title: Polyelectrolyte complexes based on (quaternized) poly[(2-dimethylamino)ethyl methacrylate]: behavior in contact with blood.
abstract: Polyelectrolyte complexes (PECs) between (quaternized) poly[2-(dimethylamino)ethyl methacrylate] (PDMAEMA) and (crosslinked) N-carboxyethylchitosan (CECh) or poly(2-acrylamido-2-methylpropane sodium sulfonate) (PAMPSNa) were prepared and characterized in terms of their stability, equilibrium water content, and surface morphology. The evaluation of the behavior of the studied PECs in contact with blood revealed that the (crosslinked) CECh/(quaternized) PDMAEMA complexes had lost the inherent PDMAEMA cytotoxicity but still preserved haemostatic activity. In contrast, the complex formation between (quaternized) PDMAEMA and PAMPSNa allowed the preparation of materials with improved blood compatibility.
authors.affiliation: Laboratory of Bioactive Polymers, Institute of Polymers, Bulgarian Academy of Sciences, Acad. G. Bonchev Street Bl. 103A, 1113 Sofia, Bulgaria.
authors.forename: Elena
authors.initials: E
authors.lastname: Yancheva
authors.forename: Dilyana
authors.initials: D
authors.lastname: Paneva
authors.forename: Dobri
authors.initials: D
authors.lastname: Danchev
authors.forename: Laetitia
authors.initials: L
authors.lastname: Mespouille
authors.forename: Philippe
authors.initials: P
authors.lastname: Dubois
authors.forename: Nevena
authors.initials: N
authors.lastname: Manolova
authors.forename: Iliya
authors.initials: I
authors.lastname: Rashkov
mesh_terms: D001672:Biocompatible Materials / Q000138:chemical synthesis*; D001769:Blood / Q000187:drug effects*; D001772:Blood Cell Count; D001777:Blood Coagulation / Q000187:drug effects; D048271:Chitosan / Q000031:analogs & derivatives / Q000737:chemistry; D003432:Cross-Linking Reagents / Q000737:chemistry; D016503:Drug Delivery Systems; D018014:Gene Transfer Techniques; D006490:Hemostatics; D006801:Humans; D008689:Methacrylates / Q000737:chemistry* / Q000494:pharmacology / Q000633:toxicity; D009757:Nylons / Q000737:chemistry* / Q000494:pharmacology / Q000633:toxicity; D011108:Polymers / Q000737:chemistry; D013451:Sulfonic Acids / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials; D003432:Cross-Linking Reagents; D006490:Hemostatics; D008689:Methacrylates; C495631:N-(2-carboxyethyl)chitosan; D009757:Nylons; D011108:Polymers; D013451:Sulfonic Acids; C407037:poly(2-(dimethylamino)ethyl methacrylate); C077118:poly(2-acrylamido-2-methyl-1-propanesulfonic acid); D048271:Chitosan