A highly efficient cycloaddition of vinylarenes with electron-deficient alkynes affording 1,2-disubstituted-3,4-dihydronaphthalenes catalysed by N,N-dimethylformamide dimethyl acetal.
1,2-Disubstituted-3,4-dihydronaphthalenes could be conveniently synthesized with high yields by the cycloaddition reactions of easily available vinylarenes with electron-deficient alkynes such as dimethyl, or diethyl acetylenedicarboxylate, methyl phenylpropiolate in the presence of DMF.DMA (N,N-dimethylformamide dimethyl acetal) as organocatalyst.
Jiang
Jia-Li
JL
Department of Chemistry, Tsinghua University, Innovative Catalysis Program, Key Laboratory of Organic Optoelectronics & Molecular Engineering of Ministry of Education, Beijing, China.
Ju
Jia
J
Hua
Ruimao
R