title: Effect of left ventricular shape alteration on contractility and function.
abstract: We have investigated the effect of left ventricular (LV) shape on contractility and ejection function. In this study, a new contractility index is developed in terms of the wall stress (sigma*, normalized with respect to LV pressure) by means of an LV ellipsoidal model. Using cine-ventriculography data, the LV ellipsoidal model (LVEM) major (B) and minor axes (A) are derived for the entire cardiac cycle. Thereafter, a new contractility index (CONT1) is derived as dsigma*/dt, incorporating the LV ellipsoidal shape factor. Also, another contractility index (CONT2) was developed in terms of the generated sigma* at the start of ejection phase, and maximized with respect to B/Ashape parameter, to obtain the optimal value of B/Aover the physiological ranges of the ratio of myocardial volume and LV volume. The in vivovalue of B/Aat the start of ejection is compared with this optimal value, and the LV contractility is evaluated in terms of the proximity of the in vivo B/Ato the optimal B/A. The results indicate that a non-optimal less-ellipsoidal shape (or more spherical) is associated with decreased contractility (and poor systolic function) of the LV, associated with a failing heart.
authors.affiliation: School of Mechanical and Production Engineering, College of Engineering, Nanyang Technological University, Nanyang Avenue, Republic of Singapore.
authors.forename: L
authors.initials: L
authors.lastname: Zhong
authors.forename: D N
authors.initials: DN
authors.lastname: Ghista
authors.forename: E Y K
authors.initials: EY
authors.lastname: Ng
authors.forename: S T
authors.initials: ST
authors.lastname: Lim
authors.forename: T S J
authors.initials: TS
authors.lastname: Chua
authors.forename: C N
authors.initials: CN
authors.lastname: Lee
mesh_terms: D000465:Algorithms; D001794:Blood Pressure / Q000502:physiology; D003327:Coronary Disease / Q000503:physiopathology; D006321:Heart / Q000033:anatomy & histology / Q000502:physiology* / Q000503:physiopathology; D006801:Humans; D008954:Models, Biological; D009200:Myocardial Contraction / Q000502:physiology*; D013314:Stress, Mechanical; D016277:Ventricular Function, Left / Q000502:physiology*