Outpatient allografting using non-myeloablative conditioning: the Mexican experience.
A group of 132 patients with both malignant and nonmalignant conditions was allografted using the 'Mexican' method of non-ablative conditioning. The conditioning was delivered on an outpatient basis and the procedure was planned to be conducted on outpatients in all cases. While 103 patients (78%) were able to complete the procedure totally as outpatients, 29 (22%) were hospitalized because of fever, mucositis or acute graft-versus-host disease. In a multivariate analysis, although differences were not statistically significant, it was found that the patients who were allografted as outpatients had higher levels of hemoglobin (12 versus 11.8 g/dl), higher platelet counts (248 versus 191 x 10(9)/l), lower white blood cell counts (11.7 versus 12.4 x 10(9)/l), higher Karnofsky scale scores (100 versus 90%) and lower creatinine levels (0.9 versus 0.93 mg/dl). A total of 86% of the patients with normal values for these variables could be allografted as outpatients, whereas only 67% of those with abnormal values completed the entire procedure as outpatients. It is concluded that allografting can be accomplished totally on an outpatient basis using the 'Mexican' reduced intensity-conditioning regimen.
Cantú-Rodríguez
O G
OG
Servicio de Hematología, Hospital Universitario Dr José Eleuterio González, Universidad Autónoma de Nuevo León, CP 64610 Monterrey, Nuevo León, México.
Jaime-Pérez
J C
JC
Gutiérrez-Aguirre
C H
CH
González-Llano
O
O
Mancías-Guerra
C
C
Tarín-Arzaga
L C
LC
Ruiz-Delgado
G J
GJ
Sandoval-Villa
C C
CC
Marfil-Rivera
J
J
Morales-Toquero
A
A
Ruiz-Argüelles
G J
GJ
Gómez-Almaguer
D
D
D000293:Adolescent; D000328:Adult; D000553:Ambulatory Care; D002648:Child; D005260:Female; D006402:Hematologic Diseases / Q000401:mortality / Q000628:therapy; D019337:Hematologic Neoplasms / Q000401:mortality / Q000628:therapy; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects / Q000379:methods*; D006760:Hospitalization; D006801:Humans; D008297:Male; D008800:Mexico; D008875:Middle Aged; D012449:Safety; D015996:Survival Rate; D019172:Transplantation Conditioning / Q000009:adverse effects / Q000379:methods*; D014184:Transplantation, Homologous