title: Mapping quantitative trait loci for osteochondrosis in fetlock and hock joints and palmar/plantar osseus fragments in fetlock joints of South German Coldblood horses.
abstract: The aim of this study was to identify quantitative trait loci (QTL) for osteochondrosis (OC) and palmar/plantar osseous fragments (POF) in fetlock joints in a whole-genome scan of 219 South German Coldblood horses. Symptoms of OC and POF were checked by radiography in 117 South German Coldblood horses at a mean age of 17 months. The radiographic examination comprised the fetlock and hock joints of all limbs. The genome scan included 157 polymorphic microsatellite markers. All microsatellite markers were equally spaced over the 31 autosomes and the X chromosome, with an average distance of 17.7 cM and a mean polymorphism information content (PIC) of 63%. Sixteen chromosomes harbouring putative QTL regions were further investigated by genotyping the animals with 93 additional markers. QTL that had chromosome-wide significance by non-parametric Z-means and LOD scores were found on 10 chromosomes. This included seven QTL for fetlock OC and one QTL on ECA18 associated with hock OC and fetlock OC. Significant QTL for POF in fetlock joints were located on equine chromosomes 1, 4, 8, 12 and 18. This genome scan is an important step towards the identification of genes responsible for OC in horses.
authors.affiliation: Institute for Animal Breeding and Genetics, University of Veterinary Medicine Hannover, Bünteweg 17p, 30559 Hannover, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Wittwer
authors.forename: K
authors.initials: K
authors.lastname: Löhring
authors.forename: C
authors.initials: C
authors.lastname: Drögemüller
authors.forename: H
authors.initials: H
authors.lastname: Hamann
authors.forename: E
authors.initials: E
authors.lastname: Rosenberger
authors.forename: O
authors.initials: O
authors.lastname: Distl
mesh_terms: D000818:Animals; D001175:Arthrography / Q000662:veterinary; D005260:Female; D005552:Forelimb; D005819:Genetic Markers; D016678:Genome; D005838:Genotype; D006614:Hindlimb; D006734:Horse Diseases / Q000000981:diagnostic imaging / Q000235:genetics*; D006736:Horses; D007596:Joints; D008297:Male; D010007:Osteochondritis / Q000000981:diagnostic imaging / Q000235:genetics / Q000662:veterinary*; D040641:Quantitative Trait Loci; D013643:Tarsus, Animal / Q000000981:diagnostic imaging; D050277:Toe Phalanges / Q000000981:diagnostic imaging
chemical_list: D005819:Genetic Markers