title: Acute colonic pseudo-obstruction in postchemotherapy complication of brain tumor treated with neostigmine.
abstract: Acute colonic pseudo-obstruction is characterized by dilatation of the large bowel without mechanical obstruction. Although the first step of the treatment is conservative management, mechanical decompression should be performed when symptoms persist. Recently, the efficacy of pharmacologic treatment has been reported in adults, but no such data have yet been reported in children for treatment of acute colonic pseudo-obstruction resulting from chemotherapy. We report a 9-year-old boy with acute colonic pseudo-obstruction caused by chemotherapy for brain tumor who did not respond to initial supportive therapy, but who was successfully treated with neostigmine.
authors.affiliation: Department of Pediatrics, Division of Pediatric Hematology/Oncology, St Mary's Hospital, The Catholic University of Korea, Seoul, Korea.
authors.forename: Tai-Sung
authors.initials: TS
authors.lastname: Kim
authors.forename: Jae-Wook
authors.initials: JW
authors.lastname: Lee
authors.forename: Min-Ji
authors.initials: MJ
authors.lastname: Kim
authors.forename: Young-Shil
authors.initials: YS
authors.lastname: Park
authors.forename: Dae-Hyoung
authors.initials: DH
authors.lastname: Lee
authors.forename: Nak-Gyun
authors.initials: NG
authors.lastname: Chung
authors.forename: Bin
authors.initials: B
authors.lastname: Cho
authors.forename: Soonju
authors.initials: S
authors.lastname: Lee
authors.forename: Hack-Ki
authors.initials: HK
authors.lastname: Kim
mesh_terms: D000208:Acute Disease; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000188:drug therapy*; D002432:Cecum / Q000473:pathology; D002648:Child; D003106:Colon / Q000473:pathology; D003112:Colonic Pseudo-Obstruction / Q000139:chemically induced* / Q000188:drug therapy*; D006801:Humans; D008297:Male; D009388:Neostigmine / Q000627:therapeutic use*
chemical_list: D009388:Neostigmine