Altered oxidant-antioxidant status in non-obese men with moderate essential hypertension.
BACKGROUND
Although a wide number of experimental evidences are available regarding oxidant-antioxidant disturbance in hypertension, clinical data supporting it is lacking in men in early stages of hypertension.


OBJECTIVE
The objective of the study was to evaluate oxidative status and antioxidant activities in males with stage I essential hypertension.


METHODS
Thirty hypertensives and 21 normotensives were included in the study. Protein carbonyl, reduced glutathione, glutathione peroxidase, catalase and fasting glucose were assessed in both the groups.


METHODS
Results were analyzed by student's 't' test and linear regression analysis test.


RESULTS
Plasma protein carbonyl and glutathione peroxidase were significantly increased and catalase and GSH were significantly reduced in the hypertensive group compared to normotensive subjects. There was a significant negative correlation between glutathione peroxidase and catalase in the test group.


CONCLUSIONS
The data from the present study indicates an alteration in oxidant-antioxidant status in non-obese men in early stages of essential hypertension.
Nandeesha
H
H
Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India.
Sathiyapriya
V
V
Bobby
Zachariah
Z
Pavithran
P
P
Agrawal
Aparna
A
Selvaraj
N
N
D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D001786:Blood Glucose / Q000378:metabolism; D002374:Catalase / Q000097:blood; D005978:Glutathione / Q000097:blood; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000378:metabolism*; D016014:Linear Models; D008297:Male; D009765:Obesity; D018384:Oxidative Stress; D050050:Protein Carbonylation; D012720:Severity of Illness Index
D000975:Antioxidants; D001786:Blood Glucose; D002374:Catalase; D005979:Glutathione Peroxidase; D005978:Glutathione