:Extracellular Matrix Proteins; D026502:LDL-Receptor Related Proteins; D009419:Nerve Tissue Proteins; D011973:Receptors, LDL; D018110:Receptors, Lipoprotein; D000091042:Reelin Protein; C036053:VLDL receptor; C098773:low density lipoprotein receptor-related protein 8; C000717128:Reln protein, mouse; D012697:Serine Endopeptidases