Modulation of neural activities by Na, K-ATPase alpha 2 subunit through functional coupling with transporters.
Na,K-ATPase is the active transporter that maintains Na+ and K+ gradients across the cell membrane. The enzyme is composed of Alpha and Beta subunits and there are four Alpha and three Beta subunit isoforms. The enzyme is responsible for various physiological processes including housekeeping function of animal cells, and specific function has been allocated to each isoform during evolution. We found that the Na,K-ATPase Alpha2 subunit functions in concert with various transporters during ontogeny by analyses of phenotypes of mice with defective Alpha2 subunit. The homozygous mice die soon after birth without breathing and the heterozygous mice show late-onset obesity. We summarize here the specific functions of the Na,K-ATPase Alpha2 subunit and physiological roles in vivo.
Kawakami
K
K
Division of Biology, Center for Molecular Medicine, Jichi Medical University, Yakushiji, Shimotsuke-shi, Japan. kkawakam@jichi.ac.jp
Ikeda
K
K
D000818:Animals; D001007:Anxiety / Q000235:genetics / Q000378:metabolism; D001522:Behavior, Animal / Q000502:physiology; D001921:Brain / Q000378:metabolism / Q000502:physiology*; D002118:Calcium / Q000378:metabolism; D006720:Homozygote; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D020325:Migraine with Aura / Q000235:genetics / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D009765:Obesity / Q000235:genetics / Q000378:metabolism; D021122:Protein Subunits / Q000235:genetics / Q000502:physiology; D000254:Sodium-Potassium-Exchanging ATPase / Q000235:genetics / Q000502:physiology*; D027981:Symporters / Q000378:metabolism*; D000096922:K Cl- Cotransporters
D002118:Calcium; D021122:Protein Subunits; D000254:Sodium-Potassium-Exchanging ATPase; D027981:Symporters; D000096922:K Cl- Cotransporters