Short and efficient asymmetric synthesis of (-)-alpha-conhydrine.
The short and efficient synthesis of (-)-alpha-conhydrine was accomplished with 41% overall yield in seven steps and high diastereo- and enantioselectivity. The anti-stereochemistry of the two stereogenic centers has been confirmed by the single-crystal X-ray analysis of an intermediate.
Voituriez
Arnaud
A
Université Pierre et Marie Curie-Paris 6, Laboratoire de Chimie Organique (UMR CNRS 7611), Institut de Chimie Moléculaire (FR 2769), case 183, 4 place Jussieu, F-75252 Paris Cedex 05, France.
Ferreira
Franck
F
Chemla
Fabrice
F
D007769:Lactams / Q000138:chemical synthesis / Q000737:chemistry; D015394:Molecular Structure; D010880:Piperidines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D007769:Lactams; D010880:Piperidines; C520251:alpha-conhydrine