title: Natural course of intraocular pressure after cataract surgery with sodium hyaluronate 1% versus hydroxypropylmethylcellulose 2%.
abstract: OBJECTIVE
  To investigate the natural course of intraocular pressure (IOP) after small-incision cataract surgery with sodium hyaluronate 1% versus hydroxypropylmethylcellulose 2%.
  
  
  METHODS
  Randomized clinical trial.
  
  
  METHODS
  Eighty eyes of 40 consecutive patients with bilateral age-related cataract.
  
  
  METHODS
  The patients were assigned randomly to receive sodium hyaluronate 1% or hydroxypropylmethylcellulose 2% during cataract surgery in the first eye. The second eye received the other ophthalmic viscosurgical device. The IOP was measured preoperatively and 30 minutes; 1, 2, 3, 4, 6, 8, and 20 to 24 hours; and 1 week postoperatively.
  
  
  METHODS
  Postoperative IOP increase.
  
  
  RESULTS
  The highest mean IOP increase occurred at 8 hours postoperatively (5.3+/-6.4 mmHg) in the sodium hyaluronate 1% group and at 2 hours postoperatively (7.8+/-6.1 mmHg) in the hydroxypropylmethylcellulose 2% group. Overall, the IOP increase was higher with hydroxypropylmethylcellulose 2% (P = 0.005). Intraocular pressure spikes to > or =30 mmHg occurred in 5 eyes (13%) in the sodium hyaluronate 1% group and 13 eyes (33%) in the hydroxypropylmethylcellulose 2% group.
  
  
  CONCLUSIONS
  Sodium hyaluronate 1% and hydroxypropylmethylcellulose 2% caused significant IOP increases during the first 8 hours after cataract surgery. A single measurement at 6 hours postoperatively could detect all IOP spikes in the sodium hyaluronate 1% group. In the hydroxypropylmethylcellulose 2% group, a single measurement at 2 hours postoperatively could detect two thirds of IOP spikes.
authors.affiliation: Department of Ophthalmology, Medical University of Vienna, Vienna, Austria. georg.rainer@meduniwien.ac.at
authors.forename: Georg
authors.initials: G
authors.lastname: Rainer
authors.forename: Katharina Emanuela
authors.initials: KE
authors.lastname: Schmid
authors.forename: Oliver
authors.initials: O
authors.lastname: Findl
authors.forename: Stefan
authors.initials: S
authors.lastname: Sacu
authors.forename: Barbara
authors.initials: B
authors.lastname: Kiss
authors.forename: Harald
authors.initials: H
authors.lastname: Heinzl
authors.forename: Rupert
authors.initials: R
authors.lastname: Menapace
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage*; D065347:Hypromellose Derivatives; D007429:Intraocular Pressure / Q000502:physiology*; D019654:Lens Implantation, Intraocular; D008297:Male; D008747:Methylcellulose / Q000008:administration & dosage / Q000031:analogs & derivatives*; D009798:Ocular Hypertension / Q000503:physiopathology; D018918:Phacoemulsification / Q000379:methods*; D011184:Postoperative Period; D011446:Prospective Studies; D019591:Pseudophakia / Q000503:physiopathology; D014065:Tonometry, Ocular
chemical_list: D065347:Hypromellose Derivatives; D006820:Hyaluronic Acid; D008747:Methylcellulose