[Current status of research on conjugates and related drug delivery systems in the treatment of cancer and other diseases].
Drug delivery systems is an umbrella term describing different types of carrier-drug and carrier-protein conjugates, liposomes, polyplexes, micelles, and hybrid types. Such systems were designed with the aim to enhance delivery and to improve the selectivity and pharmacological properties of both conventional drugs and newly developed agents. In this review the current state-of-the-art in the design of drug delivery systems is described, with particular emphasis on agents developed to deliver antitumor agents. The advantages, limitations, and disadvantages of the particular types of drug delivery systems as well as the theoretical and practical basis of their action are also highlighted here. In addition, results of preclinical and clinical studies on the most developed examples of drug delivery systems to date are summarized.
Nevozhay
Dmitry
D
Zakład Onkologii Doświadczalnej, Instytut Immunologii i Terapii Doświadczalnej im. L. Hirszfelda, Polska Akademia Nauk we Wrocławiu, Wrocław, Poland.
Kańska
Urszula
U
Budzyńska
Renata
R
Boratyński
Janusz
J
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D035843:Biomedical Research / Q000639:trends; D002352:Carrier Proteins; D016503:Drug Delivery Systems; D006801:Humans; D000922:Immunotoxins / Q000627:therapeutic use*; D008081:Liposomes / Q000627:therapeutic use; D008823:Micelles; D045423:Microbubbles; D008863:Microspheres; D009369:Neoplasms / Q000188:drug therapy*; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry
D000970:Antineoplastic Agents; D002352:Carrier Proteins; D000922:Immunotoxins; D008081:Liposomes; D008823:Micelles; D011108:Polymers