title: Proton beam therapy for hepatocellular carcinoma with inferior vena cava tumor thrombus: report of three cases.
abstract: Three patients with hepatocellular carcinoma (HCC) and inferior vena cava tumor thrombus (IVCTT) were treated using proton beam therapy at the University of Tsukuba, Japan. A total dose of 50-70 Gy in 10-35 fractions was given to the primary tumor and IVCTT. All the patients survived for more than 1 year from the beginning of proton beam therapy (13-55 months) and no treatment-related toxicity of grade 3 or higher was observed. These cases suggest that proton beam therapy is safe and effective for patients with HCC associated with IVCTT.
authors.affiliation: Proton Medical Research Center, University of Tsukuba, Tennoudai, Tsukuba, Ibaraki, Japan. mizumoto@pmrc.tsukuba.ac.jp
authors.forename: Masashi
authors.initials: M
authors.lastname: Mizumoto
authors.forename: Koichi
authors.initials: K
authors.lastname: Tokuuye
authors.forename: Shinji
authors.initials: S
authors.lastname: Sugahara
authors.forename: Masaharu
authors.initials: M
authors.lastname: Hata
authors.forename: Nobuyoshi
authors.initials: N
authors.lastname: Fukumitsu
authors.forename: Takayuki
authors.initials: T
authors.lastname: Hashimoto
authors.forename: Kayoko
authors.initials: K
authors.lastname: Ohnishi
authors.forename: Keiko
authors.initials: K
authors.lastname: Nemoto
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Ohara
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Matsuzaki
authors.forename: Eriko
authors.initials: E
authors.lastname: Tohno
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Akine
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000000981:diagnostic imaging / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged; D009360:Neoplastic Cells, Circulating / Q000528:radiation effects*; D061766:Proton Therapy; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014682:Vena Cava, Inferior; D011522:Protons
chemical_list: D011522:Protons