title: Developed pulsatile flow in a deployed coronary stent.
abstract: The patho-physiologic process of restenosis and tissue growth may not be completely eliminated and is the primary concern of clinicians performing angioplasty and stent implantation procedures. Recent evidence suggests that the restenosis process is influenced by several factors: (1) geometry and size of vessel; (2) stent design; and (3) it's location that alter hemodynamic parameters, including local wall shear stress (WSS) distributions. The present three-dimensional (3D) analysis of pulsatile flow in a deployed coronary stent: (1) shows complex 3D variation of hemodynamic parameters; and (2) quantifies the changes in local WSS distributions for developed flow and compares with recently published WSS data for developing flow. Higher order of magnitude of WSS of 290 dyn/cm(2) is observed on the surface of cross-link intersections at the entrance of the stent for developed flow, which is about half of that for developing flow. Low WSS of 0.8 dyn/cm(2) and negative WSS of -8 dyn/cm(2) are seen at the immediate upstream and downstream regions of strut intersections. Persistent recirculation is observed at the downstream region of each strut cross-link and the regions of low and negative WSS may lead to patho-physiologic conditions near the stented region. The key finding of this study is that the location of stent in the coronary artery determines the developing or developed nature of the flow, which in turn, results in varied level of WSS.
authors.affiliation: Mechanical Engineering Department, University of Cincinnati, Cincinnati, OH 45221-0072, USA. rupak.banerjee@uc.edu
authors.forename: Rupak K
authors.initials: RK
authors.lastname: Banerjee
authors.forename: Surendra B
authors.initials: SB
authors.lastname: Devarakonda
authors.forename: Divakar
authors.initials: D
authors.lastname: Rajamohan
authors.forename: Lloyd H
authors.initials: LH
authors.lastname: Back
mesh_terms: D001775:Blood Circulation / Q000502:physiology; D003331:Coronary Vessels / Q000502:physiology*; D054855:Drug-Eluting Stents; D006801:Humans; D008955:Models, Cardiovascular; D011673:Pulsatile Flow / Q000502:physiology*; D012039:Regional Blood Flow / Q000502:physiology; D015607:Stents