Review of physiological motor outcome measures in spinal cord injury using transcranial magnetic stimulation and spinal reflexes.
This article reviews methods that have been developed as part of a clinical initiative on improving outcome measures for motor function assessment in subjects with spinal cord injury (SCI). Physiological motor outcome measures originally developed for limbs-transcranial magnetic stimulation (TMS) of the motor cortex to elicit motor-evoked potentials (MEPs) and mechanical stimulation to elicit spinal reflexes-have been extended to muscles of the trunk. The impetus for this development is the lack of a motor component in the American Spinal Injury Association clinical assessment for the thoracic myotomes. The application of TMS to the assessment of limb muscles is reviewed, followed by consideration of its application to the assessment of paravertebral and intercostal muscles. Spinal reflex testing of paravertebral muscles is also described. The principal markers for the thoracic SCI motor level that have emerged from this clinical initiative are (1) the threshold of MEPs in paravertebral muscles in response to TMS of the motor cortex, (2) the facilitation pattern and latency of MEPs in intercostal muscles during voluntary expiratory effort, and (3) the absence of long-latency reflex responses and the exaggeration of short-latency reflex responses in paravertebral muscles.
Ellaway
Peter H
PH
Division of Neuroscience and Mental Health, Imperial College London, Charing Cross Campus, St Dunstan's Rd, London W6 8RP, UK. p.ellaway@imperial.ac.uk
Catley
Maria
M
Davey
Nick J
NJ
Kuppuswamy
Annapoorna
A
Strutton
Paul
P
Frankel
Hans L
HL
Jamous
Ali
A
Savic
Gordana
G
D019054:Evoked Potentials, Motor / Q000502:physiology*; D006801:Humans; D018482:Muscle, Skeletal / Q000502:physiology; D017063:Outcome Assessment, Health Care; D012720:Severity of Illness Index; D013119:Spinal Cord Injuries / Q000534:rehabilitation*; D050781:Transcranial Magnetic Stimulation