title: Comparison between textured silicone implants and those bonded with expanded polytetrafluoroethylene in rats.
abstract: OBJECTIVE
  Comparison of the inflammatory reaction promoted by textured silicone implants and that caused by the implant bonded with e-ptfe.
  
  
  METHODS
  One-hundred and fifty rats were divided into three equal groups (control, silicone, and bonded e-ptfe). These groups were subdivided into five groups, according to the second operation, i.e., 7,30,60,90 and 180 days. Histology of the peri-implant tissue was analyzed by morphometry with blood count (neutrophils, lymphocytes, macrophages, fibroblasts and capillaries).
  
  
  RESULTS
  Comparison of subgroups 7,30,60,90, 180 days: - neutrophils: silicone: > in subgroup 7 days; bonded e-ptfe: > in subgroups 7 and 30 days; - lymphocytes: silicone: > in subgroup 7 and 180 days; bonded e-ptfe: > in subgroup 180 days; - macrophages: silicone: > in subgroup 7 and 60 days; bonded e-ptfe: > in subgroup 7,30 and 60 days; - fibroblasts: silicone: > in subgroup 30 and 60 days;- vascular volume: silicone: in subgroup 7, 60 and 90 days; bonded e-ptfe: > in subgroup 7 days. Comparison of groups: neutrophils : 7 days: > in silicone and bonded e-ptfe; 30 days: > in bonded e-ptfe; - lymphocytes: - 7,30,90 and 180 days: in the control; macrophages: - 7,30 and 60 days: > in silicone & bonded e-ptfe; 180 days > in silicone; fibroblasts: - 7,30 and 90 days: > in silicone and bonded e-ptfe; 180 days: > in bonded e-ptfe; vascular volume 7,60,90 and 180 days: > in silicone and bonded e-ptfe; 30 days: > in bonded e-ptfe.
  
  
  CONCLUSIONS
  The acute stage of the inflammatory response was more severe and irregular in the silicone implant; both the silicone implant and the silicone bonded with e-ptfe promoted chronic inflammatory reaction and weak foreign body inflammatory response. These reactions were greater in the silicone implant group.
authors.affiliation: Division of Plastic Surgery, UNISA, São Paulo, Brazil.
authors.forename: Douglas
authors.initials: D
authors.lastname: Haddad Filho
authors.forename: Deborah K
authors.initials: DK
authors.lastname: Zveibel
authors.forename: Nivaldo
authors.initials: N
authors.lastname: Alonso
authors.forename: Rolf
authors.initials: R
authors.lastname: Gemperli
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D002196:Capillaries; D003094:Collagen; D005260:Female; D005347:Fibroblasts / Q000737:chemistry; D005549:Foreign-Body Reaction / Q000473:pathology*; D008264:Macrophages / Q000737:chemistry; D008422:Materials Testing; D011138:Polytetrafluoroethylene / Q000737:chemistry; D019736:Prostheses and Implants; D051381:Rats; D012826:Silicone Elastomers / Q000737:chemistry; D020034:Silicone Gels / Q000737:chemistry; D012828:Silicones
chemical_list: D001672:Biocompatible Materials; D012826:Silicone Elastomers; D020034:Silicone Gels; D012828:Silicones; D011138:Polytetrafluoroethylene; D003094:Collagen