title: Acute severe depression induced by intraoperative stimulation of the substantia nigra: a case report.
abstract: We present a 62 years old man with Parkinson's disease (PD) who underwent bilateral stimulation in the subthalamic nucleus (STN). During the intraoperative evaluation, stimulation through the lowest contact in the right STN area, induced an acute depressive state, during which the patient was crying and expressing that he did not want to live. The patient returned to his normal state of mood within seconds after the cessation of stimulation. Repeated blinded stimulations resulted in the same response. Immediate postoperative magnetic resonance imaging (MRI) revealed that the lowest contact of the right electrode was located in the substantia nigra.
authors.affiliation: Department of Neurosurgery, University Hospital of Northern Sweden, Umeå, Sweden. patric.blomstedt@neuro.umu.se
authors.forename: Patric
authors.initials: P
authors.lastname: Blomstedt
authors.forename: Marwan I
authors.initials: MI
authors.lastname: Hariz
authors.forename: Andrew
authors.initials: A
authors.lastname: Lees
authors.forename: Paul
authors.initials: P
authors.lastname: Silberstein
authors.forename: Patricia
authors.initials: P
authors.lastname: Limousin
authors.forename: Jérôme
authors.initials: J
authors.lastname: Yelnik
authors.forename: Yves
authors.initials: Y
authors.lastname: Agid
mesh_terms: D046690:Deep Brain Stimulation / Q000009:adverse effects*; D003863:Depression / Q000209:etiology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000473:pathology / Q000628:therapy; D013378:Substantia Nigra / Q000503:physiopathology / Q000528:radiation effects*