title: Cutaneous leishmaniasis reactivation 2 years after treatment caused by systemic corticosteroids - first report.
abstract: American tegumentary leishmaniasis (ATL), an endemic anthropozoonosis in various countries in the world, is caused by parasites of the genus Leishmania. Despite reports on ATL reactivation as a result of immunosuppression, to the best of our knowledge, this paper describes the first case of ATL reactivation in its localized form (cutaneous leishmaniasis) associated with the administration of systemic corticosteroids. The possible action of corticosteroids on the host immune response to the parasite in patients with localized cutaneous leishmaniasis is discussed. This report demonstrates the possibility of ATL reactivation in patients using corticosteroids, an observation that should be considered in individuals treated with this medication.
authors.affiliation: Infectious and Parasitic Diseases Clinic, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, Brazil. ffbt@pop.com.br
authors.forename: Felipe Francisco
authors.initials: FF
authors.lastname: Tuon
authors.forename: Valdir
authors.initials: V
authors.lastname: Sabbaga Amato
authors.forename: Lucile Maria
authors.initials: LM
authors.lastname: Floeter-Winter
authors.forename: Ricardo
authors.initials: R
authors.lastname: de Andrade Zampieri
authors.forename: Vicente
authors.initials: V
authors.lastname: Amato Neto
authors.forename: Francisco Oscar
authors.initials: FO
authors.lastname: Siqueira França
authors.forename: Maria Aparecida
authors.initials: MA
authors.lastname: Shikanai-Yasuda
mesh_terms: D000305:Adrenal Cortex Hormones / Q000009:adverse effects*; D000328:Adult; D000818:Animals; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D007165:Immunosuppression Therapy / Q000009:adverse effects*; D007894:Leishmania mexicana / Q000302:isolation & purification*; D016773:Leishmaniasis, Cutaneous / Q000209:etiology* / Q000473:pathology; D009894:Opportunistic Infections / Q000209:etiology* / Q000473:pathology; D012008:Recurrence; D012867:Skin / Q000469:parasitology* / Q000473:pathology
chemical_list: D000305:Adrenal Cortex Hormones