title: Prophylaxis effect of Trigonella foenum graecum L. seeds on renal stone formation in rats.
abstract: Despite considerable progress in medical therapy, there is no satisfactory drug to treat kidney stones. Therefore, the current study aimed to look for an alternative by using Trigonella foenum graecum (Tfg) on nephrolithiasic rats as a preventive agent against the development of kidney stones, which is commonly used in Morocco as a phytotherapeutic agent. The inhibitory effect of the aqueous extract of Tfg seeds was examined on the formation of calcium oxalate renal stones induced by ethylene glycol (EG) with ammonium chloride. At the end of the experiment all kidneys were removed and examined microscopically for possible crystal/stone locations and the total calcium amount in the renal tissue was evaluated. The blood was recovered to determine the levels of calcium, phosphorus, creatinine and urea. The results showed that the amount of calcification in the kidneys and the total calcium amount of the renal tissue in rats treated with Tfg were significantly reduced compared with the untreated group. Consequently, Tfg may be a useful agent in the treatment of patients with calcic urolithiasis.
authors.affiliation: Laboratory of Animal Physiology Unit of Ecophysiology, Cadi-Ayyad University, Faculty of Science Semlalia Marrakech, Morocco. lar_amine@yahoo.fr
authors.forename: Amine
authors.initials: A
authors.lastname: Laroubi
authors.forename: Mohammed
authors.initials: M
authors.lastname: Touhami
authors.forename: Loubna
authors.initials: L
authors.lastname: Farouk
authors.forename: Ibtissam
authors.initials: I
authors.lastname: Zrara
authors.forename: Rachida
authors.initials: R
authors.lastname: Aboufatima
authors.forename: Ahmmed
authors.initials: A
authors.lastname: Benharref
authors.forename: Abderrahman
authors.initials: A
authors.lastname: Chait
mesh_terms: D000818:Animals; D002118:Calcium / Q000097:blood; D003404:Creatinine / Q000097:blood; D007669:Kidney Calculi / Q000473:pathology / Q000517:prevention & control*; D008297:Male; D010758:Phosphorus / Q000097:blood; D010936:Plant Extracts / Q000302:isolation & purification / Q000627:therapeutic use*; D020011:Protective Agents / Q000302:isolation & purification / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D012639:Seeds / Q000737:chemistry; D029910:Trigonella / Q000737:chemistry* / Q000196:embryology; D014508:Urea / Q000097:blood
chemical_list: D010936:Plant Extracts; D020011:Protective Agents; D010758:Phosphorus; D014508:Urea; D003404:Creatinine; D002118:Calcium