[Experimental investigations of the analgesic activity of fentanyl and the non-opiodal agents -clonidine and isradipine, and protease inhibitors].
The analgesic activity of clonidine, isradipine, antagosane (aprotinine), transamine, and their combinations with fentanyl in subanalgesic doses was experimentally studied on mice, by using the tail-flick test. Analgesic activity was found in clonidine, antagosane, and transamine. A combination of fentanyl used in subanalgesic doses and clonidine, isradipine, antagosane, or transamine had supertotal analgesic activity. The findings serve as a basis for effectively making up a component of analgesia during anesthetic support at surgery made in patients with baseline sympathicotonia, ischemia/reperfusion syndrome, and a systemic inflammatory reaction.
Pyregov
A V
AV
Aliautdin
R N
RN
Petrov
V E
VE
Pivovarova
G M
GM
Siluianova
E V
EV
Gur'ianov
V A
VA
D000698:Analgesia / Q000379:methods*; D000700:Analgesics / Q000494:pharmacology*; D000701:Analgesics, Opioid / Q000494:pharmacology*; D000818:Animals; D003000:Clonidine / Q000494:pharmacology; D005283:Fentanyl / Q000494:pharmacology*; D017275:Isradipine / Q000494:pharmacology; D051379:Mice; D010147:Pain Measurement; D011480:Protease Inhibitors / Q000494:pharmacology*
D000700:Analgesics; D000701:Analgesics, Opioid; D011480:Protease Inhibitors; D003000:Clonidine; D005283:Fentanyl; D017275:Isradipine