title: Relationship between lactate dehydrogenase activity in saliva and oral health status.
abstract: OBJECTIVE
  Lactate dehydrogenase (LDH) activity in serum increases as a marker of cellular necrosis. LDH activity in saliva could constitute a specific indicator of oral mucosal lesions with tissue breakdown including periodontal disease. The aim of this study was to determine LDH activity in saliva, assessing inter-individual variations with regard to the oral health status.
  
  
  METHODS
  An oral and perioral examination was performed on a study group of 175 volunteers, to assess the number of missing teeth, caries, fillings, dental prosthesis, periodontal status and temporomandibular joint condition. LDH activity was determined from stimulated whole saliva.
  
  
  RESULTS
  After adjustment by age, gender, smoking habits, missing teeth and use of removable prosthesis, the multivariate analysis showed that increased LDH activity was associated with periodontal disease, specifically with the presence of calculus and pockets greater than 5mm.
  
  
  CONCLUSIONS
  LDH activity in whole saliva could be useful as a biochemical marker of periodontal status.
authors.affiliation: School of Medicine and Dentistry, University of Santiago de Compostela, Entrerríos, s/n. 15782 Santiago de Compostela, Spain.
authors.forename: Víctor Alonso
authors.initials: VA
authors.lastname: De La Peña
authors.forename: Pedro
authors.initials: P
authors.lastname: Diz Dios
authors.forename: Rafael
authors.initials: R
authors.lastname: Tojo Sierra
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000378:metabolism; D005260:Female; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000201:enzymology; D015999:Multivariate Analysis; D009909:Oral Health; D009911:Oral Hygiene Index; D010510:Periodontal Diseases / Q000453:epidemiology*; D011237:Predictive Value of Tests; D012463:Saliva / Q000201:enzymology*
chemical_list: D015415:Biomarkers; D007770:L-Lactate Dehydrogenase