AML1 mutation and its coexistence with different transcription factor gene families in de novo acute myeloid leukemia (AML): redundancy or synergism.
AML1 mutations were identified in 6.3% of AML patients with chromosomal translocations involving CBF, PML-RARalpha, HOX, or ETS transcription factor (TF) gene families. Rare chromosomal abnormalities, t(16;21) and t(7;11), were also found. This study represents the first series to demonstrate the coexistence of known and novel AML1 mutations with different TF gene mutations. Although the occurrence of two TF gene mutations may appear unnecessary, the possible synergistic mechanism between different TF gene families cannot be excluded and needs to be further explored.
Auewarakul
Chirayu U
CU
Leecharendkeat
Amporn
A
Tocharoentanaphol
Chintana
C
Promsuwicha
Orathai
O
Sritana
Narongrit
N
Thongnoppakhun
Wanna
W
D050676:Core Binding Factor Alpha 2 Subunit / Q000235:genetics*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D005810:Multigene Family; D009154:Mutation; D013925:Thromboplastin / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics*; D014178:Translocation, Genetic
D050676:Core Binding Factor Alpha 2 Subunit; C493728:RUNX1 protein, human; D014157:Transcription Factors; D013925:Thromboplastin