title: Gastroesophageal reflux in patients with recurrent laryngeal papillomatosis.
abstract: Evidence of a relation between gastroesophaeal reflux and pediatric respiratory disorders increases every year. Many respiratory symptoms and clinical conditions such as stridor, chronic cough, and recurrent pneumonia and bronchitis appear to be related to gastroesophageal reflux. Some studies have also suggested that gastroesophageal reflux may be associated with recurrent laryngeal papillomatosis, contributing to its recurrence and severity.
  
  
  OBJECTIVE
  the aim of this study was to verify the frequency and intensity of gastroesophageal reflux in children with recurrent laryngeal papillomatosis.
  
  
  METHODS
  ten children of both genders, aged between 3 and 12 years, presenting laryngeal papillomatosis, were included in this study. The children underwent 24-hour double-probe pH-metry.
  
  
  RESULTS
  fifty percent of the patients had evidence of gastroesophageal reflux at the distal sphincter; 90% presented reflux at the proximal sphincter.
  
  
  CONCLUSIONS
  the frequency of proximal gastroesophageal reflux is significantly increased in patients with recurrent laryngeal papillomatosis.
authors.affiliation: Dept. Otorrinolaringologia e Cirurgia de Cabeça e Pescoço, Escola Paulista de Medicina, Universidade Federal de São Paulo. pigna@terra.com.br
authors.forename: Shirley Shizue Nagata
authors.initials: SS
authors.lastname: Pignatari
authors.forename: Raquel Ysabel Guzmán
authors.initials: RY
authors.lastname: Liriano
authors.forename: Melissa A G
authors.initials: MA
authors.lastname: Avelino
authors.forename: José Ricardo Gurgel
authors.initials: JR
authors.lastname: Testa
authors.forename: Reginaldo
authors.initials: R
authors.lastname: Fujita
authors.forename: Eduardo Kutchell
authors.initials: EK
authors.lastname: De Marco
mesh_terms: D002648:Child; D002675:Child, Preschool; D005260:Female; D005764:Gastroesophageal Reflux / Q000150:complications*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007822:Laryngeal Neoplasms / Q000150:complications*; D008297:Male; D008365:Manometry; D009364:Neoplasm Recurrence, Local; D010212:Papilloma / Q000150:complications*; D012720:Severity of Illness Index