title: Molecular characterization of post-thrombotic syndrome.
abstract: The post-thrombotic syndrome represents a poorly understood and significant vascular health problem. This review focuses on our current understanding of the pathogenesis of post-thrombotic syndrome. We emphasize the cellular and molecular mechanisms that are responsible for the critical components of post-thrombotic syndrome. These include the initiation of deep venous thrombosis, the pathogenesis of elevated venous pressure, and the factors responsible for nonhealing of venous stasis ulcers.
authors.affiliation: Division of Vascular Surgery and Pacific Vascular Research Laboratories, University of California San Francisco, San Francisco, CA 94121, USA.
authors.forename: Lornie J
authors.initials: LJ
authors.lastname: Phillips
authors.forename: Rajabrata
authors.initials: R
authors.lastname: Sarkar
mesh_terms: D018925:Chemokines / Q000378:metabolism; D016326:Extracellular Matrix Proteins / Q000378:metabolism; D005355:Fibrosis; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism; D020782:Matrix Metalloproteinases / Q000378:metabolism; D011186:Postphlebitic Syndrome / Q000150:complications / Q000209:etiology / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D012307:Risk Factors; D014647:Varicose Ulcer / Q000209:etiology* / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D014690:Venous Pressure; D020246:Venous Thrombosis / Q000150:complications* / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D014945:Wound Healing
chemical_list: D018925:Chemokines; D016326:Extracellular Matrix Proteins; D036341:Intercellular Signaling Peptides and Proteins; D020782:Matrix Metalloproteinases