Systemic inflammation in patients with chronic obstructive pulmonary disease who are colonized with Pneumocystis jiroveci.
In chronic obstructive pulmonary disease, high levels of airway and systemic inflammatory markers are associated with a faster decrease in lung function. Our study shows that patients colonized by Pneumocystis jiroveci have higher proinflammatory cytokine levels than do noncolonized patients. This suggests that Pneumocystis may play a role in disease progression.
Calderón
Enrique J
EJ
Department of Internal Medicine, Virgen del Rocio University Hospital, Seville, Spain.
Rivero
Laura
L
Respaldiza
Nieves
N
Morilla
Rubén
R
Montes-Cano
Marco A
MA
Friaza
Vicente
V
Muñoz-Lobato
Fernando
F
Varela
José M
JM
Medrano
Francisco J
FJ
Horra
Carmen de la
Cde L
D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D015169:Colony Count, Microbial; D016207:Cytokines / Q000032:analysis / Q000378:metabolism; D018450:Disease Progression; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism; D008297:Male; D009894:Opportunistic Infections / Q000175:diagnosis* / Q000453:epidemiology / Q000276:immunology; D045363:Pneumocystis carinii / Q000302:isolation & purification*; D011020:Pneumonia, Pneumocystis / Q000175:diagnosis* / Q000453:epidemiology; D011379:Prognosis; D029424:Pulmonary Disease, Chronic Obstructive / Q000453:epidemiology / Q000276:immunology / Q000382:microbiology*; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index
D016207:Cytokines; D018836:Inflammation Mediators