title: Epstein-Barr Virus Associated Nasopharyngeal Carcinoma and Local Polymorphic B-Cell Lymphoproliferative Disorder in a Patient With HIV Disease.
abstract: A rare case report of HIV-associated nasopharyngeal carcinoma concurrent with local polymorphic B-cell lymphoproliferative disorder is reported and discussed on the ground of the most recent literature evidences. Only very few reports of nasopharyngeal carcinoma have been described until now in patients infected with HIV (one case in adults), and a coexisting lymphoid cell proliferation with a concurrent role of Epstein-Barr virus in prompting both disorders was never reported to date. The relevant pathogenetic, diagnostic, and therapeutic questions raised by this infrequent intriguing association retrieved in a patient with prominent HIV-related immunodeficiency are focused on.
authors.affiliation: Department of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Bologna Alma Mater Studiorum, S. Orsola Hospital, Bologna, Italy. Roberto.manfredi@unibo.it
authors.forename: Roberto
authors.initials: R
authors.lastname: Manfredi
authors.forename: Sergio
authors.initials: S
authors.lastname: Sabbatani
authors.forename: Umberto
authors.initials: U
authors.lastname: Gianelli
authors.forename: Ginevra
authors.initials: G
authors.lastname: Marinacci
mesh_terms: D001402:B-Lymphocytes; D020031:Epstein-Barr Virus Infections; D015658:HIV Infections / Q000188:drug therapy; D004854:Herpesvirus 4, Human; D006801:Humans; D008232:Lymphoproliferative Disorders