A Possible treatment strategy and clinical factors to estimate the treatment response in Bebesia gibsoni infection.
The effectiveness of combination therapy using clindamycin, metronidazole and doxycycline against canine babesiosis, and the usefulness of platelet count and the plasma C-reactive protein (CRP) concentration as an estimation factor for treatment, were evaluated in four dogs experimentally infected with Babesia gibsoni. The combination therapy successfully eliminated B. gibsoni in peripheral blood in 3 of 4 dogs, however the remaining dog showed obvious uncontrolled relapse after a temporary recovery. In addition, it was shown that CRP levels decreased in an inverse relationship to the recovery of packed cell volume and therefore CRP levels could be used as an optional clinical marker to estimate the response to treatment.
Suzuki
Koretoki
K
Laboratory of Veterinary Internal Medicine, Faculty of Agriculture, Kagoshivma University, Korimoto, Kagoshima, Japan.
Wakabayashi
Haruna
H
Takahashi
Masashi
M
Fukushima
Kenjiro
K
Yabuki
Akira
A
Endo
Yasuyuki
Y
D000818:Animals; D001403:Babesia; D001404:Babesiosis / Q000188:drug therapy / Q000662:veterinary*; D002097:C-Reactive Protein / Q000032:analysis*; D002981:Clindamycin / Q000627:therapeutic use*; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D004318:Doxycycline / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D008795:Metronidazole / Q000627:therapeutic use*; D010976:Platelet Count / Q000662:veterinary
D008795:Metronidazole; D002981:Clindamycin; D002097:C-Reactive Protein; D004318:Doxycycline