title: Gastric feed intolerance is not increased in critically ill patients with type II diabetes mellitus.
abstract: OBJECTIVE
  To examine the occurrence of feed intolerance in critically ill patients with previously diagnosed type II diabetes mellitus (DM) who received prolonged gastric feeding.
  
  
  METHODS
  Retrospective study in a level 3 mixed ICU.
  
  
  METHODS
  All mechanically ventilated, enterally fed patients (n = 649), with (n = 118) and without type II DM (n = 531) admitted between January 2003 and July 2005.
  
  
  METHODS
  Patients with at least 72 h of gastric feeding were identified by review of case notes and ICU charts. The proportion that developed feed intolerance was determined. All patient received insulin therapy.
  
  
  RESULTS
  The proportion of patients requiring gastric feeding for at least 72 h was similar between patients with and without DM (42%, 50/118, vs. 42%, 222/531). Data from patients with DM were also compared with a group of 50 patients matched for age, sex and APACHE II score, selected from the total non-diabetic group. The occurrence of feed intolerance (DM 52% vs. matched non-DM 50% vs. unselected non-diabetic 58%) and the time taken to develop feed intolerance (DM 62.6 +/- 43.8 h vs. matched non-DM 45.3 +/- 54.6 vs. unselected non-diabetic 50.6 +/- 59.5) were similar amongst the three groups. Feed intolerance was associated with a greater use of morphine/midazolam and vasopressor support, a lower feeding rate and a longer ICU length of stay.
  
  
  CONCLUSIONS
  In critically ill patients who require prolonged enteral nutrition, a prior history of DM type II does not appear to be a further risk factor for feed intolerance.
authors.affiliation: Department of Gastroenterology, Royal Adelaide Hospital, North Terrace, 5000, Adelaide, SA, Australia. Qnguyen@mail.rah.sa.gov.au
authors.forename: S W
authors.initials: SW
authors.lastname: Lam
authors.forename: N Q
authors.initials: NQ
authors.lastname: Nguyen
authors.forename: K
authors.initials: K
authors.lastname: Ching
authors.forename: M
authors.initials: M
authors.lastname: Chapman
authors.forename: R J
authors.initials: RJ
authors.lastname: Fraser
authors.forename: R H
authors.initials: RH
authors.lastname: Holloway
mesh_terms: D016638:Critical Illness; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology*; D004750:Enteral Nutrition / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged