Efficacy of vaginal danazol treatment in women with recurrent deeply infiltrating endometriosis.
OBJECTIVE
To describe a safe long-term medical treatment for deeply infiltrating endometriosis, a critical condition characterized by multiple painful symptoms and a high recurrence rate after surgical treatment.


METHODS
Prospective study.


METHODS
University of Siena.


METHODS
Twenty-one women with deeply infiltrating endometriosis.


METHODS
In a nonrandomized prospective study a low dose of vaginal danazol (200 mg/d) was self-administered for 12 months. After a previous laparoscopic surgery, these patients had reported recurrent severe dyspareunia, dysmenorrhea, and pelvic pain (in five cases also painful defecation).


METHODS
Before and every 3 months during the treatment a visual analogue pain scale was used. Transvaginal and transrectal ultrasound examinations were performed before and after 6 and 12 months of treatment. Adverse effects were registered, and serum concentration of cholesterol, triglycerides, aspartate aminotransferase, alanine aminotransferase, glycemia, protein S, protein C, antithrombin III, and homocysteine was evaluated before and after 12 months.


RESULTS
Dysmenorrhea, dyspareunia, and pelvic pain significantly decreased within 3 months and disappeared after 6 months of treatment, with a persistent effect during the 12 months of treatment. A relief of painful defecation was also shown. Ultrasound examination showed a reduction of the nodularity in the rectovaginal septum within 6 months. The medical treatment did not affect metabolic or thrombophilic parameters; few local vaginal adverse effects were reported.


CONCLUSIONS
Vaginal danazol resulted in effective medical treatment for the various painful symptoms in women with recurrent deeply infiltrating endometriosis, and because of the lack of significant adverse effects it may be proposed as an alternative to repeated surgery.
Razzi
Sandro
S
Division of Obstetrics and Gynecology, Department of Pediatrics, Gynecology and Reproductive Medicine, University of Siena, Siena, Italy.
Luisi
Stefano
S
Calonaci
Francesco
F
Altomare
Aldo
A
Bocchi
Caterina
C
Petraglia
Felice
F
D000282:Administration, Intravaginal; D000328:Adult; D003613:Danazol / Q000008:administration & dosage*; D004715:Endometriosis / Q000188:drug therapy*; D005260:Female; D006801:Humans; D011446:Prospective Studies; D012008:Recurrence
D003613:Danazol