title: Review article: the role of surgery in gastro-oesophageal reflux disease.
abstract: BACKGROUND
  Rates for laparoscopic fundoplication are declining in the United States and there is no consensus on the indications for referral to surgery in gastro-oesophageal reflux disease.
  
  
  OBJECTIVE
  To highlight recent studies on the outcomes of laparoscopic fundoplication in adults that cast doubt on the traditional indications for surgery in reflux disease.
  
  
  RESULTS
  Patients who are well maintained on medical therapy have more to lose with surgical intervention than to gain, and should not be offered surgery. Likewise, the notion that surgery prevents oesophageal cancer is a hypothesis that is not supported by current evidence, therefore surgical intervention should not be offered to these patients. The only clear-cut candidates for surgery include: patients with anatomic abnormalities such as a large hiatus hernia, or those with persistent regurgitation that causes troublesome symptoms despite medical therapy; and carefully selected patients with extra-oesophageal disorders who have symptoms of reflux disease such as heartburn and regurgitation, an incomplete response to medical therapy and persistent plus demonstrable reflux on pH or impedance testing that is associated with their symptoms. Patients should be aware of the high likelihood of needing continued acid inhibitory therapy following surgery and the possibility of side-effects.
  
  
  CONCLUSIONS
  Only a few carefully selected patients should undergo fundoplication for reflux disease.
authors.affiliation: Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA. nvakil@wisc.edu
authors.forename: N
authors.initials: N
authors.lastname: Vakil
mesh_terms: D000328:Adult; D018662:Fundoplication / Q000009:adverse effects; D005764:Gastroesophageal Reflux / Q000191:economics / Q000601:surgery* / Q000628:therapy; D006801:Humans; D010535:Laparoscopy; D010353:Patient Education as Topic; D011183:Postoperative Complications / Q000517:prevention & control; D054328:Proton Pump Inhibitors; D012307:Risk Factors; D016896:Treatment Outcome
chemical_list: D054328:Proton Pump Inhibitors