title: Use of infliximab in pyoderma gangrenosum.
abstract: A 57-year-old man, with a 2-year history of Crohn's disease, presented with a rapidly progressive abdominal ulcer. It was clinically and histologically consistent with pyoderma gangrenosum but it did not respond to either high-dose oral prednisolone or intravenous hydrocortisone. Infliximab resulted in an early, dramatic and sustained improvement. His bowel symptoms, which flared a few weeks prior to the onset of pyoderma gangrenosum, only partially improved. Despite six infliximab infusions, the inflammatory bowel disease is poorly controlled, whereas the pyoderma gangrenosum remains healed.
authors.affiliation: Department of Dermatology, Royal Perth Hospital, Western Australia, Australia. dthewitt@gmail.com
authors.forename: Daniel
authors.initials: D
authors.lastname: Hewitt
authors.forename: Clare
authors.initials: C
authors.lastname: Tait
mesh_terms: D000911:Antibodies, Monoclonal / Q000008:administration & dosage*; D003424:Crohn Disease / Q000150:complications / Q000188:drug therapy*; D003879:Dermatologic Agents / Q000008:administration & dosage*; D006801:Humans; D000069285:Infliximab; D008297:Male; D008875:Middle Aged; D017511:Pyoderma Gangrenosum / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology*; D013256:Steroids / Q000627:therapeutic use; D016896:Treatment Outcome; D014945:Wound Healing
chemical_list: D000911:Antibodies, Monoclonal; D003879:Dermatologic Agents; D013256:Steroids; D000069285:Infliximab