Ethnic differences in adrenocorticotropic hormone, cortisol and corticotropin-releasing hormone during pregnancy.
Significant ethnic disparities exist in reproductive outcomes. A potential contributing factor may be the functioning of the hypothalamic-pituitary-adrenal (HPA) axis and placenta during pregnancy. In the present study, levels of cortisol, ACTH and CRH were determined longitudinally from the plasma of 310 African American, Hispanic and non-Hispanic White women at 18-20, 24-26 and 30-32 weeks' gestation. During pregnancy, African American women exhibited lower levels of cortisol than non-Hispanic women and higher levels of ACTH than Hispanic women. The trajectory of CRH increase also differed by ethnicity, with African Americans exhibiting the lowest levels both early and late in pregnancy. Higher levels of cortisol at 18-20 weeks were associated with higher levels of CRH at 30-32 weeks among the African American and Hispanic women, but not among non-Hispanic women. Ethnic differences persisted when adjusting statistically for sociodemographic and biomedical factors. The findings are consistent with the possibility that ethnic disparities in adverse birth outcomes may be due, in part, to differences in HPA axis and placental function.
Glynn
Laura M
LM
Department of Psychiatry & Human Behavior, University of California, Irvine, CA 92868, United States. lglynn@uci.edu
Schetter
Christine Dunkel
CD
Chicz-DeMet
Aleksandra
A
Hobel
Calvin J
CJ
Sandman
Curt A
CA
D000324:Adrenocorticotropic Hormone / Q000097:blood*; D001741:Black or African American; D044383:Black People; D003346:Corticotropin-Releasing Hormone / Q000097:blood*; D005260:Female; D005865:Gestational Age; D006630:Hispanic or Latino; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011262:Pregnancy Trimester, Second; D011263:Pregnancy Trimester, Third; D044465:White People
D000324:Adrenocorticotropic Hormone; D003346:Corticotropin-Releasing Hormone; D006854:Hydrocortisone