title: Biomarker approaches to the development of cancer screening tests: can cancer blood tests become a routine health check-up?
abstract: Cancer is a deadly disease associated with high rates of morbidity and mortality. The vast majority of cancers are identified at a late stage, when therapy is rarely successful Morbidity and mortality associated with cancer can be reduced with improved prevention and early detection activities. Identification of cancer biomarkers is one of the most promising approaches for the detection of early-stage malignant or even premalignant lesions with a simple blood test. A large number of research teams are investigating the role of biomarkers in cancer detection and progression, making the dream of early and painless cancer detection become a reality.
authors.affiliation: Division of Hematology & Oncology, University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, 5117 Centre Avenue, Suite 1.19, Pittsburgh, PA 15213, USA. fyL1@pitt.edu
authors.forename: Faina
authors.initials: F
authors.lastname: Linkov
authors.forename: Zoya
authors.initials: Z
authors.lastname: Yurkovetsky
authors.forename: Anna
authors.initials: A
authors.lastname: Lokshin
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood*; D042241:Early Diagnosis; D006801:Humans; D008403:Mass Screening / Q000379:methods; D009369:Neoplasms / Q000097:blood* / Q000517:prevention & control
chemical_list: D014408:Biomarkers, Tumor