title: Endpoints for lymphatic filariasis programs.
abstract: In 2000, annual mass administration of diethlycarbamazine and albendazole began in Leogane Commune, Haiti, to interrupt transmission of lymphatic filariasis (LF). After 5 years of treatment, microfilaremia, antigenemia, and mosquito infection rates were significantly reduced, but LF transmission was not interrupted. These finding have implications for other LF elimination programs.
authors.affiliation: Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA.
authors.forename: Caroline A
authors.initials: CA
authors.lastname: Grady
authors.forename: Madsen Beau
authors.initials: MB
authors.lastname: de Rochars
authors.forename: Abdel N
authors.initials: AN
authors.lastname: Direny
authors.forename: Jean Nicolas
authors.initials: JN
authors.lastname: Orelus
authors.forename: Joyanna
authors.initials: J
authors.lastname: Wendt
authors.forename: Jeanne
authors.initials: J
authors.lastname: Radday
authors.forename: Els
authors.initials: E
authors.lastname: Mathieu
authors.forename: Jacquelin M
authors.initials: JM
authors.lastname: Roberts
authors.forename: Thomas G
authors.initials: TG
authors.lastname: Streit
authors.forename: David G
authors.initials: DG
authors.lastname: Addiss
authors.forename: Patrick J
authors.initials: PJ
authors.lastname: Lammie
mesh_terms: D015766:Albendazole / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D000818:Animals; D004049:Diethylcarbamazine / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D004605:Elephantiasis, Filarial / Q000188:drug therapy / Q000453:epidemiology* / Q000469:parasitology / Q000517:prevention & control*; D005369:Filaricides / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D006078:Government Programs / Q000592:standards*; D006205:Haiti / Q000453:epidemiology; D006801:Humans; D008842:Microfilariae / Q000187:drug effects; D015995:Prevalence; D015397:Program Evaluation; D014958:Wuchereria bancrofti / Q000187:drug effects
chemical_list: D005369:Filaricides; D015766:Albendazole; D004049:Diethylcarbamazine