title: Does troncular vagotomy modify the proliferative gastric lesions induced in rats by duodenogastric reflux?
abstract: OBJECTIVE
  to investigate if combining VT to DGR through the pylorus can modulate the biological behavior of PL induced by DGR and to verify if TV alone can induce morphologic lesions in the gastric mucosa.
  
  
  METHODS
  62 male Wistar rats were assigned to four groups: 1 - Control (CT) gastrotomy; 2 - Troncular Vagotomy (TV) plus gastrotomy; 3 - Duodenogastric reflux through the pylorus (R) and 4 - Troncular vagotomy plus DGR (RTV). The animals were killed at the 54 week of the experiment. DGR was obtained by anastomosing a proximal jejunal loop to the anterior gastric wall. TV was performed through isolation and division of the vagal trunks. Gastrotomy consisted of 1 cm incision at the anterior gastric wall. PL were analyzed gross and histologically in the antral mucosa, at the gastrojejunal stoma and at the squamous portion of the gastric mucosa.
  
  
  RESULTS
  Groups R and RTV developed exophytic lesions in the antral mucosa (R=90.9%; RTV=100%) and at the gastrojejunal stoma (R=54.54%; RTV=63.63%). Histologically they consisted of proliferative benign lesions, without cellular atypias, diagnosed as adenomatous hyperplasia. Both groups exposed to DGR presented squamous hyperplasia at the squamous portion of the gastric mucosa (R= 54.5%; RTV= 45.4%). TV, alone, did not induce gross or histological alterations in the gastric mucosa. TV did note change the morphologic pattern of the proliferative lesions induced by DGR.
  
  
  CONCLUSIONS
  DGR induces the development of PL in the pyloric mucosa and at the gastrojejunal stoma. TV does not change the morphologic pattern of the proliferative lesions induced by DGR. TV alone is not able to induce morphologic lesions in the gastric mucosa.
authors.affiliation: Department of Surgery & Orthopedics, Botucatu Medical School, UNESP, Brazil. paulor@fmb.unesp.br
authors.forename: Paulo Antônio
authors.initials: PA
authors.lastname: Rodrigues
authors.forename: Shoiti
authors.initials: S
authors.lastname: Kobayasi
authors.forename: Maria Aparecida Marchesan
authors.initials: MA
authors.lastname: Rodrigues
mesh_terms: D000230:Adenocarcinoma / Q000209:etiology / Q000473:pathology; D000714:Anastomosis, Surgical; D000818:Animals; D004195:Disease Models, Animal; D004383:Duodenogastric Reflux / Q000150:complications / Q000473:pathology* / Q000601:surgery; D005753:Gastric Mucosa / Q000473:pathology*; D005774:Gastrostomy; D006801:Humans; D006965:Hyperplasia; D007583:Jejunum / Q000473:pathology / Q000601:surgery; D008297:Male; D011708:Pylorus / Q000473:pathology / Q000601:surgery; D051381:Rats; D017208:Rats, Wistar; D013270:Stomach / Q000473:pathology*; D013274:Stomach Neoplasms / Q000209:etiology / Q000473:pathology; D015167:Vagotomy, Truncal