title: Toxicological evaluation of cigarettes with two banded cigarette paper technologies.
abstract: A tiered testing strategy has been employed to evaluate the potential of tobacco processes, ingredients, or technological developments to change the biological activity resulting from burning cigarette tobacco. The strategy is based on comparative chemical and biological testing. The introduction of banded cigarette papers in cigarettes to meet New York state "Fire Safety Standards for Cigarettes" constitutes an example of a technological development evaluated utilizing this tiered testing strategy that included a comparison of the chemical and biological effects of cigarettes with and without the banded cigarette paper technologies (BCPT) (representative of current marketed technologies). Specific testing included mainstream cigarette smoke chemistry studies; in vitro studies included genotoxicity (Ames and sister chromatid exchange) and cytotoxicity studies (neutral red); in vivo studies included a 13-week inhalation study in Sprague-Dawley rats and a 30-week dermal tumor promotion study in SENCAR mice. Collectively, data indicated that cigarettes with and without BCPT had a similar toxicological profile in this test battery.
authors.affiliation: Research and Development, R J Reynolds Tobacco Company (RJRT), Bowman Gray Technical Center, Winston-Salem, NC 27015, USA. theophe@rjrt.com
authors.forename: Eugenia H
authors.initials: EH
authors.lastname: Theophilus
authors.forename: Deborah H
authors.initials: DH
authors.lastname: Pence
authors.forename: Daniel R
authors.initials: DR
authors.lastname: Meckley
authors.forename: W
authors.initials: W
authors.lastname: Keith Shreve
authors.forename: Paul H
authors.initials: PH
authors.lastname: Ayres
authors.forename: Betsy R
authors.initials: BR
authors.lastname: Bombick
authors.forename: Michael F
authors.initials: MF
authors.lastname: Borgerding
authors.forename: Charles D
authors.initials: CD
authors.lastname: Garner
authors.forename: James E
authors.initials: JE
authors.lastname: Swauger
mesh_terms: D000280:Administration, Inhalation; D000287:Administration, Topical; D000818:Animals; D016466:CHO Cells / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D002470:Cell Survival / Q000187:drug effects; D006224:Cricetinae; D003412:Cricetulus; D004305:Dose-Response Relationship, Drug; D005260:Female; D007166:Immunosuppressive Agents / Q000633:toxicity; D008297:Male; D051379:Mice; D018632:Mice, Inbred SENCAR; D009499:Neutral Red; D010209:Paper; D051381:Rats; D017207:Rats, Sprague-Dawley; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics; D012854:Sister Chromatid Exchange / Q000187:drug effects / Q000235:genetics; D012878:Skin Neoplasms / Q000139:chemically induced / Q000473:pathology; D012906:Smoke / Q000009:adverse effects* / Q000032:analysis; D013638:Tars / Q000737:chemistry / Q000633:toxicity; D013672:Technology; D019460:Tobacco Industry / Q000379:methods*; D018675:Toxicity Tests; D062789:Tobacco Products
chemical_list: D007166:Immunosuppressive Agents; D012906:Smoke; D013638:Tars; C024746:tobacco tar; D009499:Neutral Red