title: Tumor-associated macrophages press the angiogenic switch in breast cancer.
abstract: The development of a supportive vasculature is essential for tumor progression. In a mouse model of breast cancer, we found that tumor-associated macrophages that are recruited to the tumor just before malignant conversion are essential for the angiogenic switch. These findings establish a causal linkage to explain well-documented clinical correlations between macrophages, microvessel density, and poor prognosis in breast tumors.
authors.affiliation: Department of Developmental and Molecular Biology, Center of Reproductive Biology and Women's Health, Albert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA.
authors.forename: Elaine Y
authors.initials: EY
authors.lastname: Lin
authors.forename: Jeffrey W
authors.initials: JW
authors.lastname: Pollard
mesh_terms: D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000276:immunology / Q000473:pathology*; D004195:Disease Models, Animal; D008264:Macrophages / Q000276:immunology / Q000473:pathology*; D008325:Mammary Neoplasms, Experimental / Q000098:blood supply* / Q000276:immunology / Q000473:pathology; D051379:Mice; D008822:Mice, Transgenic; D009389:Neovascularization, Pathologic / Q000276:immunology / Q000473:pathology