title: Long-term results of trabeculectomy with mitomycin C applied under the scleral flap.
abstract: OBJECTIVE
  The objective of this study was to look at the long-term safety, and the effectiveness on intraocular pressure, of trabeculectomy and mitomycin C (MMC) applied under the scleral flap.
  
  
  METHODS
  All patients undergoing trabeculectomy and MMC application during the period June 1992-August 1995 were included. Data on 30 eyes of 25 patients were reviewed. We looked at sociodemographic variables, intraocular pressure (IOP) control, visual acuities and bleb morphology. Bleb-related and other complications were also noted. Statistical analysis was performed with Student's paired t-test, and Kaplan-Meier life table analysis was utilised for IOP control.
  
  
  RESULTS
  The mean age of patients (12 male and 13 female) was 56 years (range 7-79 years), with a mean follow-up period of 8.7 years (range 5-11 years). There was one eye with blebitis/endophthalmitis at 4 years, and one eye developed hypotonous maculopathy. Ten eyes were noted to have poor bleb morphology due to long-standing fibrosis, and the majority of these underwent further surgical intervention with 5-fluorouracil (5FU) needling. The IOP control showed good results, with mean IOP falling from a preoperative level of 24.8-15.2 mmHg at the last visit, with good probability of maintenance in the longer term. The main reason for reduced vision was pre-existing co-morbidity and development of lenticular opacities.
  
  
  CONCLUSIONS
  In the series with the longest follow-up period our study showed that trabeculectomy augmented with MMC under the scleral flap in these difficult cases can achieve good long-term IOP control and is associated with minimal long-term complications.
authors.affiliation: Birmingham and Midland Eye Centre, Dudley Road, Birmingham, UK.
authors.forename: Ioannis
authors.initials: I
authors.lastname: Kyprianou
authors.forename: Maged
authors.initials: M
authors.lastname: Nessim
authors.forename: Vinod
authors.initials: V
authors.lastname: Kumar
authors.forename: Eammon
authors.initials: E
authors.lastname: O'Neill
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000477:Alkylating Agents / Q000008:administration & dosage*; D002648:Child; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D005901:Glaucoma / Q000188:drug therapy* / Q000601:surgery*; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage*; D012590:Sclera / Q000187:drug effects*; D013524:Surgical Flaps; D014130:Trabeculectomy / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D000477:Alkylating Agents; D016685:Mitomycin