title: Increased use of antidepressants at the end of life: population-based study among people aged 65 years and above.
abstract: BACKGROUND
  The new antidepressants are generally effective and safe for older people, but may have serious side-effects. The use has been rapidly increasing, but focus on upper age groups has been limited. The pattern of antidepressant use as death approaches has never been analysed.
  
  
  OBJECTIVE
  To analyse the use of antidepressants among individuals aged 65 years and above with respect to time trends, age and proximity to death.
  
  
  METHODS
  Population-based prescription study.
  
  
  METHODS
  The County of Funen, Denmark, 1992-2004 (approximately 470,000 inhabitants).
  
  
  RESULTS
  The 1-year prevalence of antidepressants increases steadily over time in all age groups. Among the 65+ year-olds it also increases with age and differs substantially between the youngest and the oldest. Very high prevalences are observed: 26.8% among females 85-89 years old and 17.5% among males 85 years and above in 2004. In all age groups the use of antidepressants increases substantially with proximity to death in the last 3 years of life. In the last phase of life the use is independent of whether the patient dies at age 65 or 90 about 33% of females and 25% of males receive antidepressants in the last 6 months.
  
  
  CONCLUSIONS
  The use of antidepressants among 65+ year-olds increases with age and proximity to death to very high levels. Future studies may clarify the problems and diagnoses giving rise to the use of antidepressants for such a large proportion of older people, and especially the problems giving rise to treatment as death approaches.
authors.affiliation: Research Unit for General Practice, University of Southern Denmark, JB Winsløws Vej 9A, DK-5000 Odense C, Denmark. dgilsaa@health.sdu.dk
authors.forename: Dorte Gilså
authors.initials: DG
authors.lastname: Hansen
authors.forename: Jens-Ulrik
authors.initials: JU
authors.lastname: Rosholm
authors.forename: Anthony
authors.initials: A
authors.lastname: Gichangi
authors.forename: Werner
authors.initials: W
authors.lastname: Vach
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000928:Antidepressive Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001293:Attitude to Death; D003718:Denmark; D003863:Depression / Q000188:drug therapy*; D017723:Drug Utilization Review; D005260:Female; D015577:Geriatric Assessment; D006801:Humans; D008297:Male; D017891:Pharmacoepidemiology; D010818:Practice Patterns, Physicians' / Q000706:statistics & numerical data; D013727:Terminal Care / Q000706:statistics & numerical data*
chemical_list: D000928:Antidepressive Agents