New catalysts for Suzuki-Miyaura coupling reactions of heteroatom-substituted heteroaryl chlorides.
The new air-stable PdCl2[PR2(Ph-R')]2 complexes, readily prepared from commercial reagents, exhibit unique efficiency as catalysts for the Suzuki-Miyaura coupling reactions of a variety of heteroatom-substituted heteroaryl chlorides with a diverse range of aryl/heteroaryl boronic acids. The coupling reactions catalyzed by the new complexes exhibit high product yields (88-99%) and high catalyst turnover numbers (up to 10,000 TON).
Guram
Anil S
AS
Chemistry Research and Discovery, Amgen Inc., Thousand Oaks, California 91320-1799, USA. aguram@amgen.com
Wang
Xiang
X
Bunel
Emilio E
EE
Faul
Margaret M
MM
Larsen
Robert D
RD
Martinelli
Michael J
MJ