title: Practical action levels for chelation therapy in plutonium inhalation using nose swab.
abstract: The aim of this study is to propose action levels for chelation therapy in the case of inhalation of plutonium compounds using nose swabs. The relationship between the activity found in the nose swabs and early faecal excretion was investigated using actual cases at JAEA-NFCEL. The ratio was found to be in log-normal distribution. The action levels based on the activity of nose swab corresponding to 10 ALI (=200 mSv) are determined for the facilities at JAEA-NFCEL by using the relationship and specific information such as isotopic ratio and physicochemical characteristics of plutonium compounds.
authors.affiliation: Japan Atomic Energy Agency, 4-33 Muramatsu, Tokai-mura, Ibaraki 319-1194, Japan. osakuri@nirs.go.jp
authors.forename: O
authors.initials: O
authors.lastname: Kurihara
authors.forename: C
authors.initials: C
authors.lastname: Takada
authors.forename: K
authors.initials: K
authors.lastname: Takasaki
authors.forename: K
authors.initials: K
authors.lastname: Ito
authors.forename: T
authors.initials: T
authors.lastname: Momose
authors.forename: K
authors.initials: K
authors.lastname: Miyabe
mesh_terms: D001681:Biological Assay / Q000379:methods*; D001822:Body Burden; D002614:Chelating Agents / Q000627:therapeutic use*; D003198:Computer Simulation; D006801:Humans; D008452:Maximum Allowable Concentration; D008954:Models, Biological; D009297:Nasal Mucosa / Q000378:metabolism*; D011005:Plutonium / Q000008:administration & dosage* / Q000493:pharmacokinetics* / Q000633:toxicity; D011829:Radiation Dosage; D011832:Radiation Injuries / Q000209:etiology / Q000517:prevention & control*; D011874:Radiometry / Q000379:methods*; D012062:Relative Biological Effectiveness; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D002614:Chelating Agents; D011005:Plutonium