title: [Small-cell lung cancer diagnostic and therapeutic recommendations of Polish Lung Cancer Group].
abstract: Small-cell lung cancer is characterized by an aggressive clinical course with high tendency for early dissemination. At presentation, patients are usually symptomatic and with hilar or mediastinal mass at radiography. Staging should be focused on identifying any evidence of distant spread. Chemotherapy including cisplatin and etoposide is a cornerstone of treatment for all patients. Limited-stage disease should be managed by chemotherapy combined with concurrent chest irradiation. All patients who achieve complete response should be considered for elective cranial irradiation. Surgical treatment may be used in highly selected patients with TNM stage I disease, and surgery should always be combined with chemotherapy. Extensive-stage disease should be managed by multi-agent chemotherapy alone. Long-term survivors should undergo careful monitoring for development of a second primary tumour.
authors.affiliation: Centrum Onkologii -- Instytut w Warszawie. maciekk@coi.waw.pl
authors.forename: Maciej
authors.initials: M
authors.lastname: Krzakowski
authors.forename: Tadeusz
authors.initials: T
authors.lastname: Orłowski
authors.forename: Kazimierz
authors.initials: K
authors.lastname: Roszkowski
authors.forename: Marian
authors.initials: M
authors.lastname: Reinfuss
authors.forename: Włodzimierz
authors.initials: W
authors.lastname: Olszewski
authors.forename: Rodryg
authors.initials: R
authors.lastname: Ramlau
authors.forename: Dariusz
authors.initials: D
authors.lastname: Kowalski
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Konopa
authors.forename: Jacek
authors.initials: J
authors.lastname: Jassem
authors.forename: Renata
authors.initials: R
authors.lastname: Jankowska
authors.forename: Jerzy
authors.initials: J
authors.lastname: Kozielski
authors.forename: Marek
authors.initials: M
authors.lastname: Wojtukiewicz
authors.forename: Kazimierz
authors.initials: K
authors.lastname: Drosik
authors.forename: Piotr
authors.initials: P
authors.lastname: Koralewski
mesh_terms: D000970:Antineoplastic Agents; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000532:radiotherapy / Q000556:secondary; D018288:Carcinoma, Small Cell / Q000175:diagnosis* / Q000473:pathology / Q000556:secondary / Q000628:therapy*; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy / Q000592:standards; D005047:Etoposide / Q000008:administration & dosage; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy*; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control; D009367:Neoplasm Staging; D009378:Neoplasms, Multiple Primary / Q000517:prevention & control; D011013:Pneumonectomy; D011379:Prognosis; D012074:Remission Induction
chemical_list: D000970:Antineoplastic Agents; D005047:Etoposide; D002945:Cisplatin