title: Clinical role of 123I-IMP SPECT for the differential diagnosis of ocular malignant melanoma: a time-course analysis.
abstract: OBJECTIVE
  To evaluate the efficacy of (123)I-IMP single photon emission computed tomography (SPECT) for the diagnosis of ocular malignant melanoma (MM).
  
  
  METHODS
  Thirty-eight patients (18 males, 20 females) clinically suspected of having ocular MM were retrospectively examined in this study. The age of patients ranged from 8 to 81 years (mean 55.6 years). Twelve patients were finally diagnosed as having ocular MM. Orbital SPECT images were taken 15 min, 4 h, 24 h and 48 h after intravenous injection of 111-222 MBq (3-6 mCi) (123)I-IMP. (123)I-IMP uptake in the orbital tumor was visually evaluated as-(negative),+/-(equivocal), or+(positive). The uptake index (UI) and increase ratios (IRs) were calculated.
  
  
  RESULTS
  For visual evaluation, the accuracy of (123)I-IMP for the diagnosis of MM was 73.7% (15 min), 81.6% (4 h), 81.6% (24 h) and 86.8% (48 h). When UI and IR were calculated on both the MM and non-MM groups, the UI and IR of the MM group were significantly higher than those of the non-MM group (P<0.001). Moreover, the highest sensitivity (100%) and accuracy (94.7%) were obtained 48 h after (123)I-IMP administration when the cut-off value of UI was defined as 1.90.
  
  
  CONCLUSIONS
  This study shows that (123)I-IMP SPECT is useful for the diagnosis of ocular MM. The UI values 48 h after the injection were efficient for the differentiation between MM and non-MM lesions.
authors.affiliation: Department of Clinical Radiology, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. k-abe@radiol.med.kyushu-u.ac.jp
authors.forename: Koichiro
authors.initials: K
authors.lastname: Abe
authors.forename: Masayuki
authors.initials: M
authors.lastname: Sasaki
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Koga
authors.forename: Koichiro
authors.initials: K
authors.lastname: Kaneko
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Sawamoto
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yoshikawa
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Honda
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D003937:Diagnosis, Differential; D005134:Eye Neoplasms / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D020367:Iofetamine; D008297:Male; D008545:Melanoma / Q000000981:diagnostic imaging*; D008875:Middle Aged; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013997:Time Factors; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*
chemical_list: D019275:Radiopharmaceuticals; D020367:Iofetamine