Coordination of cell proliferation and differentiation: finding a GEM in the root?
How cells acquire specific fates in conjunction with cell division is a major developmental question. In a recent issue of Nature, Caro and colleagues describe the Arabidopsis protein GEM, which interacts both with DNA-replication and transcriptional regulators (Caro et al., 2007). The results are surprisingly reminiscent of the dual functions reported for Geminin in animals.
Wildwater
Marjolein
M
Division of Developmental Biology, Faculty of Science, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands.
The
Inge
I
van den Heuvel
Sander
S
D000818:Animals; D029681:Arabidopsis Proteins / Q000378:metabolism*; D002453:Cell Cycle / Q000502:physiology*; D018797:Cell Cycle Proteins / Q000378:metabolism / Q000502:physiology; D002454:Cell Differentiation; D049109:Cell Proliferation; D004261:DNA Replication / Q000502:physiology; D047108:Embryonic Development / Q000502:physiology; D064248:Geminin; D018507:Gene Expression Regulation, Developmental / Q000502:physiology; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D050436:Regulatory Elements, Transcriptional
D029681:Arabidopsis Proteins; D018797:Cell Cycle Proteins; C520031:GEM protein, Arabidopsis; C577995:GMNN protein, human; D064248:Geminin; D047908:Intracellular Signaling Peptides and Proteins