A new gamma-polymorph of chlorpropamide: 4-chloro-N-(propylaminocarbonyl)benzenesulfonamide.
The structure of a new polymorph of the title compound, C(10)H(13)ClN(2)O(3)S, known as the antidiabetic drug chlorpropamide, is monoclinic, in contrast with the two previously described orthorhombic alpha- and beta-forms. The molecules in the gamma-polymorph are linked into bands by hydrogen bonds similar to those in the alpha-polymorph. The conformation of the molecules in the gamma-form is close to that in the beta-polymorph.
Drebushchak
Tatiana N
TN
Institute of Solid State Chemistry and Mechanochemistry, Siberian Branch of the Russian Academy of Sciences, Kutateladze 18, Novosibirsk 128, 630128 Russian Federation. tanya@xray.nsu.ru
Chukanov
Nikita V
NV
Boldyreva
Elena V
EV
D002747:Chlorpropamide / Q000737:chemistry*; D018360:Crystallography, X-Ray; D007536:Isomerism; D008968:Molecular Conformation; D011437:Propylamines / Q000737:chemistry*; D013449:Sulfonamides / Q000737:chemistry*; D000096926:Benzenesulfonamides
D002747:Chlorpropamide; D011437:Propylamines; D013449:Sulfonamides; C522878:4-chloro-N-(propylaminocarbonyl)benzenesulfonamide; D000096926:Benzenesulfonamides