title: Case of localized bullous pemphigoid with unique clinical manifestations in the lower legs.
abstract: We report the case of a 71-year-old Japanese woman who presented with persistent band-like erosions in the lower legs. Histological examination suggested subepidermal blister formation. Direct and indirect immunofluorescence studies revealed tissue-deposited and circulating immunoglobulin G autoantibodies against the basement membrane. Western blotting revealed autoantibodies to BP230, but not to BP180. Based on these findings, the patient was diagnosed as having a localized type of bullous pemphigoid. We suggest that the unique clinical manifestations in this patient could be attributable to bacterial or fungal infection, and/or mechanical trauma, such as the pressure of her socks.
authors.affiliation: Department of Dermatology, Juntendo University School of Medicine, Bunkyo-ku, Tokyo, Japan.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Kohroh
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Suga
authors.forename: Yuki
authors.initials: Y
authors.lastname: Mizuno
authors.forename: Norito
authors.initials: N
authors.lastname: Ishii
authors.forename: Takashi
authors.initials: T
authors.lastname: Hashimoto
authors.forename: Shigaku
authors.initials: S
authors.lastname: Ikeda
mesh_terms: D000368:Aged; D001323:Autoantibodies / Q000097:blood; D005260:Female; D006801:Humans; D007159:Immunologic Tests; D007866:Leg / Q000473:pathology*; D010391:Pemphigoid, Bullous / Q000276:immunology / Q000473:pathology*; D012867:Skin / Q000276:immunology / Q000473:pathology*
chemical_list: D001323:Autoantibodies