title: Indole alkaloids produced by a marine fungus isolate of Penicillium janthinellum Biourge.
abstract: Three new indole alkaloids, shearinines D, E, and F (1-3), together with the known shearinine A (4) were isolated from the marine-derived strain of the fungus Penicillium janthinellum Biourge. The chemical structures of 1-4 were established by 2D NMR and HREIMS data. Shearinines A, D, and E induce apoptosis in human leukemia HL-60 cells, and shearinine E also inhibits EGF-induced malignant transformation of JB6 P+ Cl 41 cells in a soft agar.
authors.affiliation: Pacific Institute of Bioorganic Chemistry, Far East Branch of the Russian Academy of Sciences, Vladivostok 22, Russian Federation.
authors.forename: Olga F
authors.initials: OF
authors.lastname: Smetanina
authors.forename: Anatoly I
authors.initials: AI
authors.lastname: Kalinovsky
authors.forename: Yuliya V
authors.initials: YV
authors.lastname: Khudyakova
authors.forename: Mikhail V
authors.initials: MV
authors.lastname: Pivkin
authors.forename: Pavel S
authors.initials: PS
authors.lastname: Dmitrenok
authors.forename: Sergey N
authors.initials: SN
authors.lastname: Fedorov
authors.forename: Hong
authors.initials: H
authors.lastname: Ji
authors.forename: Jong-Young
authors.initials: JY
authors.lastname: Kwak
authors.forename: Tatyana A
authors.initials: TA
authors.lastname: Kuznetsova
mesh_terms: D016588:Anticarcinogenic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008386:Marine Biology; D015394:Molecular Structure; D010407:Penicillium / Q000737:chemistry*
chemical_list: D016588:Anticarcinogenic Agents; D000970:Antineoplastic Agents; D026121:Indole Alkaloids; C521532:shearinine D; C521534:shearinine E; C521533:shearinine F