The impact of obesity on prostate cancer.
Increasing prevalence of obesity in many parts of the world emphasizes the importance of learning more about the relationship between obesity and prostate cancer (PC). The present paper reviews the impact of obesity on PC using knowledge obtained from the available literature. Search of published literature in PUBMED database. Adipose tissue constitutes an active endocrine and metabolic organ which may be relevant in the development and progression of PC by different potential mechanisms. Furthermore, obesity could have an impact on the outcome of different treatment modalities for PC, both functionally as anatomically. Obesity is a growing problem, however, the exact role in the development and progression of PC has not been elucidated. Regarding the optimal treatment of PC in obese patients, comparative prospective studies are needed.
van Roermund
Joep G H
JG
Department of Urology, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands. F.Witjes@uro.umcn.nl
Witjes
J Alfred
JA
D015992:Body Mass Index; D000075202:Contraindications; D012739:Gonadal Steroid Hormones / Q000502:physiology; D006801:Humans; D008297:Male; D009765:Obesity / Q000150:complications / Q000503:physiopathology; D011446:Prospective Studies; D011468:Prostatectomy / Q000534:rehabilitation; D011471:Prostatic Neoplasms / Q000150:complications / Q000503:physiopathology; D049629:Waist-Hip Ratio
D012739:Gonadal Steroid Hormones