Changes in the plasma testosterone level and testicular superoxide dismutase activity of 5 azoospermic beagles after GnRH analogue injections.
The peripheral blood plasma testosterone (T) levels and superoxide dismutase (SOD) activity were measured in 5 azoospermic (AZ-) beagles. The mean values in the AZ-dogs were significantly lower than in 7 control beagles (P<0.001). Subcutaneous injections of 1 mug/kg GnRH analogue three times weekly in the AZ-dogs induced significant increases in mean T level and SOD activity (P<0.05) and improvement in spermatogenesis. Thus, spermatogenic function in the dog appears to be maintained by T and normal SOD activity in the testis.
Kawakami
Eiichi
E
Department of Reproduction, Nippon Veterinary and Life Science University, Musashino-shi, Tokyo, Japan.
Kuroda
Daiki
D
Hori
Tatsuya
T
Tsutsui
Toshihiko
T
D000818:Animals; D053713:Azoospermia / Q000188:drug therapy / Q000662:veterinary*; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D007987:Gonadotropin-Releasing Hormone / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D013053:Spectrophotometry / Q000662:veterinary; D013091:Spermatogenesis / Q000187:drug effects*; D013482:Superoxide Dismutase / Q000032:analysis*; D013737:Testis / Q000201:enzymology*; D013739:Testosterone / Q000097:blood*
D007987:Gonadotropin-Releasing Hormone; D013739:Testosterone; D013482:Superoxide Dismutase