[Expression and significance of TRAIL protein and mRNA in hemangioma].
OBJECTIVE
To detect the expression of TRAIL protein and mRNA in hemangiomas and vascular malformations.


METHODS
Sections of 33 proliferative hemangiomas,28 involuting hemangiomas and 29 vascular malformations were immunostained for TRAIL protein, TRAIL mRNA was examined by in situ hybridization in these tissue.


RESULTS
The TRAIL protein positive rates in proliferative hemangiomas, involuting hemangiomas, vascular malformations and normal skins were respectively 45.45% (15/33), 78.57% (22/28), 0% and 0%. There were significant differences among the four pathologies (P < 0.01). The difference between proliferative hemangiomas and involuting hemangiomas was also significant (P < 0.01). The TRAIL mRNA positive rates were 66.67% (11/33), 89.29 (25/28), 0% and 0% respectively. There were also significant differences among the four pathologies (P < 0.01). The difference between proliferative hemangiomas and involuting hemangiomas was also significant (P < 0.01).


CONCLUSIONS
TRAIL could induce endothelial apoptosis and cause regression of hemangiomas.
Lin
Hui
H
Department of Laser and Plastic Surgery, The First Affiliation Hospital of Guangxi Traditional Chinese Medical University. Nanning 530023, China.
Chen
Shi-Hai
SH
Yin
Guo-Qian
GQ
Li
Dong
D
Liu
Qing-Feng
QF
D017209:Apoptosis; D005260:Female; D006391:Hemangioma / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D017403:In Situ Hybridization; D007231:Infant, Newborn; D008297:Male; D008833:Microcirculation; D012333:RNA, Messenger / Q000235:genetics; D053221:TNF-Related Apoptosis-Inducing Ligand / Q000235:genetics / Q000378:metabolism*; D054079:Vascular Malformations / Q000378:metabolism / Q000473:pathology
D012333:RNA, Messenger; D053221:TNF-Related Apoptosis-Inducing Ligand