title: Revisions to the staging and classification of mycosis fungoides and Sezary syndrome: a proposal of the International Society for Cutaneous Lymphomas (ISCL) and the cutaneous lymphoma task force of the European Organization of Research and Treatment of Cancer (EORTC).
abstract: The ISCL/EORTC recommends revisions to the Mycosis Fungoides Cooperative Group classification and staging system for cutaneous T-cell lymphoma (CTCL). These revisions are made to incorporate advances related to tumor cell biology and diagnostic techniques as pertains to mycosis fungoides (MF) and Sézary syndrome (SS) since the 1979 publication of the original guidelines, to clarify certain variables that currently impede effective interinstitution and interinvestigator communication and/or the development of standardized clinical trials in MF and SS, and to provide a platform for tracking other variables of potential prognostic significance. Moreover, given the difference in prognosis and clinical characteristics of the non-MF/non-SS subtypes of cutaneous lymphoma, this revision pertains specifically to MF and SS. The evidence supporting the revisions is discussed as well as recommendations for evaluation and staging procedures based on these revisions.
authors.affiliation: Department of Medicine, Divisions of Dermatology and Oncology, Duke University Medical Center, Durham, NC 27516, USA. olsen001@mc.duke.edu
authors.forename: Elise
authors.initials: E
authors.lastname: Olsen
authors.forename: Eric
authors.initials: E
authors.lastname: Vonderheid
authors.forename: Nicola
authors.initials: N
authors.lastname: Pimpinelli
authors.forename: Rein
authors.initials: R
authors.lastname: Willemze
authors.forename: Youn
authors.initials: Y
authors.lastname: Kim
authors.forename: Robert
authors.initials: R
authors.lastname: Knobler
authors.forename: Herschel
authors.initials: H
authors.lastname: Zackheim
authors.forename: Madeleine
authors.initials: M
authors.lastname: Duvic
authors.forename: Teresa
authors.initials: T
authors.lastname: Estrach
authors.forename: Stanford
authors.initials: S
authors.lastname: Lamberg
authors.forename: Gary
authors.initials: G
authors.lastname: Wood
authors.forename: Reinhard
authors.initials: R
authors.lastname: Dummer
authors.forename: Annamari
authors.initials: A
authors.lastname: Ranki
authors.forename: Gunter
authors.initials: G
authors.lastname: Burg
authors.forename: Peter
authors.initials: P
authors.lastname: Heald
authors.forename: Mark
authors.initials: M
authors.lastname: Pittelkow
authors.forename: Maria-Grazia
authors.initials: MG
authors.lastname: Bernengo
authors.forename: Wolfram
authors.initials: W
authors.lastname: Sterry
authors.forename: Liliane
authors.initials: L
authors.lastname: Laroche
authors.forename: Franz
authors.initials: F
authors.lastname: Trautinger
authors.forename: Sean
authors.initials: S
authors.lastname: Whittaker
mesh_terms: D005060:Europe; D006801:Humans; D009182:Mycosis Fungoides / Q000145:classification* / Q000473:pathology; D009367:Neoplasm Staging; D012751:Sezary Syndrome / Q000145:classification* / Q000473:pathology; D012878:Skin Neoplasms / Q000145:classification* / Q000473:pathology*; D012955:Societies, Medical