title: Successful treatment of extramedullary gastric plasmacytoma with the combination of bortezomib and dexamethasone: first reported case.
abstract: We report a case of a 68-year-old man presented with upper-gastrointestinal bleeding. Endoscopy showed a large ulcerated gastric mass. Histological examination of the gastric biopsies revealed a k monoclonal extramedullary plasmacytoma (EMP). Further staging was negative for multiple myeloma. The patient was managed with bortezomib at a dose of 1.3mg/m2 on days 1, 4, 8 and 11 of a 21-day cycle in combination with dexamethasone 20mg p.o. on days 1, 2, 4, 5, 8, 9 and 11, 12 of each cycle. After 4 cycles of treatment, no endoscopic or histological findings of EMP were found. Thirteen months after diagnosis the patient is in complete remission with no evidence of local relapse or evolution to multiple myeloma. This is the first reported case of EMP successfully managed with the combination of bortezomib and dexamethasone.
authors.affiliation: Theagenion Cancer Center, Hematology, Eyrygeni 6B, 54249 Thessaloniki, Greece. ikatodritou@otenet.gr
authors.forename: Eirini
authors.initials: E
authors.lastname: Katodritou
authors.forename: Charalambos
authors.initials: C
authors.lastname: Kartsios
authors.forename: Vassiliki
authors.initials: V
authors.lastname: Gastari
authors.forename: Evgenia
authors.initials: E
authors.lastname: Verrou
authors.forename: Dimitra
authors.initials: D
authors.lastname: Mihou
authors.forename: Anastasia
authors.initials: A
authors.lastname: Banti
authors.forename: Georgia
authors.initials: G
authors.lastname: Lazaraki
authors.forename: Anna
authors.initials: A
authors.lastname: Lazaridou
authors.forename: Vassiliki
authors.initials: V
authors.lastname: Kaloutsi
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Zervas
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001897:Boronic Acids / Q000008:administration & dosage; D000069286:Bortezomib; D003907:Dexamethasone / Q000008:administration & dosage; D006801:Humans; D008297:Male; D008875:Middle Aged; D010954:Plasmacytoma / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D011719:Pyrazines / Q000008:administration & dosage; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology
chemical_list: D001897:Boronic Acids; D011719:Pyrazines; D000069286:Bortezomib; D003907:Dexamethasone