title: Lysosomal hydrolases in cerebrospinal fluid from subjects with Parkinson's disease.
abstract: Recent studies have shown a genetic association between glucocerebrosidase deficiencies and Parkinson's disease (PD). To further explore this issue the activity of beta-glucocerebrosidase and the activities of other lysosomal enzymes, alpha-mannosidase, beta-mannosidase, beta-hexosaminidase, and beta-galactosidase have been evaluated in the cerebrospinal fluid (CSF) of PD patients. The activities of alpha-mannosidase, beta-mannosidase, beta-glucocerebrosidase, and beta-hexosaminidase were substantially decreased in the CSF of PD patients, while levels of beta-galactosidase were essentially identical to controls. This study indicates that in PD several lysosomal hydrolases have decreased activities, further supporting a possible link between pathophysiological mechanisms underlying PD and lysosomal hydrolases.
authors.affiliation: Dipartimento di Medicina Interna, Università degli Studi di Perugia, Perugia, Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Balducci
authors.affiliation: Clinica Neurologica, Ospedale Santa Maria della Misericordia, Università degli Studi di Perugia, Perugia, Italy.|Fondazione Santa Lucia, IRCCS, Roma, Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: Pierguidi
authors.affiliation: Dipartimento di Medicina Interna, Università degli Studi di Perugia, Perugia, Italy.
authors.forename: Emanuele
authors.initials: E
authors.lastname: Persichetti
authors.affiliation: Clinica Neurologica, Ospedale Santa Maria della Misericordia, Università degli Studi di Perugia, Perugia, Italy.
authors.forename: Lucilla
authors.initials: L
authors.lastname: Parnetti
authors.affiliation: Dipartimento di Medicina Interna, Università degli Studi di Perugia, Perugia, Italy.
authors.forename: Michele
authors.initials: M
authors.lastname: Sbaragli
authors.affiliation: Dipartimento di Medicina Sperimentale e Scienze Biochimiche, Università degli Studi di Perugia, Perugia, Italy.
authors.forename: Carmelo
authors.initials: C
authors.lastname: Tassi
authors.affiliation: Dipartimento di Medicina Sperimentale e Scienze Biochimiche, Università degli Studi di Perugia, Perugia, Italy.
authors.forename: Aldo
authors.initials: A
authors.lastname: Orlacchio
authors.affiliation: Clinica Neurologica, Ospedale Santa Maria della Misericordia, Università degli Studi di Perugia, Perugia, Italy.|Fondazione Santa Lucia, IRCCS, Roma, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Calabresi
authors.affiliation: Dipartimento di Medicina Interna, Università degli Studi di Perugia, Perugia, Italy.
authors.forename: Tommaso
authors.initials: T
authors.lastname: Beccari
authors.affiliation: Clinica Neurologica, Ospedale Santa Maria della Misericordia, Università degli Studi di Perugia, Perugia, Italy.
authors.forename: Aroldo
authors.initials: A
authors.lastname: Rossi
mesh_terms: D000368:Aged; D002852:Chromatography, Ion Exchange / Q000379:methods; D005260:Female; D006801:Humans; D006821:Hyaluronoglucosaminidase / Q000134:cerebrospinal fluid*; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000134:cerebrospinal fluid*; D018709:Statistics, Nonparametric
chemical_list: D006821:Hyaluronoglucosaminidase