TRP's: links to schizophrenia?
Schizophrenia is a chronic psychiatric disorder the cause of which is unknown. It is considered to be a neurodevelopmental disorder that results from an interaction of genetic and environmental factors. Direct evidence for links between schizophrenia and TRP channels is lacking. However, several aspects of the pathophysiology of the disorder point to a possible involvement of TRP channels. In this review evidence for links between TRP channels and schizophrenia with respect to neurodevelopment, dopaminergic and cannabinoid systems, thermoregulation, and sensory processes, is discussed. Investigation of these links holds the prospect of a new understanding of schizophrenia with resultant therapeutic advances.
Chahl
Loris A
LA
Centre for Mental Health Studies and Schizophrenia Research Institute, James Fletcher Hospital, University of Newcastle, New South Wales, 2308 Australia. loris.chahl@newcastle.edu.au
D000818:Animals; D001833:Body Temperature Regulation / Q000502:physiology; D001921:Brain / Q000187:drug effects / Q000254:growth & development; D002211:Capsaicin / Q000494:pharmacology; D006801:Humans; D009475:Neurons, Afferent / Q000502:physiology; D051381:Rats; D043882:Receptors, Cannabinoid / Q000378:metabolism / Q000502:physiology; D011954:Receptors, Dopamine / Q000378:metabolism / Q000502:physiology; D012559:Schizophrenia / Q000209:etiology* / Q000235:genetics / Q000503:physiopathology*; D013569:Synapses / Q000502:physiology; D050051:Transient Receptor Potential Channels / Q000235:genetics / Q000502:physiology*
D043882:Receptors, Cannabinoid; D011954:Receptors, Dopamine; D050051:Transient Receptor Potential Channels; D002211:Capsaicin