title: Portal vein embolization before major hepatectomy and its effects on regeneration, resectability and outcome.
abstract: BACKGROUND
  This study evaluated the safety of portal vein embolization (PVE), its impact on future liver remnant (FLR) volume and regeneration, and subsequent effects on outcome after liver resection.
  
  
  METHODS
  Records of 112 patients were reviewed. Standardized FLR (sFLR) and degree of hypertrophy (DH; difference between the sFLR before and after PVE), complications and outcomes were analysed to determine cut-offs that predict postoperative hepatic dysfunction.
  
  
  RESULTS
  Ten (8.9 per cent) of 112 patients had PVE-related complications. Postoperative complications occurred in 34 (44 per cent) of 78 patients who underwent hepatic resection and the 90-day mortality rate was 3 per cent. A sFLR of 20 per cent or less after PVE or DH of not more than 5 per cent (versus sFLR greater than 20 per cent and DH above 5 per cent) had a sensitivity of 80 per cent and a specificity of 94 per cent in predicting hepatic dysfunction. Overall, major and liver-related complications, hepatic dysfunction or insufficiency, hospital stay and 90-day mortality rate were significantly greater in patients with a sFLR of 20 per cent or less or DH of not more than 5 per cent compared with patients with higher values.
  
  
  CONCLUSIONS
  DH contributes prognostic information additional to that gained by volumetric evaluation in patients undergoing PVE.
authors.affiliation: Department of Surgical Oncology, University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA.
authors.forename: D
authors.initials: D
authors.lastname: Ribero
authors.forename: E K
authors.initials: EK
authors.lastname: Abdalla
authors.forename: D C
authors.initials: DC
authors.lastname: Madoff
authors.forename: M
authors.initials: M
authors.lastname: Donadon
authors.forename: E M
authors.initials: EM
authors.lastname: Loyer
authors.forename: J-N
authors.initials: JN
authors.lastname: Vauthey
mesh_terms: D000328:Adult; D000368:Aged; D004621:Embolization, Therapeutic / Q000379:methods*; D005260:Female; D006498:Hepatectomy / Q000379:methods; D006529:Hepatomegaly / Q000209:etiology; D006801:Humans; D008113:Liver Neoplasms / Q000601:surgery*; D008115:Liver Regeneration / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D011169:Portal Vein; D011300:Preoperative Care; D016896:Treatment Outcome