title: Cytogenetic aberrations in neuropathy associated with IgM monoclonal gammopathy.
abstract: The occurrence and nature of cytogenetic aberrations in polyneuropathy associated with IgM monoclonal gammopathy was determined. Therefore, interphase fluorescence in situ hybridization (FISH) was applied in 22 patients with polyneuropathy associated with IgM monoclonal gammopathy, multiplex ligation-dependent probe amplification (MLPA) assay in 18 of these patients and genome-wide-array-based comparative genomic hybridization (CGH) in eight of these 18 patients. Four patients had 10-20% and one patient had 30% B cells with IgH rearrangements; one patient had additional loss of 14qter; one patient had amplification of 6p and loss of 6q. Cytogenetic aberrations may be found in one third of the patients with neuropathy associated with IgM monoclonal gammopathy and are mainly associated with indolent Waldenstrom's Macroglobulinemia.
authors.affiliation: Department of Neurology, the Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, The Netherlands. m.eurelings@neuro.azu.nl
authors.forename: Marijke
authors.initials: M
authors.lastname: Eurelings
authors.forename: Henk M
authors.initials: HM
authors.lastname: Lokhorst
authors.forename: Nicolette C
authors.initials: NC
authors.lastname: Notermans
authors.forename: Pieter Jaap
authors.initials: PJ
authors.lastname: Krijtenburg
authors.forename: Berris van
authors.initials: Bv
authors.lastname: Kessel
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Eleveld
authors.forename: Andries
authors.initials: A
authors.lastname: Bloem
authors.forename: John H
authors.initials: JH
authors.lastname: Wokke
authors.forename: Martin
authors.initials: M
authors.lastname: Poot
authors.forename: Arjan
authors.initials: A
authors.lastname: Buijs
mesh_terms: D000368:Aged; D001402:B-Lymphocytes / Q000276:immunology; D002869:Chromosome Aberrations; D002883:Chromosomes, Human, Pair 14 / Q000235:genetics*; D004252:DNA Mutational Analysis; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005820:Genetic Testing; D005838:Genotype; D006801:Humans; D007075:Immunoglobulin M / Q000235:genetics* / Q000276:immunology; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D008875:Middle Aged; D010265:Paraproteinemias / Q000235:genetics* / Q000276:immunology / Q000503:physiopathology; D010525:Peripheral Nerves / Q000276:immunology / Q000503:physiopathology; D011115:Polyneuropathies / Q000235:genetics* / Q000276:immunology / Q000503:physiopathology; D008258:Waldenstrom Macroglobulinemia / Q000235:genetics / Q000276:immunology / Q000503:physiopathology
chemical_list: D007075:Immunoglobulin M