Heterogeneous accumulation of uranium in the brain of rats.
Recent reports suggest that uranium can accumulate not only in known target organs, that is, kidneys or bones, but also in others such as central nervous system. In the present work, the accumulation of uranium in the brain of rats was studied after repeated exposure by inhalation, chronic exposure by ingestion and acute exposure by injection. For each route of administration, the amount of uranium entering the brain was low. The results showed different accumulation in the brain areas according to the route of intake. Injection gave a rather homogeneous distribution in the different brain areas, whereas both inhalation and ingestion yielded heterogeneous but specific accumulation. These differences in distribution suggest the operation of different mechanisms of delivery of uranium to the brain tissues.
Houpert
Pascale
P
Institut de Radioprotection et de Sûreté Nucléaire, DRPH, SRBE, LRTOX, BP166, 26702 Pierrelatte, France. pascale.houpert@irsn.fr
Frelon
Sandrine
S
Monleau
Marjorie
M
Bussy
Cyrill
C
Chazel
Valérie
V
Paquet
François
F
D000818:Animals; D001921:Brain / Q000378:metabolism*; D008297:Male; D008657:Metabolic Clearance Rate; D009928:Organ Specificity; D011829:Radiation Dosage; D011874:Radiometry / Q000379:methods*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012062:Relative Biological Effectiveness; D014501:Uranium / Q000032:analysis / Q000493:pharmacokinetics*
D014501:Uranium