Endothelial lipase gene polymorphism is associated with acute myocardial infarction, independently of high-density lipoprotein-cholesterol levels.
BACKGROUND
Endothelial lipase (EL) is a major determinant of high-density lipoprotein-cholesterol (HDL-C) metabolism and promotes monocytes recruitment. The local expression of EL could influence atherogenesis directly, in addition to its systemic role in HDL metabolism. The EL gene has a common 584C/T polymorphism, but it is unclear whether this polymorphism is associated with HDL-C levels or acute myocardial infarction (AMI).


RESULTS
A case-control study of 107 AMI patients and 107 control subjects was conducted. T allele frequency was lower in the AMI group than in controls (0.18 vs 0.26, p<0.05). No significant association was found between the 584C/T polymorphism and HDL-C levels. Multivariate regression analyses showed that the association of the T allele with AMI was statistically significant and independent of other risk factors when age, sex, hypertension, hypercholesterolemia, and diabetes mellitus were included in the analyses (odds ratio (OR), 0.52; 95% confidence interval (95% CI) 0.28-0.98; p=0.04). However, when smoking status was included, the association of the T allele with AMI did not remain statistically significant (OR, 0.61; 95% CI 0.32-1.18; p=0.14).


CONCLUSIONS
The 584C/T polymorphism of the EL gene was associated with AMI independently of HDL-C levels and thus may be involved in the pathogenesis of AMI.
Shimizu
Masakatsu
M
Division of General Medical Science, Department of General Therapeutics, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan.
Kanazawa
Kenji
K
Hirata
Ken-ichi
K
Ishida
Tatsuro
T
Hiraoka
Eiji
E
Matsuda
Yasuaki
Y
Iwai
Chikao
C
Miyamoto
Yoshitomo
Y
Hashimoto
Masayoshi
M
Kajiya
Teishi
T
Akita
Hozuka
H
Yokoyama
Mitsuhiro
M
D000208:Acute Disease; D000367:Age Factors; D016022:Case-Control Studies; D008076:Cholesterol, HDL / Q000097:blood*; D003920:Diabetes Mellitus / Q000201:enzymology / Q000235:genetics; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000201:enzymology / Q000235:genetics; D006973:Hypertension / Q000201:enzymology / Q000235:genetics; D008049:Lipase / Q000235:genetics* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009203:Myocardial Infarction / Q000201:enzymology* / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D012737:Sex Factors
D008076:Cholesterol, HDL; C410382:LIPG protein, human; D008049:Lipase