Concise review: Dendritic cell development in the context of the spleen microenvironment.
The dendritic cell (DC) population in spleen comprises a mixture of cells including endogenous DC progenitors, DC precursors migrating in from blood and bone marrow, and DC in different states of differentiation and activation. A role for different microenvironments in supporting the dynamic development of murine DC of different types or lineages is considered here. Recent evidence for production of DC dependent on splenic stromal cells is reviewed in the light of evidence that cell production is dependent on cells comprising an endothelial niche in spleen. The possibility that self-renewing progenitors in spleen give rise to DC with tolerogenic or regulatory rather than immunostimulatory function is considered.
Tan
Jonathan K H
JK
School of Biochemistry & Molecular Biology, The Australian National University, Canberra, Australian Capital Territory, Australia 0200.
O'Neill
Helen C
HC
D000818:Animals; D002454:Cell Differentiation; D019070:Cell Lineage / Q000502:physiology; D003713:Dendritic Cells / Q000166:cytology*; D015672:Erythroid Precursor Cells / Q000166:cytology; D006410:Hematopoiesis / Q000502:physiology; D006801:Humans; D008954:Models, Biological; D013154:Spleen / Q000166:cytology*; D017154:Stromal Cells / Q000502:physiology; D051941:fms-Like Tyrosine Kinase 3 / Q000502:physiology
C497971:Flt3 protein, mouse; D051941:fms-Like Tyrosine Kinase 3