[Optimization of preparation for matrine-loaded magnetic chitosan microspheres].
OBJECTIVE
To study the technique of preparation and optimization of magnetic chitosan microspheres.


METHODS
Magnetic fluid was produced by co-precipitation method and magnetic chitosan microspheres were produced using a convenient method of ionic gelation. A global optimization algorithm was used to optimize the parameters.


RESULTS
The formulated magenetic fluid and microspheres were characterized size and the size distribution. The average particle size of magnetic fluid and matrine-loaded chitosan magnetic microspheres were found to be 152.2 nm and 682.4 nm.


CONCLUSIONS
Global optimization algorithm is an efficient method to optimize the parameters.
Liu
Xiao-ping
XP
College of Chemical Engineering, Wuhan University of Technology, Wuhan 430070, China.
Wang
Ying
Y
Yan
Lie-xiang
LX
Shi
Bin
B
D000470:Alkaloids / Q000008:administration & dosage* / Q000737:chemistry; D002626:Chemistry, Pharmaceutical; D048271:Chitosan / Q000737:chemistry*; D004337:Drug Carriers; D008280:Magnetics; D008863:Microspheres; D010316:Particle Size; D011807:Quinolizines / Q000008:administration & dosage* / Q000737:chemistry; D012995:Solubility; D013678:Technology, Pharmaceutical / Q000379:methods; D000093842:Matrines
D000470:Alkaloids; D004337:Drug Carriers; D011807:Quinolizines; D048271:Chitosan; D000093842:Matrines