title: [Changes of serum nitric oxide level after acute hepatic injury in mice and the effect of yugan capsule on it].
abstract: OBJECTIVE
  To observe the changes of serum nitric oxide (NO) level after acute hepatic injury (AHI) in mice and the effect of Yugan capsule (YC) on it.
  
  
  METHODS
  The mouse AHI model was induced by carbon tetrachloride ( CC14 ) at different time points. After treatment with or without YC, serum nitric oxide ( NO) , anlanine aminotransferase (ALT) and aspartate aminotransferase (AST) were detected, and liver histopathologic injury was observed at different time points after AHI, respectively.
  
  
  RESULTS
  Serum NO, ALT and AST in the model group escalated significantly with time going, while they decreased and liver histopathologic injury was improved in the YC groups.
  
  
  CONCLUSIONS
  The serum levels of NO, ALT and AST increased,and liver histopathologic injury gradually aggravated with time going after CCl4 injection. Yugan capsule could decrease the levels of ALT, AST and NO.
authors.affiliation: The Second Hospital Affiliated to Xiangya Medical College, Zhongnan University, Changsha. xinc08@yahoo.com.cn
authors.forename: Xin
authors.initials: X
authors.lastname: Cheng
authors.forename: Chao-liang
authors.initials: CL
authors.lastname: Xie
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D001219:Aspartate Aminotransferases / Q000097:blood; D056486:Chemical and Drug Induced Liver Injury / Q000097:blood* / Q000188:drug therapy / Q000201:enzymology; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D051379:Mice; D009569:Nitric Oxide / Q000097:blood*; D013607:Tablets
chemical_list: D000975:Antioxidants; D004365:Drugs, Chinese Herbal; D013607:Tablets; C550194:yugan; D009569:Nitric Oxide; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase