[Preparation and characterization of chitosan coated puerarin liposomes].
OBJECTIVE
To prepare chitosan coated puerarin liposomes and investigate their physicochemical properties.


METHODS
Puerarin liposomes were prepared by reverse phase evaporation technique and then coated with chitosan. Using encapsulation efficiency as index of examination and designing an orthogonal experiment, the optimal formulation of liposomes was determined. The physicochemical properties of uncoatd and chitosan coated puerarin liposomes were investigated, respectively.


RESULTS
Uncoated and chitosan coated puerarin liposomes were spherelike and smooth. The mean particles size of uncoated and coated liposomes were 217. 3nm and 632. 6nm, respectively. The Zeta potential were -14.44 mV and +35.61 mV, respectively. The encapsulating efficency was 50. 6% and 51.1%, respectively.


CONCLUSIONS
Puerarin liposomes can be prepared by reverse phase evaporation technique successfully. The chitosan coated purarin liposomes ware spherelike and smooth.
Wang
Hai-gang
HG
School of Pharmacy, Shandong University, Jinan 250012, China. wanghaigan-200@163.com
Zhai
Guang-xi
GX
Lü
Qing-zhi
QZ
Ling
Pei-xue
PX
D048271:Chitosan / Q000737:chemistry*; D004337:Drug Carriers; D004355:Drug Stability; D007887:Fabaceae / Q000737:chemistry*; D007529:Isoflavones / Q000008:administration & dosage* / Q000737:chemistry; D008081:Liposomes / Q000737:chemistry; D010316:Particle Size; D010946:Plants, Medicinal / Q000737:chemistry; D013678:Technology, Pharmaceutical / Q000379:methods*
D004337:Drug Carriers; D007529:Isoflavones; D008081:Liposomes; D048271:Chitosan; C033607:puerarin