title: The genome of Salmonella enterica serovar Typhi.
abstract: The generation of complete genome sequences provides a blueprint that facilitates the genetic characterization of pathogens and their hosts. The genome of Salmonella enterica serovar Typhi (S. Typhi) harbors ~5 million base pairs encoding some 4000 genes, of which >200 are functionally inactive. Comparison of S. Typhi isolates from around the world indicates that they are highly related (clonal) and that they emerged from a single point of origin ~30,000-50,000 years ago. Evidence suggests that, as well as undergoing gene degradation, S. Typhi has also recently acquired genes, such as those encoding the Vi antigen, by horizontal transfer events.
authors.affiliation: The Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom.
authors.forename: Stephen
authors.initials: S
authors.lastname: Baker
authors.forename: Gordon
authors.initials: G
authors.lastname: Dougan
mesh_terms: D000942:Antigens, Bacterial / Q000235:genetics*; D004926:Escherichia coli / Q000235:genetics; D016680:Genome, Bacterial; D006790:Host-Parasite Interactions; D006801:Humans; D011135:Polysaccharides, Bacterial / Q000235:genetics*; D012485:Salmonella typhi / Q000145:classification / Q000235:genetics* / Q000472:pathogenicity; D012486:Salmonella typhimurium / Q000235:genetics; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA; D014774:Virulence / Q000235:genetics
chemical_list: D000942:Antigens, Bacterial; D011135:Polysaccharides, Bacterial