title: Highly enantioselective conjugate addition of thiols using mild scandium triflate catalysis.
abstract: A Sc complex of (4S,5S)-diphenyl PYBOX 1 was found to serve as a catalyst for the asymmetric conjugate addition reactions between various thiols and 3-crotonoyl-2-oxazolidinone, affording the corresponding adducts in good yields and high enantioselectivies (up to 92% ee). A new improved method for making (4S,5S)-diphenyl PYBOX is presented.
authors.affiliation: Laboratory of Organic Chemistry, Helsinki University of Technology, P.O.B. 6100, FI-02015 TKK, Finland.
authors.forename: Aki M M
authors.initials: AM
authors.lastname: Abe
authors.forename: Sami J K
authors.initials: SJ
authors.lastname: Sauerland
authors.forename: Ari M P
authors.initials: AM
authors.lastname: Koskinen