Schistosome biology and proteomics: progress and challenges.
The recent availability of schistosomal genome-sequence information allows protein identification in schistosome-derived samples by mass spectrometry (proteomics). Over the last few years, several proteome studies have been performed that addressed important questions in schistosome biology. This review summarizes the applied experimental approaches that have been used so far, it provides an overview of the most important conclusions that can be drawn from the performed studies and finally discusses future challenges in this research area.
van Hellemond
Jaap J
JJ
Department of Medical Microbiology and Infectious Diseases, Erasmus MC, University Medical Center Rotterdam, Dr. Molewaterplein 40, 3015 GD Rotterdam, The Netherlands. j.vanhellemond@erasmusmc.nl
van Balkom
Bas W M
BW
Tielens
Aloysius G M
AG
D000818:Animals; D000947:Antigens, Helminth / Q000502:physiology; D004591:Electrophoresis, Polyacrylamide Gel; D008401:Gas Chromatography-Mass Spectrometry; D020869:Gene Expression Profiling; D049751:Genome, Helminth; D015801:Helminth Proteins / Q000235:genetics / Q000302:isolation & purification* / Q000502:physiology; D006790:Host-Parasite Interactions; D008018:Life Cycle Stages / Q000502:physiology; D008099:Liver / Q000737:chemistry / Q000469:parasitology; D013058:Mass Spectrometry / Q000379:methods; D008565:Membrane Proteins / Q000235:genetics / Q000302:isolation & purification / Q000502:physiology; D020543:Proteome / Q000235:genetics / Q000302:isolation & purification* / Q000502:physiology; D040901:Proteomics / Q000639:trends*; D012547:Schistosoma / Q000235:genetics / Q000254:growth & development / Q000502:physiology*; D012552:Schistosomiasis / Q000469:parasitology; D012727:Sex Characteristics; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
D000947:Antigens, Helminth; D015801:Helminth Proteins; D008565:Membrane Proteins; D020543:Proteome