Preparation, characterization and evaluation of coenzyme Q10 binary solid dispersions for enhanced solubility and dissolution.
Phase solubility behavior of coenzyme Q10 (CoQ10) at 25 degrees C in various molar solutions of poloxamer 188 (P188) in water was observed and their binary solid dispersions (BSD) at different weight ratios were prepared by a simple, rapid, cost effective, uncomplicated and potentially scalable low temperature melting method. BSDs were characterized by scanning electron microscopy (SEM) and differential scanning calorimetry (DSC), and evaluated for improved solubility at 25 degrees C and 37 degrees C and in-vitro release of CoQ10 at 37 degrees C in distilled water. Solubility of CoQ10 increased with increasing concentrations of P188 in water. Gibbs free energy (deltaG(o)tr) values were all negative indicating the spontaneous nature of CoQ10 solubilization and decreased with increasing concentration of P188 demonstrating that the reaction conditions became more favorable as the concentration of P188 increased. DSC and SEM analysis indicated that the homogeneity of dispersion was not at the molecular level. However, BSDs exhibited a remarkably improved aqueous solubility and dissolution of CoQ10.
Bhandari
Krishna Hari
KH
College of Pharmacy, Yeungnam University, Kyungbuk, South Korea.
Newa
Madhuri
M
Kim
Jung Ae
JA
Yoo
Bong Kyu
BK
Woo
Jong Soo
JS
Lyoo
Won Seok
WS
Lim
Hyun Tae
HT
Choi
Han Gon
HG
Yong
Chul Soon
CS
D002152:Calorimetry, Differential Scanning; D002626:Chemistry, Pharmaceutical; D002851:Chromatography, High Pressure Liquid; D003067:Coenzymes / Q000032:analysis / Q000737:chemistry / Q000648:ultrastructure; D004339:Drug Compounding; D005069:Evaluation Studies as Topic; D015394:Molecular Structure; D020442:Poloxamer / Q000737:chemistry; D011208:Powders; D012995:Solubility; D012997:Solvents / Q000737:chemistry; D013056:Spectrophotometry, Ultraviolet; D013696:Temperature; D013816:Thermodynamics; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000032:analysis / Q000737:chemistry / Q000648:ultrastructure; D014867:Water / Q000737:chemistry
D003067:Coenzymes; D011208:Powders; D012997:Solvents; D014867:Water; D020442:Poloxamer; D014451:Ubiquinone; C024989:coenzyme Q10