Immunosuppressive lignans isolated from Saururus chinensis.
Bioactivity-guided fractionation of Saururus chinensis (Saururaceae) using a lymphoproliferation assay led us to isolate 5 lignans (compounds 1 - 5). Compounds 1 - 5 were identified as sauchinone, (-)-saucerneol, saucerneol C, manassantin A, and manassantin B, respectively, by spectroscopic analyses. The immunosuppressive activities of the active compounds were evaluated using lymphoproliferation, mixed leukocyte response, and Th1/Th2 cytokine assays. The relative potency was in the order: manassantin A, B > (-)-saucerneol > saucerneol C > sauchinone.
Park
Shin-Young
SY
Korea Institute of Toxicology, Daejeon, Korea.
Lee
Sung Hak
SH
Choi
Woo Hyuck
WH
Koh
Eun Mi
EM
Seo
Jee Hee
JH
Ryu
Shi Yong
SY
Kim
Young Sup
YS
Kwon
Dae Young
DY
Koh
Woo Suk
WS
D049109:Cell Proliferation / Q000187:drug effects; D016207:Cytokines / Q000378:metabolism; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D017705:Lignans / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D007959:Lymphocyte Culture Test, Mixed; D008214:Lymphocytes / Q000187:drug effects* / Q000378:metabolism*; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D032134:Saururaceae
D016207:Cytokines; D007166:Immunosuppressive Agents; D017705:Lignans; D010936:Plant Extracts