title: [Analysis of the mode of inheritance for distichiasis in the Elo dog breed using complex segregation analyses].
abstract: The inheritance of distichiasis was analyzed in the dog breed Elo using complex segregation analyses. The different hypotheses of monogenic, mixed-monogenic-polygenic and polygenic inheritance as well as a pure environmental model were tested. In further analyses the number of examined Elo dogs per ophthalmologist and the proportion of genes of Eurasian and Old English Sheepdogs were included in the models as covariates. Seven families were randomly collected for the analyses. The seven families comprised a total of 296 animals with 218 examined and 65 affected dogs. A genetic component was verified for the prevalence of distichiasis. Mixed models with a recessive, dominant or arbitrary major gene effect and the polygenic model represented likely hypotheses of inheritance. The prevalence of distichiasis observed was insufficiently explained by non-genetic factors and the breed composition. Therefore, a model only including non-genetic factors and the breed composition could be excluded.
authors.affiliation: Institut für Tierzucht und Vererbungsforschung der Stiftung Tierärztliche Hochschule Hannover.
authors.forename: Judith
authors.initials: J
authors.lastname: Kaufhold
authors.forename: Henning
authors.initials: H
authors.lastname: Hamann
authors.forename: Gudrun
authors.initials: G
authors.lastname: Steinbach
authors.forename: Sabine
authors.initials: S
authors.lastname: Gordon
authors.forename: Rolf
authors.initials: R
authors.lastname: Brahm
authors.forename: Heinrich
authors.initials: H
authors.lastname: Grussendorf
authors.forename: Carsten U
authors.initials: CU
authors.lastname: Rosenhagen
authors.forename: Ottmar
authors.initials: O
authors.lastname: Distl
mesh_terms: D000818:Animals; D001947:Breeding; D004283:Dog Diseases / Q000235:genetics*; D004285:Dogs; D005140:Eyelashes / Q000002:abnormalities*; D005141:Eyelid Diseases / Q000235:genetics / Q000662:veterinary*; D005260:Female; D040582:Inheritance Patterns / Q000235:genetics*; D016015:Logistic Models; D008297:Male; D008957:Models, Genetic; D010375:Pedigree