Influence of maternal lipid profile on placental protein expression of LDLr and SR-BI.
Maternal hyperlipidemia is a characteristic feature during pregnancy, it has been reported that modification of the maternal lipid profile can induce disturbance during pregnancy. In this study, we evaluated the impact of maternal lipid profile on the placental protein expression of two major receptors in cholesterol metabolism, the low density lipoprotein receptor (LDLr) and the scavenger receptor type B1 (SR-B1). We demonstrate an increase in the level of maternal total circulating cholesterol leads to a significant decrease in the level of the LDLr protein expression, while the level of the SR-BI expression remains unchanged. A similar change, for LDLr, is observed in association with the maternal pre-pregnancy body mass index and weight gain. Our data suggest that the LDLr plays a role in regulating cholesterol delivered to the baby from the placenta.
Ethier-Chiasson
M
M
Laboratoire de Physiologie Materno-Foetale, Département des Sciences Biologiques, Université du Québec à Montréal, C.P. 8888, Succursale Centre-ville, Montréal, Que., Canada H3C 3P8.
Duchesne
A
A
Forest
J-C
JC
Giguère
Y
Y
Masse
A
A
Mounier
C
C
Lafond
J
J
D000328:Adult; D015992:Body Mass Index; D005260:Female; D015870:Gene Expression / Q000502:physiology; D006801:Humans; D050356:Lipid Metabolism / Q000502:physiology*; D008431:Maternal-Fetal Exchange / Q000502:physiology*; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy; D011973:Receptors, LDL / Q000378:metabolism*; D051122:Scavenger Receptors, Class B / Q000378:metabolism*
D011973:Receptors, LDL; C495124:SCARB1 protein, human; D051122:Scavenger Receptors, Class B