title: A review of bisphosphonate-associated osteonecrosis of the jaws and its management.
abstract: Bisphosphonate-associated osteonecrosis (BON) may result in serious oral complications, such as osteomyelitis and chronic exposure of necrotic bone. Dentists must be familiar with this disorder and pay special attention to all patients on bisphosphonate therapy due to their defective osteoclast function and reduced osseous tissue vascularity, leading to impaired wound healing. The purpose of this paper is to review the history and pathogenesis of BON, discuss its differential diagnosis, provide guidance to dentists on possible measures to prevent BON and review the management of patients with BON.
authors.affiliation: Division of Oral and Maxillofacial Surgery and Anesthesia, Mount Sinai Hospital.
authors.forename: David K
authors.initials: DK
authors.lastname: Lam
authors.forename: George K B
authors.initials: GK
authors.lastname: Sándor
authors.forename: Howard I
authors.initials: HI
authors.lastname: Holmes
authors.forename: A Wayne
authors.initials: AW
authors.lastname: Evans
authors.forename: Cameron M L
authors.initials: CM
authors.lastname: Clokie
mesh_terms: D050071:Bone Density Conservation Agents / Q000009:adverse effects*; D016723:Bone Remodeling / Q000187:drug effects; D024042:Collagen Type I / Q000032:analysis; D000075202:Contraindications; D004164:Diphosphonates / Q000009:adverse effects*; D006801:Humans; D007571:Jaw Diseases / Q000139:chemically induced* / Q000628:therapy; D018919:Neovascularization, Physiologic / Q000187:drug effects; D019647:Oral Surgical Procedures; D010020:Osteonecrosis / Q000139:chemically induced* / Q000628:therapy; D010455:Peptides / Q000032:analysis
chemical_list: D050071:Bone Density Conservation Agents; D024042:Collagen Type I; D004164:Diphosphonates; D010455:Peptides; C052929:collagen type I trimeric cross-linked peptide