title: Gestational choriocarcinoma arising from a cornual ectopic pregnancy: a case report and review of the literature.
abstract: BACKGROUND
  Gestational choriocarcinoma associated with ectopic pregnancy is an extremely rare event. We report a case of a choriocarcinoma arising from a cornual pregnancy.
  
  
  METHODS
  The patient is a 35-year-old G8 P2052 who was referred to our department due to failure of treatment for a suspected ectopic pregnancy. The patient had initially been treated with methotrexate injection but her beta-hCG levels reached a plateau 3 weeks later and, despite another two methotrexate injections, started to rise. The patient underwent dilation and curettage that did not reveal any trophoblastic tissue. A diagnostic hysteroscopy that followed demonstrated occluded ostia of the left tube. The patient subsequently underwent diagnostic laparoscopy that revealed a mass in the left cornua, which was removed with wedge-wide resection. Histologic evaluation revealed choriocaricnoma.
  
  
  CONCLUSIONS
  Appropriate monitoring of beta-hCG titers following conservative management of suspected ectopic pregnancy is important, not only to diagnose persistent ectopic gestation, but also to rule out the presence of malignant trophoblastic disease, albeit the latter is a rare diagnosis.
authors.affiliation: Department of Obstetrics and Gynecology, Maimonides Medical Center, Brooklyn, NY 11219, USA. mrotas@gmail.com
authors.forename: Michael
authors.initials: M
authors.lastname: Rotas
authors.forename: Neekinaund
authors.initials: N
authors.lastname: Khulpateea
authors.forename: David
authors.initials: D
authors.lastname: Binder
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D002822:Choriocarcinoma / Q000188:drug therapy / Q000209:etiology* / Q000601:surgery; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000097:blood; D005185:Fallopian Tube Neoplasms / Q000188:drug therapy / Q000209:etiology* / Q000601:surgery; D005260:Female; D006801:Humans; D002955:Leucovorin / Q000008:administration & dosage; D008727:Methotrexate / Q000008:administration & dosage; D011247:Pregnancy; D011271:Pregnancy, Ectopic / Q000503:physiopathology*
chemical_list: D018997:Chorionic Gonadotropin, beta Subunit, Human; D002955:Leucovorin; D008727:Methotrexate