Status epilepticus associated with initiation of theophylline in an elderly patient with diabetic ketoacidosis.
An 80-year-old man with a history of Type 2 diabetes mellitus was hospitalized due to generalized convulsive status epilepticus. Initially, hyperglycemia and ketoacidosis were diagnosed, but his seizures were refractory to the medical treatment. Additionally, a high level of serum theophylline (29.1 mg/mL) was detected. Following detoxification of theophylline by oral activated charcoal, the patient regained consciousness and was free from seizures without antiepileptic drug treatment. Brain magnetic resonance imaging revealed subacute subdural hematomas at the bilateral occipital hemispheres. This case suggests that theophylline toxicity may be a predisposing factor for seizures in patients with a history of traumatic brain injury in spite of the presence of diabetic ketoacidosis that may have an anticonvulsant action.
Chou
Chung-Hsing
CH
Department of Neurology, Tri-Service General Hospital, National Defense Medical Center, Taiwan. plshi2003@yahoo.com.tw
Lin
Jiann-Chyun
JC
Peng
Giia-Sheun
GS
D000369:Aged, 80 and over; D001993:Bronchodilator Agents / Q000009:adverse effects* / Q000627:therapeutic use; D003924:Diabetes Mellitus, Type 2 / Q000150:complications; D016883:Diabetic Ketoacidosis / Q000150:complications*; D006408:Hematoma, Subdural / Q000150:complications; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D029424:Pulmonary Disease, Chronic Obstructive / Q000188:drug therapy; D013226:Status Epilepticus / Q000139:chemically induced*; D013806:Theophylline / Q000009:adverse effects* / Q000627:therapeutic use
D001993:Bronchodilator Agents; D013806:Theophylline