Specific binding of [3H]Ro 19-6327 (lazabemide) to monoamine oxidase B is increased in frontal cortex of suicide victims after controlling for age at death.
Previous studies have reported negative findings for the association among brain monoamine oxidase B (MAO-B) and suicidal behaviour. However those studies did not adequately control their main results for the influence of confounding variables such as age at death. We have evaluated the association of MAO-B density (assessed by [3H]Ro 19-6327 - lazabemide - binding) with type of death (suicide victims vs non-suicide controls) after controlling for age at death. Frontal cortex samples from 43 subjects (21 suicides, 22 controls) were assayed for MAO-B density at a single concentration of lazabemide (8 nM). A linear regression modelling approach comparing nested models resulted with both type of death (p<0.05) and age of death (p<0.01) as main explanatory variables for the variability of MAO-B density. Suicide victims had >30% more binding sites for lazabemide than controls. Contrary to previous reports, MAO-B density seems to increase in suicide victims.
Ballesteros
Javier
J
University of the Basque Country, Department of Neuroscience, Barrio Sarriena s/n, 48940-Leioa, Spain. javier.ballesteros@ehu.es <javier.ballesteros@ehu.es>
Maeztu
Ana I
AI
Callado
Luis F
LF
Meana
J Javier
JJ
Gutiérrez
Miguel
M
D000328:Adult; D000375:Aging; D000437:Alcoholism / Q000150:complications / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical; D008995:Monoamine Oxidase / Q000378:metabolism*; D010848:Picolinic Acids / Q000378:metabolism*; D017397:Prefrontal Cortex / Q000201:enzymology / Q000378:metabolism*; D011485:Protein Binding; D011619:Psychotropic Drugs / Q000097:blood; D012044:Regression Analysis; D013405:Suicide
D010848:Picolinic Acids; D011619:Psychotropic Drugs; C059303:lazabemide; D008995:Monoamine Oxidase