Testosterone deficiency and the metabolic syndrome.
Evidence is presented to link components of the metabolic syndrome to testosterone deficiency and obesity. Testosterone deficiency in hypogonadism or testosterone deprivation in normo-gonadotropic men increases fat mass as well as fasting insulin levels. Testosterone supplementation (TS) in a dose dependent manner, increase lean body mass (LBM), reduces fat mass, body mass index (BMI) and waist hip ratio in both young and elderly hypogonadal men. A negative association between T and insulin resistance as well as impaired glucose intolerance has been demonstrated and in type 2 diabetic men TS improves metabolic parameters. TS improves most components of the metabolic syndrome and also reduces inflammatory cytokines.
Lunenfeld
Bruno
B
Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, Israel. blunenf@attglobal.net
D000728:Androgens / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism; D019317:Evidence-Based Medicine; D006801:Humans; D007006:Hypogonadism / Q000378:metabolism; D007557:Israel; D008297:Male; D024821:Metabolic Syndrome / Q000209:etiology* / Q000503:physiopathology; D009765:Obesity / Q000503:physiopathology; D013739:Testosterone / Q000172:deficiency* / Q000378:metabolism
D000728:Androgens; D013739:Testosterone