[Gene-environment interactions in the pathogenesis and prevention of type 2 diabetes mellitus].
Type 2 diabetes mellitus is a chronic progressive disease characterized by impaired insulin secretion of the beta cell and impaired insulin sensitivity of different tissues. The incidence of type 2 diabetes mellitus is increasing worldwide, and the disease has reached epidemic proportions. Lifestyle intervention programs are able to delay or possibly prevent the manifestation of type 2 diabetes mellitus. This review summarizes the genetic and environmental factors which influence the risk for type 2 diabetes and their interactions, and determine the success of prevention programs.
Fritsche
A
A
Abt. Innere Medizin IV, Universitätsklinikum Tübingen. andreas.fritsche@med.uni-tuebingen.de
Thamer
C
C
Stefan
N
N
Häring
H U
HU
D001823:Body Composition; D015992:Body Mass Index; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics* / Q000517:prevention & control / Q000628:therapy; D003925:Diabetic Angiopathies / Q000235:genetics / Q000517:prevention & control / Q000628:therapy; D005247:Feeding Behavior; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D007333:Insulin Resistance / Q000235:genetics; D008019:Life Style; D009765:Obesity / Q000150:complications; D010641:Phenotype; D011110:Polymorphism, Genetic / Q000235:genetics; D012307:Risk Factors; D012931:Social Environment