title: Neolemnane-type sesquiterpenoids from a formosan soft coral Paralemnalia thyrsoides.
abstract: Six new sesquiterpenoids, paralemnolins D-I (1-6), have been isolated from the EtOAc extract of the soft coral Paralemnalia thyrsoides. The structures of these metabolites were determined by extensive spectroscopic analysis and by comparison of their spectral data with those of related metabolites. The absolute stereochemistry of these metabolites was established by application of the Mosher's method on 1 and on the basis of the absolute structures of other related compounds previously isolated from the soft corals of the genera Paralemnalia and Lemnalia. Cytotoxicity of these metabolites toward a limited panel of cancer cell lines also is reported.
authors.affiliation: Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung, Taiwan.
authors.forename: Ho-Cheng
authors.initials: HC
authors.lastname: Huang
authors.forename: Chih-Hua
authors.initials: CH
authors.lastname: Chao
authors.forename: Jui-Hsin
authors.initials: JH
authors.lastname: Su
authors.forename: Chi-Hsin
authors.initials: CH
authors.lastname: Hsu
authors.forename: Shin-Pin
authors.initials: SP
authors.lastname: Chen
authors.forename: Yao-Haur
authors.initials: YH
authors.lastname: Kuo
authors.forename: Jyh-Horng
authors.initials: JH
authors.lastname: Sheu
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification*; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D012717:Sesquiterpenes