title: Basic fibroblast growth factor promotes bone marrow stromal cell transplantation-mediated neural regeneration in traumatic brain injury.
abstract: The current study was designed to evaluate the effects of basic fibroblast growth factor (bFGF) on human BMSC (hBMSC) transplantation-mediated neural regeneration in traumatic brain injury (TBI). Fibrin gel was used as a delivery vehicle to release bFGF locally in the TBI sites in a controlled manner. To test this hypothesis, hBMSCs suspended in fibrin gel containing bFGF were transplanted to rat TBI sites. Transplantation of hBMSCs suspended in fibrin gel without bFGF served as a control. hBMSC transplantation and bFGF treatment showed enhanced neural tissue regeneration than that of the control. The infarction volume and apoptotic activity of the transplanted hBMSCs were significantly decreased, and functional outcomes were significantly improved in the hBMSC transplantation and bFGF treatment group than in the control group. This study demonstrates that bFGF significantly enhances histological and functional recovery when used in hBMSC transplantation therapy in TBI.
authors.affiliation: Department of Bioengineering, Hanyang University, Seoul 133-791, Republic of Korea.
authors.forename: Suk Ho
authors.initials: SH
authors.lastname: Bhang
authors.forename: Young Eun
authors.initials: YE
authors.lastname: Lee
authors.forename: Seung-Woo
authors.initials: SW
authors.lastname: Cho
authors.forename: Jae-Won
authors.initials: JW
authors.lastname: Shim
authors.forename: Sang-Hun
authors.initials: SH
authors.lastname: Lee
authors.forename: Cha Yong
authors.initials: CY
authors.lastname: Choi
authors.forename: Jin Woo
authors.initials: JW
authors.lastname: Chang
authors.forename: Byung-Soo
authors.initials: BS
authors.lastname: Kim
mesh_terms: D000818:Animals; D001930:Brain Injuries / Q000473:pathology* / Q000628:therapy*; D003131:Combined Modality Therapy; D004337:Drug Carriers / Q000737:chemistry; D005337:Fibrin / Q000737:chemistry; D016222:Fibroblast Growth Factor 2 / Q000008:administration & dosage*; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods*; D059630:Mesenchymal Stem Cells / Q000187:drug effects; D009416:Nerve Regeneration / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley; D017154:Stromal Cells / Q000187:drug effects / Q000637:transplantation; D016896:Treatment Outcome
chemical_list: D004337:Drug Carriers; D016222:Fibroblast Growth Factor 2; D005337:Fibrin