Long-term outcome in children after Henoch-Schonlein purpura nephritis.
This study investigated predictors of renal survival in children with Henoch-Schönlein purpura glomerulonephritis. Records of patients with Henoch-Schönlein purpura glomerulonephritis evaluated at our center, from 1953-1990, were reviewed. Data were abstracted from records of patients seen within 5 years. Others were mailed a questionnaire or contacted by telephone. Primary outcome measures were renal survival and presence of urinary abnormalities or hypertension. Of the 65 eligible patients with Henoch Schönlein purpura glomerulonephritis, follow-up data was obtainable for 81.5%. The median follow-up was 20 years. At last follow-up, 66% of patients had normal renal function and urinalyses, and 21% had progressed to end-stage renal disease. The only factor associated with the development of end-stage renal disease was the use of cytotoxic agents. There are no features at initial presentation that identify children at risk of disease progression. Close follow-up of all children with Henoch Schönlein purpura glomerulonephritis is warranted.
Butani
Lavjay
L
Pediatric Nephrology, University of California, Davis Medical Center, Sacramento, California 95817, USA. lavjay.butani@ ucdmc.ucdavis.edu
Morgenstern
Bruce Z
BZ
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D018450:Disease Progression; D005260:Female; D005921:Glomerulonephritis / Q000209:etiology* / Q000401:mortality / Q000628:therapy; D006801:Humans; D011695:IgA Vasculitis / Q000150:complications*; D007223:Infant; D053208:Kaplan-Meier Estimate; D007676:Kidney Failure, Chronic / Q000175:diagnosis / Q000209:etiology* / Q000401:mortality; D008137:Longitudinal Studies; D008297:Male; D011379:Prognosis; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome