The hard cell: from proteomics to a whole cell model.
Proteomics has provided a wealth of data related to the nature of the proteome, including subcellular location, copy number, interaction partners and protein complexes. This raises the question of whether it is feasible to combine these data, together with other data related to overall cellular structure, to construct a static picture of the cell. In this minireview, we discuss these data, and the issues of turning them into whole cell models.
Betts
Matthew J
MJ
Structural and Computational Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany.
Russell
Robert B
RB
D002477:Cells / Q000378:metabolism*; D023281:Genomics; D006801:Humans; D008954:Models, Biological; D046912:Multiprotein Complexes; D040901:Proteomics; D020798:Two-Hybrid System Techniques
D046912:Multiprotein Complexes