Glycotoxins in the diet promote diabetes and diabetic complications.
Oxidant stress underlies diabetes and diabetic complications, including cardiovascular, renal, and retinal disease. Advanced glycation end products (AGEs), or glycotoxins, are a significant contributor to oxidant stress in diabetes. The diet is a major, unrecognized source of AGEs. Importantly, reduction of dietary AGEs decreases circulating inflammatory markers in both diabetic patients and prediabetic patients and complications in animal models. This beneficial outcome requires only a 50% decrease in dietary AGEs, making this necessary intervention practical and inexpensive.
Vlassara
Helen
H
Division of Experimental Diabetes and Aging, Department of Geriatrics, Mount Sinai School of Medicine, Box 1640, One Gustave Levy Place, New York, NY 10029, USA. helen.vlassara@mssm.edu
Striker
Gary
G
D000818:Animals; D048909:Diabetes Complications / Q000378:metabolism*; D003920:Diabetes Mellitus / Q000378:metabolism*; D004032:Diet; D017127:Glycation End Products, Advanced / Q000378:metabolism*; D006801:Humans; D018384:Oxidative Stress
D017127:Glycation End Products, Advanced