title: Synthesis of some novel 2,4-disubstituted thiazoles as possible antimicrobial agents.
abstract: A series of novel 4-aryl/chloroalkyl-2-(2,3,5-trichlorophenyl)-1,3-thiazoles (5a-g and 7a-e) were synthesized by condensing 2,3,5-trichlorobenzenecarbothioamide with phenacyl bromide/dichloroacetone. 2,3,5-Trichlorobenzaldehyde thiosemicarbazone on treatment with phenacyl bromide afforded 4-aryl-2-(2,3,5-trichlorophenylidenehydrazino)-1,3-thiazoles (10a-g) in good yield. The newly synthesized compounds are characterized by IR, (1)H NMR and mass spectral studies. These compounds were also screened for their antibacterial and antifungal activities. Preliminary results reveal that some of the synthesized compounds are showing promising antimicrobial activity.
authors.affiliation: Department of Chemistry, Mangalore University, Mangalagangothri, Konaje, Mangalore, Karnataka 574199, India.
authors.forename: Prakash
authors.initials: P
authors.lastname: Karegoudar
authors.forename: Mari Sithambaram
authors.initials: MS
authors.lastname: Karthikeyan
authors.forename: Dasappa Jagadeesh
authors.initials: DJ
authors.lastname: Prasad
authors.forename: Manjathuru
authors.initials: M
authors.lastname: Mahalinga
authors.forename: Bantwal Shivarama
authors.initials: BS
authors.lastname: Holla
authors.forename: Nalilu Sucheta
authors.initials: NS
authors.lastname: Kumari
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013055:Spectrophotometry, Infrared; D013844:Thiazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D013844:Thiazoles