title: Photoinduced diastereoselective addition of perfluoroalkyl iodides to acrylic acid derivatives for the synthesis of fluorinated amino acids.
abstract: Photoinduced diastereoselective addition of perfluoroalkyl iodides in the presence of an aqueous solution of Na2S2O3 was an excellent method for iodoperfluoroalkylation of acrylic acid derivatives bearing a chiral auxiliary, with moderate to good stereoselectivities and with no detectable side products. The iodoperfluoroalkylation of N-acyloylcamphorsultam provided a convenient route for preparing chiral fluorine-containing amino acids.
authors.affiliation: Department of Chemistry, Faculty of Science, Ochanomizu University, Otsuka, Bunkyo-ku, Tokyo 112-8610, Japan. yajima.tomoko@ocha.ac.jp
authors.forename: Tomoko
authors.initials: T
authors.lastname: Yajima
authors.forename: Hajime
authors.initials: H
authors.lastname: Nagano
mesh_terms: D000179:Acrylates / Q000737:chemistry*; D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry*; D005461:Fluorine / Q000737:chemistry*; D007454:Iodides / Q000737:chemistry*; D008027:Light; D015394:Molecular Structure; D010777:Photochemistry
chemical_list: D000179:Acrylates; D000596:Amino Acids; D007454:Iodides; D005461:Fluorine; C036658:acrylic acid