Oxime and oxime ether derivatives of 1,4-benzothiazine related to oxiconazole.
The synthesis, in vitro antifungal activity, and molecular docking experiments of some oxime and oxime ether derivatives of azole 1,4-benzothiazine are reported herein, with the aim of evaluating the influence of a partially constrained scaffold that is structurally related to Oxiconazole and bearing the 1,4-benzothiazine moiety, on the inhibition of Candida albicans CYP51.
Milanese
Lara
L
Dipartimento di Chimica e Tecnologia del Farmaco, Via del Liceo, 1, Università degli Studi di Perugia, 06123 Perugia, Italy.
Giacchè
Nicola
N
Schiaffella
Fausto
F
Vecchiarelli
Anna
A
Macchiarulo
Antonio
A
Fringuelli
Renata
R
D000935:Antifungal Agents / Q000737:chemistry* / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D004987:Ethers; D007093:Imidazoles / Q000737:chemistry* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D010091:Oximes / Q000737:chemistry* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013843:Thiazines / Q000737:chemistry*
C446962:1,4-benzothiazine; D000935:Antifungal Agents; D004987:Ethers; D007093:Imidazoles; D010091:Oximes; D013843:Thiazines; C022155:oxiconazole