title: Increased splenic fluorodeoxyglucose uptake in a patient with granulomatous angitis.
abstract: Although utility of 18F-fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) has been rehearsed in large vessel vasculitides, it is not known if small vessel vasculitides are also associated with increased FDG uptake. Hereby described is a 64-year-old female patient with prolonged fever and splenomegaly, which was depicted as a hot area in FDG-PET. Splenectomy disclosed microaneurysms, giant cell granuloma, perivascular leukocytic infiltration with fibrinoid necrosis, consistent with granulomatous angitis. Serum myeloperoxidase-antineutrophil cytoplasmic antibody was positive. The present case illustrates that vasculitides affecting small vessels present increased FDG uptake as do those affecting large vessels.
authors.affiliation: Department of Internal Medicine, Kurume University School of Medicine. maruoka@med.kurume-u.ac.jp
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Maruoka
authors.forename: Takeharu
authors.initials: T
authors.lastname: Koga
authors.forename: Masaaki
authors.initials: M
authors.lastname: Takeo
authors.forename: Seiyo
authors.initials: S
authors.lastname: Honda
authors.forename: Kentaro
authors.initials: K
authors.lastname: Yuge
authors.forename: Takaaki
authors.initials: T
authors.lastname: Fukuda
authors.forename: Hisamichi
authors.initials: H
authors.lastname: Aizawa
mesh_terms: D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics*; D006801:Humans; D008875:Middle Aged; D049268:Positron-Emission Tomography / Q000295:instrumentation; D011859:Radiography; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics*; D013154:Spleen / Q000378:metabolism*; D013163:Splenomegaly / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology; D016896:Treatment Outcome; D020293:Vasculitis, Central Nervous System / Q000150:complications / Q000378:metabolism* / Q000473:pathology / Q000628:therapy
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18