title: Stereoselective toxicokinetics and tissue distribution of ethofumesate in rabbits.
abstract: The stereoselective toxicokinetics of ethofumesate enantiomers following a single intravenous (i.v.) administration at doses of 30 mg/kg were investigated in rabbits. Plasma concentrations of (+)- and (-)-ethofumesate were analyzed by a validated chiral HPLC method that involved extraction of plasma with organic solvent followed by separation on a cellulose-Tris-(3,5-dimethylphenylcarbamate)-based chiral column and quantification by UV absorbance at 230 nm. Plasma concentration-time curves after i.v. administration were best described by an open two-compartment model. The concentration of the (-)-enantiomer decreased more rapidly than that of the (+)-enantiomer. Significant differences in toxicokinetic parameters between the two enantiomers indicated that stereoselective behavior occurred with the (-)-enantiomer being preferentially metabolized and eliminated.
authors.affiliation: Department of Applied Chemistry, China Agricultural University, Beijing, People's Republic of China.
authors.forename: Wentao
authors.initials: W
authors.lastname: Zhu
authors.forename: Ziheng
authors.initials: Z
authors.lastname: Dang
authors.forename: Jing
authors.initials: J
authors.lastname: Qiu
authors.forename: Chunguang
authors.initials: C
authors.lastname: Lv
authors.forename: Guifang
authors.initials: G
authors.lastname: Jia
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Zhou
mesh_terms: D000818:Animals; D001572:Benzofurans / Q000097:blood / Q000737:chemistry / Q000493:pharmacokinetics* / Q000633:toxicity*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D006540:Herbicides / Q000097:blood / Q000737:chemistry / Q000493:pharmacokinetics / Q000633:toxicity; D008297:Male; D008698:Mesylates / Q000097:blood / Q000737:chemistry / Q000493:pharmacokinetics* / Q000633:toxicity*; D011817:Rabbits; D013237:Stereoisomerism; D014018:Tissue Distribution
chemical_list: D001572:Benzofurans; D006540:Herbicides; D008698:Mesylates; C412911:ethofumesate