title: Silylation of triacylglycerol: an easy route to new biosiloxanes.
abstract: A new approach to functionalize triacylglycerol fish oils has been achieved. For the first time, hydrosilylation of various terminal and internal C=C double bonds in ethylenic triacylglycerol was performed under radical initiation sequence, which, after ethanolysis, gave the sol-gel processable triethoxysilyltriacylglycerol P(2). By the use of silyltriflate, new metalated triglycerides P(3), in which silyl fragments are C-bonded in alpha-position to glycerol groups, were synthesized. The sol-gel hydrolysis and polycondensation of triethoxysilyltriacylglycerol led to hybrid materials in which organic and inorganic moieties are covalently linked. These materials open new applications in drug delivery and pharmaceutical formulation.
authors.affiliation: Laboratoire d'Hétérochimie Fondamentale et Appliquée, UMR 5069, Université Paul Sabatier, 118 Route de Narbonne, 31062 Toulouse Cedex 9, France.
authors.forename: Abdelkrim
authors.initials: A
authors.lastname: El Kadib
authors.forename: Annie
authors.initials: A
authors.lastname: Castel
authors.forename: Fabien
authors.initials: F
authors.lastname: Delpech
authors.forename: Pierre
authors.initials: P
authors.lastname: Rivière
mesh_terms: D016503:Drug Delivery Systems / Q000379:methods*; D000431:Ethanol / Q000737:chemistry; D005395:Fish Oils / Q000737:chemistry; D005782:Gels / Q000737:chemistry; D006868:Hydrolysis; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D012821:Silanes / Q000737:chemistry*; D012833:Siloxanes / Q000138:chemical synthesis*; D012995:Solubility; D014280:Triglycerides / Q000737:chemistry*
chemical_list: D005395:Fish Oils; D005782:Gels; D004364:Pharmaceutical Preparations; D012821:Silanes; D012833:Siloxanes; D014280:Triglycerides; D000431:Ethanol