title: Post-pubertal emergence of alterations in locomotor activity in stop null mice.
abstract: Overt schizophrenia is preceded by a prodromal phase during which juvenile patients display attenuated schizophrenia-related symptoms. Here, we have looked for evidence of a prodromal phase in juvenile STOP null mice, which, during adulthood, imitate features of schizophrenia. We have principally examined locomotor activity, which is abnormal in adult STOP null mice, and its apparent relationship with perturbed glutamatergic and dopaminergic transmission. When compared to corresponding wild-type mice, juvenile STOP null mice did not exhibit the basal hyperlocomotion or locomotor hypersensitivity to mild stress observed in adult mice. Juvenile STOP null mice also lacked disturbed locomotor sensitivity to MK-801, which was evident in adult mice. In contrast, juvenile STOP null mice exhibited a similar hypersensitivity to amphetamine as that found in adult mice. Thus, STOP null mice exhibited both a progression of locomotor activity defects over time and subtle alterations in the prepubertal period. We suggest that the pattern of locomotor disturbances observed in this study is related to altered dopaminergic reactivity in juvenile mice without major disturbance in glutamatergic transmission, whereas both neurotransmitter systems are impaired in adult mice.
authors.affiliation: Institut Fédératif des Neurosciences de Lyon, Bron, France. melina.begou@u-clermont1.fr
authors.forename: Mélina
authors.initials: M
authors.lastname: Bégou
authors.forename: Philippe
authors.initials: P
authors.lastname: Brun
authors.forename: Jean-Baptiste
authors.initials: JB
authors.lastname: Bertrand
authors.forename: Didier
authors.initials: D
authors.lastname: Job
authors.forename: Annie
authors.initials: A
authors.lastname: Schweitzer
authors.forename: Thierry
authors.initials: T
authors.lastname: D'Amato
authors.forename: Mohamed
authors.initials: M
authors.lastname: Saoud
authors.forename: Annie
authors.initials: A
authors.lastname: Andrieux
authors.forename: Marie-Françoise
authors.initials: MF
authors.lastname: Suaud-Chagny
mesh_terms: D000375:Aging / Q000502:physiology*; D000661:Amphetamine / Q000494:pharmacology; D000704:Analysis of Variance; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology*; D000697:Central Nervous System Stimulants / Q000494:pharmacology; D016291:Dizocilpine Maleate / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D005106:Exploratory Behavior / Q000187:drug effects / Q000502:physiology; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D008869:Microtubule-Associated Proteins / Q000172:deficiency*; D009043:Motor Activity / Q000187:drug effects / Q000235:genetics*
chemical_list: D000697:Central Nervous System Stimulants; D018691:Excitatory Amino Acid Antagonists; D008869:Microtubule-Associated Proteins; C491893:Mtap6 protein, mouse; D016291:Dizocilpine Maleate; D000661:Amphetamine