title: Maculopathy in uveitis of juvenile idiopathic arthritis: an optical coherence tomography study.
abstract: OBJECTIVE
  The aim of this study was to examine the frequency and characteristics of macular lesions observed in juvenile idiopathic arthritis (JIA) uveitis, using optical coherence tomography (OCT).
  
  
  METHODS
  In this cross-sectional study, 38 consecutive patients were recruited from a tertiary referral center in uveitis. All eyes with JIA uveitis underwent complete ophthalmic examination including OCT 3. Exclusion criterion was the inability to obtain OCT scans. Flare and visual acuity were also analysed by using linear regression.
  
  
  RESULTS
  We analysed foveal thickness (FT) and central foveal thickness (CFT), using software mapping, to describe macular lesions in 61 eyes. Maculopathy was observed in 51 eyes (84%) compared with 12% in the literature (p<0.0001) and comprised four types: perifoveolar thickening in 45 eyes (74%), macular oedema in 29 eyes (48%), foveal detachment in 11 eyes (18%) and atrophic changes in six eyes (10%). Only four eyes did not demonstrate any lesion.
  
  
  CONCLUSIONS
  Among children with JIA uveitis, macular involvement is frequent and characterised by perifoveolar thickening and serous retinal detachment. OCT is a non-invasive instrument. It can easily identify this maculopathy, which could impair visual function, and require therapeutic intensification.
authors.affiliation: Department of Ophthalmology, Pitié-Salpêtrière Hospital, 47 bd de l'Hôpital, Paris, France.
authors.forename: G
authors.initials: G
authors.lastname: Ducos de Lahitte
authors.forename: C
authors.initials: C
authors.lastname: Terrada
authors.forename: T H C
authors.initials: TH
authors.lastname: Tran
authors.forename: N
authors.initials: N
authors.lastname: Cassoux
authors.forename: P
authors.initials: P
authors.lastname: LeHoang
authors.forename: L
authors.initials: L
authors.lastname: Kodjikian
authors.forename: B
authors.initials: B
authors.lastname: Bodaghi
mesh_terms: D000293:Adolescent; D000328:Adult; D018501:Antirheumatic Agents / Q000627:therapeutic use; D001171:Arthritis, Juvenile / Q000150:complications* / Q000188:drug therapy; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D005260:Female; D005584:Fovea Centralis / Q000473:pathology; D006801:Humans; D008266:Macula Lutea / Q000473:pathology*; D008269:Macular Edema / Q000175:diagnosis / Q000209:etiology; D008297:Male; D008875:Middle Aged; D012163:Retinal Detachment / Q000175:diagnosis / Q000209:etiology; D012164:Retinal Diseases / Q000175:diagnosis / Q000209:etiology*; D041623:Tomography, Optical Coherence; D014605:Uveitis / Q000209:etiology*
chemical_list: D018501:Antirheumatic Agents