Predicting the chromatographic retention of polymers: poly(methyl methacrylate)s and polyacryate blends.
The suitability of a retention model especially designed for polymers is investigated to describe and predict the chromatographic retention behavior of poly(methyl methacrylate)s as a function of mobile phase composition and gradient steepness. It is found that three simple yet rationally chosen chromatographic experiments suffice to extract the analyte specific model parameters necessary to calculate the retention volumes. This allows predicting accurate retention volumes based on a minimum number of initial experiments. Therefore, methods for polymer separations can be developed in relatively short time. The suitability of the virtual chromatography approach to predict the separation of polymer blend is demonstrated for the first time using a blend of different polyacrylates.
Bashir
Mubasher A
MA
Deutsches Kunststoff-Institut (German Institute for Polymers), Schlossgartenstr. 6, D-64289 Darmstadt, Germany.
Radke
Wolfgang
W
D000179:Acrylates / Q000737:chemistry*; D000327:Adsorption; D002850:Chromatography, Gel / Q000379:methods*; D020366:Methylmethacrylate / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry* / Q000302:isolation & purification
D000179:Acrylates; D011108:Polymers; D020366:Methylmethacrylate; C036658:acrylic acid