Functional peptides by genome reverse engineering.
Computational biology and chemistry combined with high-throughput analytical technologies contribute to reduce operational costs and foster innovation in every phase of the discovery of bioactive molecules. In order for life science industries to continue to deliver at the required market rate, new concepts need to be implemented in research and development, and new sources of bioactive molecules should be investigated. The genomic revolution provides the necessary information to generate novel bioactive peptides by the computational dissection of genomes.
Grigorov
Martin G
MG
Nestlé Research Center, BioAnalytical Science Department, CH-1000 Lausanne 26, Switzerland. martin.grigorov@rdls.nestle.com
van Bladeren
Peter J
PJ
D019295:Computational Biology; D004059:Diffusion of Innovation; D015195:Drug Design; D053263:Gene Regulatory Networks; D023281:Genomics; D006801:Humans; D010455:Peptides / Q000737:chemistry* / Q000235:genetics; D011487:Protein Conformation; D015202:Protein Engineering; D013329:Structure-Activity Relationship; D013678:Technology, Pharmaceutical / Q000379:methods*
D010455:Peptides