title: Colorectal neoplasm in asymptomatic Asians: a prospective multinational multicenter colonoscopy survey.
abstract: BACKGROUND
  Colorectal neoplasm is rapidly increasing in Asia, but a guideline for screening is not available.
  
  
  OBJECTIVE
  To evaluate the characteristics of colorectal neoplasm in asymptomatic Asian subjects.
  
  
  METHODS
  Prospective cohort study.
  
  
  METHODS
  Multinational multicenters, including both primary and referral centers in Asia.
  
  
  METHODS
  A total of 860 consecutive asymptomatic adults undergoing screening colonoscopy in 11 Asian cities from July 2004 to December 2004. Patients under 16 years old; those patients with a colorectal resection history, colonoscopies, or barium enema within 5 years; symptoms suggestive of colorectal diseases; and those who had undergone surveillance colonoscopy were excluded.
  
  
  METHODS
  The incidence and distribution of colorectal neoplasm and advanced neoplasm.
  
  
  RESULTS
  The mean age (+/-SD) was 54.4+/-11.6 years; 471 were men (54.8%). The prevalence of colorectal neoplasm and advanced neoplasm was 18.5% and 4.5%, respectively. Male sex, advancing age, and a family history of colorectal cancer were risk factors for advanced neoplasm. Of the 168 patients with colorectal neoplasm, 76 had distal neoplasm only (45.2%), 66 had proximal neoplasm only (39.3%), and 26 had both proximal and distal neoplasms (15.5%). Although the presence of distal advanced neoplasm was a significant risk factor for proximal advanced neoplasm, 14 of the 758 subjects without distal neoplasm had proximal advanced neoplasm (1.8%).
  
  
  CONCLUSIONS
  The small number of enrolled subjects, especially from certain ethnic groups.
  
  
  CONCLUSIONS
  The overall prevalence of advanced colorectal neoplasm in asymptomatic Asians is comparable with the West. Male sex, advancing age, and a family history of colorectal cancer were associated with a higher risk of advanced neoplasm.
authors.affiliation: Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
authors.forename: Jeong-Sik
authors.initials: JS
authors.lastname: Byeon
authors.forename: Suk-Kyun
authors.initials: SK
authors.lastname: Yang
authors.forename: Tae Il
authors.initials: TI
authors.lastname: Kim
authors.forename: Won Ho
authors.initials: WH
authors.lastname: Kim
authors.forename: James Y W
authors.initials: JY
authors.lastname: Lau
authors.forename: Wai-Keung
authors.initials: WK
authors.lastname: Leung
authors.forename: Rikiya
authors.initials: R
authors.lastname: Fujita
authors.forename: Govind K
authors.initials: GK
authors.lastname: Makharia
authors.forename: Murdan
authors.initials: M
authors.lastname: Abdullah
authors.forename: Ida
authors.initials: I
authors.lastname: Hilmi
authors.forename: Jose
authors.initials: J
authors.lastname: Sollano
authors.forename: Khay-Guan
authors.initials: KG
authors.lastname: Yeoh
authors.forename: Deng-Chyang
authors.initials: DC
authors.lastname: Wu
authors.forename: Min Hu
authors.initials: MH
authors.lastname: Chen
authors.forename: Pradermchai
authors.initials: P
authors.lastname: Kongkam
authors.forename: Joseph J Y
authors.initials: JJ
authors.lastname: Sung
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D003113:Colonoscopy; D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000208:ethnology*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011159:Population Surveillance / Q000379:methods*; D015995:Prevalence; D011446:Prospective Studies; D012307:Risk Factors; D017678:Sex Distribution