[Effects of 2-n-nonyl-1,3-dioxolane as an enhanceron transdermal absorption of Salvia miltiorrhiza gel].
OBJECTIVE
To choose the most suitable concentration of 2-n-nonyl-1,3-dioxolane as a penetration enhancer in tanshinone gel preparation.


METHODS
In vitro, transdermal absorption was studied using improved Frans equipment and rats skin. Tanshinone II A was tested by HPLC.


RESULTS
The 4.0% concentration of 2-n-nonyl-1,3-dioxolane enhanced the transdermal absorption significantly in the preparation.


CONCLUSIONS
2-n-nonyl-1,3-dioxolane was a new effective permeaton enhancer.
Sha
Mei
M
Fujian College of Traditional Chinese Medicine, Fuzhou 350108, China. orgchemsha@sina.com
Yin
Li-Fang
LF
Xu
Wei
W
Chen
Yu-Zhi
YZ
D045784:Abietanes; D000279:Administration, Cutaneous; D000818:Animals; D004148:Dioxolanes / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000302:isolation & purification / Q000493:pharmacokinetics*; D005260:Female; D005782:Gels; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D010616:Phenanthrenes / Q000032:analysis; D015203:Reproducibility of Results; D027561:Salvia miltiorrhiza / Q000737:chemistry*; D012867:Skin / Q000187:drug effects / Q000378:metabolism; D012869:Skin Absorption / Q000187:drug effects*
D045784:Abietanes; D004148:Dioxolanes; D004365:Drugs, Chinese Herbal; D005782:Gels; D010616:Phenanthrenes; C021751:tanshinone; C111109:2-n-nonyl-1,3-dioxolane