title: Assessing glycemia in type 1 diabetic patients using a microdialysis system for continuous glucose monitoring.
abstract: BACKGROUND
  Continuous glucose monitoring systems can monitor moment-to-moment changes in blood glucose concentration, which cannot be detected by intermittent self-monitoring. Continuing monitoring systems may lead to improved glycemic control. We evaluated a microdialysis technique for improving glycemic control in type 1 diabetes patients treated by different means of basal insulin substitution.
  
  
  METHODS
  Fifty-two type 1 diabetic patients on twice daily NPH and pre-meal aspart insulin were randomized in two groups: the continuation of NPH (n=26) (group 1) or once daily glargine (n=26) (group 2). 48-hour GlucoDay registrations were started at the beginning and after 4 months.
  
  
  RESULTS
  At baseline, time spent in the euglycemic range (glucose between 3.9 and 8.0 mmol/L) was 37.96+/-6.81% for the NPH group and 35.83+/-6.24% for the glargine group. At endpoint, time in the euglycemic range increased in both groups (51.02+/-7.22% and 57.29+/-10.27%, P<0.001 vs. before treatment for both groups). Time spent in the hypoglycemic range (glucose <3.9 mmol/L) was 9.+/-2.57% for the first group and 10.24+/-3.55% for the second group at baseline. At endpoint, time in the hypoglycemic range decreased in both groups (8.00+/-2.13% and 6.59+/-2.04%, P<0.001 vs. before treatment for both groups).
  
  
  CONCLUSIONS
  The analysis of the GlucoDay data gave us information about glycemia other than HbA1c and self-monitoring of blood glucose, such us a peakless activity profile and the lower percentage of time spent in the hypoglycemic range in the glargine-treated group.
authors.affiliation: Department of Internal Medicine-Endocrinology Unit, Clinical Hospital Split, Soltanska, Split, Croatia.
authors.forename: Maja
authors.initials: M
authors.lastname: Radman
authors.forename: Dubravka
authors.initials: D
authors.lastname: Jurisić
authors.forename: Dragan
authors.initials: D
authors.lastname: Ljutić
authors.forename: Romana
authors.initials: R
authors.lastname: Jerković
authors.forename: Natasa
authors.initials: N
authors.lastname: Kovacić
authors.forename: Izet Salih
authors.initials: IS
authors.lastname: Hozo
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000032:analysis*; D015190:Blood Glucose Self-Monitoring; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D017551:Microdialysis
chemical_list: D001786:Blood Glucose