[Recurrence of differentiated thyroid carcinoma without concomitant elevation of serum thyroglobulin: report of two cases].
Thyroid carcinoma is the most prevalent endocrine tumor, and the papillary carcinoma (PC) is the most common histological type. In the follow-up, after thyroidectomy serum thyroglobulin (s-Tg) is used as a marker to evaluate recurrence of thyroid carcinoma. In most cases, this parameter allows an adequate diagnosis, but occasionally s-Tg may miss the detection of a recurrence. We report a 57 year-old female and a 36 year-old male subjected to a total thyroidectomy for a papillary thyroid carcinoma with intermediate and high-risk of recurrence. Both had a cervical recurrence without a concomitant increase in s-Tg levels. In both, Tg staining was positive in the tumor cells. These cases confirm that in these patients, the follow-up must be done with measurement of s-Tg and complementary diagnostic tests.
Velasco
Soledad
S
Departamento de Endocrinología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
Solar
Antonieta
A
Cruz
Francisco
F
Quintana
Juan Carlos
JC
León
Augusto
A
Mosso
Lorena
L
Fardella
Carlos
C
D000328:Adult; D014408:Biomarkers, Tumor / Q000097:blood*; D001706:Biopsy; D002291:Carcinoma, Papillary / Q000097:blood* / Q000556:secondary / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000097:blood* / Q000175:diagnosis / Q000601:surgery; D013954:Thyroglobulin / Q000097:blood*; D013964:Thyroid Neoplasms / Q000097:blood* / Q000473:pathology / Q000601:surgery
D014408:Biomarkers, Tumor; D013954:Thyroglobulin