Synthesis, characterization and hydrolytic degradation study of polyetheresteramide copolymers based on epsilon-caprolactone, 6-aminocaproic acid, and poly(ethylene glycol).
In this paper, a new kind of biodegradable aliphatic polyetheresteramide copolymers (PEEA) based on epsilon-caprolactone, 6-aminocaproic acid, and poly(ethylene glycol) (PEG) were synthesized by melt polymerization method. The obtained copolymers were characterized by 1H-NMR. The thermal properties of PEEA copolymers were studied by DSC and TGA/DTA under nitrogen atmosphere. The water absorption and hydrolytic degradation behavior was also studied in detail. With the increase in PEG content or the decrease in caprolactone content, the water absorption of the copolymers increased accordingly. For the hydrolytic degradation behavior, with the increase in PEG content or caprolactone content, the degradation rate increased then.
Liu
CaiBing
C
State Key Laborotary of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China.
Qian
ZhiYong
Z
Jia
WenJuan
W
Huang
MeiJuan
M
Chao
GuoTao
G
Gong
ChangYang
C
Deng
HongXin
H
Wen
YanJun
Y
Yang
JinLiang
J
Gou
MaLing
M
Tu
MingJing
M
D000042:Absorption; D015119:Aminocaproic Acid / Q000737:chemistry*; D002208:Caproates / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D007783:Lactones / Q000737:chemistry*; D008422:Materials Testing; D008954:Models, Biological; D011092:Polyethylene Glycols / Q000737:chemistry*; D011108:Polymers / Q000138:chemical synthesis* / Q000378:metabolism*; D014867:Water / Q000378:metabolism
D002208:Caproates; D007783:Lactones; D011108:Polymers; D014867:Water; D011092:Polyethylene Glycols; C121056:caprolactone; D015119:Aminocaproic Acid