title: Radiofrequency ablation combined with reduction of hepatic blood flow: effect of Lipiodol on coagulation diameter and ablation time in normal pig liver.
abstract: OBJECTIVE
  We evaluated the effectiveness of radiofrequency (RF) ablation combined with transarterial embolization using Lipiodol and gelatin sponge.
  
  
  METHODS
  A total of 18 normal pig liver lobes were randomly assigned to the following three different RF ablation groups, 1) combined with TAE using Lipiodol and gelatin sponge as "LpTAE group"; 2) combined with TAE using gelatin sponge only as "TAE group"; 3) ablation alone as "control group". Ablations were performed under open laparotomy using an RF generator and a 2-cm expandable needle. The diameter of coagulation and the ablation time were compared among the three groups.
  
  
  RESULTS
  The characteristic shape of coagulated area differed among the three groups. The long-axis diameter showed no significant difference among the three groups (27.5mm, 27.5mm, 26.7mm; respectively), while the short-axis diameter was significantly larger in the LpTAE group compared with the control groups (25.2mm vs. 20.5mm; p < 0.05). The total ablation time was significantly shorter in the LpTAE and TAE groups compared with the control group (166, 204 seconds vs. 309 seconds; p = 0.001, p = 0.01).
  
  
  CONCLUSIONS
  RF ablation combined with LpTAE produced larger and more spherical areas of coagulation in a shorter ablation time. Such an advantage could potentially enhance the clinical effectiveness of RF ablation.
authors.affiliation: Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kinki University School of Medicine, Osaka-sayama, Japan.
authors.forename: Hobyung
authors.initials: H
authors.lastname: Chung
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Kudo
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Minami
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Kawasaki
mesh_terms: D000818:Animals; D017115:Catheter Ablation / Q000379:methods*; D004621:Embolization, Therapeutic / Q000379:methods*; D005780:Gelatin / Q000008:administration & dosage; D007459:Iodized Oil / Q000008:administration & dosage*; D008099:Liver / Q000098:blood supply* / Q000473:pathology / Q000601:surgery*; D009336:Necrosis; D012039:Regional Blood Flow; D013552:Swine; D013997:Time Factors
chemical_list: D007459:Iodized Oil; D005780:Gelatin