Primary progressive multiple sclerosis: a comparative study of the diagnostic criteria.
We assessed the different sets of diagnostic criteria for primary progressive multiple sclerosis (PPMS), in order to determine their sensitivity when applied to a cohort of 261 PPMS patients. According to the Thompson criteria, 168 patients (64.4%) had definite PPMS, 84 patients (32.2%) had probable PPMS, and nine patients (3.4%) had possible PPMS; according to the McDonald criteria, 180 patients (69%) had PPMS; according to the revised McDonald criteria, 194 patients (74.3%) had PPMS. Our findings indicate that the revised McDonald criteria are more sensitive than the original McDonald criteria, but less sensitive than the Thompson criteria.
de Seze
J
J
Department of Neurology, Hôpital Civil, Strasbourg, France. jerome.de.seze@chru-strasbourg.fr
Debouverie
M
M
Waucquier
N
N
Steinmetz
G
G
Pittion
S
S
Zephir
H
H
Fleury
M
M
Blanc
F
F
Vermersch
P
P
D000328:Adult; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D020528:Multiple Sclerosis, Chronic Progressive / Q000145:classification* / Q000175:diagnosis*; D017410:Practice Guidelines as Topic; D012189:Retrospective Studies; D012680:Sensitivity and Specificity