Synthesis of new polyether glycodendrons as oligosaccharide mimetics.
Divalent and tetravalent glycomimetics based on polyether glycodendrons have been prepared. The branched scaffolds were decorated with galactose moieties on one hand and were elaborated into new glycodendrons of a 'mixed' type on the other, carrying both galactose and mannose moieties as biologically important sugar epitopes. All synthesized glycodendrons possess a focal point that can be employed for further derivatization and functionalization.
Elsner
Katharina
K
Otto Diels Institute of Organic Chemistry, Christiana Albertina University of Kiel, Otto-Hahn-Platz 4, D-24098 Kiel, Germany.
Boysen
Mike M K
MM
Lindhorst
Thisbe K
TK
D002236:Carbohydrate Conformation; D004987:Ethers / Q000138:chemical synthesis / Q000737:chemistry*; D005690:Galactose / Q000737:chemistry; D006001:Glycoconjugates / Q000138:chemical synthesis* / Q000737:chemistry*; D008358:Mannose; D008958:Models, Molecular; D009005:Monosaccharides / Q000737:chemistry; D009844:Oligosaccharides / Q000138:chemical synthesis / Q000737:chemistry*
D004987:Ethers; D006001:Glycoconjugates; D009005:Monosaccharides; D009844:Oligosaccharides; D008358:Mannose; D005690:Galactose