title: Artificial reduction in transepidermal water loss improves skin barrier function.
abstract: BACKGROUND
  Artificial reduction of abnormal transepidermal water loss (TEWL) is considered to improve skin diseases associated with a defective barrier function. Treatment of the skin with moisturizers is also known to influence skin barrier function. Whether or not differences in occlusion between creams contribute to their effects on the skin barrier function is unknown.
  
  
  OBJECTIVE
  To investigate the long-term effects of a semipermeable membrane on the skin barrier function in normal skin. In addition, the occlusive properties of two creams were studied.
  
  
  METHODS
  The study was randomized, controlled and evaluator-blind using measurement of TEWL and skin susceptibility to sodium lauryl sulphate as indicators of skin barrier function.
  
  
  RESULTS
  Coating of the skin with a silicone membrane for 23 h per day for 3 weeks improved skin barrier function, whereas no significant changes were found after using the membrane for 8 h per day.
  
  
  CONCLUSIONS
  Differences between creams in terms of their effect on skin barrier function cannot be solely explained by their occlusive properties.
authors.affiliation: ACO HUD NORDIC AB, Research and Development, Box 622, SE-194 26 Upplands Väsby, Sweden.
authors.forename: I
authors.initials: I
authors.lastname: Buraczewska
authors.forename: U
authors.initials: U
authors.lastname: Broström
authors.forename: M
authors.initials: M
authors.lastname: Lodén
mesh_terms: D000287:Administration, Topical; D000328:Adult; D004643:Emollients / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008297:Male; D010328:Patch Tests / Q000379:methods / Q000706:statistics & numerical data; D012828:Silicones / Q000008:administration & dosage / Q000494:pharmacology; D012869:Skin Absorption / Q000187:drug effects*; D012967:Sodium Dodecyl Sulfate / Q000494:pharmacology*; D013501:Surface-Active Agents / Q000494:pharmacology*; D014870:Water Loss, Insensible / Q000502:physiology*
chemical_list: D004643:Emollients; D012828:Silicones; D013501:Surface-Active Agents; D012967:Sodium Dodecyl Sulfate