Influence of silicon concentration on the haemocompatibility of amorphous carbon.
Amorphous carbon (a-C) has good blood compatibility and has been proposed as a coating material for blood contacting devices such as heart pumps and stents. In this study, unhydrogenated a-C films with different silicon concentrations were synthesized by magnetron sputtering, and the corresponding evolution of the surface energy and compatibility with blood were analysed. The incorporation of silicon not only decreased the sp(2)-hybridized carbon bonding configurations, but the static evaluation of the films incubated in human platelet-rich plasma also showed a decrease in platelet adhesion. Bonding structure and surface energy were determined to be factors contributing to the improved haemocompatibility.
Ong
Soon-Eng
SE
School of Mechanical and Aerospace Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Singapore.
Zhang
Sam
S
Du
Hejun
H
Too
Hui-Chin
HC
Aung
Kyaw-Naing
KN
D001769:Blood / Q000378:metabolism*; D001792:Blood Platelets / Q000378:metabolism; D002244:Carbon / Q000737:chemistry* / Q000378:metabolism; D020099:Coated Materials, Biocompatible / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D008422:Materials Testing; D010100:Oxygen / Q000378:metabolism; D010973:Platelet Adhesiveness; D012825:Silicon / Q000737:chemistry* / Q000378:metabolism; D013499:Surface Properties
D020099:Coated Materials, Biocompatible; D002244:Carbon; D010100:Oxygen; D012825:Silicon