title: [Phase IIa clinical trail of hemocoagulase acutus for injection].
abstract: OBJECTIVE
  To evaluate the efficacy and safety of hemocoagulase acutus for injection and determine its curative dose.
  
  
  METHODS
  Forty-five patients on abdominal surgeries were randomly allocated into 2 study groups and 1 control group. Thirty minutes before the operation, the patients in the study groups received intravenous hemocoagulase acutus at 1 U and 2 U, respectively, and control group had no treatment. The hemostatic time, hemorrhagic volume, and hemoagglutination were observed in all the groups.
  
  
  RESULTS
  The average hemorrhagic volume and hemorrhagic volume per square were significantly lower in the two study groups than in the control group (P<0.05), and the average hemorrhagic volume per square were significantly lower in study group 2 U than in the 1 U group (P<0.05). No significant differences were found in adverse effects between the 3 groups.
  
  
  CONCLUSIONS
  Hemocoagulase acutus for injection has good hemostatic effect for controlling capillary hemorrhage at the abdominal incisions and can be safely used in the surgical patients.
authors.affiliation: Department of General Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China. tiandansun@21cn.com
authors.forename: Jun-jie
authors.initials: JJ
authors.lastname: Zhou
authors.forename: Zong-hai
authors.initials: ZH
authors.lastname: Huang
authors.forename: Jin-long
authors.initials: JL
authors.lastname: Yu
authors.forename: Zhou
authors.initials: Z
authors.lastname: Li
authors.forename: Guang-jun
authors.initials: GJ
authors.lastname: Zhou
mesh_terms: D000005:Abdomen / Q000601:surgery*; D000293:Adolescent; D000328:Adult; D000368:Aged; D017836:Agkistrodon / Q000378:metabolism; D000818:Animals; D012103:Batroxobin / Q000008:administration & dosage / Q000627:therapeutic use*; D001777:Blood Coagulation / Q000187:drug effects*; D016063:Blood Loss, Surgical / Q000517:prevention & control; D006488:Hemostasis, Surgical / Q000379:methods*; D006490:Hemostatics / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D006490:Hemostatics; D012103:Batroxobin