Serum ferritin and obstructive coronary artery disease: angiographic correlation.
OBJECTIVE
To verify the possible association between the levels of serum ferritin and the degree of obstructive coronary artery disease.


METHODS
115 patients with coronary arteriography and concomitant evaluation of serum ferritin were studied. The adopted cut-off values were 80 ng/ml for women and 120 ng/ml for men.


RESULTS
The mean ferritin levels for males and females were 133.9 +/- 133.8 ng/ml and 214.6 +/- 217.2 ng/ml, respectively (p=0.047). It was observed that 44.1% of the women had normal serum ferritin levels in comparison to 30.9% of the men (p=0.254). In the patients without obstructive coronary artery disease or with less severe obstructions (group A) the serum ferritin level was 222.3 +/- 325 ng/ml. On the other hand, for those with moderate (group B) and severe obstructions (group C) the levels were 145.6+-83.7 ng/ml and 188.9 +/- 150.6 ng/ml, respectively. There was no correlation between the degree of coronary artery disease and the mean level of serum ferritin. Regarding the cut-off value, the number of women with serum ferritin level > 80 ng/ml in groups B+C or only C was significantly higher than the number of women in group A (ODDS RATIO 9.71 with 95%CI from 1.63 to 57.72). For males there was no significant difference between the number of cases above or below the cut-off values (ODDS RATIO 0.92 with 95%CI from 0.28 to 2.95).


CONCLUSIONS
It was verified that women with serum ferritin levels > 80 ng/mL presented more severe obstructive coronary artery disease than women with lower levels. In men, the serum ferritin level was not a predictor element of the degree of obstruction.
de Godoy
Moacir Fernandes
MF
Faculdade de Medicina de São José do Rio Preto, São José do Rio Preto, SP, Brazil. mfgodoy@netsite.com.br
Takakura
Isabela Thomaz
IT
Machado
Rafael Dinardi
RD
Grassi
Luciano Vaccari
LV
Nogueira
Paulo Roberto
PR
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood* / Q000000981:diagnostic imaging; D005260:Female; D005293:Ferritins / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D012016:Reference Values; D012720:Severity of Illness Index; D012737:Sex Factors
D015415:Biomarkers; D005293:Ferritins