title: Development of a database: DACTARI for a radiotoxic element ranking methodology.
abstract: Dosimetric impact studies aim at evaluating potential radiological effects of chronic or acute releases from nuclear facilities. A methodology for ranking radionuclides (RN) in terms of their health-related impact on the human population was first developed at CEA with specific criteria for each RN that could be applied to a variety of situations. It is based, in particular, on applying physico-chemical criteria to the complete RN inventory (present in the release or in the source term) and on applying norms related to radiation protection and chemical toxicology. The initial step consisted in identifying and collecting data necessary to apply the methodology, with reference to a previous database of long-lived radionuclides (LLRN, with half-lives ranging from 30 to 10(14) y) containing 95 radionuclides. The initial results have allowed us to identify missing data and revealed the need to complete the study for both toxic and radiotoxic aspects. This led us to the next step, developing a specific database, DAtabase for Chemical Toxicity and Radiotoxicity Assessment of RadIonuclides (DACTARI), to collect data on chemical toxicity and radiotoxicity, including acute or chronic toxicity, the chemical form of the compounds, the contamination route (ingestion, inhalation), lethal doses, target organs, intestinal and maternal-foetal transfer, drinking water guidelines and the mutagenic and carcinogenic properties.
authors.affiliation: CEA/DEN/DRCP/CETAMA, VRH-Marcoule, BP 17171, 30207 Bagnol-sur-Cèze, France. eric.ansoborlo@cea.fr
authors.forename: E
authors.initials: E
authors.lastname: Ansoborlo
authors.forename: C
authors.initials: C
authors.lastname: Santucci
authors.forename: J P
authors.initials: JP
authors.lastname: Grouiller
authors.forename: L
authors.initials: L
authors.lastname: Boucher
authors.forename: A
authors.initials: A
authors.lastname: Flüry-Herard
authors.forename: F
authors.initials: F
authors.lastname: Menetrier
authors.forename: A
authors.initials: A
authors.lastname: Comte
authors.forename: E
authors.initials: E
authors.lastname: Cook
authors.forename: V
authors.initials: V
authors.lastname: Moulin
mesh_terms: D001681:Biological Assay; D003628:Database Management Systems; D016208:Databases, Factual; D016247:Information Storage and Retrieval / Q000379:methods; D011868:Radioisotopes / Q000145:classification* / Q000506:poisoning*; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D014915:Whole-Body Counting
chemical_list: D011868:Radioisotopes