title: Hyperbaric oxygen therapy for interstitial cystitis resistant to conventional treatments.
abstract: We treated two cases of interstitial cystitis (IC) that were resistant to some conventional therapies with hyperbaric oxygen (HBO). Both patients underwent 20 sessions of 100% oxygen inhalation (2.0 atmosphere absolute for 60 min/day x 5 days/week for 4 weeks) in a hyperbaric chamber. The period of follow up was 12 months for case 1 and 9 months for case 2. After a course of HBO, the bladder mucosal ulcer (Hunner's ulcer) disappeared, and changes from baseline in pain and urinary frequency was constitutively inhibited. There were no adverse events during the 20 treatment sessions. One woman (case 1) had mild Eustachian tube dysfunction, resulting in a transient hearing impairment. HBO seems to be an option for treatment of IC resistant to conventional therapies.
authors.affiliation: Department of Urology, Osaka City University Graduate School of Medicine, Osaka, Japan. tomoaki826@msic.med.osaka-cu.ac.jp
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Tanaka
authors.forename: Hidenori
authors.initials: H
authors.lastname: Kawashima
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Makino
authors.forename: Sadanori
authors.initials: S
authors.lastname: Kamikawa
authors.forename: Noboru
authors.initials: N
authors.lastname: Kato
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Nakatani
mesh_terms: D000368:Aged; D018856:Cystitis, Interstitial / Q000473:pathology / Q000628:therapy*; D003558:Cystoscopy; D005260:Female; D006801:Humans; D006931:Hyperbaric Oxygenation / Q000009:adverse effects / Q000379:methods*; D008875:Middle Aged; D010146:Pain / Q000473:pathology; D059408:Pain Management; D010147:Pain Measurement; D014456:Ulcer / Q000473:pathology / Q000628:therapy*; D014554:Urination