Solid phase extraction of phosphorus-containing amino acid-type herbicides and their metabolites from human blood with titania for determination by capillary electrophoresis.
Phosphorus-containing amino acid-type herbicides (PAAHs) and their metabolites in human plasma and whole blood were extracted with titania and determined by capillary electrophoresis (CE). The recoveries of glyphosate (GLYP), aminomethylphosphonic acid (AMPA), gluphosinate (GLUF), and 3-methylphosphonico-propionic acid (MPPA) from human plasma were 84.6, 76.8, 90.4, and 89.6%, respectively. The recoveries of GLYP, AMPA, GLUF, and MPPA from whole blood were 79.6, 84.4, 36.9, and 31.8%, respectively. The low recoveries of GLUF and MPPA from whole blood were improved by the dilution of whole blood with water to 4-fold.
Ishiwata
Tetsuya
T
Scientific Investigation Laboratory, Ibaraki Prefectural Police Headquarters, Japan.
Ishijima
Chiho
C
Ohashi
Akira
A
Okada
Haruki
H
Ohashi
Kousaburo
K
D000613:Aminobutyrates / Q000097:blood / Q000737:chemistry / Q000378:metabolism; D002138:Calibration; D019075:Electrophoresis, Capillary / Q000379:methods*; D004791:Enzyme Inhibitors / Q000097:blood / Q000737:chemistry / Q000378:metabolism; D005998:Glycine / Q000031:analogs & derivatives / Q000097:blood / Q000737:chemistry / Q000378:metabolism; D006540:Herbicides / Q000097:blood* / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D007555:Isoxazoles; D015394:Molecular Structure; D063065:Organophosphonates / Q000097:blood / Q000737:chemistry / Q000378:metabolism; D011422:Propionates / Q000097:blood / Q000737:chemistry / Q000378:metabolism; D015203:Reproducibility of Results; D052616:Solid Phase Extraction / Q000379:methods*; D013777:Tetrazoles; D014025:Titanium / Q000737:chemistry*; D000097797:Glyphosate
D000613:Aminobutyrates; D004791:Enzyme Inhibitors; D005998:Glycine; D006540:Herbicides; D007555:Isoxazoles; D063065:Organophosphonates; D011422:Propionates; D013777:Tetrazoles; D014025:Titanium; D000097797:Glyphosate; C417734:AE F061517; C009495:titanium dioxide; C003121:phosphinothricin; C418233:2-amino-3-(3-hydrox-5(2-methyl-2H-tetrazol-5-yl)isoxazol-4-yl)propionic acid