title: Duration of neutralizing antibody titer after Japanese encephalitis vaccination.
abstract: In paired serum samples collected from 17 children, we measured neutralizing antibody (NTAb) titers after the second series of routine Japanese encephalitis (JE) vaccination in Japan to estimate the duration of NTAb titer when children did not receive the third series of routine vaccination by applying a random coefficient model. We also measured NTAb titers in adult serum samples to confirm the duration of NTAb titer estimated in the analysis of pediatric serum samples. In the absence of the third series of routine vaccination, 18% (3/17), 47% (8/17), 82% (14/17) and 100% (17/17) of children were estimated to become NTAb negative at 5, 10, 15, and 20 years after the second series of routine vaccination, respectively. Of 38 adults, 39.5% (15/38) became NTAb negative; the percentage was somewhat lower than that of antibody-negative children. The results suggested that JE vaccination schedule should be reevaluated in the future.
authors.affiliation: The Chemo-Sero-Therapeutic Research Institute, Kikuchi Research Center, Kumamoto, Japan. abe-mo@kaketsuken.or.jp
authors.forename: Motoharu
authors.initials: M
authors.lastname: Abe
authors.forename: Kenji
authors.initials: K
authors.lastname: Okada
authors.forename: Kenshi
authors.initials: K
authors.lastname: Hayashida
authors.forename: Fujio
authors.initials: F
authors.lastname: Matsuo
authors.forename: Kouichi
authors.initials: K
authors.lastname: Shiosaki
authors.forename: Chiaki
authors.initials: C
authors.lastname: Miyazaki
authors.forename: Kohji
authors.initials: K
authors.lastname: Ueda
authors.forename: Yoichiro
authors.initials: Y
authors.lastname: Kino
mesh_terms: D000328:Adult; D000914:Antibodies, Viral / Q000096:biosynthesis / Q000097:blood*; D002675:Child, Preschool; D004664:Encephalitis Virus, Japanese / Q000276:immunology*; D004672:Encephalitis, Japanese / Q000276:immunology* / Q000517:prevention & control; D006801:Humans; D007115:Immunization Schedule; D022321:Japanese Encephalitis Vaccines / Q000008:administration & dosage / Q000276:immunology*; D008875:Middle Aged; D015233:Models, Statistical; D009500:Neutralization Tests
chemical_list: D000914:Antibodies, Viral; D022321:Japanese Encephalitis Vaccines