title: Influence of rifampin on capsule formation around silicone implants in a rat model.
abstract: This study investigated the effect of rifampin on the thickness of capsules around silicone implants by bactericidal activity against Stapylococcus epidermidis. Silicone blocks (1 x 1 cm) were placed into pockets created for each of the 40 rats included in the study. In group 1, the operation was performed under aseptic conditions. In group 2, standard S. epidermidis was inoculated into the pocket, whereas rifampin and S. epidermidis were applied in group 3. In group 4, only rifampin was applied topically on implants. After 12 weeks, the peri-implant capsules were removed and examined under a photomicroscope and a scanning electron microscope. The mean thickness of the capsules was 63.307 microm in group 1, 111.538 microm in group 2, 43.076 microm in group 3, and 30.384 mum in group 4. The differences between groups 2 and 3 and groups 2 and 4 were found to be statistically significant (p < 0.001). Rifampin appears to be an agent for preventing peri-implant capsule formation.
authors.affiliation: Department of 2nd Plastic and Reconstructive Surgery, Ankara Numune Training and Research Hospital, Ankara, Turkey.
authors.forename: Ramazan Erkin
authors.initials: RE
authors.lastname: Unlu
authors.forename: Asu Deniz
authors.initials: AD
authors.lastname: Yilmaz
authors.forename: Hakan
authors.initials: H
authors.lastname: Orbay
authors.forename: Belgin
authors.initials: B
authors.lastname: Can
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Tekdemir
authors.forename: Omer
authors.initials: O
authors.lastname: Sensoz
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D005260:Female; D005549:Foreign-Body Reaction / Q000188:drug therapy* / Q000382:microbiology; D008297:Male; D023421:Models, Animal; D019736:Prostheses and Implants / Q000009:adverse effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D012293:Rifampin / Q000008:administration & dosage*; D012828:Silicones / Q000009:adverse effects*; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000382:microbiology; D013212:Staphylococcus epidermidis / Q000302:isolation & purification; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D012828:Silicones; D012293:Rifampin