[Gastrointestinal cancer in four medical centers in Mexico City. A 25-year study].
BACKGROUND
Digestive cancer is an important mortality cause in Mexico. In the past decades a change in the frequency of digestive malignancies has been observed.


OBJECTIVE
To evaluate the frequency of digestive malignancies in four hospitals in México City during a 25 years period.


METHODS
All digestive cancers were studied at the following hospitals: Hospital General de México (HGM), Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirdn (INCMNSZ), Centro Médico Nacional 20 de Noviembre (CMN20Nov) and Hospital Español (HE). The diagnosis was established by histopathology study. Cases frequency is were compared in three-years intervals.


RESULTS
8,879 digestive cancers were documented. Gastric cancer frequency decreased during the study period at HGM (59% in 1978 to 38% in 2003) and at INCMNSZ (32% in 1978 to 24% in 2003), p = 0.013 andp = 0.012 respectively. Colon cancer frequency increased significantly at HGM (15% in 1978 to 36% in 2003, p < 0.001) and at CMN20Nov (20% in 1981 to 51% in 2003, p < 0.01) and at INCMNSZ with tower significancy. A change in squamous esophageal cancer (SC) and esophageal adenocarcinoma (EA) frequencies was observed in at the INCMNSZ, with a SC:EA ratio of 7:1 between 1977 to 1987and 1:2 between 1988 to 2005. Alimentary habits questionnaries showed early during the study diferences in caloric intake between the four hospitals (mean HGM: 2,169 kcal, INCMNSZ: 2,195 kcal, CMN2O0Nov: 3,133 y 2,262 kcal HE) and in animal protein intake, being lower at HGM (9.3 g/day) and IN-CMNSZ (11.8 g/day) compared with CMN2ONov (45.6 g/day) and HE (63.4 g/day), in the next questionnary these differences dissapeared and there was an increase in both, the same was observed for lipid intake.


CONCLUSIONS
We observed a reduction in gastric cancer fre quency and an increase in colon cancer in 25 years, probably associated to a change in habits dietary. Also a change in the main histological type of esophageal cancer was observed, initially epidermoid cancer was the most frequent and in the last 10 years adenocarcinoma is the most frequent.
Pérez
J Jesús Villalobos
JJ
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga No. 15, Tlalpan 14000, México, D.F.
Martínez
Marco A Olivera
MA
del Castillo
Aurora Loaeza
AL
Villalobos
M Luisa
ML
Villalobos
Gonzalo M Torres
GM
D000230:Adenocarcinoma / Q000453:epidemiology / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology / Q000473:pathology; D003110:Colonic Neoplasms / Q000453:epidemiology / Q000473:pathology; D004032:Diet; D004435:Eating; D004938:Esophageal Neoplasms / Q000453:epidemiology / Q000473:pathology; D005247:Feeding Behavior; D005770:Gastrointestinal Neoplasms / Q000453:epidemiology* / Q000473:pathology; D006801:Humans; D008800:Mexico / Q000453:epidemiology; D013274:Stomach Neoplasms / Q000453:epidemiology / Q000473:pathology