title: Effects of genetic polymorphisms of UCP2 and UCP3 on very low calorie diet-induced body fat reduction in Korean female subjects.
abstract: The uncoupling protein (UCP) family has been suggested as a possible determinant affecting obesity risk given their function in the regulation of energy metabolism. In an effort to elucidate the effects of UCP family polymorphisms on obesity phenotypes, we genotyped 10 polymorphisms in UCP2 and UCP3 among overweight female subjects (n=458), and genetic effects on BMI and changes after a very low calorie diet (VLCD) were examined. Analyses of VLCD-induced changes among the subjects who had finished one month-weight control program (n=301) revealed that several polymorphisms in UCP2-3 gene cluster showed associations with changes of BMI and fat mass, however not of protein mass. One of the major haplotypes of UCP2-3 gene cluster, ht1 (GGCdelCGTACC), and UCP2-866G>A showed significant associations with VLCD-induced fat reduction (P=0.002 and 0.004; P(corr)=0.03 and 0.01, respectively), and these results suggested that UCP2-3 polymorphisms were important genetic factor for the VLCD-induced reduction of body fat mass.
authors.affiliation: Department of Microbiology, Medical School, Chung-Ang University, Seoul 156-756, Republic of Korea.
authors.forename: Yoosik
authors.initials: Y
authors.lastname: Yoon
authors.forename: Byung Lae
authors.initials: BL
authors.lastname: Park
authors.forename: Min Ho
authors.initials: MH
authors.lastname: Cha
authors.forename: Kil Soo
authors.initials: KS
authors.lastname: Kim
authors.forename: Hyun Sub
authors.initials: HS
authors.lastname: Cheong
authors.forename: Yoo Hyun
authors.initials: YH
authors.lastname: Choi
authors.forename: Hyoung Doo
authors.initials: HD
authors.lastname: Shin
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism* / Q000473:pathology; D000328:Adult; D015992:Body Mass Index; D031204:Caloric Restriction; D005091:Exons / Q000235:genetics; D005260:Female; D006801:Humans; D007473:Ion Channels / Q000235:genetics*; D007723:Korea / Q000453:epidemiology; D024101:Mitochondrial Proteins / Q000235:genetics*; D009765:Obesity / Q000178:diet therapy* / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology; D010641:Phenotype; D011110:Polymorphism, Genetic / Q000235:genetics*; D000071246:Uncoupling Protein 2; D000071247:Uncoupling Protein 3
chemical_list: D007473:Ion Channels; D024101:Mitochondrial Proteins; C000604389:UCP2 protein, human; C000604392:UCP3 protein, human; D000071246:Uncoupling Protein 2; D000071247:Uncoupling Protein 3