title: Erectile function outcome reporting after clinically localized prostate cancer treatment.
abstract: OBJECTIVE
  In conjunction with the assignment to update the Guidelines for Management of Clinically Localized Prostate Cancer, the American Urological Association Prostate Cancer Guideline Update Panel performed a side analysis of the reporting of erectile function outcomes in this clinical context as published in the medical literature.
  
  
  METHODS
  Four National Library of Medicine PubMed(R) Services literature searches targeting articles published from 1991 through early 2004 were done to derive outcome reporting (efficacy or side effects) for the treatment of clinical stage T1 or T2 N0M0 prostate cancer. A database was constructed containing descriptions relating to erectile function as well as numerical frequency rates of complete erectile dysfunction, and partial and intact erectile function for various treatments. A literature review was also done, consisting of a PubMed Services search of current measures and protocols used for assessing erectile function outcomes and a survey of consensus opinion sources on the management of male sexual dysfunctions.
  
  
  RESULTS
  Based on inclusion criteria 436 articles were selected. Of these articles database extraction from 100 pertaining to radical prostatectomy garnered various characterizations of erectile function, including qualitative descriptions, generic terminology and rating systems. Database extraction from 31 articles, in which results for at least 50 patients were reported, yielded ranges of rates for complete erectile dysfunction, partial erectile function and intact erectile function that were 26% to 100%, 16% to 48% and 9% to 86% for radical prostatectomy, 8% to 85%, 21% to 47% and 36% to 63% for external beam radiation, and 14% to 61%, 21% and 18% for interstitial radiation, respectively. The literature review showed an evolution in standards for studying and reporting erectile function outcomes.
  
  
  CONCLUSIONS
  Clinical studies reporting erectile function outcomes after localized prostate cancer treatment often demonstrate poorly interpretable and inconsistent manners of assessment as well as widely disparate rates of erectile dysfunction and erectile function. Future studies must apply scientifically rigorous methodology and standard outcomes measures to advance this field of study.
authors.affiliation: The Johns Hopkins Hospital, 600 North Wolfe St., Marburg 407, Baltimore, Maryland 21287-2411, USA. aburnett@jhmi.edu
authors.forename: Arthur L
authors.initials: AL
authors.lastname: Burnett
authors.forename: Gunnar
authors.initials: G
authors.lastname: Aus
authors.forename: Edith D
authors.initials: ED
authors.lastname: Canby-Hagino
authors.forename: Michael S
authors.initials: MS
authors.lastname: Cookson
authors.forename: Anthony V
authors.initials: AV
authors.lastname: D'Amico
authors.forename: Roger R
authors.initials: RR
authors.lastname: Dmochowski
authors.forename: David T
authors.initials: DT
authors.lastname: Eton
authors.forename: Jeffrey D
authors.initials: JD
authors.lastname: Forman
authors.forename: S Larry
authors.initials: SL
authors.lastname: Goldenberg
authors.forename: Javier
authors.initials: J
authors.lastname: Hernandez
authors.forename: Celestia S
authors.initials: CS
authors.lastname: Higano
authors.forename: Stephen
authors.initials: S
authors.lastname: Kraus
authors.forename: Monica
authors.initials: M
authors.lastname: Liebert
authors.forename: Judd W
authors.initials: JW
authors.lastname: Moul
authors.forename: Catherine
authors.initials: C
authors.lastname: Tangen
authors.forename: J Brantley
authors.initials: JB
authors.lastname: Thrasher
authors.forename: Ian
authors.initials: I
authors.lastname: Thompson
mesh_terms: D001918:Brachytherapy; D007172:Erectile Dysfunction / Q000209:etiology*; D006801:Humans; D008297:Male; D009367:Neoplasm Staging; D010043:Outcome and Process Assessment, Health Care; D011183:Postoperative Complications / Q000209:etiology*; D017410:Practice Guidelines as Topic; D011467:Prostate / Q000473:pathology / Q000601:surgery; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*; D011788:Quality of Life; D011867:Radioisotope Teletherapy; D016896:Treatment Outcome