title: Salivary gland malignancy with divergent differentiation: is it a teratocarcinosarcoma?
abstract: Four poorly differentiated malignant lesions occurred in a 60-year-old Chinese male in the nasal cavity, submandibular gland, a lymph node in the neck, and the mandible. These malignant lesions developed within an 8-year period and each showed distinctive histological features. Among these malignant lesions, the neoplasm in the submandibular gland presented variegated histological and immunohistochemical (IHC) features and posed a diagnostic challenge in interpretation. Based on microscopic and IHC findings, we believe the diagnosis of teratocarcinosarcoma is justified for the submandibular neoplasm and the metastasis in the lymph node. The pathological features and diagnoses of these malignant lesions are discussed.
authors.affiliation: Department of Diagnostic Sciences, Baylor College of Dentistry, Texas A&M Health Science Center, Dallas, Texas, USA.
authors.forename: Yi-Shing Lisa
authors.initials: YS
authors.lastname: Cheng
authors.forename: Harvey
authors.initials: H
authors.lastname: Kessler
authors.forename: John
authors.initials: J
authors.lastname: Wright
authors.forename: Eric
authors.initials: E
authors.lastname: Huang
authors.forename: Ju-Ru
authors.initials: JR
authors.lastname: Lin
authors.forename: Li-Min
authors.initials: LM
authors.lastname: Lin
authors.forename: Yuk-Kwan
authors.initials: YK
authors.lastname: Chen
mesh_terms: D002296:Carcinosarcoma / Q000473:pathology* / Q000601:surgery; D006258:Head and Neck Neoplasms / Q000473:pathology / Q000556:secondary / Q000601:surgery; D006801:Humans; D008198:Lymph Nodes / Q000601:surgery; D008297:Male; D008339:Mandibular Neoplasms / Q000473:pathology* / Q000601:surgery; D008875:Middle Aged; D009296:Nasal Cavity / Q000473:pathology / Q000601:surgery; D009378:Neoplasms, Multiple Primary / Q000473:pathology* / Q000601:surgery; D009669:Nose Neoplasms / Q000473:pathology* / Q000601:surgery; D013365:Submandibular Gland Neoplasms / Q000473:pathology* / Q000601:surgery; D018243:Teratocarcinoma / Q000473:pathology* / Q000601:surgery