title: The large vestibular aqueduct: a new definition based on audiologic and computed tomography correlation.
abstract: OBJECTIVE
  The study goal was to determine the prevalence and clinical significance of a large vestibular aqueduct (LVA) in children with sensorineural hearing loss (SNHL).
  
  
  METHODS
  We conducted a retrospective review of a pediatric SNHL database. One hundred seven children with SNHL were selected and their radiographic and audiometric studies were evaluated. Radiographic comparisons were made to a group of children without SNHL.
  
  
  RESULTS
  A vestibular aqueduct (VA) larger than the 95th percentile of controls was present in 32% of children with SNHL. Progressive SNHL was more likely to occur in ears with an LVA and the rate of progressive hearing loss was greater than in ears without an LVA. The risk of progressive SNHL increased with increasing VA size as determined by logistic regression analysis.
  
  
  CONCLUSIONS
  An LVA is defined as one that is >or=2 mm at the operculum and/or >or=1 mm at the midpoint in children with nonsyndromic SNHL. An LVA appears to be more common than previously reported in children with SNHL. A linear relationship is observed between VA width and progressive SNHL.
  
  
  CONCLUSIONS
  The finding of an LVA in children with SNHL provides diagnostic as well as prognostic information.
authors.affiliation: Ear and Hearing Center, Cincinnati Children's Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
authors.forename: Mark
authors.initials: M
authors.lastname: Boston
authors.forename: Mark
authors.initials: M
authors.lastname: Halsted
authors.forename: Jareen
authors.initials: J
authors.lastname: Meinzen-Derr
authors.forename: Judy
authors.initials: J
authors.lastname: Bean
authors.forename: Shyan
authors.initials: S
authors.lastname: Vijayasekaran
authors.forename: Ellis
authors.initials: E
authors.lastname: Arjmand
authors.forename: Daniel
authors.initials: D
authors.lastname: Choo
authors.forename: Corning
authors.initials: C
authors.lastname: Benton
authors.forename: John
authors.initials: J
authors.lastname: Greinwald
mesh_terms: D001301:Audiometry, Pure-Tone; D002648:Child; D004108:Dilatation, Pathologic / Q000000981:diagnostic imaging; D018450:Disease Progression; D005260:Female; D006319:Hearing Loss, Sensorineural / Q000000981:diagnostic imaging* / Q000209:etiology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D012016:Reference Values; D012307:Risk Factors; D014057:Tomography, X-Ray Computed; D014723:Vestibular Aqueduct / Q000002:abnormalities* / Q000000981:diagnostic imaging*