Performance of an automated segmentation algorithm for 3D MR renography.
The accuracy and precision of an automated graph-cuts (GC) segmentation technique for dynamic contrast-enhanced (DCE) 3D MR renography (MRR) was analyzed using 18 simulated and 22 clinical datasets. For clinical data, the error was 7.2 +/- 6.1 cm(3) for the cortex and 6.5 +/- 4.6 cm(3) for the medulla. The precision of segmentation was 7.1 +/- 4.2 cm(3) for the cortex and 7.2 +/- 2.4 cm(3) for the medulla. Compartmental modeling of kidney function in 22 kidneys yielded a renal plasma flow (RPF) error of 7.5% +/- 4.5% and single-kidney GFR error of 13.5% +/- 8.8%. The precision was 9.7% +/- 6.4% for RPF and 14.8% +/- 11.9% for GFR. It took 21 min to segment one kidney using GC, compared to 2.5 hr for manual segmentation. The accuracy and precision in RPF and GFR appear acceptable for clinical use. With expedited image processing, DCE 3D MRR has the potential to expand our knowledge of renal function in individual kidneys and to help diagnose renal insufficiency in a safe and noninvasive manner.
Rusinek
Henry
H
Department of Radiology, New York University School of Medicine, New York, NY 10016, USA. hr18@nyu.edu
Boykov
Yuri
Y
Kaur
Manmeen
M
Wong
Samson
S
Bokacheva
Louisa
L
Sajous
Jan B
JB
Huang
Ambrose J
AJ
Heller
Samantha
S
Lee
Vivian S
VS
D000328:Adult; D000368:Aged; D000465:Algorithms; D003198:Computer Simulation; D003287:Contrast Media; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional; D007674:Kidney Diseases / Q000175:diagnosis*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D012079:Renal Circulation
D003287:Contrast Media; D019786:Gadolinium DTPA