title: Patterns of expression of the Follistatin and Follistatin-like1 genes during chicken heart development: a potential role in valvulogenesis and late heart muscle cell formation.
abstract: The regulation of concentration and function of growth factors is of crucial importance to proper embryonic development of the heart. The patterns of expression of three extracellular modulators of the transforming growth factor-beta superfamily of growth factors, Follistatin, Follistatin-like1, and Follistatin-like3, are described with respect to heart development. Follistatin is highly localized in the endocardium covering the developing cardiac valves. Follistatin-like1 is localized in the mesenchymal filling of the pharyngeal arches and broadly expressed in cells directly bordering myocardium. Follistatin-like3 is not expressed in the heart. Taken together, these observations are suggestive for a role for Follistatin in cardiac valvulogenesis and a role for Follistatin-like1 in controlling late heart muscle cell formation.
authors.affiliation: Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
authors.forename: Gert
authors.initials: G
authors.lastname: van den Berg
authors.forename: Semir
authors.initials: S
authors.lastname: Somi
authors.forename: Anita A M
authors.initials: AA
authors.lastname: Buffing
authors.forename: Antoon F M
authors.initials: AF
authors.lastname: Moorman
authors.forename: Maurice J B
authors.initials: MJ
authors.lastname: van den Hoff
mesh_terms: D000818:Animals; D001934:Branchial Region / Q000196:embryology / Q000378:metabolism; D002642:Chick Embryo; D004699:Endocardium / Q000196:embryology / Q000378:metabolism; D038681:Follistatin / Q000235:genetics / Q000378:metabolism*; D038702:Follistatin-Related Proteins / Q000235:genetics / Q000378:metabolism*; D018507:Gene Expression Regulation, Developmental; D005865:Gestational Age; D006321:Heart / Q000196:embryology*; D006351:Heart Valves / Q000196:embryology / Q000378:metabolism; D017403:In Situ Hybridization; D024510:Muscle Development / Q000235:genetics; D009206:Myocardium / Q000166:cytology / Q000378:metabolism*; D032383:Myocytes, Cardiac / Q000378:metabolism; D038081:Organogenesis / Q000235:genetics; D012333:RNA, Messenger / Q000378:metabolism
chemical_list: D038681:Follistatin; D038702:Follistatin-Related Proteins; D012333:RNA, Messenger