title: [The role of homocysteine thiolactone in some of human diseases].
abstract: In the present article we discuss the most recent data regarding the role of homocysteine, its cyclic thioester--homocysteine thiolactone and the process of protein N-homocysteinylation in human disease. The protective role of thiolactonase/paraoxonase enzyme, carried on high density lipoproteins (HDL) in human blood, as well as the influence of structural modifications on HDL function are discussed. We also describe the effect of vitamin therapy (folic acid, vitamins: B6, B12) used for lowering the homocysteine level in humans as well.
authors.affiliation: Instytut Chemii Bioorganicznej PAN, Poznań. martas@ibch.poznan.pl
authors.forename: Marta
authors.initials: M
authors.lastname: Sikora
authors.forename: Tomasz
authors.initials: T
authors.lastname: Twardowski
authors.forename: Hieronim
authors.initials: H
authors.lastname: Jakubowski
mesh_terms: D000818:Animals; D043303:Aryldialkylphosphatase / Q000097:blood*; D050197:Atherosclerosis / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D005340:Fibrinogen / Q000378:metabolism; D005492:Folic Acid / Q000097:blood / Q000627:therapeutic use; D006710:Homocysteine / Q000031:analogs & derivatives* / Q000097:blood / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood / Q000737:chemistry; D011817:Rabbits; D020521:Stroke / Q000097:blood*; D014805:Vitamin B 12 / Q000097:blood / Q000627:therapeutic use; D025101:Vitamin B 6 / Q000097:blood / Q000627:therapeutic use
chemical_list: D015415:Biomarkers; D008075:Lipoproteins, HDL; D006710:Homocysteine; D025101:Vitamin B 6; D005340:Fibrinogen; D005492:Folic Acid; C007957:homocysteine thiolactone; D043303:Aryldialkylphosphatase; D014805:Vitamin B 12