[Dose requirements of pentazocine during abdominal surgery in total intravenous anesthesia using propofol].
BACKGROUND
To determine the dose requirements of pentazocine when administered as a single bolus dose in total intravenous anesthesia with propofol for abdominal surgery.


METHODS
One hundred and fifty-six patients scheduled for abdominal surgery were analyzed retrospectively. Patients were classified into three groups according to duration of the operation ; under 120 min (Group 1, n=87) ; 120-240 min (Group 2, n=56) ; over 240 min (Group 3, n=13). Anesthesia was induced with propofol using target controlled infusion method, and was maintained with propofol infusion, pentazocine as a single dose before incision, and intermittent administration of vecuronium with 40% oxygen in air.


RESULTS
Dosage of pentazocine was significantly increased according to length of the operation. The maintenance doses of propofol were not different among the three groups. Awakening time in about 80% of patients in each group was within 15 minutes. There are no severe complications.


CONCLUSIONS
Total intravenous anesthesia with propofol and pentazocine is useful to stabilize hemodynamics and to achieve rapid recovery. For the operation within 120 min, 0.7 mg x kg(-1) of pentazocine is necessary whereas 0.8 mg x kg(-1) of pentazocine is needed in the operation of 120-240 min.
Nonaka
Akihiko
A
Department of Anesthesia, Yamanashi Prefectural Central Hospital, Yamanashi.
Suzuki
Satomi
S
Nagamine
Norimitsu
N
Furuya
Atsushi
A
Abe
Fumiaki
F
D000005:Abdomen / Q000601:surgery*; D000759:Adjuvants, Anesthesia / Q000008:administration & dosage*; D000328:Adult; D000368:Aged; D000701:Analgesics, Opioid / Q000008:administration & dosage*; D000771:Anesthesia, Intravenous; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D010149:Postoperative Pain / Q000517:prevention & control*; D010423:Pentazocine / Q000008:administration & dosage*; D019990:Perioperative Care; D015742:Propofol; D012189:Retrospective Studies; D013997:Time Factors
D000759:Adjuvants, Anesthesia; D000701:Analgesics, Opioid; D010423:Pentazocine; D015742:Propofol