title: Impaired longitudinal myocardial velocities in patients with growth hormone deficiency improves after hormone replacement therapy.
abstract: Cardiac parameters in growth hormone (GH) deficiency and the effects of GH replacement treatment (GHRT) are still controversial. We investigated 19 adult patients (mean age: 45 +/- 10 years, 7 male), with GH deficiency before and after 12 months of GHRT. Twenty age- and sex-matched healthy individuals (mean age: 44 +/- 12 years, 9 male) were taken as a control group. All participants underwent echocardiography both before and after GHRT. The patients before GHRT and control subjects had similar left ventricular sizes and ejection fraction whereas patients before GHRT had impaired diastolic indices of left ventricle. Peak systolic annular velocity, which identifies myocardial longitudinal systolic function, was lower in patients before GHRT than in the control subjects (0.08 +/- 0.01 vs 0.10 +/- 0.02, P < .05) and improved after GHRT (0.09 +/- 0.03, P < .05). Adult-onset GH deficiency is associated with normal left ventricular sizes and preserved ejection fraction whereas longitudinal systolic function obtained by Doppler tissue imaging is deteriorated, which improves with 12 months of GHRT.
authors.affiliation: Department of Cardiology, Erciyes University School of Medicine, Kayseri, Turkey. iozdogru@erciyes.edu.tr <iozdogru@erciyes.edu.tr>
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Ozdogru
authors.forename: Fatih
authors.initials: F
authors.lastname: Tanriverdi
authors.forename: Ali
authors.initials: A
authors.lastname: Dogan
authors.forename: Mehmet Gungor
authors.initials: MG
authors.lastname: Kaya
authors.forename: Mehmet
authors.initials: M
authors.lastname: Tugrul Inanc
authors.forename: Nihat
authors.initials: N
authors.lastname: Kalay
authors.forename: Ramazan
authors.initials: R
authors.lastname: Topsakal
authors.forename: Kursad
authors.initials: K
authors.lastname: Unluhizarci
authors.forename: Hulusi
authors.initials: H
authors.lastname: Atmaca
authors.forename: Namik
authors.initials: N
authors.lastname: Kemal Eryol
authors.forename: Fahrettin
authors.initials: F
authors.lastname: Kelestimur
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D015150:Echocardiography, Doppler; D005260:Female; D006321:Heart / Q000187:drug effects* / Q000503:physiopathology; D020249:Hormone Replacement Therapy; D019382:Human Growth Hormone / Q000172:deficiency* / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome
chemical_list: D019382:Human Growth Hormone