title: Relationship between volatile odorous substances and production of avermectins by Streptomyces avermitilis.
abstract: The time course of production of odorous compounds, i.e. geosmin and oxolones, and of avermectins was determined during the cultivation of S. avermitilis in flasks, 1- and 50-L fermentors. The amount of the antibiotics increased with increasing cultivation time up to more than 2 g/L while the concentration of geosmin rose to more than 4 mg/L. Cultivation without reflux condenser resulted in a lower product formation due to the higher stripping of geosmin. A relatively tight correlation was found between the production of geosmin and the production of avermectins. The production of oxolones peaked on cultivation days 3-5, the sum of oxolones being 60 microg/L. Subsequently, the production dropped below a measurable level. This can be explained as being due to the inhibition of oxolone production by geosmin.
authors.affiliation: Institute ofMicrobiology, Academy of Sciences of the Czech Republic, 142 20 Prague. rezanka@biomed.cas.cz
authors.forename: T
authors.initials: T
authors.lastname: Rezanka
authors.forename: M
authors.initials: M
authors.lastname: Sobotka
authors.forename: A
authors.initials: A
authors.lastname: Prell
authors.forename: K
authors.initials: K
authors.lastname: Sigler
mesh_terms: D001709:Biotechnology / Q000379:methods; D005285:Fermentation; D008401:Gas Chromatography-Mass Spectrometry; D007559:Ivermectin / Q000031:analogs & derivatives* / Q000378:metabolism; D007700:Kinetics; D009284:Naphthols / Q000378:metabolism*; D009812:Odorants / Q000032:analysis*; D013302:Streptomyces / Q000254:growth & development / Q000378:metabolism*; D014835:Volatilization
chemical_list: D009284:Naphthols; D007559:Ivermectin; C019264:avermectin; C001278:geosmin