Diagnostic biomarker of asbestos-related mesothelioma: example of translational research.
Mesothelioma is an aggressive tumor arising from the mesothelium, and is usually associated with previous exposure to asbestos. The incubation period of asbestos-related mesothelioma is estimated to be approximately 30-40 years. Once mesothelioma has occurred, there is no effective treatment. So, identification of tumor markers and a method for early diagnosis using such markers are urgently needed. Recently, several enzyme-linked immunosorbent assay systems for Erc/mesothelin have been developed, the reported usefulness of which has been assessed and demonstrated as a diagnostic tool. Asbestos-related mesothelioma should be ascribed as a typical environmental carcinogen. In this review, we will present asbestos-related mesothelioma for the study of problems in environmental carcinogenesis.
Okio
Hino
H
Department of Pathology and Oncology, Juntendo University School of Medicine, 2-1-1 Hongo, Tokyo, Japan. ohino@med.juntendo.ac.jp
Kazu
Shiomi
S
Masahiro
Maeda
M
D000818:Animals; D001194:Asbestos / Q000633:toxicity*; D014408:Biomarkers, Tumor / Q000032:analysis*; D004781:Environmental Exposure; D004797:Enzyme-Linked Immunosorbent Assay; D058851:GPI-Linked Proteins; D008175:Lung Neoplasms / Q000209:etiology*; D008562:Membrane Glycoproteins / Q000032:analysis*; D000090204:Mesothelin; D008654:Mesothelioma / Q000139:chemically induced* / Q000209:etiology*; D015513:Oncogene Proteins / Q000032:analysis*; D010534:Peritoneal Neoplasms / Q000209:etiology*; D010997:Pleural Neoplasms / Q000209:etiology*; D051381:Rats
D014408:Biomarkers, Tumor; C413325:Erc protein, human; D058851:GPI-Linked Proteins; D008562:Membrane Glycoproteins; C000715529:Msln protein, rat; D015513:Oncogene Proteins; D001194:Asbestos; D000090204:Mesothelin