Pesticides and metals induced Parkinson's disease: involvement of free radicals and oxidative stress.
Environmental factors play a critical role in the etiology of Parkinson's disease in genetically susceptible aged individuals. Epidemiological findings have suggested the role of pesticides and metals in the onset and progression of Parkinson's disease. Environmental chemicals such as pesticides and metals induced PD animal models are established and evidences obtained from biochemical; molecular and behavioral studies indicated significant contribution of oxidative stress in PD. In this article, an update on the role of free radicals and antioxidants in the onset and progression of pesticides and metals induced PD has been discussed.
Singh
C
C
Industrial Toxicology Research Centre, Mahatma Gandhi Marg, Lucknow, UP, India. singhchetnaitrc@rediffmail.com
Ahmad
I
I
Kumar
A
A
D000818:Animals; D005609:Free Radicals / Q000378:metabolism*; D006801:Humans; D008670:Metals / Q000506:poisoning*; D008954:Models, Biological; D018384:Oxidative Stress / Q000502:physiology*; D010300:Parkinson Disease / Q000209:etiology / Q000378:metabolism* / Q000503:physiopathology; D010575:Pesticides / Q000506:poisoning*
D005609:Free Radicals; D008670:Metals; D010575:Pesticides