Anti-inflammatory benzenoids from Antrodia camphorata.
Four new compounds, including three new benzenoids, antrocamphin A (1), antrocamphin B (2), and 2,3,4,5-tetramethoxybenzoyl chloride (3), and a new 1,3-dioxolan-2-one derivative, antrodioxolanone (4), together with 13 known compounds have been isolated from the fruiting body of Antrodia camphorata. The structures of these new compounds were determined through spectral analyses including extensive 2D-NMR data. Among the isolates, antrocamphin A (1), antcin A (10), and antcin B (11) exhibited potent inhibition against fMLP-induced superoxide production with IC50 values less than 10 microM.
Chen
Jih-Jung
JJ
Graduate Institute of Pharmaceutical Technology, Tajen University, Pingtung 907, Taiwan, Republic of China. jjchen@mail.tajen.edu.tw
Lin
Wen-Jiou
WJ
Liao
Chang-Hui
CH
Shieh
Po-Chuen
PC
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001555:Benzene Derivatives / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D048690:Fruiting Bodies, Fungal / Q000737:chemistry*; D006801:Humans; D015394:Molecular Structure; D009504:Neutrophils / Q000187:drug effects*; D019906:Nuclear Magnetic Resonance, Biomolecular; D020072:Polyporales / Q000737:chemistry*; D013624:Taiwan
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001555:Benzene Derivatives