title: Interleukin-6-producing giant cell carcinoma of the lung with multicentric Castleman's disease-like presentation.
abstract: We encountered a 59-year-old man with advanced lung cancer with multiple swollen lymph nodes. At autopsy the lung cancer was revealed as giant cell carcinoma. Microscopic examination showed no cancer cells, but there was polyclonal proliferation of plasma cells in the lymph nodes and in the bone marrow. In the kidneys, proliferation of mesangial matrices and mesangial cells was found. This presentation resembled multicentric Castleman's disease (MCD), in which interleukin-6 (IL-6) has a great role. Immunohistochemical staining was positive for IL-6 in cancer cells. This is the first reported case of an IL-6-producing giant cell carcinoma of the lung with MCD-like presentation.
authors.affiliation: Division of Internal Medicine, Center for Respiratory Diseases, Mitsui Memorial Hospital, Tokyo, Japan.
authors.forename: Yasutomi
authors.initials: Y
authors.lastname: Higashikuni
authors.forename: Masaya
authors.initials: M
authors.lastname: Mori
authors.forename: Hiroyoshi
authors.initials: H
authors.lastname: Kino
mesh_terms: D001344:Autopsy; D001707:Biopsy, Needle; D018286:Carcinoma, Giant Cell / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology*; D005871:Castleman Disease / Q000175:diagnosis* / Q000473:pathology; D003937:Diagnosis, Differential; D006801:Humans; D015850:Interleukin-6 / Q000378:metabolism*; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology*; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010950:Plasma Cells / Q000378:metabolism / Q000473:pathology
chemical_list: D015850:Interleukin-6