title: LASIK and dry eye.
abstract: Dry eye is one of the most common complications after laser-assisted in situ keratomileusis (LASIK). The clinical signs of post-LASIK dry eye include positive vital staining of ocular surface, decreased tear film breakup time and Schirmer test, reduced corneal sensitivity, and decreased functional visual acuity. The symptoms and signs last at least 1 month after LASIK. Although the mechanisms for developing post-LASIK dry eye are not completely understood, loss of corneal innervation by flap-making may affect the reflex loops of the corneal-lacrimal gland, corneal-blinking, and blinking-meibomian gland, and blinking-meibomian gland, resulting in decreased aqueous and lipid tear secretion and mucin expression. As LASIK enhancement by flap-lifting induces less dry eye symptoms and signs than first surgery, it is suggested that other factors rather than loss of neurotrophic effect may be involved in the mechanisms of post-LASIK dry eye. The treatments of dry eye include artificial tears, topical cyclosporine, hot compress, punctal plugs, and autologous serum eye drops. For patients with severe preoperative dry eye, a combination of punctal plugs and serum eye drops is required to be used before surgery.
authors.affiliation: Minamiaoyama Eye Clinic, Tokyo, Japan. ikuko@tka.att.ne.jp
authors.forename: Ikuko
authors.initials: I
authors.lastname: Toda
mesh_terms: D016572:Cyclosporine / Q000008:administration & dosage / Q000627:therapeutic use; D015352:Dry Eye Syndromes / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D020731:Keratomileusis, Laser In Situ / Q000009:adverse effects* / Q000379:methods; D009779:Occlusive Dressings; D009824:Ointments / Q000627:therapeutic use; D009883:Ophthalmic Solutions / Q000627:therapeutic use; D019736:Prostheses and Implants; D013524:Surgical Flaps / Q000009:adverse effects; D013997:Time Factors; D014792:Visual Acuity
chemical_list: D009824:Ointments; D009883:Ophthalmic Solutions; D016572:Cyclosporine