title: Assembly and trafficking of heterotrimeric G proteins.
abstract: To be activated by cell surface G protein-coupled receptors, heterotrimeric G proteins must localize at the cytoplasmic surface of plasma membranes. Moreover, some G protein subunits are able to traffic reversibly from the plasma membrane to intracellular locations upon activation. This current topic will highlight new insights into how nascent G protein subunits are assembled and how they arrive at plasma membranes. In addition, recent reports have increased our knowledge of activation-induced trafficking of G proteins. Understanding G protein assembly and trafficking will lead to a greater understanding of novel ways that cells regulate G protein signaling.
authors.affiliation: Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA..
authors.forename: Yannick
authors.initials: Y
authors.lastname: Marrari
authors.forename: Marykate
authors.initials: M
authors.lastname: Crouthamel
authors.forename: Roshanak
authors.initials: R
authors.lastname: Irannejad
authors.forename: Philip B
authors.initials: PB
authors.lastname: Wedegaertner
mesh_terms: D002462:Cell Membrane / Q000502:physiology*; D019281:Dimerization; D044385:GTP-Binding Protein alpha Subunits / Q000096:biosynthesis; D044387:GTP-Binding Protein beta Subunits / Q000096:biosynthesis; D044388:GTP-Binding Protein gamma Subunits / Q000096:biosynthesis; D020962:Heterotrimeric GTP-Binding Proteins / Q000737:chemistry* / Q000378:metabolism*; D008954:Models, Biological; D017510:Protein Folding; D017368:Protein Prenylation; D011499:Protein Processing, Post-Translational; D021381:Protein Transport / Q000502:physiology; D043562:Receptors, G-Protein-Coupled / Q000502:physiology
chemical_list: D044385:GTP-Binding Protein alpha Subunits; D044387:GTP-Binding Protein beta Subunits; D044388:GTP-Binding Protein gamma Subunits; D043562:Receptors, G-Protein-Coupled; D020962:Heterotrimeric GTP-Binding Proteins