Shape deformity of the corpus striatum in obsessive-compulsive disorder.
Volumetric changes of striatal structures based on magnetic resonance imaging (MRI) have been inconsistent in patients with obsessive-compulsive disorder (OCD) due to methodological limitations. The purpose of this study was to investigate shape deformities of the corpus striatum in patients with OCD. We performed 3-D shape deformation analysis of the caudate nucleus, the putamen, and the globus pallidus in 36 patients with OCD and 36 healthy normal subjects. Shape analysis showed deformity of the striatal structures, especially the caudate nucleus. Outward deformities in the superior, anterior portion of the bilateral caudate were observed in patients with OCD. In addition, an outward deformity in the inferior, lateral portion of the left putamen was also detected. These results suggest that patients with OCD have shape deformities of the corpus striatum, especially the caudate nucleus, compared with healthy normal subjects, and that shape analysis may provide an important complement to volumetric MRI studies in investigating the pathophysiology of OCD.
Choi
Jung-Seok
JS
Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea.
Kim
Sun Hyung
SH
Yoo
So Young
SY
Kang
Do-Hyung
DH
Kim
Chi-Won
CW
Lee
Jong-Min
JM
Kim
In Young
IY
Kim
Sun I
SI
Kim
Young Youn
YY
Kwon
Jun Soo
JS
D000328:Adult; D002421:Caudate Nucleus / Q000002:abnormalities / Q000503:physiopathology; D003342:Corpus Striatum / Q000002:abnormalities* / Q000503:physiopathology*; D005260:Female; D005917:Globus Pallidus / Q000002:abnormalities / Q000503:physiopathology; D006801:Humans; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging; D008297:Male; D008959:Models, Neurological; D009415:Nerve Net / Q000503:physiopathology; D009771:Obsessive-Compulsive Disorder / Q000175:diagnosis* / Q000503:physiopathology*; D011699:Putamen / Q000002:abnormalities / Q000503:physiopathology