Two new sesquiterpenes from Alisma orientalis.
Two new sesquiterpenoids named alismorientols A (1) and B (2) were isolated from the rhizomes of Alisma orientalis collected in Sichuan province, People's Republic of China. Their structures were elucidated based on spectroscopic analyses (1D and 2D NMR data including HSQC, HMBC, COSY, and ROESY) and X-ray crystallographic analysis. Anti-hepatitis B virus (HBV) bioassay revealed that compound 1 showed moderate anti-HBV activity in vitro with IC50 for HBsAg: 1.1 microM, for HBeAg: 14.7 microM.
Jiang
Zhi-Yong
ZY
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Yunnan, PR China.
Zhang
Xue-Mei
XM
Zhou
Jun
J
Zhang
Feng-Xue
FX
Chen
Ji-Jun
JJ
Lü
Yang
Y
Wu
Li
L
Zheng
Qi-Tai
QT
D034902:Alisma / Q000737:chemistry*; D018360:Crystallography, X-Ray; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification*; D013055:Spectrophotometry, Infrared
D012717:Sesquiterpenes