Cardiovascular risk factors in peritoneal dialysis patients revisited.
End-stage renal disease patients are at a heightened risk of developing cardiovascular disease, with contributions from both "traditional" and "nontraditional" cardiovascular risk factors. Some of the nontraditional risk factors, such as extracellular volume overload, inflammation, and hyperphosphatemia, have also been shown to be important predictors of mortality in the dialysis population. This article provides an in-depth review of the evidence that supports the substantial contributions of nontraditional risk factors to adverse cardiovascular outcomes in chronic peritoneal dialysis patients. In addition, it provides evidence to demonstrate how loss of residual renal function may be central to the development of cardiovascular disease in the peritoneal dialysis population.
Wang
Angela Yee-Moon
AY
University Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong SAR, PR China. aymwang@hku.hk
D002114:Calcinosis; D002318:Cardiovascular Diseases / Q000209:etiology*; D006801:Humans; D007249:Inflammation / Q000209:etiology; D007668:Kidney / Q000503:physiopathology*; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000628:therapy*; D010530:Peritoneal Dialysis / Q000009:adverse effects*; D010710:Phosphates / Q000378:metabolism; D012307:Risk Factors
D010710:Phosphates