Isoflavanones from Uraria picta and their antimicrobial activity.
Two isoflavanones, 5,7-dihydroxy-2'-methoxy-3',4'-methylenedioxyisoflavanone (2) and 4',5-dihydroxy-2',3'-dimethoxy-7-(5- hydroxyoxychromen-7yl)-isoflavanone (4) along with six known compounds including isoflavanones, triterpenes and steroids were isolated from the roots of Uraria picta. The structures of these compounds were established unambiguously by UV, IR, MS and a series of 1D and 2D NMR analyses. The minimum inhibitory concentrations (MIC) for these compounds were found to be in the range of 12.5-200 microg/ml against bacteria (both Gram positive and Gram negative) and fungi.
Rahman
M Mukhlesur
MM
Phytochemistry Research Laboratories, Department of Pharmaceutical Sciences, University of Strathclyde, 27 Taylor Street, Glasgow G4 ONR, Scotland, UK.
Gibbons
Simon
S
Gray
Alexander I
AI
D000890:Anti-Infective Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D029624:Ferns / Q000737:chemistry*; D005658:Fungi / Q000187:drug effects; D007529:Isoflavones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification; D013256:Steroids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
C523335:4',5-dihydroxy-2',3'-dimethoxy-7-(5- hydroxyoxychromen-7yl)-isoflavanone; C523334:5,7-dihydroxy-2'-methoxy-3',4'-methylenedioxyisoflavanone; D000890:Anti-Infective Agents; D007529:Isoflavones; D010936:Plant Extracts; D013256:Steroids; D014315:Triterpenes