All roads lead to IKKepsilon.
Extensive genetic alterations have been found in many epithelial malignancies. Using three complementary genetic approaches, Boehm et al. (2007) identify IKBKE--which encodes IKKepsilon, a component of the NF-kappaB pathway--as a breast cancer oncogene.
Agami
Reuven
R
Division of Tumor Biology, The Netherlands Cancer Institute, Amsterdam 1066 CX, The Netherlands. r.agami@nki.nl
D001943:Breast Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000628:therapy; D045744:Cell Line, Tumor; D002471:Cell Transformation, Neoplastic; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D051550:I-kappa B Kinase / Q000502:physiology*; D016328:NF-kappa B / Q000378:metabolism*; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D015398:Signal Transduction
D016328:NF-kappa B; D019869:Phosphatidylinositol 3-Kinases; D051550:I-kappa B Kinase