title: A Possible treatment strategy and clinical factors to estimate the treatment response in Bebesia gibsoni infection.
abstract: The effectiveness of combination therapy using clindamycin, metronidazole and doxycycline against canine babesiosis, and the usefulness of platelet count and the plasma C-reactive protein (CRP) concentration as an estimation factor for treatment, were evaluated in four dogs experimentally infected with Babesia gibsoni. The combination therapy successfully eliminated B. gibsoni in peripheral blood in 3 of 4 dogs, however the remaining dog showed obvious uncontrolled relapse after a temporary recovery. In addition, it was shown that CRP levels decreased in an inverse relationship to the recovery of packed cell volume and therefore CRP levels could be used as an optional clinical marker to estimate the response to treatment.
authors.affiliation: Laboratory of Veterinary Internal Medicine, Faculty of Agriculture, Kagoshivma University, Korimoto, Kagoshima, Japan.
authors.forename: Koretoki
authors.initials: K
authors.lastname: Suzuki
authors.forename: Haruna
authors.initials: H
authors.lastname: Wakabayashi
authors.forename: Masashi
authors.initials: M
authors.lastname: Takahashi
authors.forename: Kenjiro
authors.initials: K
authors.lastname: Fukushima
authors.forename: Akira
authors.initials: A
authors.lastname: Yabuki
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Endo
mesh_terms: D000818:Animals; D001403:Babesia; D001404:Babesiosis / Q000188:drug therapy / Q000662:veterinary*; D002097:C-Reactive Protein / Q000032:analysis*; D002981:Clindamycin / Q000627:therapeutic use*; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D004318:Doxycycline / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D008795:Metronidazole / Q000627:therapeutic use*; D010976:Platelet Count / Q000662:veterinary
chemical_list: D008795:Metronidazole; D002981:Clindamycin; D002097:C-Reactive Protein; D004318:Doxycycline