Intra-amygdala all-trans retinoic acid inhibits amygdala-kindled seizures in rats.
Amygdala plays an important role in induction and control of limbic seizures. There is a network of gap junctional communications in basolateral amygdala (BLA) as well. We compared the effect of intra-BLA infusion of the typical gap junction (GJ) blocker carbenoxolone (CBX), with the effect of putative GJ blocker all-trans retinoic acid (ATRA), on the afterdischarge (AD) recorded from BLA in amygdala-kindled rats. Both CBX and ATRA showed a rapid anti-seizure effect. Conversely, intra-BLA infusion of the known GJ opener, trimethylamine (TMA), enhanced seizure susceptibility by prolonging the duration of AD and generalized behavioral seizures. ATRA administered intra-BLA prevented the proconvulsant effect of TMA. The reduction of gap junctional conductance might be involved in the observed anticonvulsant effect of ATRA.
Sayyah
Mohammad
M
Department of Physiology and Pharmacology, Institute Pasteur of Iran, Pasteur Avenue, Tehran 1316943551, Iran. sayyahm2@pasteur.ac.ir
Rezaie
Mohsen
M
Haghighi
Saeid
S
Amanzadeh
Amir
A
D000679:Amygdala / Q000502:physiology*; D000818:Animals; D002229:Carbenoxolone / Q000008:administration & dosage / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004558:Electric Stimulation; D017629:Gap Junctions / Q000187:drug effects; D007696:Kindling, Neurologic / Q000187:drug effects / Q000502:physiology*; D008297:Male; D008744:Methylamines / Q000008:administration & dosage / Q000494:pharmacology; D008845:Microinjections; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000188:drug therapy* / Q000523:psychology; D013238:Stereotaxic Techniques; D014212:Tretinoin / Q000008:administration & dosage / Q000627:therapeutic use*
D008744:Methylamines; D014212:Tretinoin; C023336:trimethylamine; D002229:Carbenoxolone