Angioimmunoblastic T-cell lymphoma developed with lymphocytic pleural effusion.
Angioimmunoblastic T-cell lymphoma (AILT) is a rare variant of nodal and aggressive lymphoma. It is sometimes difficult to distinguish AILT from reactive lymphoid hyperplasia from the histopathological aspect. We report a case of AILT which developed with bilateral pleural effusion. The effusion consisted predominately of small lymphoid cells. Analyses of the effusion showed trisomy 3, and rearranged bands of TCR beta gene. Flow cytometry showed a very small amount of CD10-positive cells. Although we could not further identify the tumor cells in this case, analysis of pleural effusion cells will increase our understanding of the pathogenesis and the pathophysiology of AILT.
Hosoki
Keisuke
K
Department of Respiratory Medicine, Katta General Hospital, Shiroishi.
Okada
Shinji
S
Ichinohasama
Ryo
R
Yamaguchi
Masaaki
M
Uchiyama
Bine
B
Maeyama
Toshihide
T
D000369:Aged, 80 and over; D002893:Chromosomes, Human, Pair 3 / Q000235:genetics; D015321:Gene Rearrangement / Q000235:genetics; D019674:Genes, T-Cell Receptor beta / Q000235:genetics; D006801:Humans; D007119:Immunoblastic Lymphadenopathy / Q000150:complications* / Q000175:diagnosis / Q000235:genetics / Q000276:immunology; D016399:Lymphoma, T-Cell / Q000150:complications* / Q000175:diagnosis / Q000235:genetics / Q000276:immunology; D008297:Male; D015260:Neprilysin / Q000378:metabolism; D016066:Pleural Effusion, Malignant / Q000209:etiology* / Q000473:pathology; D014314:Trisomy / Q000235:genetics
D015260:Neprilysin