SUMO and NF-kappaB ties.
Members of the NF-kappaB family of transcription factors play critical roles in regulating immunity and cell survival and contribute to cancer progression and chemoresistance. Over the past 20 years, much has been learned about the remarkable complexity in regulation of NF-kappaB signaling. In particular, recent studies have added to our current understanding of the roles of a multitude of posttranslational modifications in this signaling system: these include phosphorylation, acetylation, nitrosylation, ubiquitination, neddylation and sumoylation. This review will highlight our current knowledge of the roles of sumoylation in regulating NF-kappaB signaling and functions and will address future perspectives.
Mabb
A M
AM
Program in Molecular and Cellular Pharmacology, Department of Pharmacology, University of Wisconsin, 301 Medical Sciences Center, 1300 University Avenue, Madison, WI 53706, USA.
Miyamoto
S
S
D000818:Animals; D004249:DNA Damage; D006801:Humans; D051550:I-kappa B Kinase / Q000502:physiology; D020672:I-kappa B Proteins / Q000502:physiology; D066298:In Vitro Techniques; D047908:Intracellular Signaling Peptides and Proteins / Q000502:physiology; D008954:Models, Biological; D000072000:NF-KappaB Inhibitor alpha; D016328:NF-kappa B / Q000502:physiology*; D015398:Signal Transduction; D025841:Small Ubiquitin-Related Modifier Proteins / Q000502:physiology*; D014158:Transcription, Genetic
D020672:I-kappa B Proteins; D047908:Intracellular Signaling Peptides and Proteins; D016328:NF-kappa B; C000606204:NFKBIA protein, human; D025841:Small Ubiquitin-Related Modifier Proteins; D000072000:NF-KappaB Inhibitor alpha; D051550:I-kappa B Kinase