[Angiotensin-1 converting enzyme insertion/deletion gene polymorphism in a Mexican population with diabetic nephropathy].
OBJECTIVE
Diabetic nephropathy is a polygenic and multifactorial disease. Studies of familial clustering and genetic predisposition suggest that genetic factors are involved. Among candidate genes, the coding for angiotensin-converting enzyme (ACE) polymorphism has been described. Our objective was to investigate the association ACE gene insertion/deletion (I/D) polymorphism with the development of diabetic nephropathy in a Mexican population.


METHODS
In a cross-sectional study, we evaluated 204 patients with type 2 diabetes: 43 with incipient diabetic nephropathy, 45 with established diabetic nephropathy and 116 without diabetic nephropathy. Diabetic nephropathy was defined according the American Diabetes Association criteria. The ACE I/D gene polymorphism was detected by polymerase chain reaction.


RESULTS
Patients with type 2 diabetes with both incipient diabetic nephropathy and established diabetic nephropathy significantly differed from controls with respect to variables that determined kidney damage (P<.0001) and serum lipids ( P<.01). The genotype DD was strongly associated with the development of incipient diabetic nephropathy (odds ratio [OR] adjusted = 2.83; 95% confidence interval, 1.74-4.59; P<.0001) and established diabetic nephropathy (OR adjusted = 2.95; 95% CI, 1.83-4.73; P<.0001).


CONCLUSIONS
The ACE DD genotype is associated with the development of incipient diabetic nephropathy and established diabetic nephropathy in a Mexican population.
Ortega-Pierres
Luz Elena
LE
Departamento de Posgrado, Facultad de Ciencias Médicas y Biológicas Dr. Ignacio Chávez, Universidad Michoacana de San Nicolás de Hidalgo (UMSNH), Morelia, Michoacán, México.
Gómez García
Anel
A
Rodríguez-Ayala
Ernesto
E
Figueroa-Núñez
Benigno
B
Farias-Rodríguez
Víctor Manuel
VM
Higareda-Mendoza
Ana Edith
AE
Pardo-Galván
Marco Aurelio
MA
Cortés-García
Juan Carlos
JC
López-Meza
Joel Edmundo
JE
Alvarez-Aguilar
Cleto
C
D003928:Diabetic Nephropathies / Q000235:genetics*; D005260:Female; D006801:Humans; D054643:INDEL Mutation; D008297:Male; D008800:Mexico; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic
C488034:ACE protein, human; D007703:Peptidyl-Dipeptidase A