title: Antiproliferative cardenolides of an Elaeodendron sp. from the Madagascar rain forest(1).
abstract: Bioassay-guided fractionation of an ethanol extract obtained from the Madagascar plant Elaeodendron sp. led to the isolation of two new cardenolides, elaeodendrosides T and U (1 and 2). The structures of the new compounds were elucidated using 1D and 2D NMR experiments and mass spectrometry. Compounds 1, 3, 4, and 5 showed significant antiproliferative activity against A2780 human ovarian cancer cells with IC50 values of 0.085, 0.019, 0.19, and 0.10 microM, respectively, while compounds 2 and 6 were less active.
authors.affiliation: Department of Chemistry, M/C 0212, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA.
authors.forename: Shugeng
authors.initials: S
authors.lastname: Cao
authors.forename: Peggy J
authors.initials: PJ
authors.lastname: Brodie
authors.forename: James S
authors.initials: JS
authors.lastname: Miller
authors.forename: Fidy
authors.initials: F
authors.lastname: Ratovoson
authors.forename: Martin W
authors.initials: MW
authors.lastname: Callmander
authors.forename: Sennen
authors.initials: S
authors.lastname: Randrianasolo
authors.forename: Etienne
authors.initials: E
authors.lastname: Rakotobe
authors.forename: Vincent E
authors.initials: VE
authors.lastname: Rasamison
authors.forename: Edward M
authors.initials: EM
authors.lastname: Suh
authors.forename: Karen
authors.initials: K
authors.lastname: TenDyke
authors.forename: David G I
authors.initials: DG
authors.lastname: Kingston
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002298:Cardenolides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D029753:Celastraceae / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D008270:Madagascar; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010946:Plants, Medicinal / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D002298:Cardenolides; C521657:elaeodendroside T; C521656:elaeodendroside U