Endpoints for lymphatic filariasis programs.
In 2000, annual mass administration of diethlycarbamazine and albendazole began in Leogane Commune, Haiti, to interrupt transmission of lymphatic filariasis (LF). After 5 years of treatment, microfilaremia, antigenemia, and mosquito infection rates were significantly reduced, but LF transmission was not interrupted. These finding have implications for other LF elimination programs.
Grady
Caroline A
CA
Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA.
de Rochars
Madsen Beau
MB
Direny
Abdel N
AN
Orelus
Jean Nicolas
JN
Wendt
Joyanna
J
Radday
Jeanne
J
Mathieu
Els
E
Roberts
Jacquelin M
JM
Streit
Thomas G
TG
Addiss
David G
DG
Lammie
Patrick J
PJ
D015766:Albendazole / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D000818:Animals; D004049:Diethylcarbamazine / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D004605:Elephantiasis, Filarial / Q000188:drug therapy / Q000453:epidemiology* / Q000469:parasitology / Q000517:prevention & control*; D005369:Filaricides / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D006078:Government Programs / Q000592:standards*; D006205:Haiti / Q000453:epidemiology; D006801:Humans; D008842:Microfilariae / Q000187:drug effects; D015995:Prevalence; D015397:Program Evaluation; D014958:Wuchereria bancrofti / Q000187:drug effects
D005369:Filaricides; D015766:Albendazole; D004049:Diethylcarbamazine