Effects of tension-compression nonlinearity on solute transport in charged hydrated fibrous tissues under dynamic unconfined compression.
Cartilage is a charged hydrated fibrous tissue exhibiting a high degree of tension-compression nonlinearity (i.e., tissue anisotropy). The effect of tension-compression nonlinearity on solute transport has not been investigated in cartilaginous tissue under dynamic loading conditions. In this study, a new model was developed based on the mechano-electrochemical mixture model [Yao and Gu, 2007, J. Biomech. Model Mechanobiol., 6, pp. 63-72, Lai et al., 1991, J. Biomech. Eng., 113, pp. 245-258], and conewise linear elasticity model [Soltz and Ateshian, 2000, J. Biomech. Eng., 122, pp. 576-586; Curnier et al., 1995, J. Elasticity, 37, pp. 1-38]. The solute desorption in cartilage under unconfined dynamic compression was investigated numerically using this new model. Analyses and results demonstrated that a high degree of tissue tension-compression nonlinearity could enhance the transport of large solutes considerably in the cartilage sample under dynamic unconfined compression, whereas it had little effect on the transport of small solutes (at 5% dynamic strain level). The loading-induced convection is an important mechanism for enhancing the transport of large solutes in the cartilage sample with tension-compression nonlinearity. The dynamic compression also promoted diffusion of large solutes in both tissues with and without tension-compression nonlinearity. These findings provide a new insight into the mechanisms of solute transport in hydrated, fibrous soft tissues.
Huang
Chun-Yuh
CY
Department of Pediatric Dentistry, Nova Southeastern University, Ft. Lauderdale, FL, USA.
Gu
Wei Yong
WY
D001693:Biological Transport, Active / Q000502:physiology; D002358:Cartilage, Articular / Q000502:physiology*; D019245:Compressive Strength; D003198:Computer Simulation; D004058:Diffusion; D040542:Mechanotransduction, Cellular / Q000502:physiology*; D008954:Models, Biological; D016062:Porosity; D012996:Solutions; D013314:Stress, Mechanical; D013718:Tensile Strength; D014867:Water / Q000378:metabolism; D016474:Weight-Bearing / Q000502:physiology*
D012996:Solutions; D014867:Water