title: The use of mixed-mode ion-exchange solid phase extraction to characterize pharmaceutical drug degradation.
abstract: Solid phase extraction (SPE) has been utilized extensively in the pharmaceutical industry for the isolation of pharmaceuticals from interfering biological matrices and the purification and concentration of impurities and degradation products present in analytical samples. The work described herein involves the novel use of mixed-mode ion-exchange solid phase extraction to characterize degradation products of several pharmaceutical drugs, thereby giving important clues to their structure and sites of reactivity. Several examples of the use of mixed-mode ion-exchange solid phase extraction to illustrate the utility of this technique are presented.
authors.affiliation: Pfizer Global Research and Development, Pharmaceutical Sciences Division, Eastern Point Road MC 4127, Groton, CT 06340, USA. margaret.s.landis@pfizer.com
authors.forename: Margaret S
authors.initials: MS
authors.lastname: Landis
mesh_terms: D002021:Buffers; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D002852:Chromatography, Ion Exchange / Q000379:methods*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010084:Oxidation-Reduction; D004364:Pharmaceutical Preparations / Q000032:analysis* / Q000737:chemistry / Q000302:isolation & purification; D012015:Reference Standards; D012965:Sodium Chloride / Q000737:chemistry; D052616:Solid Phase Extraction / Q000379:methods*; D012996:Solutions / Q000737:chemistry; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D013696:Temperature
chemical_list: D002021:Buffers; D004364:Pharmaceutical Preparations; D012996:Solutions; D012965:Sodium Chloride