title: Evidence of an association between mannose binding lectin codon 54 polymorphism and adenoidectomy and/or tonsillectomy in children.
abstract: Mannose binding lectin (MBL) is a calcium-dependent lectin that plays an important role innate immunity by activating the complement pathway. There have been a number of studies describing an association between the MBL genotype and disease susceptibility. MBL deficiency has been described as one of the factors leading to a number of infections in children with recurrent upper respiratory tractus infections (URTI). We hypothesized that MBL deficiency may be associated with recurrent URTI, which requires adenoidectomy and/or adenotonsillectomy. In this study to clarify this hypothesis we investigated whether there may be an association between two low producing MBL variants and adenoidectomy and/or tonsillectomy due to recurrent URTI in children. Blood samples were collected, adenoidectomy and/or tonsillectomy due to recurrent URTI and 50 controls (mean age 80.53 +/- 32.62 months). In all patients and controls codon 54 and codon 57 polymorphisms of the MBL gene were analyzed. None of the subjects from the patient group and control group carried codon 57 polymorphism of the MBL gene. The frequency of low-level MBL genotypes (AB and BB) for codon 54 polymorphism in the patient group was found to be significantly higher compared to the control subjects (55.7% versus 14%) (p<0.001). This study shows that the presence of low-level MBL alleles is associated with adenoidectomy and/or tonsillectomy caused by recurrent URTI in children.
authors.affiliation: Department of Pediatrics, Ege University, Izmir, Turkey. guldane.koturoglu@ege.edu.tr
authors.forename: Guldane
authors.initials: G
authors.lastname: Koturoglu
authors.forename: Huseyin
authors.initials: H
authors.lastname: Onay
authors.forename: Rasit
authors.initials: R
authors.lastname: Midilli
authors.forename: Sacide
authors.initials: S
authors.lastname: Pehlivan
authors.forename: Erdem
authors.initials: E
authors.lastname: Eren
authors.forename: Gulcin
authors.initials: G
authors.lastname: Itirli
authors.forename: Zafer
authors.initials: Z
authors.lastname: Kurugol
authors.forename: Fazil
authors.initials: F
authors.lastname: Apaydin
authors.forename: Cihangir
authors.initials: C
authors.lastname: Ozkinay
authors.forename: Ferda
authors.initials: F
authors.lastname: Ozkinay
mesh_terms: D000233:Adenoidectomy; D000483:Alleles; D002648:Child; D003062:Codon; D053938:DNA Fragmentation; D004198:Disease Susceptibility; D005091:Exons; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D037601:Mannose-Binding Lectin / Q000172:deficiency / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012008:Recurrence; D012141:Respiratory Tract Infections / Q000235:genetics* / Q000378:metabolism / Q000601:surgery; D014068:Tonsillectomy
chemical_list: D003062:Codon; C445619:MBL2 protein, human; D037601:Mannose-Binding Lectin