[Treatment of recurrent condyloma acuminatum with solid lipid nanoparticle gel containing podophyllotoxin: a randomized double-blinded, controlled clinical trial].
OBJECTIVE
To observe the clinical efficacy and safety of podophyllotoxin delivered via solid lipid nanoparticle gel for topic treatment of recurrent condyloma acuminatum.


METHODS
In a randomized double-blinded study, podophyllotoxin solid lipid nanoparticles gel and routine podophyllotoxin gel preparation was applied respectively for treatment of 97 volunteer patients with recurrent condyloma acuminatum. The therapeutic effect, condyloma acuminatum relapse following the treatment and adverse effect were evaluated.


RESULTS
The wart clearance rate in the condyloma acuminatum patients in the first treatment course with podophyllotoxin solid lipid nanoparticle gel reached 97.1%, close to that with the routine preparation of 90.6%, but the nanoparticle preparation significantly reduced the recurrence rate and adverse effect (P<0.01).


CONCLUSIONS
Podophyllotoxin delivered via solid lipid nanoparticle gel can effectively clear condyloma acuminatum and reduce its recurrence rate with only mild, tolerable adverse effect.
Xie
Fang-ming
FM
Department of Dermatology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. Pfk303@163.com
Zeng
Kang
K
Chen
Zhi-liang
ZL
Li
Guo-feng
GF
Lin
Zhong-fang
ZF
Zhu
Xiao-liang
XL
Sun
Le-dong
LD
D000293:Adolescent; D000328:Adult; D003218:Condylomata Acuminata / Q000188:drug therapy* / Q000473:pathology; D004311:Double-Blind Method; D016503:Drug Delivery Systems; D005260:Female; D005782:Gels; D006801:Humans; D008055:Lipids / Q000737:chemistry*; D008297:Male; D008875:Middle Aged; D053758:Nanoparticles / Q000737:chemistry*; D011034:Podophyllotoxin / Q000008:administration & dosage* / Q000737:chemistry; D055502:Secondary Prevention; D016896:Treatment Outcome; D055815:Young Adult
D005782:Gels; D008055:Lipids; D011034:Podophyllotoxin