[Morphological and proinflammatory expression of the experimental autoimmune prostatitis in the rat model].
OBJECTIVE
To establish a Wistar rat model of chronic abacterial prostatitis (CAP) by injecting purified prostate protein and Freund's complete adjuvant, and to study the influence on the morphology and proinflammatory expression.


METHODS
Male rats were injected with the Pertussis-Diphteria-Tetanus vaccine into the abdominal cavity and purified prostate protein and Freund's complete adjuvant intradermally at 0 and 30 days. At 60 days, the rats were sacrificed, and then the prostate specimens were observed, under the light microscope and electron microscope, and the changes of proinflammatory expression was observed too, using PCR technique.


RESULTS
The products of proinflammatory expression, such as eotaxin, iNOS and IL-4 increased markedly. The change of chronic inflammation was shown by light microscope and electron microscope.


CONCLUSIONS
Chronic prostatitis is associated with autoimmunity.
Chen
Lei
L
Department of Urology, Longhua Hospital Affiliated to Shanghai University of TCM, Shanghai 200032, China. joe8989@163.com
Xia
Wei-ping
WP
Zhou
Zhi-heng
ZH
D000818:Animals; D001327:Autoimmune Diseases / Q000473:pathology*; D002631:Chemotactic Factors, Eosinophil / Q000235:genetics; D004195:Disease Models, Animal; D015870:Gene Expression; D015847:Interleukin-4 / Q000097:blood; D008297:Male; D016133:Polymerase Chain Reaction; D011472:Prostatitis / Q000473:pathology*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
D002631:Chemotactic Factors, Eosinophil; D015847:Interleukin-4