title: Effects of vardenafil on intraocular pressure and orbital hemodynamics.
abstract: OBJECTIVE
  The aim of this study was to investigate the effects of vardenafil on systemic blood pressure, intraocular pressure (IOP), and orbital hemodynamics.
  
  
  METHODS
  Twenty-one (21) volunteers suffering erectile dysfunction, with an average age of 51.5 +/- 6.2 years, were enrolled into the study. Brachial blood pressures and IOP were measured, the peak systolic velocity (PSV), end-diastolic velocity (EDV), and resistive index (RI) of the ophthalmic, central retinal, and posterior ciliary arteries were evaluated by color Doppler ultrasonography (CDU) before vardenafil intake. All measurements were repeated after 20 min of vardenafil intake. A paired Student t test was used to evaluate the changes.
  
  
  RESULTS
  Systolic blood pressure did not change significantly where diastolic blood pressure decreased significantly (P = 0.043) after drug ingestion. There was no significant change in IOP. Increase in EDV of CRA was significant (P = 0.04), but the increase of orbital blood flow velocities of OA and PCA were insignificant.
  
  
  CONCLUSIONS
  The recommended dose of vardenafil has no negative effects on orbital hemodynamics and IOP in patients with erectile dysfunction.
authors.affiliation: Department of Opthalmology, University of Kirikkale, School of Medicine, Kirikkale, Turkey.
authors.forename: Pelin
authors.initials: P
authors.lastname: Taner
authors.forename: M Murad
authors.initials: MM
authors.lastname: Başar
authors.forename: Birsen
authors.initials: B
authors.lastname: Unal
authors.forename: Ertan
authors.initials: E
authors.lastname: Batislam
mesh_terms: D001783:Blood Flow Velocity / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D019842:Ciliary Arteries / Q000187:drug effects; D007172:Erectile Dysfunction / Q000188:drug therapy*; D006801:Humans; D007093:Imidazoles / Q000009:adverse effects / Q000494:pharmacology*; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D009880:Ophthalmic Artery / Q000187:drug effects; D010726:Phosphodiesterase Inhibitors / Q000009:adverse effects / Q000494:pharmacology*; D010879:Piperazines / Q000009:adverse effects / Q000494:pharmacology*; D012161:Retinal Artery / Q000187:drug effects; D013450:Sulfones / Q000009:adverse effects / Q000494:pharmacology; D014227:Triazines / Q000009:adverse effects / Q000494:pharmacology; D018615:Ultrasonography, Doppler, Color; D000069058:Vardenafil Dihydrochloride; D014665:Vasodilator Agents / Q000009:adverse effects / Q000494:pharmacology*; D014792:Visual Acuity / Q000187:drug effects
chemical_list: D007093:Imidazoles; D010726:Phosphodiesterase Inhibitors; D010879:Piperazines; D013450:Sulfones; D014227:Triazines; D014665:Vasodilator Agents; D000069058:Vardenafil Dihydrochloride