Inhibitors of the heat shock response: biology and pharmacology.
A number of human diseases can be linked to aberrations in protein folding which cause an imbalance in protein homeostasis. Molecular chaperones, including heat shock proteins, act to assist protein folding, stability and activity in the cell. Attention has begun to focus on modulating the expression and/or activity of this group of proteins for the treatment of a wide variety of human diseases. This review will describe the progress made to date in developing pharmacological modulators of the heat shock response, including both agents which affect the entire heat shock response and those that specifically target the HSP70 and HSP90 chaperone families.
Powers
Marissa V
MV
Cancer Research UK Centre for Cancer Therapeutics, The Institute of Cancer Research, Haddow Laboratories, 15 Cotswold Road, Sutton Surrey SM2 5NG, UK.
Workman
Paul
P
D004268:DNA-Binding Proteins; D015195:Drug Design; D050884:HSP72 Heat-Shock Proteins / Q000187:drug effects*; D018841:HSP90 Heat-Shock Proteins / Q000187:drug effects*; D000076249:Heat Shock Transcription Factors; D018869:Heat-Shock Response / Q000187:drug effects*; D006801:Humans; D018832:Molecular Chaperones / Q000187:drug effects*; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D010600:Pharmacology; D014157:Transcription Factors
D004268:DNA-Binding Proteins; D050884:HSP72 Heat-Shock Proteins; D018841:HSP90 Heat-Shock Proteins; D000076249:Heat Shock Transcription Factors; D018832:Molecular Chaperones; D004364:Pharmaceutical Preparations; D014157:Transcription Factors