title: dl-3n-butylphthalide prevents stroke via improvement of cerebral microvessels in RHRSP.
abstract: The purpose of the study is to establish a model of cold-induced stroke in hypertensive rats, and to study the preventive effect of dl-3n-butylphthalide ( NBP ) on stroke. Stroke-prone renovascular hypertension(RHRSP) was created in Sprague-Dawley rats. The animals were assigned randomly to NBP, aspirin treated and vehicle control group, with administration of the medications for 7 days, and then subjected to cold treatment in an environmentally controlled chamber for 3 days to induce the occurrence of stroke. The incidence of stroke, the volume of the brain lesion, patency of the microvessels by FITC-dextran perfusion and the number of microvessels by immunohisochemical detection of vwF were investigated. Cold induced different types of stroke in RHRSP. The incidence of ischemic stroke and the volume of the infarct were decreased, and the perfused microvessels were increased with NBP pretreatment. Our data suggest that NBP prevents cold-induced ischemic stroke via improvement of cerebral microvessels.
authors.affiliation: The Department of Neurology, the First Affiliated Hospital of Sun Yat-sen University, Guang Zhou 510080, PR China.
authors.forename: Chun-Ling
authors.initials: CL
authors.lastname: Liu
authors.forename: Song-Jie
authors.initials: SJ
authors.lastname: Liao
authors.forename: Jin-Sheng
authors.initials: JS
authors.lastname: Zeng
authors.forename: Jian-Wen
authors.initials: JW
authors.lastname: Lin
authors.forename: Chang-Xin
authors.initials: CX
authors.lastname: Li
authors.forename: Long-Chang
authors.initials: LC
authors.lastname: Xie
authors.forename: Xiao-Geng
authors.initials: XG
authors.lastname: Shi
authors.forename: Ru-Xun
authors.initials: RX
authors.lastname: Huang
mesh_terms: D000818:Animals; D001241:Aspirin / Q000627:therapeutic use; D001572:Benzofurans / Q000737:chemistry / Q000627:therapeutic use*; D001921:Brain / Q000098:blood supply / Q000473:pathology / Q000503:physiopathology; D002545:Brain Ischemia / Q000188:drug therapy / Q000503:physiopathology / Q000517:prevention & control; D002536:Cerebral Arteries / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology; D002560:Cerebrovascular Circulation / Q000187:drug effects / Q000502:physiology; D003080:Cold Temperature / Q000009:adverse effects; D003911:Dextrans; D004195:Disease Models, Animal; D016650:Fluorescein-5-isothiocyanate / Q000031:analogs & derivatives; D006977:Hypertension, Renal / Q000150:complications* / Q000503:physiopathology; D008297:Male; D008833:Microcirculation / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology; D015394:Molecular Structure; D018696:Neuroprotective Agents / Q000737:chemistry / Q000627:therapeutic use; D051381:Rats; D017207:Rats, Sprague-Dawley; D020521:Stroke / Q000503:physiopathology / Q000517:prevention & control*; D016896:Treatment Outcome
chemical_list: D001572:Benzofurans; D003911:Dextrans; D018696:Neuroprotective Agents; C015219:fluorescein isothiocyanate dextran; C027125:3-n-butylphthalide; D016650:Fluorescein-5-isothiocyanate; D001241:Aspirin