title: Pneumatosis intestinalis and portal venous gas without bowel ischemia in a patient treated with irinotecan and cisplatin.
abstract: Pneumatosis intestinalis and gas within the portal venous system are findings predictive of bowel ischemia. The etiologies of these alarming radiographic signs are diverse and not all causes require emergent surgical intervention. The combination of pneumatosis intestinalis, portal venous gas, and acidosis typically portends bowel ischemia and inevitable necrosis. This case report is the first description of benign pneumatosis and portal venous gas secondary to irinotecan and cisplatin.
authors.affiliation: Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: David
authors.initials: D
authors.lastname: Kung
authors.forename: Daniel T
authors.initials: DT
authors.lastname: Ruan
authors.forename: Rodney K
authors.initials: RK
authors.lastname: Chan
authors.forename: Melissa L
authors.initials: ML
authors.lastname: Ericsson
authors.forename: Mandeep S
authors.initials: MS
authors.lastname: Saund
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002166:Camptothecin / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D002945:Cisplatin / Q000009:adverse effects* / Q000627:therapeutic use; D003106:Colon / Q000098:blood supply; D003937:Diagnosis, Differential; D004618:Embolism, Air / Q000139:chemically induced* / Q000000981:diagnostic imaging; D004938:Esophageal Neoplasms / Q000188:drug therapy; D005500:Follow-Up Studies; D006801:Humans; D007421:Intestine, Small / Q000098:blood supply; D000077146:Irinotecan; D007511:Ischemia / Q000175:diagnosis* / Q000601:surgery; D007813:Laparotomy; D008297:Male; D011006:Pneumatosis Cystoides Intestinalis / Q000139:chemically induced* / Q000000981:diagnostic imaging; D011169:Portal Vein; D011355:Prodrugs; D014057:Tomography, X-Ray Computed
chemical_list: D000970:Antineoplastic Agents; D011355:Prodrugs; D000077146:Irinotecan; D002945:Cisplatin; D002166:Camptothecin