Hydrolytic cleavage of DNA by a ruthenium(II) polypyridyl complex.
The complex [Ru(bpy)2(BPG)]Cl2 (1) containing hydrogen-bond donor (N-H atoms) and acceptor (O atoms) groups mediates hydrolytic cleavage of plasmid pBR322 DNA in an enzyme-like manner. The kinetic aspects of DNA cleavage under pseudo- and true-Michaelis-Menten conditions are detailed.
Deshpande
Megha S
MS
Department of Chemistry, University of Pune, Pune- 411 007, India.
Kumbhar
Anupa A
AA
Kumbhar
Avinash S
AS
D004247:DNA / Q000737:chemistry*; D006868:Hydrolysis; D007700:Kinetics; D015394:Molecular Structure; D011725:Pyridines / Q000737:chemistry*; D012428:Ruthenium / Q000737:chemistry*
D011725:Pyridines; D012428:Ruthenium; D004247:DNA; C023666:pyridine