title: Deregulated over expression of FOXP1 protein in diffuse large B-cell lymphoma does not occur as a result of gene rearrangement.
abstract: Strong uniform expression of FOXP1 protein occurs in a subgroup of non-germinal centre (GC) diffuse large B-cell lymphomas (DLBCL). We have investigated gene rearrangement as a potential mechanism for deregulated expression of FOXP1 however, using FISH FOXP1 translocations were not found in any case with over-expression of the protein.
authors.forename: Sharon L
authors.initials: SL
authors.lastname: Barrans
authors.forename: James A L
authors.initials: JA
authors.lastname: Fenton
authors.forename: Roland
authors.initials: R
authors.lastname: Ventura
authors.forename: Alex
authors.initials: A
authors.lastname: Smith
authors.forename: Alison H
authors.initials: AH
authors.lastname: Banham
authors.forename: Andrew S
authors.initials: AS
authors.lastname: Jack
mesh_terms: D051858:Forkhead Transcription Factors / Q000032:analysis / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic; D015321:Gene Rearrangement; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D016393:Lymphoma, B-Cell / Q000235:genetics; D016403:Lymphoma, Large B-Cell, Diffuse / Q000235:genetics*; D012097:Repressor Proteins / Q000032:analysis / Q000235:genetics*
chemical_list: C486626:FOXP1 protein, human; D051858:Forkhead Transcription Factors; D012097:Repressor Proteins