Screening for SNPs and haplotypes in the CYP3A7 gene in Chinese populations.
OBJECTIVE
To determine the frequencies and haplotypes of the cytochrome P450 (CYP)3A7 gene in three Chinese ethnic groups, namely, Han, She and Dong.


METHODS
SNP analyses of the CYP3A7 gene were carried out on three groups of healthy Chinese subjects consisting of 539 Han, 264 She and 273 Dong subjects, using direct sequencing. Linkage disequilibrium, haplotype inference and Hardy-Weinberg equilibrium were also determined for these samples.


RESULTS
Significant differences were observed in the distribution of SNP rs2257401 (CYP3A7*2), SNP 1227 T>C (Novel), SNP rs4646468 and SNP rs10211 between the Han, She and Dong groups.


CONCLUSIONS
Some allele and haplotype frequencies show variation among groups, highlighting the need to analyze clinically relevant SNPs and haplotypes in a variety of different racial groups within the Chinese population as well as in other ethnic groups. These results suggest that genetic polymorphisms in the CYP3A7 gene in the Han, She and Dong populations may contribute to interindividual as well as intra-ethnic differences in response to the clearance of CYP3A7 substrates.
Du
Jing
J
Bio-X Center, Shanghai JiaoTong University, 1954 Huashan Road, Shanghai 200030, China.
Shi
Yongyong
Y
Zhang
Aiping
A
Wang
Lei
L
Xuan
Jiekun
J
He
Guang
G
Xu
Lingyun
L
Xu
Mingsheng
M
Shu
Anli
A
Yu
Lan
L
Li
Xingwang
X
Meng
Junwei
J
Feng
Guoyin
G
Xing
Qinghe
Q
He
Lin
L
D000328:Adult; D001189:Aryl Hydrocarbon Hydroxylases / Q000032:analysis* / Q000235:genetics* / Q000378:metabolism; D044466:Asian People / Q000235:genetics*; D051544:Cytochrome P-450 CYP3A; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D005820:Genetic Testing / Q000379:methods*; D006239:Haplotypes / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D013379:Substrate Specificity / Q000235:genetics
D001189:Aryl Hydrocarbon Hydroxylases; C103123:CYP3A7 protein, human; D051544:Cytochrome P-450 CYP3A