title: [Clinicopathological study of invasive pulmonary aspergillosis complicated by leukemia].
abstract: OBJECTIVE
  We assessed the clinicopathological features of invasive pulmonary aspergillosis.
  
  
  METHODS
  We conducted chest radiograph-pathologic correlations in 8 cases with invasive pulmonary aspergillosis diagnosed at autopsy.
  
  
  RESULTS
  Subjects were 4 men and 4 women with a mean age of 57.4 years and all having leukemia as an underlying hematological disorder. All had been treated with anticancerous drugs and corticosteroids. Histopathologically, coagulation necrosis with marginal hemorrhage and agranulocytosis were observed in 6 whose initial abnormal shadows in chest X-ray appeared during the neutropenic phase less than 500/microL. In contrast, numerous infiltration of neutrophils and colliquation necrosis at the center of lesions were observed in 2 whose initial abnormal shadows in chest X-ray appeared having more than 500/microL of neutrophils in the peripheral blood.
authors.affiliation: Department of Respiratory Medicine, Toho University School of Medicine.
authors.forename: Keishi
authors.initials: K
authors.lastname: Sugino
authors.forename: Chikako
authors.initials: C
authors.lastname: Hasegawa
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Kimura
authors.forename: Go
authors.initials: G
authors.lastname: Sano
authors.forename: Kazutoshi
authors.initials: K
authors.lastname: Isobe
authors.forename: Kazutoshi
authors.initials: K
authors.lastname: Shibuya
authors.forename: Sakae
authors.initials: S
authors.lastname: Homma
mesh_terms: D000328:Adult; D000368:Aged; D001228:Aspergillosis / Q000473:pathology*; D005260:Female; D006801:Humans; D007938:Leukemia / Q000150:complications*; D008172:Lung Diseases, Fungal / Q000473:pathology*; D008297:Male; D008875:Middle Aged