title: Improved antimicrobial peptides based on acyl-lysine oligomers.
abstract: We describe peptidomimetic oligomers that show rapid, nonhemolytic, broad-spectrum bactericidal properties in mice and do not induce the emergence of resistance. The oligomers contain acyl chains, which prevent the formation of stable secondary structure. This design appears advantageous over conventional antimicrobial peptides with respect to in vivo efficacy and safety, and may provide a convenient platform for the development of peptide antibiotics.
authors.affiliation: Department of Biotechnology & Food Engineering, Technion-Israel Institute of Technology, Haifa 32000, Israel.
authors.forename: Inna S
authors.initials: IS
authors.lastname: Radzishevsky
authors.forename: Shahar
authors.initials: S
authors.lastname: Rotem
authors.forename: Dmitry
authors.initials: D
authors.lastname: Bourdetsky
authors.forename: Shiri
authors.initials: S
authors.lastname: Navon-Venezia
authors.forename: Yehuda
authors.initials: Y
authors.lastname: Carmeli
authors.forename: Amram
authors.initials: A
authors.lastname: Mor
mesh_terms: D000818:Animals; D023181:Antimicrobial Cationic Peptides / Q000008:administration & dosage* / Q000737:chemistry*; D019281:Dimerization; D015195:Drug Design; D007274:Injections, Intraperitoneal; D008239:Lysine / Q000737:chemistry*; D051379:Mice; D010538:Peritonitis / Q000175:diagnosis / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D023181:Antimicrobial Cationic Peptides; D008239:Lysine