title: [Hepatocellular carcinoma occurring after 11 year-long sustained viral response to interferon therapy for chronic hepatitis C].
abstract: The patient was a 61-year-old man with chronic hepatitis C who achieved a sustained virological response to interferon therapy in 1993. As a result, the status of his liver improved pathologically from F2A2 to F1A1. Eleven years later, however, a tumor measuring 15 mm in diameter in segment 6 of the liver was indicated by CT. A well-differentiated hepatocellular carcinoma was detected by a fine needle biopsy. The lesion was treated by transcatheter arterial chemoembolization combined with radiofrequency ablation. Even if patients with chronic hepatitis C have achieved a sustained virological response to interferon therapy, patients with risk factors for the development of hepatocellular carcinoma, such as being a male of advanced age and with progressive fibrosis of the liver, should receive careful long-term follow-up.
authors.affiliation: Division of Hepatology, Department of Internal Medicine, Kawasaki Medical School.
authors.forename: Fumi
authors.initials: F
authors.lastname: Suganami
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Tomiyama
authors.forename: Kenji
authors.initials: K
authors.lastname: Ohmoto
authors.forename: Tomoya
authors.initials: T
authors.lastname: Kawase
authors.forename: Naoko
authors.initials: N
authors.lastname: Yoshioka
authors.forename: Norikuni
authors.initials: N
authors.lastname: Shibata
authors.forename: Koji
authors.initials: K
authors.lastname: Yoshida
authors.forename: Makoto
authors.initials: M
authors.lastname: Kuboki
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Yamamoto
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use*; D006528:Carcinoma, Hepatocellular / Q000209:etiology*; D019698:Hepatitis C, Chronic / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D007372:Interferons / Q000627:therapeutic use*; D008113:Liver Neoplasms / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D013997:Time Factors
chemical_list: D000998:Antiviral Agents; D007372:Interferons