title: A randomized trial of smoking cessation. Medication versus motivation.
abstract: OBJECTIVE
  A prospective randomized study was undertaken to assess the effectiveness and side effect profiles of nicotine patch and bupropion therapies for smoking cessation.
  
  
  METHODS
  Three hundred and fifty patients were referred to our smoking cessation program in the Department of Pulmonary Diseases, Gaziantep University between September 2002 and July 2003. Of these, only 131 patients fulfilled the trial criteria. We randomized the patients into nicotine patch (n=50), bupropion (n=50) and control groups (n=31). Cases were followed up for 24 weeks. Questionnaires including the Fagerstrom test for nicotine dependence and Beck Depression Inventory were carried out at initial evaluation. Declaration of quitting and exhaled carbon monoxide level less than 10 ppm was accepted as success criteria.
  
  
  RESULTS
  Success rates were 26% for nicotine patch group, 26% for bupropion and 16% for control group at the end of the 24th week (p=0.56). Beck depression inventory scores did not differ significantly between the groups, however none of the cases with scores greater than 13 succeeded regardless of the group. Mean body weight at baseline and change at 6 months did not differ significantly between the groups. Sleep disturbance was significantly more common in nicotine patch and bupropion groups than the control group (p=0.008).
  
  
  CONCLUSIONS
  The present study reinforces the role of medical doctors and importance of close follow up in smoking cessation, and directed counseling is quite as effective as pharmacologic therapy and is the sole approach without any adverse effects.
authors.affiliation: Department of Pulmonary Diseases, Gaziantep University, Gaziantep 27035, Turkey. meraluyar1@yahoo.com
authors.forename: Meral
authors.initials: M
authors.lastname: Uyar
authors.forename: Ayten
authors.initials: A
authors.lastname: Filiz
authors.forename: Nazan
authors.initials: N
authors.lastname: Bayram
authors.forename: Osman
authors.initials: O
authors.lastname: Elbek
authors.forename: Hasan
authors.initials: H
authors.lastname: Herken
authors.forename: Ayfer
authors.initials: A
authors.lastname: Topcu
authors.forename: Oner
authors.initials: O
authors.lastname: Dikensoy
authors.forename: Erhan
authors.initials: E
authors.lastname: Ekinci
mesh_terms: D000328:Adult; D016642:Bupropion / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D009042:Motivation; D009538:Nicotine / Q000008:administration & dosage*; D011446:Prospective Studies; D016540:Smoking Cessation / Q000379:methods* / Q000523:psychology
chemical_list: D016642:Bupropion; D009538:Nicotine