Thyroid gangliosides with high affinity for thyrotropin: potential role in thyroid regulation.
Thyroid cell membranes contain a multiplicity of gangliosides, some of which inhibit thyrotropin binding to thyroid membranes. The most potent inhibitor is a ganglioside which is present in only trace amounts and appears to have a novel structure. Thyroid gangliosides may play a role in relaying the hormonal message to the thyroid cell.
Mullin
B R
BR
Laboratory of Biochemical Pharmacology, National Institute of Arthritis, Metabolism, and Digestive Diseases, Bethesda, MD 20014, USA.
Pacuszka
T
T
Lee
G
G
Kohn
L D
LD
Brady
R O
RO
Fishman
P H
PH
D000818:Animals; D002417:Cattle; D002462:Cell Membrane / Q000378:metabolism; D005732:Gangliosides / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D012794:Sialic Acids / Q000032:analysis; D013961:Thyroid Gland / Q000378:metabolism*; D013972:Thyrotropin / Q000037:antagonists & inhibitors / Q000378:metabolism*
D005732:Gangliosides; D012794:Sialic Acids; D013972:Thyrotropin