Characterization of NcsB2 as a promiscuous naphthoic acid/coenzyme A ligase integral to the biosynthesis of the enediyne antitumor antibiotic neocarzinostatin.
Cooke
Heather A
HA
Department of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, Massachusetts 02467, USA.
Zhang
Jian
J
Griffin
Meghan A
MA
Nonaka
Koichi
K
Van Lanen
Steven G
SG
Shen
Ben
B
Bruner
Steven D
SD
D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis*; D001426:Bacterial Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D002264:Carboxylic Acids / Q000737:chemistry / Q000378:metabolism*; D003065:Coenzyme A / Q000378:metabolism*; D015964:Gene Expression Regulation, Bacterial; D015394:Molecular Structure; D005810:Multigene Family; D009281:Naphthalenes / Q000737:chemistry / Q000378:metabolism*; D013302:Streptomyces / Q000201:enzymology; D009353:Zinostatin / Q000096:biosynthesis*
D000903:Antibiotics, Antineoplastic; D001426:Bacterial Proteins; D002264:Carboxylic Acids; D009281:Naphthalenes; C085312:1-naphthoic acid; D009353:Zinostatin; D003065:Coenzyme A