title: Vitamin-E reduces the oxidative damage on delta-aminolevulinic dehydratase induced by lead intoxication in rat erythrocytes.
abstract: Lead intoxication induces oxidative damage on lipids and proteins. In the present paper we study in vivo and in vitro the antioxidant effect of vitamin-E and trolox, on the oxidative effects of lead intoxication in rat erythrocytes. Vitamin-E simultaneously administered to erythrocytes treated with lead was capable to prevent the inhibition of delta-aminolevulinic dehydratase activity and lipid oxidation. Partial but important protective effects were found when vitamin-E was administered either after or before lead exposure in rats. In vitro, the antioxidant trolox protected delta-ALA-D activity against damage induced by lead or menadione. These results indicate that vitamin-E could be useful in order to protect membrane-lipids and, notably, to prevent protein oxidation produced by lead intoxication.
authors.affiliation: Department of Biochemistry, CINVESTAV-IPN, P.O. Box 14-740, México City 07000, Mexico.
authors.forename: A
authors.initials: A
authors.lastname: Rendón-Ramirez
authors.forename: J
authors.initials: J
authors.lastname: Cerbón-Solórzano
authors.forename: M
authors.initials: M
authors.lastname: Maldonado-Vega
authors.forename: M A
authors.initials: MA
authors.lastname: Quintanar-Escorza
authors.forename: J V
authors.initials: JV
authors.lastname: Calderón-Salinas
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002839:Chromans / Q000494:pharmacology*; D004906:Erythrocyte Count; D004912:Erythrocytes / Q000187:drug effects* / Q000378:metabolism; D007854:Lead / Q000097:blood / Q000493:pharmacokinetics / Q000633:toxicity*; D015227:Lipid Peroxidation / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects; D000623:Porphobilinogen Synthase / Q000378:metabolism; D011524:Protoporphyrins / Q000097:blood; D051381:Rats; D017208:Rats, Wistar; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D014810:Vitamin E / Q000494:pharmacology*; D014815:Vitamins / Q000494:pharmacology
chemical_list: D000975:Antioxidants; D002839:Chromans; D011524:Protoporphyrins; D017392:Thiobarbituric Acid Reactive Substances; D014815:Vitamins; D014810:Vitamin E; D007854:Lead; D000623:Porphobilinogen Synthase; C010643:6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid