title: Evolution of a focal brain lesion produced by interlaced microplanar X-rays.
abstract: Stereotactic radiosurgery has led to advances in the treatment of central nervous system disease. It relies upon the principle of delivering relatively high dose irradiation to a precise target, while exposing surrounding tissues to extremely low doses. We describe a novel radiosurgical approach using interlaced microplanar X-rays which we have termed "microradiosurgery." The use of microbeams allows for 1,000-times greater precision than current clinically employed techniques. As a demonstration of this new method, we produced a approximately 3.8 mm (3) lesion in the rat brain. The lesion was followed over a period of 216 days using 9.4 Tesla magnetic resonance imaging. Our results show a gradually developing lesion at the site of the interlaced beams. The lesion began as a high T2 signal only, but advanced to include a central area of low T1 and mixed T2 signal within 2 months. No lesion was observed in the other side of the brain which was exposed to non-interlaced microbeams only. Interlaced microbeams is an effective method to create focal brain microlesions. This technique may allow the future treatment of pathology not accessible by surgical or more traditional radiosurgical means.
authors.affiliation: Medical Department, Brookhaven National Laboratory, Upton, NY, USA. danschel@bnl.gov
authors.forename: D J
authors.initials: DJ
authors.lastname: Anschel
authors.forename: P
authors.initials: P
authors.lastname: Romanelli
authors.forename: H
authors.initials: H
authors.lastname: Benveniste
authors.forename: B
authors.initials: B
authors.lastname: Foerster
authors.forename: J
authors.initials: J
authors.lastname: Kalef-Ezra
authors.forename: Z
authors.initials: Z
authors.lastname: Zhong
authors.forename: F A
authors.initials: FA
authors.lastname: Dilmanian
mesh_terms: D000818:Animals; D001921:Brain / Q000473:pathology* / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D008279:Magnetic Resonance Imaging; D008297:Male; D011833:Radiation Injuries, Experimental / Q000209:etiology* / Q000473:pathology; D016634:Radiosurgery / Q000009:adverse effects* / Q000379:methods; D051381:Rats; D011916:Rats, Inbred F344