Autoimmune pancreatitis.
Autoimmune pancreatitis (AIP) is a benign, IgG4-related, fibroinflammatory form of chronic pancreatitis that can mimic pancreatic ductal adenocarcinoma both clinically and radiographically. Laboratory studies typically demonstrate elevated serum IgG4 levels and imaging studies reveal a diffusely or focally enlarged pancreas with associated diffuse or focal narrowing of the pancreatic duct. The pathologic features include periductal lymphoplasmacytic inflammation, obliterative phlebitis, and abundant IgG4-positive plasma cells. The treatment of choice for AIP is steroid therapy. Diagnostic criteria for AIP have been proposed that incorporate histologic, radiographic, serologic, and clinical information.
Krasinskas
Alyssa M
AM
Department of Pathology, University of Pittsburgh, UPMC - Presbyterian, 200 Lothrop Street, A610, Pittsburgh, PA 15213, USA. krasinskasam@upmc.edu
Raina
Amit
A
Khalid
Asif
A
Tublin
Mitchell
M
Yadav
Dhiraj
D
D000888:Antibodies, Anti-Idiotypic / Q000276:immunology*; D001327:Autoimmune Diseases / Q000175:diagnosis / Q000276:immunology / Q000628:therapy; D002760:Cholangiopancreatography, Endoscopic Retrograde / Q000379:methods*; D049448:Cholangiopancreatography, Magnetic Resonance; D003937:Diagnosis, Differential; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D010195:Pancreatitis / Q000175:diagnosis / Q000276:immunology / Q000628:therapy; D011379:Prognosis; D014057:Tomography, X-Ray Computed
D000888:Antibodies, Anti-Idiotypic; D005938:Glucocorticoids; D007074:Immunoglobulin G