A Ramberg-Bäcklund route to the stilbenoid anti-cancer agents combretastatin A-4 and DMU-212.
A concise route to combretastatin A-4, a potent inhibitor of tubulin polymerisation, using a Ramberg-Bäcklund reaction to form the key (Z)-stilbene unit has been developed; this Ramberg-Bäcklund approach has also been extended to prepare the (E)-stilbene DMU-212, which also possesses interesting growth inhibitory properties.
Robinson
James E
JE
Department of Chemistry, University of York, Heslington, York, UKYO10 5DD.
Taylor
Richard J K
RJ
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013267:Stilbenes / Q000138:chemical synthesis* / Q000737:chemistry; D013450:Sulfones / Q000737:chemistry
C482492:3,4,5,4'-tetramethoxystilbene; D000970:Antineoplastic Agents; D013267:Stilbenes; D013450:Sulfones; C058728:fosbretabulin