title: Fibromyalgia syndrome.
abstract: The fibromyalgia syndrome (FM) workshop at OMERACT 8 continued the work initiated in the first FM workshop at OMERACT 7 in 2004. The principal objectives were to work toward consensus on core domains for assessment in FM studies, evaluate the performance quality of outcome measures used in a review of recent trials in FM, and discuss the research agenda of the FM working group. An initiative to include the patient perspective on identification and prioritization of domains, consisting of focus groups and a patient Delphi exercise, was completed prior to OMERACT 8. Patient-identified domains were, for the most part, similar to those identified by clinician-investigators in terms of symptoms and relative importance. However, patients identified certain domains, such as stiffness, that were not included by physicians, and emphasized the importance of domains such as dyscognition and impaired motivation. Many of the principal domains agreed upon by the clinician-investigators, patients, and OMERACT participants, including pain, fatigue, sleep, mood, and global measures, have been used in clinical trials and performed well when viewed through the OMERACT filter. The research agenda items reviewed and approved for continued study included development of objective "biomarkers" in FM, development of a responder index for FM, and coordination with the WHO's International Classification of Functioning Disability and Health (ICF) Research Branch and the US National Institutes of Health's Patient Reported Outcome Measures Information System network (PROMIS) to develop improved measures of function, quality of life, and participation. The OMERACT process has provided a framework for identification of key domains to be assessed and a path toward validation and standardization of outcome measures for clinical trials in FM.
authors.affiliation: Seattle Rhumatology Associates, Seattle, WA 98104, USA. pmease@nwlink.com
authors.forename: Philip
authors.initials: P
authors.lastname: Mease
authors.forename: Lesley M
authors.initials: LM
authors.lastname: Arnold
authors.forename: Robert
authors.initials: R
authors.lastname: Bennett
authors.forename: Annelies
authors.initials: A
authors.lastname: Boonen
authors.forename: Dan
authors.initials: D
authors.lastname: Buskila
authors.forename: Serena
authors.initials: S
authors.lastname: Carville
authors.forename: Amy
authors.initials: A
authors.lastname: Chappell
authors.forename: Ernest
authors.initials: E
authors.lastname: Choy
authors.forename: Daniel
authors.initials: D
authors.lastname: Clauw
authors.forename: Dina
authors.initials: D
authors.lastname: Dadabhoy
authors.forename: Michael
authors.initials: M
authors.lastname: Gendreau
authors.forename: Don
authors.initials: D
authors.lastname: Goldenberg
authors.forename: Geoffrey
authors.initials: G
authors.lastname: Littlejohn
authors.forename: Susan
authors.initials: S
authors.lastname: Martin
authors.forename: Philip
authors.initials: P
authors.lastname: Perera
authors.forename: I Jon
authors.initials: IJ
authors.lastname: Russell
authors.forename: Lee
authors.initials: L
authors.lastname: Simon
authors.forename: Michael
authors.initials: M
authors.lastname: Spaeth
authors.forename: David
authors.initials: D
authors.lastname: Williams
authors.forename: Leslie
authors.initials: L
authors.lastname: Crofford
mesh_terms: D004185:Disability Evaluation; D005356:Fibromyalgia / Q000145:classification* / Q000503:physiopathology / Q000628:therapy; D017144:Focus Groups; D006305:Health Status Indicators; D006801:Humans; D007391:International Cooperation; D017063:Outcome Assessment, Health Care; D010358:Patient Participation; D011785:Quality Assurance, Health Care; D015203:Reproducibility of Results