[Advances of sustained/controlled release pellets in traditional Chinese medicine].
Pellets are multiple-unit drug delivery system, which have good fluidity, release stability and uniformity. With preparation techniques and excipient materials gradually established, pellets play an important part in the development of sustained/controlled release drug delivery system. The recent advances in pellets including the release mechanism, preparation methods, excipients and the characteristics in vivo for the sustained/controlled release pellets in traditional Chinese medicine (TCM) were reviewed in order to provide the strategies and rational methods for further investigations and applications.
Chen
Li-Hua
LH
Center of Science and Technology, Shanghai University of Treditional Chinese Medicine, Shanghai 201203, China.
Feng
Yi
Y
Xu
De-Sheng
DS
D000818:Animals; D002214:Capsules; D003692:Delayed-Action Preparations / Q000737:chemistry*; D016503:Drug Delivery Systems; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000737:chemistry* / Q000302:isolation & purification; D006801:Humans; D008863:Microspheres; D010946:Plants, Medicinal / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry; D013678:Technology, Pharmaceutical / Q000379:methods*
D002214:Capsules; D003692:Delayed-Action Preparations; D004365:Drugs, Chinese Herbal; D011092:Polyethylene Glycols