title: A follow-up study of Nordic multiple sclerosis candidate gene regions.
abstract: In this study, the results from three Nordic linkage disequilibrium screens in multiple sclerosis (MS) were investigated, in a new sample set of 314 Nordic MS trios from Denmark, Norway, Sweden and Iceland. Among 30 non-HLA and two HLA microsatellite markers individually genotyped, eight markers displayed distorted transmission with uncorrected P-value<0.05, ranked in this order: D6S2443 (6p21.32, HLA class II) (P corrected=0.01), D2S2201 (2p24), D19S552 (19q13), D3S3584 (3q21), D17S975 (17q11), D1S2627 (1p22), D6S273 (6p21.33, HLA class III) and D12S1051 (12q23). These non-HLA regions need further investigation as possible MS candidate gene regions in our population.
authors.affiliation: Danish Multiple Sclerosis Research Centre, Copenhagen, Denmark.
authors.forename: P
authors.initials: P
authors.lastname: Datta
authors.forename: H F
authors.initials: HF
authors.lastname: Harbo
authors.forename: L P
authors.initials: LP
authors.lastname: Ryder
authors.forename: E
authors.initials: E
authors.lastname: Akesson
authors.forename: J
authors.initials: J
authors.lastname: Benedikz
authors.forename: E G
authors.initials: EG
authors.lastname: Celius
authors.forename: O
authors.initials: O
authors.lastname: Andersen
authors.forename: K-M
authors.initials: KM
authors.lastname: Myhr
authors.forename: M
authors.initials: M
authors.lastname: Sandberg-Wollheim
authors.forename: J
authors.initials: J
authors.lastname: Hillert
authors.forename: A
authors.initials: A
authors.lastname: Svejgaard
authors.forename: P S
authors.initials: PS
authors.lastname: Sorensen
authors.forename: A
authors.initials: A
authors.lastname: Spurkland
authors.forename: A
authors.initials: A
authors.lastname: Oturai
mesh_terms: D005500:Follow-Up Studies; D005787:Gene Frequency; D005820:Genetic Testing; D005838:Genotype; D006680:HLA Antigens / Q000235:genetics*; D006801:Humans; D007055:Iceland / Q000453:epidemiology; D015810:Linkage Disequilibrium; D018895:Microsatellite Repeats; D009103:Multiple Sclerosis / Q000208:ethnology* / Q000235:genetics*; D012537:Scandinavian and Nordic Countries / Q000453:epidemiology
chemical_list: D006680:HLA Antigens