Influence of family history of type 2 diabetes on leptin concentration in cord blood of male offspring with high birth weight.
To verify whether a diabetes family history might be a risk factor for the development, in adult age, of metabolic disorders, leptin, anthropometric and endocrine parameters were analysed in 95 babies with grandparents affected by type 2 diabetes (DF) and in 95 matched babies without diabetes family history (NDF). A sexual dimorphism for leptin was present in the NDF group (males: 6.7+/-4.1 ng/ml; females: 12.3+/-6.5; p < 0.0001) but not in the DF group (males: 9.0+/-5.5; females: 10.8+/-6.4), due to the significant increase in DF male leptin level, compared to that of NDF males (p < 0.05). In DF males only, leptin was positively correlated with body length, PI, C-peptide, IGF-1 and IGF1BP3. These results suggest that the increase in DF male leptin could be a compensatory mechanism for reduced insulin sensitivity in a pre-clinical alteration of glucose metabolism.
Buongiorno
Angela Maria
AM
Dipartimento di Ematologia Oncologia e Medicina Molecolare, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy. angela.buongiorno@iss.it
Morelli
Stefania
S
Sagratella
Elisabetta
E
Sensi
Maurizio
M
Maroccia
Ettore
E
Caiola
Stefania
S
Vasta
Mario
M
D001724:Birth Weight; D001827:Body Height; D002096:C-Peptide / Q000032:analysis; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D020022:Genetic Predisposition to Disease; D006801:Humans; D007231:Infant, Newborn; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000235:genetics; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000097:blood; D007334:Insulin-Like Growth Factor I / Q000032:analysis; D007558:Italy / Q000453:epidemiology; D020738:Leptin / Q000097:blood*; D008297:Male; D012727:Sex Characteristics
D002096:C-Peptide; D007328:Insulin; D018972:Insulin-Like Growth Factor Binding Protein 3; D020738:Leptin; D007334:Insulin-Like Growth Factor I