In vitro substance P-dependent induction of bone marrow cells in common (CD10) acute lymphoblastic leukaemia.
The aim of the present research was to investigate the possible in vitro stimulatory effect of substance P (SP) on blasts induction in childhood common acute lymphoblastic leukaemia (ALL). Bone marrow aspirates were incubated with SP receptor agonist or antagonist (spantide) and subsequently assayed for the presence of human interleukin (IL)-1b using ELISA kit. Blast cells incubated with SP receptor agonist were found to result in a significant increase of IL-1b concentration while incubated with spantide resulted in control levels of IL-1b. These findings suggest the novel possible role of SP in blasts proliferation in childhood ALL of common (CD10) origin.
Nowicki
M
M
Department of Histology and Embryology, University of Medical Sciences in Poznan, Swiecickiego 6, 60-781 Poznan, Poland. mnowiki@amp.edu.pl
Ostalska-Nowicka
D
D
Miskowiak
B
B
D000293:Adolescent; D001854:Bone Marrow Cells; D049109:Cell Proliferation; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D053583:Interleukin-1beta / Q000378:metabolism; D008297:Male; D064729:Neurokinin-1 Receptor Antagonists; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma; D013373:Substance P / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000502:physiology*
D053583:Interleukin-1beta; D064729:Neurokinin-1 Receptor Antagonists; D013373:Substance P; C042867:spantide