title: Secondary palatal closure in rats in association with relative maternofetal levels of folic acid, vitamin B12, and homocysteine.
abstract: Animal experiments are used in embryological and teratological studies of matters relevant to humans. In gravid rats, a decrease in the levels of folic acid and vitamin B12 was observed in maternal blood and in amniotic fluid. At the time of secondary palatal closure (14th day of pregnancy), the folic acid level of the amniotic fluid was 73% lower than that of the maternal blood. A drop in vitamin B12 in conjunction with an increase in amniotic homocysteine levels is seen as a risk factor for malformation of the palate. The understanding of causes of cleft generation could lead to a prophylactic treatment approach.
authors.affiliation: Institute of Anatomy and Cell Biology, Ernst Moritz Arndt University of Greifswald, F-Loeffler-Strasse 23c, D-17475 Greifswald, Germany. fanghaen@uni-greifswald.de
authors.forename: Jens
authors.initials: J
authors.lastname: Weingärtner
authors.forename: Sergei
authors.initials: S
authors.lastname: Maile
authors.forename: Peter
authors.initials: P
authors.lastname: Proff
authors.forename: Claudia
authors.initials: C
authors.lastname: Reicheneder
authors.forename: Volker
authors.initials: V
authors.lastname: Bienengräber
authors.forename: Jochen
authors.initials: J
authors.lastname: Fanghänel
authors.forename: Tomas
authors.initials: T
authors.lastname: Gedrange
mesh_terms: D000818:Animals; D047108:Embryonic Development; D005260:Female; D005492:Folic Acid / Q000097:blood / Q000378:metabolism*; D006710:Homocysteine / Q000097:blood / Q000378:metabolism*; D008431:Maternal-Fetal Exchange; D010159:Palate / Q000196:embryology*; D011247:Pregnancy; D051381:Rats; D011917:Rats, Inbred Lew; D014805:Vitamin B 12 / Q000097:blood / Q000378:metabolism*
chemical_list: D006710:Homocysteine; D005492:Folic Acid; D014805:Vitamin B 12