A Comparison of the Therapeutic Plan Costs in the Treatment of HIV-Positive Patients.
OBJECTIVE
To determine the cost of each therapeutic protocol (TP) used for HIV-positive patients and to identify the most frequently adopted one by relating it to the cost and by identifying the drug (drugs) that is more competitive in relation to expense.


METHODS
Infectious Disease Department and Hospital Pharmacy, Ospedale Maggiore, Bologna, Italy. The department treats approximately 600 outpatients with HIV infection each year.


METHODS
464 patients with HIV infection were examined every 3 months and clinicians judged whether the treatment (usually consisting of three drugs) was to be continued or changed according to its effectiveness, availability and possible new treatment options. The study also ascertained the cost of antiretroviral drugs within the period 1 January 2001-30 April 2002, and identified the most commonly used therapeutic protocols, the relevant daily cost and the frequency of use in all patients. The cost of the various protocols (most TPs were grouped in the most frequently used 15 regimens) was considered only at the end of the study, in order to define the percentage differences in cost. Importantly, from the beginning, this aspect was not a primary factor in drug choice.


RESULTS
The antiretroviral drug cost was 4 448 186 Euro (euro) in 2001 and euro1 536 984 in the first 4 months of 2002, with an increase of 3.5% compared with the same period in 2001. In the 16 months under consideration, 55.21% of the cost was associated with nucleoside reverse transcriptase inhibitors (NRTI), 25.97% with protease inhibitors (PI) and 18.83% with non-nucleoside reverse transcriptase inhibitors (NNRTI). Among the 464 TPs considered, 331 (71.33%) were distributed among 15 prevalent TPs. The least expensive TP (euro9.95/day; time of costing 1 January 2001-30 April 2002) comprised two drugs (stavudine and lamivudine) and showed a cost differential of +euro16.74 (+62.70%) compared with the most expensive one (zidovudine, lamivudine, lopinavir and ritonavir). The most used TP (zidovudine, lamivudine and nevirapine) covered 61 cases (13.1%) with a daily cost of euro19.61 (time of costing 1 January 2001-30 April 2002).


CONCLUSIONS
This study demonstrated that, starting with decisions that take into account the efficacy of the therapy and the compliance of the patients, and choosing ethical protocols agreed upon with the patients, it is possible to reduce the costs of the TPs. Of the 464 TPs examined, NNRTIs were used in 46.7% of the cases and a PI in 39.6% (16.1% of the latter drug group was boosted with ritonavir). Only 7% of TPs used two drugs (NRTIs). The two less expensive TPs comprised two drugs only (NRTIs). Among the three-drug TPs with a lower cost, the drug pattern was two NRTIs and one NNRTI. The remaining TPs included a PI as a third drug and demonstrated a cost increase greater than 50% with respect to the less expensive treatment.
Sabbatani
S
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Unità Operativa Malattie Infettive, Ospedale Maggiore, Bologna, Italy.