New aureothin derivative, alloaureothin, from Streptomyces sp. MM23.
A new polypropionate alloaureothin (1) possessing a nitro group, together with a known polypropionate aureothin (2), was isolated from mycelium of Streptomyces sp. MM23. The structure was determined on the basis of spectroscopic data. 1 exhibited growth inhibitory effect against human fibrosarcoma HT1080 cells with an IC50 value of 30 microM.
Ueda
Jun-ya
JY
Japan Biological Information Research Center (JBIRC), Japan Biological Informatics Consortium (JBIC).
Hashimoto
Junko
J
Nagai
Aya
A
Nakashima
Takuji
T
Komaki
Hisayuki
H
Anzai
Kozue
K
Harayama
Shigeaki
S
Doi
Takayuki
T
Takahashi
Takashi
T
Nagasawa
Kazuo
K
Natsume
Tohru
T
Takagi
Motoki
M
Shin-ya
Kazuo
K
D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002851:Chromatography, High Pressure Liquid; D002867:Chromones / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D025282:Mycelium / Q000737:chemistry; D012988:Soil Microbiology; D021241:Spectrometry, Mass, Electrospray Ionization; D013056:Spectrophotometry, Ultraviolet; D013302:Streptomyces / Q000737:chemistry*
D000903:Antibiotics, Antineoplastic; D002867:Chromones; C012198:aureothin