The discovery of basic fibroblast growth factor/fibroblast growth factor-2 and its role in haematological malignancies.
Basic fibroblast growth factor/fibroblast growth factor-2 is one of the best characterized of the pro-angiogenic cytokines. This review describes its history, as well as its role in tumor angiogenesis associated with haematological malignancies, as traced by the main contributions to the international medical literature.
Ribatti
Domenico
D
Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy. ribatti@anatomia.uniba.it
Vacca
Angelo
A
Rusnati
Marco
M
Presta
Marco
M
D000818:Animals; D045744:Cell Line, Tumor; D016222:Fibroblast Growth Factor 2 / Q000378:metabolism* / Q000502:physiology*; D015972:Gene Expression Regulation, Neoplastic; D019337:Hematologic Neoplasms / Q000378:metabolism*; D006801:Humans; D008223:Lymphoma / Q000378:metabolism; D008954:Models, Biological; D009389:Neovascularization, Pathologic; D017468:Receptors, Fibroblast Growth Factor / Q000378:metabolism
D017468:Receptors, Fibroblast Growth Factor; D016222:Fibroblast Growth Factor 2