Mortality risks among heavy-smokers with special reference to women: a long-term follow-up of an urban population.
Increased mortality risks associated with smoking are well established among men. There are very few population-based studies comprising a sufficient number of heavily smoking women, measuring the direct effect of smoking on mortality risks. Between 1974 and 1992, 8,499 women and 13,888 men attended a health screening programme including reporting of smoking habits. Individuals were followed for total mortality until 2005. All-cause, cancer, cardiovascular, lung cancer and respiratory mortality were calculated in smoking categories <10 g per day, 10-19 g per day, and > or =20 g per day with never-smokers as a reference group and with adjustments for co-morbidities, socio-economic and marital status. For respiratory mortality and lung cancer adjustments for FEV(1), socio-economic and marital status were performed. Smoking was associated with a two to almost threefold increased mortality risk among women and men. The relative risk (RR) with 95% confidence interval, (CI) for women who smoked 10-19 g per day was 2.44 (2.07-2.87), and for those who smoked 20 g per day or more the RR (95% CI) was 2.42 (2.00-2.92). Smoking was a strong risk factor for cardiovascular mortality among women, the RR (95% CI) for women who smoked 10-19 g per day was 4.52 (3.07-6.64). Ex-smoking women showed increased risks of all-cause mortality; RR (95% CI) 1.26 (1.04-1.52) cancer (excluding lung cancer); RR (95% CI) 1.42 (1.07-1.88) and lung cancer RR (95% CI) 2.71 (1.02-7.23) mortality. However, the cardiovascular; RR (95% CI) 1.18 (0.69-2.00) and respiratory; RR (95% CI) 0.79 (0.16-3.84) mortality risks were not statistically significant. This study confirms that as for men, middle-aged heavily smoking women have a two to threefold increased mortality risk. Adjustments for co-morbidity, socio-economic and marital status did not change these results.
Ekberg-Aronsson
M
M
Department of Respiratory Medicine and Allergology, Lund University Hospital, University of Lund, Lund, 221 85, Sweden. marie.ekberg-aronsson@med.lu.se
Nilsson
P M
PM
Nilsson
J-A
JA
Löfdahl
C-G
CG
Löfdahl
K
K
D000328:Adult; D002318:Cardiovascular Diseases / Q000401:mortality; D005260:Female; D006801:Humans; D008171:Lung Diseases / Q000503:physiopathology; D008297:Male; D017533:Marital Status; D008875:Middle Aged; D012131:Respiratory Insufficiency / Q000401:mortality; D018570:Risk Assessment; D012907:Smoking / Q000453:epidemiology / Q000401:mortality*; D012923:Social Class; D013548:Sweden / Q000453:epidemiology; D014505:Urban Population