Catalytic action of copper (II) ion on electrochemical oxidation of metformine and voltammetric determination of metformine in pharmaceuticals.
The catalytic effect of Cu(II) ion toward the oxidation of metformine (MET) have been observed in NH(3).H(2)O-NH(4)Cl buffer (pH 8.9; 0.1M). The oxidation peak current of imino-group in guanidino-group of MET at 0.95 V at carbon paste electrode (C/PE) in the presence of 2.0 x 10(-4)M Cu(II) ion was increased by about 20 times and the peak potential was unchanged compared with that in the absence of Cu(II) ion. Moreover, the oxidation peak current of MET at multiwalled carbon nanotube paste electrode (MWCNT/PE) was further increased by about three times compared with that at C/PE in the same medium. Based on the catalytic oxidation peak of MET by Cu(II) ion at MWCNT/PE, a voltammetric method for the determination of MET is developed. The peak current of the catalytic oxidation peak was proportional to MET concentration in the range of 2.0 x 10(-7) to 1.0 x 10(-5)M. The detection limit was 6.7 x 10(-8)M.
Tian
Xin-Juan
XJ
Institute of Analytical Science, Northwest University, Xi'an 710069, China.
Song
Jun-Feng
JF
D002021:Buffers; D002138:Calibration; D002244:Carbon / Q000737:chemistry; D002384:Catalysis; D002413:Cations, Divalent / Q000737:chemistry; D003300:Copper / Q000737:chemistry*; D004563:Electrochemistry / Q000379:methods; D004566:Electrodes; D006863:Hydrogen-Ion Concentration; D007004:Hypoglycemic Agents / Q000737:chemistry*; D008687:Metformin / Q000737:chemistry*; D037742:Nanotubes, Carbon / Q000737:chemistry; D010084:Oxidation-Reduction; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D011208:Powders / Q000737:chemistry; D013056:Spectrophotometry, Ultraviolet; D013607:Tablets / Q000737:chemistry; D013696:Temperature
D002021:Buffers; D002413:Cations, Divalent; D007004:Hypoglycemic Agents; D037742:Nanotubes, Carbon; D004364:Pharmaceutical Preparations; D011208:Powders; D013607:Tablets; D002244:Carbon; D003300:Copper; D008687:Metformin