The asymmetric vinylogous Mannich reaction of dicyanoalkylidenes with alpha-amido sulfones under phase-transfer conditions.
The stereoselective vinylogous Mannich reaction of dicyanoalkylidenes under phase-transfer catalytic conditions utilizing stable alpha-amido sulfones as imine precursors is presented; a rigid pyrrolidinium salt acts as the phase-transfer catalyst, giving access to the amino alkylated products in generally good yield and up to 95% ee.
Niess
Barbara
B
Danish National Research Foundation: Center for Catalysis, Department of Chemistry, Aarhus University, Aarhus C, DK-8000, Denmark.
Jørgensen
Karl Anker
KA