[Hypercalcaemia and malignant lymphoma. One case report].
Hypercalcaemia occurs in less than 15% of lymphomas but is associated with a poor prognosis. A patient known to have a testicular lymphoma was admitted because of asthenia and weight loss. Hypercalcemia and high serum level of calcitriol were found. A high-grade lymphoma attesting a Richter's syndrome was diagnosed. Palliative treatment consisting in corticosteroids and pamidronate was instituted. Hypercalcaemia in lymphoma has a poor prognosis and is often attributed to an acquired uncontrolled vitamin D 1-alpha-hydroxylase activity by the macrophages close to the lymphomatous cells. Influences of TNFalpha, interleukine 6 and PTHrp are also reported.
Frein
D
D
Département de médecine interne et gérontologie clinique, 4 rue Larrey, 49000 Angers, France. freindoro@wanadoo.fr
Lavigne
C
C
Josselin
N
N
Foussard
C
C
Sivova
N
N
Moles
M-P
MP
Berrut
G
G
D000369:Aged, 80 and over; D050071:Bone Density Conservation Agents / Q000627:therapeutic use; D002117:Calcitriol / Q000097:blood; D004164:Diphosphonates / Q000627:therapeutic use; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology*; D008228:Lymphoma, Non-Hodgkin / Q000150:complications*; D008297:Male; D010166:Palliative Care; D000077268:Pamidronate; D011241:Prednisone / Q000627:therapeutic use; D013736:Testicular Neoplasms / Q000150:complications*
D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D005938:Glucocorticoids; D002117:Calcitriol; D000077268:Pamidronate; D011241:Prednisone