title: Fibroblast growth factor 20 gene and Parkinson's disease in the Japanese population.
abstract: A genetic association between the fibroblast growth factor 20 (FGF20) gene and Parkinson's disease has been found by the pedigree disequilibrium test. This association, however, was not replicated by a case-control association study. In order to clarify the association between the FGF20 gene and Parkinson's disease, we attempted to replicate this association by a case-control association study using a large number of Japanese samples (1388 patients and 1891 controls). rs1721100 exhibited a significant difference in allele C versus G (P=0.0089), and in genotype CC+CG versus GG (P=0.0053). Haplotype association analysis showed that haplotype 2 was the protective haplotype for Parkinson's disease (permutation-P=0.0075). These results suggest that the FGF20 gene is a susceptibility gene for Parkinson's disease in the Japanese population.
authors.affiliation: Division of Clinical Genetics, Department of Medical Genetics, Osaka University Graduate School of Medicine, Yamadaoka, Suita, Osaka, Japan.
authors.forename: Wataru
authors.initials: W
authors.lastname: Satake
authors.forename: Ikuko
authors.initials: I
authors.lastname: Mizuta
authors.forename: Satoko
authors.initials: S
authors.lastname: Suzuki
authors.forename: Yuko
authors.initials: Y
authors.lastname: Nakabayashi
authors.forename: Chiyomi
authors.initials: C
authors.lastname: Ito
authors.forename: Masahiko
authors.initials: M
authors.lastname: Watanabe
authors.forename: Atsushi
authors.initials: A
authors.lastname: Takeda
authors.forename: Kazuko
authors.initials: K
authors.lastname: Hasegawa
authors.forename: Saburo
authors.initials: S
authors.lastname: Sakoda
authors.forename: Mitsutoshi
authors.initials: M
authors.lastname: Yamamoto
authors.forename: Nobutaka
authors.initials: N
authors.lastname: Hattori
authors.forename: Miho
authors.initials: M
authors.lastname: Murata
authors.forename: Tatsushi
authors.initials: T
authors.lastname: Toda
mesh_terms: D000368:Aged; D000483:Alleles; D016022:Case-Control Studies; D005260:Female; D005346:Fibroblast Growth Factors / Q000235:genetics*; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D007564:Japan / Q000453:epidemiology; D015810:Linkage Disequilibrium / Q000235:genetics; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000453:epidemiology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012306:Risk
chemical_list: D005346:Fibroblast Growth Factors