title: Psychometric properties of a prostate cancer radiation late toxicity questionnaire.
abstract: BACKGROUND
  To construct a short prostate cancer radiation late toxicity (PCRT) questionnaire with health-related quality-of-life (HRQoL) domains.
  
  
  METHODS
  The PCRT was developed by item generation, questionnaire construction (n = 7 experts, n = 8 focus group patients), pilot testing (n = 37), item reduction (n = 100), reliability testing (n = 237), and validity testing (n = 274).
  
  
  RESULTS
  Reliability of the three item-reduced subscales demonstrated intraclass correlation coefficients (CC) of 0.811 (GU), 0.842 (GI), and 0.740 (sexual). Discriminant validity demonstrated Pearson CC of 0.449 (GU-GI), 0.200 (sexual-GU), and 0.09 (sexual-GI). Content validity correlations between PCRT-PCQoL were 0.35-0.78, PCRT-FACT-G(c) were 0.19-0.39, and PCRT-SF-36(R) were 0.03-0.34.
  
  
  CONCLUSIONS
  We successfully generated a PCRT HRQoL questionnaire including subscales with very good psychometric properties.
authors.affiliation: Department of Oncology, University of Western Ontario, London, Ontario, Canada. george.rodrigues@lhsc.on.ca
authors.forename: George
authors.initials: G
authors.lastname: Rodrigues
authors.forename: Glenn
authors.initials: G
authors.lastname: Bauman
authors.forename: Michael
authors.initials: M
authors.lastname: Lock
authors.forename: David
authors.initials: D
authors.lastname: D'Souza
authors.forename: Jeff
authors.initials: J
authors.lastname: Mahon
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001918:Brachytherapy / Q000009:adverse effects*; D017144:Focus Groups; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009864:Ontario; D017063:Outcome Assessment, Health Care / Q000379:methods*; D010865:Pilot Projects; D011471:Prostatic Neoplasms / Q000523:psychology / Q000532:radiotherapy* / Q000601:surgery / Q000628:therapy; D011594:Psychometrics / Q000295:instrumentation*; D011788:Quality of Life; D018787:Radiation Oncology; D011839:Radiation, Ionizing; D011878:Radiotherapy / Q000009:adverse effects; D018434:Sickness Impact Profile; D011795:Surveys and Questionnaires / Q000592:standards*