Glucose-6-phosphate dehydrogenase polymorphism and lymphoma risk.
OBJECTIVE
Evidence linking the glucose-6-phosphate dehydrogenase (G6PD) polymorphism and risk of non-Hodgkin's lymphoma is conflicting. Risk of non-Hodgkin's lymphoma was increased in subjects expressing the G6PD deficient phenotype, whereas subjects under medication with statins, a lipid-lowering class of drugs partially mimicking G6PD deficiency, seemed to enjoy a protective effect.


METHODS
We conducted a case-control study on lymphoma risk associated with the self-reported G6PD deficient phenotype in 122 lymphoma male cases and 116 male controls in Sardinia, Italy. The association with the GdMed+ genotype, the most frequent variant expressing a deficient enzyme activity, was also tested in 49 male lymphoma cases and 31 controls. The WHO classification was used to identify lymphoma subentities.


RESULTS
Neither self-reported G6PD deficient phenotype nor the GdMed+ genotype showed an association with lymphoma risk or its subentities.


CONCLUSIONS
Our results do not confirm an association either positive or negative between the G6PD polymorphism and lymphoma risk.
Cocco
Pierluigi
P
Department of Public Health, Occupational Health Section, University of Cagliari, Cagliari, Italy. coccop@pacs.unica.it
Ennas
Maria G
MG
Melis
Maria A
MA
Sollaino
Carla
C
Collu
Stefania
S
Fadda
Domenica
D
Gabbas
Attilio
A
Massarelli
Giovannino
G
Rais
Marco
M
Todde
Pierfelice
P
Angelucci
Emanuele
E
D000368:Aged; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D005954:Glucosephosphate Dehydrogenase / Q000235:genetics*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology; D008228:Lymphoma, Non-Hodgkin / Q000209:etiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic
D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D005954:Glucosephosphate Dehydrogenase