title: Synthesis and antiproliferative activity of clausine E, mukonine, and koenoline bioisosteres.
abstract: Aza-analogues of clausine E, mukonine and koenoline were prepared from 1-(benzenesulfonyl)-1H-pyrrolo[2,3-b]pyridine-3-carboxaldehyde and their antiproliferative activity was evaluated against miscellaneous cancer cell lines and compared to those obtained with clausine E and mukonine.
authors.affiliation: Laboratoire de Chimie Organique 1, UMR - CNRS 5181, Université Claude Bernard - Lyon 1, Bâtiment 308 - CPE, 43 Boulevard du 11 Novembre 1918, 69622 Villeurbanne Cedex, France.
authors.forename: François
authors.initials: F
authors.lastname: Liger
authors.forename: Florence
authors.initials: F
authors.lastname: Popowycz
authors.forename: Thierry
authors.initials: T
authors.lastname: Besson
authors.forename: Laurent
authors.initials: L
authors.lastname: Picot
authors.forename: Carlos M
authors.initials: CM
authors.lastname: Galmarini
authors.forename: Benoît
authors.initials: B
authors.lastname: Joseph
mesh_terms: D002227:Carbazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D015394:Molecular Structure; D009930:Organic Chemicals / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D002227:Carbazoles; D009930:Organic Chemicals; C522708:clausine E; C522710:koenoline; C522709:mukonine