title: Radioguided localization of clinically occult breast lesions (ROLL): a pilot study.
abstract: Management of nonpalpable breast lesions requiring pathologic diagnosis has been with wire localization during the last few decades. Recently, radioguided localization (ROLL) became an alternative for this type of lesions. The objective of the present study was to evaluate the feasibility of this technique in a tertiary referral center in Mexico City. Consecutive patients requiring pathologic diagnosis from a nonpalpable breast lesion were included in the present study. On the same day of operation, all patients were injected with particles of human serum albumin. Localization of the lesion was performed in the operation theater with the aid of a hand-held gamma-probe. All lesions were identified in a control x-ray of the surgical specimen. Demographic, clinical, surgical and pathologic data were recorded. Forty patients with a mean age of 56.8 +/- 7.8 years were included. In 39 of the 40 patients (97.5%) the "hot spot" was identified easily. In all patients, the area of maximum radioactivity corresponded to the site of the lesion. Imaging confirmation of the lesion in the surgical specimen was done during the first excision in 37 patients (92.5%). In the remaining cases (7.5%), a wider excision was performed during the same procedure, finding the suspected lesion in all cases. Diagnosis of cancer was made in seven patients, (17.5%). There were no significant surgical complications. Our data suggest that ROLL offer a simple and reliable method to localize occult breast lesions, allowing complete removal of the lesion in 100% of the patients. Because of the small quantity of radioactivity, the procedure is safe for both patients and the medical staff, producing less discomfort in patients than wire localization.
authors.affiliation: Department of Surgery, Section of Surgical Oncology, National Institute of Medical Sciences and Nutrition Salvador Zubirán, Mexico City, Mexico. herimd@hotmail.com
authors.forename: Heriberto
authors.initials: H
authors.lastname: Medina-Franco
authors.forename: Leonardo
authors.initials: L
authors.lastname: Abarca-Pérez
authors.forename: José L
authors.initials: JL
authors.lastname: Ulloa-Gómez
authors.forename: Cecilia
authors.initials: C
authors.lastname: Romero
mesh_terms: D001941:Breast Diseases / Q000000981:diagnostic imaging* / Q000601:surgery*; D001943:Breast Neoplasms / Q000000981:diagnostic imaging / Q000601:surgery*; D003949:Diagnostic Techniques, Surgical; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008327:Mammography; D008875:Middle Aged; D010865:Pilot Projects; D015203:Reproducibility of Results; D013668:Technetium Tc 99m Aggregated Albumin
chemical_list: D013668:Technetium Tc 99m Aggregated Albumin