title: Activities of respiratory chain complexes in isolated platelets in females with anorexia nervosa.
abstract: OBJECTIVE
  A broad spectrum of endocrine and biochemical disturbances was observed in patients with anorexia nervosa. In addition, metabolic changes may concern the efficiency of mitochondrial energy generating system. In our study we analyzed the activities of respiratory chain complexes in females with anorexia nervosa.
  
  
  METHODS
  The activities of respiratory chain complexes I, II, IV, I + III, and citrate synthase serving as the control enzyme were measured spectrophotometrically in isolated platelets in 36 females with anorexia nervosa (BMI 15 +/- 1.7) at the age 18-35 years and in 37 age related female controls (BMI 21 +/- 2.2).
  
  
  RESULTS
  In females with anorexia nervosa, the activities of respiratory chain complexes I and II in isolated platelets were significantly higher in comparison with controls. No differences were found in the activities of complexes IV and I + III and citrate synthase.
  
  
  CONCLUSIONS
  Our results suggest higher efficiency of some respiratory chain complexes in platelets in females with anorexia nervosa.
authors.affiliation: Centre of Applied Genomic, Department of Pediatrics, Faculty of Medicine, Charles University, Ke Karlovu 2, 128 08 Prague, Czech Republic.
authors.forename: Marek
authors.initials: M
authors.lastname: Böhm
authors.forename: Hana
authors.initials: H
authors.lastname: Papezova
authors.forename: Hana
authors.initials: H
authors.lastname: Hansikova
authors.forename: Laszlo
authors.initials: L
authors.lastname: Wenchich
authors.forename: Jiri
authors.initials: J
authors.lastname: Zeman
mesh_terms: D000293:Adolescent; D000328:Adult; D000856:Anorexia Nervosa / Q000097:blood*; D001792:Blood Platelets / Q000378:metabolism*; D016022:Case-Control Studies; D045222:Electron Transport Chain Complex Proteins / Q000097:blood*; D005260:Female; D006801:Humans
chemical_list: D045222:Electron Transport Chain Complex Proteins