title: Mast cell infiltration is a favourable prognostic factor in diffuse large B-cell lymphoma.
abstract: Previous studies indicate that the inflammatory response in diffuse large B-cell lymphomas (DLBCL) is important for the clinical outcome. Mast cells are key regulators in this response; we investigated whether the number of tryptase-positive mast cells is correlated with clinical outcome. Patients with many mast cells had a significantly better event-free survival (EFS) compared to those with few mast cells (P < 0.03 in both germinal centre (GC) and non-GC DLBCL. This supports the idea that the infiltration of mast cells is a reflection of the host inflammatory response and is related to a favourable outcome.
authors.affiliation: Department of Oncology, Radiology and Clincial Immunology, Uppsala University, Uppsala, Sweden. gustaf.hedstrom@onkologi.uu.se
authors.forename: Gustaf
authors.initials: G
authors.lastname: Hedström
authors.forename: Mattias
authors.initials: M
authors.lastname: Berglund
authors.forename: Daniel
authors.initials: D
authors.lastname: Molin
authors.forename: Marie
authors.initials: M
authors.lastname: Fischer
authors.forename: Gunnar
authors.initials: G
authors.lastname: Nilsson
authors.forename: Ulf
authors.initials: U
authors.lastname: Thunberg
authors.forename: Majlis
authors.initials: M
authors.lastname: Book
authors.forename: Christer
authors.initials: C
authors.lastname: Sundström
authors.forename: Richard
authors.initials: R
authors.lastname: Rosenquist
authors.forename: Göran
authors.initials: G
authors.lastname: Roos
authors.forename: Martin
authors.initials: M
authors.lastname: Erlanson
authors.forename: Rose-Marie
authors.initials: RM
authors.lastname: Amini
authors.forename: Gunilla
authors.initials: G
authors.lastname: Enblad
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000032:analysis; D002465:Cell Movement; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D016403:Lymphoma, Large B-Cell, Diffuse / Q000276:immunology*; D008297:Male; D008407:Mast Cells / Q000201:enzymology / Q000473:pathology*; D008875:Middle Aged; D011379:Prognosis; D016016:Proportional Hazards Models; D018709:Statistics, Nonparametric; D016019:Survival Analysis; D053802:Tryptases / Q000032:analysis
chemical_list: D015415:Biomarkers; D053802:Tryptases