Role of mast cells and basophils in chronic rhinosinusitis.
Mast cells and basophils contribute to induction and/or maintenance of eosinophilic inflammation by a variety of mechanisms, including IgE-dependent and IgE-independent processes. The latter include a variety of stimuli that have only recently been elucidated, including mechanisms triggered by bacteria, virus, fungi, complement, or autoantibodies. MCs, and basophils contribute to inflammation both directly through the release of inflammatory mediators, cytokines and growth factors and indirectly through the activation of structural cells. Accumulating evidence places MCs (and most probably basophils) in a position of importance in the pathogenesis of CRS, particularly in the pathogenesis and progression of NP (Fig. 1). Mechanisms other than conventional IgE-dependent activation of MCs are intriguing as potential mechanisms of eosinophilic inflammation in non-allergic CRS/NP. Although it is not possible using current pharmacologic approaches to completely isolate the effects of MCs or basophils in CRS and NP pathogenesis, it seems most likely that such approaches will eventually be available. It might be expected that one or both of these cells will be shown to play important roles, particularly considering their potential for activation by IgE and non-IgE mechanisms, their production of a broad array of inflammatory mediators, cytokines and growth factors, and their unique assortment of proteases.
Pawankar
Ruby
R
Department of Otolaryngology, Nippon Medical School, Tokyo, Japan.
Lee
Kun Hee
KH
Nonaka
Manabu
M
Takizawa
Ryuta
R
D000818:Animals; D001249:Asthma / Q000209:etiology / Q000276:immunology; D001491:Basophils / Q000502:physiology*; D002908:Chronic Disease; D006801:Humans; D008407:Mast Cells / Q000502:physiology*; D009298:Nasal Polyps / Q000209:etiology* / Q000276:immunology; D012220:Rhinitis / Q000209:etiology* / Q000276:immunology; D012852:Sinusitis / Q000209:etiology* / Q000276:immunology