title: Genital human papilloma virus infection in mentally-institutionalized virgins.
abstract: OBJECTIVE
  Human papilloma virus (HPV) can cause cervical cancer. Risk factors for HPV infection are primarily related to sexual behavior. We determined the prevalence of HPV infection and abnormal cervical cytology in institutionalized women with no previous sexual experience.
  
  
  METHODS
  The study subjects were 251 patients who sought screening for cervical cancer (45.9+/-9.4 years, mean+/-S.D., range, 14 to 66). They were institutionalized for psychosomatic disorders since childhood, and had no previous sexual experience. In addition to screening for cervical cancer, specimens for HPV testing were collected.
  
  
  RESULTS
  No women who were positive for HPV DNA was detected, though 251 women without sexual experiences were screened by the hybrid capture 2 test including 26 types of HPV-DNA.
  
  
  CONCLUSIONS
  Transmission through means other than sexual intercourse may not exist because we could not detect HPV DNA in 251 women with no previous sexual experience.
authors.affiliation: Department of Obstetrics and Gynecology, Nagasaki University Graduated School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki 852-8501, and Yasunaga Obstetrics and Gynecology Hospital, Isahaya, Japan. shimachan-ngs@umin.ac.jp
authors.forename: Takako
authors.initials: T
authors.lastname: Shimada
authors.forename: Masako
authors.initials: M
authors.lastname: Miyashita
authors.forename: Shoko
authors.initials: S
authors.lastname: Miura
authors.forename: Daisuke
authors.initials: D
authors.lastname: Nakayama
authors.forename: Kiyonori
authors.initials: K
authors.lastname: Miura
authors.forename: Masafumi
authors.initials: M
authors.lastname: Fukuda
authors.forename: Hideaki
authors.initials: H
authors.lastname: Masuzaki
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007326:Institutionalization; D008875:Middle Aged; D030361:Papillomavirus Infections / Q000453:epidemiology* / Q000473:pathology; D012725:Sexual Behavior; D002577:Uterine Cervical Diseases / Q000453:epidemiology / Q000473:pathology / Q000821:virology*; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology / Q000473:pathology / Q000821:virology*; D014626:Vaginal Smears