title: [Recurrence of differentiated thyroid carcinoma without concomitant elevation of serum thyroglobulin: report of two cases].
abstract: Thyroid carcinoma is the most prevalent endocrine tumor, and the papillary carcinoma (PC) is the most common histological type. In the follow-up, after thyroidectomy serum thyroglobulin (s-Tg) is used as a marker to evaluate recurrence of thyroid carcinoma. In most cases, this parameter allows an adequate diagnosis, but occasionally s-Tg may miss the detection of a recurrence. We report a 57 year-old female and a 36 year-old male subjected to a total thyroidectomy for a papillary thyroid carcinoma with intermediate and high-risk of recurrence. Both had a cervical recurrence without a concomitant increase in s-Tg levels. In both, Tg staining was positive in the tumor cells. These cases confirm that in these patients, the follow-up must be done with measurement of s-Tg and complementary diagnostic tests.
authors.affiliation: Departamento de Endocrinología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
authors.forename: Soledad
authors.initials: S
authors.lastname: Velasco
authors.forename: Antonieta
authors.initials: A
authors.lastname: Solar
authors.forename: Francisco
authors.initials: F
authors.lastname: Cruz
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Quintana
authors.forename: Augusto
authors.initials: A
authors.lastname: León
authors.forename: Lorena
authors.initials: L
authors.lastname: Mosso
authors.forename: Carlos
authors.initials: C
authors.lastname: Fardella
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000097:blood*; D001706:Biopsy; D002291:Carcinoma, Papillary / Q000097:blood* / Q000556:secondary / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000097:blood* / Q000175:diagnosis / Q000601:surgery; D013954:Thyroglobulin / Q000097:blood*; D013964:Thyroid Neoplasms / Q000097:blood* / Q000473:pathology / Q000601:surgery
chemical_list: D014408:Biomarkers, Tumor; D013954:Thyroglobulin