Matrix metalloproteinase-3 (stromelysin-1) in acute inflammatory tissue injury.
Mice lacking matrix metalloproteinase-3 (MMP-3; stromelysin-1) demonstrated significantly less injury than their normal counterparts following the formation of IgG-containing immune complexes in the alveolar wall or in the wall of the peritoneum. Likewise, mice lacking MMP-3 demonstrated less lung injury following intra-tracheal instillation of the chemotactic cytokine macrophage inhibitory protein-2 (MIP-2) than did mice with MMP-3. There was a relationship between tissue injury (evidenced histologically) and accumulation of anti-laminin 111 immunoreactive material in the bronchoalveolar lavage (BAL) or peritoneal lavage (PL) fluid. There was also a relationship between tissue injury and influx of neutrophils into the BAL or PL fluid. Taken together, these data demonstrate an important role for MMP-3 in acute inflammatory tissue injury.
Nerusu
Kamalakar C
KC
Department of Pathology, The University of Michigan Medical School, 1301 Catherine Road/Box 0602, Ann Arbor, MI 48109, USA.
Warner
Roscoe L
RL
Bhagavathula
Narasimharao
N
McClintock
Shannon D
SD
Johnson
Kent J
KJ
Varani
James
J
D000208:Acute Disease; D000818:Animals; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology / Q000276:immunology; D054426:Chemokine CXCL2; D018925:Chemokines / Q000502:physiology; D007074:Immunoglobulin G / Q000032:analysis*; D007249:Inflammation / Q000201:enzymology / Q000276:immunology / Q000473:pathology* / Q000517:prevention & control; D019278:Matrix Metalloproteinase 3 / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D018345:Mice, Knockout; D009504:Neutrophils / Q000473:pathology / Q000502:physiology
D054426:Chemokine CXCL2; D018925:Chemokines; C404915:Cxcl2 protein, mouse; D007074:Immunoglobulin G; D019278:Matrix Metalloproteinase 3