A role for "self" in T-cell activation.
The mechanisms by which alphabeta T-cells are selected in the thymus and then recognize peptide MHC (pMHC) complexes in the periphery remain an enigma. Recent work particularly with respect to quantification of T-cell sensitivity and the role of self-ligands in T-cell activation has provided some important clues to the details of how TCR signaling might be initiated. Here, we highlight recent experimental data that provides insights into the initiation of T-cell activation and also discuss the main controversies and uncertainties in this area.
Krogsgaard
Michelle
M
Department of Pathology and NYU Cancer Institute, NYU School of Medicine, New York, NY 10016, USA. michelle.krogsgaard@med.nyu.edu
Juang
Jeremy
J
Davis
Mark M
MM
D000938:Antigen-Presenting Cells / Q000276:immunology*; D016827:CD8 Antigens / Q000276:immunology; D006801:Humans; D008198:Lymph Nodes / Q000276:immunology; D008213:Lymphocyte Activation / Q000276:immunology*; D010455:Peptides / Q000276:immunology; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D013950:Thymus Gland / Q000276:immunology
D016827:CD8 Antigens; D010455:Peptides