title: Current treatment strategies in elderly patients with metastatic colorectal cancer.
abstract: Colorectal cancer (CRC) is one of the most common cancers in the Western world, with > 500,000 new cases diagnosed each year. One of the strongest risk factors for colon cancer is age. The incidence rates rise from 10 in 100,000 at age 40-45 years to 300 in 100,000 at age 75-80 years, with the median age at diagnosis of CRC being 71 years. With the general demographic shift toward an aging population, the number of people aged > 65 years is expected to increase. This article reviews the development of treatment for elderly patients with metastatic CRC, from single-agent fluoropyrimidines to combination therapies.
authors.affiliation: Department of Medical Oncology, Royal Marsden Hospital-London and Sutton, Surrey, United Kingdom.
authors.forename: Hendrik-Tobias
authors.initials: HT
authors.lastname: Arkenau
authors.forename: Yu Jo
authors.initials: YJ
authors.lastname: Chua
authors.forename: David
authors.initials: D
authors.lastname: Cunningham
mesh_terms: D000368:Aged; D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000556:secondary; D006801:Humans
chemical_list: D000970:Antineoplastic Agents