title: Hyperglycemia in patients with acute myeloid leukemia is associated with increased hospital mortality.
abstract: BACKGROUND
  Hyperglycemia is often observed in medically ill patients. Previous studies have shown that patients with hyperglycemia during induction therapy for acute lymphoblastic leukemia develop more infections and have shorter disease-free survival. The authors hypothesized that hyperglycemia may be associated with adverse outcomes in patients with acute myeloid leukemia (AML) and sought to determine whether this association exists in this population.
  
  
  METHODS
  The authors performed a retrospective cohort study to examine the relation between hyperglycemia and hospital mortality in patients with the diagnosis of AML. Two hundred eighty-three adult patients were treated over a 3-year period. All hospitalizations were reviewed during the study period, and glucose exposure and outcomes were quantified.
  
  
  RESULTS
  Hyperglycemia during a patient's hospitalization was associated with increased hospital mortality (OR, 1.38; 95% CI, 1.23-1.55; P < .001) after adjusting for covariates, including disease state, treatment type, and response. The rise in mortality was evident at even mild levels (110-150 mg/dL) of glucose elevation. Although the odds of developing severe sepsis (OR, 1.24; 95% CI, 1.13.-1.38; P < .001) or severe sepsis with respiratory failure (OR, 2.04; 95% CI, 1.44-2.91; P < .001) were increased with hyperglycemia, sepsis did not appear to be the main factor responsible for the negative impact of hyperglycemia on hospital mortality.
  
  
  CONCLUSIONS
  This study demonstrated an association between hospital mortality and even modest levels of hyperglycemia in AML patients. Prospective studies are needed to confirm this association and to discern causal pathways that mediate this effect.
authors.affiliation: Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, Ohio State University, Columbus, Ohio 43210, USA. Naeem.ali@osumc.edu
authors.forename: Naeem A
authors.initials: NA
authors.lastname: Ali
authors.forename: James M
authors.initials: JM
authors.lastname: O'Brien
authors.forename: William
authors.initials: W
authors.lastname: Blum
authors.forename: John C
authors.initials: JC
authors.lastname: Byrd
authors.forename: Rebecca B
authors.initials: RB
authors.lastname: Klisovic
authors.forename: Guido
authors.initials: G
authors.lastname: Marcucci
authors.forename: Gary
authors.initials: G
authors.lastname: Phillips
authors.forename: Clay B
authors.initials: CB
authors.lastname: Marsh
authors.forename: Stanley
authors.initials: S
authors.lastname: Lemeshow
authors.forename: Michael R
authors.initials: MR
authors.lastname: Grever
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D015331:Cohort Studies; D005260:Female; D017052:Hospital Mortality; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D006943:Hyperglycemia / Q000150:complications*; D007951:Leukemia, Myeloid / Q000097:blood / Q000150:complications / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D009820:Ohio; D012131:Respiratory Insufficiency / Q000150:complications; D012189:Retrospective Studies; D018805:Sepsis / Q000150:complications; D015996:Survival Rate; D013997:Time Factors
chemical_list: D001786:Blood Glucose