Comparison between textured silicone implants and those bonded with expanded polytetrafluoroethylene in rats.
OBJECTIVE
Comparison of the inflammatory reaction promoted by textured silicone implants and that caused by the implant bonded with e-ptfe.


METHODS
One-hundred and fifty rats were divided into three equal groups (control, silicone, and bonded e-ptfe). These groups were subdivided into five groups, according to the second operation, i.e., 7,30,60,90 and 180 days. Histology of the peri-implant tissue was analyzed by morphometry with blood count (neutrophils, lymphocytes, macrophages, fibroblasts and capillaries).


RESULTS
Comparison of subgroups 7,30,60,90, 180 days: - neutrophils: silicone: > in subgroup 7 days; bonded e-ptfe: > in subgroups 7 and 30 days; - lymphocytes: silicone: > in subgroup 7 and 180 days; bonded e-ptfe: > in subgroup 180 days; - macrophages: silicone: > in subgroup 7 and 60 days; bonded e-ptfe: > in subgroup 7,30 and 60 days; - fibroblasts: silicone: > in subgroup 30 and 60 days;- vascular volume: silicone: in subgroup 7, 60 and 90 days; bonded e-ptfe: > in subgroup 7 days. Comparison of groups: neutrophils : 7 days: > in silicone and bonded e-ptfe; 30 days: > in bonded e-ptfe; - lymphocytes: - 7,30,90 and 180 days: in the control; macrophages: - 7,30 and 60 days: > in silicone & bonded e-ptfe; 180 days > in silicone; fibroblasts: - 7,30 and 90 days: > in silicone and bonded e-ptfe; 180 days: > in bonded e-ptfe; vascular volume 7,60,90 and 180 days: > in silicone and bonded e-ptfe; 30 days: > in bonded e-ptfe.


CONCLUSIONS
The acute stage of the inflammatory response was more severe and irregular in the silicone implant; both the silicone implant and the silicone bonded with e-ptfe promoted chronic inflammatory reaction and weak foreign body inflammatory response. These reactions were greater in the silicone implant group.
Haddad Filho
Douglas
D
Division of Plastic Surgery, UNISA, São Paulo, Brazil.
Zveibel
Deborah K
DK
Alonso
Nivaldo
N
Gemperli
Rolf
R
D000818:Animals; D001672:Biocompatible Materials; D002196:Capillaries; D003094:Collagen; D005260:Female; D005347:Fibroblasts / Q000737:chemistry; D005549:Foreign-Body Reaction / Q000473:pathology*; D008264:Macrophages / Q000737:chemistry; D008422:Materials Testing; D011138:Polytetrafluoroethylene / Q000737:chemistry; D019736:Prostheses and Implants; D051381:Rats; D012826:Silicone Elastomers / Q000737:chemistry; D020034:Silicone Gels / Q000737:chemistry; D012828:Silicones
D001672:Biocompatible Materials; D012826:Silicone Elastomers; D020034:Silicone Gels; D012828:Silicones; D011138:Polytetrafluoroethylene; D003094:Collagen