[Different courses of esomeprazole-based triple therapy for Helicobactor pylori infection in children].
OBJECTIVE
To study the efficacy of esomeprazole-based 1 week or 2 weeks triple therapy for Helicobactor pylori (H. pylori) infection in children.


METHODS
One hundred and five children with H. pylori infection identified by 13C-UBT were randomly assigned into Group A (n=60) and Group B (n=45). The patients of the two groups were administered with 1 week or 2 weeks triple therapy consisting of esomeprazole, clarithromycin and amoxillin, respectively. They were followed up four weeks after drug withdrawal.


RESULTS
Recurrent abdominal pain was relieved in all of patients. Fifty-five patients (91.7%) showed 13C-UBT negative in Group A and 42 (93.3%) presented negative in Group B. There was no significant difference in the eradication rate of H. pylori.


CONCLUSIONS
Esomeprazole-based triple therapy for H. pylori infection is effective in children. The efficacy of esomeprazole-based 1 week or 2 weeks triple therapy for this disorder does not appear to be different.
Xiang
Li
L
Department of Pediatrics, Second Affiliated Hospital, Medical College of Jinan University, Shenzhen, Guangdong 518020, China.
Wen
Fei-Qiu
FQ
Zuo
Wei-Hua
WH
Tang
Yi
Y
D000293:Adolescent; D000658:Amoxicillin / Q000008:administration & dosage*; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D000897:Anti-Ulcer Agents / Q000008:administration & dosage*; D002648:Child; D002675:Child, Preschool; D017291:Clarithromycin / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D064098:Esomeprazole / Q000008:administration & dosage*; D005260:Female; D016481:Helicobacter Infections / Q000188:drug therapy*; D016480:Helicobacter pylori; D006801:Humans; D008297:Male
D000900:Anti-Bacterial Agents; D000897:Anti-Ulcer Agents; D000658:Amoxicillin; D017291:Clarithromycin; D064098:Esomeprazole