Dietary restriction modulates alpha-synuclein expression in the aging rat cortex and hippocampus.
Dietary restriction (DR) is one of the promising environmental interventions known to attenuate aging and decrease risk of age-related neurodegenerative disorders. The aim of this study was to assess the effects of DR on expression of alpha-synuclein, a presynaptic protein involved in pathogenesis of Parkinson's and some other neurodegenerative diseases, in the cortex and hippocampus of adult, middle-aged, late middle-aged, and aged rats. Using Real Time RT-PCR, the authors report that aging regulates the expression of alpha-synuclein in a tissue-specific manner and that long-term DR reverts the late age-related changes of alpha-synuclein expression.
Mladenovic
Aleksandra
A
Institute for Biological Research, Belgrade, Serbia.
Perovic
Milka
M
Tanic
Nikola
N
Petanceska
Suzana
S
Ruzdijic
Sabera
S
Kanazir
Selma
S
D000367:Age Factors; D000375:Aging; D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism*; D018753:Diet, Protein-Restricted / Q000379:methods*; D005786:Gene Expression Regulation / Q000502:physiology; D006624:Hippocampus / Q000378:metabolism*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D051844:alpha-Synuclein / Q000378:metabolism*
D051844:alpha-Synuclein