[Discoidin domain receptors (DDRs) expression in pathological scar fibroblast formation].
OBJECTIVE
To explore the role of discoidin domain receptors (DDRs) in the formation of the keloid.


METHODS
The real-time quantitative PCR was used to compare the DDRs expression in the keloids and normal fibroblasts.


RESULTS
The level of DDR1 expression was significantly higher in keloid than in normal fibroblast (20.98 vs 4.2, P <0.01; 7.9 vs 4.23, P <0.05). The level of DDR1 expression in keloid was also higher significantly than that in hypertropic scar (20.98 vs 7.9, P < 0.01). However, the level of DDR2 expression was somewhat higher in keloid than in normal fibroblasts, the difference seemed not to be significantly in probability (358, 332 vs 278, P > 0.05).


CONCLUSIONS
DDRs may exert effect on keloid cell behaviours.
Jiang
Yu-Zhi
YZ
Department of Plastic Surgery, Changhai Hospital, Shanghai 200433, China.
Xing
Xin
X
Wen
Jun-Hui
JH
Xue
Chun-Yu
CY
Zhang
Jing-De
JD
Zhang
Ming-li
ML
D049109:Cell Proliferation; D002478:Cells, Cultured; D002921:Cicatrix / Q000378:metabolism* / Q000473:pathology*; D000070818:Discoidin Domain Receptors; D005260:Female; D005347:Fibroblasts / Q000378:metabolism*; D006801:Humans; D008297:Male; D020794:Receptor Protein-Tyrosine Kinases / Q000378:metabolism*; D011975:Receptors, Mitogen / Q000378:metabolism*
D011975:Receptors, Mitogen; D000070818:Discoidin Domain Receptors; D020794:Receptor Protein-Tyrosine Kinases