[Effects of Salvia miltiorrhiza on Chlamydia trachomatis mice of salpingitis].
OBJECTIVE
To study the effects of Salvia miltiorrhiza on treatment of Chlamydia trachomatis salpingitis (CTS) and fibrosis.


METHODS
A mouse model for CTS was estahlished in C3H/He by intravaginal inoculation. after 3 weeks mice were randomly divided into 3 groups. Only Azithromyxin was given orally, Azithromyxin and early S. miltiorrhiza given, or Azithromyxin and later S. miltiorrhiza given. After 10 weeks, observe the change of oviduct of mice, observe the histopathologic change and analysis collagen histochemical index.


RESULTS
3 Treatment groups induce tubal occlusion and hydrosalpinx decreased and the collagen histochemical index decreased significantly than those of no treatment given (P < 0.05). Early S. miltiorrhiza given group induce tubal occlusion and hydrosalpinx decreased and the collagen histochemical index decreased significantly than only Azithromyxin group or later S. miltiorrhiza given group (P <0.05).


CONCLUSIONS
When we treat CTS genital infection with Azithromyxin, if we can give S. miltiorrhiza treatment as early as possible, it may decrease tubal occlusion and hydrosalpinx. significantly inhibit fibrosis maybe one of its pharmacologic mechanismin.
Chen
Mu-Kai
MK
The First Affiliated Hospital of Sun Yat-sen university, Guangzhou 510080, China.
Chen
Ze-Xiong
ZX
Han
Jian-De
JD
Liao
Qi-Man
QM
D000818:Animals; D002690:Chlamydia Infections / Q000150:complications / Q000188:drug therapy* / Q000382:microbiology; D002692:Chlamydia trachomatis / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000627:therapeutic use*; D005184:Fallopian Tube Diseases / Q000209:etiology / Q000517:prevention & control; D005187:Fallopian Tubes / Q000187:drug effects / Q000473:pathology; D005260:Female; D005355:Fibrosis; D051379:Mice; D008809:Mice, Inbred C3H; D008517:Phytotherapy; D010946:Plants, Medicinal / Q000737:chemistry; D011897:Random Allocation; D012488:Salpingitis / Q000150:complications / Q000188:drug therapy*; D027561:Salvia miltiorrhiza / Q000737:chemistry*
D004365:Drugs, Chinese Herbal