title: Adenoid basal carcinoma arising in the cervical polyp: an immunohistochemical study of stromal cells.
abstract: Adenoid basal carcinomas of the uterine cervix are uncommon neoplasms and generally run a favorable clinical course. Although it is well known that these tumors do not evoke the stromal reaction, we immunohistochemically examined a stromal reaction in a case of adenoid basal carcinoma. A 40-year-old woman was found to have a cervical polyp during a medical checkup and underwent polypectomy. Histological examination revealed the finding of adenoid basal carcinoma. Immunohistochemically, a smaller number of CD34-positive and CD31-negative stromal cells, namely fibroblasts, in the stroma of tumor center than in normal cervical stroma were observed. On the other hand, alpha-smooth muscle actin-positive and h-caldesmon-negative stromal cells, namely myofibroblasts, were completely absent in the stroma of tumor center. Finally, our preliminary report suggests that the decrease of CD34-positive fibroblasts in adenoid basal carcinoma may show an early stromal reaction to tumor invasion. Gynecologists and pathologists should bear in mind that adenoid basal carcinoma may arise in a cervical polyp.
authors.affiliation: Department of Pathology, Kochi Red Cross Hospital, Kochi, Japan. nkurodakrch@yahoo.co.jp
authors.forename: Naoto
authors.initials: N
authors.lastname: Kuroda
authors.forename: Kohki
authors.initials: K
authors.lastname: Hirano
authors.forename: Masahiko
authors.initials: M
authors.lastname: Ohara
authors.forename: Takashi
authors.initials: T
authors.lastname: Hirouchi
authors.forename: Keiko
authors.initials: K
authors.lastname: Mizuno
authors.forename: Ayumi
authors.initials: A
authors.lastname: Kubo
authors.forename: Hideaki
authors.initials: H
authors.lastname: Enzan
mesh_terms: D000328:Adult; D018952:Antigens, CD34 / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000378:metabolism*; D003528:Carcinoma, Adenoid Cystic / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D018295:Neoplasms, Basal Cell / Q000473:pathology*; D011127:Polyps / Q000473:pathology*; D017154:Stromal Cells / Q000378:metabolism*; D002583:Uterine Cervical Neoplasms / Q000473:pathology*
chemical_list: D018952:Antigens, CD34; D014408:Biomarkers, Tumor