title: [Effects of Tongxinluo capsule on atherosclerosis obliterans in iliofemoral artery of rabbits].
abstract: OBJECTIVE
  To explore the effects of Tongxinluo capsule (TXL) on the atherosclerosis obliterans (ASO) in iliofemoral artery of rabbits.
  
  
  METHODS
  Rabbits were randomly divided into 7 groups: sham, model, TXL (0.8, 0.4, 0.2 g x kg(-1)), Tongsaimai tablet (0.8 g x kg(-1)) and Laishike (0.002 g x kg(-1)). The animal model of ASO was established with a combined method of mechanical trauma, immunologic injury and high fat fodder feeding. Rabbits were administrated the drugs 8 weeks after surgery. The levels of TC, TG, HDL-C and LDL-C in serum were determined at the time points below: pre-experiment (0 week), pre-drug administration (8 weeks post-surgery), 4 weeks after drug administration (12 weeks post-surgery), 8 weeks after drug administration (16 weeks post-surgery), 12 weeks after drug administration (20 weeks post-surgery). Meanwhile, the behavioral study was performed, the distal skin temperature of the injured hind limb detected. The histopathological changes in iliofemoral artery were examined after opacification.
  
  
  RESULTS
  The levels of TC, TG, LDL-C, VLDL-C and TC/HDL-C were decreased significantly in serum of ASO rabbits. The severity of lameness in the injured hind limb was improved. The distal skin temperature was increased. The thickness and the ratio of intima area of the iliofemoral artery of the injured hind limb were decreased, while the stenosis extent was improved.
  
  
  CONCLUSIONS
  TXL might be beneficial to modulate blood lipid, as well as the prevention and treatment for ASO.
authors.affiliation: Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China. chengren1230@sina.com
authors.forename: Cheng-Ren
authors.initials: CR
authors.lastname: Lin
authors.forename: Xue-Ying
authors.initials: XY
authors.lastname: Ma
authors.forename: Min
authors.initials: M
authors.lastname: Wang
authors.forename: Bai-Xi
authors.initials: BX
authors.lastname: Zhuang
authors.forename: Jian-Xun
authors.initials: JX
authors.lastname: Liu
mesh_terms: D000818:Animals; D001162:Arteriosclerosis Obliterans / Q000097:blood / Q000473:pathology* / Q000517:prevention & control; D001181:Arthropods / Q000737:chemistry; D001522:Behavior, Animal / Q000187:drug effects; D002214:Capsules; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D005263:Femoral Artery / Q000187:drug effects / Q000473:pathology; D007083:Iliac Artery / Q000187:drug effects / Q000473:pathology; D008297:Male; D008419:Materia Medica / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry; D011817:Rabbits; D011897:Random Allocation; D014280:Triglycerides / Q000097:blood; D017539:Tunica Intima / Q000187:drug effects* / Q000473:pathology
chemical_list: D002214:Capsules; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D008419:Materia Medica; D014280:Triglycerides; C513941:tongxinluo; D002784:Cholesterol