Enforcing Ostwald's rule of stages: isolation of paracetamol forms III and II.
We have been able to isolate and study the polymorphic form III of paracetamol using a specially designed methodology. Our work represents the first report of a reproducible, reliable route to form III. This has been an outstanding problem for over quarter of a century. Our method may be applicable to the isolation of metastable polymorphs of other compounds.
Burley
Jonathan C
JC
University Chemical Laboratory, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, England. jburley@dmu.ac.uk
Duer
Melinda J
MJ
Stein
Robin S
RS
Vrcelj
Ranko M
RM
D000082:Acetaminophen / Q000737:chemistry / Q000302:isolation & purification*; D002152:Calorimetry, Differential Scanning / Q000379:methods; D020650:Combinatorial Chemistry Techniques / Q000379:methods; D003460:Crystallization; D009682:Magnetic Resonance Spectroscopy / Q000295:instrumentation / Q000379:methods; D008855:Microscopy, Electron, Scanning / Q000379:methods; D033362:Powder Diffraction / Q000379:methods; D015203:Reproducibility of Results; D013678:Technology, Pharmaceutical / Q000295:instrumentation / Q000379:methods*; D044366:Transition Temperature; D014961:X-Ray Diffraction / Q000379:methods
D000082:Acetaminophen