title: Identifying motivations and barriers to patient participation in clinical trials.
abstract: BACKGROUND
  This study assessed cancer patients' knowledge and attitudes towards clinical trials (CTs).
  
  
  METHODS
  A survey was administered to 100/141 cancer outpatients.
  
  
  RESULTS
  82% respondents had heard of CTs, but many could only provide limited definitions and perceived them as high risk. About half had previously been approached to participate in a trial, and 67% had agreed to participate. Factors influencing participation in trials, barriers to recruitment, and suggestions for increased recruitment in clinical trials were identified.
  
  
  CONCLUSIONS
  The findings suggest general support of CTs. Education programs are needed to raise awareness, reduce fears, and dispel myths about CT participation.
authors.affiliation: Princess Margaret ospital, Toronto, ON, Canada. jennifer.jones@uhn.on.ca
authors.forename: Jennifer M
authors.initials: JM
authors.lastname: Jones
authors.forename: Joyce
authors.initials: J
authors.lastname: Nyhof-Young
authors.forename: Jakov
authors.initials: J
authors.lastname: Moric
authors.forename: Audrey
authors.initials: A
authors.lastname: Friedman
authors.forename: Woody
authors.initials: W
authors.lastname: Wells
authors.forename: Pamela
authors.initials: P
authors.lastname: Catton
mesh_terms: D002986:Clinical Trials as Topic; D003657:Decision Making; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009042:Motivation; D009369:Neoplasms / Q000523:psychology / Q000628:therapy*; D010358:Patient Participation / Q000523:psychology* / Q000706:statistics & numerical data; D018579:Patient Selection; D011795:Surveys and Questionnaires