title: Idiopathic hypereosinophilic syndrome presenting acute abdomen.
abstract: We describe a 27-year-old man with hypereosinophilc syndrome (HES) presenting acute abdomen due to acute thrombosis of the mesenteric artery, who had a past history of eosinophilic pneumonia followed by multiple arterial thromboses of the extremities. At the recurrence of eosinophilia, he was treated with high-dose corticosteroids. Immediately after the reduction of peripheral blood eosinophils, he suddenly developed perforation of the intestine due to acute thromboses of mesenteric arteries despite sustained anticoagulation therapy. Molecular analysis demonstrated that the FIP1L1-PDGFRA fusion gene was negative. Histopathology showed thrombi and eosinophilic inflammation of arteries. It is important to recognize that HES could be a cause of acute abdomen.
authors.affiliation: Department of Hematology and Respiratory Medicine, Kochi Medical School, Kochi University, Nankoku, Japan. kmakoto@med.kochi-u.ac.jp
authors.forename: Makoto
authors.initials: M
authors.lastname: Kobayashi
authors.forename: Naoki
authors.initials: N
authors.lastname: Komatsu
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Kuwayama
authors.forename: Kentaro
authors.initials: K
authors.lastname: Bandobashi
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Kubota
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Uemura
authors.forename: Hirokuni
authors.initials: H
authors.lastname: Taguchi
mesh_terms: D000006:Abdomen, Acute / Q000209:etiology* / Q000601:surgery; D000328:Adult; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000150:complications* / Q000188:drug therapy; D008297:Male; D008638:Mesenteric Arteries / Q000473:pathology*; D008775:Methylprednisolone / Q000627:therapeutic use; D013927:Thrombosis / Q000209:etiology*
chemical_list: D005938:Glucocorticoids; D008775:Methylprednisolone