A follow-up study of Nordic multiple sclerosis candidate gene regions.
In this study, the results from three Nordic linkage disequilibrium screens in multiple sclerosis (MS) were investigated, in a new sample set of 314 Nordic MS trios from Denmark, Norway, Sweden and Iceland. Among 30 non-HLA and two HLA microsatellite markers individually genotyped, eight markers displayed distorted transmission with uncorrected P-value<0.05, ranked in this order: D6S2443 (6p21.32, HLA class II) (P corrected=0.01), D2S2201 (2p24), D19S552 (19q13), D3S3584 (3q21), D17S975 (17q11), D1S2627 (1p22), D6S273 (6p21.33, HLA class III) and D12S1051 (12q23). These non-HLA regions need further investigation as possible MS candidate gene regions in our population.
Datta
P
P
Danish Multiple Sclerosis Research Centre, Copenhagen, Denmark.
Harbo
H F
HF
Ryder
L P
LP
Akesson
E
E
Benedikz
J
J
Celius
E G
EG
Andersen
O
O
Myhr
K-M
KM
Sandberg-Wollheim
M
M
Hillert
J
J
Svejgaard
A
A
Sorensen
P S
PS
Spurkland
A
A
Oturai
A
A
D005500:Follow-Up Studies; D005787:Gene Frequency; D005820:Genetic Testing; D005838:Genotype; D006680:HLA Antigens / Q000235:genetics*; D006801:Humans; D007055:Iceland / Q000453:epidemiology; D015810:Linkage Disequilibrium; D018895:Microsatellite Repeats; D009103:Multiple Sclerosis / Q000208:ethnology* / Q000235:genetics*; D012537:Scandinavian and Nordic Countries / Q000453:epidemiology
D006680:HLA Antigens