title: A metabonomic study of strain- and age-related differences in the Zucker rat.
abstract: Ultra-performance liquid chromatography (UPLC) coupled to orthogonal acceleration time-of-flight mass spectrometry (oa-TOFMS) in positive electrospray ionization mode was used to obtain metabolite profiles for urine obtained from three strains of Zucker rat. These were the Zucker lean, the Zucker (fa/fa) obese and the Zucker lean/(fa) cross. Clear age- and strain-related differences were noted with the leptin-deficient (fa/fa) obese animal showing significant differences from both the other Zucker rat strains with respect to metabolite profiles.
authors.affiliation: AstraZeneca R&D Boston, 35 Gatehouse Drive, Waltham, MA 02451, USA. jennifer.granger@asu.edu
authors.forename: Jennifer H
authors.initials: JH
authors.lastname: Granger
authors.forename: Rebecca
authors.initials: R
authors.lastname: Williams
authors.forename: Eva M
authors.initials: EM
authors.lastname: Lenz
authors.forename: Robert S
authors.initials: RS
authors.lastname: Plumb
authors.forename: Chris L
authors.initials: CL
authors.lastname: Stumpf
authors.forename: Ian D
authors.initials: ID
authors.lastname: Wilson
mesh_terms: D000367:Age Factors; D000818:Animals; D002853:Chromatography, Liquid; D003433:Crosses, Genetic; D013058:Mass Spectrometry; D009765:Obesity / Q000235:genetics*; D051381:Rats; D011924:Rats, Zucker / Q000235:genetics* / Q000378:metabolism* / Q000652:urine; D021241:Spectrometry, Mass, Electrospray Ionization; D013851:Thinness / Q000235:genetics*; D013997:Time Factors