title: Relationship between anxiety and gastric sensorimotor function in functional dyspepsia.
abstract: OBJECTIVE
  To investigate the relationship between anxiety and gastric sensorimotor function in patients with (hypersensitive) functional dyspepsia (FD). Comorbidity between FD and anxiety disorders is high. In FD, epigastric pain is associated with gastric hypersensitivity and neuroticism, a personality trait related to anxiety. Experimentally induced anxiety in healthy volunteers is associated with changes in sensorimotor function of the proximal stomach.
  
  
  METHODS
  A total of 139 patients with FD (n = 102 women) underwent a barostat investigation to determine gastric compliance, meal accommodation, and thresholds for discomfort and pain. Anxiety was measured by the State-Trait Anxiety Inventory (STAI) scale (anxiety as a stable personality trait) and the STAI-State scale (momentary anxiety). The anxiety subscale of the Hospital Anxiety and Depression Scale (HADS-A) was filled out to detect comorbid anxiety disorders.
  
  
  RESULTS
  Hyper- and normosensitive patients had similar anxiety scores, but gastric compliance was significantly lower in hypersensitive patients (11.4 versus 32.8 ml/mm Hg; p < .001). In the whole patient group, no significant correlations between STAI scores and gastric sensorimotor function were found. In hypersensitive patients (n = 53, 43 women), state anxiety was negatively correlated with discomfort threshold (rho = -.49; p = .001), pain threshold (rho = -.48; p = .02), and gastric compliance (rho = -.46; p = .002). These results were confirmed by multiple linear and logistic regression analyses.
  
  
  CONCLUSIONS
  In hypersensitive patients with FD, state anxiety is significantly and negatively correlated with discomfort threshold, pain threshold, and compliance. These results strengthen the hypothesis that anxiety is important in FD, especially in hypersensitive patients.
authors.affiliation: Department of Pathophysiology, Gastroenterology Section, University Hospital Gasthuisberg, Leuven, Belgium. Lukas.VanOudenhove@med.kuleuven.be
authors.forename: Lukas
authors.initials: L
authors.lastname: Van Oudenhove
authors.forename: Joris
authors.initials: J
authors.lastname: Vandenberghe
authors.forename: Brecht
authors.initials: B
authors.lastname: Geeraerts
authors.forename: Rita
authors.initials: R
authors.lastname: Vos
authors.forename: Philippe
authors.initials: P
authors.lastname: Persoons
authors.forename: Koen
authors.initials: K
authors.lastname: Demyttenaere
authors.forename: Benjamin
authors.initials: B
authors.lastname: Fischler
authors.forename: Jan
authors.initials: J
authors.lastname: Tack
mesh_terms: D000328:Adult; D001007:Anxiety; D016022:Case-Control Studies; D004415:Dyspepsia / Q000503:physiopathology* / Q000523:psychology*; D004435:Eating; D005260:Female; D005769:Gastrointestinal Motility; D006801:Humans; D008297:Male; D008875:Middle Aged; D010146:Pain; D013270:Stomach / Q000294:innervation / Q000503:physiopathology*