title: Combined xeno/auto-grafting of a benign osteolytic lesion in a dog, using a novel bovine cancellous bone biomaterial.
abstract: METHODS
  A 4-year-old female Labrador Retriever was diagnosed with an osteolytic lesion of the right distal radius.
  
  
  RESULTS
  Radiographs indicated a well-circumscribed radiolucent area 18 x 15 x 8 mm, centred on the distal radial physeal scar.
  
  
  METHODS
  Histopathology, performed via Jamshidi needle biopsy and following surgical curettage, was inconclusive but suggested either an aneurysmal bone cyst or fibrous dysplasia.
  
  
  CONCLUSIONS
  A novel processed cancellous bovine bone xenograft was used in conjunction with autogenous cancellous bone (at a ratio of approximately 4:1) to fill the curetted defect. There were no observed complications associated with the use of this new biomaterial. Osteointegration of the bone graft was followed using conventional radiographs and peripheral quantitative computed tomography (pQCT) for 10 months post-operatively. Radiographically, the osteolytic lesion modelled to resemble metaphyseal trabeculation. The cross-sectional area and the average bone density of the grafted lesion determined using pQCT data increased over time, suggesting healthy osteoconduction and native bone production.
authors.affiliation: Centre for Companion Animal Health, Institute of Veterinary, Animal and Biomedical Sciences, Massey University, Palmerston North, New Zealand. a.j.worth@massey.ac.nz
authors.forename: A J
authors.initials: AJ
authors.lastname: Worth
authors.forename: K G
authors.initials: KG
authors.lastname: Thompson
authors.forename: M C
authors.initials: MC
authors.lastname: Owen
authors.forename: M R
authors.initials: MR
authors.lastname: Mucalo
authors.forename: E C
authors.initials: EC
authors.lastname: Firth
mesh_terms: D000818:Animals; D016025:Bone Transplantation / Q000379:methods / Q000662:veterinary*; D004285:Dogs / Q000601:surgery; D005260:Female; D011859:Radiography; D011884:Radius / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery / Q000637:transplantation*; D014182:Transplantation, Autologous / Q000379:methods / Q000662:veterinary*; D014183:Transplantation, Heterologous / Q000379:methods / Q000662:veterinary*; D016896:Treatment Outcome