Anti-Müllerian hormone substance from follicular fluid is positively associated with success in oocyte fertilization during in vitro fertilization.
OBJECTIVE
To determine whether the anti-Müllerian hormone (AMH) level in follicular fluid is associated with success in oocyte fertilization during in vitro fertilization (IVF) cycles.


METHODS
Retrospective study.


METHODS
Tokyo Medical University hospital.


METHODS
Thirty-one women undergoing IVF cycles.


METHODS
The women were divided into two groups according to the success or failure of fertilization. Follicular fluid samples were obtained from a single follicle in each patient.


METHODS
Assessment of values for AMH, inhibin B, and estradiol from follicular fluid and serum on the day of oocyte retrieval during IVF treatment.


RESULTS
The follicular fluid AMH levels from fertilized patients (group 1) were 3.42 times higher than from nonfertilized (group 2). There was no correlation between the ratio of the high quality grade embryos and either serum AMH or inhibin B levels. There was no statistically significant correlation between serum AMH and the number of oocytes. However, there was a strong correlation between levels of serum estradiol, inhibin B, and the number of oocytes.


CONCLUSIONS
Oocytes are more likely to be fertilized when follicles are able to make high concentrations of AMH in the follicular fluid. Thus, AMH could be a prediction marker for fertilization.
Takahashi
Chie
C
Department of Obstetrics and Gynecology, Tokyo Medical University, Tokyo, Japan. chie@tokyo-med.ac.jp
Fujito
Atsuya
A
Kazuka
Masahiro
M
Sugiyama
Rie
R
Ito
Hiroe
H
Isaka
Keiichi
K
D000328:Adult; D054304:Anti-Mullerian Hormone / Q000032:analysis* / Q000097:blood; D046149:Embryo Culture Techniques; D004958:Estradiol / Q000032:analysis / Q000097:blood; D005260:Female; D005307:Fertilization in Vitro; D015571:Follicular Fluid / Q000737:chemistry*; D006801:Humans; D007265:Inhibins / Q000032:analysis / Q000097:blood; D054315:Oocyte Retrieval; D011247:Pregnancy; D012189:Retrospective Studies; D017211:Treatment Failure; D016896:Treatment Outcome
C422364:inhibin B; D004958:Estradiol; D007265:Inhibins; D054304:Anti-Mullerian Hormone