Characterization of divergent and atypical canine coronaviruses from Sweden.
Field canine coronaviruses (CCVs) identified during a series of outbreaks of gastroenteritis in Swedish dogs were subjected to genetic analysis involving the open reading frame 1b (ORF1b) and the membrane (M) and spike (S) protein genes. Four field viruses originating from the Stockholm region presented identical sequences and segregated separately from other CCVs characterized so far and from GOT/05, the variant recovered in Western Sweden. A recombinant origin of the fifth virus identified in the Stockholm region is suggested. In addition, the five viruses originating from the same geographical area displayed atypical 5' S gene sequences.
Escutenaire
S
S
Department of Virology, National Veterinary Institute (SVA), Uppsala, Sweden. sophie.escutenaire@hotmail.com
Isaksson
M
M
Renström
L H M
LH
Klingeborn
B
B
Buonavoglia
C
C
Berg
M
M
Belák
S
S
Thorén
P
P
D000595:Amino Acid Sequence; D000818:Animals; D018352:Coronavirus Infections / Q000453:epidemiology / Q000662:veterinary / Q000821:virology; D000086862:Coronavirus M Proteins; D017939:Coronavirus, Canine / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D004196:Disease Outbreaks; D004283:Dog Diseases / Q000453:epidemiology* / Q000821:virology; D004285:Dogs; D005759:Gastroenteritis / Q000453:epidemiology / Q000662:veterinary* / Q000821:virology; D014644:Genetic Variation; D008562:Membrane Glycoproteins / Q000235:genetics; D008969:Molecular Sequence Data; D016366:Open Reading Frames / Q000235:genetics; D010802:Phylogeny; D017422:Sequence Analysis, DNA; D064370:Spike Glycoprotein, Coronavirus; D013548:Sweden / Q000453:epidemiology; D014759:Viral Envelope Proteins / Q000235:genetics; D014763:Viral Matrix Proteins / Q000737:chemistry / Q000235:genetics
D000086862:Coronavirus M Proteins; D008562:Membrane Glycoproteins; D064370:Spike Glycoprotein, Coronavirus; D014759:Viral Envelope Proteins; D014763:Viral Matrix Proteins; C578557:spike glycoprotein, SARS-CoV; C578553:spike protein, mouse hepatitis virus