Dual bioactivity of resveratrol fatty alcohols: differentiation of neural stem cells and modulation of neuroinflammation.
The synthesis of resveratrol fatty alcohols (RFAs), a new class of small molecules presenting strong potential for the treatment of neurological diseases, is described. RFAs, hybrid compounds combining the resveratrol nucleus and omega-alkanol side chains, are able to modulate neuroinflammation and to induce differentiation of neural stem cells into mature neurons. Acting on neuroprotection and neuroregeneration, RFAs represent an innovative approach for the treatment or cure of neuropathies.
Hauss
Frédérique
F
Laboratoire de Chimie Organique des Substances Naturelles, UMR 7177 CNRS, Université Louis Pasteur, 67084 Strasbourg Cedex, France.
Liu
Jiawei
J
Michelucci
Alessandro
A
Coowar
Djalil
D
Morga
Eleonora
E
Heuschling
Paul
P
Luu
Bang
B
D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects*; D002460:Cell Line; D005233:Fatty Alcohols / Q000494:pharmacology*; D007249:Inflammation / Q000473:pathology*; D051379:Mice; D009420:Nervous System / Q000166:cytology / Q000187:drug effects*; D000077185:Resveratrol; D013234:Stem Cells / Q000187:drug effects*; D013267:Stilbenes / Q000494:pharmacology*
D005233:Fatty Alcohols; D013267:Stilbenes; D000077185:Resveratrol