title: Synthesis of hyaluronic acid oligomers using Ph2SO/Tf2O-mediated glycosylations.
abstract: The synthesis of hyaluronic acid (HA) oligomers using a stepwise glycosylation strategy is described. This method employs protected 1-hydroxyuronic acid and 1-phenylthio glucosamine donors, both of which are activated with the Ph2SO/Tf2O activator system.
authors.affiliation: Leiden Institute of Chemistry, Leiden University, P.O. Box 9502, 2300 RA Leiden, The Netherlands.
authors.forename: Jasper
authors.initials: J
authors.lastname: Dinkelaar
authors.forename: Jeroen D C
authors.initials: JD
authors.lastname: Codée
authors.forename: Leendert J
authors.initials: LJ
authors.lastname: van den Bos
authors.forename: Herman S
authors.initials: HS
authors.lastname: Overkleeft
authors.forename: Gijsbert A
authors.initials: GA
authors.lastname: van der Marel
mesh_terms: D002240:Carbohydrate Sequence; D006031:Glycosylation; D006820:Hyaluronic Acid / Q000138:chemical synthesis*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008969:Molecular Sequence Data; D011108:Polymers / Q000138:chemical synthesis*
chemical_list: D011108:Polymers; D006820:Hyaluronic Acid