Influence of androgen suppression therapy for prostate cancer on the frequency and timing of fatal myocardial infarctions.
OBJECTIVE
We evaluated whether the timing of fatal myocardial infarction (MI) was influenced by the administration of androgen suppression therapy (AST).


METHODS
The study cohort comprised 1,372 men who were enrolled onto three randomized trials between February 1995 and June 2001. In the three trials, the men were randomly assigned to receive radiation therapy with 0 versus 3 versus 6, 3 versus 8, or 0 versus 6 months of AST. Fine and Gray's regression was used to determine the clinical factors associated with the time to fatal MI, and estimates of time to fatal MI were calculated using a cumulative incidence method. When comparing the cumulative incidence estimates using Gray's k-sample P values, increased weight was ascribed to the earlier data because recovery of testosterone is expected for most men within 2 years after short-course AST.


RESULTS
Men age 65 years or older who received 6 months of AST experienced shorter times to fatal MIs compared with men in this age group who did not receive AST (P = .017) and men younger than 65 years (P = .016). No significant difference (P = .97) was observed in the time to fatal MIs in men age 65 years or older who received 6 to 8 months of AST compared with 3 months of AST.


CONCLUSIONS
The use of AST is associated with earlier onset of fatal MIs in men age 65 years or older who are treated for 6 months compared with men who are not treated with AST.
D'Amico
Anthony V
AV
Departments of Radiation Oncology and Medicine, Cardiovascular Division, Brigham and Women's Hospital and Lank Center for Genitourinary Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA. adamico@lroc.harvard.edu
Denham
James W
JW
Crook
Juanita
J
Chen
Ming-Hui
MH
Goldhaber
Samuel Z
SZ
Lamb
David S
DS
Joseph
David
D
Tai
Keen-Hun
KH
Malone
Shawn
S
Ludgate
Charles
C
Steigler
Allison
A
Kantoff
Philip W
PW
D000367:Age Factors; D000368:Aged; D000726:Androgen Antagonists / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000139:chemically induced* / Q000401:mortality*; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy; D016032:Randomized Controlled Trials as Topic; D012307:Risk Factors
D000726:Androgen Antagonists