title: Contact allergy in oral disease.
abstract: BACKGROUND
  The role of contact allergy in oral cavity disease processes is unknown.
  
  
  OBJECTIVE
  We sought to determine the prevalence of contact allergy to flavorings, preservatives, dental acrylates, medications, and metals in patients with oral disease.
  
  
  METHODS
  Patients were tested with an 85-item oral antigen screening series. Data were analyzed retrospectively.
  
  
  RESULTS
  We evaluated 331 patients with burning mouth syndrome, lichenoid tissue reaction, cheilitis, stomatitis, gingivitis, orofacial granulomatosis, perioral dermatitis, and recurrent aphthous stomatitis. Positive patch test results were identified in 148 of the 331 patients; 90 patients had two or more positive reactions. Allergens with the highest positive reaction rates were potassium dicyanoaurate, nickel sulfate, and gold sodium thiosulfate. Of the 341 positive patch test reactions, 221 were clinically relevant.
  
  
  CONCLUSIONS
  No follow-up data were available in this retrospective analysis.
  
  
  CONCLUSIONS
  The positive and relevant allergic reactions to metals, fragrances, and preservatives indicated that contact allergy may affect oral disease.
authors.affiliation: Department of Dermatology, Mayo Clinic, Rochester, MN 55905, USA.
authors.forename: Rochelle R
authors.initials: RR
authors.lastname: Torgerson
authors.forename: Mark D P
authors.initials: MD
authors.lastname: Davis
authors.forename: Alison J
authors.initials: AJ
authors.lastname: Bruce
authors.forename: Sara A
authors.initials: SA
authors.lastname: Farmer
authors.forename: Roy S
authors.initials: RS
authors.lastname: Rogers
mesh_terms: D000179:Acrylates / Q000009:adverse effects; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D003764:Dental Materials / Q000009:adverse effects; D017449:Dermatitis, Allergic Contact / Q000453:epidemiology* / Q000209:etiology*; D004342:Drug Hypersensitivity / Q000150:complications; D005260:Female; D005421:Flavoring Agents / Q000009:adverse effects; D006801:Humans; D008297:Male; D008670:Metals / Q000009:adverse effects; D008875:Middle Aged; D009059:Mouth Diseases / Q000139:chemically induced / Q000453:epidemiology* / Q000209:etiology*; D011310:Preservatives, Pharmaceutical / Q000009:adverse effects; D015995:Prevalence
chemical_list: D000179:Acrylates; D003764:Dental Materials; D005421:Flavoring Agents; D008670:Metals; D011310:Preservatives, Pharmaceutical