title: Imaging pancreatic cancer using surface-functionalized quantum dots.
abstract: In this study, CdSe/CdS/ZnS quantum dots (QDs) were used as optical contrast agent for imaging pancreatic cancer cells in vitro using transferrin and anti-Claudin-4 as targeting ligands. CdSe/CdS/ZnS was chosen because the CdSe/CdS/ZnS QDs have better photoluminescence (PL) efficiency and stability than those of CdSe/ZnS. The transferrin-mediated targeting is demonstrated in both a cell-free coprecipitation assay as well as using in vitro confocal microscopy. Pancreatic cancer specific uptake is also demonstrated using the monoclonal antibody anti-Claudin-4. This targeted QD platform will be further modified for the purpose of developing as an early detection imaging tool for pancreatic cancer.
authors.forename: Jun
authors.initials: J
authors.lastname: Qian
authors.forename: Ken-Tye
authors.initials: KT
authors.lastname: Yong
authors.forename: Indrajit
authors.initials: I
authors.lastname: Roy
authors.forename: Tymish Y
authors.initials: TY
authors.lastname: Ohulchanskyy
authors.forename: Earl J
authors.initials: EJ
authors.lastname: Bergey
authors.forename: Hoon Hi
authors.initials: HH
authors.lastname: Lee
authors.forename: Kenneth M
authors.initials: KM
authors.lastname: Tramposch
authors.forename: Sailing
authors.initials: S
authors.lastname: He
authors.forename: Anirban
authors.initials: A
authors.lastname: Maitra
authors.forename: Paras N
authors.initials: PN
authors.lastname: Prasad
mesh_terms: D045744:Cell Line, Tumor; D003287:Contrast Media; D006801:Humans; D046529:Microscopy, Electron, Transmission; D010190:Pancreatic Neoplasms / Q000175:diagnosis* / Q000473:pathology*; D045663:Quantum Dots
chemical_list: D003287:Contrast Media