Antimicrobial activity of rationally designed amino terminal modified peptides.
Series of short amino terminal modified cationic peptides were designed and synthesized. All of the synthesized compounds were tested against gram-positive as well as gram-negative bacterial strain. Some of the compounds exhibit potent antibacterial activity and no hemolytic activity even at high dose level (1000 microg/mL) in mammalian erythrocytes was observed.
Bisht
Gopal Singh
GS
Peptide Research Laboratory, Institute of Genomics and Integrative Biology, Mall Road, Delhi 110007, India.
Rawat
Diwan S
DS
Kumar
Anil
A
Kumar
Rita
R
Pasha
Santosh
S
D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D010455:Peptides / Q000737:chemistry* / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D010455:Peptides