[An unusual case of duplication of the spinal canal].
We describe here a very rare congenital malformation, in which the vertebra Th 9 to 11 were divided into independent bodies and neural arches. The vertebral canal contained the spinal cord, whereas the space between bodies and arches was filled by nerve roots and a central remnant cord, not clearly connected to the main spinal cord. This malformation was considered as related to a fetal alcohol syndrome, with craniofacial and genitourinary abnormalities. The authors analyze, moreover the possible role of abnormal Sonic Hedgehog gene patterning in the pathogeny of this complex malformative sequence.
Ranguelov
N
N
Service de Pédiatrie, C.H.U. de Charleroi.
Sourtzis
S
S
Delpierre
I
I
Christophe
C
C
Louryan
S
S
D000015:Abnormalities, Multiple / Q000209:etiology*; D002675:Child, Preschool; D005260:Female; D063647:Fetal Alcohol Spectrum Disorders / Q000235:genetics; D053823:Hedgehog Proteins / Q000235:genetics; D006801:Humans; D008297:Male; D011247:Pregnancy; D011859:Radiography; D013115:Spinal Canal / Q000002:abnormalities* / Q000000981:diagnostic imaging / Q000254:growth & development; D013116:Spinal Cord / Q000002:abnormalities / Q000000981:diagnostic imaging / Q000254:growth & development
D053823:Hedgehog Proteins