Nerve growth factor and tissue repair remodeling: trkA(NGFR) and p75(NTR), two receptors one fate.
This review deals with the role of nerve growth factor (NGF) in healing process as a result of injury. The role of both trkA(NGFR) and p75(NTR) specific NGF receptors and their contribution in the complex network of tissue repair process, is discussed and highlighted in view of recent findings. In fact, NGF represents a significant advance in the treatment of etiologically different ulcers (corneal ulcers, pressure ulcers, post-viral infections, chemical burns) and might shorten the recovery process. For these diseases, no specific treatment is actually available. It is reasonable that apart from NGF and/or neurotrophins a different time-course of trkA(NGRF)/p75(NTR) expression, might regulate the final process. In summary, these novel findings on the potential pro-healing capacity of NGF might open new possibilities for this growth factor in modulating the healing processes in several pathological conditions.
Micera
Alessandra
A
Department of Pharmacology, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Israel.
Lambiase
Alessandro
A
Stampachiacchiere
Barbara
B
Bonini
Stefano
S
Bonini
Sergio
S
Levi-Schaffer
Francesca
F
D000818:Animals; D005355:Fibrosis; D006801:Humans; D006967:Hypersensitivity; D007249:Inflammation; D036341:Intercellular Signaling Peptides and Proteins; D008954:Models, Biological; D020932:Nerve Growth Factor / Q000378:metabolism*; D009414:Nerve Growth Factors / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D020917:Receptor, trkA / Q000378:metabolism*; D017475:Receptors, Nerve Growth Factor / Q000378:metabolism*; D015398:Signal Transduction; D014158:Transcription, Genetic; D014456:Ulcer / Q000628:therapy; D014945:Wound Healing
D036341:Intercellular Signaling Peptides and Proteins; C484065:NGFR protein, human; D009414:Nerve Growth Factors; D009419:Nerve Tissue Proteins; D017475:Receptors, Nerve Growth Factor; D020932:Nerve Growth Factor; D020917:Receptor, trkA