title: [Antiplatelets and anticoagulants in acute coronary syndromes: levels of evidence].
abstract: Management of acute coronary syndromes (ACS) has moved rapidly in parallel with our understanding of the pathophysiological basis of the disease. In the eighties, the demonstration of the pivotal role of coronary thrombosis in the etiology of a ACS led to administration of aspirin and unfractionated heparin. In recent years, new medical and invasive therapies have been developed: anti-platelets (thienopyridines and glycoprotein Ilb/IlIa inhibitors), antithrombins (low molecularweight heparins) and most recently, factor Xa inhibitors (pentasaccharides). As new treatments are rapidly added, clinicians are constantly challenged to incorporate new information and guidelines into their practices in a timely fashion.
authors.affiliation: Servicio de Hematología, Clínica Universitaria. Facultad de Medicina, Universidad de Navarra, España japaramo@unav.es
authors.forename: J A
authors.initials: JA
authors.lastname: Páramo
authors.forename: R
authors.initials: R
authors.lastname: García
authors.forename: P
authors.initials: P
authors.lastname: Rodríguez
authors.forename: E Ruiz
authors.initials: ER
authors.lastname: de Gaona
mesh_terms: D000208:Acute Disease; D000789:Angina, Unstable / Q000188:drug therapy*; D015906:Angioplasty, Balloon, Coronary; D000925:Anticoagulants / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D019468:Disease Management; D004569:Electroencephalography; D019317:Evidence-Based Medicine; D005343:Fibrinolytic Agents / Q000627:therapeutic use; D006801:Humans; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000628:therapy; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D012306:Risk
chemical_list: D000925:Anticoagulants; D005343:Fibrinolytic Agents; D010975:Platelet Aggregation Inhibitors