title: The nuclear envelope and transcriptional control.
abstract: Cells have evolved sophisticated multi-protein complexes that can regulate gene activity at various steps of the transcription process. Recent advances highlight the role of nuclear positioning in the control of gene expression and have put nuclear envelope components at centre stage. On the inner face of the nuclear envelope, active genes localize to nuclear-pore structures whereas silent chromatin localizes to non-pore sites. Nuclear-pore components seem to not only recruit the RNA-processing and RNA-export machinery, but contribute a level of regulation that might enhance gene expression in a heritable manner.
authors.affiliation: EMBL, Meyerhofstrasse 1, 69117 Heidelberg, Germany. Akhtar@embl.de
authors.forename: Asifa
authors.initials: A
authors.lastname: Akhtar
authors.forename: Susan M
authors.initials: SM
authors.lastname: Gasser
mesh_terms: D000818:Animals; D002843:Chromatin / Q000502:physiology; D004303:Dosage Compensation, Genetic; D004331:Drosophila melanogaster / Q000235:genetics; D044127:Epigenesis, Genetic; D005786:Gene Expression Regulation; D006570:Heterochromatin; D008957:Models, Genetic; D009685:Nuclear Envelope / Q000502:physiology*; D022022:Nuclear Pore / Q000502:physiology*; D012333:RNA, Messenger / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000235:genetics; D014158:Transcription, Genetic; D014960:X Chromosome
chemical_list: D002843:Chromatin; D006570:Heterochromatin; D012333:RNA, Messenger