title: The effect of short-term use of testosterone enanthate on muscular strength and power in healthy young men.
abstract: Use of testosterone enanthate has been shown to significantly increase strength within 6-12 weeks of administration (2, 9), however, it is unclear if the ergogenic benefits are evident in less than 6 weeks. Testosterone enanthate is classified as a prohibited substance by the World Anti-Doping Agency (WADA) and its use may be detected by way of the urinary testosterone/epitestosterone (T/E) ratio (16). The two objectives of this study were to establish (a) if injection of 3.5 mg.kg(-1) testosterone enanthate once per week could increase muscular strength and cycle sprint performance in 3-6 weeks; and (b) if the WADA-imposed urinary T/E ratio of 4:1 could identify all subjects being administered 3.5 mg.kg(-1) testosterone enanthate. Sixteen healthy young men were match-paired and were assigned randomly in a double-blind manner to either a testosterone enanthate or a placebo group. All subjects performed a structured heavy resistance training program while receiving either testosterone enanthate (3.5 mg.kg(-1)) or saline injections once weekly for 6 weeks. One repetition maximum (1RM) strength measures and 10-second cycle sprint performance were monitored at the pre (week 0), mid (week 3), and post (week 6) time points. Body mass and the urinary T/E ratio were measured at the pre (week 0) and post (week 6) time points. When compared with baseline (pre), 1RM bench press strength and total work during the cycle sprint increased significantly at week 3 (p < 0.01) and week 6 (p < 0.01) in the testosterone enanthate group, but not in the placebo group. Body mass at week 6 was significantly greater than at baseline in the testosterone enanthate group (p < 0.01), but not in the placebo group. Despite the clear ergogenic effects of testosterone enanthate in as little as 3 weeks, 4 of the 9 subjects in the testosterone enanthate group ( approximately 44%) did not test positive to testosterone under current WADA urinary T/E ratio criteria.
authors.affiliation: School of Exercise and Sport Management, Southern Cross University, Lismore, New Wales, Australia. srogerson10@bigpond.com
authors.forename: Shane
authors.initials: S
authors.lastname: Rogerson
authors.forename: Robert P
authors.initials: RP
authors.lastname: Weatherby
authors.forename: Glen B
authors.initials: GB
authors.lastname: Deakin
authors.forename: Rudi A
authors.initials: RA
authors.lastname: Meir
authors.forename: Rosanne A
authors.initials: RA
authors.lastname: Coutts
authors.forename: Shi
authors.initials: S
authors.lastname: Zhou
authors.forename: Sonya M
authors.initials: SM
authors.lastname: Marshall-Gradisnik
mesh_terms: D000328:Adult; D045930:Anabolic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D000704:Analysis of Variance; D004300:Doping in Sports; D004311:Double-Blind Method; D005080:Exercise Test; D006801:Humans; D008297:Male; D053580:Muscle Strength / Q000187:drug effects*; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000378:metabolism; D010806:Physical Education and Training; D013739:Testosterone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D045930:Anabolic Agents; D013739:Testosterone; C004648:testosterone enanthate