[Study on preparation technology of plumula nelumbinis Alkaloid Dripping Pill and determination of content by HPLC].
OBJECTIVE
To determine the optimum technical parameters through controlling the different factors and the content of Dripping Pill.


METHODS
Time of dissolution, spherical degree and pill weight as parameters, the influential factors were investigated by orthogonal test and then to determine the content of liensinine, isoliensinine, neferine in plumula nelumbinis Alkaloid Dripping Pill.


RESULTS
The optimum condition: 75% PEG4000 as matrix, methyl-silicon oil as refrigerant, 4 cm dripping distance, 10 degrees C refrigerant, 30 drippings per minute.


CONCLUSIONS
The good quality pills can be produced through this process and the HPLC determination method is simple, reliable and can be used in the quality control of plumula nelumbinis Alkaloid Dripping Pill.
Liu
Wei
W
Institute of Chinese Meteria Medica, China Academg of Chinese Medical Sciences, Beijing 100700, China.
Wang
Hong-Jie
HJ
Si
Nan
N
Bian
Bao-Lin
BL
D000470:Alkaloids / Q000032:analysis* / Q000737:chemistry; D044182:Benzylisoquinolines / Q000032:analysis / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D007546:Isoquinolines / Q000032:analysis / Q000737:chemistry; D008863:Microspheres; D031653:Nelumbo / Q000737:chemistry*; D010316:Particle Size; D010636:Phenols / Q000032:analysis / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry*; D011786:Quality Control; D012639:Seeds / Q000737:chemistry; D012995:Solubility; D013678:Technology, Pharmaceutical / Q000379:methods*
D000470:Alkaloids; D044182:Benzylisoquinolines; D007546:Isoquinolines; D010636:Phenols; C499779:isoliensinine; C057222:neferine; C080095:liensinine; D011092:Polyethylene Glycols