title: [Effects of 2-n-nonyl-1,3-dioxolane as an enhanceron transdermal absorption of Salvia miltiorrhiza gel].
abstract: OBJECTIVE
  To choose the most suitable concentration of 2-n-nonyl-1,3-dioxolane as a penetration enhancer in tanshinone gel preparation.
  
  
  METHODS
  In vitro, transdermal absorption was studied using improved Frans equipment and rats skin. Tanshinone II A was tested by HPLC.
  
  
  RESULTS
  The 4.0% concentration of 2-n-nonyl-1,3-dioxolane enhanced the transdermal absorption significantly in the preparation.
  
  
  CONCLUSIONS
  2-n-nonyl-1,3-dioxolane was a new effective permeaton enhancer.
authors.affiliation: Fujian College of Traditional Chinese Medicine, Fuzhou 350108, China. orgchemsha@sina.com
authors.forename: Mei
authors.initials: M
authors.lastname: Sha
authors.forename: Li-Fang
authors.initials: LF
authors.lastname: Yin
authors.forename: Wei
authors.initials: W
authors.lastname: Xu
authors.forename: Yu-Zhi
authors.initials: YZ
authors.lastname: Chen
mesh_terms: D045784:Abietanes; D000279:Administration, Cutaneous; D000818:Animals; D004148:Dioxolanes / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000302:isolation & purification / Q000493:pharmacokinetics*; D005260:Female; D005782:Gels; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D010616:Phenanthrenes / Q000032:analysis; D015203:Reproducibility of Results; D027561:Salvia miltiorrhiza / Q000737:chemistry*; D012867:Skin / Q000187:drug effects / Q000378:metabolism; D012869:Skin Absorption / Q000187:drug effects*
chemical_list: D045784:Abietanes; D004148:Dioxolanes; D004365:Drugs, Chinese Herbal; D005782:Gels; D010616:Phenanthrenes; C021751:tanshinone; C111109:2-n-nonyl-1,3-dioxolane