title: Local cytomegalovirus infection in patients with diarrhea following allogeneic stem cell transplantation.
abstract: To evaluate local cytomegalovirus (CMV) infection in patients who developed diarrhea after allogeneic hematopoietic stem cell transplantation (HSCT), histologic and molecular analysis was carried out with intestinal biopsy samples. from 17 transplant recipients. A CMV-specific intranuclear inclusion body indicating intestinal CMV disease was documented in 2 biopsy samples. CMV DNA was detected by quantitative polymerase chain reaction in 8 of 23 (34.8%) samples, including 2 samples diagnosed with intestinal CMV disease. Of 15 patients without histologic confirmation of intestinal CMV disease, pre-emptive therapy was carried out for 8 patients based on positive antigenemia, and for 2 patients on positive CMV DNA, respectively. Intestinal CMV disease was successfully treated with antiviral therapy for 2 patients and prevented with pre-emptive therapy based on either positive antigenemia or positive CMV DNA for 10 patients. Endoscopic examinations with histologic and molecular analysis may be important in the early treatment and the prevention of intestinal CMV disease in patients with diarrhea after allogeneic stem cell transplantation.
authors.affiliation: Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors.forename: Ichiro
authors.initials: I
authors.lastname: Ninomiya
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Nakashima
authors.forename: Hisashi
authors.initials: H
authors.lastname: Gondo
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Eto
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Seo
authors.forename: Kanpei
authors.initials: K
authors.lastname: Saijyo
authors.forename: Takashi
authors.initials: T
authors.lastname: Matsuura
authors.forename: Koji
authors.initials: K
authors.lastname: Nagafuji
authors.forename: Takashi
authors.initials: T
authors.lastname: Yao
authors.forename: Mine
authors.initials: M
authors.lastname: Harada
mesh_terms: D000328:Adult; D000368:Aged; D003586:Cytomegalovirus Infections / Q000209:etiology*; D003967:Diarrhea / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D033581:Stem Cell Transplantation; D014184:Transplantation, Homologous