title: Distortion product otoacoustic emissions at 6 months in term infants after perinatal hypoxia-ischaemia or with a low Apgar score.
abstract: Distortion product otoacoustic emissions (DPOAEs) were analyzed at 6 months of age in term infants who had perinatal hypoxia-ischaemia (HI) and those who had a low Agar score alone to detect any abnormalities in cochlear function and any difference between the two groups of infants. The f2 primary tone was presented at ten frequencies (0.5-10 kHz). Both the left and right ears were tested. Compared to normal term controls, both the infants after perinatal HI and those with a low Apgar score alone showed lower DPOAE pass rates, mainly at 1-4 kHz at which the pass rates were decreased significantly (P < 0.05-0.01). The general pattern of DPOAE pass rates at different frequencies was similar in the two groups of infants. The pass rates at 1, 5 and 6 kHz tended to be lower in the infants after perinatal HI than those with a low Apgar score alone, although not statistically significant. Conclusions At 6 months of age, infants after perinatal HI or with a low Apgar score alone had a relatively poor cochlear function, mainly at 1-4 kHz. There are no major differences between the two groups of infants.
authors.affiliation: Department of Paediatrics, Children's Hospital, Fudan University, Shanghai, China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Zang
authors.forename: Andrew Robert
authors.initials: AR
authors.lastname: Wilkinson
authors.forename: Ze Dong
authors.initials: ZD
authors.lastname: Jiang
mesh_terms: D000161:Acoustic Stimulation / Q000379:methods; D001034:Apgar Score; D006319:Hearing Loss, Sensorineural / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology*; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology*; D007223:Infant; D007231:Infant, Newborn; D017084:Otoacoustic Emissions, Spontaneous / Q000502:physiology*; D011379:Prognosis; D012307:Risk Factors