title: Chromium picolinate and conjugated linoleic acid do not synergistically influence diet- and exercise-induced changes in body composition and health indexes in overweight women.
abstract: This study assessed the effects of combined chromium picolinate (CP) and conjugated linoleic acid (CLA) supplementation on energy restriction and exercise-induced changes in body composition, glucose metabolism, lipid lipoprotein profile and blood pressure in overweight, premenopausal women. For 12 weeks, 35 women [age 36+/-1 years (mean+/-S.E.M.); BMI 28.0+/-0.5 kg/m2] were counseled to consume a 2092 kJ/day (500 kcal/day) energy deficit diet and performed 30 min of moderate-intensity walking or jogging 5 days/week. The women were randomly assigned to ingest either CP-CLA [400 mug chromium (Cr), 1.8 g CLA in 2.4 g tonalin oil, n=19] or placebo (<0.1 microg Cr, 2.4 g canola oil, n=16). Compared to baseline, urinary Cr excretion increased 22-fold, plasma CLA isomer 18:2 (c9,t11) content increased 79% and plasma CLA isomer 18:2 (t10,c12) became detectable in CP-CLA and were unchanged in Placebo. Over time, body weight decreased 3.5+/-0.5% (CP-CLA -2.6+/-0.5; placebo -2.5+/-0.5 kg) and fat mass decreased 8.9+/-1.3% (CP-CLA -2.7+/-0.5, placebo -2.4+/-0.5 kg), with no differences in responses between groups. Fasting blood hemoglobin A1c, plasma glucose and insulin, a homeostatic assessment of insulin resistance, serum total cholesterol (CHOL), high-density lipoprotein cholesterol (HDL), low-density lipoprotein cholesterol, triacylglycerol (TG), CHOL/HDL ratio, TG/HDL ratio and sitting systolic and diastolic blood pressures were not changed over time or influenced by CP-CLA. The use of a combined CP and CLA supplement for 3 months does not affect diet- and exercise-induced changes in weight and body composition or improve indexes of metabolic and cardiovascular health in young overweight women.
authors.affiliation: Department of Foods and Nutrition, Purdue University, West Lafayette, IN 47907, USA.
authors.forename: Megan L
authors.initials: ML
authors.lastname: Diaz
authors.forename: Bruce A
authors.initials: BA
authors.lastname: Watkins
authors.forename: Yong
authors.initials: Y
authors.lastname: Li
authors.forename: Richard A
authors.initials: RA
authors.lastname: Anderson
authors.forename: Wayne W
authors.initials: WW
authors.lastname: Campbell
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure; D001823:Body Composition; D031204:Caloric Restriction; D004032:Diet; D019587:Dietary Supplements; D004357:Drug Synergism; D015444:Exercise; D005260:Female; D006304:Health Status; D006801:Humans; D044243:Linoleic Acids, Conjugated / Q000008:administration & dosage*; D008075:Lipoproteins, HDL / Q000097:blood; D009765:Obesity / Q000503:physiopathology / Q000628:therapy*; D010101:Oxygen Consumption; D010848:Picolinic Acids / Q000008:administration & dosage*; D010919:Placebos; D014280:Triglycerides / Q000097:blood; D015431:Weight Loss
chemical_list: D001786:Blood Glucose; D044243:Linoleic Acids, Conjugated; D008075:Lipoproteins, HDL; D010848:Picolinic Acids; D010919:Placebos; D014280:Triglycerides; C030614:picolinic acid