title: Dengue virus regulates the expression of hemostasis-related molecules in human vein endothelial cells.
abstract: OBJECTIVE
  Hemorrhage is considered to be the primary sign of Dengue hemorrhagic fever and Dengue shock syndrome. In the present study we focused on the mechanism in the pro- and anti-coagulation after Dengue virus infection.
  
  
  METHODS
  The effects of Dengue virus on the expression and secretion of tissue factor, tissue factor inhibitor, thrombomodulin, tissue plasminogen activator and plasminogen activator inhibitor type-1 in human umbilical vein endothelial cells were detected in this study.
  
  
  RESULTS
  It was shown that Dengue virus could promote the expression of thrombomodulin in cultured human umbilical vein endothelial cells, thus increasing anticoagulation, and enhancing tissue plasminogen activator activity and therefore increased hemorrhage risk.
  
  
  CONCLUSIONS
  The changes above may play an important role in the development of Dengue hemorrhagic fever and Dengue shock syndrome.
authors.affiliation: Department of Microbiology and Immunology, Medical College, Jinan University, Huangpu Dadao 601, Guangzhou 510632, People's Republic of China.
authors.forename: Zhenyou
authors.initials: Z
authors.lastname: Jiang
authors.forename: Xiaolong
authors.initials: X
authors.lastname: Tang
authors.forename: Rui
authors.initials: R
authors.lastname: Xiao
authors.forename: Lifang
authors.initials: L
authors.lastname: Jiang
authors.forename: Xiaoyin
authors.initials: X
authors.lastname: Chen
mesh_terms: D003716:Dengue Virus / Q000235:genetics / Q000472:pathogenicity*; D004730:Endothelium, Vascular / Q000378:metabolism / Q000821:virology*; D006487:Hemostasis; D006801:Humans; D017395:Plasminogen Activator Inhibitor 1 / Q000096:biosynthesis / Q000097:blood*; D019595:Severe Dengue / Q000097:blood*; D018180:Thrombomodulin / Q000096:biosynthesis / Q000097:blood*; D010959:Tissue Plasminogen Activator / Q000096:biosynthesis / Q000097:blood*; D014471:Umbilical Veins
chemical_list: D017395:Plasminogen Activator Inhibitor 1; D018180:Thrombomodulin; D010959:Tissue Plasminogen Activator