title: CLINICAL case report: falciparum malaria with hemophagocytic syndrome.
abstract: A 30-year-old Japanese woman with falciparum malaria was hospitalized because of fever and renal failure, and prolonged anemia was identified despite the eradication of malaria parasites through anti-malaria therapy. Bone marrow aspiration revealed the presence of macrophages with hemophagocytosis, and serum interleukin (IL)-18 and tumor necrosis factor (TNF)-alpha levels were high in the anemic phase. Hemophagocytosis was confirmed for at least 3 weeks, and prolonged hemophagocytic syndrome is thought to be one of the causes of prolonged anemia in patients with falciparum malaria.
authors.affiliation: Department of Infectious Diseases and Tertiary Emergency Medical Center, Tokyo Metropolitan Bokutoh General Hospital, Tokyo, Japan. infection@bokutoh-hp.metro.tokyo.jp
authors.forename: Kenji
authors.initials: K
authors.lastname: Ohnishi
authors.forename: Keiko
authors.initials: K
authors.lastname: Mitsui
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Komiya
authors.forename: Noriaki
authors.initials: N
authors.lastname: Iwasaki
authors.forename: Akiko
authors.initials: A
authors.lastname: Akashi
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Hamabe
mesh_terms: D000328:Adult; D000818:Animals; D000962:Antimalarials / Q000627:therapeutic use; D005260:Female; D006801:Humans; D051359:Lymphohistiocytosis, Hemophagocytic / Q000150:complications* / Q000188:drug therapy / Q000469:parasitology; D016778:Malaria, Falciparum / Q000150:complications* / Q000188:drug therapy; D008775:Methylprednisolone / Q000627:therapeutic use; D010963:Plasmodium falciparum / Q000254:growth & development
chemical_list: D000962:Antimalarials; D008775:Methylprednisolone