Nucleophilic aromatic substitution using Et3SiH/cat. t-Bu-P4 as a system for nucleophile activation.
A novel type of deprotonative arylation of nucleophiles was conducted using Et(3)SiH/cat. t-Bu-P4 and the powerful S(N)Ar reactions of aryl fluorides were accomplished using alcohols and malonates as nucleophiles.
Ueno
Masahiro
M
Graduate School of Pharmaceutical Sciences, Tohoku University, Aramaki Aza Aoba 6-3, Sendai, 980-8578, Japan.
Yonemoto
Misato
M
Hashimoto
Masahiro
M
Wheatley
Andrew E H
AE
Naka
Hiroshi
H
Kondo
Yoshinori
Y
D000438:Alcohols / Q000737:chemistry; D002073:Butanes / Q000737:chemistry*; D002384:Catalysis; D006841:Hydrocarbons, Aromatic / Q000737:chemistry*; D006845:Hydrocarbons, Fluorinated / Q000737:chemistry*; D008314:Malonates / Q000737:chemistry; D008956:Models, Chemical; D009943:Organophosphorus Compounds / Q000737:chemistry*; D011522:Protons; D012821:Silanes / Q000737:chemistry*
D000438:Alcohols; D002073:Butanes; D006841:Hydrocarbons, Aromatic; D006845:Hydrocarbons, Fluorinated; D008314:Malonates; D009943:Organophosphorus Compounds; D011522:Protons; D012821:Silanes; C521797:tert-butyl-P4; C512918:triethylsilane