title: Association of AGTR1 with 18-month treatment outcome in late-life depression.
abstract: OBJECTIVE
  Converging lines of evidence implicate vascular factors in late-life depression, and argue that late-life depression is a distinct entity among the mood disorders. The A1166C polymorphism in the angiotensin II receptor, vascular type 1 (AGTR1) gene has been associated with a range of vascular diseases. This study investigated the association of AGTR1 genotype on 18-month treatment outcome in late-life depression.
  
  
  METHODS
  In a large, prospective cohort study, patients with late-life depression received individualized treatment using a standardized algorithm. The authors genotyped participants at the AGTR1 A1166C single nucleotide polymorphism (SNP) using standardized methodology, then used survival analysis to estimate the impact of A1166C and demographic variables on time to remission during 18 months of follow-up.
  
  
  RESULTS
  The hazard ratio for AGTR1 homozygous C/C status was 0.37. The A1166C SNP showed evidence for genotypic and allelic association in a comparison of remitted and unremitted/censored subjects.
  
  
  CONCLUSIONS
  Consistent with its association with numerous vascular disorders, AGTR1 is associated with treatment outcome in late-life depression. Further studies are needed to replicate this finding, and to investigate the impact of other genetic markers of vascular disease on late-life depression outcome.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA.
authors.forename: Douglas G
authors.initials: DG
authors.lastname: Kondo
authors.forename: Marcy C
authors.initials: MC
authors.lastname: Speer
authors.forename: K Ranga
authors.initials: KR
authors.lastname: Krishnan
authors.forename: Douglas R
authors.initials: DR
authors.lastname: McQuoid
authors.forename: Susan H
authors.initials: SH
authors.lastname: Slifer
authors.forename: Carl F
authors.initials: CF
authors.lastname: Pieper
authors.forename: Ashley V
authors.initials: AV
authors.lastname: Billups
authors.forename: David C
authors.initials: DC
authors.lastname: Steffens
mesh_terms: D017668:Age of Onset; D000368:Aged; D000465:Algorithms; D000075244:Apelin Receptors; D015331:Cohort Studies; D003710:Demography; D003865:Major Depressive Disorder / Q000188:drug therapy* / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D011446:Prospective Studies; D011945:Receptors, Angiotensin / Q000235:genetics; D043562:Receptors, G-Protein-Coupled / Q000235:genetics*; D013997:Time Factors
chemical_list: C104575:APLNR protein, human; D000075244:Apelin Receptors; D011945:Receptors, Angiotensin; D043562:Receptors, G-Protein-Coupled