Electron density analyses of opioids: a comparative study.
The electron densities of five morphine related molecules (codeine, diprenorphine, naltrexone in the neutral and protonated states, and dextromethorphan) were determined from high-resolution X-ray diffraction experiments (Mo Kalpha and synchrotron primary radiation) at low temperature and CCD area detection techniques. Bond topological analyses were applied, and a partitioning of the molecules into atomic regions making use of Bader's zero flux surfaces yielded atomic volumes and charges. The obtained atom and bonding properties were compared to the results of a previous experimental study of morphine and to theoretical calculations. Experimental and theoretical properties for all chemically equivalent bonds agree within an uncertainty range as is otherwise seen for different theoretical calculations. Hence, the transferability of chemically equivalent submolecular properties, being a key issue of the atoms in molecules (AIM) theory, has been verified experimentally in this class of chemically related molecules. On the other hand, topological differences could clearly be verified in regions with different chemical environments. Electron density differences between the two forms of naltrexone were examined and made visible in an extended region around the nitrogen atom which is once in a neutral state and once in a positively charged state.
Scheins
Stephan
S
Institute for Chemistry and Biochemistry/Crystallography, Free University of Berlin, Fabeckstrasse 36a, 14195 Berlin, Germany.
Messerschmidt
Marc
M
Morgenroth
Wolfgang
W
Paulmann
Carsten
C
Luger
Peter
P
D000701:Analgesics, Opioid / Q000737:chemistry*; D003061:Codeine / Q000737:chemistry; D003080:Cold Temperature; D003915:Dextromethorphan / Q000737:chemistry; D004174:Diprenorphine / Q000737:chemistry; D004583:Electrons; D008958:Models, Molecular; D009020:Morphine / Q000737:chemistry*; D009271:Naltrexone / Q000737:chemistry; D014961:X-Ray Diffraction
D000701:Analgesics, Opioid; D004174:Diprenorphine; D009271:Naltrexone; D003915:Dextromethorphan; D009020:Morphine; D003061:Codeine