title: An electrospray ionisation tandem mass spectrometric investigation of selected psychoactive pharmaceuticals and its application in drug and metabolite profiling by liquid chromatography/electrospray ionisation tandem mass spectrometry.
abstract: A tandem mass spectrometric investigation of the collision-induced dissociation of five commonly prescribed psychoactive pharmaceuticals, risperidone, sertraline, paroxetine, trimipramine, and mirtazapine, and their metabolites has been carried out. Quadrupole ion trap mass spectrometry was employed to generate tandem mass spectrometric (MS/MS) data of the compounds under investigation and structural assignments of product ions were supported by quadrupole time-of-flight mass spectrometry. These fragmentation studies were then utilised in the development of a liquid chromatographic method to identify the drugs and their metabolites in human hair and saliva samples, thus providing relevant profiling information.
authors.affiliation: School of Biomedical Sciences, University of Ulster, Coleraine BT52 1SA, UK.
authors.forename: Bernadette
authors.initials: B
authors.lastname: Doherty
authors.forename: Virginia
authors.initials: V
authors.lastname: Rodriguez
authors.forename: Julian C
authors.initials: JC
authors.lastname: Leslie
authors.forename: Stephen
authors.initials: S
authors.lastname: McClean
authors.forename: W Franklin
authors.initials: WF
authors.lastname: Smyth
mesh_terms: D014150:Antipsychotic Agents / Q000032:analysis* / Q000737:chemistry / Q000378:metabolism; D002853:Chromatography, Liquid / Q000379:methods*; D006197:Hair / Q000737:chemistry; D006801:Humans; D015394:Molecular Structure; D012463:Saliva / Q000737:chemistry; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods*; D053719:Tandem Mass Spectrometry / Q000379:methods*
chemical_list: D014150:Antipsychotic Agents