title: A prospective randomized comparison of diagnostic efficacy between transperineal and transrectal 12-core prostate biopsy.
abstract: The aim of this study is to elucidate the diagnostic efficacy between transperineal and transrectal 12-core prostate biopsy for prostate cancer. We prospectively randomized 200 consecutive men into two groups to undergo systematic prostate biopsy. Overall positivity for cancer was similar (47% by transperineal and 53% by transrectal; P=0.480). However, in case with 'gray zone' PSA (from 4.1 to 10.0 ng/ml), significantly more cores were positive when approach was transperineal, especially among transition zone cores. Therefore, urologist preferences are sufficient for choosing an approach, except for a possible small advantage of transperineal biopsy when PSA is in gray zone.
authors.affiliation: Division of Urology, Department of Organ Therapeutics, Kobe University Graduate School of Medicine, Kobe, Japan. atake@med.kobe-u.ac.jp
authors.forename: A
authors.initials: A
authors.lastname: Takenaka
authors.forename: R
authors.initials: R
authors.lastname: Hara
authors.forename: T
authors.initials: T
authors.lastname: Ishimura
authors.forename: T
authors.initials: T
authors.lastname: Fujii
authors.forename: Y
authors.initials: Y
authors.lastname: Jo
authors.forename: A
authors.initials: A
authors.lastname: Nagai
authors.forename: M
authors.initials: M
authors.lastname: Fujisawa
mesh_terms: D000368:Aged; D000775:Anesthesia, Spinal; D001707:Biopsy, Needle / Q000009:adverse effects / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010502:Perineum; D011446:Prospective Studies; D011467:Prostate / Q000000981:diagnostic imaging / Q000473:pathology*; D011469:Prostatic Diseases / Q000175:diagnosis / Q000473:pathology; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000473:pathology; D012007:Rectum; D012680:Sensitivity and Specificity; D018084:Ultrasonography, Interventional