[Neumopathies in patients with primary immunodeficiencies in treatment with intravenous gammaglobulin].
BACKGROUND
The primary immunodeficiency diseases cause a deficit in the production of antibodies. The chronic sinopulmonary disease is common and their clinic symptoms are diverse (pneumonia, bronchiectasis).


OBJECTIVE
To know the frequency and type of pulmonary abnormalities in patients with primary immunodeficiency in treatment with intravenous immunoglobulin.


METHODS
24 files of patients with primary immunodeficiency were selected. Age, sex, primary immunodeficiency type, time of immunoglobulin treatment, chest X-ray finding, pulmonary computed tomography of high resolution (HRCT) and pulmonary function tests were registered. Measures of central tendency were calculated.


RESULTS
There was no predominance of gender; the average age was 14 years old. The common variable immunodeficiency and the Bruton's hypogammaglobulinemia represented 91% of the patients. The X-ray of thorax was abnormal in 33%, although there were not bronchiectasis. The high-resolution computed tomography scan (HRCT) was abnormal in 67%, and 75% had bronchiectasis.


CONCLUSIONS
The pulmonary complications are common despite therapy with intravenous immunoglobulin. The HRCT is better than X-ray in these patients.
Mogica Martínez
María Dolores
MD
Servicio de alergia e inmunologia clinica, Hospital de Especialidades. dmogica@aol.com
García Lara
Sergio
S
Silva Vera
Rosalia
R
Montaño Velázquez
Beatriz
B
Cruz Mérida
Aarón
A
Santibáñez Bustamante
Julio
J
Moreno Martínez
Juan Manuel
JM
D000293:Adolescent; D000328:Adult; D000361:Agammaglobulinemia / Q000150:complications / Q000628:therapy; D001987:Bronchiectasis / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000276:immunology / Q000503:physiopathology; D002648:Child; D002675:Child, Preschool; D017074:Common Variable Immunodeficiency / Q000150:complications / Q000628:therapy; D004198:Disease Susceptibility; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D007153:Immunologic Deficiency Syndromes / Q000150:complications* / Q000628:therapy; D008171:Lung Diseases / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000276:immunology / Q000503:physiopathology / Q000517:prevention & control; D008297:Male; D015995:Prevalence; D012129:Respiratory Function Tests; D014057:Tomography, X-Ray Computed; D053632:X-Linked Combined Immunodeficiency Diseases / Q000150:complications / Q000628:therapy
D016756:Immunoglobulins, Intravenous