title: [Usefulness of contrast-enhanced ultrasonography in the differential diagnosis of polypoid gallbladder lesions].
abstract: We investigated the usefulness of contrast-enhanced ultrasonography for differential diagnosis of polypoid gallbladder lesions in 60 patients, consisting of gallbladder carcinoma in 20, adenoma in 2, benign polyp in 29, and adenomyomatosis in 9, comparing contrast enhancement patterns with pathologic findings. We monitored vascular flow for 120 sec, constructing a time intensity curve (TIC) by flash-echo imaging. We compared the number of vessels and vessel diameter determined by contrast enhancement patterns and by pathologic examination. Contrast enhancement patterns were classified as linear, scattered, diffuse, or branched. When diffuse type and branched type were considered as indicative of cancer, accuracy was 84.5%, sensitivity 100%, and specificity 76.9%. In gallbladder carcinoma, the TIC rose from no contrast to early-phase contrast sooner than in other diseases. In adenocarcinoma, high-intensity values persisted at 120 sec. With an intensity of 90 or greater at 120 sec taken as indicating cancer, accuracy was 89.7%, sensitivity 89.5%, and specificity 89.7%; Vessels were significantly more numerous in diffuse type cases than in those with other patterns. Vessel diameter was greatest in the diffuse type and the branched type patterns, both differing significantly from the linear type. Ultrasonographic contrast enhancement patterns show characteristic associations with pathologic findings and serve as valuable adjuncts in the diagnosis of gallbladder diseases.
authors.affiliation: Department of Internal Medicine, Fujita Health University, Banbuntane Hotokukai Hospital.
authors.forename: Masashi
authors.initials: M
authors.lastname: Hattori
authors.forename: Kazuo
authors.initials: K
authors.lastname: Inui
authors.forename: Junji
authors.initials: J
authors.lastname: Yoshino
authors.forename: Hironao
authors.initials: H
authors.lastname: Miyoshi
authors.forename: Kazumu
authors.initials: K
authors.lastname: Okushima
authors.forename: Yuta
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Takehito
authors.initials: T
authors.lastname: Naito
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Imaeda
authors.forename: Yoshimune
authors.initials: Y
authors.lastname: Horibe
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Hattori
authors.forename: Saburou
authors.initials: S
authors.lastname: Nakazawa
mesh_terms: D000236:Adenoma / Q000000981:diagnostic imaging* / Q000473:pathology; D018194:Adenomyoma / Q000000981:diagnostic imaging / Q000473:pathology; D003287:Contrast Media / Q000008:administration & dosage; D003937:Diagnosis, Differential; D005706:Gallbladder Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D006801:Humans; D009367:Neoplasm Staging; D011127:Polyps / Q000000981:diagnostic imaging* / Q000473:pathology; D018608:Ultrasonography, Doppler / Q000379:methods*
chemical_list: D003287:Contrast Media