title: Attenuation of allergic contact dermatitis through the endocannabinoid system.
abstract: Allergic contact dermatitis affects about 5% of men and 11% of women in industrialized countries and is one of the leading causes for occupational diseases. In an animal model for cutaneous contact hypersensitivity, we show that mice lacking both known cannabinoid receptors display exacerbated allergic inflammation. In contrast, fatty acid amide hydrolase-deficient mice, which have increased levels of the endocannabinoid anandamide, displayed reduced allergic responses in the skin. Cannabinoid receptor antagonists exacerbated allergic inflammation, whereas receptor agonists attenuated inflammation. These results demonstrate a protective role of the endocannabinoid system in contact allergy in the skin and suggest a target for therapeutic intervention.
authors.affiliation: Department of Molecular Psychiatry, University of Bonn, Germany.
authors.forename: Meliha
authors.initials: M
authors.lastname: Karsak
authors.forename: Evelyn
authors.initials: E
authors.lastname: Gaffal
authors.forename: Rahul
authors.initials: R
authors.lastname: Date
authors.forename: Lihua
authors.initials: L
authors.lastname: Wang-Eckhardt
authors.forename: Jennifer
authors.initials: J
authors.lastname: Rehnelt
authors.forename: Stefania
authors.initials: S
authors.lastname: Petrosino
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Starowicz
authors.forename: Regina
authors.initials: R
authors.lastname: Steuder
authors.forename: Eberhard
authors.initials: E
authors.lastname: Schlicker
authors.forename: Benjamin
authors.initials: B
authors.lastname: Cravatt
authors.forename: Raphael
authors.initials: R
authors.lastname: Mechoulam
authors.forename: Reinhard
authors.initials: R
authors.lastname: Buettner
authors.forename: Sabine
authors.initials: S
authors.lastname: Werner
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Di Marzo
authors.forename: Thomas
authors.initials: T
authors.lastname: Tüting
authors.forename: Andreas
authors.initials: A
authors.lastname: Zimmer
mesh_terms: D000818:Animals; D001095:Arachidonic Acids / Q000378:metabolism; D001892:Camphanes / Q000008:administration & dosage / Q000494:pharmacology; D063385:Cannabinoid Receptor Modulators / Q000502:physiology*; D002186:Cannabinoids / Q000008:administration & dosage / Q000494:pharmacology; D018925:Chemokines / Q000502:physiology; D017449:Dermatitis, Allergic Contact / Q000473:pathology / Q000503:physiopathology*; D004139:Dinitrofluorobenzene; D004195:Disease Models, Animal; D015536:Down-Regulation; D013759:Dronabinol / Q000008:administration & dosage / Q000494:pharmacology; D063388:Endocannabinoids; D005260:Female; D005989:Glycerides / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D020411:Oligonucleotide Array Sequence Analysis; D010880:Piperidines / Q000008:administration & dosage / Q000494:pharmacology; D053284:Polyunsaturated Alkamides / Q000378:metabolism; D011720:Pyrazoles / Q000008:administration & dosage / Q000494:pharmacology; D043884:Receptor, Cannabinoid, CB1 / Q000819:agonists / Q000037:antagonists & inhibitors / Q000235:genetics / Q000502:physiology*; D043885:Receptor, Cannabinoid, CB2 / Q000819:agonists / Q000037:antagonists & inhibitors / Q000235:genetics / Q000502:physiology*; D000077285:Rimonabant; D012867:Skin / Q000378:metabolism* / Q000473:pathology; D015854:Up-Regulation
chemical_list: D001095:Arachidonic Acids; D001892:Camphanes; D063385:Cannabinoid Receptor Modulators; D002186:Cannabinoids; D018925:Chemokines; D063388:Endocannabinoids; D005989:Glycerides; D010880:Piperidines; D053284:Polyunsaturated Alkamides; D011720:Pyrazoles; D043884:Receptor, Cannabinoid, CB1; D043885:Receptor, Cannabinoid, CB2; C110630:SR 144528; D013759:Dronabinol; C094503:glyceryl 2-arachidonate; C402416:HU 308; D004139:Dinitrofluorobenzene; D000077285:Rimonabant; C078814:anandamide