A simple method for detection of major phenotypic abnormalities in myelodysplastic syndromes: expression of CD56 in CMML.
Using a very simple flow cytometry protocol, we found that CD36 and CD117 on granulocytes and CD56 on monocytes were the major bone marrow phenotypic aberrations in patients with myelodysplasia, including CMML. CD56 on monocytes was associated with CMML. Importantly, phenotypic aberrations were lost on blood cells, except for CD56.
Lacronique-Gazaille
Charlotte
C
Chaury
Marie-Pierre
MP
Le Guyader
Alexandre
A
Faucher
Jean-Luc
JL
Bordessoule
Dominique
D
Feuillard
Jean
J
D019002:CD56 Antigen / Q000032:analysis*; D005434:Flow Cytometry / Q000379:methods; D006801:Humans; D016130:Immunophenotyping / Q000379:methods; D015477:Leukemia, Myelomonocytic, Chronic / Q000175:diagnosis*; D008722:Methods; D009000:Monocytes / Q000737:chemistry / Q000276:immunology; D009190:Myelodysplastic Syndromes / Q000175:diagnosis
D019002:CD56 Antigen