title: Endocrine symptom assessment in women with breast cancer: what a simple "yes" means.
abstract: OBJECTIVE
  To investigate the self-reported symptoms related to endocrine therapy in women with early or advanced breast cancer and the impact of these symptoms on quality of life (QL) indicators.
  
  
  METHODS
  Symptom occurrence was assessed by the Checklist for Patients on Endocrine Therapy (C-PET) and symptom intensity was assessed by linear analogue self-assessment (LASA) indicators. Patients also responded to global LASA indicators for physical well-being, mood, coping effort and treatment burden. Associations between symptoms and these indicators were analysed by linear regression models.
  
  
  RESULTS
  Among 373 women, the distribution of symptom intensity showed considerable variation in patients reporting a symptom as present. Even though patients recorded a symptom as absent, some patients reported having experienced that symptom when responding to symptom intensity, as seen for decreased sex drive, tiredness and vaginal dryness. Six of 13 symptoms and lower age had a detrimental impact on the global indicators, particularly tiredness and irritability.
  
  
  CONCLUSIONS
  Patients' experience of endocrine symptoms needs to be considered both in patient care and research, when interpreting the association between symptoms and QL.
authors.affiliation: International Breast Cancer Study Group, Coordinating Center, Effingerstrasse 40, 3008, Bern, Switzerland. karin.ribi@ibcsg.org
authors.forename: K
authors.initials: K
authors.lastname: Ribi
authors.forename: J
authors.initials: J
authors.lastname: Bernhard
authors.forename: K
authors.initials: K
authors.lastname: Rufibach
authors.forename: B
authors.initials: B
authors.lastname: Thürlimann
authors.forename: R
authors.initials: R
authors.lastname: von Moos
authors.forename: T
authors.initials: T
authors.lastname: Ruhstaller
authors.forename: A
authors.initials: A
authors.lastname: Glaus
authors.forename: C
authors.initials: C
authors.lastname: Böhme
mesh_terms: D000223:Adaptation, Psychological; D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000523:psychology; D004703:Endocrine System / Q000503:physiopathology*; D004700:Endocrine System Diseases / Q000175:diagnosis* / Q000209:etiology; D005260:Female; D006305:Health Status Indicators; D006306:Health Surveys; D006801:Humans; D008875:Middle Aged; D011581:Psychological Tests; D011594:Psychometrics; D011788:Quality of Life; D012720:Severity of Illness Index; D018434:Sickness Impact Profile; D011795:Surveys and Questionnaires