Evaluation of hepatoprotective activity of Clerodendrum serratum L.
The ethanol extract of C. serratum roots and ursolic acid isolated from it were evaluated for hepatoprotective activity against carbon tetrachloride induced toxicity in male Wistar strain rats. The parameters studied were estimation of liver function serum markers such as serum total bilirubin, total protein, alanine transaminase, aspartate transaminase and alkaline phosphatase activities. The ursolic acid showed more significant hepatoprotective activity than crude extract. The histological profile of the liver tissue of the root extract and ursolic acid treated animal showed the presence of normal hepatic cords, absence of necrosis and fatty infiltration as similar to the controls. The results when compared with the standard drug silymarin, revealed that the hepatoprotective activity of the constituent ursolic acid is significant as similar to the standard drug.
Vidya
S M
SM
Department of Biotechnology, S.R.N.M.N. College of Applied Sciences, Shimoga 577 201, India.
Krishna
V
V
Manjunatha
B K
BK
Mankani
K L
KL
Ahmed
Manzoor
M
Singh
S D Jagadeesh
SD
D000818:Animals; D002251:Carbon Tetrachloride; D056486:Chemical and Drug Induced Liver Injury; D032409:Clerodendrum / Q000737:chemistry; D019610:Cytoprotection / Q000187:drug effects; D008099:Liver / Q000187:drug effects* / Q000473:pathology / Q000648:ultrastructure; D008107:Liver Diseases / Q000517:prevention & control*; D008297:Male; D008954:Models, Biological; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use*; D020011:Protective Agents / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D014315:Triterpenes / Q000302:isolation & purification / Q000494:pharmacology; D000097245:Ursolic Acid
D002251:Carbon Tetrachloride; D010936:Plant Extracts; D020011:Protective Agents; D014315:Triterpenes; D000097245:Ursolic Acid