Effect of oral D-penicillamine vs. colchicine on experimentally induced peritoneal adhesions in rats.
OBJECTIVE
To evaluate the effects of d-penicillamine on prevention or reduction of adhesion band formation and to compare its effects with those of colchicine in an animal model.


METHODS
A prospective experimental study.


METHODS
Rats in an academic research environment.


METHODS
Eighty female rats were randomly divided into four equal groups. In the end, group 4 was excluded because of high mortality rates.


METHODS
Adhesion bands were induced by intraperitoneal injection of 2.5 mL of a 10% sterile talc solution. The first group served as control, group 2 received oral D-penicillamine (35 mg/kg per day), group 3 received oral colchicines (0.02 mg/kg per day), and group 4 received both drugs for 3 consecutive weeks.


METHODS
Formation of adhesion bands was quantitatively graded according to the Nair classification.


RESULTS
The proportion of control rats with substantial adhesion bands was significantly higher than that of rats in groups 2 or 3 (84.2%, 20%, and 33.3%). No difference regarding the grades of adhesion bands was found between the D-penicillamine and colchicine groups.


CONCLUSIONS
Oral D-penicillamine is as effective as oral colchicine in prevention of peritoneal adhesion band formation in rats. Use of D-penicillamine for this purpose should be weighed against its possible side effects.
Nikeghbalian
Saman
S
Shiraz Organ Transplantation Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran. transpln@sums.ac.ir
Atefi
Sohrab
S
Kazemi
Kourosh
K
Roshan
Naghmeh
N
Tanideh
Nader
N
Jalaeian
Hamed
H
D000284:Administration, Oral; D000818:Animals; D003078:Colchicine / Q000008:administration & dosage*; D005260:Female; D010396:Penicillamine / Q000008:administration & dosage*; D010537:Peritoneum / Q000187:drug effects* / Q000473:pathology; D011446:Prospective Studies; D051381:Rats; D000267:Tissue Adhesions / Q000473:pathology / Q000517:prevention & control*
D010396:Penicillamine; D003078:Colchicine