[Expression of Survivin and its significance in tongue squamous cell carcinoma].
OBJECTIVE
To investigate the expression of Survivin,one of inhibitors of apoptosis proteins(IAPs) in tongue squamous cell carcinoma(TSCC), and discuss its clinical significance.


METHODS
Immunohistochemical staining was employed to detect the expression of Survivin in 10 normal lingual mucosal membranes, 13 highly differentiated SCCs,20 medium-differentiated SCCs and 12 low-differentiated SCCs. Data was analyzed with SPSS13 software package for nonparametric Kruskal-Wallis test and Mann-Whitney U test.


RESULTS
The positive staining rate of Survivin in TSCC was 68.9%, and significantly higher than that in normal control group (P<0.01). Overexpression of Survivin was related to the pathological grade, TNM stage (P<0.05) and closely to lymph node metastasis of TSCC (P<0.01).


CONCLUSIONS
The positive staining of Survivin increased in different grades of TSCC, and Survivin is relative to carcinogenesis, progression and prognosis of TSCC. It may be a new clinical therapeutic target for TSCC.
Wang
Zhi-ming
ZM
Department of Stomatology, Shengjing Hospital, China Medical University, Shenyang 110004, Liaoning Province, China. w_eve@sina.com
Liu
Fang
F
Guan
Xin-ming
XM
Zhang
Li-Ping
LP
D002294:Carcinoma, Squamous Cell / Q000378:metabolism*; D018450:Disease Progression; D006801:Humans; D007150:Immunohistochemistry; D051034:Inhibitor of Apoptosis Proteins / Q000378:metabolism*; D008207:Lymphatic Metastasis; D009367:Neoplasm Staging; D011379:Prognosis; D000077022:Survivin; D014062:Tongue Neoplasms / Q000378:metabolism*
C107489:BIRC5 protein, human; D051034:Inhibitor of Apoptosis Proteins; D000077022:Survivin