Possible novel receptor for PGD2 on human bronchial epithelial cells.
Prostaglandin D(2) (PGD(2)), a major prostanoid produced by activated mast cells, has long been implicated in allergic diseases. Recent studies have shown that PGD(2) exerts its effects through two different G-protein-coupled receptors (GPCRs), the D-prostanoid receptor (DP) and the chemoattractant receptor-homologous molecule expressed on T helper type-2 cells (CRTH2), expressed in various human tissues. The PGD(2)/CRTH2 system mediates the chemotaxis of eosinophils, basophils, and Th2 cells, which are involved in the induction of allergic inflammation. We have reported that normal human bronchial epithelial cells (NHBE) and epithelial cell lines (NCI-H(292)) expressed CRTH2, and PGD(2) induces production of IL-8 and GM-CSF. This review discusses the role of CRTH2/DP on epithelial cells and mentions a possible novel receptor for PGD(2).
Chiba
Takahito
T
Department of Clinical and Laboratory Medicine, Akita University School of Medicine, Akita, Japan.
Kanda
Akira
A
Ueki
Shigeharu
S
Ito
Wataru
W
Yamaguchi
Kazutoshi
K
Kamada
Yumiko
Y
Takeda
Masahide
M
Tanigai
Tomomi
T
Oyamada
Hajime
H
Kayaba
Hiroyuki
H
Chihara
Junichi
J
D001249:Asthma / Q000503:physiopathology; D001980:Bronchi / Q000166:cytology*; D001991:Bronchitis / Q000209:etiology / Q000503:physiopathology; D002460:Cell Line / Q000187:drug effects / Q000378:metabolism; D002633:Chemotaxis / Q000187:drug effects / Q000502:physiology; D004847:Epithelial Cells / Q000737:chemistry* / Q000187:drug effects / Q000502:physiology; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000096:biosynthesis; D006801:Humans; D016209:Interleukin-8 / Q000096:biosynthesis; D020935:MAP Kinase Signaling System / Q000187:drug effects; D009928:Organ Specificity; D015230:Prostaglandin D2 / Q000494:pharmacology / Q000502:physiology*; D012333:RNA, Messenger / Q000096:biosynthesis; D011971:Receptors, Immunologic / Q000819:agonists / Q000145:classification / Q000302:isolation & purification / Q000502:physiology*; D011982:Receptors, Prostaglandin / Q000819:agonists / Q000145:classification / Q000302:isolation & purification / Q000502:physiology*; D012130:Respiratory Hypersensitivity / Q000503:physiopathology; D018418:Th2 Cells / Q000276:immunology
D016209:Interleukin-8; D012333:RNA, Messenger; D011971:Receptors, Immunologic; D011982:Receptors, Prostaglandin; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D015230:Prostaglandin D2; C036293:prostaglandin D2 receptor