NASH and the risk of cirrhosis and hepatocellular carcinoma in type 2 diabetes.
The risk of chronic liver disease and liver-related mortality is increased in patients with type 2 diabetes mellitus. Several cohort studies have suggested a metabolic pathway from nonalcoholic fatty liver, nonalcoholic steatohepatitis, cryptogenic cirrhosis, and eventually hepatocellular carcinoma. Although cardiovascular risk remains the major cause for excess mortality in type 2 diabetes mellitus, the risk of progressive liver disease should no longer be underscored.
Bugianesi
Elisabetta
E
Division of Gastro-Hepatology, University of Turin, S. Giovanni Battista Hospital, Corso Bramante 88, Turin 10126, Italy. ebugianesi@yahoo.it
Vanni
Ester
E
Marchesini
Giulio
G
D006528:Carcinoma, Hepatocellular / Q000453:epidemiology / Q000209:etiology*; D015331:Cohort Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000453:epidemiology; D005234:Fatty Liver / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D006801:Humans; D008103:Liver Cirrhosis / Q000453:epidemiology / Q000209:etiology; D008107:Liver Diseases / Q000453:epidemiology / Q000209:etiology*; D008297:Male; D015995:Prevalence