title: [Local intravenous fibrinolysis in deep cerebral vein thrombosis].
abstract: Acute cerebral vein and dural sinus thrombosis are usually treated with unfractionated intravenous heparin. Progression of symptoms after appropriate heparin dosage appears to be a rare event. In the literature only single case reports or small case series dealing with local intravenous fibrinolysis are available. Here we describe a 44-year-old woman with progressive thrombosis of the sinus rectus and right sinus transversus upon an appropriate dosage of heparin who was successfully treated with urokinase 12 h after symptom onset. This case demonstrates that local thrombolysis should be discussed in patients with progression of the clinical or radiological picture under sufficient heparin therapy.
authors.affiliation: Neurologische Klinik der Universität Ulm im Rehabilitationskrankenhaus Ulm, Oberer Eselsberg 45, Ulm, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Huber
authors.forename: H-J
authors.initials: HJ
authors.lastname: Gdynia
authors.forename: P
authors.initials: P
authors.lastname: Kühnlein
authors.forename: B
authors.initials: B
authors.lastname: Schmitz
mesh_terms: D000328:Adult; D002550:Cerebral Veins / Q000187:drug effects*; D005260:Female; D005343:Fibrinolytic Agents / Q000008:administration & dosage*; D006493:Heparin / Q000008:administration & dosage*; D006801:Humans; D007275:Injections, Intravenous; D020767:Intracranial Thrombosis / Q000175:diagnosis* / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D005343:Fibrinolytic Agents; D006493:Heparin