title: Sensate scaffolds coupled to telemetry can monitor in vivo loading from within a joint over extended periods of time.
abstract: Polymer scaffolds have been used as a tool to provide growth and integration of engineered tissue substrates to repair damaged tissues in many organ systems including articular cartilage. Previous work has shown that "sensate" scaffolds, with integrated strain gauges have the potential for use as both a delivery vehicle for engineered cartilage as well as a device that can measure real time, in vivo joint loading. The purpose of this study was to use an implanted subminiature telemetry system to collect in vivo joint loading measurements over an extended period following placement of a "sensate" scaffold. Measurements were collected from seven of nine sensors that were implanted into the stifles of three canines. The limb loading rates and load distribution through gait were dependent on stride time but did not vary with time post op. The peak loads were not dependent on stride time but significantly increased with time post op. This demonstrated that peak loading measured with "sensate" scaffolds can be used to monitor healing. The portability of the "sensate" scaffolds coupled to telemetry systems highlights the potential use of this system in a clinical research setting to gather important information to improve tissue engineering and rehabilitation regimens.
authors.affiliation: Department of Orthopaedic Surgery, University of Arizona, Tucson, Arizona, USA. cgeffre@email.arizona.edu
authors.forename: Chris P
authors.initials: CP
authors.lastname: Geffre
authors.forename: Cody L
authors.initials: CL
authors.lastname: Bliss
authors.forename: John A
authors.initials: JA
authors.lastname: Szivek
authors.forename: Donald W
authors.initials: DW
authors.lastname: Deyoung
authors.forename: John T
authors.initials: JT
authors.lastname: Ruth
authors.forename: David S
authors.initials: DS
authors.lastname: Margolis
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D001696:Biomechanical Phenomena; D002138:Calibration; D004285:Dogs; D007091:Image Processing, Computer-Assisted; D007596:Joints / Q000502:physiology*; D011091:Polyesters; D013686:Telemetry; D054457:Tissue Scaffolds; D016138:Walking / Q000502:physiology
chemical_list: D001672:Biocompatible Materials; D011091:Polyesters; C041733:poly(1,4-butylene terephthalate)