bZIPDB: a database of regulatory information for human bZIP transcription factors.
BACKGROUND
Basic region-leucine zipper (bZIP) proteins are a class of transcription factors (TFs) that play diverse roles in eukaryotes. Malfunctions in these proteins lead to cancer and various other diseases. For detailed characterization of these TFs, further public resources are required.


METHODS
We constructed a database, designated bZIPDB, containing information on 49 human bZIP TFs, by means of automated literature collection and manual curation. bZIPDB aims to provide public data required for deciphering the gene regulatory network of the human bZIP family, e.g., evaluation or reference information for the identification of regulatory modules. The resources provided by bZIPDB include (1) protein interaction data including direct binding, phosphorylation and functional associations between bZIP TFs and other cellular proteins, along with other types of interactions, (2) bZIP TF-target gene relationships, (3) the cellular network of bZIP TFs in particular cell lines, and (4) gene information and ontology. In the current version of the database, 721 protein interactions and 560 TF-target gene relationships are recorded. bZIPDB is annually updated for the newly discovered information.


CONCLUSIONS
bZIPDB is a repository of detailed regulatory information for human bZIP TFs that is collected and processed from the literature, designed to facilitate analysis of this protein family. bZIPDB is available for public use at http://biosoft.kaist.ac.kr/bzipdb.
Ryu
Taewoo
T
Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology, Guseong-dong, Yuseong-gu, Daejeon, Korea. twryu@biosoft.kaist.ac.kr <twryu@biosoft.kaist.ac.kr>
Jung
Juhyun
J
Lee
Sunjae
S
Nam
Ho Jung
HJ
Hong
Sun Woo
SW
Yoo
Jae Wook
JW
Lee
Dong-ki
DK
Lee
Doheon
D
D000465:Algorithms; D000818:Animals; D050976:Basic-Leucine Zipper Transcription Factors / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism / Q000502:physiology*; D019556:COS Cells; D002460:Cell Line; D002522:Chlorocebus aethiops; D002874:Chromosome Mapping; D030541:Databases, Genetic; D053263:Gene Regulatory Networks / Q000502:physiology; D006367:HeLa Cells; D006801:Humans; D019169:Jurkat Cells; D051379:Mice; D041681:NIH 3T3 Cells; D011485:Protein Binding; D025941:Protein Interaction Mapping; D015533:Transcriptional Activation / Q000502:physiology
D050976:Basic-Leucine Zipper Transcription Factors