Effects of salicylic acid on mushroom tyrosinase and B16 melanoma cells.
Salicylic acid slightly inhibited the oxidation of L-3,4-dihydroxyphenylalanine (L-DOPA) catalyzed by mushroom tyrosinase noncompetitively without being oxidized. In contrast, 4-hydroxybenzoic acid did not inhibit this enzymatic oxidation if a longer reaction time was observed, although it suppressed the initial rate of the oxidation to a certain extent. Neither acid showed noticeable effects on cultured murine B16-F10 melanoma cells except weak cytotoxicity.
Tamura
Sadaaki
S
Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720-3114, USA.
Nitoda
Teruhiko
T
Kubo
Isao
I
D000363:Agaricales / Q000201:enzymology*; D048729:Anacardic Acids / Q000494:pharmacology; D000818:Animals; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D007700:Kinetics; D007980:Levodopa / Q000378:metabolism; D008543:Melanins / Q000378:metabolism; D008545:Melanoma / Q000473:pathology*; D051379:Mice; D014442:Monophenol Monooxygenase / Q000187:drug effects / Q000302:isolation & purification / Q000378:metabolism*; D010084:Oxidation-Reduction; D010101:Oxygen Consumption / Q000187:drug effects; D020156:Salicylic Acid / Q000494:pharmacology*
D048729:Anacardic Acids; D008543:Melanins; C088115:anacardic acid; D007980:Levodopa; D014442:Monophenol Monooxygenase; D020156:Salicylic Acid