title: Intron 4 VNTR of endothelial nitric oxide synthase (eNOS) gene and diabetic retinopathy in type 2 patients in southern India.
abstract: A 27-bp variable number tandem repeat (VNTR) in intron 4 of endothelial nitric oxide synthase (eNOS) gene has been associated with the risk for developing diabetic retinopathy (DR) in various ethnic populations. Hundred and eighty seven patients with retinopathy (cases; DR+) and 188 patients without retinopathy (controls: DR-) from southern India who had type 2 diabetes mellitus (T2DM) for more than 10 years, were included in the study. We could neither find significant allelic association with clinical severity of DR nor with macular edema. Our results suggest lack of association of intron 4 VNTR of eNOS gene with DR in southern India.
authors.affiliation: SN ONGC Department of Genetics and Molecular Biology, Vision Research Foundation, Chennai, India.
authors.forename: Satagopan
authors.initials: S
authors.lastname: Uthra
authors.forename: Rajiv
authors.initials: R
authors.lastname: Raman
authors.forename: Bickol N
authors.initials: BN
authors.lastname: Mukesh
authors.forename: R
authors.initials: R
authors.lastname: Padmaja Kumari
authors.forename: Pradeep G
authors.initials: PG
authors.lastname: Paul
authors.forename: Praveena
authors.initials: P
authors.lastname: Lakshmipathy
authors.forename: Perumal
authors.initials: P
authors.lastname: Gnanamoorthy
authors.forename: Tarun
authors.initials: T
authors.lastname: Sharma
authors.forename: Catherine A
authors.initials: CA
authors.lastname: McCarty
authors.forename: Govindasamy
authors.initials: G
authors.lastname: Kumaramanickavel
mesh_terms: D000483:Alleles; D015331:Cohort Studies; D003924:Diabetes Mellitus, Type 2 / Q000201:enzymology / Q000235:genetics*; D003930:Diabetic Retinopathy / Q000201:enzymology / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D007194:India; D007438:Introns; D008297:Male; D008875:Middle Aged; D018598:Minisatellite Repeats / Q000235:genetics*; D052250:Nitric Oxide Synthase Type III / Q000235:genetics*; D011110:Polymorphism, Genetic; D012307:Risk Factors
chemical_list: D052250:Nitric Oxide Synthase Type III