Are xenogeneic anti-tissue transglutaminase antibodies the holy grail for celiac patients?
Celiac disease is an immune mediated disorder, the only one with a well-established origin, resulting from a permanent gluten intolerance. Although a gluten-free diet is currently the "safe" and appropriate therapy for celiac disease, this is not always an easy and simple option as "harmful" gluten may contaminate food during the processing and preparation phases. There are also further social pressures, which might be more pressing for young celiac patients, in following a strict gluten-free diet. Therefore, a new therapeutic approaches are sought which would permit celiacs to "peacefully" coexist with gluten. Presently, the most promising looks search for genetically modified wheat lacking toxic gluten peptides and the use of oral endopeptidases in attempt to curb gluten toxicity. Recently discovered role of anti-tissue transglutaminase antibodies in celiac pathogenesis has brought a prospect for a new hypothetical therapeutic approach, an oral immunization of celiacs with xenogeneic anti-tissue transglutaminase antibodies.
Ivanovski
Petar Ilija
PI
University Children's Hospital, 10 Tirshova Str., Belgrade, Serbia. ivanovsk@eunet.yu <ivanovsk@eunet.yu>
Ivanovski
Ivan P
IP
Sedlarevic
Rade
R
D000284:Administration, Oral; D000906:Antibodies / Q000737:chemistry; D000910:Antibodies, Heterophile / Q000737:chemistry*; D001323:Autoantibodies / Q000737:chemistry; D002446:Celiac Disease / Q000178:diet therapy / Q000276:immunology* / Q000628:therapy*; D004032:Diet; D010450:Endopeptidases / Q000494:pharmacology; D005983:Glutens / Q000737:chemistry; D006801:Humans; D007413:Intestinal Mucosa / Q000276:immunology; D008962:Models, Theoretical; D011503:Transglutaminases / Q000737:chemistry* / Q000276:immunology
D000906:Antibodies; D000910:Antibodies, Heterophile; D001323:Autoantibodies; D005983:Glutens; D011503:Transglutaminases; D010450:Endopeptidases