title: Resolution of acromegalic cardiomyopathy in mild acromegalic physical abnormality after short-term octreotide therapy.
abstract: Congestive heart failure developed in a 42-year-old man who had very mild acromegalic features. Echocardiography showed a marked dilatation of the left ventricle and decreased systolic function. Laboratory examinations revealed the elevated levels of growth hormone and insulin-like growth factor-1 and pituitary microadenoma was demonstrated by magnetic resonance imaging. Although the extensive conventional medical treatment was ineffective, short-term addition of somatostatin analog, octreotide, rapidly improved his cardiac function. After discontinuation of octreotide, further improvement was observed with minimal residual diastolic dysfunction. All medical treatment could be stopped after successful trans-sphenoidal surgery. Early diagnosis and effective treatment is important to reverse the acromegalic cardiomyopathy.
authors.affiliation: Department of Cardiovascular Medicine, Ijinkai-Takeda General Hospital, 28-1 Ishidamori, Minami-machi, Fushimi-ku, Kyoto, 601-1495, Japan.
authors.forename: Myung-Woo
authors.initials: MW
authors.lastname: Hwang
authors.forename: Akira
authors.initials: A
authors.lastname: Shimatsu
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Sasaki
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Ayukawa
authors.forename: Katsura
authors.initials: K
authors.lastname: Inenaga
authors.forename: Rei
authors.initials: R
authors.lastname: Takeoka
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Iwase
authors.forename: Chuichi
authors.initials: C
authors.lastname: Kawai
mesh_terms: D000172:Acromegaly / Q000000981:diagnostic imaging / Q000188:drug therapy*; D004452:Echocardiography; D004562:Electrocardiography; D006333:Heart Failure / Q000000981:diagnostic imaging / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015282:Octreotide / Q000627:therapeutic use*; D011859:Radiography
chemical_list: D015282:Octreotide