title: Current issues in the classification of psychotic major depression.
abstract: Depression is one of the most common mental disorders worldwide. There are a number of depression subtypes, and there has been much debate about how to most accurately capture and organize the features and subtypes of major depression. We review the current state of categorizing unipolar major depression with psychotic features (psychotic major depression, PMD), including clinical, biological, and treatment aspects of the disorder. We then propose some improvements to the current unipolar major depression categorization system. Finally, we identify important issues in need of further research to help elucidate the subtype of unipolar PMD.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305-5723, USA. jkeller@stanford.edu
authors.forename: Jennifer
authors.initials: J
authors.lastname: Keller
authors.forename: Alan F
authors.initials: AF
authors.lastname: Schatzberg
authors.forename: Mario
authors.initials: M
authors.lastname: Maj
mesh_terms: D014150:Antipsychotic Agents / Q000627:therapeutic use; D001714:Bipolar Disorder / Q000453:epidemiology; D003072:Cognition Disorders / Q000453:epidemiology; D003865:Major Depressive Disorder / Q000145:classification* / Q000503:physiopathology / Q000628:therapy; D018450:Disease Progression; D004565:Electroconvulsive Therapy; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology; D010913:Pituitary-Adrenal System / Q000503:physiopathology; D011618:Psychotic Disorders / Q000145:classification* / Q000453:epidemiology / Q000503:physiopathology / Q000628:therapy; D012720:Severity of Illness Index
chemical_list: D014150:Antipsychotic Agents