title: [Protective effects of lidocaine against lung injury after hemorrhagic shock in rabbits].
abstract: OBJECTIVE
  To study the protective effect of lidocaine against lung injury after hemorrhagic shock in rabbits.
  
  
  METHODS
  Eighteen healthy rabbits were randomly divided into 3 groups (n=6), namely lidocaine group (group L), hemorrhagic shock group (group H) and control group (group C). Hemorrhagic shock model was established in rabbits in groups L and H, and the venous blood samples were collected for measurement of plasma malondialdehyde (MDA) and superoxidedismutase (SOD) before phlebotomy (T0), 2 h after hemorrhagic shock (T1) and 2 h after resuscitation (T2). Blood samples were also taken for measurement of MDA and SOD at the same time points in group C. The wet to dry weight ratio of the lung (W/D) was measured at T2.
  
  
  RESULTS
  MDA level was significantly lower while SOD level significantly higher in group L than in group H (P<0.05). The W/D ratio in group L was reduced significantly as compared with that in group H (P<0.05).
  
  
  CONCLUSIONS
  Lidocaine can remarkably alleviate lung injury after hemorrhagic shock by inhibiting MDA production and increasing SOD content.
authors.affiliation: Department of Anesthesiology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. rly25741@ yahoo.com.cn
authors.forename: Luo-yang
authors.initials: LY
authors.lastname: Ruan
authors.forename: Chun-shui
authors.initials: CS
authors.lastname: Lin
authors.forename: Ying-ying
authors.initials: YY
authors.lastname: Liu
authors.forename: Miao-ning
authors.initials: MN
authors.lastname: Gu
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D008012:Lidocaine / Q000494:pharmacology*; D008168:Lung / Q000187:drug effects / Q000378:metabolism; D055370:Lung Injury / Q000517:prevention & control*; D008315:Malondialdehyde / Q000097:blood; D011817:Rabbits; D012771:Shock, Hemorrhagic / Q000188:drug therapy*; D013482:Superoxide Dismutase / Q000097:blood
chemical_list: D008315:Malondialdehyde; D008012:Lidocaine; D013482:Superoxide Dismutase