Acute ventricular and aortic thrombosis post chemotherapy.
We present a rare case of spontaneous arterial thrombosis in a 42-year-old male with an acute history of bilateral lower limb pain and weakness. The previous day he had received the first cycle of cisplatin-based chemotherapy for oesophageal adenocarcinoma (T2/3N0/M0). Computed tomography (CT) and angiography showed extensive abdominal aortic thrombus in a native non-aneurysmal or grossly atheromatous aorta with separate thrombus in the left ventricle. We suggest that poor left ventricular function, a hypercoaguable state secondary to malignancy and cisplatin based chemotherapy may have induced severe arterial and intra-cardiac thrombosis.
Morlese
J F
JF
Royal Free Hospital, Pond Street, London, UK. james.bell@royalfree.nhs.uk
Jeswani
T
T
Beal
I
I
Wylie
P
P
Bell
J
J
D000208:Acute Disease; D000230:Adenocarcinoma / Q000188:drug therapy; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D001018:Aortic Diseases / Q000139:chemically induced* / Q000000981:diagnostic imaging; D004938:Esophageal Neoplasms / Q000188:drug therapy; D017809:Fatal Outcome; D006331:Heart Diseases / Q000139:chemically induced* / Q000000981:diagnostic imaging; D006352:Heart Ventricles; D006801:Humans; D008297:Male; D013927:Thrombosis / Q000139:chemically induced* / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed