title: Acute oral toxicity study of Asiasari radix extract in mice.
abstract: Acute oral toxicity of methanol extract of Asiasari radix was evaluated in ICR mice of both sexes. In this study, mice were administrated orally with dosages of 1000, 3000, and 5000 mg/kg body weight of Asiasari radix extract. Mortality, signs of toxicity, body weight, food consumption, and gross findings were observed for 14 days post treatment of Asiasari radix extract. No mortality, signs of toxicity, and abnormalities in gross findings were observed. In addition, no significant differences were noticed in the body and organ weights between the control and treated groups of both sexes. These results show that the methanol extract of Asiasari radix is toxicologically safe by oral administration.
authors.affiliation: Department of Pharmacology, School of Dentistry, Kyung Hee University, Seoul, South Korea.
authors.forename: T
authors.initials: T
authors.lastname: Ramesh
authors.forename: K
authors.initials: K
authors.lastname: Lee
authors.forename: H W
authors.initials: HW
authors.lastname: Lee
authors.forename: S J
authors.initials: SJ
authors.lastname: Kim
mesh_terms: D000284:Administration, Oral; D000818:Animals; D029065:Aristolochiaceae / Q000737:chemistry / Q000633:toxicity; D001835:Body Weight / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000633:toxicity*; D005260:Female; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009929:Organ Size / Q000187:drug effects; D023382:Toxicity Tests, Acute
chemical_list: D004365:Drugs, Chinese Herbal