title: Cytotoxic alpha-pyrones from Xylaria hypoxylon.
abstract: Two new alpha-pyrone derivatives, xylarone (1) and 8,9-dehydroxylarone (2) possessing cytotoxic activities, were isolated from the culture fluid of submerged cultures of the ascomycete Xylaria hypoxylon, strain A27-94. Their structures were elucidated by spectroscopic methods.
authors.affiliation: Institute of Biotechnology and Drug Research, Erwin-Schrödinger-Str. 56, D-67663 Kaiserslautern, Germany.
authors.forename: Anja
authors.initials: A
authors.lastname: Schüffler
authors.forename: Olov
authors.initials: O
authors.lastname: Sterner
authors.forename: Heidrun
authors.initials: H
authors.lastname: Anke
mesh_terms: D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D007939:Leukemia L1210 / Q000473:pathology; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D011753:Pyrones / Q000737:chemistry / Q000302:isolation & purification* / Q000633:toxicity*; D013055:Spectrophotometry, Infrared; D013098:Xylariales / Q000737:chemistry*
chemical_list: D011753:Pyrones