Leishmania MAP kinases--familiar proteins in an unusual context.
Mitogen-activated protein kinases are well-known mediators of signal transduction of higher eukaryotes regulating important processes like proliferation, differentiation, stress response and apoptosis. In Leishmania, the typical three-tiered module of MAP kinase signal transduction pathways is present. However, typical activators like cell surface receptors and substrates such as RNA polymerase II transcription factors are missing. Here, I describe the set of 15 putative mitogen-activated protein kinases encoded in the Leishmania genome and discuss their potential function.
Wiese
Martin
M
Bernhard Nocht Institute for Tropical Medicine, Parasitology Section, Bernhard-Nocht-Strasse 74, D-20359 Hamburg, Germany. martin.wiese@bni-hamburg.de
D000595:Amino Acid Sequence; D000818:Animals; D005786:Gene Expression Regulation; D007891:Leishmania / Q000201:enzymology* / Q000235:genetics / Q000648:ultrastructure; D020928:Mitogen-Activated Protein Kinases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D008969:Molecular Sequence Data; D010802:Phylogeny; D015800:Protozoan Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism
D015800:Protozoan Proteins; D020928:Mitogen-Activated Protein Kinases