title: HPV type-specific risks of high-grade CIN during 4 years of follow-up: a population-based prospective study.
abstract: We followed a population-based cohort of 5696 women, 32-38 years of age, by registry linkage with cytology and pathology registries during a mean follow-up time of 4.1 years to assess the importance for CIN2+ development of type-specific HPV DNA positivity at baseline. HPV 16, 31 and 33 conveyed the highest risks and were responsible for 33.1, 18.3 and 7.7% of CIN2+ cases, respectively. Women infected with HPV 18, 35, 39, 45, 51, 52, 56, 58, 59 and 66 had significantly lower risks of CIN2+ than women infected with HPV 16. After adjustment for infection with other HPV types, HPV types 35, 45, 59 and 66 had no detectable association with CIN2+. In summary, the different HPV types found in cervical cancer show distinctly different CIN2+ risks, with high risks being restricted to HPV 16 and its close relatives HPV 31 and HPV 33.
authors.affiliation: Department of Medical Microbiology, MAS University Hospital, Lund University, S-20502 Malmö, Sweden.
authors.forename: P
authors.initials: P
authors.lastname: Naucler
authors.forename: W
authors.initials: W
authors.lastname: Ryd
authors.forename: S
authors.initials: S
authors.lastname: Törnberg
authors.forename: A
authors.initials: A
authors.lastname: Strand
authors.forename: G
authors.initials: G
authors.lastname: Wadell
authors.forename: B G
authors.initials: BG
authors.lastname: Hansson
authors.forename: E
authors.initials: E
authors.lastname: Rylander
authors.forename: J
authors.initials: J
authors.lastname: Dillner
mesh_terms: D000328:Adult; D052685:Alphapapillomavirus / Q000145:classification / Q000302:isolation & purification*; D015331:Cohort Studies; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D005500:Follow-Up Studies; D052162:Human papillomavirus 16 / Q000302:isolation & purification; D006801:Humans; D015994:Incidence; D011159:Population Surveillance; D011446:Prospective Studies; D012307:Risk Factors; D002578:Uterine Cervical Dysplasia / Q000821:virology*
chemical_list: D004279:DNA, Viral