title: New aureothin derivative, alloaureothin, from Streptomyces sp. MM23.
abstract: A new polypropionate alloaureothin (1) possessing a nitro group, together with a known polypropionate aureothin (2), was isolated from mycelium of Streptomyces sp. MM23. The structure was determined on the basis of spectroscopic data. 1 exhibited growth inhibitory effect against human fibrosarcoma HT1080 cells with an IC50 value of 30 microM.
authors.affiliation: Japan Biological Information Research Center (JBIRC), Japan Biological Informatics Consortium (JBIC).
authors.forename: Jun-ya
authors.initials: JY
authors.lastname: Ueda
authors.forename: Junko
authors.initials: J
authors.lastname: Hashimoto
authors.forename: Aya
authors.initials: A
authors.lastname: Nagai
authors.forename: Takuji
authors.initials: T
authors.lastname: Nakashima
authors.forename: Hisayuki
authors.initials: H
authors.lastname: Komaki
authors.forename: Kozue
authors.initials: K
authors.lastname: Anzai
authors.forename: Shigeaki
authors.initials: S
authors.lastname: Harayama
authors.forename: Takayuki
authors.initials: T
authors.lastname: Doi
authors.forename: Takashi
authors.initials: T
authors.lastname: Takahashi
authors.forename: Kazuo
authors.initials: K
authors.lastname: Nagasawa
authors.forename: Tohru
authors.initials: T
authors.lastname: Natsume
authors.forename: Motoki
authors.initials: M
authors.lastname: Takagi
authors.forename: Kazuo
authors.initials: K
authors.lastname: Shin-ya
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002851:Chromatography, High Pressure Liquid; D002867:Chromones / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D025282:Mycelium / Q000737:chemistry; D012988:Soil Microbiology; D021241:Spectrometry, Mass, Electrospray Ionization; D013056:Spectrophotometry, Ultraviolet; D013302:Streptomyces / Q000737:chemistry*
chemical_list: D000903:Antibiotics, Antineoplastic; D002867:Chromones; C012198:aureothin