Perforating neutrophilic and granulomatous dermatitis of the newborn--a clue to immunodeficiency.
We report two newborns with a widespread cutaneous eruption consisting of discrete papules which evolved into vesicles, pustules, crusts, and ulcers. These healed over a 2-week period with scarring. Histopathology showed three main features--histiocytic granulomas, neutrophilic infiltration, and transepidermal elimination of degenerated collagen and debris through hair follicles. Both patients had congenital immunodeficiency. This skin condition of the newborn, with distinct clinical and histopathologic features, is a manifestation of immunodeficiency that has not been previously described.
Torrelo
Antonio
A
Department of Dermatology, Hospital del Niño Jesús, Madrid, Spain. atorrelo@aedv.es
Vera
Angel
A
Portugués
Mar
M
de Prada
Inmaculada
I
Sanz
Andrés
A
Colmenero
Isabel
I
Zulaica
Ander
A
de Lucas
Raúl
R
Fraga
Javier
J
Pedraz
Javier
J
Fontán
Sindo
S
Zambrano
Antonio
A
D000361:Agammaglobulinemia / Q000150:complications*; D002097:C-Reactive Protein / Q000032:analysis; D003872:Dermatitis / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D005260:Female; D015726:Giant Cells / Q000473:pathology; D006099:Granuloma / Q000276:immunology* / Q000473:pathology; D006644:Histiocytes / Q000473:pathology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009077:Mucins / Q000378:metabolism; D020556:Neutrophil Infiltration; D013601:T-Lymphocytes / Q000276:immunology*
D009077:Mucins; D002097:C-Reactive Protein