Interpretive criteria to differentiate low- and high-level mupirocin resistance in Staphylococcus aureus.
Meticillin-resistant Staphylococcus aureus isolates were classified into three mupirocin susceptibility groups by the disc diffusion method using 5 and 200 microg mupirocin discs. The zone diameter observed for a 5 microg disc distinguished Mup(S) from the resistant strains (either Mup(RL) or Mup(RH)). On the other hand, a 200 microg disc distinguished the high-resistance Mup(RH) strains from the other two (Mup(S) or Mup(RL)). Thus, the concomitant use of 5 and 200 microg mupirocin discs allowed the clear distinction among the three mupirocin susceptibility groups, Mup(S), Mup(RL) or Mup(RH).
Moreira de Oliveira
Naira Elane
NE
Instituto de Microbiologia Prof. Paulo de Góes, Universidade Federal do Rio de Janeiro, RJ, Brazil.
Cardozo
Ana Paula Couto Marques
APCM
Instituto de Microbiologia Prof. Paulo de Góes, Universidade Federal do Rio de Janeiro, RJ, Brazil.
Marques
Elizabeth de Andrade
EA
Faculdade de Ciências Medicas, Universidade do Estado do Rio de Janeiro, RJ, Brazil.
Netto Dos Santos
Kátia Regina
KR
Instituto de Microbiologia Prof. Paulo de Góes, Universidade Federal do Rio de Janeiro, RJ, Brazil.
deMarval
Marcia Giambiagi
MG
Instituto de Microbiologia Prof. Paulo de Góes, Universidade Federal do Rio de Janeiro, RJ, Brazil.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D006801:Humans; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests / Q000379:methods / Q000592:standards*; D016712:Mupirocin / Q000494:pharmacology*; D013203:Staphylococcal Infections / Q000382:microbiology; D013211:Staphylococcus aureus / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D016712:Mupirocin