Esophageal involvement in microscopic polyangiitis: a case report and review of literature.
A 72-year-old man with cough and sputum showed esophageal wall thickening and pneumonia in chest computed tomography (CT) scan. Following endoscopy, we diagnosed reflux esophagitis and subscribed proton pump inhibitor. The esophageal lesion, however, was intractable. We diagnosed microscopic polyangiitis (MPA) because of vasculitis symptoms, cytoplasmic antineutrophil cytoplasmic antibodies (cANCA) in blood and no granulomatous change in the esophagus. We adopted pulse therapy of cyclophosphamide and oral prednisolone; the symptoms and esophageal lesion were markedly improved. We concluded that the esophageal lesion was an aspect of MPA. To our knowledge, this is the first report of esophageal involvement in MPA.
Matsumoto
Masataka
M
Department of Gastroenterology & Hepatology, Kitano Hospital, Osaka, Japan. ma-matsumoto@kitano-hp.or.jp
Nakamura
Takefumi
T
Ohashi
Tsuyoshi
T
Okuno
Tomoko
T
Takasu
Kosho
K
Hoshino
Shouichi
S
Sugiura
Yasushi
Y
Ueshima
Dan
D
Suzuki
Naoyuki
N
Uose
Suguru
S
Nada
Takayuki
T
Kawaguchi
Kiyotaka
K
D000368:Aged; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood*; D003520:Cyclophosphamide / Q000627:therapeutic use; D003937:Diagnosis, Differential; D004941:Esophagitis / Q000209:etiology* / Q000473:pathology* / Q000628:therapy; D014890:Granulomatosis with Polyangiitis / Q000175:diagnosis / Q000473:pathology*; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D010951:Plasma Exchange; D010488:Polyarteritis Nodosa / Q000150:complications* / Q000473:pathology* / Q000628:therapy; D011239:Prednisolone / Q000627:therapeutic use
D019268:Antibodies, Antineutrophil Cytoplasmic; D016756:Immunoglobulins, Intravenous; D007166:Immunosuppressive Agents; D003520:Cyclophosphamide; D011239:Prednisolone