6450 nm wavelength tissue ablation using a nanosecond laser based on difference frequency mixing and stimulated Raman scattering.
A four-stage laser system was developed, emitting at a wavelength of 6450 nm with a 3-5 ns pulse duration, < or = 2 mJ pulse energy, and 1/2 Hz pulse repetition rate. The laser system successfully ablated rat brain tissue, where both the collateral damage and the ablation rate compare favorably with that previously observed with a Mark-III Free-Electron Laser.
Edwards
G S
GS
Free-Electron Laser Laboratory, Duke University, Durham, North Carolina 27708, USA. edwards@fel.duke.edu
Pearlstein
R D
RD
Copeland
M L
ML
Hutson
M S
MS
Latone
K
K
Spiro
A
A
Pasmanik
G
G
D000818:Animals; D001921:Brain / Q000378:metabolism / Q000473:pathology; D004583:Electrons; D004867:Equipment Design; D007834:Lasers; D055095:Optics and Photonics; D009991:Oscillometry; D051381:Rats; D017207:Rats, Sprague-Dawley; D012542:Scattering, Radiation; D013059:Spectrum Analysis, Raman / Q000379:methods*; D013997:Time Factors