Case of localized bullous pemphigoid with unique clinical manifestations in the lower legs.
We report the case of a 71-year-old Japanese woman who presented with persistent band-like erosions in the lower legs. Histological examination suggested subepidermal blister formation. Direct and indirect immunofluorescence studies revealed tissue-deposited and circulating immunoglobulin G autoantibodies against the basement membrane. Western blotting revealed autoantibodies to BP230, but not to BP180. Based on these findings, the patient was diagnosed as having a localized type of bullous pemphigoid. We suggest that the unique clinical manifestations in this patient could be attributable to bacterial or fungal infection, and/or mechanical trauma, such as the pressure of her socks.
Kohroh
Kazuhiro
K
Department of Dermatology, Juntendo University School of Medicine, Bunkyo-ku, Tokyo, Japan.
Suga
Yasushi
Y
Mizuno
Yuki
Y
Ishii
Norito
N
Hashimoto
Takashi
T
Ikeda
Shigaku
S
D000368:Aged; D001323:Autoantibodies / Q000097:blood; D005260:Female; D006801:Humans; D007159:Immunologic Tests; D007866:Leg / Q000473:pathology*; D010391:Pemphigoid, Bullous / Q000276:immunology / Q000473:pathology*; D012867:Skin / Q000276:immunology / Q000473:pathology*
D001323:Autoantibodies