Exploiting ligand conformation in selective inhibition of non-ribosomal peptide synthetase amino acid adenylation with designed macrocyclic small molecules.
Cisar
Justin S
JS
Tri-Institutional Training Program in Chemical Biology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, Box 422, New York, New York 10021, USA.
Ferreras
Julian A
JA
Soni
Rajesh K
RK
Quadri
Luis E N
LE
Tan
Derek S
DS
D000596:Amino Acids / Q000737:chemistry* / Q000378:metabolism*; D008024:Ligands; D047028:Macrocyclic Compounds / Q000737:chemistry* / Q000378:metabolism*; D015394:Molecular Structure; D010453:Peptide Synthases / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism; D017434:Protein Structure, Tertiary
D000596:Amino Acids; D008024:Ligands; D047028:Macrocyclic Compounds; D010453:Peptide Synthases