Chromatin dynamics and the preservation of genetic information.
The integrity of the genome is frequently challenged by double-strand breaks in the DNA. Defects in the cellular response to double-strand breaks are a major cause of cancer and other age-related pathologies; therefore, much effort has been directed at understanding the enzymatic mechanisms involved in recognizing, signalling and repairing double-strand breaks. Recent work indicates that chromatin - the fibres into which DNA is packaged with a proteinaceous structural polymer - has an important role in initiating, propagating and terminating this cellular response to DNA damage.
Downs
Jessica A
JA
MRC Genome Damage and Stability Centre, University of Sussex, Brighton BN1 9RQ, UK. j.a.downs@sussex.ac.uk
Nussenzweig
Michel C
MC
Nussenzweig
André
A
D002843:Chromatin / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D053903:DNA Breaks, Double-Stranded; D004260:DNA Repair; D006657:Histones / Q000378:metabolism; D009707:Nucleosomes / Q000737:chemistry / Q000235:genetics / Q000378:metabolism
D002843:Chromatin; D006657:Histones; D009707:Nucleosomes