title: Characterization of NcsB2 as a promiscuous naphthoic acid/coenzyme A ligase integral to the biosynthesis of the enediyne antitumor antibiotic neocarzinostatin.
authors.affiliation: Department of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, Massachusetts 02467, USA.
authors.forename: Heather A
authors.initials: HA
authors.lastname: Cooke
authors.forename: Jian
authors.initials: J
authors.lastname: Zhang
authors.forename: Meghan A
authors.initials: MA
authors.lastname: Griffin
authors.forename: Koichi
authors.initials: K
authors.lastname: Nonaka
authors.forename: Steven G
authors.initials: SG
authors.lastname: Van Lanen
authors.forename: Ben
authors.initials: B
authors.lastname: Shen
authors.forename: Steven D
authors.initials: SD
authors.lastname: Bruner
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis*; D001426:Bacterial Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D002264:Carboxylic Acids / Q000737:chemistry / Q000378:metabolism*; D003065:Coenzyme A / Q000378:metabolism*; D015964:Gene Expression Regulation, Bacterial; D015394:Molecular Structure; D005810:Multigene Family; D009281:Naphthalenes / Q000737:chemistry / Q000378:metabolism*; D013302:Streptomyces / Q000201:enzymology; D009353:Zinostatin / Q000096:biosynthesis*
chemical_list: D000903:Antibiotics, Antineoplastic; D001426:Bacterial Proteins; D002264:Carboxylic Acids; D009281:Naphthalenes; C085312:1-naphthoic acid; D009353:Zinostatin; D003065:Coenzyme A