Effect of GB virus C co-infection on response to generic HAART in African patients with HIV-1 clade C infection.
In 38 African AIDS patients initiating generic HAART, GB virus C (GBV-C) RNA-positive patients retained GBV-C viraemia during 52 weeks of HAART, had a faster decline in HIV viral load (P = 0.03), fewer opportunistic infections (14.3 versus 50%, P = 0.18), and suffered no serious adverse events (none versus 61%, P = 0.008) compared with patients without GBV-C. GBV-C co-infection may be associated with a beneficial effect on African AIDS patients treated with generic HAART.
Mosam
Anisa
A
Medical Bioethics Unit, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.
Sathar
Mahomed A
MA
Dawood
Halima
H
Cassol
Edana
E
Esterhuizen
Tonya M
TM
Coovadia
Hoosen M
HM
D017088:AIDS-Related Opportunistic Infections / Q000453:epidemiology; D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000453:epidemiology; D000328:Adult; D000349:Africa / Q000453:epidemiology; D023241:Antiretroviral Therapy, Highly Active / Q000379:methods*; D005260:Female; D018178:Flaviviridae Infections / Q000150:complications / Q000453:epidemiology*; D029407:GB virus C; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy* / Q000453:epidemiology; D015497:HIV-1; D006525:Hepatitis, Viral, Human / Q000150:complications / Q000453:epidemiology*; D006566:Herpesviridae Infections / Q000150:complications / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012367:RNA, Viral / Q000032:analysis; D012189:Retrospective Studies; D012514:Sarcoma, Kaposi / Q000150:complications / Q000453:epidemiology; D014766:Viremia / Q000150:complications / Q000453:epidemiology
D012367:RNA, Viral