[Clinical analysis of infectious complications following abdominal cluster transplantation].
OBJECTIVE
To investigate the characteristic and management of postoperative infection in abdominal cluster transplantation.


METHODS
Preliminary experience of two cases of abdominal cluster transplantation including small intestine was reviewed.


RESULTS
Combination of five immunosuppressive agents based on tacrolimus was used. Severe Gram-negative bacillus infections occurred. The majority of invasive fungal infections was due to Candida species. Cytomegalovirus (CMV) infection increased monocytes and caused eosinopenia and an inversion of the CD4(+) to CD8(+) cell ratio in recipient I, and human CMV matrix proteins pp71 (CMV-pp71) was detected and identified in bile by PCR. Microabscesses in liver transplant biopsies were presented.


CONCLUSIONS
Infectious complications after cluster transplantation were complicated. Strategies to optimize the immunity suppression protocol and early diagnosis and treatment will be important to reduce infection after abdominal cluster transplantation.
Chen
Hui-xing
HX
Department of General Surgery, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Yin
Lu
L
Peng
Cheng-hong
CH
Zhou
Guang-wen
GW
Shen
Bai-yong
BY
Chen
Gui-ming
GM
Chen
Chun-qiu
CQ
Zhou
Hui-jiang
HJ
Li
Hong-wei
HW
D000328:Adult; D001424:Bacterial Infections / Q000188:drug therapy / Q000209:etiology; D003586:Cytomegalovirus Infections / Q000188:drug therapy / Q000209:etiology / Q000821:virology; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use; D007421:Intestine, Small / Q000637:transplantation*; D016031:Liver Transplantation / Q000009:adverse effects / Q000379:methods; D008297:Male; D009894:Opportunistic Infections / Q000188:drug therapy / Q000209:etiology*; D016377:Organ Transplantation / Q000009:adverse effects* / Q000379:methods; D011183:Postoperative Complications / Q000188:drug therapy / Q000209:etiology*; D012189:Retrospective Studies
D007166:Immunosuppressive Agents