Association of ICAM3 genetic variant with severe acute respiratory syndrome.
Genetic polymorphisms have been demonstrated to be associated with vulnerability to human infection. ICAM3, an intercellular adhesion molecule important for T cell activation, and FCER2 (CD23), an immune response gene, both located on chromosome 19p13.3, were investigated for host genetic susceptibility and association with clinical outcome. A case-control study based on 817 patients with confirmed severe acute respiratory syndrome (SARS), 307 health care worker control subjects, 290 outpatient control subjects, and 309 household control subjects unaffected by SARS from Hong Kong was conducted to test for genetic association. No significant association to susceptibility to SARS infection caused by the novel coronavirus (SARS-CoV) was found for the FCER2 and the ICAM3 single nucleotide polymorphisms. However, patients with SARS homozygous for ICAM3 Gly143 showed significant association with higher lactate dehydrogenase levels (P=.0067; odds ratio [OR], 4.31 [95% confidence interval {CI}, 1.37-13.56]) and lower total white blood cell counts (P=.022; OR, 0.30 [95% CI, 0.10-0.89]) on admission. These findings support the role of ICAM3 in the immunopathogenesis of SARS.
Chan
Kelvin Y K
KY
Department of Pathology, University of Hong Kong, Queen Mary Hospital, Pokfulam Rd, Hong Kong.
Ching
Johannes C Y
JC
Xu
M S
MS
Cheung
Annie N Y
AN
Yip
Shea-Ping
SP
Yam
Loretta Y C
LY
Lai
Sik-To
ST
Chu
Chung-Ming
CM
Wong
Andrew T Y
AT
Song
You-Qiang
YQ
Huang
Fang-Ping
FP
Liu
Wei
W
Chung
P H
PH
Leung
G M
GM
Chow
Eudora Y D
EY
Chan
Eric Y T
EY
Chan
Jane C K
JC
Ngan
Hextan Y S
HY
Tam
Paul
P
Chan
Li-Chong
LC
Sham
Pak
P
Chan
Vera S F
VS
Peiris
Malik
M
Lin
Steve C L
SC
Khoo
Ui-Soon
US
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015703:Antigens, CD / Q000235:genetics*; D016022:Case-Control Studies; D015815:Cell Adhesion Molecules / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood*; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D045169:Severe Acute Respiratory Syndrome / Q000235:genetics* / Q000503:physiopathology
D015703:Antigens, CD; D015815:Cell Adhesion Molecules; C483616:ICAM3 protein, human; D007770:L-Lactate Dehydrogenase