Efficient method for the synthesis of polysubstituted benzenes by one-pot tandem reaction of vinyl malononitriles with nitroolefins.
The one-pot synthesis of polysubstituted benzene derivatives was achieved via vinylogous Michael addition of vinyl malononitriles and nitroolefins as the key step and a sequential tandem reaction. A series of complex aryl compounds such as biphenyls and terphenyls can be obtained with satisfactory yields.
Xue
Dong
D
Key Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, School of Chemistry and Materials Science, Shaanxi Normal University, Xi'an, 710062, People's Republic of China. xuedong_welcome@snnu.edu.cn
Li
Jie
J
Zhang
Zun-Ting
ZT
Deng
Jin-Gen
JG
D000475:Alkenes / Q000737:chemistry*; D001554:Benzene / Q000138:chemical synthesis / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry*; D009574:Nitro Compounds / Q000737:chemistry*; D014753:Vinyl Compounds / Q000737:chemistry*
D000475:Alkenes; D007659:Ketones; D009570:Nitriles; D009574:Nitro Compounds; D014753:Vinyl Compounds; C000945:dicyanmethane; D001554:Benzene