title: Impact of bispectral index monitoring on propofol administration in patients undergoing cardiopulmonary bypass.
abstract: Propofol anaesthesia using target control infusion during cardiac surgery has become more popular recently. However, without depth of anaesthesia monitoring, the standard target concentration used may be higher than necessary to maintain adequate hypnosis during hypothermic cardiopulmonary bypass. The purpose of this study was to evaluate the effect of bispectral index monitoring on propofol administration during hypothermic cardiopulmonary bypass. After ethics committee approval and written informed consent, 20 New York Heart Association class I-III patients scheduled for elective cardiac surgery requiring hypothermic cardiopulmonary bypass were studied in this prospective randomised controlled trial. In group C, routine anaesthesia was practised, where patients received propofol at target concentration between 1.5 to 2.5 microg/ml during cardiopulmonary bypass. In group B, the target concentration was titrated to a bispectral index value of 40 to 50. Mean arterial pressure and bispectral index were recorded at various time intervals. The use of propofol, phenylephrine, sodium nitroprusside and adrenaline were recorded. The median propofol administration in group B was significantly less than that in group C (2.9 mg/kg/h compared to 6.0 mg/kg/h). The bispectral index value during bypass was significantly lower in group C than in group B, reflecting a deeper state of anaesthesia. There was no difference in the use of inotropes, vasoconstrictors or vasodilators. Bispectral index monitoring enables a 50% reduction in propofol administration at this standard dose during hypothermic cardiopulmonary bypass.
authors.affiliation: Department of Anaesthesia, University of Malaya Medical Centre, Lembah Pantai, Kuala Lumpur 50603, Malaysia. chiuchiawling@yahoo.com.my
authors.forename: C L
authors.initials: CL
authors.lastname: Chiu
authors.forename: G
authors.initials: G
authors.lastname: Ong
authors.forename: A A
authors.initials: AA
authors.lastname: Majid
mesh_terms: D000704:Analysis of Variance; D000771:Anesthesia, Intravenous; D018686:Anesthetics, Intravenous / Q000008:administration & dosage*; D002315:Cardiopulmonary Bypass; D016903:Drug Monitoring / Q000379:methods; D004569:Electroencephalography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015742:Propofol / Q000008:administration & dosage*; D011446:Prospective Studies
chemical_list: D018686:Anesthetics, Intravenous; D015742:Propofol