[Effects of Tongxinluo capsule on atherosclerosis obliterans in iliofemoral artery of rabbits].
OBJECTIVE
To explore the effects of Tongxinluo capsule (TXL) on the atherosclerosis obliterans (ASO) in iliofemoral artery of rabbits.


METHODS
Rabbits were randomly divided into 7 groups: sham, model, TXL (0.8, 0.4, 0.2 g x kg(-1)), Tongsaimai tablet (0.8 g x kg(-1)) and Laishike (0.002 g x kg(-1)). The animal model of ASO was established with a combined method of mechanical trauma, immunologic injury and high fat fodder feeding. Rabbits were administrated the drugs 8 weeks after surgery. The levels of TC, TG, HDL-C and LDL-C in serum were determined at the time points below: pre-experiment (0 week), pre-drug administration (8 weeks post-surgery), 4 weeks after drug administration (12 weeks post-surgery), 8 weeks after drug administration (16 weeks post-surgery), 12 weeks after drug administration (20 weeks post-surgery). Meanwhile, the behavioral study was performed, the distal skin temperature of the injured hind limb detected. The histopathological changes in iliofemoral artery were examined after opacification.


RESULTS
The levels of TC, TG, LDL-C, VLDL-C and TC/HDL-C were decreased significantly in serum of ASO rabbits. The severity of lameness in the injured hind limb was improved. The distal skin temperature was increased. The thickness and the ratio of intima area of the iliofemoral artery of the injured hind limb were decreased, while the stenosis extent was improved.


CONCLUSIONS
TXL might be beneficial to modulate blood lipid, as well as the prevention and treatment for ASO.
Lin
Cheng-Ren
CR
Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China. chengren1230@sina.com
Ma
Xue-Ying
XY
Wang
Min
M
Zhuang
Bai-Xi
BX
Liu
Jian-Xun
JX
D000818:Animals; D001162:Arteriosclerosis Obliterans / Q000097:blood / Q000473:pathology* / Q000517:prevention & control; D001181:Arthropods / Q000737:chemistry; D001522:Behavior, Animal / Q000187:drug effects; D002214:Capsules; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D005263:Femoral Artery / Q000187:drug effects / Q000473:pathology; D007083:Iliac Artery / Q000187:drug effects / Q000473:pathology; D008297:Male; D008419:Materia Medica / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry; D011817:Rabbits; D011897:Random Allocation; D014280:Triglycerides / Q000097:blood; D017539:Tunica Intima / Q000187:drug effects* / Q000473:pathology
D002214:Capsules; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D008419:Materia Medica; D014280:Triglycerides; C513941:tongxinluo; D002784:Cholesterol