title: Metabolic epidermal necrosis in a dog associated with pancreatic adenocarcinoma, hyperglucagonaemia, hyperinsulinaemia and hypoaminoacidaemia.
abstract: A case of metabolic epidermal necrosis associated with a pancreatic carcinoma is described. Normoglycaemia, reduced serum fructosamine, and hypoaminoacidaemia were identified. Hyperinsulinaemia and hyperglucagonaemia were documented. Immunohistochemistry documented strong tumour expression of both insulin and glucagon supporting combined paraneoplastic production of both hormones by the tumour. Enteral protein and fatty acid supplementation and parenteral amino acid supplementation proved ineffective. Metastasis to regional lymph nodes was identified and the patient was euthanased.
authors.affiliation: Cave Referrals, Sandwell, 7 Hectors Stones, Woolavington, Somerset TA7 8EG, UK.
authors.forename: T A
authors.initials: TA
authors.lastname: Cave
authors.forename: H
authors.initials: H
authors.lastname: Evans
authors.forename: J
authors.initials: J
authors.lastname: Hargreaves
authors.forename: A S
authors.initials: AS
authors.lastname: Blunden
mesh_terms: D000230:Adenocarcinoma / Q000150:complications / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D000596:Amino Acids / Q000097:blood; D000818:Animals; D004283:Dog Diseases / Q000209:etiology / Q000378:metabolism / Q000473:pathology*; D004285:Dogs; D017809:Fatal Outcome; D005260:Female; D005934:Glucagon / Q000097:blood; D006946:Hyperinsulinism / Q000150:complications / Q000378:metabolism / Q000473:pathology / Q000662:veterinary; D010190:Pancreatic Neoplasms / Q000150:complications / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*
chemical_list: D000596:Amino Acids; D005934:Glucagon