title: Quantification by magnetic resonance imaging and liver consequences of post-transfusional iron overload alone in long term survivors after allogeneic hematopoietic stem cell transplantation (HSCT).
abstract: We quantified and studied the impact of post transfusional iron overload alone in post allogeneic HSCT. Median number of RBCs was 18. Ferritin was 532 mg/L. Liver iron content (LIC) was 117 mmoles/gdw. Correlation RBCs and ferritin was (r=0.81); RBCs and LIC was (r=0.84). The high ferritin group differed from normal ferritin group in terms of RBCs transfused (p<10(-3)), ALT (p<0.009). But occurrence of liver dysfunction was not significant. Magnitude of iron overload correlates closely to the number of RBCs and is quantified by MRI. Impact on liver dysfunction is moderate in absence of co-morbidity.
authors.affiliation: Service d'Hématologie, Groupe Hospitalier de l'Institut CatholiqueService of Hemotherapy and Hemostasis, Hospital Clínic, Barcelona, Spain. Rose.Christian@ghicl.net
authors.forename: Christian
authors.initials: C
authors.lastname: Rose
authors.forename: Olivier
authors.initials: O
authors.lastname: Ernst
authors.forename: Bernard
authors.initials: B
authors.lastname: Hecquet
authors.forename: Patrice
authors.initials: P
authors.lastname: Maboudou
authors.forename: Pascale
authors.initials: P
authors.lastname: Renom
authors.forename: Marie Pierre
authors.initials: MP
authors.lastname: Noel
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Yakoub-Agha
authors.forename: Francis
authors.initials: F
authors.lastname: Bauters
authors.forename: Jean Pierre
authors.initials: JP
authors.lastname: Jouet
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D019190:Iron Overload / Q000175:diagnosis* / Q000209:etiology; D008107:Liver Diseases / Q000175:diagnosis / Q000209:etiology; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D017741:Survivors; D014184:Transplantation, Homologous