title: [Expression of Survivin and its significance in tongue squamous cell carcinoma].
abstract: OBJECTIVE
  To investigate the expression of Survivin,one of inhibitors of apoptosis proteins(IAPs) in tongue squamous cell carcinoma(TSCC), and discuss its clinical significance.
  
  
  METHODS
  Immunohistochemical staining was employed to detect the expression of Survivin in 10 normal lingual mucosal membranes, 13 highly differentiated SCCs,20 medium-differentiated SCCs and 12 low-differentiated SCCs. Data was analyzed with SPSS13 software package for nonparametric Kruskal-Wallis test and Mann-Whitney U test.
  
  
  RESULTS
  The positive staining rate of Survivin in TSCC was 68.9%, and significantly higher than that in normal control group (P<0.01). Overexpression of Survivin was related to the pathological grade, TNM stage (P<0.05) and closely to lymph node metastasis of TSCC (P<0.01).
  
  
  CONCLUSIONS
  The positive staining of Survivin increased in different grades of TSCC, and Survivin is relative to carcinogenesis, progression and prognosis of TSCC. It may be a new clinical therapeutic target for TSCC.
authors.affiliation: Department of Stomatology, Shengjing Hospital, China Medical University, Shenyang 110004, Liaoning Province, China. w_eve@sina.com
authors.forename: Zhi-ming
authors.initials: ZM
authors.lastname: Wang
authors.forename: Fang
authors.initials: F
authors.lastname: Liu
authors.forename: Xin-ming
authors.initials: XM
authors.lastname: Guan
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Zhang
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000378:metabolism*; D018450:Disease Progression; D006801:Humans; D007150:Immunohistochemistry; D051034:Inhibitor of Apoptosis Proteins / Q000378:metabolism*; D008207:Lymphatic Metastasis; D009367:Neoplasm Staging; D011379:Prognosis; D000077022:Survivin; D014062:Tongue Neoplasms / Q000378:metabolism*
chemical_list: C107489:BIRC5 protein, human; D051034:Inhibitor of Apoptosis Proteins; D000077022:Survivin