title: Primary progressive multiple sclerosis: a comparative study of the diagnostic criteria.
abstract: We assessed the different sets of diagnostic criteria for primary progressive multiple sclerosis (PPMS), in order to determine their sensitivity when applied to a cohort of 261 PPMS patients. According to the Thompson criteria, 168 patients (64.4%) had definite PPMS, 84 patients (32.2%) had probable PPMS, and nine patients (3.4%) had possible PPMS; according to the McDonald criteria, 180 patients (69%) had PPMS; according to the revised McDonald criteria, 194 patients (74.3%) had PPMS. Our findings indicate that the revised McDonald criteria are more sensitive than the original McDonald criteria, but less sensitive than the Thompson criteria.
authors.affiliation: Department of Neurology, Hôpital Civil, Strasbourg, France. jerome.de.seze@chru-strasbourg.fr
authors.forename: J
authors.initials: J
authors.lastname: de Seze
authors.forename: M
authors.initials: M
authors.lastname: Debouverie
authors.forename: N
authors.initials: N
authors.lastname: Waucquier
authors.forename: G
authors.initials: G
authors.lastname: Steinmetz
authors.forename: S
authors.initials: S
authors.lastname: Pittion
authors.forename: H
authors.initials: H
authors.lastname: Zephir
authors.forename: M
authors.initials: M
authors.lastname: Fleury
authors.forename: F
authors.initials: F
authors.lastname: Blanc
authors.forename: P
authors.initials: P
authors.lastname: Vermersch
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D020528:Multiple Sclerosis, Chronic Progressive / Q000145:classification* / Q000175:diagnosis*; D017410:Practice Guidelines as Topic; D012189:Retrospective Studies; D012680:Sensitivity and Specificity