title: Prevalence of large cavum septi pellucidi and its relation to the medial temporal lobe structures in schizophrenia spectrum.
abstract: Magnetic resonance imaging was used to evaluate the prevalence of the cavum septi pellucidi (CSP) in 154 schizophrenia patients, 47 schizotypal disorder patients, and 163 healthy controls. We also explored the relation of a large CSP (> or =6 mm) with medial temporal lobe structures. No significant difference was found in the prevalence of the CSP (76.0% of the schizophrenia patients, 81.6% of the controls, and 85.1% of the schizotypal patients) or the large CSP (6.5% of the schizophrenia patients, 7.4% of the controls, and 10.6% of the schizotypal patients) among the groups, but patients with a large CSP (10 schizophrenia and 5 schizotypal patients) had smaller volumes of bilateral amygdala and left posterior parahippocampal gyrus than patients without it. In the control subjects, the large CSP did not affect the volumes of the medial temporal lobe structures. These findings might reflect neurodevelopmental abnormalities in midline and associated limbic structures of the brain in schizophrenia spectrum.
authors.affiliation: Department of Neuropsychiatry, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan. tsutomu@med.u-toyama.ac.jp
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Takahashi
authors.forename: Michio
authors.initials: M
authors.lastname: Suzuki
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Hagino
authors.forename: Lisha
authors.initials: L
authors.lastname: Niu
authors.forename: Shi-Yu
authors.initials: SY
authors.lastname: Zhou
authors.forename: Kazue
authors.initials: K
authors.lastname: Nakamura
authors.forename: Ryoichiro
authors.initials: R
authors.lastname: Tanino
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Kawasaki
authors.forename: Hikaru
authors.initials: H
authors.lastname: Seto
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Kurachi
mesh_terms: D000328:Adult; D015331:Cohort Studies; D005260:Female; D007839:Functional Laterality; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D015999:Multivariate Analysis; D015995:Prevalence; D011569:Psychiatric Status Rating Scales / Q000706:statistics & numerical data; D012559:Schizophrenia / Q000453:epidemiology / Q000473:pathology*; D012569:Schizotypal Personality Disorder / Q000453:epidemiology / Q000473:pathology*; D012688:Septum Pellucidum / Q000002:abnormalities* / Q000473:pathology; D013702:Temporal Lobe / Q000473:pathology*