Long-term survival is possible after stenting for malignant ureteric obstruction in colorectal cancer.
BACKGROUND
Ureteric obstruction is a potentially terminal event in patients with irresectable or recurrent colorectal cancer. Urinary tract obstruction is easily relieved by either two stage antegrade stenting or one stage retrograde stenting. However, there is little in the literature about outcomes after this procedure and it is unclear which, if any, patients should be offered this intervention.


METHODS
This was a retrospective review of a prospectively collected database of patients diagnosed with colorectal cancer. This database comprised 1428 cases (operative and non-operative) diagnosed at a single institution. This was cross-checked with databases for patients undergoing nephrostomy and/or antegrade stenting and by clinical coding for those patients having retrograde stenting between January 1996 and October 2004.


RESULTS
Thirteen patients were identified (median age, 69 years: range, 35-85 years; 9 male). The aetiology of obstruction was recurrent tumour in 6 patients and irresectable tumour in the remaining 7 patients. Two patients were discussed at a urology multidisciplinary meeting before stenting and a further two were discussed with colorectal surgeons. One patient received a palliative cystectomy and ileal conduit for a vesicovaginal fistula followed by radiotherapy. Four patients received chemotherapy after stenting. Overall median survival was 210 days (range, 13-927 days).


CONCLUSIONS
Long-term survival is possible in selected patients with recurrent or irresectable colorectal cancer and malignant ureteric obstruction. This appears to be more likely in those patients in whom other treatments, particularly chemotherapy, are available.
Jones
Oliver M
OM
Department of Colorectal Surgery, Royal Bournemouth Hospital, Bournemouth, UK. oliverjones10@hotmail.com
John
Solomon K P
SK
Lawrance
Richard J
RJ
Fozard
J Basil J
JB
D000328:Adult; D000368:Aged; D015179:Colorectal Neoplasms / Q000150:complications* / Q000401:mortality; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality; D011446:Prospective Studies; D012189:Retrospective Studies; D015607:Stents; D016019:Survival Analysis; D014517:Ureteral Obstruction / Q000209:etiology / Q000401:mortality / Q000601:surgery*