Site-selective depurination by a periodate-dependent deoxyribozyme.
A deoxyribozyme is identified that mediates the site-selective depurination of its 5'-terminal guanosine nucleotide using periodate (IO(4)-) as an obligatory cofactor.
Höbartner
Claudia
C
Department of Chemistry, University of Illinois at Urbana-Champaign, 600 South Mathews Avenue, Urbana, Illinois 61801, USA.
Pradeepkumar
P I
PI
Silverman
Scott K
SK
D000586:Amination; D021881:DNA, Catalytic / Q000737:chemistry*; D006151:Guanosine / Q000031:analogs & derivatives; D008956:Models, Chemical; D009841:Oligonucleotides / Q000737:chemistry; D010504:Periodic Acid / Q000737:chemistry*; D011687:Purines / Q000737:chemistry*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
D021881:DNA, Catalytic; D009841:Oligonucleotides; D011687:Purines; D010504:Periodic Acid; D006151:Guanosine