title: Synthesis and characterization of functional elastomeric poly(ester amide) co-polymers.
abstract: A new family of random co-poly(ester amides)s (co-PEAs) having reactive pendant functional carboxylic acid groups were synthesized by co-polycondensation of di-p-toluenesulfonic acid salts of bis-(L-alpha-amino acid (L-leucine and/or L-phenylalanine)) alpha,omega-alkylene diesters with active diesters of dicarboxylic acids using di-p-toluenesulfonic acid salt of L-lysine benzyl ester as a co-monomer. The lateral benzyl ester groups in the L-lysine segment of co-PEAs were subsequently transformed into free COOH groups by catalytic hydrogenolysis using Pd black as a catalyst. The co-PEA-based polyacids obtained, as well as the original co-PEA having lateral benzyl ester groups were characterized by standard methods. In vitro biodegradation studies in the presence of hydrolases like alpha-chymotrypsin and lipase showed significant enzymatic-catalyzed biodegradation of these co-PEAs. These co-PEA-based polyacids were used for covalent attachment of iminoxyl radicals (4-amino-TEMPO) and in vitro biodegradation of 4-aminoTEMPO attached polymer was studied along with releasing kinetic of iminoxyl radical.
authors.affiliation: Research Centre for Medical Polymers and Biomaterials, Georgian Technical University, P.O. Box 24, Tbilisi 0179, Georgia, USA.
authors.forename: G
authors.initials: G
authors.lastname: Jokhadze
authors.forename: M
authors.initials: M
authors.lastname: Machaidze
authors.forename: H
authors.initials: H
authors.lastname: Panosyan
authors.forename: C C
authors.initials: CC
authors.lastname: Chu
authors.forename: R
authors.initials: R
authors.lastname: Katsarava
mesh_terms: D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry; D000596:Amino Acids / Q000737:chemistry; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry; D020724:Elastomers; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011091:Polyesters / Q000138:chemical synthesis* / Q000737:chemistry; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D000577:Amides; D000596:Amino Acids; D001672:Biocompatible Materials; D020724:Elastomers; D011091:Polyesters; D011108:Polymers; C036925:elastomeric polymer