title: Subcutaneous injection of heparin calcium controls chronic disseminated intravascular coagulation associated with inoperable dissecting aortic aneurysm in an outpatient clinic.
abstract: BACKGROUND
  Chronic disseminated intravascular coagulation (DIC) is a rare but critical complication of aortic aneurysm, and can represent a difficult long-term management problem. Although surgical correction is the treatment of choice, alternative therapy is required for inoperable patients.
  
  
  RESULTS
  We report herein a case of acute exacerbation of chronic DIC with inoperable dissecting aortic aneurysm, which was recurrent and resistant to regular treatment. Intermittent subcutaneous self-injection of heparin calcium 15,000 units per day achieved stabilization of coagulation and fibrinolytic parameters and relief of the bleeding tendency.
  
  
  CONCLUSIONS
  Subcutaneous heparin injection can be an alternative treatment for long-term management of chronic DIC associated with inoperable aortic dissection, beneficial for providing good symptomatic control on an outpatient basis.
authors.affiliation: Cardiovascular Division, First Department of Integrated Medicine, Jichi Medical University, Omiya Medical Center, Saitama.
authors.forename: Shoko
authors.initials: S
authors.lastname: Miyahara
authors.forename: Takanori
authors.initials: T
authors.lastname: Yasu
authors.forename: Yoko
authors.initials: Y
authors.lastname: Yamada
authors.forename: Nobuhiko
authors.initials: N
authors.lastname: Kobayashi
authors.forename: Muneyasu
authors.initials: M
authors.lastname: Saito
authors.forename: Shin-ichi
authors.initials: S
authors.lastname: Momomura
mesh_terms: D000554:Ambulatory Care Facilities; D000784:Aortic Dissection / Q000150:complications*; D000925:Anticoagulants / Q000008:administration & dosage / Q000627:therapeutic use*; D001014:Aortic Aneurysm / Q000150:complications*; D004211:Disseminated Intravascular Coagulation / Q000188:drug therapy* / Q000209:etiology*; D006493:Heparin / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007279:Injections, Subcutaneous; D008297:Male; D008875:Middle Aged
chemical_list: D000925:Anticoagulants; D006493:Heparin