[Distribution characters and linkage disequilibrium analysis of APOM gene polymorphisms in Han population of North China].
OBJECTIVE
To investigate the distribution characters and linkage disequilibrium of apolipoprotein M gene (APOM) polymorphisms in Han population of North China.


METHODS
The single nucleotide polymorphisms (SNPs) in six exons and five introns of APOM gene of 330 normal subjects in Han population of North China were detected by PCR-restriction fragment length polymorphism and DNA sequencing analysis.


RESULTS
Three SNPs in Han Chinese were found, including rs805264 of intron 1, rs707922 and rs707921 of intron 5 of APOM gene. The frequency distribution of these SNPs was different among different races and territory. In addition, linkage disequilibrium among the SNPs of rs805264, rs707922 and rs707921 of APOM gene was found and A-T-A and G-G-C were predominant haplotypes.


CONCLUSIONS
There is apparent linkage disequilibrium among SNPs of APOM gene in Han population of North China.
Han
Xiu-jie
XJ
Department of Neurology, Xuanwu Hospital, Capital University of Medical Sciences, Beijing, 100053 PR China.
Jia
Jian-ping
JP
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001053:Apolipoproteins / Q000235:genetics*; D000075243:Apolipoproteins M; D044466:Asian People / Q000235:genetics*; D002681:China; D005006:Ethnicity / Q000235:genetics*; D005260:Female; D006801:Humans; D007438:Introns / Q000235:genetics; D015810:Linkage Disequilibrium; D054834:Lipocalins; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide
C400523:APOM protein, human; D001053:Apolipoproteins; D000075243:Apolipoproteins M; D054834:Lipocalins