title: Bioactive polyketides from Peperomia duclouxii.
abstract: Four new compounds (1-4) were isolated along with 16 known compounds from whole plants of Peperomia duclouxii. The new structures were elucidated as 4-hydroxy-2-[(3,4-methylenedioxyphenyl)nonanoyl]cyclohexane-1,3-dione (1), 4-hydroxy-2-[(3,4-methylenedioxyphenyl)undecanoyl]cyclohexane-1,3-dione (2), 4-hydroxy-2-[(3,4-methylenedioxyphenyl)tridecanoyl]cyclohexane-1,3-dione (3), and 2-[(3,4-methylenedioxyphenyl)dodecyl]-4-hydroxy-2,3,4,6,7,8-hexahydro-2H-1-benzopyran-5-one (4), by analysis of their spectroscopic data. The known polyketides, surinone A and oleiferinone, showed cell growth inhibitory activity against the WI-38, VA-13, and HepG2 cell lines with IC50 values that ranged from 4.4 to 9.6 microg/mL. The known sesquiterpenoid, sinugibberodiol, showed a more potent effect on calcein accumulation than verapamil at 2.5 and 25 microg/mL. Compounds 3 and 4, surinone A, and oleiferinone showed moderate to weak inhibitory activity on the induction of the intercellular adhesion molecule-1 (ICAM-1) in the presence of IL-1alpha or TNF-alpha.
authors.affiliation: National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 189 Guo Shou Jing Road, Zhangjiang Hi-Tech Park, Shanghai 201203, People's Republic of China. nali9898@hotmail.com
authors.forename: Na
authors.initials: N
authors.lastname: Li
authors.forename: Jian-lin
authors.initials: JL
authors.lastname: Wu
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Hasegawa
authors.forename: Jun-ichi
authors.initials: J
authors.lastname: Sakai
authors.forename: Li-ming
authors.initials: LM
authors.lastname: Bai
authors.forename: Li-yan
authors.initials: LY
authors.lastname: Wang
authors.forename: Saori
authors.initials: S
authors.lastname: Kakuta
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Furuya
authors.forename: Hirotsugu
authors.initials: H
authors.lastname: Ogura
authors.forename: Takao
authors.initials: T
authors.lastname: Kataoka
authors.forename: Akihiro
authors.initials: A
authors.lastname: Tomida
authors.forename: Takashi
authors.initials: T
authors.lastname: Tsuruo
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Ando
mesh_terms: D003512:Cyclohexanones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005260:Female; D005452:Fluoresceins / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D018799:Intercellular Adhesion Molecule-1 / Q000187:drug effects; D053582:Interleukin-1alpha / Q000378:metabolism; D015394:Molecular Structure; D036941:Peperomia / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D014407:Tumor Cells, Cultured; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D014700:Verapamil / Q000494:pharmacology
chemical_list: D003512:Cyclohexanones; D004365:Drugs, Chinese Herbal; D005452:Fluoresceins; D053582:Interleukin-1alpha; D012717:Sesquiterpenes; D014409:Tumor Necrosis Factor-alpha; C504392:sinugibberodiol; D018799:Intercellular Adhesion Molecule-1; D014700:Verapamil; C007740:fluorexon