Myocardial protection in man--from research concept to clinical practice.
Myocardial protection aims at preventing myocardial tissue loss: (a) In the acute stage, i.e., during primary angioplasty in acute myocardial infarction. In this setup, the attenuation of reperfusion injury is the main target. As a "mechanical" means, post-conditioning has already been tried in man with encouraging results. Pharmacologic interventions that could be of promise are statins, insulin, peptide hormones, including erythropoietin, fibroblast growth factor, and many others. (b) The patient with chronic coronary artery disease offers another paradigm, with the target of avoidance of further myocyte loss through apoptosis and inflammation. Various pharmacologic agents may prove useful in this context, together with exercise and "mechanical" improvement of cardiac function with attenuation of myocardial stretch, which by itself is a noxious influence. A continuous effort toward acute and chronically preserving myocardial integrity is a concept concerning both the researcher and the clinician.
Cokkinos
Dennis V
DV
1st Cardiology Department, Onassis Cardiac Surgery Center, Athens, Greece. cokkino1@otenet.gr
Pantos
Costas
C
D000208:Acute Disease; D035843:Biomedical Research; D002316:Cardiotonic Agents; D019317:Evidence-Based Medicine; D006801:Humans; D019157:Ischemic Preconditioning, Myocardial; D009203:Myocardial Infarction / Q000150:complications; D017202:Myocardial Ischemia / Q000503:physiopathology / Q000517:prevention & control*; D015425:Myocardial Reperfusion; D015428:Myocardial Reperfusion Injury; D009206:Myocardium / Q000473:pathology*; D013959:Thyroid Diseases
D002316:Cardiotonic Agents