[Comparison of transdermal permeation in vitro of lidocaine tincture and microemulsion].
OBJECTIVE
To compare lidocaine tincture and microemulsion for their transdermal permeation.


METHODS
The experimental model for percutaneous administration of lidocaine preparations in vitro was prepared using modified Franz diffusion cell.


RESULTS
The accumulated infiltration amount of lidocaine microemulsion in unit area was higher than that in its cream or tincture preparations.


CONCLUSIONS
The transdermal permeation of lidocaine microemulsion in vitro can be more efficient than that of the tincture preparation, and the permeation is linearly dependent on the dose administered within a certain range.
Huang
Liang
L
Institute of Pharmaceutical Sciences, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. huangl@ fimmu.com
Chen
Zhi-liang
ZL
Li
Guo-feng
GF
Zhu
Xiao-liang
XL
Liu
Chan
C
D000279:Administration, Cutaneous; D000779:Anesthetics, Local / Q000008:administration & dosage*; D004339:Drug Compounding; D016503:Drug Delivery Systems; D004655:Emulsions / Q000008:administration & dosage*; D008012:Lidocaine / Q000008:administration & dosage*; D012869:Skin Absorption
D000779:Anesthetics, Local; D004655:Emulsions; D008012:Lidocaine