Tools for efficient high-throughput synthesis.
Here, we detail the major developments in methods and techniques that are applicable to high-throughput synthesis that have evolved over the past five years, with an emphasis on the combination of microwave-based synthesis with techniques such as polymer-assisted purification and immobilized reagents and catalysts. Other aspects, such as automation, miniaturization and flow-based synthesis, are also presented as approaches that can be used for the rapid discovery and optimization of small organic molecules.
Chighine
Alessandra
A
School of Chemistry, Combinatorial Centre of Excellence, University of Edinburgh, West Mains Road, Edinburgh, UK.
Sechi
Gianluca
G
Bradley
Mark
M
D000818:Animals; D002384:Catalysis; D004353:Drug Evaluation, Preclinical / Q000295:instrumentation* / Q000379:methods*; D006801:Humans; D007202:Indicators and Reagents; D008872:Microwaves; D004364:Pharmaceutical Preparations / Q000138:chemical synthesis*
D007202:Indicators and Reagents; D004364:Pharmaceutical Preparations