title: Adenosine phosphonate inhibitors of lipid II: alanyl tRNA ligase MurM from Streptococcus pneumoniae.
abstract: Adenosine and 2'-deoxyadenosine phosphonate transition state analogues act as the first inhibitors for the MurMN/FemABX family of tRNA-dependent ligases implicated in high-level penicillin resistance in gram-positive bacteria.
authors.affiliation: Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK.
authors.forename: Elena
authors.initials: E
authors.lastname: Cressina
authors.forename: Adrian J
authors.initials: AJ
authors.lastname: Lloyd
authors.forename: Gianfranco
authors.initials: G
authors.lastname: De Pascale
authors.forename: David I
authors.initials: DI
authors.lastname: Roper
authors.forename: Christopher G
authors.initials: CG
authors.lastname: Dowson
authors.forename: Timothy D H
authors.initials: TD
authors.lastname: Bugg
mesh_terms: D000227:Adenine Nucleotides / Q000737:chemistry* / Q000494:pharmacology*; D001426:Bacterial Proteins; D015394:Molecular Structure; D010453:Peptide Synthases; D013296:Streptococcus pneumoniae / Q000187:drug effects / Q000201:enzymology; D014538:Uridine Diphosphate N-Acetylmuramic Acid / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors
chemical_list: D000227:Adenine Nucleotides; D001426:Bacterial Proteins; D014538:Uridine Diphosphate N-Acetylmuramic Acid; C069249:muramyl-NAc-(pentapeptide)pyrophosphoryl-undecaprenol; C408066:MurM protein, Streptococcus pneumoniae; D010453:Peptide Synthases