Atherosclerosis in the back yard.
The phenomenon of neovascularization in atherosclerosis has been widely recognized through "the eyes of novel imaging techniques" in recent years. Oxidative stress, inflammation, and hypoxia have been implied as the underlying mechanisms. The pathophysiologic consequences and therapeutic implications of this neovascularization process for atherosclerosis have, however, remained challenging and controversial. In the current focus issue of the Journal, 4 articles and this commentary are devoted to this topic.
Herrmann
Joerg
J
Department of Internal Medicine, Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota 55905, USA.
Lerman
Amir
A
D020533:Angiogenesis Inhibitors / Q000627:therapeutic use; D003324:Coronary Artery Disease / Q000188:drug therapy* / Q000473:pathology*; D003331:Coronary Vessels / Q000473:pathology; D006470:Hemorrhage / Q000473:pathology; D006801:Humans; D009389:Neovascularization, Pathologic / Q000188:drug therapy* / Q000473:pathology*
D020533:Angiogenesis Inhibitors