Taking vesicular transport to the cilium.
Defects in protein trafficking within the cell body and cilia are thought to underlie the human disease Bardet-Biedl syndrome (BBS). In this issue, Nachury et al. (2007) reveal that a large complex of proteins implicated in BBS cooperates with Rabin8-the GTP exchange factor for the small GTPase Rab8-to promote cilia formation and presumably movement of membrane proteins from the cell into the cilium.
Leroux
Michel R
MR
Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC V5A 1S6, Canada. leroux@sfu.ca
D000818:Animals; D020788:Bardet-Biedl Syndrome / Q000378:metabolism*; D001692:Biological Transport; D002923:Cilia / Q000378:metabolism*; D005407:Flagella; D020558:GTP Phosphohydrolases / Q000378:metabolism; D006801:Humans; D008870:Microtubules / Q000378:metabolism; D008954:Models, Biological; D011485:Protein Binding; D021381:Protein Transport; D020691:rab GTP-Binding Proteins / Q000378:metabolism
D020558:GTP Phosphohydrolases; C082377:RAB8A protein, human; D020691:rab GTP-Binding Proteins