title: [Effects of copper supplementation on lipid profiles in elderly patients with copper deficiency].
abstract: OBJECTIVE
  The purpose of this study was to examine the effects of copper supplementation on lipid profiles in elderly patients with copper deficiency.
  
  
  METHODS
  Nine long-term bed-ridden, patients (5 men and 4 women, mean age 83.3+/-8.7 years old) with severe copper deficiency, who had a serum copper of 15 microg/dL or less (normal range 70-140 microg/dL), had their diets supplemented with copper sulfate (3 mg/day) over 12 weeks in addition to their diet of only one kind of enteral food with a low concentration of copper. Copper, ceruloplasmin, total cholesterol (TC), triacylglycerides (TG), HDL-cholesterol (HDL-C), c-reactive protein (CRP), creatinine (Cr), zinc (Zn) and albumin (Alb) in the serum were measured before, 4 weeks and 12 weeks after copper supplementation.
  
  
  RESULTS
  Serum copper and ceruloplasmin were significantly increased at 4 weeks after copper supplementation. TG was significantly increased at 4 weeks after copper supplementation, but at 12 weeks the increase of TG was not significant. TC, HDL-C, CRP, Cr, Zn and Alb were not changed by copper supplementation.
  
  
  CONCLUSIONS
  TG was transiently increased by copper supplementation in elderly patients with copper deficiency. TC and HDL-C were not changed by copper supplementation.
authors.affiliation: Department of General Medicine, Gunma University Hospital.
authors.forename: Etsuo
authors.initials: E
authors.lastname: Kawada
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Moridaira
authors.forename: Hiroko
authors.initials: H
authors.lastname: Sato
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Ukita
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Itoh
authors.forename: Takeshi
authors.initials: T
authors.lastname: Tatsumi
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Kogure
authors.forename: Junichi
authors.initials: J
authors.lastname: Tamura
authors.forename: Hironosuke
authors.initials: H
authors.lastname: Sakamoto
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002570:Ceruloplasmin / Q000032:analysis; D003300:Copper / Q000008:administration & dosage* / Q000097:blood / Q000172:deficiency*; D019587:Dietary Supplements; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D014280:Triglycerides / Q000097:blood
chemical_list: D008055:Lipids; D014280:Triglycerides; D003300:Copper; D002570:Ceruloplasmin