title: Modern trends in ovulation induction.
abstract: Patients with anovulatory infertility, who received treatment at one unit over a four year period, were assessed to determine the pregnancy rate and the incidence of complications while undergoing ovulation induction with gonadotropins. The patients in this group who had further in vitro fertilization (IVF) treatment were followed up, and the outcome in IVF cycles was assessed. Data from a total of 75 patients, who had completed 91 episodes of treatment involving 273 cycles of ovulation induction over a 4-year period in a University-affiliated teaching hospital, was analysed retrospectively. The cumulative pregnancy rate was 34% after three ovulation induction cycles, and was 46% overall. The clinical pregnancy rate per cycle was 15.4%, and per ovulatory cycle was 21%. The multiple pregnancy rate was 12%, and there were no cases of ovarian hyperstimulation syndrome (OHSS). In this group of patients undergoing ovulation induction, the multiple pregnancy rate was 12% and there were no cases of ovarian hyperstimulation syndrome (OHSS). The multiple pregnancy rate was 17%. Our result indicate that anovulatory patients benefit from ovulation induction with gonadotropins prior to IVF treatment.
authors.affiliation: Reproductive Medicine Unit, Clarendon Wing, Leeds General Infirmary, Leeds, UK. svyjayanthi@hotmail.com
authors.forename: S
authors.initials: S
authors.lastname: Vyjayanthi
authors.forename: J
authors.initials: J
authors.lastname: Glanville
authors.forename: E
authors.initials: E
authors.lastname: Yasmin
authors.forename: A H
authors.initials: AH
authors.lastname: Balen
mesh_terms: D000858:Anovulation / Q000188:drug therapy; D005260:Female; D005306:Fertilization / Q000502:physiology; D006062:Gonadotropins / Q000627:therapeutic use; D006801:Humans; D010062:Ovulation Induction / Q000379:methods / Q000639:trends*; D011085:Polycystic Ovary Syndrome / Q000453:epidemiology; D011247:Pregnancy; D011256:Pregnancy Outcome
chemical_list: D006062:Gonadotropins