title: Usefulness of multi-parameter opiates-amphetamines-cocainics analysis in hair of drug users for the evaluation of an abuse profile by means of LC-APCI-MS-MS.
abstract: The report presents a segmental hair analysis for the retrospective multi-parameter evaluation of drugs of abuse including opioids, cocainics and amphetamines. The analysis was carried out with the use of liquid chromatography atmospheric pressure chemical ionization tandem mass spectrometry (LC-APCI-MS-MS). The authors have evaluated the differences in the contents of particular opiates in the hair as related to the origin of a sample taken from Polish drug users taking "Polish heroin", and also from heroin abusers from Western European countries taking "Western heroin". The results indicate distinct differences in the 6-MAM concentration values in the Polish and foreigners, suggesting that the foreigners take products containing high concentrations of heroin and the Polish take the poppy product "compote" characterized by its variable and low heroin content. An additional argument for a different abuse profile in the Polish and Western drug users is found in the presence of cocaine detected in hair samples originating from the latter, while cocaine is much less frequently detected in Polish drug users.
authors.affiliation: Department of Toxicology, Institute of Forensic Medicine, Collegium Medicum, Jagiellonian University, 16 Grzegórzecka St., Kraków, Poland. mpklys@cyf-kr.edu.pl
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Kłys
authors.forename: Sebastian
authors.initials: S
authors.lastname: Rojek
authors.forename: Joanna
authors.initials: J
authors.lastname: Kulikowska
authors.forename: Edward
authors.initials: E
authors.lastname: Bozek
authors.forename: Mariusz
authors.initials: M
authors.lastname: Scisłowski
mesh_terms: D000662:Amphetamines / Q000032:analysis*; D002853:Chromatography, Liquid / Q000379:methods*; D003042:Cocaine / Q000032:analysis*; D006197:Hair / Q000737:chemistry*; D006801:Humans; D018847:Opioid Peptides / Q000032:analysis*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D015813:Substance Abuse Detection / Q000379:methods*; D019966:Substance-Related Disorders / Q000175:diagnosis*; D053719:Tandem Mass Spectrometry / Q000379:methods*
chemical_list: D000662:Amphetamines; D018847:Opioid Peptides; D003042:Cocaine