Hyperadrenocorticism associated with sex steroid excess.
Diagnosis of sex steroid excess or hyperadrenocorticism in dogs may be challenging. Unlike Cushing's disease, sex steroid excess may have a multitude of manifestations that differ from standard hyperadrenocorticism. In particular, the clinical scenario of a dog with sex steroid imbalance involves one of three systems: dermatologic, reproductive, or hepatic. The history of a dog with hyperadrenocorticism manifesting as sex steroid imbalance often lacks the classical clinical signs of polydipsia and polyuria. Dogs with sex steroid imbalance will often be of specific breeds such as miniature poodles and exhibit trunkal hair loss as the only sign. There is often involvement of the reproductive system, manifested as the growth of perianal adenomas in neutered male or female dogs. The most common laboratory findings consist of elevations in serum alkaline phosphatase and serum alanine transferase. The following article reviews the etiology, common signalment, clinical signs, and laboratory findings associated with atypical hyperadrenocorticism caused by sex steroid imbalance and then explores the medical, surgical, and radiation treatment options.
Greco
Deborah S
DS
Nestle Purina Petcare, One Checkerboard Square, St. Louis, MO 63164, USA. Deborah.greco@rdmo.nestle.com
D000308:Adrenocortical Hyperfunction / Q000097:blood / Q000473:pathology / Q000628:therapy / Q000662:veterinary*; D000367:Age Factors; D000818:Animals; D003480:Cushing Syndrome / Q000097:blood / Q000473:pathology / Q000628:therapy / Q000662:veterinary*; D004283:Dog Diseases / Q000097:blood* / Q000473:pathology / Q000628:therapy; D004285:Dogs; D005260:Female; D012739:Gonadal Steroid Hormones / Q000097:blood*; D006854:Hydrocortisone / Q000097:blood; D008297:Male
D012739:Gonadal Steroid Hormones; D006854:Hydrocortisone