title: The use of oscillometry as a measure of airway responsiveness in asthmatic children after histamine and methacholine bronchoprovocation with dosimeter-MedicAid and DeVilbiss nebulizers.
abstract: To explore the use of oscillometry as a measure of airway responsiveness, 69 asthmatic children underwent histamine and methacholine bronchoprovocation using dosimeter-MedicAid (Jaeger Co.; Germany) and DeVilbiss nebulizers (DeVilbiss, Bornemouth; England). The mean increase in R5 resistance in challenge testing measured after methacholine with the dosimeter-MedicAid nebulizer was 77.14% compared with 65.05% using histamine. Using the dosimeter-DeVilbiss nebulizer, the mean increases in R5 resistance following methacholine and histamine testing were 57.50% and 59.36%, respectively. The resistance R5 over R20 significantly correlated with forced expiratory volume in 1 second (FEV1). The MedicAid produced a more aggressive challenge than the DeVilbliss nebulizer. Oscillometry can be used to monitor the level of airway hyperresponsiveness following bronchoprovocation tests.
authors.affiliation: Department of Pediatrics of Palacky University, Olomouc, Czech Republic. Koprivaf@FNOL.cz
authors.forename: F
authors.initials: F
authors.lastname: Kopriva
authors.forename: J
authors.initials: J
authors.lastname: Szotkowská
authors.forename: A
authors.initials: A
authors.lastname: Plocová
authors.forename: J
authors.initials: J
authors.lastname: Závodská
authors.forename: M
authors.initials: M
authors.lastname: Zápalka
authors.forename: D
authors.initials: D
authors.lastname: Smatanová
authors.forename: M
authors.initials: M
authors.lastname: Látalová
authors.forename: L
authors.initials: L
authors.lastname: Slezáková
authors.forename: L
authors.initials: L
authors.lastname: Radová
mesh_terms: D000293:Adolescent; D001249:Asthma / Q000175:diagnosis* / Q000503:physiopathology; D016535:Bronchial Hyperreactivity / Q000175:diagnosis / Q000503:physiopathology; D001985:Bronchial Provocation Tests / Q000295:instrumentation; D002648:Child; D005260:Female; D006632:Histamine; D006801:Humans; D008297:Male; D016210:Methacholine Chloride; D009330:Nebulizers and Vaporizers; D009991:Oscillometry; D013147:Spirometry
chemical_list: D016210:Methacholine Chloride; D006632:Histamine