title: [The reference values of glycemic parameters for continuous glucose monitoring and its clinical application].
abstract: OBJECTIVE
  To establish reference values of glycemic parameters for continuous glucose monitoring in Chinese.
  
  
  METHODS
  Forty-eight individuals with normal glucose regulation were observed with continuous glucose monitoring system (CGMS) for 3 days. Indexes in CGMS were analyzed, including mean level of 24 h blood glucose (BG) values (24 h MBG) and its standard deviation (SDBG), percentage of time above 7.8 mmol/L or below 3.9 mmol/L, area under the curve (AUC) of BG above 5.6 mmol/L, the largest amplitude of glycemic excursions (LAGE), mean amplitude of glycemic excursions (MAGE) and absolute means of daily differences (MODD).
  
  
  RESULTS
  (1) The upper limits of indexes for continuous glucose monitoring were as follows: 6.5 mmol/L for 24 h MBG, 6.0 mmol/L, 6.3 mmol/L and 6.0 mmol/L for mean BG levels 1 h before breakfast, lunch and dinner respectively, 7.0 mmol/L, 6.7 mmol/L and 7.0 mmol/L for mean BG levels 3 h after breakfast, lunch and dinner respectively, 1.4 mmol/L for SDBG, 5.7 mmol/L for LAGE, 3.4 mmol/L for MAGE and 1.4 mmol/L for MODD. The percentage of time over 7.8 mmol/L was less than 9%, while the percentage of time below 3.9 mmol/L was less than 20%. The AUC of BG above 5.6 mmol/L was less than 0.9 d x mmol x L(-1). There was no statistical difference among sex subgroups (P > 0.05). (2) The correlations of 24h MBG with MAGE, MODD and SDBG were not significant (P > 0.05). MAGE was positively correlated with SDBG (r = 0.93, P < 0.01).
  
  
  CONCLUSIONS
  The reference values of glycemic parameters for continuous glucose monitoring are initially established and can be used as a temporary reference for clinical practice in Chinese. The CGMS profile can reflect the overall BG control and the feature of glycemic excursions in detail.
authors.affiliation: Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Department of Endocrinology and Metabolism, The Sixth People's Hospital, Affiliated to Jiaotong University, Shanghai 200233, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Zhou
authors.forename: Wei-ping
authors.initials: WP
authors.lastname: Jia
authors.forename: Ming
authors.initials: M
authors.lastname: Yu
authors.forename: Hao-yong
authors.initials: HY
authors.lastname: Yu
authors.forename: Yu-qian
authors.initials: YQ
authors.lastname: Bao
authors.forename: Xiao-jing
authors.initials: XJ
authors.lastname: Ma
authors.forename: Wei
authors.initials: W
authors.lastname: Lu
authors.forename: Cheng
authors.initials: C
authors.lastname: Hu
authors.forename: Kun-san
authors.initials: KS
authors.lastname: Xiang
mesh_terms: D000328:Adult; D019540:Area Under Curve; D001786:Blood Glucose / Q000378:metabolism*; D002681:China; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic / Q000592:standards*; D012016:Reference Values
chemical_list: D001786:Blood Glucose