title: Left ventricular apical rupture caused by takotsubo cardiomyopathy--comprehensive pathological heart investigation.
abstract: An 81-year-old woman with emotionally-induced takotsubo cardiomyopathy developed a fatal left ventricular (LV) apical rupture. During the hospitalization persistent ST-segment elevation with no electrocardiographic time evolution was observed on the ECG, characteristic for takotsubo cardiomyopathy. Histopathologically, transmural myocardial necrosis with hemorrhage was found at the rupture site, but there were foci of coagulation and contraction band necrosis with mononuclear lymphocyte infiltrations in other heart regions, and the intensity and distribution of these pathological changes corresponded to the distribution of the LV contraction abnormalities seen on ventriculography. The article concludes that: the LV functional disorder in takotsubo cardiomyopathy may be caused by distracted foci of coagulation and contraction band necrosis in the myocardium; contraction band necrosis (a sign of catecholamine cardiotoxicity) may reflect the sympathetic hyperactivity in this disease; persistent myocardial damage expressed by persistent ST-segment elevation without an electrocardiographic time evolution should be carefully observed with sequential echocardiographic examinations because of the possibility of cardiac rupture.
authors.affiliation: Department of Cardiology, Regional Medical Center in Opole, Al. Witosa 26, 45-418 Opole, Poland. sacha@op.pl
authors.forename: Jerzy
authors.initials: J
authors.lastname: Sacha
authors.forename: Jacek
authors.initials: J
authors.lastname: Maselko
authors.forename: Andrzej
authors.initials: A
authors.lastname: Wester
authors.forename: Zbigniew
authors.initials: Z
authors.lastname: Szudrowicz
authors.forename: Wladyslaw
authors.initials: W
authors.lastname: Pluta
mesh_terms: D000369:Aged, 80 and over; D001777:Blood Coagulation; D004562:Electrocardiography; D005260:Female; D006352:Heart Ventricles / Q000473:pathology* / Q000503:physiopathology; D006470:Hemorrhage / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D008214:Lymphocytes / Q000473:pathology; D009206:Myocardium / Q000473:pathology*; D012422:Rupture, Spontaneous / Q000473:pathology / Q000503:physiopathology; D054549:Takotsubo Cardiomyopathy / Q000473:pathology* / Q000503:physiopathology