title: The COL1A1 gene and high myopia susceptibility in Japanese.
abstract: The collagen type Iota alpha Iota (COL1A1) gene encodes the extracellular matrix component, collagen, and resides in candidate MYP5 for high myopia on the chromosome 17q22-q23.3. This locus has recently been implicated in playing an important role in the pathogenesis of experimental myopia. We investigated the association of disruptions of COL1A1 gene with high myopia by analyzing the frequency of ten SNPs in a Japanese population of 330 subjects with high myopia of -9.25 D or less and 330 randomized controls without high myopia. Two SNPs (rs2075555 and rs2269336) were significantly associated with high myopia (P < 0.05, Pc < 0.1). Two different haplotype blocks in COL1A1 were observed by the pair-wise linkage disequilibrium between the SNPs. The frequency of GGC/GGC diplotype constructed by the three SNPs (rs2075555, rs2269336, rs1107946) was significantly high (OR = 1.6) and associated with high myopia (P = 0.028, Pc< 0.084). Together our results provide the first evidence for COL1A1 as a gene associated with high myopia.
authors.affiliation: Department of Ophthalmology, Yokohama City University School of Medicine, Yokohama, Kanagawa, Japan.
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Inamori
authors.forename: Masao
authors.initials: M
authors.lastname: Ota
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Inoko
authors.forename: Eiichi
authors.initials: E
authors.lastname: Okada
authors.forename: Ritsuko
authors.initials: R
authors.lastname: Nishizaki
authors.forename: Tomoko
authors.initials: T
authors.lastname: Shiota
authors.forename: Jeewon
authors.initials: J
authors.lastname: Mok
authors.forename: Akira
authors.initials: A
authors.lastname: Oka
authors.forename: Shigeaki
authors.initials: S
authors.lastname: Ohno
authors.forename: Nobuhisa
authors.initials: N
authors.lastname: Mizuki
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics*; D001483:Base Sequence; D002886:Chromosomes, Human, Pair 17 / Q000235:genetics*; D024042:Collagen Type I / Q000235:genetics*; D000090602:Collagen Type I, alpha 1 Chain; D030541:Databases, Genetic; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D007564:Japan; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D009216:Myopia / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D017422:Sequence Analysis, DNA
chemical_list: D024042:Collagen Type I; D000090602:Collagen Type I, alpha 1 Chain