[Perspectives in cardiac cell therapy].
The objective of cardiac cell therapy is to restore a certain degree of functionality of the infarct zones by injecting stem cells. This therapy was tested primarily in two clinical fields: chronic heart failure and acute myocardial infarction. Clinical trials have showed safety of cardiac cell therapy and encouraging efficacy results. Three challenges for on optimal therapeutic benefit: prevent cells migration, increase their survival and improve their integration within the recipient myocardium. Many perspectives exist in the field of regeneration of cardiac tissue.
Menasché
Philippe
P
Hôpitaux de Paris, Hôpital européen Georges-Pompidou, Département de Chirurgie Cardio-vasculaire, Université Paris Descartes, Faculté de Médecine; INSERM U 633, AP-HP, Paris (75), France. philippe.menasche@hop.egp.ap-hop-paris.fr
D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use; D006333:Heart Failure / Q000628:therapy*; D006801:Humans; D032446:Myoblasts / Q000637:transplantation*; D009203:Myocardial Infarction / Q000628:therapy*; D033581:Stem Cell Transplantation
D016179:Granulocyte Colony-Stimulating Factor