[Experience of treatment of patients with gastropathy induced by non-steroid anti-inflammatory drugs].
A complex study of 147 patients who were taking non-steroid anti-inflammatory drugs (NSAIDs) revealed gastric lesions in 120 patients (81.6%). H2 blocker (ranitidine) was used for treating 40 patients with NSAID-induced gastropathy, proton pump inhibitor (omeprazole) was used for 40 patients, and Gastrozepin combined with Misoprostol--for 40 patients. Pain syndrome and dyspepsia were eliminated in most of the patients as a result of the treatment. Using Gastrozepin and Misoprostol produced an active effect on the trophic processes in the gastric mucous coat and caused erosion and ulcer healing. As compared to ranitidine and omeprazole, Gastrozepin used in combination with Cytotec produces a lower effect on the reduction of the acid-producing stomach function, yet it has a considerably greater effect on the normalization of the gastric mucus structure and restoration of metabolism of the gastric mucous coat collagen.
Vakhrushev
Ia M
IaM
Loshchakova
O Iu
OIu
D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D015415:Biomarkers / Q000032:analysis / Q000097:blood; D004359:Drug Therapy, Combination; D005260:Female; D006635:Histamine H2 Antagonists / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D016595:Misoprostol / Q000627:therapeutic use; D009853:Omeprazole / Q000627:therapeutic use; D010890:Pirenzepine / Q000627:therapeutic use; D011899:Ranitidine / Q000627:therapeutic use; D013272:Stomach Diseases / Q000139:chemically induced / Q000175:diagnosis / Q000188:drug therapy*; D016896:Treatment Outcome
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000897:Anti-Ulcer Agents; D015415:Biomarkers; D006635:Histamine H2 Antagonists; D016595:Misoprostol; D010890:Pirenzepine; D011899:Ranitidine; D009853:Omeprazole