title: Safety of and tolerance to adenosine infusion for myocardial perfusion single-photon emission computed tomography in a Japanese population.
abstract: BACKGROUND
  Adenosine has been available for use in myocardial perfusion single-photon emission computed tomography (SPECT) in Japan since 2005. The purpose of this study was to evaluate the safety of and tolerance to thallium-201 myocardial perfusion SPECT with intravenous adenosine infusion in Japanese patients with suspected coronary artery disease.
  
  
  RESULTS
  Two hundred and six consecutive patients who underwent an adenosine infusion (120 mug . kg(-1) . min(-1)) SPECT at Sumitomo Besshi Hospital (Niihama, Japan) were investigated. The effects of adenosine infusion were monitored for each patient. A coronary angiography was performed in 81 patients. Adenosine infusion significantly decreased blood pressure and increased heart rate. Adverse reactions were observed in 161 patients (78.2%). Most reactions were transient, disappearing soon after the termination of adenosine infusion. No serious adverse reactions, such as acute myocardial infarction or death, occurred. Adenosine infusion was terminated in 3 patients (1.5%) because of near syncope or sustained 2:1 atrioventricular block. Electrocardiographic changes occurred in 15 patients (7.3%). Self-assessed scoring after SPECT showed that the patients were very tolerant (74.6% of 177 patients) of adenosine infusion myocardial SPECT. The sensitivity and specificity were 75.0% and 69.7%, respectively.
  
  
  CONCLUSIONS
  Adenosine infusion myocardial SPECT is safe and well tolerated in the Japanese population, despite the frequent occurrence of minor adverse reactions.
authors.affiliation: Division of Cardiology, Sumitomo Besshi Hospital, Niihama, Japan.
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Hatanaka
authors.forename: Masayuki
authors.initials: M
authors.lastname: Doi
authors.forename: Satoshi
authors.initials: S
authors.lastname: Hirohata
authors.forename: Shigeshi
authors.initials: S
authors.lastname: Kamikawa
authors.forename: Yoko
authors.initials: Y
authors.lastname: Kaji
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Katoh
authors.forename: Shozo
authors.initials: S
authors.lastname: Kusachi
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Ninomiya
authors.forename: Tohru
authors.initials: T
authors.lastname: Ohe
mesh_terms: D000241:Adenosine / Q000009:adverse effects / Q000494:pharmacology*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D054537:Atrioventricular Block / Q000139:chemically induced / Q000000981:diagnostic imaging / Q000503:physiopathology; D001794:Blood Pressure / Q000187:drug effects; D003324:Coronary Artery Disease / Q000150:complications / Q000000981:diagnostic imaging* / Q000503:physiopathology; D004562:Electrocardiography; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007262:Infusions, Intravenous; D007564:Japan; D008297:Male; D008875:Middle Aged; D011859:Radiography; D013575:Syncope / Q000139:chemically induced / Q000000981:diagnostic imaging / Q000503:physiopathology; D013794:Thallium Radioisotopes / Q000009:adverse effects; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D013794:Thallium Radioisotopes; D000241:Adenosine