Pregnancy-induced hypertension and perinatal mortality.
OBJECTIVE
To examine the association between pregnancy-induced hypertension (PIH) and perinatal mortality.


METHODS
A population-based, retrospective, cohort study was conducted based on 16,936 pregnancies delivered between January 1, 1989, and December 31, an infant 1990, in Suzhou, China. PIH growth was classified as gestational hypertension, preeclampsia or severe preeclampsia.


RESULTS
The perinatal mortality was 10.2 per thousand in normotensive women, 10.3 per thousand in women with gestational hypertension, 17.8 per thousand in women with preeclampsia and 37.0 per thousand in women with severe preeclampsia. Severe preeclampsia was associated with 3.4-fold increased perinatal mortality. After stratifying by intrauterine growth restriction status, if infants were not intrauterine growth restricted, all types of PIH were not associated with increased perinatal mortality. However, when infants were intrauterine growth restricted, all types of PIH were associated with markedly increased perinatal mortality (e.g., 15-fold increased mortality for severe preeclampsia).


CONCLUSIONS
Intrauterine growth restriction secondary to PIH is associated with significantly increased perinatal mortality.
Xiong
Xu
X
Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, Tidewater Building, Suite 2022, SL-18, 1440 Canal Street, New Orleans, LA 70112, USA. xxiong@tulane.edu
Buekens
Pierre
P
Pridjian
Gabriella
G
Fraser
William D
WD
D000328:Adult; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000401:mortality* / Q000473:pathology; D007231:Infant, Newborn; D008428:Maternal Mortality; D008499:Medical Records; D011247:Pregnancy; D011256:Pregnancy Outcome; D012189:Retrospective Studies; D012720:Severity of Illness Index