Estrogen-TGFbeta cross-talk in bone and other cell types: role of TIEG, Runx2, and other transcription factors.
It is well established that E(2) and TGFbeta have major biological effects in multiple tissues, including bone. The signaling pathways through which these two factors elicit their effects are well documented. However, the interaction between these two pathways and the potential consequences of cross-talk between E(2) and TGFbeta continue to be elucidated. In this prospectus, we present known and potential roles of TIEG, Runx2, and other transcription factors as important mediators of signaling between these two pathways.
Hawse
J R
JR
Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.
Subramaniam
M
M
Ingle
J N
JN
Oursler
M J
MJ
Rajamannan
N M
NM
Spelsberg
T C
TC
D000818:Animals; D016723:Bone Remodeling / Q000502:physiology; D001842:Bone and Bones / Q000378:metabolism*; D050659:Core Binding Factor Alpha 1 Subunit / Q000502:physiology*; D004268:DNA-Binding Proteins / Q000502:physiology*; D019281:Dimerization; D051765:Early Growth Response Transcription Factors / Q000502:physiology*; D004967:Estrogens / Q000502:physiology*; D005260:Female; D051741:Kruppel-Like Transcription Factors / Q000502:physiology*; D020935:MAP Kinase Signaling System / Q000502:physiology; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D010006:Osteoblasts / Q000378:metabolism; D010010:Osteoclasts / Q000378:metabolism; D020033:Protein Isoforms / Q000235:genetics / Q000502:physiology; D051381:Rats; D015398:Signal Transduction / Q000502:physiology*; D014157:Transcription Factors / Q000502:physiology*; D014158:Transcription, Genetic; D016212:Transforming Growth Factor beta / Q000172:deficiency / Q000235:genetics / Q000502:physiology*
D050659:Core Binding Factor Alpha 1 Subunit; D004268:DNA-Binding Proteins; D051765:Early Growth Response Transcription Factors; D004967:Estrogens; D051741:Kruppel-Like Transcription Factors; D020033:Protein Isoforms; D014157:Transcription Factors; D016212:Transforming Growth Factor beta; C098111:KLF10 protein, human; C569958:KLF10 protein, mouse