title: A mathematical model for bone tissue regeneration inside a specific type of scaffold.
abstract: Bone tissue regeneration using scaffolds is receiving an increasing interest in orthopedic surgery and tissue engineering applications. In this study, we present the geometrical characterization of a specific family of scaffolds based on a face cubic centered (FCC) arrangement of empty pores leading to analytical formulae of porosity and specific surface. The effective behavior of those scaffolds, in terms of mechanical properties and permeability, is evaluated through the asymptotic homogenization theory applied to a representative volume element identified with the unit cell FCC. Bone growth into the scaffold is estimated by means of a phenomenological model that considers a macroscopic effective stress as the mechanical stimulus that regulates bone formation. Cell migration within the scaffold is modeled as a diffusion process based on Fick's law which allows us to estimate the cell invasion into the scaffold microstructure. The proposed model considers that bone growth velocity is proportional to the concentration of cells and regulated by the mechanical stimulus. This model allows us to explore what happens within the scaffold, the surrounding bone and their interaction. The mathematical model has been numerically implemented and qualitatively compared with previous experimental results found in the literature for a scaffold implanted in the femoral condyle of a rabbit. Specifically, the model predicts around 19 and 23% of bone regeneration for non-grafted and grafted scaffolds, respectively, both with an initial porosity of 76%.
authors.affiliation: Group of Structural Mechanics and Materials Modelling, Aragón Institute of Engineering Research (I3A), University of Zaragoza, C/María de Luna 5, Agustín de Betancourt Building, 50018 Zaragoza, Spain.
authors.forename: J A
authors.initials: JA
authors.lastname: Sanz-Herrera
authors.forename: J M
authors.initials: JM
authors.lastname: Garcia-Aznar
authors.forename: M
authors.initials: M
authors.lastname: Doblare
mesh_terms: D000818:Animals; D001846:Bone Development / Q000502:physiology; D001861:Bone Regeneration / Q000502:physiology*; D001842:Bone and Bones / Q000502:physiology*; D005269:Femur / Q000502:physiology; D008954:Models, Biological; D008962:Models, Theoretical; D010012:Osteogenesis / Q000502:physiology*; D016062:Porosity; D011817:Rabbits; D013314:Stress, Mechanical; D013997:Time Factors; D023822:Tissue Engineering / Q000379:methods; D054457:Tissue Scaffolds