title: Pre-operative assessment of cancer in the elderly (PACE): a comprehensive assessment of underlying characteristics of elderly cancer patients prior to elective surgery.
abstract: BACKGROUND
  Cancer is a disease that particularly affects the elderly and, although surgery is the first treatment choice, many elderly cancer patients do not receive standard surgery because they are considered unfit for treatment due to an inaccurate estimation of operative risk. Pre-operative Assessment of Cancer in the Elderly (PACE) was developed in order to address the need to provide detailed information about the functional reserve of the elderly cancer patient to aid individualised management.
  
  
  METHODS
  PACE incorporates a battery of validated instruments including the Comprehensive Geriatric Assessment (CGA), Brief Fatigue Inventory (BFI), Eastern Cooperative Oncology Group Performance Status (ECOG-PS), and American Society Anesthesiologists (ASA) grade. An international prospective study was conducted with 460 consecutive elderly cancer patients (216 breast, 146 GIT, 71 GUT, 27 other) receiving PACE prior to receiving elective surgery.
  
  
  RESULTS
  Three hundred and eighty four patients (83.4%) were observed to have at least one co-morbidity; the most common being hypertension (n=246, 53.5%). More than two thirds of the patients had good functional and mental status according to PACE. After adjusting for age, sex and type of cancer, six of the seven items of PACE were found to be significantly associated with co-morbidities (according to the Satariano's Index of Co-morbidities (SIC)). A multivariate analysis identified IADL, BFI and ASA to be the most important instruments in explaining SIC.
  
  
  CONCLUSIONS
  PACE has been effectively used to describe the functional capacity and health status in an international cohort of elderly cancer patients. The majority of PACE instruments have been found to be significantly associated with co-morbidities (SIC) and can distinguish between type and severity of cancer. PACE represents a useful tool in evaluating onco-geriatric fitness for surgery.
authors.affiliation: University of Liverpool, Merseyside, Liverpool, UK.
authors.forename: D
authors.initials: D
authors.lastname: Pope
authors.forename: H
authors.initials: H
authors.lastname: Ramesh
authors.forename: R
authors.initials: R
authors.lastname: Gennari
authors.forename: G
authors.initials: G
authors.lastname: Corsini
authors.forename: M
authors.initials: M
authors.lastname: Maffezzini
authors.forename: H J
authors.initials: HJ
authors.lastname: Hoekstra
authors.forename: D
authors.initials: D
authors.lastname: Mobarak
authors.forename: K
authors.initials: K
authors.lastname: Sunouchi
authors.forename: A
authors.initials: A
authors.lastname: Stotter
authors.forename: C
authors.initials: C
authors.lastname: West
authors.forename: R A
authors.initials: RA
authors.lastname: Audisio
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015897:Comorbidity; D003430:Cross-Sectional Studies; D017558:Elective Surgical Procedures; D005260:Female; D015577:Geriatric Assessment; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000175:diagnosis / Q000601:surgery*; D011300:Preoperative Care; D011446:Prospective Studies