title: Preventing the development of chronic pain after orthopaedic surgery with preventive multimodal analgesic techniques.
abstract: The prevalences of complex regional pain syndrome, phantom limb pain, chronic donor-site pain, and persistent pain following total joint arthroplasty are alarmingly high. Central nervous system plasticity that occurs in response to tissue injury may contribute to the development of persistent postoperative pain. Many researchers have focused on methods to prevent central neuroplastic changes from occurring through the utilization of preemptive or preventive multimodal analgesic techniques. Multimodal analgesia allows a reduction in the doses of individual drugs for postoperative pain and thus a lower prevalence of opioid-related adverse events. The rationale for this strategy is the achievement of sufficient analgesia due to the additive effects of, or the synergistic effects between, different analgesics. Effective multimodal analgesic techniques include the use of nonsteroidal anti-inflammatory drugs, local anesthetics, alpha-2 agonists, ketamine, alpha(2)-delta ligands, and opioids.
authors.affiliation: Department of Anesthesiology, Baystate Medical Center, 759 Chestnut Street, Springfield, MA 01199, USA. scott.reuben@bhs.org
authors.forename: Scott S
authors.initials: SS
authors.lastname: Reuben
authors.forename: Asokumar
authors.initials: A
authors.lastname: Buvanendran
mesh_terms: D000082:Acetaminophen / Q000494:pharmacology; D000316:Adrenergic alpha-Agonists / Q000494:pharmacology; D015360:Analgesia, Epidural; D000700:Analgesics / Q000494:pharmacology; D000779:Anesthetics, Local; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000627:therapeutic use; D019643:Arthroplasty, Replacement; D002908:Chronic Disease; D003000:Clonidine / Q000494:pharmacology; D020918:Complex Regional Pain Syndromes / Q000503:physiopathology; D052246:Cyclooxygenase 2 Inhibitors / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D006930:Hyperalgesia / Q000503:physiopathology; D018836:Inflammation Mediators / Q000494:pharmacology; D007649:Ketamine; D009473:Neuronal Plasticity; D009985:Orthopedics; D017288:Pain Threshold / Q000502:physiology; D010149:Postoperative Pain / Q000503:physiopathology / Q000517:prevention & control*; D010591:Phantom Limb / Q000503:physiopathology
chemical_list: D000316:Adrenergic alpha-Agonists; D000700:Analgesics; D000779:Anesthetics, Local; D000894:Anti-Inflammatory Agents, Non-Steroidal; D052246:Cyclooxygenase 2 Inhibitors; D018836:Inflammation Mediators; D000082:Acetaminophen; D007649:Ketamine; D003000:Clonidine