title: CD16+ monocyte subset preferentially harbors HIV-1 and is expanded in pregnant Malawian women with Plasmodium falciparum malaria and HIV-1 infection.
abstract: In a cross-sectional study, monocyte subsets in placental, cord, and maternal peripheral blood from pregnant Malawian women with human immunodeficiency virus (HIV)-1 infection and/or malaria were analyzed. HIV-uninfected Malawian women had higher baseline proportions of CD16(+) monocytes than those reported for healthy adults in developed countries. Malaria was associated with an increase in the proportion of CD16(+) monocytes that was significant in women coinfected with HIV-1. CD16(+) monocytes expressed higher CCR5 levels than did CD14(hi)/CD16(-) monocytes and were significantly more likely to harbor HIV-1. These data suggest a role for CD16(+) monocytes in the pathogenesis of maternal malaria and HIV-1 infections.
authors.affiliation: Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia.
authors.forename: Anthony
authors.initials: A
authors.lastname: Jaworowski
authors.forename: Deborah D
authors.initials: DD
authors.lastname: Kamwendo
authors.forename: Philip
authors.initials: P
authors.lastname: Ellery
authors.forename: Secondo
authors.initials: S
authors.lastname: Sonza
authors.forename: Victor
authors.initials: V
authors.lastname: Mwapasa
authors.forename: Eyob
authors.initials: E
authors.lastname: Tadesse
authors.forename: Malcolm E
authors.initials: ME
authors.lastname: Molyneux
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Rogerson
authors.forename: Steven R
authors.initials: SR
authors.lastname: Meshnick
authors.forename: Suzanne M
authors.initials: SM
authors.lastname: Crowe
mesh_terms: D000293:Adolescent; D000328:Adult; D001769:Blood / Q000276:immunology; D003430:Cross-Sectional Studies; D004279:DNA, Viral / Q000032:analysis / Q000235:genetics; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000276:immunology* / Q000821:virology; D015497:HIV-1 / Q000302:isolation & purification*; D006801:Humans; D018950:Lipopolysaccharide Receptors / Q000032:analysis; D016778:Malaria, Falciparum / Q000150:complications* / Q000276:immunology*; D008295:Malawi; D009000:Monocytes / Q000821:virology*; D010920:Placenta / Q000276:immunology; D016133:Polymerase Chain Reaction; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000276:immunology; D015597:Pregnancy Complications, Parasitic; D019713:Receptors, CCR5 / Q000032:analysis; D017452:Receptors, IgG / Q000032:analysis*; D014470:Umbilical Cord / Q000276:immunology
chemical_list: D004279:DNA, Viral; D018950:Lipopolysaccharide Receptors; D019713:Receptors, CCR5; D017452:Receptors, IgG