VEGF 936 C/T gene polymorphism in renal transplant recipients: association of the T allele with good graft outcome.
We investigated the possible impact of vascular endothelial growth factor (VEGF) 936 C/T gene polymorphism on kidney graft outcome. DNA samples of 290 first deceased donor kidney graft recipients with well-functioning grafts and no rejection treatment during the first transplant year (WFG), 265 recipients with graft failure within the first transplant year (F), and 187 healthy control subjects were tested using the polymerase chain reaction restriction fragment length polymorphism technique. Although VEGF 936 CT genotype and T allele carrier frequencies in 555 kidney graft recipients did not differ significantly from frequencies observed in healthy control subjects, significantly higher frequencies were found in WFG patients (CT: 19.0%, T: 20.7%) than in F patients (CT: 11.7%, p=0.019; T: 12.8%, p=0.017, respectively). The VEGF 936 CT genotype and T allele appear to be associated with good outcome in renal transplantation and, if confirmed, might be helpful for the pretransplant identification of recipients with low risk of graft rejection.
Günesacar
Ramazan
R
Department of Immunology and Rheumatology, Faculty of Medicine, University of Cukurova, Adana, Turkey. gamgul@cu.edu.tr
Opelz
Gerhard
G
Erken
Eren
E
Pelzl
Steffen
S
Döhler
Bernd
B
Ruhenstroth
Andrea
A
Süsal
Caner
C
D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006084:Graft Rejection / Q000235:genetics* / Q000276:immunology; D006085:Graft Survival / Q000235:genetics*; D006801:Humans; D007668:Kidney / Q000098:blood supply / Q000276:immunology*; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D042582:Vascular Endothelial Growth Factor C / Q000097:blood / Q000235:genetics* / Q000276:immunology
D042582:Vascular Endothelial Growth Factor C