title: Early pediatric anthracycline cardiotoxicity: managed by serial heart and bone marrow transplantation.
abstract: We report a favorable outcome in a child who underwent cardiac transplantation for severe early post-anthracycline-induced cardiomyopathy, 9 months after completion of treatment for acute myeloid leukemia (AML). The child suffered a relapse of AML 2 months after cardiac transplantation and then underwent a successful bone marrow transplant. This case is unique in the literature. We believe it offers an alternative strategy for children with hematologic malignancies, where severe early post-anthracycline cardiotoxicity might preclude bone marrow transplantation.
authors.affiliation: Department of Paediatric Cardiology, Great Ormond Street Hospital, London, UK. jasveer_mangat@yahoo.com
authors.forename: Jasveer S
authors.initials: JS
authors.lastname: Mangat
authors.forename: Kanchan
authors.initials: K
authors.lastname: Rao
authors.forename: Judith
authors.initials: J
authors.lastname: Kingston
authors.forename: Paul
authors.initials: P
authors.lastname: Veys
authors.forename: Persis
authors.initials: P
authors.lastname: Amrolia
authors.forename: Michael
authors.initials: M
authors.lastname: Burch
mesh_terms: D018943:Anthracyclines / Q000633:toxicity*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D016026:Bone Marrow Transplantation; D002648:Child; D016027:Heart Transplantation; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy*; D008297:Male; D010198:Pancytopenia / Q000209:etiology; D012008:Recurrence; D017741:Survivors
chemical_list: D018943:Anthracyclines