title: Sugar sensing based on induced pH changes.
abstract: A sensory assembly consisting of a pH sensitive NIR dye and an arylboronic acid shows ratiometric absorption changes with increased fluorescence intensity upon addition of sugar in aqueous media; this demonstrates a new signal transduction mechanism for the detection of sugar based on pH changes induced in the microenvironment of the sensory assembly.
authors.affiliation: Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA.
authors.forename: Youngmi
authors.initials: Y
authors.lastname: Kim
authors.forename: Scott A
authors.initials: SA
authors.lastname: Hilderbrand
authors.forename: Ralph
authors.initials: R
authors.lastname: Weissleder
authors.forename: Ching-Hsuan
authors.initials: CH
authors.lastname: Tung
mesh_terms: D000042:Absorption; D015374:Biosensing Techniques; D001897:Boronic Acids / Q000737:chemistry*; D002241:Carbohydrates / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000737:chemistry*; D006841:Hydrocarbons, Aromatic / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D007259:Infrared Rays; D012995:Solubility; D013050:Spectrometry, Fluorescence; D014867:Water / Q000737:chemistry
chemical_list: D001897:Boronic Acids; D002241:Carbohydrates; D005456:Fluorescent Dyes; D006841:Hydrocarbons, Aromatic; D014867:Water