Role of reactive oxygen species in mediating hepatic ischemia-reperfusion injury and its therapeutic applications in liver transplantation.
Increasing evidence has shown that reactive oxygen species (ROS) are important mediators in liver ischemia/reperfusion injury(IRI). ROS include hydrogen peroxide (H(2)O(2)), superoxide anion (O(-2)), and hydroxyl radical (HO(-)), which may be generated by activated Kupffer cells in the liver, contributing to reperfusion injury. Hepatic IRI is a multistep process that damages liver graft function. To establish a series of therapeutic strategies to improve the outcome of liver transplantation, a good understanding of the mechanisms of IRI is essential. However, the detail mechanisms of how ROS lead to hepatocyte damage in IRI remains unclear. The aim of this review was to describe recent developments in the field of oxidative stress research. The first part of this review focused on the key roles and possible mechanisms of ROS in hepatic IRI. The second part of this review summarizes some findings including novel and classic antioxidant methods to ameliorate the hepatocyte damage during IRI.
Zhang
W
W
Key Lab of Zhejiang Province Combined Multi-Organ Transplantation, Ministry of Public Health, and Dept. of Hepato-Biliary-Pancreatic Surgery, Zhejiang University, 79 Qingchun Road, Hangzhou, Zhejiang 310003, P.R. China.
Wang
M
M
Xie
H Y
HY
Zhou
L
L
Meng
X Q
XQ
Shi
J
J
Zheng
S
S
D000975:Antioxidants / Q000627:therapeutic use*; D001205:Ascorbic Acid / Q000627:therapeutic use; D016166:Free Radical Scavengers / Q000032:analysis / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000627:therapeutic use; D006801:Humans; D019194:Ischemic Preconditioning / Q000379:methods*; D008102:Liver Circulation; D017093:Liver Failure / Q000601:surgery; D016031:Liver Transplantation / Q000379:methods / Q000502:physiology*; D010544:Peroxidases / Q000627:therapeutic use; D054464:Peroxiredoxins; D017382:Reactive Oxygen Species / Q000032:analysis / Q000378:metabolism*; D015427:Reperfusion Injury / Q000503:physiopathology* / Q000517:prevention & control; D013879:Thioredoxins / Q000627:therapeutic use
D000975:Antioxidants; D016166:Free Radical Scavengers; D017382:Reactive Oxygen Species; D013879:Thioredoxins; D010544:Peroxidases; D054464:Peroxiredoxins; D005979:Glutathione Peroxidase; D001205:Ascorbic Acid