title: Gypsophin: a novel alpha-glucosidase inhibitory cyclic peptide from the roots of Gypsophila oldhamiana.
abstract: An unusual new cyclic peptide with a pyrrolidine-2,5-dione unit, gypsophin (1), was isolated from Gypsophila oldhamiana. Its structure was elucidated by the spectroscopic evidences. The stereochemistry was determined by application of the Marfey's method and the single-crystal X-ray diffraction. Compound 1 exhibited inhibitory activity against alpha-glucosidase with IC50 of 305 microM.
authors.affiliation: Department of Natural Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, PR China.
authors.forename: Jian-Guang
authors.initials: JG
authors.lastname: Luo
authors.forename: Xiao-Bing
authors.initials: XB
authors.lastname: Wang
authors.forename: Li
authors.initials: L
authors.lastname: Ma
authors.forename: Ling-Yi
authors.initials: LY
authors.lastname: Kong
mesh_terms: D029748:Caryophyllaceae / Q000737:chemistry*; D065089:Glycoside Hydrolase Inhibitors; D008958:Models, Molecular; D010456:Peptides, Cyclic / Q000737:chemistry* / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry*
chemical_list: D065089:Glycoside Hydrolase Inhibitors; D010456:Peptides, Cyclic; C524173:gypsophin