title: Effect of oral D-penicillamine vs. colchicine on experimentally induced peritoneal adhesions in rats.
abstract: OBJECTIVE
  To evaluate the effects of d-penicillamine on prevention or reduction of adhesion band formation and to compare its effects with those of colchicine in an animal model.
  
  
  METHODS
  A prospective experimental study.
  
  
  METHODS
  Rats in an academic research environment.
  
  
  METHODS
  Eighty female rats were randomly divided into four equal groups. In the end, group 4 was excluded because of high mortality rates.
  
  
  METHODS
  Adhesion bands were induced by intraperitoneal injection of 2.5 mL of a 10% sterile talc solution. The first group served as control, group 2 received oral D-penicillamine (35 mg/kg per day), group 3 received oral colchicines (0.02 mg/kg per day), and group 4 received both drugs for 3 consecutive weeks.
  
  
  METHODS
  Formation of adhesion bands was quantitatively graded according to the Nair classification.
  
  
  RESULTS
  The proportion of control rats with substantial adhesion bands was significantly higher than that of rats in groups 2 or 3 (84.2%, 20%, and 33.3%). No difference regarding the grades of adhesion bands was found between the D-penicillamine and colchicine groups.
  
  
  CONCLUSIONS
  Oral D-penicillamine is as effective as oral colchicine in prevention of peritoneal adhesion band formation in rats. Use of D-penicillamine for this purpose should be weighed against its possible side effects.
authors.affiliation: Shiraz Organ Transplantation Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran. transpln@sums.ac.ir
authors.forename: Saman
authors.initials: S
authors.lastname: Nikeghbalian
authors.forename: Sohrab
authors.initials: S
authors.lastname: Atefi
authors.forename: Kourosh
authors.initials: K
authors.lastname: Kazemi
authors.forename: Naghmeh
authors.initials: N
authors.lastname: Roshan
authors.forename: Nader
authors.initials: N
authors.lastname: Tanideh
authors.forename: Hamed
authors.initials: H
authors.lastname: Jalaeian
mesh_terms: D000284:Administration, Oral; D000818:Animals; D003078:Colchicine / Q000008:administration & dosage*; D005260:Female; D010396:Penicillamine / Q000008:administration & dosage*; D010537:Peritoneum / Q000187:drug effects* / Q000473:pathology; D011446:Prospective Studies; D051381:Rats; D000267:Tissue Adhesions / Q000473:pathology / Q000517:prevention & control*
chemical_list: D010396:Penicillamine; D003078:Colchicine