Synthesis of marine alkaloid: 8,9-dihydrocoscinamide B and its analogues as Novel class of antileishmanial agents.
A series of marine alkaloid 8,9-dihydrocoscinamide B, its analogues and indolylglyoxylamide derivatives have been synthesized and screened for their in vitro antileishmanial activity profile in promastigote and amastigote models. Compounds 7 and 10 have shown 99-100% inhibition against promastigotes and 97-98% inhibition against amastigotes at a concentration of 10 microg/ml.
Gupta
Leena
L
Division of Medicinal and Process Chemistry, Central Drug Research Institute, Lucknow 226001, India.
Talwar
Archna
A
Nishi
Palne
Shraddha
S
Gupta
Suman
S
Chauhan
Prem M S
PM
D000818:Animals; D000981:Antiprotozoal Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D026121:Indole Alkaloids / Q000138:chemical synthesis* / Q000494:pharmacology*; D007891:Leishmania / Q000187:drug effects*
C522905:8,9-dihydrocoscinamide B; D000981:Antiprotozoal Agents; D026121:Indole Alkaloids