title: Synthesis, spectral studies and antibacterial activity of novel macrocyclic Co(II) compounds.
abstract: Ten novel macrocyclic Co(II) compounds have been synthesized by treating four N(4) and six N(2)O(2) donor macrocycles with cobalt chloride in methanol. These compounds were characterized by elemental, IR, (1)H, (13)C NMR, mass, electronic spectral analysis, molar conductance and magnetic susceptibility measurements. Thermal behavior of these compounds has been studied by the thermogravimetric analysis. An octahedral geometry has been proposed for all of these complexes. All the macrocycles and macrocyclic Co(II) compounds along with existing antibacterial drugs were screened for antibacterial activity against Gram +ve and Gram -ve bacteria. All these compounds were found to be more active when compared to streptomycin and ampicillin.
authors.affiliation: Department of Chemistry, Kakatiya University, Warangal, India.
authors.forename: P Muralidhar
authors.initials: PM
authors.lastname: Reddy
authors.forename: Adapa V S S
authors.initials: AV
authors.lastname: Prasad
authors.forename: Kanne
authors.initials: K
authors.lastname: Shanker
authors.forename: Vadde
authors.initials: V
authors.lastname: Ravinder
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D002247:Carbon Isotopes; D004553:Electric Conductivity; D004583:Electrons; D047028:Macrocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008280:Magnetics; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D013055:Spectrophotometry, Infrared; D013696:Temperature
chemical_list: D000900:Anti-Bacterial Agents; D002247:Carbon Isotopes; D047028:Macrocyclic Compounds