Preparation of the traditional Chinese medicine compound recipe Shuxiong sustained-release capsules by multiparticulate time-controlled explosion technology.
In this study the traditional Chinese medicine compound recipe (TCMCR) Shuxiong sustained-release capsules (SXSRC) were prepared by multiparticulate time-controlled explosion technology. First, Shuxiong pellets were prepared with the refined medicinal materials containing in the recipe of Shuxiong tablets. Then, the pellets were coated sequentially with an inner swelling layer containing low-substituted hydroxypropylcellulose as the swelling agent and an outer rupturable layer of ethylcellulose. Finally, SXSRC were developed by encapsulating five kinds of pellets whose respective coating level of outer layer was 0%, 9%, 15%, 18% and 20% at equivalent ratio in hard gelatin capsules. Under the simulated gastrointestinal pH conditions, the in vitro release test of SXSRC was carried out. The value of similarity factor (f2) of hydroxysafflor yellow A and Panax notoginseng saponins, hydroxysafflor yellow A and ferulic acid, Panax notoginseng saponins and ferulic acid was 90.1, 77.3, 87.0, respectively. The release profiles of these three compositions from SXSRC showed a characteristic of obvious sustained-release and no significant difference between them. The results indicated that using multiparticulate time-controlled explosion technology various components in TCMCR with vastly different physicochemical properties could be released synchronously while sustained-releasing. That complies with the organic whole conception of compound compatibility of TCMCR.
Song
Hong-Tao
HT
Department of Pharmacy, Fuzhou General Hospital of Nanjing Military Region, Fuzhou 350025, China. sohoto@sohu.com
Zhang
Qian
Q
Wang
Hui-Juan
HJ
Guo
Xin-Jin
XJ
Chen
Da-Wei
DW
He
Zhong-Gui
ZG
D002214:Capsules; D031178:Carthamus; D002482:Cellulose / Q000031:analogs & derivatives / Q000737:chemistry; D002599:Chalcone / Q000031:analogs & derivatives; D002626:Chemistry, Pharmaceutical; D003373:Coumaric Acids / Q000032:analysis; D003692:Delayed-Action Preparations; D004339:Drug Compounding; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage* / Q000737:chemistry; D005079:Excipients; D030004:Ligusticum; D053723:Panax notoginseng; D011809:Quinones; D012967:Sodium Dodecyl Sulfate; D012995:Solubility; D012996:Solutions; D013608:Tablets, Enteric-Coated
D002214:Capsules; D003373:Coumaric Acids; D003692:Delayed-Action Preparations; D004365:Drugs, Chinese Herbal; D005079:Excipients; D011809:Quinones; D012996:Solutions; D013608:Tablets, Enteric-Coated; C085278:hydroxysafflor yellow A; D012967:Sodium Dodecyl Sulfate; D002599:Chalcone; C013517:ethyl cellulose; D002482:Cellulose; C008079:hydroxypropylcellulose; C004999:ferulic acid