title: [A case of ductal carcinoma of the prostate after transurethral resection of prostate].
abstract: A 66-year-old man visited our hospital complaining of a high prostate-specific antigen (PSA) (6.9 ng/ml) and dysuria. Prostatic needle biopsies revealed no malignancy in January 1998 and February 1999 (PSA 8.0 ng/ml). Transurethral resection of prostate (TURP) was performed in March 1999. Although none of the TURP specimen showed any malignancy, the PSA level remained high (3.7 ng/ml 1 year after the TURP), and gradually increased. About 3 years later, re-biopsy was done (PSA 13.2 ng/ml) and pathological finding was moderately differentiated adenocarcinoma (Gleason score 3 + 3 = 6). After 9-month MAB, radical prostatectomy (RP) was performed in January 2003 (PSA 4.2 ng/ml). Though the RP specimen showed moderately differentiated adenocarcinoma with negative capsule penetration and negative surgical margins, PSA decreased to 2.5 ng/ml and gradually increased. Computed tomography (CT), magnetic resonance imaging (MRI), and bone scintigraphy showed neither distant metastasis nor local recurrence. Review of the RP specimen revealed ductal carcinoma with positive capsular penetration and suspicion of positive surgical margins. Although the patient was treated with maximum androgen blockade, diethylstilbestrol diphosphate, and tegafururacil, PSA gradually increased and was kept at a high level (5-6 ng/ml). In December 2005, the patient complained of anal pain and MRI showed a 4.8 x 2.3 cm tumor in the prostatic bed. Needle biopsy of the tumor revealed ductal carcinoma (PSA 6.39 ng/ml). In January 2006 (PSA 11.9 ng/ml), we initiated a treatment with 66 Gy of intensity modulated radiation therapy. In November 2006, PSA decreased to 0.279 ng/ml, and the tumor reduced (3.8 x 1.0 cm) on MRI.
authors.affiliation: The Department of Urology, Toshiba Rinkan Hospital.
authors.forename: Koji
authors.initials: K
authors.lastname: Izumi
authors.forename: Hitomi
authors.initials: H
authors.lastname: Kanno
authors.forename: Susumu
authors.initials: S
authors.lastname: Umemoto
authors.forename: Hisashi
authors.initials: H
authors.lastname: Hasumi
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Osada
authors.forename: Junichi
authors.initials: J
authors.lastname: Ota
authors.forename: Futoshi
authors.initials: F
authors.lastname: Tsuchiya
authors.forename: Ichiro
authors.initials: I
authors.lastname: Ogino
authors.forename: Masaoki
authors.initials: M
authors.lastname: Harada
mesh_terms: D000230:Adenocarcinoma / Q000532:radiotherapy / Q000601:surgery*; D000368:Aged; D044584:Carcinoma, Ductal / Q000532:radiotherapy / Q000601:surgery*; D003131:Combined Modality Therapy; D006801:Humans; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000209:etiology* / Q000532:radiotherapy; D011183:Postoperative Complications; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000532:radiotherapy / Q000601:surgery*; D011879:Radiotherapy Dosage; D020728:Transurethral Resection of Prostate
chemical_list: D017430:Prostate-Specific Antigen