Mast cell infiltration is a favourable prognostic factor in diffuse large B-cell lymphoma.
Previous studies indicate that the inflammatory response in diffuse large B-cell lymphomas (DLBCL) is important for the clinical outcome. Mast cells are key regulators in this response; we investigated whether the number of tryptase-positive mast cells is correlated with clinical outcome. Patients with many mast cells had a significantly better event-free survival (EFS) compared to those with few mast cells (P < 0.03 in both germinal centre (GC) and non-GC DLBCL. This supports the idea that the infiltration of mast cells is a reflection of the host inflammatory response and is related to a favourable outcome.
Hedström
Gustaf
G
Department of Oncology, Radiology and Clincial Immunology, Uppsala University, Uppsala, Sweden. gustaf.hedstrom@onkologi.uu.se
Berglund
Mattias
M
Molin
Daniel
D
Fischer
Marie
M
Nilsson
Gunnar
G
Thunberg
Ulf
U
Book
Majlis
M
Sundström
Christer
C
Rosenquist
Richard
R
Roos
Göran
G
Erlanson
Martin
M
Amini
Rose-Marie
RM
Enblad
Gunilla
G
D000368:Aged; D015415:Biomarkers / Q000032:analysis; D002465:Cell Movement; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D016403:Lymphoma, Large B-Cell, Diffuse / Q000276:immunology*; D008297:Male; D008407:Mast Cells / Q000201:enzymology / Q000473:pathology*; D008875:Middle Aged; D011379:Prognosis; D016016:Proportional Hazards Models; D018709:Statistics, Nonparametric; D016019:Survival Analysis; D053802:Tryptases / Q000032:analysis
D015415:Biomarkers; D053802:Tryptases