title: Perforating neutrophilic and granulomatous dermatitis of the newborn--a clue to immunodeficiency.
abstract: We report two newborns with a widespread cutaneous eruption consisting of discrete papules which evolved into vesicles, pustules, crusts, and ulcers. These healed over a 2-week period with scarring. Histopathology showed three main features--histiocytic granulomas, neutrophilic infiltration, and transepidermal elimination of degenerated collagen and debris through hair follicles. Both patients had congenital immunodeficiency. This skin condition of the newborn, with distinct clinical and histopathologic features, is a manifestation of immunodeficiency that has not been previously described.
authors.affiliation: Department of Dermatology, Hospital del Niño Jesús, Madrid, Spain. atorrelo@aedv.es
authors.forename: Antonio
authors.initials: A
authors.lastname: Torrelo
authors.forename: Angel
authors.initials: A
authors.lastname: Vera
authors.forename: Mar
authors.initials: M
authors.lastname: Portugués
authors.forename: Inmaculada
authors.initials: I
authors.lastname: de Prada
authors.forename: Andrés
authors.initials: A
authors.lastname: Sanz
authors.forename: Isabel
authors.initials: I
authors.lastname: Colmenero
authors.forename: Ander
authors.initials: A
authors.lastname: Zulaica
authors.forename: Raúl
authors.initials: R
authors.lastname: de Lucas
authors.forename: Javier
authors.initials: J
authors.lastname: Fraga
authors.forename: Javier
authors.initials: J
authors.lastname: Pedraz
authors.forename: Sindo
authors.initials: S
authors.lastname: Fontán
authors.forename: Antonio
authors.initials: A
authors.lastname: Zambrano
mesh_terms: D000361:Agammaglobulinemia / Q000150:complications*; D002097:C-Reactive Protein / Q000032:analysis; D003872:Dermatitis / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D005260:Female; D015726:Giant Cells / Q000473:pathology; D006099:Granuloma / Q000276:immunology* / Q000473:pathology; D006644:Histiocytes / Q000473:pathology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009077:Mucins / Q000378:metabolism; D020556:Neutrophil Infiltration; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D009077:Mucins; D002097:C-Reactive Protein