title: Severe transient cardiac failure caused by placental chorangiosis.
abstract: BACKGROUND
  Chorangiomas are villous capillary tumors of the placenta with high impact on neonatal morbidity and mortality. Cardiac complications have occasionally been reported.
  
  
  OBJECTIVE
  To elucidate clinical features, diagnosis and treatment of cardiac failure caused by chorangiomas.
  
  
  METHODS
  We report a case of a newborn, in whom massive chorangiomas were associated with severe cardiac failure, anemia, and thrombocytopenia.
  
  
  RESULTS
  Chorangiosis was not diagnosed prenatally. The pre-existing cardiac failure of the infant deteriorated soon after birth. Despite the severe stage, cardiac failure was reversible with intensive medical treatment including phosphodiesterase inhibitor. Complete recovery with no signs of cardiomyopathy was confirmed at the age of 5 months.
  
  
  CONCLUSIONS
  Severe cardiac failure in the neonate can be caused by chorangiosis. The time of diagnosis and treatment seems to be critical for the outcome of the infant. Prenatal treatment interventions should be considered.
authors.affiliation: Department of Neonatology, Campus Virchow Klinikum, Charité Universitatsmedizin Berlin, Berlin, Germany. thomas.schmitz@charite.de
authors.forename: Thomas
authors.initials: T
authors.lastname: Schmitz
authors.forename: Bernd
authors.initials: B
authors.lastname: Opgen-Rhein
authors.forename: Peter
authors.initials: P
authors.lastname: Kroschwald
authors.forename: Gunnar
authors.initials: G
authors.lastname: Schroeder
authors.forename: Sven
authors.initials: S
authors.lastname: Weber
authors.forename: Christoph
authors.initials: C
authors.lastname: Czernik
authors.forename: Michael
authors.initials: M
authors.lastname: Obladen
mesh_terms: D000328:Adult; D004452:Echocardiography; D005260:Female; D006333:Heart Failure / Q000000981:diagnostic imaging / Q000209:etiology*; D006339:Heart Rate; D006391:Hemangioma / Q000150:complications*; D006801:Humans; D007231:Infant, Newborn; D009929:Organ Size; D010920:Placenta / Q000033:anatomy & histology / Q000473:pathology; D010922:Placenta Diseases / Q000473:pathology*; D011247:Pregnancy; D013610:Tachycardia / Q000209:etiology; D016896:Treatment Outcome