[Changes of CD4+CD28- T cell and CD4+CD25+ regulatory T cell subsets in patients with coronary heart disease].
OBJECTIVE
To investigate the changes of CD4(+)CD28(-) T cell and CD4(+)CD25(+) regulatory T cell (Treg) subsets in patients with coronary artery disease (CAD).


METHODS
Twenty-eight patients with angiographically established CAD were recruited in this study, including 16 with unstable angina (UA group) and 12 with stable angina (SA group). Eleven patients with chest pain syndrome served as the control group. The proportions of peripheral CD4(+)CD28(-) T cells and CD4(+)CD25(+) Treg subsets were determined with fluorescence-activated cell sorting (FACS).


RESULTS
The proportions of CD4(+)CD25(+) Treg were significantly lower in UA group (6.55-/+2.45%) than in SA (14.01-/+4.92%) and control groups (13.55-/+3.87%). The proportions of CD4(+)CD28(-) T cells were significantly higher in UA group (10.55-/+4.76%) than in SA (2.64-/+1.33%) and control (2.75-/+1.55%) groups.


CONCLUSIONS
Alterations of circulating T-lymphocyte subsets occur in patients with UA. The changes of Treg and CD4(+)CD28(-) T cells may lead to breakdown of peripheral autoimmune tolerance and play an important role in the development and progression of CHD.
Zhao
Yi-qiao
YQ
Department of Cardiology, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, China.
Fu
Qiang
Q
Li
Zhi-liang
ZL
Yan
Quan-neng
QN
Wu
Hong-chao
HC
Miao
Fei
F
Lü
Yong-heng
YH
Liu
Ying-feng
YF
D000368:Aged; D000789:Angina, Unstable / Q000276:immunology; D018106:CD28 Antigens; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D016022:Case-Control Studies; D003327:Coronary Disease / Q000276:immunology*; D005260:Female; D006801:Humans; D053645:Interleukin-2 Receptor alpha Subunit; D008297:Male; D008875:Middle Aged; D016176:T-Lymphocyte Subsets / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D018106:CD28 Antigens; D053645:Interleukin-2 Receptor alpha Subunit