[Expression of aquaporins 1, 3, 8, 9 mRNA in human fetal membranes].
OBJECTIVE
To investigate the expression of aquaporin (AQP)-1, 3, 8, 9 in human fetal membrane and their role in the human amniotic fluid circulation.


METHODS
RT-PCR was employed for detection of the expressions of AQP-1, 3, 8, 9 mRNA in human amnion and chorion from 20 women with normal term pregnancy.


RESULTS
AQP-1, 3, 8, 9 mRNA expression was detected in both human amnion and chorion, and no significant difference was found in their expression levels or between the amnion and chorion (P>0.05).


CONCLUSIONS
AQP-1, 3, 8, 9 can be associated with intramembranous transport and volume regulation of amniotic fluid.
Zhang
Rui
R
Department of Obstetrics and Gynecology, Second Affiliated Hospital of Sun Yat-sen University, Guangzhou 510120, China.
Yang
Dong-Zi
DZ
Liu
Ying-Lin
YL
Gou
Chen-Yu
CY
Zhang
Jian-Ping
JP
Wang
Yun-Hui
YH
D000328:Adult; D000650:Amnion / Q000196:embryology / Q000378:metabolism; D051398:Aquaporin 1 / Q000235:genetics; D051400:Aquaporin 3 / Q000235:genetics; D020346:Aquaporins / Q000235:genetics*; D002823:Chorion / Q000196:embryology / Q000378:metabolism; D004587:Electrophoresis, Agar Gel; D005321:Extraembryonic Membranes / Q000196:embryology / Q000378:metabolism*; D005260:Female; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D011247:Pregnancy; D020133:Reverse Transcriptase Polymerase Chain Reaction
C109669:AQP9 protein, human; D020346:Aquaporins; C108330:aquaporin 8; D051398:Aquaporin 1; D051400:Aquaporin 3