title: [Phase I study of docetaxel combined with carboplatin in patients with non-small cell lung cancer].
abstract: OBJECTIVE
  To determine the maximum tolerated dose (MTU) and dose-limiting toxicity (DLT) of Docetaxel and Carboplatin in patients with non-small cell lung cancer.
  
  
  METHODS
  Docetaxel was given at escalating doses until MTD was determined from the initial dose of 65 mg/m2 to 75 mg/m2, 85 mg/ m2 on dl. Carboplatin was targeted to an area under the plasma concentration curve of 5 using Calver's equation on dl. The treatment cycle was repeated every 3 weeks.
  
  
  RESULTS
  16 patients received TXT and CBP for total of 54 courses (median four courses). Neutropenia was the dose-limiting toxicity. The MTD of TXT is 85 mg/m2.
  
  
  CONCLUSIONS
  We recommend TXT 75 mg/m2 on d1 and CBP with a target AUC of 5 on d1, 3weeks repeated for chemotherapy in naïve patients with NSCLC.
authors.affiliation: Department of Chemotherapy Center, Zhejiang Province Cancer Hospital, Hangzhou 310022, China. hzhzazlm@hotmail.com
authors.forename: Li-Ming
authors.initials: LM
authors.lastname: Zhu
authors.forename: Qiu-Yun
authors.initials: QY
authors.lastname: Li
authors.forename: Xin-Min
authors.initials: XM
authors.lastname: Yu
authors.forename: Shen-Ling
authors.initials: SL
authors.lastname: Ma
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D016190:Carboplatin / Q000008:administration & dosage / Q000009:adverse effects; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy*; D000077143:Docetaxel; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000139:chemically induced; D012074:Remission Induction; D043823:Taxoids / Q000008:administration & dosage / Q000009:adverse effects
chemical_list: D043823:Taxoids; D000077143:Docetaxel; D016190:Carboplatin