title: Small-cell lung carcinoma produces salivary-type amylase: a case report with review.
abstract: A 53-year-old woman diagnosed with small-cell lung carcinoma (SCLC) was referred to our hospital because of general malaise and inappetence. Serum amylase levels were drastically elevated at 13,920 IU/l, with the salivary type dominating. She suffered multiple liver metastases and presented with disseminated intravascular coagulation (DIC). She succumbed to progressive malaise one month after admission. The amylase level was increased to 18,630 IU/l just before her death. Necropsy of the right supraclavicular lymph node confirmed SCLC with partial necrosis. Immunohistological analysis revealed that the SCLC produced salivary-type amylase. A rare case of salivary-type amylase-producing SCLC with a futile outcome was reported with review of the previous literature.
authors.affiliation: First Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto. se@hsp.md.shinshu-u.ac.jp
authors.forename: Seiichi
authors.initials: S
authors.lastname: Yamazaki
authors.forename: Shoichiro
authors.initials: S
authors.lastname: Ebisawa
authors.forename: Masanori
authors.initials: M
authors.lastname: Yasuo
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Urushihata
authors.forename: Tomonobu
authors.initials: T
authors.lastname: Koizumi
authors.forename: Keisaku
authors.initials: K
authors.lastname: Fujimoto
authors.forename: Keishi
authors.initials: K
authors.lastname: Kubo
mesh_terms: D000681:Amylases / Q000096:biosynthesis* / Q000097:blood; D018288:Carcinoma, Small Cell / Q000150:complications / Q000201:enzymology* / Q000556:secondary; D004211:Disseminated Intravascular Coagulation / Q000209:etiology; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary; D008175:Lung Neoplasms / Q000150:complications / Q000201:enzymology* / Q000473:pathology; D008875:Middle Aged; D012463:Saliva / Q000201:enzymology*
chemical_list: D000681:Amylases