The use of intraventricular thrombolytics in intraventricular hemorrhage.
Intraventricular hemorrhage (IVH) is associated with a high mortality and morbidity. Patients with this disorder may now be offered the possibility of treatment. This treatment comes in the form of intraventricular thrombolytics. At present a large randomized trial is testing the efficacy of intraventricular rt-PA in IVH in the setting of intracranial hemorrhage (ICH) . Preliminary data suggests that it may be successful in patients with IVH in this setting. This trial is the accumulation of animal and human trials completed over the last 20 years.
Nyquist
Paul
P
Neurology and Anesthesia Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore Maryland, 21287-7840, USA. pnyquis1@jhmi.edu
Hanley
Daniel F
DF
D000818:Animals; D002543:Cerebral Hemorrhage / Q000188:drug therapy*; D002552:Cerebral Ventricles; D002986:Clinical Trials as Topic; D004195:Disease Models, Animal; D006801:Humans; D007276:Injections, Intraventricular; D015912:Thrombolytic Therapy / Q000379:methods