Bioactive phenolic compounds from aerial parts of Plinia glomerata.
The present work describes the antinociceptive properties and chemical composition of the aerial parts of Plinia glomerata (Myrtaceae). Both of the extracts evaluated, acetonic and methanolic, showed potent antinociceptive action, when analyzed against acetic acid-induced abdominal constrictions in mice, with calculated ID50 (mg/kg, i. p.) values of 24.8 and 3.3, respectively. Through usual chromatographic techniques with an acetonic extract, the following compounds were obtained: 3,4,3'-trimethoxy flavellagic acid (1), 3,4,3'-trimethoxy flavellagic acid 4'-O-glucoside (3) and quercitrin (4), which were identified based on spectroscopic data. Compounds 1 (ID50 = 3.9 mg/kg, i. p., or 10.8 micromol/kg) and 3 (ID50 = 1.3 mg/kg or 2.5 micromol/kg) were notably more active than some well-known analgesic drugs used here for comparison.
Serafin
Cláudia
C
Programa de Mestrado em Ciências Farmacêuticas e Núcleo de Investigações Químico-Farmacêuticas (NIQFAR), Universidade do Vale do Itajaí (UNIVALI), Itajaí, 88302-202 Santa Catarina, Brazil.
Nart
Viviane
V
Malheiros
Angela
A
de Souza
Márcia Maria
MM
Fischer
Luiz
L
Delle Monache
Giuliano
G
Della Monache
Franco
F
Cechinel Filho
Valdir
V
D000082:Acetaminophen / Q000494:pharmacology; D000700:Analgesics / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D001241:Aspirin / Q000494:pharmacology; D001938:Brazil; D004008:Diclofenac / Q000494:pharmacology; D004177:Dipyrone / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D008958:Models, Molecular; D027822:Myrtaceae / Q000737:chemistry*; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D035261:Plant Components, Aerial / Q000737:chemistry*
D000700:Analgesics; D010636:Phenols; D004008:Diclofenac; D000082:Acetaminophen; D004177:Dipyrone; D001241:Aspirin