Fine needle aspiration cytolog of perineal alveolar rhabdomyosarcoma: cytohistopathologic and immunocytochemical correlations.
OBJECTIVE
To describe the cytopathologic findings in a case of alveolar rhabdomyosarcoma (ARMS) of the perineum in a 13-year-old girl and to compare the cytopathologic findings with the histopathologic and immunohistochemical features observed on the corresponding fragments obtained from core biopsy of the mass.


METHODS
The cytopathologic findings observed in fine needle aspiration biopsy of a vulvar mass were analyzed with reference to their predictive diagnostic value in pathologic evaluation of the lesion.


RESULTS
Following a prospective cytopathologic diagnosis of ARMS, a cutting needle core biopsy was performed. Histopathologic and immunohistochemical study of the tissue fragments confirmed the cytopathologic diagnosis.


CONCLUSIONS
Careful cytopathologic evaluation of optimal cell samples from ARMS may elicit a correct diagnosis provided that immunocytochemical staining for markers of myogenic differentiation is performed in a pretherapeutic phase.
Fulciniti
Franco
F
Department of Pathology, National Cancer Institute of Naples G. Pascale Foundation, Naples, Italy. franco.fulciniti@gmail.com
Botti
Gerardo
G
De Chiara
Annarosaria
A
Parlato
Vincenzo
V
Russo
Serena
S
Vosa
Laura
L
Nappi
M Michela
MM
D000293:Adolescent; D044963:Biopsy, Fine-Needle; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D010502:Perineum / Q000000981:diagnostic imaging / Q000473:pathology*; D011237:Predictive Value of Tests; D018232:Rhabdomyosarcoma, Alveolar / Q000000981:diagnostic imaging / Q000473:pathology*; D014463:Ultrasonography; D014844:Vulva / Q000000981:diagnostic imaging / Q000473:pathology*; D014846:Vulvar Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*