title: Activation of neutrophils by a novel triggering immunoglobulin-like receptor MAIR-IV.
abstract: Neutrophils play a central role in host defenses against infectious microbial pathogens. However, molecular basis for their triggering signals has been incompletely understood. Here, we show molecular and functional characteristics of myeloid-associated immunoglobulin-like receptor (MAIR)-IV. MAIR-IV was preferentially expressed on neutrophils in the peripheral blood, bone marrow, peritoneal cavity and spleen. MAIR-IV physically associates with immunoreceptor tyrosine based activating motif (ITAM)-bearing adaptor FcRgamma chain. Cross-linking MAIR-IV with anti-MAIR-IV monoclonal antibody significantly induced secretion of proinflammatory cytokines TNF-alpha and IL-6 from neutrophils. Thus, MAIR-IV may regulate activation of neutrophils and play an important role for innate immunity.
authors.affiliation: Department of Immunology, Institute of Basic Medical Sciences and Center for TARA, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki 305-8575, Japan.
authors.forename: Takako
authors.initials: T
authors.lastname: Nakano
authors.forename: Satoko
authors.initials: S
authors.lastname: Tahara-Hanaoka
authors.forename: Chigusa
authors.initials: C
authors.lastname: Nakahashi
authors.forename: Ismail
authors.initials: I
authors.lastname: Can
authors.forename: Naoya
authors.initials: N
authors.lastname: Totsuka
authors.forename: Shin-ichiro
authors.initials: S
authors.lastname: Honda
authors.forename: Kazuko
authors.initials: K
authors.lastname: Shibuya
authors.forename: Akira
authors.initials: A
authors.lastname: Shibuya
mesh_terms: D000818:Animals; D033481:Chromosomes, Mammalian; D016207:Cytokines / Q000378:metabolism; D006801:Humans; D008264:Macrophages / Q000378:metabolism; D051379:Mice; D018375:Neutrophil Activation / Q000276:immunology*; D009504:Neutrophils / Q000378:metabolism; D011485:Protein Binding; D017452:Receptors, IgG / Q000276:immunology; D019056:Receptors, Polymeric Immunoglobulin / Q000276:immunology*
chemical_list: D016207:Cytokines; C524158:MAIR-IV protein, mouse; D017452:Receptors, IgG; D019056:Receptors, Polymeric Immunoglobulin