title: Ten years after the first Helicobacter pylori genome: comparative and functional genomics provide new insights in the variability and adaptability of a persistent pathogen.
abstract: In this review, we summarize how genomic approaches contributed to the understanding of the biology of the recently discovered pathogen Helicobacter pylori. Comparative genomics provided new insights into H. pylori's spectacular genetic diversity and generated exiting hypotheses on its evolutionary history. Transcriptomic studies provided original information on the mechanisms of H. pylori gastric adaptation that are central to its virulence.
authors.affiliation: Institut Pasteur, Unité de Pathogénie Bacterienne des Muqueuses, Paris, France.
authors.forename: Hilde
authors.initials: H
authors.lastname: de Reuse
authors.forename: Stefan
authors.initials: S
authors.lastname: Bereswill
mesh_terms: D000222:Adaptation, Physiological / Q000235:genetics*; D014644:Genetic Variation; D016680:Genome, Bacterial / Q000235:genetics*; D023281:Genomics / Q000379:methods; D016480:Helicobacter pylori / Q000235:genetics* / Q000472:pathogenicity; D014774:Virulence / Q000235:genetics