Seroreactivity to Pf 155/RESA in two malaria endemic ecological zones in Southern Ghana.
Seroepidemiological data are becoming important tools in determining transmission patterns of malaria. We have undertaken a study in 2 different ecological zones in southern Ghana during both the dry and wet seasons. Virtually all the subjects studied were positive to the crude parasite antigen (92%), with majority showing high titres in both areas. Whilst there was a statistical difference in Geometrical Mean Titre (GMT) between the two areas, seasonal variation was not seen. Antibody levels to the Pfl55/RESA and its repeat pepetide (EENV)6 increased progres notsively with age in endemic areas. These findings have relevance in determining malaria transmission in endemic areas.
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'Noguchi Memorial Institute for Medical Research, Box 25, Legon Ghana. Telephone: (233) 21 500374; Fax: (233) 21 502 182; Email: noguchi@ncs.com.gh.
Afari
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Nkrumah
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Dunyoh
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Perlmann
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