title: Polymorphisms in interleukin-15 gene on chromosome 4q31.2 are associated with psoriasis vulgaris in Chinese population.
abstract: Through a series of linkage analyses in a large Chinese family cohort of psoriasis, we previously identified and confirmed a non-HLA psoriasis linkage locus PSORS9 within a small region at 4q31.2-32.1. Within the critical region of the PSORS9 locus, IL-15 has been long recognized as a strong candidate gene for psoriasis. In this study, we investigated the association between IL-15 genetic polymorphisms and psoriasis in a large Chinese sample. Highly significant evidence for association was identified at a single-nucleotide polymorphism (SNP) (g.96516A --> T) within the 3'-untranslated region (UTR) of the IL-15 gene (P=0.00006, after correction for multiple testing). Haplotype analysis using the SNPs within the 3'UTR region also provided strong supporting evidence for association (P=0.00005), where we identified a haplotype of the 3'UTR region of IL-15 associated with increased risk to psoriasis (odds ratio=1.65). This association was also supported by the results of our expression activity analyses, where we demonstrated that the identified risk haplotype is associated with an increased activity of IL-15. Therefore, we provided early evidence for the important role of IL-15 genetic variants in the pathogenesis of psoriasis, probably by increasing interleukin production and inflammation in the lesions of psoriasis.
authors.affiliation: Institute of Dermatology and Department of Dermatology at No.1 Hospital, Anhui Medical University, Hefei, China. ayzxj@vip.sina.com
authors.forename: Xue-Jun
authors.initials: XJ
authors.lastname: Zhang
authors.forename: Kai-Lin
authors.initials: KL
authors.lastname: Yan
authors.forename: Zhi-Min
authors.initials: ZM
authors.lastname: Wang
authors.forename: Sen
authors.initials: S
authors.lastname: Yang
authors.forename: Guo-Long
authors.initials: GL
authors.lastname: Zhang
authors.forename: Xing
authors.initials: X
authors.lastname: Fan
authors.forename: Feng-Li
authors.initials: FL
authors.lastname: Xiao
authors.forename: Min
authors.initials: M
authors.lastname: Gao
authors.forename: Yong
authors.initials: Y
authors.lastname: Cui
authors.forename: Pei-Guang
authors.initials: PG
authors.lastname: Wang
authors.forename: Liang-dan
authors.initials: LD
authors.lastname: Sun
authors.forename: Kai-Yue
authors.initials: KY
authors.lastname: Zhang
authors.forename: Beilan
authors.initials: B
authors.lastname: Wang
authors.forename: Da-Zhi
authors.initials: DZ
authors.lastname: Wang
authors.forename: Shi-Jie
authors.initials: SJ
authors.lastname: Xu
authors.forename: Wei
authors.initials: W
authors.lastname: Huang
authors.forename: Jian-Jun
authors.initials: JJ
authors.lastname: Liu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D002681:China; D002894:Chromosomes, Human, Pair 4 / Q000235:genetics*; D015331:Cohort Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D019409:Interleukin-15 / Q000235:genetics* / Q000378:metabolism; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011565:Psoriasis / Q000208:ethnology / Q000235:genetics* / Q000378:metabolism
chemical_list: D019409:Interleukin-15