title: Fosamprenavir/ritonavir plus tenofovir does not affect amprenavir pharmacokinetics: no effect of tenofovir.
abstract: The effect of tenofovir disoproxil fumarate (TDF) in combination with two boosted fosamprenavir regimens on amprenavir pharmacokinetic parameters was assessed in this prospective phase I crossover study with 30 healthy volunteers. The co-administration of TDF 300 mg once a day with fosamprenavir/ritonavir 1400/200 mg or 1400/100 mg once a day has no effect on the pharmacokinetics of amprenavir and results in non-significant increases of ritonavir pharmacokinetic parameters, suggesting that no dose modification is necessary when combining fosamprenavir/ritonavir with TDF.
authors.affiliation: Therapia GmbH, Berlin, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Kurowski
authors.forename: Ravi K
authors.initials: RK
authors.lastname: Walli
authors.forename: Antje
authors.initials: A
authors.lastname: Breske
authors.forename: Guido
authors.initials: G
authors.lastname: Kruse
authors.forename: Hartmut
authors.initials: H
authors.lastname: Stocker
authors.forename: Norbert
authors.initials: N
authors.lastname: Banik
authors.forename: Heinz
authors.initials: H
authors.lastname: Richter
authors.forename: Dago
authors.initials: D
authors.lastname: Mazur
mesh_terms: D000225:Adenine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D044966:Anti-Retroviral Agents / Q000627:therapeutic use*; D019540:Area Under Curve; D002219:Carbamates / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D018592:Cross-Over Studies; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005663:Furans; D017320:HIV Protease Inhibitors / Q000008:administration & dosage; D018023:HIV Seronegativity; D006801:Humans; D008297:Male; D010755:Organophosphates / Q000008:administration & dosage*; D063065:Organophosphonates / Q000008:administration & dosage*; D011446:Prospective Studies; D018894:Reverse Transcriptase Inhibitors / Q000008:administration & dosage; D019438:Ritonavir / Q000008:administration & dosage*; D013449:Sulfonamides / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D000068698:Tenofovir
chemical_list: D044966:Anti-Retroviral Agents; D002219:Carbamates; D005663:Furans; D017320:HIV Protease Inhibitors; D010755:Organophosphates; D063065:Organophosphonates; D018894:Reverse Transcriptase Inhibitors; D013449:Sulfonamides; C095108:amprenavir; D000068698:Tenofovir; D000225:Adenine; D019438:Ritonavir; C426859:fosamprenavir