CLASPing microtubules at the trans-Golgi network.
Microtubule (MT) arrays can be formed either from centrosomes or from noncentrosomal locations. In this issue of Developmental Cell, Efimov and colleagues report a role of CLASPs, the MT plus end-binding proteins, in MT formation from Golgi, implicating Golgi-originated MT arrays in efficient cell migration (Efimov et al., 2007).
Liu
Zhonghua
Z
Carnegie Institution of Washington and Howard Hughes Medical Institution, Department of Embryology, Baltimore, MD 21218, USA.
Vong
Queenie P
QP
Zheng
Yixian
Y
D018385:Centrosome / Q000378:metabolism; D006056:Golgi Apparatus / Q000502:physiology; D006367:HeLa Cells; D006801:Humans; D008869:Microtubule-Associated Proteins / Q000502:physiology*; D008870:Microtubules / Q000378:metabolism*; D014404:Tubulin / Q000378:metabolism; D021601:trans-Golgi Network / Q000502:physiology*
C497850:CLASP1 protein, human; C497851:CLASP2 protein, human; D008869:Microtubule-Associated Proteins; D014404:Tubulin