[Application of autologous platelet-rich gel to refractory chronic diabetic cutaneous ulcers].
OBJECTIVE
To review and evaluate the clinical application of autologous platelet-rich gel (APG) in refractory chronic diabetic cutaneous ulcers.


METHODS
The latest literature was extensively reviewed, and the potential mechanism of APG for healing diabetic cutaneous ulcers was discussed.


RESULTS
APG accelerated the ulcer healing, especially in healing the refractory diabetic cutaneous ulcers, and the high-level growth factors from the platelet releasate were thought to be the major potential mechanism of the APG action.


CONCLUSIONS
APG can promote the healing of refractory chronic diabetic cutaneous ulcers. Topical haemotherapy with APG may be considered an adjuvant treatment of a multidisciplinary process and may be useful to the effective therapy of cutaneous ulcers.
Yuan
Nanbing
N
Diabetic Foot Care Center, Department of Endocrinology, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P. R. China.
Ran
Xingwu
X
D002908:Chronic Disease; D019992:Databases as Topic; D048909:Diabetes Complications; D005782:Gels / Q000737:chemistry; D006133:Growth Substances / Q000502:physiology / Q000627:therapeutic use; D006801:Humans; D053657:Platelet-Rich Plasma; D012883:Skin Ulcer / Q000209:etiology / Q000628:therapy*; D014945:Wound Healing / Q000502:physiology*
D005782:Gels; D006133:Growth Substances