title: Deacylation studies on furanose triesters using an immobilized lipase: synthesis of a key precursor for bicyclonucleosides.
abstract: Lipozyme TL IM immobilized on silica catalyses the deacylation of 4-C-acyloxymethyl-3,5-di-O-acyl-1,2-O-(1-methylethylidene)-beta-L-threo-pentofuranose to form 3,5-di-O-acyl-4-C-hydroxymethyl-1,2-O-(1-methylethylidene)-alpha-d-xylo-pentofuranose in a highly selective and efficient manner.
authors.affiliation: Bioorganic Laboratory, Department of Chemistry, University of Delhi, Delhi 110 007, India.
authors.forename: Ashok K
authors.initials: AK
authors.lastname: Prasad
authors.forename: Neerja
authors.initials: N
authors.lastname: Kalra
authors.forename: Yogesh
authors.initials: Y
authors.lastname: Yadav
authors.forename: Rajesh
authors.initials: R
authors.lastname: Kumar
authors.forename: Sunil K
authors.initials: SK
authors.lastname: Sharma
authors.forename: Shamkant
authors.initials: S
authors.lastname: Patkar
authors.forename: Lene
authors.initials: L
authors.lastname: Lange
authors.forename: Jesper
authors.initials: J
authors.lastname: Wengel
authors.forename: Virinder S
authors.initials: VS
authors.lastname: Parmar
mesh_terms: D000215:Acylation; D002384:Catalysis; D002855:Chromatography, Thin Layer; D004800:Enzymes, Immobilized / Q000737:chemistry*; D004952:Esters / Q000737:chemistry; D007202:Indicators and Reagents; D008049:Lipase / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D009005:Monosaccharides / Q000737:chemistry*; D012822:Silicon Dioxide
chemical_list: D004800:Enzymes, Immobilized; D004952:Esters; D007202:Indicators and Reagents; D009005:Monosaccharides; D012822:Silicon Dioxide; D008049:Lipase