title: [Long-term outcome of the adult onset craniopharyngiomas].
abstract: There is few published series dealing on the long-term outcome of the adult-onset craniopharyngiomas. We report the long term clinical, tomodensitometric and MRI data outcome of 35 (23 woman and 12 men) consecutive adult-onset cured for craniopharyngiomas between 1983 and 2002, and followed-up in Rennes University Hospital. The operation was performed via frontopterional approach in 59% and transphenoïdal approach in 41% of cases. Their age at the time of diagnosis was 44.7+/-15.1 years (21-74). The average postoperation follow-up was 7.4+/-7.0 years (0.1-19.1). Recurrence of tumour occurred in 8 patients (25.8%) and a tumor progression in 1 case. The delay of recurrence after initial surgery was 4.1+/-1.3 years (1.4-6.3). Two patients had 5 and 6 years treatment by growth hormone (GH), without tumor recurrence. The observed increase of weight after the surgical cure of craniopharyngiomas concerned 22 patients (63%). The average weight gain was 17.5+/-14.7 kg (1.5-58). In 7 cases (20%) neuropsychological disorders were noted, of which 2 with lost of professional activity. Three patients died. In conclusion the craniopharyngiomas recurrence is frequent and can appear in very prolonged deadlines after the initial surgery.
authors.affiliation: Service d'endocrinologie, hôpital Sud, centre hospitalier et universitaire de Rennes, BP 90347, 35203 Rennes, France.
authors.forename: N M
authors.initials: NM
authors.lastname: Baldé
authors.forename: M M
authors.initials: MM
authors.lastname: Diallo
authors.forename: J-Y
authors.initials: JY
authors.lastname: Poirier
authors.forename: M S
authors.initials: MS
authors.lastname: Sow
authors.forename: G
authors.initials: G
authors.lastname: Brassier
authors.forename: Y
authors.initials: Y
authors.lastname: Lorcy
mesh_terms: D000328:Adult; D000368:Aged; D003397:Craniopharyngioma / Q000601:surgery / Q000628:therapy*; D005260:Female; D005500:Follow-Up Studies; D013006:Growth Hormone / Q000627:therapeutic use; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D001523:Mental Disorders / Q000209:etiology; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D010911:Pituitary Neoplasms / Q000601:surgery / Q000628:therapy*; D016019:Survival Analysis; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D013006:Growth Hormone