Molecular characterization of the equine herpesvirus 1 strains RacL11 and Kentucky D.
The pathogenicities of RacL11 and Kentucky D strains of equine herpesvirus 1 in the hamster infection model are different from those of Ab4p and the Japanese isolates. Virus genome restriction fragment length polymorphism analysis and sequence comparison of an intergenic region, glycoproteins and tegument genes showed higher conservation but with some strain-specific differences. These results indicate that point nucleotide differences in RacL11 and Kentucky D might be responsible for their pathogenicity in rodent models.
Ghanem
Yasser M
YM
Department of Applied Veterinary Sciences, United Graduate School of Veterinary Sciences, Gifu University, Yanagido, Gifu, Japan.
Ibrahim
El-Sayed M
el-SM
Yamada
Souichi
S
Matsumura
Tomio
T
Osterrieder
Nikolaus
N
Yamaguchi
Tsuyoshi
T
Fukushi
Hideto
H
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D017124:Conserved Sequence / Q000235:genetics; D006224:Cricetinae; D005814:Genes, Viral / Q000235:genetics*; D014644:Genetic Variation; D004861:Herpesvirus 1, Equid / Q000235:genetics* / Q000472:pathogenicity; D008969:Molecular Sequence Data; D012150:Polymorphism, Restriction Fragment Length; D017422:Sequence Analysis, DNA; D013045:Species Specificity