Clinical predictors of response to cognitive-behavioral therapy for obsessive-compulsive disorder.
This paper reviews predictors of treatment response in open and controlled trials of cognitive-behavioral therapy for obsessive-compulsive disorder (OCD). We focus on demographic characteristics, aspects of OCD symptoms, comorbidity, family factors, cognitive influences, and treatment-specific characteristics as predictor variables. Although inconsistent findings characterize much of the literature, several relatively consistent and salient predictors have emerged, including symptom severity, symptom subtype, severe depression, the presence of comorbid personality disorders, family dysfunction, and the therapeutic alliance. Implications of findings and recommendations for future research are discussed.
Keeley
Mary L
ML
Department of Clinical & Health Psychology, University of Florida, Gainesville, Florida, United States; Department of Psychiatry, University of Florida, Gainesville, Florida, United States.
Storch
Eric A
EA
Department of Psychiatry, University of Florida, Gainesville, Florida, United States; Department of Pediatrics, University of Florida, Gainesville, FL, United States. Electronic address: estorch@psychiatry.ufl.edu.
Merlo
Lisa J
LJ
Department of Psychiatry, University of Florida, Gainesville, Florida, United States.
Geffken
Gary R
GR
Department of Psychiatry, University of Florida, Gainesville, Florida, United States; Department of Pediatrics, University of Florida, Gainesville, FL, United States.
D000328:Adult; D002986:Clinical Trials as Topic / Q000706:statistics & numerical data; D015928:Cognitive Behavioral Therapy / Q000379:methods*; D015897:Comorbidity; D005260:Female; D006801:Humans; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy*; D010554:Personality Disorders / Q000175:diagnosis / Q000453:epidemiology; D011379:Prognosis; D012720:Severity of Illness Index; D016896:Treatment Outcome