title: folA, a new member of the TyrR regulon in Escherichia coli K-12.
abstract: The folA gene was identified as a new member of the TyrR regulon by genomic SELEX. Binding of TyrR to two sites in folA activated its transcription. Mutations in the N-terminal or central domain of TyrR, the alpha subunit of RNA polymerase, or integration host factor all abolished activation of the folA promoter.
authors.affiliation: Department of Microbiology and Immunology, The University of Melbourne, Victoria 3010, Australia.
authors.forename: Ji
authors.initials: J
authors.lastname: Yang
authors.forename: Yoshito
authors.initials: Y
authors.lastname: Ogawa
authors.forename: Helen
authors.initials: H
authors.lastname: Camakaris
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Shimada
authors.forename: Akira
authors.initials: A
authors.lastname: Ishihama
authors.forename: A J
authors.initials: AJ
authors.lastname: Pittard
mesh_terms: D004926:Escherichia coli / Q000235:genetics*; D029968:Escherichia coli Proteins / Q000737:chemistry* / Q000302:isolation & purification; D015964:Gene Expression Regulation, Bacterial; D018085:Regulon / Q000235:genetics*; D012097:Repressor Proteins / Q000737:chemistry* / Q000235:genetics / Q000502:physiology; D013762:Tetrahydrofolate Dehydrogenase / Q000378:metabolism
chemical_list: D029968:Escherichia coli Proteins; D012097:Repressor Proteins; C069256:TyrR protein, E coli; D013762:Tetrahydrofolate Dehydrogenase