title: Evaluation of clinical status, renal function, and hematopoietic variables after unilateral nephrectomy in canine kidney donors.
abstract: OBJECTIVE
  To determine clinical status and renal and hematopoietic function after kidney donation and identify risks associated with kidney donation in dogs.
  
  
  METHODS
  Prospective study.
  
  
  METHODS
  14 dogs that underwent unilateral nephrectomy for kidney donation.
  
  
  METHODS
  Records were reviewed retrospectively to collect data regarding prenephrectomy clinicopathologic variables. Dogs were reexamined prospectively at various times after nephrectomy, and pre- and postnephrectomy CBC, serum biochemical analyses, urinalysis, and urine protein-to-urine creatinine ratio were compared. Six dogs had postnephrectomy renal volume determined ultrasonographically, and 4 of those dogs also underwent scintigraphic determination of glomerular filtration rate and renal biopsy.
  
  
  RESULTS
  All dogs were clinically normal at the time of reevaluation. There were no significant differences between prenephrectomy and postnephrectomy values for BUN concentration or urine specific gravity. Mean postnephrectomy serum creatinine concentration was significantly greater than prenephrectomy concentration. Mean serum phosphorus concentration was significantly decreased after nephrectomy, and mean Hct, corpuscular volume, and corpuscular hemoglobin concentration were significantly increased after nephrectomy. Postnephrectomy renal volume was greatest in dogs < 12 months old at the time of surgery. Mean postnephrectomy glomerular filtration rate was 2.82 +/- 1.12 mL/kg/ min (1.28 +/- 0.51 mL/lb/min). Renal biopsy specimens obtained during and after nephrectomy were histologically normal.
  
  
  CONCLUSIONS
  Renal and hematopoietic variables were within reference ranges in dogs examined up to 2.5 years after unilateral nephrectomy. Compensatory renal hypertrophy was greatest in dogs < 1 year of age at donation. Donor age, along with histocompatability, may be an important factor in selecting dogs for kidney donation.
authors.affiliation: Department of Clinical Sciences, College of Veterinary Medicine, Auburn University, Auburn, AL 36849, USA.
authors.forename: Bridget K
authors.initials: BK
authors.lastname: Urie
authors.forename: D Michael
authors.initials: DM
authors.lastname: Tillson
authors.forename: Christopher M
authors.initials: CM
authors.lastname: Smith
authors.forename: William R
authors.initials: WR
authors.lastname: Brawner
authors.forename: Gregory T
authors.initials: GT
authors.lastname: Almond
authors.forename: Debra M
authors.initials: DM
authors.lastname: Beard
authors.forename: Stephen D
authors.initials: SD
authors.lastname: Lenz
authors.forename: Clinton D
authors.initials: CD
authors.lastname: Lothrop
mesh_terms: D000367:Age Factors; D000818:Animals; D001806:Blood Urea Nitrogen; D003404:Creatinine / Q000097:blood; D004285:Dogs; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology / Q000662:veterinary; D006648:Histocompatibility; D007668:Kidney / Q000502:physiology*; D007677:Kidney Function Tests / Q000379:methods / Q000662:veterinary; D016030:Kidney Transplantation / Q000502:physiology / Q000662:veterinary*; D019520:Living Donors; D008297:Male; D009392:Nephrectomy / Q000009:adverse effects / Q000662:veterinary*; D010758:Phosphorus / Q000097:blood; D011446:Prospective Studies; D013997:Time Factors
chemical_list: D010758:Phosphorus; D003404:Creatinine