Mycobacterium tuberculosis and its ability to resist immunity.
Resistance to tuberculosis involves a balance between the immune activation required to restrict the infection and the immune regulation required to prevent collateral damage to surrounding tissues. We explore here the hypothesis that genetic diversity of Mycobacterium tuberculosis provides an opportunity to tilt this balance in favour of the pathogen through variations in innate immune signalling.
Young
Douglas
D
Imperial College London, South Kensington Campus, London, UK.
O'Garra
Anne
A
D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology*; D018448:Models, Immunological; D009169:Mycobacterium tuberculosis / Q000235:genetics / Q000276:immunology*; D010641:Phenotype; D014376:Tuberculosis / Q000235:genetics / Q000276:immunology*