[Genetic analysis for prevention of steroid-induced osteonecrosis of the femoral head].
Idiopathic osteonecrosis of the femoral head (ION) is caused by disruption of blood flow. This disease often occurs in association with steroid treatment. The pathology of corticosteroid-induced ION is unclear, although abnormalities in the coagulation and fibrinolytic systems or in the lipid metabolism have been reported to be involved. We found the differences of gene polymorphism frequencies of ATP-binding casette, sub-family B, member 1 (ABCB1) C3435T, Apolipoprotein B (ApoB) C7623T and cAMP-response element binding protein-binding protein (CBP) (rs3751845) between ION cases and referent patients among those who were subjected to renal transplantation. For the prediction of ION, it is useful to analyze ABCB1 C3435T, ApoB C7623T and CBP (rs3751845) before the administration of steroids.
Fujioka
Mikihiro
M
Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Department of Orthopaedics.
Arai
Yuji
Y
Kuribayashi
Masaaki
M
Kubo
Toshikazu
T
Nakajima
Shigeo
S
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000235:genetics; D001055:Apolipoproteins B / Q000235:genetics; D017362:Cyclic AMP Response Element-Binding Protein / Q000235:genetics; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics; D005271:Femur Head Necrosis / Q000139:chemically induced* / Q000235:genetics* / Q000517:prevention & control; D005787:Gene Frequency; D005938:Glucocorticoids / Q000009:adverse effects*; D006801:Humans; D011110:Polymorphism, Genetic
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D001055:Apolipoproteins B; D017362:Cyclic AMP Response Element-Binding Protein; D005938:Glucocorticoids; D003577:Cytochrome P-450 Enzyme System