Chorionic villus sampling and risk for hypertensive disorders of pregnancy.
OBJECTIVE
This study was undertaken to evaluate the relationship between chorionic villus sampling at 10-13 weeks' gestational age and hypertensive disorders of pregnancy.


METHODS
The prevalence of hypertensive disorders of pregnancy in women with singleton gestations, undergoing transcervical or transabdominal chorionic villus sampling between 10 weeks 0 days' and 13 weeks 6 days' gestational age was compared with that of control women with singleton gestations having first-trimester screening with nuchal translucency and biochemistry between 11 weeks 0 days' and 13 weeks 6 days' gestational age. Patients having invasive prenatal diagnosis (chorionic villus sampling or amniocentesis) were excluded from the control group. All patients delivered at Cedars-Sinai Medical Center.


RESULTS
There were 1540 women who had chorionic villus sampling and 840 controls. Hypertensive disorders of pregnancy were diagnosed in 76 (4.9%) patients in the chorionic villus sampling group and in 37 (4.4%) of the controls (chi2 = 0.34, P = .31).


CONCLUSIONS
Chorionic villus sampling at 10 to 13 weeks' gestational age does not appear to increase the overall risk for hypertensive disorders of pregnancy. However, there appears to be an association between chorionic villus sampling and severe hypertensive disorders including severe preeclampsia, eclampsia, and hemolysis, elevated liver enzymes, and low platelet count syndrome.
Adusumalli
Jasvant
J
Division of Maternal-Fetal Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA. Jasvant.adusumalli@cshs.org
Han
Christina S
CS
Beckham
Stephen
S
Bartholomew
Marguerite L
ML
Williams
John
J
D000328:Adult; D002140:California / Q000453:epidemiology; D016022:Case-Control Studies; D015193:Chorionic Villi Sampling; D005260:Female; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000453:epidemiology; D008875:Middle Aged; D011247:Pregnancy; D012189:Retrospective Studies