title: Alpha-1-antitrypsin phenotypes in Saudi Arabia: A study in the central province.
abstract: This study was conducted on 204 plasma samples obtained from Saudis living in the central province of Saudi Arabia, to determine the prevalence of alpha-1-antitrypsin (alpha1AT) phenotypes. The alpha1AT phenotypes were separated by isoelectric focusing on ampholine gels (pH 4-5). The prevalences of PiMM, MS, MZ, SZ, and ZZ were 0.8676, 0.0931, 0.0245, 0.0098, and 0.0049, respectively. The gene frequencies of the alpha1AT variants, i.e.., PiM, PiS, and PiZ, were 0.9265, 0.0515, 0.022, respectively. We describe and compare our results in a Saudi population with those reported for other populations.
authors.affiliation: Departments of Biochemistry, College of Science, College of Medicine, and Department of Nutrition, College of Allied Medical Sciences, King Saud University, Riyadh, Saudi Arabia.
authors.forename: A S
authors.initials: AS
authors.lastname: Warsy
authors.forename: M A
authors.initials: MA
authors.lastname: El-Hazmi
authors.forename: S H
authors.initials: SH
authors.lastname: Sedrani
authors.forename: M
authors.initials: M
authors.lastname: Kinhal