Antimicrobial drugs and community-acquired Clostridium difficile-associated disease, UK.
In a population-based case-control study of community acquired Clostridium difficile-associated disease (CDAD), we matched 1,233 cases to 12,330 controls. CDAD risk increased 3-fold with use of any antimicrobial agent and 6-fold with use of fluoroquinolones. Prior use of antimicrobial agents did not affect risk for CDAD after 6 months.
Delaney
J A Chris
JA
McGill University Health Center, Montreal, Quebec, Canada.
Dial
Sandra
S
Barkun
Alan
A
Suissa
Samy
S
D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000494:pharmacology; D016022:Case-Control Studies; D016360:Clostridioides difficile / Q000187:drug effects*; D003015:Clostridium Infections / Q000188:drug therapy* / Q000453:epidemiology; D017714:Community-Acquired Infections / Q000453:epidemiology / Q000382:microbiology; D016208:Databases, Factual; D024901:Drug Resistance, Multiple, Bacterial / Q000187:drug effects*; D006801:Humans; D006113:United Kingdom / Q000453:epidemiology
D000900:Anti-Bacterial Agents