title: Harzianums A and B produced by a fungal strain, Hypocrea sp. F000527, and their cytotoxicity against tumor cell lines.
abstract: A new compound, harzianum B (1), was isolated from the culture broth of a fungal strain, Hypocrea sp. F000527, together with a known trichothecene, harzianum A (2). Its structure was determined by spectroscopic analyses including HRFAB-MS and various (1)H NMR and (13)C NMR spectral data. Harzianum B (1) was characterised as (E,Z,E)-2', 4', 6'-octatriendioic acid esterified on the 4beta-hydroxyl group of trichodermol. Harzianums A (2) and B (1) showed cytotoxicity against several human cancer cell lines.
authors.affiliation: School of Pharmacy, Shanghai, Jiao Tong University, Shanghai 200240, China. kimhz@sjtu.edu.cu
authors.forename: H-Z
authors.initials: HZ
authors.lastname: Jin
authors.forename: J-H
authors.initials: JH
authors.lastname: Lee
authors.forename: W-D
authors.initials: WD
authors.lastname: Zhang
authors.forename: H-B
authors.initials: HB
authors.lastname: Lee
authors.forename: Y-S
authors.initials: YS
authors.lastname: Hong
authors.forename: Y-H
authors.initials: YH
authors.lastname: Kim
authors.forename: J-J
authors.initials: JJ
authors.lastname: Lee
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D006801:Humans; D035901:Hypocrea / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D014255:Trichothecenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D014255:Trichothecenes; C087546:harzianum A