title: Beneficial use of Cetaphil moisturizing cream as part of a daily skin care regimen for individuals with rosacea.
abstract: BACKGROUND
  Rosacea is a common and chronic disorder characterized by flushing, erythema, papules, pustules, and telangiectasia on the central part of the face. Because the facial skin of individuals with rosacea is particularly sensitive, irritants can trigger a worsening of the signs and symptoms of the disease. This enhanced sensitivity is thought to be linked to a deficient stratum corneum barrier function.
  
  
  METHODS
  In the present study, 20 individuals receiving twice-daily applications of metronidazole 0.75% gel for at least 15 days applied a gentle non-irritating moisturizing cream (Cetaphil Moisturizing Cream) twice daily for 15 days on one half of the face; the other side remained treated with metronidazole only and served as the control.
  
  
  RESULTS
  Clinical assessments, confirmed by biophysical measurements (electrical capacitance, transepidermal water loss (TEWL), and lactic acid stinging test), provided evidence that the moisturizer contributed to the restoration of the skin barrier: skin dryness, roughness and desquamation were much improved and skin sensitivity was significantly reduced. Skin properties and skin discomfort were also greatly enhanced and the patients were very satisfied with the product.
  
  
  CONCLUSIONS
  It can thus be concluded that in the management of rosacea, basic skin care regimens, including daily use of a therapeutic moisturizer, offer optimal benefits.
authors.affiliation: PERITESCO, Paris, France. sabine.laquieze@peritesco.com
authors.forename: Sabine
authors.initials: S
authors.lastname: Laquieze
authors.forename: Janusz
authors.initials: J
authors.lastname: Czernielewski
authors.forename: Eszter
authors.initials: E
authors.lastname: Baltas
mesh_terms: D000279:Administration, Cutaneous; D000293:Adolescent; D000328:Adult; D000368:Aged; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000627:therapeutic use; D004334:Drug Administration Schedule; D004338:Drug Combinations; D025802:Electric Capacitance; D005233:Fatty Alcohols / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D005782:Gels; D006801:Humans; D019344:Lactic Acid; D008297:Male; D008795:Metronidazole / Q000008:administration & dosage / Q000627:therapeutic use; D008875:Middle Aged; D011409:Propylene Glycols / Q000008:administration & dosage / Q000627:therapeutic use*; D012393:Rosacea / Q000188:drug therapy* / Q000473:pathology; D012720:Severity of Illness Index; D017592:Skin Care; D012967:Sodium Dodecyl Sulfate / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome; D014870:Water Loss, Insensible
chemical_list: D000890:Anti-Infective Agents; D004338:Drug Combinations; D005233:Fatty Alcohols; D005782:Gels; D011409:Propylene Glycols; C011189:cetyl alcohol, propylene glycol, sodium lauryl sulfate non-lipid cleansing lotion; D008795:Metronidazole; D019344:Lactic Acid; D012967:Sodium Dodecyl Sulfate