title: Reaction time: An alternative method for assessing the effects of multiple sclerosis on information processing speed.
abstract: The ability of a newly developed measure of information processing to detect deficits in cognitive functioning associated with multiple sclerosis (MS) was investigated. The Computerized Tests of Information Processing (CTIP; Tombaugh, T., & Rees, L. (1999). Computerized Tests of Information Processing (CTIP). Unpublished test. Ottawa, Ontario, Canada: Carleton University) was administered to 60 clinically definite MS patients and 60 healthy controls. MS patients responded significantly slower than controls on the reaction time tests composing the CTIP. Moreover, as the CTIP tests became more difficult (i.e. as processing demands increased), the difference between the performances of the two groups progressively increased. These results suggest the CTIP is sensitive to the cognitive deficits observed in MS and that this measure has the potential to serve as a viable alternative to traditional measures of information processing speed currently in use with MS patients.
authors.affiliation: Psychology Department, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario, Canada.
authors.forename: Lindsay I
authors.initials: LI
authors.lastname: Reicker
authors.forename: Tom N
authors.initials: TN
authors.lastname: Tombaugh
authors.forename: Lisa
authors.initials: L
authors.lastname: Walker
authors.forename: Mark S
authors.initials: MS
authors.lastname: Freedman
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001288:Attention; D002755:Choice Behavior; D004193:Discrimination Learning; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020528:Multiple Sclerosis, Chronic Progressive / Q000175:diagnosis / Q000523:psychology*; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000175:diagnosis / Q000523:psychology*; D010364:Pattern Recognition, Visual; D011340:Problem Solving; D011597:Psychomotor Performance; D011930:Reaction Time; D011932:Reading; D012016:Reference Values; D012660:Semantics