title: Imaging of cutaneous larva migrans by optical coherence tomography.
abstract: BACKGROUND
  Cutaneous larva migrans is a parasitic skin eruption caused by migration of larvae of various nematodes. Diagnosis of cutaneous larva migrans is currently based on the clinical signs of the creeping eruption. We are investigating a new diagnostic technology called optical coherence tomography (OCT) , which is potentially able to visualize structures in the skin with an 8 microm resolution. This technology could therefore potentially allow rapid, non-invasive, in vivo diagnosis of infestations.
  
  
  METHODS
  Clinical cases of cutaneous larva migrans (n=3) were studied. All patients had a characteristic itching, serpinginous eruption typical of cutaneous larva migrans. The parasites were acquired on beach holidays in Thailand and Malaysia. All skin lesions were imaged by an OCT system developed at Risoe National Laboratory, Denmark.
  
  
  RESULTS
  Two out of three patients showed a round to oval structure (diameter 0.3-0.5mm) in the epidermis, Thus distinct OCT morphology in skin areas affected by cutaneous larva migrans was demonstrated. The larvae were not visualized in any of the patients.
  
  
  CONCLUSIONS
  This study demonstrates that OCT a novel optical imaging technology, can image the larva tunnel in the skin with adequate spatial resolution, but not the larvae itself. OCT has a potential in imaging of skin infestations.
authors.affiliation: Department of Dermatology, University of Copenhagen, Roskilde Hospital, Roskilde, Denmark. rsmmog@ra.dk
authors.forename: Hanan
authors.initials: H
authors.lastname: Morsy
authors.forename: Mette
authors.initials: M
authors.lastname: Mogensen
authors.forename: Jakob
authors.initials: J
authors.lastname: Thomsen
authors.forename: Lars
authors.initials: L
authors.lastname: Thrane
authors.forename: Peter E
authors.initials: PE
authors.lastname: Andersen
authors.forename: Gregor B E
authors.initials: GB
authors.lastname: Jemec
mesh_terms: D000818:Animals; D002648:Child; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007815:Larva Migrans / Q000175:diagnosis* / Q000473:pathology; D008875:Middle Aged; D041623:Tomography, Optical Coherence