title: The development of magnetic degradable DP-Bioglass for hyperthermia cancer therapy.
abstract: In this study, a novel magnetic degradable material was developed by adding Fe ions into DP-Bioglass (Na(2)O-CaO-P(2)O(5)-SiO(2)) as thermoseed for hyperthermia cancer therapy under an alternating magnetic field. We have investigated the properties of developed magnetic DP-Bioglass including morphology, chemical composition, and magnetism. The degradability was conducted by measuring the released concentrations of Na, Ca, Si, P, and Fe ions. The biocompatibility was analyzed by biological assays, and the functional hyperthermia effect to cancer cells was evaluated by in vitro cell culture test. In the results, the morphology of synthesized magnetic DP-Bioglass was revealed in sphere and rod shape with particle size around 50-100 nm. From the hysteresis loop analysis, it showed that the group of Fe/Bioglass = 0.2 possessed the maximum magnetization property. When cultured with fibroblasts, the magnetic DP-Bioglass had no significant influence on cell viability and mediated low cytotoxicity. The thermal-induced property demonstrated that after exposure to an alternating magnetic field, the cell number of human Caucasian lung carcinoma cells (A549) was significantly decreased when temperature was increasing to 45 degrees C. In brief, successfully incorporated with Fe ions by sol-gel method, this magnetic degradable DP-Bioglass possessed the potential and properties of hyperthermia effect to lung carcinoma cells.
authors.affiliation: Institute of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei, Taiwan.
authors.forename: Tzu-Wei
authors.initials: TW
authors.lastname: Wang
authors.forename: Hsi-Chin
authors.initials: HC
authors.lastname: Wu
authors.forename: Wei-Ren
authors.initials: WR
authors.lastname: Wang
authors.forename: Feng-Huei
authors.initials: FH
authors.lastname: Lin
authors.forename: Pei-Jen
authors.initials: PJ
authors.lastname: Lou
authors.forename: Ming-Jium
authors.initials: MJ
authors.lastname: Shieh
authors.forename: Tai-Horng
authors.initials: TH
authors.lastname: Young
mesh_terms: D045744:Cell Line, Tumor; D002516:Ceramics / Q000737:chemistry* / Q000627:therapeutic use; D005347:Fibroblasts / Q000378:metabolism / Q000648:ultrastructure*; D006801:Humans; D006979:Hyperthermia, Induced; D007477:Ions / Q000737:chemistry; D007501:Iron / Q000378:metabolism / Q000627:therapeutic use; D008175:Lung Neoplasms / Q000628:therapy* / Q000648:ultrastructure*; D008280:Magnetics; D008855:Microscopy, Electron, Scanning; D010316:Particle Size
chemical_list: C022107:Bioglass; D007477:Ions; D007501:Iron