title: Spectrophotometric estimation of ambroxol and cetirizine hydrochloride from tablet dosage form.
abstract: Fixed dose combination tablets containing ambroxol HCl and cetirizine HCl are clinically used as mucolytic and antiallergic. Several spectrophotometric and HPLC methods have been reported for simultaneous estimation of these drugs with other drugs. The drugs individually and in mixture obeys Beer's law over conc. range 1.2-4.4 microg/mL for cetirizine HCL and for ambroxol HCL 15-52 microg/mL at all five sampling wavelengths (correlation coeff. well above 0.995). The mean recoveries from tablet by standard addition method were 100.18% (+/-2.4) and 100.66 % (+/-2.31). The present work reports simple, accurate and precise spectrophotometric methods for their simultaneous estimation from tablet dosage form.
authors.affiliation: Department of Pharmaceutics, Maharashtra Institute of Pharmacy, Paud Road, Kothrud, Pune-3.
authors.forename: N M
authors.initials: NM
authors.lastname: Gowekar
authors.forename: V V
authors.initials: VV
authors.lastname: Pande
authors.forename: A V
authors.initials: AV
authors.lastname: Kasture
authors.forename: A R
authors.initials: AR
authors.lastname: Tekade
authors.forename: J G
authors.initials: JG
authors.lastname: Chandorkar
mesh_terms: D000551:Ambroxol / Q000032:analysis*; D018926:Anti-Allergic Agents / Q000032:analysis*; D017332:Cetirizine / Q000032:analysis*; D004338:Drug Combinations; D005100:Expectorants / Q000032:analysis*; D013056:Spectrophotometry, Ultraviolet; D013607:Tablets
chemical_list: D018926:Anti-Allergic Agents; D004338:Drug Combinations; D005100:Expectorants; D013607:Tablets; D000551:Ambroxol; D017332:Cetirizine