[Effects of ischemia on olfactory bulb in rats].
OBJECTIVE
To observe the olfactory bulb's morphological change after ischemic injury in rats, and explore the role of vascular factor in olfactory disorders.


METHODS
Forty adult SD rats (weighting 250-300 g) were used, 30 of which were treated with permanent bilateral occlusion of both common carotid arteries, and the others were served as the control. The olfactory bulbs were carefully taken out on the 1st week, 4th week, 2nd month post operation, respectively, then observed the morphological changes by light microscopy. The ultra structure of cells in olfactory bulbs were also observed by transmission electron microscope.


RESULTS
In rats with permanent bilateral occlusion of both common carotid arteries, the vascular pattern changed and the cell number decreased in olfactory bulbs by light microscopy. In the 1st week group, the mitral cells' mitochondria injury and metamorphism were found. In the 4th week group, the microvascular paramorphia, lipofuscin in mitral cells and metamorphic nerve fibers were found by transmission electron microscope.


CONCLUSIONS
Ischemia could injure the neuron and nerve fiber. This may be one of the reasons of olfactory disorders.
Zhan
Xiaojun
X
Department of Otolaryngology-Head and Neck Surgery, Beijing Tongren Hospital Affiliated to Capital University of Medical Sciences,Beijing, 100730, China.
Wei
Yongxiang
Y
Miao
Xutao
X
Zhang
Cong
C
Han
Demin
D
D000818:Animals; D007511:Ischemia / Q000473:pathology*; D046529:Microscopy, Electron, Transmission; D009474:Neurons / Q000473:pathology / Q000648:ultrastructure; D009830:Olfactory Bulb / Q000166:cytology* / Q000473:pathology*; D051381:Rats; D017207:Rats, Sprague-Dawley