title: Sugar-assisted ligation for the synthesis of glycopeptides.
abstract: Chemical synthesis of glycoproteins from readily available materials is a powerful method for obtaining a pure product with full control of its atomic structure. Sugar-assisted ligation (SAL) is an emerging approach that allows the synthesis of a large glycopeptide from two unprotected fragments. Contrary to other ligation methods that are limited to the use of a cysteine residue or depend on external auxiliary, SAL takes advantage of the existing sugars in glycopeptides to promote proximity between the two peptides to facilitate an amide bond formation.
authors.affiliation: Department of Chemistry, Ben Gurion University, Beer Sheva, Israel. abrik@bgu.ac.il
authors.forename: Ashraf
authors.initials: A
authors.lastname: Brik
authors.forename: Chi-Huey
authors.initials: CH
authors.lastname: Wong
mesh_terms: D002240:Carbohydrate Sequence; D002241:Carbohydrates / Q000737:chemistry*; D006020:Glycopeptides / Q000138:chemical synthesis* / Q000737:chemistry; D008969:Molecular Sequence Data; D015394:Molecular Structure
chemical_list: D002241:Carbohydrates; D006020:Glycopeptides