Statins do not improve short-term survival in an oriental population with sepsis.
OBJECTIVE
The aim of this study was to define the effect of statin on 30-day mortality in an oriental population with sepsis.


METHODS
We conducted a retrospective study on patients with sepsis at National Taiwan University Hospital from 2001 to 2002. The effects of statins on 30-day mortality were evaluated based on clinical settings. Log-rank test and Cox regression analysis were performed using the proportional hazards assumption.


RESULTS
A total of 763 episodes of sepsis were reviewed; 454 consecutive patients were considered eligible. Among them, 104 (22.9%) took a statin at least 30 days before admission and during sepsis course, whereas the other 350 control (77.1%) did not. There was no significant difference of 30-day sepsis-related mortality between groups (19.2% vs 18.9%, P = .952). Statin treatment was not associated with decreased mortality at 30 days (P = .853; risk ratio, 0.95; 95% confidence interval, 0.53-1.68).


CONCLUSIONS
Short-term, sepsis-related mortality in a septic Taiwanese population was not reduced with statin treatment in our study. We concluded that statin therapy may have little effect on the survival of sepsis in oriental people, particularly in Taiwanese.
Yang
Kai-Chien
KC
Division of Cardiology, Department of Internal Medicine, E-Da Hospital, Kaohsiung, Taiwan.
Chien
Jung-Yien
JY
Tseng
Wei-Kung
WK
Hsueh
Po-Ren
PR
Yu
Chong-Jen
CJ
Wu
Chau-Chung
CC
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D018805:Sepsis / Q000188:drug therapy* / Q000401:mortality*; D018709:Statistics, Nonparametric; D016019:Survival Analysis; D013624:Taiwan / Q000453:epidemiology
D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors