title: Gender influence on the diagnostic accuracy of 64-slice multislice computed tomography coronary angiography for detection of obstructive coronary artery disease.
abstract: OBJECTIVE
  To compare the diagnostic accuracy of 64-slice multislice computed tomography (MSCT) coronary angiography between female and male patients using conventional coronary angiography as the reference standard.
  
  
  METHODS
  Diagnostic accuracy study.
  
  
  METHODS
  University hospital.
  
  
  METHODS
  103 consecutive patients (51 men, 52 women, mean (SD) age 60 (10) years) with known and suspected coronary artery disease underwent 64-slice MSCT.
  
  
  METHODS
  Diagnostic accuracy of 64-slice MSCT to detect obstructive (>or=50% luminal narrowing) stenoses in men and women.
  
  
  RESULTS
  One male and two female patients were excluded from the analysis owing to non-diagnostic MSCT scans as a result of increased heart rate and breathing during the scan. Accordingly, on segmental level, 728/762 coronary segments were of sufficient quality in women (96% (95% CI 95% to 97%)) and 704/723 segments were interpretable in men (97% (95% CI 96% to 98%)). In the remaining 100 patients included in the further analyses, the sensitivity and specificity on a segmental level in women and men were 85% (95% CI 75% to 95%) vs 85% (95% CI 78% to 92%) and 99% (95% CI 98% to 100%) vs 99% (95% CI 98% to 100%), respectively. On a patient level, the sensitivity in women and men was 95% (95% CI 87% to 100%) vs 100%, specificity 93% (95% CI 83% to 100%) vs 89% (95% CI 74% to 100%), positive predictive value 91% (95% CI 79% to 100%) vs 94% (95% CI 86% to 100%), and negative predictive value 96% (95% CI 89% to 100%) vs 100%, respectively.
  
  
  CONCLUSIONS
  The findings confirm the high diagnostic accuracy of 64-slice MSCT coronary angiography in both male and female patients.
authors.affiliation: Department of Cardiology, Leiden University Medical Centre, Leiden, The Netherlands.
authors.forename: G
authors.initials: G
authors.lastname: Pundziute
authors.forename: J D
authors.initials: JD
authors.lastname: Schuijf
authors.forename: J W
authors.initials: JW
authors.lastname: Jukema
authors.forename: J M
authors.initials: JM
authors.lastname: van Werkhoven
authors.forename: E
authors.initials: E
authors.lastname: Boersma
authors.forename: A
authors.initials: A
authors.lastname: de Roos
authors.forename: E E
authors.initials: EE
authors.lastname: van der Wall
authors.forename: J J
authors.initials: JJ
authors.lastname: Bax
mesh_terms: D017023:Coronary Angiography / Q000379:methods*; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012737:Sex Factors; D014057:Tomography, X-Ray Computed / Q000379:methods*