title: Immunosuppressive lignans isolated from Saururus chinensis.
abstract: Bioactivity-guided fractionation of Saururus chinensis (Saururaceae) using a lymphoproliferation assay led us to isolate 5 lignans (compounds 1 - 5). Compounds 1 - 5 were identified as sauchinone, (-)-saucerneol, saucerneol C, manassantin A, and manassantin B, respectively, by spectroscopic analyses. The immunosuppressive activities of the active compounds were evaluated using lymphoproliferation, mixed leukocyte response, and Th1/Th2 cytokine assays. The relative potency was in the order: manassantin A, B > (-)-saucerneol > saucerneol C > sauchinone.
authors.affiliation: Korea Institute of Toxicology, Daejeon, Korea.
authors.forename: Shin-Young
authors.initials: SY
authors.lastname: Park
authors.forename: Sung Hak
authors.initials: SH
authors.lastname: Lee
authors.forename: Woo Hyuck
authors.initials: WH
authors.lastname: Choi
authors.forename: Eun Mi
authors.initials: EM
authors.lastname: Koh
authors.forename: Jee Hee
authors.initials: JH
authors.lastname: Seo
authors.forename: Shi Yong
authors.initials: SY
authors.lastname: Ryu
authors.forename: Young Sup
authors.initials: YS
authors.lastname: Kim
authors.forename: Dae Young
authors.initials: DY
authors.lastname: Kwon
authors.forename: Woo Suk
authors.initials: WS
authors.lastname: Koh
mesh_terms: D049109:Cell Proliferation / Q000187:drug effects; D016207:Cytokines / Q000378:metabolism; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D017705:Lignans / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D007959:Lymphocyte Culture Test, Mixed; D008214:Lymphocytes / Q000187:drug effects* / Q000378:metabolism*; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D032134:Saururaceae
chemical_list: D016207:Cytokines; D007166:Immunosuppressive Agents; D017705:Lignans; D010936:Plant Extracts