title: [Discoidin domain receptors (DDRs) expression in pathological scar fibroblast formation].
abstract: OBJECTIVE
  To explore the role of discoidin domain receptors (DDRs) in the formation of the keloid.
  
  
  METHODS
  The real-time quantitative PCR was used to compare the DDRs expression in the keloids and normal fibroblasts.
  
  
  RESULTS
  The level of DDR1 expression was significantly higher in keloid than in normal fibroblast (20.98 vs 4.2, P <0.01; 7.9 vs 4.23, P <0.05). The level of DDR1 expression in keloid was also higher significantly than that in hypertropic scar (20.98 vs 7.9, P < 0.01). However, the level of DDR2 expression was somewhat higher in keloid than in normal fibroblasts, the difference seemed not to be significantly in probability (358, 332 vs 278, P > 0.05).
  
  
  CONCLUSIONS
  DDRs may exert effect on keloid cell behaviours.
authors.affiliation: Department of Plastic Surgery, Changhai Hospital, Shanghai 200433, China.
authors.forename: Yu-Zhi
authors.initials: YZ
authors.lastname: Jiang
authors.forename: Xin
authors.initials: X
authors.lastname: Xing
authors.forename: Jun-Hui
authors.initials: JH
authors.lastname: Wen
authors.forename: Chun-Yu
authors.initials: CY
authors.lastname: Xue
authors.forename: Jing-De
authors.initials: JD
authors.lastname: Zhang
authors.forename: Ming-li
authors.initials: ML
authors.lastname: Zhang
mesh_terms: D049109:Cell Proliferation; D002478:Cells, Cultured; D002921:Cicatrix / Q000378:metabolism* / Q000473:pathology*; D000070818:Discoidin Domain Receptors; D005260:Female; D005347:Fibroblasts / Q000378:metabolism*; D006801:Humans; D008297:Male; D020794:Receptor Protein-Tyrosine Kinases / Q000378:metabolism*; D011975:Receptors, Mitogen / Q000378:metabolism*
chemical_list: D011975:Receptors, Mitogen; D000070818:Discoidin Domain Receptors; D020794:Receptor Protein-Tyrosine Kinases