title: Dynamics of cytogenetic aberrations in Philadelphia chromosome positive and negative hematopoiesis during dasatinib therapy of chronic myeloid leukemia patients after imatinib failure.
abstract: Clonal cytogenetic aberrations of the Philadelphia chromosome (Ph) positive hematopoiesis have been associated with the natural evolution of chronic myeloid leukemia (CML) to advanced disease. Clonal aberrations of Ph negative metaphases have been described after treatment with interferon or imatinib. This study evaluates the effect of dasatinib on Ph positive clones with additional cytogenetic aberrations and the frequency of novel aberrations in Ph positive and negative metaphases. Seventy-one patients treated with dasatinib after imatinib failure for a median of nine months were evaluated. Novel aberrations within Ph positive and negative clones appeared in six and three patients, respectively.
authors.affiliation: III. Medizinische Universitätsklinik, Medizinische Fakultät Mannheim der Ruprecht-Karls-Universität Heidelberg, Mannheim, Germany. alice.fabarius@med3.ma.uni-heidelberg.de
authors.forename: Alice
authors.initials: A
authors.lastname: Fabarius
authors.forename: Claudia
authors.initials: C
authors.lastname: Haferlach
authors.forename: Martin C
authors.initials: MC
authors.lastname: Müller
authors.forename: Philipp
authors.initials: P
authors.lastname: Erben
authors.forename: Tanja
authors.initials: T
authors.lastname: Lahaye
authors.forename: Michelle
authors.initials: M
authors.lastname: Giehl
authors.forename: Oliver
authors.initials: O
authors.lastname: Frank
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Seifarth
authors.forename: Rüdiger
authors.initials: R
authors.lastname: Hehlmann
authors.forename: Andreas
authors.initials: A
authors.lastname: Hochhaus
mesh_terms: D000328:Adult; D000368:Aged; D001549:Benzamides; D002869:Chromosome Aberrations; D002999:Clone Cells; D000069439:Dasatinib; D006410:Hematopoiesis / Q000235:genetics*; D006801:Humans; D000068877:Imatinib Mesylate; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy* / Q000235:genetics* / Q000473:pathology; D008875:Middle Aged; D010677:Philadelphia Chromosome; D010879:Piperazines / Q000627:therapeutic use; D011743:Pyrimidines / Q000494:pharmacology / Q000627:therapeutic use*; D016879:Salvage Therapy; D013844:Thiazoles / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D001549:Benzamides; D010879:Piperazines; D011743:Pyrimidines; D013844:Thiazoles; D000068877:Imatinib Mesylate; D000069439:Dasatinib