title: The role of surgery in high-grade glioma--is surgical resection justified? A review of the current knowledge.
abstract: BACKGROUND
  The aims of this article were to review the role of surgical resection in the management of high-grade gliomas and to determine whether there is any survival benefit from surgical resection.
  
  
  METHODS
  A literature review of the influence of surgical resection on outcome was carried out. Relevant original and review papers were obtained through a PubMed search using the following keywords: glioma, resection, prognosis and outcome.
  
  
  RESULTS
  Presently, there is a lack of evidence to support a survival benefit with aggressive glioma resection, but this should not detract patients from undergoing surgery as there are many other clinical benefits of glioma excision. In addition, limiting surgical morbidity through the use of adjuvant techniques such as intraoperative magnetic resonance imaging (MRI), functional MRI and awake craniotomy is becoming increasingly important.
  
  
  CONCLUSIONS
  Ideally, a randomised controlled trial would be the best way to resolve the issue of whether (and to what extent) surgical resection leads to improvements in patient outcome and survival, but this would not be ethical. The second best option would be well-controlled retrospective studies with a multivariate analysis of all potential confounding factors.
authors.affiliation: Department of Neurosurgery, National Neuroscience Institute, 11 Jalan Tan Tock Seng, Singapore 308433.
authors.forename: Boon-Chuan
authors.initials: BC
authors.lastname: Pang
authors.forename: Wei-Hwang
authors.initials: WH
authors.lastname: Wan
authors.forename: Cheng-Kiang
authors.initials: CK
authors.lastname: Lee
authors.forename: Kathleen Joy
authors.initials: KJ
authors.lastname: Khu
authors.forename: Wai-Hoe
authors.initials: WH
authors.lastname: Ng
mesh_terms: D005910:Glioma / Q000145:classification / Q000601:surgery*; D006801:Humans; D012846:Singapore; D016019:Survival Analysis