Lipid nanoparticles for improved topical application of drugs for skin diseases.
Due to the lower risk of systemic side effects topical treatment of skin disease appears favourable, yet the stratum corneum counteracts the penetration of xenobiotics into viable skin. Particulate carrier systems may mean an option to improve dermal penetration. Since epidermal lipids are found in high amounts within the penetration barrier, lipid carriers attaching themselves to the skin surface and allowing lipid exchange between the outermost layers of the stratum corneum and the carrier appear promising. Besides liposomes, solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) have been studied intensively. Here we describe the potential of these carrier systems and compare the dermal uptake from SLN and NLC to the one of alternative vehicle systems. A special focus is upon the interactions of active ingredients and the lipid matrix as well as the quantification of dermal penetration.
Schäfer-Korting
Monika
M
Institut für Pharmazie, Pharmakologie und Toxikologie, der Freien Universität Berlin, D-14195 Berlin, Germany. msk@zedat.fu-berlin.de
Mehnert
Wolfgang
W
Korting
Hans-Christian
HC
D000287:Administration, Topical; D000818:Animals; D004337:Drug Carriers / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans; D008055:Lipids / Q000008:administration & dosage / Q000627:therapeutic use; D053758:Nanoparticles / Q000008:administration & dosage* / Q000627:therapeutic use; D004364:Pharmaceutical Preparations / Q000008:administration & dosage / Q000378:metabolism; D012869:Skin Absorption; D012871:Skin Diseases / Q000188:drug therapy* / Q000378:metabolism
D004337:Drug Carriers; D008055:Lipids; D004364:Pharmaceutical Preparations