A triple play for thyroid hormone.
A class of thyroid hormone metabolites has dramatic physiological effects on metabolism and heart rate by still-unknown mechanisms of action. A recent study has discovered that thyronamines can inhibit neuronal reuptake of neurotransmitters and prevent the intracellular transport of monoamines for release. This discovery presents a third signaling pathway for thyroid hormone, expands the role that thyroid plays in the central nervous system, and suggests mechanisms of action for the effects of thyronamine-derived neuromodulators.
Weatherman
Ross V
RV
Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana 47907, USA. rossw@pharmacy.purdue.edu
D000818:Animals; D006801:Humans; D018377:Neurotransmitter Agents / Q000378:metabolism; D017729:Presynaptic Terminals / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology; D013963:Thyroid Hormones / Q000378:metabolism*
D018377:Neurotransmitter Agents; D013963:Thyroid Hormones