title: Evaluation of myorelaxant activity of 7-substituted hexahydroquinoline derivatives in isolated rabbit gastric fundus.
abstract: In this article, 16 new methyl(ethyl) 4-(dichlorophenyl)-2,7-dimethyl-5-oxo-l,4,5,6,7,8-hexahydroquinoline-3-carboxylates and methyl(ethyl) 2-methyl-4-(dichlorophenyl)-5-oxo-7-phenyl-l,4,5,6,7,8-hexahydroquinoline-3-carboxylate derivatives have been synthesized by the Hantzsch reaction and screened for their myorelaxant and potassium channel opening activities. The maximum relaxant effects (E(max)) and pD(2) values on exogenous noradrenaline precontracted tissues and inhibitory effects on cholinergic neurotransmission of the compounds and pinacidil were determined on isolated strips of rabbit gastric fundus smooth muscle. Obtained results indicated that some compounds and pinacidil produced concentration-dependent relaxation on rabbit gastric fundus smooth muscle strips in the two test conditions.
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hacettepe University, 06100 Ankara, Turkey.
authors.forename: Miyase Gözde
authors.initials: MG
authors.lastname: Gündüz
authors.forename: Gökçe
authors.initials: G
authors.lastname: Sevim Oztürk
authors.forename: Ismail Mert
authors.initials: IM
authors.lastname: Vural
authors.forename: Rahime
authors.initials: R
authors.lastname: Simşek
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Sarioğlu
authors.forename: Cihat
authors.initials: C
authors.lastname: Safak
mesh_terms: D000818:Animals; D004353:Drug Evaluation, Preclinical; D005748:Gastric Fundus / Q000187:drug effects* / Q000502:physiology*; D066298:In Vitro Techniques; D009126:Muscle Relaxation / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology; D009638:Norepinephrine / Q000494:pharmacology; D020110:Pinacidil / Q000494:pharmacology; D011804:Quinolines / Q000737:chemistry / Q000494:pharmacology*; D011817:Rabbits
chemical_list: D011804:Quinolines; D020110:Pinacidil; D009638:Norepinephrine