title: Untreated asymptomatic group B streptococcal bacteriuria early in pregnancy and chorioamnionitis at delivery.
abstract: OBJECTIVE
  The objective of the study was to determine the frequency of adverse pregnancy outcomes in women with untreated asymptomatic group B beta-hemolytic streptococcal (GBS) bacteriuria during pregnancy.
  
  
  METHODS
  In this retrospective cohort, all women with antepartum GBS bacteriuria in a research registry were included. Controls were women with negative urine cultures. The frequency of chorioamnionitis was compared between groups. Chorioamnionitis was defined as intrapartum fever, fetal tachycardia, and histologic inflammation of the membranes.
  
  
  RESULTS
  One hundred twenty-two women with bacteriuria (study group) and 183 women with negative antepartum cultures (controls) were included. There were no differences in demographic characteristics between the groups. Thirty-one women (10.2%) had chorioamnionitis. Untreated GBS bacteriuria was associated with chorioamnionitis after controlling for confounding variables, adjusted odds ratio 7.2 (95% confidence interval 2.4 to 21.2). There was also a significant positive rank correlation between increasing colony count of GBS bacteriuria and increasing grade of chorioamnionitis (P = .02).
  
  
  CONCLUSIONS
  Untreated antepartum GBS bacteriuria is associated with chorioamnionitis.
authors.affiliation: Division of Reproductive Infectious Diseases and Immunology, Department of Obstetrics, Gynecology, and Reproductive Sciences, Magee-Womens Hospital of the University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
authors.forename: Brenna L
authors.initials: BL
authors.lastname: Anderson
authors.forename: Hyagriv N
authors.initials: HN
authors.lastname: Simhan
authors.forename: Kathryn M
authors.initials: KM
authors.lastname: Simons
authors.forename: Harold C
authors.initials: HC
authors.lastname: Wiesenfeld
mesh_terms: D000293:Adolescent; D000328:Adult; D001437:Bacteriuria / Q000453:epidemiology* / Q000382:microbiology*; D016022:Case-Control Studies; D002821:Chorioamnionitis / Q000453:epidemiology*; D005260:Female; D006801:Humans; D007363:Intensive Care Units, Neonatal / Q000706:statistics & numerical data; D010414:Pennsylvania / Q000453:epidemiology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000382:microbiology*; D047928:Premature Birth / Q000453:epidemiology; D012042:Registries; D012189:Retrospective Studies; D013290:Streptococcal Infections / Q000453:epidemiology*; D013292:Streptococcus agalactiae