title: Leukocyte podosomes sense their way through the endothelium.
abstract: Whether leukocytes can transmigrate through endothelial cells, rather than between them, is controversial. In this issue, Carman et al. (2007) demonstrate that lymphocytes can extend podosomes to palpate endothelial cells searching for areas permissive for transcellular diapedesis.
authors.affiliation: Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA.
authors.forename: Andrés
authors.initials: A
authors.lastname: Hidalgo
authors.forename: Paul S
authors.initials: PS
authors.lastname: Frenette
mesh_terms: D002465:Cell Movement; D004730:Endothelium, Vascular / Q000276:immunology*; D006801:Humans; D007962:Leukocytes / Q000276:immunology*