title: Pulpal responses after application of current adhesive systems to deep cavities.
abstract: The aim of the present study was to evaluate comparatively the pulpal tissue reactions of four adhesive systems placed in experimental cavities of healthy dog's teeth. Class V cavities with a mean value of remaining dentin thickness (RDT) ranging between 0.55 +/- 0.30-0.68 +/- 0.38 mm were prepared. The cavities were treated with the following adhesive systems: Etch and Prime 3.0 (EP), Single Bond (SB), Clearfil SE Bond (CSE), and Prompt L-Pop (PLP). The pulpal tissue responses to dentin adhesives were assessed histopathologically at postoperative periods of 7, 21, and 65 days, and the results were subjected to statistical analysis. A significantly greater adverse inflammatory response was observed with the materials EP and PLP, while a significantly lesser degree of disorganization in the odontoblastic zone was found with the materials SB and CSE, in the postoperative period of 65 days. In addition, a thicker predentin zone was observed where SB material was applied. Application of the selected adhesive systems to non-exposed cavities, with an RDT, which ranged between the above-mentioned rates, was correlated with slight to moderate inflammation and odontoblast reduction depending on the materials used as well as upon the RDT.
authors.affiliation: Department of Operative Dentistry, School of Dentistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece. jeny@dent.auth.gr
authors.forename: Eugenia
authors.initials: E
authors.lastname: Koliniotou-Koumpia
authors.forename: Serafim
authors.initials: S
authors.lastname: Papadimitriou
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Tziafas
mesh_terms: D000818:Animals; D017438:Bisphenol A-Glycidyl Methacrylate / Q000494:pharmacology; D001840:Dental Bonding; D003737:Dental Cavity Preparation / Q000379:methods; D003782:Dental Pulp / Q000187:drug effects* / Q000473:pathology; D003804:Dentin / Q000187:drug effects / Q000473:pathology; D017220:Dentin-Bonding Agents / Q000494:pharmacology*; D004285:Dogs; D000431:Ethanol / Q000494:pharmacology; D008297:Male; D008689:Methacrylates / Q000494:pharmacology; D009804:Odontoblasts / Q000187:drug effects / Q000473:pathology; D010710:Phosphates / Q000494:pharmacology; D011671:Pulpitis / Q000139:chemically induced / Q000473:pathology; D011897:Random Allocation; D019279:Resin Cements / Q000494:pharmacology; D013997:Time Factors
chemical_list: C438313:Clearfil SE Bond; D017220:Dentin-Bonding Agents; C469823:Etch&Prime 3.0; D008689:Methacrylates; D010710:Phosphates; C408584:Prompt L-Pop; D019279:Resin Cements; C115612:single bond; D000431:Ethanol; D017438:Bisphenol A-Glycidyl Methacrylate