Synthesis and antitumour activity of new tiazofurin analogues bearing a 2,3-anhydro functionality in the furanose ring.
This paper describes a divergent de novo synthesis of 2-(2,3-anhydro-beta-dribofuranosyl)thiazole-4-carboxamide (2',3'-anhydro-tiazofurin) and the corresponding alpha- and beta-homo-C-nucleosides, as well as evaluation of their antitumour activities in vitro.
Popsavin
Mirjana
M
Department of Chemistry, Faculty of Sciences, University of Novi Sad, Trg D. Obradovića 3, 21000 Novi Sad, Serbia. mpopsavin@ih.ns.ac.yu
Spaić
Sasa
S
Svircev
Milos
M
Kojić
Vesna
V
Bogdanović
Gordana
G
Popsavin
Velimir
V
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D005663:Furans / Q000737:chemistry; D007168:IMP Dehydrogenase / Q000037:antagonists & inhibitors; D012254:Ribavirin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
D000970:Antineoplastic Agents; D005663:Furans; D012254:Ribavirin; D007168:IMP Dehydrogenase; C033706:tiazofurin