DNA microarray analysis of transcriptional responses of yeast cells to expression of core protein of hepatitis C virus.
We monitored transcriptional changes in yeast cells in response to induced expression of the core protein of hepatitis C virus (HCV) using a DNA microarray. Expression of 16 genes involved in the unfolded-protein response was enhanced by inducing expression of the core protein in yeast cells.
Kubota
Naoko
N
Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University, Aza-Aoba, Aramaki, Sendai, Japan.
Naganuma
Akira
A
Kuge
Shusuke
S
D015967:Gene Expression Regulation, Viral; D016174:Hepacivirus / Q000235:genetics / Q000378:metabolism*; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods*; D012441:Saccharomyces cerevisiae / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism*; D014158:Transcription, Genetic; D014758:Viral Core Proteins / Q000737:chemistry / Q000378:metabolism*
D029701:Saccharomyces cerevisiae Proteins; D014758:Viral Core Proteins; C069130:nucleocapsid protein, Hepatitis C virus