Evolutionary dynamics of immune-related genes and pathways in disease-vector mosquitoes.
Mosquitoes are vectors of parasitic and viral diseases of immense importance for public health. The acquisition of the genome sequence of the yellow fever and Dengue vector, Aedes aegypti (Aa), has enabled a comparative phylogenomic analysis of the insect immune repertoire: in Aa, the malaria vector Anopheles gambiae (Ag), and the fruit fly Drosophila melanogaster (Dm). Analysis of immune signaling pathways and response modules reveals both conservative and rapidly evolving features associated with different functional gene categories and particular aspects of immune reactions. These dynamics reflect in part continuous readjustment between accommodation and rejection of pathogens and suggest how innate immunity may have evolved.
Waterhouse
Robert M
RM
Division of Cell and Molecular Biology, Faculty of Natural Sciences, Imperial College London, London SW7 2AZ, UK.
Kriventseva
Evgenia V
EV
Meister
Stephan
S
Xi
Zhiyong
Z
Alvarez
Kanwal S
KS
Bartholomay
Lyric C
LC
Barillas-Mury
Carolina
C
Bian
Guowu
G
Blandin
Stephanie
S
Christensen
Bruce M
BM
Dong
Yuemei
Y
Jiang
Haobo
H
Kanost
Michael R
MR
Koutsos
Anastasios C
AC
Levashina
Elena A
EA
Li
Jianyong
J
Ligoxygakis
Petros
P
Maccallum
Robert M
RM
Mayhew
George F
GF
Mendes
Antonio
A
Michel
Kristin
K
Osta
Mike A
MA
Paskewitz
Susan
S
Shin
Sang Woon
SW
Vlachou
Dina
D
Wang
Lihui
L
Wei
Weiqi
W
Zheng
Liangbiao
L
Zou
Zhen
Z
Severson
David W
DW
Raikhel
Alexander S
AS
Kafatos
Fotis C
FC
Dimopoulos
George
G
Zdobnov
Evgeny M
EM
Christophides
George K
GK
D000330:Aedes / Q000235:genetics* / Q000276:immunology; D000818:Animals; D000852:Anopheles / Q000235:genetics* / Q000276:immunology; D023181:Antimicrobial Cationic Peptides / Q000502:physiology; D002352:Carrier Proteins / Q000235:genetics / Q000502:physiology; D004331:Drosophila melanogaster / Q000235:genetics / Q000276:immunology; D019143:Evolution, Molecular; D017344:Genes, Insect; D007113:Immunity, Innate / Q000235:genetics*; D019476:Insect Proteins / Q000235:genetics / Q000502:physiology; D007303:Insect Vectors / Q000235:genetics* / Q000276:immunology; D008288:Malaria / Q000635:transmission; D008543:Melanins / Q000378:metabolism; D005810:Multigene Family; D015398:Signal Transduction; D013045:Species Specificity
D023181:Antimicrobial Cationic Peptides; D002352:Carrier Proteins; D019476:Insect Proteins; D008543:Melanins; C118897:peptidoglycan recognition protein