title: Stimulation of mucosal and systemic antibody responses against recombinant transferrin-binding protein B of Actinobacillus pleuropneumoniae with chitosan after tracheal administration in piglets.
abstract: This study evaluated the suitability of using a chitosan formulation as an adjuvant to enhance both the mucosal and systemic immune responses against recombinant transferrin-binding protein B (rTbp B) of Actinobacillus pleuropneumoniae via direct tracheal administration. The chitosan formulation was found to enhance mucosal immune response, as measured by the secretory IgA level in lung lavage fluid and lung homogenate extracts, and systemic immune response, as measured by the serum IgG level.
authors.affiliation: Biotherapy Human Resources Center, College of Veterinary Medicine, Chonnam National University, Gwangju, Korea.
authors.forename: Tae Jung
authors.initials: TJ
authors.lastname: Kim
authors.forename: Kwang Hyun
authors.initials: KH
authors.lastname: Kim
authors.forename: Jae Il
authors.initials: JI
authors.lastname: Lee
mesh_terms: D016977:Actinobacillus pleuropneumoniae / Q000276:immunology*; D000276:Adjuvants, Immunologic / Q000008:administration & dosage; D000818:Animals; D000917:Antibody Formation / Q000276:immunology*; D015153:Blotting, Western; D001992:Bronchoalveolar Lavage Fluid / Q000276:immunology; D048271:Chitosan / Q000008:administration & dosage / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D018928:Immunity, Mucosal / Q000276:immunology*; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000097:blood; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000276:immunology*; D034421:Sus scrofa; D014132:Trachea / Q000276:immunology; D033882:Transferrin-Binding Protein B / Q000008:administration & dosage / Q000276:immunology*
chemical_list: D000276:Adjuvants, Immunologic; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D011994:Recombinant Proteins; D033882:Transferrin-Binding Protein B; D048271:Chitosan