title: 16S rRNA methylase-producing, gram-negative pathogens, Japan.
abstract: To investigate the exact isolation frequency of 16S rRNA methylase-producing, gram-negative pathogenic bacteria, we tested 87,626 clinical isolates from 169 hospitals. Twenty-six strains from 16 hospitals harbored 16S rRNA methylase genes, which suggests sparse but diffuse spread of pan-aminoglycoside-resistant microbes in Japan.
authors.affiliation: National Institute of Infectious Diseases, Tokyo, Japan.
authors.forename: Kunikazu
authors.initials: K
authors.lastname: Yamane
authors.forename: Jun-ichi
authors.initials: J
authors.lastname: Wachino
authors.forename: Satowa
authors.initials: S
authors.lastname: Suzuki
authors.forename: Naohiro
authors.initials: N
authors.lastname: Shibata
authors.forename: Haru
authors.initials: H
authors.lastname: Kato
authors.forename: Keigo
authors.initials: K
authors.lastname: Shibayama
authors.forename: Kouji
authors.initials: K
authors.lastname: Kimura
authors.forename: Kumiko
authors.initials: K
authors.lastname: Kai
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ishikawa
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Ozawa
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Konda
authors.forename: Yoshichika
authors.initials: Y
authors.lastname: Arakawa
mesh_terms: D000617:Aminoglycosides / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D003982:Dibekacin / Q000031:analogs & derivatives / Q000494:pharmacology; D024881:Drug Resistance, Bacterial; D016521:Electrophoresis, Gel, Pulsed-Field; D005260:Female; D006090:Gram-Negative Bacteria / Q000187:drug effects* / Q000201:enzymology* / Q000235:genetics / Q000302:isolation & purification; D016905:Gram-Negative Bacterial Infections / Q000382:microbiology*; D006801:Humans; D007564:Japan; D008780:Methyltransferases / Q000235:genetics*; D008826:Microbial Sensitivity Tests; D012336:RNA, Ribosomal, 16S / Q000235:genetics
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D012336:RNA, Ribosomal, 16S; D003982:Dibekacin; D008780:Methyltransferases; C035181:rRNA (adenosine-O-2'-)methyltransferase; C031986:arbekacin