title: SAR of a novel 'Anthranilamide Like' series of VEGFR-2, multi protein kinase inhibitors for the treatment of cancer.
abstract: Novel anthranilamides were surprisingly found to exert additional activity on B-RAF. Corresponding thiophene, pyrazole, and thiazole core analogs were prepared as VEGFR-2 inhibitors with c-KIT, and B-RAF activity. Compounds in the phenyl, thiophene, and thiazole series are in vivo active.
authors.affiliation: Department of Chemistry Research, Bayer Research Center, 400 Morgan Lane, West Haven, CT 06516, USA. pcwickens@hotmail.com
authors.forename: Philip
authors.initials: P
authors.lastname: Wickens
authors.forename: Harold
authors.initials: H
authors.lastname: Kluender
authors.forename: Julie
authors.initials: J
authors.lastname: Dixon
authors.forename: Catherine
authors.initials: C
authors.lastname: Brennan
authors.forename: Furahi
authors.initials: F
authors.lastname: Achebe
authors.forename: Antonella
authors.initials: A
authors.lastname: Bacchiocchi
authors.forename: Don
authors.initials: D
authors.lastname: Bankston
authors.forename: Donald
authors.initials: D
authors.lastname: Bierer
authors.forename: Michael
authors.initials: M
authors.lastname: Brands
authors.forename: Debbie
authors.initials: D
authors.lastname: Braun
authors.forename: Melissa S
authors.initials: MS
authors.lastname: Brown
authors.forename: Chih-Yuan
authors.initials: CY
authors.lastname: Chuang
authors.forename: Jacques
authors.initials: J
authors.lastname: Dumas
authors.forename: Istvan
authors.initials: I
authors.lastname: Enyedy
authors.forename: Gloria
authors.initials: G
authors.lastname: Hofilena
authors.forename: Zhenqiu
authors.initials: Z
authors.lastname: Hong
authors.forename: Tim
authors.initials: T
authors.lastname: Housley
authors.forename: Benjamin
authors.initials: B
authors.lastname: Jones
authors.forename: Uday
authors.initials: U
authors.lastname: Khire
authors.forename: Charles
authors.initials: C
authors.lastname: Kreiman
authors.forename: Ellalahewage
authors.initials: E
authors.lastname: Kumarasinghe
authors.forename: Timothy
authors.initials: T
authors.lastname: Lowinger
authors.forename: Ronda
authors.initials: R
authors.lastname: Ott-Morgan
authors.forename: Louise
authors.initials: L
authors.lastname: Perkins
authors.forename: Barton
authors.initials: B
authors.lastname: Phillips
authors.forename: Robert
authors.initials: R
authors.lastname: Schoenleber
authors.forename: William J
authors.initials: WJ
authors.lastname: Scott
authors.forename: Ryan
authors.initials: R
authors.lastname: Sheeler
authors.forename: Anikó
authors.initials: A
authors.lastname: Redman
authors.forename: Xiuying
authors.initials: X
authors.lastname: Sun
authors.forename: Ian
authors.initials: I
authors.lastname: Taylor
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.forename: Scott
authors.initials: S
authors.lastname: Wilhelm
authors.forename: Xiaomei
authors.initials: X
authors.lastname: Zhang
authors.forename: Mingbao
authors.initials: M
authors.lastname: Zhang
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Sullivan
authors.forename: Christopher
authors.initials: C
authors.lastname: Carter
authors.forename: Mark
authors.initials: M
authors.lastname: Miglarese
authors.forename: Joan
authors.initials: J
authors.lastname: Levy
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D045744:Cell Line, Tumor; D006801:Humans; D051379:Mice; D009369:Neoplasms / Q000188:drug therapy*; D047428:Protein Kinase Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D013329:Structure-Activity Relationship; D040301:Vascular Endothelial Growth Factor Receptor-2 / Q000037:antagonists & inhibitors*
chemical_list: D000970:Antineoplastic Agents; D047428:Protein Kinase Inhibitors; D040301:Vascular Endothelial Growth Factor Receptor-2