Synthesis and antiproliferative activity of clausine E, mukonine, and koenoline bioisosteres.
Aza-analogues of clausine E, mukonine and koenoline were prepared from 1-(benzenesulfonyl)-1H-pyrrolo[2,3-b]pyridine-3-carboxaldehyde and their antiproliferative activity was evaluated against miscellaneous cancer cell lines and compared to those obtained with clausine E and mukonine.
Liger
François
F
Laboratoire de Chimie Organique 1, UMR - CNRS 5181, Université Claude Bernard - Lyon 1, Bâtiment 308 - CPE, 43 Boulevard du 11 Novembre 1918, 69622 Villeurbanne Cedex, France.
Popowycz
Florence
F
Besson
Thierry
T
Picot
Laurent
L
Galmarini
Carlos M
CM
Joseph
Benoît
B
D002227:Carbazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D015394:Molecular Structure; D009930:Organic Chemicals / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D002227:Carbazoles; D009930:Organic Chemicals; C522708:clausine E; C522710:koenoline; C522709:mukonine