Why men's hearts break: cardiovascular effects of sex steroids.
Coronary artery disease (CAD) mortality differs in men and women, leading to the speculation that differences in sex steroids contribute to risk. Controlled clinical trials have shown that estrogen replacement is not cardioprotective in certain women, and recent cross-sectional studies associate low testosterone with a greater incidence of CAD in men. Testosterone has demonstrated effects on insulin resistance, obesity, myocardium, coagulation, inflammation, vasodilation, and endothelial function. Imbalance of sex steroids contributes to adverse cardiac effects in men.
Choi
Brian G
BG
The Zena and Michael A. Wiener Cardiovascular Institute, The Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1030, New York, NY 10029, USA.
McLaughlin
Mary Ann
MA
D001777:Blood Coagulation / Q000502:physiology; D003324:Coronary Artery Disease / Q000453:epidemiology / Q000209:etiology* / Q000473:pathology; D004730:Endothelium, Vascular / Q000502:physiology / Q000503:physiopathology; D012739:Gonadal Steroid Hormones / Q000097:blood / Q000502:physiology*; D006801:Humans; D007006:Hypogonadism / Q000378:metabolism; D007249:Inflammation / Q000150:complications; D008297:Male; D009206:Myocardium / Q000473:pathology; D009765:Obesity / Q000097:blood / Q000150:complications; D013739:Testosterone / Q000097:blood / Q000494:pharmacology; D013927:Thrombosis / Q000097:blood / Q000209:etiology
D012739:Gonadal Steroid Hormones; D013739:Testosterone