title: Matrix metalloproteinase-9 and tissue inhibitors of metalloproteinases 1 in influenza-associated encephalopathy.
abstract: Matrix metalloproteinase-9 (MMP-9) and tissue inhibitors of metalloproteinases 1 (TIMP-1) play important roles in the function of the blood-brain barrier. Serum MMP-9 and TIMP-1 concentrations were determined in influenza virus infection with or without neurologic complications. Our results suggest that an imbalance between MMP-9 and TIMP-1 damages the blood-brain barrier and promotes febrile seizure or encephalopathy in influenza virus infection.
authors.affiliation: Department of Pediatrics, Yamaguchi University School of Medicine, Yamaguchi, Japan. ichiyama@yamaguchi-u.ac.jp
authors.forename: Takashi
authors.initials: T
authors.lastname: Ichiyama
authors.forename: Tsuneo
authors.initials: T
authors.lastname: Morishima
authors.forename: Madoka
authors.initials: M
authors.lastname: Kajimoto
authors.forename: Takeshi
authors.initials: T
authors.lastname: Matsushige
authors.forename: Tomoyo
authors.initials: T
authors.lastname: Matsubara
authors.forename: Susumu
authors.initials: S
authors.lastname: Furukawa
mesh_terms: D000293:Adolescent; D001812:Blood-Brain Barrier / Q000502:physiology; D002648:Child; D002675:Child, Preschool; D018792:Encephalitis, Viral / Q000201:enzymology* / Q000473:pathology; D005260:Female; D006801:Humans; D007223:Infant; D007251:Influenza, Human / Q000150:complications / Q000201:enzymology*; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000097:blood*; D003294:Seizures, Febrile; D019715:Tissue Inhibitor of Metalloproteinase-1 / Q000097:blood*
chemical_list: D019715:Tissue Inhibitor of Metalloproteinase-1; D020780:Matrix Metalloproteinase 9