title: Expression of epidermal growth factor, fibroblast growth factor-2, and platelet-derived growth factor-A in the eutopic endometrium of women with endometriosis.
abstract: OBJECTIVE
  The objective of the present study was to compare the levels of expression of epidermal growth factor (EGF), fibroblast growth factor-2 (FGF-2), and platelet-derived growth factor-A (PDGF-A) mRNA in the eutopic endometrium of women with and without endometriosis.
  
  
  METHODS
  Thirty-five women with advanced stage endometriosis and 31 control women were recruited. Following isolation of total RNA from endometrial tissue and reverse transcription, cDNA samples were amplified to quantify the level of expression of EGF, FGF-2, PDGF-A.
  
  
  RESULTS
  While the levels of mRNA of EGF and FGF-2 were not different between the two groups, the PDGF-A mRNA level was significantly lower in the endometriosis group than in the control group during the secretory phase (6.12 +/- 0.51 vs 12.50 +/- 0.99, mean +/- SEM, P < 0.05).
  
  
  CONCLUSIONS
  The expression level of PDGF-A, but not EGF and FGF-2, might be decreased during the secretory phase in the eutopic endometrium of women with advanced stage endometriosis.
authors.affiliation: Department of Obstetrics and Gynecology, College of Medicine, University of Ulsan, Asan Medical Center, Seoul, Korea.
authors.forename: Sa-Ra
authors.initials: SR
authors.lastname: Lee
authors.forename: Sung-Hoon
authors.initials: SH
authors.lastname: Kim
authors.forename: Young-Jin
authors.initials: YJ
authors.lastname: Lee
authors.forename: Seok-Ho
authors.initials: SH
authors.lastname: Hong
authors.forename: Hee-Dong
authors.initials: HD
authors.lastname: Chae
authors.forename: Chung-Hoon
authors.initials: CH
authors.lastname: Kim
authors.forename: Byung-Moon
authors.initials: BM
authors.lastname: Kang
authors.forename: Young-Min
authors.initials: YM
authors.lastname: Choi
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D004715:Endometriosis / Q000378:metabolism*; D004717:Endometrium / Q000378:metabolism*; D004815:Epidermal Growth Factor / Q000378:metabolism*; D005260:Female; D016222:Fibroblast Growth Factor 2 / Q000378:metabolism*; D006801:Humans; D008183:Luteal Phase / Q000378:metabolism; D010982:Platelet-Derived Growth Factor / Q000378:metabolism*
chemical_list: D010982:Platelet-Derived Growth Factor; C075278:platelet-derived growth factor A; D016222:Fibroblast Growth Factor 2; D004815:Epidermal Growth Factor