Adjunctive fast repetitive transcranial magnetic stimulation in depression.
The place of repetitive transcranial magnetic stimulation (rTMS) in the treatment of depression remains unclear. In this sham-controlled study we determined the efficacy and acceptability offast, left frontal rTMS given three times a week over 4-6 weeks to 29 patients with depression (79% treatment-resistant). The procedure was generally well tolerated and more effective than sham treatment (55 v.77% responding, P<0.05), with improvement maintained to 12 weeks. This therapy could be a useful addition to available treatments but further research is needed to determine the optimum treatment parameters.
Anderson
Ian M
IM
Neuroscience and Psychiatry Unit, University of Manchester, Manchester, UK. ian.anderson@manchester.ac.uk
Delvai
Nicola A
NA
Ashim
Bettadapura
B
Ashim
Sindhu
S
Lewin
Cherry
C
Singh
Vineet
V
Sturman
Daniel
D
Strickland
Paul L
PL
D000328:Adult; D003866:Depressive Disorder / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D050781:Transcranial Magnetic Stimulation / Q000379:methods*; D016896:Treatment Outcome