title: Role of magnification endoscopy in the diagnosis and evaluation of suspected celiac disease: correlation with histology.
abstract: BACKGROUND
  Magnification endoscopy (ME), with 115-fold magnification, allows visualization of duodenal villi. We assessed the efficacy of ME for evaluation of villous atrophy.
  
  
  METHODS
  ME and duodenal biopsy were done in 16 patients with suspected celiac disease and 16 control subjects undergoing endoscopy for reflux symptoms. The pathologist was unaware of the ME findings.
  
  
  RESULTS
  Sensitivity, specificity and positive and negative predictive values for villous atrophy (partial or total) were 100%, 91%, 83% and 100%, respectively. Corresponding values for normal villous structure were 91%, 100%, 100% and 83%, respectively. There was significant concordance between the ME and histology findings.
  
  
  CONCLUSIONS
  ME is a reliable technique to diagnose villous atrophy.
authors.affiliation: Department of Gastroenterology, Asian Institute of Gastroenterology, Hyderabad, India.
authors.forename: Rupa
authors.initials: R
authors.lastname: Banerjee
authors.forename: Anuradha
authors.initials: A
authors.lastname: Shekharan
authors.forename: C
authors.initials: C
authors.lastname: Ramji
authors.forename: Srinivas R
authors.initials: SR
authors.lastname: Puli
authors.forename: Rakesh
authors.initials: R
authors.lastname: Kalapala
authors.forename: Mohan
authors.initials: M
authors.lastname: Ramachandani
authors.forename: Rajesh
authors.initials: R
authors.lastname: Gupta
authors.forename: Sandeep
authors.initials: S
authors.lastname: Lakhtakia
authors.forename: Manu
authors.initials: M
authors.lastname: Tandan
authors.forename: G V
authors.initials: GV
authors.lastname: Rao
authors.forename: D Nageshwar
authors.initials: DN
authors.lastname: Reddy
mesh_terms: D000328:Adult; D001284:Atrophy; D001706:Biopsy; D002446:Celiac Disease / Q000175:diagnosis* / Q000473:pathology; D004384:Duodenoscopy / Q000379:methods*; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007413:Intestinal Mucosa / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity