Integrin beta 3 genotype influences asthma and allergy phenotypes in the first 6 years of life.
BACKGROUND
The integrin beta3 gene (ITGB3) encodes a subunit of the platelet and monocyte-specific fibrinogen receptor and the widely expressed vitronectin receptor, which have diverse roles in cell migration, adhesion, and signaling. Previous work from our laboratory reported associations between single nucleotide polymorphisms (SNPs) in ITGB3 and asthma and allergic sensitization in 4 populations.


OBJECTIVE
To examine whether SNPs in ITGB3 are associated with the development of asthma and allergic phenotypes in early life.


METHODS
We typed 13 SNPs in 206 children participating in a birth cohort study and tested for associations with asthma and allergy phenotypes in the first 6 years of life.


RESULTS
Our study revealed significant associations between SNPs in ITGB3 and asthma, wheezing, and IgE levels, suggesting an early role for this gene in the development of asthma and allergy. In particular, SNPs at the 3' end of the gene were significantly associated with IgE levels beginning at 1 year of age, whereas a SNP in intron 1 showed significant interaction effects with viral respiratory illness in infancy on asthma susceptibility.


CONCLUSIONS
Our results suggest that genetic variation in ITGB3 contributes to asthma susceptibility and allergic sensitization, and that the effects of this gene begin early in life. Similar to our earlier study, different SNPs in the gene are associated with asthma and IgE.


CONCLUSIONS
ITGB3 may play an important role in the development of asthma and allergy and may represent a potential therapeutic target for the treatment of these disorders.
Thompson
Emma E
EE
Department of Human Genetics, University of Chicago, Chicago, Ill., USA. eethomps@uchicago.edu
Pan
Lin
L
Ostrovnaya
Irina
I
Weiss
Lauren A
LA
Gern
James E
JE
Lemanske
Robert F
RF
Nicolae
Dan L
DL
Ober
Carole
C
D000375:Aging / Q000235:genetics / Q000276:immunology*; D001249:Asthma / Q000235:genetics* / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000235:genetics / Q000276:immunology; D016130:Immunophenotyping; D007223:Infant; D039661:Integrin beta3 / Q000235:genetics* / Q000502:physiology; D020641:Polymorphism, Single Nucleotide; D012130:Respiratory Hypersensitivity / Q000235:genetics* / Q000276:immunology; D012135:Respiratory Sounds / Q000235:genetics / Q000276:immunology
C061248:ITGB3 protein, human; D039661:Integrin beta3