Cardiac myosin-binding protein C in the heart.
Understanding the structural and functional role of cardiac myosin-binding protein C in the heart is clinically relevant, as cMyBP-C gene mutations are a widely recognized cause of familial hypertrophic cardiomyopathy. Our knowledge about this protein considerably improved over the past decade. This review outlines several studies, which highlight the role of cardiac myosin-binding protein C and its phosphorylation in the heart in health and disease. Arch
Carrier
Lucie
L
Institute of Experimental and Clinical Pharmacology and Toxicology, University Medical Centre Hamburg-Eppendorf, D-20246 Hamburg, Germany. l.carrier@uke.uni-hamburg.de
D002312:Cardiomyopathy, Hypertrophic / Q000235:genetics; D002352:Carrier Proteins / Q000235:genetics / Q000502:physiology* / Q000648:ultrastructure; D006321:Heart / Q000502:physiology*; D006801:Humans; D009154:Mutation / Q000235:genetics; D009206:Myocardium / Q000737:chemistry; D009218:Myosins / Q000235:genetics / Q000502:physiology* / Q000648:ultrastructure; D010766:Phosphorylation; D000099163:Myosin Binding Protein C
D002352:Carrier Proteins; D009218:Myosins; D000099163:Myosin Binding Protein C