dl-3n-butylphthalide prevents stroke via improvement of cerebral microvessels in RHRSP.
The purpose of the study is to establish a model of cold-induced stroke in hypertensive rats, and to study the preventive effect of dl-3n-butylphthalide ( NBP ) on stroke. Stroke-prone renovascular hypertension(RHRSP) was created in Sprague-Dawley rats. The animals were assigned randomly to NBP, aspirin treated and vehicle control group, with administration of the medications for 7 days, and then subjected to cold treatment in an environmentally controlled chamber for 3 days to induce the occurrence of stroke. The incidence of stroke, the volume of the brain lesion, patency of the microvessels by FITC-dextran perfusion and the number of microvessels by immunohisochemical detection of vwF were investigated. Cold induced different types of stroke in RHRSP. The incidence of ischemic stroke and the volume of the infarct were decreased, and the perfused microvessels were increased with NBP pretreatment. Our data suggest that NBP prevents cold-induced ischemic stroke via improvement of cerebral microvessels.
Liu
Chun-Ling
CL
The Department of Neurology, the First Affiliated Hospital of Sun Yat-sen University, Guang Zhou 510080, PR China.
Liao
Song-Jie
SJ
Zeng
Jin-Sheng
JS
Lin
Jian-Wen
JW
Li
Chang-Xin
CX
Xie
Long-Chang
LC
Shi
Xiao-Geng
XG
Huang
Ru-Xun
RX
D000818:Animals; D001241:Aspirin / Q000627:therapeutic use; D001572:Benzofurans / Q000737:chemistry / Q000627:therapeutic use*; D001921:Brain / Q000098:blood supply / Q000473:pathology / Q000503:physiopathology; D002545:Brain Ischemia / Q000188:drug therapy / Q000503:physiopathology / Q000517:prevention & control; D002536:Cerebral Arteries / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology; D002560:Cerebrovascular Circulation / Q000187:drug effects / Q000502:physiology; D003080:Cold Temperature / Q000009:adverse effects; D003911:Dextrans; D004195:Disease Models, Animal; D016650:Fluorescein-5-isothiocyanate / Q000031:analogs & derivatives; D006977:Hypertension, Renal / Q000150:complications* / Q000503:physiopathology; D008297:Male; D008833:Microcirculation / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology; D015394:Molecular Structure; D018696:Neuroprotective Agents / Q000737:chemistry / Q000627:therapeutic use; D051381:Rats; D017207:Rats, Sprague-Dawley; D020521:Stroke / Q000503:physiopathology / Q000517:prevention & control*; D016896:Treatment Outcome
D001572:Benzofurans; D003911:Dextrans; D018696:Neuroprotective Agents; C015219:fluorescein isothiocyanate dextran; C027125:3-n-butylphthalide; D016650:Fluorescein-5-isothiocyanate; D001241:Aspirin