Inflammation and the mucosal microcirculation in inflammatory bowel disease: the ebb and flow.
OBJECTIVE
Inflammatory bowel disease pathogenesis involves the interplay of multiple biological factors, among which nonimmune cells, including the endothelium, represent a crucial component of disease pathogenesis.


RESULTS
Endothelial cells play a key role in chronic inflammation through multiple and disparate activities. The mucosal microvasculature in inflammatory bowel disease is dysfunctional, overexpresses inflammatory molecules and undergoes intense angiogenesis, failing to exert its physiological antiinflammatory and anticoagulant activities.


CONCLUSIONS
The mucosal microcirculation is abnormal in inflammatory bowel disease and represents a novel component of disease pathogenesis; targeting the various abnormalities of the inflammatory bowel disease microcirculation may lead to new forms of therapeutic intervention.
Danese
Silvio
S
Division of Gastroenterology, Laboratory of Inflammation and Immunology, IRCCS Istituto Clinico Humanitas, Rozzano, Milan, Italy. sdanese@hotmail.com
D019774:Blood Coagulation Factor Inhibitors / Q000378:metabolism; D001792:Blood Platelets / Q000276:immunology / Q000378:metabolism; D004730:Endothelium, Vascular / Q000276:immunology / Q000378:metabolism; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000276:immunology* / Q000378:metabolism / Q000503:physiopathology*; D007413:Intestinal Mucosa / Q000098:blood supply*; D008833:Microcirculation; D009389:Neovascularization, Pathologic / Q000276:immunology; D012039:Regional Blood Flow; D013601:T-Lymphocytes / Q000276:immunology
D019774:Blood Coagulation Factor Inhibitors