Proton beam therapy for hepatocellular carcinoma with inferior vena cava tumor thrombus: report of three cases.
Three patients with hepatocellular carcinoma (HCC) and inferior vena cava tumor thrombus (IVCTT) were treated using proton beam therapy at the University of Tsukuba, Japan. A total dose of 50-70 Gy in 10-35 fractions was given to the primary tumor and IVCTT. All the patients survived for more than 1 year from the beginning of proton beam therapy (13-55 months) and no treatment-related toxicity of grade 3 or higher was observed. These cases suggest that proton beam therapy is safe and effective for patients with HCC associated with IVCTT.
Mizumoto
Masashi
M
Proton Medical Research Center, University of Tsukuba, Tennoudai, Tsukuba, Ibaraki, Japan. mizumoto@pmrc.tsukuba.ac.jp
Tokuuye
Koichi
K
Sugahara
Shinji
S
Hata
Masaharu
M
Fukumitsu
Nobuyoshi
N
Hashimoto
Takayuki
T
Ohnishi
Kayoko
K
Nemoto
Keiko
K
Ohara
Kiyoshi
K
Matsuzaki
Yasushi
Y
Tohno
Eriko
E
Akine
Yasuyuki
Y
D006528:Carcinoma, Hepatocellular / Q000000981:diagnostic imaging / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged; D009360:Neoplastic Cells, Circulating / Q000528:radiation effects*; D061766:Proton Therapy; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014682:Vena Cava, Inferior; D011522:Protons
D011522:Protons