title: A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21.
abstract: We tested 310,605 SNPs for association in 778 individuals with celiac disease and 1,422 controls. Outside the HLA region, the most significant finding (rs13119723; P = 2.0 x 10(-7)) was in the KIAA1109-TENR-IL2-IL21 linkage disequilibrium block. We independently confirmed association in two further collections (strongest association at rs6822844, 24 kb 5' of IL21; meta-analysis P = 1.3 x 10(-14), odds ratio = 0.63), suggesting that genetic variation in this region predisposes to celiac disease.
authors.affiliation: Centre for Gastroenterology, Institute of Cell and Molecular Science, Queen Mary University of London, London E1 2AT, UK. d.vanheel@qmul.ac.uk
authors.forename: David A
authors.initials: DA
authors.lastname: van Heel
authors.forename: Lude
authors.initials: L
authors.lastname: Franke
authors.forename: Karen A
authors.initials: KA
authors.lastname: Hunt
authors.forename: Rhian
authors.initials: R
authors.lastname: Gwilliam
authors.forename: Alexandra
authors.initials: A
authors.lastname: Zhernakova
authors.forename: Mike
authors.initials: M
authors.lastname: Inouye
authors.forename: Martin C
authors.initials: MC
authors.lastname: Wapenaar
authors.forename: Martin C N M
authors.initials: MC
authors.lastname: Barnardo
authors.forename: Graeme
authors.initials: G
authors.lastname: Bethel
authors.forename: Geoffrey K T
authors.initials: GK
authors.lastname: Holmes
authors.forename: Con
authors.initials: C
authors.lastname: Feighery
authors.forename: Derek
authors.initials: D
authors.lastname: Jewell
authors.forename: Dermot
authors.initials: D
authors.lastname: Kelleher
authors.forename: Parveen
authors.initials: P
authors.lastname: Kumar
authors.forename: Simon
authors.initials: S
authors.lastname: Travis
authors.forename: Julian R F
authors.initials: JR
authors.lastname: Walters
authors.forename: David S
authors.initials: DS
authors.lastname: Sanders
authors.forename: Peter
authors.initials: P
authors.lastname: Howdle
authors.forename: Jill
authors.initials: J
authors.lastname: Swift
authors.forename: Raymond J
authors.initials: RJ
authors.lastname: Playford
authors.forename: William M
authors.initials: WM
authors.lastname: McLaren
authors.forename: M Luisa
authors.initials: ML
authors.lastname: Mearin
authors.forename: Chris J
authors.initials: CJ
authors.lastname: Mulder
authors.forename: Ross
authors.initials: R
authors.lastname: McManus
authors.forename: Ralph
authors.initials: R
authors.lastname: McGinnis
authors.forename: Lon R
authors.initials: LR
authors.lastname: Cardon
authors.forename: Panos
authors.initials: P
authors.lastname: Deloukas
authors.forename: Cisca
authors.initials: C
authors.lastname: Wijmenga
mesh_terms: D000818:Animals; D002446:Celiac Disease / Q000235:genetics*; D002894:Chromosomes, Human, Pair 4 / Q000235:genetics; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D015894:Genome, Human; D006801:Humans; D007376:Interleukin-2 / Q000235:genetics*; D007378:Interleukins / Q000235:genetics*; D015810:Linkage Disequilibrium; D051379:Mice; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D000098546:Interleukin-21
chemical_list: D007376:Interleukin-2; D007378:Interleukins; D000098546:Interleukin-21