Host genetic resistance to symptomatic norovirus (GGII.4) infections in Denmark.
A total of 61 individuals involved in five norovirus outbreaks in Denmark were genotyped at nucleotides 428 and 571 of the FUT2 gene, determining secretor status, i.e., the presence of ABH antigens in secretions and on mucosa. A strong correlation (P = 0.003) was found between the secretor phenotype and symptomatic disease, extending previous knowledge and confirming that nonsense mutations in the FUT2 gene provide protection against symptomatic norovirus (GGII.4) infections.
Kindberg
Elin
E
Division of Molecular Virology, Medical Faculty, University of Linköping, Linköping, Sweden.
Akerlind
Britt
B
Johnsen
Christina
C
Knudsen
Jenny Dahl
JD
Heltberg
Ole
O
Larson
Göran
G
Böttiger
Blenda
B
Svensson
Lennart
L
D017250:Caliciviridae Infections / Q000453:epidemiology / Q000235:genetics* / Q000821:virology; D018389:Codon, Nonsense; D003718:Denmark; D004196:Disease Outbreaks; D005647:Fucosyltransferases / Q000235:genetics*; D005838:Genotype; D006801:Humans; D007113:Immunity, Innate / Q000235:genetics*; D000097631:Galactoside 2-alpha-L-fucosyltransferase
D018389:Codon, Nonsense; D005647:Fucosyltransferases; D000097631:Galactoside 2-alpha-L-fucosyltransferase