title: Statin enhancement of collateralization in acute stroke.
abstract: Collateral circulation influences cerebral infarction occurrence and size. Statins may improve ischemic stroke outcomes. We evaluated the relationship between prestroke statin use and pretreatment angiographic collateral grade among acute ischemic stroke patients presenting with occlusion of a major cerebral artery. After adjusting for covariates, the statin-treated group had significantly higher collateral scores than non-statin users, suggesting an association between statin use and better collateralization during acute stroke.
authors.affiliation: Department of Neurology, UCLA Medical Center, Los Angeles, CA 90095, USA. ovibes@mednet.ucla.edu
authors.forename: B
authors.initials: B
authors.lastname: Ovbiagele
authors.forename: J L
authors.initials: JL
authors.lastname: Saver
authors.forename: S
authors.initials: S
authors.lastname: Starkman
authors.forename: D
authors.initials: D
authors.lastname: Kim
authors.forename: L K
authors.initials: LK
authors.lastname: Ali
authors.forename: R
authors.initials: R
authors.lastname: Jahan
authors.forename: G R
authors.initials: GR
authors.lastname: Duckwiler
authors.forename: F
authors.initials: F
authors.lastname: Viñuela
authors.forename: S
authors.initials: S
authors.lastname: Pineda
authors.forename: D S
authors.initials: DS
authors.lastname: Liebeskind
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D002545:Brain Ischemia / Q000188:drug therapy* / Q000503:physiopathology; D002536:Cerebral Arteries / Q000187:drug effects* / Q000503:physiopathology; D002560:Cerebrovascular Circulation / Q000187:drug effects / Q000502:physiology; D003097:Collateral Circulation / Q000187:drug effects*; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D006973:Hypertension / Q000150:complications / Q000503:physiopathology; D008297:Male; D008833:Microcirculation / Q000187:drug effects* / Q000503:physiopathology; D008875:Middle Aged; D011446:Prospective Studies; D020127:Recovery of Function / Q000187:drug effects / Q000502:physiology; D012189:Retrospective Studies; D020521:Stroke / Q000188:drug therapy* / Q000503:physiopathology; D016896:Treatment Outcome
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors