[Expression of hypoxia-inducible factor-1alpha in endometriosis].
OBJECTIVE
To detect the expression of hypoxia-inducible factor-1alpha(HIF-1alpha) in endometriosis and explore the possible role of HIF-1alpha in the pathogenesis of endometriosis.


METHODS
Immunohistochemistry was performed to examine the expression of HIF-1alpha in 20 normal endometrium, 20 ectopic endometrium and 68 eutopic endometrium specimens from 68 endometriosis patients, and the results were analyzed statistically.


RESULTS
The expression of HIF-1alpha was significantly increased in ectopic endometrium than in normal endometrium (P<0.01), and the expression did not undergo changes with the normal menstrual cycle in the three types of endometrium.


CONCLUSIONS
HIF-1alpha expression increases in ectopic endometrium, suggesting that HIF-1alpha plays an important role in the pathogenesis of endometriosis.
Ren
Xu
X
Department of Obstetrics and Gynecology, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China. renxu@fimmu.com
He
Yuan-li
YL
Pan
Shi-lei
SL
Peng
Dong-xian
DX
D000328:Adult; D004715:Endometriosis / Q000235:genetics*; D004717:Endometrium / Q000378:metabolism*; D005260:Female; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000235:genetics* / Q000378:metabolism; D008597:Menstrual Cycle / Q000378:metabolism
D051795:Hypoxia-Inducible Factor 1, alpha Subunit