Clinical implications of steroid receptor coactivator (SRC)-3 in uterine endometrial cancers.
Estrogen is recognized as a significant modifier in the development, growth and invasion of uterine endometrial cancer. Steroid receptor coactivator-3 (SRC-3; AIB1, ACTR, RAC3, TRAM-1, and pCIP) is a member of the p160 family of coactivator for nuclear hormone receptors including estrogen receptor (ER). It is reported that SRC-3 is overexpressed in various cancers. However, SRC-3 expression manner in uterine endometrial cancer is not fully understood. In this study, we showed SRC-3 mRNA expression correlates with clinical stage, depth of myometrial invasion and dedifferentiation. The prognosis of the 25 patients with higher expression of SRC-3 mRNA in uterine endometrial cancers was extremely poor (36%), whereas the 24-month survival rate of the 15 patients with lower expression of SRC-3 mRNA was 96%. These data indicate that SRC-3 might be an important indicator of uterine endometrial cancer advancement and survival.
Sakaguchi
Hideki
H
Department of Obstetrics and Gynecology, Gifu University School of Medicine, 1-1 Yanagido, Gifu City 501-1194, Japan. gucci555@nifty.com
Fujimoto
Jiro
J
Sun
Wen-Shu
WS
Tamaya
Teruhiko
T
D000328:Adult; D000368:Aged; D018269:Carcinoma, Endometrioid / Q000175:diagnosis* / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D018450:Disease Progression; D016889:Endometrial Neoplasms / Q000175:diagnosis* / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D051548:Histone Acetyltransferases / Q000235:genetics*; D006801:Humans; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D056921:Nuclear Receptor Coactivator 3; D011379:Prognosis; D015996:Survival Rate; D015534:Trans-Activators / Q000235:genetics*
D015534:Trans-Activators; D051548:Histone Acetyltransferases; C538866:NCOA3 protein, human; D056921:Nuclear Receptor Coactivator 3