title: Amyotrophic lateral sclerosis with sensory neuropathy: part of a multisystem disorder?
abstract: Sensory involvement is thought not to be a feature of amyotrophic lateral sclerosis (ALS). However, in the setting of a specialist motor neuron disease clinic, we have identified five patients with sporadic ALS and a sensory neuropathy for which an alternative cause could not be identified. In three individuals, sensory nerve biopsy was performed, demonstrating axonal loss without features of an alternative aetiology. These findings support the hypothesis that ALS is a multisystem neurodegenerative disorder that may occasionally include sensory neuropathy among its non-motor features.
authors.affiliation: King's College London MRC Centre for Neurodegeneration Research, Department of Neurology, Institute of Psychiatry, London, UK.
authors.forename: Jeremy D
authors.initials: JD
authors.lastname: Isaacs
authors.forename: Andrew F
authors.initials: AF
authors.lastname: Dean
authors.forename: Christopher E
authors.initials: CE
authors.lastname: Shaw
authors.forename: Ammar
authors.initials: A
authors.lastname: Al-Chalabi
authors.forename: Kerry R
authors.initials: KR
authors.lastname: Mills
authors.forename: P Nigel
authors.initials: PN
authors.lastname: Leigh
mesh_terms: D000200:Action Potentials; D000368:Aged; D000690:Amyotrophic Lateral Sclerosis / Q000150:complications* / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009475:Neurons, Afferent / Q000473:pathology; D012678:Sensation Disorders / Q000209:etiology*