Natural feruloyl monoglyceride macrocycles as protecting factors against free-radical damage of lipidic membranes.
Nine novel natural feruloyl monoglyceride (MGs) macrocycles have been isolated from the leaves of Carex distachya, an herbaceous plant growing in the Mediterranean maquis. All the structures have been elucidated on the basis of their spectroscopic features, especially two-dimensional NMR (DQ-COSY, TOCSY, NOESY, ROESY, HSQC, HMBC, HSQC-TOCSY) and ESI-MS. All the compounds have been assayed as protecting factors against the radical damage of the lipids by using different antioxidant tests.
D'Abrosca
Brigida
B
Dipartimento di Scienze della Vita - Seconda Università degli Studi di Napoli - via Vivaldi 43, 81100 Caserta, Italy.
Fiorentino
Antonio
A
Pacifico
Severina
S
Cefarelli
Giuseppe
G
Uzzo
Piera
P
Letizia
Marianna
M
Monaco
Pietro
P
D000818:Animals; D005609:Free Radicals; D015227:Lipid Peroxidation; D047028:Macrocyclic Compounds / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008563:Membrane Lipids / Q000378:metabolism*; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism; D050178:Monoglycerides / Q000494:pharmacology*; D051381:Rats; D021241:Spectrometry, Mass, Electrospray Ionization; D017392:Thiobarbituric Acid Reactive Substances
D005609:Free Radicals; D047028:Macrocyclic Compounds; D008563:Membrane Lipids; D050178:Monoglycerides; D017392:Thiobarbituric Acid Reactive Substances