Distribution of radioactivity in bone and related structures following administration of [14C]dalbavancin to New Zealand white rabbits.
Penetration of dalbavancin into noninfected bone and joint tissues was assessed after an intravenous dose of 20 mg/kg (of body weight) [(14)C]dalbavancin given to rabbits. Drug-derived radioactivity, determined over 14 days by either liquid scintillation counting or autoradiography, remained above the MIC for common gram-positive pathogens that cause bone and joint infections.
Solon
Eric G
EG
Quest Pharmaceuticals Services, Newark, DE, USA.
Dowell
James A
JA
Lee
Jonghui
J
King
S Peter
SP
Damle
Bharat D
BD
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000494:pharmacology; D001345:Autoradiography; D001853:Bone Marrow / Q000378:metabolism; D001842:Bone and Bones / Q000378:metabolism*; D002250:Carbon Radioisotopes / Q000008:administration & dosage / Q000378:metabolism*; D003238:Connective Tissue / Q000378:metabolism; D006094:Gram-Positive Bacteria / Q000187:drug effects; D007596:Joints / Q000378:metabolism; D008297:Male; D008826:Microbial Sensitivity Tests; D011817:Rabbits; D017334:Teicoplanin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000494:pharmacology; D014018:Tissue Distribution
D000900:Anti-Bacterial Agents; D002250:Carbon Radioisotopes; D017334:Teicoplanin; C469289:dalbavancin