title: Gastric mucin is expressed in a subset of endocervical tunnel clusters: type A tunnel clusters of gastric phenotype.
abstract: OBJECTIVE
  Gastric mucin expression has been demonstrated in a group of endocervical glandular lesions. The aim of this study was to gain further insight into endocervical lesions with a gastric phenotype.
  
  
  RESULTS
  Various types of tunnel clusters (TC) were examined for gastric mucin by alcian blue/periodic acid-Schiff staining and immunohistochemistry for HIK1083. Five of 34 cases of TC expressed gastric mucin defined by PAS dominant neutral mucin and immunopositivity for pyloric gland mucin. Histologically, TC expressing gastric mucin showed lobular arrangements of small to medium-sized glands composed of mucin-rich columnar cells and were classified as Flumann's type A TC. Neither type B TC nor normal endocervical glands expressed PAS dominant neutral mucin and none of them was immunopositive for pyloric gland mucin. Five patients with type A TC of gastric phenotype ranged in age from 33 to 79 years (mean 58 years) and were multiparous. Type A TC of gastric phenotype, ranging from 2 to 4 mm in maximum diameter, were incidental findings in hysterectomy specimens.
  
  
  CONCLUSIONS
  Type A TC of gastric phenotype could be related to lobular endocervical glandular hyperplasia of gastric phenotype. The pathogenesis of gastric metaplasia in TC remains unclear.
authors.affiliation: Department of Pathology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan. ktetsuo@yamanashi.ac.jp
authors.forename: T
authors.initials: T
authors.lastname: Kondo
authors.forename: A
authors.initials: A
authors.lastname: Hashi
authors.forename: S-I
authors.initials: SI
authors.lastname: Murata
authors.forename: S E
authors.initials: SE
authors.lastname: Fischer
authors.forename: M
authors.initials: M
authors.lastname: Nara
authors.forename: T
authors.initials: T
authors.lastname: Nakazawa
authors.forename: T
authors.initials: T
authors.lastname: Yuminamochi
authors.forename: K
authors.initials: K
authors.lastname: Hoshi
authors.forename: R
authors.initials: R
authors.lastname: Katoh
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000378:metabolism; D002584:Cervix Uteri / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D003560:Cysts / Q000378:metabolism / Q000473:pathology; D005260:Female; D005752:Gastric Mucins / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D008679:Metaplasia / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D008875:Middle Aged; D010503:Periodic Acid-Schiff Reaction; D010641:Phenotype; D002577:Uterine Cervical Diseases / Q000378:metabolism* / Q000473:pathology
chemical_list: D015415:Biomarkers; D005752:Gastric Mucins