Cytotoxic activity of the selected pyridinium salts against murine leukemia L1210.
The objective of this work was to evaluate the relationship between chemical reactivity of 3-substituted pyridinium salts and their cytotoxic properties against murine leukemia L1210. Chemical reactivity of pyridinium salts towards NADH oxidation following one-step hydride transfer depends strongly on their redox properties. The investigated reaction may reflect the ability of the salts to deplete NADH level in cells and to affect their metabolic functions. On the other hand, the cytotoxic activity against murine leukemia cells, expressed as ED50 values, varied strongly depending upon the compound used. The investigated salts showed also a diverse antileukemic effect in in vivo experiments as measured by the increase in the survival time of L1210 leukemia-bearing mice. These biological effects were correlated with equilibrium constants found for the reaction of pyridinium salts with NADH.
Wieczorkowska
Marzena
M
Institute of Applied Radiation Chemistry, Technical University of Łódź, Zeromskiego 116, PL 90-924 Łódź, Poland.
Szajerski
Piotr
P
Michalski
Radosław
R
Adamus
Jan
J
Marciniak
Andrzej
A
Gebicki
Jerzy
J
Ciesielska
Ewa
E
Szmigiero
Leszek
L
Lech-Marańda
Ewa
E
Szmigielska-Kapłon
Anna
A
Robak
Tadeusz
T
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D006863:Hydrogen-Ion Concentration; D007939:Leukemia L1210 / Q000188:drug therapy* / Q000473:pathology; D051379:Mice; D009243:NAD / Q000737:chemistry; D010084:Oxidation-Reduction; D011725:Pyridines / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D011725:Pyridines; D009243:NAD