title: Stevens-Johnson syndrome in children receiving phenobarbital therapy and cranial radiotherapy.
abstract: Stevens-Johnson syndrome (SJS) is a severe cutaneous eruption that most often appears as an adverse reaction to medication. In this report, we present two children with brain tumour who developed SJS while receiving cranial irradiation and anticonvulsant therapy with phenobarbital. Concomitant application of these two therapies may play an important role in the occurrence of the disease.
authors.affiliation: Department of Paediatrics, Pediatric Oncology, Università Cattolica del Sacro Cuore, Policlinico A. Gemelli, Rome, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Ruggiero
authors.forename: Paola Sabrina
authors.initials: PS
authors.lastname: Buonuomo
authors.forename: Palma
authors.initials: P
authors.lastname: Maurizi
authors.forename: Maria Giuseppina
authors.initials: MG
authors.lastname: Cefalo
authors.forename: Maria Pia
authors.initials: MP
authors.lastname: Cefalo
authors.forename: Mirta
authors.initials: M
authors.lastname: Corsello
authors.forename: Riccardo
authors.initials: R
authors.lastname: Riccardi
mesh_terms: D000927:Anticonvulsants / Q000009:adverse effects*; D001932:Brain Neoplasms / Q000150:complications* / Q000532:radiotherapy / Q000601:surgery; D002648:Child; D003131:Combined Modality Therapy / Q000009:adverse effects; D016371:Cranial Irradiation / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008527:Medulloblastoma / Q000150:complications* / Q000532:radiotherapy / Q000601:surgery; D010634:Phenobarbital / Q000009:adverse effects*; D013262:Stevens-Johnson Syndrome / Q000209:etiology*; D016896:Treatment Outcome
chemical_list: D000927:Anticonvulsants; D010634:Phenobarbital