title: [Bacillus subtilis metabolites as a novel promising probiotic preparations].
abstract: Characteristics of Bacillus subtilis metabolites contained in supernatants of its broth cultures are described. Metabolites contained bacterium-produced biologically active components ensuring cells growth and propagation. These components had bacteriostatic and bactericidal effect on gram-positive and gram-negative pathogenic and conditionally pathogenic microflora of gastrointestinal tract of human and animals. Enzymes produced by the bacterium (amylase, protease, cellulose-decomposing enzyme, lipase, pectinase) increased antagonistic properties of preparation and promote its probiotic effect.
authors.forename: M Iu
authors.initials: MIu
authors.lastname: Volkov
authors.forename: E I
authors.initials: EI
authors.lastname: Tkachenko
authors.forename: E V
authors.initials: EV
authors.lastname: Vorobeĭchikov
authors.forename: A V
authors.initials: AV
authors.lastname: Sinitsa
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000378:metabolism / Q000494:pharmacology; D001412:Bacillus subtilis / Q000254:growth & development / Q000378:metabolism*; D001688:Biological Products / Q000032:analysis / Q000378:metabolism* / Q000494:pharmacology*; D017077:Culture Media, Conditioned / Q000378:metabolism / Q000494:pharmacology; D004798:Enzymes / Q000378:metabolism / Q000494:pharmacology; D005767:Gastrointestinal Diseases / Q000382:microbiology; D041981:Gastrointestinal Tract / Q000382:microbiology; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D051379:Mice; D008807:Mice, Inbred BALB C; D019936:Probiotics / Q000032:analysis / Q000378:metabolism* / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D001688:Biological Products; D017077:Culture Media, Conditioned; D004798:Enzymes