title: Challenges and progress in pediatric inflammatory bowel disease.
abstract: OBJECTIVE
  The induction and maintenance of disease remission and prevention of complications are primary goals in the management of inflammatory bowel disease. Recent research has added new insights into the pathogenesis, epidemiology, and treatment options for children with inflammatory bowel disease, and the findings will enable clinicians to develop a more rational approach to the diagnosis and treatment of pediatric patients with ulcerative colitis and Crohn's disease.
  
  
  RESULTS
  Population-based studies have confirmed the increased incidence of inflammatory bowel disease in children. Previous medical history and serologies can be predictive of complications in Crohn's disease. Newer radiological and capsule endoscopic modalities have a potential future role in the diagnosis and interval assessment of patients with inflammatory bowel disease. Biological therapies play an increasingly prominent role in the management of children with ulcerative colitis and Crohn's disease. Studies of children with inflammatory bowel disease suggest that behavioral interventions may have a positive impact on morbidity and overall quality of life.
  
  
  CONCLUSIONS
  New information concerning the natural history of Crohn's disease and ulcerative colitis and a better understanding of different treatment modalities will enable the development of increasingly effective and individualized pharmacological treatment plans for children with inflammatory bowel disease.
authors.affiliation: Children's Hospital Boston, Inflammatory Bowel Disease Center, Boston, Massachusetts 02115, USA. paul.rufo@childrens.harvard.edu
authors.forename: Paul A
authors.initials: PA
authors.lastname: Rufo
authors.forename: Athos
authors.initials: A
authors.lastname: Bousvaros
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D053704:Capsule Endoscopy; D002648:Child; D041981:Gastrointestinal Tract / Q000000981:diagnostic imaging; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D015212:Inflammatory Bowel Diseases / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology / Q000628:therapy*; D009752:Nutritional Status; D011788:Quality of Life; D011859:Radiography
chemical_list: D000893:Anti-Inflammatory Agents; D007166:Immunosuppressive Agents