Diabetic nephropathy and proximal tubule ROS: challenging our glomerulocentricity.
Diabetic nephropathy is currently viewed as a predominantly glomerular process with glomerular injury driving secondary tubular loss. Brezniceanu and colleagues apply transgenic methods to support a prominent role for reactive oxygen species as mediators and for the proximal tubule as a major site of early disease activity in diabetes. Results support evidence for early tubular apoptosis and atrophy in human diabetic nephropathy.
Bagby
S P
SP
Department of Medicine, Oregon Health & Science University, Portland, Oregon 97239-2940, USA. bagbys@ohsu.edu
D000818:Animals; D017209:Apoptosis; D001284:Atrophy; D003928:Diabetic Nephropathies / Q000209:etiology*; D007678:Kidney Glomerulus / Q000378:metabolism / Q000473:pathology*; D007687:Kidney Tubules, Proximal / Q000378:metabolism / Q000473:pathology*; D051379:Mice; D008822:Mice, Transgenic; D017382:Reactive Oxygen Species / Q000378:metabolism*
D017382:Reactive Oxygen Species