Pregnancies complicated by multidrug-resistant tuberculosis and HIV co-infection in Durban, South Africa.
METHODS
Tertiary hospitals in KwaZulu Natal, South Africa.


OBJECTIVE
To study the impact of multidrug-resistant tuberculosis (MDR-TB) and human immunodeficiency virus-1 (HIV-1) co-infection during pregnancy on maternal and perinatal outcome.


METHODS
Prospective study performed between 1996 and 2001. Symptomatic pregnant women were investigated for TB. Those with confirmed MDR-TB were reported on.


RESULTS
Three of five pregnant women with MDR-TB were HIV-1 co-infected. One woman decided to terminate the pregnancy and one experienced pre-term labour. Two neonates had features of growth restriction.


CONCLUSIONS
Management of pregnant women with MDR-TB in an HIV-endemic area is possible in developing countries.
Khan
M
M
Centre for the AIDS Programme of Research in South Africa, Nelson R Mandela School of Medicine, University of KwaZulu Natal, Congella, Durban, KwaZulu Natal, South Africa. khanm18@ukzn.ac.za
Pillay
T
T
Moodley
J
J
Ramjee
A
A
Padayatchi
N
N
D000028:Abortion, Induced; D000022:Abortion, Spontaneous; D000293:Adolescent; D000328:Adult; D000995:Antitubercular Agents / Q000009:adverse effects; D005260:Female; D005317:Fetal Growth Retardation / Q000209:etiology; D015658:HIV Infections / Q000150:complications* / Q000175:diagnosis / Q000635:transmission / Q000821:virology; D015497:HIV-1; D006801:Humans; D018445:Infectious Disease Transmission, Vertical; D050498:Live Birth; D009169:Mycobacterium tuberculosis / Q000302:isolation & purification; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology / Q000821:virology; D011446:Prospective Studies; D013019:South Africa; D013183:Sputum / Q000382:microbiology; D018088:Tuberculosis, Multidrug-Resistant / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology / Q000635:transmission
D000995:Antitubercular Agents