[Identification of a novel candidate gene KLRC1 within the putative susceptibility locus for systemic lupus erythematosus at 12p12.3-13.2 in a Chinese cohort].
OBJECTIVE
To identify the candidate genes within the putative susceptibility locus for systemic lupus erythematosus (SLE) at 12p12.3-13.2.


METHODS
KLRC1 was selected as the candidate gene according to the results of previous gene chip studies. TaqMan real-time quantitative PCR was performed for detecting KLRC1 mRNA expression in 55 SLE patients and 30 controls.


CONCLUSIONS
KLRC1 mRNA expression was significantly higher in the mononuclear cells and T cells of SLE patients than in the healthy controls (P<0.01), but showed no significant difference in the B cells. No obvious correlation was found between the SLE disease activity index (SLEDAI) and KLRC1expression level, suggesting that KLRC1 can be a probable candidate gene for SLE on 12p12.3-13.2, but which is not associated with the disease activity.
Ren
Li-li
LL
Clinical Medical Research Center, Shenzhen People's Hospital, Shenzhen 518020, China. llren75@hotmail.com
Li
Fu-rong
FR
Liu
Dong-zhou
DZ
Qi
Hui
H
Ouyang
Zhi-bin
ZB
D000293:Adolescent; D000328:Adult; D044466:Asian People / Q000235:genetics; D002681:China; D002881:Chromosomes, Human, Pair 12 / Q000235:genetics*; D005260:Female; D020869:Gene Expression Profiling; D020022:Genetic Predisposition to Disease; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000208:ethnology / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D055654:NK Cell Lectin-Like Receptor Subfamily C / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012720:Severity of Illness Index; D055815:Young Adult
C527054:KLRC1 protein, human; D055654:NK Cell Lectin-Like Receptor Subfamily C