Endophthalmitis due to Trichosporon beigelii in acute leukemia.
We describe 2 patients with hematologic malignancy who developed endophthalmitis due to Trichosporon beigelii during the course of treatment with multiagent chemotherapy. Blood cultures revealed T beigelii for both patients. Although one of the patients was treated with fluconazole (FLCZ) and 5-fluorocytosine, the trichosporonous endophthalmitis was resistant to both drugs. This patient subsequently received amphotericin B (AMPH-B) therapy, and the eyes were treated with vitrectomy. The second patient also received AMPH-B for FLCZ-resistant trichosporonous chorioretinitis. In both patients, systemic treatment with AMPH-B successfully resolved the trichosporonous endophthalmitis that was resistant to multiple antifungal drugs. Endophthalmitis due to trichosporonosis is difficult to treat. The administration of AMPH-B is likely to be more effective in treating endophthalmitis due to trichosporonosis when the disease is at an early stage.
Hara
Satoshi
S
Department of Internal Medicine (I), Osaka Medical College, Osaka, Japan. in1211@poh.osaka-med.ac.jp
Yokote
Taiji
T
Oka
Satoko
S
Akioka
Toshikazu
T
Kobayashi
Kichinosuke
K
Hirata
Yuji
Y
Miyoshi
Takuji
T
Tsuji
Motomu
M
Hanafusa
Toshiaki
T
D000208:Acute Disease; D000328:Adult; D000666:Amphotericin B / Q000008:administration & dosage; D000935:Antifungal Agents / Q000008:administration & dosage; D025141:Drug Resistance, Fungal; D009877:Endophthalmitis / Q000150:complications* / Q000188:drug therapy / Q000382:microbiology*; D005260:Female; D015725:Fluconazole / Q000008:administration & dosage; D005437:Flucytosine / Q000008:administration & dosage; D006801:Humans; D007951:Leukemia, Myeloid / Q000150:complications* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D009181:Mycoses / Q000150:complications* / Q000188:drug therapy; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000188:drug therapy; D014250:Trichosporon
D000935:Antifungal Agents; D000666:Amphotericin B; D015725:Fluconazole; D005437:Flucytosine