Parinaud's oculoglandular syndrome due to herpes simplex virus type 1.
OBJECTIVE
To describe the clinical findings in a patient with Parinaud's oculoglandular syndrome as an uncommon manifestation of primary herpes simplex virus type 1 (HSV-1) infection.


METHODS
The clinical course, the laboratory findings, the therapy, and the outcome regarding a 14-year-old girl are described.


RESULTS
The culture and PCR detection of HSV-1 on conjunctiva and skin scrapings, along with seroconversion to HSV, confirmed the etiology. The oral and local acyclovir therapy led to a prompt improvement in the patient's symptoms.


CONCLUSIONS
The solitary ocular-glandular syndrome due to HSV-1 primary infection has never been reported before. Parinaud's oculoglandular syndrome is found in 5% of patients with cat-scratch disease and only on rare occasion associated with other conditions. Herpetic infection should be considered in the differential diagnosis of young patients with conjunctivitis, periorbital swelling, and painful preauricular and submandibular lymphadenopathy, combined with systemic symptoms of malaise and fever.
Parentin
Fulvio
F
Department of Surgery, Ophthalmology Unit, University of Trieste and IRCCS, Burlo Garofolo, Trieste, Italy. parentin@burlo.trieste.it
Molin
Gianna Dal
GD
D'Agaro
Pierlanfranco
P
Busetti
Marina
M
Campello
Cesare
C
D000212:Acyclovir / Q000627:therapeutic use; D000293:Adolescent; D000914:Antibodies, Viral / Q000032:analysis; D000998:Antiviral Agents / Q000627:therapeutic use; D004279:DNA, Viral / Q000032:analysis; D003937:Diagnosis, Differential; D015828:Eye Infections, Viral / Q000150:complications* / Q000188:drug therapy / Q000821:virology; D005260:Female; D005500:Follow-Up Studies; D006561:Herpes Simplex / Q000150:complications* / Q000188:drug therapy / Q000821:virology; D018259:Herpesvirus 1, Human / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D006801:Humans; D015835:Ocular Motility Disorders / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D016133:Polymerase Chain Reaction
D000914:Antibodies, Viral; D000998:Antiviral Agents; D004279:DNA, Viral; D000212:Acyclovir