t(8;14;18): a 3-way chromosome translocation in two patients with Burkitt's lymphoma/leukemia.
Burkitt's lymphoma (BL) is a heterogeneous group of highly aggressive mature B-cell malignancies. It is characterized by a high rate of turnover of malignant cells and deregulation of the c-myc gene. It is typically associated with a t(8;14) translocation. Dual translocation of t(8;14) (c-myc) and t(14;18) (bcl-2) was reported to be associated with extremely poor prognosis. This study reports a novel t(8;14;18) triple translocation in two patients with Burkitt's lymphoma.
Liu
Delong
D
Division of Oncology/Hematology, New York Medical College and Westchester Medical Center, Valhalla, NY 10595, USA. delong_liu@nymc.edu
Shimonov
Josif
J
Primanneni
Suneeta
S
Lai
Yongrong
Y
Ahmed
Tauseef
T
Seiter
Karen
K
D002051:Burkitt Lymphoma / Q000188:drug therapy / Q000235:genetics* / Q000532:radiotherapy; D002883:Chromosomes, Human, Pair 14 / Q000235:genetics / Q000648:ultrastructure*; D002887:Chromosomes, Human, Pair 18 / Q000235:genetics / Q000648:ultrastructure*; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics / Q000648:ultrastructure*; D003131:Combined Modality Therapy; D005260:Female; D005803:Genes, Immunoglobulin; D019254:Genes, bcl-2; D016259:Genes, myc; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D012074:Remission Induction; D014178:Translocation, Genetic
D007143:Immunoglobulin Heavy Chains