title: Etnangien, a macrolide-polyene antibiotic from Sorangium cellulosum that inhibits nucleic acid polymerases.
abstract: Etnangien (1), a new macrolide antibiotic active against Gram-positive bacteria, was isolated from the culture broth of the myxobacterium Sorangium cellulosum, strains So ce750 and So ce1045. Spectroscopic structure elucidation of 1 revealed a complex macrocyclic lactone bearing a modified C21 carboxylic acid side chain. The latter contains two allylic hydroxyl groups and an all-E hexaene unit, which provides the characteristic UV chromophore of 1. Initial studies toward the mechanism of action showed that bacterial and viral nucleic acid polymerases are inhibited by etnangien (1).
authors.affiliation: Research Group Microbial Drugs, Helmholtz Centre for Infection Research (HZI), Inhoffenstrasse 7, 38124 Braunschweig, Germany.
authors.forename: Herbert
authors.initials: H
authors.lastname: Irschik
authors.forename: Dietmar
authors.initials: D
authors.lastname: Schummer
authors.forename: Gerhard
authors.initials: G
authors.lastname: Höfle
authors.forename: Hans
authors.initials: H
authors.lastname: Reichenbach
authors.forename: Heinrich
authors.initials: H
authors.lastname: Steinmetz
authors.forename: Rolf
authors.initials: R
authors.lastname: Jansen
mesh_terms: D004926:Escherichia coli / Q000187:drug effects / Q000201:enzymology; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D009052:Leukemia Virus, Murine / Q000187:drug effects / Q000201:enzymology; D018942:Macrolides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015394:Molecular Structure; D009231:Myxococcales / Q000737:chemistry*; D009713:Nucleotidyltransferases / Q000037:antagonists & inhibitors*; D011090:Polyenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D018942:Macrolides; D011090:Polyenes; C521655:etnangien; D009713:Nucleotidyltransferases