title: HLA-G alleles and HLA-G 14 bp polymorphisms in a Brazilian population.
abstract: Brazilians represent one of the most heterogeneous populations in the world as the result of five centuries of interethnic crosses. We investigated the polymorphism of the HLA-G locus in a Brazilian urban sample. HLA-G alleles were determined by SBT analysis of exons 2-4 and 8 in 103 unrelated individuals. The genotyping analysis identified 11 different HLA-G alleles, including the recently described G*010110 allele, and four new variants in this population. These data indicate that this Brazilian population presents high HLA-G allelic polymorphism, suggesting increased levels of intrapopulational genetic diversity that may be because of the admixed nature of the sample. This is the first study regarding HLA-G genotyping that was performed at such refined resolution level in this heterogeneous population.
authors.affiliation: Division of Clinical Immunology, Department of Medicine, School of Medicine of Ribeirão Preto, University of São Paulo, Avenida Bandeirantes 3900, 14049-900 Ribeirão Preto, São Paulo, Brazil. castelli@usp.br
authors.forename: E C
authors.initials: EC
authors.lastname: Castelli
authors.forename: C T
authors.initials: CT
authors.lastname: Mendes-Junior
authors.forename: E A
authors.initials: EA
authors.lastname: Donadi
mesh_terms: D000483:Alleles; D001483:Base Sequence; D001938:Brazil; D005091:Exons; D005787:Gene Frequency; D018740:Genetic Heterogeneity; D014644:Genetic Variation; D005828:Genetics, Population; D005838:Genotype; D006680:HLA Antigens / Q000235:genetics*; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006801:Humans; D011110:Polymorphism, Genetic; D014505:Urban Population
chemical_list: D006680:HLA Antigens; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I