Liver regeneration.
Liver regeneration after partial hepatectomy is a very complex and well-orchestrated phenomenon. It is carried out by the participation of all mature liver cell types. The process is associated with signaling cascades involving growth factors, cytokines, matrix remodeling, and several feedbacks of stimulation and inhibition of growth related signals. Liver manages to restore any lost mass and adjust its size to that of the organism, while at the same time providing full support for body homeostasis during the entire regenerative process. In situations when hepatocytes or biliary cells are blocked from regeneration, these cell types can function as facultative stem cells for each other.
Michalopoulos
George K
GK
Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA. michalopoulosgk@upmc.edu
D000818:Animals; D004847:Epithelial Cells / Q000378:metabolism; D006439:Hemodynamics; D006498:Hepatectomy; D022781:Hepatocytes / Q000378:metabolism; D006801:Humans; D015850:Interleukin-6 / Q000378:metabolism; D008099:Liver / Q000166:cytology / Q000196:embryology / Q000502:physiology*; D008115:Liver Regeneration / Q000502:physiology*; D008938:Mitosis / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D013234:Stem Cells / Q000502:physiology; D053773:Transforming Growth Factor beta1 / Q000378:metabolism
D015850:Interleukin-6; D053773:Transforming Growth Factor beta1