title: [Intake of an iron-supplemented milk formula as a preventive measure to avoid low iron status in 1-3 year-olds].
abstract: OBJECTIVE
  Low iron status is a well known risk factor for iron deficiency anemia in infants and young children. The aim of the present study was to evaluate the influence of an iron-fortified toddler formula on iron status in 1-3 year-olds.
  
  
  METHODS
  Thirty-three healthy infants and young children were assigned to two groups that received 500 mL/day of and iron-fortified toddler formula or 500 mL/day of unmodified cow's milk for 4 months. Allocation was random and double-blind. Daily dietary intake was calculated by dietary evaluation, and iron nutritional status was assessed (hemoglobin, hematocrit, mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, serum iron, ferritin, and transferrin).
  
  
  RESULTS
  At enrollment, no anemia was found in either group, although hemoglobin concentration and hematocrit were significantly lower in the toddler formula group than in the unmodified cow's milk group. However, these differences disappeared at the end of the intervention period. After 4 months, the toddler formula group showed significantly higher serum ferritin and lower serum transferrin concentrations than the cow's milk group.
  
  
  CONCLUSIONS
  Intake of iron-supplemented toddler formula for 4 months in 1-3 year-olds is more effective in maintaining iron nutritional status than cow's milk.
authors.affiliation: Departmento de Pediatría, Facultad de Medicina, Universidad de Granada, España. jmaldon@ugr.es
authors.forename: J
authors.initials: J
authors.lastname: Maldonado Lozano
authors.forename: L
authors.initials: L
authors.lastname: Baró
authors.forename: M C
authors.initials: MC
authors.lastname: Ramírez-Tortosa
authors.forename: F
authors.initials: F
authors.lastname: Gil
authors.forename: J
authors.initials: J
authors.lastname: Linde
authors.forename: E
authors.initials: E
authors.lastname: López-Huertas
authors.forename: J J
authors.initials: JJ
authors.lastname: Boza
authors.forename: A
authors.initials: A
authors.lastname: Gil
mesh_terms: D018798:Anemia, Iron-Deficiency / Q000517:prevention & control*; D000818:Animals; D002664:Child Nutritional Physiological Phenomena; D002675:Child, Preschool; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007223:Infant; D041943:Infant Formula; D007227:Infant Nutritional Physiological Phenomena; D007501:Iron / Q000008:administration & dosage / Q000097:blood; D008297:Male; D008892:Milk
chemical_list: D007501:Iron