title: Cytologic features of metanephric adenoma of the kidney during pregnancy: a case report.
abstract: BACKGROUND
  Metanephric adenoma (MA) is a relatively rare neoplasm derived from metanephric blastema and composed of well-differentiated epithelial nephroblastic cells. In view of its invariably benign clinical outcome, a preoperative diagnosis of this tumor could be of critical importance. Since computed tomography and ultrasound imaging are not per se sufficient to unequivocally distinguish between MA and malignant neoplasms, fine needle aspiration cytology (FNAC) could be the only accurate method to establish a preoperative diagnosis of this tumor. However, cytologic appearance of MA is not well characterized.
  
  
  METHODS
  A 33-year-old pregnant woman presented with erythrocytosis. Transabdominal ultrasound examination disclosed a mass in her left kidney. FNA smears showed small, uniform cells with bland nuclei arranged in compact acinar and follicular structures; immunocytochemical staining revealed a diffuse, positive reaction for CD57, WT-1 and vimentin, and epithelial membrane antigen and alpha-methylacyl-CoA racemase yielded negative results. These cytologic and immunocytochemicalfindings led to a preoperative diagnosis of MA. After delivery, the diagnosis was confirmed on the surgical specimen.
  
  
  CONCLUSIONS
  A diagnosis of MA could be established by FNAC supported by immunocytochemical analysis. The present case illustrates the clinical impact that this diagnosis could have on patient management.
authors.affiliation: Department of Biomedical Sciences and Human Oncology, University of Turin, Italy.
authors.forename: Martino
authors.initials: M
authors.lastname: Bosco
authors.forename: Diego
authors.initials: D
authors.lastname: Galliano
authors.forename: Fedele
authors.initials: F
authors.lastname: La Saponara
authors.forename: Donatella
authors.initials: D
authors.lastname: Pacchioni
authors.forename: Gianni
authors.initials: G
authors.lastname: Bussolati
mesh_terms: D000236:Adenoma / Q000473:pathology* / Q000601:surgery; D000328:Adult; D044963:Biopsy, Fine-Needle; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology* / Q000601:surgery; D009392:Nephrectomy; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000473:pathology* / Q000601:surgery; D011300:Preoperative Care