Sugar-assisted ligation for the synthesis of glycopeptides.
Chemical synthesis of glycoproteins from readily available materials is a powerful method for obtaining a pure product with full control of its atomic structure. Sugar-assisted ligation (SAL) is an emerging approach that allows the synthesis of a large glycopeptide from two unprotected fragments. Contrary to other ligation methods that are limited to the use of a cysteine residue or depend on external auxiliary, SAL takes advantage of the existing sugars in glycopeptides to promote proximity between the two peptides to facilitate an amide bond formation.
Brik
Ashraf
A
Department of Chemistry, Ben Gurion University, Beer Sheva, Israel. abrik@bgu.ac.il
Wong
Chi-Huey
CH
D002240:Carbohydrate Sequence; D002241:Carbohydrates / Q000737:chemistry*; D006020:Glycopeptides / Q000138:chemical synthesis* / Q000737:chemistry; D008969:Molecular Sequence Data; D015394:Molecular Structure
D002241:Carbohydrates; D006020:Glycopeptides