Attributable mortality of Acinetobacter baumannii: no longer a controversial issue.
There has been controversy regarding the mortality directly attributed to Acinetobacter baumannii infections. Data from six case-control studies have been recently added to the literature regarding the attributable mortality of A. baumannii infections during the past months. The information from these studies, added to the previous knowledge on this issue, provides evidence that A. baumannii infections are indeed associated with increased mortality. In addition, there is relevant evidence from studies examining the effect of inappropriate treatment on mortality; specifically, inappropriate treatment of A. baumannii infections has been associated with excess mortality. We believe that the accumulated data suggest that attributable mortality due to A. baumannii infections should no longer be a controversial issue. The efforts of the scientific community interested in this pathogen should therefore be directed to the development and introduction of new antibiotics effective against multidrug-resistant and pandrug-resistant A. baumannii as well as the implementation of infection control measures that may help us in the control of the increasing problem of A. baumannii infections.
Falagas
Matthew E
ME
Alfa Institute of Biomedical Sciences, Athens, Greece. m.falagas@aibs.gr
Rafailidis
Petros I
PI
D000151:Acinetobacter Infections / Q000188:drug therapy / Q000401:mortality*; D040981:Acinetobacter baumannii; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001315:Australia / Q000453:epidemiology; D016022:Case-Control Studies; D002423:Cause of Death; D024901:Drug Resistance, Multiple, Bacterial / Q000187:drug effects; D006801:Humans; D007557:Israel / Q000453:epidemiology; D007723:Korea / Q000453:epidemiology; D014481:United States / Q000453:epidemiology
D000900:Anti-Bacterial Agents