Dysgerminoma in three patients with Swyer syndrome.
BACKGROUND
Dysgerminoma is the most common malignant germ cell tumor of the ovary. This malignancy can be associated with pure gonadal dysgenesis or Swyer syndrome, mixed gonadal dysgenesis and partial gonadal dysgenesis.


METHODS
Dysgerminoma developed in 3 phenotypic female patients with 46 XY pure gonadal dysgenesis. All patients presented first with abdominopelvic mass. Laparatomy was done. 46 XY karyotype was made by lymphocyte culture. Then these patients underwent gonadectomy that histopathology results were streak ovaries without evidence for malignancy. Two patients received postoperative adjuvant therapy.


CONCLUSIONS
In Patients with Swyer syndrome the risk of dysgerminoma is high and gonadectomy is recommended. Also 5% of dysgerminomas are discovered in phenotypic female and 46 XY karyotype, thus in adolescent with dysgerminoimas and amenorrhea, karyotype should be done.
Behtash
Nadereh
N
Gynecology Oncology Department, Vali-Asr Hospital, Keshavarz Blvd,, Tehran 14194, Iran. nadbehtash@yahoo.com
Karimi Zarchi
Mojgan
M
D000293:Adolescent; D001707:Biopsy, Needle; D017024:Chemotherapy, Adjuvant; D004407:Dysgerminoma / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000601:surgery; D005260:Female; D006061:Gonadal Dysgenesis, 46,XY / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D007150:Immunohistochemistry; D007813:Laparotomy / Q000379:methods; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000601:surgery; D010052:Ovariectomy / Q000379:methods; D011379:Prognosis; D018570:Risk Assessment; D012494:Sampling Studies; D016896:Treatment Outcome; D018608:Ultrasonography, Doppler; D055815:Young Adult