title: Synthesis and binding affinity of new pyrazole and isoxazole derivatives as potential atypical antipsychotics.
abstract: We describe the synthesis and binding affinities on D(2), 5-HT(2A) and 5-HT(2C) receptors of 6-aminomethyl-6,7-dihydro-1H-indazol-4(5H)-ones and 6-aminomethyl-6,7-dihydro-3-methyl-benzo[d]isoxazol-4(5H)-ones, as conformationally constrained butyrophenone analogues. One of the new compounds showed good in vitro binding features, and a Meltzer's ratio characteristic of an atypical antipsychotic profile.
authors.affiliation: Departamento de Química Orgánica, Laboratorio de Química Farmacéutica, Universidad de Santiago de Compostela, E-15782, Santiago de Compostela, Spain.
authors.forename: María
authors.initials: M
authors.lastname: Barceló
authors.forename: Enrique
authors.initials: E
authors.lastname: Raviña
authors.forename: Christian F
authors.initials: CF
authors.lastname: Masaguer
authors.forename: Eduardo
authors.initials: E
authors.lastname: Domínguez
authors.forename: Filipe Miguel
authors.initials: FM
authors.lastname: Areias
authors.forename: José
authors.initials: J
authors.lastname: Brea
authors.forename: María I
authors.initials: MI
authors.lastname: Loza
mesh_terms: D014150:Antipsychotic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002626:Chemistry, Pharmaceutical / Q000379:methods; D015195:Drug Design; D006801:Humans; D006860:Hydrogen Bonding; D007555:Isoxazoles / Q000138:chemical synthesis / Q000737:chemistry*; D007700:Kinetics; D008956:Models, Chemical; D008968:Molecular Conformation; D011485:Protein Binding; D011720:Pyrazoles / Q000138:chemical synthesis / Q000737:chemistry*; D044402:Receptor, Serotonin, 5-HT2A / Q000737:chemistry; D044405:Receptor, Serotonin, 5-HT2C / Q000737:chemistry; D017448:Receptors, Dopamine D2 / Q000737:chemistry; D012984:Software
chemical_list: D014150:Antipsychotic Agents; D007555:Isoxazoles; D011720:Pyrazoles; D044402:Receptor, Serotonin, 5-HT2A; D044405:Receptor, Serotonin, 5-HT2C; D017448:Receptors, Dopamine D2