HLA-DQB1*0319, a novel HLA-DQB1 allele, shows strong haplotype association to HLA-DRB1*1102.
The new human leukocyte antigen-DQB1*0319 allele was identified in a prospective bone marrow donor by sequence-based typing. This novel allele differs from the DQB1*0301 allele at nucleotide position 554 (C-->T), which results in a Thr to Ile amino acid exchange. The new allele shows a strong association to DRB1*1102, suggesting that the haplotype DRB1*1102-DQB1*0319 is quite common.
Witter
K
K
Laboratory of Immunogenetics, University Munich, Max-Lebsche-Platz 32, 81377 Munich, Germany. klaus.witter@med.uni-muenchen.de
Mautner
J
J
Albert
T
T
Zahn
R
R
Kauke
T
T
D000483:Alleles; D001483:Base Sequence; D017931:DNA Primers; D005091:Exons; D006683:HLA-DQ Antigens / Q000235:genetics*; D059866:HLA-DQ beta-Chains; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006239:Haplotypes; D006579:Heterozygote; D006650:Histocompatibility Testing; D006801:Humans; D007438:Introns; D007532:Isoleucine / Q000378:metabolism; D015810:Linkage Disequilibrium; D019520:Living Donors; D008562:Membrane Glycoproteins / Q000235:genetics*; D008969:Molecular Sequence Data; D021141:Nucleic Acid Amplification Techniques; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D017422:Sequence Analysis, DNA
D017931:DNA Primers; D006683:HLA-DQ Antigens; D059866:HLA-DQ beta-Chains; C069051:HLA-DQB1 antigen; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; D008562:Membrane Glycoproteins; D007532:Isoleucine