Preparation of uniform prednisolone microcrystals by a controlled microprecipitation method.
Prednisolone (PDL) microcrystals were successfully prepared by a controlled microprecipitation method. The characterization of PDL microcrystals by SEM and PSD indicated that the hexagonal and tetragonal PDL microcrystals with an average particle size of 1.60 and 1.46 microm could be prepared under a stirring speed of 10,000 rpm at 14 and 4 degrees C, respectively. The morphology and the particle size of PDL could be well controlled, from 1.60 to 6.12 microm for hexagonal microcrystals and 1.46 to 3.90 microm for tetragonal ones, by altering the operating parameters such as temperature, stirring speed and stabilizers. The XRD, TGA-DSC, FT-IR and physical stability studies demonstrated that the as-prepared hexagonal and tetragonal PDL microcrystals with the same pseudopolymorphic form were much more stable in water than the commercial micronized PDL with another crystal form. The dissolution tests showed that the hexagonal and tetragonal PDL microcrystals exhibited significantly enhanced dissolution property when compared to commercial micronized PDL.
Li
Xiang-Shan
XS
Sin-China Nano Technology Center, Key Lab for Nanomaterials, Ministry of Education, Beijing University of Chemical Technology, Beijing 100029, PR China.
Wang
Jie-Xin
JX
Shen
Zhi-Gang
ZG
Zhang
Peng-Yuan
PY
Chen
Jian-Feng
JF
Yun
Jimmy
J
D000893:Anti-Inflammatory Agents / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning; D011232:Chemical Precipitation; D002626:Chemistry, Pharmaceutical; D003460:Crystallization; D004355:Drug Stability; D008832:Microchemistry; D008855:Microscopy, Electron, Scanning; D010316:Particle Size; D011239:Prednisolone / Q000737:chemistry*; D012995:Solubility; D012997:Solvents; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties; D013696:Temperature; D013818:Thermogravimetry; D014961:X-Ray Diffraction
D000893:Anti-Inflammatory Agents; D012997:Solvents; D011239:Prednisolone