Repairing brain after stroke: a review on post-ischemic neurogenesis.
Stroke is devastating as currently no therapies are available that can prevent stroke-induced neurological dysfunction in humans. With the recent observations that acute insults to adult brain stimulate new neuronal formation in various species of animals, optimism is building for a possible regeneration of stroke-damaged brain. This article reviewed the advances in the understanding of the molecular mechanisms of the various steps of neurogenesis with an emphasis on the endogenous mediators and exogenous promoters of neural progenitor proliferation, migration and survival in the post-ischemic adult brain.
Wiltrout
Charles
C
Department of Neurological Surgery, University of Wisconsin, Madison, WI, USA.
Lang
Bradley
B
Yan
Yiping
Y
Dempsey
Robert J
RJ
Vemuganti
Raghu
R
D000328:Adult; D000818:Animals; D001921:Brain / Q000502:physiology* / Q000503:physiopathology; D002545:Brain Ischemia / Q000503:physiopathology* / Q000534:rehabilitation; D002552:Cerebral Ventricles / Q000503:physiopathology; D018891:Dentate Gyrus / Q000503:physiopathology; D006624:Hippocampus / Q000503:physiopathology; D006801:Humans; D007249:Inflammation; D007334:Insulin-Like Growth Factor I / Q000502:physiology; D009416:Nerve Regeneration / Q000502:physiology*; D018377:Neurotransmitter Agents / Q000502:physiology; D009569:Nitric Oxide / Q000502:physiology; D020521:Stroke / Q000503:physiopathology*; D000071939:Stroke Rehabilitation
D018377:Neurotransmitter Agents; D009569:Nitric Oxide; D007334:Insulin-Like Growth Factor I