title: Host genetic resistance to symptomatic norovirus (GGII.4) infections in Denmark.
abstract: A total of 61 individuals involved in five norovirus outbreaks in Denmark were genotyped at nucleotides 428 and 571 of the FUT2 gene, determining secretor status, i.e., the presence of ABH antigens in secretions and on mucosa. A strong correlation (P = 0.003) was found between the secretor phenotype and symptomatic disease, extending previous knowledge and confirming that nonsense mutations in the FUT2 gene provide protection against symptomatic norovirus (GGII.4) infections.
authors.affiliation: Division of Molecular Virology, Medical Faculty, University of Linköping, Linköping, Sweden.
authors.forename: Elin
authors.initials: E
authors.lastname: Kindberg
authors.forename: Britt
authors.initials: B
authors.lastname: Akerlind
authors.forename: Christina
authors.initials: C
authors.lastname: Johnsen
authors.forename: Jenny Dahl
authors.initials: JD
authors.lastname: Knudsen
authors.forename: Ole
authors.initials: O
authors.lastname: Heltberg
authors.forename: Göran
authors.initials: G
authors.lastname: Larson
authors.forename: Blenda
authors.initials: B
authors.lastname: Böttiger
authors.forename: Lennart
authors.initials: L
authors.lastname: Svensson
mesh_terms: D017250:Caliciviridae Infections / Q000453:epidemiology / Q000235:genetics* / Q000821:virology; D018389:Codon, Nonsense; D003718:Denmark; D004196:Disease Outbreaks; D005647:Fucosyltransferases / Q000235:genetics*; D005838:Genotype; D006801:Humans; D007113:Immunity, Innate / Q000235:genetics*; D000097631:Galactoside 2-alpha-L-fucosyltransferase
chemical_list: D018389:Codon, Nonsense; D005647:Fucosyltransferases; D000097631:Galactoside 2-alpha-L-fucosyltransferase