title: Hydrolytic cleavage of DNA by a ruthenium(II) polypyridyl complex.
abstract: The complex [Ru(bpy)2(BPG)]Cl2 (1) containing hydrogen-bond donor (N-H atoms) and acceptor (O atoms) groups mediates hydrolytic cleavage of plasmid pBR322 DNA in an enzyme-like manner. The kinetic aspects of DNA cleavage under pseudo- and true-Michaelis-Menten conditions are detailed.
authors.affiliation: Department of Chemistry, University of Pune, Pune- 411 007, India.
authors.forename: Megha S
authors.initials: MS
authors.lastname: Deshpande
authors.forename: Anupa A
authors.initials: AA
authors.lastname: Kumbhar
authors.forename: Avinash S
authors.initials: AS
authors.lastname: Kumbhar
mesh_terms: D004247:DNA / Q000737:chemistry*; D006868:Hydrolysis; D007700:Kinetics; D015394:Molecular Structure; D011725:Pyridines / Q000737:chemistry*; D012428:Ruthenium / Q000737:chemistry*
chemical_list: D011725:Pyridines; D012428:Ruthenium; D004247:DNA; C023666:pyridine