title: New catalysts for Suzuki-Miyaura coupling reactions of heteroatom-substituted heteroaryl chlorides.
abstract: The new air-stable PdCl2[PR2(Ph-R')]2 complexes, readily prepared from commercial reagents, exhibit unique efficiency as catalysts for the Suzuki-Miyaura coupling reactions of a variety of heteroatom-substituted heteroaryl chlorides with a diverse range of aryl/heteroaryl boronic acids. The coupling reactions catalyzed by the new complexes exhibit high product yields (88-99%) and high catalyst turnover numbers (up to 10,000 TON).
authors.affiliation: Chemistry Research and Discovery, Amgen Inc., Thousand Oaks, California 91320-1799, USA. aguram@amgen.com
authors.forename: Anil S
authors.initials: AS
authors.lastname: Guram
authors.forename: Xiang
authors.initials: X
authors.lastname: Wang
authors.forename: Emilio E
authors.initials: EE
authors.lastname: Bunel
authors.forename: Margaret M
authors.initials: MM
authors.lastname: Faul
authors.forename: Robert D
authors.initials: RD
authors.lastname: Larsen
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Martinelli