title: [Functional renal investigation in Fabry disease].
abstract: Progressive decline in kidney function is a cardinal manifestation of Fbry disease. Proteinuria is usually the earliest biological marker of renal involvement. Renoprotection should associate both effective Enzyme Replocement Therapy (ERT) and non-specific anti-proteinuric therapy as recommended for all chronic kidney diseases. ERT has demonstrated high efficiency in the early clearing of globotriaosylceromide deposits, however the functional protecting effect on GFR decrease remains to be validated, especially in patients with CKD stage 3 or higher Estimation of GFR should be very cautious using creatinine based formulas, leading to measure GFR whenever possible in order to characterize the progression of CKD in Fabry patients.
authors.affiliation: Département de Physiologie, Hôpital Européen Georges-Pompidou, Assistance Publique-Hôpitaux de Paris, INSERM U872 et Université Paris Descartes, Paris (75), France. marc.froissart@egp.aphp.fr
authors.forename: Marc
authors.initials: M
authors.lastname: Froissart
authors.forename: Karelle
authors.initials: K
authors.lastname: Benistan
authors.forename: Dominique P
authors.initials: DP
authors.lastname: Germain
mesh_terms: D000795:Fabry Disease / Q000150:complications*; D006801:Humans; D007674:Kidney Diseases / Q000175:diagnosis / Q000209:etiology* / Q000517:prevention & control*; D011507:Proteinuria / Q000209:etiology / Q000517:prevention & control; D000519:alpha-Galactosidase / Q000627:therapeutic use
chemical_list: D000519:alpha-Galactosidase