title: Low frequency repetitive transcranial magnetic stimulation over premotor cortex can improve cortical tremor.
abstract: OBJECTIVE
  To examine the effects of a 30 min, 1 Hz subthreshold rTMS in a case of cortical tremor which is caused by hyperexcitability of sensorimotor cortex.
  
  
  METHODS
  Stimulation was applied over primary and, in a second time, over premotor cortex (M1 and PMC, respectively). Tremor was monitored by accelerometers placed on the index fingers of hands outstretched, before and several times after rTMS. Each rTMS session consisted of 1800 pulses delivered at 1 Hz with an intensity of 90% of resting motor threshold.
  
  
  RESULTS
  PMC but not M1 stimulation led to a decrease of the postural tremor (90% decrease of acceleration total spectral power). This functional benefit was associated to normalization of electrophysiologic parameters (short-interval intracortical inhibition and cortical silent period duration). Moreover, when stimulating PMC during two daily sessions, improvement of the tremor was longer than one day stimulation and this benefit was associated with functional improvement.
  
  
  CONCLUSIONS
  This study shows that 1 Hz rTMS over premotor cortex can improve cortical tremor.
  
  
  CONCLUSIONS
  These results raise the interest of the motor cortical stimulation as a possible therapeutic target for treatment of action tremor.
authors.affiliation: Departement de Neurophysiologie Clinique, Hôpital Roger Salengro, Centre Hospitalier Régional Universitaire, EA 2683, CHRU 59037 Lille cedex, France.
authors.forename: E
authors.initials: E
authors.lastname: Houdayer
authors.forename: H
authors.initials: H
authors.lastname: Devanne
authors.forename: L
authors.initials: L
authors.lastname: Tyvaert
authors.forename: L
authors.initials: L
authors.lastname: Defebvre
authors.forename: P
authors.initials: P
authors.lastname: Derambure
authors.forename: F
authors.initials: F
authors.lastname: Cassim
mesh_terms: D000328:Adult; D004569:Electroencephalography; D004576:Electromyography; D005260:Female; D005385:Fingers / Q000294:innervation / Q000502:physiology; D006801:Humans; D009044:Motor Cortex / Q000502:physiology*; D009207:Myoclonus / Q000628:therapy; D011597:Psychomotor Performance; D013003:Somatosensory Cortex / Q000502:physiology; D050781:Transcranial Magnetic Stimulation; D014202:Tremor / Q000628:therapy*