BK virus associated meningoencephalitis in an AIDS patient treated with HAART.
A severely immune-suppressed AIDS patient was suspected of suffering from BK virus (BKV) meningoencephalitis, after being studied for common causes of neurological complications of co-infectious origin. Polymerase chain reaction (PCR) and sequence analysis of cerebrospinal fluid and brain samples, confirmed the presence of BKV. His clinical condition improved along with the regression of brain lesions, after modifications on his antiretroviral regime. Five months after discharge, the patient was readmitted because of frequent headaches, and a marked inflammatory reaction was evidenced by a new magnetic resonance imaging (MRI). The symptoms paralleled a rising CD4+ lymphocyte count, and immune reconstitution syndrome was suspected. This is the first non-postmortem report of BKV meningoencephalitis in an AIDS patient, showing clinical and radiographic improvement solely under HAART.
Vidal
José E
JE
Department of Infectious Diseases, Emilio Ribas Institute of Infectious Diseases, São Paulo, Brazil. josevibe@gmail.com
Fink
Maria C
MC
Cedeno-Laurent
Filiberto
F
Delbue
Serena
S
Ferrante
Pasquale
P
Dauar
Rafi F
RF
Filho
Francisco Bonasser
FB
Nogueira
Roberta Schiavon
RS
Calore
Eduardo E
EE
Pannuti
Claudio S
CS
Trujillo
J Roberto
JR
de Oliveira
Augusto C Penalva
AC