Treatability of cefazolin antibiotic formulation effluent with O3 and O3/H2O2 processes.
The effect of applying ozonation and perozonation to antibiotic cefazolin-Na formulation effluents were investigated in this study. Twenty minutes of ozonation at a rate of 1,500 mg/L-h was observed to remove COD by 38%, whereas a COD removal efficiency of 40% was achieved via H2O2 enhanced ozonation (same conditions + 31.25 mM H2O2). Both of the pretreatment alternatives were monitored to elevate the BOD5/COD ratio from 0.01 to 0.08. The initially inert COD was reduced by 38% using ozonation and by 60% employing H2O2 enhanced ozonation. In terms of the lowest achievable effluent COD levels after bio-treatment, ozonation was observed to yield a residual COD of 205 mgL(-1), while a residual COD of 135 mgL(-1) was involved for perozonation. According to the results of acute toxicity on Phaedactylum tricornutum, ozonated and perozonated samples exhibited more toxicity than the untreated effluent after 4 days. The activated sludge inhibition test demonstrated that both of the pretreatment alternatives efficiently eliminated the inhibition of investigated formulation effluent.
Iskender
G
G
Istanbul Technical University, Civil Engineering Faculty, Environmental Engineering Department, 34469, Maslak, Istanbul, Turkey. giskender@ins.itu.edu.tr
Sezer
A
A
Arslan-Alaton
I
I
Germirli Babuna
F
F
Okay
O S
OS
D000900:Anti-Bacterial Agents / Q000737:chemistry*; D002437:Cefazolin / Q000737:chemistry*; D017377:Diatoms / Q000187:drug effects; D006861:Hydrogen Peroxide / Q000737:chemistry*; D010084:Oxidation-Reduction; D010100:Oxygen / Q000032:analysis; D010126:Ozone / Q000737:chemistry*; D023382:Toxicity Tests, Acute; D014865:Waste Disposal, Fluid / Q000379:methods*; D014874:Water Pollutants, Chemical / Q000032:analysis / Q000633:toxicity; D018508:Water Purification / Q000379:methods*
D000900:Anti-Bacterial Agents; D014874:Water Pollutants, Chemical; D010126:Ozone; D006861:Hydrogen Peroxide; D002437:Cefazolin; D010100:Oxygen