[Toll-like receptors, a new way of treatment?].
Toll-like receptors (TLRs) comprise a group of recently discovered receptors which are essential molecular structures in the activation of immunity. The discovery of TLRs has provided a substantial increase in the knowledge of immunologic aspects of disease pathology and is presently giving rise to new treatment strategies. This review summarizes the current knowledge on TLRs functioning in infections, their possible roles in inflammatory bowl disease and the pivotal role for TLRs in endotoxic shock, an area which is currently subject to development of a new farmakon.
Pedersen
Claus Vinter Bødker
CV
Arhus Universitetshospital, Infektionsmedicinsk Afdeling Q, Skejby, Arhus N. claus_vinter@hotmail.com
Østergaard
Lars J
LJ
Mogensen
Trine H
TH
Paludan
Søren Riis
SR
Bertelsen
Lone Skovbo
LS
D000818:Animals; D001424:Bacterial Infections / Q000188:drug therapy / Q000209:etiology / Q000276:immunology; D004187:Disaccharides / Q000627:therapeutic use; D006801:Humans; D007113:Immunity, Innate; D015212:Inflammatory Bowel Diseases / Q000188:drug therapy / Q000209:etiology / Q000276:immunology; D012772:Shock, Septic / Q000188:drug therapy / Q000209:etiology / Q000276:immunology; D013403:Sugar Phosphates / Q000627:therapeutic use; D051193:Toll-Like Receptors / Q000187:drug effects / Q000276:immunology / Q000502:physiology; D014777:Virus Diseases / Q000188:drug therapy / Q000209:etiology / Q000276:immunology
D004187:Disaccharides; D013403:Sugar Phosphates; D051193:Toll-Like Receptors; C512420:eritoran