Hepatocellular carcinoma with peritoneal dissemination which was regressed during vitamin K2 and vitamin E administration.
A 65-year-old man with positive anti-hepatitis C antibody and chronic renal failure was diagnosed as having a ruptured hepatocellular carcinoma (HCC) based on computed tomography (CT). The patient underwent transcatheter arterial embolization (TAE) for the HCC. After one more session of TAE, the patient underwent surgery. But HCC seeding peritoneally was pointed out. Vitamin K2 and vitamin E were administered as a conservative treatment. Six months after starting vitamins K2 and E, the primary tumor did not increase in size and intraperitoneal dissemination disappeared on CT with a significant decrease of alpha-fetoprotein. Even though this is only one case, combination therapy of vitamin K2 and E may induce growth suppression of HCC.
Otsuka
Toshiyuki
T
Department of Internal Medicine, Tone Chuo Hospital, Numata. tcht-otsuka@tonehoken.or.jp
Hagiwara
Satoshi
S
Tojima
Hiroki
H
Yoshida
Hiroaki
H
Takahashi
Tetsushi
T
Nagasaka
Kazumi
K
Tomioka
Shinichi
S
Ando
Tetsu
T
Takeuchi
Kunio
K
Kori
Takayuki
T
Ohno
Yoshihiro
Y
Kakizaki
Satoru
S
Takagi
Hitoshi
H
Mori
Masatomo
M
D000368:Aged; D017209:Apoptosis / Q000187:drug effects; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy* / Q000556:secondary*; D003131:Combined Modality Therapy; D004359:Drug Therapy, Combination; D004621:Embolization, Therapeutic; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology*; D008297:Male; D009366:Neoplasm Seeding; D010534:Peritoneal Neoplasms / Q000188:drug therapy* / Q000556:secondary*; D012422:Rupture, Spontaneous; D014810:Vitamin E / Q000627:therapeutic use*; D024482:Vitamin K 2 / Q000627:therapeutic use*; D014815:Vitamins / Q000627:therapeutic use
D014815:Vitamins; D024482:Vitamin K 2; D014810:Vitamin E