title: Imaging the whole body atherosclerosis: high resolution magnetic resonance angiography using blood-pool agent. Initial clinical experience.
abstract: OBJECTIVE
  Recently whole-body 3D MR angiography (MRA) with blood-pool contrast agent has become available. The purpose of this study was to introduce and evaluate this technique to demonstrate arterial steno-occlusive involvement in systemic atherosclerosis and to compare blood-pool enhanced MRA results with those of CT angiography (CTA) as reference modality.
  
  
  METHODS
  Twenty patients with clinically and US documented carotid occlusive disease underwent whole-body MRA on a 1.5 T scanner and CTA on a 64-MDCT unit. Ten milliliters of a blood-pool agent (MS-235 Gadofosveset Trisodium, VASOVIST, Schering, Berlin, Germany) were administered intravenously and four 3-D MRA stations were acquired successively through automatic table moving. Images were reviewed by two observers. Overall image quality of each arterial segment was assessed and rated for both MRA and CTA examinations; MRA sensitivity, MRA specificity interobserver and intermodality agreement were calculated.
  
  
  RESULTS
  Whole-body MRA with blood-pool contrast agent was well tolerated by all patients. It yielded a detailed display of the arterial system with a short examination time. In 14 out of 20 patients there was extensive involvement of the arterial bed by steno-occlusive atherosclerotic disease; for the identification and characterization of vessel damage in the various vascular districts MRA sensitivity was 92-100%, MRA specificity was 95-100%; in 2 cases MRA underestimated the degree of peripheral vessel stenosis. Interobserver agreement calculated with K value was 0.63, intermodality agreement with CTA was 93% (P<0.01).
  
  
  CONCLUSIONS
  The whole-body MRA technique is a valuable tool for comprehensive evaluation of arterial steno-occlusive involvement in systemic arterial atherosclerosis; there is a good agreement between blood-pool enhanced MRA results and CTA, used as modality of reference.
authors.affiliation: Department of Radiological Sciences, University of Rome La Sapienza, Rome, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Napoli
authors.forename: C
authors.initials: C
authors.lastname: Catalano
authors.forename: M
authors.initials: M
authors.lastname: Anzidei
authors.forename: K
authors.initials: K
authors.lastname: Lanciotti
authors.forename: F A
authors.initials: FA
authors.lastname: Calabrese
authors.forename: B
authors.initials: B
authors.lastname: Cavallo Marincola
authors.forename: C
authors.initials: C
authors.lastname: Zini
authors.forename: P L
authors.initials: PL
authors.lastname: Di Paolo
authors.forename: T
authors.initials: T
authors.lastname: Kyventidis
authors.forename: R
authors.initials: R
authors.lastname: Passariello
mesh_terms: D000368:Aged; D050197:Atherosclerosis / Q000175:diagnosis*; D003287:Contrast Media / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D018810:Magnetic Resonance Angiography / Q000379:methods; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000379:methods; D051598:Whole Body Imaging / Q000379:methods*
chemical_list: D003287:Contrast Media