T-cell co-stimulatory molecules: their role in allergic immune reactions.
The development of allergic diseases, such as allergic asthma, depends upon the initiation and maintenance of T-helper cell type-2-skewed allergen-specific immune reactions. Although it is clear that susceptibility to this process is under genetic and environmental control, the fine-tuning and regulation of the type-2 T-helper cell immune response is not yet fully understood. In this second article in the present series, current understanding regarding the involvement of T-cells and antigen-presenting cells is summarised, with emphasis on the interaction between these two types of immune regulatory cells by means of co-stimulatory molecules.
Kallinich
T
T
Department of Paediatrics, Division of Pneumology and Immunology, Charité Medical University of Berlin, Campus Virchow-Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany.
Beier
K C
KC
Wahn
U
U
Stock
P
P
Hamelmann
E
E
D000818:Animals; D001249:Asthma / Q000378:metabolism; D001992:Bronchoalveolar Lavage Fluid; D002454:Cell Differentiation; D020022:Genetic Predisposition to Disease; D006801:Humans; D006967:Hypersensitivity / Q000097:blood / Q000276:immunology*; D007107:Immune System; D007249:Inflammation; D051379:Mice; D010641:Phenotype; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D018418:Th2 Cells / Q000276:immunology*