Synthesis and properties of star oligo/poly(trimethylene carbonate)s with cholic acid moieties as cores.
Star oligo/poly(trimethylene carbonate)s with cholic acid moieties as cores were synthesized by ring-opening polymerization of trimethylene carbonate (TMC) initiated by cholic acid with hydroxyl groups. The molecular weights of the star oligomers/polymers were controlled by adjusting the feed ratio of the initiator cholic acid to the monomer TMC. The star oligo/poly(trimethylene carbonate)s were characterized by Fourier transform infrared spectroscopy (FT-IR), (1)H nuclear magnetic resonance spectroscopy ((1)H-NMR) and combined size-exclusion chromatography and multiangle laser light scattering (SEC-MALLS) analysis. The water contact angles of the star oligo/poly(trimethylene carbonate)s were measured. Using 3-(4,5 dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay, the star oligo/poly(trimethylene carbonate) was proved to have a low cytotoxicity. A microsphere drug-delivery system based on a star polymer was fabricated and its in vitro drug release property was studied.
Zou
Tao
T
Key Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan University, Wuhan 430072, P. R. China.
Li
Song-Lin
SL
Hu
Zhao-Yu
ZY
Cheng
Si-Xue
SX
Zhuo
Ren-Xi
RX
D000818:Animals; D001672:Biocompatible Materials; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D004146:Dioxanes / Q000737:chemistry* / Q000627:therapeutic use; D004337:Drug Carriers / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000633:toxicity; D005347:Fibroblasts / Q000166:cytology; D008863:Microspheres; D011108:Polymers / Q000737:chemistry* / Q000627:therapeutic use; D011241:Prednisone / Q000008:administration & dosage / Q000493:pharmacokinetics; D014867:Water
D001672:Biocompatible Materials; D004146:Dioxanes; D004337:Drug Carriers; D011108:Polymers; D014867:Water; C443643:trimethylene carbonate; D011241:Prednisone