Colorectal neoplasm in asymptomatic Asians: a prospective multinational multicenter colonoscopy survey.
BACKGROUND
Colorectal neoplasm is rapidly increasing in Asia, but a guideline for screening is not available.


OBJECTIVE
To evaluate the characteristics of colorectal neoplasm in asymptomatic Asian subjects.


METHODS
Prospective cohort study.


METHODS
Multinational multicenters, including both primary and referral centers in Asia.


METHODS
A total of 860 consecutive asymptomatic adults undergoing screening colonoscopy in 11 Asian cities from July 2004 to December 2004. Patients under 16 years old; those patients with a colorectal resection history, colonoscopies, or barium enema within 5 years; symptoms suggestive of colorectal diseases; and those who had undergone surveillance colonoscopy were excluded.


METHODS
The incidence and distribution of colorectal neoplasm and advanced neoplasm.


RESULTS
The mean age (+/-SD) was 54.4+/-11.6 years; 471 were men (54.8%). The prevalence of colorectal neoplasm and advanced neoplasm was 18.5% and 4.5%, respectively. Male sex, advancing age, and a family history of colorectal cancer were risk factors for advanced neoplasm. Of the 168 patients with colorectal neoplasm, 76 had distal neoplasm only (45.2%), 66 had proximal neoplasm only (39.3%), and 26 had both proximal and distal neoplasms (15.5%). Although the presence of distal advanced neoplasm was a significant risk factor for proximal advanced neoplasm, 14 of the 758 subjects without distal neoplasm had proximal advanced neoplasm (1.8%).


CONCLUSIONS
The small number of enrolled subjects, especially from certain ethnic groups.


CONCLUSIONS
The overall prevalence of advanced colorectal neoplasm in asymptomatic Asians is comparable with the West. Male sex, advancing age, and a family history of colorectal cancer were associated with a higher risk of advanced neoplasm.
Byeon
Jeong-Sik
JS
Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
Yang
Suk-Kyun
SK
Kim
Tae Il
TI
Kim
Won Ho
WH
Lau
James Y W
JY
Leung
Wai-Keung
WK
Fujita
Rikiya
R
Makharia
Govind K
GK
Abdullah
Murdan
M
Hilmi
Ida
I
Sollano
Jose
J
Yeoh
Khay-Guan
KG
Wu
Deng-Chyang
DC
Chen
Min Hu
MH
Kongkam
Pradermchai
P
Sung
Joseph J Y
JJ
D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D003113:Colonoscopy; D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000208:ethnology*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011159:Population Surveillance / Q000379:methods*; D015995:Prevalence; D011446:Prospective Studies; D012307:Risk Factors; D017678:Sex Distribution