title: Molecular design, chemical synthesis, and biological evaluation of '4-1' pentacyclic aryl/heteroaryl-imidazonaphthalimides.
abstract: A novel series of '4-1' pentacyclic naphthalimides, where the chromophore consists of a naphthalimide moiety, fused to an imidazole ring containing an unfused aryl or heteroaryl ring, were synthesized and evaluated for in vitro antitumor activity. In general, the new derivatives showed an improved cytotoxic activity over amonafide. DNA binding experiments supported that this class of compounds behaves as effective DNA-intercalating agents.
authors.affiliation: State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Li
authors.forename: Jingnan
authors.initials: J
authors.lastname: Cui
authors.forename: Lianying
authors.initials: L
authors.lastname: Guo
authors.forename: Xuhong
authors.initials: X
authors.lastname: Qian
authors.forename: Weimin
authors.initials: W
authors.lastname: Ren
authors.forename: Kewei
authors.initials: K
authors.lastname: Wang
authors.forename: Fengyu
authors.initials: F
authors.lastname: Liu
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004247:DNA / Q000737:chemistry; D006801:Humans; D051379:Mice; D015394:Molecular Structure; D053644:Naphthalimides / Q000737:chemistry* / Q000494:pharmacology*; D013056:Spectrophotometry, Ultraviolet; D013329:Structure-Activity Relationship; D044366:Transition Temperature
chemical_list: D000970:Antineoplastic Agents; D053644:Naphthalimides; D004247:DNA