Inhibition of alpha-glucosidase and amylase by bartogenic acid isolated from Barringtonia racemosa Roxb. seeds.
Barringtonia racemosa presents a wide range of therapeutic applications. In the course of identifying bioactives from Indian medicinal plants it was observed that the hexane, ethanol and methanol extracts of B. racemosa seeds displayed potent yeast and intestinal alpha-glucosidase inhibitory activities. The methanol extract was found to be superior among them. However, none of the extracts exhibited pancreatic alpha-amylase inhibitory activity, rather the ethanol and methanol extracts accelerated the alpha-amylase enzyme activity. Interestingly, however, bartogenic acid isolated from the methanol extract inhibited alpha-amylase also. This is the first report identifying alpha-glucosidase inhibitory activity in B. racemosa seed extracts and assigning to bartogenic acid an alpha-glucosidase and amylase inhibitory property. The presence of bartogenic acid in B. racemosa seeds as a major compound is also reported for the first time in this communication.
Gowri
P Mangala
PM
Natural Products Laboratory, Division of Organic Chemistry I, Indian Institute of Chemical Technology, Hyderabad-500 007, India.
Tiwari
Ashok K
AK
Ali
A Zehra
AZ
Rao
J Madhusudana
JM
D000681:Amylases / Q000037:antagonists & inhibitors*; D000818:Animals; D031382:Barringtonia / Q000737:chemistry*; D065089:Glycoside Hydrolase Inhibitors; D007422:Intestines / Q000201:enzymology; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D012639:Seeds / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
D065089:Glycoside Hydrolase Inhibitors; D010936:Plant Extracts; D014315:Triterpenes; C523278:bartogenic acid; D000681:Amylases