Specific sensing of poly G by the aluminum-salophen complex.
The Al(III)-salophen complex 1 exhibited strong spectroscopic changes specifically upon addition of polyG and GpG, while double stranded DNA and RNA, and single stranded polyA, polyU and polyC induced negligible spectral changes of 1. Titrations with mono-nucleotides yielded no spectroscopic changes, revealing that there must be at least two consecutive guanines in single stranded oligonucleotide structure for a measurable spectroscopic change of 1. Preliminary results show that 1 has moderate antiproliferative effect on a number of human tumour cell lines.
Cametti
Massimo
M
Dipartimento di Chimica and IMC-CNR, Università La Sapienza, Box 34, Roma 62, Italy.
Piantanida
Ivo
I
Zinić
Mladen
M
Dalla Cort
Antonella
A
Mandolini
Luigi
L
Marjanović
Marko
M
Kralj
Marijeta
M
D000535:Aluminum / Q000737:chemistry* / Q000378:metabolism; D000818:Animals; D001665:Binding Sites; D045744:Cell Line, Tumor; D004247:DNA / Q000378:metabolism; D006367:HeLa Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D011068:Poly G / Q000737:chemistry* / Q000378:metabolism; D012459:Salicylates / Q000737:chemistry* / Q000378:metabolism; D012995:Solubility; D013056:Spectrophotometry, Ultraviolet; D055672:Static Electricity
D012459:Salicylates; C090416:salophen; D011068:Poly G; D004247:DNA; C427203:calf thymus DNA; D000535:Aluminum