title: Mixed Langmuir monolayers of gramicidin A and fluorinated alcohols.
abstract: Mixed monolayers of gramicidin A (GA) and three alcohols, differing in the degree of fluorination, namely C18OH, F18OH, and F8H10OH have been investigated by means of: surface manometry (pi-A isotherms) and Brewster angle microscopy (BAM) aiming at finding appropriate molecules for incorporating gramicidin A for a biosensor design. Our results proved that only the semifluorinated alcohol is appropriate material for this purpose since it forms miscible and homogeneous monolayers with GA within the whole concentration range. The experimental results have been supported by the calculations of van der Waals energy profiles using the Insight II program. Both the hydrogenated and perfluorinated alcohols were found to aggregate at higher surface pressures, which exclude their application for gramicidin-based biosensor construction.
authors.affiliation: Faculty of Chemistry, Jagiellonian University, Ingardena 3, 30-060 Kraków, Poland. broniato@chemia.uj.edu.pl
authors.forename: Marcin
authors.initials: M
authors.lastname: Broniatowski
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Obidowicz
authors.forename: Nuria
authors.initials: N
authors.lastname: Vila Romeu
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Broniatowska
authors.forename: Patrycja
authors.initials: P
authors.lastname: Dynarowicz-Łatka
mesh_terms: D015374:Biosensing Techniques; D005233:Fatty Alcohols / Q000737:chemistry*; D006096:Gramicidin / Q000737:chemistry*; D006845:Hydrocarbons, Fluorinated / Q000737:chemistry*; D008567:Membranes, Artificial; D008956:Models, Chemical; D012984:Software; D013500:Surface Tension
chemical_list: D005233:Fatty Alcohols; D006845:Hydrocarbons, Fluorinated; D008567:Membranes, Artificial; D006096:Gramicidin