title: Malignant calcifying epithelial odontogenic tumor of the mandible: report of a case with pulmonary metastasis showing remarkable response to platinum derivatives.
abstract: We describe a case of CEOT of the mandible, which underwent malignant transformation and developed metastatic tumors of the lung after repeated local recurrence. The primary tumor revealed typical histological features of benign CEOT showing sheets of polyhedral epithelial cells associated with abundant eosinophilic amyloid-like materials. On the other hand, the locally recurrent tumors had malignant features, such as increased nuclear pleomorphism with frequent mitotic figures and vascular invasion of tumor cells, as well as increased proliferative activity assessed by immunostaining for Ki-67. Chemotherapy was carried out against the pulmonary metastatic lesions, which showed a drastic response after 3 courses of intravenous administration of cisplatin (CDDP). To date, a total of 6 courses of CDDP and 6 courses of nedaplatin (CDGP) have been done, and the remaining pulmonary tumors have been dormant. This suggests that platinum derivatives could be a chemotherapeutic agent of choice against this rare tumor.
authors.affiliation: Division of Oral and Maxillo-Facial Surgery, Department of Oncological Science, Faculty of Medicine, Oita University, Hasama-machi, Yufu-shi, Oita, Japan. kekawano@med.oita-u.ac.jp
authors.forename: Kenji
authors.initials: K
authors.lastname: Kawano
authors.forename: Keiichiro
authors.initials: K
authors.lastname: Ono
authors.forename: Naomi
authors.initials: N
authors.lastname: Yada
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Takahashi
authors.forename: Kenji
authors.initials: K
authors.lastname: Kashima
authors.forename: Shigeo
authors.initials: S
authors.lastname: Yokoyama
authors.forename: Shigetaka
authors.initials: S
authors.lastname: Yanagisawa
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D016025:Bone Transplantation; D002945:Cisplatin / Q000627:therapeutic use*; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000556:secondary; D008297:Male; D008334:Mandible / Q000000981:diagnostic imaging / Q000601:surgery; D008339:Mandibular Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy* / Q000601:surgery; D018333:Odontogenic Cyst, Calcifying / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D009944:Organoplatinum Compounds / Q000627:therapeutic use; D011859:Radiography
chemical_list: D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; C053989:nedaplatin; D002945:Cisplatin