Heat shock protein 60 antibody. A new marker for subsequent atrial fibrillation development.
OBJECTIVE
To examined the pre- and post- operative anti-HSP60 antibodies of serum from patients in preoperative sinus rhythm.


METHODS
We prospectively studied 45 consecutive patients admitted for elective CABG from 2004 to 2005. We randomly selected 10 patients developing AF (study sample [Group A]) and 10 postoperative patients without AF (control [Group B]. The study took place at the Department of Cardiovascular Surgery, Hacettepe University, Ankara, Turkey.


RESULTS
Anti-HSP60 IgG value was 27.76 +/- 12.69 absorbance units (AU) in Group A preoperatively and decreased to 13.73 +/- 5.51 AU postoperatively. Controversially, preoperative value of anti-HSP60 IgG was 9.94 +/- 2.92 AU and decreased to 6.72 +/- 1.89 AU, postoperatively in Group B. Statistical analysis showed significant difference regarding preoperative anti-HSP60 IgG levels in Group A compared to Group B, which might be interpreted as an association between postoperative AF and preoperative levels of anti-HSP60 IgG.


CONCLUSIONS
We provide the first evidence demonstrating the association of pre- and post- operative circulating anti-HSP60 antibodies with postoperative AF. These results suggest that serum HSP60 antibody levels may be a marker for subsequent development of AF.
Oc
Mehmet
M
Department of Cardiovascular Surgery, Hacettepe University Faculty of Medicine, Sihhiye, Ankara, Turkey.
Ucar
Halil Ibrahim
HI
Pinar
Asli
A
Akbulut
Birkan
B
Oc
Bahar
B
Akinci
Seda Banu
SB
Akyon
Yakut
Y
Kanbak
Meral
M
Boke
Erkmen
E
Dogan
Riza
R
D001281:Atrial Fibrillation / Q000175:diagnosis*; D001323:Autoantibodies / Q000097:blood*; D015415:Biomarkers / Q000097:blood*; D018834:Chaperonin 60 / Q000276:immunology*; D001026:Coronary Artery Bypass; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D011446:Prospective Studies
D001323:Autoantibodies; D015415:Biomarkers; D018834:Chaperonin 60