title: Plasma protein variations in hemophiliacs receiving factor replacement therapy.
abstract: OBJECTIVE
  Post transfusion manifestations and its affiliated factors are vital to understand in a disease like hemophilia where multi-transfusions are given to the patients.
  
  
  METHODS
  To investigate the implications of factor replacement therapy on plasma proteins, 52 hemophiliacs and 68 carrier females were examined for 12 plasma proteins using various electrophoretic techniques.
  
  
  RESULTS
  Severe hemophiliacs showed raised levels ( p< 0.05) of a2 M, IgG and Albumins where values were found to be 4.78 +/- 0.865 g/l, 21.48 +/- 3.38 g/l, 66.26 +/- 11.92 g/l respectively at 95% confidence intervals however, controls and carriers showed trivial variations.
  
  
  CONCLUSIONS
  Juxtaposing the dissimilarities of 12 plasma proteins in carriers, controls and hemophiliacs, it has been gleaned that factor replacement therapy do play role when seen in severe hemophiliacs with raised levels.
authors.affiliation: Department of Human Biology, Punjabi University, Patiala, India. singh_m12@rediffmail.com
authors.forename: Monica
authors.initials: M
authors.lastname: Singh
authors.forename: Puneetpal
authors.initials: P
authors.lastname: Singh
authors.forename: Harsurinder
authors.initials: H
authors.lastname: Kaur
mesh_terms: D000925:Anticoagulants / Q000627:therapeutic use*; D001798:Blood Proteins / Q000032:analysis*; D004587:Electrophoresis, Agar Gel; D005169:Factor VIII / Q000627:therapeutic use*; D005260:Female; D006467:Hemophilia A / Q000097:blood*; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D008297:Male
chemical_list: D000925:Anticoagulants; D001798:Blood Proteins; D007074:Immunoglobulin G; D005169:Factor VIII