[Large vessel vasculitis: giant cell arteritis and Takayasu arteritis].
Giant cell arteritis (GCA) and Takayasu arteritis (TA) are both chronic granulomatous vasculitis of unknown aetiology that involve large vessels. Signs and symptoms are related to the affected vessels: the primary branches of the aorta in TA and the extra-cranial branches of the external carotid artery in GCA. TA affects women under 40 of all ethnic origins with a greater prevalence in Asia, whereas GCA affects elderly of caucasian ancestry. In both diseases the diagnosis and follow up are rendered difficult by the absence of specific marker but advances in imaging technologies such as angio-MRI and PET/CT are very promising. Corticosteroids still represent the basis of treatment, most often alone in GCA and usually in association with another immunosuppressive drug in TA.
Petitpierre
Stéphanie
S
Service d'immunologie et d'allergie CHUV, 1011 Lausanne.
Bart
Pierre-Alexandre
PA
Leimgruber
Annette
A
Spertini
François
F
Prior
John
J
Spertini
F
F
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D003952:Diagnostic Imaging; D013700:Giant Cell Arteritis / Q000175:diagnosis* / Q000188:drug therapy* / Q000453:epidemiology; D006801:Humans; D013625:Takayasu Arteritis / Q000175:diagnosis* / Q000188:drug therapy* / Q000453:epidemiology
D000305:Adrenal Cortex Hormones