title: Analysis of histopathological and immunohistochemical differences of oral squamous cell carcinoma in young and old patients in Sri Lanka.
abstract: BACKGROUND
  Oral squamous cell carcinoma (OSCC) most commonly occurs in the middle-aged and older individuals. The purpose of the present study was to evaluate the histopathological and immunohistochemical differences of the younger (<40 years) and the older (more than 50 years) groups.
  
  
  METHODS
  The histopathological parameters of 112 patients (younger 56 and older 56) were compared according to three grading systems (Broder JAMA 1920; 74: 656, Anneroth et al. Scand J Dent Res 1987; 95: 229, Bryne et al. J Pathol 1992; 166: 375) and as individual histopathological parameters. Further, the expression of p53 and Proliferative Cell Nuclear Antigen (PCNA) index was also compared.
  
  
  RESULTS
  Although there was no significant difference between two groups regarding the three grading systems, a significantly higher number of nuclear aberrations was found in younger group (P<0.001). Interestingly, higher number of mitoses (P<0.05) and lymph node metastasis (P<0.05) were observed in the older group (P<0.05). Furthermore, significantly a higher PCNA index was found in the older group (P<0.005).
  
  
  CONCLUSIONS
  Although tumours of the young patients showed more nuclear aberrations, OSCC of the older patients is proliferative and showed higher metastatic rate.
authors.affiliation: Department of Oral and Maxillofacial Pathobiology, Division of Frontier Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan. samadarani@yahoo.com
authors.forename: B S M S
authors.initials: BS
authors.lastname: Siriwardena
authors.forename: A
authors.initials: A
authors.lastname: Tilakaratne
authors.forename: E A P D
authors.initials: EA
authors.lastname: Amaratunga
authors.forename: M N G P K
authors.initials: MN
authors.lastname: Udagama
authors.forename: Ikuko
authors.initials: I
authors.lastname: Ogawa
authors.forename: Yasusei
authors.initials: Y
authors.lastname: Kudo
authors.forename: Takashi
authors.initials: T
authors.lastname: Takata
authors.forename: W M
authors.initials: WM
authors.lastname: Tilakaratne
mesh_terms: D000328:Adult; D000367:Age Factors; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology* / Q000556:secondary; D016009:Chi-Square Distribution; D006801:Humans; D008207:Lymphatic Metastasis; D008875:Middle Aged; D008938:Mitosis; D009062:Mouth Neoplasms / Q000378:metabolism* / Q000473:pathology*; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism; D013188:Sri Lanka; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
chemical_list: D018809:Proliferating Cell Nuclear Antigen; D016159:Tumor Suppressor Protein p53