[Prenatal diagnosis of Thailand deletion of alpha-thalassemia 1].
OBJECTIVE
To conduct prenatal diagnosis on the couples carrying Thailand deletion (--THAI) alpha-thalassemia 1 and at high risk of having fetus with alpha-thalassemia.


METHODS
Genotypes of couples and fetuses were analyzed by PCR and DNA sequencing.


RESULTS
Four pregnant women were patients with Hb H diseases of --THAI compounding with alpha-thalassemia 2, while their husbands were heterozygote of the Southeast Asian type alpha-thalassemia 1 (--SEA). Another 5 families, either husbands or wives were heterozygote of --THAI or --SEA. The genotypes of their fetuses were as follows: 2 cases with Hb Bart's hydrops fetalis syndrome, 1 Hb H disease, 4 alpha-thalassemia heterozygote and 2 normal. The DNA sequencing approved the PCR results.


CONCLUSIONS
The study on prenatal diagnosis of Thailand deletion alpha-thalassemia 1 is of importance to the genetic counseling and prenatal diagnosis of alpha-thalassemia.
Chen
Ping
P
Hemoglobin Laboratory, First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, 530021 PR China. cping62@hotmail.com
Li
Shu-quan
SQ
Li
Min-qing
MQ
Pang
Li-hong
LH
Lin
Wei-xiong
WX
D000328:Adult; D001483:Base Sequence; D005260:Female; D005315:Fetal Diseases / Q000097:blood / Q000175:diagnosis* / Q000235:genetics*; D005838:Genotype; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D008297:Male; D011247:Pregnancy; D011296:Prenatal Diagnosis; D017422:Sequence Analysis, DNA; D017384:Sequence Deletion / Q000235:genetics*; D017085:alpha-Thalassemia / Q000097:blood / Q000175:diagnosis* / Q000235:genetics*
D006454:Hemoglobins