Revisions to the staging and classification of mycosis fungoides and Sezary syndrome: a proposal of the International Society for Cutaneous Lymphomas (ISCL) and the cutaneous lymphoma task force of the European Organization of Research and Treatment of Cancer (EORTC).
The ISCL/EORTC recommends revisions to the Mycosis Fungoides Cooperative Group classification and staging system for cutaneous T-cell lymphoma (CTCL). These revisions are made to incorporate advances related to tumor cell biology and diagnostic techniques as pertains to mycosis fungoides (MF) and Sézary syndrome (SS) since the 1979 publication of the original guidelines, to clarify certain variables that currently impede effective interinstitution and interinvestigator communication and/or the development of standardized clinical trials in MF and SS, and to provide a platform for tracking other variables of potential prognostic significance. Moreover, given the difference in prognosis and clinical characteristics of the non-MF/non-SS subtypes of cutaneous lymphoma, this revision pertains specifically to MF and SS. The evidence supporting the revisions is discussed as well as recommendations for evaluation and staging procedures based on these revisions.
Olsen
Elise
E
Department of Medicine, Divisions of Dermatology and Oncology, Duke University Medical Center, Durham, NC 27516, USA. olsen001@mc.duke.edu
Vonderheid
Eric
E
Pimpinelli
Nicola
N
Willemze
Rein
R
Kim
Youn
Y
Knobler
Robert
R
Zackheim
Herschel
H
Duvic
Madeleine
M
Estrach
Teresa
T
Lamberg
Stanford
S
Wood
Gary
G
Dummer
Reinhard
R
Ranki
Annamari
A
Burg
Gunter
G
Heald
Peter
P
Pittelkow
Mark
M
Bernengo
Maria-Grazia
MG
Sterry
Wolfram
W
Laroche
Liliane
L
Trautinger
Franz
F
Whittaker
Sean
S
D005060:Europe; D006801:Humans; D009182:Mycosis Fungoides / Q000145:classification* / Q000473:pathology; D009367:Neoplasm Staging; D012751:Sezary Syndrome / Q000145:classification* / Q000473:pathology; D012878:Skin Neoplasms / Q000145:classification* / Q000473:pathology*; D012955:Societies, Medical