Etnangien, a macrolide-polyene antibiotic from Sorangium cellulosum that inhibits nucleic acid polymerases.
Etnangien (1), a new macrolide antibiotic active against Gram-positive bacteria, was isolated from the culture broth of the myxobacterium Sorangium cellulosum, strains So ce750 and So ce1045. Spectroscopic structure elucidation of 1 revealed a complex macrocyclic lactone bearing a modified C21 carboxylic acid side chain. The latter contains two allylic hydroxyl groups and an all-E hexaene unit, which provides the characteristic UV chromophore of 1. Initial studies toward the mechanism of action showed that bacterial and viral nucleic acid polymerases are inhibited by etnangien (1).
Irschik
Herbert
H
Research Group Microbial Drugs, Helmholtz Centre for Infection Research (HZI), Inhoffenstrasse 7, 38124 Braunschweig, Germany.
Schummer
Dietmar
D
Höfle
Gerhard
G
Reichenbach
Hans
H
Steinmetz
Heinrich
H
Jansen
Rolf
R
D004926:Escherichia coli / Q000187:drug effects / Q000201:enzymology; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D009052:Leukemia Virus, Murine / Q000187:drug effects / Q000201:enzymology; D018942:Macrolides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015394:Molecular Structure; D009231:Myxococcales / Q000737:chemistry*; D009713:Nucleotidyltransferases / Q000037:antagonists & inhibitors*; D011090:Polyenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
D018942:Macrolides; D011090:Polyenes; C521655:etnangien; D009713:Nucleotidyltransferases