title: Prospective non-randomized evaluation of four mediators of the systemic response after extraperitoneal laparoscopic and open retropubic radical prostatectomy.
abstract: OBJECTIVE
  To report a prospective, controlled, non-randomized patient study to determine the systemic response to extraperitoneal laparoscopic (eLRP) and open retropubic radical prostatectomy (RRP).
  
  
  METHODS
  In all, 403 patients who had eLRP (163) or open RRP (240) were recruited; patients in both groups had similar preoperative staging. In addition to peri-operative variables (operative duration, complications, blood loss, transfusion rate, hospitalization, catheterization), oncological data (Gleason score, pathological stage, positive margins) were also compared. The extent of the systemic response to surgery-induced tissue trauma was measured in all patients, by assessing the levels of acute-phase markers C-reactive protein (CRP), serum amyloid A (SAA), interleukin-6 (IL-6) and IL-10 before, during and after RP.
  
  
  RESULTS
  The duration of surgery, transfusion rate, hospital stay and duration of catheterization were comparable with those in previous studies. There was an increase in IL-6, CRP and SAA but no change in IL-10, and no differences between eLRP and RRP over the entire period assessed.
  
  
  CONCLUSIONS
  The invasiveness of eLRP could not be substantiated objectively based on the variables measured in this study. The surgical trauma and associated invasiveness of both methods were equivalent.
authors.affiliation: Department of Urology, Medical Faculty, Martin Luther University, Halle-Wittenberg, Halle/Saale, Germany. andreas.jurczok@medizin.uni-halle.de
authors.forename: Andreas
authors.initials: A
authors.lastname: Jurczok
authors.forename: Mario
authors.initials: M
authors.lastname: Zacharias
authors.forename: Sigrid
authors.initials: S
authors.lastname: Wagner
authors.forename: Amir
authors.initials: A
authors.lastname: Hamza
authors.forename: Paolo
authors.initials: P
authors.lastname: Fornara
mesh_terms: D000328:Adult; D000368:Aged; D002097:C-Reactive Protein / Q000378:metabolism*; D006801:Humans; D007378:Interleukins / Q000378:metabolism*; D010535:Laparoscopy / Q000009:adverse effects / Q000379:methods* / Q000592:standards; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000209:etiology; D011446:Prospective Studies; D011468:Prostatectomy / Q000009:adverse effects / Q000379:methods* / Q000592:standards; D011471:Prostatic Neoplasms / Q000601:surgery*; D011788:Quality of Life; D000685:Serum Amyloid A Protein / Q000378:metabolism*; D016896:Treatment Outcome
chemical_list: D007378:Interleukins; D000685:Serum Amyloid A Protein; D002097:C-Reactive Protein