title: [Expression of lipopolysaccharide receptors CD14 and TLR4 in a model of rat molar apical periodontitis].
abstract: OBJECTIVE
  To characterize the expression of lipopolysaccharide (LPS) receptors-CD14 and TLR4 in rat peri-radicular tissue and to investigate the signal transduction pathway of LPS and its receptors in periapical periodontitis.
  
  
  METHODS
  After establishment of a model of rat molar LPS-induced apical periodontitis, CD14 and TLR4 expression in healthy and inflammatory periapical tissue were determined by immunohistochemistry.
  
  
  RESULTS
  CD14 and TLR4 were not detected in healthy periapical tissue but strongly positive in inflammatory periapical tissue. Positive cells were mostly monocytes/macrophages.
  
  
  CONCLUSIONS
  CD14 and TLR4 may play an important role in the pathogenesis of periapical periodontitis, probably via immune cells such as monocytes/macrophages and neutrophils.
authors.affiliation: Department of Cariology and Endodontology, Faculty of Stomatology, Capital University of Medical Sciences, Beijing 100050, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Zhang
authors.forename: Ben-xiang
authors.initials: BX
authors.lastname: Hou
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D018950:Lipopolysaccharide Receptors / Q000378:metabolism*; D008070:Lipopolysaccharides / Q000633:toxicity; D010485:Periapical Periodontitis / Q000139:chemically induced / Q000378:metabolism* / Q000473:pathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D015398:Signal Transduction; D051197:Toll-Like Receptor 4 / Q000378:metabolism*
chemical_list: D018950:Lipopolysaccharide Receptors; D008070:Lipopolysaccharides; C495347:Tlr4 protein, rat; D051197:Toll-Like Receptor 4