title: Urachal duct remnant-like umbilical clear cell acanthoma in an infant: an unusual presentation and pitfall in clinical practice.
abstract: BACKGROUND
  Although an umbilical nodule is common in neonates and young infants, an umbilical nodule of poor therapeutic response will increase the likelihood of other uncommon etiology. Clear cell acanthoma (CCA) has never been described as an oozing umbilical nodule on infants.
  
  
  METHODS
  To present a case of CCA which occurred on an 8-month-old female infant presenting with one weeping nodule on the umbilicus since early neonate. The lesion underwent skin biopsy and subsequent hematoxylin-eosin and periodic acid-Schiff staining.
  
  
  RESULTS
  Three courses of liquid nitrogen cryosurgery were performed after the diagnosis of CCA was confirmed. The lesion resolved rapidly.
  
  
  CONCLUSIONS
  This report presents the first and youngest case of umbilical CCA in the English literature. This case supports the inflammatory dermatosic nature of CCA.
authors.affiliation: Department of Dermatology, Chang Gung Memorial Hospital, Taipei, Taiwan.
authors.forename: Hsiu-cheng
authors.initials: HC
authors.lastname: Hsu
authors.forename: Chih-Hsun
authors.initials: CH
authors.lastname: Yang
authors.forename: Tseng-tong
authors.initials: TT
authors.lastname: Kuo
authors.forename: I-Hsin
authors.initials: IH
authors.lastname: Shih
authors.forename: Hong-Shang
authors.initials: HS
authors.lastname: Hong
mesh_terms: D049309:Acanthoma / Q000473:pathology* / Q000628:therapy; D000013:Congenital Abnormalities; D003937:Diagnosis, Differential; D005122:Exudates and Transudates; D005260:Female; D006801:Humans; D007223:Infant; D012878:Skin Neoplasms / Q000473:pathology* / Q000628:therapy; D014472:Umbilicus / Q000002:abnormalities / Q000473:pathology*