title: Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility.
abstract: A genome-wide association scan in individuals with Crohn's disease by the Wellcome Trust Case Control Consortium detected strong association at four novel loci. We tested 37 SNPs from these and other loci for association in an independent case-control sample. We obtained replication for the autophagy-inducing IRGM gene on chromosome 5q33.1 (replication P = 6.6 x 10(-4), combined P = 2.1 x 10(-10)) and for nine other loci, including NKX2-3, PTPN2 and gene deserts on chromosomes 1q and 5p13.
authors.affiliation: Inflammatory Bowel Disease Research Group, Addenbrooke's Hospital, University of Cambridge, Cambridge CB2 2QQ, UK. miles.parkes@addenbrookes.nhs.uk
authors.forename: Miles
authors.initials: M
authors.lastname: Parkes
authors.forename: Jeffrey C
authors.initials: JC
authors.lastname: Barrett
authors.forename: Natalie J
authors.initials: NJ
authors.lastname: Prescott
authors.forename: Mark
authors.initials: M
authors.lastname: Tremelling
authors.forename: Carl A
authors.initials: CA
authors.lastname: Anderson
authors.forename: Sheila A
authors.initials: SA
authors.lastname: Fisher
authors.forename: Roland G
authors.initials: RG
authors.lastname: Roberts
authors.forename: Elaine R
authors.initials: ER
authors.lastname: Nimmo
authors.forename: Fraser R
authors.initials: FR
authors.lastname: Cummings
authors.forename: Dianne
authors.initials: D
authors.lastname: Soars
authors.forename: Hazel
authors.initials: H
authors.lastname: Drummond
authors.forename: Charlie W
authors.initials: CW
authors.lastname: Lees
authors.forename: Saud A
authors.initials: SA
authors.lastname: Khawaja
authors.forename: Richard
authors.initials: R
authors.lastname: Bagnall
authors.forename: Denis A
authors.initials: DA
authors.lastname: Burke
authors.forename: Catherine E
authors.initials: CE
authors.lastname: Todhunter
authors.forename: Tariq
authors.initials: T
authors.lastname: Ahmad
authors.forename: Clive M
authors.initials: CM
authors.lastname: Onnie
authors.forename: Wendy
authors.initials: W
authors.lastname: McArdle
authors.forename: David
authors.initials: D
authors.lastname: Strachan
authors.forename: Graeme
authors.initials: G
authors.lastname: Bethel
authors.forename: Claire
authors.initials: C
authors.lastname: Bryan
authors.forename: Cathryn M
authors.initials: CM
authors.lastname: Lewis
authors.forename: Panos
authors.initials: P
authors.lastname: Deloukas
authors.forename: Alastair
authors.initials: A
authors.lastname: Forbes
authors.forename: Jeremy
authors.initials: J
authors.lastname: Sanderson
authors.forename: Derek P
authors.initials: DP
authors.lastname: Jewell
authors.forename: Jack
authors.initials: J
authors.lastname: Satsangi
authors.forename: John C
authors.initials: JC
authors.lastname: Mansfield
authors.forename: Lon
authors.initials: L
authors.lastname: Cardon
authors.forename: Christopher G
authors.initials: CG
authors.lastname: Mathew
mesh_terms: D000818:Animals; D001343:Autophagy / Q000235:genetics*; D016022:Case-Control Studies; D003424:Crohn Disease / Q000235:genetics*; D019204:GTP-Binding Proteins / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D006801:Humans; D051379:Mice; D020641:Polymorphism, Single Nucleotide; D017422:Sequence Analysis, DNA
chemical_list: D019204:GTP-Binding Proteins; C513539:IRGM protein, human