Two new bisorbicillinoids isolated from a deep-sea fungus, Phialocephala sp. FL30r.
Two new bisorbicillinoids, named oxosorbiquinol (1) and dihydrooxosorbiquinol (2), were isolated from a deep-sea fungus, Phialocephala sp., and their structures established using spectroscopic methods. The absolute configurations of 1 and 2 were determined by their biosynthesis route and analysis of the CD spectrum. Their cytotoxic effects on P388, A-549, HL60, BEL7402 and K562 cell lines were examined by the MTT method.
Li
Dehai
D
Key Laboratory of Marine Drugs, Chinese Ministry of Education, PR China.
Wang
Fengping
F
Cai
Shengxin
S
Zeng
Xiang
X
Xiao
Xiang
X
Gu
Qianqun
Q
Zhu
Weiming
W
D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification / Q000494:pharmacology; D001203:Ascomycota / Q000737:chemistry*; D045744:Cell Line, Tumor; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002942:Circular Dichroism; D004224:Diterpenes / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D013055:Spectrophotometry, Infrared; D013778:Tetrazolium Salts; D013844:Thiazoles
D000903:Antibiotics, Antineoplastic; D004224:Diterpenes; D013778:Tetrazolium Salts; D013844:Thiazoles; C522438:dihydrooxosorbiquinol; C522437:oxosorbiquinol; C022616:thiazolyl blue