title: A concise synthetic approach to beta,gamma-dehydrocurvularin: synthesis of (+/-)-di-O-methyl-beta,gamma-dehydrocurvularin.
abstract: A concise synthesis of di-O-methyl-beta,gamma-dehydrocurvularin, the di-O-methylated derivative of the naturally occurring nematicidal macrolide, beta,gamma-dehydrocurvuralin, was accomplished by starting from a commercially available aromatic carboxylic acid in a three-step sequence consisting of esterification, Friedel-Crafts acylation, and microwave-promoted ring-closing metathesis.
authors.affiliation: Laboratory of Applied Bioorganic Chemistry, Graduate School of Agricultural Science, Tohoku University, Japan.
authors.forename: Takuho
authors.initials: T
authors.lastname: Miyagi
authors.forename: Shigefumi
authors.initials: S
authors.lastname: Kuwahara
mesh_terms: D000969:Antinematodal Agents / Q000138:chemical synthesis*; D002264:Carboxylic Acids; D003500:Cyclization; D004951:Esterification; D018942:Macrolides / Q000138:chemical synthesis*; D008872:Microwaves; D015025:Zearalenone / Q000031:analogs & derivatives* / Q000138:chemical synthesis
chemical_list: D000969:Antinematodal Agents; D002264:Carboxylic Acids; D018942:Macrolides; C013914:dehydrocurvularin; D015025:Zearalenone; C013455:curvularin