[Postoperative inflammatory reactions after coronary artery bypass grafting performed on-pump with preceding glucocorticoid therapy compared with those after grafting performed off-pump].
BACKGROUND
Compared with conventional coronary artery bypass graft surgery (CABG) using cardio-pulmonary bypass, less postoperative acute inflammatory responses are expected in off-pump CABG. Therefore, we retrospectively studied the difference in postoperative inflammatory reactions between on-pump and off-pump surgical groups.


METHODS
We selected 15 patients for on-pump and 19 for off-pump groups, respectively, from the past 3 years. One gram of methylpredonisolone was administered before institution of cardiopulmonary bypass only in the on-pump group. The white blood cell count and the level of C-reactive protein were compared in both groups for 10 days postoperatively.


RESULTS
The white blood cell count reached a maximum in each group 2 days after surgery. However the values were significantly greater in the on-pump group than in the off-pump group at postoperative days 3 through 6. The level of C-reactive protein was also increased postoperatively in each group. In the off-pump group without receiving any steroid therapy, the values were greater than in the on-pump group on postoperative days 1 through 6.


CONCLUSIONS
In off-pump CABG, the level of C-reactive protein increases significantly in the postoperative period.
Harasawa
Katsumi
K
Division of Anesthesia and Perioperative Medicine, Department of Anesthesiology and Critical Care Medicine, Hokkaido University Graduate School of Medicine, Sapporo 060-8638.
Morimoto
Yuji
Y
D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D002315:Cardiopulmonary Bypass / Q000009:adverse effects; D047549:Coronary Artery Bypass, Off-Pump; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D007249:Inflammation / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control*; D007958:Leukocyte Count; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage*; D011183:Postoperative Complications / Q000209:etiology / Q000517:prevention & control*; D012189:Retrospective Studies; D016896:Treatment Outcome
D015415:Biomarkers; D005938:Glucocorticoids; D002097:C-Reactive Protein; D008775:Methylprednisolone