[Effect of tacrolimus on the growth cycle of murine hair follicles].
OBJECTIVE
To explore the effect of tacrolimus on murine hair follicle cycle.


METHODS
Hematoxylin-eosin dyeing and reverse transcription-polymerase chain raction techniques were used.


RESULTS
Five days after depilation, the hair follicles in both the tacrolimus group and the minoxidil group was in anagen V, while that in the vaseline group was in anagen III. vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF) were detected in back skin in both the tacrolimus group and the minoxidil group, but not in the vaseline group.


CONCLUSIONS
Tacrolimus can promote the growth of hair by stimulating the hair follicle to enter anagen V in mice, which may be explained by the effects of VEGF and HGF.
Tian
Ting
T
Department of Dermatology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Fan
Wei-Xin
WX
Dai
Ye-Qin
YQ
Liu
Li-Ping
LP
D000818:Animals; D018859:Hair Follicle / Q000187:drug effects* / Q000502:physiology; D017228:Hepatocyte Growth Factor / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D008914:Minoxidil / Q000494:pharmacology; D012867:Skin / Q000187:drug effects / Q000378:metabolism; D016559:Tacrolimus / Q000494:pharmacology*; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
D042461:Vascular Endothelial Growth Factor A; C467480:vascular endothelial growth factor A, mouse; D008914:Minoxidil; D017228:Hepatocyte Growth Factor; D016559:Tacrolimus