title: The g.243A>G mutation in intron 17 of MUC4 is significantly associated with susceptibility/resistance to ETEC F4ab/ac infection in pigs.
abstract: Using a porcine radiation hybrid panel, we assigned the mucin 4 (MUC4) gene to SSC13q41, which harbours the enterotoxigenic Escherichia coli (ETEC) F4ab/ac receptor locus. In addition, we identified two SNPs in intron 17 of MUC4 (DQ124298:g.243A>G and DQ124298:g.334A>G) in the parental population of a White Duroc x Erhualian cross. Association analysis showed that the MUC4 g.243A>G mutation was strongly associated with ETEC F4ab/ac, and especially with F4ac adhesion phenotypes in the White Duroc x Erhualian resource population, indicating that this polymorphism was in a significant linkage disequlibrium with the ETEC F4ab/ac receptor locus. Because of different linkage disequlibrium values between the ETEC F4ab and F4ac adhesion phenotypes and the MUC4 g.243A>G mutation, we argue that the inheritance of F4ab and F4ac receptors might be under the control of two closely linked loci.
authors.affiliation: Key Laboratory for Animal Biotechnology of Jiangxi Province and the Ministry of Agriculture of China, Jiangxi Agricultural University, 330045, Nanchang, China.
authors.forename: Q-L
authors.initials: QL
authors.lastname: Peng
authors.forename: J
authors.initials: J
authors.lastname: Ren
authors.forename: X-M
authors.initials: XM
authors.lastname: Yan
authors.forename: X
authors.initials: X
authors.lastname: Huang
authors.forename: H
authors.initials: H
authors.lastname: Tang
authors.forename: Y-Z
authors.initials: YZ
authors.lastname: Wang
authors.forename: B
authors.initials: B
authors.lastname: Zhang
authors.forename: L-S
authors.initials: LS
authors.lastname: Huang
mesh_terms: D000818:Animals; D004927:Escherichia coli Infections / Q000235:genetics / Q000662:veterinary*; D005260:Female; D007113:Immunity, Innate / Q000235:genetics; D007438:Introns; D015810:Linkage Disequilibrium; D008297:Male; D055264:Mucin-4; D009077:Mucins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D021101:Radiation Hybrid Mapping; D013552:Swine; D013553:Swine Diseases / Q000235:genetics*
chemical_list: D055264:Mucin-4; D009077:Mucins