title: Low dose of rectal thiopental sodium for pediatric sedation in spiral computed tomography study.
abstract: BACKGROUND
  The aim of this study was to determine the effectiveness of reduced new dose in rectal sedation by thiopental sodium for computed tomography (CT) diagnostic imaging.
  
  
  METHODS
  A total of 90 children (mean age, 24.21 month +/- 13.63 [standard deviation]) underwent spiral CT study after rectal administration of thiopental sodium injection solution. The new dose ranged from 15 to 25 mg/kg with a total dose of 350 mg. The percentage of success and adverse reaction were evaluated.
  
  
  RESULTS
  Sedation was successful in 98% of infants and children with an average time of 8.04 min +/- 6.87 (standard deviation). One of the cases found desaturation, two experienced vomiting, 14 found rectal defecation, and two experienced hyperactivity. No prolonged sedation was observed.
  
  
  CONCLUSIONS
  Rectal administration of thiopental sodium for pediatric CT imaging is safe and effective even for hyperextend position by new reduced dose of the drug. This procedure could be easily done in the CT department under supervision of the radiologist.
authors.affiliation: Spiral CT Department, Noor Medical Imaging Center, Tehran, Iran. akhlaghpoor@nmri-ir.com
authors.forename: Shahram
authors.initials: S
authors.lastname: Akhlaghpoor
authors.forename: Abbas Arjmand
authors.initials: AA
authors.lastname: Shabestari
authors.forename: Mohsen Shojaei
authors.initials: MS
authors.lastname: Moghdam
mesh_terms: D000285:Administration, Rectal; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D016292:Procedural Sedation / Q000379:methods*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage*; D007223:Infant; D008297:Male; D009333:Neck / Q000000981:diagnostic imaging; D015203:Reproducibility of Results; D012189:Retrospective Studies; D013701:Temporal Bone / Q000000981:diagnostic imaging; D013704:Temporomandibular Joint / Q000000981:diagnostic imaging; D013874:Thiopental / Q000008:administration & dosage*; D036542:Tomography, Spiral Computed / Q000379:methods*
chemical_list: D006993:Hypnotics and Sedatives; D013874:Thiopental