title: Synthesis and antimicrobial activities of isomers of N(4),N(11)-dimethyl-3,5,7,7,10,12,14,14-octamethyl-1,4,8,11-tetraazacyclotetradecane and their nickel(II) complexes.
abstract: The reactions of two isomers of 3,5,7,7,10,12,14,14-octamethyl-1,4,8,11-tetraazacyclotetradecane (differing in the orientation of the methyl groups on the chiral carbon atoms), designated as L(B) and L(C), with CH(3)I in the ratio of 1:4 resulted in the substitution of the N(4) and N(11) protons by CH(3) groups, forming the dimethyl derivatives L(BZ) and L(CZ), respectively. These ligands, on interaction with nickel(II) acetate tetrahydrate and subsequent addition of lithium perchlorate, produce square-planar yellow [NiL(BZ)][ClO(4)](2) and orange [NiL(C'Z)][ClO(4)](2). These nickel complexes undergo axial ligand addition reactions with NCS(-), Cl(-), Br(-), and I(-) as X(-) to form six-coordinate trans-diisothiocyanato, -dichloro, -dibromo, and -diiodo complexes of formula [NiLX(2)], where L = L(BZ) or L(C'Z), and X = SCN, Cl, Br, or I. All these compounds have been characterized on the basis of analytical, spectroscopic, conductometric, and magnetochemical data. The structures of L(BZ) and two variants of [Ni"L(BZ)"][ClO(4)](2) (crystallizing in the space group P2(1)/n and Pn, respectively; "L(BZ)" symbolizes partially methylated ligand) have been determined by single-crystal X-ray analyses. The antifungal and antibacterial activities of these compounds have been studied against some phytopathogenic fungi and bacteria.
authors.affiliation: Department of Chemistry, University of Chittagong, Chittagong-4331, Bangladesh. tapashir@yahoo.com
authors.forename: Tapashi G
authors.initials: TG
authors.lastname: Roy
authors.forename: Saroj K S
authors.initials: SK
authors.lastname: Hazari
authors.forename: Benu K
authors.initials: BK
authors.lastname: Dey
authors.forename: Hazarat A
authors.initials: HA
authors.lastname: Miah
authors.forename: Falk
authors.initials: F
authors.lastname: Olbrich
authors.forename: Dieter
authors.initials: D
authors.lastname: Rehder
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D018360:Crystallography, X-Ray; D004563:Electrochemistry; D005658:Fungi / Q000187:drug effects; D006573:Heterocyclic Compounds, 1-Ring / Q000138:chemical synthesis* / Q000494:pharmacology; D007536:Isomerism; D008024:Ligands; D015394:Molecular Structure; D009532:Nickel / Q000737:chemistry*; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013057:Spectrum Analysis
chemical_list: D000890:Anti-Infective Agents; D006573:Heterocyclic Compounds, 1-Ring; D008024:Ligands; D009942:Organometallic Compounds; D009532:Nickel