[BTEB/KLF9 and its transcriptional regulation].
BTEB/KLF9(basic transcription element-binding protein/Krüppel-like transcription factor 9), a member of Krüppel-like transcriptional factors, is a zinc finger protein involved in regulating gene transcription in eukaryocyte. Substantial expression of BTEB mRNA is detected in a variety of cell lines and tissues, but BTEB protein is not consistent with its mRNA. BTEB regulates transcription through its carboxyl-terminal C2H2 zinc finger motif binding to GC or GT/CACC box, a sort of cis-acting elements, which is wildly distributed in promoters, enhancers and control regions of many genes. BTEB/KLF9 functions as a transcription factor by direct or functional interaction with other transcription factors and/or coactivators/corepressors, and plays a role in reproductive system, cell proliferation, differentiation, and cell cycle regula-tion.
Kang
Ling
L
Department of Pathology &Pathophysiology, School of Medicine, Zhejiang University, Hangzhou 310058, China. lingkang1220@yahoo.com.cn
Lai
Mao-De
MD
D000595:Amino Acid Sequence; D000818:Animals; D002468:Cell Physiological Phenomena; D005786:Gene Expression Regulation; D006801:Humans; D051741:Kruppel-Like Transcription Factors / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D008969:Molecular Sequence Data; D012098:Reproduction; D015398:Signal Transduction; D014158:Transcription, Genetic
D051741:Kruppel-Like Transcription Factors