title: Prediction of monitoring data for 239Pu accidentally injected via wound site based on the proposed NCRP wound model.
abstract: In response to the consultation from the National Council on Radiation Protection and Measurements (NCRP) to the International Commission on Radiological Protection (ICRP) committee 2, retention and excretion of 239Pu deposited at wound site were calculated by coupling together the proposed NCRP wound model and the current ICRP systemic model of Pu. The physicochemical forms considered were the soluble form categorized into 'Strong Retention', and the colloidal, particulate and fragmentary forms. The results are summarized as follows. If in soluble form, immediate medical intervention is needed to prevent uptake of radionuclides to body tissues, and prompt wound monitoring is essential for an accurate estimation of the initially deposited radioactivity. If in particulate form, a multi-component exponential equation leads to an overestimation of the absorption rate to blood because of significant lymph node drainage. The committed doses in the organs for direct transfer of 239Pu to the blood may be applied to every cases of accidental injection except for fragments.
authors.affiliation: School of Health Sciences, Nagoya University, 1-1-20, Daiko-minami, Higashi-ku, Nagoya, Japan. ishigure@met.nagoya-u.ac.jp
authors.forename: N
authors.initials: N
authors.lastname: Ishigure
mesh_terms: D001822:Body Burden; D003198:Computer Simulation; D005547:Foreign Bodies / Q000150:complications / Q000503:physiopathology*; D006801:Humans; D007267:Injections / Q000009:adverse effects; D007700:Kinetics; D008657:Metabolic Clearance Rate; D008954:Models, Biological; D011005:Plutonium / Q000493:pharmacokinetics* / Q000633:toxicity*; D011832:Radiation Injuries / Q000209:etiology / Q000503:physiopathology*; D011834:Radiation Monitoring / Q000379:methods*; D012062:Relative Biological Effectiveness; D014950:Wounds, Penetrating / Q000209:etiology / Q000503:physiopathology*
chemical_list: D011005:Plutonium