title: [The treatment of hyperemesis gravidarum with chlorobutanol-caffeine rectal suppositories in Denmark: practice and evidence].
abstract: BACKGROUND
  In Denmark chlorobutanol-caffeine rectal suppositories are prescribed by some obstetric departments for the treatment of hyperemesis gravidarum.
  
  
  METHODS
  We have investigated the extent of this use by questionnaire, and we have performed a literature review on the evidence of efficacy and safety.
  
  
  RESULTS
  The use of chlorobutanol-caffeine rectal suppositories was reported by 5 out of 28 obstetric departments in Denmark. The literature search revealed that there is very sparse information on chlorobutanol. No evidence was found of safety during pregnancy in humans or efficiency as antiemetic treatment in hyperemesis gravidarum.
  
  
  CONCLUSIONS
  There is no evidence of the efficacy or safety of chlorobutanol-caffeine suppositories for the treatment of hyperemesis gravidarum.
authors.affiliation: Universitetshospital, Afdeling for Biokemi, Farmakologi og Genetik. bohn@dadlnet.dk
authors.forename: Herdis Bohn Olesen
authors.initials: HB
authors.lastname: Brødbaek
authors.forename: Per
authors.initials: P
authors.lastname: Damkier
mesh_terms: D000932:Antiemetics / Q000008:administration & dosage* / Q000009:adverse effects; D002110:Caffeine / Q000008:administration & dosage* / Q000009:adverse effects; D002724:Chlorobutanol / Q000008:administration & dosage* / Q000009:adverse effects; D004338:Drug Combinations; D004363:Drug Utilization; D019317:Evidence-Based Medicine; D005260:Female; D006801:Humans; D006939:Hyperemesis Gravidarum / Q000188:drug therapy*; D011247:Pregnancy; D012449:Safety; D013488:Suppositories; D011795:Surveys and Questionnaires
chemical_list: D000932:Antiemetics; D004338:Drug Combinations; D013488:Suppositories; D002110:Caffeine; D002724:Chlorobutanol