title: Praziquantel derivatives I: Modification of the aromatic ring.
abstract: Several analogues of the potent anthelmintic praziquantel were prepared with variation in the aromatic ring. The biological activity of these analogues was evaluated and compared against known analogues. Amination of the ring was tolerated while other variations were not. These results have important implications for drug development for schistosomiasis.
authors.affiliation: School of Biological and Chemical Sciences, Queen Mary, University of London, E1 4NS, UK.
authors.forename: Fiona
authors.initials: F
authors.lastname: Ronketti
authors.forename: A Venkata
authors.initials: AV
authors.lastname: Ramana
authors.forename: Xia
authors.initials: X
authors.lastname: Chao-Ming
authors.forename: Livia
authors.initials: L
authors.lastname: Pica-Mattoccia
authors.forename: Donato
authors.initials: D
authors.lastname: Cioli
authors.forename: Matthew H
authors.initials: MH
authors.lastname: Todd
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000737:chemistry* / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D009682:Magnetic Resonance Spectroscopy; D011223:Praziquantel / Q000031:analogs & derivatives* / Q000494:pharmacology; D012550:Schistosoma mansoni / Q000187:drug effects
chemical_list: D000871:Anthelmintics; D011223:Praziquantel