Effect of prolactin and bromocriptine on the population of prostate neuroendocrine cells from intact and cyproterone acetate-treated rats: stereological and immunohistochemical study.
This work deals with the quantification of serotonin-immunoreactive prostate neuroendocrine cells (NECs) in rats exposed to prolactin in normal, cyproterone acetate-exposed, and bromocriptine-exposed animals to establish the possible influence of prolactin with or without androgenic blockade on this cell population. Thirty male peripubertal Sprague-Dawley rats were grouped as controls (CT) and those treated with cyproterone acetate (CA), cyproterone acetate plus prolactin, cyproterone acetate plus bromocriptine, prolactin (PL), and bromocriptine (BC). The volume of ductal epithelium (Vep) and total number (NSER) of the NECs serotonin-immunoreactive were measured. NECs were detected in the periurethral ducts. Compared to CT, Vep was increased in PL and BC and NSER was decreased in CA and increased in the prolactin or bromocriptine groups. The androgenic blockade decreases NSER in rat prostate; PL induces in normal and cyproterone acetate-treated rats the increase of NSER; and BC exerts a local effect over the prostate similar to that described for PL.
Ingelmo
Ildefonso
I
Department of Anaesthesiology, Hospital Ramon and Cajal, Madrid, Spain.
Gómez
Vicente
V
Martín
Rocio
R
Codesal
Javier
J
Rodríguez
Rosario
R
Pozuelo
Jose M
JM
Santamaría
Luis
L
D000726:Androgen Antagonists / Q000494:pharmacology*; D000818:Animals; D001971:Bromocriptine / Q000494:pharmacology*; D002369:Castration / Q000379:methods; D002452:Cell Count; D048430:Cell Shape; D048429:Cell Size; D017373:Cyproterone Acetate / Q000494:pharmacology*; D004847:Epithelial Cells / Q000187:drug effects / Q000473:pathology; D006727:Hormone Antagonists / Q000494:pharmacology*; D008297:Male; D009490:Neurosecretory Systems / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D011388:Prolactin / Q000037:antagonists & inhibitors / Q000378:metabolism* / Q000494:pharmacology; D011467:Prostate / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012701:Serotonin / Q000378:metabolism*
D000726:Androgen Antagonists; D006727:Hormone Antagonists; D012701:Serotonin; D001971:Bromocriptine; D017373:Cyproterone Acetate; D011388:Prolactin