title: Necrotizing pancreatitis.
abstract: Necrotizing pancreatitis continues to challenge clinicians, and few other medical subjects currently elicit as much debate. Host characteristics or underlying differences in pathophysiology that lead to pancreatic necrosis remain poorly understood. Severe pancreatitis follows a two-phase clinical course. The early first phase manifests the features of the systemic inflammatory response syndrome, and the second late phase is characterized by infectious complications. This article presents a multidisciplinary literature-based approach to the treatment of patients with necrotizing pancreatitis.
authors.affiliation: Section of Gastrointestinal Surgery, Department of Surgery, University of Pittsburgh School of Medicine, 497 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA. hughess2@upmc.edu
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Hughes
authors.forename: Georgios I
authors.initials: GI
authors.lastname: Papachristou
authors.forename: Michael P
authors.initials: MP
authors.lastname: Federle
authors.forename: Kenneth K
authors.initials: KK
authors.lastname: Lee
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D003937:Diagnosis, Differential; D006801:Humans; D008279:Magnetic Resonance Imaging; D010180:Pancreatectomy / Q000379:methods*; D019283:Pancreatitis, Acute Necrotizing / Q000175:diagnosis* / Q000628:therapy*; D012720:Severity of Illness Index; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents