Signal transduction pathways of calcitonin/calcitonin receptor regulating cytoskeletal organization and bone-resorbing activity of osteoclasts.
Calcitonin is a calcium-regulating peptide hormone that acts directly on osteoclasts and suppresses their function. In this review we will focus on the downstream signaling pathways of calcitonin receptor regulating cytoskeletal organization of osteoclasts. We will also introduce the clinical application of the hormone for metabolic bone diseases.
Tanaka
S
S
Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo, Japan. tanakas-ort@h.u-tokyo.ac.jp
Suzuki
H
H
Yamauchi
H
H
Nakamura
I
I
Nakamura
K
K
D000818:Animals; D001862:Bone Resorption / Q000378:metabolism*; D002116:Calcitonin / Q000378:metabolism*; D003599:Cytoskeleton / Q000502:physiology*; D010010:Osteoclasts / Q000502:physiology*; D018003:Receptors, Calcitonin / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*
D018003:Receptors, Calcitonin; D002116:Calcitonin