title: Bisphosphonate-related osteonecrosis of the jaw (BRONJ): run dental management designs and issues in diagnosis.
abstract: Recently, jawbone osteonecrosis has been largely reported as a potential adverse effect of bisphosphonate (BP) administration. Because of the peculiar pharmacokinetic and pharmacodynamic features of the BF (mainly for i.v. administration), their efficacy and large use, some major issues have to be taken into account extendedly both by oncologists and by dentists: 1) therapeutic dental protocol for patients with diagnosis of bisphosphonate-related osteonecrosis of the jaw (BRONJ); 2) dental strategies for patients in former or current i.v. BF treatment and in absence of BRONJ signs; 3) strategies for patients before i.v. BF treatment. Clinical features and guidelines for the management of this condition have been investigated and reported, sometimes with unclear indications; hence, on the basis of the literature and our clinical experience, major end points of this paper are providing our run protocols for the issues above described and, finally, focusing on a crucial, but not extensively investigated point: the early and correct diagnosis of BRONJ versus metastatic jaw lesions in cancer patients.
authors.affiliation: Section of Oral Medicine, Department of Oral Sciences, Università di Palermo, Palermo, Italy. giuca1@inwind.it
authors.forename: G
authors.initials: G
authors.lastname: Campisi
authors.forename: O
authors.initials: O
authors.lastname: Di Fede
authors.forename: A
authors.initials: A
authors.lastname: Musciotto
authors.forename: A
authors.initials: A
authors.lastname: Lo Casto
authors.forename: L
authors.initials: L
authors.lastname: Lo Muzio
authors.forename: F
authors.initials: F
authors.lastname: Fulfaro
authors.forename: G
authors.initials: G
authors.lastname: Badalamenti
authors.forename: A
authors.initials: A
authors.lastname: Russo
authors.forename: N
authors.initials: N
authors.lastname: Gebbia
mesh_terms: D050071:Bone Density Conservation Agents / Q000009:adverse effects*; D001859:Bone Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000556:secondary / Q000601:surgery; D003793:Dental Restoration, Permanent / Q000379:methods; D004164:Diphosphonates / Q000009:adverse effects*; D006801:Humans; D007573:Jaw Neoplasms / Q000139:chemically induced / Q000175:diagnosis* / Q000556:secondary / Q000601:surgery; D010020:Osteonecrosis / Q000139:chemically induced / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D010353:Patient Education as Topic / Q000379:methods
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates