title: Gravin gene expression in acute leukaemias: clinical importance and review of the literature.
abstract: The aim of this study was to determine the expression of Gravin (a tumor suppressor gene belonging to the A kinase anchoring protein family) in samples of acute leukaemia and to explore its association with the prognosis. The study group consisted of 162 people (137 patients with acute leukaemia and 25 volunteers as control). Real-time quantitative PCR was used to determine the gene expression and beta Actin used as a control gene. The results were evaluated with Comparative Ct method. Gravin beta-Actin DeltaCt was statistically different between patients and controls (p value < 0.001). The Gravin expression was found to be decreased 11-fold when compared with controls and was found to be decreased in 106 cases (77.5%). There was an inverse correlation between gravin expression and overall survival. The Gravin expression was found to be decreased in samples of acute leukaemia and was associated with an inferior overall survival. Because of paradoxical results, there is a need for more studies exploring gravin isoforms and other related gene expressions.
authors.affiliation: Department of Oncology, Cukurova University Faculty of Medicine, Cukurova University, Adana, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Yildirim
authors.forename: Semra
authors.initials: S
authors.lastname: Paydas
authors.forename: Kahraman
authors.initials: K
authors.lastname: Tanriverdi
authors.forename: Gulsah
authors.initials: G
authors.lastname: Seydaoglu
authors.forename: Umut
authors.initials: U
authors.lastname: Disel
authors.forename: Sinan
authors.initials: S
authors.lastname: Yavuz
mesh_terms: D054758:A Kinase Anchor Proteins / Q000235:genetics*; D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000235:genetics; D016022:Case-Control Studies; D018797:Cell Cycle Proteins / Q000235:genetics*; D015870:Gene Expression; D006801:Humans; D007951:Leukemia, Myeloid / Q000175:diagnosis / Q000235:genetics* / Q000401:mortality; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis / Q000235:genetics* / Q000401:mortality; D011379:Prognosis; D016019:Survival Analysis
chemical_list: D054758:A Kinase Anchor Proteins; C491162:AKAP12 protein, human; D014408:Biomarkers, Tumor; D018797:Cell Cycle Proteins