title: Clinical prognostic factors for ovarian metastasis in women with gastric cancer.
abstract: OBJECTIVE
  Krukenberg's tumor is considered to be a metastatic carcinoma to the ovary derived from a primary malignancy, usually from the gastrointestinal tract. This retrospective study tries to evaluate the clinicopathologic characteristics of ovarian metastasis in female gastric cancer and to define the prognostic factors.
  
  
  METHODS
  Of 1,890 female patients with gastric cancers, 37 patients with metastatic ovarian carcinomas were analyzed.
  
  
  RESULTS
  Patients with ovarian metastasis were younger in age, higher in primary tumor location, and far advanced in depth of invasion and lymph node metastases. Ovarian metastasis was largely related to the peritoneal seeding, which was statistically significant on survival time. A multivariate analysis of prognostic factors indicated that the presence of peritoneal seeding was the only significant independent factor. The young female patients with far advanced gastric cancer were vulnerable to recurrence of ovarian metastasis and were considered to undergo prophylactic oophorectomy with gastrectomy. The prognosis of ovarian metastasis is dismal, because this is frequently associated with the peritoneal disseminations.
  
  
  CONCLUSIONS
  It is essential to treat the peritoneal disseminations in order to improve the survival rate of female gastric cancer patients with ovarian metastasis.
authors.affiliation: Department of Surgery, Ulsan University College of Medicine, Asan Medical Center, 388-1 Pungnap-2dong, Songpa-gu, Seoul 138-736, Korea. jhyook@amc.seoul.kr
authors.forename: Jeong H
authors.initials: JH
authors.lastname: Yook
authors.forename: Sung T
authors.initials: ST
authors.lastname: Oh
authors.forename: Byung S
authors.initials: BS
authors.lastname: Kim
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007725:Krukenberg Tumor / Q000175:diagnosis* / Q000473:pathology / Q000556:secondary*; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000556:secondary*; D011379:Prognosis; D012189:Retrospective Studies; D012306:Risk; D013274:Stomach Neoplasms / Q000473:pathology*