The regulation of permeability barrier homeostasis.
Disruption of the permeability barrier stimulates a repair response that leads to the restoration of barrier function. Previous studies demonstrated that changes in ions, particularly calcium, and cytokines are positive signals, whereas serine protease activation of proteinase-activated receptor 2 is a negative signal regulating barrier recovery. Ikeyama and colleagues provide data that the nitric oxide signaling pathway also regulates barrier homeostasis.
Feingold
Kenneth R
KR
Department of Medicine, University of California, San Francisco, and Veterans Affairs Medical Center, San Francisco, California 94121, USA. kenneth.feingold@ucsf.edu
Schmuth
Matthias
M
Elias
Peter M
PM
D000818:Animals; D002118:Calcium / Q000502:physiology; D002463:Cell Membrane Permeability / Q000502:physiology*; D016207:Cytokines / Q000502:physiology; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D009569:Nitric Oxide / Q000502:physiology*; D052248:Nitric Oxide Synthase Type I / Q000235:genetics / Q000502:physiology; D044464:Receptor, PAR-2 / Q000235:genetics / Q000502:physiology; D012697:Serine Endopeptidases / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D012867:Skin / Q000166:cytology; D012879:Skin Physiological Phenomena
D016207:Cytokines; D044464:Receptor, PAR-2; D009569:Nitric Oxide; D052248:Nitric Oxide Synthase Type I; D012697:Serine Endopeptidases; D002118:Calcium