After hours keeps clock researchers CRYing Overtime.
Three recent reports, including one in this issue of Cell, reveal that the circadian regulator CRY is targeted for degradation by the F box E3 ubiquitin ligase FBXL3 (Siepka et al., 2007; Busino et al., 2007; Godinho et al., 2007). These studies confirm the importance of targeted protein degradation as a key design feature of the mammalian circadian clock.
Virshup
David M
DM
Department of Pediatrics and the Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA. david.virshup@hci.utah.edu
Forger
Daniel B
DB
D000818:Animals; D001683:Biological Clocks; D021081:Chronobiology Disorders; D002940:Circadian Rhythm; D056931:Cryptochromes; D044783:F-Box Proteins / Q000235:genetics* / Q000378:metabolism*; D005420:Flavoproteins / Q000378:metabolism*; D009154:Mutation; D009687:Nuclear Proteins / Q000378:metabolism; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism
D056931:Cryptochromes; D044783:F-Box Proteins; D005420:Flavoproteins; D009687:Nuclear Proteins; D044767:Ubiquitin-Protein Ligases