title: Reversing left ventricular remodeling in chronic heart failure: surgical approaches.
abstract: Chronic heart failure (CHF) has become an epidemic in the United States, with approximately 550,000 new cases annually. With the evolution of pharmacotherapy targeting neurohormonal pathways, the annual mortality in subjects with New York Heart Association (NYHA) class IV CHF has dramatically improved from 52% in the seminal CONSENSUS trial to less than 20% in more recent trials. Suppression of the renin-angiotensin-aldosterone system remains the first line of neurohormonal blockade followed by the addition of selective beta-adrenoreceptor blockers. For patients with NYHA class I and II symptoms, mortality rates have decreased to approximately 5% or less per year with the use of angiotensin-converting enzyme inhibitors, beta-blockers and aldosterone receptor blockers. However, after achieving optimal doses of the indicated pharmacotherapy, and despite the additional benefits obtained with biventricular pacemakers, there are still many patients who continue to experience signs and symptoms of CHF. Recognizing the beneficial effects of the above treatments on left ventricular (LV) remodeling, strategies have been developed to surgically reshape the left ventricle in patients with LV dilation who have associated poor LV function. This review will discuss the techniques and recent developments regarding surgical reshaping of the dilated, dysfunctional, and remodeled left ventricle.
authors.affiliation: Heart Failure Center, Leon Charney Division of Cardiology, New York University School of Medicine, New York, New York, USA.
authors.forename: Kartikya
authors.initials: K
authors.lastname: Ahuja
authors.forename: Gregory A
authors.initials: GA
authors.lastname: Crooke
authors.forename: Eugene A
authors.initials: EA
authors.lastname: Grossi
authors.forename: Aubrey C
authors.initials: AC
authors.lastname: Galloway
authors.forename: Ulrich P
authors.initials: UP
authors.lastname: Jorde
mesh_terms: D006348:Cardiac Surgical Procedures / Q000295:instrumentation / Q000379:methods; D006333:Heart Failure / Q000150:complications* / Q000503:physiopathology / Q000601:surgery*; D006352:Heart Ventricles / Q000601:surgery*; D006353:Heart-Assist Devices; D006801:Humans; D019651:Plastic Surgery Procedures / Q000295:instrumentation / Q000379:methods; D016896:Treatment Outcome; D020257:Ventricular Remodeling