[Small-cell lung cancer diagnostic and therapeutic recommendations of Polish Lung Cancer Group].
Small-cell lung cancer is characterized by an aggressive clinical course with high tendency for early dissemination. At presentation, patients are usually symptomatic and with hilar or mediastinal mass at radiography. Staging should be focused on identifying any evidence of distant spread. Chemotherapy including cisplatin and etoposide is a cornerstone of treatment for all patients. Limited-stage disease should be managed by chemotherapy combined with concurrent chest irradiation. All patients who achieve complete response should be considered for elective cranial irradiation. Surgical treatment may be used in highly selected patients with TNM stage I disease, and surgery should always be combined with chemotherapy. Extensive-stage disease should be managed by multi-agent chemotherapy alone. Long-term survivors should undergo careful monitoring for development of a second primary tumour.
Krzakowski
Maciej
M
Centrum Onkologii -- Instytut w Warszawie. maciekk@coi.waw.pl
Orłowski
Tadeusz
T
Roszkowski
Kazimierz
K
Reinfuss
Marian
M
Olszewski
Włodzimierz
W
Ramlau
Rodryg
R
Kowalski
Dariusz
D
Konopa
Krzysztof
K
Jassem
Jacek
J
Jankowska
Renata
R
Kozielski
Jerzy
J
Wojtukiewicz
Marek
M
Drosik
Kazimierz
K
Koralewski
Piotr
P
D000970:Antineoplastic Agents; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000532:radiotherapy / Q000556:secondary; D018288:Carcinoma, Small Cell / Q000175:diagnosis* / Q000473:pathology / Q000556:secondary / Q000628:therapy*; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy / Q000592:standards; D005047:Etoposide / Q000008:administration & dosage; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy*; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control; D009367:Neoplasm Staging; D009378:Neoplasms, Multiple Primary / Q000517:prevention & control; D011013:Pneumonectomy; D011379:Prognosis; D012074:Remission Induction
D000970:Antineoplastic Agents; D005047:Etoposide; D002945:Cisplatin