title: Systems biology: a switch for sex.
abstract: The yeast pheromone response pathway works in a graded fashion, such that more pheromone leads to more response, but a recent study has shown that small modifications convert it into a bistable switch, with implications for the evolution and engineering of reaction networks.
authors.affiliation: Physical Biosciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, M.S. 977-152, Berkeley, California 94720, USA. ssandrews@lbl.gov <ssandrews@lbl.gov>
authors.forename: Steven S
authors.initials: SS
authors.lastname: Andrews
authors.forename: Adam P
authors.initials: AP
authors.lastname: Arkin
mesh_terms: D025461:Feedback, Physiological; D015966:Gene Expression Regulation, Fungal; D008954:Models, Biological; D010675:Pheromones / Q000502:physiology*; D012098:Reproduction / Q000502:physiology; D012441:Saccharomyces cerevisiae / Q000187:drug effects / Q000378:metabolism* / Q000502:physiology; D015398:Signal Transduction; D049490:Systems Biology
chemical_list: D010675:Pheromones