title: Effects of obstructive sleep apnea on cognitive function: a comparison between younger and older OSAS patients.
abstract: OBJECTIVE
  Patients with obstructive sleep apnea syndrome (OSAS) present cognitive deficits similar to those observed with aging. The aim of the study was to assess the effects of age on cognitive functions in OSAS patients. It was hypothesized that older OSAS patients will exhibit significant cognitive dysfunction relative to younger OSAS patients and controls.
  
  
  METHODS
  Younger and older OSAS patients were compared to younger and older control subjects (age cut-off set at 50 yrs). Participants underwent a polysomnographic (PSG) and neuropsychological evaluation. Variables were analyzed by two-way analyses of variance (ANOVAs) with two factors: Group (control and OSAS) and Age (younger and older). Additionally, we evaluated the contribution of attentional deficits to cognitive dysfunction for each subgroup of patients by using Spearman correlation coefficients.
  
  
  RESULTS
  No Group-by-Age interaction was found for any neuropsychological variables (p<0.05). However, main Group and Age effects were found. Correlations indicated that attentional deficits contributed importantly to a poorer cognitive performance in younger OSAS patients only (p<0.01).
  
  
  CONCLUSIONS
  Our results are in agreement with those of the literature for both OSAS-related and aging-related cognitive deficits but did not demonstrate that age interacts with the effects of the OSAS condition to make those cognitive deficits worse.
authors.affiliation: Centre d'étude du sommeil et des rythmes biologiques, Hôpital du Sacré-Coeur de Montréal, 5400 boul. Gouin Ouest, Montréal, Que., Canada H4J 1C5.
authors.forename: A
authors.initials: A
authors.lastname: Mathieu
authors.forename: S
authors.initials: S
authors.lastname: Mazza
authors.forename: A
authors.initials: A
authors.lastname: Décary
authors.forename: J
authors.initials: J
authors.lastname: Massicotte-Marquez
authors.forename: D
authors.initials: D
authors.lastname: Petit
authors.forename: N
authors.initials: N
authors.lastname: Gosselin
authors.forename: J
authors.initials: J
authors.lastname: Malo
authors.forename: J
authors.initials: J
authors.lastname: Montplaisir
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology; D001288:Attention; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology*; D004569:Electroencephalography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D017286:Polysomnography; D011930:Reaction Time; D012720:Severity of Illness Index; D020181:Sleep Apnea, Obstructive / Q000150:complications* / Q000175:diagnosis