title: 5(Z)-benzylidene-1,2-dihydro-9-hydroxy-10-methoxy-2,2,4-trimethyl-5H-1-aza-6-oxa-chrysenes as non-steroidal glucocorticoid receptor modulators.
abstract: A series of 5-benzylidene-1,2-dihydro-2,2,4-trimethyl-5H-1-aza-6-oxa-chrysenes was synthesized and profiled for their ability to act as selective glucocorticoid receptor modulators (SGRMs). The synthesis and structure-activity relationships for this series of compounds are presented.
authors.affiliation: Discovery Research, Ligand Pharmaceuticals, 10275 Science Center Drive, San Diego, CA 92121, USA.
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Ardecky
authors.forename: Andrew R
authors.initials: AR
authors.lastname: Hudson
authors.forename: Dean P
authors.initials: DP
authors.lastname: Phillips
authors.forename: John S
authors.initials: JS
authors.lastname: Tyhonas
authors.forename: Charlotte
authors.initials: C
authors.lastname: Deckhut
authors.forename: Thomas L
authors.initials: TL
authors.lastname: Lau
authors.forename: Yongkai
authors.initials: Y
authors.lastname: Li
authors.forename: Esther A
authors.initials: EA
authors.lastname: Martinborough
authors.forename: Steven L
authors.initials: SL
authors.lastname: Roach
authors.forename: Robert I
authors.initials: RI
authors.lastname: Higuchi
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Lopez
authors.forename: Keith B
authors.initials: KB
authors.lastname: Marschke
authors.forename: Jeffrey N
authors.initials: JN
authors.lastname: Miner
authors.forename: Donald S
authors.initials: DS
authors.lastname: Karanewsky
authors.forename: Andrés
authors.initials: A
authors.lastname: Negro-Vilar
authors.forename: Lin
authors.initials: L
authors.lastname: Zhi
mesh_terms: D002911:Chrysenes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D011965:Receptors, Glucocorticoid / Q000187:drug effects*; D013329:Structure-Activity Relationship
chemical_list: D002911:Chrysenes; D011965:Receptors, Glucocorticoid; C031180:chrysene