No association between coding polymorphism within Exon 4 of the human surfactant protein B gene and pulmonary function in healthy men.
The coding polymorphism (rs1130866) within the surfactant protein B gene is known to associate with certain respiratory abnormalities. We investigated, using spirometry and fluorescence-based PCR, whether this variant influenced pulmonary function in healthy, nonsmoking men. We found no association of pulmonary function with genotype at the rs1130866 locus.
Raleigh
Stuart M
SM
The Biomedical Research Group, Division of Health and Life Sciences, The University of Northampton, UK. stuart.raleigh@northampton.ac.uk
Davies
Benjamin M
BM
Cleal
David
D
Ribbans
William J
WJ
D000328:Adult; D015331:Cohort Studies; D005091:Exons; D005541:Forced Expiratory Volume / Q000235:genetics; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000502:physiology*; D037701:Pulmonary Surfactant-Associated Protein B / Q000235:genetics / Q000502:physiology; D011663:Pulmonary Surfactants / Q000378:metabolism; D012123:Pulmonary Ventilation / Q000235:genetics*; D014797:Vital Capacity / Q000235:genetics
D037701:Pulmonary Surfactant-Associated Protein B; D011663:Pulmonary Surfactants