title: Antidiabetic activities of chalcones isolated from a Japanese Herb, Angelica keiskei.
abstract: Diabetes mellitus is a chronic disease that is characterized by hyperglycemia caused by insufficient insulin action. We have explored the edible ingredients from folk medicines in Japan that contain substances complementing insulin action, such as the induction of adipocyte differentiation and the enhancement of glucose uptake. We eventually found that the ethanol extract from a Japanese herb "Ashitaba", Angelica keiskei, contained two major chalcones of 4-hydroxyderricin (4-HD) and xanthoangelol that showed strong insulin-like activities via a pathway independent of the peroxisome proliferator-activated receptor-gamma activation. The 4-HD especially showed the preventive effects on the progression of diabetes in genetically diabetic KK-Ay mice.
authors.affiliation: Biotechnology Research Laboratories, Takara Bio Inc., 3-4-1 Seta, Otsu, Shiga, 520-2193, Japan. enokit@takara-bio.co.jp
authors.forename: Tatsuji
authors.initials: T
authors.lastname: Enoki
authors.forename: Hiromu
authors.initials: H
authors.lastname: Ohnogi
authors.forename: Kinuko
authors.initials: K
authors.lastname: Nagamine
authors.forename: Yoko
authors.initials: Y
authors.lastname: Kudo
authors.forename: Katsumi
authors.initials: K
authors.lastname: Sugiyama
authors.forename: Masashige
authors.initials: M
authors.lastname: Tanabe
authors.forename: Eiji
authors.initials: E
authors.lastname: Kobayashi
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Sagawa
authors.forename: Ikunoshin
authors.initials: I
authors.lastname: Kato
mesh_terms: D029969:Angelica / Q000737:chemistry*; D000818:Animals; D047188:Chalcones / Q000302:isolation & purification* / Q000627:therapeutic use*; D003920:Diabetes Mellitus / Q000517:prevention & control; D007004:Hypoglycemic Agents / Q000302:isolation & purification* / Q000627:therapeutic use*; D007328:Insulin / Q000494:pharmacology; D008297:Male; D051379:Mice; D047495:PPAR gamma / Q000187:drug effects; D010936:Plant Extracts / Q000737:chemistry
chemical_list: D047188:Chalcones; D007004:Hypoglycemic Agents; D007328:Insulin; D047495:PPAR gamma; D010936:Plant Extracts