Low immune activation despite high levels of pathogenic human immunodeficiency virus type 1 results in long-term asymptomatic disease.
Long-term asymptomatic human immunodeficiency virus (HIV)-infected individuals (LTA) usually have low viral load and low immune activation. To discern whether viral load or immune activation is dominant in determining progression to AIDS, we studied three exceptional LTA with high viral loads. HIV type 1 isolates from these LTA were as pathogenic as viruses from progressors in organ culture. Despite high viral loads, these LTA had low levels of proliferating and activated T cells compared to progressors, like other LTA. In contrast to those in progressors, HIV-specific CD4(+) T-cell responses in these LTA were maintained. Thus, low immune activation despite a high viral load preserved HIV-specific T-cell responses and resulted in a long-term asymptomatic phenotype.
Choudhary
Shailesh K
SK
Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697-3900, USA.
Vrisekoop
Nienke
N
Jansen
Christine A
CA
Otto
Sigrid A
SA
Schuitemaker
Hanneke
H
Miedema
Frank
F
Camerini
David
D
D000163:Acquired Immunodeficiency Syndrome / Q000175:diagnosis* / Q000276:immunology*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D015497:HIV-1 / Q000276:immunology* / Q000302:isolation & purification*; D006801:Humans; D008213:Lymphocyte Activation; D019562:Viral Load