[PK/PD analysis and proper dosage of antimicrobial agents for effective and safe treatment of infectious diseases].
The dosage of antimicrobial agents from PK/PD analysis is now considered important for using these agents effectively and safely. In this paper, I will discuss the proper dosage of antimicrobial agents from the point of PK/PD analysis. I will also discuss the correlation between the safety profile and pharmacokinetic parameters of the agents. It is my hope that all pharmacists will understand the proper use of antimicrobial agents and thus will assure the effective and safe treatment of patients with infectious diseases.
Hori
Seiji
S
Department of Pharmacology (I), Jikei University School of Medicine, Japan. horis@jikei.ac.jp
D000890:Anti-Infective Agents / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics*; D003141:Communicable Diseases / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans
D000890:Anti-Infective Agents