Influence of rifampin on capsule formation around silicone implants in a rat model.
This study investigated the effect of rifampin on the thickness of capsules around silicone implants by bactericidal activity against Stapylococcus epidermidis. Silicone blocks (1 x 1 cm) were placed into pockets created for each of the 40 rats included in the study. In group 1, the operation was performed under aseptic conditions. In group 2, standard S. epidermidis was inoculated into the pocket, whereas rifampin and S. epidermidis were applied in group 3. In group 4, only rifampin was applied topically on implants. After 12 weeks, the peri-implant capsules were removed and examined under a photomicroscope and a scanning electron microscope. The mean thickness of the capsules was 63.307 microm in group 1, 111.538 microm in group 2, 43.076 microm in group 3, and 30.384 mum in group 4. The differences between groups 2 and 3 and groups 2 and 4 were found to be statistically significant (p < 0.001). Rifampin appears to be an agent for preventing peri-implant capsule formation.
Unlu
Ramazan Erkin
RE
Department of 2nd Plastic and Reconstructive Surgery, Ankara Numune Training and Research Hospital, Ankara, Turkey.
Yilmaz
Asu Deniz
AD
Orbay
Hakan
H
Can
Belgin
B
Tekdemir
Ibrahim
I
Sensoz
Omer
O
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D005260:Female; D005549:Foreign-Body Reaction / Q000188:drug therapy* / Q000382:microbiology; D008297:Male; D023421:Models, Animal; D019736:Prostheses and Implants / Q000009:adverse effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D012293:Rifampin / Q000008:administration & dosage*; D012828:Silicones / Q000009:adverse effects*; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000382:microbiology; D013212:Staphylococcus epidermidis / Q000302:isolation & purification; D016896:Treatment Outcome
D000900:Anti-Bacterial Agents; D012828:Silicones; D012293:Rifampin