Antiphospholipid antibodies in response to infection.
An association between infections and antiphospholipid antibodies (aPL) has been reported in several epidemiologic and experimental studies. Infection-induced aPL have been traditionally regarded as transient and were generally not associated with clinical features of antiphospholipid syndrome. The distinction between autoimmune and postinfectious aPL on the basis of requirement of binding cofactor is not absolute, and in recent years, several reports demonstrated that some patients can produce pathogenic antibodies in response to infection. Infections most frequently associated with antiphospholipid syndrome include parvovirus B19, cytomegalovirus, varicella-zoster virus, HIV, streptococcal and staphylococcal infections, gram-negative bacteria, and Mycoplasma pneumoniae.
Avcin
Tadej
T
Department of Allergology, Rheumatology and Clinical Immunology, University Children's Hospital, University Medical Center Ljubljana, Vrazov trg 1, SI-1525 Ljubljana, Slovenia. tadej.avcin@kclj.si
Toplak
Natasa
N
D000818:Animals; D017152:Antibodies, Antiphospholipid / Q000276:immunology*; D000917:Antibody Formation; D016736:Antiphospholipid Syndrome / Q000150:complications* / Q000503:physiopathology; D001424:Bacterial Infections / Q000150:complications / Q000276:immunology*; D004195:Disease Models, Animal; D006801:Humans; D010272:Parasitic Diseases / Q000150:complications / Q000276:immunology*; D014777:Virus Diseases / Q000150:complications / Q000276:immunology*
D017152:Antibodies, Antiphospholipid