Regulation of excitation by glycine receptors.
Our knowledge of glycine receptor (GlyR) regulation of excitation has advanced significantly in recent years. GlyRs are widespread in the CNS, are heterogeneous, and undergo developmental changes. Activation of GlyRs of immature neurons induces outflow of Cl( - ), membrane depolarization, neuronal excitation, calcium influx, and transmitter release, in contrast to the inhibitory effects these receptors have in mature neurons. Thus, GlyRs are important for neuronal excitability in both the developing and the mature CNS. This chapter is an overview of selective studies on the newly discovered roles of GlyRs in regulating neuronal excitation, and inhibition, particularly in the upper brain areas.
Ye
Jiang-Hong
JH
Department of Anesthesiology, UMDNJ, New Jersey Medical School, Newark, NJ 07103, USA. ye@umdnj.edu
D000818:Animals; D002118:Calcium / Q000502:physiology; D002531:Cerebellum / Q000254:growth & development / Q000502:physiology; D018118:Chloride Channels / Q000502:physiology; D002712:Chlorides / Q000378:metabolism; D019706:Excitatory Postsynaptic Potentials / Q000502:physiology*; D018698:Glutamic Acid / Q000502:physiology; D005998:Glycine / Q000502:physiology*; D006801:Humans; D015640:Ion Channel Gating / Q000502:physiology*; D008564:Membrane Potentials / Q000502:physiology; D008636:Mesencephalon / Q000254:growth & development / Q000502:physiology; D009433:Neural Inhibition / Q000502:physiology*; D018377:Neurotransmitter Agents / Q000378:metabolism; D017729:Presynaptic Terminals / Q000502:physiology; D051381:Rats; D018009:Receptors, Glycine / Q000502:physiology*; D013116:Spinal Cord / Q000254:growth & development / Q000502:physiology; D005680:gamma-Aminobutyric Acid / Q000502:physiology
D018118:Chloride Channels; D002712:Chlorides; D018377:Neurotransmitter Agents; D018009:Receptors, Glycine; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid; D002118:Calcium; D005998:Glycine