title: [Semantic dementia].
abstract: Semantic dementia (SD) is characterized by an assymetric atrophy of the temporal lobes and, clinically, by an impairment of the semantic memory associated to psychobehavioral symptoms. The concept of SD was defined in 1989 and still remains controversial. Some authors consider DS as a specific entity, others as part of the frontotemporal dementia (FTD) or a variant of the progressive aphasia syndrome. Many arguments tend to include SD in the FTD. However, SD presents a high interest for the comprehension of the organization of semantic memory in man, and is often associated with specific histopathologic lesions (ubiquitine positive and tau negative). Therefore SD should be considered as a clinical specific entity.
authors.affiliation: Centre mémoire de ressource et de recherche, Service de neurologie, CHU Pontchaillou. Rennes. serge.belliard@chu-rennes.fr
authors.forename: Serge
authors.initials: S
authors.lastname: Belliard
authors.forename: Laetitia
authors.initials: L
authors.lastname: Bon
authors.forename: Sandrine
authors.initials: S
authors.lastname: LeMoal
authors.forename: Pierre Yves
authors.initials: PY
authors.lastname: Jonin
authors.forename: Martine
authors.initials: M
authors.lastname: Vercelletto
authors.forename: Benoit
authors.initials: B
authors.lastname: LeBail
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis; D003704:Dementia / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology*; D003937:Diagnosis, Differential; D005625:Frontal Lobe / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D008569:Memory Disorders / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology; D013702:Temporal Lobe / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology; D015899:Tomography, Emission-Computed, Single-Photon; D016875:tau Proteins / Q000378:metabolism
chemical_list: D016875:tau Proteins