Development of diabetes mellitus in two boys after the initiation of growth hormone therapy.
In addition to its growth promoting properties, growth hormone (GH) has anti-insulin effects that could cause hyperglycemia. Development of diabetes mellitus as a result of GH therapy has been an ever-present, albeit rarely reported, concern. This report is that of two adolescent boys who developed diabetes mellitus after the initiation of treatment with GH.
Sadeghi-Nejad
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Division of Pediatric Endocrinology and Metabolism, Tufts University School of Medicine, Tufts-New England Medical Center (Floating Hospital for Children), Boston, MA 02111, USA. asadeghi@tufts-nemc.org
D000293:Adolescent; D001786:Blood Glucose / Q000032:analysis; D001827:Body Height / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D003920:Diabetes Mellitus / Q000139:chemically induced*; D006442:Glycated Hemoglobin; D006130:Growth Disorders / Q000188:drug therapy*; D006454:Hemoglobins / Q000032:analysis; D019382:Human Growth Hormone / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008297:Male
D001786:Blood Glucose; D006442:Glycated Hemoglobin; D006454:Hemoglobins; D019382:Human Growth Hormone; C517652:hemoglobin A1c protein, human