Synthesis and antifungal activity of some new 3-hydroxy-2-(1-phenyl-3-aryl-4-pyrazolyl) chromones.
Seven new 3-hydroxy-2-(1-phenyl-3-aryl-4-pyrazolyl) chromones 4a-g have been synthesized by the oxidation of 2-hydroxychalcone analogues of pyrazole 3a-g with hydrogen peroxide (H(2)O(2)) in KOH-MeOH by Algar Flynn Oymanda (AFO) reaction. The structures of the compounds 4 were established by the combined use of (1)H NMR, IR and mass spectra. All the seven compounds were tested in vitro for their antifungal activity against three phytopathogenic fungi, namely Helminthosporium species, Fusarium oxysporum and Alternaria alternata. Five compounds 4a, 4b, 4c, 4e and 4f were associated with substantially higher antifungal activity than commercial antifungal compound Actidione (cycloheximide) against all three phytopathogenic fungi.
Prakash
Om
O
Department of Chemistry, Kurukshetra University, Kurukshetra 136119 Haryana, India. dromprakash50@rediffmail.com
Kumar
Rajesh
R
Parkash
Vipin
V
D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002867:Chromones / Q000138:chemical synthesis* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D013055:Spectrophotometry, Infrared
D000935:Antifungal Agents; D002867:Chromones