The tissue factor-factor VIIa complex: procoagulant activity, regulation, and multitasking.
Greater understanding of the cellular interactions associated with tissue factor (TF), activated factor (F) VII and TF-FVIIa complexes is likely to provide considerable clinical benefit. This article reviews current knowledge on the function and regulation of TF and its role in a range of biological processes, including hemostasis, thrombosis and inflammation.
Monroe
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DM
Center for Thrombosis and Hemostasis, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. dmonroe@med.unc.edu
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D001777:Blood Coagulation / Q000502:physiology*; D015942:Factor VIIa / Q000737:chemistry / Q000502:physiology*; D006487:Hemostasis; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000209:etiology; D008074:Lipoproteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology; D008958:Models, Molecular; D046912:Multiprotein Complexes; D011499:Protein Processing, Post-Translational; D015398:Signal Transduction; D012995:Solubility; D013925:Thromboplastin / Q000737:chemistry / Q000502:physiology*; D013927:Thrombosis / Q000097:blood / Q000209:etiology
D008074:Lipoproteins; D046912:Multiprotein Complexes; C051928:lipoprotein-associated coagulation inhibitor; D013925:Thromboplastin; D015942:Factor VIIa