Benzothiazines in organic synthesis. The preparation of enantiomerically pure 4-substituted quinolones.
3,4-Dihydroquinolin-2(1H)-ones have potential biological and pharmacological significance. Enantiomerically pure benzothiazines, readily available via an intramolecular addition of a sulfoximine-stabilized carbanion to an alpha,beta-unsaturated ester, could be used as templates for making a series of enantiomerically pure 3,4-dihydroquinolin-2(1H)-ones under mild conditions.
Harmata
Michael
M
Department of Chemistry, University of Missouri-Columbia, Columbia, MO 65203, USA. harmatam@missouri.edu
Hong
Xuechuan
X
D004952:Esters / Q000138:chemical synthesis / Q000737:chemistry; D015363:Quinolones / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D013843:Thiazines / Q000138:chemical synthesis / Q000737:chemistry
D004952:Esters; D015363:Quinolones; D013843:Thiazines