title: Peroxide bond-dependent antiplasmodial specificity of artemisinin and OZ277 (RBx11160).
abstract: Using nonperoxidic analogs of artemisinin and OZ277 (RBx11160), the strong in vitro antiplasmodial activities of the latter two compounds were shown to be peroxide bond dependent. In contrast, the weak activities of artemisinin and OZ277 against six other protozoan parasites were peroxide bond independent. These data support the iron-dependent artemisinin alkylation hypothesis.
authors.affiliation: Swiss Tropical Institute, Basel, Switzerland.
authors.forename: Marcel
authors.initials: M
authors.lastname: Kaiser
authors.forename: Sergio
authors.initials: S
authors.lastname: Wittlin
authors.forename: Angela
authors.initials: A
authors.lastname: Nehrbass-Stuedli
authors.forename: Yuxiang
authors.initials: Y
authors.lastname: Dong
authors.forename: Xiaofang
authors.initials: X
authors.lastname: Wang
authors.forename: Andrew
authors.initials: A
authors.lastname: Hemphill
authors.forename: Hugues
authors.initials: H
authors.lastname: Matile
authors.forename: Reto
authors.initials: R
authors.lastname: Brun
authors.forename: Jonathan L
authors.initials: JL
authors.lastname: Vennerstrom
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D037621:Artemisinins / Q000737:chemistry / Q000494:pharmacology*; D056890:Eukaryota / Q000145:classification / Q000187:drug effects*; D006573:Heterocyclic Compounds, 1-Ring / Q000737:chemistry / Q000494:pharmacology*; D007501:Iron / Q000378:metabolism; D021261:Parasitic Sensitivity Tests; D010545:Peroxides / Q000737:chemistry* / Q000494:pharmacology; D010963:Plasmodium falciparum / Q000187:drug effects; D012717:Sesquiterpenes / Q000737:chemistry / Q000494:pharmacology*; D013141:Spiro Compounds / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000962:Antimalarials; D037621:Artemisinins; D006573:Heterocyclic Compounds, 1-Ring; D010545:Peroxides; D012717:Sesquiterpenes; D013141:Spiro Compounds; C489136:arterolane; C055261:deoxyartemisinin; D007501:Iron