Leukocyte podosomes sense their way through the endothelium.
Whether leukocytes can transmigrate through endothelial cells, rather than between them, is controversial. In this issue, Carman et al. (2007) demonstrate that lymphocytes can extend podosomes to palpate endothelial cells searching for areas permissive for transcellular diapedesis.
Hidalgo
Andrés
A
Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA.
Frenette
Paul S
PS
D002465:Cell Movement; D004730:Endothelium, Vascular / Q000276:immunology*; D006801:Humans; D007962:Leukocytes / Q000276:immunology*