Chronic lymphocytic leukemia: keeping cell death at bay.
Chronic lymphocytic leukemia (CLL) is a common adult leukemia caused by abnormal accumulation of B cells. Raval et al. (2007) now implicate dowregulation of the expression of the kinase DAPK1 both genetically and epigenetically in familial and sporadic CLL.
Debatin
Klaus-Michael
KM
Department of Pediatrics and Adolescent Medicine, University of Ulm, Eythstrasse 24, 89075, Ulm. klaus-michael.debatin@uniklinik-ulm.de
D000818:Animals; D017209:Apoptosis; D051017:Apoptosis Regulatory Proteins / Q000235:genetics*; D001402:B-Lymphocytes / Q000166:cytology; D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000235:genetics*; D064550:Death-Associated Protein Kinases; D044127:Epigenesis, Genetic; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000188:drug therapy / Q000235:genetics*; D051379:Mice
D051017:Apoptosis Regulatory Proteins; C579096:DAPK1 protein, human; C579106:Dapk1 protein, mouse; D064550:Death-Associated Protein Kinases; D017871:Calcium-Calmodulin-Dependent Protein Kinases