[Detection for alpha-glucosidase-inhibiting polyhydroxyalkaloid ingredients of Commelina communis L. by ESIMS].
For detecting polyhydroxyalkaloids-type alpha-glucosidase-inhibiting ingredients of Commelina communis L grown in China, total alkaloids were obtained from the plant by extraction with water, removal of precipitation after the addition of alcohol, enrichment and purification by ion exchange resin and sephadex LH 20 chromatography. Polyhydroxyalkaloids in the total alkaloids were detected by ion trap electron-spray ionization mass spectra (ESIMS). Several reported and unreported polyhydroxyalkaloids in the plant were detected from the material collected from Jixi county, Anhui province. The crude drug growing in China contains alpha-glucosidase-inhibiting polyhydroxyalkaloids and can be used to therapy in diabetes.
Wang
Guo-ping
GP
Xiu-ning County TCM Hospital of Anhui Province, Huangshan 245400, China.
Deng
Mei-yong
MY
Zhou
Guang-xiong
GX
Huang
Mei-yan
MY
Ye
Wen-cai
WC
Ye
Chun-ling
CL
D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification; D034822:Commelina / Q000737:chemistry*; D065089:Glycoside Hydrolase Inhibitors; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000302:isolation & purification; D015394:Molecular Structure; D008970:Molecular Weight; D010946:Plants, Medicinal / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods; D000520:alpha-Glucosidases / Q000737:chemistry* / Q000302:isolation & purification
D000470:Alkaloids; D065089:Glycoside Hydrolase Inhibitors; D007004:Hypoglycemic Agents; D000520:alpha-Glucosidases