title: Development of a computer-aided diagnosis system for continuous peritoneal dialysis: an availability of the simultaneous numerical optimization technique for kinetic parameters in the peritoneal dialysis model.
abstract: We developed a novel diagnostic system for continuous peritoneal dialysis, which evaluates the peritoneal permeability and hydraulic conductance (peritoneal function) by applying the kinetic model and a clinical test with minimum nursing time. Kinetic parameters for the peritoneal function were determined by the simultaneous numerical optimization techniques (SNOT). Furthermore dialysis outcome and ultrafiltration volume were estimated and predicted by using the kinetic model with a set of optimal kinetic parameters, which were in agreement with measured data (r(2)>0.82). The clinical implementation of the SNOT is very useful to explore the better prescriptions for each patient's clinical condition.
authors.affiliation: Laboratory for Bioinformatics, Graduate School of Systems Life Sciences, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan. hamada@brs.kyushu-u.ac.jp
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Hamada
authors.forename: Shinji
authors.initials: S
authors.lastname: Namoto
authors.forename: Ryo
authors.initials: R
authors.lastname: Yamada
authors.forename: Abdullah
authors.initials: A
authors.lastname: Al Mamun
authors.forename: Akihiro C
authors.initials: AC
authors.lastname: Yamashita
authors.forename: Makoto
authors.initials: M
authors.lastname: Ishizaki
authors.forename: Masahiro
authors.initials: M
authors.lastname: Okamoto
mesh_terms: D003198:Computer Simulation; D003936:Diagnosis, Computer-Assisted; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical; D010530:Peritoneal Dialysis; D015203:Reproducibility of Results