The influence of the age in the risk of the prothrombin G20210A mutation for spontaneous venous thrombosis.
OBJECTIVE
Factor V Leiden mutation (FVL), and the prothrombin G20210A mutation (PT G20210A) are polymorphisms with a weak risk factor for venous thromboembolic disease. The probability of spontaneous venous thrombosis in carriers of thrombophilic mutations (FVL and PT G20210A) was analyzed.


METHODS
We studied 735 individuals (407 were healthy controls and 328 patients with venous thrombosis) with respect to FVL and PT G20210A, determined by polimerase chain reaction in liquid phase, real time. chi2 test and logistic regression analysis were used to evaluate the results. The dates were analyzed with the statistical program SPSS v. 14.0.


RESULTS
The carrier patients of PT G20210A mutation whose age was over 40 years had a risk factor for spontaneous venous thrombosis which was 9.28 (odds ratio [OR]) (95% confidence interval [CI], 3.01-28.60; p < 0.0005) times greater than carriers of the PT G20210A mutation who were 40 year-old or younger. In our patients, being male meant a weak risk factor for venous spontaneous thrombosis (p = 0.021; OR = 1.64; 95% CI, 1.08-2.51) .


CONCLUSIONS
Our results demonstrate a potentiation of the thrombotic risk by an increase of age in the carriers of the PT G20210A mutation.
Gutiérrez Tous
María Reyes
MR
Department of Hematology, The Valme University Hospital, Seville, Spain. mariar.gutierrez.sspa@juntadeandalucia.es
Couto Caro
Carmen
C
García-Donas Gabaldón
Gloria
G
Viloria Peñas
María del Mar
Mdel M
Simón Pilo
Isabel
I
Almeida González
Carmen
C
D000367:Age Factors; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D011446:Prospective Studies; D011516:Prothrombin / Q000235:genetics*; D012307:Risk Factors; D020246:Venous Thrombosis / Q000235:genetics*
D011516:Prothrombin