Thymoquinone decreases AGE-induced NF-kappaB activation in proximal tubular epithelial cells.
The inhibitory effects of thymoquinone (TQ) on activation of the redox-sensitive transcription factor nuclear factor kappa B (NF-kappaB) and interleukin-6 (IL-6) were studied in vitro. Human proximal tubular epithelial cells (pTECs) were cultivated and stimulated with advanced glycation end products (AGEs) and the effects of TQ were studied. A significant reduction of AGE-induced NF-kappaB-activation and Il-6 expression was observed. This points to potential antioxidative qualities of TQ.
Sayed
Ahmed Amir Radwan
AA
Chemistry Department, Faculty of Science, Minia University, El-Minia 61519, Egypt. sayedaar@yahoo.de
Morcos
Michael
M
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D016227:Benzoquinones / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D002478:Cells, Cultured; D017127:Glycation End Products, Advanced / Q000378:metabolism; D006801:Humans; D015850:Interleukin-6 / Q000378:metabolism; D007684:Kidney Tubules / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D016328:NF-kappa B / Q000378:metabolism; D031881:Nigella sativa; D008517:Phytotherapy; D010938:Plant Oils / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
D000894:Anti-Inflammatory Agents, Non-Steroidal; D016227:Benzoquinones; D017127:Glycation End Products, Advanced; D015850:Interleukin-6; D016328:NF-kappa B; D010938:Plant Oils; C003466:thymoquinone