Intracranial self-stimulation of the dorsal raphe sensitizes psychostimulant locomotion.
The authors hypothesized that repeated rewarding electrical stimulation of the dorsal raphe can produce behavioral sensitization to psychostimulants. Groups of male rats were implanted with a stimulation electrode and preexposed to brain stimulation at parameters set to equate rewarding effectiveness across rats. Control groups were implanted with an electrode but never stimulated, or not implanted at all. Twenty-four hours after the 12th self-stimulation session, all groups were challenged with amphetamine (0.5 mg/kg, ip), nicotine (0.2 mg/kg, sc), or saline, and locomotor activity was measured for 1 hr. Locomotor responses to amphetamine and to nicotine were significantly greater in rats preexposed to brain stimulation. These findings suggest at least partial overlap of underlying substrates. ((c) 2007 APA, all rights reserved).
Boye
Sandra M
SM
Centre de Recherche Fernand-Seguin, Hôpital Louis-H. Lafontaine, Montréal, Québec, Canada. sandra.boye@umontreal.ca
Grant
Rebecca J
RJ
Tawfik
Vivianne L
VL
D000661:Amphetamine / Q000494:pharmacology; D000704:Analysis of Variance; D000818:Animals; D001522:Behavior, Animal; D004307:Dose-Response Relationship, Radiation; D004558:Electric Stimulation / Q000379:methods*; D005106:Exploratory Behavior / Q000187:drug effects / Q000528:radiation effects; D008297:Male; D009043:Motor Activity / Q000187:drug effects* / Q000528:radiation effects*; D009538:Nicotine / Q000494:pharmacology; D011619:Psychotropic Drugs / Q000494:pharmacology*; D011903:Raphe Nuclei / Q000528:radiation effects*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012653:Self Stimulation
D011619:Psychotropic Drugs; D009538:Nicotine; D000661:Amphetamine