From genomics to mechanistic insight: a global perspective on molecular deficits induced by environmental agents.
As the postgenomic era continues to unfold, a new wave of scientific investigation is upon us focusing on the application of genomic technologies to study the meanings encrypted on the DNA code and the responses of living organisms to changes in their environment. Recent functional genomics studies in this laboratory have focused on the role of the aryl hydrocarbon receptor, a ubiquitous transcription factor, in genetic programming during renal development. Also of interest is the application of genomics investigations to the study of chronic medical conditions associated with early life exposures to environmental contaminants. Molecular evidence is discussed in this review within the framework of human molecular medicine.
Ramos
Kenneth S
KS
Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, University of Louisville, Louisville, Kentucky 40202, USA. ksramo01@luisville.edu
Steffen
Marlene C
MC
Falahatpisheh
M H
MH
Nanez
Adrian
A
D000818:Animals; D001564:Benzo(a)pyrene / Q000494:pharmacology; D004787:Environmental Pollution / Q000032:analysis / Q000517:prevention & control; D015870:Gene Expression / Q000187:drug effects; D023281:Genomics / Q000379:methods*; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D018336:Receptors, Aryl Hydrocarbon / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D015398:Signal Transduction / Q000187:drug effects; D025721:WT1 Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology
D018336:Receptors, Aryl Hydrocarbon; D025721:WT1 Proteins; D001564:Benzo(a)pyrene