title: Impact of human metapneumovirus and respiratory syncytial virus co-infection in severe bronchiolitis.
abstract: We have previously shown high rates of co-infection with Respiratory Syncytial Virus (RSV) and human Metapneumovirus (hMPV) in infants with severe bronchiolitis at our institution in 2000-2002, and that co-infection was associated with increased disease severity. In this study, we have attempted to identify differences in intubated infants with severe RSV infection with and without hMPV co-infection. Here we show that RSV+/hMPV+ were clinically symptomatic for longer than RSV+/hMPV- infants, but that no differences in airway total cell concentration, differential cell count or cytokine/chemokine concentrations were detectable.
authors.affiliation: Institute of Child Health, Royal Liverpool Children's Hospital, Eaton Rd, Liverpool L12 2AP, United Kingdom. mcnamp@liv.ac.uk
authors.forename: Paul S
authors.initials: PS
authors.lastname: McNamara
authors.forename: Brian F
authors.initials: BF
authors.lastname: Flanagan
authors.forename: Rosalind L
authors.initials: RL
authors.lastname: Smyth
authors.forename: C Anthony
authors.initials: CA
authors.lastname: Hart
mesh_terms: D001988:Bronchiolitis / Q000150:complications*; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry / Q000166:cytology; D016207:Cytokines / Q000032:analysis; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D018184:Paramyxoviridae Infections / Q000150:complications*; D018357:Respiratory Syncytial Virus Infections / Q000150:complications*
chemical_list: D016207:Cytokines