Decorporation of plutonium by pulmonary administration of Ca-DTPA dry powder: a study in rat after lung contamination with different plutonium forms.
This study evaluates the decorporation efficacy of a pulmonary administration of a new Ca-DTPA (diethylenetriaminepentaacetic acid) dry powder (18 micromol kg(-1) of body mass) after pulmonary contamination of rats with different Pu compounds. After inhalation of PuO2, a delayed intratracheal administration of DTPA cannot reduce significantly the retention of Pu in the lungs but limits its transfer in liver and skeleton. After pulmonary contamination by Pu nitrate, early insufflation of the DTPA powder appears twice as more efficient than an i.v injection of DTPA (30 micromol kg(-1)) to reduce Pu retention in the lungs and is as effective as i.v. injection to limit the extrapulmonary deposit. In contrast, a delayed administration of DTPA cannot reduce the lung or extrapulmonary retention. In conclusion, the improvement of aerodynamic properties of DTPA powder leads to an increase of DTPA amount deposited in the lungs and enhances the body decorporation.
Sérandour
A L
AL
CEA/DSV/DRR, Laboratoire de Radiotoxicologie, BP 12, 91680 Bruyères-Le-Châtel, France. anne-laure.serandour@cea.fr
Tsapis
N
N
Gervelas
C
C
Grillon
G
G
Fréchou
M
M
Deverre
J R
JR
Bénech
H
H
Fattal
E
E
Fritsch
P
P
Poncy
J L
JL
D000280:Administration, Inhalation; D000396:Air Pollutants, Radioactive / Q000506:poisoning; D000818:Animals; D002614:Chelating Agents / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D019570:Inhalation Exposure; D008297:Male; D008657:Metabolic Clearance Rate / Q000187:drug effects; D004369:Pentetic Acid / Q000008:administration & dosage*; D011005:Plutonium / Q000008:administration & dosage / Q000302:isolation & purification / Q000493:pharmacokinetics* / Q000506:poisoning*; D011208:Powders; D011832:Radiation Injuries / Q000209:etiology / Q000378:metabolism* / Q000517:prevention & control*; D011837:Radiation-Protective Agents / Q000008:administration & dosage; D051381:Rats; D017207:Rats, Sprague-Dawley; D016896:Treatment Outcome
D000396:Air Pollutants, Radioactive; D002614:Chelating Agents; D011208:Powders; D011837:Radiation-Protective Agents; D011005:Plutonium; D004369:Pentetic Acid