title: Matrix metalloproteinases in kidney disease progression and repair: a case of flipping the coin.
abstract: Matrix metalloproteinases (MMPs) have pleiotropic enzymatic actions that go far beyond degradation of extracellular matrix. Both the multiplicity of their targets and the complexity of their regulation account for a variety of biological effects. In renal diseases, MMP effects may be different and/or opposite during the different phases of the pathology evolution. The major challenge with future therapeutic interventions using MMP inhibitors remains how to accomplish temporal and spatial control of their activity without flipping the coin.
authors.affiliation: INSERM Unit 702, and Université Pierre et Marie Curie, Paris, France. pierre.ronco@tnn.aphp.fr
authors.forename: Pierre
authors.initials: P
authors.lastname: Ronco
authors.forename: Brigitte
authors.initials: B
authors.lastname: Lelongt
authors.forename: Rémi
authors.initials: R
authors.lastname: Piedagnel
authors.forename: Christos
authors.initials: C
authors.lastname: Chatziantoniou
mesh_terms: D000818:Animals; D018450:Disease Progression; D004791:Enzyme Inhibitors / Q000627:therapeutic use*; D005544:Forecasting; D006801:Humans; D007674:Kidney Diseases / Q000201:enzymology / Q000235:genetics / Q000503:physiopathology*; D061965:Matrix Metalloproteinase Inhibitors; D020782:Matrix Metalloproteinases / Q000145:classification / Q000235:genetics / Q000378:metabolism / Q000502:physiology*
chemical_list: D004791:Enzyme Inhibitors; D061965:Matrix Metalloproteinase Inhibitors; D020782:Matrix Metalloproteinases