NPY mediates basal and seizure-induced proliferation in the subcallosal zone.
Stem cell niches exist around the lateral ventricle and in the subgranular layer of the dentate gyrus, supporting adult neurogenesis. Recently, a third germinal layer, the subcallosal zone has been identified supporting the generation of oligodendrocytes in the adult brain. We have previously described a proliferative role for neuropeptide Y on precursors in the dentate gyrus, caudal subventricular zone and subcallosal zone under basal conditions and in the dentate gyrus after seizures. Here we sought to determine a role for neuropeptide Y in seizure-induced proliferation in the subcallosal niche. Using the chemoconvulsant kainate and neuropeptide Y(-/-) mice with controls, we show an effect of neuropeptide Y on basal proliferation and demonstrate a significant reduction in seizure-induced proliferation in the subcallosal zone.
Laskowski
Alexandra
A
Division of Clinical Neurosciences, University of Southampton, UK.
Howell
Owain W
OW
Sosunov
Alexander A
AA
Sosuov
Alexander A
AA
McKhann
Guy
G
Gray
William P
WP
D000704:Analysis of Variance; D000818:Animals; D001973:Bromodeoxyuridine / Q000378:metabolism; D002452:Cell Count / Q000379:methods; D049109:Cell Proliferation / Q000187:drug effects; D006624:Hippocampus / Q000473:pathology*; D007608:Kainic Acid; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D009478:Neuropeptide Y / Q000172:deficiency / Q000502:physiology*; D038081:Organogenesis / Q000502:physiology; D012640:Seizures / Q000139:chemically induced / Q000473:pathology* / Q000503:physiopathology*
D009478:Neuropeptide Y; D001973:Bromodeoxyuridine; D007608:Kainic Acid