title: Platelet glycoprotein IIb HPA-3 polymorphism and acute coronary syndromes.
abstract: BACKGROUND
  There is considerable research interest about the platelet GPIIb/IIIa receptor polymorphisms in CAD.
  
  
  METHODS
  We investigated differences in the frequency of the polymorphism in the GPIIb subunit of the receptor HPA-3 (a and b allele) between patients with more extensive coronary thrombosis such as patients with ST segment elevation (STEMI) and those with less extensive coronary thrombosis such as those with non-ST elevation myocardial infarction (NSTEMI), unstable angina (UA) or chronic CAD. We studied 118 CAD patients, of which 38 suffered from STEMI, 62 from NSTEMI or UA and 18 from chronic CAD and 15 healthy individuals. Patients were followed-up for 21+/-6 months for occurrence of death, myocardial infarction and revascularization.
  
  
  RESULTS
  Seventeen out of 38 (45%) patients with STEMI were homozygous for the HPA-3 b allele compared to 6 out 62 (10%) with NSTEMI-UA , 4 out of 18 (22%) with chronic CAD and 2 out of 15 (13%) healthy controls (chi(2)=16,4, p=0.03.) Homozygous patients for the HPA-3b exhibited a 5-fold higher risk for STEMI compared to heterozygous patients for HPA-3b or homozygous for HPA-3a allele (OR: 5.90, 95% CI: 2.15-16.54, p=0.01) after adjustment for age, sex and risk factors. The HPA-3 genotypes were not related with cardiovascular events during follow-up.
  
  
  CONCLUSIONS
  Among patients with an acute coronary syndrome those being HPA-3b homozygous have a tendency to develop ST segment elevation myocardial infarction instead of non-ST segment elevation infarction or unstable angina. There is no association between the HPA-3 genotypes and future cardiovascular events.
authors.affiliation: Department of Cardiology, Attikon University Hospital, Athens University, Greece. lekakis@tellas.gr
authors.forename: John
authors.initials: J
authors.lastname: Lekakis
authors.forename: Sofia
authors.initials: S
authors.lastname: Bisti
authors.forename: Elias
authors.initials: E
authors.lastname: Tsougos
authors.forename: Athanasios
authors.initials: A
authors.lastname: Papathanassiou
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Dagres
authors.forename: Ignatios
authors.initials: I
authors.lastname: Ikonomidis
authors.forename: Ekaterini
authors.initials: E
authors.lastname: Soteriadou
authors.forename: Alexandros D
authors.initials: AD
authors.lastname: Tselepis
authors.forename: John
authors.initials: J
authors.lastname: Goudevenos
authors.forename: Dimitris Th
authors.initials: DT
authors.lastname: Kremastinos
mesh_terms: D054058:Acute Coronary Syndrome / Q000235:genetics* / Q000401:mortality; D000368:Aged; D000483:Alleles; D000704:Analysis of Variance; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005260:Female; D005838:Genotype; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012307:Risk Factors; D012737:Sex Factors
chemical_list: D019039:Platelet Glycoprotein GPIIb-IIIa Complex