Tissue synchronization imaging of myocardial dyssynchronicity of the left ventricle in patients with coronary artery disease.
OBJECTIVE
The purpose of this study was to evaluate regional myocardial dyssynchronicity and velocity of the left ventricle in patients with coronary artery disease.


METHODS
Tissue synchronization imaging analysis of the time to peak velocity (Tp) and peak velocity (Vp) of left ventricular longitudinal myocardial segments was performed for 60 patients with coronary artery disease and 40 healthy subjects.


RESULTS
Tissue synchronization imaging revealed synchronous myocardia in the control group and disturbed myocardial synchrony in patients, with greater dyssynchrony than in the control group (P < .005). Compared with the control group, patients showed a higher Tp of the left ventricular anterior wall and interventricular septum (P < .001). The apex-to-base gradient of tissue velocity was absent in patients. The mean Vp of all segments except the apical segment of the interventricular septum in patients was decreased significantly (P < .05).


CONCLUSIONS
Tissue synchronization imaging is a novel and noninvasive technique for quantitatively assessing regional myocardial Tp and Vp and can directly and quickly determine ischemia or infarction in myocardial segments.
Tian
Jia-Wei
JW
Department of Ultrasound, Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Rd, Nangang District, 150086 Harbin, China. jwtian2004@yahoo.com.cn
Du
Guo-Qing
GQ
Ren
Min
M
Sun
Li-Tao
LT
Leng
Xiao-Ping
XP
Su
Yan-Xin
YX
D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D003327:Coronary Disease / Q000000981:diagnostic imaging*; D004452:Echocardiography; D018618:Echocardiography, Doppler, Color; D004562:Electrocardiography; D005260:Female; D006346:Heart Septum / Q000503:physiopathology; D006352:Heart Ventricles / Q000503:physiopathology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000502:physiology; D009203:Myocardial Infarction / Q000175:diagnosis / Q000000981:diagnostic imaging; D017202:Myocardial Ischemia / Q000175:diagnosis / Q000000981:diagnostic imaging; D013997:Time Factors; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging*