TXNIP links redox circuitry to glucose control.
Thioredoxin-interacting protein (TXNIP) binds and inhibits the reducing activity of thioredoxin. A new study (Parikh et al., 2007) implicates this redox rheostat as a negative regulator of peripheral glucose metabolism in humans. Investigators combined human physiology, genomic screening, and cell-based genetic studies to highlight TNXIP as a potential culprit in the pathogenesis of type 2 diabetes.
Muoio
Deborah M
DM
Sarah W. Stedman Nutrition and Metabolism Center and Departments of Pharmacology & Cancer Biology and Medicine, Duke University Medical Center, Durham, NC 27710, USA. muoio@duke.edu
D002352:Carrier Proteins / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000209:etiology / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D010084:Oxidation-Reduction; D013879:Thioredoxins / Q000378:metabolism*
D002352:Carrier Proteins; C486715:TXNIP protein, human; D013879:Thioredoxins; D005947:Glucose