title: New sphingolipids from the root of Isatis indigotica and their cytotoxic activity.
abstract: Two new sphingolipids were isolated from the 95% EtOH extract of traditional Chinese medicinal plant Isatis indigotica. Their structures were elucidated as (2S,3R)-3-hydroxymethyl-N-(2'-hydroxynonacosanoyl)-trideca-9E-sphingenine(1) and 1-O-beta-D-glucopyranosyl-(2S,3R)-3-hydroxymethyl-N-(2'-hydroxynonacosanoyl)-trideca-9E-sphingenine(2) on the basis of spectroscopic data. Their cytotoxic effects were evaluated by using MTT method.
authors.affiliation: Nanjing University of Traditional Chinese Medicine, 210029, Jiangsu, People's Republic of China. sdd.426910@163.com
authors.forename: Xiang
authors.initials: X
authors.lastname: Li
authors.forename: Dong-Dong
authors.initials: DD
authors.lastname: Sun
authors.forename: Jian-Wei
authors.initials: JW
authors.lastname: Chen
authors.forename: Li-Wei
authors.initials: LW
authors.lastname: He
authors.forename: Han-Qing
authors.initials: HQ
authors.lastname: Zhang
authors.forename: Hui-Qin
authors.initials: HQ
authors.lastname: Xu
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D045744:Cell Line, Tumor / Q000187:drug effects; D006801:Humans; D031219:Isatis; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D018517:Plant Roots; D013107:Sphingolipids / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D013329:Structure-Activity Relationship
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D013107:Sphingolipids