title: Parinaud's oculoglandular syndrome due to herpes simplex virus type 1.
abstract: OBJECTIVE
  To describe the clinical findings in a patient with Parinaud's oculoglandular syndrome as an uncommon manifestation of primary herpes simplex virus type 1 (HSV-1) infection.
  
  
  METHODS
  The clinical course, the laboratory findings, the therapy, and the outcome regarding a 14-year-old girl are described.
  
  
  RESULTS
  The culture and PCR detection of HSV-1 on conjunctiva and skin scrapings, along with seroconversion to HSV, confirmed the etiology. The oral and local acyclovir therapy led to a prompt improvement in the patient's symptoms.
  
  
  CONCLUSIONS
  The solitary ocular-glandular syndrome due to HSV-1 primary infection has never been reported before. Parinaud's oculoglandular syndrome is found in 5% of patients with cat-scratch disease and only on rare occasion associated with other conditions. Herpetic infection should be considered in the differential diagnosis of young patients with conjunctivitis, periorbital swelling, and painful preauricular and submandibular lymphadenopathy, combined with systemic symptoms of malaise and fever.
authors.affiliation: Department of Surgery, Ophthalmology Unit, University of Trieste and IRCCS, Burlo Garofolo, Trieste, Italy. parentin@burlo.trieste.it
authors.forename: Fulvio
authors.initials: F
authors.lastname: Parentin
authors.forename: Gianna Dal
authors.initials: GD
authors.lastname: Molin
authors.forename: Pierlanfranco
authors.initials: P
authors.lastname: D'Agaro
authors.forename: Marina
authors.initials: M
authors.lastname: Busetti
authors.forename: Cesare
authors.initials: C
authors.lastname: Campello
mesh_terms: D000212:Acyclovir / Q000627:therapeutic use; D000293:Adolescent; D000914:Antibodies, Viral / Q000032:analysis; D000998:Antiviral Agents / Q000627:therapeutic use; D004279:DNA, Viral / Q000032:analysis; D003937:Diagnosis, Differential; D015828:Eye Infections, Viral / Q000150:complications* / Q000188:drug therapy / Q000821:virology; D005260:Female; D005500:Follow-Up Studies; D006561:Herpes Simplex / Q000150:complications* / Q000188:drug therapy / Q000821:virology; D018259:Herpesvirus 1, Human / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D006801:Humans; D015835:Ocular Motility Disorders / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D016133:Polymerase Chain Reaction
chemical_list: D000914:Antibodies, Viral; D000998:Antiviral Agents; D004279:DNA, Viral; D000212:Acyclovir