Consequences of the natural propensity of Leishmania and HIV-1 to target dendritic cells.
Recent studies have shown that both Leishmania and HIV type-1 (HIV-1) hijack dendritic cell (DC) functions to escape immune surveillance using an array of elaborate strategies. Leishmania has developed a variety of adaptations to disrupt cellular defense mechanisms, whereas HIV-1 targets DCs to achieve a more efficient dissemination. The capacity of Leishmania and HIV-1 to target DCs through a common cell-surface molecule, namely DC-SIGN (dendritic cell specific ICAM-3-grabbing non-integrin), points to a possible dangerous liaison between these two pathogens. This review explores our knowledge of how Leishmania and HIV-1 interact dynamically with DCs, and how they exploit this cell type for their reciprocal benefit.
Garg
Ravendra
R
Centre de Recherche en Infectiologie, Centre Hospitalier de l'Université Laval, 2705 Boulevard Laurier, RC-709, Université Laval, Québec, G1V 4G2, Canada.
Trudel
Nathalie
N
Tremblay
Michel J
MJ
D000818:Animals; D015815:Cell Adhesion Molecules / Q000276:immunology; D016207:Cytokines / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology / Q000469:parasitology* / Q000821:virology*; D015658:HIV Infections / Q000276:immunology* / Q000469:parasitology; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D018314:Leishmania infantum / Q000276:immunology*; D007898:Leishmaniasis, Visceral / Q000276:immunology* / Q000821:virology; D011956:Receptors, Cell Surface / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology / Q000469:parasitology / Q000821:virology
D015815:Cell Adhesion Molecules; D016207:Cytokines; D011956:Receptors, Cell Surface