[The response to environmental pH of RIM101 pathway in Candida albicans].
Abstract: Candida albicans is the most common kind of human opportunistic pathogen and gets many attentions in recent years. A lot of research has been done. The sites this organism colonizes differ in pH. C. albicans must be able to response to the environmental changes for its survival and pathogenicity. Extracellular environment, especially pH changes,is critical for C. albicans morphological differentiation and virulence. RIM101 pathway is a conserved fungal signal transduction pathway and at least partly controls the cellular pH response through the activity of the zinc finger transcription factor Rim101p. This review concisely summarized recent research on RIM101 pathway, pH response and their relationship in C. albicans.
Li
Ming-chun
MC
Tianjin Key Laboratory of Microbial Functional Genomics, Department of Microbiology, Nankai University, Tianjin 300071, China. lmchun68@yahoo.com.cn
Liang
Yong
Y
Wei
Dong-sheng
DS
Xing
Lai-jun
LJ
D002176:Candida albicans / Q000502:physiology*; D004268:DNA-Binding Proteins / Q000502:physiology*; D005656:Fungal Proteins / Q000502:physiology*; D006863:Hydrogen-Ion Concentration; D015398:Signal Transduction / Q000502:physiology*
D004268:DNA-Binding Proteins; D005656:Fungal Proteins; C489602:RIM101 protein, Candida albicans