title: Aortic root reconstruction with a bioprosthetic valved conduit: a consecutive series of 275 procedures.
abstract: OBJECTIVE
  The study objective was to assess the results of aortic root reconstruction using composite conduits with stented bioprosthetic valves.
  
  
  METHODS
  A review was conducted of 275 patients (202 were male, mean age 69 +/- 11 years, range 17-88 years) who underwent aortic root replacement using conduits constructed intraoperatively from pericardial valves and impregnated Dacron grafts between September 1993 and February 2005. There were 151 patients with degenerative aneurysms and 63 patients with atherosclerotic aneurysms; 43 patients had dissections (9 acute type A), 13 patients had endocarditis, and 5 patients had other pathologic conditions. The ascending aorta alone was replaced in 154 patients, a hemiarch reconstruction was performed in 105 patients, and extensive arch reconstruction was performed in 16 patients. Hypothermic circulatory arrest and an open distal anastomosis were used in 95% of patients.
  
  
  RESULTS
  Hospital mortality was 17 of 275 patients (6.2%). Four additional patients (1.5%) sustained permanent strokes. Among surviving patients, the rate of stroke was estimated as 0.85 per 100 patient-years and the rate of significant hemorrhage was estimated as 0.3 per 100 patient-years. Reoperation for valve failure occurred in only 1 patient 12 years postoperatively. Long-term survival in men was similar to that of a normal matched control population, but was significantly lower in women (P = .002).
  
  
  CONCLUSIONS
  Men who recover satisfactorily after reconstruction of the aortic root with a stented bioprosthetic valved conduit (6-month survivors) enjoy long-term outcomes equivalent to that of a normal matched population; the postoperative mortality rate in women is twice that of a normal population.
authors.affiliation: Department of Cardiothoracic Surgery, Mount Sinai School of Medicine, New York, NY 10029, USA. christian.etz@mountsinai.org
authors.forename: Christian D
authors.initials: CD
authors.lastname: Etz
authors.forename: Tobias M
authors.initials: TM
authors.lastname: Homann
authors.forename: Neil
authors.initials: N
authors.lastname: Rane
authors.forename: Carol A
authors.initials: CA
authors.lastname: Bodian
authors.forename: Gabriele
authors.initials: G
authors.lastname: Di Luozzo
authors.forename: Konstadinos A
authors.initials: KA
authors.lastname: Plestis
authors.forename: David
authors.initials: D
authors.lastname: Spielvogel
authors.forename: Randall B
authors.initials: RB
authors.lastname: Griepp
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001018:Aortic Diseases / Q000601:surgery*; D001021:Aortic Valve / Q000601:surgery*; D001705:Bioprosthesis; D005260:Female; D006350:Heart Valve Prosthesis; D019918:Heart Valve Prosthesis Implantation / Q000379:methods*; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D012307:Risk Factors; D012737:Sex Factors; D016019:Survival Analysis; D016896:Treatment Outcome