title: Potent macrocyclic antagonists to the motilin receptor presenting novel unnatural amino acids.
abstract: Novel, potent small molecule motilin receptor antagonists are described. These peptidomimetic macrocycles are composed of a tripeptide cyclized backbone-to-backbone with a nonpeptidic tether and bear new unnatural amino acids containing basic side chains.
authors.affiliation: Tranzyme Pharma Inc. 3001, 12e av Nord, Sherbrooke, PQ, Canada J1H5N4. emarsault@tranzyme.com
authors.forename: Eric
authors.initials: E
authors.lastname: Marsault
authors.forename: Kamel
authors.initials: K
authors.lastname: Benakli
authors.forename: Sylvie
authors.initials: S
authors.lastname: Beaubien
authors.forename: Carl
authors.initials: C
authors.lastname: Saint-Louis
authors.forename: Robert
authors.initials: R
authors.lastname: Déziel
authors.forename: Graeme
authors.initials: G
authors.lastname: Fraser
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D003500:Cyclization; D047028:Macrocyclic Compounds / Q000494:pharmacology*; D011964:Receptors, Gastrointestinal Hormone / Q000037:antagonists & inhibitors* / Q000737:chemistry; D018013:Receptors, Neuropeptide / Q000037:antagonists & inhibitors* / Q000737:chemistry
chemical_list: D000596:Amino Acids; D047028:Macrocyclic Compounds; D011964:Receptors, Gastrointestinal Hormone; D018013:Receptors, Neuropeptide; C050802:motilin receptor