Drug dosing adjustments in patients with chronic kidney disease.
Chronic kidney disease affects renal drug elimination and other pharmacokinetic processes involved in drug disposition (e.g., absorption, drug distribution, nonrenal clearance [metabolism]). Drug dosing errors are common in patients with renal impairment and can cause adverse effects and poor outcomes. Dosages of drugs cleared renally should be adjusted according to creatinine clearance or glomerular filtration rate and should be calculated using online or electronic calculators. Recommended methods for maintenance dosing adjustments are dose reductions, lengthening the dosing interval, or both. Physicians should be familiar with commonly used medications that require dosage adjustments. Resources are available to assist in dosing decisions for patients with chronic kidney disease.
Munar
Myrna Y
MY
Department of Pharmacy Practice, Oregon State University College of Pharmacy, Portland, Oregon, USA. munarm@ohsu.edu
Singh
Harleen
H
D001692:Biological Transport; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004347:Drug Interactions; D016903:Drug Monitoring / Q000379:methods*; D005919:Glomerular Filtration Rate; D006801:Humans; D007676:Kidney Failure, Chronic / Q000188:drug therapy* / Q000378:metabolism*; D008508:Medication Errors / Q000517:prevention & control; D004364:Pharmaceutical Preparations / Q000008:administration & dosage* / Q000378:metabolism*; D010821:Physicians, Family / Q000592:standards*; D010818:Practice Patterns, Physicians'
D004364:Pharmaceutical Preparations