title: Structure-activity relationships of novel N-acyloxy-1,4-dihydropyridines as P-glycoprotein inhibitors.
abstract: Series of novel N-acyloxy-1,4-dihydropyridines have been synthesized and evaluated as P-glycoprotein inhibitors in an in vitro assay to estimate their potential to act as multidrug resistance modulators in cancer cells. Structure-activity relationships are discussed and prove a significant and regiospecific influence of certain functional groups.
authors.affiliation: Institute of Pharmacy, Martin Luther University, Halle, Germany.
authors.forename: Burkhardt
authors.initials: B
authors.lastname: Voigt
authors.forename: Claudius
authors.initials: C
authors.lastname: Coburger
authors.forename: Joséf
authors.initials: J
authors.lastname: Monár
authors.forename: Andreas
authors.initials: A
authors.lastname: Hilgeroth
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000037:antagonists & inhibitors*; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D045744:Cell Line, Tumor; D004095:Dihydropyridines / Q000737:chemistry* / Q000494:pharmacology*; D019008:Drug Resistance, Neoplasm / Q000187:drug effects; D008223:Lymphoma / Q000188:drug therapy; D051379:Mice; D013329:Structure-Activity Relationship
chemical_list: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000970:Antineoplastic Agents; D004095:Dihydropyridines