title: [Recovery from sevoflurane anesthesia delayed in hepatectomy patients due to influence of operation].
abstract: BACKGROUND
  We reported that recovery from total intravenous anesthesia with propofol was delayed in hepatectomy patients, and the hazard ratio was half against controls. This study was designed to evaluate recovery from sevoflurane anesthesia in patients for hepatectomy.
  
  
  METHODS
  Sixteen patients receiving hepatectomy and 17 patients receiving other epigastric surgeries (controls) were anesthetized with sevoflurane. Fentanyl was injected repeatedly to insure maintenance of the effect-site concentration of 2.0 ng x ml(-1). Propofol was administered for induction of general anesthesia, and then inhaled sevoflurane was titrated to maintain a Bispectral Index (BIS) value between 40 and 50. The intervals to emergence and extubation after sevoflurane discontinuation, and the predicted fentanyl concentrations were recorded.
  
  
  RESULTS
  The amount of sevoflurane and concentration of fentanyl in hepatectomy were similar to those in controls. The extubation time was longer in hepatectomy patients than in control subjects, and the hazard ratio was half against controls.
  
  
  CONCLUSIONS
  Recovery from anesthesia with sevoflurane was delayed in hepatectomy, and the hazard ratios were half against controls. We speculate that the influence of hepatectomy caused delay of recovery from anesthesia in hepatectomy patients.
authors.affiliation: Department of Anesthesiology, Tokyo Womens' Medical University, Tokyo 162-8666.
authors.forename: Fumiko
authors.initials: F
authors.lastname: Murata
authors.forename: Motoyo
authors.initials: M
authors.lastname: Iwade
authors.forename: Osamu
authors.initials: O
authors.lastname: Nagata
authors.forename: Makoto
authors.initials: M
authors.lastname: Ozaki
mesh_terms: D000762:Anesthesia Recovery Period; D000768:Anesthesia, General; D018685:Anesthetics, Inhalation / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005260:Female; D006498:Hepatectomy / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008738:Methyl Ethers / Q000008:administration & dosage / Q000493:pharmacokinetics*; D016016:Proportional Hazards Models; D000077149:Sevoflurane; D013997:Time Factors
chemical_list: D018685:Anesthetics, Inhalation; D008738:Methyl Ethers; D000077149:Sevoflurane