Isothiocyanato-calix[4]phyrin-(1,1,1,1): a useful intermediate for the synthesis of derivatised anion sensors.
A calix[4]phyrin-(1,1,1,1) substituted with a 4-isothiocyanatophenyl group has been synthesised and used to attach the macrocycle to a solid support. The NCS group can also be used to further functionalise the calix[4]phyrin-(1,1,1,1) by reaction with amines and amino acids. Stability constants for anion binding by the calix[4]phyrin-(1,1,1,1) are reported and these show a clear ability to differentiate F(-) and HSO(4)(-) from Cl(-), Br(-), I(-) which can be detected by both NMR and UV-visible spectroscopy.
Jha
Sushil C
SC
Department of Chemistry, University of Hull, Kingston-upon-Hull, E. Yorks, UK.
Lorch
Mark
M
Lewis
Robert A
RA
Archibald
Stephen J
SJ
Boyle
Ross W
RW