Sphingolipids with neuritogenic activity from Euphorbia sororia.
Two groups of sphingolipids 1 and 2 were isolated from the aerial parts of Euphorbia sororia. On the basis of spectroscopic data, chemical methods and GC-MS analysis, the structures of 1 and 2 were characterized as 1-O-beta-D-glucopyranosyl-(2S,3S,4R,8Z)-2-[(2'R)-2'-hydroxydocosanoyl approximately hexacosanoyl, octacosanoyl amino]-1,3,4-octadecanetriol-8-ene and (2S,3S,4R,8E)-2-[(2'R)-2'-hydroxyeicosanoyl approximately hexacosanoyl amino]-1,3,4-octadecanetriol-8-ene, respectively. Both of them exhibited marked neuritogenic activity on the rat pheochromocytoma PC12 cell line.
Zhang
Wei-Ku
WK
Department of Phytochemistry, China Pharmaceutical University, Nanjing 210009, China.
Xu
Jie-Kun
JK
Zhang
Xiao-Qi
XQ
Yao
Xin-Sheng
XS
Ye
Wen-Cai
WC
D000818:Animals; D002460:Cell Line / Q000187:drug effects; D028481:Euphorbia / Q000737:chemistry*; D008401:Gas Chromatography-Mass Spectrometry; D016501:Neurites / Q000187:drug effects* / Q000378:metabolism; D016716:PC12 Cells; D051381:Rats; D013057:Spectrum Analysis; D013107:Sphingolipids / Q000302:isolation & purification / Q000494:pharmacology*; D013997:Time Factors
D013107:Sphingolipids