Synthesis, antifungal and antimicrobial activity of alkylphospholipids.
The antifungal, antibacterial and haemolytic activity of a series of alkylphosphocholines (e.g., miltefosine) and alkylglycerophosphocholines (e.g., edelfosine) has been investigated. These compound classes exhibit significant antifungal and moderate antibacterial activities. Several new alkylphosphocholine derivatives with amide or ester bonds in the alkyl chain have been synthesised. These compounds show much lower haemolytic activity than miltefosine. Alkylphosphocholines and alkylglycerophosphocholines show significant promise as novel orally available antifungal and antibacterial therapeutics.
Obando
Daniel
D
School of Chemistry, The University of Sydney, NSW, Australia.
Widmer
Fred
F
Wright
Lesley C
LC
Sorrell
Tania C
TC
Jolliffe
Katrina A
KA
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D004912:Erythrocytes / Q000187:drug effects; D005658:Fungi / Q000187:drug effects; D015394:Molecular Structure; D010743:Phospholipids / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D010743:Phospholipids