title: Hand coordination as a quantitative measure of motor abnormality and therapeutic response in Parkinson's disease.
abstract: OBJECTIVE
  The precision grip-and-lift task (PGLT) has been used to measure hand motor coordination in PD. We designed this study to investigate if the PGLT outcome variables correlate with the UPDRS motor scores and if all PGLT outcome variables are "responsive" to levodopa.
  
  
  METHODS
  We used PGLT to assess hand motor coordination in 10 PD and 10 normal controls before and after levodopa.
  
  
  RESULTS
  Factor analysis showed that the six PGLT parameters were reduced to two factors, a levodopa-responsive factor and a dopa-resistant factor that explained 74% of the total variance. The levodopa-responsive factor, which correlated significantly with "off" UPDRS motor scores, includes load preparation time, maximum vertical acceleration, maximum grip velocity and maximum grip force. The levodopa-resistant factor, which did not correlate with "off" UPDRS motor scores, included maximum negative load force and tremor during lift. Both dopa-responsive and dopa-resistant factors were altered in PD compared to controls before levodopa. Levodopa improved dopa-responsive, but not dopa-resistant factor in PD.
  
  
  CONCLUSIONS
  PGLT can measure two aspects of fine motor performance, both affected by PD but differentially affected by levodopa.
  
  
  CONCLUSIONS
  PGLT can be useful in characterizing the response of motor abnormality in PD therapeutic trials.
authors.affiliation: Department of Neurology, CR-120, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR, United States.
authors.forename: Ted S
authors.initials: TS
authors.lastname: Benice
authors.forename: Jau-Shin
authors.initials: JS
authors.lastname: Lou
authors.forename: Ryan
authors.initials: R
authors.lastname: Eaton
authors.forename: John
authors.initials: J
authors.lastname: Nutt
mesh_terms: D000368:Aged; D000978:Antiparkinson Agents / Q000627:therapeutic use*; D005163:Factor Analysis, Statistical; D005260:Female; D006225:Hand / Q000503:physiopathology*; D018737:Hand Strength; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology*; D011597:Psychomotor Performance; D012720:Severity of Illness Index; D014891:Weight Lifting
chemical_list: D000978:Antiparkinson Agents; D007980:Levodopa