title: Angioimmunoblastic T-cell lymphoma developed with lymphocytic pleural effusion.
abstract: Angioimmunoblastic T-cell lymphoma (AILT) is a rare variant of nodal and aggressive lymphoma. It is sometimes difficult to distinguish AILT from reactive lymphoid hyperplasia from the histopathological aspect. We report a case of AILT which developed with bilateral pleural effusion. The effusion consisted predominately of small lymphoid cells. Analyses of the effusion showed trisomy 3, and rearranged bands of TCR beta gene. Flow cytometry showed a very small amount of CD10-positive cells. Although we could not further identify the tumor cells in this case, analysis of pleural effusion cells will increase our understanding of the pathogenesis and the pathophysiology of AILT.
authors.affiliation: Department of Respiratory Medicine, Katta General Hospital, Shiroishi.
authors.forename: Keisuke
authors.initials: K
authors.lastname: Hosoki
authors.forename: Shinji
authors.initials: S
authors.lastname: Okada
authors.forename: Ryo
authors.initials: R
authors.lastname: Ichinohasama
authors.forename: Masaaki
authors.initials: M
authors.lastname: Yamaguchi
authors.forename: Bine
authors.initials: B
authors.lastname: Uchiyama
authors.forename: Toshihide
authors.initials: T
authors.lastname: Maeyama
mesh_terms: D000369:Aged, 80 and over; D002893:Chromosomes, Human, Pair 3 / Q000235:genetics; D015321:Gene Rearrangement / Q000235:genetics; D019674:Genes, T-Cell Receptor beta / Q000235:genetics; D006801:Humans; D007119:Immunoblastic Lymphadenopathy / Q000150:complications* / Q000175:diagnosis / Q000235:genetics / Q000276:immunology; D016399:Lymphoma, T-Cell / Q000150:complications* / Q000175:diagnosis / Q000235:genetics / Q000276:immunology; D008297:Male; D015260:Neprilysin / Q000378:metabolism; D016066:Pleural Effusion, Malignant / Q000209:etiology* / Q000473:pathology; D014314:Trisomy / Q000235:genetics
chemical_list: D015260:Neprilysin