title: Chiari I malformation and idiopathic growth hormone deficiency in siblings: report of three cases.
abstract: BACKGROUND
  The authors report a case of three brothers.
  
  
  METHODS
  Two of these siblings presented with congenital growth hormone deficiency (GHD) and Chiari I malformation (CIM). The third younger brother has been found not to have GHD or the CIM.
  
  
  CONCLUSIONS
  Sparse cases of these two clinical occurrences have been reported. Further, the posterior cranial fossa (PF) has been determined to be altered in patients with CIM and GHD.
  
  
  CONCLUSIONS
  Our current case reports strengthen the association between these two pathological entities and, to our knowledge, is the first description of both defects in siblings.
authors.affiliation: University of Alabama School of Medicine, Birmingham, AL 35233, USA.
authors.forename: R Lee
authors.initials: RL
authors.lastname: Murphy
authors.forename: R Shane
authors.initials: RS
authors.lastname: Tubbs
authors.forename: Paul A
authors.initials: PA
authors.lastname: Grabb
authors.forename: W Jerry
authors.initials: WJ
authors.lastname: Oakes
mesh_terms: D001139:Arnold-Chiari Malformation / Q000503:physiopathology*; D002648:Child; D002675:Child, Preschool; D004677:Encephalocele / Q000209:etiology / Q000473:pathology; D013006:Growth Hormone / Q000627:therapeutic use; D019382:Human Growth Hormone / Q000172:deficiency*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D012249:Rhombencephalon / Q000473:pathology; D012600:Scoliosis / Q000209:etiology; D013595:Syringomyelia / Q000209:etiology
chemical_list: D019382:Human Growth Hormone; D013006:Growth Hormone