The association of RANTES polymorphism with severe acute respiratory syndrome in Hong Kong and Beijing Chinese.
BACKGROUND
Chemokines play important roles in inflammation and antiviral action. We examined whether polymorphisms of RANTES, IP-10 and Mig affect the susceptibility to and outcome of severe acute respiratory syndrome (SARS).


METHODS
We tested the polymorphisms of RANTES, IP-10 and Mig for their associations with SARS in 495 Hong Kong Chinese SARS patients and 578 controls. Then we tried to confirm the results in 356 Beijing Chinese SARS patients and 367 controls.


RESULTS
RANTES -28 G allele was associated with SARS susceptibility in Hong Kong Chinese (P < 0.0001, OR = 2.80, 95%CI:2.11-3.71). Individuals with RANTES -28 CG and GG genotypes had a 3.28-fold (95%CI:2.32-4.64) and 3.06-fold (95%CI:1.47-6.39) increased risk of developing SARS respectively (P < 0.0001). This -28 G allele conferred risk of death in a gene-dosage dependent manner (P = 0.014) with CG and GG individuals having a 2.12-fold (95% CI: 1.11-4.06) and 4.01-fold (95% CI: 1.30-12.4) increased risk. For the replication of RANTES data in Beijing Chinese, the -28 G allele was not associated with susceptibility to SARS. However, -28 CG (OR = 4.27, 95%CI:1.64-11.1) and GG (OR = 3.34, 95%CI:0.37-30.7) were associated with admission to intensive care units or death due to SARS (P = 0.011).


CONCLUSIONS
RANTES -28 G allele plays a role in the pathogenesis of SARS.
Ng
Man Wai
MW
Department of Paediatrics and Adolescent Medicine, The Hong Kong Jockey Club Research Centre, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China. ivy_natsu@yahoo.com.hk <ivy_natsu@yahoo.com.hk>
Zhou
Gangqiao
G
Chong
Wai Po
WP
Lee
Loretta Wing Yan
LW
Law
Helen Ka Wai
HK
Zhang
Hongxing
H
Wong
Wilfred Hing Sang
WH
Fok
Susanna Fung Shan
SF
Zhai
Yun
Y
Yung
Raymond W H
RW
Chow
Eudora Y
EY
Au
Ka Leung
KL
Chan
Eric Y T
EY
Lim
Wilina
W
Peiris
J S  Malik
JS
He
Fuchu
F
Lau
Yu Lung
YL
D000328:Adult; D017677:Age Distribution; D016022:Case-Control Studies; D018946:Chemokine CCL5 / Q000235:genetics*; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D016001:Confidence Intervals; D005260:Female; D005500:Follow-Up Studies; D015967:Gene Expression Regulation, Viral; D020022:Genetic Predisposition to Disease / Q000453:epidemiology*; D006723:Hong Kong / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D011336:Probability; D018570:Risk Assessment; D045473:Severe acute respiratory syndrome-related coronavirus / Q000235:genetics* / Q000302:isolation & purification; D045169:Severe Acute Respiratory Syndrome / Q000453:epidemiology* / Q000235:genetics*; D017678:Sex Distribution
D018946:Chemokine CCL5