title: Neuromuscular junction in health and disease.
abstract: A number of illnesses and other factors can affect the function of the neuromuscular junction (NMJ). These may have an affect at pre- or post-junctional sites. This review outlines the anatomy and the physiology of the NMJ. It also describes the mechanisms and physiological basis of many of the disorders of the NMJ. Finally, the importance of these disorders in anaesthetic practice is discussed.
authors.affiliation: The National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK. nicholas.hirsch@uclh.nhs.uk
authors.forename: N P
authors.initials: NP
authors.lastname: Hirsch
mesh_terms: D000758:Anesthesia / Q000379:methods*; D006801:Humans; D009157:Myasthenia Gravis / Q000150:complications / Q000503:physiopathology; D009466:Neuromuscular Blocking Agents / Q000494:pharmacology; D009469:Neuromuscular Junction / Q000033:anatomy & histology / Q000502:physiology*; D020511:Neuromuscular Junction Diseases / Q000150:complications* / Q000503:physiopathology; D019990:Perioperative Care / Q000379:methods
chemical_list: D009466:Neuromuscular Blocking Agents