Synthesis and biological evaluation of conformationally constrained analogues of the antitubercular agent ethambutol.
Three (S)-prolinol-derived conformationally restricted analogues of the antitubercular agent ethambutol were prepared and tested against Mycobacterium tuberculosis.
Faugeroux
Vanessa
V
Laboratoire de Synthèse et Physicochimie de Molécules d'Intérêt Biologique, UMR 5068, Université Paul Sabatier, 31062 Toulouse, Cedex 9, France.
Génisson
Yves
Y
Salma
Yahya
Y
Constant
Patricia
P
Baltas
Michel
M
D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015195:Drug Design; D004977:Ethambutol / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D007097:Imines / Q000737:chemistry; D008958:Models, Molecular; D008968:Molecular Conformation; D009169:Mycobacterium tuberculosis / Q000187:drug effects
D000995:Antitubercular Agents; D007097:Imines; D004977:Ethambutol