Helicobacter pylori infection in symptomatic HIV-seropositive and -seronegative patients: a case-control study.
We conducted a case-control study in a Greek hospital to evaluate the prevalence and morbidity of Helicobacter pylori in HIV-infected patients. HIV-seropositive patients were infected by H. pylori less often than HIV-seronegative controls [12/58 (20.7%) versus 38/58 (65.5%),p < 0.001]. The mean CD4 count was lower for H. pylori-negative than H. pylori-positive HIV-infected patients (p < 0.007). Also, among HIV patients, prior use of antibiotics or proton pump inhibitors was more common in those without H. pylori infection, however, this difference was not statistically significant (p = 0.06). The grading of the density of H. pylori infection and the grading of the histomorphological findings according to the Sydney classification were similar between HIV-seropositive and -seronegative patients with H. pylori infection.
Panos
George Z
GZ
First IKA Hospital, Athens, Greece.
Xirouchakis
Elias
E
Tzias
Vasilis
V
Charatsis
Gerasimos
G
Bliziotis
Ioannis A
IA
Doulgeroglou
Vasilis
V
Margetis
Nikos
N
Falagas
Matthew E
ME
D000328:Adult; D000368:Aged; D018791:CD4 Lymphocyte Count; D016022:Case-Control Studies; D005260:Female; D006115:Greece / Q000453:epidemiology; D015658:HIV Infections / Q000150:complications*; D016481:Helicobacter Infections / Q000150:complications / Q000453:epidemiology* / Q000382:microbiology; D016480:Helicobacter pylori / Q000302:isolation & purification; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence