title: In vitro interaction studies of diltiazem with NSAID's using UV spectrophotometry and RP-HPLC techniques.
abstract: Diltiazem (DTZ) is a well-known cardiovascular drug used clinically in the treatment of angina pectoris and hypertension. Present paper deals with the in vitro availability studies of DTZ in presence of commonly used nonsteroidal anti-inflammatory drugs (NSAID's) like diclofenac sodium, flurbiprofen, mefenamic acid and meloxicam. Simultaneous administration of both types of drugs may alter the antihypertensive effect of DTZ. These studies were carried out using BP 2005 dissolution test apparatus in simulated human body environments at body temperature and at elevated temperature in order to study the kinetics and energitics of these interactions. Both the drug in each case were analyzed either by measuring the absorbance of aliquots on a UV/VIS spectrophotometer, or by RP-HPLC method. Present study clearly indicated that most of the NSAID's studied bind to DTZ forming charge transfer complexes, evident from the high availability of DTZ. Hence, concurrent administration of NSAID's with DTZ is not recommended.
authors.affiliation: Research Institute of Pharmaceutical Sciences, Faculty of Pharmacy, University of Karachi, Karachi-75270.
authors.forename: Najma
authors.initials: N
authors.lastname: Sultana
authors.forename: M Saeed
authors.initials: MS
authors.lastname: Arayne
authors.forename: Nighat
authors.initials: N
authors.lastname: Shafi
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry*; D002121:Calcium Channel Blockers / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D004110:Diltiazem / Q000737:chemistry*; D004347:Drug Interactions; D013056:Spectrophotometry, Ultraviolet; D013696:Temperature
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D002121:Calcium Channel Blockers; D004110:Diltiazem