Stevens-Johnson syndrome in children receiving phenobarbital therapy and cranial radiotherapy.
Stevens-Johnson syndrome (SJS) is a severe cutaneous eruption that most often appears as an adverse reaction to medication. In this report, we present two children with brain tumour who developed SJS while receiving cranial irradiation and anticonvulsant therapy with phenobarbital. Concomitant application of these two therapies may play an important role in the occurrence of the disease.
Ruggiero
Antonio
A
Department of Paediatrics, Pediatric Oncology, Università Cattolica del Sacro Cuore, Policlinico A. Gemelli, Rome, Italy.
Buonuomo
Paola Sabrina
PS
Maurizi
Palma
P
Cefalo
Maria Giuseppina
MG
Cefalo
Maria Pia
MP
Corsello
Mirta
M
Riccardi
Riccardo
R
D000927:Anticonvulsants / Q000009:adverse effects*; D001932:Brain Neoplasms / Q000150:complications* / Q000532:radiotherapy / Q000601:surgery; D002648:Child; D003131:Combined Modality Therapy / Q000009:adverse effects; D016371:Cranial Irradiation / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008527:Medulloblastoma / Q000150:complications* / Q000532:radiotherapy / Q000601:surgery; D010634:Phenobarbital / Q000009:adverse effects*; D013262:Stevens-Johnson Syndrome / Q000209:etiology*; D016896:Treatment Outcome
D000927:Anticonvulsants; D010634:Phenobarbital