title: Nonsporulating clinical isolate identified as Petromyces alliaceus (anamorph Aspergillus alliaceus) by morphological and sequence-based methods.
abstract: Concerted morphological and sequencing-based strategies revealed the identity of a nonsporulating clinical isolate as Petromyces alliaceus (anamorph Aspergillus alliaceus). This rare Aspergillus sp. was recovered as the etiological agent of invasive pulmonary aspergillosis and had reduced in vitro susceptibilities to amphotericin B and caspofungin, which correlated with clinical failure of therapy.
authors.affiliation: Mycotic Diseases Branch, Centers for Disease Control and Prevention, Mail Stop-G 11, 1600 Clifton Road, Atlanta, GA 30333, USA. fir3@cdc.gov
authors.forename: S Arunmozhi
authors.initials: SA
authors.lastname: Balajee
authors.forename: Mark D
authors.initials: MD
authors.lastname: Lindsley
authors.forename: Naureen
authors.initials: N
authors.lastname: Iqbal
authors.forename: James
authors.initials: J
authors.lastname: Ito
authors.forename: Peter G
authors.initials: PG
authors.lastname: Pappas
authors.forename: Mary E
authors.initials: ME
authors.lastname: Brandt
mesh_terms: D000666:Amphotericin B / Q000494:pharmacology; D000935:Antifungal Agents / Q000494:pharmacology; D001229:Aspergillosis, Allergic Bronchopulmonary / Q000188:drug therapy / Q000382:microbiology*; D001230:Aspergillus / Q000166:cytology* / Q000187:drug effects / Q000235:genetics* / Q000302:isolation & purification; D000077336:Caspofungin; D004271:DNA, Fungal / Q000737:chemistry / Q000235:genetics; D004275:DNA, Ribosomal / Q000737:chemistry / Q000235:genetics; D021903:DNA, Ribosomal Spacer / Q000737:chemistry / Q000235:genetics; D054714:Echinocandins; D005260:Female; D006801:Humans; D055666:Lipopeptides; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D008969:Molecular Sequence Data; D010456:Peptides, Cyclic / Q000494:pharmacology; D012339:RNA, Ribosomal, 28S / Q000235:genetics; D017422:Sequence Analysis, DNA; D012689:Sequence Homology, Nucleic Acid
chemical_list: D000935:Antifungal Agents; D004271:DNA, Fungal; D004275:DNA, Ribosomal; D021903:DNA, Ribosomal Spacer; D054714:Echinocandins; D055666:Lipopeptides; D010456:Peptides, Cyclic; D012339:RNA, Ribosomal, 28S; D000666:Amphotericin B; D000077336:Caspofungin