title: Lesion T(2) relaxation times and volumes predict the response of malignant breast lesions to neoadjuvant chemotherapy.
abstract: The aim of this study was to investigate the utility of the water T(2) values of malignant breast lesions in predicting response after the first and second cycles of neoadjuvant chemotherapy (NAC), both alone and in combination with lesion volumes. Thirty-five patients were scanned before the commencement of chemotherapy and again after the first, second and final treatment cycles. Two methods of obtaining lesion T(2) were used: imaging, where a series of T(2)-weighted images was acquired (T(R)/T(E)=1000/30, 60, 90 and 120 ms), and spectroscopy, where the T(2) value of unsuppressed water signal was determined with a multiecho sequence (T(R)=1.5 s; initial T(E)=35 ms; 64 steps of 2.5 ms; 2 unsuppressed acquisitions per T(E)). Lesion volumes were computed from contrast-enhanced 3D fat-suppressed images. The study found that, using the imaging method of obtaining T(2), the ratio of the product of lesion T(2) and volume after the second cycle of NAC to pretreatment value is a good predictor of ultimate lesion response, defined as a > or =65% reduction in tumor volume after the final treatment cycle, with positive and negative predictive values of 95.5% and 84.6%, respectively.
authors.affiliation: Centre for Magnetic Resonance Investigations, University of Hull, Hull Royal Infirmary, HU3 2JZ, Hull, UK.
authors.forename: P Clara
authors.initials: PC
authors.lastname: Tan
authors.forename: Martin D
authors.initials: MD
authors.lastname: Pickles
authors.forename: Martin
authors.initials: M
authors.lastname: Lowry
authors.forename: David J
authors.initials: DJ
authors.lastname: Manton
authors.forename: Lindsay W
authors.initials: LW
authors.lastname: Turnbull
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D011237:Predictive Value of Tests; D012372:ROC Curve; D016896:Treatment Outcome