Novel tRNA aminoacylation mechanisms.
In nature, ribosomally synthesized proteins can contain at least 22 different amino acids: the 20 common amino acids as well as selenocysteine and pyrrolysine. Each of these amino acids is inserted into proteins codon-specifically via an aminoacyl-transfer RNA (aa-tRNA). In most cases, these aa-tRNAs are biosynthesized directly by a set of highly specific and accurate aminoacyl-tRNA synthetases (aaRSs). However, in some cases aaRSs with relaxed or novel substrate specificities cooperate with other enzymes to generate specific canonical and non-canonical aminoacyl-tRNAs.
Cathopoulis
Terry
T
Department of Chemistry, Johns Hopkins University, 3400 N. Charles St., Baltimore, MD 21218, USA.
Chuawong
Pitak
P
Hendrickson
Tamara L
TL
D000604:Amino Acyl-tRNA Synthetases / Q000378:metabolism; D001226:Aspartate-tRNA Ligase / Q000378:metabolism; D001419:Bacteria / Q000201:enzymology; D012346:RNA, Transfer, Amino Acyl / Q000096:biosynthesis / Q000737:chemistry / Q000378:metabolism; D012348:RNA, Transfer, Asn / Q000096:biosynthesis / Q000737:chemistry; D012350:RNA, Transfer, Cys / Q000096:biosynthesis / Q000737:chemistry; D012351:RNA, Transfer, Gln / Q000096:biosynthesis / Q000737:chemistry; D046249:Transfer RNA Aminoacylation
D012346:RNA, Transfer, Amino Acyl; D012348:RNA, Transfer, Asn; D012350:RNA, Transfer, Cys; D012351:RNA, Transfer, Gln; C112705:selenocysteinyl-tRNA; D000604:Amino Acyl-tRNA Synthetases; D001226:Aspartate-tRNA Ligase; C019975:cysteinyl-tRNA synthetase; C020659:glutaminyl-tRNA synthetase; C029194:asparaginyl-tRNA synthetase