title: A polymorphism of microRNA 27a genome region is associated with the development of gastric mucosal atrophy in Japanese male subjects.
abstract: Noncoding microRNAs regulate the expression of various mRNAs. We attempted to clarify the relationship between miR-27a genome polymorphism and chronic gastritis. The study was performed in 179 patients with no evidence of gastric malignancy. The severity of histologic chronic gastritis was classified according to the updated Sydney system. The frequency of miR-27a G allele was 34.6%. Although the frequencies of miR-27a G allele were increased in subjects with peptic ulcer or severe mucosal atrophy, no significant differences were seen. The miR-27a polymorphism showed an interaction with gender in relation to gastric mucosal atrophy (P=.090). In only male subjects, the miR-27a polymorphism was associated with the gastric mucosal atrophy (P=.039) and both atrophy and metaplasia scores in G/G group were significantly higher than those in the other groups. The miR-27a genome region polymorphism may be an important definitive factor to develop the gastric mucosal atrophy in Japanese male subjects.
authors.affiliation: Department of Gastroenterology, Fujita Health University, School of Medicine, 1-98, Dengakugakubo, Toyoake, Japan. tarisawa@fujita-hu.ac.jp
authors.forename: Tomiyasu
authors.initials: T
authors.lastname: Arisawa
authors.forename: Tomomitsu
authors.initials: T
authors.lastname: Tahara
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Shibata
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Nagasaka
authors.forename: Masakatsu
authors.initials: M
authors.lastname: Nakamura
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Kamiya
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Fujita
authors.forename: Shin
authors.initials: S
authors.lastname: Hasegawa
authors.forename: Tamaki
authors.initials: T
authors.lastname: Takagi
authors.forename: Fang-Yu
authors.initials: FY
authors.lastname: Wang
authors.forename: Ichiro
authors.initials: I
authors.lastname: Hirata
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nakano
mesh_terms: D044466:Asian People; D005260:Female; D005757:Gastritis, Atrophic / Q000235:genetics*; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D011110:Polymorphism, Genetic; D012189:Retrospective Studies; D012720:Severity of Illness Index; D012737:Sex Factors
chemical_list: D035683:MicroRNAs