title: Tone burst-galvanic ratio of vestibular evoked myogenic potential amplitudes: a new parameter of vestibular evoked myogenic potential?
abstract: OBJECTIVE
  To clarify whether the ratio of tone burst vestibular evoked myogenic potential (VEMP) amplitude to galvanic (electric) VEMP amplitude can be a useful indicator of peripheral vestibular disorders, especially labyrinthine disorders.
  
  
  METHODS
  Twelve healthy volunteers and 12 patients with endolymphatic hydrops (EH) were enrolled in this study. VEMP was recorded using 500 Hz short tone bursts (135dBSPL, rise/fall time 1 ms, plateau time 2 ms) and galvanic stimulation (3 mA, 1 ms). Amplitudes of p13-n23 (tone burst) and p13g-n23g (galvanic) were corrected using background muscle activity. We defined the ratio of the corrected amplitude of p13-n23 to the corrected amplitude of p13g-n23g as TGratio.
  
  
  RESULTS
  The mean+/-SD of logarithmic value of TGratio (LTGratio) of healthy volunteers was 0.34+/-0.12. LTGratios in patients were 0.002+/-0.24 on the affected side and 0.34+/-0.14 on the unaffected side. LTGratio on the affected side of patients was significantly smaller than the ratio on the unaffected side and the ratio of healthy volunteers. Among the 12 patients with EH, 8 patients (66%) had significantly decreased LTGratio (smaller than mean-2SD of healthy volunteers).
  
  
  CONCLUSIONS
  Patients with EH had decreased ratio of tone burst VEMP amplitude to galvanic VEMP amplitude.
  
  
  CONCLUSIONS
  TGratio (or LTGratio) could be a new promising parameter of VEMP as it can be calculated from results of one side.
authors.affiliation: Department of Otolaryngology, Tokyo Postal Services Agency Hospital, and Department of Otolaryngology, University of Tokyo, Japan. toshi-tky@umin.ac.jp
authors.forename: Toshihisa
authors.initials: T
authors.lastname: Murofushi
authors.forename: Shinichi
authors.initials: S
authors.lastname: Iwasaki
authors.forename: Hidenori
authors.initials: H
authors.lastname: Ozeki
authors.forename: Munetaka
authors.initials: M
authors.lastname: Ushio
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Chihara
mesh_terms: D000161:Acoustic Stimulation; D000328:Adult; D004558:Electric Stimulation; D004576:Electromyography; D018159:Endolymphatic Hydrops / Q000175:diagnosis / Q000503:physiopathology*; D019054:Evoked Potentials, Motor; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009334:Neck Muscles / Q000503:physiopathology*; D014722:Vestibule, Labyrinth / Q000503:physiopathology*