title: [Effects of ischemia on olfactory bulb in rats].
abstract: OBJECTIVE
  To observe the olfactory bulb's morphological change after ischemic injury in rats, and explore the role of vascular factor in olfactory disorders.
  
  
  METHODS
  Forty adult SD rats (weighting 250-300 g) were used, 30 of which were treated with permanent bilateral occlusion of both common carotid arteries, and the others were served as the control. The olfactory bulbs were carefully taken out on the 1st week, 4th week, 2nd month post operation, respectively, then observed the morphological changes by light microscopy. The ultra structure of cells in olfactory bulbs were also observed by transmission electron microscope.
  
  
  RESULTS
  In rats with permanent bilateral occlusion of both common carotid arteries, the vascular pattern changed and the cell number decreased in olfactory bulbs by light microscopy. In the 1st week group, the mitral cells' mitochondria injury and metamorphism were found. In the 4th week group, the microvascular paramorphia, lipofuscin in mitral cells and metamorphic nerve fibers were found by transmission electron microscope.
  
  
  CONCLUSIONS
  Ischemia could injure the neuron and nerve fiber. This may be one of the reasons of olfactory disorders.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Beijing Tongren Hospital Affiliated to Capital University of Medical Sciences,Beijing, 100730, China.
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Zhan
authors.forename: Yongxiang
authors.initials: Y
authors.lastname: Wei
authors.forename: Xutao
authors.initials: X
authors.lastname: Miao
authors.forename: Cong
authors.initials: C
authors.lastname: Zhang
authors.forename: Demin
authors.initials: D
authors.lastname: Han
mesh_terms: D000818:Animals; D007511:Ischemia / Q000473:pathology*; D046529:Microscopy, Electron, Transmission; D009474:Neurons / Q000473:pathology / Q000648:ultrastructure; D009830:Olfactory Bulb / Q000166:cytology* / Q000473:pathology*; D051381:Rats; D017207:Rats, Sprague-Dawley