[Study on the distribution of Y chromosome haplogroups in Sichuan Han population].
OBJECTIVE
To investigate the distribution characteristics of Y chromosome haplogroups in Sichuan Han population.


METHODS
Using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), denatured high performance liquid chromatography (DHPLC) and DNA sequencing methods, 18 Y-chromosome bialletic markers were detected to type Y chromosome haplogroups in 341 unselected men from Sichuan Han population.


RESULTS
A total of 14 haplogroups were observed, in which haplogroups H2 and H4 were identified for the first time in Sichuan population, and haplogroups H14 and N* were found firstly in Chinese. There was a significant frequency difference of Y haplogroups between Sichuan Han population and Southern Han population.


CONCLUSIONS
More comprehensive frequency distribution data of Y chromosome haplogroups are obtained in Sichuan Han population, which would be helpful for understanding the association of Y chromosome background and the susceptibility to male specific diseases such as spermatogenic failure, prostate cancer, testical cancer and so on in present population.
Ma
Ming-yi
MY
Department of Medical Genetics, West China Hospital, Sichuan University, Division of Human Morbids Genomics, State Key Laboratory of Biotherapy, Sichuan University, Chengdu, Sichuan, 610041 PR China.
Yang
Yuan
Y
Xiao
Cui-ying
CY
Zhang
Si-zhong
SZ
D044466:Asian People / Q000235:genetics*; D002681:China / Q000208:ethnology; D041322:Chromosomes, Human, Y / Q000235:genetics*; D004591:Electrophoresis, Polyacrylamide Gel; D005006:Ethnicity / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000208:ethnology; D006239:Haplotypes / Q000235:genetics*; D006801:Humans; D008297:Male; D009154:Mutation