title: Putting feelings into words: affect labeling disrupts amygdala activity in response to affective stimuli.
abstract: Putting feelings into words (affect labeling) has long been thought to help manage negative emotional experiences; however, the mechanisms by which affect labeling produces this benefit remain largely unknown. Recent neuroimaging studies suggest a possible neurocognitive pathway for this process, but methodological limitations of previous studies have prevented strong inferences from being drawn. A functional magnetic resonance imaging study of affect labeling was conducted to remedy these limitations. The results indicated that affect labeling, relative to other forms of encoding, diminished the response of the amygdala and other limbic regions to negative emotional images. Additionally, affect labeling produced increased activity in a single brain region, right ventrolateral prefrontal cortex (RVLPFC). Finally, RVLPFC and amygdala activity during affect labeling were inversely correlated, a relationship that was mediated by activity in medial prefrontal cortex (MPFC). These results suggest that affect labeling may diminish emotional reactivity along a pathway from RVLPFC to MPFC to the amygdala.
authors.affiliation: University of California, Los Angeles, CA 90095-1563, USA. lieber@ucla.edu
authors.forename: Matthew D
authors.initials: MD
authors.lastname: Lieberman
authors.forename: Naomi I
authors.initials: NI
authors.lastname: Eisenberger
authors.forename: Molly J
authors.initials: MJ
authors.lastname: Crockett
authors.forename: Sabrina M
authors.initials: SM
authors.lastname: Tom
authors.forename: Jennifer H
authors.initials: JH
authors.lastname: Pfeifer
authors.forename: Baldwin M
authors.initials: BM
authors.lastname: Way
mesh_terms: D000293:Adolescent; D000328:Adult; D000339:Affect / Q000502:physiology*; D000679:Amygdala / Q000033:anatomy & histology / Q000502:physiology*; D000704:Analysis of Variance; D001931:Brain Mapping / Q000379:methods; D003463:Cues; D004644:Emotions / Q000502:physiology*; D005149:Facial Expression; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D010775:Photic Stimulation / Q000379:methods; D017397:Prefrontal Cortex / Q000033:anatomy & histology; D017678:Sex Distribution; D013647:Task Performance and Analysis; D014796:Visual Perception / Q000502:physiology