title: Inclusion body myositis: current pathogenetic concepts and diagnostic and therapeutic approaches.
abstract: Inclusion body myositis is the most common acquired muscle disease in older individuals, and its prevalence varies among countries and ethnic groups. The aetiology and pathogenesis of sporadic inclusion body myositis are still poorly understood; however genetic factors, ageing, and environmental triggers might all have a role. Unlike other inflammatory myopathies, sporadic inclusion body myositis causes slowly progressing muscular weakness and atrophy, it has a distinctive pattern of muscle involvement, and is unresponsive to conventional forms of immunotherapy. This review covers the clinical presentation, diagnosis, treatment, and the latest information on genetic susceptibility and pathogenesis of sporadic inclusion body myositis.
authors.affiliation: Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Queen Elizabeth II Medical Centre, Perth, Australia.
authors.forename: Merrilee
authors.initials: M
authors.lastname: Needham
authors.forename: Frank L
authors.initials: FL
authors.lastname: Mastaglia
mesh_terms: D006801:Humans; D018979:Myositis, Inclusion Body / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology* / Q000628:therapy*