title: Biocompatibility of polylactides in the middle ear: an experimental animal study.
abstract: OBJECTIVE
  To study the suitability of resorbable polylactides for reconstruction in middle ear surgery.
  
  
  METHODS
  Twenty-four chinchillas.
  
  
  METHODS
  Twenty chinchillas were operated on using 2 types of polylactides inserted into the middle ear and outer ear canal, 10 animals in each group. At 6 months, the animals were killed, and their temporal bones were removed for sectioning. Degree of inflammation, fibrosis, degradation of polylactide material, and new bone formation were assessed histologically.
  
  
  METHODS
  Polylactide implants caused only a mild local inflammation, with no difference between the 2 materials tested.
  
  
  CONCLUSIONS
  Polylactide acid-based middle ear implants were successfully used in the reconstructive middle ear surgery. Resorption occurred without complications.
authors.affiliation: Department of Otorhinolaryngology, Helsinki University Central Hospital, Finland.
authors.forename: Lauri I
authors.initials: LI
authors.lastname: Peltonen
authors.forename: Jussi
authors.initials: J
authors.lastname: Jero
authors.forename: Antti
authors.initials: A
authors.lastname: Sukura
authors.forename: Laura
authors.initials: L
authors.lastname: Pietola
authors.forename: Yrjö T
authors.initials: YT
authors.lastname: Konttinen
authors.forename: Antti A
authors.initials: AA
authors.lastname: Aarnisalo
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D002682:Chinchilla; D004432:Ear, Middle / Q000033:anatomy & histology / Q000502:physiology*; D007091:Image Processing, Computer-Assisted; D008297:Male; D008422:Materials Testing; D011091:Polyesters / Q000009:adverse effects*; D019736:Prostheses and Implants; D011817:Rabbits; D013701:Temporal Bone / Q000473:pathology; D016707:Tissue Fixation; D014432:Tympanic Membrane / Q000473:pathology / Q000648:ultrastructure
chemical_list: D001672:Biocompatible Materials; D011091:Polyesters; C033616:poly(lactide)