title: Radiologic findings in taxane induced colitis.
abstract: Ischemic colitis in breast cancer patients being treated with taxane-based chemotherapy, which may lead to serious morbidities and even death, has recently been defined as a clinical entity. The purpose of this retrospective study was to evaluate the computed tomography (CT) findings in taxane-related colitis and determine their clinical relevance. CT scans of 41 patients at risk for taxane colitis were reviewed retrospectively for bowel and peritoneal abnormalities. Morphological findings were analyzed and correlated with clinical, pathological, and endoscopic findings. CT scans in 10 of the 41 patients showed a definitely abnormal colon with a thickened wall or distended with fluid, signs that are suggestive of colitis, in the context of the clinical picture. Radiographic changes in patients with taxane colitis are not specific but, in the appropriate context, can suggest the correct diagnosis and guide the patient's management.
authors.affiliation: Department of Diagnostic Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. hkaur@di.mdacc.tmc.edu
authors.forename: Harmeet
authors.initials: H
authors.lastname: Kaur
authors.forename: Evelyne M
authors.initials: EM
authors.lastname: Loyer
authors.forename: Cynthia L
authors.initials: CL
authors.lastname: David
authors.forename: Hassan
authors.initials: H
authors.lastname: Sawaf
authors.forename: Ronelle A
authors.initials: RA
authors.lastname: DuBrow
authors.forename: Nuhad K
authors.initials: NK
authors.lastname: Ibrahim
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000188:drug therapy*; D003092:Colitis / Q000139:chemically induced* / Q000000981:diagnostic imaging*; D003287:Contrast Media; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D008875:Middle Aged; D012189:Retrospective Studies; D043823:Taxoids / Q000009:adverse effects*; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D003287:Contrast Media; D043823:Taxoids; C064925:gadodiamide; D019786:Gadolinium DTPA