title: [Secondary osteoporosis: Inhaled corticosteroids induced osteoporosis in respiratory diseases].
abstract: Inhalation and oral steroids therapy has been used in the management of asthma, chronic obstructive pulmonary disease (COPD) and interstitial lung disease. This article described the effects of inhaled corticosteroids on bone. Inhaled corticosteroids are the standard of therapy in asthma and are commonly prescribed for chronic obstructive pulmonary disease. Accumulating evidence suggests that the effect of inhaled corticosteroids on bone is not small. Recent studies have shown that long-term use of inhaled corticosteroid at moderate or high doses is also associated with increased risk for the effects of inhaled corticosteroids on bone. Older age, inmobility and steroid treatment are major risk factors of osteoporosis. Treatment with bisphosphonate will be recommended in these patients, so earlier prevention for corticosteroids induced osteoporosis is necessary at administration of inhaled corticosteroids.
authors.affiliation: Kinki University Sakai Hospital, Department of Pulmonary Medicine.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Ieda
authors.forename: Yukio
authors.initials: Y
authors.lastname: Nagasaka
mesh_terms: D000280:Administration, Inhalation; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000009:adverse effects* / Q000493:pharmacokinetics; D001249:Asthma / Q000188:drug therapy*; D001842:Bone and Bones / Q000378:metabolism; D004164:Diphosphonates / Q000627:therapeutic use; D006801:Humans; D010024:Osteoporosis / Q000139:chemically induced* / Q000517:prevention & control; D029424:Pulmonary Disease, Chronic Obstructive / Q000188:drug therapy*
chemical_list: D000305:Adrenal Cortex Hormones; D004164:Diphosphonates