[Effects of hand hygiene on feline calicivirus inactivation and removal as norovirus surrogate treated with antiseptic hand rubbing, wet wipes, and functional water].
As a preventive action plan against gastroenteritis caused by the Norovirus (NV), we studied hand hygiene effects using with three hand rubbing products, four wet wipe products, and two functional water types using Feline Calicivirus as a Norovirus surrogate. After treatment using antiseptic hand rubbing products containing chlorhexidine, quaternary ammonium, and povidone-iodine, high inactivation detected by TCID50 was observed compared to products containing povidone-iodine, although no difference was seen in viral removal measured by the amount of viral genome copies in real-time-PCR. Among wet wipes soaked in chlorhexidine, quaternary ammonium, benzoic acid and PHMB, two groups showed viral inactivation and removal. Two products were more effective for functional water, viral decrease was seen in rinsing in running electrolyzed acid water and handwashing by soap. Results underscore the importance of selection in hand washing metheds (alternative soap and also) in preventing viral gastroenteritis.
Mori
Kohji
K
Department of Microbiology, Tokyo Metropolitan Institute of Public Health.
Hayashi
Yukinao
Y
Akiba
Tetsuya
T
Noguchi
Yayoi
Y
Yoshida
Yasuko
Y
Kai
Akemi
A
Yamada
Sumio
S
Sakai
Sachi
S
Hara
Motonobu
M
D000891:Anti-Infective Agents, Local / Q000494:pharmacology*; D019817:Benzoic Acid / Q000494:pharmacology; D017927:Calicivirus, Feline / Q000187:drug effects*; D002710:Chlorhexidine / Q000494:pharmacology; D006225:Hand / Q000821:virology*; D006235:Hand Disinfection / Q000379:methods; D006801:Humans; D006902:Hydroxymercuribenzoates / Q000494:pharmacology; D029322:Norovirus / Q000187:drug effects*; D011206:Povidone-Iodine / Q000494:pharmacology; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology; D038301:Virus Inactivation
D000891:Anti-Infective Agents, Local; D006902:Hydroxymercuribenzoates; D000644:Quaternary Ammonium Compounds; C030601:4-hydroxymercuribenzoate; D011206:Povidone-Iodine; D019817:Benzoic Acid; D002710:Chlorhexidine