Neolemnane-type sesquiterpenoids from a formosan soft coral Paralemnalia thyrsoides.
Six new sesquiterpenoids, paralemnolins D-I (1-6), have been isolated from the EtOAc extract of the soft coral Paralemnalia thyrsoides. The structures of these metabolites were determined by extensive spectroscopic analysis and by comparison of their spectral data with those of related metabolites. The absolute stereochemistry of these metabolites was established by application of the Mosher's method on 1 and on the basis of the absolute structures of other related compounds previously isolated from the soft corals of the genera Paralemnalia and Lemnalia. Cytotoxicity of these metabolites toward a limited panel of cancer cell lines also is reported.
Huang
Ho-Cheng
HC
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung, Taiwan.
Chao
Chih-Hua
CH
Su
Jui-Hsin
JH
Hsu
Chi-Hsin
CH
Chen
Shin-Pin
SP
Kuo
Yao-Haur
YH
Sheu
Jyh-Horng
JH
D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification*; D021241:Spectrometry, Mass, Electrospray Ionization
D012717:Sesquiterpenes