title: [Congenital factor XIII deficiency required high-dose factor XIII concentrate in late pregnancy].
abstract: Congenital factor XIII (FXIII) deficiency is a rare congenital hemorrhagic disorder. Since FXIII is an essential factor in pregnancy, pregnant patients with congenital FXIII deficiency should receive adequate replacement of FXIII concentrate. We report here on a 19-year-old pregnant woman with congenital FXIII deficiency. Despite regular replacement of FXIII concentrate, FXIII activity decreased rapidly after 32 weeks of gestation and she had to receive a high-dose of FXIII concentrate until delivery. Careful monitoring of FXIII activity is needed in patients with congenital FXIII deficiency, because FXIII activity may decrease rapidly in late pregnancy.
authors.affiliation: Division of Hematology, Department of Internal Medicine, Tokuyama Central Hospital.
authors.forename: Toru
authors.initials: T
authors.lastname: Takahashi
authors.forename: Katsuhiro
authors.initials: K
authors.lastname: Hatao
authors.forename: Munehiro
authors.initials: M
authors.lastname: Suzukawa
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Oji
mesh_terms: D000328:Adult; D005176:Factor XIII / Q000008:administration & dosage* / Q000032:analysis; D005177:Factor XIII Deficiency / Q000097:blood / Q000151:congenital* / Q000628:therapy*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011256:Pregnancy Outcome; D011263:Pregnancy Trimester, Third
chemical_list: D005176:Factor XIII