title: The Dim protein family: from structure to splicing.
abstract: The spliceosome is a dynamic macromolecular machine that catalyzes pre-mRNA splicing through a mechanism controlled by several accessory proteins, including the Dim proteins. The Dim protein family is composed of two classes, Dim1 and Dim2, which share a common thioredoxin-like fold. They were originally identified for their role in cell cycle progression and have been found to interact with Prp6, an essential component of the spliceosome, which forms the bridge of U4/U6.U5-tri-snRNP. In spite of their biological and structural similarities, Dim1 and Dim2 proteins differ in many aspects. Dim1 bears distinctive structural motifs responsible for its interaction with other spliceosome components. Dim2 forms homodimers and contains specific domains required for its interactions with partners. This originality suggests that although both proteins are involved in pre-mRNA splicing, they are likely to be involved in different biological pathways. In the present article we review the structure and function of the Dim proteins.
authors.affiliation: Centre de Recherches de Biochimie Macromoléculaire, Department of Molecular Biophysics and Therapeutics, UMR-5237 CNRS, 1919 Route de Mende, 34293, Montpellier, France.
authors.forename: F
authors.initials: F
authors.lastname: Simeoni
authors.forename: G
authors.initials: G
authors.lastname: Divita
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D008780:Methyltransferases / Q000737:chemistry / Q000378:metabolism; D008958:Models, Molecular; D008969:Molecular Sequence Data; D011487:Protein Conformation; D017510:Protein Folding; D012326:RNA Splicing; D017415:Ribonucleoprotein, U5 Small Nuclear / Q000737:chemistry / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000737:chemistry / Q000378:metabolism; D016415:Sequence Alignment
chemical_list: C484364:DIM2 protein, S cerevisiae; D017415:Ribonucleoprotein, U5 Small Nuclear; D029701:Saccharomyces cerevisiae Proteins; C088929:DIM1 protein, S cerevisiae; D008780:Methyltransferases