Synthesis of some novel 2,4-disubstituted thiazoles as possible antimicrobial agents.
A series of novel 4-aryl/chloroalkyl-2-(2,3,5-trichlorophenyl)-1,3-thiazoles (5a-g and 7a-e) were synthesized by condensing 2,3,5-trichlorobenzenecarbothioamide with phenacyl bromide/dichloroacetone. 2,3,5-Trichlorobenzaldehyde thiosemicarbazone on treatment with phenacyl bromide afforded 4-aryl-2-(2,3,5-trichlorophenylidenehydrazino)-1,3-thiazoles (10a-g) in good yield. The newly synthesized compounds are characterized by IR, (1)H NMR and mass spectral studies. These compounds were also screened for their antibacterial and antifungal activities. Preliminary results reveal that some of the synthesized compounds are showing promising antimicrobial activity.
Karegoudar
Prakash
P
Department of Chemistry, Mangalore University, Mangalagangothri, Konaje, Mangalore, Karnataka 574199, India.
Karthikeyan
Mari Sithambaram
MS
Prasad
Dasappa Jagadeesh
DJ
Mahalinga
Manjathuru
M
Holla
Bantwal Shivarama
BS
Kumari
Nalilu Sucheta
NS
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013055:Spectrophotometry, Infrared; D013844:Thiazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D013844:Thiazoles