Building ribosomes: even more expensive than expected?
Recent quantitative analyses of ribosomal protein trafficking in HeLa cells have revealed a prominent and unexpected role for the proteasome in regulating the availability of ribosomal proteins for subunit assembly.
Granneman
Sander
S
Wellcome Trust Centre for Cell Biology, University of Edinburgh, Mayfield Road, Kings Buildings, Michael Swann Building, Edinburgh EH9 3JR, Scotland, UK.
Tollervey
David
D
D002466:Cell Nucleolus / Q000378:metabolism; D036681:Fluorescence Recovery After Photobleaching; D049452:Green Fluorescent Proteins / Q000032:analysis; D006367:HeLa Cells; D006801:Humans; D007553:Isotope Labeling; D046988:Proteasome Endopeptidase Complex / Q000502:physiology; D021381:Protein Transport; D040901:Proteomics; D011993:Recombinant Fusion Proteins / Q000032:analysis; D012269:Ribosomal Proteins / Q000378:metabolism*; D012270:Ribosomes / Q000378:metabolism*
D011993:Recombinant Fusion Proteins; D012269:Ribosomal Proteins; D049452:Green Fluorescent Proteins; D046988:Proteasome Endopeptidase Complex