Peripheral T-cell lymphoma with diffuse pulmonary infiltration and an increase in serum KL-6 level.
Peripheral T-cell lymphoma is a subtype of non-Hodgkin's lymphoma. A case of peripheral T-cell lymphoma showing diffuse pulmonary involvement together with a marked increase in the level of serum KL-6 is presented. CXR and CT revealed reticular and ground-glass opacities, which mimicked interstitial pneumonia. Immunopathological findings and an analysis of T-cell receptor gene rearrangements of the lung biopsy specimen led to a definite diagnosis of peripheral T-cell lymphoma. In addition, the extensive proliferation of type II pneumocytes, which stained strongly positive for anti-KL-6 antibody suggested that the pneumocytes were the source of serum KL-6.
Fujisawa
Tomoyuki
T
Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan.
Suda
Takafumi
T
Matsuura
Shun
S
Enomoto
Noriyuki
N
Takeshita
Kaori
K
Ohnishi
Kazunori
K
Chida
Kingo
K
D000951:Antigens, Neoplasm / Q000097:blood*; D003937:Diagnosis, Differential; D006801:Humans; D008168:Lung / Q000473:pathology; D017563:Lung Diseases, Interstitial / Q000175:diagnosis; D008175:Lung Neoplasms / Q000097:blood / Q000175:diagnosis / Q000473:pathology*; D016411:Lymphoma, T-Cell, Peripheral / Q000097:blood / Q000175:diagnosis / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D018396:Mucin-1; D009077:Mucins / Q000097:blood*; D009361:Neoplasm Invasiveness / Q000473:pathology; D011948:Receptors, Antigen, T-Cell / Q000235:genetics
D000951:Antigens, Neoplasm; C060192:MUC1 protein, human; D018396:Mucin-1; D009077:Mucins; D011948:Receptors, Antigen, T-Cell