title: Biomechanical assessment of radial optic neurotomy.
abstract: OBJECTIVE
  A biomechanical model was constructed to simulate the potential therapeutic effect that the surgical procedure radial optic neurotomy (RON) would have on an eye with a central retinal vein occlusion.
  
  
  METHODS
  Experimental study.
  
  
  METHODS
  Model eyes undergoing RON were compared to control eyes under the same baseline conditions.
  
  
  METHODS
  Radial optic neurotomy. We modeled the optic nerve, lamina cribrosa, and the sclera separately and then reassembled the components. Material properties of the sclera and lamina cribrosa were extracted from the literature and both stiff and more elastic values were used for the optic nerve. Intraocular and arterial pressures were varied across a wide range in the analysis.
  
  
  METHODS
  Change in central retinal vein lumen size.
  
  
  RESULTS
  Over a clinically relevant range of boundary conditions, the increase in the lumen area of the central retinal vein lumen after RON remained trivial, ranging from 1% to a maximum of 5%.
  
  
  CONCLUSIONS
  The biomechanical effect of RON is negligible, and is unlikely to be a procedure that could mechanically ameliorate the clinical sequelae of a central vein occlusion.
authors.affiliation: Department of Ophthalmology, University of Pittsburgh School of Medicine, UPMC Eye Center, Pittsburgh, Pennsylvania 15213, USA. friberg@pitt.edu
authors.forename: Thomas R
authors.initials: TR
authors.lastname: Friberg
authors.forename: Patrick
authors.initials: P
authors.lastname: Smolinski
authors.forename: Sarajane
authors.initials: S
authors.lastname: Hill
authors.forename: Shree K
authors.initials: SK
authors.lastname: Kurup
mesh_terms: D001696:Biomechanical Phenomena; D003198:Computer Simulation; D019299:Decompression, Surgical / Q000379:methods*; D004547:Elastic Tissue; D020342:Finite Element Analysis; D006801:Humans; D007429:Intraocular Pressure; D008954:Models, Biological; D013508:Ophthalmologic Surgical Procedures; D009898:Optic Disk / Q000098:blood supply* / Q000601:surgery; D009900:Optic Nerve / Q000503:physiopathology / Q000601:surgery*; D012169:Retinal Vein / Q000503:physiopathology / Q000601:surgery*; D012170:Retinal Vein Occlusion / Q000503:physiopathology / Q000601:surgery*