title: Two new bisorbicillinoids isolated from a deep-sea fungus, Phialocephala sp. FL30r.
abstract: Two new bisorbicillinoids, named oxosorbiquinol (1) and dihydrooxosorbiquinol (2), were isolated from a deep-sea fungus, Phialocephala sp., and their structures established using spectroscopic methods. The absolute configurations of 1 and 2 were determined by their biosynthesis route and analysis of the CD spectrum. Their cytotoxic effects on P388, A-549, HL60, BEL7402 and K562 cell lines were examined by the MTT method.
authors.affiliation: Key Laboratory of Marine Drugs, Chinese Ministry of Education, PR China.
authors.forename: Dehai
authors.initials: D
authors.lastname: Li
authors.forename: Fengping
authors.initials: F
authors.lastname: Wang
authors.forename: Shengxin
authors.initials: S
authors.lastname: Cai
authors.forename: Xiang
authors.initials: X
authors.lastname: Zeng
authors.forename: Xiang
authors.initials: X
authors.lastname: Xiao
authors.forename: Qianqun
authors.initials: Q
authors.lastname: Gu
authors.forename: Weiming
authors.initials: W
authors.lastname: Zhu
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification / Q000494:pharmacology; D001203:Ascomycota / Q000737:chemistry*; D045744:Cell Line, Tumor; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002942:Circular Dichroism; D004224:Diterpenes / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D013055:Spectrophotometry, Infrared; D013778:Tetrazolium Salts; D013844:Thiazoles
chemical_list: D000903:Antibiotics, Antineoplastic; D004224:Diterpenes; D013778:Tetrazolium Salts; D013844:Thiazoles; C522438:dihydrooxosorbiquinol; C522437:oxosorbiquinol; C022616:thiazolyl blue