title: Antimicrobial resistance among invasive isolates of Streptococcus pneumoniae collected across Canada.
abstract: Between 2002 and 2003, 736 nonduplicate Streptococcus pneumoniae isolated from blood cultures were collected from 7 of 10 Canadian provinces (10 tertiary care centers). Microdilution broth susceptibility testing was performed using the method prescribed by the Clinical Laboratory Standards Institute. Of the isolates, 16.85% were nonsusceptible to penicillin and 5.4% were highly resistant. Of the S.pneumoniae, 14.1% had reduced susceptibility to erythromycin and 47% had been accounted for by the M phenotype. No isolates were recovered that were resistant to telithromycin. Only 6 isolates were resistant to levofloxacin and gatifloxacin. Of these, 5 strains had intermediate susceptibility to moxifloxacin and 1 was considered susceptible. The rates observed in this study are in keeping with previous surveillance studies among noninvasive isolates.
authors.affiliation: Queen Elizabeth II Health Sciences Centre, Dalhousie University, Halifax, Nova Scotia, Canada. ross.davidson@cdha.nshealth.ca
authors.forename: Ross J
authors.initials: RJ
authors.lastname: Davidson
authors.forename: Roberto
authors.initials: R
authors.lastname: Melano
authors.forename: Kevin R
authors.initials: KR
authors.lastname: Forward
mesh_terms: D016470:Bacteremia / Q000453:epidemiology / Q000382:microbiology; D002170:Canada / Q000453:epidemiology; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics*; D006801:Humans; D008826:Microbial Sensitivity Tests; D018571:Sentinel Surveillance; D013290:Streptococcal Infections / Q000453:epidemiology*; D013296:Streptococcus pneumoniae / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification / Q000472:pathogenicity