title: [Effect of saikosaponin alpha on experimental epilepsy in rats].
abstract: OBJECTIVE
  To investigate the effect of saikosaponin alpha (SSalpha) on experimental epilepsy in rats.
  
  
  METHODS
  Acute epileptic seizure was induced by pentylenetetrazole (PTZ) in rats, and the seizure incubation period and the number of rats with tetanic convulsion were recorded to study the antiepileptic effect of SSalpha.
  
  
  RESULTS
  After treatment with SSalpha, the incubation period of PTZ-induced seizure was significantly prolonged (P<0.01), and the rate of tetanic convulsion was significantly reduced (P<0.05).
  
  
  CONCLUSIONS
  SSalpha can inhibit epileptic seizure induced by PTZ.
authors.affiliation: Department of Traditional Chinese Medicine, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. lcztcm@126.com
authors.forename: Chang-zheng
authors.initials: CZ
authors.lastname: Li
authors.forename: Wei
authors.initials: W
authors.lastname: Xie
authors.forename: Yong
authors.initials: Y
authors.lastname: Bao
authors.forename: Ye
authors.initials: Y
authors.lastname: Zhou
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D000927:Anticonvulsants / Q000494:pharmacology; D004827:Epilepsy / Q000139:chemically induced / Q000517:prevention & control*; D005260:Female; D008297:Male; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D010433:Pentylenetetrazole; D051381:Rats; D017207:Rats, Sprague-Dawley; D012503:Saponins / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000927:Anticonvulsants; D012503:Saponins; D009828:Oleanolic Acid; C025759:saikosaponin D; D010433:Pentylenetetrazole