title: Abnormal retinal thickness in patients with mild cognitive impairment and Alzheimer's disease.
abstract: In Alzheimer's disease (AD), brain lesions are marked by severe neuronal loss and retinal degeneration was previously mentioned in affected patients. Mild cognitive impairment (MCI) is a clinical syndrome that could be an early phase of AD. In this study, using optical coherence tomography (OCT), the retinal nerve fiber layer (RNFL) thickness was assessed in patients with mild AD, moderate to severe AD, amnestic MCI and control subjects. The results show that RNFL thickness is statistically reduced in patients with MCI, mild AD or moderate to severe AD compared to controls. In addition, no statistical difference was found between the results in MCI patients and mild AD patients. The RNFL seems to be involved early during the course of amnestic MCI and OCT tests could be carried out in patients with cognitive troubles.
authors.affiliation: Department of Neurology, Poitiers University Hospital, 86021 Poitiers, France.
authors.forename: Claire
authors.initials: C
authors.lastname: Paquet
authors.forename: Michèle
authors.initials: M
authors.lastname: Boissonnot
authors.forename: Florent
authors.initials: F
authors.lastname: Roger
authors.forename: Paul
authors.initials: P
authors.lastname: Dighiero
authors.forename: Roger
authors.initials: R
authors.lastname: Gil
authors.forename: Jacques
authors.initials: J
authors.lastname: Hugon
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000150:complications* / Q000175:diagnosis* / Q000523:psychology; D003072:Cognition Disorders / Q000150:complications* / Q000175:diagnosis*; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D011237:Predictive Value of Tests; D012160:Retina / Q000473:pathology* / Q000503:physiopathology; D012162:Retinal Degeneration / Q000209:etiology* / Q000503:physiopathology; D012165:Retinal Ganglion Cells / Q000473:pathology; D041623:Tomography, Optical Coherence