No association between the DAT1 10-repeat allele and ADHD in the Iranian population.
Association studies between attention-deficit hyperactivity disorder (ADHD) and the 10-repeat allele of a polymorphism (a 40 bp variable number of tandem repeats) in the dopamine transporter gene (DAT1) have resulted in mixed findings in different populations. We performed a case/control study to clarify the contribution of this allele with ADHD in the Iranian population. No association was observed between the 10-allele and disease (chi(2) = 0.081, P < 0.9). Furthermore, no significant difference was observed in the homozygosity of this allele between the case and control groups (chi(2) = 0.022, P < 0.9). Implication of the dopamine transporter gene in the pathophysiology of ADHD warrants investigation of other functional polymorphisms within this gene in the Iranian ADHD patients.
Banoei
M M
MM
National Institute for Genetic Engineering and Biotechnology, Tehran, Iran.
Majidizadeh
T
T
Shirazi
E
E
Moghimi
N
N
Ghadiri
M
M
Najmabadi
H
H
Ohadi
M
M
D000293:Adolescent; D000483:Alleles; D001289:Attention Deficit Disorder with Hyperactivity / Q000208:ethnology / Q000235:genetics*; D016022:Case-Control Studies; D002648:Child; D050483:Dopamine Plasma Membrane Transport Proteins / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007492:Iran; D008297:Male; D011110:Polymorphism, Genetic; D044382:Population Groups / Q000235:genetics
D050483:Dopamine Plasma Membrane Transport Proteins; C493214:SLC6A3 protein, human