Unusual concurrent detection by polymerase chain reaction of Bartonella henselae and parvovirus b19 in an immunocompetent child with erythema nodosum and hepatic granulomatous disease.
We report an unusual case of documented Bartonella henselae genotype I from hepatic tissue in an Italian immunocompetent girl presenting with erythema nodosum and hepatic granulomata. Polymerase chain reaction (PCR) was performed on biopsied liver sample to confirm the etiologic role of B. henselae and to identify the genetic variant of this organism. A PCR on the same liver biopsy for parvovirus B19 was also positive, but the clinical meaning of this was not clear.
Casolari
Chiara
C
Department of Medical Laboratory and Legal Medicine, University of Modena and Reggio Emilia, Modena 41100, Italy. casolari.chiara@unimore.it
Pecorari
Monica
M
Balli
Fiorella
F
Fabio
Giuliana
G
Gennari
William
W
Sabbatini
Anna Maria Teresa
AM
Nanni
Nadia
N
Migaldi
Mario
M
Guaraldi
Nicola
N
Tagliazucchi
Sara
S
Alù
Milena
M
Bertoli
Gabriella
G
Fabio
Rumpianesi
R
Portolani
Marinella
M
D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001474:Bartonella Infections / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D018416:Bartonella henselae / Q000145:classification / Q000235:genetics*; D002675:Child, Preschool; D017291:Clarithromycin / Q000627:therapeutic use; D004893:Erythema Nodosum / Q000188:drug therapy / Q000209:etiology*; D005260:Female; D006099:Granuloma / Q000188:drug therapy / Q000382:microbiology; D006801:Humans; D007121:Immunocompetence; D008107:Liver Diseases / Q000188:drug therapy / Q000382:microbiology; D010322:Parvoviridae Infections / Q000150:complications / Q000175:diagnosis / Q000235:genetics; D016732:Parvovirus B19, Human / Q000235:genetics*; D016133:Polymerase Chain Reaction
D000900:Anti-Bacterial Agents; D017291:Clarithromycin