Hemorrhagic syndrome-like disease in calves with bovine viral diarrhea and mucosal disease complex.
BACKGROUND
Bovine viral diarrhea virus (BVDV) infection is one of the causes of hemorrhagic diathesis in cattle but there have been limited field studies about that condition.


OBJECTIVE
To identify the cause of hemorrhagic diathesis in calves and describe its clinical findings.


METHODS
Five calves from a farm with 150 dairy cows.


METHODS
Clinical examination of the calves was performed. After blood samples were obtained from 2 calves, whole blood, sera, and leukocyte samples were used for hematologic and hemostatic examinations, neutralization tests, virus isolation, and viral genome sequencing.


RESULTS
The calves had moderate pyrexia, dullness, serous or mucous nasal discharge, and petechial and ecchymotic hemorrhages on mucosal surfaces. Severe thrombocytopenia and anemia were identified on hematologic examinations. All calves died within 10 days of the onset of clinical signs. Virologic examinations identified BVDV as the causative agent of the disease.


CONCLUSIONS
This paper identifies a hemorrhagic syndrome-like disease in calves with bovine viral diarrhea and mucosal disease complex in Turkey.
Dabak
Murat
M
Department of Internal Medicine, Veterinary Teaching Hospital, Firat University, Elazig, Turkey. mdabak@hotmail.com
Karapinar
Tolga
T
Gulacti
Irem
I
Bulut
Hakan
H
Kizil
Omer
O
Aydin
Suleyman
S
D000818:Animals; D000831:Animals, Newborn; D001483:Base Sequence; D001912:Bovine Virus Diarrhea-Mucosal Disease / Q000097:blood / Q000175:diagnosis* / Q000473:pathology; D002417:Cattle; D004279:DNA, Viral / Q000032:analysis; D001908:Diarrhea Viruses, Bovine Viral / Q000302:isolation & purification*; D030243:Hemorrhagic Syndrome, Bovine / Q000097:blood / Q000175:diagnosis* / Q000473:pathology; D008969:Molecular Sequence Data; D009500:Neutralization Tests / Q000662:veterinary; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000662:veterinary; D016415:Sequence Alignment
D004279:DNA, Viral