title: Mutagenicity study of weeds and common plants used in traditional medicine and for animal feed.
abstract: Mutagenicity and antimutagenicity potentials were tested using Ames' test in crude distilled water and absolute ethanol extracts from the stems and leaves of Peperomia pellucida (Linn.) Kunth, Eichhornia crassipes Solms, Colocasia esculenta Schott and Brachiaria mutica (Forssk.) Stapf, and the stems of Musa sapientum Linn. No mutagenic effect was found in any of the 10 mg/plate crude extracts of these plants for either TA98 or TA100 of Salmonella typhimurium, in a direct test and a mutagenic induced test by S-9 mix. Both distilled water and absolute ethanol extract of 0.5-10 mg/plate B. mutica showed strong antimutagenicity to AFB1, B(a)P and 4NQO in two tester strains. Ethanol extract of 0.1-0.5 mg/plate C. esculenta also showed antimutagenicity to AFB1, B(a)P and 4NQO in two tester strains, but the 0.5-10 mg/plate water extract had an antimutagenic effect only for B(a)P in TA98. The ethanol extracts of 5 mg/plate B. mutica and 0.5 mg/plate C. esculenta are cytotoxic, as indicated by their partial killing effect.
authors.affiliation: Department of Tropical Nutrition and Food Science, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
authors.forename: Apanchanid
authors.initials: A
authors.lastname: Thepouyporn
authors.forename: Karunee
authors.initials: K
authors.lastname: Kwanbunjan
authors.forename: Somchai
authors.initials: S
authors.lastname: Pooudong
authors.forename: Supranee
authors.initials: S
authors.lastname: Changbumrung
mesh_terms: D000821:Animal Feed; D016587:Antimutagenic Agents / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D008519:Medicine, Traditional; D009152:Mutagenicity Tests; D009153:Mutagens / Q000494:pharmacology* / Q000633:toxicity*; D010944:Plants / Q000737:chemistry / Q000633:toxicity*; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics; D013785:Thailand
chemical_list: D016587:Antimutagenic Agents; D000972:Antineoplastic Agents, Phytogenic; D009153:Mutagens