Effect of formoterol on allergen-induced cytokine synthesis by atopic asthmatics.
BACKGROUND
Effect of formoterol, long-acting beta(2 )agonists, on T cell cytokine synthesis was examined.


METHODS
Human peripheral blood mononuclear cells were obtained from atopic asthmatics, and stimulated with Dermatophagoidesfarinae extract. Various concentrations of formoterol were added from the start of some cultures. Cytokine production and cell proliferation were analyzed.


RESULTS
Allergen-induced IL-5, IL-13, and IFN-gamma production of PBMC were significantly suppressed by formoterol in a dose-dependent manner, whereas the proliferation response was not suppressed.


CONCLUSIONS
Formoterol downregulates T cell functions of atopic asthmatics in vitro.
Hashimoto
Tomomi
T
Clinical Research Center for Allergy and Rheumatology, National Sagamihara Hospital, Sagamihara, Kanagawa, Japan.
Kitamura
Noriko
N
Kobayashi
Noriaki
N
Suko
Matsunobu
M
Kaminuma
Osamu
O
Mori
Akio
A
D058666:Adrenergic beta-2 Receptor Agonists; D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000328:Adult; D000818:Animals; D039741:Antigens, Dermatophagoides / Q000494:pharmacology*; D001249:Asthma / Q000473:pathology*; D002478:Cells, Cultured / Q000187:drug effects / Q000378:metabolism; D015536:Down-Regulation / Q000187:drug effects*; D004983:Ethanolamines / Q000494:pharmacology*; D005260:Female; D000068759:Formoterol Fumarate; D005786:Gene Expression Regulation / Q000187:drug effects*; D006801:Humans; D007371:Interferon-gamma / Q000096:biosynthesis* / Q000235:genetics / Q000378:metabolism; D018793:Interleukin-13 / Q000096:biosynthesis* / Q000235:genetics / Q000378:metabolism; D015848:Interleukin-5 / Q000096:biosynthesis* / Q000235:genetics / Q000378:metabolism; D007963:Leukocytes, Mononuclear / Q000187:drug effects* / Q000378:metabolism; D008213:Lymphocyte Activation / Q000187:drug effects; D008297:Male; D039981:Pyroglyphidae / Q000276:immunology; D018418:Th2 Cells / Q000187:drug effects / Q000378:metabolism
D058666:Adrenergic beta-2 Receptor Agonists; D000318:Adrenergic beta-Agonists; D039741:Antigens, Dermatophagoides; D004983:Ethanolamines; C508599:IL5 protein, human; D018793:Interleukin-13; D015848:Interleukin-5; D007371:Interferon-gamma; D000068759:Formoterol Fumarate