title: Clinical spectrum of gammadelta+ T cell LGL leukemia: analysis of 20 cases.
abstract: We report on the clinico-biological characteristics of 20 cases of gammadelta T cell large granular lymphocyte (LGL) leukemia. All the data were compared to that of 196 cases with alphabeta T cell subtype, which represents the majority of T cell LGL leukemias. Clinical findings were quite similar in the two groups regarding age, sex ratio, recurrent infections, and association with auto-immune diseases especially rheumatoid arthritis. Gammadelta LGL predominantly expressed a CD3+/CD4-/CD8+/CD16+/CD57+ phenotype, in 50% of cases. Clinical outcome was favorable for these patients with overall survival of 85% at 3 years. Fifty percent of gammadelta patients required treatment and the response to therapy was estimated at 55%. gammadelta and alphabeta T cell LGL leukemia harbor a very similar clinico-biological behavior and represent part of an antigen-driven T cell lymphoproliferation.
authors.affiliation: Service d'Hématologie Clinique, Rennes, France.
authors.forename: A S
authors.initials: AS
authors.lastname: Bourgault-Rouxel
authors.forename: T P
authors.initials: TP
authors.lastname: Loughran
authors.forename: R
authors.initials: R
authors.lastname: Zambello
authors.forename: P K
authors.initials: PK
authors.lastname: Epling-Burnette
authors.forename: G
authors.initials: G
authors.lastname: Semenzato
authors.forename: J
authors.initials: J
authors.lastname: Donadieu
authors.forename: L
authors.initials: L
authors.lastname: Amiot
authors.forename: T
authors.initials: T
authors.lastname: Fest
authors.forename: T
authors.initials: T
authors.lastname: Lamy
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001327:Autoimmune Diseases / Q000150:complications; D002999:Clone Cells; D005260:Female; D015334:Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor; D006801:Humans; D016130:Immunophenotyping; D015458:Leukemia, T-Cell / Q000175:diagnosis* / Q000276:immunology; D007970:Leukopenia / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D016693:Receptors, Antigen, T-Cell, alpha-beta; D016692:Receptors, Antigen, T-Cell, gamma-delta; D013163:Splenomegaly / Q000175:diagnosis
chemical_list: D016693:Receptors, Antigen, T-Cell, alpha-beta; D016692:Receptors, Antigen, T-Cell, gamma-delta