title: [Clinical analysis of infectious complications following abdominal cluster transplantation].
abstract: OBJECTIVE
  To investigate the characteristic and management of postoperative infection in abdominal cluster transplantation.
  
  
  METHODS
  Preliminary experience of two cases of abdominal cluster transplantation including small intestine was reviewed.
  
  
  RESULTS
  Combination of five immunosuppressive agents based on tacrolimus was used. Severe Gram-negative bacillus infections occurred. The majority of invasive fungal infections was due to Candida species. Cytomegalovirus (CMV) infection increased monocytes and caused eosinopenia and an inversion of the CD4(+) to CD8(+) cell ratio in recipient I, and human CMV matrix proteins pp71 (CMV-pp71) was detected and identified in bile by PCR. Microabscesses in liver transplant biopsies were presented.
  
  
  CONCLUSIONS
  Infectious complications after cluster transplantation were complicated. Strategies to optimize the immunity suppression protocol and early diagnosis and treatment will be important to reduce infection after abdominal cluster transplantation.
authors.affiliation: Department of General Surgery, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
authors.forename: Hui-xing
authors.initials: HX
authors.lastname: Chen
authors.forename: Lu
authors.initials: L
authors.lastname: Yin
authors.forename: Cheng-hong
authors.initials: CH
authors.lastname: Peng
authors.forename: Guang-wen
authors.initials: GW
authors.lastname: Zhou
authors.forename: Bai-yong
authors.initials: BY
authors.lastname: Shen
authors.forename: Gui-ming
authors.initials: GM
authors.lastname: Chen
authors.forename: Chun-qiu
authors.initials: CQ
authors.lastname: Chen
authors.forename: Hui-jiang
authors.initials: HJ
authors.lastname: Zhou
authors.forename: Hong-wei
authors.initials: HW
authors.lastname: Li
mesh_terms: D000328:Adult; D001424:Bacterial Infections / Q000188:drug therapy / Q000209:etiology; D003586:Cytomegalovirus Infections / Q000188:drug therapy / Q000209:etiology / Q000821:virology; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use; D007421:Intestine, Small / Q000637:transplantation*; D016031:Liver Transplantation / Q000009:adverse effects / Q000379:methods; D008297:Male; D009894:Opportunistic Infections / Q000188:drug therapy / Q000209:etiology*; D016377:Organ Transplantation / Q000009:adverse effects* / Q000379:methods; D011183:Postoperative Complications / Q000188:drug therapy / Q000209:etiology*; D012189:Retrospective Studies
chemical_list: D007166:Immunosuppressive Agents