Cell therapy in kidney disease: cautious optimism... but optimism nonetheless.
The recently discovered therapeutic potential of stem or progenitor cells has initiated development of novel treatments in a number of diseases-treatments that could not only improve patients' quality of life, but also halt or even prevent disease progression. Hypertension; fluctuations in glycemia, electrolytes, nutrient levels, and circulating volume; and frequent infections and the associated inflammation all greatly impair the endothelium in patients undergoing peritoneal dialysis. As our understanding of the regulatory function of the endothelium advances, focus is increasingly being placed on endothelial repair in acute and chronic renal failure and after renal transplantation. The potential of progenitor cells to repair damaged endothelium and to reduce inflammation in patients with renal failure remains unexamined; however, a successful cell therapy could reduce morbidity and mortality in kidney disease. Important contributions have been made in identifying progenitor cell populations in the kidney, and further investigations into the relationships of these cells with the pathophysiology of the disease are underway. As the kidney disease field prepares for the first human trials of progenitor cell therapies, we deemed it important to review representative original research, and to share our perspectives and lessons learned from clinical trials of progenitor cell-based therapies that have commenced in patients with cardiovascular disease.
Zenovich
Andrey G
AG
Center for Cardiovascular Repair, and Department of Medicine and Center for Cardiovascular Repair, University of Minnesota, Minneapolis, Minnesota 55455, USA.
Taylor
Doris A
DA
D002318:Cardiovascular Diseases / Q000209:etiology / Q000628:therapy; D002986:Clinical Trials as Topic; D018450:Disease Progression; D004847:Epithelial Cells / Q000502:physiology; D006801:Humans; D007249:Inflammation; D007668:Kidney / Q000166:cytology; D016030:Kidney Transplantation; D010530:Peritoneal Dialysis; D011788:Quality of Life; D051437:Renal Insufficiency / Q000150:complications / Q000628:therapy*; D033581:Stem Cell Transplantation / Q000379:methods*; D013234:Stem Cells / Q000502:physiology*