title: Characterization of brain metastases using high-resolution magic angle spinning MRS.
abstract: The objectives of this study were to (a) explore the spectral characteristics of brain metastases, focusing on the origin of the primary cancer, and (b) evaluate the correlation with clinical outcome using multivariate analysis. High-resolution magic angle spinning (HR-MAS) MR spectra (n = 26) were obtained from 16 patients with brain metastases using a Bruker Avance DRX600 instrument. Standard pulse-acquired and spin-echo (TE 32 and 285 ms) (1)H spectra were obtained. These were examined using principal component analysis (PCA) and partial least squares regression analysis (PLS) relating spectral data to clinical outcome. The PCA score plot of pulse-acquired HR-MAS spectra showed a trend of clustering due to the origin of the metastases, mainly based on differences in the lipid signals at 1.3 and 0.9 ppm. With PLS, spectra of patients who died less than 5 months after surgery appeared to cluster in the lower left quadrant of the score plot. These preliminary results on brain metastasis classification and prediction of survival must be validated in a larger patient cohort. However, the possibility of differentiating metastases according to origin and predicting survival on the basis of HR-MAS spectra suggests that this method may be useful for diagnosing and planning treatment for brain metastases and also for guiding decisions about terminating further treatment.
authors.affiliation: Department of Neuromedicine, Norwegian University of Science and Technology, Trondheim, Norway. Torill.Sjobakk@ntnu.no
authors.forename: Torill E
authors.initials: TE
authors.lastname: Sjøbakk
authors.forename: Roar
authors.initials: R
authors.lastname: Johansen
authors.forename: Tone F
authors.initials: TF
authors.lastname: Bathen
authors.forename: Ursula
authors.initials: U
authors.lastname: Sonnewald
authors.forename: Roar
authors.initials: R
authors.lastname: Juul
authors.forename: Sverre H
authors.initials: SH
authors.lastname: Torp
authors.forename: Steinar
authors.initials: S
authors.lastname: Lundgren
authors.forename: Ingrid S
authors.initials: IS
authors.lastname: Gribbestad
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000401:mortality / Q000556:secondary; D016000:Cluster Analysis; D005260:Female; D006801:Humans; D016018:Least-Squares Analysis; D008055:Lipids / Q000032:analysis; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D025341:Principal Component Analysis; D012815:Signal Processing, Computer-Assisted; D016019:Survival Analysis
chemical_list: D014408:Biomarkers, Tumor; D008055:Lipids