Fusaristatins A and B, two new cyclic lipopeptides from an endophytic Fusarium sp.
Two new cyclic lipopeptides, fusaristatins A (1) and B (2) were isolated from rice cultures of a Fusarium sp. YG-45 in the course of a screening of endophytic fungi. Their structures of 1 and 2 were determined by spectroscopic methods. 2 showed a moderate inhibitory effect on topoisomerases I (IC50: 73 microM) and II (IC50: 98 microM) without cleavable complexes. Furthermore, 1 and 2 showed the growth-inhibitory activity toward lung cancer cells LU 65 with IC50 values of 23 and 7 microM, respectively.
Shiono
Yoshihito
Y
Department of Bioresource Engineering, Faculty of Agriculture, Yamagata University, Japan. yshiono@tds1.tr.yamagata-u.ac.jp
Tsuchinari
Mio
M
Shimanuki
Keiko
K
Miyajima
Takeshi
T
Murayama
Tetsuya
T
Koseki
Takuya
T
Laatsch
Hartmut
H
Funakoshi
Takayuki
T
Takanami
Koji
K
Suzuki
Keitarou
K
D000903:Antibiotics, Antineoplastic / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D003470:Culture Media; D047630:Depsipeptides / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005285:Fermentation; D005658:Fungi / Q000187:drug effects; D005670:Fusarium / Q000737:chemistry*; D006801:Humans; D029901:Maackia / Q000382:microbiology; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D059004:Topoisomerase I Inhibitors; D059005:Topoisomerase II Inhibitors
D000903:Antibiotics, Antineoplastic; D003470:Culture Media; D047630:Depsipeptides; D004791:Enzyme Inhibitors; D059004:Topoisomerase I Inhibitors; D059005:Topoisomerase II Inhibitors; C522435:fusaristatin A; C522436:fusaristatin B