Deregulated over expression of FOXP1 protein in diffuse large B-cell lymphoma does not occur as a result of gene rearrangement.
Strong uniform expression of FOXP1 protein occurs in a subgroup of non-germinal centre (GC) diffuse large B-cell lymphomas (DLBCL). We have investigated gene rearrangement as a potential mechanism for deregulated expression of FOXP1 however, using FISH FOXP1 translocations were not found in any case with over-expression of the protein.
Barrans
Sharon L
SL
Fenton
James A L
JA
Ventura
Roland
R
Smith
Alex
A
Banham
Alison H
AH
Jack
Andrew S
AS
D051858:Forkhead Transcription Factors / Q000032:analysis / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic; D015321:Gene Rearrangement; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D016393:Lymphoma, B-Cell / Q000235:genetics; D016403:Lymphoma, Large B-Cell, Diffuse / Q000235:genetics*; D012097:Repressor Proteins / Q000032:analysis / Q000235:genetics*
C486626:FOXP1 protein, human; D051858:Forkhead Transcription Factors; D012097:Repressor Proteins