Review on uraemic solutes II--variability in reported concentrations: causes and consequences.
The aim of this manuscript is to initiate a constructive discussion about deviations in measured concentrations of uraemic solutes; these deviations, if not perceived or handled appropriately, may lead to incorrect interpretations of the pathophysiological role of uraemic solutes and/or to erroneous therapeutic decisions. To come to an objective approach towards this problem, variability analysis of reported concentrations may be of help. Striking outliers should either be discarded or considered together with other values which are more consistent with the majority of reported data.
Vanholder
Raymond
R
Meert
Nathalie
N
Schepers
Eva
E
Glorieux
Griet
G
Argiles
Angel
A
Brunet
Philippe
P
Cohen
Gerald
G
Drüeke
Tilman
T
Mischak
Harald
H
Spasovski
Goce
G
Massy
Ziad
Z
Jankowski
Joachim
J
D006801:Humans; D007676:Kidney Failure, Chronic / Q000503:physiopathology*; D014118:Toxins, Biological / Q000378:metabolism*; D014511:Uremia / Q000209:etiology / Q000503:physiopathology*
D014118:Toxins, Biological