PPARgamma and GLUT-4 expression as developmental regulators/markers for preadipocyte differentiation into an adipocyte.
In this document, we have integrated knowledge about two major cellular markers found in cells of the adipocyte lineage (an adipogenic marker and a metabolic marker). This review provides information as to how differentiation of a cell (such as an adipofibroblast, fibroblast or preadipocyte) to become a viable (and new) adipocyte is under different regulation than that experienced by an immature adipocyte that is just beginning to accumulate lipid. The differentiation, prior to lipid-filling, involves PPARgamma. Subsequently, lipid-filling of the adipocyte relies on a late subset of genes and, depending on depot specificity, involves GLUT-4 or any number of other metabolic markers.
Fernyhough
M E
ME
Department of Animal Sciences, Washington State University, PO Box 646310, Pullman, WA 99164, United States.
Okine
E
E
Hausman
G
G
Vierck
J L
JL
Dodson
M V
MV
D017667:Adipocytes / Q000166:cytology*; D000818:Animals; D022762:CCAAT-Enhancer-Binding Proteins / Q000502:physiology; D002454:Cell Differentiation / Q000502:physiology*; D016207:Cytokines / Q000502:physiology; D005227:Fatty Acids / Q000502:physiology; D005786:Gene Expression Regulation; D051275:Glucose Transporter Type 4 / Q000235:genetics* / Q000502:physiology*; D006801:Humans; D006854:Hydrocortisone / Q000502:physiology; D007328:Insulin / Q000502:physiology; D047495:PPAR gamma / Q000235:genetics* / Q000502:physiology*; D013234:Stem Cells / Q000166:cytology
D022762:CCAAT-Enhancer-Binding Proteins; D016207:Cytokines; D005227:Fatty Acids; D051275:Glucose Transporter Type 4; D007328:Insulin; D047495:PPAR gamma; D006854:Hydrocortisone