title: "Machiavellianism" and frontal dysfunction: evidence from Parkinson's disease.
abstract: BACKGROUND
  A number of reports have identified significant personality differences in patients with Parkinson's disease (PD) when compared with age-matched controls. We hypothesised that these differences may be related to impairment in prefrontal inhibitory functions resulting in the expression of new "Machiavellian" personality traits.
  
  
  METHODS
  Thirty-five patients with PD and 17 age-matched controls were assessed with a set of neuropsychologic, personality and mood tests as well as the Mach IV scale, which measures a set of "Machiavellian" personality characteristics.
  
  
  RESULTS
  PD patients with elevated Machiavellian traits ("high Machs") were selectively impaired on tests of prefrontal function relative to "low Mach" patients. In addition, while high Machs did not differ from low Machs in terms of age, educational level, Hoehn-Yahr stage, mood function, or Mini Mental State Exam score, they indicated greater willingness to affiliate with a fictional Machiavellian character and scored significantly lower on the "cooperativeness" and "self-directedness" subscales of the Cloninger Temperament and Character Inventory.
  
  
  CONCLUSIONS
  We suggest that (1) PD patients with frontal impairment are vulnerable to dramatic personality change, and (2) the frontal lobes are required for maintenance of prosocial personality traits.
authors.affiliation: Department of Neurology, Boston University School of Medicine, and VA Boston Healthcare System, Boston, MA, USA. mcnamar@bu.edu
authors.forename: Patrick
authors.initials: P
authors.lastname: McNamara
authors.forename: Raymon
authors.initials: R
authors.lastname: Durso
authors.forename: Erica
authors.initials: E
authors.lastname: Harris
mesh_terms: D000342:Affective Symptoms / Q000175:diagnosis / Q000503:physiopathology / Q000523:psychology; D000368:Aged; D005260:Female; D005625:Frontal Lobe / Q000503:physiopathology*; D006801:Humans; D007266:Inhibition, Psychological; D008257:Machiavellianism; D008297:Male; D008609:Mental Status Schedule; D008875:Middle Aged; D009483:Neuropsychological Tests / Q000706:statistics & numerical data*; D010300:Parkinson Disease / Q000503:physiopathology* / Q000523:psychology; D010555:Personality Inventory / Q000706:statistics & numerical data*; D017397:Prefrontal Cortex / Q000503:physiopathology*; D011594:Psychometrics / Q000706:statistics & numerical data; D012016:Reference Values; D013694:Temperament; D014728:Veterans / Q000523:psychology*