title: Gallbladder carcinoma associated with anomalous pancreaticobiliary duct junction.
abstract: BACKGROUND
  Anomalous pancreaticobiliary ductal junction (APBDJ) is believed to be one of the risk factors for gallbladder carcinoma. The present study aims to delineate the gallbladder carcinoma characteristics associated with APBDJ.
  
  
  METHODS
  Patients with gallbladder carcinoma associated with APBDJ between August 1992 and February 2005 were retrospectively reviewed. Two types of APBDJ classifications were considered: right-angle type (C-P) and acute-angle type (P-C).
  
  
  RESULTS
  Ten of 218 patients (4.6%) with gallbladder carcinomas were associated with APBDJ. All patients were female with a mean age of 55.4 years (range 41 to 72 years). Gallstones were absent in nine patients. Seven patients (70%) had the P-C type and three patients (30%) had the C-P type. Survival differences between the P-C type and the C-P type of gallbladder carcinomas were noted (P=0.0269). Patients with incidentally detected gallbladder carcinoma had superior survival (P=0.0316).
  
  
  CONCLUSIONS
  Gallbladder carcinomas associated with APBDJ were significantly related to relatively young female patients without gallbladder stones. Survival outcomes in these patients were not different from those of gallbladder carcinoma without APBDJ. In particular, the P-C type of APBDJ seemed to be more associated with relatively advanced gallbladder carcinomas, and patients with incidentally detected gallbladder carcinomas with APBDJ had superior survival.
authors.affiliation: Department of Surgery, Yonsei University College of Medicine, Seoul, Korea. cmkang@yumc.yonsei.ac.kr
authors.forename: Chang Moo
authors.initials: CM
authors.lastname: Kang
authors.forename: Kyung Sik
authors.initials: KS
authors.lastname: Kim
authors.forename: Jin Sub
authors.initials: JS
authors.lastname: Choi
authors.forename: Woo Jung
authors.initials: WJ
authors.lastname: Lee
authors.forename: Byong Ro
authors.initials: BR
authors.lastname: Kim
mesh_terms: D000328:Adult; D000368:Aged; D001652:Bile Ducts / Q000002:abnormalities*; D015529:Choledochal Cyst / Q000150:complications; D005260:Female; D005706:Gallbladder Neoplasms / Q000150:complications* / Q000401:mortality / Q000473:pathology; D006801:Humans; D008875:Middle Aged; D010183:Pancreatic Ducts / Q000002:abnormalities*; D012307:Risk Factors; D015996:Survival Rate