title: Adaptive deformable model for colonic polyp segmentation and measurement on CT colonography.
abstract: Polyp size is one important biomarker for the malignancy risk of a polyp. This paper presents an improved approach for colonic polyp segmentation and measurement on CT colonography images. The method is based on a combination of knowledge-guided intensity adjustment, fuzzy clustering, and adaptive deformable model. Since polyps on haustral folds are the most difficult to be segmented, we propose a dual-distance algorithm to first identify voxels on the folds, and then introduce a counter-force to control the model evolution. We derive linear and volumetric measurements from the segmentation. The experiment was conducted on 395 patients with 83 polyps, of which 43 polyps were on haustral folds. The results were validated against manual measurement from the optical colonoscopy and the CT colonography. The paired t-test showed no significant difference, and the R(2) correlation was 0.61 for the linear measurement and 0.98 for the volumetric measurement. The mean Dice coefficient for volume overlap between automatic and manual segmentation was 0.752 (standard deviation 0.154).
authors.affiliation: Diagnostic Radiology Department, Clinical Center National Institutes of Health, Bethesda, Maryland 20892, USA.
authors.forename: Jianhua
authors.initials: J
authors.lastname: Yao
authors.forename: Ronald M
authors.initials: RM
authors.lastname: Summers
mesh_terms: D003111:Colonic Polyps / Q000000981:diagnostic imaging*; D023881:Colonography, Computed Tomographic / Q000379:methods*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D010363:Pattern Recognition, Automated / Q000379:methods*