title: Two new xanthones isolated from the stem bark of Garcinia lancilimba.
abstract: Two new xanthones, 1,5,6-trihydroxy-6',6'-dimethyl-2H-pyrano(2',3':3,4)-2-(3-methylbut-2-enyl)xanthone (1) and 1,6,7-trihydroxy-6',6'-dimethyl-2H-pyrano(2',3':3,2)-4-(3-methylbut-2-enyl)xanthone (2), have been isolated from the stem bark of Garcinia lancilimba (Guttiferae), together with six known xanthones. Their structures were identified on the basis of extensive spectral evidence including detailed 2D NMR and HR-MS data. Two new compounds showed moderate inhibitory effect on human breast cancer MDA-MB-435S cell line.
authors.affiliation: Chinese Medicine Laboratory, Hong Kong Jockey Club Institute of Chinese Medicine, Hong-Kong, PR China.
authors.forename: Nian-Yun
authors.initials: NY
authors.lastname: Yang
authors.forename: Quan-Bin
authors.initials: QB
authors.lastname: Han
authors.forename: Xin-Wei
authors.initials: XW
authors.lastname: Cao
authors.forename: Chun-Feng
authors.initials: CF
authors.lastname: Qiao
authors.forename: Jing-Zheng
authors.initials: JZ
authors.lastname: Song
authors.forename: Shi-Lin
authors.initials: SL
authors.lastname: Chen
authors.forename: Da-Jian
authors.initials: DJ
authors.lastname: Yang
authors.forename: Hillary
authors.initials: H
authors.lastname: Yiu
authors.forename: Hong-Xi
authors.initials: HX
authors.lastname: Xu
mesh_terms: D045744:Cell Line, Tumor; D029760:Garcinia / Q000737:chemistry*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D018547:Plant Stems / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D044004:Xanthones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D044004:Xanthones