Visual function in regenerating teleost retina following surgical lesioning.
Regeneration of the teleost retina following surgical extirpation of 25% to 100% of the neural retina was investigated in goldfish (Carrasius auratus) and sunfish (Lepomis cyanellus). The retina will regenerate following removal of up to 95% of the neural retina, however complete extirpation prevented regeneration. Visual sensitivity was assessed by examining components of the electroretinogram (ERG) and the dorsal light reflex (DLR) during regeneration. B-wave amplitudes in the experimental eyes increased throughout the study and central connections were reestablished as indicated by the progressive improvement in the dorsal light reflex. The recovery of visual function was closely correlated with retinal regeneration. Visual recovery progressed more slowly than following complete cytotoxic destruction of the mature retina (Mensinger & Powers, 1999) because the surgery removed a large number of the pluripotent cell population and restricted the number and distribution of regenerating foci.
Mensinger
Allen F
AF
Vision Research Center and Department of Psychology, Vanderbilt University, Nashville, Tennessee, USA. amensing@d.umn.edu
Powers
Maureen K
MK
D000818:Animals; D004307:Dose-Response Relationship, Radiation; D004596:Electroretinography / Q000379:methods; D006054:Goldfish / Q000033:anatomy & histology / Q000502:physiology; D008027:Light; D009416:Nerve Regeneration / Q000502:physiology*; D010473:Perciformes / Q000033:anatomy & histology / Q000502:physiology; D010775:Photic Stimulation; D020127:Recovery of Function / Q000502:physiology; D012018:Reflex / Q000502:physiology; D012160:Retina / Q000293:injuries* / Q000473:pathology / Q000502:physiology*; D014785:Vision, Ocular / Q000502:physiology*