Evaluation of relationship between clinical and colonoscopic features in patients with active ulcerative colitis.
OBJECTIVE
To develop a system to score disease activity based on clinical manifestations in patients with active ulcerative colitis and to assess the relationship of this score with endoscopic disease severity as assessed by colonoscopy.


METHODS
In a pilot study of 43 patients, nine clinical variables were examined by univariate analysis. Six factors that correlated with disease severity included age, well-being, defecation frequency, bloody stool, extraintestinal manifestations (Ext) and hemoglobin (Hb). Multivariate analysis resulted in the generation of a new activity index for the prediction of disease severity. Validation of this index was performed on 88 patients with definite diagnosis of ulcerative coli-tis based on previous histological examination.


RESULTS
The activity index is derived as follows: (18 x bloody stool) + (20 x defecation frequency) + (5 x Ext) + (15 x Hb) - (well-being x 17) + (age x 2) + 158. Values below 280, between 280 and 310 and above 310 corresponded to mild, moderate and severe disease, respectively. The model classified disease severity correctly in 71% of cases.


CONCLUSIONS
This activity index may be useful for noninvasive evaluation of disease severity in patients with ulcerative colitis.
Mirpour
Sahar
S
Department of Gasteroenterology, Azad University of Medical Sciences, North Karegar St, 14114, Medical Sciences/University of Tehran, Tehran, Iran. mirpour@razi.tums.ac.ir
Rabie
Rouzbeh
R
Mirpour
Koorosh
K
Gholamrezanezhad
Ali
A
D000293:Adolescent; D000328:Adult; D000368:Aged; D003093:Colitis, Ulcerative / Q000175:diagnosis* / Q000473:pathology; D003113:Colonoscopy; D005260:Female; D006801:Humans; D007194:India; D007413:Intestinal Mucosa / Q000473:pathology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012720:Severity of Illness Index