Letrozole versus clomiphene citrate: which is better for ovulation induction?
Letrozole is at least as effective as clomiphene for inducing ovulation and achieving pregnancy in patients with polycystic ovarian syndrome. Potential advantages of letrozole include reduced multiple pregnancies, absence of antiestrogenic adverse effects, and the subsequent need for less intensive monitoring.
Casper
Robert F
RF
Professor, Division of Reproductive Sciences, Department of Obstetrics and Gynecology, University of Toronto, Toronto, Canada. Electronic address: rfcasper@aol.com.
D000328:Adult; D047072:Aromatase Inhibitors / Q000627:therapeutic use*; D002996:Clomiphene / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005300:Fertility Agents, Female / Q000627:therapeutic use*; D006801:Humans; D000077289:Letrozole; D009570:Nitriles / Q000627:therapeutic use*; D010060:Ovulation / Q000502:physiology; D010062:Ovulation Induction / Q000379:methods*; D011085:Polycystic Ovary Syndrome / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D011247:Pregnancy; D018873:Pregnancy Rate; D016896:Treatment Outcome; D014230:Triazoles / Q000627:therapeutic use*
D047072:Aromatase Inhibitors; D005300:Fertility Agents, Female; D009570:Nitriles; D014230:Triazoles; D002996:Clomiphene; D000077289:Letrozole