title: Studies on the lipophilicity of vehicles (or co-vehicles) and botanical oils used in cosmetic products.
abstract: The lipophilic character of five vehicles (or co-vehicles): diethylhexylmaleate, dimethicone, light mineral oil, octyldodecanol and oleyl alcohol and eight botanical oils: Aloe vera oil, coconut oil, extra virgin olive oil, grape leaf oil, grape seed oil, hazelnut oil, jojoba oil and safflower oil was determined by partitioning esters of p-hydroxybenzoic acid (parabens) between them and phosphate buffer (pH 7.4). The results were compared to those obtained with 1-octanol. The most lipophilic effects were observed with octyldodecanol and oleyl alcohol for the vehicles (or co-vehicles), coconut oil, jojoba oil and safflower oil for botanical oils. Light mineral oil showed the least lipophilic effect. With butylparaben, it was observed that oleyl alcohol, octyldodecanol, coconut oil and jojoba oil were 0.94, 0.91, 0.74 and 0.68 times as lipophilic as 1-octanol respectively. The study indicates that octyldodecanol and oleyl alcohol could be good substitutes for 1-octanol in partition coefficient determination. The estimated permeability coefficients of the parabens suggest that octyldodecanol, oleyl alcohol, coconut oil and jojoba oil could be potential dermal permeation enhancers.
authors.affiliation: DMI Inc., Wharton, NJ, USA.
authors.forename: C J
authors.initials: CJ
authors.lastname: Mbah
mesh_terms: D002021:Buffers; D002138:Calibration; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003358:Cosmetics / Q000737:chemistry*; D008055:Lipids / Q000737:chemistry*; D010226:Parabens / Q000737:chemistry; D010539:Permeability; D014677:Pharmaceutical Vehicles / Q000737:chemistry*; D010710:Phosphates / Q000737:chemistry; D010938:Plant Oils / Q000737:chemistry*; D012015:Reference Standards; D012044:Regression Analysis
chemical_list: D002021:Buffers; D003358:Cosmetics; D008055:Lipids; D010226:Parabens; D014677:Pharmaceutical Vehicles; D010710:Phosphates; D010938:Plant Oils