Indole alkaloids produced by a marine fungus isolate of Penicillium janthinellum Biourge.
Three new indole alkaloids, shearinines D, E, and F (1-3), together with the known shearinine A (4) were isolated from the marine-derived strain of the fungus Penicillium janthinellum Biourge. The chemical structures of 1-4 were established by 2D NMR and HREIMS data. Shearinines A, D, and E induce apoptosis in human leukemia HL-60 cells, and shearinine E also inhibits EGF-induced malignant transformation of JB6 P+ Cl 41 cells in a soft agar.
Smetanina
Olga F
OF
Pacific Institute of Bioorganic Chemistry, Far East Branch of the Russian Academy of Sciences, Vladivostok 22, Russian Federation.
Kalinovsky
Anatoly I
AI
Khudyakova
Yuliya V
YV
Pivkin
Mikhail V
MV
Dmitrenok
Pavel S
PS
Fedorov
Sergey N
SN
Ji
Hong
H
Kwak
Jong-Young
JY
Kuznetsova
Tatyana A
TA
D016588:Anticarcinogenic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008386:Marine Biology; D015394:Molecular Structure; D010407:Penicillium / Q000737:chemistry*
D016588:Anticarcinogenic Agents; D000970:Antineoplastic Agents; D026121:Indole Alkaloids; C521532:shearinine D; C521534:shearinine E; C521533:shearinine F