Cord blood stem cell transplantation. Why it is necessary to establish a Bulgarian cord blood bank?
The allogenic transplantation of hemopoietic stem cell from bone marrow and peripheral blood is limited due to the necessity to identify HLA matched donor within the family or in bone marrow donor registries. Although, more than 10 million donors are available worldwide, completely HLA matched donors could be found only for 75% of the patients. It is well known that transplantations of hematopoietic stem cell from cord blood are characterized with a lower risk of GvHD and therefore do not require so strict criteria for HLA matching, and less time for search of matched donor is needed. The necessity to establish a National cord blood bank in Bulgaria is emphasized further by the heterogeneity of HLA allele and haplotype distribution in the Bulgarian population. That could be explained by the ethnic diversity of the population. As a result some alleles are more frequent in Bulgarians compared to other populations. The organization, accreditation, and development of a strategy for a National cord blood bank will be discussed.
Zlatev
Asen
A
Central Laboratory of Clinical Immunology, University Hospital Alexandrovska, Sofia, 1431, Bulgaria.
Mihaylova
Anastasia
A
Baltadjieva
Daniela
D
Ivanova
Milena
M
Naumova
Elissaveta
E
D001771:Blood Banks / Q000600:supply & distribution*; D002031:Bulgaria; D036101:Cord Blood Stem Cell Transplantation / Q000706:statistics & numerical data*; D005843:Geography; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; D006239:Haplotypes; D006801:Humans
D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains