Modulation of spiral wave reentry by K(+) channel blockade.
It is well established that spiral wave reentry is the primary mechanism of ventricular tachyarrhythmias (ventricular fibrillation/tachycardia, VF/VT), but information is still limited concerning pharmacological modification of spiral waves by ion channel blockers. In this brief review, the antiarrhythmic and proarrhythmic actions of K(+)-channel blockade (I(Kr) and I (K1)) are discussed in terms of spiral wave dynamics, primarily based on recent experimental findings in ventricular preparations perfused in vitro with the aid of high-resolution optical mapping, as well as their related theoretical studies using computer simulation.
Honjo
Haruo
H
Department of Cardiovascular Research, Research Institute of Environmental Medicine, Nagoya University, Chikusa-ku, Nagoya 464-8601, Japan. honjo@riem.nagoya-u.ac.jp
Yamazaki
Masatoshi
M
Kamiya
Kaichiro
K
Kodama
Itsuo
I
D000200:Action Potentials; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D003198:Computer Simulation; D022062:Electrophysiologic Techniques, Cardiac; D006329:Heart Conduction System / Q000187:drug effects* / Q000378:metabolism / Q000503:physiopathology; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D008955:Models, Cardiovascular; D026902:Potassium Channel Blockers / Q000009:adverse effects / Q000627:therapeutic use*; D015221:Potassium Channels / Q000187:drug effects* / Q000378:metabolism; D016896:Treatment Outcome
D000889:Anti-Arrhythmia Agents; D026902:Potassium Channel Blockers; D015221:Potassium Channels