A novel HLA-A*33 (A*3309) allele in a Caucasian family that differs at protein position 66 from HLA-A*3308.
A novel human leucocyte antigen (HLA)-A33 (HLA-A*3309) allele has been identified in a Caucasian family from Middle Europe using single allele-specific sequencing strategy. This allele is identical to the HLA-B*3308 allele except for one point mutation in exon 2 at codon 66 (AAA-->AAT), resulting in an amino acid change from lysine (K) to asparagine (N).
Altermann
W W
WW
Institute of Medical Immunology, Interbranch HLA-Laboratory, Martin Luther University Halle-Wittenberg, D-06097 Halle, Germany. buero.ghatt@medizin.uni-halle.de
Erhuma
M
M
Seliger
B
B
Schlaf
G
G
D000483:Alleles; D019943:Amino Acid Substitution; D001216:Asparagine / Q000378:metabolism; D001483:Base Sequence; D005091:Exons; D005190:Family; D015234:HLA-A Antigens / Q000737:chemistry / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D017354:Point Mutation; D044465:White People / Q000235:genetics*
D015234:HLA-A Antigens; D001216:Asparagine