title: Selective cardiac neuroadrenergic abnormalities in hypertensive patients with left ventricular hypertrophy.
abstract: BACKGROUND
  Increased sympathetic drive to the heart might contribute to the development and progression of myocardial damage in hypertensive patients (HTs). This study assessed the possible presence of abnormalities in myocardial uptake of (123)I-metaiodobenzylguanidine (MIBG), a marker of sympathetic activity, in HTs with left ventricular hypertrophy (LVH).
  
  
  METHODS
  Eleven HTs with LVH and 10 matched normotensive controls underwent clinical and laboratory examination, as well as LVH determination by echocardiography. The presence of myocardial ischemia was ruled out by exercise stress testing. Global and regional myocardial uptake of (123)I-MIBG was determined in both groups using planar and single proton emission tomography scintigraphy. In addition, thallium-201 (Tl-201) myocardial scintigraphy was performed in HTs. The heart/mediastinum (H/M) ratio on planar (123)I-MIBG images at different time points was compared between HTs and controls. Moreover, regional cardiac uptake of (123)I-MIBG was compared between groups and, within the HTs group, with regional Tl-201 uptake.
  
  
  RESULTS
  At all study times, the H/M ratio was lower in HTs than in controls (all p <0.05). A significant reduction in (123)I-MIBG uptake in the mid-inferolateral and mid-inferior segments was observed in HTs compared to controls. Also, a significant reduction in (123)I-MIBG uptake compared to Tl-210 uptake was observed in non-septal segments of HTs.
  
  
  CONCLUSIONS
  Cardiac abnormalities in global and regional uptake of (123)I-MIBG, as well as impaired (123)I-MIBG compared to Tl-201 uptake, are present in HTs with LVH. Given the effect of sympathetic nervous system on the heart, these abnormalities might play a role in hypertension-related cardiac damage.
authors.affiliation: Istituto di Medicina Nucleare, Università Cattolica, Roma, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Giordano
authors.forename: Giovanni
authors.initials: G
authors.lastname: Melina
authors.forename: Maria Lucia
authors.initials: ML
authors.lastname: Calcagni
authors.forename: Francesca
authors.initials: F
authors.lastname: Schinzari
authors.forename: Fiammetta
authors.initials: F
authors.lastname: Cirillo
authors.forename: Marco
authors.initials: M
authors.lastname: Mettimano
authors.forename: Carmine
authors.initials: C
authors.lastname: Cardillo
authors.forename: Domenico
authors.initials: D
authors.lastname: Melina
mesh_terms: D019797:3-Iodobenzylguanidine; D004452:Echocardiography; D005260:Female; D006321:Heart; D006801:Humans; D006973:Hypertension / Q000000981:diagnostic imaging* / Q000503:physiopathology; D017379:Hypertrophy, Left Ventricular / Q000097:blood / Q000000981:diagnostic imaging* / Q000503:physiopathology; D007457:Iodine Radioisotopes; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000000981:diagnostic imaging; D011877:Radionuclide Imaging; D013564:Sympathetic Nervous System / Q000000981:diagnostic imaging*; D013794:Thallium Radioisotopes
chemical_list: D007457:Iodine Radioisotopes; D013794:Thallium Radioisotopes; D019797:3-Iodobenzylguanidine