[Msx1 and its influence on craniofacial growth].
Many genes that interact in a complex and interdependent manner participate in the development of the craniofacial complex. One of them, the Msxl homeobox gene, a transcription factor, is expressed from early developmental stages to adulthood in accordance with specific spatio-temporal patterns. When it is suppressed, transgenic mice exhibit craniofacial abnormalities that demonstrate what is its function in normal growth, just as it has been shown that certain Msxl mutations in humans are commonly associated with tooth agenesis.
Vi-Fane
Brigitte
B
Université Denis Diderot (Paris VII), Faculté de Chirurgie Dentaire, 5 rue Garancière, 75006 Paris, France. brigitte.vi-fane@wanadoo.fr
Fernandes
Isabelle
I
Davideau
Jean-Luc
JL
D000818:Animals; D047108:Embryonic Development / Q000235:genetics; D005147:Facial Bones / Q000196:embryology; D005786:Gene Expression Regulation / Q000235:genetics; D018507:Gene Expression Regulation, Developmental / Q000235:genetics; D006801:Humans; D051957:MSX1 Transcription Factor / Q000235:genetics* / Q000502:physiology; D008445:Maxillofacial Development / Q000235:genetics*; D051379:Mice; D008822:Mice, Transgenic; D009154:Mutation / Q000235:genetics; D014158:Transcription, Genetic / Q000235:genetics
D051957:MSX1 Transcription Factor