title: Randomized comparative study of diamond-like carbon coated stainless steel stent versus uncoated stent implantation in patients with coronary artery disease.
abstract: OBJECTIVE
  To compare restenosis and major cardiac event rates at one and six months after DLC-coated stent implantation with those of uncoated stents.
  
  
  METHODS
  Randomized, prospective, comparative study of 180 patients with coronary insufficiency undergoing DLC coated stent (Phytis) or uncoated stent (Penta) implantation, from January, 2003 to July, 2004. Inclusion criteria were: de novo lesion with >50% diameter stenosis in a coronary artery with reference diameter > or = 2.5 mm and < or = 4 mm, and length < 20 mm. Exclusion criteria were: left main coronary artery and bifurcation lesions, chronic total occlusion, and in-stent restenosis.
  
  
  RESULTS
  Clinical and angiographic baseline characteristics of the groups were similar. Procedural success was achieved in 98.9% of the patients in both groups. One cardiac death occurred in each group during hospitalization. Reference diameter and acute gain were greater in the Penta group (3.21 +/- 0.37 mm vs. 3.34 +/- 0.8 mm, p=0.02 and 2.3 +/- 0.5 vs. 2.49 +/- 0.5, p=0.009, respectively). Angiographic follow-up at six months showed similar rates of restenosis (24.3% vs. 21.8%, p=0.84) and of major cardiac events (16.8% vs. 17.5%, p=1).
  
  
  CONCLUSIONS
  DLC coated stents did not provide better outcomes in relation to uncoated stents.
authors.affiliation: Hospital Stella Maris, São Paulo, SP, Brazil. gcxm@cardiol.br
authors.forename: George César Ximenes
authors.initials: GC
authors.lastname: Meireles
authors.forename: Luciano Mauricio
authors.initials: LM
authors.lastname: de Abreu
authors.forename: Antonio Artur da Cruz
authors.initials: AA
authors.lastname: Forte
authors.forename: Marcos Kiyoshi
authors.initials: MK
authors.lastname: Sumita
authors.forename: Jorge Hideki
authors.initials: JH
authors.lastname: Sumita
authors.forename: Jose Del Carmen Solano
authors.initials: Jdel C
authors.lastname: Aliaga
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D015906:Angioplasty, Balloon, Coronary; D002244:Carbon; D020099:Coated Materials, Biocompatible; D003324:Coronary Artery Disease / Q000628:therapy*; D023903:Coronary Restenosis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013193:Stainless Steel; D015607:Stents; D016896:Treatment Outcome
chemical_list: D020099:Coated Materials, Biocompatible; D013193:Stainless Steel; D002244:Carbon