title: Pulmonary manifestations of Pyoderma gangrenosum.
abstract: BACKGROUND
  Pyoderma gangrenosum is an uncommon ulcerative cutaneous disorder. Extracutaneous localizations are rare. Respiratory system involvement has been described in a few cases, but the pulmonary features reported were highly variable.
  
  
  METHODS
  We report two cases of patients with Pyoderma gangrenosum combining cutaneous and pulmonary manifestations. One case presented multiple nodular lesions, some with cavitation. The underlying disease was varicella-zoster virus infection. The second presented pneumonitis with bronchiolar micronodules.
  
  
  CONCLUSIONS
  Few cases have reported Pyoderma gangrenosum with pulmonary involvement, which appears to be manifested mainly as nodules or interstitial lung disease. The principal differential diagnosis is Wegener's granulomatosis.
authors.affiliation: Service de pneumologie et immuno-allergologie, Hôpital universitaire Calmette, Lille. bacharchahine@hotmail.com
authors.forename: Bachar
authors.initials: B
authors.lastname: Chahine
authors.forename: Cecile
authors.initials: C
authors.lastname: Chenivesse
authors.forename: Isabelle
authors.initials: I
authors.lastname: Tillie-Leblond
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Delaporte
authors.forename: Arnaud
authors.initials: A
authors.lastname: Scherpereel
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Grignet
authors.forename: André-Bernard
authors.initials: AB
authors.lastname: Tonnel
mesh_terms: D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000627:therapeutic use; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000627:therapeutic use; D001706:Biopsy; D003937:Diagnosis, Differential; D005260:Female; D014890:Granulomatosis with Polyangiitis / Q000175:diagnosis; D006801:Humans; D008168:Lung / Q000473:pathology; D008171:Lung Diseases / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D017563:Lung Diseases, Interstitial / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000209:etiology / Q000473:pathology; D008297:Male; D011014:Pneumonia / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000209:etiology / Q000473:pathology; D011239:Prednisolone / Q000008:administration & dosage / Q000627:therapeutic use; D011658:Pulmonary Fibrosis / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000209:etiology; D017511:Pyoderma Gangrenosum / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology; D013902:Radiography, Thoracic; D012867:Skin / Q000473:pathology; D003074:Solitary Pulmonary Nodule / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000209:etiology / Q000473:pathology; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones; D000893:Anti-Inflammatory Agents; D011239:Prednisolone