Bupropion interference with immunoassays for amphetamines and LSD.
A 50-year-old male patient suddenly had lost consciousness, although he had previously been healthy. On arrival at hospital seizures arose. The authors investigated a urine sample of the patient, and performed toxicological drug screening with immunochemical Cloned Enzyme Donor Immunoassay (CEDIA) assays. Positive findings for amphetamines and LSD could not be confirmed. Using gas chromatography/mass spectrometry (GC/MS), and liquid chromatography/mass spectrometry (LC/MS), the authors identified bupropion, a drug used to aid in smoking cessation, as the interfering compound, which may cause false-positive results for amphetamines and LSD using the CEDIA assays.
Vidal
Christian
C
Klinische Chemie, Medizinische Hochschule Hannover, Hannover, Germany. vidal.christian@mh-hannover.de
Skripuletz
Thomas
T
D000662:Amphetamines / Q000652:urine; D018687:Antidepressive Agents, Second-Generation / Q000009:adverse effects* / Q000494:pharmacology; D016642:Bupropion / Q000009:adverse effects* / Q000494:pharmacology; D004347:Drug Interactions; D005189:False Positive Reactions; D006801:Humans; D008238:Lysergic Acid Diethylamide / Q000652:urine; D008297:Male; D008875:Middle Aged; D012640:Seizures / Q000139:chemically induced*; D019966:Substance-Related Disorders / Q000652:urine*
D000662:Amphetamines; D018687:Antidepressive Agents, Second-Generation; D016642:Bupropion; D008238:Lysergic Acid Diethylamide