title: [Autologous mononuclear bone marrow cell transplantation by intracoronary route for patients with ischemic heart disease: observation of 2-years follow-up].
abstract: OBJECTIVE
  To investigate the long-term effect and safety of intracoronary autologous bone marrow mononuclear cell (BMMC) transplantation in patients with ischemic heart disease (IHD).
  
  
  METHODS
  Seventy-six patients with IHD, 26 patients with acute myocardial infarction (AMI) and 26 patients with chronic ischemic heart failure (CIHF), underwent routine treatment plus intracoronary autologous BMMC transplantation, and 24 patients, including 10 patients with AMI and 14 patients with CIHF underwent routine treatment as controls. Autologous BMMC transplantation was performed via a balloon catheter placed into the infarct-related artery during balloon dilatation by high pressure infusion to occlude the artery, which was performed 6 - 8 times for 2 minutes each with 2-minute interval or via a balloon catheter without occluding the infarct-related artery. Follow-up was conducted for 2 years.
  
  
  RESULTS
  The surgery was safety without major periprocedural complications. There were no other new arrhythmias found by Holter recorder during the 2-years follow-up. In the AMI patients receiving BNNC transplantation, the left ventricular ejection fraction (LVEF) 1 and 2 years later increased by 5.79% (P < 0.05), 3.79% (P > 0.05) respectively; but there was no change in left ventricular end diastolic volume (LVEDV) and left ventricular end systolic volume (LVESV). The LVEF 1 and 2 years later of the control group increased by 8.8% and 9.2% respectively (both P < 0.01) and the LVESV 1 and 2 years later decreased by 20.4% and 27.8% respectively (both P < 0.05), the myocardium defect area 2 years later was not significantly different from that 3 months later. The heart function of the control group became markedly worse.
  
  
  CONCLUSIONS
  Autologous BMMC intracoronary transplantation is safe and effective, especially in patients with CIHF.
authors.affiliation: Department of Cardiology, General Hospital of Naval General Hospital of the Chinese People's Liberation Army, Beijing 100037, China.
authors.forename: Lian-Ru
authors.initials: LR
authors.lastname: Gao
authors.forename: Zhi-Guo
authors.initials: ZG
authors.lastname: Wang
authors.forename: Hai-Tao
authors.initials: HT
authors.lastname: Tian
authors.forename: Zhi-Ming
authors.initials: ZM
authors.lastname: Zhu
authors.forename: Yü-Xing
authors.initials: YX
authors.lastname: Fei
authors.forename: Hong-Tao
authors.initials: HT
authors.lastname: Xu
authors.forename: Yu
authors.initials: Y
authors.lastname: Chen
authors.forename: Jia-Rui
authors.initials: JR
authors.lastname: Zhu
authors.forename: Sheng
authors.initials: S
authors.lastname: He
authors.forename: Ning-Kun
authors.initials: NK
authors.lastname: Zhang
authors.forename: Qing-Ai
authors.initials: QA
authors.lastname: Ding
authors.forename: Ye
authors.initials: Y
authors.lastname: Yang
mesh_terms: D000368:Aged; D001854:Bone Marrow Cells / Q000166:cytology; D016026:Bone Marrow Transplantation / Q000379:methods*; D003331:Coronary Vessels / Q000601:surgery; D005500:Follow-Up Studies; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000166:cytology / Q000637:transplantation; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000601:surgery*; D014182:Transplantation, Autologous