Automated red cell exchange procedures in patients with sickle cell disease.
In automated red cell exchange, about 60% of the patient's red blood cells are exchanged via apheresis for those of the donor. We report the outcome of 83 patients with sickle cell anemia (48 women and 35 men; age range, 17-49 years) who underwent a total of 196 apheresis procedures between December 2003 and October 2006 at our institution. We found that automated red cell exchange involving a reduced citrate infusion rate may provide benefit in the prevention or treatment of vaso-occlusive complications in patients with sickle cell disease and may be associated with protean effects on biochemical dynamics.
Kozanoglu
Ilknur
I
Department of Physiology, Baskent University, Faculty of Medicine, 06490-Ankara, Turkey.
Boga
Can
C
Ozdogu
Hakan
H
Sezgin
Nurzen
N
Kizilkilic
Ebru
E
Kural
Mahmut
M
D000293:Adolescent; D000328:Adult; D000755:Anemia, Sickle Cell / Q000150:complications / Q000628:therapy*; D001157:Arterial Occlusive Diseases / Q000517:prevention & control; D001331:Automation; D001781:Blood Component Removal / Q000009:adverse effects / Q000379:methods*; D019343:Citric Acid; D017707:Erythrocyte Transfusion / Q000009:adverse effects / Q000379:methods*; D004912:Erythrocytes; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D016896:Treatment Outcome
D019343:Citric Acid