title: Association study of a functional variant in intron 8 of the dopamine transporter gene and migraine susceptibility.
abstract: Migraine is a common, genetically influenced neurovascular disorder. The dopamine transporter gene is a candidate for migraine association studies. This study tested a functionally linked variable number tandem repeat (VNTR) in intron 8 of the dopamine transporter gene (DAT(Int8)) in 550 migraine cases (401 with aura, 149 without aura) and 550 non-migraine controls. Chi-squared analysis of the DAT(Int8) revealed that the allele and genotype frequency distributions for migraine cases (including subtype analysis) and controls were not different (P > 0.1). These findings offer no evidence for an association of the DAT(Int8) with migraine with and without aura and therefore do not implicate the dopamine transporter gene as a modifier of migraine risk.
authors.affiliation: Environmental Science and Research Ltd, Wellington, New Zealand.
authors.forename: L K
authors.initials: LK
authors.lastname: McCallum
authors.forename: F
authors.initials: F
authors.lastname: Fernandez
authors.forename: S
authors.initials: S
authors.lastname: Quinlan
authors.forename: D P
authors.initials: DP
authors.lastname: Macartney
authors.forename: R A
authors.initials: RA
authors.lastname: Lea
authors.forename: L R
authors.initials: LR
authors.lastname: Griffiths
mesh_terms: D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D050483:Dopamine Plasma Membrane Transport Proteins / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D007438:Introns / Q000235:genetics*; D008297:Male; D008881:Migraine Disorders / Q000235:genetics*; D018598:Minisatellite Repeats / Q000235:genetics
chemical_list: D050483:Dopamine Plasma Membrane Transport Proteins