title: Double-strand break generation under deoxyribonucleotide starvation in Escherichia coli.
abstract: Stalled replication forks produced by three different ways of depleting deoxynucleoside triphosphate showed different capacities to undergo "replication fork reversal." This reaction occurred at the stalled forks generated by hydroxyurea treatment, was impaired under thermal inactivation of ribonucleoside reductase, and did not take place under thymine starvation.
authors.affiliation: Departamento de Bioquímica, Biología Molecular y Genética, Facultad de Ciencias, Universidad de Extremadura, 06080-Badajoz, Spain.
authors.forename: Estrella
authors.initials: E
authors.lastname: Guarino
authors.forename: Israel
authors.initials: I
authors.lastname: Salguero
authors.forename: Alfonso
authors.initials: A
authors.lastname: Jiménez-Sánchez
authors.forename: Elena C
authors.initials: EC
authors.lastname: Guzmán
mesh_terms: D053903:DNA Breaks, Double-Stranded; D004261:DNA Replication; D004269:DNA, Bacterial / Q000235:genetics* / Q000378:metabolism; D003854:Deoxyribonucleotides / Q000378:metabolism*; D004926:Escherichia coli / Q000235:genetics* / Q000378:metabolism*; D012262:Ribonucleoside Diphosphate Reductase / Q000378:metabolism
chemical_list: D004269:DNA, Bacterial; D003854:Deoxyribonucleotides; D012262:Ribonucleoside Diphosphate Reductase