Turning back the clock on neurodegeneration.
Does neuronal loss associated with dementia necessarily impair the ability to learn new information and recall old memories? In a recent report in Nature, Fischer et al. (2007) show that the ability to learn and remember can be reestablished in a mouse model of dementia through either environmental enrichment or chronic treatment with an inhibitor of histone deacetylase.
Mangan
Kile P
KP
Department of Physiology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53719, USA.
Levenson
Jonathan M
JM
D000818:Animals; D003704:Dementia / Q000188:drug therapy / Q000628:therapy*; D004195:Disease Models, Animal; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D056572:Histone Deacetylase Inhibitors; D007858:Learning; D008568:Memory; D051379:Mice; D009410:Nerve Degeneration / Q000188:drug therapy / Q000628:therapy*
D004791:Enzyme Inhibitors; D056572:Histone Deacetylase Inhibitors