[Evaluation of bone mineral density and its importance for hemodialysis patients].
The aim of the study was to determine the changes in bone mineral density in hemodialysis patients and to evaluate their correlation with disorders of calcium-phosphate metabolism.


METHODS
Data of 82 patients on chronic hemodialysis were analyzed. The patient group consisted of 40 (48.8%) men and 42 (51.2%) women. Clinical and laboratory data were collected from medical records. Bone mineral density was measured by ultrasound (Sahara Hologic densitometer) in the heel area.


RESULTS
The mean age of the patients was 60.13+/-16.02 years. Mean T score was 1.7+/-1.19, mean Z score was 1.076+/-1.2, and mean bone mineral density was 0.393+/-0.0 g/cm2. Women had significantly lower bone mineral density than men (0.361 g/cm2 and 0.425 g/cm2, respectively; P=0.006). Normal bone mineral density, when T score was -1 and more, was observed only in 23 (28%) patients. More than one-third (n=37, 45.1%) of patients were classified as osteopenic (T score between -2.5 and -1) and 22 (26.8%) patients as osteoporotic (T score less than -2.5). Patients with normal bone mineral density were significantly younger than those with decreased bone mineral density (54.7+/-15.48 years vs. 58.76+/-15.76 years and 68.09+/-14.5 years, respectively; P<0.05). Laboratory parameters reflecting calcium-phosphate metabolism did not differ between the groups. A statistically significant correlation was observed between T score, bone mineral density and age (-0.328, P=0.03 and -0.301, P=0.007, respectively), body weight (0.27, P=0.014 and 0.339, P=0.002, respectively), and level of parathyroid hormone (-0.322, P=0.003 and -0.286, P=0.01, respectively).


CONCLUSIONS
In our study, bone mineral density lower than normal was observed in more than half of hemodialysis patients. Low bone mineral density in hemodialysis patients correlated with age, gender, lower body weight, and higher level of parathyroid hormone.
Petrauskiene
Vaida
V
Department of Nephrology, Kaunas University of Medicine, Kaunas, Lithuania. vaida.petrauskiene@gmail.com
Bumblyte
Inga Arūne
IA
Sileikiene
Elvyra
E
Gineikaite
Rūta
R
Burbulyte
Rimante
R
D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001835:Body Weight; D015519:Bone Density; D001851:Bone Diseases, Metabolic / Q000175:diagnosis*; D016009:Chi-Square Distribution; D003720:Densitometry; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000175:diagnosis*; D010281:Parathyroid Hormone / Q000097:blood; D006435:Renal Dialysis; D012737:Sex Factors; D013997:Time Factors
D010281:Parathyroid Hormone