title: Oral vaccination against bovine tuberculosis with Mycobacterium bovis BCG.
abstract: The use of a bacillus Calmette-Guerin (BCG)-based vaccine could represent a viable strategy for controlling bovine tuberculosis (TB), principally in those cases where a wildlife disease vector exists. This article focuses on recent progress in animal TB vaccinology, outlining that oral-route vaccination represents the most feasible means of distributing a vaccine to control disease in wildlife. Drawing on historical successes of previous wildlife vaccination programs, the article suggests how, and in what form, an oral-delivery BCG-based vaccine might become operational, considering the wide diversity of TB reservoir species and the inherent problems associated with field delivery of a live-attenuated microbial vaccine.
authors.affiliation: Immune Solutions, University of Otago, PO Box 56, Dunedin, New Zealand. frank.cross@stonebow.otago.ac.nz
authors.forename: Martin L
authors.initials: ML
authors.lastname: Cross
authors.forename: Frank
authors.initials: F
authors.lastname: Aldwell
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000835:Animals, Wild / Q000276:immunology*; D001500:BCG Vaccine / Q000008:administration & dosage* / Q000276:immunology*; D002417:Cattle; D014380:Tuberculosis, Bovine / Q000517:prevention & control*; D014611:Vaccination / Q000379:methods / Q000662:veterinary*
chemical_list: D001500:BCG Vaccine