Exposure to magnetic fields and survival after diagnosis of childhood leukemia: a German cohort study.
Inspired by a recent U.S. study showing poorer survival among children with acute lymphoblastic leukemia (ALL) exposed to magnetic fields above 0.3 microT, we examine this relationship in a German cohort of childhood leukemia cases derived from previous population-based case-control studies conducted between 1992 and 2001. A total of 595 ALL cases with 24-h magnetic field measurements are included in the analysis with a median follow-up of 9.5 years. We calculate the hazard ratios (HR) using the Cox proportional hazards model for overall survival, adjusted for age at diagnosis, calendar year of diagnosis, and gender. Elevated hazards are found for exposures between 0.1 and 0.2 microT [HR, 2.6; 95% confidence interval (95% CI), 1.3-5.2], based on 34 cases with 9 deaths as well as for exposures above 0.2 microT (HR, 1.6; 95% CI, 0.6-4.4), based on 18 cases with 4 deaths. After adjustment for prognostic risk group, the hazard for exposures above 0.2 microT increases to HR, 3.0 (95% CI, 0.9-9.8). In conclusion, this study is generally consistent with the previous finding; however, we report the excess risk at field levels lower than those in the U.S. study. In all, the evidence is still based on small numbers, and a biological mechanism to explain the findings is not known.
Svendsen
Anne Louise
AL
Institute of Cancer Epidemiology, Danish Cancer Society, Strandboulevarden 49, DK-2100 Copenhagen, Denmark.
Weihkopf
Thomas
T
Kaatsch
Peter
P
Schüz
Joachim
J
D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D015331:Cohort Studies; D004574:Electromagnetic Fields / Q000009:adverse effects*; D004781:Environmental Exposure / Q000009:adverse effects*; D005260:Female; D005858:Germany; D006801:Humans; D007223:Infant; D007938:Leukemia / Q000401:mortality*; D008297:Male; D011379:Prognosis; D012042:Registries; D016019:Survival Analysis