Structure elucidation of thermal degradation products of amlodipine.
Thermal degradation of amlodipine base causes intramolecular reactions affording three cyclic products, referred to as AMLDEG-I, AMLDEG-II, and AMLDEG-III, respectively. AMLDEG-I is a cyclized product formed by intramolecular elimination of ammonia from amlodipine. AMLDEG-II is a positional isomer of AMLDEG-I. AMLDEG-III is also intramolecular cyclisation product. The three degradation products were isolated by column chromatography and characterized by FT-IR and 1H and 13C NMR spectroscopy data. The AMLDEG-III was crystallized and its structure was solved by single crystal X-ray diffraction (SXRD).
Lakshmi Devi
A Siva
AS
Analytical Research and Development, Matrix Laboratories Ltd., Jeedimetla, Hyderabad, India-500055, India. sivalakshmi@matrixlabsindia.com
Srinivasa Rao
Y
Y
Satish
M
M
Jyothi
G
G
Babu Rao
K
K
Omdutt
T
T
D017311:Amlodipine / Q000737:chemistry*; D003500:Cyclization; D006358:Hot Temperature; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D014961:X-Ray Diffraction
D017311:Amlodipine