[Lipid peroxidation and antioxidant levels in patients with laryngeal carcinoma].
OBJECTIVE
Reactive oxygen species (ROS) play an important role in the pathogenesis of cancer. The aim of this study was to investigate the extent of lipid peroxidation and ROS in laryngeal cancer tissues.


METHODS
We determined glutathione (GSH) and malondialdehyde (MDA) activities as markers of lipid peroxidation in laryngeal tumor specimens and tumor-free adjacent tissues of 30 patients with squamous cell carcinoma.


RESULTS
Compared to the tumor-free specimens, the level of GSH was significantly low (p<0.001) whereas MDA, a lipid peroxidation product, showed a significant increase (p<0.01) in cancer tissues. No significant differences were found in MDA and GSH levels between patients with early (n=14) and advanced (n=16) tumor stages (p>0.05).


CONCLUSIONS
Decreased antioxidant capacity of laryngeal cancer tissues results in elevation of free oxygen radicals and increased lipid peroxidation. Free radical metabolism may be involved in the pathogenesis of laryngeal cancers.
Yilmaz
Yavuz Fuat
YF
Department of Otolaryngology, Ankara Numune Training and Research Hospital, Ankara, Turkey. dryavuzfuatyilmaz@mynet.com
Akbiyik
Filiz
F
Tuncel
Umit
U
Unal
Adnan
A
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000975:Antioxidants / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism*; D016022:Case-Control Studies; D005260:Female; D005978:Glutathione / Q000378:metabolism; D006801:Humans; D007822:Laryngeal Neoplasms / Q000378:metabolism*; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D008875:Middle Aged
D000975:Antioxidants; D008315:Malondialdehyde; D005978:Glutathione