Further delineation of interstitial chromosome 6 deletion syndrome and review of the literature.
Interstitial deletions of chromosome 6q are a relatively rare finding. Deletions have ranged from the loss of a single band to larger deletions spanning multiple bands. The clinical phenotype varies, but some features commonly seen include cardiac anomalies, hypotonia, facial dysmorphism and mental retardation. To further delineate the syndrome, we report an infant with facial dysmorphism, ectrodactyly and tetralogy of Fallot owing to interstitial deletion 6q16.1-6q22.32. On array comparative genomic hybridization analysis, the deletion spanned from the 93 377 323rd base to the 127 650 582nd base on chromosome 6 [coordinates are based on Human Mar. 2006 (hg18) assembly of International Human Genome Sequencing Consortium]. A literature review identified 16 additional cases with overlapping interstitial deletions of chromosome 6q between q13 and q23.1. Genotype-phenotype correlations are considered.
Zherebtsov
Monica M
MM
Departments of Pediatrics Pathology Divisions of Pediatric Genetics Neonatology, Bristol-Myers Squibb Children's Hospital at Robert Wood Johnson University Hospital, UMDNJ-Robert Wood Johnson Medical School Department of Pediatrics, Center for Human and Molecular Genetics, UMDNJ-NJ Medical School, Newark, New Jersey, USA.
Klein
Rachel T
RT
Aviv
Hana
H
Toruner
Gokce A
GA
Hanna
Nazeeh N
NN
Brooks
Susan Sklower
SS
D000015:Abnormalities, Multiple / Q000235:genetics*; D002872:Chromosome Deletion; D002896:Chromosomes, Human, Pair 6 / Q000235:genetics*; D005260:Female; D018628:Gene Dosage; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009693:Nucleic Acid Hybridization; D013577:Syndrome