title: Effect of acidic degradation products of poly(lactic-co-glycolic)acid on the apatite-forming ability of poly(lactic-co-glycolic)acid-siloxane nanohybrid material.
abstract: The effect of poly(lactic-co-glycolic) acid (PLGA) degradation products on the apatite-forming ability of a PLGA-siloxane nanohybrid material were investigated. Two PLGA copolymer compositions with low and high degradability were used in the experiment. The PLGA-siloxane nanohybrid materials were synthesized by end-capping PLGA with acid end-groups using 3-isocyanatopropyl triethoxysilane following the sol-gel reaction with calcium nitrate tetrahydrate. Two nanohybrid materials that had different degradability were exposed to simulated body fluid (SBF) for 1-28 days at 36.5 degrees C. The low degradable PLGA hybrid showed apatite-forming ability within 3 days of incubation while the high degradable one did not within 28 days testing period. The results were explained in terms of the acidity of the PLGA degradation products, which could directly influence on the apatite dissolution.
authors.affiliation: Department of Dental Biomaterials Science and Dental Research Institute, School of Dentistry, Seoul National University, Seoul 110-749, Korea. rhee1213@snu.ac.ke
authors.forename: Sang-Hoon
authors.initials: SH
authors.lastname: Rhee
authors.forename: Seung Jin
authors.initials: SJ
authors.lastname: Lee
mesh_terms: D001031:Apatites / Q000138:chemical synthesis / Q000737:chemistry*; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry*; D001826:Body Fluids / Q000737:chemistry*; D017610:Calcium Compounds / Q000737:chemistry; D006016:Glycolates / Q000138:chemical synthesis / Q000737:chemistry*; D006358:Hot Temperature; D006863:Hydrogen-Ion Concentration; D019344:Lactic Acid; D008422:Materials Testing; D009566:Nitrates / Q000737:chemistry; D011100:Polyglycolic Acid; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D012821:Silanes / Q000737:chemistry; D012833:Siloxanes / Q000138:chemical synthesis / Q000737:chemistry*; D013997:Time Factors
chemical_list: C492426:(3-isocyanatopropyl) triethoxysilane; D001031:Apatites; D001672:Biocompatible Materials; D017610:Calcium Compounds; D006016:Glycolates; D009566:Nitrates; D012821:Silanes; D012833:Siloxanes; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; C059948:calcium nitrate