Brugada type electrocardiographic changes induced by concomitant use of lithium and propafenone in patient with Wolff-Parkinson-White syndrome.
We report a case of ST elevation in right precordial leads compatible with type 1 Brugada syndrome following administration of propafenone in a patient with Wolff-Parkinson-White syndrome who was receiving lithium at concentrations within therapeutic levels. The mechanism of the electrocardiogram changes was considered to be caused by the two drugs synergistic sodium channel blocking effects.
Fragakis
Nikolaos
N
Second Cardiac Department, GH G. Papanikolaou, Thessaloniki, Greece. nfrag@panafonet.gr
Iliadis
Ilias
I
Papanastasiou
Soultana
S
Lambrou
Alexandra
A
Katsaris
George
G
D053840:Brugada Syndrome / Q000139:chemically induced* / Q000503:physiopathology; D004562:Electrocardiography; D005260:Female; D006801:Humans; D018020:Lithium Compounds / Q000009:adverse effects*; D008875:Middle Aged; D011405:Propafenone / Q000009:adverse effects*; D014927:Wolff-Parkinson-White Syndrome / Q000188:drug therapy*
D018020:Lithium Compounds; D011405:Propafenone