[Relationship between HER-2/neu over-expression and androgen independent prostate cancer].
OBJECTIVE
To detect HER-2/neu expression in prostate cancer tissues of both androgen dependent and independent groups and to evaluate the role of HER-2/neu in androgen independent prostate cancer.


METHODS
Immunohistochemical assay was used in the detection of HER-2/neu in the prostate cancer samples from 30 cases of androgen dependent cancer and 24 cases of androgen independent cancer. The correlation was analyzed between HER-2/neu over-expression and the tumor's clinical stage and Gleason score.


RESULTS
The rates of HER-2/neu over-expression were 10% and 33% in the androgen dependent group and the androgen independent group, significantly higher in the Gleason score >7 group and the clinical stage > T2 group than in the -7 group and the > T2 group (14.29% vs. 26.92%, 34.62% vs. 7.14%, P < 0.01).


CONCLUSIONS
The rate of HER-2/neu over-expression is high in androgen independent prostate cancer and is correlated with the tumor stage and Gleason score.
Bai
Qiang
Q
Department of Urology, Xinhua Hospital Affiliated to Shanghai Jiaotong University, Shanghai 200092, China. qiangbai@eyou.com
Chen
Fang
F
Qi
Juan
J
Chen
Jian-hua
JH
Wang
Yi-xin
YX
D000728:Androgens / Q000502:physiology*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D009367:Neoplasm Staging; D009376:Neoplasms, Hormone-Dependent / Q000378:metabolism* / Q000473:pathology; D011471:Prostatic Neoplasms / Q000378:metabolism* / Q000473:pathology; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000096:biosynthesis*
D000728:Androgens; D018719:Erb-b2 Receptor Tyrosine Kinases