The impact of sex and sex hormones on lung physiology and disease: lessons from animal studies.
Numerous animal studies have revealed significant effects of sex and sex hormones on normal lung development, lung physiology, and various lung diseases. The primary goal of this review is to summarize knowledge to date on the effects of sex and sex hormones on lung development, physiology, and disease in animals. Specific emphasis will be placed on fibrosis, allergic airway disease, acute lung injury models, respiratory infection, and lung toxicology studies.
Carey
Michelle A
MA
National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.
Card
Jeffrey W
JW
Voltz
James W
JW
Germolec
Dori R
DR
Korach
Kenneth S
KS
Zeldin
Darryl C
DC
D000728:Androgens / Q000502:physiology*; D000818:Animals; D004967:Estrogens / Q000502:physiology*; D008168:Lung / Q000502:physiology*; D008171:Lung Diseases / Q000503:physiopathology*; D012727:Sex Characteristics
D000728:Androgens; D004967:Estrogens