[CT perfusion study of acute local cerebral infarction in rhesus monkeys].
OBJECTIVE
To explore the value of CT perfusion in early diagnosis and management of superacute local cerebral infarction in rhesus monkeys.


METHODS
Acute local cerebral infarction was induced in the rhesus monkeys during digital subtraction angiography (DSA) by introduction of pale thrombus prepared from autologous blood into the M1 branch of the middle cerebral artery (MCA). Plain CT scan and CT perfusion scanning were performed at different time points before and after DSA operation, and the results were analyzed in conjunction with the pathologic changes.


RESULTS
Ischemic lesions were displayed on CT perfusion images, which showed local hypoperfusion, reduced cerebral blood flow and volume, and mean transit time delay in the compromised area. Local hypointense infarct area was identified in plain CT scan 24 h after the DSA operation, and the results were in good agreement with pathological examination during autopsy.


CONCLUSIONS
CT perfusion imaging of the brain can accurately capture the cerebral perfusion deficits in acute ischemic stroke before morphologic changes take place, and therefore provides good means for thrombolytic treatment evaluation of stroke.
He
Zhuo-kai
ZK
Imaging Center of Radiology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. jocky0606@163.com
Xu
Yi-kai
YK
Qiu
Wei-jia
WJ
Deng
Yan-xian
YX
Zhou
Zhi-peng
ZP
Huang
Zhi-hong
ZH
Feng
Fei-ling
FL
Wei
Ying
Y
Gan
Rui-jing
RJ
Yu
Jun-xiong
JX
D000208:Acute Disease; D000818:Animals; D001921:Brain / Q000000981:diagnostic imaging*; D002545:Brain Ischemia / Q000175:diagnosis; D002544:Cerebral Infarction / Q000175:diagnosis*; D003287:Contrast Media / Q000008:administration & dosage; D042241:Early Diagnosis; D008253:Macaca mulatta; D010477:Perfusion; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000379:methods*
D003287:Contrast Media