title: Vasorelaxant effects of Acer nikoense extract and isolated coumarinolignans on rat aortic rings.
abstract: The organic extract of the heartwood of Acer nikoense Maxim. (Aceraceae) showed vasorelaxant activity on rat aorta with or without endothelium. Coumarin [scopoletin (1)] and coumarinolignans [cleomiscosin A (2) and aquillochin (3)] were isolated as major constituents from the organic extract of the heartwood of A. nikoense. Compounds 1-3 exhibited moderate vasorelaxant effects on rat aorta, while 2 and 3 showed vasorelaxant effects in the norepinephrine-stimulated and also in high K+-depolarized preparations.
authors.affiliation: Faculty of Pharmaceutical Sciences, Hoshi University, Tokyo, Japan. t.iizuka@hamayaku.ac.jp
authors.forename: Toru
authors.initials: T
authors.lastname: Iizuka
authors.forename: Seiji
authors.initials: S
authors.lastname: Nagumo
authors.forename: Hideomi
authors.initials: H
authors.lastname: Yotsumoto
authors.forename: Hiroyoshi
authors.initials: H
authors.lastname: Moriyama
authors.forename: Masahiro
authors.initials: M
authors.lastname: Nagai
mesh_terms: D031002:Acer / Q000737:chemistry*; D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects* / Q000601:surgery; D004305:Dose-Response Relationship, Drug; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D008297:Male; D008519:Medicine, Traditional; D015394:Molecular Structure; D009529:Nicardipine / Q000494:pharmacology; D009638:Norepinephrine / Q000494:pharmacology; D010477:Perfusion; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D014662:Vasoconstrictor Agents / Q000494:pharmacology; D014665:Vasodilator Agents / Q000494:pharmacology*
chemical_list: D017705:Lignans; D010936:Plant Extracts; D014662:Vasoconstrictor Agents; D014665:Vasodilator Agents; D009529:Nicardipine; D000109:Acetylcholine; D009638:Norepinephrine