[One-night psychotic episode during topiramate treatment in connection with an acute febrile infection].
Topiramate is an anticonvulsant which has been used more and more in recent years in psychiatry as well. The undesirable effects that have been observed remain relatively mild under conditions of slow titration. Psychotic symptoms have been described in connection with the use of topiramate in individual cases, however. It is not known which concomitant circumstances favour the appearance of this side-effect, though. This is a report about a psychotic attack that happened for the first time and lasted for one night in a borderline patient who was treated with topiramate 250 mg/day shortly after the start of a febrile infection. After the infection had gone, topiramate was given again and titrated to 300 mg/day. No further psychotic symptoms were observed.
Nickel
Marius
M
Klinik für Psychosomatik und Psychotherapie, Medizinische Universität Graz. m.nickel@klinik-badaussee.at
D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use / Q000633:toxicity*; D001883:Borderline Personality Disorder / Q000175:diagnosis / Q000188:drug therapy* / Q000523:psychology; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005335:Fever of Unknown Origin / Q000150:complications*; D005632:Fructose / Q000031:analogs & derivatives* / Q000627:therapeutic use / Q000633:toxicity; D006212:Hallucinations / Q000139:chemically induced / Q000175:diagnosis / Q000523:psychology; D006801:Humans; D008297:Male; D011605:Psychoses, Substance-Induced / Q000175:diagnosis* / Q000523:psychology; D012141:Respiratory Tract Infections / Q000150:complications*; D000077236:Topiramate
D000927:Anticonvulsants; D000077236:Topiramate; D005632:Fructose