title: Synthesis and evaluation of potent and selective beta3 adrenergic receptor agonists containing heterobiaryl carboxylic acids.
abstract: The design, synthesis, and SAR of a novel series of heterobiaryl phenethanolamine beta3 adrenergic receptor agonists are described. The furan analogue 49 was shown to elicit a significant dose-dependent lowering of plasma glucose in a rodent model of type 2 diabetes.
authors.affiliation: Department of Medicinal Chemistry, GlaxoSmithKline, Research Triangle Park, NC 27709, USA. barry.g.shearer@gsk.com
authors.forename: Barry G
authors.initials: BG
authors.lastname: Shearer
authors.forename: Esther Y
authors.initials: EY
authors.lastname: Chao
authors.forename: David E
authors.initials: DE
authors.lastname: Uehling
authors.forename: David N
authors.initials: DN
authors.lastname: Deaton
authors.forename: Conrad
authors.initials: C
authors.lastname: Cowan
authors.forename: Bryan W
authors.initials: BW
authors.lastname: Sherman
authors.forename: Tula
authors.initials: T
authors.lastname: Milliken
authors.forename: Walter
authors.initials: W
authors.lastname: Faison
authors.forename: Kathleen
authors.initials: K
authors.lastname: Brown
authors.forename: Kimberly K
authors.initials: KK
authors.lastname: Adkison
authors.forename: Frank
authors.initials: F
authors.lastname: Lee
mesh_terms: D058667:Adrenergic beta-3 Receptor Agonists; D001665:Binding Sites; D002264:Carboxylic Acids / Q000737:chemistry* / Q000494:pharmacology*; D008958:Models, Molecular; D015394:Molecular Structure; D013329:Structure-Activity Relationship
chemical_list: D058667:Adrenergic beta-3 Receptor Agonists; D002264:Carboxylic Acids