title: Augmentation index and central aortic stiffness in middle-aged to elderly individuals.
abstract: BACKGROUND
  Increased aortic stiffness contributes to systolic hypertension and increased cardiovascular risk. The augmentation index (AI), ie, the percentage of central pulse pressure attributed to reflected wave overlap in systole, was proposed as a noninvasive indicator of increased arterial stiffness. We evaluated this hypothesis by investigating relations between AI and other direct measures of aortic stiffness.
  
  
  METHODS
  Tonometric carotid- and femoral-pressure waveforms, Doppler aortic flow, and aortic-root diameter were assessed in 123 individuals with uncomplicated systolic hypertension and 29 controls of comparable age and sex. Carotid-femoral pulse-wave velocity (PWV) was assessed from the carotid-femoral time delay and body-surface measurements. Aortic PWV was assessed from the ratio of the upstroke of carotid pressure and aortic flow velocity and was used to calculate proximal aortic compliance as [aortic area]/[1.06 x (aortic PWV)(2)].
  
  
  RESULTS
  Partial correlations (adjusted for age, sex, presence of hypertension, height, weight, and systolic ejection period) showed no association between AI and carotid-femoral PWV (R = -0.05, P = .54). The AI was significantly though weakly related directly with aortic compliance (R = 0.21, P = .012) and inversely with aortic PWV (R = -0.198, P = .017). However, higher stiffness (lower compliance and higher PWV) was associated with lower AI.
  
  
  CONCLUSIONS
  Increased AI is not a reliable surrogate for increased aortic stiffness. Decreasing AI with decreasing compliance (increasing aortic stiffness) may be attributable to impedance matching and reduced wave reflection at the interface between the aorta and the muscular arteries.
authors.affiliation: Cardiovascular Engineering, Inc., Waltham, Massachusetts 02453, USA.
authors.forename: Mitul
authors.initials: M
authors.lastname: Vyas
authors.forename: Joseph L
authors.initials: JL
authors.lastname: Izzo
authors.forename: Yves
authors.initials: Y
authors.lastname: Lacourcière
authors.forename: J Malcolm O
authors.initials: JM
authors.lastname: Arnold
authors.forename: Mark E
authors.initials: ME
authors.lastname: Dunlap
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Amato
authors.forename: Marc A
authors.initials: MA
authors.lastname: Pfeffer
authors.forename: Gary F
authors.initials: GF
authors.lastname: Mitchell
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology*; D001011:Aorta / Q000503:physiopathology*; D015415:Biomarkers; D001794:Blood Pressure / Q000502:physiology*; D001827:Body Height / Q000502:physiology; D003430:Cross-Sectional Studies; D004548:Elasticity; D004562:Electrocardiography; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D008962:Models, Theoretical; D011237:Predictive Value of Tests; D012039:Regional Blood Flow / Q000502:physiology; D015203:Reproducibility of Results; D012720:Severity of Illness Index; D012737:Sex Factors
chemical_list: D015415:Biomarkers