title: Brooke-Spiegler syndrome - report of four families: treatment with CO2 laser.
abstract: BACKGROUND
  Brooke-Spiegler syndrome is a well known but rare cutaneous disorder characterized by the presence of multiple trichoepitheliomas and cylindromas.
  
  
  METHODS
  Four families with Brooke-Spiegler syndrome are described.
  
  
  RESULTS
  Spiradenomas developed on the back in two patients. A CO(2) laser was used to treat facial trichoepitheliomas in two patients with good results.
  
  
  CONCLUSIONS
  The large number of facial lesions in this syndrome often produce a significant emotional impact. We believe that it is important to provide patients with a good therapeutic option. CO(2) laser therapy may fill this role.
authors.affiliation: Department of Dermatology, Hospital Cosme Argerich and CHOUELA DERMATOLOGIA Center, Buenos Aires, Argentina. aretamar@intramed.net.ar
authors.forename: Roberto Adrián
authors.initials: RA
authors.lastname: Retamar
authors.forename: F
authors.initials: F
authors.lastname: Stengel
authors.forename: M E
authors.initials: ME
authors.lastname: Saadi
authors.forename: M C
authors.initials: MC
authors.lastname: Kien
authors.forename: P
authors.initials: P
authors.lastname: Della Giovana
authors.forename: H
authors.initials: H
authors.lastname: Cabrera
authors.forename: E N
authors.initials: EN
authors.lastname: Chouela
mesh_terms: D006607:Adenoma, Sweat Gland / Q000473:pathology / Q000601:surgery*; D000328:Adult; D000368:Aged; D003528:Carcinoma, Adenoid Cystic / Q000473:pathology / Q000601:surgery*; D002648:Child; D005145:Face / Q000473:pathology; D005260:Female; D006801:Humans; D053685:Laser Therapy; D008297:Male; D008875:Middle Aged; D018294:Neoplasms, Adnexal and Skin Appendage / Q000473:pathology / Q000601:surgery*; D009378:Neoplasms, Multiple Primary / Q000473:pathology / Q000601:surgery*; D009386:Neoplastic Syndromes, Hereditary / Q000473:pathology / Q000601:surgery*; D012535:Scalp / Q000473:pathology; D012878:Skin Neoplasms / Q000473:pathology / Q000601:surgery*