title: Timing of stenting of symptomatic carotid stenosis is predictive of 30-day outcome.
abstract: For patients with symptomatic carotid stenosis, benefit from carotid artery stenting (CAS) highly depends on the 30-day stroke and death rates. Identification of predictors of unfavourable outcome would help guide the patient selection. We analysed the influence of clinical and angiographic factors on the 30-day outcomes of 77 consecutive patients who underwent CAS for > or = 60% symptomatic carotid stenosis within 180 days of transient ischaemic attack or moderate stroke (modified Rankin Scale score < or = 3). The 30-day composite end-point for stroke (7.8%) and death of any cause (1.3%) was 9.1%. Patients with complicated CAS were older than patients with uncomplicated CAS (mean age 75.1 +/- 8.2 vs. 65.9 +/- 9.5 years, P = 0.015) and underwent stenting significantly earlier after the qualifying event: median delay 1.5 weeks (range: 0.2-3.0) vs. 3.2 weeks (range: 0.5-26), P = 0.004. In multivariate logistic regression analyses, age [odds ratio (OR) = 1.148; 95% confidence interval (CI): 1.011-1.304 and P = 0.033] and delay of treatment < 2 weeks (OR = 22.399; 95% CI: 2.245-223.445 and P = 0.008) remained the only variables significantly associated with 30-day outcome. CAS carries a considerable risk in old patients and when performed early (< 2 weeks) after the qualifying event. Future reports should address the timing of CAS.
authors.affiliation: Department of Neurology, Academic Teaching Hospital Wagner-Jauregg Linz, Austria. raffi.topakian@hotmail.com
authors.forename: R
authors.initials: R
authors.lastname: Topakian
authors.forename: A M
authors.initials: AM
authors.lastname: Strasak
authors.forename: M
authors.initials: M
authors.lastname: Sonnberger
authors.forename: H-P
authors.initials: HP
authors.lastname: Haring
authors.forename: K
authors.initials: K
authors.lastname: Nussbaumer
authors.forename: J
authors.initials: J
authors.lastname: Trenkler
authors.forename: F T
authors.initials: FT
authors.lastname: Aichner
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017130:Angioplasty / Q000379:methods; D002340:Carotid Artery Diseases / Q000175:diagnosis* / Q000401:mortality; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D011237:Predictive Value of Tests; D012044:Regression Analysis; D012189:Retrospective Studies; D015607:Stents / Q000009:adverse effects*; D020521:Stroke / Q000175:diagnosis* / Q000401:mortality / Q000601:surgery; D013997:Time Factors