title: Serum her-2/neu and survivin levels and their relationship to histological parameters in early-stage breast cancer.
abstract: This study was conducted to investigate the serum levels of her-2/neu and survivin in patients with early-stage breast cancer and their relationship with known histological parameters. Forty-one patients with early-stage breast cancer were investigated. Serum samples were collected from patients on their first admission before adjuvant chemotherapy, and from healthy controls. Serum her-2/neu and survivin levels were determined using an enzyme-linked immunosorbent assay. There was no difference in the levels of serum her-2/neu and survivin between the breast cancer patients and the control group. Serum her-2/neu concentration showed moderate correlations with disease stage and the Ki-67 level, and the serum survivin level showed a moderate correlation with progesterone receptor concentration. Serum levels of her-2/neu and survivin were not significantly related to age and histological parameters in patients with early-stage breast cancer. However, much research continues on the prognostic value of serum her-2/neu and survivin levels, and important new knowledge may ultimately emerge.
authors.affiliation: Department of Internal Medicine, Division of Medical Oncology, Celal Bayar University Faculty of Medicine, Manisa, Turkey. gamzegoksel@hotmail.com
authors.forename: G
authors.initials: G
authors.lastname: Goksel
authors.forename: F
authors.initials: F
authors.lastname: Taneli
authors.forename: R
authors.initials: R
authors.lastname: Uslu
authors.forename: C
authors.initials: C
authors.lastname: Ulman
authors.forename: G
authors.initials: G
authors.lastname: Dinc
authors.forename: T
authors.initials: T
authors.lastname: Coskun
authors.forename: A R
authors.initials: AR
authors.lastname: Kandiloglu
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000097:blood* / Q000473:pathology*; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D051034:Inhibitor of Apoptosis Proteins; D008869:Microtubule-Associated Proteins / Q000097:blood*; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000097:blood*; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000097:blood*; D000077022:Survivin
chemical_list: D051034:Inhibitor of Apoptosis Proteins; D008869:Microtubule-Associated Proteins; D009363:Neoplasm Proteins; D018719:Erb-b2 Receptor Tyrosine Kinases; D000077022:Survivin; C107489:BIRC5 protein, human