title: (3R,4aR,5S,6R)-6-Hydroxy-5-methylramulosin: a new ramulosin derivative from a marine-derived sterile mycelium.
abstract: (3R,4aR,5S,6R)-6-Hydroxy-5-methylramulosin (1) was isolated from a culture of a sterile mycelium, which was derived from the green alga, Codium fragile, along with (-)-5-methylmellein (2), (-)-5-hydroxymethylmellein (3), and (-)-(3R,4R)-cis-4-hydroxy-5-methylmellein (4). The absolute configuration of 1 was determined by the NMR data along with the lactone sector rule by circular dichroism (CD). Compound 1 exhibited moderate cytotoxic activity against HeLa cells.
authors.affiliation: Graduate School of Natural Science and Technology, Kanazawa University, Kakuma-machi, Kanazawa, Japan.
authors.forename: Ahmed Atef
authors.initials: AA
authors.lastname: El-Beih
authors.forename: Hikaru
authors.initials: H
authors.lastname: Kato
authors.forename: Tomihisa
authors.initials: T
authors.lastname: Ohta
authors.forename: Sachiko
authors.initials: S
authors.lastname: Tsukamoto
mesh_terms: D002942:Circular Dichroism; D049934:Isocoumarins / Q000737:chemistry / Q000302:isolation & purification*; D009682:Magnetic Resonance Spectroscopy; D025282:Mycelium / Q000737:chemistry*; D016339:Spectrometry, Mass, Fast Atom Bombardment
chemical_list: C521876:6-hydroxy-5-methylramulosin; D049934:Isocoumarins