Building blood vessels--stem cell models in vascular biology.
Spheroids of differentiating embryonic stem cells, denoted embryoid bodies, constitute a high-quality model for vascular development, particularly well suited for loss-of-function analysis of genes required for early embryogenesis. This review examines vasculogenesis and angiogenesis in murine embryoid bodies and discusses the promise of stem cell-based models for the study of human vascular development.
Jakobsson
Lars
L
Department of Genetics and Pathology, Uppsala University, SE-751 85 Uppsala, Sweden.
Kreuger
Johan
J
Claesson-Welsh
Lena
L
D000818:Animals; D002454:Cell Differentiation; D053595:Embryonic Stem Cells / Q000166:cytology*; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D018919:Neovascularization, Physiologic / Q000235:genetics / Q000502:physiology*