Single nucleotide polymorphisms and haplotypes of the genes encoding the CYP1B1 in Korean women: no association with advanced endometriosis.
OBJECTIVE
To investigate whether single nucleotide polymorphisms and its haplotypes of gene encoding CYP1B1 are associated with the risk of advanced endometriosis in Korean women.


METHODS
We investigated 221 patients with histopathologically confirmed endometriosis rAFS stage III/IV and 188 control group women who were surgically proven to have no endometriosis. The genetic distribution of four different CYP1B1 polymorphisms at Ala119Ser, Leu432Val, Asp(449)(C>T), Asn453Ser were analyzed by polymerase chain reaction (PCR) and restriction fragment length polymorphism of PCR products. Haplotype analysis was also performed.


RESULTS
We found no overall association between each individual CYP1B1 genotype or haplotype and the risk of endometriosis. Also, the odds ratio of each haplotypes of CYP1B1 showed no association with the risk of endometriosis.


CONCLUSIONS
These results suggest that CYP1B1 genetic polymorphism may not be associated with development of advanced endometriosis in Korean women.
Cho
Yeon Jean
YJ
Department of Obstetrics and Gynecology, Kwandong University School of Medicine, Cheil General Hospital and Women's Healthcare Center, Seoul, Korea.
Hur
Sung Eun
SE
Lee
Ji Young
JY
Song
In Ok
IO
Moon
Hye-Sung
HS
Koong
Mi Kyoung
MK
Chung
Hye Won
HW
D000483:Alleles; D001189:Aryl Hydrocarbon Hydroxylases / Q000235:genetics*; D044466:Asian People; D016022:Case-Control Studies; D065633:Cytochrome P-450 CYP1B1; D004715:Endometriosis / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D007723:Korea; D015810:Linkage Disequilibrium; D016017:Odds Ratio; D010048:Ovarian Cysts / Q000235:genetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
D001189:Aryl Hydrocarbon Hydroxylases; C585496:CYP1B1 protein, human; D065633:Cytochrome P-450 CYP1B1