Recent advances in eosinophil biology.
Eosinophils are pleiotropic multi-functional leukocytes involved in initiation and propagation of diverse inflammatory responses. Recent studies examining eosinophil biology have focused on delineating the molecular basis of FIP1L1/PDGRFalpha-fusion gene induced HES, the molecular steps involved in eosinophil recruitment in tumor-associated eosinophilia and EGID, and the role of eosinophils in asthma. In this review, these studies are summarized, focusing on the implications of these findings in the understanding the role of eosinophils in diseases.
Hogan
Simon P
SP
Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA. simon.hogan@cchmc.org
D000818:Animals; D017951:Antigen Presentation; D001249:Asthma / Q000276:immunology / Q000503:physiopathology; D054413:Chemokine CCL11; D019742:Chemokines, CC / Q000502:physiology; D002634:Chemotaxis, Leukocyte / Q000502:physiology; D016207:Cytokines / Q000378:metabolism / Q000502:physiology; D004195:Disease Models, Animal; D047091:Eosinophil Granule Proteins / Q000502:physiology; D004802:Eosinophilia / Q000209:etiology; D004804:Eosinophils / Q000276:immunology / Q000502:physiology*; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000235:genetics / Q000503:physiopathology; D007249:Inflammation / Q000097:blood / Q000209:etiology / Q000276:immunology; D018836:Inflammation Mediators / Q000502:physiology; D007411:Intestinal Diseases, Parasitic / Q000276:immunology / Q000473:pathology; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000097:blood / Q000150:complications; D051379:Mice; D018345:Mice, Knockout; D008822:Mice, Transgenic; D009369:Neoplasms / Q000097:blood / Q000150:complications; D015514:Oncogene Proteins, Fusion / Q000502:physiology; D011828:Radiation Chimera; D020796:Receptor, Platelet-Derived Growth Factor alpha / Q000502:physiology; D039221:mRNA Cleavage and Polyadenylation Factors / Q000502:physiology
C515456:CCL11 protein, human; C515457:Ccl11 protein, mouse; D054413:Chemokine CCL11; D019742:Chemokines, CC; D016207:Cytokines; D047091:Eosinophil Granule Proteins; D018836:Inflammation Mediators; D015514:Oncogene Proteins, Fusion; D039221:mRNA Cleavage and Polyadenylation Factors; C479819:FIP1L1-PDGFRA fusion protein, human; D020796:Receptor, Platelet-Derived Growth Factor alpha