[The treatment of hyperemesis gravidarum with chlorobutanol-caffeine rectal suppositories in Denmark: practice and evidence].
BACKGROUND
In Denmark chlorobutanol-caffeine rectal suppositories are prescribed by some obstetric departments for the treatment of hyperemesis gravidarum.


METHODS
We have investigated the extent of this use by questionnaire, and we have performed a literature review on the evidence of efficacy and safety.


RESULTS
The use of chlorobutanol-caffeine rectal suppositories was reported by 5 out of 28 obstetric departments in Denmark. The literature search revealed that there is very sparse information on chlorobutanol. No evidence was found of safety during pregnancy in humans or efficiency as antiemetic treatment in hyperemesis gravidarum.


CONCLUSIONS
There is no evidence of the efficacy or safety of chlorobutanol-caffeine suppositories for the treatment of hyperemesis gravidarum.
Brødbaek
Herdis Bohn Olesen
HB
Universitetshospital, Afdeling for Biokemi, Farmakologi og Genetik. bohn@dadlnet.dk
Damkier
Per
P
D000932:Antiemetics / Q000008:administration & dosage* / Q000009:adverse effects; D002110:Caffeine / Q000008:administration & dosage* / Q000009:adverse effects; D002724:Chlorobutanol / Q000008:administration & dosage* / Q000009:adverse effects; D004338:Drug Combinations; D004363:Drug Utilization; D019317:Evidence-Based Medicine; D005260:Female; D006801:Humans; D006939:Hyperemesis Gravidarum / Q000188:drug therapy*; D011247:Pregnancy; D012449:Safety; D013488:Suppositories; D011795:Surveys and Questionnaires
D000932:Antiemetics; D004338:Drug Combinations; D013488:Suppositories; D002110:Caffeine; D002724:Chlorobutanol