The distribution of I/D polymorphism in the ACE gene among Korean male elite athletes.
OBJECTIVE
The aim of this study was to examine the distribution of insertion/deletion (I/D) polymorphism in the ACE gene among Korean male elite athletes.


METHODS
Participants of the study were 139 Korean male elite athletes (15 basketball, 41 soccer, 31 baseball, 12 gymnastics, 7 volleyball, 8 long-distance running, 8 judo, and 17 ice hockey players). The control group consisted of 163 non-athletes. Polymerase chain reaction method was used to investigate I/D polymorphism of the ACE gene. Collected data were analyzed by SPSS 11.0 program.


RESULTS
The distribution of genotype and allele frequencies did not indicate the differences between the athletes and controls (P>0.05). However, the excess of II genotype and I allele was shown in long distance runners, although it was not statistically significant.


CONCLUSIONS
It may be necessary to perform further studies using a homogeneous cohort of subjects from single sporting discipline, because the probable role of I allele in athletic performance has been hard to be detected by heterogeneous groups of diverse sporting disciplines.
Oh
S D
SD
The Research Institute for Sports Science, Hanyang University, Seoul, Korea. sangduk@hanyang.ac.kr
D000328:Adult; D000704:Analysis of Variance; D016022:Case-Control Studies; D017353:Gene Deletion; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007723:Korea; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D013177:Sports / Q000502:physiology*
C488034:ACE protein, human; D007703:Peptidyl-Dipeptidase A