title: A comparative analysis of tuberculous, brucellar and pyogenic spontaneous spondylodiscitis patients.
abstract: OBJECTIVE
  This study aimed to compare clinical, laboratory, and radiological features of spontaneous spondylodiscitis secondary to tuberculosis and brucellosis, both of which are endemic in Turkey, and spondylodiscitis due to other bacterial causes (pyogenic spondylodiscitis) and to provide guidance for clinicians in determining causative agents of spondylodiscitis.
  
  
  METHODS
  This prospective study involved 75 patients diagnosed as spondylodiscitis. All the patients were divided into three groups: tuberculous spondylodiscitis (Group TS), brucellar spondylodiscitis (Group BS), and pyogenic spondylodiscitis (Group PS).
  
  
  RESULTS
  Forty patients (53.3%) were male and 35 (46.7%), female. The mean age of the patients was 57.8+/-14.8 years (17-82 years). Group TS included 13 patients (17.3%), Group BS 32 patients (42.7%), and Group PS 30 patients (40%). A significantly higher rate of microorganisms was isolated and a significantly higher rate of high fever was determined in Group BS. Group TS had a significantly higher rate of accompanying chronic renal failure, constitutional symptoms, psoas abscess, history of tuberculosis, high sedimentation rate, involvement of posterior elements, and/or surgical treatment.
  
  
  CONCLUSIONS
  The presence of back pain, fever, elevated inflammatory markers and a documented history of tuberculosis in association with radiological involvement of the posterior spinous elements is pathognomonic of tuberculous spinal infection, even in the absence of positive culture.
authors.affiliation: Department of Infectious Diseases and Clinical Microbiology, Başkent University School of Medicine, 16 sok. No: 11 Bahçelievler, Ankara, Turkey. tubaturunc@yahoo.com
authors.forename: Tuba
authors.initials: T
authors.lastname: Turunc
authors.forename: Yusuf Ziya
authors.initials: YZ
authors.lastname: Demiroglu
authors.forename: Hikmet
authors.initials: H
authors.lastname: Uncu
authors.forename: Sule
authors.initials: S
authors.lastname: Colakoglu
authors.forename: Hande
authors.initials: H
authors.lastname: Arslan
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000995:Antitubercular Agents / Q000627:therapeutic use; D002002:Brucella / Q000302:isolation & purification / Q000472:pathogenicity*; D015299:Discitis / Q000188:drug therapy / Q000382:microbiology* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000472:pathogenicity*; D011183:Postoperative Complications; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D000995:Antitubercular Agents