title: Plasminogen Activator Inhibitor-1 (PAI-1) gene 4G/5G alleles frequency distribution in the Lebanese population.
abstract: Plasminogen activator inhibitor-1 (PAI-1) is an inhibitor of fibrinolysis. Increased plasma PAI-1 levels play an essential role in the pathogenesis of cardiovascular risk and other diseases associated with thrombosis. The 4G/5G polymorphism of the PAI-1 promoter region has been extensively studied in different populations. We studied 160 healthy unrelated Lebanese individuals using a reverse hybridization PCR assay to detect the 5G/5G, 4G/5G and, 4G/4G genotypes of the PAI-1 gene and the frequencies of the 4G and 5G alleles. We found that 4G/5G genotype was the most prevalent (45.6%) followed by 5G/5G (36.9%) and 4G/4G (17.5%). The frequencies of the 4G and 5G alleles were calculated to be 0.403 and 0.597, respectively. Compared to other ethnic communities, the Lebanese population was found to harbour a relatively high prevalence of the rare 4G allele. This, in turn, may predispose this population to develop cardiovascular diseases and other thrombotic clinical conditions. This study aids to enhance our understanding of the genetic features of the Lebanese population.
authors.affiliation: Department of Pathology and Laboratory Medicine, American University of Beirut Medical Center, Riad El Solh, Beirut, Lebanon.
authors.forename: Dina M R
authors.initials: DM
authors.lastname: Shammaa
authors.forename: Amira S
authors.initials: AS
authors.lastname: Sabbagh
authors.forename: Ali T
authors.initials: AT
authors.lastname: Taher
authors.forename: Ghazi S
authors.initials: GS
authors.lastname: Zaatari
authors.forename: Rami A R
authors.initials: RA
authors.lastname: Mahfouz
mesh_terms: D000483:Alleles; D005260:Female; D005838:Genotype; D006801:Humans; D007861:Lebanon; D008297:Male; D017395:Plasminogen Activator Inhibitor 1 / Q000235:genetics*
chemical_list: D017395:Plasminogen Activator Inhibitor 1