HLA typing in Vogt-Koyanagi-Harada syndrome in North Indian patients.
OBJECTIVE
To report the HLA profile of VKH patients from India.


METHODS
Forty-one patients and 50 controls were studied. Phenotyping using a lymphocytotoxicity assay was done for HLA-A and -B. DNA-based sequence-specific low resolution typing was done for HLA-DR and -DQ loci.


RESULTS
HLA-A9 was over-represented in the patient population (p = 0.01), whereas HLA-A11 (p = 0.03) and HLA-DRB1*13 (p = 0.007) were found to be underrepresented. The frequency of HLA-DRB1*04 was 14.6% and 10% in the patient population and controls, respectively. The HLA-DQ frequencies did not differ significantly between patients and controls.


CONCLUSIONS
Unlike that reported in most populations, we did not find a significant association between HLA-DRB1*04 and our patient population.
Gupta
Amod
A
Department of Ophthalmology, Post Graduate Institute of Medical Education and Research, Chandigarh, India. eyepgi@sify.com
Kamal
Shivali
S
Gupta
Vishali
V
Bambery
Pradeep
P
Kaura
Babita
B
D000293:Adolescent; D000328:Adult; D000483:Alleles; D004247:DNA / Q000032:analysis; D016172:DNA Fingerprinting; D005260:Female; D005500:Follow-Up Studies; D005787:Gene Frequency; D015234:HLA-A Antigens / Q000235:genetics / Q000276:immunology*; D059870:HLA-A11 Antigen; D006683:HLA-DQ Antigens / Q000235:genetics / Q000276:immunology*; D006684:HLA-DR Antigens / Q000235:genetics / Q000276:immunology*; D059811:HLA-DRB1 Chains; D006650:Histocompatibility Testing; D006801:Humans; D007194:India / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016036:Seroepidemiologic Studies; D014607:Uveomeningoencephalitic Syndrome / Q000453:epidemiology* / Q000276:immunology*
D015234:HLA-A Antigens; D059870:HLA-A11 Antigen; C037709:HLA-A9 antigen; D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; D004247:DNA