title: Pregnancy-associated plasma protein-A and asthma.
abstract: Pregnancy-associated plasma protein-A (PAPP-A) is potentially a proatherosclerotic metalloproteinase and a new inflammatory marker. Investigators sought to evaluate the significance of PAPP-A in patients with asthma. Blood samples were collected from 35 patients and 20 control subjects. Serum PAPP-A was determined by enzyme-linked immunosorbent assay. PAPP-A levels of patients with asthma (8.1+/-5.0 mU/L) were higher than those of the control group (4.9+/-2.1 mU/L) (P<.01). A significant correlation was noted between serum PAPP-A concentration and asthma severity (r=.581; P<.01). Investigators concluded that PAPP-A may contribute to airway smooth muscle hyperplasia as an insulin-like growth factor-dependent insulin-like growth factor-binding protein-4 protease in patients with asthma.
authors.affiliation: Department of Clinical Biochemistry, Duzce University, School of Medicine, Duzce, Turkey. coskun_a2002@yahoo.com
authors.forename: Abdurrahman
authors.initials: A
authors.lastname: Coskun
authors.forename: Oner
authors.initials: O
authors.lastname: Balbay
authors.forename: Sadik
authors.initials: S
authors.lastname: Duran
authors.forename: Ali Nihat
authors.initials: AN
authors.lastname: Annakkaya
authors.forename: Ismet
authors.initials: I
authors.lastname: Bulut
authors.forename: Ozlem
authors.initials: O
authors.lastname: Yavuz
authors.forename: Emel
authors.initials: E
authors.lastname: Kurt
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001249:Asthma / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D002648:Child; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D018974:Insulin-Like Growth Factor Binding Protein 4 / Q000097:blood; D008297:Male; D008875:Middle Aged; D011266:Pregnancy-Associated Plasma Protein-A / Q000032:analysis*; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers; D018974:Insulin-Like Growth Factor Binding Protein 4; D011266:Pregnancy-Associated Plasma Protein-A