title: Recurrent herpes simplex virus infection in a patient with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy associated with L29P and IVS9-1G>C compound heterozygous autoimmune regulator gene mutations.
abstract: Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) has characteristic clinical features with organ-specific autoimmune polyendocrine diseases and candidiasis, caused by the mutations of autoimmune regulator (AIRE) gene. Although almost all patients are complicated with mucocutaneous candidiasis, no apparent susceptibility to other infections has yet been reported. We herein report that a patient with APECED suffered from recurrent herpes simplex virus type 1 (HSV-1) infection after severe primary herpetic stomatitis, associated with sequential HSV-1 isolates of the same genomic profile, consistent with endogeneous recurrence. Thus, not only candidiasis but also HSV infection should receive more attention in patients with APECED, with treatment being administered accordingly.
authors.affiliation: Department of Medical Science and Technology, School of Medicine, Kyushu University, Fukuoka, Japan. nagafuchi@shs.kyushu-u.ac.jp
authors.forename: S
authors.initials: S
authors.lastname: Nagafuchi
authors.forename: K
authors.initials: K
authors.lastname: Umene
authors.forename: F
authors.initials: F
authors.lastname: Yamanaka
authors.forename: S
authors.initials: S
authors.lastname: Oohashi
authors.forename: M
authors.initials: M
authors.lastname: Shindo
authors.forename: H
authors.initials: H
authors.lastname: Kurisaki
authors.forename: J
authors.initials: J
authors.lastname: Kudoh
authors.forename: N
authors.initials: N
authors.lastname: Shimizu
authors.forename: T
authors.initials: T
authors.lastname: Hara
authors.forename: M
authors.initials: M
authors.lastname: Harada
mesh_terms: D000328:Adult; D001483:Base Sequence; D004252:DNA Mutational Analysis; D005260:Female; D005809:Genes, Regulator; D005814:Genes, Viral; D006561:Herpes Simplex / Q000276:immunology*; D018259:Herpesvirus 1, Human / Q000235:genetics; D006579:Heterozygote; D006801:Humans; D008969:Molecular Sequence Data; D016884:Polyendocrinopathies, Autoimmune / Q000276:immunology / Q000821:virology*; D012150:Polymorphism, Restriction Fragment Length; D012008:Recurrence