Quantification by magnetic resonance imaging and liver consequences of post-transfusional iron overload alone in long term survivors after allogeneic hematopoietic stem cell transplantation (HSCT).
We quantified and studied the impact of post transfusional iron overload alone in post allogeneic HSCT. Median number of RBCs was 18. Ferritin was 532 mg/L. Liver iron content (LIC) was 117 mmoles/gdw. Correlation RBCs and ferritin was (r=0.81); RBCs and LIC was (r=0.84). The high ferritin group differed from normal ferritin group in terms of RBCs transfused (p<10(-3)), ALT (p<0.009). But occurrence of liver dysfunction was not significant. Magnitude of iron overload correlates closely to the number of RBCs and is quantified by MRI. Impact on liver dysfunction is moderate in absence of co-morbidity.
Rose
Christian
C
Service d'Hématologie, Groupe Hospitalier de l'Institut CatholiqueService of Hemotherapy and Hemostasis, Hospital Clínic, Barcelona, Spain. Rose.Christian@ghicl.net
Ernst
Olivier
O
Hecquet
Bernard
B
Maboudou
Patrice
P
Renom
Pascale
P
Noel
Marie Pierre
MP
Yakoub-Agha
Ibrahim
I
Bauters
Francis
F
Jouet
Jean Pierre
JP
D000293:Adolescent; D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D019190:Iron Overload / Q000175:diagnosis* / Q000209:etiology; D008107:Liver Diseases / Q000175:diagnosis / Q000209:etiology; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D017741:Survivors; D014184:Transplantation, Homologous