The intimate relationship between gut and joint in spondyloarthropathies.
OBJECTIVE
The aim of this article is to highlight recent progress in the combined joint and gut disease in spondyloarthropathies.


RESULTS
A set of genes has been identified that are differentially expressed in the colon of spondyloarthropathy and Crohn's disease patients. Reduction of human leukocyte antigen B27 (HLA B27) misfolding by additional beta2-microglobulin in HLA B27 transgenic rats unexpectedly increased disease severity, with more similarities to spondyloarthropathies. By contrast, colitis disappeared.


CONCLUSIONS
Human genomic studies combined with animal model research provide new clues concerning the common pathogenesis of spondyloarthropathy and Crohn's disease, further substantiating the unique relationship between gut and joint inflammation.
Jacques
Peggy
P
Department of Internal Medicine, Rheumatology, University Hospital of Ghent, Ghent, Belgium.
Mielants
Herman
H
Coppieters
Ken
K
De Vos
Martine
M
Elewaut
Dirk
D
D000818:Animals; D030801:Animals, Genetically Modified; D001169:Arthritis, Experimental / Q000473:pathology; D003424:Crohn Disease / Q000150:complications* / Q000235:genetics / Q000503:physiopathology; D005759:Gastroenteritis / Q000150:complications*; D020022:Genetic Predisposition to Disease; D015796:HLA-B27 Antigen / Q000235:genetics* / Q000502:physiology; D006801:Humans; D053473:Nod2 Signaling Adaptor Protein / Q000235:genetics*; D012307:Risk Factors; D025242:Spondylarthropathies / Q000150:complications* / Q000235:genetics / Q000503:physiopathology; D001613:beta 2-Microglobulin / Q000235:genetics
D015796:HLA-B27 Antigen; C429018:NOD2 protein, human; D053473:Nod2 Signaling Adaptor Protein; D001613:beta 2-Microglobulin