New aromatic nitro compounds from Salegentibacter sp. T436, an Arctic Sea ice bacterium: taxonomy, fermentation, isolation and biological activities.
Nineteen aromatic nitro compounds were isolated from the culture broth of an Arctic sea ice bacterium. Four of these compounds are new and six compounds are reported from a natural source for the first time. The new natural products showed weak antimicrobial and cytotoxic activities. 2-nitro-4-(2'-nitroethenyl)-phenol was the most potent antimicrobial and cytotoxic substance. Some of the compounds exhibit plant growth modulating activities. Based on its biochemical properties and the 16S rRNA gene sequence, the producing strain can be described as a distinct species within the genus Salegentibacter.
Al-Zereini
Wael
W
Institute for Biotechnology and Drug Research (IBWF), Kaiserslautern, Germany.
Schuhmann
Imelda
I
Laatsch
Hartmut
H
Helmke
Elisabeth
E
Anke
Heidrun
H
D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology*; D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification / Q000494:pharmacology; D001110:Arctic Regions; D001419:Bacteria / Q000737:chemistry* / Q000145:classification* / Q000187:drug effects / Q000648:ultrastructure; D045744:Cell Line, Tumor; D004269:DNA, Bacterial / Q000737:chemistry / Q000235:genetics; D004354:Drug Screening Assays, Antitumor; D005285:Fermentation; D005658:Fungi / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D009574:Nitro Compounds / Q000302:isolation & purification / Q000494:pharmacology*; D010101:Oxygen Consumption / Q000187:drug effects; D017422:Sequence Analysis, DNA
D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D004269:DNA, Bacterial; D009574:Nitro Compounds