title: Symptomatic and subclinical infection with rotavirus P[8]G9, rural Ecuador.
abstract: During the past decade, rotavirus genotype G9 has spread throughout the world, adding to and sometimes supplanting the common genotypes G1-G4. We report evidence of this spread in a population sample within rural Ecuador. A total of 1,656 stool samples were collected from both patients with diarrhea and from asymptomatic residents in 22 remote communities in northwestern Ecuador from August 2003 through February 2006. Rotavirus was detected in 23.4% of case-patients and 3.2% of controls. From these 136 rotavirus-positive samples, a subset of 47 were genotyped; 72% were of genotype G9, and 62% were genotype P[8]G9. As a comparison, 29 rotavirus-positive stool samples were collected from a hospital in Quito during March 2006 and genotyped; 86% were of genotype P[8]G9. Few countries have reported P[8]G9 rotavirus detection rates as high as those of the current study. This growing prevalence may require changes to current vaccination programs to include coverage for this genotype.
authors.affiliation: Universidad San Francisco de Quito, Quito, Ecuador.
authors.forename: Pablo
authors.initials: P
authors.lastname: Endara
authors.forename: Gabriel
authors.initials: G
authors.lastname: Trueba
authors.forename: Owen D
authors.initials: OD
authors.lastname: Solberg
authors.forename: Sarah J
authors.initials: SJ
authors.lastname: Bates
authors.forename: Karina
authors.initials: K
authors.lastname: Ponce
authors.forename: William
authors.initials: W
authors.lastname: Cevallos
authors.forename: Jelle
authors.initials: J
authors.lastname: Matthijnssens
authors.forename: Joseph N S
authors.initials: JN
authors.lastname: Eisenberg
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D004279:DNA, Viral / Q000032:analysis; D003967:Diarrhea / Q000453:epidemiology / Q000503:physiopathology / Q000821:virology; D004484:Ecuador / Q000453:epidemiology; D005243:Feces / Q000821:virology; D005838:Genotype; D006801:Humans; D007223:Infant; D008875:Middle Aged; D008969:Molecular Sequence Data; D010802:Phylogeny; D015995:Prevalence; D012401:Rotavirus / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification*; D012400:Rotavirus Infections / Q000453:epidemiology / Q000503:physiopathology / Q000821:virology; D012424:Rural Population; D017422:Sequence Analysis, DNA
chemical_list: D004279:DNA, Viral