title: Cutaneous responses to vaccinia in individuals with previous smallpox vaccination.
abstract: The durability of immune responses to smallpox vaccine is a subject of considerable debate. We compared cutaneous vaccinia responses in patients vaccinated in the distant past with vaccine-naïve individuals using serial close-up photographs. The previously vaccinated group had a significantly reduced time course and milder cutaneous reactions. Vaccinated individuals appear to maintain clinically detectable immunity against vaccinia for at least 20 years after smallpox vaccination.
authors.affiliation: Department of Dermatology, Oregon Health and Science University, Center for Health and Healing (CH16D), 3303 SW Bond Ave, Portland, OR 97239-4501, USA. caroccic@ohsu.edu
authors.forename: Eric L
authors.initials: EL
authors.lastname: Simpson
authors.forename: Michelle
authors.initials: M
authors.lastname: Hercher
authors.forename: Erika K
authors.initials: EK
authors.lastname: Hammarlund
authors.forename: Matthew W
authors.initials: MW
authors.lastname: Lewis
authors.forename: Mark K
authors.initials: MK
authors.lastname: Slifka
authors.forename: Jon M
authors.initials: JM
authors.lastname: Hanifin
mesh_terms: D000917:Antibody Formation; D006801:Humans; D007109:Immunity; D008499:Medical Records; D010781:Photography; D012867:Skin / Q000473:pathology*; D012899:Smallpox / Q000276:immunology / Q000517:prevention & control; D012900:Smallpox Vaccine / Q000627:therapeutic use; D013997:Time Factors; D014611:Vaccination; D014615:Vaccinia / Q000473:pathology*
chemical_list: D012900:Smallpox Vaccine