Fasting triglyceride is a major determinant of postprandial triglyceride response in postmenopausal women.
OBJECTIVE
The purpose of the study was to examine the relative influences of fasting lipids, insulin resistance, and waist circumference (WC) on postprandial lipemia in postmenopausal women.


METHODS
Forty-nine naturally postmenopausal women were recruited for the study. Each woman underwent a 75-g oral glucose tolerance test to measure insulin resistance and a 1,000-kcal high-fat mixed meal test for postprandial triglyceride (TG) response.


RESULTS
The participants were divided into three groups by tertiles of incremental TG response in the mixed meal test. The three groups were comparable in weight, WC, and fasting high-density lipoprotein cholesterol (HDL-C) levels. There were significant differences in fasting TG and non-HDL-C concentrations among the three groups. The women in the high-tertile group were more insulin resistant than those in the low-tertile group, indicated by higher homeostasis model assessment for insulin resistance (HOMA-IR) values. The postprandial TG response was significantly correlated with Log(fasting TG), fasting non-HDL-C and Log(HOMA-IR), but not with WC, in univariate regression analyses. Log(fasting TG) was the only variable that remained significantly related to incremental TG response when all the above were entered into multiple regression models. Subsequently, we found that Log(HOMA-IR) and fasting non-HDL-C independently predicted the variance of Log(fasting TG) in stepwise multiple regression.


CONCLUSIONS
Our data demonstrated that the fasting TG level is a major determinant of postprandial TG response in postmenopausal women. Insulin resistance and non-HDL-C may contribute independently to the fasting TG level. The influences of WC on postprandial lipemia seemed to be insignificant.
Hwu
Chii-Min
CM
Section of General Medicine, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan. chhwu@vghtpe.gov.tw
Lin
Ming-Wei
MW
Liou
Teh-Ling
TL
Hsiao
Li-Chuan
LC
Liang
Kai-Wen
KW
Tsai
Ting-Ting
TT
Ho
Low-Tone
LT
D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D008055:Lipids / Q000097:blood; D008875:Middle Aged; D017698:Postmenopause / Q000378:metabolism*; D019518:Postprandial Period; D012016:Reference Values; D012044:Regression Analysis; D014280:Triglycerides / Q000097:blood*; D049629:Waist-Hip Ratio
D001786:Blood Glucose; D008055:Lipids; D014280:Triglycerides