title: BK virus associated meningoencephalitis in an AIDS patient treated with HAART.
abstract: A severely immune-suppressed AIDS patient was suspected of suffering from BK virus (BKV) meningoencephalitis, after being studied for common causes of neurological complications of co-infectious origin. Polymerase chain reaction (PCR) and sequence analysis of cerebrospinal fluid and brain samples, confirmed the presence of BKV. His clinical condition improved along with the regression of brain lesions, after modifications on his antiretroviral regime. Five months after discharge, the patient was readmitted because of frequent headaches, and a marked inflammatory reaction was evidenced by a new magnetic resonance imaging (MRI). The symptoms paralleled a rising CD4+ lymphocyte count, and immune reconstitution syndrome was suspected. This is the first non-postmortem report of BKV meningoencephalitis in an AIDS patient, showing clinical and radiographic improvement solely under HAART.
authors.affiliation: Department of Infectious Diseases, Emilio Ribas Institute of Infectious Diseases, São Paulo, Brazil. josevibe@gmail.com
authors.forename: José E
authors.initials: JE
authors.lastname: Vidal
authors.forename: Maria C
authors.initials: MC
authors.lastname: Fink
authors.forename: Filiberto
authors.initials: F
authors.lastname: Cedeno-Laurent
authors.forename: Serena
authors.initials: S
authors.lastname: Delbue
authors.forename: Pasquale
authors.initials: P
authors.lastname: Ferrante
authors.forename: Rafi F
authors.initials: RF
authors.lastname: Dauar
authors.forename: Francisco Bonasser
authors.initials: FB
authors.lastname: Filho
authors.forename: Roberta Schiavon
authors.initials: RS
authors.lastname: Nogueira
authors.forename: Eduardo E
authors.initials: EE
authors.lastname: Calore
authors.forename: Claudio S
authors.initials: CS
authors.lastname: Pannuti
authors.forename: J Roberto
authors.initials: JR
authors.lastname: Trujillo
authors.forename: Augusto C Penalva
authors.initials: AC
authors.lastname: de Oliveira