Dehydroepiandrosterone behavior and lipid profile in non-obese women undergoing abdominoplasty.
BACKGROUND
The aim of this study was to determine any change in dehydroepiandrosterone (DHEA) and lipid profile in non-obese women after abdominoplasty.


METHODS
An auto-controlled clinical trial was carried out. 9 women aged 35 to 40 years with BMI 22-25 kg/m2 were studied. Basal lipid profile and DHEA were performed and repeated 1 month postoperatively. Statistical analysis used Wilcoxon signed-ranks test (two-tailed).


RESULTS
Weight of resected specimen was 606.11 +/- 143.4 grams. No significant changes were observed in high-density cholesterol (48.0 +/- 9.6 vs 48.8 +/- 11.0 mg/dl; P=0.106) or in triglycerides (119.2 +/- 50.9 vs 148.4 +/- 45.8 mg/dl; P = 0.139). Significant increases were obtained in DHEA (3.69 +/- 3.05 vs 11.09 +/- 6.3 ng/ml; P<0.008), low-density cholesterol (LDL) (87.4 +/- 23.5 vs 108.5 +/- 28.3 mg/dl; P<0.008 and total cholesterol (155.1 +/- 30.6 vs 186.6 +/- 33.1 mg/dl; P<0.008).


CONCLUSIONS
Excision of subcutaneous abdominal fat in studies 1 month later increased DHEA, whose role is controversial in visceral fat distribution, and increased LDL cholesterol and total cholesterol, both risk markers for cardiovascular illness.
Robles-Cervantes
José Antonio
JA
Medical Research Unit in Clinical Epidemiology, Medical Unit of High Specialty, Mexican Institute of Social Security, Guadalajara, Mexico. durun@megared.net.mx
Espaillat-Pavonessa
Manuel
M
Cárdenas-Camarena
Lázaro
L
Martínez-Abundis
Esperanza
E
González-Ortiz
Manuel
M
D050153:Abdominal Fat / Q000601:surgery*; D000328:Adult; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003687:Dehydroepiandrosterone / Q000097:blood*; D005260:Female; D006801:Humans; D015187:Lipectomy; D008055:Lipids / Q000097:blood*; D011184:Postoperative Period; D014280:Triglycerides / Q000097:blood
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008055:Lipids; D014280:Triglycerides; D003687:Dehydroepiandrosterone