title: Ubiquitination without E3.
abstract: In the current issue of Molecular Cell, Hoeller et al. (2007) demonstrated that proteins bearing ubiquitin-binding domains (UBDs) can be ubiquitinated directly by E2-conjugating enzymes, bypassing the requirement for E3 ubiquitin ligases.
authors.affiliation: Department of Pharmacology, University of Colorado Health Sciences Center, Aurora, CO 80045, USA. alexander.sorkin@uchsc.edu
authors.forename: Alexander
authors.initials: A
authors.lastname: Sorkin
mesh_terms: D031541:Fluorescence Resonance Energy Transfer; D006367:HeLa Cells; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000494:pharmacology; D011485:Protein Binding / Q000187:drug effects / Q000502:physiology; D011499:Protein Processing, Post-Translational / Q000187:drug effects / Q000502:physiology*; D034741:RNA, Small Interfering / Q000235:genetics / Q000494:pharmacology; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology*; D025801:Ubiquitin / Q000378:metabolism*; D044764:Ubiquitin-Activating Enzymes / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D044767:Ubiquitin-Protein Ligases
chemical_list: D036341:Intercellular Signaling Peptides and Proteins; D034741:RNA, Small Interfering; D025801:Ubiquitin; D044767:Ubiquitin-Protein Ligases; D044764:Ubiquitin-Activating Enzymes