Synthesis, spectral studies and antibacterial activity of novel macrocyclic Co(II) compounds.
Ten novel macrocyclic Co(II) compounds have been synthesized by treating four N(4) and six N(2)O(2) donor macrocycles with cobalt chloride in methanol. These compounds were characterized by elemental, IR, (1)H, (13)C NMR, mass, electronic spectral analysis, molar conductance and magnetic susceptibility measurements. Thermal behavior of these compounds has been studied by the thermogravimetric analysis. An octahedral geometry has been proposed for all of these complexes. All the macrocycles and macrocyclic Co(II) compounds along with existing antibacterial drugs were screened for antibacterial activity against Gram +ve and Gram -ve bacteria. All these compounds were found to be more active when compared to streptomycin and ampicillin.
Reddy
P Muralidhar
PM
Department of Chemistry, Kakatiya University, Warangal, India.
Prasad
Adapa V S S
AV
Shanker
Kanne
K
Ravinder
Vadde
V
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D002247:Carbon Isotopes; D004553:Electric Conductivity; D004583:Electrons; D047028:Macrocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008280:Magnetics; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D013055:Spectrophotometry, Infrared; D013696:Temperature
D000900:Anti-Bacterial Agents; D002247:Carbon Isotopes; D047028:Macrocyclic Compounds