Comment on "Tequila, a neurotrypsin ortholog, regulates long-term memory formation in Drosophila".
Didelot et al. (Reports, 11 August 2006, p. 851) claimed that Drosophila Tequila (Teq) and human neurotrypsin are orthologs and concluded that deficient long-term memory after Teq inactivation indicates that neurotrypsin plays its essential role for human cognitive functions through a similar mechanism. Our analyses suggest that Teq and neurotrypsin are not orthologous, leading us to question their equivalent roles in higher brain function.
Sonderegger
Peter
P
Department of Biochemistry, University of Zurich, CH-8057 Zürich, Switzerland. Peter.Sonderegger@bioc.uzh.ch
Patthy
Laszlo
L
D000818:Animals; D029721:Drosophila Proteins / Q000737:chemistry* / Q000502:physiology; D004331:Drosophila melanogaster / Q000502:physiology*; D006801:Humans; D008568:Memory / Q000502:physiology*; D012697:Serine Endopeptidases / Q000737:chemistry* / Q000502:physiology
D029721:Drosophila Proteins; D012697:Serine Endopeptidases; C512782:Teq protein, Drosophila; C108493:neurotrypsin