Gantrez AN nanoparticles as an adjuvant for oral immunotherapy with allergens.
The aim of this study was to investigate the adjuvant properties of oral-administered Gantrez AN nanoparticles with ovalbumin (as allergen model) and, in some cases, lipopolysaccharide of Brucella ovis as immunomodulator. For this purpose, BALB/c mice were administered by oral gavage with OVA nanoparticles and both Th1 and Th2 markers (IgG2a and IgG1, respectively) were enhanced. On the other hand, these carriers administered by oral route were able to protect a model of sensitized mice to ovalbumin from anaphylactic shock. These results are highly suggestive for the valuable use of Gantrez nanoparticles in oral immunotherapy with allergens.
Gómez
Sara
S
Adjuvant Unit, Department of Pharmaceutical Technology and Microbiology, University of Navarra, 31080 Pamplona, Spain.
Gamazo
Carlos
C
Roman
Beatriz San
BS
Ferrer
Marta
M
Sanz
Maria Luisa
ML
Irache
Juan M
JM
D000276:Adjuvants, Immunologic / Q000008:administration & dosage*; D000284:Administration, Oral; D000485:Allergens / Q000276:immunology*; D000707:Anaphylaxis / Q000517:prevention & control; D000818:Animals; D042061:Brucella ovis / Q000276:immunology; D004195:Disease Models, Animal; D005260:Female; D007074:Immunoglobulin G / Q000097:blood; D007167:Immunotherapy / Q000379:methods*; D008298:Maleates / Q000008:administration & dosage / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D053758:Nanoparticles; D010047:Ovalbumin / Q000276:immunology; D011135:Polysaccharides, Bacterial / Q000276:immunology; D011145:Polyvinyls / Q000008:administration & dosage
D000276:Adjuvants, Immunologic; D000485:Allergens; D007074:Immunoglobulin G; D008298:Maleates; D011135:Polysaccharides, Bacterial; D011145:Polyvinyls; C058026:polyvinylmethoxyethylene-maleic anhydride copolymer; D010047:Ovalbumin