title: Accuracy of nonstenotic coronary atherosclerosis assessment by multi-detector computed tomography.
abstract: BACKGROUND
  The ability to evaluate coronary stenosis using multi-detector computed tomography (MDCT) has been well discussed. In contrast, several studies demonstrated that the plaque burden measured by intravascular ultrasound (IVUS) has a relationship to the risk of cardiovascular events. the accuracy of MDCT was studied to determine plaque and vessel size compared with IVUS.
  
  
  RESULTS
  Fifty-six proximal lesions (American College of Cardiology/American Heart Association classification: segment 1, 5, 6) from 33 patients were assessed using MDCT and IVUS. The plaque and vessel area were measured from the cross-sectional image using both MDCT and IVUS. Eight coronary artery lesions with motion artifacts and heavily calcified plaques were excluded from the analysis. The vessel and lumen size evaluated using MDCT were closely correlated with those evaluated by IVUS (R(2)=0.614, 0.750 respectively). Furthermore, there was a strong correlation between percentage plaque area assessed by MDCT and IVUS (R(2)=0.824).
  
  
  CONCLUSIONS
  MDCT can noninvasively quantify coronary atherosclerotic plaque with good correlation compared with IVUS in patients with atherosclerosis.
authors.affiliation: Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan. thara@med.kobe-u.ac.jp
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Hara
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Yamada
authors.forename: Takatoshi
authors.initials: T
authors.lastname: Hayashi
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Ikeda
authors.forename: Kohei
authors.initials: K
authors.lastname: Yamashiro
authors.forename: Kazuo
authors.initials: K
authors.lastname: Mizutani
authors.forename: Sachiyo
authors.initials: S
authors.lastname: Iwata
authors.forename: Katsunori
authors.initials: K
authors.lastname: Okajima
authors.forename: Yasue
authors.initials: Y
authors.lastname: Tsukishiro
authors.forename: Kensuke
authors.initials: K
authors.lastname: Matsumoto
authors.forename: Takafumi
authors.initials: T
authors.lastname: Akagami
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kumagai
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Kinugasa
authors.forename: Michihiko
authors.initials: M
authors.lastname: Inoue
authors.forename: Naoki
authors.initials: N
authors.lastname: Murai
authors.forename: Ichiro
authors.initials: I
authors.lastname: Izawa
authors.forename: Teishi
authors.initials: T
authors.lastname: Kajiya
mesh_terms: D000368:Aged; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging*; D003331:Coronary Vessels / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed; D018084:Ultrasonography, Interventional