title: Uneventful thoracic healing with everolimus after aortic valve replacement.
abstract: Impaired wound healing problems constitute a frequent severe adverse event associated to de novo use of proliferation signal inhibitors sirolimus or everolimus in kidney, heart, and lung transplantation. No published experience on the best practice to manage these drugs in patients scheduled for elective thoracic surgery is available. Herein we present a renal allograft recipient with recurrent cutaneous neoplasia who was maintained on everolimus plus prednisone undergoing aortic valve replacement. Although the most advisable practice may be everolimus withdrawal during the perioperative period, everolimus was maintained with transient dose decrease without any wound healing problem.
authors.affiliation: Department of Nephrology, Hospital Ramón y Cajal, Madrid, Spain. julpascual@gmail.com
authors.forename: Julio
authors.initials: J
authors.lastname: Pascual
authors.forename: Cristina
authors.initials: C
authors.lastname: Galeano
authors.forename: Daniel
authors.initials: D
authors.lastname: Celemín
authors.forename: Maria C
authors.initials: MC
authors.lastname: Alarcón
authors.forename: Roberto
authors.initials: R
authors.lastname: Marcén
authors.forename: Ana M
authors.initials: AM
authors.lastname: Fernández
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Burgos
authors.forename: Joaquin
authors.initials: J
authors.lastname: Ortuño
mesh_terms: D000368:Aged; D001021:Aortic Valve / Q000601:surgery*; D049109:Cell Proliferation / Q000187:drug effects*; D000068338:Everolimus; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D016030:Kidney Transplantation; D008297:Male; D015398:Signal Transduction / Q000187:drug effects*; D020123:Sirolimus / Q000009:adverse effects / Q000031:analogs & derivatives*; D014184:Transplantation, Homologous; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D007166:Immunosuppressive Agents; D000068338:Everolimus; D020123:Sirolimus