[Study on expression of matrix metalloproteinase-2 and matrix metalloproteinase-9 in brain tissue adjacent to hemorrhage after brain hemorrhage in human].
OBJECTIVE
To investigate the expression and significance of matrix metalloproteinase-2 (MMP-2) and MMP-9 in peri-hematoma brain tissues after acute brain hemorrhage in human.


METHODS
Forty-two patients with acute brain hemorrhage received surgery, the brain tissues adjacent to hemorrhagic site were obtained during surgery, and positive expressions of MMP-2 and MMP-9 were determined with immunohistochemical staining. Brain tissues from 30 patients with cerebral trauma were obtained to serve as controls.


RESULTS
The positive expressions of MMP-2 and MMP-9 in focal brain tissues were significantly elevated in early acute brain hemorrhage. Compared with 28 and 27 cases with MMP-2 and MMP-9 positive expression respectively in control group, there were 39 and 37 cases with MMP-2 and MMP-9 positive expression respectively in acute brain hemorrhage group. There were no significant differences between two groups (both P>0.05).


CONCLUSIONS
MMP-2 and MMP-9 might contribute to brain edema formation in the acute intra-cerebral hemorrhage of human.
Ke
Shao-fa
SF
Taizhou Hospital, Wenzhou Medical College, Linhai 317000, Zhejiang, China.
Jin
Xiao-ping
XP
Zhang
Ke-hao
KH
Wang
Jun-xing
JX
Hu
Xiao-ming
XM
Zhang
Dan-hong
DH
Chen
Qiu-yue
QY
Zhou
Yuan-lin
YL
D000328:Adult; D000368:Aged; D001921:Brain / Q000201:enzymology*; D002543:Cerebral Hemorrhage / Q000201:enzymology*; D005260:Female; D006801:Humans; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000378:metabolism*; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism*; D008875:Middle Aged
C522361:MMP2 protein, human; D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9