title: Vitamin C status in Iranian children with acute lymphoblastic leukemia: evidence for increased utilization.
abstract: Vitamin C status and total antioxidant capacity (TAC) in children with acute lymphoblastic leukemia (ALL) was assessed in 28 hospitalized patients and 30 apparently healthy control subjects. It was determined that whereas vitamin C intake in patients with ALL was more than twice as much as in controls, plasma and urinary concentrations of vitamin C were more than 10 times and 2.5 times higher in controls than in the patients with ALL, respectively (P < 0.001). Accordingly, serum TAC levels in the patients with ALL were lower than in healthy subjects (P < 0.001). Vitamin C utilization is increased in children with ALL.
authors.affiliation: National Institute of Nutrition and Food Technology Researches, Shaheed Beheshti University of Medical Sciences, Tehran, Iran. tneyestani@nnftri.ac.ir
authors.forename: Tirang R
authors.initials: TR
authors.lastname: Neyestani
authors.forename: Zahra
authors.initials: Z
authors.lastname: Fereydouni
authors.forename: Sima
authors.initials: S
authors.lastname: Hejazi
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Salehi-Nasab
authors.forename: Fariba
authors.initials: F
authors.lastname: Nateghifard
authors.forename: Mohsen
authors.initials: M
authors.lastname: Maddah
authors.forename: Majid
authors.initials: M
authors.lastname: Karandish
mesh_terms: D000293:Adolescent; D000975:Antioxidants / Q000008:administration & dosage / Q000378:metabolism*; D001205:Ascorbic Acid / Q000008:administration & dosage / Q000378:metabolism*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D004032:Diet; D005260:Female; D006801:Humans; D007492:Iran; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000378:metabolism*
chemical_list: D000975:Antioxidants; D001205:Ascorbic Acid