title: Bone mineral status after treatment of malignant lymphoma in childhood and adolescence.
abstract: The relationship between bone mineral mass and cumulative dose of corticosteroids (CDC) was investigated in 42 children and adolescents treated for Hodgkin disease (HD; n = 22) and non-Hodgkin lymphoma (NHL; n = 20). The median age at the time of the study was 24.1 years for HD survivors and 14.1 years for NHL survivors. Dual-energy X-ray absorptiometry [bone mineral density of the lumbar spine (LS-BMD) expressed as Z-scores] and peripheral quantitative computed tomography at the distal radius [trabecular volumetric BMD (vBMD-trab)] were undertaken. Osteopenia (Z-score < -1.00) was found in 9/22 patients with HD and 10/20 with NHL, while 34% (HD = 6, NHL = 8) had a vBMD-trab below the normal range. The CDC correlated inversely with LS-BMD Z-score (r =-0.41, P = 0.007). There was a statistically significantly higher vBMD-trab in patients who received low (1-4 g/m(2)) compared with high (>or=20 g/m(2)) CDC (P = 0.031). Treatment of malignant lymphoma with high CDC is a risk factor for development of osteopenia.
authors.affiliation: McMaster University, McMaster Children's Hospital, Hamilton Health Sciences, Hamilton, Ontario, Canada.
authors.forename: A
authors.initials: A
authors.lastname: Sala
authors.forename: D
authors.initials: D
authors.lastname: Talsma
authors.forename: C
authors.initials: C
authors.lastname: Webber
authors.forename: S
authors.initials: S
authors.lastname: Posgate
authors.forename: S
authors.initials: S
authors.lastname: Atkinson
authors.forename: R
authors.initials: R
authors.lastname: Barr
mesh_terms: D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000009:adverse effects*; D015519:Bone Density / Q000187:drug effects* / Q000502:physiology; D001851:Bone Diseases, Metabolic / Q000139:chemically induced*; D002648:Child; D005260:Female; D006689:Hodgkin Disease / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D012307:Risk Factors
chemical_list: D000305:Adrenal Cortex Hormones