An analysis of the physiological FDG uptake in the stomach with the water gastric distention method.
OBJECTIVE
Physiological FDG uptake in the stomach is a common phenomenon, especially noted at the cardia. Water intake just before scanning will result in gastric distention and thinning of the gastric wall, which in turn may lead to a reduction in the physiological uptake in the gastric wall. In the current study, we investigated whether gastric distention by water intake just before PET imaging reduces physiological FDG uptake in the stomach.


METHODS
The patient population comprised 60 patients who underwent whole-body FDG-PET imaging for cancer screening following gastroscopy performed within the preceding week. All patients took 400 ml of water for hydration and were administered 185 MBq of FDG intravenously. The patients were randomly divided into two groups: a group with additional water intake (AW group; n = 30) and a group without additional water intake (NW group; n = 30). In the AW group, an additional 400 ml of water was given just before PET imaging. For quantitative analysis, the stomach was classified into three areas [upper (U), middle (M) and lower (L)], and the degree of FDG uptake in each area was evaluated using standardised uptake values (SUVs).


RESULTS
In the NW group, the mean SUVs in the U, M and L areas were 2.41 +/- 0.75, 2.28 +/- 0.73 and 1.61 +/- 0.89, respectively, while in the AW group they were 1.82 +/- 0.66, 1.73 +/- 0.56 and 1.48 +/- 0.49, respectively, and 2.21 +/- 0.38 in the oesophago-gastric junction. The mean SUVs in the U and M areas in the AW group were significantly lower than those in the NW group (p < 0.05).


CONCLUSIONS
Additional water intake just before PET imaging is an effective method for suppressing physiological FDG uptake in the stomach.
Kamimura
Kiyohisa
K
Department of Radiology, Fujimoto Hayasuzu Hospital, 17-1 Hayasuzu-cho, Miyakonojo, Miyazaki 885-0055, Japan. kiyohisa@mp.0038.net
Fujita
Seigo
S
Nishii
Ryuichi
R
Wakamatsu
Hideyuki
H
Nagamachi
Shigeki
S
Yano
Tatsuhiko
T
Ogita
Mikio
M
Umemura
Yoshiro
Y
Fujimoto
Toshiro
T
Nakajo
Masayuki
M
D000284:Administration, Oral; D000328:Adult; D000368:Aged; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics*; D005753:Gastric Mucosa / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D013270:Stomach / Q000000981:diagnostic imaging* / Q000187:drug effects; D014867:Water / Q000008:administration & dosage* / Q000378:metabolism*
D019275:Radiopharmaceuticals; D014867:Water; D019788:Fluorodeoxyglucose F18