Effect of left ventricular shape alteration on contractility and function.
We have investigated the effect of left ventricular (LV) shape on contractility and ejection function. In this study, a new contractility index is developed in terms of the wall stress (sigma*, normalized with respect to LV pressure) by means of an LV ellipsoidal model. Using cine-ventriculography data, the LV ellipsoidal model (LVEM) major (B) and minor axes (A) are derived for the entire cardiac cycle. Thereafter, a new contractility index (CONT1) is derived as dsigma*/dt, incorporating the LV ellipsoidal shape factor. Also, another contractility index (CONT2) was developed in terms of the generated sigma* at the start of ejection phase, and maximized with respect to B/Ashape parameter, to obtain the optimal value of B/Aover the physiological ranges of the ratio of myocardial volume and LV volume. The in vivovalue of B/Aat the start of ejection is compared with this optimal value, and the LV contractility is evaluated in terms of the proximity of the in vivo B/Ato the optimal B/A. The results indicate that a non-optimal less-ellipsoidal shape (or more spherical) is associated with decreased contractility (and poor systolic function) of the LV, associated with a failing heart.
Zhong
L
L
School of Mechanical and Production Engineering, College of Engineering, Nanyang Technological University, Nanyang Avenue, Republic of Singapore.
Ghista
D N
DN
Ng
E Y K
EY
Lim
S T
ST
Chua
T S J
TS
Lee
C N
CN
D000465:Algorithms; D001794:Blood Pressure / Q000502:physiology; D003327:Coronary Disease / Q000503:physiopathology; D006321:Heart / Q000033:anatomy & histology / Q000502:physiology* / Q000503:physiopathology; D006801:Humans; D008954:Models, Biological; D009200:Myocardial Contraction / Q000502:physiology*; D013314:Stress, Mechanical; D016277:Ventricular Function, Left / Q000502:physiology*