MGEA5-14 polymorphism and type 2 diabetes in Mexico City.
A family-based study has recently reported that a variant located in intron 10 of the gene MGEA5 increases susceptibility to Type 2 Diabetes (T2D). We evaluated the distribution of this SNP in a sample of T2D patients (N = 271) and controls (N = 244) from Mexico City. The frequency of the T allele was higher in the cases (2.6%) than in the controls (1.8%). After adjusting for age, sex, BMI, education, and individual ancestry the odds ratio was 1.60 but the 95% confidence interval was wide and overlapped 1 (0.52-4.86, P-value : 0.404). In order to characterize the distribution of the MGEA5-14 polymorphism in the relevant parental populations, we genotyped this variant in European (and European Americans), West African, and Native American samples. The T-allele was present at a frequency of 2.3% in Spain, 4.2% in European Americans, and 13% in Western Africans, but was absent in two Native American samples from Mexico and Peru. Given the low frequency of the T-allele, further studies using large sample sizes will be required to confirm the role of this variant in T2D.
Cameron
E A
EA
Department of Anthropology, University of Toronto at Mississauga, Ontario, Canada.
Martinez-Marignac
V L
VL
Chan
A
A
Valladares
A
A
Simmonds
L V
LV
Wacher
N
N
Kumate
J
J
McKeigue
P
P
Shriver
M D
MD
Kittles
R
R
Cruz
M
M
Parra
E J
EJ
D000951:Antigens, Neoplasm / Q000235:genetics*; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000208:ethnology / Q000235:genetics*; D005260:Female; D051548:Histone Acetyltransferases / Q000235:genetics*; D006801:Humans; D006821:Hyaluronoglucosaminidase; D007198:Indians, North American / Q000235:genetics*; D007199:Indians, South American; D008297:Male; D008800:Mexico; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D013030:Spain; D001619:beta-N-Acetylhexosaminidases / Q000235:genetics*
D000951:Antigens, Neoplasm; D051548:Histone Acetyltransferases; C115866:OGA protein, human; D006821:Hyaluronoglucosaminidase; D001619:beta-N-Acetylhexosaminidases