title: Evaluation of microalbuminuria after non-ionic radiocontrast medium exposure in patients undergoing coronary angiography.
abstract: Transient and massive glomerular proteinuria, previously reported as one of the nephrotoxic reactions after ionic radiocontrast medium (RCM) exposure, is rarely observed in patients since the introduction of non-ionic RCM. However, whether the very low-range microalbuminuria might be encountered after non-ionic RCM exposure remains unknown. In this study we sought to investigate the effects of non-ionic RCM (Ultravist 370) exposure on the presence of microalbuminuria, defined as urine albumin-to-creatinine ratio (UACR) >30 mg/g, by a turbidmetric method in total of 64 patients (17 female, mean age 58+/-12 years) undergoing coronary angiography. The results showed that after non-ionic RCM (mean volume 103+/-57 ml) exposure, no significant differences were found in urinary albumin concentration or UACR; however, urinary creatinine was significantly reduced from 116+/-62 to 69+/-43 mg/dl (p<0.001). Changes in the presence of microalbuminuria before and after procedure were also not significant (p=0.891, McNemar test). In conclusion, non-ionic RCM exposure during CAG had negligible effect on the excretion of urinary albumin even within the detection range of microalbuminuria.
authors.forename: Kai-Hong
authors.initials: KH
authors.lastname: Cheng
authors.forename: Chih-Sheng
authors.initials: CS
authors.lastname: Chu
authors.forename: Kun-Tai
authors.initials: KT
authors.lastname: Lee
authors.forename: Tsung-Hsien
authors.initials: TH
authors.lastname: Lin
authors.forename: Wen-Chol
authors.initials: WC
authors.lastname: Voon
authors.forename: Li-Yu
authors.initials: LY
authors.lastname: Tsai
authors.forename: Sheng-Hsiung
authors.initials: SH
authors.lastname: Sheu
authors.forename: Wen-Ter
authors.initials: WT
authors.lastname: Lai
mesh_terms: D000419:Albuminuria / Q000139:chemically induced*; D003287:Contrast Media / Q000009:adverse effects*; D017023:Coronary Angiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018709:Statistics, Nonparametric
chemical_list: D003287:Contrast Media