Dexamethasone transiently attenuates up-regulation of endostatin/collagen XVIII following traumatic brain injury.
Endostatin/collagen XVIII is a specific inhibitor of endothelial proliferation and migration in vitro. It has also been shown to have anti-angiogenic activity and tumor growth inhibitory activity in vivo and in vitro. Here we studied expression of endostatin/collagen XVIII in a rat traumatic brain injury (TBI) model, focusing on the early phase. A significant up-regulation of endostatin/collagen XVIII in TBI began as early as 24 h post-TBI. Double-staining experiment revealed that the major resource of endostatin/collagen XVIII(+) cells in our TBI rat model was a subpopulation of reactivated microglia/macrophages. Our data further showed that dexamethasone attenuated up-regulation of endostatin/collagen XVIII expression at days 1 and 2, but not at day 4, post-TBI, indicating that dexamethasone might possess an early and transient influence to the angiogenesis following TBI.
Zhang
Z-Y
ZY
Institute of Brain Research, University of Tuebingen, Tuebingen, Germany.
Zhang
Z
Z
Fauser
U
U
Artelt
M
M
Burnet
M
M
Schluesener
H J
HJ
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D001930:Brain Injuries / Q000188:drug therapy* / Q000378:metabolism; D002452:Cell Count; D003094:Collagen / Q000378:metabolism*; D003907:Dexamethasone / Q000008:administration & dosage*; D043169:Endostatins / Q000378:metabolism*; D008297:Male; D051381:Rats; D011917:Rats, Inbred Lew; D013997:Time Factors; D015854:Up-Regulation / Q000187:drug effects*
D000893:Anti-Inflammatory Agents; C475584:Col23a1 protein, rat; D043169:Endostatins; D003907:Dexamethasone; D003094:Collagen