Clinical significance of silent cerebral infarctions in patients with Alzheimer disease.
BACKGROUND
Although recent advances in the epidemiology of Alzheimer disease (AD) suggest a strong association between vascular factors predisposing to cerebrovascular disease and AD, the results of many studies on the relation between cerebrovascular disease and AD have been yet controversial. Therefore, we conducted this study to clarify the relation between concomitant silent cerebral infarctions and the cognitive decline of AD patients.


METHODS
One hundred and fifty subjects participated in this study: 51 patients had AD, 44 patients had AD with silent cerebral infarction (ADI), and there were 45 control subjects. These subjects received the global cognitive function testing and they were all evaluated with detailed neuropsychologic tests including attention, memory, language, and also the visuospatial and frontal function.


RESULTS
Compared with the control group, the patients with AD and ADI demonstrated significantly impairments in all cognitive domains. The ADI group showed more marked impairment than did the AD group on the domains including the language function, the delayed recall test, and semantic fluency.


CONCLUSIONS
ADI showed more severe cognitive decline than AD, indicating that cerebrovascular disease contributes to the severity of cognitive decline. These results suggest that prevention of cerebrovascular disease can play an important role in preventing the rapid cognitive decline of AD.
Song
In-Uk
IU
Department of Neurology, College of Medicine, The Catholic University of Korea.
Kim
Joong-Seok
JS
Kim
Yeong-In
YI
Eah
Kyung-Yoon
KY
Lee
Kwang-Soo
KS
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D000704:Analysis of Variance; D016022:Case-Control Studies; D002544:Cerebral Infarction / Q000150:complications / Q000473:pathology*; D003072:Cognition Disorders / Q000150:complications* / Q000473:pathology; D005625:Frontal Lobe / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D016555:Matched-Pair Analysis; D008875:Middle Aged; D009483:Neuropsychological Tests; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric; D013702:Temporal Lobe / Q000473:pathology