New triterpene glucosides, oligoporins A-C, from Oligoporus tephroleucus protect DNA from Fenton reaction.
New triterpene glucosides, oligoporins A (1), B (2), and C (3), were isolated from the methanolic extract of the fruiting bodies of Oligoporus tephroleucus (Polyporaceae). Their structures were established by spectroscopic methods. These compounds significantly exhibited protective effect to plasmid DNA damage by hydroxyl radical (*OH) generated from the Fenton reaction with hydrogen peroxide and ferrous.
Lee
In-Kyoung
IK
Functional Metabolomics Research Center, KRIBB, Yuseong, Daejeon, Republic of Korea.
Jang
Yun-Woo
YW
Yu
Seung Hun
SH
Yun
Bong-Sik
BS
D000818:Animals; D001487:Basidiomycota / Q000378:metabolism*; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D004247:DNA / Q000737:chemistry*; D004249:DNA Damage; D053938:DNA Fragmentation; D015195:Drug Design; D005960:Glucosides / Q000737:chemistry* / Q000494:pharmacology; D006861:Hydrogen Peroxide / Q000737:chemistry / Q000494:pharmacology; D017665:Hydroxyl Radical; D007501:Iron / Q000737:chemistry / Q000494:pharmacology; D008956:Models, Chemical; D013053:Spectrophotometry / Q000379:methods; D014315:Triterpenes / Q000737:chemistry* / Q000494:pharmacology
C045076:Fenton's reagent; D005960:Glucosides; D014315:Triterpenes; C524216:oligoporin A; C524217:oligoporin B; C524218:oligoporin C; D017665:Hydroxyl Radical; D004247:DNA; D006861:Hydrogen Peroxide; D007501:Iron