Anaphylaxis to leuprolide acetate depot injection during treatment for prostate cancer.
A 66-year-old man with clinically localized prostate cancer had elected brachytherapy as the primary management of his disease. During induction of neoadjuvant androgen deprivation for purposes of cytoreduction, the patient experienced anaphylaxis immediately after his first injection of a leuprolide acetate depot. He required emergent intubation and extended hospitalization. Anaphylactic reactions to leuprolide acetate depots have been described as exceedingly rare. To our knowledge, we report the first case of an anaphylactic reaction to a leuprolide acetate depot injection in an American man undergoing treatment for prostate cancer.
Grant
John P
JP
Department of Urology, St Luke's-Roosevelt Medical Center, Baltimore, MD, USA.
Levinson
Adam W
AW
D000368:Aged; D000707:Anaphylaxis / Q000175:diagnosis / Q000276:immunology*; D018931:Antineoplastic Agents, Hormonal / Q000008:administration & dosage / Q000009:adverse effects* / Q000276:immunology; D001918:Brachytherapy; D006801:Humans; D007267:Injections; D016729:Leuprolide / Q000008:administration & dosage / Q000009:adverse effects* / Q000276:immunology; D008297:Male; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy
D018931:Antineoplastic Agents, Hormonal; C493311:luprolide acetate gel depot; D016729:Leuprolide