title: Glucose-6-phosphate dehydrogenase polymorphism and lymphoma risk.
abstract: OBJECTIVE
  Evidence linking the glucose-6-phosphate dehydrogenase (G6PD) polymorphism and risk of non-Hodgkin's lymphoma is conflicting. Risk of non-Hodgkin's lymphoma was increased in subjects expressing the G6PD deficient phenotype, whereas subjects under medication with statins, a lipid-lowering class of drugs partially mimicking G6PD deficiency, seemed to enjoy a protective effect.
  
  
  METHODS
  We conducted a case-control study on lymphoma risk associated with the self-reported G6PD deficient phenotype in 122 lymphoma male cases and 116 male controls in Sardinia, Italy. The association with the GdMed+ genotype, the most frequent variant expressing a deficient enzyme activity, was also tested in 49 male lymphoma cases and 31 controls. The WHO classification was used to identify lymphoma subentities.
  
  
  RESULTS
  Neither self-reported G6PD deficient phenotype nor the GdMed+ genotype showed an association with lymphoma risk or its subentities.
  
  
  CONCLUSIONS
  Our results do not confirm an association either positive or negative between the G6PD polymorphism and lymphoma risk.
authors.affiliation: Department of Public Health, Occupational Health Section, University of Cagliari, Cagliari, Italy. coccop@pacs.unica.it
authors.forename: Pierluigi
authors.initials: P
authors.lastname: Cocco
authors.forename: Maria G
authors.initials: MG
authors.lastname: Ennas
authors.forename: Maria A
authors.initials: MA
authors.lastname: Melis
authors.forename: Carla
authors.initials: C
authors.lastname: Sollaino
authors.forename: Stefania
authors.initials: S
authors.lastname: Collu
authors.forename: Domenica
authors.initials: D
authors.lastname: Fadda
authors.forename: Attilio
authors.initials: A
authors.lastname: Gabbas
authors.forename: Giovannino
authors.initials: G
authors.lastname: Massarelli
authors.forename: Marco
authors.initials: M
authors.lastname: Rais
authors.forename: Pierfelice
authors.initials: P
authors.lastname: Todde
authors.forename: Emanuele
authors.initials: E
authors.lastname: Angelucci
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D005954:Glucosephosphate Dehydrogenase / Q000235:genetics*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology; D008228:Lymphoma, Non-Hodgkin / Q000209:etiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D005954:Glucosephosphate Dehydrogenase