Chemotherapy-induced resistance by ATP-binding cassette transporter genes.
A key issue in the treatment of many cancers is the development of resistance to chemotherapeutic drugs. Resistance mechanisms are numerous and complex. One of them is mediated by the overexpression of ATP-binding cassette (ABC) transporters able to efflux drugs out of the tumor cell. The last two decades have seen notable growth of knowledge concerning the involvement of ABC transporters in resistance to chemotherapy. This review emphasizes these transporters, their clinical relevance and the diagnostic methods and strategies to circumvent multidrug resistance (MDR) mediated by ABC transporters.
Gillet
Jean-Pierre
JP
Department of Biology, University of Namur, 61 rue de Bruxelles, 5000 Namur, Belgium. gilletjp@mail.nih.gov
Efferth
Thomas
T
Remacle
José
J
D018528:ATP-Binding Cassette Transporters / Q000737:chemistry / Q000145:classification / Q000235:genetics*; D000970:Antineoplastic Agents / Q000009:adverse effects*; D018360:Crystallography, X-Ray; D004351:Drug Resistance; D015316:Genetic Therapy; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy / Q000235:genetics; D011487:Protein Conformation; D013234:Stem Cells / Q000502:physiology
D018528:ATP-Binding Cassette Transporters; D000970:Antineoplastic Agents