Improved antimicrobial peptides based on acyl-lysine oligomers.
We describe peptidomimetic oligomers that show rapid, nonhemolytic, broad-spectrum bactericidal properties in mice and do not induce the emergence of resistance. The oligomers contain acyl chains, which prevent the formation of stable secondary structure. This design appears advantageous over conventional antimicrobial peptides with respect to in vivo efficacy and safety, and may provide a convenient platform for the development of peptide antibiotics.
Radzishevsky
Inna S
IS
Department of Biotechnology & Food Engineering, Technion-Israel Institute of Technology, Haifa 32000, Israel.
Rotem
Shahar
S
Bourdetsky
Dmitry
D
Navon-Venezia
Shiri
S
Carmeli
Yehuda
Y
Mor
Amram
A
D000818:Animals; D023181:Antimicrobial Cationic Peptides / Q000008:administration & dosage* / Q000737:chemistry*; D019281:Dimerization; D015195:Drug Design; D007274:Injections, Intraperitoneal; D008239:Lysine / Q000737:chemistry*; D051379:Mice; D010538:Peritonitis / Q000175:diagnosis / Q000188:drug therapy*; D016896:Treatment Outcome
D023181:Antimicrobial Cationic Peptides; D008239:Lysine