title: Cytotoxic activity of the selected pyridinium salts against murine leukemia L1210.
abstract: The objective of this work was to evaluate the relationship between chemical reactivity of 3-substituted pyridinium salts and their cytotoxic properties against murine leukemia L1210. Chemical reactivity of pyridinium salts towards NADH oxidation following one-step hydride transfer depends strongly on their redox properties. The investigated reaction may reflect the ability of the salts to deplete NADH level in cells and to affect their metabolic functions. On the other hand, the cytotoxic activity against murine leukemia cells, expressed as ED50 values, varied strongly depending upon the compound used. The investigated salts showed also a diverse antileukemic effect in in vivo experiments as measured by the increase in the survival time of L1210 leukemia-bearing mice. These biological effects were correlated with equilibrium constants found for the reaction of pyridinium salts with NADH.
authors.affiliation: Institute of Applied Radiation Chemistry, Technical University of Łódź, Zeromskiego 116, PL 90-924 Łódź, Poland.
authors.forename: Marzena
authors.initials: M
authors.lastname: Wieczorkowska
authors.forename: Piotr
authors.initials: P
authors.lastname: Szajerski
authors.forename: Radosław
authors.initials: R
authors.lastname: Michalski
authors.forename: Jan
authors.initials: J
authors.lastname: Adamus
authors.forename: Andrzej
authors.initials: A
authors.lastname: Marciniak
authors.forename: Jerzy
authors.initials: J
authors.lastname: Gebicki
authors.forename: Ewa
authors.initials: E
authors.lastname: Ciesielska
authors.forename: Leszek
authors.initials: L
authors.lastname: Szmigiero
authors.forename: Ewa
authors.initials: E
authors.lastname: Lech-Marańda
authors.forename: Anna
authors.initials: A
authors.lastname: Szmigielska-Kapłon
authors.forename: Tadeusz
authors.initials: T
authors.lastname: Robak
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D006863:Hydrogen-Ion Concentration; D007939:Leukemia L1210 / Q000188:drug therapy* / Q000473:pathology; D051379:Mice; D009243:NAD / Q000737:chemistry; D010084:Oxidation-Reduction; D011725:Pyridines / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D011725:Pyridines; D009243:NAD