[Establishment of an experimental animal model with alveolar bone defect by surgery in rats].
OBJECTIVE
To establish an animal model for experimental study of orthodontic treatment of alveolar bone defect and other relative research.


METHODS
The experiment was carried out on forty SPF female Wistar rats,which were 6 weeks old. With the rats anaesthetized, one side of the alveolar bone in the maxillary first molar of the rats was removed partly. The defects were filled with Bio-glass. The tissue slices from the defects were observed under light microscope 2 weeks after surgery.


RESULTS
Only one of the forty rats was infected after operation, and the survival rate was 97.5%. The wounds of the survived rats healed well, and new bone was found around the Bio-glass 2 weeks after operation.


CONCLUSIONS
Animal model of alveolar bone defect established by surgery is simple and reliable, which can be used for further studies. Supported by National Natural Science Foundation of Shandong Province (Grant No.Y2004C13) and Medical Science and Technology Enhancement Award Project of Shangdong Province (Grant No.2005H2038).
Wang
Xu-xia
XX
Department of Orthodontics, School of Stomatology, Shandong University. Jinan 250012, Shandong Province, China.
Huang
Yan
Y
Zhang
Jun
J
Chen
Dai-yun
DY
D000539:Alveolar Process / Q000473:pathology* / Q000601:surgery*; D000818:Animals; D001672:Biocompatible Materials; D001861:Bone Regeneration; D002516:Ceramics / Q000627:therapeutic use; D005260:Female; D005898:Glass; D023421:Models, Animal; D008963:Molar; D009971:Orthodontics, Corrective; D051381:Rats; D017208:Rats, Wistar
D001672:Biocompatible Materials; C022107:Bioglass