title: Percutaneous transcatheter hepatic artery embolization for liver cysts in autosomal dominant polycystic kidney disease.
abstract: BACKGROUND
  We have achieved renal contraction therapy in patients with autosomal dominant polycystic kidney disease (ADPKD) by means of renal transcatheter arterial embolization (TAE) using intravascular coils, decreasing renal size and improving quality of life in almost all patients. We presently perform hepatic TAE in patients with intractable symptomatic polycystic liver.
  
  
  METHODS
  Uncontrolled trial.
  
  
  METHODS
  30 patients with ADPKD referred for arteriography to an academic medical center. 22 patients had kidney failure treated by means of dialysis.
  
  
  METHODS
  We embolized arteries supplying hepatic segments replaced by cysts that were associated with well-developed hepatic arteries, but obstructed intrahepatic portal veins.
  
  
  METHODS
  Various volumes before and after TAE were compared by using computed tomography and National Institutes of Health Image software in 30 patients with follow-up computed tomography 18 to 37 months after therapy.
  
  
  RESULTS
  Total liver volume and total intrahepatic cyst volume decreased from 7,882 +/- 2,916 and 6,677 +/- 2,978 to 6,041 +/- 2,282 and 4,625 +/- 2,299 cm(3), respectively (P < 0.0001 for both). Fractions of remaining (FR) total liver volume and FR of intrahepatic cyst volume were 78.8% +/- 17.6% and 70.4% +/- 20.9%, respectively. Hepatic parenchyma increased from 1,205 +/- 250 to 1,406 +/- 277 cm(3) (P = 0.0004). In 29 of 30 patients, both total liver volume and intrahepatic cyst volume decreased; in 1 patient, total liver volume increased from 5,755 to 7,069 cm(3), whereas cysts enlarged from 4,500 to 5,531 cm(3). No serious complications were experienced. In 24 patients, the post-TAE course was favorable. TAE failed to benefit 6 patients because of unrelated hepatic infection, peritonitis, hepatic failure, acute leukemia, or pelvic fracture.
  
  
  CONCLUSIONS
  Absence of a control group.
  
  
  CONCLUSIONS
  TAE may be an option for patients with ADPKD with symptomatic polycystic liver who are not candidates for surgical treatment.
authors.affiliation: Department of Radiology, Toranomon Hospital Kajigaya, Kawasaki, Kanagawa, Japan.
authors.forename: Ryoji
authors.initials: R
authors.lastname: Takei
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Ubara
authors.forename: Junichi
authors.initials: J
authors.lastname: Hoshino
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Higa
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Suwabe
authors.forename: Yoko
authors.initials: Y
authors.lastname: Sogawa
authors.forename: Kazufumi
authors.initials: K
authors.lastname: Nomura
authors.forename: Shohei
authors.initials: S
authors.lastname: Nakanishi
authors.forename: Naoki
authors.initials: N
authors.lastname: Sawa
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Katori
authors.forename: Fumi
authors.initials: F
authors.lastname: Takemoto
authors.forename: Shigeko
authors.initials: S
authors.lastname: Hara
authors.forename: Kenmei
authors.initials: K
authors.lastname: Takaichi
mesh_terms: D000328:Adult; D000368:Aged; D003404:Creatinine / Q000097:blood; D003560:Cysts / Q000097:blood / Q000000981:diagnostic imaging / Q000201:enzymology / Q000209:etiology / Q000473:pathology / Q000628:therapy*; D004621:Embolization, Therapeutic / Q000379:methods; D005260:Female; D006529:Hepatomegaly; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging; D008107:Liver Diseases / Q000097:blood / Q000000981:diagnostic imaging / Q000201:enzymology / Q000209:etiology / Q000473:pathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D016891:Polycystic Kidney, Autosomal Dominant / Q000150:complications* / Q000175:diagnosis; D015641:Radiography, Interventional; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D003404:Creatinine