title: Good efficiency of intrauterine insemination programme for serodiscordant couples with HIV-1 infected male partner: a retrospective comparative study.
abstract: OBJECTIVE
  Assisted reproduction techniques can minimize the risk of HIV female contamination when the male partner is HIV-infected. The aim of this study was to investigate the efficiency of sperm washing and intrauterine insemination (IUI) in these couples.
  
  
  METHODS
  Retrospective comparative study. Eighty-four HIV-1 serodicordant couples underwent 294 IUI. The control group was composed of 90 couples (320 IUI cycles) with donor sperm. Spermatozoa from HIV-1 infected male partner were prepared and tested for HIV-1 according to sperm washing method. Spermatozoa from HIV-1 and donor male were frozen before IUI. IUI were performed after ovarian stimulation. Main outcomes measures were pregnancy rate per cycle and baby take-home rate per couples.
  
  
  RESULTS
  Although the pregnancy rate and baby take-home rate were higher in IUI with sperm washing than in IUI using donor sperm (18.0 versus 14.7 and 52.4 versus 41.1, respectively), the differences were not statistically significant. In serodiscordant couples, blood estradiol levels under ovarian stimulation and total motile sperm inseminated were a determining factor in achieving pregnancy. No female HIV-1 contamination occurred.
  
  
  CONCLUSIONS
  This study demonstrates that sperm washing and IUI are highly effective in enabling serodiscordant couples with an HIV-1 infected male partner to have a child.
authors.affiliation: Université Toulouse-III Paul Sabatier, EA 3694, Research Group on Human Fertility, France. bujan.l@chu-toulouse.fr
authors.forename: Louis
authors.initials: L
authors.lastname: Bujan
authors.forename: Martin
authors.initials: M
authors.lastname: Sergerie
authors.forename: Nicolas
authors.initials: N
authors.lastname: Kiffer
authors.forename: Nathalie
authors.initials: N
authors.lastname: Moinard
authors.forename: Geneviève
authors.initials: G
authors.lastname: Seguela
authors.forename: Brigitte
authors.initials: B
authors.lastname: Mercadier
authors.forename: Pascale
authors.initials: P
authors.lastname: Rhone
authors.forename: Christophe
authors.initials: C
authors.lastname: Pasquier
authors.forename: Myriam
authors.initials: M
authors.lastname: Daudin
mesh_terms: D000328:Adult; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000517:prevention & control*; D015497:HIV-1; D006801:Humans; D007316:Insemination, Artificial, Heterologous / Q000379:methods*; D008297:Male; D011247:Pregnancy; D018873:Pregnancy Rate; D012189:Retrospective Studies; D013094:Spermatozoa / Q000821:virology*