Live longer through PHAsting.
Dietary restriction provides considerable health benefits and may even increase life span in humans. Panowski et al. (2007) have now identified PHA-4/FoxA as an essential and specific component of DR-induced life-span extension in C. elegans.
Brenkman
Arjan B
AB
Laboratory of Physiological Chemistry, Division of Biomedical Genetics, University Medical Center Utrecht, Stratenum, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands. a.b.brenkman@umcutrecht.nl
Burgering
Boudewijn M T
BM
D000818:Animals; D017173:Caenorhabditis elegans / Q000254:growth & development / Q000378:metabolism*; D029742:Caenorhabditis elegans Proteins / Q000378:metabolism*; D031204:Caloric Restriction; D005215:Fasting / Q000502:physiology*; D008136:Longevity; D015534:Trans-Activators / Q000378:metabolism*
D029742:Caenorhabditis elegans Proteins; C113277:Pha-4 protein, C elegans; D015534:Trans-Activators