Wounds: an overview of the role of oxygen.
We sought to review the role of oxygen in wound healing, with an emphasis on the role tissue oximetry has played in clinical advances in the care of patients with wounds. Oxygen is required for wound healing. Hypoxia sufficient to impair healing is common in wounds, frequently resulting from sympathetically induced vasoconstriction. Correction or prevention of vasoconstriction, as well as provision of increased inspired oxygen in well-perfused patients, has been shown in randomized, controlled clinical trials to improve wound outcomes. Our understanding of the role of oxygen in wound healing has been fueled by tissue oximetry. Advances in technology will lead to further advances in the management of patients with wounds.
Hopf
Harriet W
HW
Department of Anesthesiology, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA. harriet.hopf@hsc.utah.edu
Rollins
Mark D
MD
D000818:Animals; D002986:Clinical Trials as Topic; D006801:Humans; D008365:Manometry / Q000379:methods; D008954:Models, Biological; D010092:Oximetry / Q000379:methods; D010100:Oxygen / Q000378:metabolism*; D010477:Perfusion; D011817:Rabbits; D013696:Temperature; D013997:Time Factors; D014662:Vasoconstrictor Agents / Q000494:pharmacology; D014945:Wound Healing
D014662:Vasoconstrictor Agents; D010100:Oxygen