title: Formal chemoselective synthesis of leucascandrolide A.
abstract: A chemoselective synthesis of the macrocyclic core of leucascandrolide A has been achieved, utilizing highly enantioselective allylmetalations, an enantioselective Noyori reduction of a propargylic ketone and olefin metatheses as the key steps.
authors.affiliation: Laboratoire de Chimie Organique, ESPCI, CNRS, 10 Rue Vauquelin, 75231 Paris Cedex 05, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Ferrié
authors.forename: Sébastien
authors.initials: S
authors.lastname: Reymond
authors.forename: Patrice
authors.initials: P
authors.lastname: Capdevielle
authors.forename: Janine
authors.initials: J
authors.lastname: Cossy
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry; D012717:Sesquiterpenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism
chemical_list: D000935:Antifungal Agents; D000970:Antineoplastic Agents; D012717:Sesquiterpenes; C408748:leucascandrolide A