Evaluation of microalbuminuria after non-ionic radiocontrast medium exposure in patients undergoing coronary angiography.
Transient and massive glomerular proteinuria, previously reported as one of the nephrotoxic reactions after ionic radiocontrast medium (RCM) exposure, is rarely observed in patients since the introduction of non-ionic RCM. However, whether the very low-range microalbuminuria might be encountered after non-ionic RCM exposure remains unknown. In this study we sought to investigate the effects of non-ionic RCM (Ultravist 370) exposure on the presence of microalbuminuria, defined as urine albumin-to-creatinine ratio (UACR) >30 mg/g, by a turbidmetric method in total of 64 patients (17 female, mean age 58+/-12 years) undergoing coronary angiography. The results showed that after non-ionic RCM (mean volume 103+/-57 ml) exposure, no significant differences were found in urinary albumin concentration or UACR; however, urinary creatinine was significantly reduced from 116+/-62 to 69+/-43 mg/dl (p<0.001). Changes in the presence of microalbuminuria before and after procedure were also not significant (p=0.891, McNemar test). In conclusion, non-ionic RCM exposure during CAG had negligible effect on the excretion of urinary albumin even within the detection range of microalbuminuria.
Cheng
Kai-Hong
KH
Chu
Chih-Sheng
CS
Lee
Kun-Tai
KT
Lin
Tsung-Hsien
TH
Voon
Wen-Chol
WC
Tsai
Li-Yu
LY
Sheu
Sheng-Hsiung
SH
Lai
Wen-Ter
WT
D000419:Albuminuria / Q000139:chemically induced*; D003287:Contrast Media / Q000009:adverse effects*; D017023:Coronary Angiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018709:Statistics, Nonparametric
D003287:Contrast Media