Adverse events following booster doses of diphtheria-tetanus-inactivated poliovirus and acellular pertussis vaccines for 4-year-old children in The Netherlands.
The aim of the study was to assess the incidence and severity of local reactions and systemic events among 4-year-old children receiving a fifth dose of diphtheria-tetanus-inactivated poliovirus (dT-IPV) and acellular pertussis (aP) vaccines. Of 810 children, 483 had no adverse events following immunization. Of the reported local reactions of 281 children, pain was the most frequent (n=246). Eighty-one children developed redness, and 54, swelling. Pain, reduced use of the arm, redness, and swelling occurred significantly more often at the dT-IPV injection site than at the aP injection site (p<0.05). Local reactions were mainly mild and transient. Among the 104 reported systemic events, fever was the most frequent (n=42). In general, the vaccinations for the 4-year-olds are well tolerated.
Bults
M
M
Safety, Surveillance, and Consultation of the National Immunization Programme, Epidemiology and Surveillance Unit, National Institute for Public Health and the Environment, The Netherlands. marloes.bults@rivm.nl
Kemmeren
J M
JM
van der Maas
N A T
NA
D002648:Child; D002675:Child, Preschool; D004168:Diphtheria Toxoid / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007117:Immunization, Secondary / Q000009:adverse effects*; D015994:Incidence; D007223:Infant; D008297:Male; D009426:Netherlands; D010567:Pertussis Vaccine / Q000009:adverse effects*; D011054:Poliovirus Vaccine, Inactivated / Q000009:adverse effects*; D013745:Tetanus Toxoid / Q000009:adverse effects*; D022282:Vaccines, Acellular / Q000009:adverse effects; D017778:Vaccines, Combined / Q000009:adverse effects
D004168:Diphtheria Toxoid; D010567:Pertussis Vaccine; D011054:Poliovirus Vaccine, Inactivated; D013745:Tetanus Toxoid; D022282:Vaccines, Acellular; D017778:Vaccines, Combined