Effect of Ginkgo biloba extract (EGb 761) on the healing of left colonic anastomoses in rat.
BACKGROUND
The aim of this study was to assess the effect of Ginkgo biloba extract (EGb 761) on healing of experimental colonic anastomoses in a rat model.


METHODS
Rats were divided into four groups: postoperative day (POD) 3 untreated control group, POD 3 EGb 761 group, POD 7 untreated control group, and POD 7 EGb 761 group. In the oral EGb 761 groups, the agent was given at 9.6 mg daily per orogastric route using a 4-F fine feeding catheter. We measured bursting pressures and hydroxyproline content and histologically examined the resected anastomoses on POD 3 and POD 7.


RESULTS
The bursting pressures increased more in the EGb 761 group than in the untreated control group on POD 3, but this difference was not statistically significant. Hydroxyproline content was higher in the EGb 761 group than in the untreated control group on POD 3, and this difference was statistically significant. Anastomosis bursting pressure values and hydroxyproline contents were significantly higher in the EGb 761 group than in the untreated control group on POD 7. Histological examination showed greater fibroblastic activity in the EGb 761 group than in the untreated control group on POD 3. There was no significant difference in anastomotic polimorphonuclear leukocyte, mononuclear cells and blood vessel neodevelopment between the POD 3 groups, but there was significant difference in fibroblastic activity and blood vessel neodevelopment between the POD 7 groups.


CONCLUSIONS
These results showed us that EGb 761 administration resulted in enhanced stability of colonic anastomoses during the first postoperative week.
Kisli
Erol
E
Department of General Surgery, School of Medicine, Yüzüncü Yil University, Van, Turkey. erolkisli@hotmail.com
Ozdemir
Hülya
H
Kösem
Mustafa
M
Sürer
Hatice
H
Ciftçi
Ali
A
Kanter
Mehmet
M
D000284:Administration, Oral; D000714:Anastomosis, Surgical; D000818:Animals; D003106:Colon / Q000473:pathology / Q000601:surgery*; D020441:Ginkgo biloba; D006874:Hydrostatic Pressure; D006909:Hydroxyproline / Q000032:analysis; D008297:Male; D023421:Models, Animal; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D014945:Wound Healing / Q000187:drug effects*; D000096983:Ginkgo Extract
D006909:Hydroxyproline; D010936:Plant Extracts; C063170:Ginkgo biloba extract; D000096983:Ginkgo Extract