title: Cognitive slowing in cognitive-motor disorder associated to type 1 human immunodeficiency virus: TR and P300.
abstract: BACKGROUND
  Reaction time (RT) deficit exhibited by HIV-1 asymptomatic seropositive individuals cannot always be explained by the effect of a cognitive slowing single factor. Evidence exists that decisional and peripheral components of RT may have differential slowing.
  
  
  OBJECTIVE
  To assess the hypothesis of a cognitive slowing single factor as the main responsible for RT slowing in these subjects.
  
  
  METHODS
  Thirty two (32) HIV-1 neurologically asymptomatic seropositive individuals were compared to 29 seronegative controls in two discriminative reaction time tasks (DRT) having increased cognitive difficulty but equal motor response demands. P300 component of the event-related potential was recorded simultaneously. RT, PPI, errors, and P300 latency were assessed using ANOVA.
  
  
  RESULTS
  Seropositives were slower than controls in RT, made more errors and showed delayed latencies of P300 in both tasks. However, while the increase of RT from the easier to the more difficult task was additive, the increase of P300 latencies was multiplicative.
  
  
  CONCLUSIONS
  These results reveal differences in patterns of slowing between central and motor information processing mechanisms. Such results suggest that a single common factor is not enough to explain cognitive slowing in HIV-1 seropositive subjects.
authors.affiliation: Instituto Nacional de Salud de los Trabajadores, Ciudad de La Habana, Cuba. felixz@infomed.sld.cu
authors.forename: F
authors.initials: F
authors.lastname: Amador Romero
authors.forename: M
authors.initials: M
authors.lastname: Pelegrina del Rio
authors.forename: J
authors.initials: J
authors.lastname: Mayor Ríos
mesh_terms: D015526:AIDS Dementia Complex / Q000175:diagnosis* / Q000821:virology*; D000328:Adult; D004569:Electroencephalography; D018913:Event-Related Potentials, P300 / Q000502:physiology*; D005260:Female; D015497:HIV-1; D006801:Humans; D008297:Male; D011596:Psychomotor Disorders / Q000175:diagnosis* / Q000821:virology*; D011930:Reaction Time; D012720:Severity of Illness Index