title: Inflammatory lesions of the lung, submandibular gland, bile duct and prostate in a patient with IgG4-associated multifocal systemic fibrosclerosis.
abstract: Multifocal systemic fibrosclerosis (MSF) is a multisystem disease, which often mimics malignancy. A 70-year-old asymptomatic man with lesions in the lung, prostate, submandibular glands and bile ducts appeared to have malignancy. Biopsy of a lung nodule showed IgG4-positive plasma cell infiltration and the serum IgG4 was elevated. A diagnosis of MSF was made and the patient treated with oral prednisolone at 1 mg/kg/day. Sclerosing cholangitis, retroperitoneal fibrosis, Riedel's thyroiditis, fibrotic pseudotumor of the orbit and fibrosis of the salivary glands have all been reported to be part of this disease. It is now necessary for MSF to be considered in patients with pulmonary lesions mimicking lung cancer.
authors.affiliation: First Department of Internal Medicine, Shinsu University School of Medicine, Asahi Matsumoto, Japan.
authors.forename: Ghullam
authors.initials: G
authors.lastname: Hamed
authors.forename: Kenji
authors.initials: K
authors.lastname: Tsushima
authors.forename: Masanori
authors.initials: M
authors.lastname: Yasuo
authors.forename: Keishi
authors.initials: K
authors.lastname: Kubo
authors.forename: Seiichi
authors.initials: S
authors.lastname: Yamazaki
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Kawa
authors.forename: Hideaki
authors.initials: H
authors.lastname: Hamano
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yamamoto
mesh_terms: D000368:Aged; D001652:Bile Ducts / Q000473:pathology*; D001706:Biopsy; D003937:Diagnosis, Differential; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D008168:Lung / Q000276:immunology / Q000473:pathology*; D008175:Lung Neoplasms / Q000175:diagnosis / Q000473:pathology; D008297:Male; D010950:Plasma Cells / Q000276:immunology; D011467:Prostate / Q000473:pathology*; D012595:Scleroderma, Systemic / Q000097:blood / Q000175:diagnosis / Q000276:immunology* / Q000473:pathology*; D013363:Submandibular Gland / Q000473:pathology*
chemical_list: D007074:Immunoglobulin G