title: Molecular characterization of the equine herpesvirus 1 strains RacL11 and Kentucky D.
abstract: The pathogenicities of RacL11 and Kentucky D strains of equine herpesvirus 1 in the hamster infection model are different from those of Ab4p and the Japanese isolates. Virus genome restriction fragment length polymorphism analysis and sequence comparison of an intergenic region, glycoproteins and tegument genes showed higher conservation but with some strain-specific differences. These results indicate that point nucleotide differences in RacL11 and Kentucky D might be responsible for their pathogenicity in rodent models.
authors.affiliation: Department of Applied Veterinary Sciences, United Graduate School of Veterinary Sciences, Gifu University, Yanagido, Gifu, Japan.
authors.forename: Yasser M
authors.initials: YM
authors.lastname: Ghanem
authors.forename: El-Sayed M
authors.initials: el-SM
authors.lastname: Ibrahim
authors.forename: Souichi
authors.initials: S
authors.lastname: Yamada
authors.forename: Tomio
authors.initials: T
authors.lastname: Matsumura
authors.forename: Nikolaus
authors.initials: N
authors.lastname: Osterrieder
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Yamaguchi
authors.forename: Hideto
authors.initials: H
authors.lastname: Fukushi
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D017124:Conserved Sequence / Q000235:genetics; D006224:Cricetinae; D005814:Genes, Viral / Q000235:genetics*; D014644:Genetic Variation; D004861:Herpesvirus 1, Equid / Q000235:genetics* / Q000472:pathogenicity; D008969:Molecular Sequence Data; D012150:Polymorphism, Restriction Fragment Length; D017422:Sequence Analysis, DNA; D013045:Species Specificity