title: Laparoscopic surgery is safe for large adrenal lesions.
abstract: BACKGROUND
  Laparoscopic adrenalectomy has surpassed open adrenalectomy as the gold standard for excision of benign adrenal lesions. The size threshold for offering laparoscopic adrenalectomy is controversial as the prevalence of adrenocortical carcinoma increases with increasing tumour size. The aim of this paper was to assess the safety of laparoscopic adrenalectomy for large adrenal tumours (tumours > or = 60 mm).
  
  
  METHODS
  A retrospective cohort study of patients who underwent adrenalectomy in a single unit during the period 1995-2005 was undertaken.
  
  
  RESULTS
  One hundred and seventy patients with 173 tumours were included in this study. Of these, 29 were > or = 60 mm in size, and 16 of these patients underwent laparoscopic adrenalectomy. There were 8 adrenocortical carcinomas in the group with tumours > or = 60 mm in size. Five of these patients underwent an open adrenalectomy, while 2 and 1 patients had laparoscopic and laparoscopic converted to open adrenalectomy respectively. Four of the patients undergoing open adrenalectomy died of their disease while 1 is alive with recurrence 3 years later. The 3 patients who underwent either laparoscopic or laparoscopic converted to open adrenalectomy are alive without evidence of disease after 18 months follow up.
  
  
  CONCLUSIONS
  Our data show that patients with tumours > or = 60 mm with no preoperative or intraoperative evidence of malignancy can undergo laparoscopic adrenalectomy without evidence of recurrence on short term follow up. These findings are concordant with the growing body of literature supporting laparoscopic adrenalectomy for potentially malignant tumours > or = 60 mm in size without preoperative or intraoperative features of malignancy.
authors.affiliation: University of Sydney Endocrine Surgical Unit, Royal North Shore Hospital, Sydney, New South Wales, Australia.
authors.forename: P S H
authors.initials: PS
authors.lastname: Soon
authors.forename: M W
authors.initials: MW
authors.lastname: Yeh
authors.forename: L W
authors.initials: LW
authors.lastname: Delbridge
authors.forename: C P
authors.initials: CP
authors.lastname: Bambach
authors.forename: M S
authors.initials: MS
authors.lastname: Sywak
authors.forename: B G
authors.initials: BG
authors.lastname: Robinson
authors.forename: S B
authors.initials: SB
authors.lastname: Sidhu
mesh_terms: D000306:Adrenal Cortex Neoplasms / Q000601:surgery; D000310:Adrenal Gland Neoplasms / Q000601:surgery*; D000315:Adrenalectomy; D018268:Adrenocortical Carcinoma / Q000601:surgery; D005260:Female; D006801:Humans; D010535:Laparoscopy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D013997:Time Factors