Effects of scaling and root planing and sub-antimicrobial dose doxycycline on oral and systemic biomarkers of disease in patients with both chronic periodontitis and coronary artery disease.
OBJECTIVE
This study evaluated the effects of scaling and root planing (SRP) +/- sub-antimicrobial dose doxycycline (SDD) on gingival crevicular fluid (GCF) levels of matrix metalloproteinase (MMP) -1, -8, -13 and on serum levels of high-sensitivity C-reactive protein (HsCRP) and lipid fractions in patients with both chronic periodontitis (CP) and coronary artery disease (CAD).


METHODS
Thirty-six patients were randomly distributed into two groups (Placebo or SDD; 6 weeks) and both received two regimens of SRP. At baseline and 6 weeks, GCF and blood were collected and clinical indices were recorded. MMPs, HsCRP and lipid fractions were assayed.


RESULTS
There were statistically significant improvements for all clinical parameters, GCF volumes, GCF MMPs and serum levels of HsCRP, apolipoprotein-A (APO-A), high-density lipoprotein (HDL) and lipoprotein-a between pre- and post-treatment in both groups. Between groups, there were statistically significant greater improvements in pocket depth (PD), gingival index (GI), APO-A and HDL, favouring the group receiving SDD adjunctive to SRP (p < 0.05).


CONCLUSIONS
Greater improvement was detected for PD and GI, and for serum levels of APO-A and HDL cholesterol when using SRP+SDD compared with SRP+placebo in this study. An investigation with larger numbers of patients and a longer duration of drug treatment is needed to confirm these preliminary findings.
Tüter
Gülay
G
Department of Periodontology, Faculty of Dentistry, Gazi University, Ankara, Turkiye. gulay@gazi.edu.tr
Kurtiş
Bülent
B
Serdar
Muhittin
M
Aykan
Tuba
T
Okyay
Kaan
K
Yücel
Ayşegül
A
Toyman
Utku
U
Pinar
Selin
S
Cemri
Mustafa
M
Cengel
Atiye
A
Walker
Stephen G
SG
Golub
Lorne M
LM
D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis / Q000187:drug effects; D002908:Chronic Disease; D003324:Coronary Artery Disease / Q000150:complications / Q000201:enzymology*; D012534:Dental Scaling; D004318:Doxycycline / Q000008:administration & dosage*; D004812:Epidemiologic Methods; D005260:Female; D005883:Gingival Crevicular Fluid / Q000201:enzymology; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D020781:Matrix Metalloproteinase 1 / Q000032:analysis / Q000187:drug effects*; D008875:Middle Aged; D010518:Periodontitis / Q000150:complications / Q000201:enzymology*; D016745:Root Planing
D000900:Anti-Bacterial Agents; D015415:Biomarkers; D008055:Lipids; D002097:C-Reactive Protein; D020781:Matrix Metalloproteinase 1; D004318:Doxycycline