Disrupting the stem cell niche: good seeds in bad soil.
Stem cells reside in a microenvironment or niche that is critical for stem cell maintenance and regulation. But what happens when a stem cell niche is disrupted? In this issue of Cell, two reports (Walkley et al., 2007a, 2007b) demonstrate in mice that alterations in the niche for hematopoietic stem cells lead to the development of myeloproliferative disease.
Perry
John M
JM
Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110, USA.
Li
Linheng
L
D000818:Animals; D001854:Bone Marrow Cells / Q000378:metabolism; D002453:Cell Cycle; D015973:Gene Expression Regulation, Leukemic; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D006801:Humans; D051379:Mice; D008954:Models, Biological; D009196:Myeloproliferative Disorders / Q000378:metabolism*; D010006:Osteoblasts / Q000378:metabolism