title: Pulmonary complications of babesiosis: case report and literature review.
abstract: Reported here is a rare case of babesiosis with pulmonary complications followed by a review of the literature. Babesiosis presents clinically as a malaria-like illness with fever, chills, headache, fatigue with lymphopenia, atypical lymphocytes, mildly or transiently elevated serum transaminases, thrombocytopenia, and increased lactate dehydrogenase (LDH) levels. The diagnosis of babesiosis is based on identification of Babesia spp. on a peripheral blood smear. Babesiosis is usually mild in normal hosts, but it may be severe or even fatal in asplenic patients. Pulmonary manifestations are rare in babesiosis, but non-cardiogenic pulmonary edema (NCPE) is the most frequent manifestation. NCPE in babesiosis does not appear to be related to the degree of parasitemia or splenic function and its onset may be early or late. NCPE usually resolves rapidly with supportive treatment; it is rarely fatal. Clinicians should suspect NCPE in patients with babesiosis who acutely develop shortness of breath and have chest radiograph findings compatible with acute pulmonary edema without cardiomegaly or pleural effusions.
authors.affiliation: Infectious Disease Division, Winthrop-University Hospital, Mineola, New York, NY 11501, USA. EMcCaffrey@winthrop.org
authors.forename: B A
authors.initials: BA
authors.lastname: Cunha
authors.forename: S
authors.initials: S
authors.lastname: Nausheen
authors.forename: D
authors.initials: D
authors.lastname: Szalda
mesh_terms: D000743:Anemia, Hemolytic / Q000209:etiology*; D000818:Animals; D001403:Babesia / Q000472:pathogenicity*; D001404:Babesiosis / Q000150:complications* / Q000175:diagnosis; D005260:Female; D006801:Humans; D008875:Middle Aged; D018512:Parasitemia; D011654:Pulmonary Edema / Q000000981:diagnostic imaging / Q000469:parasitology*; D011859:Radiography; D013156:Splenectomy / Q000009:adverse effects*