title: Choroidal microcirculation in patients with rotary cardiac assist device.
abstract: BACKGROUND
  In recent years, fully implanted rotary blood pumps have been used for long-term cardiac assist in patients with end-stage heart failure. With these pumps, the pulsatility of arterial blood flow and arterial pressure pulse is considerably reduced. Effects on end-organ perfusion, particularly microcirculation, have been assessed.
  
  
  METHODS
  The ocular choroid offers a unique opportunity to study the pulsatile component of blood flow by measurement of fundus pulsation amplitude (FPA) as well as the microcirculation by laser Doppler flowmetry. Both techniques were applied in three male patients with rotary pumps (MicroMed DeBakey VAD), in whom pump velocity was adjusted to four levels of flow between individual minimal need and maximal support. In addition, blood flow velocities in the ophthalmic artery (peak, end-diastolic and mean flow velocity--PSV, EDV and MFV, respectively) were measured using color Doppler imaging.
  
  
  RESULTS
  Systolic blood pressure increased by 6 to 22 mm Hg with increasing support. At maximal support FPA was reduced by -60% to -52% as compared with minimal pump support. Blood flow in the choroidal microvasculature, however, did not show relevant changes. A reduction in PSV (-31%, range -47% to -21%) and a pronounced rise in EDV (+93%, range +28% to +147%) was observed, whereas MFV was independent of pump flow.
  
  
  CONCLUSIONS
  Our data indicate that mean choroidal blood flow is maintained when pump support is varied within therapeutic values, whereas the ratio of pulsatile to non-pulsatile choroidal flow changes. This study shows that, in patients with ventricular assist devices, a normal perfusion rate in the ocular microcirculation is maintained over a wide range of support conditions.
authors.affiliation: Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria.
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Polska
authors.forename: Heinrich
authors.initials: H
authors.lastname: Schima
authors.forename: Georg
authors.initials: G
authors.lastname: Wieselthaler
authors.forename: Leopold
authors.initials: L
authors.lastname: Schmetterer
mesh_terms: D000368:Aged; D001794:Blood Pressure; D002829:Choroid / Q000098:blood supply* / Q000000981:diagnostic imaging; D005260:Female; D005500:Follow-Up Studies; D006353:Heart-Assist Devices; D006801:Humans; D008297:Male; D008833:Microcirculation / Q000502:physiology*; D018615:Ultrasonography, Doppler, Color