title: Lack of cardiotoxicity with liposomal doxorubicin in an elderly case of ovarian cancer.
abstract: Ovarian cancer is typically a disease of elderly women, usually occurring after menopause with a peak incidence in the eighth decade of life. Elderly patients are more likely to suffer the adverse effects of chemotherapy, which may influence successive lines of treatment. We describe the case of an elderly woman with platinum-sensitive ovarian cancer treated with several lines of chemotherapy who developed acute cardiogenic pulmonary edema with her first line of therapy, which included paclitaxel, and her fourth line containing gemcitabine. However, a complete regimen of pegylated liposomal doxorubicin in association with oxaliplatin was well tolerated. Other authors have reported absence of cardiotoxicity with liposomal doxorubicin in their study populations, but no mention was made of patients with a known prior susceptibility to transient heart failure when treated with other chemotherapeutic agents. Our case provides evidence that even in these more difficult-to-treat cases, where cumulative cardiotoxicity may be relatively unpredictable, liposomal doxorubicin does not affect cardiac function.
authors.affiliation: Medical Oncology Department, Istituto Oncologico Veneto, Padua, Italy. mariaorn@libero.it
authors.forename: Maria Ornella
authors.initials: MO
authors.lastname: Nicoletto
authors.forename: Martin
authors.initials: M
authors.lastname: Donach
authors.forename: Lucia
authors.initials: L
authors.lastname: Borgato
authors.forename: Cristina
authors.initials: C
authors.lastname: Falci
authors.forename: Lucia
authors.initials: L
authors.lastname: Zanin
authors.forename: Giovanni
authors.initials: G
authors.lastname: De Masi
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use / Q000633:toxicity; D002302:Cardiac Output / Q000187:drug effects*; D004317:Doxorubicin / Q000031:analogs & derivatives* / Q000627:therapeutic use / Q000633:toxicity; D064420:Drug-Related Side Effects and Adverse Reactions; D005260:Female; D006801:Humans; D009944:Organoplatinum Compounds / Q000627:therapeutic use; D010051:Ovarian Neoplasms / Q000150:complications / Q000188:drug therapy*; D000077150:Oxaliplatin; D011092:Polyethylene Glycols / Q000627:therapeutic use* / Q000633:toxicity; D011654:Pulmonary Edema / Q000139:chemically induced
chemical_list: D009944:Organoplatinum Compounds; C506643:liposomal doxorubicin; D000077150:Oxaliplatin; D011092:Polyethylene Glycols; D004317:Doxorubicin