Dual action-based approaches to antibacterial agents.
This review collates and analyses recent work done on dual action approaches to tackling the mounting health problem of resistance by human pathogenic bacteria to antibacterial agents. In particular the areas reviewed include the use of two drugs in combination, dual action prodrugs, and dual action drugs (or hybrid drugs).
Bremner
John B
JB
Department of Chemistry, University of Wollongong, Wollongong, NSW, 2522, Australia. john_bremner@uow.edu.au
Ambrus
Joseph I
JI
Samosorn
Siritron
S
D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D008958:Models, Molecular; D011355:Prodrugs; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D011355:Prodrugs