title: Medullary thyroid cancer treated by capecitabine.
abstract: Medullary thyroid carcinoma with distant metastases is generally incurable, with 20% overall survival at 10 years. The treatment goal is palliative. Chemotherapy has a limited role, with low response rates and high toxicities with the different regimens. Here, we report the case of 64-year-old man with metastatic medullary thyroid carcinoma in progression after primary treatment with cisplatin-doxorubicin. The patient received capecitabine 2000 mg/m total per day x 14 days followed by 1-week rest. He received 41 cycles, and presented prolonged and objective tumor response (30 months), without any toxicity.
authors.affiliation: Department of Medical Oncology, Institut Paoli Calmettes, 232 Boulevard Sainte Marguerite, 13009 Marseille, France. labidi@lyon.fnclcc.fr
authors.forename: Sana Intidhar
authors.initials: SI
authors.lastname: Labidi
authors.forename: Gwenaelle
authors.initials: G
authors.lastname: Gravis
authors.forename: Carole
authors.initials: C
authors.lastname: Tarpin
authors.forename: Vincent
authors.initials: V
authors.lastname: Brun
authors.forename: Patrice
authors.initials: P
authors.lastname: Viens
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000627:therapeutic use; D000069287:Capecitabine; D018276:Carcinoma, Medullary / Q000188:drug therapy*; D002945:Cisplatin / Q000627:therapeutic use; D003841:Deoxycytidine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004317:Doxorubicin / Q000627:therapeutic use; D005472:Fluorouracil / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D010166:Palliative Care; D013964:Thyroid Neoplasms / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D000964:Antimetabolites, Antineoplastic; D000970:Antineoplastic Agents; D003841:Deoxycytidine; D000069287:Capecitabine; D004317:Doxorubicin; D002945:Cisplatin; D005472:Fluorouracil