AHSG gene polymorphisms are associated with bone mineral density in Caucasian nuclear families.
OBJECTIVE
To investigate the role of alpha2-HS glycoprotein (AHSG) gene on bone mineral density (BMD) variation.


METHODS
A total of 665 subjects from 157 Caucasian nuclear families were genotyped at the AHSG NlaIII, SacI sites. The association and linkage between the single SNP markers and haplotypes constructed by two markers in this gene and BMDs at the spine and hip were determined by using quantitative transmission disequilibrium test (QTDT).


RESULTS
Significant within-family associations were obtained for spine BMD at both of studied markers (P = 0.036 and 0.005 at the NlaIII and SacI sites, respectively). Significant (P = 0.008 at the NlaIII locus) (P = 0.004 at the SacI locus) total associations at spine BMD were detected. Haplotype analyses confirmed those within-family and total association.


CONCLUSIONS
These data suggest the polymorphisms in the AHSG gene may have effects on BMD variation in Caucasian population.
Yang
Yan-Jun
YJ
Laboratory of Molecular and Statistical Genetics and the Key Laboratory of Protein Chemistry and Developmental Biology of the Ministry of Education, College of Life Sciences, Hunan Normal University, Changsha, Hunan, 410081, PR China.
Wang
Yan-Bo
YB
Lei
Shu-Feng
SF
Long
Ji-Rong
JR
Shen
Hui
H
Zhao
Lan-Juan
LJ
Jiang
De-Ke
DK
Xiao
Su-Mei
SM
Chen
Xiang-Ding
XD
Chen
Yuan
Y
Deng
Hong-Wen
HW
D000328:Adult; D001798:Blood Proteins / Q000235:genetics*; D015519:Bone Density / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D008040:Genetic Linkage; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D009329:Nebraska; D009679:Nuclear Family; D010024:Osteoporosis / Q000235:genetics*; D011110:Polymorphism, Genetic; D044465:White People / Q000235:genetics*; D060749:alpha-2-HS-Glycoprotein
C556354:AHSG protein, human; D001798:Blood Proteins; D060749:alpha-2-HS-Glycoprotein