The S447X polymorphism of lipoprotein lipase: effect on the incidence of premature coronary disease and on plasma lipids.
OBJECTIVE
The objective of this study was to evaluate the effect of polymorphism S447X on plasma lipids of patients with premature coronary artery disease (CAD).


METHODS
Plasma lipids and genotypes were determined in 2 groups: 313 patients with premature CAD (<55 years of age) and 150 controls without CAD.


RESULTS
Frequency of the S447X polymorphism was 18% in patients with CAD and 23% in the control group. The S447X polymorphism of lipoprotein lipase is related to a decrease in plasma triglyceride concentrations in male patients with CAD, but this correlation is not observed in female patients.


CONCLUSIONS
The presence of the S447X lipoprotein lipase polymorphism was not associated with the incidence of CAD.
Almeida
Kátia A
KA
Instituto do Coração, Hospital das Clínicas, FM, USP, São Paulo, SP, Brazil.
Strunz
Célia M C
CM
Maranhão
Raul C
RC
Mansur
Antonio P
AP
D000328:Adult; D001938:Brazil / Q000453:epidemiology; D002784:Cholesterol / Q000097:blood; D003324:Coronary Artery Disease / Q000097:blood / Q000453:epidemiology / Q000235:genetics*; D004812:Epidemiologic Methods; D005260:Female; D005838:Genotype; D006801:Humans; D008055:Lipids / Q000097:blood*; D008071:Lipoprotein Lipase / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D012737:Sex Factors; D014280:Triglycerides / Q000097:blood
D008055:Lipids; D014280:Triglycerides; D002784:Cholesterol; D008071:Lipoprotein Lipase