Shelf life of predosed plates containing mefloquine, artemisinin, dihydroartemisinin, and artesunate as used for in vitro Plasmodium falciparum susceptibility assessment.
The shelf lives of preserved antimalarial agent-predosed plates according to the type of wrapping and the temperature of storage were studied by measuring the 50% inhibitory concentrations of drug for Plasmodium falciparum 3D7. The shelf life of mefloquine was 8 weeks at 25 degrees C; and those of artesunate, artemisinin, and dihydroartemisinin were a minimum of 24, 12, and 8 weeks, respectively, at 4 degrees C.
Houzé
Sandrine
S
Laboratoire de Parasitologie, Centre National de Référence du Paludisme, Assistance Publique-Hôpitaux de Paris, Hôpital Bichat-Claude Bernard, and Université Paris Descartes, EA 209, Paris, France. sandrine.houze@bch.aphp.fr
Munier
Aline
A
Paoletti
Xavier
X
Kaddouri
Halima
H
Ringwald
Pascal
P
Le Bras
Jacques
J
D000962:Antimalarials / Q000494:pharmacology*; D003470:Culture Media / Q000737:chemistry*; D004355:Drug Stability; D004356:Drug Storage; D021261:Parasitic Sensitivity Tests / Q000379:methods*
D000962:Antimalarials; D003470:Culture Media