title: Rituximab as a treatment option for refractory endogenous anterior uveitis.
abstract: BACKGROUND
  To report on anti-CD20 antibody therapy in a patient with uveitis refractive to immunosuppression therapy.
  
  
  METHODS
  Case report with ophthalmoscopic, optical coherence tomography and fluorescein-angiographic findings.
  
  
  RESULTS
  A 49-year-old woman was suffering from bilateral, noninfectious chronic anterior uveitis refractive to corticosteroids and immunosuppressive drugs. Bilateral visual acuity was 20/100 due to cataract and cystoid macular edema (CME). After treatment with rituximab, vision and CME improved, and uveitis was stable until the final visit (follow-up at 12 months).
  
  
  CONCLUSIONS
  The case report suggests that rituximab may be helpful for selected patients with chronic anterior uveitis refractive to corticosteroids and immunosuppressive medication.
authors.affiliation: Department of Ophthalmology, St. Franziskus Hospital, Muenster, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Tappeiner
authors.forename: C
authors.initials: C
authors.lastname: Heinz
authors.forename: C
authors.initials: C
authors.lastname: Specker
authors.forename: A
authors.initials: A
authors.lastname: Heiligenhaus
mesh_terms: D000911:Antibodies, Monoclonal / Q000008:administration & dosage / Q000627:therapeutic use*; D058846:Antibodies, Monoclonal, Murine-Derived; D018951:Antigens, CD20; D002908:Chronic Disease; D005260:Female; D005451:Fluorescein Angiography; D005500:Follow-Up Studies; D005654:Fundus Oculi; D006801:Humans; D007155:Immunologic Factors / Q000008:administration & dosage / Q000627:therapeutic use*; D007262:Infusions, Intravenous; D008875:Middle Aged; D009887:Ophthalmoscopy; D000069283:Rituximab; D041623:Tomography, Optical Coherence; D014606:Uveitis, Anterior / Q000188:drug therapy* / Q000473:pathology
chemical_list: D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D018951:Antigens, CD20; D007155:Immunologic Factors; D000069283:Rituximab