title: Predicting the need for fundoplication at the time of congenital diaphragmatic hernia repair.
abstract: OBJECTIVE
  This study was conducted to examine the preoperative factors predictive of subsequent intervention for gastroesophageal reflux (GER) in children with congenital diaphragmatic hernia (CDH).
  
  
  METHODS
  We conducted a retrospective cohort study on children who underwent repair of a CDH between January 1, 1995, and December 31, 2002 with follow-up continuing to September 1, 2005. Excluded in the study were children who died during their first admission, or who underwent fundoplication at the time of CDH repair. Univariate and multivariate logistic regressions were performed to examine preoperative factors predictive of subsequent intervention (fundoplication or gastrojejunal tube placement).
  
  
  RESULTS
  Of 86 children, 13 underwent intervention (fundoplication, 10; gastrojejunal tube, 3) for GER. Univariate predictors included the following: right-sided CDH, use of nonconventional ventilation, liver within the chest, and patch closure of the CDH. However, only liver within the chest and patch closure of the CDH were significant predictors in a multiple variable analysis. The positive and negative predictive values of the multivariate model were 69.2% and 87.7%, respectively.
  
  
  CONCLUSIONS
  Infants with CDH who have liver within the chest or require patch closure of their hernia are at increased risk for subsequent intervention for GER. These children may represent a subpopulation that would benefit from fundoplication at the time of CDH repair.
authors.affiliation: Division of General Surgery, The Hospital for Sick Children, Toronto, Canada M5G 1X8.
authors.forename: Ivan R
authors.initials: IR
authors.lastname: Diamond
authors.forename: Kandice
authors.initials: K
authors.lastname: Mah
authors.forename: Peter C W
authors.initials: PC
authors.lastname: Kim
authors.forename: Desmond
authors.initials: D
authors.lastname: Bohn
authors.forename: J Ted
authors.initials: JT
authors.lastname: Gerstle
authors.forename: Paul W
authors.initials: PW
authors.lastname: Wales
mesh_terms: D015331:Cohort Studies; D003131:Combined Modality Therapy; D004750:Enteral Nutrition; D005260:Female; D005500:Follow-Up Studies; D018662:Fundoplication; D005764:Gastroesophageal Reflux / Q000188:drug therapy / Q000209:etiology / Q000601:surgery*; D006548:Hernia, Diaphragmatic / Q000601:surgery*; D065630:Hernias, Diaphragmatic, Congenital; D006801:Humans; D007231:Infant, Newborn; D008099:Liver / Q000601:surgery; D008297:Male; D015999:Multivariate Analysis; D011183:Postoperative Complications / Q000209:etiology / Q000601:surgery*; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D012307:Risk Factors; D013526:Surgical Mesh