title: Technology transfer from the science of medicine to the real world: the potential role played by artificial adaptive systems.
abstract: The author describes a refiguration of medical thought that originates from nonlinear dynamics and chaos theory. The coupling of computer science and these new theoretical bases coming from complex systems mathematics allows the creation of "intelligent" agents capable of adapting themselves dynamically to problems of high complexity: the artificial neural networks (ANNs). ANNs are able to reproduce the dynamic interaction of multiple factors simultaneously, allowing the study of complexity; they can also draw conclusions on an individual basis and not as average trends. These tools can allow a more efficient technology transfer from the science of medicine to the real world, overcoming many obstacles responsible for the present translational failure. They also contribute to a new holistic vision of the human subject person, contrasting the statistical reductionism that tends to squeeze or even delete the single subject, sacrificing him to his group of belongingness. A remarkable contribution to this individual approach comes from fuzzy logic, according to which there are no sharp limits between opposite things, such as wealth and disease. This approach allows one to partially escape from the probability theory trap in situations where it is fundamental to express a judgement based on a single case and favor a novel humanism directed to the management of the patient as an individual subject person.
authors.affiliation: Bracco SpA, Milan, Italy. enzo.grossi@bracco.com
authors.forename: Enzo
authors.initials: E
authors.lastname: Grossi
mesh_terms: D000465:Algorithms; D001185:Artificial Intelligence; D035843:Biomedical Research; D003658:Decision Making, Computer-Assisted; D004059:Diffusion of Innovation; D019317:Evidence-Based Medicine; D017143:Fuzzy Logic; D006808:Humanism; D006801:Humans; D019300:Medical Errors; D013677:Medical Laboratory Science; D017711:Nonlinear Dynamics; D010686:Philosophy, Medical; D016032:Randomized Controlled Trials as Topic; D018581:Technology Transfer