[The extract of compound Radix Scutellariae on mRNA replication and IFN expression of influenza virus in mice].
OBJECTIVE
To study the extract of compound Radix Scutellariae on inhibiting the mRNA replication and inducing the INF expression of influenza virus in mice's vivo.


METHODS
Influenza virus infected mice pneumono-adaption stock A/FM/1/47 (H1N1) evoked mice pneumonia taken as animal model. RT-PCR was adopted to measure the content of influenza virus's mRNA and INF in mice to study the effect of the extract on mRNA replication and IFN expression.


RESULTS
The extract of compound Radix Scutellariae could inhibit influenza virus' s mRNA replication (P < 0.01) and induce interferon expression in mice (P > 0.05).


CONCLUSIONS
The extract of compound Radix Scutellariae can induce interferon and inhibit influenza virus replication in mice.
Chu
Ming
M
Department of Immunology, School of Basic Medicine, Peking University, Beijing 100083, China. yffl118@sina.com
Chu
Zheng-yun
ZY
Wang
Dan-dan
DD
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D053118:Influenza A Virus, H1N1 Subtype / Q000502:physiology*; D007372:Interferons / Q000096:biosynthesis* / Q000235:genetics; D008297:Male; D051379:Mice; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*; D011024:Pneumonia, Viral / Q000378:metabolism / Q000473:pathology*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction; D031364:Scutellaria baicalensis / Q000737:chemistry*; D014779:Virus Replication / Q000187:drug effects*
D010936:Plant Extracts; D012333:RNA, Messenger; C499814:Scutellaria baicalensis extract; D007372:Interferons