title: Nonfasting low-density lipoprotein testing: utility for cholesterol screening in pediatric primary care.
abstract: This prospective study assessed the clinical application of a nonfasting low-density lipoprotein cholesterol measure in a pediatric primary care population. A homogenous direct low-density lipoprotein cholesterol assay was tested in healthy children, aged 4 to 12 years, at risk for hyperlipidemia, as defined by American Academy of Pediatrics, and including patients with incomplete family histories. This nonfasting homogeneous assay was comparable to modified beta quantification, the gold standard reference method of measuring low-density lipoprotein cholesterol, and the current recommended screening method, total cholesterol. Results from the study suggest that this nonfasting assay can provide more direct low-density lipoprotein cholesterol measurements for healthy children, with improved clinical utility and greater overall patient convenience in testing for important cholesterol abnormalities.
authors.affiliation: Department of Cardiology, Children's Hospital Boston, Boston, MA 02115, USA. sarah.deferranti@cardio.chboston.org
authors.forename: Sarah
authors.initials: S
authors.lastname: de Ferranti
authors.forename: David
authors.initials: D
authors.lastname: Shapiro
authors.forename: Robert
authors.initials: R
authors.lastname: Markowitz
authors.forename: Ellis
authors.initials: E
authors.lastname: Neufeld
authors.forename: Nader
authors.initials: N
authors.lastname: Rifai
authors.forename: Henry
authors.initials: H
authors.lastname: Bernstein
mesh_terms: D002648:Child; D002675:Child, Preschool; D008078:Cholesterol, LDL / Q000097:blood*; D005215:Fasting; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000175:diagnosis*; D008403:Mass Screening / Q000379:methods*; D010372:Pediatrics; D011320:Primary Health Care; D011446:Prospective Studies
chemical_list: D008078:Cholesterol, LDL