title: Primary pulmonary rhabdomyosarcoma in adults: case report and review of literature.
abstract: A 38-year-old man, a chronic smoker, presented to us with a large left upper lobe mass lesion and left-sided pleural effusion. After resection, a residual mass remained. On histopathologic examination, a diagnosis of pleiomorphic rhabdomyosarcoma stage III of the lung was made. Chemotherapy using IRS (Intergroup Rhabdomyosarcoma Study) IV protocol with radiation therapy (RT) at week 9 was planned. The tumor progressed within 6 weeks of chemotherapy to involve the diaphragm and the pericardium (inoperable disease). Chemotherapy was abandoned, and we referred the patient to receive RT, which the patient refused; and he died of progressive disease 1 month later. The poor response to chemotherapy suggests that alternative treatment modalities including RT/second-look surgery or novel chemotherapeutic strategies should be tried in such a case.
authors.affiliation: Department of Medical Oncology, Institute Rotary Cancer Hospital, New Delhi, India. ajayajaygupta2002@rediffmail.com
authors.forename: Ajay
authors.initials: A
authors.lastname: Gupta
authors.forename: Mehar Chand
authors.initials: MC
authors.lastname: Sharma
authors.forename: Vinod
authors.initials: V
authors.lastname: Kochupillai
authors.forename: Ganesan
authors.initials: G
authors.lastname: Kichendasse
authors.forename: Anuradha
authors.initials: A
authors.lastname: Gupta
authors.forename: Surender
authors.initials: S
authors.lastname: Atri
authors.forename: Kunjehari
authors.initials: K
authors.lastname: Medhi
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D003131:Combined Modality Therapy; D003964:Diaphragm / Q000473:pathology; D017809:Fatal Outcome; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000628:therapy; D008297:Male; D010496:Pericardium / Q000473:pathology; D011878:Radiotherapy; D012208:Rhabdomyosarcoma / Q000000981:diagnostic imaging / Q000473:pathology* / Q000628:therapy; D014057:Tomography, X-Ray Computed
chemical_list: D000970:Antineoplastic Agents