title: Study of drug resistant cases among new pulmonary tuberculosis patients attending a tuberculosis center, Yangon, Myanmar.
abstract: A cross-sectional descriptive study was carried out at a tuberculosis center, Yangon, Myanmar from October 2003 to July 2004 to analyze the drug susceptibility of new sputum smear positive pulmonary tuberculosis patients. A total of 202 Mycobacterium tuberculosis isolates were tested for resistance to isoniazid, streptomycin, rifampicin and ethambutol. Resistance to at least one anti-tuberculosis drug was documented in 32 (15.8%) isolates. Monoresistance (resistance to one drug) was noted in 15 (7.4%) isolates and poly-resistance (resistance to two or more drugs) was noted in 17 (9.4%) isolates, including 8 (4.0%) multi-drug resistant isolates (resistance to at least isoniazid and rifampicin). Total resistance to individual anti-tuberculosis drugs were: isoniazid (29, 14.3%), streptomycin (11, 5.4%), rifampicin (10, 4.9%) and ethambutol (1, 0.5%). The demographic data and possible contributing factors of drug resistance were evaluated among the drug resistant patients. Poly-resistant cases had significantly longer intervals between symptom appearance and achieving effective anti-tuberculosis treatment than mono-resistant cases (p = 0.015).
authors.affiliation: Bacteriology Research Division, Department of Medical Research (Lower Myanmar), No 5 Ziwaka Road, Dagon PO, Yangon 11191, Myanmar. hhlaing@mptmail.net.mm
authors.forename: Wah Wah
authors.initials: WW
authors.lastname: Aung
authors.forename: Ti
authors.initials: T
authors.lastname: Ti
authors.forename: Kyu Kyu
authors.initials: KK
authors.lastname: Than
authors.forename: Myat
authors.initials: M
authors.lastname: Thida
authors.forename: Mar Mar
authors.initials: MM
authors.lastname: Nyein
authors.forename: Yin Yin
authors.initials: YY
authors.lastname: Htun
authors.forename: Win
authors.initials: W
authors.lastname: Maung
authors.forename: Aye
authors.initials: A
authors.lastname: Htun
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000995:Antitubercular Agents / Q000494:pharmacology*; D003430:Cross-Sectional Studies; D024881:Drug Resistance, Bacterial; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D002052:Myanmar; D009169:Mycobacterium tuberculosis / Q000145:classification / Q000187:drug effects*; D018088:Tuberculosis, Multidrug-Resistant; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy* / Q000382:microbiology
chemical_list: D000995:Antitubercular Agents