[Use of preoperative glucocorticoid to reduce risk of complications after esophagectomy for carcinoma of the esophagus: meta-analysis].
OBJECTIVE
Preoperative glucocorticoid administration has been proposed to reduce postoperative morbidity. This is not frequently done before esophageal resection because of insufficient knowledge on its effectiveness. The purpose was to assess the effects of preoperative glucocorticoid administration in adults undergoing esophageal resection for esophageal carcinoma.


METHODS
Studies were identified by searching the Cochrane Controlled Trials Register, Medline, Embase, Scielo and Cochrane Library, and by a manual search for relevant articles. In this systematic review, the last search for clinical trials was performed in December 2005. This review included randomized studies of patients with potentially resectable carcinomas of the esophagus that compared preoperative glucocorticoid administration with placebo. Data were collected by the reviewer, and quality of the trial was assessed using Jadad scoring. Odds ratio with 95% confidence intervals was used to assess the significance of the difference between treatment arms.


RESULTS
Four randomized trials involving 169 patients were found. There were no differences in postoperative mortality, anastomotic leakage, hepatic and renal failure between the glucocorticoid and placebo groups. There were fewer postoperative respiratory complications (95% CI= 0.09-0.46), sepsis (95% CI= 0.10-0.81), and total postoperative complications (95% CI=0.06-0.23) with preoperative glucocorticoid administration.


CONCLUSIONS
Prophylactic administration of glucocorticoids is associated with decreased postoperative complications.
Raimondi
Antônio Marcos
AM
Hospital das Clínicas, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo e no Hospital São Paulo da Universidade Federal de São Paulo. raimond11@terra.com.br
D000328:Adult; D018849:Controlled Clinical Trials as Topic; D004938:Esophageal Neoplasms / Q000601:surgery*; D016629:Esophagectomy; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D008775:Methylprednisolone / Q000627:therapeutic use*; D016017:Odds Ratio; D011183:Postoperative Complications / Q000517:prevention & control*; D011300:Preoperative Care; D012307:Risk Factors
D005938:Glucocorticoids; D008775:Methylprednisolone