[Protective effects of lidocaine against lung injury after hemorrhagic shock in rabbits].
OBJECTIVE
To study the protective effect of lidocaine against lung injury after hemorrhagic shock in rabbits.


METHODS
Eighteen healthy rabbits were randomly divided into 3 groups (n=6), namely lidocaine group (group L), hemorrhagic shock group (group H) and control group (group C). Hemorrhagic shock model was established in rabbits in groups L and H, and the venous blood samples were collected for measurement of plasma malondialdehyde (MDA) and superoxidedismutase (SOD) before phlebotomy (T0), 2 h after hemorrhagic shock (T1) and 2 h after resuscitation (T2). Blood samples were also taken for measurement of MDA and SOD at the same time points in group C. The wet to dry weight ratio of the lung (W/D) was measured at T2.


RESULTS
MDA level was significantly lower while SOD level significantly higher in group L than in group H (P<0.05). The W/D ratio in group L was reduced significantly as compared with that in group H (P<0.05).


CONCLUSIONS
Lidocaine can remarkably alleviate lung injury after hemorrhagic shock by inhibiting MDA production and increasing SOD content.
Ruan
Luo-yang
LY
Department of Anesthesiology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. rly25741@ yahoo.com.cn
Lin
Chun-shui
CS
Liu
Ying-ying
YY
Gu
Miao-ning
MN
D000818:Animals; D004195:Disease Models, Animal; D008012:Lidocaine / Q000494:pharmacology*; D008168:Lung / Q000187:drug effects / Q000378:metabolism; D055370:Lung Injury / Q000517:prevention & control*; D008315:Malondialdehyde / Q000097:blood; D011817:Rabbits; D012771:Shock, Hemorrhagic / Q000188:drug therapy*; D013482:Superoxide Dismutase / Q000097:blood
D008315:Malondialdehyde; D008012:Lidocaine; D013482:Superoxide Dismutase