Architecture and dynamics of the transcription factor network that regulates B-to-plasma cell differentiation.
Upon antigen stimulation, B lymphoid cells undergo terminal differentiation into antibody-secreting plasma cells. This process accompanies drastic changes in cell functions such as a loss of B-cell identity, induction of secretory apparatus, and an extremely increased transcription of antibody genes. These changes are the result of re-wiring of a transcription factor network in B and plasma cells. While the transcription repressor Blimp-1 induces plasma cell differentiation, another repressor Bach2 has emerged as a negative regulator of Blimp-1 in B cells. These two transcription factors, together with other several factors, appear to constitute a main transcriptional regulatory network for the terminal differentiation process of plasma cells from B cells.
Igarashi
Kazuhiko
K
Department of Biochemistry, Tohoku University Graduate School of Medicine, Seiryo-machi 2-1, Sendai 980-8575, Japan. igarak@mail.tains.tohoku.ac.jp
Ochiai
Kyoko
K
Muto
Akihiko
A
D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology* / Q000378:metabolism; D002454:Cell Differentiation; D045744:Cell Line, Tumor; D006801:Humans; D008954:Models, Biological; D009154:Mutation; D010950:Plasma Cells / Q000166:cytology* / Q000378:metabolism; D000074462:Positive Regulatory Domain I-Binding Factor 1; D011995:Recombination, Genetic; D012097:Repressor Proteins / Q000502:physiology*; D014157:Transcription Factors / Q000378:metabolism / Q000502:physiology*; D014158:Transcription, Genetic
D012097:Repressor Proteins; D014157:Transcription Factors; C087042:PRDM1 protein, human; D000074462:Positive Regulatory Domain I-Binding Factor 1