The toll-like receptor 4 Asp299Gly variant and tuberculosis susceptibility in HIV-infected patients in Tanzania.
Toll-like receptor 4 (TLR4) plays an important role in the pattern recognition of Mycobacterium tuberculosis, and polymorphisms in the TLR4 gene influence the function of the receptor. We therefore investigated in a cohort of HIV-infected Tanzanian patients whether the Asp299Gly TLR4 polymorphism is associated with the development of active tuberculosis. We found a greater risk of developing active tuberculosis as well as a reduction in CD4 T-cell counts in patients with the Asp299Gly TLR4 polymorphism.
Ferwerda
Bart
B
Department of Medicine, Radboud University Nijmegen Medical Center, Nijmegen, the Netherlands.
Kibiki
Gibson S
GS
Netea
Mihai G
MG
Dolmans
Wil M V
WM
van der Ven
Andre J
AJ
D018791:CD4 Lymphocyte Count; D015331:Cohort Studies; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics; D015658:HIV Infections / Q000150:complications / Q000453:epidemiology / Q000235:genetics*; D006801:Humans; D011110:Polymorphism, Genetic / Q000235:genetics*; D013636:Tanzania / Q000453:epidemiology; D051197:Toll-Like Receptor 4 / Q000235:genetics*; D014397:Tuberculosis, Pulmonary / Q000150:complications / Q000453:epidemiology / Q000235:genetics*
C495345:TLR4 protein, human; D051197:Toll-Like Receptor 4