title: Surface-imprinted core-shell nanoparticles for sorbent assays.
abstract: In this paper, we present a general protocol for the making of surface-imprinted core-shell nanoparticles via surface reversible addition-fragmentation chain-transfer (RAFT) polymerization using RAFT agent functionalized model silica nanoparticles as the chain-transfer agent. In this protocol, trichloro(4-chloromethylphenyl)silane was immobilized on the surface of SiO2 nanoparticles, forming chloromethylphenyl functionalized silica (silica-Cl). RAFT agent functionalized silica was subsequently produced by substitute reaction of silica-Cl with PhC(S)SMgBr. The grafting copolymerization of 4-vinylpyridine and ethylene glycol dimethacrylate using surface RAFT polymerization and in the presence of 2,4-dichlorophenoxyacetic acid as the template led to the formation of surface-imprinted core-shell nanoparticles. The resulting surface-imprinted core-shell nanoparticles bind the original template 2,4-D with an appreciable selectivity over structurally related compounds. The potential use of the surface-imprinted core-shell nanoparticles as the recognition element in the competitive fluorescent binding assay for 2,4-D was also demonstrated.
authors.affiliation: The Key Lab of Analysis and Detection Technology for Food Safety of the MOE, College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou 350002, P.R. China.
authors.forename: Chun-Hua
authors.initials: CH
authors.lastname: Lu
authors.forename: Wen-Hui
authors.initials: WH
authors.lastname: Zhou
authors.forename: Bing
authors.initials: B
authors.lastname: Han
authors.forename: Huang-Hao
authors.initials: HH
authors.lastname: Yang
authors.forename: Xi
authors.initials: X
authors.lastname: Chen
authors.forename: Xiao-Ru
authors.initials: XR
authors.lastname: Wang
mesh_terms: D008689:Methacrylates / Q000737:chemistry; D053758:Nanoparticles / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry; D011725:Pyridines / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D008689:Methacrylates; D011108:Polymers; D011725:Pyridines; D012822:Silicon Dioxide; C004919:ethylene dimethacrylate; C029351:4-vinylpyridine