title: Early continuous venovenous hemodialysis in dialysis-dependent patients after cardiac surgery: safety and efficacy.
abstract: OBJECTIVE
  The present study assessed the safety and efficacy of continuous venovenous hemodialysis (CVVHD) early after cardiac surgery.
  
  
  METHODS
  Retrospective database and medical record review.
  
  
  METHODS
  University teaching hospital.
  
  
  METHODS
  Forty-five dialysis-dependent patients who underwent cardiac surgery with cardiopulmonary bypass.
  
  
  METHODS
  CVVHD was begun postoperatively after confirmation of hemostasis, irrespective of circulatory status. In the last 5 patients, the ratio of extravascular lung water (EVLW) to intrathoracic blood volume (ITBV) was measured using a single-indicator thermodilution catheter and compared with patients of normal renal function undergoing cardiac surgery.
  
  
  RESULTS
  CVVHD was started at 4 hours after ICU admission. The maximum decrease in blood pressure within 60 minutes after initiation of CVVHD was 11 +/- 9 mmHg in the unstable hemodynamics group (defined as patients who required continuous intravenous adrenaline or intra-aortic balloon pump on admission to the ICU [n = 15]) and 7 +/- 8 mmHg in the stable hemodynamics group (n = 30, not significant). Circulatory status and oxygenation improved significantly 12 hours after CVVHD initiation in the unstable hemodynamics group. Blood volume from the chest tube did not increase after CVVHD. Early mortality (2.2%) was lower than that reported previously. The EVLW/ITBV ratio after ICU admission in dialysis-dependent patients was significantly higher than in patients with normal renal function.
  
  
  CONCLUSIONS
  Early CVVHD after cardiac surgery in dialysis-dependent patients was safe and effective. There was no associated increased postoperative bleeding or hemodynamic instability. Fluid removal improved respiratory status, particularly in patients requiring circulatory assistance, and overall early morality rates were lower that those previously published.
authors.affiliation: Department of Anesthesiology and Intensive Care Medicine, Osaka City University Medical School, Osaka, Japan. nksuji@msic.med.osaka-cu.ac.jp
authors.forename: Masato
authors.initials: M
authors.lastname: Nakasuji
authors.forename: Shinichi
authors.initials: S
authors.lastname: Nishi
authors.forename: Kae
authors.initials: K
authors.lastname: Nakasuji
authors.forename: Naoya
authors.initials: N
authors.lastname: Hamaoka
authors.forename: Kazutoshi
authors.initials: K
authors.lastname: Ikeshita
authors.forename: Akira
authors.initials: A
authors.lastname: Asada
mesh_terms: D000368:Aged; D001794:Blood Pressure; D001810:Blood Volume; D006348:Cardiac Surgical Procedures; D005260:Female; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis / Q000009:adverse effects* / Q000379:methods*; D012189:Retrospective Studies