title: [Frontotemporal dementia].
abstract: Frontotemporal dementia usually begins before the age of 65 years. It is manifested by behavioral and language disorders. The lesions observed in frontotemporal dementia affect the frontal and temporal lobes bilaterally. One third of patients have a psychiatric diagnosis at the onset of disease. The genetic component is important: 30-50% of patients have a family history of this disease. Cholinergic effects are not associated with frontotemporal dementia and therefore anticholinesterase treatment is not indicated.
authors.affiliation: Inserm U679, Neurology and Experimental Therapeutics, Paris (75). leber@ccr.jussieu.fr
authors.forename: Isabelle
authors.initials: I
authors.lastname: Le Ber
authors.forename: Bruno
authors.initials: B
authors.lastname: Dubois
mesh_terms: D000251:Adenosine Triphosphatases / Q000235:genetics; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000175:diagnosis; D000690:Amyotrophic Lateral Sclerosis / Q000150:complications; D018888:Aphasia, Primary Progressive / Q000150:complications; D001921:Brain / Q000000981:diagnostic imaging; D018797:Cell Cycle Proteins / Q000235:genetics; D003704:Dementia / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000235:genetics / Q000628:therapy; D003937:Diagnosis, Differential; D005473:Fluoxetine / Q000627:therapeutic use; D005625:Frontal Lobe; D006801:Humans; D008869:Microtubule-Associated Proteins / Q000235:genetics; D008875:Middle Aged; D020734:Parkinsonian Disorders / Q000150:complications; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use; D013702:Temporal Lobe; D015899:Tomography, Emission-Computed, Single-Photon; D014057:Tomography, X-Ray Computed; D014196:Trazodone / Q000627:therapeutic use; D000074405:Valosin Containing Protein
chemical_list: D000251:Adenosine Triphosphatases; D018797:Cell Cycle Proteins; D005473:Fluoxetine; D008869:Microtubule-Associated Proteins; D017367:Selective Serotonin Reuptake Inhibitors; D014196:Trazodone; D000074405:Valosin Containing Protein