[Adiponectin and atherosclerosis].
Obesity combined with other components of the insulin resistance syndrome is an important risk factor for atherosclerosis and its complications. The exact mechanisms through which the above diseases are linked have not yet been fully elucidated. One of the possible links may be a disturbance of the endocrine function of the adipose tissue of obese persons which produces an increased amount of proinflammatory and proatherogenic hormones and a lower amount of factors protecting against such pathologies. Adiponectin is the only hormone produced by the adipose tissue with a proven antiinflammatory and antiatherosclerotic effect. This hormone is predominantly produced by adipocytes and its concentrations are decreased in patients with obesity, insulin resistance and atherosclerosis. The objective of the article is to summarize current experimental and clinical knowledge of the links between adiponectin and atherosclerosis and to discuss possible utilization of adiponectin as a marker for atherosclerosis, and the potential for its exploitation in the prevention and/or treatment of atherosclerosis.
Haluzíková
D
D
II. interní klinika 1. lékarské fakulty UK a VFN Praha. dhalu@lf1.cuni.cz
Roubícek
T
T
Haluzík
M
M
D052242:Adiponectin / Q000032:analysis / Q000378:metabolism* / Q000502:physiology; D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D050197:Atherosclerosis / Q000150:complications / Q000175:diagnosis / Q000378:metabolism*; D015415:Biomarkers / Q000032:analysis; D006801:Humans; D007333:Insulin Resistance; D009765:Obesity / Q000150:complications / Q000378:metabolism
D052242:Adiponectin; D015415:Biomarkers