title: Insertional mutagenesis to generate lantibiotic resistance in Lactococcus lactis.
abstract: While the potential emergence of food spoilage and pathogenic bacteria with resistance to lantibiotics is a concern, the creation of derivatives of starter cultures and adjuncts that can grow in the presence of these antimicrobials may have applications in food fermentations. Here a bank of Lactococcus lactis IL1403 mutants was created and screened, and a number of novel genetic loci involved in lantibiotic resistance were identified.
authors.affiliation: Department of Microbiology, University College Cork, Cork, Ireland.
authors.forename: Caitriona M
authors.initials: CM
authors.lastname: Guinane
authors.forename: Paul D
authors.initials: PD
authors.lastname: Cotter
authors.forename: Elaine M
authors.initials: EM
authors.lastname: Lawton
authors.forename: Colin
authors.initials: C
authors.lastname: Hill
authors.forename: R Paul
authors.initials: RP
authors.lastname: Ross
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001430:Bacteriocins / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D013294:Lactococcus lactis / Q000187:drug effects* / Q000235:genetics*; D016254:Mutagenesis, Insertional
chemical_list: D000900:Anti-Bacterial Agents; D001430:Bacteriocins