TCMS inhibits ATP synthesis in mitochondria: a systematic analysis of the inhibitory mechanism.
The interactions of the antifouling compound TCMS (2,3,5,6-tetrachloro-4-methylsulphonyl pyridine) with rat liver mitochondria have been investigated. The results indicate that the compound inhibits ATP synthesis. Further investigations regarding the ATP synthesis mechanism suggest that TCMS inhibits succinic dehydrogenase of the mitochondrial respiratory chain. As the respiratory chain is similar in all living organisms, it can be concluded that the toxic effect of TCMS most likely depend on the different bioavailability of the compound and on the different importance of mitochondria in the ATP production in the animal species.
Bragadin
Marcantonio
M
Environmental Sciences Department, Ca' Foscari University of Venice, Dorsoduro 2137, 30123 Venice, Italy. bragadin@unive.it
Iero
Alessandra
A
Cima
Francesca
F
Ballarin
Loriano
L
Manente
Sabrina
S
D000255:Adenosine Triphosphate / Q000037:antagonists & inhibitors* / Q000378:metabolism; D000818:Animals; D004579:Electron Transport / Q000187:drug effects; D006863:Hydrogen-Ion Concentration; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000378:metabolism; D010100:Oxygen / Q000378:metabolism; D011725:Pyridines / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D013450:Sulfones / Q000633:toxicity*
D011725:Pyridines; D013450:Sulfones; C484946:2,3,5,6-tetrachloro-4-(methylsulfonyl)pyridine; D000255:Adenosine Triphosphate; D010100:Oxygen