A guideline-driven assessment of need for cardiovascular disease risk intervention in persons with chronic paraplegia.
OBJECTIVE
To examine percentages of persons with chronic paraplegia who qualify for lipid-lowering therapeutic lifestyle intervention (TLI) as assessed by authoritative guidelines.


METHODS
Cross-sectional.


METHODS
Academic medical center.


METHODS
Forty-one subjects (mean age +/- standard deviation, 34+/-11 y) with motor-complete paraplegia (American Spinal Injury Association grade A or B) at T6-L1 levels for greater than 2 years.


METHODS
Not applicable.


METHODS
Percentages of subjects qualifying for TLI were independently assessed and then compared using National Cholesterol Education Project Adult Treatment Panel (ATP) II (1994) and ATP III (2002) Guidelines.


RESULTS
A total of 34.1% of subjects qualified for intervention based on the ATP II Guidelines and 63.4% based on ATP III (chi1(2) test=4.53; 2-tailed, P=.003). Seventy-six percent (31/41) of study participants had high-density lipoprotein cholesterol levels below the high-risk criterion of 40 mg/dL established by ATP III. Almost one third of subjects had hypertension, and 34.1% satisfied criteria for diagnosis of the metabolic syndrome.


CONCLUSIONS
A high percentage of young, apparently healthy people with chronic paraplegia are at risk for cardiovascular disease and qualify for lipid-lowering TLI. Updated guidelines of the ATP III have increased the urgency for early risk assessment and intervention.
Nash
Mark S
MS
Department of Neurological Surgery, Miller School of Medicine, University of Miami, Miami, FL 33136, USA. mnash@med.miami.edu
Mendez
Armando J
AJ
D000046:Academic Medical Centers; D000328:Adult; D002318:Cardiovascular Diseases / Q000150:complications / Q000517:prevention & control*; D002908:Chronic Disease; D003430:Cross-Sectional Studies; D050171:Dyslipidemias / Q000150:complications / Q000188:drug therapy*; D005260:Female; D006801:Humans; D000960:Hypolipidemic Agents / Q000627:therapeutic use*; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D010264:Paraplegia / Q000150:complications; D017410:Practice Guidelines as Topic; D018570:Risk Assessment; D013119:Spinal Cord Injuries / Q000150:complications*; D015599:Trauma Severity Indices
D000960:Hypolipidemic Agents; D008055:Lipids