title: Acute insomnia following surgery of the ventralis intermedius nucleus of the thalamus for tremor.
abstract: Stereotactic surgery with lesioning or deep brain stimulation directed to the ventralis intermedius nucleus of the thalamus is a well-recognized treatment for medically intractable tremor. A patient developed the rare complication of severe insomnia, easy awakening, and lack of slow-wave sleep after thalamotomy/deep brain stimulation implantation. This complication underscores the role of thalamic regulation on initiation and maintenance of sleep.
authors.affiliation: Department of Neurology, University of Virginia, Charlottesville, VA 22908, USA. quigg@virginia.edu
authors.forename: Mark
authors.initials: M
authors.lastname: Quigg
authors.forename: Robert C
authors.initials: RC
authors.lastname: Frysinger
authors.forename: Madaline
authors.initials: M
authors.lastname: Harrison
authors.forename: W Jeffrey
authors.initials: WJ
authors.lastname: Elias
mesh_terms: D000208:Acute Disease; D000368:Aged; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D020644:Midline Thalamic Nuclei / Q000033:anatomy & histology* / Q000601:surgery*; D019635:Neurosurgical Procedures / Q000379:methods; D017286:Polysomnography; D011183:Postoperative Complications; D007319:Sleep Initiation and Maintenance Disorders / Q000175:diagnosis / Q000209:etiology*; D012894:Sleep Stages / Q000502:physiology; D014202:Tremor / Q000175:diagnosis / Q000503:physiopathology* / Q000601:surgery*; D020651:Ventral Thalamic Nuclei / Q000033:anatomy & histology* / Q000601:surgery*