C-reactive protein: a pentraxin with anti-acetylcholine activity.
Purified C-reactive protein (CRP) diminished effects of acetylcholine (ACh) on the vascular tone and the heart rate of rats in vivo. In vitro CRP inhibited breakdown of ACh by acetylcholinesterase (AChE) while did not interact with AChE itself. CRP appears to bind ACh. CRP did not modify the cardiovascular effects of adenosine, another vasorelaxant. The data suggest that there is a new line of cross-talk between the inflammation and cholinergic regulation with CRP acting on endothelium via the ACh-dependent pathway.
Nazarov
Peter G
PG
Laboratory of General Immunology, Institute of Experimental Medicine, 12 Acad. Pavlov Street, St. Petersburg, 197376, Russia. pnazarov@pn4093.spb.edu
Krylova
Irina B
IB
Evdokimova
Natalia R
NR
Nezhinskaya
Galina I
GI
Butyugov
Alexander A
AA
D000109:Acetylcholine / Q000037:antagonists & inhibitors / Q000378:metabolism / Q000494:pharmacology*; D000110:Acetylcholinesterase / Q000378:metabolism; D000241:Adenosine / Q000494:pharmacology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002097:C-Reactive Protein / Q000494:pharmacology*; D004347:Drug Interactions; D006339:Heart Rate / Q000187:drug effects; D006868:Hydrolysis / Q000187:drug effects; D008297:Male; D009419:Nerve Tissue Proteins / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D014665:Vasodilator Agents / Q000494:pharmacology; D000099153:Pentraxins
D000109:Acetylcholine; D000110:Acetylcholinesterase; D000241:Adenosine; D002097:C-Reactive Protein; D009419:Nerve Tissue Proteins; D014665:Vasodilator Agents; D000099153:Pentraxins