title: High-frequency electrocardiogram analysis in the ability to predict reversible perfusion defects during adenosine myocardial perfusion imaging.
abstract: BACKGROUND
  A previous study has shown that analysis of high-frequency QRS components (HF-QRS) is highly sensitive and reasonably specific for detecting reversible perfusion defects on adenosine myocardial perfusion imaging (MPI) scans. The purpose of the present study was to try to reproduce those findings.
  
  
  METHODS
  Twelve-lead high-resolution electrocardiogram recordings were obtained from 100 patients before (baseline) and during adenosine (99m)Tc-tetrofosmin MPI tests. The HF-QRS were analyzed regarding morphology and changes in root mean square voltages from before the adenosine infusion to peak infusion.
  
  
  RESULTS
  The best area under the curve (AUC) was found in supine patients (AUC = 0.736) in a combination of morphology and root mean square changes. None of the measurements, however, were statistically better than tossing a coin (AUC = 0.5).
  
  
  CONCLUSIONS
  Analysis of HF-QRS was not significantly better than tossing a coin for determining reversible perfusion defects on MPI scans.
authors.affiliation: Department of Clinical Physiology, Lund University Hospital, Lund, Sweden. Elin.tragardh@med.lu.se
authors.forename: Elin
authors.initials: E
authors.lastname: Trägårdh
authors.forename: Todd T
authors.initials: TT
authors.lastname: Schlegel
authors.forename: Marcus
authors.initials: M
authors.lastname: Carlsson
authors.forename: Jonas
authors.initials: J
authors.lastname: Pettersson
authors.forename: Klas
authors.initials: K
authors.lastname: Nilsson
authors.forename: Olle
authors.initials: O
authors.lastname: Pahlm
mesh_terms: D000241:Adenosine; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D004562:Electrocardiography / Q000379:methods*; D005260:Female; D006352:Heart Ventricles / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009943:Organophosphorus Compounds; D015609:Organotechnetium Compounds; D011379:Prognosis; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014665:Vasodilator Agents; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis*
chemical_list: D009943:Organophosphorus Compounds; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; D014665:Vasodilator Agents; C078700:technetium tc-99m tetrofosmin; D000241:Adenosine