Synthesis of C-11 modified mifepristone analog libraries.
Substitution of the C-11 aniline of mifepristone can provide compounds with altered pharmacokinetic and pharmacodynamic (PK/PD) profiles that may find use for new indications. The development of new steroid intermediates and specialized library synthesis methods were required to enable the efficient preparation of structurally complex C-11 modified mifepristone analogs.
Hamilton
Gregory L
GL
Metabolic Disease Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064-6098, USA.
Backes
Bradley J
BJ
D000814:Aniline Compounds / Q000737:chemistry; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D006727:Hormone Antagonists / Q000138:chemical synthesis; D015735:Mifepristone / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D008954:Models, Biological; D019151:Peptide Library
D000814:Aniline Compounds; D006727:Hormone Antagonists; D019151:Peptide Library; D015735:Mifepristone; C023650:aniline