title: Adjunctive fast repetitive transcranial magnetic stimulation in depression.
abstract: The place of repetitive transcranial magnetic stimulation (rTMS) in the treatment of depression remains unclear. In this sham-controlled study we determined the efficacy and acceptability offast, left frontal rTMS given three times a week over 4-6 weeks to 29 patients with depression (79% treatment-resistant). The procedure was generally well tolerated and more effective than sham treatment (55 v.77% responding, P<0.05), with improvement maintained to 12 weeks. This therapy could be a useful addition to available treatments but further research is needed to determine the optimum treatment parameters.
authors.affiliation: Neuroscience and Psychiatry Unit, University of Manchester, Manchester, UK. ian.anderson@manchester.ac.uk
authors.forename: Ian M
authors.initials: IM
authors.lastname: Anderson
authors.forename: Nicola A
authors.initials: NA
authors.lastname: Delvai
authors.forename: Bettadapura
authors.initials: B
authors.lastname: Ashim
authors.forename: Sindhu
authors.initials: S
authors.lastname: Ashim
authors.forename: Cherry
authors.initials: C
authors.lastname: Lewin
authors.forename: Vineet
authors.initials: V
authors.lastname: Singh
authors.forename: Daniel
authors.initials: D
authors.lastname: Sturman
authors.forename: Paul L
authors.initials: PL
authors.lastname: Strickland
mesh_terms: D000328:Adult; D003866:Depressive Disorder / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D050781:Transcranial Magnetic Stimulation / Q000379:methods*; D016896:Treatment Outcome