Chemokines and their receptors in respiratory disease: a therapeutic target for respiratory syncytial virus infection.
Cell recruitment is a multistep process orchestrated by chemokines and their receptors. The chemokine/receptor system is central to many inflammatory diseases, making it a key target for therapeutic intervention. Despite complexity and redundancy within the system, effective antagonists are in development and undergoing clinical trials, for example, maraviroc, for use in HIV treatment. Respiratory syncytial virus (RSV) is a major cause of lower respiratory tract infection in infants, with global annual infection estimated at 64 million people. Current treatment is purely supportive, with no effective vaccine available. RSV pathology is partly due to excessive airway inflammation. Evidence is growing for a key role for chemokine receptors. Receptor blockade may therefore provide a feasible therapeutic option to inhibit RSV-induced inflammation and thereby reduce disease severity.
Thomas
Lynette H
LH
Department of Infectious Diseases & Immunity, Imperial College, London, UK. lynthomas01@yahoo.co.uk
Friedland
Jon S
JS
Sharland
Mike
M
D018925:Chemokines / Q000037:antagonists & inhibitors*; D006801:Humans; D008024:Ligands; D018448:Models, Immunological; D019707:Receptors, Chemokine / Q000037:antagonists & inhibitors*; D018357:Respiratory Syncytial Virus Infections / Q000188:drug therapy* / Q000453:epidemiology / Q000276:immunology; D015398:Signal Transduction
D018925:Chemokines; D008024:Ligands; D019707:Receptors, Chemokine