title: [Effectiveness of nasal vs oral estrogens in the climacteric syndrome].
abstract: BACKGROUND
  Hormone replacement therapy reestablishes the diminished hormonal level and reduces mild, moderate and severe effects of climacteric. Its treatment includes estrogens, progestagens and a mixture of both.
  
  
  OBJECTIVE
  To evaluate the efficacy of intranasal and oral estrogens in the climacteric syndrome.
  
  
  METHODS
  60 patients were evaluated with climacteric syndrome; 30 received intranasal estrogens (group A) and 30 received oral estrogens (group B). Age range, 34-64 years. The symptoms were classified as vasomotor, collagen related symptoms and tropic changes. The patients were evaluated four times a week, and the symptoms were measured as mild, moderate and severe according with the Guía de evaluación de riesgo en la paciente climatérica.
  
  
  RESULTS
  Group A (intranasal estrogens) showed faster clinical response in the first two weeks (63%), compared with group B (30%). No side effects were found in both groups.
  
  
  CONCLUSIONS
  Climacteric syndrome can be treated better and faster with intranasal estrogens than with oral estrogens, and without side effects.
authors.affiliation: Hospital Regional General Ignacio Zaragoza, ISSSTE, México, DF. galirolaa@hotmail.com
authors.forename: Gabriela Liliana
authors.initials: GL
authors.lastname: Romano Lagunas
authors.forename: Juan
authors.initials: J
authors.lastname: Miranda Murillo
authors.forename: Alfonso A
authors.initials: AA
authors.lastname: Vázquez López
authors.forename: Fausto
authors.initials: F
authors.lastname: Coronel Cruz
authors.forename: Patricio
authors.initials: P
authors.lastname: Guerra Ulloa
mesh_terms: D000281:Administration, Intranasal; D000284:Administration, Oral; D000328:Adult; D000336:Aerosols; D004967:Estrogens / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008593:Menopause / Q000187:drug effects* / Q000502:physiology*; D008875:Middle Aged
chemical_list: D000336:Aerosols; D004967:Estrogens