title: Pharmacokinetics of albendazole sulfoxide enantiomers administered in racemic form and separately in rats.
abstract: The pharmacokinetic behaviour of albendazole sulfoxide (ABZSO) enantiomers was studied in rats after the oral administration of 10 mg/kg of rac-ABZSO, 5 mg/kg of (-)-ABZSO or 5 mg/kg of (+)-ABZSO. The disposition profiles of ABZSO enantiomers were similar in all treatments, but the calculated area under the curve for the (-)-ABZSO was higher in all cases compared with (+)-ABZSO. The results suggest that there is no chiral inversion of ABZSO enantiomers. After the administration of rac-ABZSO, 17.2% of the total dose was recovered in urine as albendazole ABZ (0.1%), albendazole sulfone ABZSO(2) (0.3%), albendazole 2-aminosulfone (ABZ-SO(2)NH(2)) (3.1%) and ABZSO (13.7%). The ratio (+) to (-) was similar in urine (1.6) and blood (1.7).
authors.affiliation: Secção de Farmacologia e Toxicologia, Departamento de Para-Clínicas, Faculdade de Veterinária, Universidade Eduardo Mondlane, Maputo, Mozambique. bpscapece@yahoo.com
authors.forename: Bettencourt P S
authors.initials: BP
authors.lastname: Capece
authors.forename: Gloria
authors.initials: G
authors.lastname: Castells
authors.forename: Carlo
authors.initials: C
authors.lastname: Godoy
authors.forename: Margarita
authors.initials: M
authors.lastname: Arboix
authors.forename: Carles
authors.initials: C
authors.lastname: Cristòfol
mesh_terms: D000284:Administration, Oral; D015766:Albendazole / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000737:chemistry / Q000493:pharmacokinetics; D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage / Q000097:blood / Q000737:chemistry* / Q000493:pharmacokinetics*; D004305:Dose-Response Relationship, Drug; D007536:Isomerism; D051381:Rats
chemical_list: D000871:Anthelmintics; D015766:Albendazole; C027186:albendazole sulfoxide