title: Thyroid gangliosides with high affinity for thyrotropin: potential role in thyroid regulation.
abstract: Thyroid cell membranes contain a multiplicity of gangliosides, some of which inhibit thyrotropin binding to thyroid membranes. The most potent inhibitor is a ganglioside which is present in only trace amounts and appears to have a novel structure. Thyroid gangliosides may play a role in relaying the hormonal message to the thyroid cell.
authors.affiliation: Laboratory of Biochemical Pharmacology, National Institute of Arthritis, Metabolism, and Digestive Diseases, Bethesda, MD 20014, USA.
authors.forename: B R
authors.initials: BR
authors.lastname: Mullin
authors.forename: T
authors.initials: T
authors.lastname: Pacuszka
authors.forename: G
authors.initials: G
authors.lastname: Lee
authors.forename: L D
authors.initials: LD
authors.lastname: Kohn
authors.forename: R O
authors.initials: RO
authors.lastname: Brady
authors.forename: P H
authors.initials: PH
authors.lastname: Fishman
mesh_terms: D000818:Animals; D002417:Cattle; D002462:Cell Membrane / Q000378:metabolism; D005732:Gangliosides / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D012794:Sialic Acids / Q000032:analysis; D013961:Thyroid Gland / Q000378:metabolism*; D013972:Thyrotropin / Q000037:antagonists & inhibitors / Q000378:metabolism*
chemical_list: D005732:Gangliosides; D012794:Sialic Acids; D013972:Thyrotropin