Use of 5-aminolevulinic acid in fluorescence-guided resection of meningioma with high risk of recurrence. Case report.
It has been established that fluorescence-guided resection using 5-aminolevulinic acid (5-ALA) is useful in glioma surgery. The authors report on a 65-year-old woman who had a huge atypical left-hemisphere meningioma, which extended into the skull and to the superior sagittal sinus and demonstrated fluorescence in response to administration of 5-ALA. After the tumor was removed, the operative field was observed under the fluorescent mode of a fluorescence surgical microscopy system. Several minute areas of residual tumor tissue were visualized as strong fluorescence behind the vein and sinus, in a part of the hypertrophic dura, and along the edge of the skull. These remnants were completely removed. The authors concluded that fluorescence-guided resection using 5-ALA is useful in cases of atypical meningiomas with a high risk of recurrence.
Kajimoto
Yoshinaga
Y
Departments of'Neurosurgery, Osaka Medical College, Osaka, Japan. neu039@poh.osaka-med.ac.jp
Kuroiwa
Toshihiko
T
Miyatake
Shin-Ichi
S
Ichioka
Tsugumichi
T
Miyashita
Minoru
M
Tanaka
Hidekazu
H
Tsuji
Motomu
M
D000368:Aged; D000622:Aminolevulinic Acid; D003399:Craniotomy; D005260:Female; D005453:Fluorescence; D006801:Humans; D008279:Magnetic Resonance Imaging; D008579:Meningioma / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery*; D008856:Microscopy, Fluorescence; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local; D019635:Neurosurgical Procedures
D000622:Aminolevulinic Acid