Angiotensin-converting enzyme 2 in acute respiratory distress syndrome.
Angiotensin-converting enzyme (ACE) and ACE2 are highly homologous metalloproteases that provide essential catalytic functions in the renin-angiotensin system (RAS). Angiotensin II is one key effector peptide of the RAS, inducing vasoconstriction and exerting multiple biological functions. ACE cleaves angiotensin I to generate angiotensin II, whereas ACE2 reduces angiotensin II levels. Accumulating evidence has demonstrated a physiological and pathological role of ACE2 in the cardiovascular systems. Intriguingly, the SARS coronavirus, the cause of severe acute respiratory syndrome (SARS), utilizes ACE2 as an essential receptor for cell fusion and in vivo infections. Moreover, recent studies have demonstrated that ACE2 protects murine lungs from acute lung injury as well as SARS-Spike protein-mediated lung injury, suggesting a dual role of ACE2 in SARS infections and protection from ARDS.
Imai
Y
Y
IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr. Bohrgasse 3, 1030 Vienna, Austria. yumiko.imai@imba.oeaw.ac.at
Kuba
K
K
Penninger
J M
JM
D000085962:Angiotensin-Converting Enzyme 2; D000818:Animals; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D008954:Models, Biological; D007703:Peptidyl-Dipeptidase A / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*; D011654:Pulmonary Edema / Q000201:enzymology; D012084:Renin-Angiotensin System / Q000502:physiology; D012128:Respiratory Distress Syndrome / Q000201:enzymology* / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control; D045169:Severe Acute Respiratory Syndrome / Q000201:enzymology
D007703:Peptidyl-Dipeptidase A; C000705307:ACE2 protein, human; C000705328:Ace2 protein, mouse; D000085962:Angiotensin-Converting Enzyme 2