title: Angioedema of the airway: an unusual case.
abstract: We report a case of angioedema caused by angiotensin-converting enzyme inhibitor and topical lignocaine spray, administered during nasendoscopy. Angioedema induced by angiotensin-converting enzyme inhibitors is a rare but well known entity. Allergy to topical lignocaine has been acknowledged as a rare phenomenon when used for dental surgery and for skin anaesthesia, but it has not previously been reported after topical administration prior to nasendoscopy. In the reported case, our patient was unfortunate enough to be allergic to both lisinopril and lignocaine. The result was life-threatening airway obstruction, and the continued use of lignocaine spray sustained the laryngeal oedema. We advise that patients are asked about any and every allergy--specifically, any previous problems with dental procedures--before administration of local anaesthetic spray to the upper aerodigestive tract.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Immunology, Manchester Royal Infirmary, UK. ajroper@doctors.org.uk
authors.forename: A J
authors.initials: AJ
authors.lastname: Roper
authors.forename: A
authors.initials: A
authors.lastname: Farragher
authors.forename: J J
authors.initials: JJ
authors.lastname: Homer
authors.forename: M
authors.initials: M
authors.lastname: Helbert
mesh_terms: D000287:Administration, Topical; D000368:Aged; D000402:Airway Obstruction / Q000139:chemically induced*; D000779:Anesthetics, Local / Q000009:adverse effects*; D000799:Angioedema / Q000139:chemically induced*; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects*; D006801:Humans; D008012:Lidocaine / Q000009:adverse effects; D017706:Lisinopril / Q000009:adverse effects; D008297:Male
chemical_list: D000779:Anesthetics, Local; D000806:Angiotensin-Converting Enzyme Inhibitors; D008012:Lidocaine; D017706:Lisinopril