Mechanisms of HSP72 release.
Currently two mechanisms are recognized by which heat shock proteins (HSP) are released from cells; a passive release mechanism, including necrotic cell death, severe blunt trauma, surgery and following infection with lytic viruses, and an active release mechanism which involves the non classical protein release pathway. HSPs are released both as free HSP and within exosomes. This review covers recent findings on the mechanism by which stress induces the release of HSP72 into the circulation and the biological significance of circulating HSP72 to host defense against disease.
Asea
Alexzander
A
Division of Investigative Pathology, Scott and White Clinic, Texas A&M University System Health Science Center College of Medicine, 2401 South 31st Street, Temple, TX 76508, USA. asea@medicine.tamhsc.edu
D000818:Animals; D050884:HSP72 Heat-Shock Proteins / Q000378:metabolism*; D006801:Humans; D009369:Neoplasms / Q000378:metabolism; D013312:Stress, Physiological
D050884:HSP72 Heat-Shock Proteins