A novel DRB1*04 allele.
Discovery of the novel DRB1*0464 allele is described. This allele contains a nucleotide substitution in codon 13 that changes the amino acid histidine coded for in all other DRB1*04 alleles to tyrosine. This allele was found in a parent and one child of a North American Caucasian family with the haplotype: A*03, B*07, DRB1*0464, DRB4*0103, DQB1*0301.
Endres
R O
RO
HLA Laboratory, Blood Systems Laboratories, 2424 W. Erie Drive, Tempe, AZ, USA. rendres@bloodsystems.org
Wetzsteon
P J
PJ
Stein
J
J
Norman
D J
DJ
D000483:Alleles; D019943:Amino Acid Substitution; D001483:Base Sequence; D002648:Child; D003062:Codon; D017931:DNA Primers; D005091:Exons; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006239:Haplotypes; D006650:Histocompatibility Testing; D006801:Humans; D016030:Kidney Transplantation; D008875:Middle Aged; D008969:Molecular Sequence Data; D009656:North America; D017422:Sequence Analysis, DNA; D014443:Tyrosine / Q000378:metabolism; D044465:White People / Q000235:genetics
D003062:Codon; D017931:DNA Primers; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; D014443:Tyrosine