Deacylation studies on furanose triesters using an immobilized lipase: synthesis of a key precursor for bicyclonucleosides.
Lipozyme TL IM immobilized on silica catalyses the deacylation of 4-C-acyloxymethyl-3,5-di-O-acyl-1,2-O-(1-methylethylidene)-beta-L-threo-pentofuranose to form 3,5-di-O-acyl-4-C-hydroxymethyl-1,2-O-(1-methylethylidene)-alpha-d-xylo-pentofuranose in a highly selective and efficient manner.
Prasad
Ashok K
AK
Bioorganic Laboratory, Department of Chemistry, University of Delhi, Delhi 110 007, India.
Kalra
Neerja
N
Yadav
Yogesh
Y
Kumar
Rajesh
R
Sharma
Sunil K
SK
Patkar
Shamkant
S
Lange
Lene
L
Wengel
Jesper
J
Parmar
Virinder S
VS
D000215:Acylation; D002384:Catalysis; D002855:Chromatography, Thin Layer; D004800:Enzymes, Immobilized / Q000737:chemistry*; D004952:Esters / Q000737:chemistry; D007202:Indicators and Reagents; D008049:Lipase / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D009005:Monosaccharides / Q000737:chemistry*; D012822:Silicon Dioxide
D004800:Enzymes, Immobilized; D004952:Esters; D007202:Indicators and Reagents; D009005:Monosaccharides; D012822:Silicon Dioxide; D008049:Lipase