Characterization of tableting using the OSDRC system.
OBJECTIVE
We compared the compression properties and characteristics of tablets obtained using the OSDRC system (method (OSDRC)) and conventional compression methods including multi-layer compression with a pharmaceutical powder.


METHODS
We prepared tablets using four methods of compression. The force profiles, ejection force, stress relaxation, pressure transmission ratio, and internal intensity of the tablets were measured as compression properties.


RESULTS
Method (OSDRC) gave the highest value for the crushing strength of the tablets. Although the compression properties were similar regardless of the method of compression, the internal intensity of tablets compressed by method (OSDRC) was significantly larger than that of the tablets produced by the other methods.


CONCLUSIONS
In terms of crushing strength, the tablets compressed by method (OSDRC) were superior of those obtained by the conventional compression method. Therefore, it is possible to increase the crushing strength of tablets without changing the pharmaceutical formulation.
Shimizu
Kazuyuki
K
Pharmaceutical Research & Technology Laboratory, Sanwa Kagaku Kenkyusho Co., Ltd., 363 Shiosaki Hokusei, Inabe Mie, 511-0406, Japan. ka_shimizu@skk-net.com
Ando
Masaki
M
Nakayama
Yukiharu
Y
D002482:Cellulose / Q000031:analogs & derivatives* / Q000737:chemistry; D019245:Compressive Strength; D007785:Lactose / Q000737:chemistry*; D010615:Phenacetin / Q000737:chemistry*; D016062:Porosity; D011208:Powders; D011312:Pressure; D013229:Stearic Acids / Q000737:chemistry*; D013607:Tablets; D013678:Technology, Pharmaceutical / Q000379:methods*
D011208:Powders; D013229:Stearic Acids; D013607:Tablets; C031183:stearic acid; D002482:Cellulose; C008079:hydroxypropylcellulose; D010615:Phenacetin; D007785:Lactose; C109691:microcrystalline cellulose