title: Bartonella-related pseudomembranous angiomatous papillomatosis of the oral cavity associated with allogeneic bone marrow transplantation and oral graft-versus-host disease.
abstract: Patients undergoing allogeneic stem cell transplantation are at high risk for infection with a variety of pathogens during different phases of the procedure. Human infections due to Bartonella spp. are viewed as emerging diseases typical in, although not exclusive to, immunosuppressed patients, in particular those with AIDS, organ transplants and haematological malignancies. We describe four patients, three children and one adult, who developed vegetating papillomatous lesions exclusively on the oral mucosae. They shared a history of haematological malignancy and allogeneic bone marrow/stem cell transplantation, and later developed chronic graft-versus-host disease, also involving the oral mucosae. Histopathologically, the vegetating lesions were characterized by a diffuse neoangiogenesis, granulation-like tissue, and a mixed cell infiltrate predominantly composed of neutrophils. Gram-negative bacteria were found in the endothelial cells of the vessels in the deeper portion of the corium by electron microscopy. In three cases, DNA of B. henselae was detected by polymerase chain reaction (PCR), and confirmed by sequencing of the PCR products. All the lesions healed after systemic antibiotic therapy, although some recurred after months, and regressed again after systemic antibiotic treatment associated with conservative surgical excision.
authors.affiliation: Department of Dermatology, Istituto di Ematologia, University of Pavia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy. cvassallo@yahoo.com
authors.forename: C
authors.initials: C
authors.lastname: Vassallo
authors.forename: M
authors.initials: M
authors.lastname: Ardigò
authors.forename: V
authors.initials: V
authors.lastname: Brazzelli
authors.forename: M
authors.initials: M
authors.lastname: Zecca
authors.forename: F
authors.initials: F
authors.lastname: Locatelli
authors.forename: P E
authors.initials: PE
authors.lastname: Alessandrino
authors.forename: M
authors.initials: M
authors.lastname: Lazzarino
authors.forename: S
authors.initials: S
authors.lastname: Corona
authors.forename: P
authors.initials: P
authors.lastname: Lanzerini
authors.forename: M
authors.initials: M
authors.lastname: Benazzo
authors.forename: M
authors.initials: M
authors.lastname: Fabbi
authors.forename: G
authors.initials: G
authors.lastname: Borroni
mesh_terms: D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001473:Bartonella; D001474:Bartonella Infections / Q000150:complications* / Q000188:drug therapy; D016026:Bone Marrow Transplantation / Q000009:adverse effects / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006086:Graft vs Host Disease / Q000209:etiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000382:microbiology; D009894:Opportunistic Infections / Q000150:complications* / Q000188:drug therapy; D010212:Papilloma / Q000188:drug therapy / Q000382:microbiology*; D014060:Tongue Diseases / Q000188:drug therapy / Q000209:etiology* / Q000382:microbiology*; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents