title: Expression of PD-L1, a marker of disease status, is not reduced by HAART in aviraemic patients.
abstract: Anergy and defective immune responses are characteristic of chronic HIV-1 infection. The programmed death 1 (PD-1)/PD-1 ligand (PD-L1) pathway appears to be involved in downregulating T-cell functionality. We found raised levels of PD-L1 in aviraemic chronically infected HIV-1-positive patients, which may contribute to incomplete immune reconstitution after treatment with HAART.
authors.affiliation: Department of Immunology, Imperial College London, Chelsea and Westminster Hospital, London, UK.
authors.forename: Guglielmo
authors.initials: G
authors.lastname: Rosignoli
authors.forename: Alison
authors.initials: A
authors.lastname: Cranage
authors.forename: Catherine
authors.initials: C
authors.lastname: Burton
authors.forename: Mark
authors.initials: M
authors.lastname: Nelson
authors.forename: Alan
authors.initials: A
authors.lastname: Steel
authors.forename: Brian
authors.initials: B
authors.lastname: Gazzard
authors.forename: Frances
authors.initials: F
authors.lastname: Gotch
authors.forename: Nesrina
authors.initials: N
authors.lastname: Imami
mesh_terms: D015703:Antigens, CD / Q000032:analysis*; D023241:Antiretroviral Therapy, Highly Active / Q000379:methods*; D051017:Apoptosis Regulatory Proteins / Q000032:analysis*; D060890:B7-H1 Antigen; D017252:CD3 Complex / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D015658:HIV Infections / Q000188:drug therapy / Q000276:immunology*; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D018655:Lymphocyte Count; D061026:Programmed Cell Death 1 Receptor; D054400:Receptors, CCR7; D019707:Receptors, Chemokine / Q000276:immunology
chemical_list: D015703:Antigens, CD; D051017:Apoptosis Regulatory Proteins; D060890:B7-H1 Antigen; C515370:CCR7 protein, human; C423236:CD274 protein, human; D017252:CD3 Complex; C105992:PDCD1 protein, human; D061026:Programmed Cell Death 1 Receptor; D054400:Receptors, CCR7; D019707:Receptors, Chemokine