title: Chemopreventive effect of aerosolized polyphenon E on lung tumorigenesis in A/J mice.
abstract: Effective chemoprevention of lung cancer in high-risk patients through the administration of pharmacologic or nutritional agents is urgently needed. Aerosol inhalation can deliver chemopreventive agents directly to the respiratory tract to inhibit the tumorigenic process. In this study, polyphenon E (PolyE) and (-)-epigallocatechin-3-gallate (EGCG) were administered by aerosol delivery to A/J mice beginning 2 weeks after carcinogen treatment and continuing daily by inhalation throughout the remainder of the study (20 weeks). PolyE decreased tumor load by approximately 59%. However, EGCG, both at the same dose and at a higher dose, failed to inhibit lung carcinogenesis. These results indicate that aerosol delivery of PolyE, but not EGCG, may be a useful chemopreventive protocol in subjects at high risk for lung cancer.
authors.affiliation: Department of Surgery, The Alvin J. Siteman Cancer Center, Washington University School of Medicine, Campus Box 8109, 660 South Euclid Avenue, St. Louis, MO 63110, USA.
authors.forename: Ying
authors.initials: Y
authors.lastname: Yan
authors.forename: Julie
authors.initials: J
authors.lastname: Cook
authors.forename: Jay
authors.initials: J
authors.lastname: McQuillan
authors.forename: Guifang
authors.initials: G
authors.lastname: Zhang
authors.forename: Cory J
authors.initials: CJ
authors.lastname: Hitzman
authors.forename: Yian
authors.initials: Y
authors.lastname: Wang
authors.forename: Timothy S
authors.initials: TS
authors.lastname: Wiedmann
authors.forename: Ming
authors.initials: M
authors.lastname: You
mesh_terms: D000336:Aerosols; D000818:Animals; D016588:Anticarcinogenic Agents / Q000008:administration & dosage*; D001564:Benzo(a)pyrene; D002392:Catechin / Q000008:administration & dosage / Q000031:analogs & derivatives*; D005260:Female; D008175:Lung Neoplasms / Q000473:pathology / Q000517:prevention & control*; D051379:Mice
chemical_list: D000336:Aerosols; D016588:Anticarcinogenic Agents; D001564:Benzo(a)pyrene; D002392:Catechin; C045651:epigallocatechin gallate; C472086:polyphenon E