Pneumatosis intestinalis and portal venous gas without bowel ischemia in a patient treated with irinotecan and cisplatin.
Pneumatosis intestinalis and gas within the portal venous system are findings predictive of bowel ischemia. The etiologies of these alarming radiographic signs are diverse and not all causes require emergent surgical intervention. The combination of pneumatosis intestinalis, portal venous gas, and acidosis typically portends bowel ischemia and inevitable necrosis. This case report is the first description of benign pneumatosis and portal venous gas secondary to irinotecan and cisplatin.
Kung
David
D
Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Ruan
Daniel T
DT
Chan
Rodney K
RK
Ericsson
Melissa L
ML
Saund
Mandeep S
MS
D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002166:Camptothecin / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D002945:Cisplatin / Q000009:adverse effects* / Q000627:therapeutic use; D003106:Colon / Q000098:blood supply; D003937:Diagnosis, Differential; D004618:Embolism, Air / Q000139:chemically induced* / Q000000981:diagnostic imaging; D004938:Esophageal Neoplasms / Q000188:drug therapy; D005500:Follow-Up Studies; D006801:Humans; D007421:Intestine, Small / Q000098:blood supply; D000077146:Irinotecan; D007511:Ischemia / Q000175:diagnosis* / Q000601:surgery; D007813:Laparotomy; D008297:Male; D011006:Pneumatosis Cystoides Intestinalis / Q000139:chemically induced* / Q000000981:diagnostic imaging; D011169:Portal Vein; D011355:Prodrugs; D014057:Tomography, X-Ray Computed
D000970:Antineoplastic Agents; D011355:Prodrugs; D000077146:Irinotecan; D002945:Cisplatin; D002166:Camptothecin