title: Surgery versus prolonged conservative treatment for sciatica.
abstract: BACKGROUND
  Lumbar-disk surgery often is performed in patients who have sciatica that does not resolve within 6 weeks, but the optimal timing of surgery is not known.
  
  
  METHODS
  We randomly assigned 283 patients who had had severe sciatica for 6 to 12 weeks to early surgery or to prolonged conservative treatment with surgery if needed. The primary outcomes were the score on the Roland Disability Questionnaire, the score on the visual-analogue scale for leg pain, and the patient's report of perceived recovery during the first year after randomization. Repeated-measures analysis according to the intention-to-treat principle was used to estimate the outcome curves for both groups.
  
  
  RESULTS
  Of 141 patients assigned to undergo early surgery, 125 (89%) underwent microdiskectomy after a mean of 2.2 weeks. Of 142 patients designated for conservative treatment, 55 (39%) were treated surgically after a mean of 18.7 weeks. There was no significant overall difference in disability scores during the first year (P=0.13). Relief of leg pain was faster for patients assigned to early surgery (P<0.001). Patients assigned to early surgery also reported a faster rate of perceived recovery (hazard ratio, 1.97; 95% confidence interval, 1.72 to 2.22; P<0.001). In both groups, however, the probability of perceived recovery after 1 year of follow-up was 95%.
  
  
  CONCLUSIONS
  The 1-year outcomes were similar for patients assigned to early surgery and those assigned to conservative treatment with eventual surgery if needed, but the rates of pain relief and of perceived recovery were faster for those assigned to early surgery. (Current Controlled Trials number, ISRCTN26872154 [controlled-trials.com].).
authors.affiliation: Department of Neurosurgery, Leiden University Medical Center, Leiden, The Netherlands. w.c.peul@lumc.nl
authors.forename: Wilco C
authors.initials: WC
authors.lastname: Peul
authors.forename: Hans C
authors.initials: HC
authors.lastname: van Houwelingen
authors.forename: Wilbert B
authors.initials: WB
authors.lastname: van den Hout
authors.forename: Ronald
authors.initials: R
authors.lastname: Brand
authors.forename: Just A H
authors.initials: JA
authors.lastname: Eekhof
authors.forename: Joseph T J
authors.initials: JT
authors.lastname: Tans
authors.forename: Ralph T W M
authors.initials: RT
authors.lastname: Thomeer
authors.forename: Bart W
authors.initials: BW
authors.lastname: Koes
mesh_terms: D000328:Adult; D019540:Area Under Curve; D004185:Disability Evaluation; D017586:Diskectomy; D005260:Female; D006801:Humans; D007405:Intervertebral Disc Displacement / Q000150:complications / Q000601:surgery* / Q000628:therapy; D053208:Kaplan-Meier Estimate; D008159:Lumbar Vertebrae / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D026741:Physical Therapy Modalities; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012585:Sciatica / Q000209:etiology / Q000601:surgery* / Q000628:therapy; D016896:Treatment Outcome