Carbohydrate-based macrolides prepared via a convergent ring closing metathesis approach: in search for novel antibiotics.
An efficient convergent approach has been developed for the construction of novel, nonnatural polysubstituted carbohydrate-based macrolides. A key step in the synthesis is the formation of the macrocyclic ring via a ring-closing metathesis reaction. The obtained macrolide analogues have been screened for biological activity against gram-positive and gram-negative bacteria, yeasts, and molds.
Ruttens
Bart
B
Laboratory for Organic and Bioorganic Synthesis, Department of Organic Chemistry, Ghent University, Krijgslaan 281 (S4), B-9000 Gent, Belgium.
Blom
Petra
P
Van Hoof
Steven
S
Hubrecht
Idzi
I
Van der Eycken
Johan
J
Sas
Benedikt
B
Van Hemel
Johan
J
Vandenkerckhove
Jan
J
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry; D002241:Carbohydrates / Q000737:chemistry*; D003500:Cyclization; D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D021241:Spectrometry, Mass, Electrospray Ionization
D000900:Anti-Bacterial Agents; D002241:Carbohydrates; D018942:Macrolides