title: Transmission of multidrug-resistant HIV-1: 5 years of immunological and virological survey.
abstract: Multidrug resistant HIV-1 acquired at the time of primary infection in two patients persisted for at least 5 years with and without treatment. In each patient, only one back mutation to wild-type codon in the protease gene occurred, and that was concomitantly associated with a marked CD4 cell count decrease. In both cases, infection was caused by CCR5 viruses and no rapid clinical progression to AIDS after primary infection was observed.
authors.affiliation: Department of Virology-EA3620, Necker Hospital, Paris, France.
authors.forename: Constance
authors.initials: C
authors.lastname: Delaugerre
authors.forename: Anne-Genevieve
authors.initials: AG
authors.lastname: Marcelin
authors.forename: Cathia
authors.initials: C
authors.lastname: Soulié
authors.forename: Marie-Laure
authors.initials: ML
authors.lastname: Chaix
authors.forename: Christine
authors.initials: C
authors.lastname: Katlama
authors.forename: Pierre-Marie
authors.initials: PM
authors.lastname: Girard
authors.forename: Vincent
authors.initials: V
authors.lastname: Calvez
authors.forename: Laurence
authors.initials: L
authors.lastname: Morand-Joubert
mesh_terms: D000225:Adenine / Q000031:analogs & derivatives / Q000627:therapeutic use; D044966:Anti-Retroviral Agents / Q000627:therapeutic use*; D018791:CD4 Lymphocyte Count; D024921:Drug Resistance, Multiple, Viral / Q000276:immunology; D015658:HIV Infections / Q000276:immunology / Q000635:transmission* / Q000821:virology; D017320:HIV Protease Inhibitors / Q000627:therapeutic use; D015497:HIV-1 / Q000187:drug effects / Q000235:genetics / Q000276:immunology*; D006801:Humans; D019259:Lamivudine / Q000627:therapeutic use; D061466:Lopinavir; D009154:Mutation / Q000235:genetics / Q000276:immunology; D063065:Organophosphonates / Q000627:therapeutic use; D011744:Pyrimidinones / Q000627:therapeutic use; D012367:RNA, Viral / Q000032:analysis; D018894:Reverse Transcriptase Inhibitors / Q000627:therapeutic use; D019438:Ritonavir / Q000627:therapeutic use; D000068698:Tenofovir; D019562:Viral Load
chemical_list: D044966:Anti-Retroviral Agents; D017320:HIV Protease Inhibitors; D063065:Organophosphonates; D011744:Pyrimidinones; D012367:RNA, Viral; D018894:Reverse Transcriptase Inhibitors; D061466:Lopinavir; D019259:Lamivudine; D000068698:Tenofovir; D000225:Adenine; D019438:Ritonavir