[The influence of local and remote myocardial preconditioning on the incidence and severity of experimentally induced ischemic tachyarrhythmias].
Ischemic preconditioning (IPC) is one of the most effective means of myocardial protection against ischemic injury and involves two main types, local and remote. The aim of the present study was to investigate antiarrhythmic effects of local and remote IPC against early ischemic ventricular tachyarrhythmias (VTA) in a rat model of myocardial infarction. In contrast to local mode, remote IPC did not decrease the incidence and severity of ischemic VTA. The potential mechanisms of the antiarrhythmic effect of local IPC are discussed in the article together with prospects of clinical IPC application.
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D000818:Animals; D015994:Incidence; D019157:Ischemic Preconditioning, Myocardial / Q000379:methods*; D008297:Male; D023421:Models, Animal; D017202:Myocardial Ischemia / Q000150:complications*; D051381:Rats; D017208:Rats, Wistar; D012720:Severity of Illness Index; D013610:Tachycardia / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology*