title: Beta2-adrenergic receptor gene polymorphisms and risk of ischemic stroke.
abstract: BACKGROUND
  Beta2-adrenergic receptors (beta2-AR) mediate vasorelaxation in response to adrenergic agents. Genetic polymorphisms of beta2-AR were implicated in various cardiovascular and noncardiovascular traits.
  
  
  METHODS
  We tested the role of the beta2AR-16 and beta2AR-27 gene variants in the susceptibility to the development of ischemic stroke in a genetically homogenous and clinically well-characterized case-control sample that included 294 cases and 286 controls from Sardinia, Italy. This population was shown to be an optimal study sample for carrying out genetic analyses.
  
  
  RESULTS
  Age, hypertension, dyslipidemia, and atrial fibrillation were independent risk factors for stroke in this cohort. We found that the presence of the Glu27 allelic variant was associated with a significantly increased risk of stroke when assuming a recessive mode of inheritance (odds ratio [OR], 1.68; 95% confidence interval [CI], 1.17-2.41; P = .005). The same results were obtained for the subgroup of ischemic strokes of arterial origin (n = 215): OR, 1.71; 95% CI, 1.14-2.57; P = .009. Furthermore, haplotype analysis confirmed that the presence of the Glu27 allele increased the risk of cerebrovascular accidents.
  
  
  CONCLUSIONS
  Our data suggest that the Glu27 allelic variant of the beta2-AR gene may be a determinant of ischemic stroke.
authors.affiliation: Istituto di Ricovero e Cura a Carattere Scientifico Neuromed, University La Sapienza, Rome, Italy.
authors.forename: Rosita
authors.initials: R
authors.lastname: Stanzione
authors.forename: Emanuele
authors.initials: E
authors.lastname: Di Angelantonio
authors.forename: Anna
authors.initials: A
authors.lastname: Evangelista
authors.forename: Daniela
authors.initials: D
authors.lastname: Barbato
authors.forename: Simona
authors.initials: S
authors.lastname: Marchitti
authors.forename: Bastianina
authors.initials: B
authors.lastname: Zanda
authors.forename: Angelo
authors.initials: A
authors.lastname: Pirisi
authors.forename: Giovanni
authors.initials: G
authors.lastname: Quarta
authors.forename: Massimo
authors.initials: M
authors.lastname: Volpe
authors.forename: Speranza
authors.initials: S
authors.lastname: Rubattu
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D016022:Case-Control Studies; D004247:DNA / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D018698:Glutamic Acid; D005973:Glutamine; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D018343:Receptors, Adrenergic, beta-2 / Q000235:genetics*; D012307:Risk Factors; D020521:Stroke / Q000453:epidemiology / Q000235:genetics*
chemical_list: D018343:Receptors, Adrenergic, beta-2; D005973:Glutamine; D018698:Glutamic Acid; D004247:DNA