Resolution of acromegalic cardiomyopathy in mild acromegalic physical abnormality after short-term octreotide therapy.
Congestive heart failure developed in a 42-year-old man who had very mild acromegalic features. Echocardiography showed a marked dilatation of the left ventricle and decreased systolic function. Laboratory examinations revealed the elevated levels of growth hormone and insulin-like growth factor-1 and pituitary microadenoma was demonstrated by magnetic resonance imaging. Although the extensive conventional medical treatment was ineffective, short-term addition of somatostatin analog, octreotide, rapidly improved his cardiac function. After discontinuation of octreotide, further improvement was observed with minimal residual diastolic dysfunction. All medical treatment could be stopped after successful trans-sphenoidal surgery. Early diagnosis and effective treatment is important to reverse the acromegalic cardiomyopathy.
Hwang
Myung-Woo
MW
Department of Cardiovascular Medicine, Ijinkai-Takeda General Hospital, 28-1 Ishidamori, Minami-machi, Fushimi-ku, Kyoto, 601-1495, Japan.
Shimatsu
Akira
A
Sasaki
Yoshio
Y
Ayukawa
Hiroyuki
H
Inenaga
Katsura
K
Takeoka
Rei
R
Iwase
Tomoyuki
T
Kawai
Chuichi
C
D000172:Acromegaly / Q000000981:diagnostic imaging / Q000188:drug therapy*; D004452:Echocardiography; D004562:Electrocardiography; D006333:Heart Failure / Q000000981:diagnostic imaging / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015282:Octreotide / Q000627:therapeutic use*; D011859:Radiography
D015282:Octreotide