title: Synthesis, antifungal and antimicrobial activity of alkylphospholipids.
abstract: The antifungal, antibacterial and haemolytic activity of a series of alkylphosphocholines (e.g., miltefosine) and alkylglycerophosphocholines (e.g., edelfosine) has been investigated. These compound classes exhibit significant antifungal and moderate antibacterial activities. Several new alkylphosphocholine derivatives with amide or ester bonds in the alkyl chain have been synthesised. These compounds show much lower haemolytic activity than miltefosine. Alkylphosphocholines and alkylglycerophosphocholines show significant promise as novel orally available antifungal and antibacterial therapeutics.
authors.affiliation: School of Chemistry, The University of Sydney, NSW, Australia.
authors.forename: Daniel
authors.initials: D
authors.lastname: Obando
authors.forename: Fred
authors.initials: F
authors.lastname: Widmer
authors.forename: Lesley C
authors.initials: LC
authors.lastname: Wright
authors.forename: Tania C
authors.initials: TC
authors.lastname: Sorrell
authors.forename: Katrina A
authors.initials: KA
authors.lastname: Jolliffe
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D004912:Erythrocytes / Q000187:drug effects; D005658:Fungi / Q000187:drug effects; D015394:Molecular Structure; D010743:Phospholipids / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D010743:Phospholipids