title: [Effects of baicalin and other Chinese herbal monomer on androgen receptor mRNA expression in SZ95 sebocytes].
abstract: OBJECTIVE
  To determine the effects of Chinese herbal monomers such as baicalin, berberine, and matrine on the androgen receptor (AR) mRNA expression in SZ95 sebocytes in vitro and to explore the possible mechanism of using traditional Chinese medicines to treat acne.
  
  
  METHODS
  SZ95 sebocytes were cultured and then treated with berberine, baicalin, matrine, and 13-cis-retinoic acid for 24 hours. Reverse transcription polymerase chain reaction was applied to detect the changes of AR.
  
  
  RESULTS
  AR mRNA was downregulated by 13-cis-retinoic acid of 1 x 10(-5) mol/L and 1 x 10(-6) mol/L, and by baicalin of 1 x 10(-4) mol/L (P < 0.05).
  
  
  CONCLUSIONS
  13-cis-retinoic acid and baicalin may exert antiandrogenitic action by inhibiting AR mRNA expression in human sebocytes.
authors.affiliation: Department of Dermatology, Xuzhou NO 1 People' Hospital, Xuzhou, Jiangsu 221002, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Ju
authors.forename: Xing-Ping
authors.initials: XP
authors.lastname: Yin
authors.forename: Ji-Hai
authors.initials: JH
authors.lastname: Shi
authors.forename: Xiao-Jing
authors.initials: XJ
authors.lastname: Kang
authors.forename: Yan
authors.initials: Y
authors.lastname: Xin
authors.forename: Long-Qing
authors.initials: LQ
authors.lastname: Xia
mesh_terms: D000726:Androgen Antagonists / Q000494:pharmacology*; D002460:Cell Line; D015536:Down-Regulation; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005419:Flavonoids / Q000494:pharmacology*; D006801:Humans; D012333:RNA, Messenger / Q000096:biosynthesis*; D011944:Receptors, Androgen / Q000096:biosynthesis* / Q000235:genetics; D012867:Skin / Q000166:cytology
chemical_list: D000726:Androgen Antagonists; D004365:Drugs, Chinese Herbal; D005419:Flavonoids; D012333:RNA, Messenger; D011944:Receptors, Androgen; C038044:baicalin