Copper-catalyzed asymmetric reduction of 3,3-diarylacrylonitriles.
CuH-catalyzed enantioselective conjugate reduction of 3,3-diaryl-substituted acrylonitriles is described. A range of 3-aryl-3-pyridylacrylonitriles were reduced with high levels of enantioselectivity under optimal conditions employing a copper/Josiphos complex in the presence of polymethylhydrosiloxane (PMHS).
Lee
Daehyung
D
Department of Chemistry and Institute of Basic Science, Sungkyunkwan University, Suwon 440-746, Korea.
Yang
Youngmin
Y
Yun
Jaesook
J
D000181:Acrylonitrile / Q000031:analogs & derivatives* / Q000737:chemistry*; D002384:Catalysis; D002851:Chromatography, High Pressure Liquid; D003300:Copper / Q000737:chemistry*; D007202:Indicators and Reagents; D008024:Ligands; D010084:Oxidation-Reduction; D012833:Siloxanes / Q000737:chemistry; D013237:Stereoisomerism; D013696:Temperature
D007202:Indicators and Reagents; D008024:Ligands; D012833:Siloxanes; C402373:poly(methylhydrosiloxane); D003300:Copper; D000181:Acrylonitrile