title: Epidemiology, diagnosis and treatment of chronic hepatitis B in HIV-infected patients (EPIB 2005 STUDY).
abstract: OBJECTIVE
  To describe the characteristics of hepatitis B (HBV) infection in HIV-infected patients and the impact of anti-HBV treatments.
  
  
  METHODS
  All the patients with past or present chronic HBV infection seen in October 2005 in 17 French hospitals were included. Data were retrospectively collected from their first visit in a time-dependent manner, through a detailed standardized questionnaire.
  
  
  RESULTS
  Among 477 HBV-infected patients, 261 (55%) were co-infected with HIV. The HBV-HIV co-infected patients underwent fewer serological, virological and histological evaluations. Initial positive HBe antigenemia (HBe Ag) was more frequent in these patients (57.9 versus 28.6%; P < 10), as was cirrhosis on the initial liver biopsy (17.9 versus 7.6%; P = 0.05). Throughout the mean 5-year follow-up, HBe Ag loss was less frequent (P = 0.04), as was HBe seroconversion (incidence rate 2.6 versus 10/100 patient-years; P < 10). HBe Ag loss was associated with fibrosis improvement (METAVIR score -0.5 +/- 0.4 versus +0.2 +/- 0.6 if persistent positive HBe Ag, P = 0.01). In co-infected patients on tenofovir, adefovir or interferon, HBe seroconversions were seen in patients on combined HBV treatment, the use of which is increasing (58% in 2005). Nevertheless, no significant difference in virological, immunological or biochemical evolution was observed between these different treatments.
  
  
  CONCLUSIONS
  In HBV-HIV co-infected patients, the assessment of HBV infection still needs to be improved, the HBV wild-type remains predominant, and HBe Ag loss is rare and associated with a better histological evolution. There is insufficient evidence of the superiority of combined HBV treatment, and this still needs be demonstrated in long term studies.
authors.affiliation: Service de Maladies Infectieuses et Tropicales, CHU Dijon, 10 boulevard du Maréchal de Lattre de Tassigny, 21079 Dijon cedex, France. lionel.piroth@chu-dijon.fr
authors.forename: Lionel
authors.initials: L
authors.lastname: Piroth
authors.forename: Damien
authors.initials: D
authors.lastname: Sène
authors.forename: Stanislas
authors.initials: S
authors.lastname: Pol
authors.forename: Isabelle
authors.initials: I
authors.lastname: Goderel
authors.forename: Karine
authors.initials: K
authors.lastname: Lacombe
authors.forename: Benoit
authors.initials: B
authors.lastname: Martha
authors.forename: David
authors.initials: D
authors.lastname: Rey
authors.forename: Véronique
authors.initials: V
authors.lastname: Loustau-Ratti
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Bergmann
authors.forename: Gilles
authors.initials: G
authors.lastname: Pialoux
authors.forename: Anne
authors.initials: A
authors.lastname: Gervais
authors.forename: Caroline
authors.initials: C
authors.lastname: Lascoux-Combe
authors.forename: Fabrice
authors.initials: F
authors.lastname: Carrat
authors.forename: Patrice
authors.initials: P
authors.lastname: Cacoub
mesh_terms: D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D005602:France / Q000453:epidemiology; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy / Q000453:epidemiology; D018023:HIV Seronegativity; D006679:HIV Seropositivity / Q000150:complications / Q000453:epidemiology; D006514:Hepatitis B Surface Antigens / Q000032:analysis; D006513:Hepatitis B e Antigens / Q000032:analysis; D006515:Hepatitis B virus / Q000187:drug effects; D019694:Hepatitis B, Chronic / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology*; D006801:Humans; D008099:Liver / Q000473:pathology; D008297:Male; D012189:Retrospective Studies
chemical_list: D000998:Antiviral Agents; D004279:DNA, Viral; D006514:Hepatitis B Surface Antigens; D006513:Hepatitis B e Antigens