Intravascular ultrasound assessment of remodelling and reference segment plaque burden in type-2 diabetic patients.
OBJECTIVE
Intravascular ultrasound (IVUS) assesses arterial remodelling by comparing the lesion external elastic membrane (EEM) with the reference segments; however, reference segments are rarely disease-free. The aim was to assess lesion and reference segment remodelling and plaque burden in patients with type-2 diabetes mellitus.


RESULTS
We used pre-intervention IVUS to study 62 de novo lesions in 43 patients with type-2 diabetes mellitus. The lesion site was the image slice with the smallest lumen cross-sectional area (CSA). The proximal and distal reference segments were the most normal-looking segments within 5 mm proximal and distal to the lesion. Plaque burden was measured as plaque CSA/EEM CSA. The remodelling index was defined as lesion EEM CSA/mean reference EEM CSA. Reference segment plaque burden measured 0.54 +/- 0.09. The majority of lesions (83.9%) had negative remodelling (lesion EEM < reference). Similarly, the slope of the regression line relating EEM to plaque CSA within the lesion was less than the reference substantiating negative remodelling. The reference segment plaque burden correlated inversely with the difference between IVUS lumen and quantitative coronary angiographic artery size [slope = -0.12 (95% CI -0.17 to -0.07); P < 0.001] in all patients with type-2 diabetes mellitus.


CONCLUSIONS
Lesions in type-2 diabetic patients are different from previous reports in non-diabetics. Lesions in type-2 diabetics are characterized by a large reference segment plaque burden and negative lesion site remodelling. These IVUS findings may explain the angiographic appearance of small arteries in diabetic patients.
Jensen
Lisette Okkels
LO
Catheterization Laboratory, Department of Cardiology, Odense University Hospital, Odense C, Denmark. okkels@dadlnet.dk
Thayssen
Per
P
Mintz
Gary S
GS
Maeng
Michael
M
Junker
Anders
A
Galloe
Anders
A
Christiansen
Evald Hoej
EH
Hoffmann
Soeren K S
SK
Pedersen
Knud Erik
KE
Hansen
Henrik Steen
HS
Hansen
Knud Noerregaard
KN
D000368:Aged; D003331:Coronary Vessels / Q000000981:diagnostic imaging* / Q000473:pathology; D003924:Diabetes Mellitus, Type 2 / Q000000981:diagnostic imaging* / Q000473:pathology; D003925:Diabetic Angiopathies / Q000000981:diagnostic imaging* / Q000473:pathology; D019160:Endosonography; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis; D018084:Ultrasonography, Interventional / Q000379:methods