title: [Effect of cyclovirobuxinum-D on cerebral ischemia-reperfusion injury in rats].
abstract: OBJECTIVE
  To observe the effect of cyclovirobuxinum-D (CVB-D) on cerebral ischemia-reperfusion injury in rats and explore its mechanisms.
  
  
  METHODS
  One hundred and twenty rats were randomly divided into three CVB-D groups (2, 1, 0.5 mg x kg(-1)), Nimodipine group (2 mg x kg(-1)), model group and sham operated group, 20 rats each group. Rat cerebral ischemia-reperfusion injury model was induced by middle cerebral artery occlusion, the nerve injury symptoms was evaluated, the level of SOD and MDA in brain tissue were determined, the concentration of intracellar Ca2+ of brain was measured, and the pathological change of brain was also observed.
  
  
  RESULTS
  CVB-D could improve the nerve injury symptoms, reduce the infarction area of brain, the concentration of intracellar Ca2+ and the level of MDA, increase the activity of SOD, and decrease the pathological change of brain.
  
  
  CONCLUSIONS
  CVB-D has protective effect on cerebral ischemia-reperfusion injury in rats.
authors.affiliation: Anhui Science and Technology University, Bengbu 233100, China. yuchengzi1230@163.com
authors.forename: Hao
authors.initials: H
authors.lastname: Yu
authors.forename: Han-Zhen
authors.initials: HZ
authors.lastname: Liu
authors.forename: Guo-Liang
authors.initials: GL
authors.lastname: Zhou
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D031235:Buxus / Q000737:chemistry; D002118:Calcium / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D020244:Infarction, Middle Cerebral Artery / Q000150:complications; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D018696:Neuroprotective Agents / Q000302:isolation & purification / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D015427:Reperfusion Injury / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control*; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D004365:Drugs, Chinese Herbal; D018696:Neuroprotective Agents; C524545:cyclovirobuxinum D; D008315:Malondialdehyde; D013482:Superoxide Dismutase; D002118:Calcium