The roles of mesenchymal stem cells (MSCs) therapy in ischemic heart diseases.
Growing cell-based myocardial therapies which could lead to successful myocardial repair attracts medical interest. Even more intriguing is the observation that MSCs appears to be a more potent material among kinds of stem cells for the transplantation, the mechanism for this benefit remains unclear. However, the therapeutic contribution of MSCs to myocardial repair can be caused by multiple factors including: direct differentiation into cardiac tissue including cardiomyocytes, smooth muscle cell, and vascular endothelial cells; secreting a variety of cytokines and growth factors that have paracrine activities; spontaneous cell fusion; and stimulating endogenous repair. In addition, MSCs possess local immunosuppressive properties, and MSCs mobilization is widely used clinically for transplantation. We will discusses the potential mechanisms of MSCs repair for ischemic heart diseases.
Wang
Xiao-Jun
XJ
Department of Pharmacology, Nanjing Medical University, Nanjing, China.
Li
Qing-Ping
QP
D000818:Animals; D017690:Cell Transplantation; D016207:Cytokines / Q000378:metabolism; D042783:Endothelial Cells / Q000166:cytology; D004730:Endothelium, Vascular / Q000166:cytology; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods*; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D017202:Myocardial Ischemia / Q000473:pathology* / Q000628:therapy*; D009206:Myocardium / Q000378:metabolism; D032389:Myocytes, Smooth Muscle / Q000166:cytology; D009474:Neurons / Q000378:metabolism
D016207:Cytokines; D007166:Immunosuppressive Agents; D036341:Intercellular Signaling Peptides and Proteins