Preparation and in vivo investigation of artificial cornea made of nano-hydroxyapatite/poly (vinyl alcohol) hydrogel composite.
An artificial cornea consisted of a porous nano-hydroxyapatite/poly (vinyl alcohol) hydrogel (n-HA/PVA-H) skirt and a transparent center poly (vinyl alcohol) hydrogel (PVA-H) were prepared. The n-HA/PVA-H skirt was homogeneously porous and these pores were interconnected. Inter-penetrating network was observed along the interface between the core and the skirt. Artificial corneas were implanted in eyes of rabbit. The corneal tissues were evaluated histological. The results displayed that a good biocompatibility and interlocking had happened between artificial cornea and host tissues. This novel cornea prepared here is potential to be used clinically.
Fenglan
Xu
X
Research Center for Nano-Biomaterials, Analytical and Testing Center, Sichuan University, 610064, Chengdu, PR China.
Yubao
Li
L
Xiaoming
Yao
Y
Hongbing
Liao
L
Li
Zhang
Z
D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D003315:Cornea / Q000098:blood supply / Q000737:chemistry* / Q000166:cytology / Q000648:ultrastructure; D017886:Durapatite / Q000737:chemistry*; D005500:Follow-Up Studies; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000737:chemistry*; D066298:In Vitro Techniques; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D008954:Models, Biological; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure; D011142:Polyvinyl Alcohol / Q000737:chemistry*; D016062:Porosity; D019736:Prostheses and Implants; D011817:Rabbits; D013997:Time Factors
D001672:Biocompatible Materials; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D011142:Polyvinyl Alcohol; D017886:Durapatite