Human neural progenitor cell transplants into the subthalamic nucleus lead to functional recovery in a rat model of Parkinson's disease.
Despite the success of foetal nigral transplantation for the treatment of Parkinson's disease, supply limitations of tissue means that alternative sources must be found. Transplantation of human neural progenitor cells (HNPCs) may offer a solution, however few studies have shown functional recovery in animal models of PD without cell modification. Here we show that unmodified HNPC grafted into the subthalamic nucleus (STN) show excellent survival of up to 5 months and induce significant functional recovery following amphetamine-induced rotations within 4 weeks. For the first time we also show that HNPCs, which remain in an immature nestin-positive state, produce VEGF in vivo allowing further modification of the host brain. This suggests that even in the absence of cell replacement strategies utilising immature progenitor cells could be of real therapeutic value.
Anderson
Lucy
L
Centre for Brain Repair and Department of Clinical Neurosciences, University Forvie Site, Robinson Way, Cambridge, CB2 2PY, UK.
Caldwell
Maeve A
MA
D000818:Animals; D016380:Brain Tissue Transplantation; D004195:Disease Models, Animal; D005260:Female; D016332:Fetal Tissue Transplantation; D006085:Graft Survival; D006801:Humans; D007150:Immunohistochemistry; D009474:Neurons / Q000637:transplantation*; D020734:Parkinsonian Disorders / Q000601:surgery*; D051381:Rats; D020127:Recovery of Function; D033581:Stem Cell Transplantation; D020531:Subthalamic Nucleus / Q000601:surgery*