Changes in qnr prevalence and fluoroquinolone resistance in clinical isolates of Klebsiella pneumoniae and Enterobacter spp. collected from 1990 to 2005.
Clinical isolates of Klebsiella pneumoniae and Enterobacter spp. collected from 1990 through 2005 at a tertiary care center were studied for qnr genes. Isolates bearing these genes emerged in the mid-1990s, coinciding with the time of a rapid increase in fluoroquinolone resistance. Sixty percent of these isolates were ciprofloxacin susceptible by CLSI breakpoints.
Strahilevitz
Jacob
J
Department of Clinical Microbiology and Infectious Diseases, Hadassah Ein-Kerem, Jerusalem, Israel. jstrahilevitz@hadassah.org.il
Engelstein
Dalia
D
Adler
Amos
A
Temper
Violeta
V
Moses
Allon E
AE
Block
Colin
C
Robicsek
Ari
A
D000890:Anti-Infective Agents / Q000494:pharmacology*; D016470:Bacteremia / Q000453:epidemiology* / Q000382:microbiology; D001426:Bacterial Proteins / Q000235:genetics*; D002939:Ciprofloxacin / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial / Q000235:genetics; D004754:Enterobacter / Q000145:classification / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification; D004756:Enterobacteriaceae Infections / Q000453:epidemiology / Q000382:microbiology; D006801:Humans; D007557:Israel / Q000453:epidemiology; D007710:Klebsiella Infections / Q000453:epidemiology / Q000382:microbiology; D007711:Klebsiella pneumoniae / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification; D008826:Microbial Sensitivity Tests / Q000592:standards; D015995:Prevalence
D000890:Anti-Infective Agents; D001426:Bacterial Proteins; C485385:Qnr protein, Klebsiella pneumoniae; D002939:Ciprofloxacin