title: Nickel sulfate induces numerous defects in Caenorhabditis elegans that can also be transferred to progeny.
abstract: Whether the multiple biological toxicities from nickel exposure could be transferred to progeny has not been clarified. In this report, we explored the Caenorhabditis elegans to analyze the multiple toxicities of nickel and their possibly transferable properties. The nickel toxicity caused multiple biological defects in a concentration-dependent manner. Moreover, most of these toxicities could be transferred and could be only partially rescued in progeny. Some specific phenotypes in progeny were also found to exhibit no obvious rescue phenotypes or to show even more severe defects than their parents. The defects caused by nickel exposure could be classified into four groups according to their transferring properties. That is, the defects caused by nickel exposure could be largely, or partially, or unable to be rescued, or became even more severe in progeny animals. Therefore, most of the nickel exposure-caused defects can be transferred from parents to their progeny to different degrees in C. elegans.
authors.affiliation: Department of Genetics and Developmental Biology, Southeast University, Nanjing, China. dayongw@seu.edu.cn
authors.forename: Dayong
authors.initials: D
authors.lastname: Wang
authors.forename: Yang
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D017173:Caenorhabditis elegans / Q000187:drug effects* / Q000235:genetics; D004305:Dose-Response Relationship, Drug; D004785:Environmental Pollutants / Q000633:toxicity*; D017238:Genes, Helminth; D009532:Nickel / Q000633:toxicity*; D010641:Phenotype; D012098:Reproduction / Q000187:drug effects / Q000235:genetics; D013723:Teratogens / Q000633:toxicity*; D018675:Toxicity Tests
chemical_list: D004785:Environmental Pollutants; D013723:Teratogens; C029938:nickel sulfate; D009532:Nickel