title: Chemotypes in Achillea collina based on sesquiterpene lactone profile.
abstract: The lactone profile of six origins of Achillea collina growing in Bulgaria was studied and significant variability was observed. The reasons for the differences in the lactone composition are discussed. Twenty-five components in total were isolated and identified, while the presence of ten lactones was proved by intensive TLC analysis in comparison with reference compounds. The structures of the components 17, 20, 25-30 were established by spectroscopic methods. The structure of 7, a cyclization product of 6, was also discussed. The anti-inflammatory activity of some extracts, fractions and individual compounds was tested in vitro by determining the inhibitory effects on induced human neutrophils.
authors.affiliation: Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria.
authors.forename: Milka
authors.initials: M
authors.lastname: Todorova
authors.forename: Antoaneta
authors.initials: A
authors.lastname: Trendafilova
authors.forename: Bozhanka
authors.initials: B
authors.lastname: Mikhova
authors.forename: Antonina
authors.initials: A
authors.lastname: Vitkova
authors.forename: Helmut
authors.initials: H
authors.lastname: Duddeck
mesh_terms: D031162:Achillea / Q000737:chemistry* / Q000145:classification; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002478:Cells, Cultured; D006801:Humans; D007783:Lactones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D009504:Neutrophils / Q000187:drug effects; D019906:Nuclear Magnetic Resonance, Biomolecular; D010936:Plant Extracts / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000893:Anti-Inflammatory Agents; D007783:Lactones; D010936:Plant Extracts; D012717:Sesquiterpenes