title: Topographic patterns of brain functional impairment progression according to clinical severity staging in 116 Alzheimer disease patients: FDG-PET study.
abstract: The study aimed to explore topographic progression pattern of brain functional impairment according to clinical stage in Alzheimer disease (AD). One hundred and sixteen AD patients and 25 normal subjects underwent a [18F] fluorodeoxyglucose-positron emission tomography scan. Regional cerebral glucose metabolism was compared between severity groups based on the Clinical Dementia Rating through voxel-based analyses. As clinical severity progressed, hypometabolic areas gradually increased, involving initially posterior cingulate cortex, later temporoparietal, and finally frontal and some subcortical areas. The results indicate that progression patterns of hypometabolism in AD are close to that of typical neuropathology, but that they do not fully coincide with it.
authors.affiliation: Department of Neuropsychiatry and Clinical Research Institute, Seoul National University, Seoul, and Department of Neuropsychiatry, Kyunggi Provincial Hospital for the Elderly, Yongin, Korea.
authors.forename: Il Han
authors.initials: IH
authors.lastname: Choo
authors.forename: Dong Young
authors.initials: DY
authors.lastname: Lee
authors.forename: Jong Choul
authors.initials: JC
authors.lastname: Youn
authors.forename: Jin Hyeong
authors.initials: JH
authors.lastname: Jhoo
authors.forename: Ki Woong
authors.initials: KW
authors.lastname: Kim
authors.forename: Dong Soo
authors.initials: DS
authors.lastname: Lee
authors.forename: Jae Sung
authors.initials: JS
authors.lastname: Lee
authors.forename: Jong Inn
authors.initials: JI
authors.lastname: Woo
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology; D001921:Brain / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology; D018450:Disease Progression; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008297:Male; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18