Sentinel lymph node biopsy and non-sentinel node involvement in special type breast carcinomas with a good prognosis.
This study aimed at identifying factors related to sentinel lymph node (SLN) involvement in patients with tubular, cribriform, mucinous or papillary breast carcinoma and those related to non-SLN metastases if an SLN was positive. Multivariate analyses involved logistic and stepwise regressions. The SLNs harboured metastases in 85 of 572 cases, 78 of whom underwent axillary dissection; 19 presented non-SLN positive disease. Lack of lymphovascular invasion, a tumour size < or = 10 mm and a single SLN removed were the factors predicting an SLN metastasis rate <10%, and patients with these features could be candidates for no surgical axillary staging. A positive SLN proportion of < or = 50% and no lymphovascular invasion were associated with a <10% rate of non-SLN invasion; patients with a positive SLN and these features could be candidates for the omission of completion axillary dissection. The opposite presentation of these factors would mandate SLN biopsy and axillary dissection, respectively.
Cserni
Gábor
G
Department of Pathology, Bács-Kiskun County Teaching Hospital, Nyiri út 38, H-6000 Kecskemét, Hungary. cserni@freemail.hu
Bianchi
Simonetta
S
Vezzosi
Vania
V
Arisio
Riccardo
R
Bori
Rita
R
Peterse
Johannes L
JL
Sapino
Anna
A
Drijkoningen
Maria
M
Kulka
Janina
J
Eusebi
Vincenzo
V
Foschini
Maria Pia
MP
Bellocq
Jean-Pierre
JP
Marin
Cristi
C
Thorstenson
Sten
S
Amendoeira
Isabel
I
Reiner-Concin
Angelika
A
Decker
Thomas
T
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001940:Breast / Q000473:pathology*; D001943:Breast Neoplasms / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008197:Lymph Node Excision / Q000379:methods; D008207:Lymphatic Metastasis; D008875:Middle Aged; D011379:Prognosis; D012044:Regression Analysis; D021701:Sentinel Lymph Node Biopsy / Q000379:methods