Cytotoxic alpha-pyrones from Xylaria hypoxylon.
Two new alpha-pyrone derivatives, xylarone (1) and 8,9-dehydroxylarone (2) possessing cytotoxic activities, were isolated from the culture fluid of submerged cultures of the ascomycete Xylaria hypoxylon, strain A27-94. Their structures were elucidated by spectroscopic methods.
Schüffler
Anja
A
Institute of Biotechnology and Drug Research, Erwin-Schrödinger-Str. 56, D-67663 Kaiserslautern, Germany.
Sterner
Olov
O
Anke
Heidrun
H
D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D007939:Leukemia L1210 / Q000473:pathology; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D011753:Pyrones / Q000737:chemistry / Q000302:isolation & purification* / Q000633:toxicity*; D013055:Spectrophotometry, Infrared; D013098:Xylariales / Q000737:chemistry*
D011753:Pyrones