title: [Polymorphism of 12 Y-STR loci in Guangzhou Han population and its application in forensic medicine].
abstract: OBJECTIVE
  To investigate the allele frequency distribution, gene diversity and haplotype diversity of 12 Y-specific short tandem repeats (STR) in Guangzhou Han population and evaluate their forensic application.
  
  
  METHODS
  Twelve Y-STR loci in 401 unrelated male Han individuals in Guangzhou were amplified with PowerPlex(R) Y System, and the PCR products were detected with 3100 Genetic Analyzer.
  
  
  RESULTS
  The data of allele distribution and gene diversity of the 12 Y-STR loci were obtained from these individuals. A total of 398 haplotypes were observed and the overall haplotype diversity for the 12 Y-STR loci was 0.99997. The DNA samples of 13 different species of animals were amplified and no specific products were observed. Different tissues from the same individual exhibited the same Y-STR haplotype.
  
  
  CONCLUSIONS
  The 12 Y-STR loci exhibit high genetic polymorphism and are of important value in understanding of the human origin, individual identification for mixed male/female DNA samples and paternity identification.
authors.affiliation: Institute of Forensic Medicine, Southern Medical University, Guangzhou 510515, China. liuchaogz@21cn.com
authors.forename: Chao
authors.initials: C
authors.lastname: Liu
authors.forename: Ling
authors.initials: L
authors.lastname: Chen
authors.forename: Xiao-hui
authors.initials: XH
authors.lastname: Chen
authors.forename: Chang-hui
authors.initials: CH
authors.lastname: Liu
authors.forename: Hui-jun
authors.initials: HJ
authors.lastname: Wang
mesh_terms: D002681:China; D041322:Chromosomes, Human, Y / Q000235:genetics*; D005554:Forensic Medicine / Q000379:methods*; D005787:Gene Frequency; D014644:Genetic Variation; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats / Q000235:genetics*; D011110:Polymorphism, Genetic; D044382:Population Groups