Effectiveness of intravenous administration of nicorandil in a patient with variant angina refractory to continuous intravenous nitroglycerin.
Variant angina usually responds to conventional treatment with nitrates and calcium antagonists. However, severe variant angina refractory to intensive anti-anginal treatment can be catastrophic because prolonged occlusion of a major coronary artery can result in myocardial infarction, severe cardiac arrhythmia, and sudden death. We report a patient with active variant angina which was refractory to conventional treatment including sublingual nitroglycerin and intravenous nitroglycerin administration. Only intravenous administration of nicorandil was consistently effective in eliminating chest pain of the patient.
Lee
Kyung-Hun
KH
Kim
Seong Hwan
SH
Lim
Hong Euy
HE
Kim
Eung Ju
EJ
Kim
Min-Kyu
MK
Park
Woo-Jung
WJ
Cho
Goo-Yeong
GY
D000368:Aged; D000788:Angina Pectoris, Variant / Q000188:drug therapy*; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage*; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D020108:Nicorandil / Q000008:administration & dosage*; D005996:Nitroglycerin / Q000008:administration & dosage; D016896:Treatment Outcome
D000889:Anti-Arrhythmia Agents; D020108:Nicorandil; D005996:Nitroglycerin