title: Dissolution of xylitol from a food supplement administered with a novel slow-release pacifier: preliminary results.
abstract: OBJECTIVE
  The aim of the study was to monitor the pattern of release and salivary xylitol concentrations during sucking of a slow-release pacifier used to deliver a novel food supplement.
  
  
  METHODS
  The food supplement tablet contained 300 mg xylitol and 0.5 x 10(10) colony-forming units of Bifidobacterium lactis Bb-12 (Bb-12). The reference tablet contained 300 mg xylitol and was used by 10 adults (mean age 32 years) in the study. Whole saliva samples were collected with 2.5 min intervals during pacifier sucking. The salivary xylitol concentrations were determined using an enzyme assay kit.
  
  
  RESULTS
  All subjects showed salivary xylitol concentrations exceeding 1% at least at one collection point. The xylitol and xylitol-Bb-12 tablets showed similar dissolving with no clear concentration peaks (comparison of saliva collection times; p = 0.139).
  
  
  CONCLUSIONS
  Xylitol released from the food supplement, delivered with the novel pacifier, may result in salivary xylitol concentrations high enough to inhibit mutans streptococci in vivo.
authors.affiliation: Korpilahti-Muurame Health Care Center; University of Turku, Finland. teemu.taipale@muurame.fi
authors.forename: T
authors.initials: T
authors.lastname: Taipale
authors.forename: K
authors.initials: K
authors.lastname: Pienihakkinen
authors.forename: P
authors.initials: P
authors.lastname: Alanen
authors.forename: J
authors.initials: J
authors.lastname: Jokela
authors.forename: E
authors.initials: E
authors.lastname: Söderling
mesh_terms: D000328:Adult; D001644:Bifidobacterium; D002327:Cariostatic Agents / Q000032:analysis / Q000493:pharmacokinetics*; D003692:Delayed-Action Preparations; D019587:Dietary Supplements; D004337:Drug Carriers; D004867:Equipment Design; D006801:Humans; D007223:Infant; D041361:Pacifiers; D019936:Probiotics / Q000008:administration & dosage / Q000627:therapeutic use; D012463:Saliva / Q000737:chemistry / Q000378:metabolism; D012995:Solubility; D013391:Sucking Behavior; D013549:Sweetening Agents / Q000032:analysis / Q000493:pharmacokinetics*; D014993:Xylitol / Q000032:analysis / Q000493:pharmacokinetics*
chemical_list: D002327:Cariostatic Agents; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D013549:Sweetening Agents; D014993:Xylitol