Progesterone rise on the day of human chorionic gonadotropin administration impairs pregnancy outcome in day 3 single-embryo transfer, while has no effect on day 5 single blastocyst transfer.
Four hundred eighty-two patients undergoing single ET with GnRH-antagonist/recFSH protocol were analyzed. The incidence of premature luteinization (P above 1.5 ng/mL on the day of hCG administration) was 18.2%. Even modest rises of P in the follicular phase have detrimental effect on the implantation potential of a good-quality cleavage stage embryo. On the contrary, premature luteinization in the blastocyst subgroup had no effect on the pregnancy outcome.
Papanikolaou
Evangelos G
EG
Centre for Reproductive Medicine, University Hospital, Vrije Univestiteit Brussel, Free University of Brussels, Brussels, Belgium. Evangelos.Papanikolaou@vub.ac.be
Kolibianakis
Efstratios M
EM
Pozzobon
Cristina
C
Tank
Parikshit
P
Tournaye
Herman
H
Bourgain
Claire
C
Van Steirteghem
Andre
A
Devroey
Paul
P
D000328:Adult; D006063:Chorionic Gonadotropin / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D010064:Embryo Implantation; D004624:Embryo Transfer; D005260:Female; D005300:Fertility Agents, Female / Q000008:administration & dosage*; D005640:Follicle Stimulating Hormone / Q000008:administration & dosage; D007987:Gonadotropin-Releasing Hormone / Q000037:antagonists & inhibitors; D006727:Hormone Antagonists / Q000008:administration & dosage; D006801:Humans; D008183:Luteal Phase / Q000097:blood / Q000187:drug effects*; D010062:Ovulation Induction / Q000009:adverse effects*; D011247:Pregnancy; D011256:Pregnancy Outcome; D011374:Progesterone / Q000097:blood*; D011446:Prospective Studies; D011994:Recombinant Proteins / Q000008:administration & dosage; D013997:Time Factors; D015854:Up-Regulation
D006063:Chorionic Gonadotropin; D005300:Fertility Agents, Female; D006727:Hormone Antagonists; D011994:Recombinant Proteins; D007987:Gonadotropin-Releasing Hormone; D011374:Progesterone; D005640:Follicle Stimulating Hormone