title: OMA Browser--exploring orthologous relations across 352 complete genomes.
abstract: BACKGROUND
  Inference of the evolutionary relation between proteins, in particular the identification of orthologs, is a central problem in comparative genomics. Several large-scale efforts with various methodologies and scope tackle this problem, including OMA (the Orthologous MAtrix project).
  
  
  RESULTS
  Based on the results of the OMA project, we introduce here the OMA Browser, a web-based tool allowing the exploration of orthologous relations over 352 complete genomes. Orthologs can be viewed as groups across species, but also at the level of sequence pairs, allowing the distinction among one-to-one, one-to-many and many-to-many orthologs.
  
  
  BACKGROUND
  http://omabrowser.org.
authors.affiliation: Institute of Computational Science, ETH Zurich, Switzerland. schneadr@inf.ethz.ch
authors.forename: Adrian
authors.initials: A
authors.lastname: Schneider
authors.forename: Christophe
authors.initials: C
authors.lastname: Dessimoz
authors.forename: Gaston H
authors.initials: GH
authors.lastname: Gonnet
mesh_terms: D020137:Base Pair Mismatch / Q000235:genetics; D001483:Base Sequence; D002874:Chromosome Mapping / Q000379:methods*; D003196:Computer Graphics; D017124:Conserved Sequence / Q000235:genetics*; D019143:Evolution, Molecular; D008969:Molecular Sequence Data; D016415:Sequence Alignment / Q000379:methods*; D017422:Sequence Analysis, DNA / Q000379:methods*; D012689:Sequence Homology, Nucleic Acid; D012984:Software