title: Effect of GB virus C co-infection on response to generic HAART in African patients with HIV-1 clade C infection.
abstract: In 38 African AIDS patients initiating generic HAART, GB virus C (GBV-C) RNA-positive patients retained GBV-C viraemia during 52 weeks of HAART, had a faster decline in HIV viral load (P = 0.03), fewer opportunistic infections (14.3 versus 50%, P = 0.18), and suffered no serious adverse events (none versus 61%, P = 0.008) compared with patients without GBV-C. GBV-C co-infection may be associated with a beneficial effect on African AIDS patients treated with generic HAART.
authors.affiliation: Medical Bioethics Unit, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.
authors.forename: Anisa
authors.initials: A
authors.lastname: Mosam
authors.forename: Mahomed A
authors.initials: MA
authors.lastname: Sathar
authors.forename: Halima
authors.initials: H
authors.lastname: Dawood
authors.forename: Edana
authors.initials: E
authors.lastname: Cassol
authors.forename: Tonya M
authors.initials: TM
authors.lastname: Esterhuizen
authors.forename: Hoosen M
authors.initials: HM
authors.lastname: Coovadia
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000453:epidemiology; D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000453:epidemiology; D000328:Adult; D000349:Africa / Q000453:epidemiology; D023241:Antiretroviral Therapy, Highly Active / Q000379:methods*; D005260:Female; D018178:Flaviviridae Infections / Q000150:complications / Q000453:epidemiology*; D029407:GB virus C; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy* / Q000453:epidemiology; D015497:HIV-1; D006525:Hepatitis, Viral, Human / Q000150:complications / Q000453:epidemiology*; D006566:Herpesviridae Infections / Q000150:complications / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012367:RNA, Viral / Q000032:analysis; D012189:Retrospective Studies; D012514:Sarcoma, Kaposi / Q000150:complications / Q000453:epidemiology; D014766:Viremia / Q000150:complications / Q000453:epidemiology
chemical_list: D012367:RNA, Viral