Susceptibility of human enterotoxigenic Escherichia coli isolates to growth inhibition by porcine intestinal epithelial cells.
Growth of human, but not porcine enterotoxigenic Escherichia coli (ETEC) isolates is inhibited during incubation with porcine intestinal epithelial cells and by a constitutively produced factor(s) present in unstimulated cell supernatants. The inhibitory factor(s) is heat stable, not produced by serum-starved cells, and is present in a diverse number of cultured epithelial cell lines of animal, but not of human origin. Susceptibility to porcine intestinal epithelial cells appears to be restricted to ETEC and not E. coli O157:H7 disease isolates.
Brown
Eric A
EA
Center for Infectious Disease Research and Vaccinology, South Dakota State University, Brookings, SD 57007, USA.
Kaushik
Radhey S
RS
Hardwidge
Philip R
PR
D000818:Animals; D001422:Bacterial Adhesion; D001685:Biological Factors / Q000494:pharmacology*; D002460:Cell Line; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development* / Q000302:isolation & purification; D006801:Humans; D007413:Intestinal Mucosa / Q000166:cytology / Q000382:microbiology*; D008826:Microbial Sensitivity Tests; D013552:Swine / Q000382:microbiology*
D001685:Biological Factors