Lack of association between chronic periodontitis and the Toll-like receptor 4 gene polymorphisms in a Czech population.
OBJECTIVE
Periodontitis is a bacterially induced chronic inflammatory disease and a major cause of tooth loss among adults. Toll-like receptors are signal molecules essential for the cellular response to bacterial cell wall components. The aim of this study was to investigate relationships between chronic periodontitis and variations in the TLR4 gene.


METHODS
A total of 171 patients with chronic periodontitis and 218 unrelated controls were genotyped for the Asp299Gly (896A>G) and Thr399Ile (1196C>T) polymorphisms of the TLR4 gene.


RESULTS
Both variants were in nearly complete linkage disequilibrium. No homozygotes for the less common alleles, 299Gly and 399Thr, respectively, were found. The prevalence of the Asp299Gly and the Thr399Ile heterozygotes was 5.3% and 5.0% in controls, and 7.0% and 7.0% in periodontitis patients.


CONCLUSIONS
In conclusion, TLR4 gene polymorphisms were not significantly associated with the susceptibility to, or severity of, chronic periodontitis in our population.
Izakovicova Holla
L
L
Department of Pathological Physiology and Clinic of Stomatology, Medical Faculty, Masaryk University Brno, Czech Republic. holla@med.muni.cz
Buckova
D
D
Fassmann
A
A
Roubalikova
L
L
Vanek
J
J
D000328:Adult; D000367:Age Factors; D000483:Alleles; D002908:Chronic Disease; D018153:Czech Republic; D004812:Epidemiologic Methods; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D010518:Periodontitis / Q000235:genetics* / Q000382:microbiology; D011110:Polymorphism, Genetic / Q000235:genetics; D012737:Sex Factors; D012907:Smoking / Q000009:adverse effects; D051197:Toll-Like Receptor 4 / Q000235:genetics*
D051197:Toll-Like Receptor 4