title: Heterocyclic alpha-helix mimetics for targeting protein-protein interactions.
abstract: The design and synthesis of alpha-helix peptidomimetics using inverse electron demand Diels-Alder reactions is described. The potency of the resulting pyridazine-based library to disrupt the Bak/Bcl-X(L) interaction was tested using an in vitro fluorescence polarization assay.
authors.affiliation: The Skaggs Institute for Chemical Biology, The Scripps Research Institute, Mail MB-26, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
authors.forename: Shannon M
authors.initials: SM
authors.lastname: Biros
authors.forename: Lionel
authors.initials: L
authors.lastname: Moisan
authors.forename: Enrique
authors.initials: E
authors.lastname: Mann
authors.forename: Alexandre
authors.initials: A
authors.lastname: Carella
authors.forename: Dayong
authors.initials: D
authors.lastname: Zhai
authors.forename: John C
authors.initials: JC
authors.lastname: Reed
authors.forename: Julius
authors.initials: J
authors.lastname: Rebek
mesh_terms: D006571:Heterocyclic Compounds / Q000737:chemistry*; D008958:Models, Molecular; D011485:Protein Binding; D017433:Protein Structure, Secondary; D050998:bcl-2 Homologous Antagonist-Killer Protein / Q000737:chemistry; D051020:bcl-X Protein / Q000737:chemistry
chemical_list: D006571:Heterocyclic Compounds; D050998:bcl-2 Homologous Antagonist-Killer Protein; D051020:bcl-X Protein