title: FGFR3 mutations in epidermal nevi and seborrheic keratoses: lessons from urothelium and skin.
abstract: Somatic FGFR3 mutations have been reported in various cancers such as urothelial carcinoma. Evidence is growing that these mutations are also involved in the pathogenesis of benign acanthotic skin tumors such as epidermal nevi and seborrheic keratoses. The report by Hernandez et al. strongly supports this concept. However, further studies are required for a better pathogenetic understanding of FGFR3 related tumors in urothelium and skin.
authors.affiliation: Department of Dermatology, University of Regensburg, 93042 Regensburg, Germany. christian.hafner@klinik.uni-regensburg.de
authors.forename: Christian
authors.initials: C
authors.lastname: Hafner
authors.forename: Arndt
authors.initials: A
authors.lastname: Hartmann
authors.forename: Thomas
authors.initials: T
authors.lastname: Vogt
mesh_terms: D004273:DNA, Neoplasm / Q000235:genetics; D018095:Germ-Line Mutation / Q000235:genetics*; D006801:Humans; D017492:Keratosis, Seborrheic / Q000235:genetics* / Q000378:metabolism; D009506:Nevus / Q000235:genetics* / Q000378:metabolism; D051498:Receptor, Fibroblast Growth Factor, Type 3 / Q000235:genetics* / Q000378:metabolism; D012867:Skin / Q000378:metabolism; D012878:Skin Neoplasms / Q000235:genetics* / Q000378:metabolism; D001749:Urinary Bladder Neoplasms / Q000235:genetics* / Q000378:metabolism; D019459:Urothelium / Q000378:metabolism
chemical_list: D004273:DNA, Neoplasm; C496365:FGFR3 protein, human; D051498:Receptor, Fibroblast Growth Factor, Type 3