Effect of a selective nonsteroidal anti-inflammatory drug, celecoxib, on the reproductive function of female mice.
BACKGROUND
The aim of the present study was to determine if long-term use of a cyclooxygenase-2 (COX-2) inhibitor affects fertility or ovulation in female mice.


METHODS
Twenty-four female mice, 25 days of age, were given a selective COX-2 inhibitor: 3 mg/kg celecoxib (n = 8), 5 mg/kg celecoxib (n = 8),or placebo (n = 8) in a random fashion. Eight female mice, 10-11 weeks old, given 3 mg/kg celecoxib (n = 4) or placebo (n = 4) were subjected to continuous mating studies.


RESULTS
Results from the 24 mice (n = 8 for each group) showed that oocyte number was not significantly different between female mice treated with either 3 mg/kg or 5 mg/kg celecoxib and placebo (21.4 +/- 2.5, 21.5 +/- 3.3, 23.3 +/- 3.8, respectively). From the continuous mating study, the litter size of female mice treated with celecoxib was not significantly different (8.2 +/- 1.3 pups/litter) compared to those treated with placebo (8.3 +/- 1.2 pups/litter). In addition, female mice treated with celecoxib had an average of 2.8 +/- 0.5 litters in a 12-week period, which was similar to female mice treated with placebo (3.0 +/- 0.8 litters/female).


CONCLUSIONS
This study suggests that use of low-dose (<or= 5 mg/kg) selective COX-2 inhibitor in a mouse model does not significantly impair the female reproductive function.
Wang
Peng-Hui
PH
Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taiwan, R.O.C. phwang@vghtpe.gov.tw
Horng
Huann-Cheng
HC
Chen
Yi-Jen
YJ
Hsieh
Shie-Liang
SL
Chao
Hsiang-Tai
HT
Yuan
Chiou-Chung
CC
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000633:toxicity*; D000068579:Celecoxib; D052246:Cyclooxygenase 2 Inhibitors / Q000633:toxicity*; D005260:Female; D005298:Fertility / Q000187:drug effects; D051379:Mice; D008807:Mice, Inbred BALB C; D010060:Ovulation / Q000187:drug effects; D011720:Pyrazoles / Q000633:toxicity*; D012098:Reproduction / Q000187:drug effects*; D013449:Sulfonamides / Q000633:toxicity*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D052246:Cyclooxygenase 2 Inhibitors; D011720:Pyrazoles; D013449:Sulfonamides; D000068579:Celecoxib