title: [CT perfusion study of acute local cerebral infarction in rhesus monkeys].
abstract: OBJECTIVE
  To explore the value of CT perfusion in early diagnosis and management of superacute local cerebral infarction in rhesus monkeys.
  
  
  METHODS
  Acute local cerebral infarction was induced in the rhesus monkeys during digital subtraction angiography (DSA) by introduction of pale thrombus prepared from autologous blood into the M1 branch of the middle cerebral artery (MCA). Plain CT scan and CT perfusion scanning were performed at different time points before and after DSA operation, and the results were analyzed in conjunction with the pathologic changes.
  
  
  RESULTS
  Ischemic lesions were displayed on CT perfusion images, which showed local hypoperfusion, reduced cerebral blood flow and volume, and mean transit time delay in the compromised area. Local hypointense infarct area was identified in plain CT scan 24 h after the DSA operation, and the results were in good agreement with pathological examination during autopsy.
  
  
  CONCLUSIONS
  CT perfusion imaging of the brain can accurately capture the cerebral perfusion deficits in acute ischemic stroke before morphologic changes take place, and therefore provides good means for thrombolytic treatment evaluation of stroke.
authors.affiliation: Imaging Center of Radiology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. jocky0606@163.com
authors.forename: Zhuo-kai
authors.initials: ZK
authors.lastname: He
authors.forename: Yi-kai
authors.initials: YK
authors.lastname: Xu
authors.forename: Wei-jia
authors.initials: WJ
authors.lastname: Qiu
authors.forename: Yan-xian
authors.initials: YX
authors.lastname: Deng
authors.forename: Zhi-peng
authors.initials: ZP
authors.lastname: Zhou
authors.forename: Zhi-hong
authors.initials: ZH
authors.lastname: Huang
authors.forename: Fei-ling
authors.initials: FL
authors.lastname: Feng
authors.forename: Ying
authors.initials: Y
authors.lastname: Wei
authors.forename: Rui-jing
authors.initials: RJ
authors.lastname: Gan
authors.forename: Jun-xiong
authors.initials: JX
authors.lastname: Yu
mesh_terms: D000208:Acute Disease; D000818:Animals; D001921:Brain / Q000000981:diagnostic imaging*; D002545:Brain Ischemia / Q000175:diagnosis; D002544:Cerebral Infarction / Q000175:diagnosis*; D003287:Contrast Media / Q000008:administration & dosage; D042241:Early Diagnosis; D008253:Macaca mulatta; D010477:Perfusion; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D003287:Contrast Media