title: Alpha-synuclein accumulates in the brain of scrapie-affected sheep and goats.
abstract: Immunohistochemical examination demonstrated widespread granular deposits of alpha-synuclein (alphaSN) in the brains of sheep and goats with natural scrapie, especially in the cornu ammonis and subiculum of the hippocampus; this contrasted with the diffuse and non-granular immunolabelling seen in healthy controls. There was non-regular "co-localization" of PrP(Sc) and alphaSN. The findings resembled those reported in Creutzfeldt-Jakob disease and in experimental prion disease in hamsters and mice. The results suggest that perturbation of alphaSN metabolism plays a role in human and animal prion diseases.
authors.affiliation: Ecole Nationale Vétérinaire d'Alfort (Laboratoire de Pathologie Médicale du Bétail and Service de Physiologie et Thérapeutique), 7 Avenue du Général de Gaulle, 94 704 Maisons-Alfort, Cedex. Electronic address: kadjou@vet-alfort.fr.
authors.forename: K T
authors.initials: KT
authors.lastname: Adjou
authors.affiliation: Ecole Nationale Vétérinaire d'Alfort (Laboratoire de Pathologie Médicale du Bétail and Service de Physiologie et Thérapeutique), 7 Avenue du Général de Gaulle, 94 704 Maisons-Alfort, Cedex.
authors.forename: S
authors.initials: S
authors.lastname: Allix
authors.affiliation: Ecole Nationale Vétérinaire d'Alfort (Laboratoire de Pathologie Médicale du Bétail and Service de Physiologie et Thérapeutique), 7 Avenue du Général de Gaulle, 94 704 Maisons-Alfort, Cedex.
authors.forename: M O
authors.initials: MO
authors.lastname: Ouidja
authors.affiliation: Ecole Nationale Vétérinaire d'Alfort (Laboratoire de Pathologie Médicale du Bétail and Service de Physiologie et Thérapeutique), 7 Avenue du Général de Gaulle, 94 704 Maisons-Alfort, Cedex.
authors.forename: S
authors.initials: S
authors.lastname: Backer
authors.affiliation: Laboratoire Départemental Vétérinaire, Avenue du Professeur J de Léobardy, 87 000 Limoges.
authors.forename: C
authors.initials: C
authors.lastname: Couquet
authors.affiliation: Laboratoire Départemental Vétérinaire, Avenue du Professeur J de Léobardy, 87 000 Limoges.
authors.forename: M-J
authors.initials: MJ
authors.lastname: Cornuejols
authors.affiliation: GID/TIP, CEA, DSV/DRM, 18 rue du Panorama, 92 265 Fontenay-aux-Roses, Cedex.
authors.forename: J-P
authors.initials: JP
authors.lastname: Deslys
authors.affiliation: Ecole Nationale Vétérinaire d'Alfort (Laboratoire de Pathologie Médicale du Bétail and Service de Physiologie et Thérapeutique), 7 Avenue du Général de Gaulle, 94 704 Maisons-Alfort, Cedex.
authors.forename: H
authors.initials: H
authors.lastname: Brugère
authors.affiliation: Ecole Nationale Vétérinaire d'Alfort (Laboratoire de Pathologie Médicale du Bétail and Service de Physiologie et Thérapeutique), 7 Avenue du Général de Gaulle, 94 704 Maisons-Alfort, Cedex.
authors.forename: J
authors.initials: J
authors.lastname: Brugère-Picoux
authors.affiliation: EPHE and INSERM U616, Hôpital la Salpêtrière, 47 Boulevard de l'Hôpital, 75 013 Paris, France.
authors.forename: K H
authors.initials: KH
authors.lastname: El-Hachimi
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism* / Q000473:pathology; D005260:Female; D005786:Gene Expression Regulation; D015511:Goat Diseases / Q000378:metabolism* / Q000473:pathology; D006041:Goats; D011328:Prions / Q000235:genetics / Q000378:metabolism; D012608:Scrapie / Q000378:metabolism* / Q000473:pathology; D012756:Sheep; D051844:alpha-Synuclein / Q000235:genetics / Q000378:metabolism*
chemical_list: D011328:Prions; D051844:alpha-Synuclein