Lymphadenopathy, elevated liver function tests and weight loss in a 68-year-old man.
A 68-year-old man presented to the hospital with fevers, weight loss, lymphadenopathy and abnormal liver-associated enzymes. After a thorough workup, a liver biopsy demonstrated histiocytes with phagocytosis of the lymphocytes and a positive immunostain for S-100. The diagnosis of Rosai-Dorfman disease was made. This case report will discuss the patient's presentation as well as the diagnosis and treatment of this rare, non-malignant disorder, which only rarely affects the liver.
Krok
Karen L
KL
Division of Gastroenterology and Hepatology, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Torbenson
Micheal S
MS
Schulick
Richard D
RD
Thuluvath
Paul J
PJ
D000368:Aged; D001707:Biopsy, Needle; D015618:Histiocytosis, Sinus / Q000150:complications / Q000175:diagnosis* / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008111:Liver Function Tests; D008206:Lymphatic Diseases / Q000000981:diagnostic imaging / Q000209:etiology*; D008297:Male; D011859:Radiography; D015431:Weight Loss