title: Genetics of restless legs syndrome (RLS): State-of-the-art and future directions.
abstract: Several studies demonstrated that 60% of restless legs syndrome (RLS) patients have a positive family history and it has been suggested that RLS is a highly hereditary trait. To date, several loci have been mapped but no gene has been identified yet. Phenocopies and possible nonpenetrants made it difficult to detect a common segregating haplotype within the families. Defining the exact candidate region is hampered by possible intrafamilial, allelic, and nonallelic heterogeneity. One important prerequisite for future successful genetic studies in RLS is the availability of large and thoroughly phenotyped patients and family samples for linkage as well as association studies.
authors.affiliation: Institute of Human Genetics, GSF-National Research Center for Environment and Health, Munich, Germany. julianewinkelmann@t-online.de
authors.forename: Juliane
authors.initials: J
authors.lastname: Winkelmann
authors.forename: Oli
authors.initials: O
authors.lastname: Polo
authors.forename: Federica
authors.initials: F
authors.lastname: Provini
authors.forename: Sonja
authors.initials: S
authors.lastname: Nevsimalova
authors.forename: David
authors.initials: D
authors.lastname: Kemlink
authors.forename: Karel
authors.initials: K
authors.lastname: Sonka
authors.forename: Birgit
authors.initials: B
authors.lastname: Högl
authors.forename: Werner
authors.initials: W
authors.lastname: Poewe
authors.forename: Karin
authors.initials: K
authors.lastname: Stiasny-Kolster
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Oertel
authors.forename: Al
authors.initials: A
authors.lastname: de Weerd
authors.forename: Luigi Ferini
authors.initials: LF
authors.lastname: Strambi
authors.forename: Marco
authors.initials: M
authors.lastname: Zucconi
authors.forename: Peter P
authors.initials: PP
authors.lastname: Pramstaller
authors.forename: Isabelle
authors.initials: I
authors.lastname: Arnulf
authors.forename: Claudia
authors.initials: C
authors.lastname: Trenkwalder
authors.forename: Christine
authors.initials: C
authors.lastname: Klein
authors.forename: Georgios M
authors.initials: GM
authors.lastname: Hadjigeorgiou
authors.forename: Svenja
authors.initials: S
authors.lastname: Happe
authors.forename: David
authors.initials: D
authors.lastname: Rye
authors.forename: Pasquale
authors.initials: P
authors.lastname: Montagna
mesh_terms: D008040:Genetic Linkage; D006801:Humans; D040582:Inheritance Patterns; D010641:Phenotype; D012148:Restless Legs Syndrome / Q000235:genetics*