[Effectiveness of nasal vs oral estrogens in the climacteric syndrome].
BACKGROUND
Hormone replacement therapy reestablishes the diminished hormonal level and reduces mild, moderate and severe effects of climacteric. Its treatment includes estrogens, progestagens and a mixture of both.


OBJECTIVE
To evaluate the efficacy of intranasal and oral estrogens in the climacteric syndrome.


METHODS
60 patients were evaluated with climacteric syndrome; 30 received intranasal estrogens (group A) and 30 received oral estrogens (group B). Age range, 34-64 years. The symptoms were classified as vasomotor, collagen related symptoms and tropic changes. The patients were evaluated four times a week, and the symptoms were measured as mild, moderate and severe according with the Guía de evaluación de riesgo en la paciente climatérica.


RESULTS
Group A (intranasal estrogens) showed faster clinical response in the first two weeks (63%), compared with group B (30%). No side effects were found in both groups.


CONCLUSIONS
Climacteric syndrome can be treated better and faster with intranasal estrogens than with oral estrogens, and without side effects.
Romano Lagunas
Gabriela Liliana
GL
Hospital Regional General Ignacio Zaragoza, ISSSTE, México, DF. galirolaa@hotmail.com
Miranda Murillo
Juan
J
Vázquez López
Alfonso A
AA
Coronel Cruz
Fausto
F
Guerra Ulloa
Patricio
P
D000281:Administration, Intranasal; D000284:Administration, Oral; D000328:Adult; D000336:Aerosols; D004967:Estrogens / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008593:Menopause / Q000187:drug effects* / Q000502:physiology*; D008875:Middle Aged
D000336:Aerosols; D004967:Estrogens