title: Treatment of mechanical valve thrombosis during pregnancy.
abstract: Pregnant patients with mechanical valves require anticoagulation. The risk of bleeding and embryopathy associated with oral anticoagulation must be weighed against the risk of valve thrombosis. In the presence of a mechanical valve thrombosis, an appropriate treatment modality must be selected, as it is critical for the health of mother and fetus. In this review, we present a pregnant patient with mechanical valve thrombosis (MVT) who underwent thrombolytic therapy, subsequent anticoagulation according to available guidelines, and delivered a healthy baby at full term.
authors.affiliation: Division of Cardiovascular Medicine, University of Florida College of Medicine, Gainesville, Florida 32610-0277, USA.
authors.forename: Calvin
authors.initials: C
authors.lastname: Choi
authors.forename: Scott
authors.initials: S
authors.lastname: Midwall
authors.forename: Peter
authors.initials: P
authors.lastname: Chaille
authors.forename: C R
authors.initials: CR
authors.lastname: Conti
mesh_terms: D000328:Adult; D000925:Anticoagulants / Q000009:adverse effects / Q000627:therapeutic use*; D001803:Blood Transfusion; D002585:Cesarean Section; D005260:Female; D005343:Fibrinolytic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D005865:Gestational Age; D006350:Heart Valve Prosthesis / Q000009:adverse effects*; D006406:Hematoma / Q000139:chemically induced / Q000628:therapy; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D050498:Live Birth; D017410:Practice Guidelines as Topic; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000175:diagnosis / Q000188:drug therapy*; D011994:Recombinant Proteins / Q000627:therapeutic use; D013923:Thromboembolism / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use; D014859:Warfarin / Q000627:therapeutic use
chemical_list: D000925:Anticoagulants; D005343:Fibrinolytic Agents; D011994:Recombinant Proteins; D014859:Warfarin; D006493:Heparin; D010959:Tissue Plasminogen Activator