title: Methotrexate treatment for type 1 (reversal) leprosy reactions.
abstract: Corticosteroids are the drugs of choice for treatment of type 1 leprosy reactions, but when these agents cannot be used because of their adverse effects, alternative treatments are needed. We report the first case, to our knowledge, of a type 1 leprosy reaction that was successfully treated with methotrexate in a patient intolerant to corticosteroids who had borderline lepromatous leprosy.
authors.affiliation: Tropical Medicine and Clinical Parasitology, Infectious Diseases Department, Ramón y Cajal Hospital, Madrid, Spain.
authors.forename: Guillermo
authors.initials: G
authors.lastname: Biosca
authors.forename: Sonia
authors.initials: S
authors.lastname: Casallo
authors.forename: Rogelio
authors.initials: R
authors.lastname: López-Vélez
mesh_terms: D004361:Drug Tolerance; D006801:Humans; D015439:Leprosy, Borderline / Q000188:drug therapy*; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use*; D008875:Middle Aged; D016896:Treatment Outcome
chemical_list: D008727:Methotrexate