Large-scale surveillance of Plasmodium falciparum crt(K76T) in northern Ghana.
Surveillance of Plasmodium falciparum crt(K76T) [Pfcrt(K76T)], a resistance marker of chloroquine and, limitedly, amodiaquine, in >4,000 children in northern Ghana revealed a prevalence of 79%. Pfcrt(K76T) was heterogeneously distributed and associated with chloroquine use, low parasitemia, and the dry season. Widespread chloroquine resistance challenges the regional life span of amodiaquine as a partner drug in artemisinin combination therapy.
Ehrhardt
Stephan
S
Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Strasse 74, 20359 Hamburg, Germany. ehrhardt@bni-hamburg.de
Eggelte
Teunis A
TA
Kaiser
Sarah
S
Adjei
Lydia
L
Burchard
Gerd D
GD
Anemana
Sylvester D
SD
Bienzle
Ulrich
U
Mockenhaupt
Frank P
FP
D000293:Adolescent; D000328:Adult; D000368:Aged; D000655:Amodiaquine / Q000494:pharmacology; D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D037621:Artemisinins / Q000627:therapeutic use; D002648:Child; D002738:Chloroquine / Q000494:pharmacology; D004351:Drug Resistance / Q000235:genetics*; D004359:Drug Therapy, Combination; D005260:Female; D017125:Genes, Protozoan / Q000235:genetics*; D005838:Genotype; D005869:Ghana / Q000453:epidemiology; D006801:Humans; D007783:Lactones / Q000627:therapeutic use; D016778:Malaria, Falciparum / Q000453:epidemiology* / Q000469:parasitology*; D008297:Male; D008875:Middle Aged; D018512:Parasitemia / Q000469:parasitology; D010963:Plasmodium falciparum / Q000235:genetics*; D011159:Population Surveillance; D012717:Sesquiterpenes / Q000627:therapeutic use
D000962:Antimalarials; D037621:Artemisinins; D007783:Lactones; D012717:Sesquiterpenes; D000655:Amodiaquine; D002738:Chloroquine; C075875:artemisin