title: Continuous monitoring of ScvO(2) by a new fibre-optic technology compared with blood gas oximetry in critically ill patients: a multicentre study.
abstract: OBJECTIVE
  The aim of this study was to compare the accuracy of the CeVOX monitor measuring continuous central venous saturation (ScvO(2)) with laboratory blood gas oximetry under clinical circumstances.
  
  
  METHODS
  Prospective, multicentre, observational study.
  
  
  METHODS
  Five adult general intensive care units.
  
  
  METHODS
  Fifty-three critically ill patients.
  
  
  METHODS
  The fibre-optic probe was inserted into an ordinary central venous catheter's distal lumen. Blood samples were taken from this line via a Y-adapter every 8 h and ScvO(2) was measured with a laboratory co-oximeter. Patients were observed for a maximum of 5 days. Results were compared using linear regression and the Bland and Altman plots.
  
  
  RESULTS
  The 526 matched pairs of ScvO(2) showed a significant correlation between the two methods (r = 0.79, p< 0.001). Bland-Altman plots showed an overall mean bias of -0.3% and moderate agreement (lower and upper levels of agreement: -13.2% and 12.5%). Correlation for the first time point, and for differences between the first two time points for each method revealed good correlation: (n = 53): r = 0.79, p< 0.001; (n = 50): r = 0.58, p< 0.001, respectively.
  
  
  CONCLUSIONS
  These results in a heterogeneous group of critically ill patients show that continuous ScvO(2) monitoring by the CeVOX technology yielded results comparable with those obtained by laboratory co-oximetry and therefore can be relied on in everyday clinical practice.
authors.affiliation: Department of Anaesthesia and Intensive Therapy, University of Pécs, 13 Ifjusag St., 7624, Pécs, Hungary. zsoltmolna@gmail.com
authors.forename: Zsolt
authors.initials: Z
authors.lastname: Molnar
authors.forename: Andreas
authors.initials: A
authors.lastname: Umgelter
authors.forename: Ildiko
authors.initials: I
authors.lastname: Toth
authors.forename: David
authors.initials: D
authors.lastname: Livingstone
authors.forename: Andreas
authors.initials: A
authors.lastname: Weyland
authors.forename: Samir G
authors.initials: SG
authors.lastname: Sakka
authors.forename: Andreas
authors.initials: A
authors.lastname: Meier-Hellmann
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001784:Blood Gas Analysis / Q000295:instrumentation / Q000379:methods*; D003422:Critical Care / Q000379:methods*; D016638:Critical Illness; D005260:Female; D005336:Fiber Optic Technology; D006801:Humans; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic / Q000295:instrumentation / Q000379:methods; D010092:Oximetry; D010100:Oxygen / Q000097:blood*
chemical_list: D010100:Oxygen