Chronic lymphocytic leukemia with a monoclonal immunoglobulin M lambda lymphocyte agglutinin.
A case of chronic lymphocytic leukemia is described in which peripheral blood films showed lymphocyte agglutination. A serum factor responsible for the agglutination was demonstrated. The factor was dependent upon the presence of anticoagulant solutions and was more active at room temperature than at 37 degrees C. It could be identified as a monoclonal immunoglobulin M. This mechanism has not been previously described in lymphocyte agglutination.
Orero
M
M
Department of Hematology, Consorcio Hospital General, Valencia, Spain. orero_may@gva.es
Collado
R
R
Pérez
P L
PL
Pacios
A
A
Iglesias
R
R
Martínez
A
A
Miguel-Sosa
A
A
Carbonell
F
F
D000369:Aged, 80 and over; D000371:Agglutination / Q000187:drug effects; D000372:Agglutination Tests; D000373:Agglutinins / Q000097:blood*; D000911:Antibodies, Monoclonal / Q000097:blood* / Q000494:pharmacology; D000925:Anticoagulants / Q000494:pharmacology; D016175:B-Lymphocyte Subsets / Q000276:immunology / Q000473:pathology; D004492:Edetic Acid / Q000494:pharmacology; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood*; D007146:Immunoglobulin lambda-Chains / Q000097:blood*; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000097:blood*; D007962:Leukocytes; D008214:Lymphocytes; D008297:Male; D009363:Neoplasm Proteins / Q000097:blood*; D014411:Neoplastic Stem Cells / Q000276:immunology / Q000473:pathology; D011506:Proteins / Q000032:analysis
D000373:Agglutinins; D000911:Antibodies, Monoclonal; D000925:Anticoagulants; D007075:Immunoglobulin M; D007146:Immunoglobulin lambda-Chains; D009363:Neoplasm Proteins; D011506:Proteins; C100155:leukoagglutinins, leukocytes; D004492:Edetic Acid