title: Characteristics of vulvar squamous cell carcinoma in Japanese women.
abstract: Although the presence of racial differences in vulvar squamous cell carcinomas has been suggested, fully analyzed data concerning such tumors in Japanese women have not been reported. A total of 21 vulvar squamous cell carcinomas of Japanese women who lived in north-east Japan, were studied with respect to histological subtype, HPV, p53 and p16(INK4a). The majority of tumors consisted of keratinizing and non-keratinizing types (16/21, 76%), all of which were negative for HPV. The remaining five tumors of basaloid, warty or verrucous types were positive for HPV. HPV-negative tumors showed a trend of greater accumulation of gene abnormalities, including p53 gene mutation, than HPV-positive ones. p16(INK4a) overexpression was shown to not always be a marker for vulvar squamous cell carcinoma in Japanese women with activated high-risk HPV.
authors.affiliation: Department of Pathology, Yamagata University School of Medicine, Yamagata, Japan. osabe@med.id.yamagata-u.ac.jp
authors.forename: Mitsumasa
authors.initials: M
authors.lastname: Osakabe
authors.forename: Masahiro
authors.initials: M
authors.lastname: Hayashi
authors.forename: Yousei
authors.initials: Y
authors.lastname: Katayama
authors.forename: Iwao
authors.initials: I
authors.lastname: Emura
authors.forename: Keiichi
authors.initials: K
authors.lastname: Nemoto
authors.forename: Hajime
authors.initials: H
authors.lastname: Umezu
authors.forename: Ken
authors.initials: K
authors.lastname: Saitoh
authors.forename: Teiichi
authors.initials: T
authors.lastname: Motoyama
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis; D002294:Carcinoma, Squamous Cell / Q000737:chemistry / Q000453:epidemiology / Q000209:etiology / Q000473:pathology*; D019941:Cyclin-Dependent Kinase Inhibitor p16 / Q000032:analysis / Q000235:genetics; D004273:DNA, Neoplasm / Q000032:analysis; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D007564:Japan / Q000453:epidemiology; D019656:Loss of Heterozygosity; D008875:Middle Aged; D027383:Papillomaviridae / Q000235:genetics / Q000302:isolation & purification; D030361:Papillomavirus Infections / Q000150:complications / Q000453:epidemiology / Q000473:pathology*; D016159:Tumor Suppressor Protein p53 / Q000032:analysis / Q000235:genetics; D014846:Vulvar Neoplasms / Q000737:chemistry / Q000453:epidemiology / Q000209:etiology / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor; D019941:Cyclin-Dependent Kinase Inhibitor p16; D004273:DNA, Neoplasm; D004279:DNA, Viral; D016159:Tumor Suppressor Protein p53