Systemic and central amygdala injections of the mGluR2/3 agonist LY379268 attenuate the expression of incubation of sucrose craving in rats.
We previously reported that systemic or central amygdala injections of the mGluR(2/3) agonist LY379268 (which decreases glutamate release) prevented enhanced cue-induced cocaine seeking in extinction tests after prolonged withdrawal (incubation of cocaine craving). Here, we report that systemic and central amygdala injections of LY379268 also prevented the enhanced cue-induced sucrose seeking in extinction tests after prolonged sucrose-free period (incubation of sucrose craving). These findings suggest that central amygdala glutamate plays an important role in the incubation of reward craving after withdrawal from both drug and non-drug rewards.
Uejima
Jamie L
JL
Neurobiology of Relapse Section, Intramural Research Program, National Institute on Drug Abuse, NIH, DHHS, Baltimore, MD 22124, USA.
Bossert
Jennifer M
JM
Poles
Gabriela C
GC
Lu
Lin
L
D000596:Amino Acids / Q000008:administration & dosage*; D000679:Amygdala / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D001070:Appetitive Behavior / Q000187:drug effects*; D001245:Association Learning / Q000502:physiology; D016739:Behavior, Addictive / Q000378:metabolism; D001522:Behavior, Animal / Q000187:drug effects*; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000008:administration & dosage*; D004333:Drug Administration Routes; D008297:Male; D008845:Microinjections; D051381:Rats; D020318:Rats, Long-Evans; D018094:Receptors, Metabotropic Glutamate / Q000819:agonists* / Q000378:metabolism; D012201:Reward; D012646:Self Administration; D013395:Sucrose / Q000008:administration & dosage
D000596:Amino Acids; D019086:Bridged Bicyclo Compounds, Heterocyclic; C118218:LY 379268; D018094:Receptors, Metabotropic Glutamate; D013395:Sucrose