title: Genetic regulation of arrested development in nematodes: are age-1 and daf-gene orthologs present in Dictyocaulus viviparus?
abstract: In opposite to the free-living soil nematode Caenorhabditis elegans, the genetic regulation of hypobiosis or inhibited or arrested development in parasitic nematodes is completely unknown. In C. elegans, the daf-genes or the age-1 gene are of major importance in signaling pathways regulating arrested development. To investigate if orthologs of these genes are present in the bovine lungworm Dictyocaulus viviparus, a PCR analysis with gene-specific primer combinations was performed. No orthologs of the age-1 or daf-genes could be identified in D. viviparus. The possible differences in the role of the daf-genes concerning arrested development in parasitic and free-living nematodes will be discussed.
authors.affiliation: Institute for Parasitology, University of Veterinary Medicine Hannover, Buenteweg, 17, 30559 Hannover, Germany. christina.strube@tiho-hannover.de
authors.forename: Christina
authors.initials: C
authors.lastname: Strube
authors.forename: Georg
authors.initials: G
authors.lastname: von Samson-Himmelstjerna
authors.forename: Thomas
authors.initials: T
authors.lastname: Schnieder
mesh_terms: D000818:Animals; D029742:Caenorhabditis elegans Proteins / Q000235:genetics*; D002417:Cattle; D019295:Computational Biology; D017931:DNA Primers; D018509:DNA, Helminth / Q000032:analysis; D004021:Dictyocaulus / Q000235:genetics / Q000254:growth & development* / Q000378:metabolism; D005260:Female; D005786:Gene Expression Regulation; D049751:Genome, Helminth; D015801:Helminth Proteins / Q000235:genetics* / Q000378:metabolism; D008297:Male; D008969:Molecular Sequence Data; D019869:Phosphatidylinositol 3-Kinases / Q000235:genetics*; D016133:Polymerase Chain Reaction / Q000379:methods; D017422:Sequence Analysis, DNA; D015398:Signal Transduction
chemical_list: D029742:Caenorhabditis elegans Proteins; D017931:DNA Primers; D018509:DNA, Helminth; D015801:Helminth Proteins; D019869:Phosphatidylinositol 3-Kinases; C100662:AGE-1 protein, C elegans