Botulinum neurotoxin A: an unusual systemic effect.
Systemic effects from Botulinum neurotoxin A are uncommon but can have serious consequences. We report the case of a boy with severe cerebral palsy who developed deterioration in respiratory and oromotor function following repeated injections of Botulinum neurotoxin A. Caution is needed in using this treatment in children with severe cerebral palsy and pseudobulbar palsy.
Howell
Katherine
K
Department of Child Development and Rehabilitation, Royal Children's Hospital, Parkville, Victoria, Australia.
Selber
Paulo
P
Graham
H Kerr
HK
Reddihough
Dinah
D
D019274:Botulinum Toxins, Type A / Q000009:adverse effects* / Q000627:therapeutic use; D002547:Cerebral Palsy / Q000150:complications*; D002648:Child; D003680:Deglutition Disorders / Q000209:etiology; D006801:Humans; D008297:Male; D009465:Neuromuscular Agents / Q000009:adverse effects* / Q000627:therapeutic use; D020828:Pseudobulbar Palsy / Q000188:drug therapy*; D012135:Respiratory Sounds / Q000209:etiology
D009465:Neuromuscular Agents; D019274:Botulinum Toxins, Type A