title: Reduction of dioxins and polychlorinated biphenyls (PCBs) in human body.
abstract: The accumulation of persistent lipophilic organic pollutants like dioxins and PCBs in human body is of great concern since many of these compounds may elicit adverse health effects on humans. To reduce dioxins and PCBs with long half-lives that are absorbed into the human body, we need to work actively to minimize accumulation of dioxins and PCBs taken. Lot of manner has been tested such as foods containing dietary fibers and chlorophyll, lipids (squalane etc) and anion exchange resins. Cholestyramine, a cholesterol lowering agent, was no efficacy in humans. Authors have conducted a pilot study to demonstrate the effect lowering dioxin in human bodies using colestimide. Nine patients on cdestimide for 6 months, showed mean 20% decrease respectively in both dioxin and PCB levels, and the maximum percentage decrease was approximately 40%. From a standpoint to avoid the influence on high-risk group and high-risk life stage other than next generation, the world-wide cooperation for reducing environmental chemicals is greatly appealed.
authors.affiliation: Department of Bioenvironmental Medicine, Graduate School of Medicine, Chiba University, Chuo-ku, Chiba 260-8670, Japan.
authors.forename: Yoji
authors.initials: Y
authors.lastname: Mochida
authors.forename: Hideki
authors.initials: H
authors.lastname: Fukata
authors.forename: Yoshiharu
authors.initials: Y
authors.lastname: Matsuno
authors.forename: Chisato
authors.initials: C
authors.lastname: Mori
mesh_terms: D002606:Charcoal / Q000627:therapeutic use; D002734:Chlorophyll / Q000378:metabolism; D004043:Dietary Fiber / Q000378:metabolism; D004147:Dioxins / Q000493:pharmacokinetics*; D006801:Humans; D007475:Ion Exchange Resins / Q000627:therapeutic use; D050356:Lipid Metabolism; D011078:Polychlorinated Biphenyls / Q000493:pharmacokinetics*
chemical_list: D004043:Dietary Fiber; D004147:Dioxins; D007475:Ion Exchange Resins; D002734:Chlorophyll; D002606:Charcoal; D011078:Polychlorinated Biphenyls