[Application of proteomics to diagnosis and treatment of lung cancer].
With the completion of human genome sequence project (HGP), the application of two-dimensional gel electrophoresis (2-DE), mass spectrometry (MS), and bioinformatics, more achievements have been made in proteomics research. From the new point of view, looking for tumor-specific proteins with proteomics research strategy may help to elucidate the correlation of the change of protein expression to oncogenesis, and may play a vital role in the early detection of cancer and anticancer therapy including drug exploitation. This article briefly reviewed the relevant techniques, strategies, and application of proteomics research on lung cancer.
Dai
Ming
M
Center of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P. R. China.
Luo
Rong-Cheng
RC
D014408:Biomarkers, Tumor / Q000378:metabolism; D016503:Drug Delivery Systems; D015180:Electrophoresis, Gel, Two-Dimensional; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000378:metabolism / Q000628:therapy; D020543:Proteome / Q000378:metabolism*; D040901:Proteomics / Q000379:methods*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
D014408:Biomarkers, Tumor; D020543:Proteome