16S rRNA methylase-producing, gram-negative pathogens, Japan.
To investigate the exact isolation frequency of 16S rRNA methylase-producing, gram-negative pathogenic bacteria, we tested 87,626 clinical isolates from 169 hospitals. Twenty-six strains from 16 hospitals harbored 16S rRNA methylase genes, which suggests sparse but diffuse spread of pan-aminoglycoside-resistant microbes in Japan.
Yamane
Kunikazu
K
National Institute of Infectious Diseases, Tokyo, Japan.
Wachino
Jun-ichi
J
Suzuki
Satowa
S
Shibata
Naohiro
N
Kato
Haru
H
Shibayama
Keigo
K
Kimura
Kouji
K
Kai
Kumiko
K
Ishikawa
Satoshi
S
Ozawa
Yoshiyuki
Y
Konda
Toshifumi
T
Arakawa
Yoshichika
Y
D000617:Aminoglycosides / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D003982:Dibekacin / Q000031:analogs & derivatives / Q000494:pharmacology; D024881:Drug Resistance, Bacterial; D016521:Electrophoresis, Gel, Pulsed-Field; D005260:Female; D006090:Gram-Negative Bacteria / Q000187:drug effects* / Q000201:enzymology* / Q000235:genetics / Q000302:isolation & purification; D016905:Gram-Negative Bacterial Infections / Q000382:microbiology*; D006801:Humans; D007564:Japan; D008780:Methyltransferases / Q000235:genetics*; D008826:Microbial Sensitivity Tests; D012336:RNA, Ribosomal, 16S / Q000235:genetics
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D012336:RNA, Ribosomal, 16S; D003982:Dibekacin; D008780:Methyltransferases; C035181:rRNA (adenosine-O-2'-)methyltransferase; C031986:arbekacin