IGF-1 CA repeat variant and breast cancer risk in postmenopausal women.
IGF-I is an important growth factor for the mammary gland. We evaluated the relationship of the IGF-I CA(n) polymorphism with breast cancer risk in Caucasian postmenopausal women and performed a meta-analysis of published data. The IGF-I CA(n) polymorphism was genotyped in 4091 from the Rotterdam Study. A disease-free survival analysis was performed along with a meta-analysis of all available data on IGF-I CA(n) polymorphism and breast cancer risk. During follow-up 159 women were diagnosed with breast cancer. The disease-free survival analysis adjusted for age at entry, age at menopause, body mass index and waist hip ratio yielded a HR=0.97 (95% CI=0.59-1.58) for CA(19) non-carriers against carriers. The meta-analysis using the random-effects model gave a pooled OR of 1.26 (95% CI=0.95-1.82) for IGF-I CA(19) non-carriers versus CA(19) homozygous carriers. According to these results, the IGF-I CA(19) promoter polymorphism is not likely to predict the risk of breast cancer.
González-Zuloeta Ladd
A M
AM
Epidemiology & Biostatistics Department, Erasmus MC, Rotterdam, The Netherlands.
Liu
F
F
Houben
M P W A
MP
Arias Vásquez
A
A
Siemes
C
C
Janssens
A C J W
AC
Coebergh
J W W
JW
Hofman
A
A
Janssen
J A M J L
JA
Stricker
B H Ch
BH
van Duijn
C M
CM
D000368:Aged; D001943:Breast Neoplasms / Q000235:genetics*; D005260:Female; D005838:Genotype; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000235:genetics*; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D017698:Postmenopause / Q000235:genetics*; D012307:Risk Factors
D007334:Insulin-Like Growth Factor I