CLINICAL case report: falciparum malaria with hemophagocytic syndrome.
A 30-year-old Japanese woman with falciparum malaria was hospitalized because of fever and renal failure, and prolonged anemia was identified despite the eradication of malaria parasites through anti-malaria therapy. Bone marrow aspiration revealed the presence of macrophages with hemophagocytosis, and serum interleukin (IL)-18 and tumor necrosis factor (TNF)-alpha levels were high in the anemic phase. Hemophagocytosis was confirmed for at least 3 weeks, and prolonged hemophagocytic syndrome is thought to be one of the causes of prolonged anemia in patients with falciparum malaria.
Ohnishi
Kenji
K
Department of Infectious Diseases and Tertiary Emergency Medical Center, Tokyo Metropolitan Bokutoh General Hospital, Tokyo, Japan. infection@bokutoh-hp.metro.tokyo.jp
Mitsui
Keiko
K
Komiya
Nobuhiro
N
Iwasaki
Noriaki
N
Akashi
Akiko
A
Hamabe
Yuichi
Y
D000328:Adult; D000818:Animals; D000962:Antimalarials / Q000627:therapeutic use; D005260:Female; D006801:Humans; D051359:Lymphohistiocytosis, Hemophagocytic / Q000150:complications* / Q000188:drug therapy / Q000469:parasitology; D016778:Malaria, Falciparum / Q000150:complications* / Q000188:drug therapy; D008775:Methylprednisolone / Q000627:therapeutic use; D010963:Plasmodium falciparum / Q000254:growth & development
D000962:Antimalarials; D008775:Methylprednisolone