title: The value of single umbilical artery in the prediction of fetal aneuploidy: findings in 12,672 pregnant women.
abstract: OBJECTIVE
  To assess the risk of the association of single umbilical artery and aneuploidies.
  
  
  METHODS
  In a general unselected obstetric population of 12,672 singleton pregnant women from January 1998 to December 2002, we detected 61 fetuses (prevalence, 0.48%) with single umbilical artery (SUA) on prenatal ultrasound at 16 to 23 menstrual weeks.
  
  
  RESULTS
  Among the 61 fetuses with 2-vessel cord, 39 (64%) had SUA as an isolated finding, and 22 (36%) had additional findings, either minor or major. One (2.56%) of the 39 fetuses with SUA as an isolated finding had aneuploidy (trisomy 21 at maternal age of 32 years), whereas 5 (41.6%) of the 12 fetuses with SUA concomitant with major anomalies were aneuploid. None of the 10 fetuses with SUA and minor anomalies had aneuploidy. Among the 12,611 women with 3-vessel cord, we instead found 8 cases of trisomy 21 (0.06%), 1 case of translocation 14-21 (0.007%), 5 cases of trisomy 18 (0.04%), 1 case of trisomy 13 (0.007%), 1 case of 47,XXX (0.007%), and 2 cases of monosomy X (0.01%).
  
  
  CONCLUSIONS
  In an unselected population, second trimester sonographic detection of SUA and major fetal anomalies indicate increased risk for fetal aneuploidy. However, even if this study is based on a large population, the only 1 case of trisomy 21 among the fetuses with SUA as an isolated finding is not sufficient to draw a conclusion, and larger studies are needed to confirm or infirm this single case.
authors.affiliation: Department of Obstetrics and Gynaecology, University of Messina, Messina, Italy. robertagr74@gmail.com
authors.forename: Roberta
authors.initials: R
authors.lastname: Granese
authors.forename: Claudio
authors.initials: C
authors.lastname: Coco
authors.forename: Philippe
authors.initials: P
authors.lastname: Jeanty
mesh_terms: D000293:Adolescent; D000328:Adult; D000782:Aneuploidy; D025063:Chromosome Disorders / Q000000981:diagnostic imaging*; D005260:Female; D005865:Gestational Age; D006801:Humans; D011237:Predictive Value of Tests; D011247:Pregnancy; D011248:Pregnancy Complications; D016216:Ultrasonography, Prenatal / Q000379:methods*; D014469:Umbilical Arteries / Q000002:abnormalities* / Q000000981:diagnostic imaging*