Hypothermia for neuroprotection after cardiac arrest: mechanisms, clinical trials and patient care.
Therapeutic hypothermia is a proven part of cardio-cerebral resuscitation after cardiac arrest as it improves neurologic outcomes after hypoxic brain injury. This article reviews the mechanisms of hypothermic neuroprotection, the clinical trials that support its use after cardiac arrest, as well as the impact of hypothermia on patient management and prognosis. In caring for patients suffering hypoxic brain injury after cardiac arrest, the role of the neurologist is no longer limited to prognosis but is now to become actively involved in clinical management which includes the use of therapeutic hypothermia.
Froehler
Michael T
MT
Department of Neurology, Johns Hopkins Hospital, 600 N. Wolfe Street, Meyer 8-140, Baltimore, MD 21287, USA. froehler@jhmi.edu
Geocadin
Romergryko G
RG
D002986:Clinical Trials as Topic; D006323:Heart Arrest / Q000453:epidemiology / Q000401:mortality / Q000503:physiopathology* / Q000628:therapy*; D006801:Humans; D007036:Hypothermia, Induced / Q000379:methods*; D016019:Survival Analysis; D014481:United States / Q000453:epidemiology