Cutting edge: Transitional T3 B cells do not give rise to mature B cells, have undergone selection, and are reduced in murine lupus.
As the immediate precursors to mature follicular B cells in splenic development, immature transitional cells are an essential component for understanding late B cell differentiation. It has been shown that T2 cells can give rise to mature B cells; however, whether T3 B cells represent a normal stage of B cell development, which has been widely assumed, has not been fully resolved. In this study, we demonstrate both in vitro and in vivo that T3 B cells do not give rise to mature B cells and are instead selected away from the T1-->T2-->mature B cell developmental pathway and are hyporesponsive to stimulation through the BCR. Significantly reduced numbers of T3 B cells in young lupus-prone mice further suggest that the specificity of this subset holds clues to understanding autoimmunity.
Teague
Brittany N
BN
Arthritis and Immunology Research Program, Oklahoma Medical Research Foundation, 815 North East 13th Street, Oklahoma City, OK 73104, USA.
Pan
Yujun
Y
Mudd
Philip A
PA
Nakken
Britt
B
Zhang
Qingzhao
Q
Szodoray
Peter
P
Kim-Howard
Xana
X
Wilson
Patrick C
PC
Farris
A Darise
AD
D000818:Animals; D053264:B-Cell Activating Factor / Q000378:metabolism*; D016175:B-Lymphocyte Subsets / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology*; D020013:Calcium Signaling; D004195:Disease Models, Animal; D005260:Female; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D008213:Lymphocyte Activation; D018655:Lymphocyte Count; D051379:Mice; D008810:Mice, Inbred C57BL; D011947:Receptors, Antigen, B-Cell / Q000819:agonists / Q000378:metabolism*; D013154:Spleen / Q000276:immunology*
D053264:B-Cell Activating Factor; D011947:Receptors, Antigen, B-Cell; C505720:Tnfsf13b protein, mouse