title: Oxime and oxime ether derivatives of 1,4-benzothiazine related to oxiconazole.
abstract: The synthesis, in vitro antifungal activity, and molecular docking experiments of some oxime and oxime ether derivatives of azole 1,4-benzothiazine are reported herein, with the aim of evaluating the influence of a partially constrained scaffold that is structurally related to Oxiconazole and bearing the 1,4-benzothiazine moiety, on the inhibition of Candida albicans CYP51.
authors.affiliation: Dipartimento di Chimica e Tecnologia del Farmaco, Via del Liceo, 1, Università degli Studi di Perugia, 06123 Perugia, Italy.
authors.forename: Lara
authors.initials: L
authors.lastname: Milanese
authors.forename: Nicola
authors.initials: N
authors.lastname: Giacchè
authors.forename: Fausto
authors.initials: F
authors.lastname: Schiaffella
authors.forename: Anna
authors.initials: A
authors.lastname: Vecchiarelli
authors.forename: Antonio
authors.initials: A
authors.lastname: Macchiarulo
authors.forename: Renata
authors.initials: R
authors.lastname: Fringuelli
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry* / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D004987:Ethers; D007093:Imidazoles / Q000737:chemistry* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D010091:Oximes / Q000737:chemistry* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013843:Thiazines / Q000737:chemistry*
chemical_list: C446962:1,4-benzothiazine; D000935:Antifungal Agents; D004987:Ethers; D007093:Imidazoles; D010091:Oximes; D013843:Thiazines; C022155:oxiconazole