Platelet aggregation abnormalities in patients with recurrent fetal losses.
BACKGROUND
There are some studies reporting that platelets might have a role in cases with recurrent fetal losses. The aim of this study is to evaluate the importance of platelet aggregation abnormalities in this patient group.


METHODS
In this study, platelet aggregation abnormalities were compared in 56 cases with recurrent fetal losses (29 of these 56 patients have >or=3 losses) and in 33 healthy female controls with no previous history of fetal loss. Platelet aggregation studies were performed with optical turbidometric method by using ADP (5 microM), collagen (0.2 mg/ml) and epinephrine (10 microM).


RESULTS
We did not find any statistically significant difference between patient (56 cases with >or=2 fetal losses and 29 of them with >or=3 fetal losses) and control groups for platelet aggregation abnormalities.


CONCLUSIONS
The data we have obtained suggest that severe platelet aggregation abnormalities are not the rule in patients with recurrent fetal losses.
Beyan
Cengiz
C
Department of Hematology, Gulhane Military Medical Academy, Etlik, 06010 Ankara, Turkey. cbeyan@yahoo.com
Kaptan
Kürşat
K
Ifran
Ahmet
A
D000026:Abortion, Habitual / Q000097:blood* / Q000209:etiology*; D000244:Adenosine Diphosphate / Q000494:pharmacology; D000328:Adult; D001791:Blood Platelet Disorders / Q000097:blood / Q000150:complications; D003094:Collagen / Q000494:pharmacology; D004837:Epinephrine / Q000494:pharmacology; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D010974:Platelet Aggregation / Q000187:drug effects; D011247:Pregnancy
D000244:Adenosine Diphosphate; D003094:Collagen; D004837:Epinephrine