[Multimuscle treatment of spasticity in adults patients with botulinum toxin].
Some recent studies in children with spasticity demonstrated the safety of multimuscle injections of botulinum toxin (BT) type A with doses markedly higher than those recommended. Data about efficacy and safety of multifocal injections of BT in adult patients with spasticity are very limited. However numerous clinical situations for example, spinal cord injury, multiple sclerosis, brain injury, stroke or cerebral palsy seem to justify this type of patient management. Controlled studies are expected in the future to evaluate the efficacy and safety of multisite injections of BT. They may encourage physicians to perform such multifocal injections with high doses of BT. A better understanding of distant spread of BT is also warranted.
Bensmail
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D
Service de Médecine Physique et Réadaptation, Hôpital R. Poincaré, AP-HP, Université de Versailles-Saint-Quentin, 104 Bd R. Poincaré, 92380 Garches, France. djamel.bensmail@rpc.aphp.fr
Roche
N
N
D000328:Adult; D019274:Botulinum Toxins, Type A / Q000627:therapeutic use*; D006801:Humans; D007273:Injections, Intramuscular; D009128:Muscle Spasticity / Q000188:drug therapy*; D009465:Neuromuscular Agents / Q000627:therapeutic use*
D009465:Neuromuscular Agents; D019274:Botulinum Toxins, Type A