[(Bisphosphine) Ru(II) diamine] complexes in asymmetric hydrogenation: expanding the scope of the diamine ligand.
[(Bisphosphine) RuCl 2 (1,2-diamine)] complexes are powerful catalysts in the asymmetric hydrogenation of unfunctionalized ketones. We sought to expand the scope and applicability of these complexes by exploring changes to the diamine structural motif. Via introduction of 1,3- and 1,4-diamines, the catalytic activity was significantly altered such that new classes of ketones could be considered for [(bisphosphine) RuCl 2 (diamine)] asymmetric hydrogenation.
Hems
William P
WP
Johnson Matthey Catalysis and Chiral Technologies, 28 Cambridge Science Park, Milton Road, Cambridge CB4 0FP, United Kingdom. william.hems@matthey.com
Groarke
Michelle
M
Zanotti-Gerosa
Antonio
A
Grasa
Gabriela A
GA