title: Insulin resistance and acute coronary syndrome in the young Japanese population have a strong association.
abstract: There are few data regarding acute coronary syndrome (ACS) in young Japanese patients. We examined the risk factors for ACS in young Japanese patients, especially impaired glucose metabolism. From a database of 789 consecutive patients admitted to our hospital with ACS between 2000 and 2005, we compared risk factors of patients divided into two age categories: < or =45 years (group Y, n = 41) and > or =46 years (group O, n = 748). All patients in group Y were male. Overt diabetes, hypertension, and a family history of ischemic heart disease were not so important to group Y. Higher triglyceride (160.5 +/- 86.0 vs 133.9 +/- 75.2 mg/dl, P = 0.0296) and lower high-density lipoprotein cholesterol (43.9 +/- 12.1 vs 48.7 +/- 13.5 mg/dl, P = 0.027) concentrations were present in group Y. We obtained data concerning insulin resistance in 326 of 789 patients. Although the incidence of impaired glucose tolerance was similar between the groups (31% vs 31%, not significant), a higher homeostasis model assessment insulin resistance index (2.26 +/- 2.03), indicating insulin resistance, was present in group Y. Insulin resistance might be correlated with the development of ACS in the young adult Japanese population.
authors.affiliation: Division of Cardiovascular Medicine, Toho University Ohashi Medical Center, Tokyo, Japan. ikedanobutaka@yahoo.co.jp
authors.forename: Nobutaka
authors.initials: N
authors.lastname: Ikeda
authors.forename: Rintaro
authors.initials: R
authors.lastname: Nakajima
authors.forename: Taro
authors.initials: T
authors.lastname: Tsunoda
authors.forename: Masato
authors.initials: M
authors.lastname: Nakamura
authors.forename: Kaoru
authors.initials: K
authors.lastname: Sugi
mesh_terms: D000208:Acute Disease; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D016009:Chi-Square Distribution; D003327:Coronary Disease / Q000453:epidemiology* / Q000378:metabolism; D005260:Female; D018149:Glucose Intolerance / Q000453:epidemiology* / Q000378:metabolism; D006801:Humans; D015994:Incidence; D007333:Insulin Resistance; D007564:Japan / Q000453:epidemiology; D008297:Male; D012307:Risk Factors
chemical_list: D001786:Blood Glucose