title: Estimation of the scattering coefficients of turbid media using angle-resolved optical frequency-domain imaging.
abstract: Noninvasive measurements of the scattering coefficients of optically turbid media using angle-resolved optical frequency-domain imaging (OFDI) are demonstrated. It is shown that, by incoherently averaging OFDI reflectance signals acquired at different backscattering angles, speckle noise is reduced, allowing scattering coefficients to be extracted from a single A-line with much higher accuracy than with measurements from conventional OFDI and optical coherence tomography systems. Modeling speckle as a random phasor sum, the relationship between the measurement accuracy and the number of compounded angles is derived. The sensitivity analysis is validated with measurements from a tissue phantom.
authors.affiliation: Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA. adesjard@mit.edu
authors.forename: A E
authors.initials: AE
authors.lastname: Desjardins
authors.forename: B J
authors.initials: BJ
authors.lastname: Vakoc
authors.forename: A
authors.initials: A
authors.lastname: Bilenca
authors.forename: G J
authors.initials: GJ
authors.lastname: Tearney
authors.forename: B E
authors.initials: BE
authors.lastname: Bouma
mesh_terms: D002138:Calibration; D016014:Linear Models; D015233:Models, Statistical; D055095:Optics and Photonics; D019047:Phantoms, Imaging; D011336:Probability; D012031:Refractometry; D012044:Regression Analysis; D015203:Reproducibility of Results; D012542:Scattering, Radiation; D041623:Tomography, Optical Coherence / Q000379:methods*