title: Heart failure with mitral valve regurgitation due to primary hyperoxaluria type 1: case report with review of the literature.
abstract: Primary hyperoxaluria type I (PH I) is a rare recessive autosomal disorder characterized by systemic calcium oxalate depositions, that results in renal failure and systemic oxalosis. We report a 38-year-old male with cardiac oxalosis, a severe complication of PHI, presenting with an infiltrative cardiomyopathy, secondary heart failure and severe mitral regurgitation, necessitating surgical repair to allow combined liver-kidney transplantation. We discuss pathogenesis, diagnostics and therapy of this clinical entity by reviewing literature.
authors.affiliation: Department of Cardiology, University Hospital Ghent, Ghent, Belgium. Lucvandriessche@hotmail.com
authors.forename: Luc
authors.initials: L
authors.lastname: Van Driessche
authors.forename: Annemieke
authors.initials: A
authors.lastname: Dhondt
authors.forename: Johan
authors.initials: J
authors.lastname: De Sutter
mesh_terms: D000328:Adult; D009202:Cardiomyopathies / Q000209:etiology; D004452:Echocardiography; D006333:Heart Failure / Q000209:etiology*; D019918:Heart Valve Prosthesis Implantation; D006801:Humans; D006960:Hyperoxaluria, Primary / Q000150:complications*; D007676:Kidney Failure, Chronic / Q000209:etiology / Q000473:pathology / Q000628:therapy; D008297:Male; D008944:Mitral Valve Insufficiency / Q000000981:diagnostic imaging / Q000209:etiology* / Q000601:surgery; D006435:Renal Dialysis; D014262:Tricuspid Valve Insufficiency / Q000000981:diagnostic imaging / Q000209:etiology / Q000601:surgery