Improved rejection of multiply scattered photons in confocal microscopy using dual-axes architecture.
We perform Monte Carlo simulations to show that the dual-axes (DA) confocal architecture has superior rejection of multiply scattered photons in tissue to that of single axis. As a result, the DA configuration provides improved signal-to-noise ratio and dynamic range, and thus is sensitive to ballistic photons from deeper within tissue, features that are particularly useful for performing vertical cross-sectional reflectance images in tissue.
Wong
Larry K
LK
Stanford University, CA 94305, USA. lkcwong@stanford.edu
Mandella
Michael J
MJ
Kino
Gordon S
GS
Wang
Thomas D
TD
D016880:Anisotropy; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004867:Equipment Design; D018613:Microscopy, Confocal / Q000295:instrumentation* / Q000379:methods; D015233:Models, Statistical; D008962:Models, Theoretical; D009010:Monte Carlo Method; D055095:Optics and Photonics; D017785:Photons; D012542:Scattering, Radiation