title: Why men's hearts break: cardiovascular effects of sex steroids.
abstract: Coronary artery disease (CAD) mortality differs in men and women, leading to the speculation that differences in sex steroids contribute to risk. Controlled clinical trials have shown that estrogen replacement is not cardioprotective in certain women, and recent cross-sectional studies associate low testosterone with a greater incidence of CAD in men. Testosterone has demonstrated effects on insulin resistance, obesity, myocardium, coagulation, inflammation, vasodilation, and endothelial function. Imbalance of sex steroids contributes to adverse cardiac effects in men.
authors.affiliation: The Zena and Michael A. Wiener Cardiovascular Institute, The Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1030, New York, NY 10029, USA.
authors.forename: Brian G
authors.initials: BG
authors.lastname: Choi
authors.forename: Mary Ann
authors.initials: MA
authors.lastname: McLaughlin
mesh_terms: D001777:Blood Coagulation / Q000502:physiology; D003324:Coronary Artery Disease / Q000453:epidemiology / Q000209:etiology* / Q000473:pathology; D004730:Endothelium, Vascular / Q000502:physiology / Q000503:physiopathology; D012739:Gonadal Steroid Hormones / Q000097:blood / Q000502:physiology*; D006801:Humans; D007006:Hypogonadism / Q000378:metabolism; D007249:Inflammation / Q000150:complications; D008297:Male; D009206:Myocardium / Q000473:pathology; D009765:Obesity / Q000097:blood / Q000150:complications; D013739:Testosterone / Q000097:blood / Q000494:pharmacology; D013927:Thrombosis / Q000097:blood / Q000209:etiology
chemical_list: D012739:Gonadal Steroid Hormones; D013739:Testosterone