Prostaglandin E2 and interleukin-8 production in human epidermal keratinocytes exposed to marine lipid-based liposomes.
In response to exogenous stimuli such as non-sensitizing contact irritants, human keratinocytes produce various types of soluble pro-inflammatory mediators including prostaglandin E2 (PGE2) and interleukin 8 (IL-8). Polyunsaturated fatty acids of the n-3 series (n-3 PUFA) are known to play a role in the prevention of the inflammatory response. In this work, n-3 PUFA were supplied to keratinocytes through Marinosomes that are liposomes based on a natural marine lipid extract. Marinosomes contributed to reduce inflammation induced by croton oil by regulating PGE2 and IL-8 production in human keratinocyte cultures. However, the preventing effect of Marinosomes was highly dependent on the lipid concentration used and the liposome mean diameter.
Cansell
Maud S
MS
Université Bordeaux 1, Laboratoire Milieux Dispersés Alimentaires, ISTAB, 33405 Talence Cedex, France. m.cansell@istab.u-bordeaux1.fr
Moussaoui
N
N
Mancini
M
M
D000893:Anti-Inflammatory Agents / Q000008:administration & dosage* / Q000494:pharmacology; D002478:Cells, Cultured; D015232:Dinoprostone / Q000378:metabolism*; D000078404:Epidermal Cells; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage* / Q000494:pharmacology; D006801:Humans; D016209:Interleukin-8 / Q000378:metabolism*; D015603:Keratinocytes / Q000187:drug effects* / Q000378:metabolism; D008081:Liposomes
D000893:Anti-Inflammatory Agents; D015525:Fatty Acids, Omega-3; D016209:Interleukin-8; D008081:Liposomes; D015232:Dinoprostone