Novel ebselen-porphyrin conjugates: synthesis and nucleic acid interaction study.
Novel porphyrins bearing ebselen (2-phenyl-1,2-benzisoselenazol-3[2H]-one) moiety were synthesized and characterized. Their interactions with herring sperm DNA were studied by means of UV-visible, fluorescence, circular dichroism spectroscopy, and gel electrophoresis.
Xue
Zhi
Z
Department of Chemistry, Wuhan University, Wuhan 430072, PR China.
Hou
An-Xin
AX
Kwong
Daniel Wei-Jing
DW
Wong
Wai-Kwok
WK
D001393:Azoles / Q000737:chemistry*; D002942:Circular Dichroism; D054833:Isoindoles; D009696:Nucleic Acids / Q000737:chemistry*; D016566:Organoselenium Compounds / Q000737:chemistry*; D011166:Porphyrins / Q000737:chemistry*; D013050:Spectrometry, Fluorescence; D013056:Spectrophotometry, Ultraviolet
D001393:Azoles; D054833:Isoindoles; D009696:Nucleic Acids; D016566:Organoselenium Compounds; D011166:Porphyrins; C042986:ebselen