Recurrent pleomorphic adenoma of the parotid gland: analysis of 108 consecutive patients.
BACKGROUND
Surgery for recurrent parotid pleomorphic adenoma is a challenging problem.


METHODS
One hundred eight patients who underwent 134 reoperations for recurrent parotid pleomorphic adenoma (follow-up, 22 years) were evaluated for histopathologic features and risk factors for recurrence.


RESULTS
The number of reoperations for tumor recurrence ranged from 1 to 10. Twenty-seven patients (25%) developed permanent facial nerve weakness. The risks for clinically evident rerecurrence after 1, 5, and 15 years were 16%, 42%, and 75%, respectively. Female sex, young age at initial treatment, and enucleation instead of parotidectomy for treatment of the first recurrence were significant risk factors for rerecurrence. The mean number of recurrent tumor nodules was 26.


CONCLUSIONS
Surgery for recurrent parotid pleomorphic adenoma has a high rate of facial nerve morbidity. The chance of rerecurrence is high. Extended parotidectomy seems to be the best approach for the reoperation to reduce the risk of rerecurrence.
Wittekindt
Claus
C
Clinic of Otorhinolaryngology, Head and Neck Surgery, University of Cologne, D-50924 Cologne, Germany.
Streubel
Kristina
K
Arnold
Georg
G
Stennert
Eberhard
E
Guntinas-Lichius
Orlando
O
D008949:Adenoma, Pleomorphic / Q000601:surgery*; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000601:surgery*; D010307:Parotid Neoplasms / Q000601:surgery*; D012086:Reoperation; D012189:Retrospective Studies; D012737:Sex Factors