title: Patient self-management of long-term oral anticoagulation in Switzerland.
abstract: Indications for oral anticoagulation (OAC) have increased in recent years. OAC requires frequent monitoring of the prothrombin time to keep the intensity within the therapeutic range and to minimise the risk for complications. Patient self-management (PSM) has been found to improve the quality of OAC. The present study aimed to investigate the first 330 patients performing PSM in Switzerland. A questionnaire was sent to all patients who followed a teaching program for PSM of OAC between 1998 and 2003. Moreover, family physicians were contacted and/or discharge letters were obtained from the hospitals or the treating physicians. During the study period 13 patients died. Out of the 300 patients providing information 254 (85%) still perform PSM. At least one INR determination per two weeks was done by 74% of the patients and 25% performed at least one INR measurement every 15-30 days. The median time spent within the individual INR target range was 72%. No thromboembolic complications occurred, however, among the 13 patients who died, 1 had myocardial infarction and 6 died of heart failure. When counting these events as arterial thromboembolic complications the frequency was 0.6 (95% CI: 0.3-1.3) per 100 patient-years. The frequency of major bleeding was 0.6 (95% CI: 0.2-1.3) per 100 patient-years. We conclude from this study investigating a real-world patient collective that PSM is suitable and safe for the patients identified by their family physicians and successfully trained by our training centre.
authors.affiliation: Division of Haematology and Central Haematology Laboratory, Kantonsspital Luzern, CH-6000 Luzern 16, Switzerland.
authors.forename: Jordan
authors.initials: J
authors.lastname: Fritschi
authors.forename: Pascale
authors.initials: P
authors.lastname: Raddatz-Müller
authors.forename: Pirmin
authors.initials: P
authors.lastname: Schmid
authors.forename: Walter A
authors.initials: WA
authors.lastname: Wuillemin
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000925:Anticoagulants / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D004522:Educational Status; D005260:Female; D006801:Humans; D019934:International Normalized Ratio; D008297:Male; D008875:Middle Aged; D010353:Patient Education as Topic; D015397:Program Evaluation; D012189:Retrospective Studies; D012648:Self Care; D011795:Surveys and Questionnaires; D013557:Switzerland; D013923:Thromboembolism / Q000188:drug therapy*; D013997:Time Factors
chemical_list: D000925:Anticoagulants