title: [Prenatal diagnosis of Thailand deletion of alpha-thalassemia 1].
abstract: OBJECTIVE
  To conduct prenatal diagnosis on the couples carrying Thailand deletion (--THAI) alpha-thalassemia 1 and at high risk of having fetus with alpha-thalassemia.
  
  
  METHODS
  Genotypes of couples and fetuses were analyzed by PCR and DNA sequencing.
  
  
  RESULTS
  Four pregnant women were patients with Hb H diseases of --THAI compounding with alpha-thalassemia 2, while their husbands were heterozygote of the Southeast Asian type alpha-thalassemia 1 (--SEA). Another 5 families, either husbands or wives were heterozygote of --THAI or --SEA. The genotypes of their fetuses were as follows: 2 cases with Hb Bart's hydrops fetalis syndrome, 1 Hb H disease, 4 alpha-thalassemia heterozygote and 2 normal. The DNA sequencing approved the PCR results.
  
  
  CONCLUSIONS
  The study on prenatal diagnosis of Thailand deletion alpha-thalassemia 1 is of importance to the genetic counseling and prenatal diagnosis of alpha-thalassemia.
authors.affiliation: Hemoglobin Laboratory, First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, 530021 PR China. cping62@hotmail.com
authors.forename: Ping
authors.initials: P
authors.lastname: Chen
authors.forename: Shu-quan
authors.initials: SQ
authors.lastname: Li
authors.forename: Min-qing
authors.initials: MQ
authors.lastname: Li
authors.forename: Li-hong
authors.initials: LH
authors.lastname: Pang
authors.forename: Wei-xiong
authors.initials: WX
authors.lastname: Lin
mesh_terms: D000328:Adult; D001483:Base Sequence; D005260:Female; D005315:Fetal Diseases / Q000097:blood / Q000175:diagnosis* / Q000235:genetics*; D005838:Genotype; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D008297:Male; D011247:Pregnancy; D011296:Prenatal Diagnosis; D017422:Sequence Analysis, DNA; D017384:Sequence Deletion / Q000235:genetics*; D017085:alpha-Thalassemia / Q000097:blood / Q000175:diagnosis* / Q000235:genetics*
chemical_list: D006454:Hemoglobins