title: Vasopressor therapy using vasopressin prior to crystalloid resuscitation in irreversible hemorrhagic shock under isoflurane anesthesia in dogs.
abstract: In the present study, we tested the hypothesis that vasopressin administration prior to crystalloid resuscitation can be used to improve hemodynamic and oxygen delivery functions. Hemorrhagic shock was experimentally induced by maintaining mean arterial pressure at 60 mmHg for 30 min in sixteen healthy dogs weighing from 8 to 10.6 kg. Vasopressin was administered and then volume resuscitation was performed for the 6 dogs of V-C group, while vasopressin was administered at the end of volume resuscitation in the 5 dogs of C-V group. The control group (n=5) was administered 0.4 IU/kg of vasopressin after induction of shock without fluid resuscitation. In all groups, hemodynamic parameters were measured pre- and post-hemorrhage and for 60 min after fluid resuscitation. The dogs in V-C group had substantially increased systolic arterial pressure (SAP) for 60 min and improved pulmonary capillary wedge pressure (PCWP), cardiac output (CO), oxygen delivery, and oxygen consumption indexes compared with C-V and control groups. Diastolic pressure and systemic vascular resistance was significantly lower in the V-C group than those in the C-V and control groups (P<0.05). In the V-C group, there was effective and rapid restoration of the SAP, CO, PCWP, and oxygen delivery parameters after treatment. This study indicates that vasopressin administration before crystalloid resuscitation is a more efficient way of improving hemodynamic and oxygen delivery functions in hemorrhagic shock in dogs.
authors.affiliation: Department of Veterinary Internal Medicine, College of Veterinary Medicine, Seoul National University, Seoul, South Korea.
authors.forename: Jong-Hyun
authors.initials: JH
authors.lastname: Yoo
authors.forename: Min-Su
authors.initials: MS
authors.lastname: Kim
authors.forename: Ki-Dong
authors.initials: KD
authors.lastname: Eom
authors.forename: Jong-Im
authors.initials: JI
authors.lastname: Park
authors.forename: Chul
authors.initials: C
authors.lastname: Park
authors.forename: Hee-Myung
authors.initials: HM
authors.lastname: Park
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D000077324:Crystalloid Solutions; D004283:Dog Diseases / Q000188:drug therapy* / Q000628:therapy; D004285:Dogs; D007530:Isoflurane / Q000008:administration & dosage; D007552:Isotonic Solutions / Q000627:therapeutic use*; D010101:Oxygen Consumption / Q000187:drug effects; D012151:Resuscitation / Q000662:veterinary*; D012771:Shock, Hemorrhagic / Q000628:therapy / Q000662:veterinary*; D014655:Vascular Resistance / Q000187:drug effects; D014667:Vasopressins / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D000077324:Crystalloid Solutions; D007552:Isotonic Solutions; D014667:Vasopressins; D007530:Isoflurane