title: Exploiting a list of protein sequences.
abstract: We describe a software program to help exploit a database of aligned protein sequences. In addition to the classical lists of sequences, a graphical representation is used to get a better overview of the information. As natural parameters, the type of amino acid and sequence position are used. Various plots or 3D representations are then updated. Examples are shown based on globin sequences from various species and on the abnormal human hemoglobins. The software should be of interest to protein engineers who need to know what variants are already known.
authors.affiliation: Department of Biomedical Sciences, University of Antwerp, B-2610 Antwerp, Belgium. marden@kb.inserm.fr
authors.forename: Michael C
authors.initials: MC
authors.lastname: Marden
authors.forename: Sylvia
authors.initials: S
authors.lastname: Dewilde
authors.forename: Laurent
authors.initials: L
authors.lastname: Kiger
authors.forename: Djemel
authors.initials: D
authors.lastname: Hamdane
authors.forename: Julien
authors.initials: J
authors.lastname: Uzan
authors.forename: Thorsten
authors.initials: T
authors.lastname: Burmester
authors.forename: Thomas
authors.initials: T
authors.lastname: Hankeln
authors.forename: Luc
authors.initials: L
authors.lastname: Moens
authors.forename: Véronique
authors.initials: V
authors.lastname: Baudin-Creuza
authors.forename: Chantal
authors.initials: C
authors.lastname: Celier
authors.forename: Henri
authors.initials: H
authors.lastname: Wajcman
mesh_terms: D000595:Amino Acid Sequence; D000596:Amino Acids / Q000737:chemistry / Q000235:genetics; D000818:Animals; D003196:Computer Graphics; D030562:Databases, Protein; D006454:Hemoglobins / Q000737:chemistry* / Q000235:genetics; D006801:Humans; D008958:Models, Molecular; D009154:Mutation; D011487:Protein Conformation; D017434:Protein Structure, Tertiary; D012984:Software
chemical_list: D000596:Amino Acids; D006454:Hemoglobins