[Progressive multifocal leukoencephalopathy in a non-AIDS patient: high efficiency of combined cytarabine and cidofovir].
BACKGROUND
Progressive multifocal leukoencephalopathy (PML) is an opportunistic infection of the central nervous system, occurring in immunocompromised patients. Treatment, not codified to date, is more often inefficient with a rapid and fatal deterioration.


METHODS
A 48-year-old woman, treated with immunosuppressant agents for systemic lupus, presented with PML mimicking neurolupus flare. A complete remission was obtained with cytarabine and cidofovir.


CONCLUSIONS
Combined cytarabine and cidofovir appears a promising therapeutic option in PML associated with autoimmune systemic disorders.
Terrier
B
B
Service de Néphrologie Adultes, Hôpital Necker-Enfants-malades, Assistance publique-Hôpitaux de Paris (APHP), Université Paris-Descartes, 75015 Paris, France.
Hummel
A
A
Fakhouri
F
F
Jablonski
M
M
Hügle
T
T
Gasnault
J
J
Sanson
M
M
Martinez
F
F
D000998:Antiviral Agents / Q000627:therapeutic use*; D000077404:Cidofovir; D003561:Cytarabine / Q000627:therapeutic use*; D003596:Cytosine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D007968:Leukoencephalopathy, Progressive Multifocal / Q000175:diagnosis* / Q000188:drug therapy*; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy; D008875:Middle Aged; D009894:Opportunistic Infections / Q000188:drug therapy / Q000821:virology; D063065:Organophosphonates / Q000627:therapeutic use*; D016896:Treatment Outcome
D000998:Antiviral Agents; D007166:Immunosuppressive Agents; D063065:Organophosphonates; D003561:Cytarabine; D003596:Cytosine; D000077404:Cidofovir