Selective inhibition of CBP/p300 HAT.
In this issue of Chemistry & Biology, Mantelingu and colleagues present the development of the garcinol derivative LTK-14, which is a specific and nontoxic inhibitor of histone acetyltransferase p300-HAT [1]. Interestingly, it blocks histone acetylation of HIV-infected cells resulting in inhibition of the multiplication of HIV in these cells.
Sarli
Vasiliki
V
Institut für Organische Chemie, Universität Leipzig, Johannisallee 29, 04103 Leipzig, Germany. sarli@uni-leipzig.de
Giannis
Athanassios
A
D000818:Animals; D019380:Anti-HIV Agents / Q000737:chemistry / Q000494:pharmacology; D018797:Cell Cycle Proteins / Q000037:antagonists & inhibitors* / Q000235:genetics; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology; D051548:Histone Acetyltransferases / Q000037:antagonists & inhibitors* / Q000235:genetics; D006801:Humans; D015394:Molecular Structure; D013729:Terpenes / Q000737:chemistry / Q000494:pharmacology; D014157:Transcription Factors / Q000037:antagonists & inhibitors* / Q000235:genetics; D050880:p300-CBP Transcription Factors; D000099224:p300-CBP-Associated Factor
D019380:Anti-HIV Agents; D018797:Cell Cycle Proteins; D004791:Enzyme Inhibitors; D051548:Histone Acetyltransferases; D013729:Terpenes; D014157:Transcription Factors; D050880:p300-CBP Transcription Factors; D000099224:p300-CBP-Associated Factor; C054597:garcinol