title: Kruppel-like Factors (KLFs) in muscle biology.
abstract: The Kruppel-like Factor (KLF) family of zinc-finger transcription factors are critical regulators of cell differentiation, phenotypic modulation and physiologic function. An emerging body of evidence implicates an important role for these factors in cardiovascular biology, however, the role of KLFs in muscle biology is only beginning to be understood. This article reviews the published data describing the role of KLFs in the heart, smooth muscle, and skeletal muscle and highlights the importance of these factors in cardiovascular development, physiology and disease pathobiology.
authors.affiliation: Case Cardiovascular Research Institute, Case Western Reserve University School of Medicine and University Hospitals of Cleveland / Case Medical Center, Cleveland, OH 44106, USA.
authors.forename: Saptarsi M
authors.initials: SM
authors.lastname: Haldar
authors.forename: Osama A
authors.initials: OA
authors.lastname: Ibrahim
authors.forename: Mukesh K
authors.initials: MK
authors.lastname: Jain
mesh_terms: D002318:Cardiovascular Diseases / Q000209:etiology; D006801:Humans; D051741:Kruppel-Like Transcription Factors / Q000145:classification / Q000502:physiology*; D018482:Muscle, Skeletal / Q000378:metabolism; D009130:Muscle, Smooth / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism
chemical_list: D051741:Kruppel-Like Transcription Factors