Morita-Baylis-Hillman reaction of masked 5-alkylidene-2-cyclopentenones: general entry to 5-alkylidene-2-(hydroxyalkyl)- 2-cyclopentenones.
The reaction of masked 5-alkylidene-2-cyclopentenones with aldehydes catalyzed by tributylphosphine in the presence of phenol provided the corresponding Morita-Baylis-Hillman adducts, which were subjected to flash vacuum pyrolysis to afford 5-alkylidene-2-(hydroxyalkyl)-2-cyclopentenones.
Pohmakotr
Manat
M
Department of Chemistry, Faculty of Science, Mahidol University, Rama VI Road, Bangkok 10400, Thailand. scmpk@mahidol.ac.th
Thamapipol
Sirinporn
S
Tuchinda
Patoomratana
P
Prabpai
Samran
S
Kongsaeree
Palangpon
P
Reutrakul
Vichai
V