title: 4849F, a new metabolite produced by the Streptomyces sp. 4849 as an inhibitor of IL-4 receptor.
abstract: A new compound named 4849F was isolated from the Streptomyces sp. 4849. The structure of 4849F was elucidated by spectroscopic analyses. The immobilized ligand-binding assay showed that 4849F can competitively inhibit the binding of IL-4 with IL-4 receptor in a dose dependent manner with an IC50 value of 6.7 microM.
authors.affiliation: Institute of Medicinal Biotechnology, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China.
authors.forename: Ke
authors.initials: K
authors.lastname: Wang
authors.forename: Lianhong
authors.initials: L
authors.lastname: Guo
authors.forename: Yingshu
authors.initials: Y
authors.lastname: Zou
authors.forename: Yuan
authors.initials: Y
authors.lastname: Li
authors.forename: Jianbo
authors.initials: J
authors.lastname: Wu
mesh_terms: D055598:Chemical Phenomena; D002627:Chemistry, Physical; D006094:Gram-Positive Bacteria / Q000187:drug effects; D015847:Interleukin-4 / Q000378:metabolism; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D011724:Pyridazines / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D019948:Receptors, Interleukin-4 / Q000037:antagonists & inhibitors*; D013056:Spectrophotometry, Ultraviolet; D013302:Streptomyces / Q000737:chemistry*; D013778:Tetrazolium Salts; D013844:Thiazoles
chemical_list: C522439:4849F compound; D008024:Ligands; D011724:Pyridazines; D019948:Receptors, Interleukin-4; D013778:Tetrazolium Salts; D013844:Thiazoles; D015847:Interleukin-4; C022616:thiazolyl blue