title: OSAS in Down syndrome: T&A versus T&A plus lateral pharyngoplasty.
abstract: OBJECTIVE
  Obstructive Sleep Apnea Syndrome (OSAS) is common in children with Down syndrome (DS). Adenotonsillectomy (T&A) has traditionally been the initial surgical treatment. More aggressive surgery has also been recommended. Previous studies have used parental reporting and not objective data to assess treatment outcomes. Polysomnography (PSG) is used to objectively evaluate the results of T&A versus T&A plus lateral pharyngoplasty in the initial treatment of OSAS in children with DS.
  
  
  METHODS
  This is a retrospective study of children with OSAS and DS. Group 1 consisted of 21 children with DS who underwent T&A. Group 2 consisted of 16 children of similar age who had T&A plus lateral pharyngoplasty as initial surgical treatment. Post-operative PSG's were available for all patients. Apnea/hypopnea index (AHI), presence of hypoxemia and hypercarbia, and arousal index were measured and compared.
  
  
  RESULTS
  In group 1, after T&A, 48% continued to have an elevated AHI. If hypercarbia and hypoxemia are included in the result analysis, 67% continued to have abnormal PSG's after their surgery. In group 2, 63% had an elevated AHI post-operatively. When hypercarbia and hypoxemia are included in the analysis, 75% continued to have abnormal PSG's after surgery. There was no statistically significant difference in the outcome of the two groups.
  
  
  CONCLUSIONS
  Pediatric patients with OSAS and DS may show improvement after T&A, however only about one third will have a normal post-operative sleep study. Adding a lateral pharyngoplasty does not improve these results. Further study with objective outcome data is needed to determine a better first line surgical treatment for these patients.
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, University of Cincinnati, Ohio, USA.
authors.forename: James A
authors.initials: JA
authors.lastname: Merrell
authors.forename: Sally R
authors.initials: SR
authors.lastname: Shott
mesh_terms: D000233:Adenoidectomy / Q000379:methods*; D001049:Apnea / Q000175:diagnosis / Q000453:epidemiology; D001143:Arousal / Q000502:physiology; D002675:Child, Preschool; D004314:Down Syndrome / Q000453:epidemiology*; D005260:Female; D006801:Humans; D000860:Hypoxia / Q000175:diagnosis / Q000453:epidemiology; D008297:Male; D013517:Otorhinolaryngologic Surgical Procedures; D010614:Pharynx / Q000473:pathology* / Q000601:surgery*; D017286:Polysomnography; D012189:Retrospective Studies; D020181:Sleep Apnea, Obstructive / Q000175:diagnosis / Q000453:epidemiology* / Q000601:surgery*; D014068:Tonsillectomy / Q000379:methods*