Meloxicam, an inhibitor of cyclooxygenase-2, increases the level of serum G-CSF and might be usable as an auxiliary means in G-CSF therapy.
Hematopoiesis-modulating action of meloxicam, a cyclooxyge-nase-2 inhibitor, has been evaluated in mice. Increased serum level of granulocyte colony-stimulating factor (G-CSF) after meloxicam administration has been found in sublethally gamma-irradiated animals. In further experiments hematopoiesis-stimulating effects of meloxicam and G-CSF given alone or in combination have been investigated. Granulocyte/macrophage progenitor cells counts were used to monitor these effects. Meloxicam and exogenous G-CSF did not act synergistically when given in combination, but could be mutually substituted during their repeated administration. The results suggest a promising possibility of using meloxicam as an auxiliary drug reducing the high costs of G-CSF therapy of myelosuppression.
Hofer
M
M
Laboratory of Experimental Hematology, Institute of Biophysics, Academy of Sciences of the Czech Republic, Brno, Czech Republic. hofer@ibp.cz
Pospíšil
M
M
Znojil
V
V
Holá
J
J
Vacek
A
A
Štreitová
D
D
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects* / Q000528:radiation effects; D002454:Cell Differentiation; D052246:Cyclooxygenase 2 Inhibitors / Q000494:pharmacology*; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage / Q000097:blood* / Q000187:drug effects; D006098:Granulocytes / Q000166:cytology / Q000187:drug effects / Q000528:radiation effects; D006410:Hematopoiesis / Q000187:drug effects*; D007970:Leukopenia / Q000517:prevention & control; D008297:Male; D000077239:Meloxicam; D051379:Mice; D008808:Mice, Inbred CBA; D013843:Thiazines / Q000494:pharmacology*; D013844:Thiazoles / Q000494:pharmacology*; D014916:Whole-Body Irradiation
D052246:Cyclooxygenase 2 Inhibitors; D013843:Thiazines; D013844:Thiazoles; D016179:Granulocyte Colony-Stimulating Factor; D000077239:Meloxicam