title: Major depression among medically ill elders contributes to sustained poor mental health in their informal caregivers.
abstract: BACKGROUND
  No longitudinal studies have addressed the effect of late life depression on the physical and mental health status of their informal caregivers.
  
  
  OBJECTIVE
  To examine whether a diagnosis of depression in older medical inpatients is associated with the physical and mental health status of their informal caregivers after 6 months, independent of the physical health of the care recipient.
  
  
  METHODS
  Longitudinal observational study with 6-month follow-up.
  
  
  METHODS
  Two Montreal acute-care hospitals.
  
  
  METHODS
  A sample of 97 cognitively intact medical inpatients aged 65 and over and their informal caregivers, with oversampling of patients with a diagnosis of major or minor depression.
  
  
  METHODS
  Patient data included depression (current diagnosis, duration of current diagnosis, severity of symptoms, and history of depression), physical health (severity of illness, comorbidity, premorbid disability), and cognitive impairment. Caregiver data included relationship to patient, co-residence, and the physical and mental health status subscales of the SF-36. Multivariate linear regression analyses were conducted to determine the relationship between patient depression and caregiver 6 month SF-36 physical and mental scores, adjusting for baseline values, patient comorbidity, disability, and other patient and caregiver variables.
  
  
  RESULTS
  Patient characteristics included: mean age 79.3, 62% female, 46% major depression, 18% minor depression, 36% no depression. Caregiver characteristics included: 73% female, 35% co-resident spouse, 15% other co-resident relation, 50% not residing with the patient. Results of the multivariate analyses showed that in comparison with caregivers of patients without a current diagnosis of depression, caregivers of those with major depression had a lower mental health score at follow-up (-9.54, 95% CI -16.66, -2.43), even though their physical health was slightly better (5.42 95% CI 0.04, 10.81).
  
  
  CONCLUSIONS
  A diagnosis of major depression in older medical inpatients is independently associated with poor mental health in their informal caregivers 6 months later.
authors.affiliation: Department of Clinical Epidemiology and Community Studies, St. Mary's Hospital, Canada. jane.mccusker@mcgill.ca
authors.forename: Jane
authors.initials: J
authors.lastname: McCusker
authors.forename: Eric
authors.initials: E
authors.lastname: Latimer
authors.forename: Martin
authors.initials: M
authors.lastname: Cole
authors.forename: Antonio
authors.initials: A
authors.lastname: Ciampi
authors.forename: Maida
authors.initials: M
authors.lastname: Sewitch
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000523:psychology*; D017028:Caregivers / Q000523:psychology*; D003071:Cognition / Q000502:physiology; D003865:Major Depressive Disorder / Q000451:nursing* / Q000523:psychology*; D005260:Female; D005500:Follow-Up Studies; D015577:Geriatric Assessment; D006304:Health Status; D006801:Humans; D016014:Linear Models; D008297:Male; D008603:Mental Health; D015999:Multivariate Analysis; D012720:Severity of Illness Index; D013315:Stress, Psychological / Q000523:psychology