title: Monitoring of adverse events during the 2003 mass vaccination campaign with a trivalent meningococcal A/C/W135 polysaccharide vaccine in Burkina Faso.
abstract: During a mass campaign with a newly licensed meningococcal polysaccharide ACW135 vaccine in Burkina Faso, adverse events following immunization (AEFI) were monitored up to 4 weeks after the campaign. Eighty-six AEFI cases (5.9 cases per 100,000 vaccine doses distributed) were reported. Among 22 serious events, 4 severe local reactions were considered very likely and 4 severe allergic reactions were considered probably related to the vaccination. One fatal case in a child followed protracted seizures of undetermined cause. In a setting with no prior surveillance system, adverse events were reported at rates comparable to documented rates for meningococcal polysaccharide vaccines in other settings. The findings confirm the benefits of the vaccine in the control of meningococcal meningitis.
authors.affiliation: World Health Organization, 20 Avenue Appia, CH-1211 Geneva 27, Switzerland. bentsienchilla@who.int
authors.forename: Adwoa D
authors.initials: AD
authors.lastname: Bentsi-Enchill
authors.forename: Issaka
authors.initials: I
authors.lastname: Zongo
authors.forename: Selma
authors.initials: S
authors.lastname: Khamassi
authors.forename: Robert
authors.initials: R
authors.lastname: Pless
authors.forename: Rigobert
authors.initials: R
authors.lastname: Thombiano
authors.forename: Sylvestre
authors.initials: S
authors.lastname: Tiéndrebéogo
authors.forename: Christopher B
authors.initials: CB
authors.lastname: Nelson
authors.forename: Philippe
authors.initials: P
authors.lastname: Duclos
mesh_terms: D000293:Adolescent; D000328:Adult; D002050:Burkina Faso / Q000453:epidemiology; D016903:Drug Monitoring / Q000379:methods* / Q000706:statistics & numerical data; D064420:Drug-Related Side Effects and Adverse Reactions / Q000453:epidemiology / Q000209:etiology; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D032541:Mass Vaccination / Q000009:adverse effects*; D022401:Meningococcal Vaccines / Q000009:adverse effects* / Q000276:immunology; D038582:Neisseria meningitidis, Serogroup W-135 / Q000276:immunology; D011135:Polysaccharides, Bacterial / Q000276:immunology; D011159:Population Surveillance
chemical_list: D022401:Meningococcal Vaccines; D011135:Polysaccharides, Bacterial