Increased expression of uteroglobin associated with tubal inflammation and ectopic pregnancy.
OBJECTIVE
Evaluation of uteroglobin (UG) expression in the fallopian tube in different tubal diseases.


METHODS
The UG was screened and quantified in samples of fallopian tubes from patients with salpingitis, hydrosalpinx, and ectopic pregnancy by exposing the UG with immunohistochemical techniques.


METHODS
University hospital and electron microscopy center.


METHODS
Women with pelvic inflammatory disease (PID) and complicated tubal ectopic pregnancy consulting for medical care.


METHODS
Salpingectomy.


METHODS
Tubal tissues were collected and examined using regular pathologic techniques. The UG immunoreactivity in the tubal epithelium was also assessed.


RESULTS
Fallopian tube epithelium displayed an increased UG expression in patients with PID and complicated tubal pregnancy compared with control patients.


CONCLUSIONS
Uteroglobin is present in the human fallopian tube as a secretory protein and appears to be involved in immunosuppressive responses in the fallopian tube.
Quintar
Amado Alfredo
AA
Center of Electron Microscopy, School of Medical Sciences, National University of Cordoba, Cordoba, Argentina.
Mukdsi
Jorge Humberto
JH
del Valle Bonaterra
Mónica
M
Aoki
Agustín
A
Maldonado
Cristina Alicia
CA
Pérez Alzaa
José
J
D000328:Adult; D005187:Fallopian Tubes / Q000276:immunology / Q000378:metabolism* / Q000601:surgery; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007249:Inflammation / Q000209:etiology*; D011247:Pregnancy; D011271:Pregnancy, Ectopic / Q000235:genetics*; D012488:Salpingitis / Q000601:surgery; D014598:Uteroglobin / Q000378:metabolism*
D014598:Uteroglobin