Functional anatomy of motor urgency.
This PET H(2)(15)O study uses a reaching task to determine the neural basis of the unconscious motor speed up observed in the context of urgency in healthy subjects. Three conditions were considered: self-initiated (produce the fastest possible movement toward a large plate, when ready), externally-cued (same as self-initiated but in response to an acoustic cue) and temporally-pressing (same as externally-cued with the plate controlling an electromagnet that prevented a rolling ball from falling at the bottom of a tilted ramp). Results show that: (1) Urgent responses (Temporally-pressing versus Externally-cued) engage the left parasagittal and lateral cerebellar hemisphere and the sensorimotor cortex (SMC) bilaterally; (2) Externally-driven responses (Externally-cued versus Self-initiated) recruit executive areas within the contralateral SMC; (3) Volitional responses (Self-initiated versus Externally-cued) involve prefrontal cortical areas. These observations are discussed with respect to the idea that neuromuscular energy is set to a submaximal threshold in self-determined situations. In more challenging tasks, this threshold is raised and the first answer of the nervous system is to optimize the response of the lateral (i.e. crossed) corticospinal tract (contralateral SMC) and ipsilateral cerebellum. In a second step, the anterior (i.e. uncrossed) corticospinal tract (ipsilateral SMC) and the contralateral cerebellum are recruited. This recruitment is akin to the strategy observed during recovery in patients with brain lesions.
Thobois
Stéphane
S
Université Lyon I, Hospices Civils de Lyon, Hôpital Neurologique et Neurochirurgical Pierre Wertheimer, Neurologie C, Lyon, France. stephane.thobois@chu-lyon.fr
Ballanger
Bénédicte
B
Baraduc
Pierre
P
Le Bars
Didier
D
Lavenne
Franck
F
Broussolle
Emmanuel
E
Desmurget
Michel
M
D000161:Acoustic Stimulation; D000328:Adult; D001288:Attention / Q000502:physiology; D002531:Cerebellum / Q000000981:diagnostic imaging / Q000502:physiology*; D003463:Cues; D004292:Dominance, Cerebral / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009042:Motivation; D049268:Positron-Emission Tomography; D017397:Prefrontal Cortex / Q000000981:diagnostic imaging / Q000502:physiology*; D011597:Psychomotor Performance / Q000502:physiology*; D011712:Pyramidal Tracts / Q000000981:diagnostic imaging / Q000502:physiology; D011930:Reaction Time / Q000502:physiology*; D011999:Recruitment, Neurophysiological / Q000502:physiology; D013003:Somatosensory Cortex / Q000000981:diagnostic imaging / Q000502:physiology*