title: A systematic study of carboxylic acids in negative ion mode electrospray ionisation mass spectrometry providing a structural model for ion suppression.
abstract: We report a systematic investigation of the effects and structural requirements for ion suppression in negative ion mode electrospray ionisation mass spectrometry of a series of carboxylic acids and present a structural model rationalising ion suppression effects.
authors.affiliation: School of Biomedical and Molecular Sciences, The University of Surrey, Guildford, Surrey GU2 7XH, UK.
authors.forename: Mike N
authors.initials: MN
authors.lastname: Clifford
authors.forename: Violeta
authors.initials: V
authors.lastname: Lopez
authors.forename: Laure
authors.initials: L
authors.lastname: Poquet
authors.forename: Gary
authors.initials: G
authors.lastname: Williamson
authors.forename: Nikolai
authors.initials: N
authors.lastname: Kuhnert
mesh_terms: D019342:Acetic Acid / Q000737:chemistry; D002264:Carboxylic Acids / Q000032:analysis* / Q000737:chemistry; D007477:Ions; D000432:Methanol / Q000737:chemistry; D015394:Molecular Structure; D012996:Solutions / Q000737:chemistry; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods*; D014867:Water / Q000737:chemistry
chemical_list: D002264:Carboxylic Acids; D007477:Ions; D012996:Solutions; D014867:Water; D019342:Acetic Acid; D000432:Methanol