title: AHSG gene polymorphisms are associated with bone mineral density in Caucasian nuclear families.
abstract: OBJECTIVE
  To investigate the role of alpha2-HS glycoprotein (AHSG) gene on bone mineral density (BMD) variation.
  
  
  METHODS
  A total of 665 subjects from 157 Caucasian nuclear families were genotyped at the AHSG NlaIII, SacI sites. The association and linkage between the single SNP markers and haplotypes constructed by two markers in this gene and BMDs at the spine and hip were determined by using quantitative transmission disequilibrium test (QTDT).
  
  
  RESULTS
  Significant within-family associations were obtained for spine BMD at both of studied markers (P = 0.036 and 0.005 at the NlaIII and SacI sites, respectively). Significant (P = 0.008 at the NlaIII locus) (P = 0.004 at the SacI locus) total associations at spine BMD were detected. Haplotype analyses confirmed those within-family and total association.
  
  
  CONCLUSIONS
  These data suggest the polymorphisms in the AHSG gene may have effects on BMD variation in Caucasian population.
authors.affiliation: Laboratory of Molecular and Statistical Genetics and the Key Laboratory of Protein Chemistry and Developmental Biology of the Ministry of Education, College of Life Sciences, Hunan Normal University, Changsha, Hunan, 410081, PR China.
authors.forename: Yan-Jun
authors.initials: YJ
authors.lastname: Yang
authors.forename: Yan-Bo
authors.initials: YB
authors.lastname: Wang
authors.forename: Shu-Feng
authors.initials: SF
authors.lastname: Lei
authors.forename: Ji-Rong
authors.initials: JR
authors.lastname: Long
authors.forename: Hui
authors.initials: H
authors.lastname: Shen
authors.forename: Lan-Juan
authors.initials: LJ
authors.lastname: Zhao
authors.forename: De-Ke
authors.initials: DK
authors.lastname: Jiang
authors.forename: Su-Mei
authors.initials: SM
authors.lastname: Xiao
authors.forename: Xiang-Ding
authors.initials: XD
authors.lastname: Chen
authors.forename: Yuan
authors.initials: Y
authors.lastname: Chen
authors.forename: Hong-Wen
authors.initials: HW
authors.lastname: Deng
mesh_terms: D000328:Adult; D001798:Blood Proteins / Q000235:genetics*; D015519:Bone Density / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D008040:Genetic Linkage; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D009329:Nebraska; D009679:Nuclear Family; D010024:Osteoporosis / Q000235:genetics*; D011110:Polymorphism, Genetic; D044465:White People / Q000235:genetics*; D060749:alpha-2-HS-Glycoprotein
chemical_list: C556354:AHSG protein, human; D001798:Blood Proteins; D060749:alpha-2-HS-Glycoprotein