title: Structure elucidation of thermal degradation products of amlodipine.
abstract: Thermal degradation of amlodipine base causes intramolecular reactions affording three cyclic products, referred to as AMLDEG-I, AMLDEG-II, and AMLDEG-III, respectively. AMLDEG-I is a cyclized product formed by intramolecular elimination of ammonia from amlodipine. AMLDEG-II is a positional isomer of AMLDEG-I. AMLDEG-III is also intramolecular cyclisation product. The three degradation products were isolated by column chromatography and characterized by FT-IR and 1H and 13C NMR spectroscopy data. The AMLDEG-III was crystallized and its structure was solved by single crystal X-ray diffraction (SXRD).
authors.affiliation: Analytical Research and Development, Matrix Laboratories Ltd., Jeedimetla, Hyderabad, India-500055, India. sivalakshmi@matrixlabsindia.com
authors.forename: A Siva
authors.initials: AS
authors.lastname: Lakshmi Devi
authors.forename: Y
authors.initials: Y
authors.lastname: Srinivasa Rao
authors.forename: M
authors.initials: M
authors.lastname: Satish
authors.forename: G
authors.initials: G
authors.lastname: Jyothi
authors.forename: K
authors.initials: K
authors.lastname: Babu Rao
authors.forename: T
authors.initials: T
authors.lastname: Omdutt
mesh_terms: D017311:Amlodipine / Q000737:chemistry*; D003500:Cyclization; D006358:Hot Temperature; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D014961:X-Ray Diffraction
chemical_list: D017311:Amlodipine