Analytical methodologies for the determination of omeprazole: an overview.
Omeprazole, a gastric acid pump inhibitor, dose-dependently controls gastric acid secretion; the drug has greater antisecretory activity than histamine H(2)-receptor antagonists. Omeprazole has been determined in formulations and biological fluids by a variety of methods such as spectrophotometry, high-performance liquid chromatography with ultraviolet detection and liquid chromatography coupled with tandem mass spectrometry. The overview includes the most relevant analytical methodologies used in its determination since the origin still today.
Espinosa Bosch
M
M
Department of Pharmacy, General Hospital, University Hospital Virgen del Rocío, Manuel Siurot s/n, 41013 Seville, Spain.
Ruiz Sánchez
A J
AJ
Sánchez Rojas
F
F
Bosch Ojeda
C
C
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D025924:Chromatography, Supercritical Fluid; D002855:Chromatography, Thin Layer; D004563:Electrochemistry; D019075:Electrophoresis, Capillary; D006801:Humans; D013058:Mass Spectrometry; D009853:Omeprazole / Q000032:analysis*; D013053:Spectrophotometry; D013056:Spectrophotometry, Ultraviolet
D009853:Omeprazole