title: Mamu-B*08-positive macaques control simian immunodeficiency virus replication.
abstract: Certain major histocompatibility complex (MHC) class I alleles are associated with the control of human immunodeficiency virus and simian immunodeficiency virus (SIV) replication. We have designed sequence-specific primers for detection of the rhesus macaque MHC class I allele Mamu-B*08 by PCR and screened a cohort of SIV-infected macaques for this allele. Analysis of 196 SIV(mac)239-infected Indian rhesus macaques revealed that Mamu-B*08 was significantly overrepresented in elite controllers; 38% of elite controllers were Mamu-B*08 positive compared to 3% of progressors (P = 0.00001). Mamu-B*08 was also associated with a 7.34-fold decrease in chronic phase viremia (P = 0.002). Mamu-B*08-positive macaques may, therefore, provide a good model to understand the correlates of MHC class I allele-associated immune protection and viral containment in human elite controllers.
authors.affiliation: Wisconsin National Primate Research Center, University of Wisconsin-Madison, 555 Science Drive, Madison, WI 53711, USA.
authors.forename: John T
authors.initials: JT
authors.lastname: Loffredo
authors.forename: Jess
authors.initials: J
authors.lastname: Maxwell
authors.forename: Ying
authors.initials: Y
authors.lastname: Qi
authors.forename: Chrystal E
authors.initials: CE
authors.lastname: Glidden
authors.forename: Gretta J
authors.initials: GJ
authors.lastname: Borchardt
authors.forename: Taeko
authors.initials: T
authors.lastname: Soma
authors.forename: Alex T
authors.initials: AT
authors.lastname: Bean
authors.forename: Dominic R
authors.initials: DR
authors.lastname: Beal
authors.forename: Nancy A
authors.initials: NA
authors.lastname: Wilson
authors.forename: William M
authors.initials: WM
authors.lastname: Rehrauer
authors.forename: Jeffrey D
authors.initials: JD
authors.lastname: Lifson
authors.forename: Mary
authors.initials: M
authors.lastname: Carrington
authors.forename: David I
authors.initials: DI
authors.lastname: Watkins
mesh_terms: D000483:Alleles; D000818:Animals; D001483:Base Sequence; D005820:Genetic Testing; D015395:Histocompatibility Antigens Class I / Q000235:genetics* / Q000378:metabolism; D008253:Macaca mulatta; D008969:Molecular Sequence Data; D016097:Simian Acquired Immunodeficiency Syndrome / Q000235:genetics* / Q000276:immunology; D015302:Simian Immunodeficiency Virus / Q000502:physiology*; D014766:Viremia / Q000235:genetics / Q000276:immunology; D014779:Virus Replication
chemical_list: D015395:Histocompatibility Antigens Class I