Sugar sensing based on induced pH changes.
A sensory assembly consisting of a pH sensitive NIR dye and an arylboronic acid shows ratiometric absorption changes with increased fluorescence intensity upon addition of sugar in aqueous media; this demonstrates a new signal transduction mechanism for the detection of sugar based on pH changes induced in the microenvironment of the sensory assembly.
Kim
Youngmi
Y
Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA.
Hilderbrand
Scott A
SA
Weissleder
Ralph
R
Tung
Ching-Hsuan
CH
D000042:Absorption; D015374:Biosensing Techniques; D001897:Boronic Acids / Q000737:chemistry*; D002241:Carbohydrates / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000737:chemistry*; D006841:Hydrocarbons, Aromatic / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D007259:Infrared Rays; D012995:Solubility; D013050:Spectrometry, Fluorescence; D014867:Water / Q000737:chemistry
D001897:Boronic Acids; D002241:Carbohydrates; D005456:Fluorescent Dyes; D006841:Hydrocarbons, Aromatic; D014867:Water