title: Comparison of breast cancer detection by diffusion-weighted magnetic resonance imaging and mammography.
abstract: OBJECTIVE
  Breast cancer-detecting ability of diffusion-weighted magnetic resonance imaging (DW-MRI) was investigated by comparing the breast cancer detection rates of DW-MRI and mammography (MMG).
  
  
  METHODS
  The subjects were 48 women who had breast cancer (53 cancer lesions) who underwent DW-MRI before surgery. Altogether, 41 lesions were invasive ductal carcinoma (IDC), 7 were noninvasive ductal carcinoma (NIDC) and 5 were "others."
  
  
  RESULTS
  The breast cancer detection rates by MMG and DW-MRI were 84.9% and 94.3% (P < 0.001), respectively. In each classification of histology and size, the detection rate by DW-MRI was higher than that by MMG. In relation to the mammary gland density, the detection rates of fatty, scattered, heterogeneously dense, and extremely dense mammary glands were 100%, 100%, 92.0%, and 83.3%, respectively. The mean apparent diffusion coefficient values of the histologic types were 1.07 +/- 0.17 x 10(-3), 1.50 +/- 0.24 x 10(-3), 1.12 +/- 0.25 x 10(-3), and 2.01 +/- 0.29 x 10(-3) mm(2)/s for IDC, NIDC, others, and normal breast, respectively, showing that the values of IDC and NIDC were significantly different from that of the normal breast (P < 0.001 each). A significant difference was also noted between IDC and NIDC (P < 0.001).
  
  
  CONCLUSIONS
  DW-MRI may be useful for detecting breast cancer in a wide age group of women, including young women with dense mammary glands.
authors.affiliation: Department of Diagnostic and Therapeutic Radiology, Ehime University Graduate School of Medicine, Shitsukawa, Toon, 791-0295, Japan. mihoyoshikawa@yahoo.co.jp
authors.forename: Miho I
authors.initials: MI
authors.lastname: Yoshikawa
authors.forename: Shozo
authors.initials: S
authors.lastname: Ohsumi
authors.forename: Shigenori
authors.initials: S
authors.lastname: Sugata
authors.forename: Masaaki
authors.initials: M
authors.lastname: Kataoka
authors.forename: Shigemitsu
authors.initials: S
authors.lastname: Takashima
authors.forename: Keiichi
authors.initials: K
authors.lastname: Kikuchi
authors.forename: Teruhito
authors.initials: T
authors.lastname: Mochizuki
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D008327:Mammography / Q000379:methods*; D008875:Middle Aged; D012189:Retrospective Studies