title: The toll-like receptor 4 Asp299Gly variant and tuberculosis susceptibility in HIV-infected patients in Tanzania.
abstract: Toll-like receptor 4 (TLR4) plays an important role in the pattern recognition of Mycobacterium tuberculosis, and polymorphisms in the TLR4 gene influence the function of the receptor. We therefore investigated in a cohort of HIV-infected Tanzanian patients whether the Asp299Gly TLR4 polymorphism is associated with the development of active tuberculosis. We found a greater risk of developing active tuberculosis as well as a reduction in CD4 T-cell counts in patients with the Asp299Gly TLR4 polymorphism.
authors.affiliation: Department of Medicine, Radboud University Nijmegen Medical Center, Nijmegen, the Netherlands.
authors.forename: Bart
authors.initials: B
authors.lastname: Ferwerda
authors.forename: Gibson S
authors.initials: GS
authors.lastname: Kibiki
authors.forename: Mihai G
authors.initials: MG
authors.lastname: Netea
authors.forename: Wil M V
authors.initials: WM
authors.lastname: Dolmans
authors.forename: Andre J
authors.initials: AJ
authors.lastname: van der Ven
mesh_terms: D018791:CD4 Lymphocyte Count; D015331:Cohort Studies; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics; D015658:HIV Infections / Q000150:complications / Q000453:epidemiology / Q000235:genetics*; D006801:Humans; D011110:Polymorphism, Genetic / Q000235:genetics*; D013636:Tanzania / Q000453:epidemiology; D051197:Toll-Like Receptor 4 / Q000235:genetics*; D014397:Tuberculosis, Pulmonary / Q000150:complications / Q000453:epidemiology / Q000235:genetics*
chemical_list: C495345:TLR4 protein, human; D051197:Toll-Like Receptor 4