Ventriculovascular coupling in systolic and diastolic heart failure.
Pressure-volume analysis has provided critical insight into ventricular mechanics, and it has elucidated the underlying mechanisms of heart failure (HF). Renewed interest in ventriculovascular coupling, the interaction of the left ventricle and the arterial system, has developed from recent investigations focusing on the importance of heart rate control in systolic HF, blood pressure lability in the elderly, and acute pulmonary edema in patients with HF and a normal ejection fraction. These data suggest that abnormal ventriculovascular coupling may be an additional pathophysiologic mechanism underlying the development of HF with a normal ejection fraction and may provide a target for novel therapies.
Fox
Justin M
JM
Clinical Cardiovascular Research Laboratory for the Elderly, Allen Pavilion of New York Presbyterian Hospital, 5141 Broadway, 3 Field West, Room 035, New York, NY 10034, USA.
Maurer
Mathew S
MS