title: Antiviral therapy for hepatitis C virus recurrence after liver transplantation in HIV-infected patients: outcome in the Bonn cohort.
abstract: Recurrent hepatitis C is a major cause of mortality in HIV/hepatitis C virus (HCV)-co-infected patients after orthotopic liver transplantation. We report sustained viral clearance in all four transplanted HIV/HCV-positive patients treated with pegylated interferon/ribavirin. Early therapy after HCV recurrence, tailoring treatment duration to the individual decline in HCV-RNA and the management of side effects are key factors for improved efficacy. At experienced centres interferon treatment is a valuable option for recurrent hepatitis C in HIV-positive patients.
authors.affiliation: Department of Infectious Diseases and Hepatology, Medical University of Lodz, 91-347 Lodz, Poland.
authors.forename: Kamila
authors.initials: K
authors.lastname: Wojcik
authors.forename: Martin
authors.initials: M
authors.lastname: Vogel
authors.forename: Esther
authors.initials: E
authors.lastname: Voigt
authors.forename: Nicola
authors.initials: N
authors.lastname: Speidel
authors.forename: Jörg C
authors.initials: JC
authors.lastname: Kalff
authors.forename: Georg
authors.initials: G
authors.lastname: Goldmann
authors.forename: Johannes
authors.initials: J
authors.lastname: Oldenburg
authors.forename: Tilman
authors.initials: T
authors.lastname: Sauerbruch
authors.forename: Jürgen Kurt
authors.initials: JK
authors.lastname: Rockstroh
authors.forename: Ulrich
authors.initials: U
authors.lastname: Spengler
mesh_terms: D000284:Administration, Oral; D000998:Antiviral Agents / Q000008:administration & dosage*; D015331:Cohort Studies; D004359:Drug Therapy, Combination; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy; D006526:Hepatitis C / Q000150:complications / Q000188:drug therapy*; D019698:Hepatitis C, Chronic / Q000150:complications / Q000601:surgery; D006801:Humans; D007279:Injections, Subcutaneous; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000008:administration & dosage; D016031:Liver Transplantation; D011092:Polyethylene Glycols / Q000008:administration & dosage; D012367:RNA, Viral / Q000032:analysis; D011994:Recombinant Proteins; D012008:Recurrence; D012254:Ribavirin / Q000008:administration & dosage; D016896:Treatment Outcome
chemical_list: D000998:Antiviral Agents; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D012367:RNA, Viral; D011994:Recombinant Proteins; D011092:Polyethylene Glycols; D012254:Ribavirin; C100416:peginterferon alfa-2a