Endoscopic ultrasound-guided interstitial chemotherapy in the pancreas: results in a canine model.
OBJECTIVE
Interstitial chemotherapy using surgically implanted, biodegradable polymers has been reported. Our aim in this study was to investigate the feasibility and safety of endoscopic ultrasound- (EUS-) guided interstitial chemotherapy of the pancreas in a canine model.


METHODS
A therapeutic 19-gauge needle with a large channel was inserted into the pancreas under EUS guidance. The polymers for sustained intratumoral release of 5-fluorouracil were implanted into the tissue by the needle. After 14 days of clinical observation, the animals were sacrificed and the tissue response to the local chemotherapy was examined.


RESULTS
All the polymers were implanted successfully and no implant migration occurred. Localized tissue fibrous necrosis was achieved in the pancreas, without significant complications. The apoptotic index of the tissue within 1 cm of the focus increased. Biochemical parameters were normal in all the dogs.


CONCLUSIONS
EUS-guided implantation of polymers is a safe, simple, and minimally invasive technique for interstitial chemotherapy in the pancreas.
Sun
S
S
Endoscopy Center, Shengjing Hospital, China Medical University, Shenyang, Liaoning Province, China. Sunsy@cmu2h.com
Wang
S
S
Ge
N
N
Lei
T
T
Lu
Q
Q
Zhou
Z
Z
Yang
A
A
Wang
Z
Z
Sun
M
M
D000818:Animals; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage*; D004285:Dogs; D019160:Endosonography; D005240:Feasibility Studies; D005472:Fluorouracil / Q000008:administration & dosage*; D015552:Injections, Intralesional; D023421:Models, Animal; D010179:Pancreas / Q000000981:diagnostic imaging* / Q000473:pathology; D011108:Polymers / Q000008:administration & dosage
D000964:Antimetabolites, Antineoplastic; D011108:Polymers; D005472:Fluorouracil