Selective tuning of the blood oxygenation level-dependent response during simple target detection dissociates human frontoparietal subregions.
Current models of working memory and focal attention converge on the idea of an adaptable global system, distributed across a network of frontal and parietal brain regions. Here, we examine how the human frontoparietal network selectively adapts to represent currently relevant information during a simple attentional task: monitoring for a target item in a series of nontargets. Across the entire frontoparietal network, there is selective response to targets, in line with a global system for coding task-relevant inputs. At the same time, there are striking dissociations in response to nontargets; whereas ventrolateral frontal cortex responds just to the target, more dorsal/anterior regions respond to all stimuli from the target category. The results show different degrees of target selectivity across different regions of the frontoparietal network.
Hampshire
Adam
A
MRC Cognition and Brain Sciences Unit, Cambridge, Cambridgeshire CB2 7EF, United Kingdom. adam.hampshire@mrc-cbu.cam.ac.uk
Duncan
John
J
Owen
Adrian M
AM
D000328:Adult; D001931:Brain Mapping / Q000379:methods; D005625:Frontal Lobe / Q000502:physiology*; D006801:Humans; D008568:Memory / Q000502:physiology; D009415:Nerve Net / Q000502:physiology; D010100:Oxygen / Q000097:blood*; D010296:Parietal Lobe / Q000502:physiology*; D010775:Photic Stimulation / Q000379:methods; D011597:Psychomotor Performance / Q000502:physiology*; D011930:Reaction Time / Q000502:physiology*
D010100:Oxygen