Regeneration-based therapies for spinal cord injuries.
Although it has been long believed that the damaged central nervous system does not regenerate upon injury, there is an emerging hope for regeneration-based therapy of the damaged central nervous system (CNS) due to the progress of developmental biology and regenerative medicine including stem cell biology. In this review, we have summarized recent studies aimed at the development of regeneration-based therapeutic approaches for spinal cord injuries, including therapy with anti-inflammatory cytokines, transplantation of neural stem/precursor cells and induction of axonal regeneration.
Okano
Hideyuki
H
Department of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan. hidokano@sc.itc.keio.ac.jp
Kaneko
Shinjiro
S
Okada
Seiji
S
Iwanami
Akio
A
Nakamura
Masaya
M
Toyama
Yoshiaki
Y
D000818:Animals; D016207:Cytokines / Q000494:pharmacology / Q000627:therapeutic use; D006131:Growth Inhibitors / Q000037:antagonists & inhibitors / Q000276:immunology; D006801:Humans; D009187:Myelitis / Q000188:drug therapy* / Q000276:immunology / Q000517:prevention & control; D009416:Nerve Regeneration / Q000502:physiology; D013119:Spinal Cord Injuries / Q000628:therapy*; D033581:Stem Cell Transplantation / Q000379:methods* / Q000639:trends
D016207:Cytokines; D006131:Growth Inhibitors