Activation of neutrophils by a novel triggering immunoglobulin-like receptor MAIR-IV.
Neutrophils play a central role in host defenses against infectious microbial pathogens. However, molecular basis for their triggering signals has been incompletely understood. Here, we show molecular and functional characteristics of myeloid-associated immunoglobulin-like receptor (MAIR)-IV. MAIR-IV was preferentially expressed on neutrophils in the peripheral blood, bone marrow, peritoneal cavity and spleen. MAIR-IV physically associates with immunoreceptor tyrosine based activating motif (ITAM)-bearing adaptor FcRgamma chain. Cross-linking MAIR-IV with anti-MAIR-IV monoclonal antibody significantly induced secretion of proinflammatory cytokines TNF-alpha and IL-6 from neutrophils. Thus, MAIR-IV may regulate activation of neutrophils and play an important role for innate immunity.
Nakano
Takako
T
Department of Immunology, Institute of Basic Medical Sciences and Center for TARA, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki 305-8575, Japan.
Tahara-Hanaoka
Satoko
S
Nakahashi
Chigusa
C
Can
Ismail
I
Totsuka
Naoya
N
Honda
Shin-ichiro
S
Shibuya
Kazuko
K
Shibuya
Akira
A
D000818:Animals; D033481:Chromosomes, Mammalian; D016207:Cytokines / Q000378:metabolism; D006801:Humans; D008264:Macrophages / Q000378:metabolism; D051379:Mice; D018375:Neutrophil Activation / Q000276:immunology*; D009504:Neutrophils / Q000378:metabolism; D011485:Protein Binding; D017452:Receptors, IgG / Q000276:immunology; D019056:Receptors, Polymeric Immunoglobulin / Q000276:immunology*
D016207:Cytokines; C524158:MAIR-IV protein, mouse; D017452:Receptors, IgG; D019056:Receptors, Polymeric Immunoglobulin