title: Longitudinal genetic analysis of internalizing and externalizing problem behavior in adopted biologically related and unrelated sibling pairs.
abstract: To obtain a better understanding of how genetic and environmental processes are involved in the stability and change in problem behavior from early adolescence into adulthood, studies with genetically informative samples are important. The present study used parent-reported data on internalizing and externalizing problem behavior of adoptees at mean ages 12.4, 15.5 and 26.3. In this adoption study adopted biologically related sibling pairs shared on average 50% of their genes and were brought up in the same family environment, whereas adopted biologically unrelated sibling pairs only shared their family environment. The resemblance between these adopted biologically related (N = 106) and unrelated sibling pairs (N=230) was compared and examined over time. We aimed to investigate (1) to what extent are internalizing and externalizing problem behavior stable from early adolescence into adulthood, and (2) whether the same or different genetic and environmental factors affect these problem behaviors at the 3 assessments. Our results show that both internalizing (rs ranging from .34 to .58) and externalizing behavior (rs ranging from .47 to .69) were rather stable over time. For internalizing and externalizing problem behavior it was found that both genetic and shared environmental influences could be modeled by an underlying common factor, which explained variance in problem behavior from early adolescence into adulthood and accounted for stability over time. The nonshared environmental influences were best modeled by a Cholesky decomposition for internalizing behavior, whereas a time-specific influence of the nonshared environment was included in the final model of externalizing behavior.
authors.affiliation: Department of Child and Adolescent Psychiatry, Erasmus Medical Center, Rotterdam/Sophia Children's Hospital, CB Rotterdam, The Netherlands. a.c.huizink@erasmusmc.nl
authors.forename: Anja C
authors.initials: AC
authors.lastname: Huizink
authors.forename: Mijke P
authors.initials: MP
authors.lastname: van den Berg
authors.forename: Jan
authors.initials: J
authors.lastname: van der Ende
authors.forename: Frank C
authors.initials: FC
authors.lastname: Verhulst
mesh_terms: D000293:Adolescent; D000300:Adoption; D000328:Adult; D001519:Behavior; D002648:Child; D005195:Family Relations; D005260:Female; D005824:Genetics, Behavioral; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D001523:Mental Disorders / Q000235:genetics*; D008957:Models, Genetic; D009426:Netherlands; D012307:Risk Factors; D035781:Siblings; D013997:Time Factors