Synthesis and biological action of novel 4-position-modified derivatives of D-myo-inositol 1,4,5-trisphosphate.
The design of a range of 4-position-modified D-myo-inositol 1,4,5-trisphosphate derivatives is described. The enantioselective synthesis of these compounds is reported, along with initial biological analysis, which indicates that these compounds do not act as D-myo-inositol 1,4,5-trisphosphate receptor agonists or antagonists.
Bello
Davide
D
EaStCHEM and School of Chemistry, Centre for Biomolecular Sciences, University of St Andrews, North Haugh, St Andrews, Fife, United Kingdom.
Aslam
Tashfeen
T
Bultynck
Geert
G
Slawin
Alexandra M Z
AM
Roderick
H Llewelyn
HL
Bootman
Martin D
MD
Conway
Stuart J
SJ
D002460:Cell Line; D018360:Crystallography, X-Ray; D015544:Inositol 1,4,5-Trisphosphate / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D021241:Spectrometry, Mass, Electrospray Ionization
D015544:Inositol 1,4,5-Trisphosphate