title: Antidiabetic copper(II)-picolinate: impact of the first transition metal in the metallopicolinate complexes.
abstract: In order to examine the effect of metallopicolinate complexes with first transition metals and develop complexes that are more active than an insulinomimetic leading compound such as oxovanadium(IV)-picolinate complex, VO(pa)2, 10 metallopicolinate complexes were prepared, and their in vitro insulinomimetic and in vivo antidiabetic activities were evaluated. The in vitro activity was estimated by determining the inhibitory effects of these complexes on free fatty acid release from isolated rat adipocytes treated with epinephrine. Among the complexes, Cu(pa)2, and Mn(pa)3 exhibited higher activity than their respective metal ions and better activity than VO(pa)2. Since Cu(pa)2 was non-toxic in the cultured rat hepatic M cells, this complex was given streptozotocin (STZ)-induced type 1-like diabetic mice by single intraperitoneal injection, and found that this complex exhibited a higher hypoglycemic effect than the VO(pa)2 complex. Based on these results, we propose that Cu(pa)2 may be a potent alternative antidiabetic agent.
authors.affiliation: Department of Analytical and Bioinorganic Chemistry, Kyoto Pharmaceutical University, 5 Nakauchi-cho, Misasagi, Yamashina-ku, Kyoto 607-8414, Japan.
authors.forename: Naoko
authors.initials: N
authors.lastname: Yasumatsu
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Yoshikawa
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Adachi
authors.forename: Hiromu
authors.initials: H
authors.lastname: Sakurai
mesh_terms: D017667:Adipocytes / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002470:Cell Survival / Q000187:drug effects; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003300:Copper / Q000737:chemistry*; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D007003:Hypoglycemia / Q000188:drug therapy / Q000473:pathology; D020128:Inhibitory Concentration 50; D008297:Male; D010848:Picolinic Acids / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats
chemical_list: D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D010848:Picolinic Acids; D003300:Copper; C030614:picolinic acid