Rapid development of band keratopathy of corneal graft associated with treatment with intracameral recombinant tissue plasminogen activator for postoperative fibrin reaction.
OBJECTIVE
To report a corneal transplant complication associated with intracameral recombinant tissue plasminogen activator (rTPA) treatment of postoperative fibrin reaction.


METHODS
In a 71-year-old patient, a triple procedure was performed for perforated rheumatic ulcer and secondary cataract.


RESULTS
A dense band keratopathy developed rapidly within 36 hours after the use of intracameral injection of rTPA for the treatment of a dense fibrin clot.


CONCLUSIONS
This is the first report of rapid development of massive band keratopathy in a corneal graft after triple procedure and treatment with intracameral rTPA. Intracameral rTPA should be used with caution in patients with attenuated endothelium.
Spitzer
M S
MS
Department of Ophthalmology I, University of Tübingen, Tubingen, Germany. martin.spitzer@med.uni-tuebingen.de
Szurman
P
P
Aisenbrey
S
S
Rohrbach
J M
JM
D000368:Aged; D002114:Calcinosis / Q000139:chemically induced* / Q000175:diagnosis; D002387:Cataract Extraction; D003316:Corneal Diseases / Q000139:chemically induced* / Q000175:diagnosis; D003320:Corneal Ulcer / Q000601:surgery; D005337:Fibrin / Q000187:drug effects*; D005343:Fibrinolytic Agents / Q000009:adverse effects*; D006801:Humans; D015948:Keratoplasty, Penetrating; D008297:Male; D011183:Postoperative Complications; D011994:Recombinant Proteins / Q000009:adverse effects; D010959:Tissue Plasminogen Activator / Q000009:adverse effects*
D005343:Fibrinolytic Agents; D011994:Recombinant Proteins; D005337:Fibrin; D010959:Tissue Plasminogen Activator