The glutathione thiyl radical does not react with nitrogen monoxide.
Laser flash photolysis experiments shows that the rate constant for the reaction of the glutathione thiyl radical with nitrogen monoxide to give S-nitrosoglutathione is lower than 2.8+/-0.6 x 10(7)M(-1)s(-1). The conversion of the thiyl radical to its carbon-centred form at 10(3)s(-1) exceeds the formation of S-nitrosoglutathione when physiological concentrations of nitrogen monoxide are taken into account.
Hofstetter
Dustin
D
Laboratory for Inorganic Chemistry, Department of Chemistry and Applied Bioscience, ETH Zurich, Wolfgang-Pauli-Strasse 10, CH-8093 Zurich, Switzerland.
Nauser
Thomas
T
Koppenol
Willem H
WH
D005609:Free Radicals / Q000737:chemistry; D005978:Glutathione / Q000737:chemistry*; D009569:Nitric Oxide / Q000737:chemistry*; D013438:Sulfhydryl Compounds / Q000737:chemistry*
D005609:Free Radicals; D013438:Sulfhydryl Compounds; D009569:Nitric Oxide; D005978:Glutathione