Growth related oncogene-alpha (GRO-alpha): roles in atherosclerosis, angiogenesis and other inflammatory conditions.
Growth related oncogene-alpha (GRO-alpha) is a member of the CXC chemokine family with an internal glutamate-leucine-arginine (ELR) motif. It was initially isolated and characterized by its growth stimulatory activity on malignant melanoma cells. Recently, many new functions and properties of GRO-alpha have been discovered and associated with atherosclerosis, angiogenesis and many inflammatory conditions. Purpose of this review is to overview current advances of multiple functions of GRO-alpha and its associated molecular mechanisms and clinical implications. We hope to further evaluate this molecule in the pathogenesis of atherosclerosis as well as angiogenesis to promote a background for therapeutic interventions.
Bechara
Carlos
C
Molecular Surgeon Research Center, Division of Vascular Surgery and Endovascular Therapy, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA.
Chai
Hong
H
Lin
Peter H
PH
Yao
Qizhi
Q
Chen
Changyi
C
D000818:Animals; D050197:Atherosclerosis / Q000378:metabolism*; D019743:Chemokines, CXC / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D007249:Inflammation / Q000378:metabolism*; D007962:Leukocytes / Q000378:metabolism; D009389:Neovascularization, Pathologic / Q000378:metabolism*
D019743:Chemokines, CXC