Matrix metalloproteinase-9 and tissue inhibitors of metalloproteinases 1 in influenza-associated encephalopathy.
Matrix metalloproteinase-9 (MMP-9) and tissue inhibitors of metalloproteinases 1 (TIMP-1) play important roles in the function of the blood-brain barrier. Serum MMP-9 and TIMP-1 concentrations were determined in influenza virus infection with or without neurologic complications. Our results suggest that an imbalance between MMP-9 and TIMP-1 damages the blood-brain barrier and promotes febrile seizure or encephalopathy in influenza virus infection.
Ichiyama
Takashi
T
Department of Pediatrics, Yamaguchi University School of Medicine, Yamaguchi, Japan. ichiyama@yamaguchi-u.ac.jp
Morishima
Tsuneo
T
Kajimoto
Madoka
M
Matsushige
Takeshi
T
Matsubara
Tomoyo
T
Furukawa
Susumu
S
D000293:Adolescent; D001812:Blood-Brain Barrier / Q000502:physiology; D002648:Child; D002675:Child, Preschool; D018792:Encephalitis, Viral / Q000201:enzymology* / Q000473:pathology; D005260:Female; D006801:Humans; D007223:Infant; D007251:Influenza, Human / Q000150:complications / Q000201:enzymology*; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000097:blood*; D003294:Seizures, Febrile; D019715:Tissue Inhibitor of Metalloproteinase-1 / Q000097:blood*
D019715:Tissue Inhibitor of Metalloproteinase-1; D020780:Matrix Metalloproteinase 9