title: Iodocarbocyclization reaction of beta-ketoesters and alkynes.
abstract: Iodocyclopentenes are formed at room temperature upon straight reaction of delta-alkynyl-beta-ketoesters with I2 for several hours. Cyclizations involving terminal and substituted (alkyl, aryl, Br, I) alkynes were accessed. Twelve examples with yields ranging from 20% up to 80% are reported (out of them eight cases are above 60%). These results present the first examples of the iodonium-promoted 5-endo-dig carbocyclization of active methyne substrates onto alkynes.
authors.affiliation: Instituto Universitario de Química OrganometAlica Enrique Moles-Unidad Asociada al CSIC, Universidad de Oviedo, Oviedo 33071, Spain. barluenga@uniovi.es
authors.forename: José
authors.initials: J
authors.lastname: Barluenga
authors.forename: David
authors.initials: D
authors.lastname: Palomas
authors.forename: Eduardo
authors.initials: E
authors.lastname: Rubio
authors.forename: José M
authors.initials: JM
authors.lastname: Gonzalez