A new cadinane sesquiterpene with significant anti-HIV-1 activity from the cultures of the basidiomycete Tyromyces chioneus.
A new cadinane sesquiterpene (4beta,14-dihydroxy-6alpha,7betaH-1(10)-cadinene, 1) was isolated from the cultures of the basidiomycete, Tyromyces chioneus. Its structure was established on the basis of spectral measurements (MS, IR, 1D and 2D NMR experiments). 1 showed significant anti-HIV-1 activity with EC50=3.0 microg/ml (SI=25.4).
Liu
Dong-Ze
DZ
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, China.
Wang
Fei
F
Yang
Liu-Meng
LM
Zheng
Yong-Tang
YT
Liu
Ji-Kai
JK
D019380:Anti-HIV Agents / Q000302:isolation & purification / Q000494:pharmacology*; D001487:Basidiomycota / Q000737:chemistry*; D045744:Cell Line, Tumor; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002855:Chromatography, Thin Layer; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D005285:Fermentation; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D009904:Optical Rotation; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes / Q000302:isolation & purification / Q000494:pharmacology*; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D013329:Structure-Activity Relationship
C522440:4,14-dihydroxy-6,7H-1(10)-cadinene; D019380:Anti-HIV Agents; D007202:Indicators and Reagents; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes