Very early alloantigen-independent trafficking of lymphocytes during ischemic acute kidney injury.
Lymphocytes play an important role during ischemia-reperfusion injury (IRI). Lai et al. have demonstrated, for the first time, an increase in kidney lymphocytes 1 hour after IRI, a newly identified kidney lymphocyte reservoir, and have confirmed the pathogenic role of lymphocytes by manipulating the sphingosine-1-phosphate (SIP)-sphingosine-1-phosphate type 1 (S1P1) receptor pathway.
Gandolfo
M T
MT
Department of Pathology, Johns Hopkins University, Baltimore, Maryland, USA.
Rabb
H
H
D000818:Animals; D002465:Cell Movement; D007519:Isoantigens / Q000276:immunology*; D007668:Kidney / Q000098:blood supply* / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology*; D008246:Lysophospholipids / Q000502:physiology; D008297:Male; D051379:Mice; D049349:Receptors, Lysosphingolipid / Q000502:physiology; D015427:Reperfusion Injury / Q000276:immunology*; D013110:Sphingosine / Q000031:analogs & derivatives / Q000502:physiology
D007519:Isoantigens; D008246:Lysophospholipids; D049349:Receptors, Lysosphingolipid; C060506:sphingosine 1-phosphate; D013110:Sphingosine