title: [Comparison of transdermal permeation in vitro of lidocaine tincture and microemulsion].
abstract: OBJECTIVE
  To compare lidocaine tincture and microemulsion for their transdermal permeation.
  
  
  METHODS
  The experimental model for percutaneous administration of lidocaine preparations in vitro was prepared using modified Franz diffusion cell.
  
  
  RESULTS
  The accumulated infiltration amount of lidocaine microemulsion in unit area was higher than that in its cream or tincture preparations.
  
  
  CONCLUSIONS
  The transdermal permeation of lidocaine microemulsion in vitro can be more efficient than that of the tincture preparation, and the permeation is linearly dependent on the dose administered within a certain range.
authors.affiliation: Institute of Pharmaceutical Sciences, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. huangl@ fimmu.com
authors.forename: Liang
authors.initials: L
authors.lastname: Huang
authors.forename: Zhi-liang
authors.initials: ZL
authors.lastname: Chen
authors.forename: Guo-feng
authors.initials: GF
authors.lastname: Li
authors.forename: Xiao-liang
authors.initials: XL
authors.lastname: Zhu
authors.forename: Chan
authors.initials: C
authors.lastname: Liu
mesh_terms: D000279:Administration, Cutaneous; D000779:Anesthetics, Local / Q000008:administration & dosage*; D004339:Drug Compounding; D016503:Drug Delivery Systems; D004655:Emulsions / Q000008:administration & dosage*; D008012:Lidocaine / Q000008:administration & dosage*; D012869:Skin Absorption
chemical_list: D000779:Anesthetics, Local; D004655:Emulsions; D008012:Lidocaine