title: [Optimization of preparation for matrine-loaded magnetic chitosan microspheres].
abstract: OBJECTIVE
  To study the technique of preparation and optimization of magnetic chitosan microspheres.
  
  
  METHODS
  Magnetic fluid was produced by co-precipitation method and magnetic chitosan microspheres were produced using a convenient method of ionic gelation. A global optimization algorithm was used to optimize the parameters.
  
  
  RESULTS
  The formulated magenetic fluid and microspheres were characterized size and the size distribution. The average particle size of magnetic fluid and matrine-loaded chitosan magnetic microspheres were found to be 152.2 nm and 682.4 nm.
  
  
  CONCLUSIONS
  Global optimization algorithm is an efficient method to optimize the parameters.
authors.affiliation: College of Chemical Engineering, Wuhan University of Technology, Wuhan 430070, China.
authors.forename: Xiao-ping
authors.initials: XP
authors.lastname: Liu
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.forename: Lie-xiang
authors.initials: LX
authors.lastname: Yan
authors.forename: Bin
authors.initials: B
authors.lastname: Shi
mesh_terms: D000470:Alkaloids / Q000008:administration & dosage* / Q000737:chemistry; D002626:Chemistry, Pharmaceutical; D048271:Chitosan / Q000737:chemistry*; D004337:Drug Carriers; D008280:Magnetics; D008863:Microspheres; D010316:Particle Size; D011807:Quinolizines / Q000008:administration & dosage* / Q000737:chemistry; D012995:Solubility; D013678:Technology, Pharmaceutical / Q000379:methods; D000093842:Matrines
chemical_list: D000470:Alkaloids; D004337:Drug Carriers; D011807:Quinolizines; D048271:Chitosan; D000093842:Matrines