title: Cell metabolism of acyclovir phosphonate derivatives and antiherpesvirus activity of their combinations with alpha2-interferon.
abstract: The combinational use of acyclovir (ACV) phosphonate esters and alpha(2)-interferon was shown to produce a synergistic effect on inhibition of HSV-1 replication in Vero cell cultures. Unlike other acyclovir phosphonate derivatives studied earlier, ACV H-phosphonate is not an ACV prodrug. On penetrating into the cells, it may be directly converted into ACV monophosphate escaping dephosphonylation-phosphorylation steps.
authors.affiliation: Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 32 Vavilov str., Moscow 119991, Russian Federation. ihba-imb@mail.ru
authors.forename: Yuri S
authors.initials: YS
authors.lastname: Skoblov
authors.forename: Inna L
authors.initials: IL
authors.lastname: Karpenko
authors.forename: Maxim V
authors.initials: MV
authors.lastname: Jasko
authors.forename: Marina K
authors.initials: MK
authors.lastname: Kukhanova
authors.forename: Valery L
authors.initials: VL
authors.lastname: Andronova
authors.forename: Georgy A
authors.initials: GA
authors.lastname: Galegov
authors.forename: Georgy V
authors.initials: GV
authors.lastname: Sidorov
authors.forename: Nicolai F
authors.initials: NF
authors.lastname: Myasoedov
mesh_terms: D000212:Acyclovir / Q000031:analogs & derivatives* / Q000737:chemistry; D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D002522:Chlorocebus aethiops; D002845:Chromatography / Q000379:methods; D015195:Drug Design; D006564:Herpesviridae / Q000378:metabolism*; D016898:Interferon-alpha / Q000378:metabolism*; D007700:Kinetics; D008954:Models, Biological; D063065:Organophosphonates / Q000737:chemistry*; D010766:Phosphorylation; D011683:Purine-Nucleoside Phosphorylase / Q000737:chemistry; D014709:Vero Cells
chemical_list: D000998:Antiviral Agents; D016898:Interferon-alpha; D063065:Organophosphonates; C026145:acyclovir monophosphate; D011683:Purine-Nucleoside Phosphorylase; D000212:Acyclovir