title: Isoflavanones from Uraria picta and their antimicrobial activity.
abstract: Two isoflavanones, 5,7-dihydroxy-2'-methoxy-3',4'-methylenedioxyisoflavanone (2) and 4',5-dihydroxy-2',3'-dimethoxy-7-(5- hydroxyoxychromen-7yl)-isoflavanone (4) along with six known compounds including isoflavanones, triterpenes and steroids were isolated from the roots of Uraria picta. The structures of these compounds were established unambiguously by UV, IR, MS and a series of 1D and 2D NMR analyses. The minimum inhibitory concentrations (MIC) for these compounds were found to be in the range of 12.5-200 microg/ml against bacteria (both Gram positive and Gram negative) and fungi.
authors.affiliation: Phytochemistry Research Laboratories, Department of Pharmaceutical Sciences, University of Strathclyde, 27 Taylor Street, Glasgow G4 ONR, Scotland, UK.
authors.forename: M Mukhlesur
authors.initials: MM
authors.lastname: Rahman
authors.forename: Simon
authors.initials: S
authors.lastname: Gibbons
authors.forename: Alexander I
authors.initials: AI
authors.lastname: Gray
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D029624:Ferns / Q000737:chemistry*; D005658:Fungi / Q000187:drug effects; D007529:Isoflavones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification; D013256:Steroids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: C523335:4',5-dihydroxy-2',3'-dimethoxy-7-(5- hydroxyoxychromen-7yl)-isoflavanone; C523334:5,7-dihydroxy-2'-methoxy-3',4'-methylenedioxyisoflavanone; D000890:Anti-Infective Agents; D007529:Isoflavones; D010936:Plant Extracts; D013256:Steroids; D014315:Triterpenes