title: Esophageal involvement in microscopic polyangiitis: a case report and review of literature.
abstract: A 72-year-old man with cough and sputum showed esophageal wall thickening and pneumonia in chest computed tomography (CT) scan. Following endoscopy, we diagnosed reflux esophagitis and subscribed proton pump inhibitor. The esophageal lesion, however, was intractable. We diagnosed microscopic polyangiitis (MPA) because of vasculitis symptoms, cytoplasmic antineutrophil cytoplasmic antibodies (cANCA) in blood and no granulomatous change in the esophagus. We adopted pulse therapy of cyclophosphamide and oral prednisolone; the symptoms and esophageal lesion were markedly improved. We concluded that the esophageal lesion was an aspect of MPA. To our knowledge, this is the first report of esophageal involvement in MPA.
authors.affiliation: Department of Gastroenterology & Hepatology, Kitano Hospital, Osaka, Japan. ma-matsumoto@kitano-hp.or.jp
authors.forename: Masataka
authors.initials: M
authors.lastname: Matsumoto
authors.forename: Takefumi
authors.initials: T
authors.lastname: Nakamura
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Ohashi
authors.forename: Tomoko
authors.initials: T
authors.lastname: Okuno
authors.forename: Kosho
authors.initials: K
authors.lastname: Takasu
authors.forename: Shouichi
authors.initials: S
authors.lastname: Hoshino
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Sugiura
authors.forename: Dan
authors.initials: D
authors.lastname: Ueshima
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Suzuki
authors.forename: Suguru
authors.initials: S
authors.lastname: Uose
authors.forename: Takayuki
authors.initials: T
authors.lastname: Nada
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Kawaguchi
mesh_terms: D000368:Aged; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood*; D003520:Cyclophosphamide / Q000627:therapeutic use; D003937:Diagnosis, Differential; D004941:Esophagitis / Q000209:etiology* / Q000473:pathology* / Q000628:therapy; D014890:Granulomatosis with Polyangiitis / Q000175:diagnosis / Q000473:pathology*; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D010951:Plasma Exchange; D010488:Polyarteritis Nodosa / Q000150:complications* / Q000473:pathology* / Q000628:therapy; D011239:Prednisolone / Q000627:therapeutic use
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D016756:Immunoglobulins, Intravenous; D007166:Immunosuppressive Agents; D003520:Cyclophosphamide; D011239:Prednisolone