[The expression and role of glucose transporter-1 in infantile hemangioma].
OBJECTIVE
To investigate the expression and role of glucose transporter-1 (Glut1) in infantile hemangioma.


METHODS
Fifty-two samples from infantile hemangioma, 25 in cavernous venous malformation, 9 in arteriovenous malformation, 2 in capillary malformation and 5 in normal skin samples were involved in this study. The EnVision immunohistochemical stain was used to investigate the expression of Glut1 protein in these samples.


RESULTS
In the early proliferating stage, a number of endothelial cells expressed Glut1. In the middle proliferating stage, most of vascular endothelial cells and scattered endothelial cells expressed Glut1. In the late proliferating stage, the expression of Glut1 decreased quickly. In the involuting stage, all hemangioma samples didn't express Glut1. All of the samples from the cavernous venous malformations, arteriovenous malformations, capillary malformations and normal skin had no expression of Glut1.


CONCLUSIONS
Glut1 may be one of the phenotypes of infantile hemangioma endothelial cells in their development, rather than the inherent character. The expression of Glut1 changes according to the metabolic need of infantile hemangioma cells.
Yuan
Si-Ming
SM
Department of Burn and Plastic Surgery, Plastic Surgery, Nanjing General Hospital of Nanjing Command, Nanjing 210002, China.
Jiang
Hui-Qing
HQ
Hong
Zhi-Jian
ZJ
Wang
Jun
J
Hu
Xin-Bao
XB
Ouyang
Tian-Xiang
TX
Xing
Xin
X
D001808:Blood Vessels; D002648:Child; D002675:Child, Preschool; D004730:Endothelium, Vascular / Q000378:metabolism; D051272:Glucose Transporter Type 1 / Q000378:metabolism*; D006391:Hemangioma / Q000378:metabolism*; D006801:Humans; D007223:Infant; D010641:Phenotype; D054079:Vascular Malformations / Q000378:metabolism* / Q000473:pathology*
D051272:Glucose Transporter Type 1; C495677:SLC2A1 protein, human