title: [Changes of sleep architecture in patients with narcolepsy].
abstract: OBJECTIVE
  To investigate the sleep architectures of patients with narcolepsy.
  
  
  METHODS
  38 drug-naive narcoleptic patients, 25 males and 13 females, aged 21 +/- 6.5, and 44 age-, sex ratio-, and BMI-matched normal persons underwent polysomnography (PSG) and multiple sleep latency test (MSLT) during one night sleep. Conventional visual scoring of the polysomnograms was performed according to the international.
  
  
  RESULTS
  The sleep latency of the patients was 5.6 min, however, 30 patients (79%) complained of fragmented nocturnal sleep and difficulty to fall asleep again. The sleep efficiency of the narcoleptics was 81.7% +/- 12.5%, significantly lower than that of the normal persons (87.1% +/- 7.9%, P = 0.029). The non-rapid eye movement (NREM) I sleep accounted for (21.5 +/- 12.2)% in the patients, a proportion significantly higher than that of the normal persons [(10.3 +/- 6.3)%, P = 0.000]). The AHI of the patients was 0.6 +/- 1.3 times/h, not significantly different from that of the normal persons (0.5 +/- 1.1 times/h). Although the rapid eye movement (REM) period and eye movement density of the narcoleptics were significantly increased, their REM period duration was not significantly different from that of the normal subjects (17.7% +/- 6.9% vs 18.9% +/- 5.5%, P = 0.23), probably due to the interruption of REM sleep by more frequent arousals in narcoleptics. PSG did not show significant periodic leg movements in these 2 groups.
  
  
  CONCLUSIONS
  One of the important symptoms of narcolepsy, night sleep disturbance may contribute to the pathological sleepiness of narcolepsy during daytime.
authors.affiliation: Department of Pulmonary Medicine, People's Hospital, Beijing University, Beijing 100044, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.forename: Yan
authors.initials: Y
authors.lastname: Xu
authors.forename: Xiao-Song
authors.initials: XS
authors.lastname: Dong
authors.forename: Xu
authors.initials: X
authors.lastname: Han
authors.forename: Zhong-Ming
authors.initials: ZM
authors.lastname: He
authors.forename: Yun-Hui
authors.initials: YH
authors.lastname: Lü
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.forename: Quan-Ying
authors.initials: QY
authors.lastname: He
authors.forename: Fang
authors.initials: F
authors.lastname: Han
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D009290:Narcolepsy / Q000503:physiopathology*; D017286:Polysomnography; D012894:Sleep Stages / Q000502:physiology*; D020922:Sleep-Wake Transition Disorders / Q000503:physiopathology*; D011795:Surveys and Questionnaires