title: Highly enantioselective alkynylation of aldehydes using a new BINOL/Ti(OiPr)4/chiral sulfonamide catalyst system.
abstract: A series of sulfonamides (2-4) were prepared from natural amino acids and used as additives in the BINOL-Ti(OiPr)(4) catalyzed enantioselective alkynylation of aldehydes. The reactions proceeded smoothly with good yields and very high ee's (up to 99%) in most cases.
authors.affiliation: School of Pharmaceutical Science, Zhongshan University, Guangzhou, People's Republic of China. xsli219@yahoo.com
authors.forename: Xingshu
authors.initials: X
authors.lastname: Li
authors.forename: Gui
authors.initials: G
authors.lastname: Lu
authors.forename: Xian
authors.initials: X
authors.lastname: Jia
authors.forename: Yinuo
authors.initials: Y
authors.lastname: Wu
authors.forename: Albert S C
authors.initials: AS
authors.lastname: Chan
mesh_terms: D000447:Aldehydes / Q000138:chemical synthesis* / Q000737:chemistry*; D000480:Alkynes / Q000138:chemical synthesis / Q000737:chemistry; D002384:Catalysis; D007202:Indicators and Reagents; D015394:Molecular Structure; D009284:Naphthols; D009942:Organometallic Compounds; D013237:Stereoisomerism; D014025:Titanium
chemical_list: D000447:Aldehydes; D000480:Alkynes; C406944:BINOL, naphthol; D007202:Indicators and Reagents; D009284:Naphthols; D009942:Organometallic Compounds; C102815:titanium isopropoxide; D014025:Titanium