The hematopoietic niche: a Drosophila model, at last.
The niche provides a specialised microenvironment necessary for maintenance of stem cells in a non differentiated state. While the hematopoietic stem cell (HSC) niche in vertebrates was the first to be recognized, Drosophila niches supporting germline stem cells were characterised first. Recent evidence for the existence of a niche maintaining hematopoietic precursors in Drosophila opens the way to study in vivo the niche/hematopoietic precursors interactions. The availability of a large collection of cell markers, mutants and sophisticated genetic tools makes Drosophila an attractive model for investigating the cellular and molecular mechanisms that are involved in these interactions.
Crozatier
Michèle
M
Centre de Biologie du Développement, Université Paul Sabatier, Toulouse, France. crozat@cict.fr
Krzemien
Joanna
J
Vincent
Alain
A
D000818:Animals; D015415:Biomarkers; D002135:Calcium-Binding Proteins / Q000378:metabolism; D004330:Drosophila / Q000166:cytology*; D029721:Drosophila Proteins / Q000378:metabolism; D006412:Hematopoietic Stem Cells / Q000502:physiology*; D006434:Hemocytes / Q000502:physiology*; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism; D000072100:Jagged-1 Protein; D007814:Larva / Q000166:cytology; D008565:Membrane Proteins / Q000378:metabolism; D023421:Models, Animal; D000072099:Serrate-Jagged Proteins; D014157:Transcription Factors / Q000378:metabolism
D015415:Biomarkers; D002135:Calcium-Binding Proteins; D029721:Drosophila Proteins; D036341:Intercellular Signaling Peptides and Proteins; D000072100:Jagged-1 Protein; D008565:Membrane Proteins; C000606278:Ser protein, Drosophila; D000072099:Serrate-Jagged Proteins; D014157:Transcription Factors; C104357:kn protein, Drosophila