Serotonin delays habituation of leech swim response to touch.
Serotonin, acting through a cAMP-signaling pathway, delayed habituation to criterion of the leech's swim response to touch. This delay was reversed by crushing the connective between serotonin-exposed and serotonin-naive ganglia, and correlated with an increase in spontaneous impulse activity in this connective. We suggest that increased activity in intersegmental interneurons may play a role in maintaining swim responsiveness when concentrations of serotonin are elevated.
Alkatout
Bilal A
BA
Biology Department and Neuroscience Program, Saint Olaf College, 1520 St. Olaf Ave., Northfield, MN 55057, USA.
Marvin
Nicole M
NM
Crisp
Kevin M
KM
D000200:Action Potentials / Q000187:drug effects; D000704:Analysis of Variance; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology; D000242:Cyclic AMP / Q000031:analogs & derivatives / Q000494:pharmacology; D004347:Drug Interactions / Q000528:radiation effects; D017952:Ganglia, Invertebrate / Q000166:cytology; D006185:Habituation, Psychophysiologic / Q000187:drug effects*; D007097:Imines / Q000494:pharmacology; D066298:In Vitro Techniques; D007395:Interneurons / Q000187:drug effects; D007865:Leeches / Q000502:physiology*; D008124:Locomotion / Q000187:drug effects*; D047428:Protein Kinase Inhibitors / Q000494:pharmacology; D012701:Serotonin / Q000494:pharmacology*; D013550:Swimming; D013873:Thionucleotides / Q000494:pharmacology; D014110:Touch
D007097:Imines; D047428:Protein Kinase Inhibitors; D013873:Thionucleotides; C016957:adenosine-3',5'-cyclic phosphorothioate; D012701:Serotonin; C014925:RMI 12330A; D000242:Cyclic AMP