Effect of formaldehyde on rat liver in doses used in pulpotomies.
Many studies have questioned the toxic effects of formocresol, one of which is its systemic distribution. This study focused on determining whether there was risk of acute hepatic lesion after the use of intravenous formaldehyde in doses for multple pulpotomies in rats. Histological and biochemical changes were evaluated. Results showed that very high doses of formaldehyde injected into rats, doses that were much higher than those given for multiple pulp treatments in a single session in Pediatric Dentistry, showed no signs of liver toxicity.
Cortés
O
O
Department of Pediatric Dentistry, University of Murcia, Spain.
Fernández
J
J
Boj
J R
JR
Canalda
C
C
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D005566:Formocresols / Q000032:analysis / Q000633:toxicity*; D007275:Injections, Intravenous; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D011672:Pulpotomy / Q000009:adverse effects; D051381:Rats; D017207:Rats, Sprague-Dawley
D005566:Formocresols; C031025:formocresol; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase