Nonleaching antimicrobial films prepared from surface-modified microfibrillated cellulose.
We have prepared potentially permanent antimicrobial films based on surface-modified microfibrillated cellulose (MFC). MFC, obtained by disintegration of bleached softwood sulfite pulp in a homogenizer, was grafted with the quaternary ammonium compound octadecyldimethyl(3-trimethoxysilylpropyl)ammonium chloride (ODDMAC) by a simple adsorption-curing process. Films prepared from the ODDMAC-modified MFC were characterized by Fourier transform infrared spectroscopy (FT-IR) and X-ray photoelectron spectroscopy (XPS) and tested for antibacterial activity against the Gram-positive bacterium Staphylococcus aureus and the Gram-negative bacteria Escherichia coli and Pseudomonas aeruginosa. The films showed substantial antibacterial capacity even at very low concentrations of antimicrobial agent immobilized on the surface. A zone of inhibition test demonstrated that no ODDMAC diffused into the surroundings, verifying that the films were indeed of the nonleaching type.
Andresen
Martin
M
Ugelstad Laboratory, Department of Chemical Engineering, Norwegian University of Science and Technology, Trondheim, Norway. martinan@chemeng.ntnu.no
Stenstad
Per
P
Møretrø
Trond
T
Langsrud
Solveig
S
Syverud
Kristin
K
Johansson
Leena-Sisko
LS
Stenius
Per
P
D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D002482:Cellulose / Q000737:chemistry*; D004926:Escherichia coli / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D008855:Microscopy, Electron, Scanning; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013055:Spectrophotometry, Infrared; D017550:Spectroscopy, Fourier Transform Infrared; D013211:Staphylococcus aureus / Q000187:drug effects; D013499:Surface Properties
D000900:Anti-Bacterial Agents; D002482:Cellulose