Cutaneous reactions with tenofovir disoproxil fumarate: a report of nine cases.
Adverse drug reactions causing the early discontinuation of therapy are common in patients with HIV infection. Hypersensitivity consisting mainly of a maculopapular rash on the face, extremities and trunk has been observed at a rate higher than expected in patients treated with tenofovir at our clinics. We therefore examined nine patients with suspected tenofovir hypersensitivity reactions in two indigent care HIV clinics. Type I and type IV hypersensitivity may be involved as immunological mechanisms.
Lockhart
Staci M
SM
University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
Rathbun
R Chris
RC
Stephens
Johnny R
JR
Baker
Damon L
DL
Drevets
Douglas A
DA
Greenfield
Ronald A
RA
Salvaggio
Michelle R
MR
Vincent
Simi
S
D000225:Adenine / Q000009:adverse effects / Q000031:analogs & derivatives*; D000328:Adult; D003875:Drug Eruptions / Q000209:etiology*; D004359:Drug Therapy, Combination; D005076:Exanthema / Q000139:chemically induced; D005260:Female; D015658:HIV Infections / Q000188:drug therapy*; D017320:HIV Protease Inhibitors / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D063065:Organophosphonates / Q000009:adverse effects*; D018894:Reverse Transcriptase Inhibitors / Q000009:adverse effects*; D012867:Skin / Q000187:drug effects*; D000068698:Tenofovir
D017320:HIV Protease Inhibitors; D063065:Organophosphonates; D018894:Reverse Transcriptase Inhibitors; D000068698:Tenofovir; D000225:Adenine