Energy regulation: HIF MXIes it up with the C-MYC powerhouse.
The phenomenon of aerobic glycolysis observed in cancer cells has remained unexplained. In the May 2007 issue of Cancer Cell, Zhang and colleagues determine that the hypoxia-inducible factor family of transcriptional factors regulate mitochondrial biogenesis through inhibition of C-MYC.
Sutphin
Patrick D
PD
Department of Radiation Oncology, Stanford University, Stanford, CA 94305, USA.
Giaccia
Amato J
AJ
Chan
Denise A
DA
D051792:Basic Helix-Loop-Helix Proteins / Q000378:metabolism*; D004734:Energy Metabolism; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000378:metabolism*; D008928:Mitochondria / Q000378:metabolism*; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D010100:Oxygen / Q000378:metabolism; D016271:Proto-Oncogene Proteins c-myc / Q000037:antagonists & inhibitors* / Q000502:physiology; D014158:Transcription, Genetic / Q000502:physiology; D025521:Tumor Suppressor Proteins / Q000378:metabolism*; D051794:Von Hippel-Lindau Tumor Suppressor Protein / Q000378:metabolism
D051792:Basic Helix-Loop-Helix Proteins; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D010100:Oxygen; D016271:Proto-Oncogene Proteins c-myc; D025521:Tumor Suppressor Proteins; D051794:Von Hippel-Lindau Tumor Suppressor Protein; C497442:HIF1A protein, human; C079440:MXI1 protein, human; C497446:VHL protein, human