title: Imaging voltage-dependent cell motions with heterodyne Mach-Zehnder phase microscopy.
abstract: We describe a heterodyne Mach-Zehnder interferometric microscope capable of quantitative phase imaging of biological samples with subnanometer sensitivity and frame rates up to 10 kHz. We use the microscope to image cultured neurons and measure nanometer-scale voltage-dependent motions in cells expressing the membrane motor protein prestin.
authors.affiliation: G.R. Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA. minwah@mit.edu
authors.forename: Christopher
authors.initials: C
authors.lastname: Fang-Yen
authors.forename: Seungeun
authors.initials: S
authors.lastname: Oh
authors.forename: Yongkeun
authors.initials: Y
authors.lastname: Park
authors.forename: Wonshik
authors.initials: W
authors.lastname: Choi
authors.forename: Sen
authors.initials: S
authors.lastname: Song
authors.forename: H Sebastian
authors.initials: HS
authors.lastname: Seung
authors.forename: Ramachandra R
authors.initials: RR
authors.lastname: Dasari
authors.forename: Michael S
authors.initials: MS
authors.lastname: Feld
mesh_terms: D000818:Animals; D027321:Anion Transport Proteins / Q000378:metabolism; D002460:Cell Line; D002465:Cell Movement; D004563:Electrochemistry / Q000379:methods; D004594:Electrophysiology / Q000379:methods; D004867:Equipment Design; D006801:Humans; D007368:Interferometry / Q000379:methods*; D008858:Microscopy, Phase-Contrast / Q000379:methods*; D008954:Models, Biological; D009474:Neurons / Q000378:metabolism; D051381:Rats; D012680:Sensitivity and Specificity; D000076988:Sulfate Transporters; D013997:Time Factors; D014162:Transfection
chemical_list: D027321:Anion Transport Proteins; C498719:SLC26A5 protein, human; D000076988:Sulfate Transporters