title: Carcinoid tumors are 15 times more common in patients with Crohn's disease.
abstract: BACKGROUND
  The coexistence of intestinal neoplasms with Crohn's disease (CD) has been reported, but the evidence of an increased risk of carcinoid tumor with Crohn's disease has been mixed. We present 4 patients with CD with associated carcinoid tumor.
  
  
  METHODS
  The charts of 111 patients with CD who had undergone resection between June 2001 and March 2005 were reviewed. The number of incidental carcinoid tumors in patients who underwent an appendectomy was used as a control.
  
  
  RESULTS
  Four cases of carcinoid tumor discovered in patients at resection for CD were identified. None had metastatic disease or carcinoid syndrome. These included 1 cecal (1 mm), 2 appendiceal (3 and 7 mm), and 1 transverse colon (7 mm) carcinoid tumors. None of the carcinoid tumors were identified in regions of active Crohn's disease. The incidence of carcinoid tumor in patients with Crohn's disease was 4 of 111 (3.6%). In comparison, 3 of 1199 patients (0.25%) who had appendectomies were identified as having appendiceal carcinoid tumor. Crohn's disease was associated with an increased incidence of carcinoid tumor; OR 14.9 (95% CI 2.5-102.5), P<0.0001.
  
  
  CONCLUSIONS
  There was a significantly increased incidence of carcinoid tumor in our Crohn's patients compared to the control patients. None of the carcinoid tumors developed in areas of Crohn's disease. This suggests that the development of carcinoid tumors may be secondary to distant proinflammatory mediators, rather than a local inflammatory effect from adjacent Crohn's disease. Patients with CD may be at increased risk of developing a carcinoid tumor.
authors.affiliation: Inflammatory Bowel Disease Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
authors.forename: N E
authors.initials: NE
authors.lastname: West
authors.forename: P E
authors.initials: PE
authors.lastname: Wise
authors.forename: A J
authors.initials: AJ
authors.lastname: Herline
authors.forename: R L
authors.initials: RL
authors.lastname: Muldoon
authors.forename: W V
authors.initials: WV
authors.lastname: Chopp
authors.forename: D A
authors.initials: DA
authors.lastname: Schwartz
mesh_terms: D000328:Adult; D001062:Appendectomy; D002276:Carcinoid Tumor / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology; D015331:Cohort Studies; D003424:Crohn Disease / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology; D005260:Female; D006801:Humans; D007249:Inflammation; D015212:Inflammatory Bowel Diseases / Q000175:diagnosis; D007414:Intestinal Neoplasms / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D013997:Time Factors