Resurgence of cardiac t-tubule research.
The transverse tubules of mammalian cardiac ventricular myocytes are invaginations of the surface membrane. Recent data have revealed that their structure and function are more complex than previously believed. Here, we review current knowledge about their role in cardiac function, focusing on Ca2+ signaling and changes observed in pathological conditions.
Brette
Fabien
F
Faculty of Life Sciences, University of Manchester, Manchester, United kingdom. f.brette@manchester.ac.uk
Orchard
Clive
C
D000818:Animals; D020013:Calcium Signaling / Q000502:physiology*; D006801:Humans; D009200:Myocardial Contraction / Q000502:physiology*; D032383:Myocytes, Cardiac / Q000502:physiology* / Q000648:ultrastructure; D012508:Sarcolemma / Q000502:physiology*; D012519:Sarcoplasmic Reticulum / Q000502:physiology*