Two forms of long-term potentiation induced by different compounds.
The purpose of this study was to investigate different forms of long-term potentiation (LTP) induced by different compounds. As shown in results, the influx of calcium via voltage-dependent calcium channels (VDCCs) was responsible for ( - )-clausenamide-induced LTP in hippocampus, while Rg1 induced LTP is mediated by the entry of calcium via N-methyl-d-aspartate glutamate (NMDA) receptor. The findings in the present study provide pharmacological basis for the nootropic mechanisms of these two compounds.
Xu
L
L
Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
Wang
X-Y
XY
Liu
S-L
SL
Zhang
J-T
JT
D000818:Animals; D015220:Calcium Channels / Q000502:physiology*; D036145:Ginsenosides / Q000494:pharmacology*; D007769:Lactams / Q000494:pharmacology*; D017705:Lignans / Q000494:pharmacology*; D017774:Long-Term Potentiation / Q000187:drug effects*; D008297:Male; D009553:Nimodipine / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D016194:Receptors, N-Methyl-D-Aspartate / Q000502:physiology*; D009435:Synaptic Transmission / Q000187:drug effects; D014633:Valine / Q000031:analogs & derivatives / Q000494:pharmacology
D015220:Calcium Channels; D036145:Ginsenosides; D007769:Lactams; D017705:Lignans; D016194:Receptors, N-Methyl-D-Aspartate; C053048:clausenamide; D009553:Nimodipine; C056639:2-amino-5-phosphopentanoic acid; D014633:Valine; C035054:ginsenoside Rg1