Scaffold mediated regulation of MAPK signaling and cytoskeletal dynamics: a perspective.
Cell migration is critical for many physiological processes and is often misregulated in developmental disorders and pathological conditions including cancer and neurodegeneration. MAPK signaling and the Rho family of proteins are known regulators of cell migration that exert their influence on cellular cytoskeleton during cell adhesion and migration. Here we review data supporting the view that localized ERK signaling mediated through recently identified scaffold proteins may regulate cell migration.
Pullikuth
Ashok K
AK
Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, 1901 Perdido Street, New Orleans, LA 70112, USA. apulli@lsuhsc.edu
Catling
Andrew D
AD
D000199:Actins / Q000378:metabolism; D000818:Animals; D002448:Cell Adhesion / Q000502:physiology; D002465:Cell Movement / Q000502:physiology; D003599:Cytoskeleton / Q000502:physiology*; D006801:Humans; D020928:Mitogen-Activated Protein Kinases / Q000502:physiology*; D008954:Models, Biological; D015398:Signal Transduction; D020741:rho GTP-Binding Proteins / Q000502:physiology
D000199:Actins; D020928:Mitogen-Activated Protein Kinases; D020741:rho GTP-Binding Proteins