title: Prediction of multi-locus inbreeding coefficients and relation to linkage disequilibrium in random mating populations.
abstract: An algorithm to predict the level of identity by descent simultaneously at multiple loci is presented, which can in principle be extended to any number of loci. The model assumes a random mating population, with random association of haplotypes. The relationship is shown between coefficients of multi-locus identity or non-identity by descent and moments of multi-locus linkage disequilibrium. Thus, these moments can be computed from the multilocus identity or, using algorithms derived previously to predict the disequilibria moments, vice-versa. The results can be applied to predict multi-locus identity in, for example, gene mapping.
authors.affiliation: Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, West Mains Road, Edinburgh, EH9 3JT, UK. w.g.hill@ed.ac.uk
authors.forename: William G
authors.initials: WG
authors.lastname: Hill
authors.forename: Bruce S
authors.initials: BS
authors.lastname: Weir
mesh_terms: D000465:Algorithms; D003241:Consanguinity; D005544:Forecasting; D008040:Genetic Linkage; D005828:Genetics, Population; D006801:Humans; D011157:Population Dynamics