Addition of difluoromethyl radicals to glycals: a new route to alpha-CF2-D-glycosides.
The synthesis of synthetically useful alpha-CF2-glycosides by radical addition of ethyl bromodifluoroacetate onto 2-benzyloxyglycals is described. The methodology provides an access to alpha-O-glycoside mimics and, potentially, to valuable alpha-O-glycoconjugate analogues.
Moreno
Benjamin
B
Laboratoire d'Hétérochimie Organique, UMR 6014 CNRS, IRCOF, INSA et Université de Rouen, 1 rue Tesnière, 76821 Mont Saint-Aignan Cedex, France.
Quehen
Cindy
C
Rose-Hélène
Maureen
M
Leclerc
Eric
E
Quirion
Jean-Charles
JC