The role of the Pro12Ala polymorphism in peroxisome proliferator-activated receptor gamma in diabetes risk.
OBJECTIVE
To provide a timely update of the literature regarding the role of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor gamma gene in type 2 diabetes and related phenotypes.


RESULTS
The adipocyte-specific gamma2 isoform of peroxisome proliferator-activated receptor gamma is now considered to be one of the best-replicated genetic risk factors of common type 2 diabetes. The effect is relatively weak (pooled odds ratio is about 1.2) but because of the high prevalence and population-attributable risk, this polymorphism becomes relevant for assessing genetic susceptibility for type 2 diabetes. Less clear is the association with prediabetes subphenotypes where effects were only detectable in selected subgroups. Furthermore this review gives an overview about possible mechanisms of peroxisome proliferator-activated receptor gamma effects, gene-environment interactions, relevance to the therapeutic response to thiazolidinediones and further clinical observations.


CONCLUSIONS
In conclusion, the Pro12 allele of peroxisome proliferator-activated receptor gamma is a robust diabetes-risk allele, as confirmed by many replications. There are many more clinical observations related to the Pro12Ala genotype which could be interesting and these clearly need to be analyzed in future studies.
Tönjes
Anke
A
Department of Medicine, University of Leipzig, Leipzig, Germany.
Stumvoll
Michael
M
D000409:Alanine / Q000235:genetics; D000483:Alleles; D019943:Amino Acid Substitution; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D004777:Environment; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D047495:PPAR gamma / Q000235:genetics*; D011110:Polymorphism, Genetic; D011392:Proline / Q000235:genetics; D012307:Risk Factors
D047495:PPAR gamma; D011392:Proline; D000409:Alanine