title: [Expression of hypoxia-inducible factor-1alpha in endometriosis].
abstract: OBJECTIVE
  To detect the expression of hypoxia-inducible factor-1alpha(HIF-1alpha) in endometriosis and explore the possible role of HIF-1alpha in the pathogenesis of endometriosis.
  
  
  METHODS
  Immunohistochemistry was performed to examine the expression of HIF-1alpha in 20 normal endometrium, 20 ectopic endometrium and 68 eutopic endometrium specimens from 68 endometriosis patients, and the results were analyzed statistically.
  
  
  RESULTS
  The expression of HIF-1alpha was significantly increased in ectopic endometrium than in normal endometrium (P<0.01), and the expression did not undergo changes with the normal menstrual cycle in the three types of endometrium.
  
  
  CONCLUSIONS
  HIF-1alpha expression increases in ectopic endometrium, suggesting that HIF-1alpha plays an important role in the pathogenesis of endometriosis.
authors.affiliation: Department of Obstetrics and Gynecology, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China. renxu@fimmu.com
authors.forename: Xu
authors.initials: X
authors.lastname: Ren
authors.forename: Yuan-li
authors.initials: YL
authors.lastname: He
authors.forename: Shi-lei
authors.initials: SL
authors.lastname: Pan
authors.forename: Dong-xian
authors.initials: DX
authors.lastname: Peng
mesh_terms: D000328:Adult; D004715:Endometriosis / Q000235:genetics*; D004717:Endometrium / Q000378:metabolism*; D005260:Female; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000235:genetics* / Q000378:metabolism; D008597:Menstrual Cycle / Q000378:metabolism
chemical_list: D051795:Hypoxia-Inducible Factor 1, alpha Subunit