Fatal disseminated Acanthamoeba lenticulata infection in a heart transplant patient.
We report a fatal case of disseminated acanthamebiasis caused by Acanthamoeba lenticulata (genotype T5) in a 39-year-old heart transplant recipient. The diagnosis was based on skin histopathologic results and confirmed by isolation of the ameba from involved skin and molecular analysis of a partial 18S rRNA gene sequence (DF3).
Barete
Stéphane
S
Department of Dermatology and Allergy, Hôpital Tenon, Assistance Publique Hôpitaux de Paris, France. stephane.barete@psl.aphp.fr
Combes
Alain
A
de Jonckheere
Johan F
JF
Datry
Annick
A
Varnous
Shaïda
S
Martinez
Valérie
V
Ptacek
Sara García
SG
Caumes
Eric
E
Capron
Frédérique
F
Francès
Camille
C
Gibert
Claude
C
Chosidow
Olivier
O
D000048:Acanthamoeba / Q000145:classification / Q000235:genetics / Q000472:pathogenicity*; D000328:Adult; D000562:Amebiasis / Q000175:diagnosis / Q000276:immunology / Q000473:pathology; D000818:Animals; D004275:DNA, Ribosomal; D017809:Fatal Outcome; D016027:Heart Transplantation / Q000276:immunology*; D006801:Humans; D016867:Immunocompromised Host; D008297:Male; D008969:Molecular Sequence Data; D012876:Skin Diseases, Parasitic / Q000175:diagnosis / Q000235:genetics / Q000473:pathology*
D004275:DNA, Ribosomal