A novel HLA-B*35 (B*3570) allele of a Caucasian family differing with one amino acid mismatch from HLA-B*3503 allele in exon 4.
A novel human leucocyte antigen (HLA)-B35 (HLA-B*3570) allele has been identified in a Caucasian family from Middle Europe using single allele-specific sequencing strategy. This allele is identical to the HLA-B*3503 allele except for one point mutation in exon 4 at codon 188 (CAC-->CGC), resulting in an amino acid change from histidine to arginine.
Schlaf
G
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Institute of Medical Immunology, Interbranch HLA-Laboratory, Martin Luther University Halle-Wittenberg, Magdeburger Strasse 16, D-06097 Halle, Germany.
Erhuma
M E
ME
Seliger
B
B
Foell
J
J
Altermann
W W
WW
D000483:Alleles; D019943:Amino Acid Substitution; D001120:Arginine / Q000378:metabolism; D001483:Base Sequence; D002648:Child; D003062:Codon; D005091:Exons; D005190:Family; D005260:Female; D015235:HLA-B Antigens / Q000737:chemistry / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D008969:Molecular Sequence Data; D009447:Neuroblastoma / Q000473:pathology; D017354:Point Mutation; D017422:Sequence Analysis, DNA; D044465:White People / Q000235:genetics*
D003062:Codon; D015235:HLA-B Antigens; D001120:Arginine