title: Design of a partial PPARdelta agonist.
abstract: Structure based ligand design was used in order to design a partial agonist for the PPARdelta receptor. The maximum activation in the transactivation assay was reduced from 87% to 39%. The crystal structure of the ligand binding domain of the PPARdelta receptor in complex with compound 2 was determined in order to understand the structural changes which gave rise to the decrease in maximum activation.
authors.affiliation: Novo Nordisk A/S, Novo Nordisk Park, 2760 Måløv, Denmark. inpe@novonordisk.com
authors.forename: Ingrid
authors.initials: I
authors.lastname: Pettersson
authors.forename: Søren
authors.initials: S
authors.lastname: Ebdrup
authors.forename: Miroslav
authors.initials: M
authors.lastname: Havranek
authors.forename: Pavel
authors.initials: P
authors.lastname: Pihera
authors.forename: Marek
authors.initials: M
authors.lastname: Korínek
authors.forename: John P
authors.initials: JP
authors.lastname: Mogensen
authors.forename: Claus B
authors.initials: CB
authors.lastname: Jeppesen
authors.forename: Eva
authors.initials: E
authors.lastname: Johansson
authors.forename: Per
authors.initials: P
authors.lastname: Sauerberg
mesh_terms: D002087:Butyrates / Q000737:chemistry* / Q000494:pharmacology*; D015195:Drug Design; D008958:Models, Molecular; D015394:Molecular Structure; D047494:PPAR delta / Q000819:agonists*; D010671:Phenylurea Compounds / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D002087:Butyrates; C110636:GW 2433; C425931:GW 501516; D047494:PPAR delta; D010671:Phenylurea Compounds; D013844:Thiazoles