Modelling urinary excretion of molybdenum after oral and intravenous administration of stable tracers.
An extensive study using stable isotopes of molybdenum as tracers was undertaken to investigate intestinal uptake, systemic kinetics and urinary excretion of molybdenum in healthy human volunteers. In total 63 experiments with 17 volunteers were performed administering the tracers in different chemical forms and measuring their concentrations in blood plasma and urine samples by means of activation analysis and mass spectrometry. Molybdenum was eliminated very rapidly from the circulation. The amount eliminated via the renal pathway was observed to be dependent on several factors, such as form and modality of administration and also the total amount of circulating molybdenum. The fact that the urinary excretion patterns diverged significantly from the current predictions of the International Commission on Radiological Protection model might be relevant when using the model for retrospective intake assessments in case of an accident. On the basis of the experimental data, a more realistic compartmental structure has been presented.
Giussani
Augusto
A
Dipartimento di Fisica, Università degli Studi di Milano, and INFN, Sezione di Milano, via Celoria 16, 20133 Milano, Italy. augusto.giussani@unimi.it
Cantone
Marie Claire
MC
Höllriegl
Vera
V
Oeh
Uwe
U
Tavola
Federico
F
Veronese
Ivan
I
D000284:Administration, Oral; D000328:Adult; D001681:Biological Assay / Q000379:methods*; D003198:Computer Simulation; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D008982:Molybdenum / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000652:urine*; D011829:Radiation Dosage; D011874:Radiometry / Q000379:methods*; D012680:Sensitivity and Specificity; D016482:Urinalysis / Q000379:methods*
D008982:Molybdenum