title: Biological effects of noble gases.
abstract: Noble gases are known for their inertness. They do not react chemically with any element at normal temperature and pressure. Through that, some of them are known to be biologically active by their sedative, hypnotic and analgesic properties. Common inhalation anesthetics are characterized by some disadvantages (toxicity, decreased cardiac output, etc). Inhalation of xenon introduces anesthesia and has none of the above disadvantages, hence xenon seems to be the anesthetic gas of the future (with just one disadvantage - its cost). It is known that argon has similar anesthetic properties (under hyperbaric conditions), which is much cheaper and easily accessible. The question is if this could be used in clinical practice, in anesthesia of patients who undergo treatment in the hyperbaric chamber. Xenon was found to be organ-protective. Recent animal experiments indicated that xenon decreases infarction size after ischemic attack on brain or heart. The goal of our study is to check if hyperbaric argon has properties similar to those of xenon.
authors.affiliation: Department of Biophysics, Faculty of Medicine, Charles University, Plzen, Czech Republic. benes@dante.lfp.cuni.cz
authors.forename: J
authors.initials: J
authors.lastname: Růžička
authors.forename: J
authors.initials: J
authors.lastname: Benes
authors.forename: L
authors.initials: L
authors.lastname: Bolek
authors.forename: V
authors.initials: V
authors.lastname: Markvartová
mesh_terms: D018685:Anesthetics, Inhalation / Q000494:pharmacology*; D000818:Animals; D001128:Argon / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D009048:Motor Skills / Q000187:drug effects*; D005741:Noble Gases / Q000494:pharmacology*; D011312:Pressure; D051381:Rats; D012890:Sleep / Q000187:drug effects*; D013997:Time Factors; D014851:Wakefulness / Q000187:drug effects*
chemical_list: D018685:Anesthetics, Inhalation; D005741:Noble Gases; D001128:Argon