title: Relative cerebral blood volume is a measure of angiogenesis in brain tuberculoma.
abstract: OBJECTIVE
  The aim of this study was to correlate the perfusion indices with magnetic resonance imaging-derived cellular and necrotic fraction of the tuberculoma and angiogenesis metrics on histopathology.
  
  
  METHODS
  We performed dynamic contrast-enhanced magnetic resonance imaging in 13 excised brain tuberculoma patients. Microvascular density and vascular endothelial growth factor (VEGF)-expressing cells were quantified from the excised tuberculoma. The cellular and necrotic fractions of the tuberculomas were quantified on a postcontrast T1-weighted imaging.
  
  
  RESULTS
  Relative cerebral blood volume of cellular portion significantly correlated with cellular fraction volume (r = 0.882, P < 0.001), microvascular density (r = 0.900, P < 0.001), and VEGF (r = 0.886, P < 0.001) of the 13 excised tuberculomas. Microvascular density also correlated significantly with VEGF (r = 0.919, P < 0.001).
  
  
  CONCLUSIONS
  Relative cerebral blood volume is a measure of angiogenesis in the cellular fraction of the brain tuberculoma. This information may be of value in predicting the therapeutic response in future.
authors.affiliation: Department of Radiodiagnosis, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India. rgupta@sgpgi.ac.in
authors.forename: Rakesh K
authors.initials: RK
authors.lastname: Gupta
authors.forename: Mohammad
authors.initials: M
authors.lastname: Haris
authors.forename: Nuzhat
authors.initials: N
authors.lastname: Husain
authors.forename: Mazhar
authors.initials: M
authors.lastname: Husain
authors.forename: Kashi N
authors.initials: KN
authors.lastname: Prasad
authors.forename: Mohan
authors.initials: M
authors.lastname: Pauliah
authors.forename: Chhitiz
authors.initials: C
authors.lastname: Srivastava
authors.forename: Mukesh
authors.initials: M
authors.lastname: Tripathi
authors.forename: Manu
authors.initials: M
authors.lastname: Rastogi
authors.forename: Sanjay
authors.initials: S
authors.lastname: Behari
authors.forename: Anup
authors.initials: A
authors.lastname: Singh
authors.forename: Divya
authors.initials: D
authors.lastname: Rathore
authors.forename: Ram Kishore S
authors.initials: RK
authors.lastname: Rathore
mesh_terms: D000293:Adolescent; D000328:Adult; D001810:Blood Volume; D002648:Child; D002675:Child, Preschool; D003287:Contrast Media; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008833:Microcirculation; D009336:Necrosis; D009389:Neovascularization, Pathologic / Q000473:pathology*; D016862:Tuberculoma, Intracranial / Q000473:pathology*; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
chemical_list: D003287:Contrast Media; D042461:Vascular Endothelial Growth Factor A; C064925:gadodiamide; D019786:Gadolinium DTPA