Adenosine phosphonate inhibitors of lipid II: alanyl tRNA ligase MurM from Streptococcus pneumoniae.
Adenosine and 2'-deoxyadenosine phosphonate transition state analogues act as the first inhibitors for the MurMN/FemABX family of tRNA-dependent ligases implicated in high-level penicillin resistance in gram-positive bacteria.
Cressina
Elena
E
Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK.
Lloyd
Adrian J
AJ
De Pascale
Gianfranco
G
Roper
David I
DI
Dowson
Christopher G
CG
Bugg
Timothy D H
TD
D000227:Adenine Nucleotides / Q000737:chemistry* / Q000494:pharmacology*; D001426:Bacterial Proteins; D015394:Molecular Structure; D010453:Peptide Synthases; D013296:Streptococcus pneumoniae / Q000187:drug effects / Q000201:enzymology; D014538:Uridine Diphosphate N-Acetylmuramic Acid / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors
D000227:Adenine Nucleotides; D001426:Bacterial Proteins; D014538:Uridine Diphosphate N-Acetylmuramic Acid; C069249:muramyl-NAc-(pentapeptide)pyrophosphoryl-undecaprenol; C408066:MurM protein, Streptococcus pneumoniae; D010453:Peptide Synthases