Human papilloma virus in skin, mouth and uterine cervix in female renal transplant recipients with or without a history of cutaneous squamous cell carcinoma.
Some human papillomaviruses are thought to be associated with skin cancer. In this pilot study, 21 female renal transplant carriers, 10 with a history of skin squamous cell carcinoma and 11 without, together with 9 age-matched healthy women were investigated for human papillomavirus DNA in sun-exposed (forehead) and less sun-exposed (buttock) skin, mouth and uterine cervix. Paraffin-embedded tumours from 9 of the patients with a history of squamous cell carcinoma were analysed. Healthy skin from both the healthy and the immunosuppressed individuals harboured a wide variety of papillomaviruses. In the healthy individuals, samples from less sun-exposed skin showed a lower prevalence of human papillomavirus DNA than corresponding samples from the immunosuppressed patients (4/9 and 7/9, respectively). Among the immunosuppressed patients, human papillomavirus DNA was found as frequently in buttock samples (17/21) as in forehead samples (17/20). There was no increased prevalence of human papillomavirus in the cervix or mouth samples from the immunosuppressed patients.
Nordin
Peter
P
Department of Dermatology, Läkarhuset, Göteborg, Sweden.
Hansson
Bengt Göran
BG
Hansson
Carita
C
Blohmè
Ingemar
I
Larkö
Olle
O
Andersson
Kristin
K
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001609:Beta-Globulins / Q000235:genetics / Q000302:isolation & purification; D002081:Buttocks; D002294:Carcinoma, Squamous Cell / Q000821:virology*; D016022:Case-Control Studies; D002584:Cervix Uteri / Q000821:virology; D004279:DNA, Viral / Q000302:isolation & purification; D005260:Female; D005546:Forehead; D006801:Humans; D016867:Immunocompromised Host; D016030:Kidney Transplantation; D008875:Middle Aged; D014066:Palatine Tonsil / Q000821:virology; D027383:Papillomaviridae / Q000302:isolation & purification*; D010865:Pilot Projects; D016133:Polymerase Chain Reaction; D012867:Skin / Q000821:virology; D012878:Skin Neoplasms / Q000821:virology*; D014059:Tongue / Q000821:virology
D001609:Beta-Globulins; D004279:DNA, Viral