title: Some elements for a revision of the americium reference biokinetic model.
abstract: The interpretation of individual activity measurement after a contamination by 241Am or its parent nuclide 241Pu is based on the reference americium (Am) biokinetic model published by the International Commission on Radiological Protection in 1993 [International Commission on Radiological Protection. Age-dependent doses to members of the public from intake of radionuclides: Part 2 Ingestion dose coefficients. ICRP Publication 67. Ann. ICRP 23(3/4) (1993)]. The authors analysed the new data about Am biokinetics reported afterwards to propose an update of the current model. The most interesting results, from the United States Transuranium and Uranium Registries post-mortem measurement database [Filipy, R. E. and Russel, J. J. The United States Transuranium and Uranium Registries as sources for actinide dosimetry and bioeffects. Radiat. Prot. Dosim. 105(1-4), 185-187 (2003)] and the long-term follow-up of cases of inhalation intake [Malátová, I., Foltánová, S., Becková, V., Filgas, R., Pospísilová, H. and Hölgye, Z. Assessment of occupational doses from internal contamination with 241Am. Radiat. Prot. Dosim. 105(1-4), 325-328 (2003)], seemed to show that the current model underestimates the retention in the massive soft tissues and overestimates the retention in the skeleton and the late urinary excretion. However, a critical review of the data demonstrated that all were not equally reliable and suggested that only a slight revision of the model, possibly involving a change in the balance of activity between massive soft tissues, cortical and trabecular bone surfaces, may be required.
authors.affiliation: IRSN--Institute for Radiological Protection and Nuclear Safety, Laboratory of Internal Dose Assessment, IRSN/DRPH/SDI/LEDI, B.P. 17, F-92262 Fontenay-aux-Roses Cedex, France. eric.blanchardon@irsn.fr
authors.forename: E
authors.initials: E
authors.lastname: Blanchardon
authors.forename: R W
authors.initials: RW
authors.lastname: Leggett
authors.forename: K F
authors.initials: KF
authors.lastname: Eckerman
mesh_terms: D000576:Americium / Q000493:pharmacokinetics*; D001681:Biological Assay / Q000592:standards*; D001822:Body Burden; D006801:Humans; D038622:Internationality; D007700:Kinetics; D008657:Metabolic Clearance Rate; D008954:Models, Biological; D011829:Radiation Dosage; D012016:Reference Values; D012680:Sensitivity and Specificity; D014915:Whole-Body Counting / Q000592:standards*
chemical_list: D000576:Americium