[Current gene study in etiological analysis of congenital craniofacial abnormalities].
The cause of congenital craniofacial abnormalities are very complicated. Understanding of the gene mechanisms of abnormalities taking place are very important for prevention and therapy.DNA sequence analysis provides the fundaments of gene study of the congenital craniofacial abnormalities. Human genome project (HGP) paved the confirmation of candidate gene of the congenital craniofacial abnormalities.Transgenic animal models and gene knockout techniques are effective methods in study of gene function. This paper reviews current gene study in etiopathogenisis analysis of the congenital craniofacial abnormalities.
Feng
Yi-miao
YM
Department of Oral Maxillofacial Surgery, College of Stomatology, Ninth People's Hospital,School of Medicine, Shanghai Jiao Tong University, Shanghai 200011, China. braces_dr@hotmail.com
Fang
Bing
B
D019465:Craniofacial Abnormalities / Q000235:genetics*; D016045:Human Genome Project; D006801:Humans; D017422:Sequence Analysis, DNA