title: Changes in qnr prevalence and fluoroquinolone resistance in clinical isolates of Klebsiella pneumoniae and Enterobacter spp. collected from 1990 to 2005.
abstract: Clinical isolates of Klebsiella pneumoniae and Enterobacter spp. collected from 1990 through 2005 at a tertiary care center were studied for qnr genes. Isolates bearing these genes emerged in the mid-1990s, coinciding with the time of a rapid increase in fluoroquinolone resistance. Sixty percent of these isolates were ciprofloxacin susceptible by CLSI breakpoints.
authors.affiliation: Department of Clinical Microbiology and Infectious Diseases, Hadassah Ein-Kerem, Jerusalem, Israel. jstrahilevitz@hadassah.org.il
authors.forename: Jacob
authors.initials: J
authors.lastname: Strahilevitz
authors.forename: Dalia
authors.initials: D
authors.lastname: Engelstein
authors.forename: Amos
authors.initials: A
authors.lastname: Adler
authors.forename: Violeta
authors.initials: V
authors.lastname: Temper
authors.forename: Allon E
authors.initials: AE
authors.lastname: Moses
authors.forename: Colin
authors.initials: C
authors.lastname: Block
authors.forename: Ari
authors.initials: A
authors.lastname: Robicsek
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D016470:Bacteremia / Q000453:epidemiology* / Q000382:microbiology; D001426:Bacterial Proteins / Q000235:genetics*; D002939:Ciprofloxacin / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial / Q000235:genetics; D004754:Enterobacter / Q000145:classification / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification; D004756:Enterobacteriaceae Infections / Q000453:epidemiology / Q000382:microbiology; D006801:Humans; D007557:Israel / Q000453:epidemiology; D007710:Klebsiella Infections / Q000453:epidemiology / Q000382:microbiology; D007711:Klebsiella pneumoniae / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification; D008826:Microbial Sensitivity Tests / Q000592:standards; D015995:Prevalence
chemical_list: D000890:Anti-Infective Agents; D001426:Bacterial Proteins; C485385:Qnr protein, Klebsiella pneumoniae; D002939:Ciprofloxacin