title: [Epidemiological study on the Genetics and Environment of Asthma, bronchial hyperresponsiveness and atopy (EGEA) - First results of a multi-disciplinary study].
abstract: The French co-operative epidemiological study EGEA realised in 1991/95 combines a case control study and a study of the families of asthmatic cases. A synthesis of the results already obtained is presented. Smoking was related to IgE, even in asthmatics and was clearly related to the clinical severity of asthma, an aspect insufficiently taken into account. The relationships of occupational exposures to asthma have been assessed using a job exposure matrix. Segregation analyses on IgE have shown, after correction for the mode of ascertainment, the existence of a dominant major gene and familial residual correlation. A systematic genome screen realised in families with 2 asthmatic siblings showed linkage of various regions in the genome implicated to asthma or related phenotypes (1p, 11p, 11q, 12q, 13q, 17q, 19q), coherent with genome screens realised in other studies. Regarding candidate genes, no association was evidenced between asthma and the AF508 mutation of the cystic fibrosis gene. The analysis is still in progress by studies on the heterogeneity of asthma with refined genetic studies and by searching to integrate results regarding environmental and genetic factors and studying their interactions.
authors.affiliation: INSERM U 472, Villejuif, France. kauffmann@vjf.inserm.fr
authors.forename: F
authors.initials: F
authors.lastname: Kauffmann
authors.forename: M H
authors.initials: MH
authors.lastname: Dizier
authors.forename: M P
authors.initials: MP
authors.lastname: Oryszczyn
authors.forename: N
authors.initials: N
authors.lastname: Le Moual
authors.forename: V
authors.initials: V
authors.lastname: Siroux
authors.forename: S
authors.initials: S
authors.lastname: Kennedy
authors.forename: I
authors.initials: I
authors.lastname: Annesi-Maesano
authors.forename: J
authors.initials: J
authors.lastname: Bousquet
authors.forename: D
authors.initials: D
authors.lastname: Charpin
authors.forename: J
authors.initials: J
authors.lastname: Feingold
authors.forename: F
authors.initials: F
authors.lastname: Gormand
authors.forename: A
authors.initials: A
authors.lastname: Grimfeld
authors.forename: J
authors.initials: J
authors.lastname: Hochez
authors.forename: M
authors.initials: M
authors.lastname: Lathrop
authors.forename: R
authors.initials: R
authors.lastname: Matran
authors.forename: F
authors.initials: F
authors.lastname: Neukirch
authors.forename: E
authors.initials: E
authors.lastname: Paty
authors.forename: I
authors.initials: I
authors.lastname: Pin
authors.forename: F
authors.initials: F
authors.lastname: Demenais
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001249:Asthma / Q000453:epidemiology* / Q000209:etiology*; D016022:Case-Control Studies; D002648:Child; D004777:Environment; D005260:Female; D005602:France / Q000453:epidemiology; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D012720:Severity of Illness Index