title: New triterpene glucosides, oligoporins A-C, from Oligoporus tephroleucus protect DNA from Fenton reaction.
abstract: New triterpene glucosides, oligoporins A (1), B (2), and C (3), were isolated from the methanolic extract of the fruiting bodies of Oligoporus tephroleucus (Polyporaceae). Their structures were established by spectroscopic methods. These compounds significantly exhibited protective effect to plasmid DNA damage by hydroxyl radical (*OH) generated from the Fenton reaction with hydrogen peroxide and ferrous.
authors.affiliation: Functional Metabolomics Research Center, KRIBB, Yuseong, Daejeon, Republic of Korea.
authors.forename: In-Kyoung
authors.initials: IK
authors.lastname: Lee
authors.forename: Yun-Woo
authors.initials: YW
authors.lastname: Jang
authors.forename: Seung Hun
authors.initials: SH
authors.lastname: Yu
authors.forename: Bong-Sik
authors.initials: BS
authors.lastname: Yun
mesh_terms: D000818:Animals; D001487:Basidiomycota / Q000378:metabolism*; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D004247:DNA / Q000737:chemistry*; D004249:DNA Damage; D053938:DNA Fragmentation; D015195:Drug Design; D005960:Glucosides / Q000737:chemistry* / Q000494:pharmacology; D006861:Hydrogen Peroxide / Q000737:chemistry / Q000494:pharmacology; D017665:Hydroxyl Radical; D007501:Iron / Q000737:chemistry / Q000494:pharmacology; D008956:Models, Chemical; D013053:Spectrophotometry / Q000379:methods; D014315:Triterpenes / Q000737:chemistry* / Q000494:pharmacology
chemical_list: C045076:Fenton's reagent; D005960:Glucosides; D014315:Triterpenes; C524216:oligoporin A; C524217:oligoporin B; C524218:oligoporin C; D017665:Hydroxyl Radical; D004247:DNA; D006861:Hydrogen Peroxide; D007501:Iron