title: Airflow obstruction in young adults in Canada.
abstract: OBJECTIVE
  Airflow obstruction is relatively uncommon in young adults, and may indicate potential for the development of progressive disease. The objective of the present study was to enumerate and characterize airflow obstruction in a random sample of Canadians aged 20 to 44 years.
  
  
  METHODS
  The sample (n=2962) was drawn from six Canadian sites.
  
  
  METHODS
  A prevalence study using the European Community Respiratory Health Survey protocol was conducted. Airflow obstruction was assessed by spirometry. Bronchial responsiveness, skin reactivity to allergens and total serum immunoglobulin E were also measured. Logistic regression was used for analysis.
  
  
  RESULTS
  Airflow obstruction was observed in 6.4% of the sample, not associated with sex or age. The risk of airflow obstruction increased in patients who had smoked and in patients who had lung trouble during childhood. Adjusted for smoking, the risk of airflow obstruction was elevated for subjects with past and current asthma, skin reactivity to allergens, elevated levels of total immunoglobulin E and bronchial hyper-responsiveness. Of the subjects with airflow obstruction, 21% were smokers with a history of asthma, 50% were smokers without asthma, 12% were nonsmokers with asthma and 17% were nonsmokers with no history of asthma. Bronchial hyper-responsiveness increased the prevalence of airflow obstruction in each of these groups.
  
  
  CONCLUSIONS
  Smoking and asthma, jointly and individually, are major determinants of obstructive disorders in young adults. Bronchial hyper-responsiveness contributes to obstruction in both groups.
authors.affiliation: University of Manitoba, Winnipeg, Manitoba.
authors.forename: Manal
authors.initials: M
authors.lastname: Al-Hazmi
authors.forename: Kate
authors.initials: K
authors.lastname: Wooldrage
authors.forename: Nicholas R
authors.initials: NR
authors.lastname: Anthonisen
authors.forename: Margaret R
authors.initials: MR
authors.lastname: Becklake
authors.forename: Dennis
authors.initials: D
authors.lastname: Bowie
authors.forename: Moira
authors.initials: M
authors.lastname: Chan-Yeung
authors.forename: Helen
authors.initials: H
authors.lastname: Dimich-Ward
authors.forename: Pierre
authors.initials: P
authors.lastname: Ernst
authors.forename: Jure
authors.initials: J
authors.lastname: Manfreda
authors.forename: Malcolm R
authors.initials: MR
authors.lastname: Sears
authors.forename: Hans C
authors.initials: HC
authors.lastname: Siersted
authors.forename: Lamont
authors.initials: L
authors.lastname: Sweet
authors.forename: Linda
authors.initials: L
authors.lastname: Van Til
mesh_terms: D000328:Adult; D017677:Age Distribution; D001249:Asthma / Q000150:complications; D002170:Canada / Q000453:epidemiology; D005260:Female; D006306:Health Surveys; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D008173:Lung Diseases, Obstructive / Q000097:blood / Q000453:epidemiology* / Q000503:physiopathology; D008297:Male; D012129:Respiratory Function Tests; D012307:Risk Factors; D017678:Sex Distribution; D012907:Smoking / Q000009:adverse effects
chemical_list: D007073:Immunoglobulin E