Three cases of cytomegalovirus infection following pancreatic islet transplantation.
Transmission of cytomegalovirus (CMV) is uncommon in patients transplanted with CMV-mismatched pancreatic islets, and CMV-seropositive recipients rarely experience reactivation of the virus or reinfection from a CMV-positive graft. This study describes three cases of CMV infection following islet transplantation for type 1 diabetes despite prophylaxis with valganciclovir. Further studies are needed to evaluate risk factors for CMV transmission and reactivation in this patient population.
Yakubovich
N
N
Division of Endocrinology, University of British Columbia, Vancouver, Canada.
Fung
M A
MA
Thompson
D M
DM
D000998:Antiviral Agents / Q000627:therapeutic use; D003586:Cytomegalovirus Infections / Q000175:diagnosis* / Q000188:drug therapy / Q000517:prevention & control / Q000635:transmission; D015774:Ganciclovir / Q000627:therapeutic use; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D016381:Islets of Langerhans Transplantation / Q000009:adverse effects*; D012008:Recurrence
D000998:Antiviral Agents; D016756:Immunoglobulins, Intravenous; D015774:Ganciclovir