[Bronchial asthma due to storage mite allergy].
In a multicenter study (7 participating centres) 132 patients with bronchial asthma (grade II or III) and sensitization to storage mites (SM) and/or house dust mites (HSM) were screened and asked to undergo further allergological evaluation. 90 patients agreed. In addition to routine skin prick tests and RAST, quantitative skin prick tests (QSPT) and bronchial provocation tests (BPT) were also performed with the suspected mite allergens. The results were correlated with aspects of the domestic and working environments. Furthermore we questioned whether the outcome of BPT could be predicted from the results of the routine skin tests/RAST and QSPT respectively. Out of a total of 145 BPTs there were 79 positive results with SM and/or HSM. Three patients were mono-allergic to SM. The correlation with the domestic environment was unremarkable. Correlation with occupational factors revealed a strong predominance of farmers (42 of 90) and suggested the same for professions involved in work in dust-laden environments like bakers (5 of 90) and workers in wood- and paper industry (7 of 90). This also means, that SM-allergy occurs in persons not occupationally exposed to dust. A prediction as to the allergological relevance of SM-allergen was not possible from viewing the routine skin prick test however positive RAST data showed a significant correlation with positive BPT to SM Lepidoglyphus. Similarly it was possible to draw an inference from QSPT as to the relevant allergy. With a positive QSPT to the SM Lepidoglyphus destructor a positive result with a BPT was highly probable. Due to small numbers it is not possible to make a similar statement for the other SM species (Acarus and Tyrophagus).
Kroidl
R F
RF
Wissenschaftliche Arbeitsgemeinschaft zur Therapie von Lungenkrankheiten e.V. Rolf.Kroidl@t-online.de
Schwichtenberg
U
U
Frank
E
E
D000818:Animals; D001249:Asthma / Q000209:etiology*; D001985:Bronchial Provocation Tests; D004391:Dust; D006798:Housing; D006801:Humans; D006967:Hypersensitivity / Q000150:complications / Q000209:etiology*; D008925:Mites / Q000276:immunology*; D016273:Occupational Exposure
D004391:Dust