Filling a GAP(DH) in caspase-independent cell death.
Mitochondrial outer-membrane permeabilization can lead to cell death even without activation of caspases. In this issue of Cell, Colell et al. (2007) identify the glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase as a potent inhibitor of caspase-independent cell death that may allow metabolically active cells to survive mitochondrial insult.
Rathmell
Jeffrey C
JC
Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA.
Kornbluth
Sally
S
D017209:Apoptosis; D020169:Caspases / Q000378:metabolism; D045744:Cell Line, Tumor; D002470:Cell Survival; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases / Q000502:physiology*; D006801:Humans; D008928:Mitochondria / Q000378:metabolism; D051336:Mitochondrial Membranes / Q000378:metabolism
D005987:Glyceraldehyde-3-Phosphate Dehydrogenases; D020169:Caspases