Development of a catalytic aromatic decarboxylation reaction.
A palladium-catalyzed aromatic decarboxylation reaction has been developed. With electron-rich aromatic acids, the reaction proceeds efficiently under fairly mild conditions in good yields. The method was useful with complex functionalized substrates containing hindered carboxylic acids.
Dickstein
Joshua S
JS
Department of Chemistry, Roy and Diana Vagelos Laboratories, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Mulrooney
Carol A
CA
O'Brien
Erin M
EM
Morgan
Barbara J
BJ
Kozlowski
Marisa C
MC
D002384:Catalysis; D003653:Decarboxylation; D006841:Hydrocarbons, Aromatic / Q000737:chemistry*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry
D006841:Hydrocarbons, Aromatic; D010165:Palladium