title: Evolving management of newly diagnosed brain metastases: expanding role of radiosurgery in lieu of whole brain radiation.
abstract: The use of stereotactic radiosurgery has grown increasingly prevalent in the management of patients with brain metastases. In this perspective we contend that a large number of patients can be offered the alternative of treatment with this modality alone, reserving whole brain radiation for salvage. The relevant data will be presented supporting this approach, with emphasis on the toxicities of whole brain radiation and equivalence of survival outcomes regardless of treatment approach. Patient selection for radiosurgery alone will also be addressed.
authors.affiliation: Department of Radiation Oncology & Molecular Radiation Sciences, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA. kleinla@jhmi.edu
authors.forename: Jana
authors.initials: J
authors.lastname: Fox
authors.forename: Lawrence
authors.initials: L
authors.lastname: Kleinberg
mesh_terms: D001932:Brain Neoplasms / Q000556:secondary / Q000601:surgery*; D016371:Cranial Irradiation; D019317:Evidence-Based Medicine; D006801:Humans; D016634:Radiosurgery; D015996:Survival Rate; D016896:Treatment Outcome