title: Possible novel receptor for PGD2 on human bronchial epithelial cells.
abstract: Prostaglandin D(2) (PGD(2)), a major prostanoid produced by activated mast cells, has long been implicated in allergic diseases. Recent studies have shown that PGD(2) exerts its effects through two different G-protein-coupled receptors (GPCRs), the D-prostanoid receptor (DP) and the chemoattractant receptor-homologous molecule expressed on T helper type-2 cells (CRTH2), expressed in various human tissues. The PGD(2)/CRTH2 system mediates the chemotaxis of eosinophils, basophils, and Th2 cells, which are involved in the induction of allergic inflammation. We have reported that normal human bronchial epithelial cells (NHBE) and epithelial cell lines (NCI-H(292)) expressed CRTH2, and PGD(2) induces production of IL-8 and GM-CSF. This review discusses the role of CRTH2/DP on epithelial cells and mentions a possible novel receptor for PGD(2).
authors.affiliation: Department of Clinical and Laboratory Medicine, Akita University School of Medicine, Akita, Japan.
authors.forename: Takahito
authors.initials: T
authors.lastname: Chiba
authors.forename: Akira
authors.initials: A
authors.lastname: Kanda
authors.forename: Shigeharu
authors.initials: S
authors.lastname: Ueki
authors.forename: Wataru
authors.initials: W
authors.lastname: Ito
authors.forename: Kazutoshi
authors.initials: K
authors.lastname: Yamaguchi
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Kamada
authors.forename: Masahide
authors.initials: M
authors.lastname: Takeda
authors.forename: Tomomi
authors.initials: T
authors.lastname: Tanigai
authors.forename: Hajime
authors.initials: H
authors.lastname: Oyamada
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kayaba
authors.forename: Junichi
authors.initials: J
authors.lastname: Chihara
mesh_terms: D001249:Asthma / Q000503:physiopathology; D001980:Bronchi / Q000166:cytology*; D001991:Bronchitis / Q000209:etiology / Q000503:physiopathology; D002460:Cell Line / Q000187:drug effects / Q000378:metabolism; D002633:Chemotaxis / Q000187:drug effects / Q000502:physiology; D004847:Epithelial Cells / Q000737:chemistry* / Q000187:drug effects / Q000502:physiology; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000096:biosynthesis; D006801:Humans; D016209:Interleukin-8 / Q000096:biosynthesis; D020935:MAP Kinase Signaling System / Q000187:drug effects; D009928:Organ Specificity; D015230:Prostaglandin D2 / Q000494:pharmacology / Q000502:physiology*; D012333:RNA, Messenger / Q000096:biosynthesis; D011971:Receptors, Immunologic / Q000819:agonists / Q000145:classification / Q000302:isolation & purification / Q000502:physiology*; D011982:Receptors, Prostaglandin / Q000819:agonists / Q000145:classification / Q000302:isolation & purification / Q000502:physiology*; D012130:Respiratory Hypersensitivity / Q000503:physiopathology; D018418:Th2 Cells / Q000276:immunology
chemical_list: D016209:Interleukin-8; D012333:RNA, Messenger; D011971:Receptors, Immunologic; D011982:Receptors, Prostaglandin; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D015230:Prostaglandin D2; C036293:prostaglandin D2 receptor