Neuroprotective strategies to avert seizure-induced neurodegeneration in epilepsy.
Neurodegeneration in limbic circuits is a hallmark feature of chronic temporal lobe epilepsy (TLE). Studies in experimental animal models and human patients indicate that seizure-induced neuronal injury involves some active, as well as passive cell death processes. Experimental approaches that inhibit active steps in cell death programs have been shown to reduce neuronal cell death and sclerosis, but not to prevent epileptogenesis in animal models of TLE. These findings suggest that we need additional research using both animal models and brain slices from human patients to understand the pathological mechanisms underlying seizure generation. Such comparative studies will also aid in evaluating the potential therapeutic value of inhibiting cell death in seizure disorders.
Naegele
Janice R
JR
Department of Biology, Room 257, Hall-Atwater Laboratory, Lawn Avenue, Wesleyan University, Middletown, CT 06459, USA. janaegele@wesleyan.edu
D000818:Animals; D001921:Brain / Q000473:pathology / Q000503:physiopathology; D002118:Calcium / Q000502:physiology; D016923:Cell Death / Q000502:physiology; D004249:DNA Damage / Q000502:physiology; D004260:DNA Repair / Q000502:physiology; D004195:Disease Models, Animal; D004833:Epilepsy, Temporal Lobe / Q000473:pathology / Q000503:physiopathology* / Q000628:therapy*; D019940:Genes, bcl-1 / Q000502:physiology; D015316:Genetic Therapy; D006801:Humans; D008959:Models, Neurological; D009410:Nerve Degeneration / Q000503:physiopathology / Q000517:prevention & control*; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D051381:Rats; D012107:Research Design; D012640:Seizures / Q000473:pathology / Q000503:physiopathology
D018696:Neuroprotective Agents; D002118:Calcium