[Effect of incretin hormones GIP and GLP-1 for the pathogenesis of type 2 diabetes mellitus].
Oral administration of glucose stimulates insulin secretion to a greater extent than does glucose administered as an isoglycaemic intravenous glucose infusion. This phenomenon is called the incretin effect and is caused by the two incretin hormones GIP and GLP-1. In patients with type 2 diabetes, the incretin effect is impaired. The mechanisms of the impaired incretin effect have been found to involve reduced secretion of GLP-1 and a severely impaired effect of GIP. It is currently unknown whether these defects are consequences of the diabetic state or primary pathogenetic factors.
Vilsbøll
Tina
T
Gentofte Hospital, Medicinsk Afdeling F, Hellerup. t.vilsboll@dadlnet.dk
Knop
Filip Krag
FK
D003924:Diabetes Mellitus, Type 2 / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology; D005749:Gastric Inhibitory Polypeptide / Q000378:metabolism / Q000502:physiology*; D052216:Glucagon-Like Peptide 1 / Q000378:metabolism*; D005947:Glucose / Q000008:administration & dosage / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D052336:Proglucagon / Q000378:metabolism
D007328:Insulin; D052336:Proglucagon; D005749:Gastric Inhibitory Polypeptide; D052216:Glucagon-Like Peptide 1; D005947:Glucose