Relative cerebral blood volume is a measure of angiogenesis in brain tuberculoma.
OBJECTIVE
The aim of this study was to correlate the perfusion indices with magnetic resonance imaging-derived cellular and necrotic fraction of the tuberculoma and angiogenesis metrics on histopathology.


METHODS
We performed dynamic contrast-enhanced magnetic resonance imaging in 13 excised brain tuberculoma patients. Microvascular density and vascular endothelial growth factor (VEGF)-expressing cells were quantified from the excised tuberculoma. The cellular and necrotic fractions of the tuberculomas were quantified on a postcontrast T1-weighted imaging.


RESULTS
Relative cerebral blood volume of cellular portion significantly correlated with cellular fraction volume (r = 0.882, P < 0.001), microvascular density (r = 0.900, P < 0.001), and VEGF (r = 0.886, P < 0.001) of the 13 excised tuberculomas. Microvascular density also correlated significantly with VEGF (r = 0.919, P < 0.001).


CONCLUSIONS
Relative cerebral blood volume is a measure of angiogenesis in the cellular fraction of the brain tuberculoma. This information may be of value in predicting the therapeutic response in future.
Gupta
Rakesh K
RK
Department of Radiodiagnosis, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India. rgupta@sgpgi.ac.in
Haris
Mohammad
M
Husain
Nuzhat
N
Husain
Mazhar
M
Prasad
Kashi N
KN
Pauliah
Mohan
M
Srivastava
Chhitiz
C
Tripathi
Mukesh
M
Rastogi
Manu
M
Behari
Sanjay
S
Singh
Anup
A
Rathore
Divya
D
Rathore
Ram Kishore S
RK
D000293:Adolescent; D000328:Adult; D001810:Blood Volume; D002648:Child; D002675:Child, Preschool; D003287:Contrast Media; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008833:Microcirculation; D009336:Necrosis; D009389:Neovascularization, Pathologic / Q000473:pathology*; D016862:Tuberculoma, Intracranial / Q000473:pathology*; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
D003287:Contrast Media; D042461:Vascular Endothelial Growth Factor A; C064925:gadodiamide; D019786:Gadolinium DTPA