title: Sulci density map to aid in use of apparent diffusion coefficient for therapy evaluation.
abstract: In order to more accurately asses variations in the apparent diffusion coefficient used for therapy evaluation, we have studied the variation in sulci density in the human brain. Sagittal, axial and coronal magnetic resonance imaging scans have been analyzed to determine the change of the coefficient of variance of pixel intensity as a function of position. In the sagittal direction, relative to the 50% most medial slices, we find an 11.0%+/-4.8% (S.D.) decrease in the next 25% (12.5% on each side) of the slices. The most lateral 25% of the slices had less of a decrease and more variation: 7.0%+/-12.2%. Similar variations were observed in axial and coronal scans.
authors.affiliation: Department of Radiation Oncology, University of Arizona, Tucson, AZ 85724-5175, USA. lewell@email.arizona.edu
authors.forename: Lars A
authors.initials: LA
authors.lastname: Ewell
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Watchman
authors.forename: Kurt
authors.initials: K
authors.lastname: Wharton
mesh_terms: D001931:Brain Mapping / Q000379:methods*; D001932:Brain Neoplasms / Q000532:radiotherapy; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D018787:Radiation Oncology / Q000379:methods