title: Hepatocellular carcinoma with peritoneal dissemination which was regressed during vitamin K2 and vitamin E administration.
abstract: A 65-year-old man with positive anti-hepatitis C antibody and chronic renal failure was diagnosed as having a ruptured hepatocellular carcinoma (HCC) based on computed tomography (CT). The patient underwent transcatheter arterial embolization (TAE) for the HCC. After one more session of TAE, the patient underwent surgery. But HCC seeding peritoneally was pointed out. Vitamin K2 and vitamin E were administered as a conservative treatment. Six months after starting vitamins K2 and E, the primary tumor did not increase in size and intraperitoneal dissemination disappeared on CT with a significant decrease of alpha-fetoprotein. Even though this is only one case, combination therapy of vitamin K2 and E may induce growth suppression of HCC.
authors.affiliation: Department of Internal Medicine, Tone Chuo Hospital, Numata. tcht-otsuka@tonehoken.or.jp
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Otsuka
authors.forename: Satoshi
authors.initials: S
authors.lastname: Hagiwara
authors.forename: Hiroki
authors.initials: H
authors.lastname: Tojima
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Yoshida
authors.forename: Tetsushi
authors.initials: T
authors.lastname: Takahashi
authors.forename: Kazumi
authors.initials: K
authors.lastname: Nagasaka
authors.forename: Shinichi
authors.initials: S
authors.lastname: Tomioka
authors.forename: Tetsu
authors.initials: T
authors.lastname: Ando
authors.forename: Kunio
authors.initials: K
authors.lastname: Takeuchi
authors.forename: Takayuki
authors.initials: T
authors.lastname: Kori
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Ohno
authors.forename: Satoru
authors.initials: S
authors.lastname: Kakizaki
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Takagi
authors.forename: Masatomo
authors.initials: M
authors.lastname: Mori
mesh_terms: D000368:Aged; D017209:Apoptosis / Q000187:drug effects; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy* / Q000556:secondary*; D003131:Combined Modality Therapy; D004359:Drug Therapy, Combination; D004621:Embolization, Therapeutic; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology*; D008297:Male; D009366:Neoplasm Seeding; D010534:Peritoneal Neoplasms / Q000188:drug therapy* / Q000556:secondary*; D012422:Rupture, Spontaneous; D014810:Vitamin E / Q000627:therapeutic use*; D024482:Vitamin K 2 / Q000627:therapeutic use*; D014815:Vitamins / Q000627:therapeutic use
chemical_list: D014815:Vitamins; D024482:Vitamin K 2; D014810:Vitamin E