title: [Re-osseointegration of peri-implantitis bone defects: an experimental study in dogs].
abstract: OBJECTIVE
  To investigate the treatment methods of experimentally induced peri-implantitis bone defects, and evaluate bone regeneration and re-osseointegration around implants histologically.
  
  
  METHODS
  30 Brinemark standard implants were placed in 5 Beagle dogs' mandibles to establish peri-implantitis bone defect model, then bone defects were randomly treated with: (1) debridement alone; (2) debridement plus guided bone regeneration using non-absorbable membrane; (3) debridement plus non-absorbable membrane associated with bone graft; (4) debridement plus non-absorbable membrane associated with biological activity glass. Peri-implant bone augmentation was observed and detected by radiography, fluorescence light micrography, un-decalcified bones ground section and direct measurement on operation. SPSS 12.0 software package was used for ANOVA, Kruskal-Wallis test and Mann-Whiteney test.
  
  
  RESULTS
  There were significant differences between four groups in peri-implant bone augmentation, bone contact level and bone mineralization apposition rate, P < 0.05. The group using debridement plus non-absorbable membrane associated with bone graft resulted in a greater amount of regeneration than the other treatments.
  
  
  CONCLUSIONS
  Inflammation induced peri-implant bone defects can regenerate by appropriate treatment. Supported by Shanghai Municipal Science and Technology Enhancement Award (Grant No.024119072).
authors.affiliation: Department of Stomatology, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai 200233, China. drzou@citiz.net
authors.forename: De-rong
authors.initials: DR
authors.lastname: Zou
authors.forename: Hong
authors.initials: H
authors.lastname: Zhu
authors.forename: Xiao-hui
authors.initials: XH
authors.lastname: Qu
mesh_terms: D000818:Animals; D001861:Bone Regeneration; D016025:Bone Transplantation; D003646:Debridement; D003758:Dental Implantation, Endosseous / Q000009:adverse effects*; D015921:Dental Implants; D004285:Dogs; D016557:Guided Tissue Regeneration, Periodontal; D008334:Mandible; D016348:Osseointegration; D057873:Peri-Implantitis; D010518:Periodontitis
chemical_list: D015921:Dental Implants