The chemokine system in arteriogenesis and hind limb ischemia.
Chemokines (chemotactic cytokines) are important in the recruitment of leukocytes to injured tissues and, as such, play a pivotal role in arteriogenesis and the tissue response to ischemia. Hind limb ischemia represents a complex model with arteriogenesis (collateral artery formation) occurring in tissues with normal perfusion while areas exhibiting ischemic necrosis undergo angiogenesis and skeletal muscle regeneration; monocytes and macrophages play an important role in all three of these processes. In addition to leukocyte trafficking, chemokines are produced by and chemokine receptors are present on diverse cell types, including myoblasts, endothelial, and smooth muscle cells. Thus, the chemokine system may have direct effects as well as inflammatory-mediated effects on arteriogenesis, angiogenesis, and skeletal muscle regeneration. This article reviews the complexity of the hind limb ischemia model and the role of the chemokine system in arteriogenesis and the tissue response to ischemia. Special emphasis will be placed on the roles of monocytes/macrophages and CCL2/monocyte chemotactic protein-1 (MCP-1) in these processes.
Shireman
Paula K
PK
South Texas Veterans Health Care System, Department of Surgery, Sam and Ann Barshop Institute for Longevity and Aging Studies, the University of Texas Health Science Center, San Antonio, TX, USA. Shireman@UTHSCSA.edu
D000818:Animals; D001158:Arteries / Q000378:metabolism / Q000503:physiopathology; D018932:Chemokine CCL2 / Q000378:metabolism; D018925:Chemokines / Q000378:metabolism*; D020523:Chemokines, CX3C / Q000378:metabolism; D004195:Disease Models, Animal; D006614:Hindlimb; D007249:Inflammation / Q000378:metabolism* / Q000503:physiopathology; D007511:Ischemia / Q000378:metabolism* / Q000503:physiopathology; D008264:Macrophages / Q000378:metabolism; D051379:Mice; D009000:Monocytes / Q000378:metabolism; D018482:Muscle, Skeletal / Q000098:blood supply* / Q000378:metabolism / Q000503:physiopathology; D018919:Neovascularization, Physiologic; D019707:Receptors, Chemokine / Q000378:metabolism*; D012038:Regeneration; D015398:Signal Transduction
C491768:Ccl2 protein, mouse; D018932:Chemokine CCL2; D018925:Chemokines; D020523:Chemokines, CX3C; D019707:Receptors, Chemokine