[Correlation between MHC class I-related chain A gene *008 allele and human cytomegalovirus infection].
OBJECTIVE
To investigate the correlation between MHC class I-related chain A (MICA) gene *008 allele and human cytomegalovirus (HCMV) infection.


METHODS
MICA*008 allele was detected in 86 patients with chronic granulocytic leukemia and 81 unrelated normal individuals by way of sequence-specific primers (PCR-SSP). Anti-HCMV IgM was also detected in the sera of these subjects with enzyme linked immunosorbent assay (ELISA).


RESULTS
MICA*008 allele frequency was lower in patients with chronic granulocytic leukemia than in the control group (22.2% vs 34.3%, Chi(2)=4.98, P<0.05). The infection rate of HCMV was significantly higher in those individuals with genotype of MICA*008 (-) than in those with MICA*008 (+), and moderate correlation was suggested between MICA*008 and HCMV infection (C=0.5829, 0.6142).


CONCLUSIONS
Individuals with MICA*008 positivity is not liable to HCMV infection, but those with MICA*008 (-) can be vulnerable to HCMV infection, suggesting an inverse correlation between MICA*008 allele with HCMV.
Huang
Bai-sheng
BS
Department of Physiology, Xiangya School of Medicine, Central South University, Changsha 410078, China. huangbs2078@163.com
Luo
Qi-zhi
QZ
Mei
Bing
B
Yu
Ping
P
D000483:Alleles; D003586:Cytomegalovirus Infections / Q000235:genetics*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics / Q000821:virology
D015395:Histocompatibility Antigens Class I; C099187:MHC class I-related chain A