[Chromosomal aberration in vulvar squamous cell carcinoma analyzed by comparative genomic hybridization].
OBJECTIVE
Vulvar squamous cell carcinoma (VSCC) accounts for about 80%-90% of female vulvar malignant tumors, but the etiology is still unclear. This study was to identify genetic alteration in VSCC by comparative genomic hybridization (CGH).


METHODS
The genomic imbalance, that is, gains or losses of chromosomes, in 21 cases of vulvar squamous cell carcinoma was detected by CGH.


RESULTS
The common chromosomal alterations in VSCC included gains of chromosomes 3q, 8q and 12q, and losses of chromosomes 4p and 3p.


CONCLUSIONS
There are multiple chromosomal aberrations in VSCC. The amplification of the tumor suppressor genes and loss of the oncogenes on these regions may be involved in the development and progression of VSCC.
Ouyang
Ling
L
Department of Obstetrics and Gynecology, Shengjing Hospital, China Medical University, Shenyang, Liaoning 110004, P. R. China. ouyang1964@163.com
Zhang
Shu-Lan
SL
Chen
Rong-Li
RL
Li
Bo
B
Chen
Li-Li
LL
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D002869:Chromosome Aberrations; D002872:Chromosome Deletion; D002881:Chromosomes, Human, Pair 12; D002893:Chromosomes, Human, Pair 3; D002894:Chromosomes, Human, Pair 4; D002898:Chromosomes, Human, Pair 8; D055028:Comparative Genomic Hybridization / Q000379:methods*; D005260:Female; D006801:Humans; D008875:Middle Aged; D014846:Vulvar Neoplasms / Q000235:genetics*