title: Allosteric enhancers for A1 adenosine receptor.
abstract: Allosteric enhancers at the adenosine A(1) receptor have received attention as anti-arrhythmic cardiac agents, and, more recently, as anti-lipolytic agents. In addition, allosteric modulators at the adenosine A(1) receptor have therapeutic potential as analgesics and neuroprotective agents. In particular, the compounds with improved potency as enhancers and reduced antagonist properties are mentioned.
authors.affiliation: Dipartimento di Scienze Farmaceutiche, Università di Ferrara, Ferrara, Italy. baraldi@unife.it
authors.forename: Pier Giovanni
authors.initials: PG
authors.lastname: Baraldi
authors.forename: Maria Antonietta
authors.initials: MA
authors.lastname: Iaconinoto
authors.forename: Allan R
authors.initials: AR
authors.lastname: Moorman
authors.forename: Maria Dora
authors.initials: MD
authors.lastname: Carrion
authors.forename: Carlota Lopez
authors.initials: CL
authors.lastname: Cara
authors.forename: Delia
authors.initials: D
authors.lastname: Preti
authors.forename: Olga Cruz
authors.initials: OC
authors.lastname: López
authors.forename: Francesca
authors.initials: F
authors.lastname: Fruttarolo
authors.forename: Mojgan Aghazade
authors.initials: MA
authors.lastname: Tabrizi
authors.forename: Romeo
authors.initials: R
authors.lastname: Romagnoli
mesh_terms: D058907:Adenosine A1 Receptor Agonists; D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism; D006801:Humans; D008968:Molecular Conformation; D043682:Receptor, Adenosine A1 / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D058907:Adenosine A1 Receptor Agonists; D043682:Receptor, Adenosine A1; D000242:Cyclic AMP