title: The IRF5 polymorphism in type 1 diabetes.
abstract: The interferon regulatory factor 5 gene (IRF5) has been shown to play a crucial role in harmful immune responses by induction of proinflammatory cytokines. Functional genetic variants associated with increased IRF5 expression of specific isoforms are associated with systemic lupus erythematosus (SLE) and it is possible that they may also predispose to other autoimmune disorders. We tested the association of two IRF5 SNPs, correlated with IRF5 expression and SLE risk, in 947 nuclear family trios type 1 diabetes (T1D) using the transmission disequilibrium test. Our results suggest that the functional IRF5 variations do not confer an obvious risk for T1D.
authors.forename: Hui-Qi
authors.initials: HQ
authors.lastname: Qu
authors.forename: Luc
authors.initials: L
authors.lastname: Marchand
authors.forename: Rosemary
authors.initials: R
authors.lastname: Grabs
authors.forename: Constantin
authors.initials: C
authors.lastname: Polychronakos
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D016207:Cytokines / Q000378:metabolism; D003920:Diabetes Mellitus / Q000235:genetics*; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics*; D014644:Genetic Variation; D006801:Humans; D007107:Immune System; D007249:Inflammation; D050835:Interferon Regulatory Factors / Q000235:genetics*; D015810:Linkage Disequilibrium; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D051193:Toll-Like Receptors / Q000378:metabolism
chemical_list: D016207:Cytokines; C431713:IRF5 protein, human; D050835:Interferon Regulatory Factors; D051193:Toll-Like Receptors