title: The association of RANTES polymorphism with severe acute respiratory syndrome in Hong Kong and Beijing Chinese.
abstract: BACKGROUND
  Chemokines play important roles in inflammation and antiviral action. We examined whether polymorphisms of RANTES, IP-10 and Mig affect the susceptibility to and outcome of severe acute respiratory syndrome (SARS).
  
  
  METHODS
  We tested the polymorphisms of RANTES, IP-10 and Mig for their associations with SARS in 495 Hong Kong Chinese SARS patients and 578 controls. Then we tried to confirm the results in 356 Beijing Chinese SARS patients and 367 controls.
  
  
  RESULTS
  RANTES -28 G allele was associated with SARS susceptibility in Hong Kong Chinese (P < 0.0001, OR = 2.80, 95%CI:2.11-3.71). Individuals with RANTES -28 CG and GG genotypes had a 3.28-fold (95%CI:2.32-4.64) and 3.06-fold (95%CI:1.47-6.39) increased risk of developing SARS respectively (P < 0.0001). This -28 G allele conferred risk of death in a gene-dosage dependent manner (P = 0.014) with CG and GG individuals having a 2.12-fold (95% CI: 1.11-4.06) and 4.01-fold (95% CI: 1.30-12.4) increased risk. For the replication of RANTES data in Beijing Chinese, the -28 G allele was not associated with susceptibility to SARS. However, -28 CG (OR = 4.27, 95%CI:1.64-11.1) and GG (OR = 3.34, 95%CI:0.37-30.7) were associated with admission to intensive care units or death due to SARS (P = 0.011).
  
  
  CONCLUSIONS
  RANTES -28 G allele plays a role in the pathogenesis of SARS.
authors.affiliation: Department of Paediatrics and Adolescent Medicine, The Hong Kong Jockey Club Research Centre, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China. ivy_natsu@yahoo.com.hk <ivy_natsu@yahoo.com.hk>
authors.forename: Man Wai
authors.initials: MW
authors.lastname: Ng
authors.forename: Gangqiao
authors.initials: G
authors.lastname: Zhou
authors.forename: Wai Po
authors.initials: WP
authors.lastname: Chong
authors.forename: Loretta Wing Yan
authors.initials: LW
authors.lastname: Lee
authors.forename: Helen Ka Wai
authors.initials: HK
authors.lastname: Law
authors.forename: Hongxing
authors.initials: H
authors.lastname: Zhang
authors.forename: Wilfred Hing Sang
authors.initials: WH
authors.lastname: Wong
authors.forename: Susanna Fung Shan
authors.initials: SF
authors.lastname: Fok
authors.forename: Yun
authors.initials: Y
authors.lastname: Zhai
authors.forename: Raymond W H
authors.initials: RW
authors.lastname: Yung
authors.forename: Eudora Y
authors.initials: EY
authors.lastname: Chow
authors.forename: Ka Leung
authors.initials: KL
authors.lastname: Au
authors.forename: Eric Y T
authors.initials: EY
authors.lastname: Chan
authors.forename: Wilina
authors.initials: W
authors.lastname: Lim
authors.forename: J S  Malik
authors.initials: JS
authors.lastname: Peiris
authors.forename: Fuchu
authors.initials: F
authors.lastname: He
authors.forename: Yu Lung
authors.initials: YL
authors.lastname: Lau
mesh_terms: D000328:Adult; D017677:Age Distribution; D016022:Case-Control Studies; D018946:Chemokine CCL5 / Q000235:genetics*; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D016001:Confidence Intervals; D005260:Female; D005500:Follow-Up Studies; D015967:Gene Expression Regulation, Viral; D020022:Genetic Predisposition to Disease / Q000453:epidemiology*; D006723:Hong Kong / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D011336:Probability; D018570:Risk Assessment; D045473:Severe acute respiratory syndrome-related coronavirus / Q000235:genetics* / Q000302:isolation & purification; D045169:Severe Acute Respiratory Syndrome / Q000453:epidemiology* / Q000235:genetics*; D017678:Sex Distribution
chemical_list: D018946:Chemokine CCL5