Tying SUMO modifications to dynamic behaviors of chromosomes during meiotic prophase of Saccharomyces cerevisiae.
In budding yeast Saccharomyces cerevisiae, centromeres and telomeres are tethered to the nuclear envelope during premeiotic interphase. Immediately after cells enter meiotic prophase, chromosomes undergo global reorganization, including bouquet formation (telomere clustering), non-homologous centromere coupling, homologous pairing, and assembly/disassembly of synaptonemal complexes. These chromosome dynamics have been implicated in promoting pairing, synapsis, crossover DNA recombination and segregation between homologous chromosomes. This review discusses recent studies related to the role of small ubiquitin-like modifier (SUMO) modification in controlling the overall budding yeast chromosome dynamics during meiotic prophase.
Cheng
Chun-Hsu
CH
Institute of Biological Chemistry, Academia Sinica, Taipei, 115, Taiwan.
Lin
Feng-Ming
FM
Lo
Yu-Hui
YH
Wang
Ting-Fang
TF
D001665:Binding Sites; D015825:Chromosomes, Fungal / Q000502:physiology*; D008540:Meiosis; D008954:Models, Biological; D009687:Nuclear Proteins; D011418:Prophase; D012097:Repressor Proteins / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000235:genetics* / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism; D025841:Small Ubiquitin-Related Modifier Proteins / Q000378:metabolism*; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism
D009687:Nuclear Proteins; D012097:Repressor Proteins; C099362:SMT3 protein, S cerevisiae; D029701:Saccharomyces cerevisiae Proteins; D025841:Small Ubiquitin-Related Modifier Proteins; C090118:Zip1 protein, S cerevisiae; D044767:Ubiquitin-Protein Ligases; C523917:Zip3 protein, S cerevisiae