Predicting memory: a prospective readout for malaria vaccines?
Malaria vaccines aim to induce long lasting protective immunity. Bejon and colleagues propose that levels of rapidly induced (effector memory) interleukin-2 and interferon gamma producing T-cells after vaccination with leading pre-erythrocytic stage vaccines predict the induction of resting memory responses (central memory). Herein we discuss Bejon's findings in the context of current thinking on the generation and maintenance of T cell memory, with particular emphasis on the role of cytokines.
Minigo
Gabriela
G
Department of Immunology, Monash University, The Alfred Medical Research and Education Precinct, Prahran, Victoria 3181, Australia.
Scalzo
Karen
K
Flanagan
Katie L
KL
Plebanski
Magdalena
M
D000818:Animals; D006801:Humans; D007156:Immunologic Memory; D007371:Interferon-gamma / Q000096:biosynthesis* / Q000276:immunology; D007376:Interleukin-2 / Q000096:biosynthesis* / Q000276:immunology; D008288:Malaria / Q000276:immunology* / Q000517:prevention & control; D017780:Malaria Vaccines / Q000276:immunology*; D010961:Plasmodium / Q000276:immunology*; D011237:Predictive Value of Tests; D013997:Time Factors
D007376:Interleukin-2; D017780:Malaria Vaccines; D007371:Interferon-gamma