Genetic influences on the arterial wall.
1. Arterial stiffness, which has independent predictive value for cardiovascular events, seems to have a genetic component, largely independent of the influence of blood pressure and other cardiovascular risk factors. 2. In animal models of essential hypertension (stroke-prone spontaneously hypertensive rats and spontaneously hypertensive rats), structural modifications of the arterial wall include an increase in the number of elastin-smooth muscle cell connections and smaller fenestrations of the internal elastic lamina, possibility leading to redistribution of the mechanical load towards elastic materials. These modifications may give rise to mechanisms explaining why changes in arterial wall material accompanying wall hypertrophy in these animals are not associated with an increase in arterial stiffness. 3. In monogenic connective tissue diseases (Marfan, Williams and Ehlers-Danlos syndromes) and the corresponding animal models, precise characterization of the arterial phenotype makes it possible to determine the influence of abnormal, genetically determined, wall components on arterial stiffness. 4. Such studies have highlighted the role of extracellular matrix signalling in the vascular wall and have shown that elastin and collagen not only display elasticity or rigidity, but are also involved in the control of smooth muscle cell function. 5. These data provide strong evidence that arterial stiffness is affected by the amount and density of stiff wall material and the spatial organization of that material.
Kingwell
Bronwyn
B
Department of Pharmacology and INSERM U652, Hôpital Européen Georges, Pompidou, Université Paris-Descartes, Faculté de Médecine, Paris, France.
Boutouyrie
Pierre
P
D000818:Animals; D001158:Arteries / Q000473:pathology* / Q000503:physiopathology; D002318:Cardiovascular Diseases / Q000175:diagnosis / Q000235:genetics* / Q000503:physiopathology; D003094:Collagen / Q000235:genetics; D003187:Compliance; D004195:Disease Models, Animal; D004535:Ehlers-Danlos Syndrome / Q000235:genetics / Q000473:pathology; D004549:Elastin / Q000235:genetics; D005109:Extracellular Matrix / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D020869:Gene Expression Profiling / Q000379:methods; D020022:Genetic Predisposition to Disease; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology; D008382:Marfan Syndrome / Q000235:genetics / Q000473:pathology; D020411:Oligonucleotide Array Sequence Analysis; D011110:Polymorphism, Genetic; D012307:Risk Factors; D017539:Tunica Intima / Q000473:pathology; D017540:Tunica Media / Q000473:pathology; D018980:Williams Syndrome / Q000235:genetics / Q000473:pathology
D003094:Collagen; D004549:Elastin