title: [The leishmaniasis - a parasitel infection as differential diagnosis of malignant tumours of oral mucosa. A case report and review of literature].
abstract: Although parasitel infections in northern Europe are rare, it must be considered as differential diagnosis of malignant tumours of mucous membrane. With increasing tourisms in endemic areas, infections with parasite pathogen are spreading in non-endemic areas as well. In this case a mucous membrane malignancy with clinical feature of ulcer on unusual location was imitated. In this reported case the patient suffers with hepatitis c, causing cirrhosis of the liver and making a liver transplantation necessary. In this patient a history of a leishmaniosis which had been treated successful by the tropical institute is reported, but because of a new actually leishmaniosis-infection a liver transplantation is contraindicated. Under oral therapy with Miltefosin (IMPADIVO) a remission was successful. The leishmaniosis is a classical tropical disease. WHO reported a morbidity of nearly 12 million people in 88 countries around the world especially in tropical areas. Repeatedly infections in northern Europe caused by the phlebotonus-sandflies are described. Therefore leishmaniosis must be considered as differential diagnosis in suspect lesions of mucous membrane.
authors.affiliation: Ruhr-Universität Bochum, Knappschaftskrankenhaus Bochum-Langendreer, Universitätsklinik für Mund-, Kiefer- und Plastische Gesichtschirurgie, In der Schornau 23-25, 44892 Bochum, Germany. anwy@gmx.de
authors.forename: Andreas
authors.initials: A
authors.lastname: Wysluch
authors.forename: Florian
authors.initials: F
authors.lastname: Sommerer
authors.forename: Hamid
authors.initials: H
authors.lastname: Ramadan
authors.forename: Denys
authors.initials: D
authors.lastname: Loeffelbein
authors.forename: Klaus-Dietrich
authors.initials: KD
authors.lastname: Wolff
authors.forename: Frank
authors.initials: F
authors.lastname: Hölzle
mesh_terms: D000818:Animals; D003131:Combined Modality Therapy; D003937:Diagnosis, Differential; D019698:Hepatitis C, Chronic / Q000150:complications; D006644:Histiocytes / Q000473:pathology; D006801:Humans; D018314:Leishmania infantum; D007898:Leishmaniasis, Visceral / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D008103:Liver Cirrhosis / Q000150:complications; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000473:pathology / Q000601:surgery; D009062:Mouth Neoplasms / Q000175:diagnosis*; D009894:Opportunistic Infections / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D019226:Oral Ulcer / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D010767:Phosphorylcholine / Q000031:analogs & derivatives / Q000627:therapeutic use; D012008:Recurrence; D013280:Stomatitis / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery
chemical_list: D010767:Phosphorylcholine; C039128:miltefosine