Exploiting a list of protein sequences.
We describe a software program to help exploit a database of aligned protein sequences. In addition to the classical lists of sequences, a graphical representation is used to get a better overview of the information. As natural parameters, the type of amino acid and sequence position are used. Various plots or 3D representations are then updated. Examples are shown based on globin sequences from various species and on the abnormal human hemoglobins. The software should be of interest to protein engineers who need to know what variants are already known.
Marden
Michael C
MC
Department of Biomedical Sciences, University of Antwerp, B-2610 Antwerp, Belgium. marden@kb.inserm.fr
Dewilde
Sylvia
S
Kiger
Laurent
L
Hamdane
Djemel
D
Uzan
Julien
J
Burmester
Thorsten
T
Hankeln
Thomas
T
Moens
Luc
L
Baudin-Creuza
Véronique
V
Celier
Chantal
C
Wajcman
Henri
H
D000595:Amino Acid Sequence; D000596:Amino Acids / Q000737:chemistry / Q000235:genetics; D000818:Animals; D003196:Computer Graphics; D030562:Databases, Protein; D006454:Hemoglobins / Q000737:chemistry* / Q000235:genetics; D006801:Humans; D008958:Models, Molecular; D009154:Mutation; D011487:Protein Conformation; D017434:Protein Structure, Tertiary; D012984:Software
D000596:Amino Acids; D006454:Hemoglobins