title: Optical tomography with ultrasound localization for breast cancer diagnosis and treatment monitoring.
abstract: Optical tomography with ultrasound (US) localization uses coregistered ultrasound images to guide optical imaging reconstruction. To simultaneously acquire US images and optical measurements, the authors used a hand-held probe consisting of a commercial US transducer and near-infrared optical imaging sensors of multiple wavelengths. A novel image scheme was used to map the ultrasound-visible lesions for optical imaging reconstruction. As a result, the problem of intense light scattering caused by breast tissue was overcome and reliable tumor hemoglobin concentration and blood oxygen saturation distributions from a group of patients were obtained. These functional parameters are valuable for aiding US diagnosis and for assessing chemotherapy response.
authors.affiliation: Bioengineering Program, Electrical and Computer Engineering Department, 371 Fairfield Way, University of Connecticut, Storrs, CT 03269, USA.
authors.forename: Quing
authors.initials: Q
authors.lastname: Zhu
authors.forename: Susan
authors.initials: S
authors.lastname: Tannenbaum
authors.forename: Scott H
authors.initials: SH
authors.lastname: Kurtzman
mesh_terms: D001943:Breast Neoplasms / Q000175:diagnosis* / Q000628:therapy; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D041622:Tomography, Optical / Q000295:instrumentation / Q000379:methods*; D016217:Ultrasonography, Mammary / Q000295:instrumentation / Q000379:methods*