title: Primary paraspinal leiomyosarcoma invading the cervical spinal canal successfully treated with surgery, radiotherapy, and chemotherapy. Case report.
abstract: A primary paraspinal leiomyosarcoma invading the spine is an exceedingly rare neoplasm that may clinically mimic a schwannoma. The authors report a case involving a 45-year-old man with a primary leiomyosarcoma of the cervical paraspinal musculature that invaded the spinal canal at C1-2 and subsequently metastasized to the lungs and pancreas. Aggressive treatment consisting of resection of the primary tumor, adjunctive radiation therapy and chemotherapy, and surgical debulking of metastatic disease resulted in local tumor control at the primary site and long-term survival of the patient.
authors.affiliation: Department of Pathology, Stanford University Medical Center, Stanford, California 94305, USA. nlehman@stanford.edu
authors.forename: Norman L
authors.initials: NL
authors.lastname: Lehman
authors.forename: Charlotte D
authors.initials: CD
authors.lastname: Jacobs
authors.forename: Phillip A
authors.initials: PA
authors.lastname: Holsten
authors.forename: Sivakumar
authors.initials: S
authors.lastname: Jaikumar
authors.forename: Trang D
authors.initials: TD
authors.lastname: Lehman
authors.forename: Iris C
authors.initials: IC
authors.lastname: Gibbs
authors.forename: Lawrence M
authors.initials: LM
authors.lastname: Shuer
mesh_terms: D002574:Cervical Vertebrae / Q000473:pathology; D003131:Combined Modality Therapy; D006801:Humans; D007890:Leiomyosarcoma / Q000473:pathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D013115:Spinal Canal / Q000473:pathology; D013125:Spinal Neoplasms / Q000473:pathology / Q000628:therapy*