title: [Correlation between MHC class I-related chain A gene *008 allele and human cytomegalovirus infection].
abstract: OBJECTIVE
  To investigate the correlation between MHC class I-related chain A (MICA) gene *008 allele and human cytomegalovirus (HCMV) infection.
  
  
  METHODS
  MICA*008 allele was detected in 86 patients with chronic granulocytic leukemia and 81 unrelated normal individuals by way of sequence-specific primers (PCR-SSP). Anti-HCMV IgM was also detected in the sera of these subjects with enzyme linked immunosorbent assay (ELISA).
  
  
  RESULTS
  MICA*008 allele frequency was lower in patients with chronic granulocytic leukemia than in the control group (22.2% vs 34.3%, Chi(2)=4.98, P<0.05). The infection rate of HCMV was significantly higher in those individuals with genotype of MICA*008 (-) than in those with MICA*008 (+), and moderate correlation was suggested between MICA*008 and HCMV infection (C=0.5829, 0.6142).
  
  
  CONCLUSIONS
  Individuals with MICA*008 positivity is not liable to HCMV infection, but those with MICA*008 (-) can be vulnerable to HCMV infection, suggesting an inverse correlation between MICA*008 allele with HCMV.
authors.affiliation: Department of Physiology, Xiangya School of Medicine, Central South University, Changsha 410078, China. huangbs2078@163.com
authors.forename: Bai-sheng
authors.initials: BS
authors.lastname: Huang
authors.forename: Qi-zhi
authors.initials: QZ
authors.lastname: Luo
authors.forename: Bing
authors.initials: B
authors.lastname: Mei
authors.forename: Ping
authors.initials: P
authors.lastname: Yu
mesh_terms: D000483:Alleles; D003586:Cytomegalovirus Infections / Q000235:genetics*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics / Q000821:virology
chemical_list: D015395:Histocompatibility Antigens Class I; C099187:MHC class I-related chain A