title: Tympanic membrane breakdown after intratympanic injection of steroids in irradiated ears.
abstract: OBJECTIVE
  To describe a rare complication of intratympanic injection of steroids in susceptible ears.
  
  
  METHODS
  We present two patients with a history of irradiation involving the injected ear.
  
  
  METHODS
  Therapeutic.
  
  
  METHODS
  Tympanic membrane condition after intratympanic injection of steroids.
  
  
  RESULTS
  Total or near-total breakdown of the irradiated tympanic membrane.
  
  
  CONCLUSIONS
  Tympanic membranes with an impaired wound-healing ability, together with exposure to intratympanic steroids, may be at risk for total or near-total breakdown.
authors.affiliation: University of Miami School of Medicine, Department of Otolaryngology, University of Miami Ear Institute, Miami, Florida 33101, USA.
authors.forename: Yisgav
authors.initials: Y
authors.lastname: Shapira
authors.forename: Fred F
authors.initials: FF
authors.lastname: Telischi
mesh_terms: D000236:Adenoma / Q000150:complications / Q000532:radiotherapy; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage* / Q000009:adverse effects*; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage* / Q000009:adverse effects*; D003907:Dexamethasone / Q000008:administration & dosage / Q000009:adverse effects; D004806:Ependymoma / Q000150:complications / Q000532:radiotherapy; D006319:Hearing Loss, Sensorineural / Q000150:complications / Q000188:drug therapy; D006801:Humans; D015192:Infratentorial Neoplasms / Q000150:complications / Q000532:radiotherapy; D007267:Injections; D008297:Male; D008575:Meniere Disease / Q000150:complications / Q000188:drug therapy; D008775:Methylprednisolone / Q000008:administration & dosage / Q000009:adverse effects; D008875:Middle Aged; D010307:Parotid Neoplasms / Q000150:complications / Q000532:radiotherapy; D011878:Radiotherapy / Q000009:adverse effects*; D014432:Tympanic Membrane / Q000187:drug effects* / Q000528:radiation effects*; D018058:Tympanic Membrane Perforation / Q000139:chemically induced / Q000209:etiology*
chemical_list: D000305:Adrenal Cortex Hormones; D000893:Anti-Inflammatory Agents; D003907:Dexamethasone; D008775:Methylprednisolone