title: No association between coding polymorphism within Exon 4 of the human surfactant protein B gene and pulmonary function in healthy men.
abstract: The coding polymorphism (rs1130866) within the surfactant protein B gene is known to associate with certain respiratory abnormalities. We investigated, using spirometry and fluorescence-based PCR, whether this variant influenced pulmonary function in healthy, nonsmoking men. We found no association of pulmonary function with genotype at the rs1130866 locus.
authors.affiliation: The Biomedical Research Group, Division of Health and Life Sciences, The University of Northampton, UK. stuart.raleigh@northampton.ac.uk
authors.forename: Stuart M
authors.initials: SM
authors.lastname: Raleigh
authors.forename: Benjamin M
authors.initials: BM
authors.lastname: Davies
authors.forename: David
authors.initials: D
authors.lastname: Cleal
authors.forename: William J
authors.initials: WJ
authors.lastname: Ribbans
mesh_terms: D000328:Adult; D015331:Cohort Studies; D005091:Exons; D005541:Forced Expiratory Volume / Q000235:genetics; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000502:physiology*; D037701:Pulmonary Surfactant-Associated Protein B / Q000235:genetics / Q000502:physiology; D011663:Pulmonary Surfactants / Q000378:metabolism; D012123:Pulmonary Ventilation / Q000235:genetics*; D014797:Vital Capacity / Q000235:genetics
chemical_list: D037701:Pulmonary Surfactant-Associated Protein B; D011663:Pulmonary Surfactants