title: A prospective study of rotavirus diarrhea in children under 1 year of age.
abstract: The aim of this study was to document the changing clinical profile and prognosis of acute diarrhea in infants. This was a prospective observational study with follow-up. Demographic, anthropometric, and clinical data were collected in children younger than 1 year with acute diarrhea. Stool was examined under the microscope, cultured, tested for presence of reducing substance and occult blood, and subjected to electrophoresis to detect rotavirus infection. Thirty-one (91.2%) of the 34 infants were breastfed, 18 exclusively and 13 partially. Twenty-three had rotavirus infection and had slower nutritional recovery than others. There was no difference in the incidence of rotavirus infection between exclusively and partially breastfed infants. Continuation of feeds containing lactose did not affect prognosis, though 23 (67.6%) infants had reducing substance in stool. We documented a high incidence of rotavirus infection, which negatively affected growth of infants by some ill-defined mechanism. Failure of exclusive breastfeeding to protect against rotavirus infection highlights the need for universal rotavirus vaccination. Lactose malabsorption detected in many infants did not affect prognosis after acute diarrhea.
authors.affiliation: Department of Pediatrics, UIC College of Medicine at Peoria, Peoria, Illinois 61603, USA. smisra@uic.edu
authors.forename: Sudipta
authors.initials: S
authors.lastname: Misra
authors.forename: Tapas K
authors.initials: TK
authors.lastname: Sabui
authors.forename: Swati
authors.initials: S
authors.lastname: Basu
authors.forename: Nishith
authors.initials: N
authors.lastname: Pal
mesh_terms: D001942:Breast Feeding; D003968:Diarrhea, Infantile / Q000453:epidemiology* / Q000821:virology*; D004591:Electrophoresis, Polyacrylamide Gel; D005243:Feces / Q000821:virology; D005260:Female; D006801:Humans; D015994:Incidence; D007194:India / Q000453:epidemiology; D007223:Infant; D007787:Lactose Intolerance / Q000453:epidemiology; D008297:Male; D011446:Prospective Studies; D012400:Rotavirus Infections / Q000453:epidemiology*