Genetics of epilepsy: epilepsy research foundation workshop report.
The Sixth Epilepsy Research Foundation workshop, held in Oxford in March 2006, brought together basic scientists, geneticists, epidemiologists, statisticians, pharmacologists and clinicians to consider progress, issues and strategies for harnessing genetics to improve the understanding and treatment of the epilepsies. General principles were considered, including the fundamental importance of clear study design, adequate patient numbers, defi ned phenotypes, robust statistical data handling, and follow-up of genetic discoveries. Topics where some progress had been made were considered including chromosomal abnormalities, neurodevelopment, hippocampal sclerosis, juvenile myoclonic epilepsy, focal cortical dysplasia and pharmacogenetics. The ethical aspects of epilepsy genetics were reviewed. Principles and limitations of collaboration were discussed. Presentations and their matched discussions are produced here. There was optimism that further genetic research in epilepsy was not only feasible, but might lead to improvements in the lives of people with epilepsy.
Sisodiya
Sanjay
S
Epilepsy Research Foundation, United Kingdom.
Cross
J Helen
JH
Blümcke
Ingmar
I
Chadwick
David
D
Craig
John
J
Crino
Peter B
PB
Debenham
Paul
P
Delanty
Norman
N
Elmslie
Frances
F
Gardiner
Mark
M
Golden
Jeffrey
J
Goldstein
David
D
Greenberg
David A
DA
Guerrini
Renzo
R
Hanna
Michael
M
Harris
John
J
Harrison
Paul
P
Johnson
Michael R
MR
Kirov
George
G
Kullman
Dimitri M
DM
Makoff
Andrew
A
Marini
Carla
C
Nabbout
Rima
R
Nashef
Lina
L
Noebels
Jeffrey L
JL
Ottman
Ruth
R
Pirmohamed
Munir
M
Pitkänen
Asla
A
Scheffer
Ingrid
I
Shorvon
Simon
S
Sills
Graeme
G
Wood
Nicholas
N
Zuberi
Sameer
S
D000927:Anticonvulsants / Q000627:therapeutic use; D004827:Epilepsy / Q000188:drug therapy / Q000235:genetics*; D032984:Ethics, Research; D006801:Humans; D010597:Pharmacogenetics; D012107:Research Design / Q000592:standards
D000927:Anticonvulsants