Early music exposure modifies GluR2 protein expression in rat auditory cortex and anterior cingulate cortex.
GluR2, a major subunit in AMPA receptor, plays an important role in brain functional activity. We studied the effect of music exposure during development on the expression level of GluR2 proteins in the auditory cortex (AC) and anterior cingulate cortex (ACC) of SD rats. Rats were divided into three groups, Music1 (exposed to Nostalgy) group, Music2 (exposed to Wishmaster) group, and control (no music exposure) group. For music exposure groups, rats were exposed to music from postnatal day (PND) 14, and the expression levels of GluR2 proteins were determined at PND 28, 42 and 56. For the control group, the expression levels of GluR2 proteins were determined at PND1, 3, 5, 7, 9, 11, 14, 21, 28, 42, and 56. Results showed an age-dependent expression of GluR2 proteins in control rats. In AC, exposure to Music2 dramatically increased the expression of GluR2, while exposure to Music1 had no effect. In ACC, we found remarkable discrepancies in time-dependent expression of GluR2 between music exposed rats and control rats. These results indicate that exposure to music can modify the expression level of GluR2 protein in AC and ACC.
Xu
Feng
F
College of Life Sciences, Institute of Cognitive Neuroscience, East China Normal University, Shanghai 200062, China.
Cai
Rui
R
Xu
Jinghong
J
Zhang
Jiping
J
Sun
Xinde
X
D000161:Acoustic Stimulation; D000375:Aging / Q000502:physiology; D000818:Animals; D000831:Animals, Newborn; D001303:Auditory Cortex / Q000254:growth & development* / Q000378:metabolism; D001307:Auditory Perception / Q000502:physiology*; D018698:Glutamic Acid / Q000378:metabolism; D006179:Gyrus Cinguli / Q000254:growth & development* / Q000378:metabolism; D009146:Music / Q000523:psychology*; D009473:Neuronal Plasticity / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D018091:Receptors, AMPA / Q000378:metabolism*; D009435:Synaptic Transmission / Q000502:physiology; D013995:Time; D015854:Up-Regulation / Q000502:physiology
D018091:Receptors, AMPA; D018698:Glutamic Acid; C104722:glutamate receptor ionotropic, AMPA 2