title: The effects of stenting and endothelial denudation on aneurysm and branch occlusion in experimental aneurysm models.
abstract: BACKGROUND
  Stents are increasingly used in the endovascular treatment of intracranial aneurysms. We studied the effects of stenting and endothelial denudation on aneurysm and branch vessel occlusion.
  
  
  METHODS
  Bilateral lingual bifurcation venous pouch aneurysms were created in eight dogs, surgically scraping the aneurysmal endothelial lining on one side. Both arteries were immediately stented using balloon-expandable stents. In four other dogs, a wide-neck carotid bifurcation aneurysm was created, with the vein pouch denuded or not (n=2 each), followed by immediate stenting. Results were compared using angiography and pathology at 10 days (n=2), 10 (n=8), and 20 weeks (n=2). Branch occlusion between initial and final angiograms was recorded. Pathological evaluation of aneurysms was studied, with attention to neointima formation at the aneurysm ostium and around branch vessel origins.
  
  
  RESULTS
  All stented and denuded lingual aneurysms were obliterated compared with two of eight lingual aneurysms that were stented alone (P=.007). None of the carotid bifurcation aneurysms became obliterated (0/4), but denuded aneurysms showed partial thrombosis (2/2). Of 68 total stent-covered branches, 5 (7%) were occluded and 17 (27%) had altered angiographic flow.
  
  
  CONCLUSIONS
  Stenting led to suboptimal results in the presence of an intact endothelial layer. Endothelial denudation can promote aneurysm occlusion when combined with stenting.
authors.affiliation: CHUM Notre-Dame Hospital, Montreal, Quebec, Canada.
authors.forename: Tim
authors.initials: T
authors.lastname: Darsaut
authors.forename: Fatiha
authors.initials: F
authors.lastname: Bouzeghrane
authors.forename: Igor
authors.initials: I
authors.lastname: Salazkin
authors.forename: Sophie
authors.initials: S
authors.lastname: Lerouge
authors.forename: Gilles
authors.initials: G
authors.lastname: Soulez
authors.forename: Guylaine
authors.initials: G
authors.lastname: Gevry
authors.forename: Jean
authors.initials: J
authors.lastname: Raymond
mesh_terms: D000783:Aneurysm / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D000818:Animals; D001158:Arteries / Q000601:surgery; D002339:Carotid Arteries / Q000601:surgery; D002340:Carotid Artery Diseases / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D004195:Disease Models, Animal; D004285:Dogs; D004730:Endothelium, Vascular / Q000473:pathology*; D007601:Jugular Veins / Q000601:surgery; D011474:Prosthesis Design; D011859:Radiography; D015607:Stents; D013997:Time Factors; D014059:Tongue / Q000098:blood supply*; D014656:Vascular Surgical Procedures