[Advancements in expression of vascular endothelial growth factor receptors in skin diseases].
Vascular endothelial growth factor (VEGF) exerts its biological functions by its specific VEGF receptors (VEGFR), which includes VEGFR-1, VEGFR-2, VEGFR-3, neuropilin-1, and neuropilin-2. These VEGFR distributes in endothelial cells, and are also expressed in normal skin, inflammatory skin diseases, and skin cancers. The VEGF-VEGFR signaling pathway may be a new key target in the management of the skin diseases.
Yang
Xiao-Hong
XH
Department of Dermatology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China.
Man
Xiao-Yong
XY
Zheng
Min
M
D000818:Animals; D006801:Humans; D040262:Receptors, Vascular Endothelial Growth Factor / Q000096:biosynthesis*; D015398:Signal Transduction; D012871:Skin Diseases / Q000378:metabolism*; D042461:Vascular Endothelial Growth Factor A / Q000502:physiology*
D042461:Vascular Endothelial Growth Factor A; D040262:Receptors, Vascular Endothelial Growth Factor