title: Antimicrobial activity of rationally designed amino terminal modified peptides.
abstract: Series of short amino terminal modified cationic peptides were designed and synthesized. All of the synthesized compounds were tested against gram-positive as well as gram-negative bacterial strain. Some of the compounds exhibit potent antibacterial activity and no hemolytic activity even at high dose level (1000 microg/mL) in mammalian erythrocytes was observed.
authors.affiliation: Peptide Research Laboratory, Institute of Genomics and Integrative Biology, Mall Road, Delhi 110007, India.
authors.forename: Gopal Singh
authors.initials: GS
authors.lastname: Bisht
authors.forename: Diwan S
authors.initials: DS
authors.lastname: Rawat
authors.forename: Anil
authors.initials: A
authors.lastname: Kumar
authors.forename: Rita
authors.initials: R
authors.lastname: Kumar
authors.forename: Santosh
authors.initials: S
authors.lastname: Pasha
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D010455:Peptides / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D010455:Peptides