Association study of a functional variant in intron 8 of the dopamine transporter gene and migraine susceptibility.
Migraine is a common, genetically influenced neurovascular disorder. The dopamine transporter gene is a candidate for migraine association studies. This study tested a functionally linked variable number tandem repeat (VNTR) in intron 8 of the dopamine transporter gene (DAT(Int8)) in 550 migraine cases (401 with aura, 149 without aura) and 550 non-migraine controls. Chi-squared analysis of the DAT(Int8) revealed that the allele and genotype frequency distributions for migraine cases (including subtype analysis) and controls were not different (P > 0.1). These findings offer no evidence for an association of the DAT(Int8) with migraine with and without aura and therefore do not implicate the dopamine transporter gene as a modifier of migraine risk.
McCallum
L K
LK
Environmental Science and Research Ltd, Wellington, New Zealand.
Fernandez
F
F
Quinlan
S
S
Macartney
D P
DP
Lea
R A
RA
Griffiths
L R
LR
D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D050483:Dopamine Plasma Membrane Transport Proteins / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D007438:Introns / Q000235:genetics*; D008297:Male; D008881:Migraine Disorders / Q000235:genetics*; D018598:Minisatellite Repeats / Q000235:genetics
D050483:Dopamine Plasma Membrane Transport Proteins