title: [Case-control study evaluating the incidence of hyperhomocysteinemia in cancer patients in an internal medicine department].
abstract: OBJECTIVE
  Cancer is a cause of venous thromboembolism. However, the physiopathology remains unknown. Hyperhomocysteinemia could be a promoting factor.
  
  
  METHODS
  We built a case-control study of 65 patients followed for 2 years to compare levels of homocystéinémie in cancer bearing patients with that in matched cancer free control patients.
  
  
  RESULTS
  Fifty per cent of cancer bearing patients had significantly increased blood serum levels of homocystéine (P=0.006). This increase did not correlate with any deficiency in blood serum levels of folate or vitamin B12.
  
  
  CONCLUSIONS
  High levels of homocystéinémie could be linked to tumor proliferation.
authors.affiliation: Service de médecine interne et immunologie clinique, hôpital du Bocage, 2, boulevard de Lattre-de-Tassigny, 21030 Dijon cedex, France. nicolas.falvo@chu-dijon.fr
authors.forename: N
authors.initials: N
authors.lastname: Falvo
authors.forename: F
authors.initials: F
authors.lastname: Ghiringhelli
authors.forename: S
authors.initials: S
authors.lastname: Berthier
authors.forename: B
authors.initials: B
authors.lastname: Bonnotte
authors.forename: B
authors.initials: B
authors.lastname: Lorcerie
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D005260:Female; D005500:Follow-Up Studies; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D020138:Hyperhomocysteinemia / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000097:blood*
chemical_list: D006710:Homocysteine