[Hormones of youth?].
Ageing is doubtless complicated, lifelong process regarding many body systems, including endocrine system. Human hormonal system changes with age. Although these changes concern secretion of many hormones, they are not unidirectional, there are hormones secretion of which is diminished, whereas secretion of the others is augmented or not changed with age. A possible role of hormones which are often termed "hormones of youth"(growth hormone, melatonin, and dehydroepiandrosterone) in the ageing process is discussed in the present article. Although some experimental and clinical data indicate that these hormones may play some role in the human ageing process, it appears from presented data that we are still far away from conclusion that, indeed, one (or more) of the discussed hormones could be considered as "hormone of youth", which may slow down ageing process. However, some symptoms of the quality of life improvement following administration of dehydroepiandrosterone, melatonin, and growth hormone may suggest that they may promote so called "successful aging".
Karasek
Michał
M
Zakład Neuroendokrynologii, Katedra Endokrynologii, Uniwersytet Medyczny, Łódź. karasek@csk.umed.lodz.pl
D000368:Aged; D000375:Aging / Q000187:drug effects* / Q000502:physiology*; D003687:Dehydroepiandrosterone / Q000494:pharmacology*; D004703:Endocrine System / Q000378:metabolism*; D020249:Hormone Replacement Therapy; D006801:Humans; D008550:Melatonin / Q000494:pharmacology* / Q000627:therapeutic use; D011788:Quality of Life; D012060:Rejuvenation / Q000502:physiology*
D003687:Dehydroepiandrosterone; D008550:Melatonin