Chiari I malformation and idiopathic growth hormone deficiency in siblings: report of three cases.
BACKGROUND
The authors report a case of three brothers.


METHODS
Two of these siblings presented with congenital growth hormone deficiency (GHD) and Chiari I malformation (CIM). The third younger brother has been found not to have GHD or the CIM.


CONCLUSIONS
Sparse cases of these two clinical occurrences have been reported. Further, the posterior cranial fossa (PF) has been determined to be altered in patients with CIM and GHD.


CONCLUSIONS
Our current case reports strengthen the association between these two pathological entities and, to our knowledge, is the first description of both defects in siblings.
Murphy
R Lee
RL
University of Alabama School of Medicine, Birmingham, AL 35233, USA.
Tubbs
R Shane
RS
Grabb
Paul A
PA
Oakes
W Jerry
WJ
D001139:Arnold-Chiari Malformation / Q000503:physiopathology*; D002648:Child; D002675:Child, Preschool; D004677:Encephalocele / Q000209:etiology / Q000473:pathology; D013006:Growth Hormone / Q000627:therapeutic use; D019382:Human Growth Hormone / Q000172:deficiency*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D012249:Rhombencephalon / Q000473:pathology; D012600:Scoliosis / Q000209:etiology; D013595:Syringomyelia / Q000209:etiology
D019382:Human Growth Hormone; D013006:Growth Hormone