title: Sucrose, xylitol, and erythritol increase PMMA permeability for depot antibiotics.
abstract: Release of antibiotics from antibiotic-loaded PMMA is dependent on its permeability. Loading PMMA with soluble particulate filler has been proposed to increase permeability and antibiotic release for beads and spacers. We therefore assessed particulate sucrose, xylitol, and erythritol as fillers to increase the permeability and elution kinetics of filler-loaded PMMA. Based on lower solubility, we hypothesized that erythritol would not enhance permeability and elution as much as xylitol and sucrose. We made filler-loaded PMMA beads with each of the three fillers combined with phenolphthalein, and soaked in 0.1% NaOH solution. Permeability was assessed qualitatively by relative depth of phenolphthalein color change caused by penetration of NaOH solution into subsequently split beads. Elution was quantitatively assessed by spectrophotometric light absorption measurements of the eluent. Fluid penetration reached the center of 7-mm beads by day 15, similar for all three materials. Elution of phenolphthalein was greater for xylitol than for the other two materials. Particulate sucrose, xylitol, and erythritol fillers increase PMMA permeability and elution kinetics but relative solubility did not determine the relative degree of enhancement of permeability and elution by these materials.
authors.affiliation: Banner Good Samaritan Medical Center, Phoenix, AZ, USA.
authors.forename: Alex C
authors.initials: AC
authors.lastname: McLaren
authors.forename: Sandra G
authors.initials: SG
authors.lastname: McLaren
authors.forename: Miranda K
authors.initials: MK
authors.lastname: Hickmon
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D003116:Color; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D004896:Erythritol / Q000494:pharmacology*; D008422:Materials Testing; D008863:Microspheres; D010539:Permeability / Q000187:drug effects; D020113:Phenolphthalein; D019904:Polymethyl Methacrylate / Q000493:pharmacokinetics*; D013395:Sucrose / Q000494:pharmacology*; D014993:Xylitol / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D013395:Sucrose; D020113:Phenolphthalein; D019904:Polymethyl Methacrylate; D004896:Erythritol; D014993:Xylitol