Complete ascertainment of Parkinson disease in the Swedish Twin Registry.
This report describes the ascertainment of Parkinson disease (PD) in all individuals aged 50 years or older (49,814 individuals) from the Swedish Twin Registry. In phase one of the study, all twins were screened for PD using telephone interviews, with a response rate of 72.7%. In phase two, twins with suspected PD were re-contacted to exclude anyone from follow-up who reported parkinsonian symptoms due to diseases other than PD. In the third phase, in-person clinical evaluations were completed for twins who were still considered PD suspects after phase two and for a sample of co-twins. During the clinical evaluations, we also collected blood samples and information about a variety of environmental exposures. Overall prevalence rate for PD was 496 per 100,000 individuals. Among the 132 PD cases identified, there were only three concordant twin pairs. In total 7.2% of PD cases reported a first degree relative with PD.
Wirdefeldt
Karin
K
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. karin.wirdefeldt@ki.se
Gatz
Margaret
M
Bakaysa
Stephanie L
SL
Fiske
Amy
A
Flensburg
Måns
M
Petzinger
Giselle M
GM
Widner
Håkan
H
Lew
Mark F
MF
Welsh
Mickie
M
Pedersen
Nancy L
NL
D004200:Diseases in Twins / Q000175:diagnosis* / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000175:diagnosis* / Q000453:epidemiology*; D015995:Prevalence; D012042:Registries; D013548:Sweden / Q000453:epidemiology; D014427:Twins