Involvement of nitric oxide in spatial memory deficits in status epilepticus rats.
Status epilepticus (SE) is associated with a significant risk of cognitive impairment, and the increase of nitric oxide (NO) releasing has been reported during SE. We investigated the effects of neuronal nitric oxide synthase (nNOS) inhibitor, 7-nitroindazole (7-NI) and inducible nitric oxide synthase (iNOS) inhibitor, aminoguanidine (AG), on spatial performance of rats in the Morris water maze. Treatment with 7-NI, but not with AG, improved the performance of rats after SE not only in acquisition of the task but also in probe test. Furthermore, the level of SE-induced malondialdehyde (MDA), end product of lipid peroxidation, was significantly decreased only in animals receiving 7-NI injection. Taken together, the results of the present study provided evidence that the NO pathway contributed to oxidative stress after SE, and nNOS/NO pathway may underlie one of the potential mechanisms contributing to SE-induced spatial memory deficits.
Liu
Zhao Wei
ZW
Key Lab of Bioactive Materials, Ministry of Education and College of Life Science, Nankai University, Tianjin 300071, China.
Zhang
Tao
T
Yang
Zhuo
Z
D000818:Animals; D005979:Glutathione Peroxidase / Q000378:metabolism; D006146:Guanidines / Q000494:pharmacology; D006624:Hippocampus / Q000502:physiology; D007191:Indazoles / Q000494:pharmacology; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D018782:Maze Learning / Q000187:drug effects; D008569:Memory Disorders / Q000503:physiopathology*; D009569:Nitric Oxide / Q000502:physiology*; D052248:Nitric Oxide Synthase Type I / Q000037:antagonists & inhibitors; D052247:Nitric Oxide Synthase Type II / Q000037:antagonists & inhibitors; D010862:Pilocarpine; D051381:Rats; D017208:Rats, Wistar; D013226:Status Epilepticus / Q000139:chemically induced / Q000503:physiopathology / Q000523:psychology*; D013482:Superoxide Dismutase / Q000378:metabolism
D006146:Guanidines; D007191:Indazoles; D010862:Pilocarpine; D009569:Nitric Oxide; D008315:Malondialdehyde; D005979:Glutathione Peroxidase; D052248:Nitric Oxide Synthase Type I; D052247:Nitric Oxide Synthase Type II; C496318:Nos2 protein, rat; D013482:Superoxide Dismutase; C004479:pimagedine; C080122:7-nitroindazole