Macroautophagy: protector in the diabetes drama?
Macroautophagy ("autophagy") is regulated by the same insulin-amino acid-mTOR signaling pathway that controls protein synthesis. Although the literature does not so far include any direct studies confirming this, we expect autophagy to increase during insulin resistance. We discuss the possibility that this may be a useful mechanism for eliminating damaged mitochondria and other cell structures to prevent cell death.
Meijer
Alfred J
AJ
Department of Medical Biochemistry, Academic Medical Center, Amsterdam, The Netherlands. a.j.meijer@amc.uva.nl
Codogno
Patrice
P
D000375:Aging / Q000378:metabolism / Q000473:pathology; D000818:Animals; D001343:Autophagy / Q000502:physiology*; D003920:Diabetes Mellitus / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D006801:Humans; D007333:Insulin Resistance; D051379:Mice; D008928:Mitochondria / Q000378:metabolism / Q000473:pathology; D008954:Models, Biological; D011494:Protein Kinases / Q000378:metabolism; D015398:Signal Transduction; D058570:TOR Serine-Threonine Kinases
D011494:Protein Kinases; C546842:MTOR protein, human; C546843:mTOR protein, mouse; D058570:TOR Serine-Threonine Kinases