title: Synthesis and evaluation of pyrazolo[3,4-b]pyridine CDK1 inhibitors as anti-tumor agents.
abstract: A series of 3,5-disubstituted pyrazolo[3,4-b]pyridine cyclin-dependent kinase (CDK) inhibitors was synthesized. These compounds showed potent and selective CDK inhibitory activities and inhibited in vitro cellular proliferation in cultured human tumor cells. Selected compounds were evaluated in an in vivo tumor xenograft model. The synthesis and biological evaluation of these pyrazolo[3,4-b]pyridines and related compounds are reported.
authors.affiliation: Johnson & Johnson Pharmaceutical Research & Development L.L.C., 1000 Route 202, PO Box 300, Raritan, NJ 08869, USA. Ronghui.Lin@yahoo.com
authors.forename: Ronghui
authors.initials: R
authors.lastname: Lin
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Connolly
authors.forename: Yanhua
authors.initials: Y
authors.lastname: Lu
authors.forename: George
authors.initials: G
authors.lastname: Chiu
authors.forename: Shengjian
authors.initials: S
authors.lastname: Li
authors.forename: Yang
authors.initials: Y
authors.lastname: Yu
authors.forename: Shenlin
authors.initials: S
authors.lastname: Huang
authors.forename: Xun
authors.initials: X
authors.lastname: Li
authors.forename: Stuart L
authors.initials: SL
authors.lastname: Emanuel
authors.forename: Steven A
authors.initials: SA
authors.lastname: Middleton
authors.forename: Robert H
authors.initials: RH
authors.lastname: Gruninger
authors.forename: Mary
authors.initials: M
authors.lastname: Adams
authors.forename: Angel R
authors.initials: AR
authors.lastname: Fuentes-Pesquera
authors.forename: Lee M
authors.initials: LM
authors.lastname: Greenberger
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D016203:CDC2 Protein Kinase / Q000037:antagonists & inhibitors*; D002478:Cells, Cultured; D006801:Humans; D047428:Protein Kinase Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D047428:Protein Kinase Inhibitors; D011720:Pyrazoles; D011725:Pyridines; C447480:pyrazolo(3,4-b)pyridine; D016203:CDC2 Protein Kinase