Mamu-B*08-positive macaques control simian immunodeficiency virus replication.
Certain major histocompatibility complex (MHC) class I alleles are associated with the control of human immunodeficiency virus and simian immunodeficiency virus (SIV) replication. We have designed sequence-specific primers for detection of the rhesus macaque MHC class I allele Mamu-B*08 by PCR and screened a cohort of SIV-infected macaques for this allele. Analysis of 196 SIV(mac)239-infected Indian rhesus macaques revealed that Mamu-B*08 was significantly overrepresented in elite controllers; 38% of elite controllers were Mamu-B*08 positive compared to 3% of progressors (P = 0.00001). Mamu-B*08 was also associated with a 7.34-fold decrease in chronic phase viremia (P = 0.002). Mamu-B*08-positive macaques may, therefore, provide a good model to understand the correlates of MHC class I allele-associated immune protection and viral containment in human elite controllers.
Loffredo
John T
JT
Wisconsin National Primate Research Center, University of Wisconsin-Madison, 555 Science Drive, Madison, WI 53711, USA.
Maxwell
Jess
J
Qi
Ying
Y
Glidden
Chrystal E
CE
Borchardt
Gretta J
GJ
Soma
Taeko
T
Bean
Alex T
AT
Beal
Dominic R
DR
Wilson
Nancy A
NA
Rehrauer
William M
WM
Lifson
Jeffrey D
JD
Carrington
Mary
M
Watkins
David I
DI
D000483:Alleles; D000818:Animals; D001483:Base Sequence; D005820:Genetic Testing; D015395:Histocompatibility Antigens Class I / Q000235:genetics* / Q000378:metabolism; D008253:Macaca mulatta; D008969:Molecular Sequence Data; D016097:Simian Acquired Immunodeficiency Syndrome / Q000235:genetics* / Q000276:immunology; D015302:Simian Immunodeficiency Virus / Q000502:physiology*; D014766:Viremia / Q000235:genetics / Q000276:immunology; D014779:Virus Replication
D015395:Histocompatibility Antigens Class I