title: A simple one-pot multicomponent synthesis of an octahedral nanocontainer molecule.
abstract: A nearly quantitative 18-component synthesis of a nanocontainer, which is built up from six bowl-shaped cavitands that are connected together with 12 -CH=N-CH2CH2-N=CH- linkers, and its subsequent reduction are described. This nanocontainer has an estimated cavity volume of 1,700 A3, large enough to encapsulate several smaller guest molecules or a small-sized biomacromolecule. Potential uses of this nanocontainer and of water-soluble derivatives are in drug delivery, wastewater detoxification, separation technology and as molecular reactor for controlled oligomerizations. Typically, the four-step synthesis of the cavitand building block and the subsequent multicomponent synthesis of the nanocontainer, including its purification, can be accomplished in about 4 weeks.
authors.affiliation: Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, 610 Taylor Road, Piscataway, New Jersey 08854, USA.
authors.forename: Xuejun
authors.initials: X
authors.lastname: Liu
authors.forename: Ralf
authors.initials: R
authors.lastname: Warmuth
mesh_terms: D004988:Ethers, Cyclic / Q000138:chemical synthesis*; D008958:Models, Molecular; D015394:Molecular Structure; D053769:Nanocapsules; D036103:Nanotechnology / Q000379:methods*; D019906:Nuclear Magnetic Resonance, Biomolecular; D012118:Resorcinols / Q000138:chemical synthesis*
chemical_list: D004988:Ethers, Cyclic; D053769:Nanocapsules; D012118:Resorcinols; C442939:cavitand