title: 2-Cycloalkyl phenoxyacetic acid CRTh2 receptor antagonists.
abstract: High throughput screening identified a phenoxyacetic acid scaffold as a novel CRTh2 receptor antagonist chemotype, which could be optimised to furnish a compound with functional potency for inhibition of human eosinophil shape change and oral bioavailability in the rat.
authors.affiliation: Global Discovery Chemistry, Novartis Institutes of Biomedical Research, Horsham Research Centre, Wimblehurst Road, Horsham, West Sussex RH12 5AB, UK. david.sandham@novartis.com
authors.forename: David A
authors.initials: DA
authors.lastname: Sandham
authors.forename: Clive
authors.initials: C
authors.lastname: Aldcroft
authors.forename: Urs
authors.initials: U
authors.lastname: Baettig
authors.forename: Lucy
authors.initials: L
authors.lastname: Barker
authors.forename: David
authors.initials: D
authors.lastname: Beer
authors.forename: Gurdip
authors.initials: G
authors.lastname: Bhalay
authors.forename: Zarin
authors.initials: Z
authors.lastname: Brown
authors.forename: Gerald
authors.initials: G
authors.lastname: Dubois
authors.forename: David
authors.initials: D
authors.lastname: Budd
authors.forename: Louise
authors.initials: L
authors.lastname: Bidlake
authors.forename: Emma
authors.initials: E
authors.lastname: Campbell
authors.forename: Brian
authors.initials: B
authors.lastname: Cox
authors.forename: Brian
authors.initials: B
authors.lastname: Everatt
authors.forename: David
authors.initials: D
authors.lastname: Harrison
authors.forename: Catherine J
authors.initials: CJ
authors.lastname: Leblanc
authors.forename: Jodie
authors.initials: J
authors.lastname: Manini
authors.forename: Rachael
authors.initials: R
authors.lastname: Profit
authors.forename: Rowan
authors.initials: R
authors.lastname: Stringer
authors.forename: Katy S
authors.initials: KS
authors.lastname: Thompson
authors.forename: Katharine L
authors.initials: KL
authors.lastname: Turner
authors.forename: Morris F
authors.initials: MF
authors.lastname: Tweed
authors.forename: Christoph
authors.initials: C
authors.lastname: Walker
authors.forename: Simon J
authors.initials: SJ
authors.lastname: Watson
authors.forename: Steven
authors.initials: S
authors.lastname: Whitebread
authors.forename: Jennifer
authors.initials: J
authors.lastname: Willis
authors.forename: Gareth
authors.initials: G
authors.lastname: Williams
authors.forename: Caroline
authors.initials: C
authors.lastname: Wilson
mesh_terms: D000085:Acetates / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D001682:Biological Availability; D004804:Eosinophils / Q000187:drug effects; D006801:Humans; D051381:Rats; D011971:Receptors, Immunologic / Q000037:antagonists & inhibitors*; D011982:Receptors, Prostaglandin / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship
chemical_list: D000085:Acetates; D011971:Receptors, Immunologic; D011982:Receptors, Prostaglandin; C036293:prostaglandin D2 receptor; C415326:phenoxyacetic acid