title: Pathophysiology of pulmonary arterial hypertension.
abstract: The mechanisms leading to elevations in precapillary pulmonary vascular resistance are complex and likely involve multiple pathways, but the histopathologic sequelae of these processes are restricted to a few findings, primarily neoangiogenesis, intimal and smooth muscle proliferation, vasoconstriction, and/or in situ thrombosis. Regardless of the etiology of pulmonary hypertension, abnormalities in endothelial function are often observed and likely play a central role in mediating structural changes.
authors.affiliation: Section of Pulmonary/Critical Care Medicine, Ochsner Foundation Clinic, Jefferson, USA.
authors.forename: Suma
authors.initials: S
authors.lastname: Jain
authors.forename: Hector
authors.initials: H
authors.lastname: Ventura
authors.forename: Ben
authors.initials: B
authors.lastname: deBoisblanc
mesh_terms: D006801:Humans; D006976:Hypertension, Pulmonary / Q000503:physiopathology*