title: Tying SUMO modifications to dynamic behaviors of chromosomes during meiotic prophase of Saccharomyces cerevisiae.
abstract: In budding yeast Saccharomyces cerevisiae, centromeres and telomeres are tethered to the nuclear envelope during premeiotic interphase. Immediately after cells enter meiotic prophase, chromosomes undergo global reorganization, including bouquet formation (telomere clustering), non-homologous centromere coupling, homologous pairing, and assembly/disassembly of synaptonemal complexes. These chromosome dynamics have been implicated in promoting pairing, synapsis, crossover DNA recombination and segregation between homologous chromosomes. This review discusses recent studies related to the role of small ubiquitin-like modifier (SUMO) modification in controlling the overall budding yeast chromosome dynamics during meiotic prophase.
authors.affiliation: Institute of Biological Chemistry, Academia Sinica, Taipei, 115, Taiwan.
authors.forename: Chun-Hsu
authors.initials: CH
authors.lastname: Cheng
authors.forename: Feng-Ming
authors.initials: FM
authors.lastname: Lin
authors.forename: Yu-Hui
authors.initials: YH
authors.lastname: Lo
authors.forename: Ting-Fang
authors.initials: TF
authors.lastname: Wang
mesh_terms: D001665:Binding Sites; D015825:Chromosomes, Fungal / Q000502:physiology*; D008540:Meiosis; D008954:Models, Biological; D009687:Nuclear Proteins; D011418:Prophase; D012097:Repressor Proteins / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000235:genetics* / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism; D025841:Small Ubiquitin-Related Modifier Proteins / Q000378:metabolism*; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism
chemical_list: D009687:Nuclear Proteins; D012097:Repressor Proteins; C099362:SMT3 protein, S cerevisiae; D029701:Saccharomyces cerevisiae Proteins; D025841:Small Ubiquitin-Related Modifier Proteins; C090118:Zip1 protein, S cerevisiae; D044767:Ubiquitin-Protein Ligases; C523917:Zip3 protein, S cerevisiae