title: [Effect of isoflurane inhalation anesthesia on postoperative pain due to castration of piglets].
abstract: Since April 2006 piglets in Germany can only be castrated without anesthesia in the first 7 days of life. However, a castration is a painful experience even for an animal of this young age. Whether the castration under isoflurane-anesthesia is a reasonable alternative to castration without anesthesia was tested in the following investigation at 206 4 to 6 day old piglets. The serum-cortisol-concentration was chosen as the parameter for the pain caused by castration. A part of the animals was castrated without anesthesia (group II, n = 42) or with anesthesia (group IV, n = 41). Additionally Meloxicam, a non-steroidal anti-inflammatory drug, was applicated to piglets castrated with anesthesia (group V, n = 41). For control another part of the animals were only handled without (group I, n = 41) or with anesthesia (group III, n = 41), but they were not castrated. Cortisol-concentration prior to castration was compared to the concentration 0.5, 1,4 and 24 hours after castration. In addition cortisol was compared between groups at all points of time. Cortisol did rise significantly in castrated animals with animals with or without anesthesia than in animals of the non-castrated control groups. Cortisol after castration was significantly lower in piglets with an application of Meloxicam prior to castration. The pain caused by castration is an explanation for the differences in cortisol-concentration between castrated and not-castrated animals. Regarding those results, we assume that castration with isoflurane-anesthesia does not fulfil the demand for reducing pain after castration compared to castrating piglets without anesthesia.
authors.affiliation: Klinik für Schweine, Ludwig-Maximilians-Universität München.
authors.forename: Cornelia
authors.initials: C
authors.lastname: Schulz
authors.forename: Mathias
authors.initials: M
authors.lastname: Ritzmann
authors.forename: Andreas
authors.initials: A
authors.lastname: Palzer
authors.forename: Karl
authors.initials: K
authors.lastname: Heinritzi
authors.forename: Susanne
authors.initials: S
authors.lastname: Zöls
mesh_terms: D000769:Anesthesia, Inhalation / Q000662:veterinary*; D018685:Anesthetics, Inhalation / Q000008:administration & dosage*; D000818:Animals; D000831:Animals, Newborn / Q000601:surgery; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage; D006234:Handling, Psychological; D006854:Hydrocortisone / Q000097:blood; D007530:Isoflurane / Q000008:administration & dosage*; D008297:Male; D000077239:Meloxicam; D009919:Orchiectomy / Q000009:adverse effects / Q000379:methods / Q000662:veterinary*; D010149:Postoperative Pain / Q000188:drug therapy / Q000517:prevention & control / Q000662:veterinary*; D013552:Swine / Q000601:surgery*; D013843:Thiazines / Q000008:administration & dosage; D013844:Thiazoles / Q000008:administration & dosage; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D018685:Anesthetics, Inhalation; D000894:Anti-Inflammatory Agents, Non-Steroidal; D013843:Thiazines; D013844:Thiazoles; D007530:Isoflurane; D000077239:Meloxicam; D006854:Hydrocortisone