Targeting farnesoid X receptor for liver and metabolic disorders.
The farnesoid X receptor (FXR) is a metabolic nuclear receptor expressed in the liver, intestine, kidney and adipose tissue. By regulating the expression and function of genes involved in bile acid (BA) synthesis, uptake and excretion, FXR has emerged as a key gene involved in the maintenance of cholesterol and BA homeostasis. FXR ligands are currently under clinical investigation for the treatment of cholestasis, dyslipidemic disorders and conditions of insulin resistance in type 2 diabetes and non-alcoholic steatohepatitis (NASH). Because activation of FXR impacts a considerable number of genes, development of FXR modulators that selectively regulate specific pathways will limit potentially undesirable side effects. Interaction of FXR with other BAs and xenobiotics sensors such as the constitutive androstane receptor and the pregnane X receptor might allow the development of combination therapies for liver and metabolic disorders.
Fiorucci
Stefano
S
Dipartimento di Medicina Clinica e Sperimentale, University of Perugia, Perugia, Italy. fiorucci@unipg.it
Rizzo
Gianni
G
Donini
Annibale
A
Distrutti
Eleonora
E
Santucci
Luca
L
D000818:Animals; D050197:Atherosclerosis / Q000378:metabolism; D001647:Bile Acids and Salts / Q000378:metabolism; D002779:Cholestasis / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000819:agonists* / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D008024:Ligands; D008099:Liver / Q000378:metabolism; D008107:Liver Diseases / Q000188:drug therapy* / Q000378:metabolism; D008659:Metabolic Diseases / Q000188:drug therapy* / Q000378:metabolism; D008954:Models, Biological; D018160:Receptors, Cytoplasmic and Nuclear / Q000819:agonists* / Q000737:chemistry / Q000378:metabolism; D014157:Transcription Factors / Q000819:agonists* / Q000737:chemistry / Q000378:metabolism; D000099150:Receptor, Farnesoid X-Activated
D001647:Bile Acids and Salts; D004268:DNA-Binding Proteins; D008024:Ligands; D018160:Receptors, Cytoplasmic and Nuclear; D014157:Transcription Factors; D000099150:Receptor, Farnesoid X-Activated