title: Surgical treatment of peri-implantitis using a bone substitute with or without a resorbable membrane: a prospective cohort study.
abstract: OBJECTIVE
  The aim of this prospective cohort study was to compare two regenerative surgical treatment modalities for peri-implantitis.
  
  
  METHODS
  Thirty-six patients having a minimum of one osseointegrated implant, with a progressive loss of bone amounting to > or =3 threads (1.8 mm) following the first year of healing, combined with bleeding and/or pus on probing, were involved in this study. The patients were assigned to two different treatment strategies. After surgical exposure of the defect, granulomatous tissue was removed and the infected implant surface was treated using 3% hydrogen peroxide. The bone defects were filled with a bone substitute (Algipore). In 17 patients (Group 1), a resorbable membrane (Osseoquest) was placed over the grafted defect before suturing. In 19 patients (Group 2), the graft was used alone.
  
  
  RESULTS
  One-year follow-up demonstrated clinical and radiographic improvements. Probing depths were reduced by 2.9 mm in Group 1 and by 3.4 mm in Group 2. Defect fill amounted to 1.5 and 1.4 mm, respectively. There was no significant difference between the groups.
  
  
  CONCLUSIONS
  It is possible to treat peri-implant defects with a bone substitute, with or without a resorbable membrane.
authors.affiliation: Department of Health Sciences, Kristianstad University, Kristianstad, Sweden.
authors.forename: Ann-Marie
authors.initials: AM
authors.lastname: Roos-Jansåker
authors.forename: Helena
authors.initials: H
authors.lastname: Renvert
authors.forename: Christel
authors.initials: C
authors.lastname: Lindahl
authors.forename: Stefan
authors.initials: S
authors.lastname: Renvert
mesh_terms: D020341:Absorbable Implants; D000368:Aged; D016301:Alveolar Bone Loss / Q000601:surgery; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use; D018786:Bone Substitutes / Q000627:therapeutic use*; D015331:Cohort Studies; D015921:Dental Implants / Q000009:adverse effects*; D005260:Female; D005500:Follow-Up Studies; D005884:Gingival Hemorrhage / Q000601:surgery; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods*; D006801:Humans; D006861:Hydrogen Peroxide / Q000627:therapeutic use; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D016348:Osseointegration; D017622:Periodontal Attachment Loss / Q000601:surgery; D010518:Periodontitis / Q000601:surgery*; D011446:Prospective Studies; D016896:Treatment Outcome
chemical_list: C483718:Algipore; D000891:Anti-Infective Agents, Local; D018786:Bone Substitutes; D015921:Dental Implants; D008567:Membranes, Artificial; D006861:Hydrogen Peroxide