Anti-inflammatory and analgesic alkaloid from Sida cordifolia linn.
The analgesic and anti-inflammatory activities of a new alkaloid, 1,2,3,9-tetrahydro-pyrrolo [2,1-b] quinazolin-3-ylamine (compound 1) isolated from Sida cordifolia Linn. were investigated in animal models. In the acetic acid induced writhing model, the compound 1 showed 25.4 (P<0.05) and 52.43% (P<0.01) inhibition of writhing response at doses of 25 and 50 mg/kg body weight respectively. The alkaloid also produced significant increase in the tail flick latency in radiant heat tail-flick method. In Carrageenan induced rat paw edema the compound 1 produced 16.93 and 24.43 % inhibition of paw edema at the doses of 25 and 50 mg/kg body weight respectively at the third hour of study.
Sutradhar
Ranajit Kumar
RK
Department of Chemistry, Chittagong University of Engineering and Technology (CUET), Chittagong-4349, Bangladesh. rksutradhar2002@yahoo.com
Rahman
Akm Matior
AM
Ahmad
Mesbahuddin
M
Bachar
Sitesh Chandra
SC
Saha
Achinto
A
Roy
Tapashi Ghosh
TG
D019342:Acetic Acid; D018712:Analgesics, Non-Narcotic / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000302:isolation & purification / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects; D002351:Carrageenan; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D005260:Female; D008297:Male; D019660:Malvaceae / Q000737:chemistry*; D051379:Mice; D010147:Pain Measurement; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D011799:Quinazolines / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats; D020318:Rats, Long-Evans; D011930:Reaction Time / Q000187:drug effects
C522874:1,2,3,9-tetrahydro-pyrrolo(2,1-b)quinazolin-3-ylamine; D018712:Analgesics, Non-Narcotic; D000894:Anti-Inflammatory Agents, Non-Steroidal; D010936:Plant Extracts; D011799:Quinazolines; D002351:Carrageenan; D019342:Acetic Acid