ICAM-1 expression determines malignant potential of cancer.
Solid tumor cells bind to ICAM-1 on endothelial surfaces via MUC-1. Tumor binding to ICAM-1 auto-upregulates tumor ICAM-1 at the leading edge of the tumor and promotes release of chemoattractants for circulating macrophages, and circulating macrophages bind to tumor-expressed ICAM-1, invoking propagation of further chemokines and cytokines that recruit neutrophils. Tight adherence between cell surface ligands on neutrophils and tumor-expressed ICAM-1 activates neutrophils to degranulate, releasing elastases, which break down endovascular and endolymphatic barriers permitting transendothelial tumor cell migration. Consequently, tumor cell ICAM-1 expression dictates metastatic potential and metastatic potential determines cancer lethality.
Roland
Christina L
CL
Department of Surgery, University of Texas Southwestern Medical Center, Dallas, Tex., USA.
Harken
Alden H
AH
Sarr
Michael G
MG
Barnett
Carlton C
CC
D016207:Cytokines / Q000096:biosynthesis; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism*; D008264:Macrophages / Q000378:metabolism / Q000473:pathology; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000378:metabolism* / Q000401:mortality* / Q000473:pathology
D016207:Cytokines; D018799:Intercellular Adhesion Molecule-1