title: [Analysis of survival and factors affecting the survival after surgical resection of peripheral cholangiocarcinoma: 318 cases in single institute].
abstract: OBJECTIVE
  Although the survival rate after surgical resection of peripheral cholangiocarcinoma is low, surgical resection is only potentially curative therapy. The aim of this study is to evaluate clinicopathological factors affecting survival after surgical resection of peripheral cholangiocarcinoma.
  
  
  METHODS
  Between February 1990 and December 2005, surgical intervention with curative intent was performed on 318 patients and 292 patients underwent resection. We retrospectively analyzed survival data of 318 patients and clinicopathological factors affecting survival by reviewing the medical record.
  
  
  RESULTS
  Among the 292 cases of resection, curative resection with tumor-free margin (R0) has been resulted in 221 cases. The 1-, 3-, 5- and 10-year survival rate of R0 resection were 74.9, 46.9, 36.9 and 15.2%, respectively. The survival rate of patient undergoing R0 resection was significantly better than that of R1, R2 or nonresection. Multivariate analysis showed that curative resectability, macroscopic type of tumor and lymph node metastasis were statically significant independent prognostic factors.
  
  
  CONCLUSIONS
  The survival after surgical resection of peripheral cholangiocarcinoma depends on curability of surgical resection, macroscopic type of tumor and status of lymph node. Particularly in R0 resection for intraductal growth type without lymph node metastasis, there is great chance for long-term survival. Surgical resection attaining tumor free margin should be attempted if liver function and general condition of patient are acceptable for hepatectomy.
authors.affiliation: Division of Hepatobiliary Surgery and Liver Transplantation, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: Gi Won
authors.initials: GW
authors.lastname: Song
authors.forename: Sung Gyu
authors.initials: SG
authors.lastname: Lee
authors.forename: Young Joo
authors.initials: YJ
authors.lastname: Lee
authors.forename: Kwang Min
authors.initials: KM
authors.lastname: Park
authors.forename: Shin
authors.initials: S
authors.lastname: Hwang
authors.forename: Ki Hun
authors.initials: KH
authors.lastname: Kim
authors.forename: Chul Soo
authors.initials: CS
authors.lastname: Ahn
authors.forename: Deok Bog
authors.initials: DB
authors.lastname: Moon
authors.forename: Tae Yong
authors.initials: TY
authors.lastname: Ha
authors.forename: Dong Hwan
authors.initials: DH
authors.lastname: Jung
mesh_terms: D000368:Aged; D001650:Bile Duct Neoplasms / Q000175:diagnosis / Q000401:mortality* / Q000601:surgery; D001653:Bile Ducts, Intrahepatic; D018281:Cholangiocarcinoma / Q000175:diagnosis / Q000401:mortality* / Q000601:surgery; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome