title: Effects of hyperbaric oxygen therapy on distraction osteogenesis.
abstract: Investigators in the present study explored the effects of hyperbaric oxygen (HBO) therapy on distraction osteogenesis in a rabbit limb-lengthening model. HBO treatment was provided to participants in a small animal pressure chamber once a day during the latent period of distraction osteogenesis at 2.5 absolute atmospheres of pressure. Bone mineral density measurements were obtained through torsional testing. The control group received no HBO treatment. Animals were killed 8 wk postoperatively for biomechanical testing. There was a statistically significant increase in bone mineral density in the HBO group compared with that in the non-HBO group, but no statistically significant differences were observed between biomechanical parameters of the 2 groups. The investigators suggest that these results must be further studied through histologic examination to determine the stepwise effects of HBO during and after collagen synthesis.
authors.affiliation: Department of Orthopaedics and Traumatology, Medical Faculty of Istanbul, University of Istanbul, Istanbul, Turkey.
authors.forename: Levant
authors.initials: L
authors.lastname: Eralp
authors.forename: Korhan
authors.initials: K
authors.lastname: Ozkan
authors.forename: Mehmet
authors.initials: M
authors.lastname: Kocaoglu
authors.forename: Samil
authors.initials: S
authors.lastname: Aktas
authors.forename: Mutlu
authors.initials: M
authors.lastname: Zihni
authors.forename: Mehmet
authors.initials: M
authors.lastname: Türker
authors.forename: Feyza Unlu
authors.initials: FU
authors.lastname: Ozkan
mesh_terms: D000818:Animals; D015519:Bone Density; D006931:Hyperbaric Oxygenation; D019857:Osteogenesis, Distraction; D011817:Rabbits; D013977:Tibia / Q000502:physiology*