title: Design, synthesis, and molecular modeling studies of 5'-deoxy-5'-ureidoadenosine: 5'-ureido group as multiple hydrogen bonding donor in the active site of S-adenosylhomocysteine hydrolase.
abstract: 5'-Deoxy-5'-ureidoadenosine was designed and synthesized as a potent inhibitor of S-adenosylhomocysteine hydrolase (SAH), in which 5'-ureido group acted as multiple hydrogen bonding donor in binding with active site residues of SAH in the molecular modeling study.
authors.affiliation: Laboratory of Medicinal Chemistry, College of Pharmacy, Ewha Womans University, Seoul 120-750, Republic of Korea.
authors.forename: Ting
authors.initials: T
authors.lastname: Wang
authors.forename: Hyun Joo
authors.initials: HJ
authors.lastname: Lee
authors.forename: Dilip K
authors.initials: DK
authors.lastname: Tosh
authors.forename: Hea Ok
authors.initials: HO
authors.lastname: Kim
authors.forename: Shantanu
authors.initials: S
authors.lastname: Pal
authors.forename: Sun
authors.initials: S
authors.lastname: Choi
authors.forename: Yoonji
authors.initials: Y
authors.lastname: Lee
authors.forename: Hyung Ryong
authors.initials: HR
authors.lastname: Moon
authors.forename: Long Xuan
authors.initials: LX
authors.lastname: Zhao
authors.forename: Kang Man
authors.initials: KM
authors.lastname: Lee
authors.forename: Lak Shin
authors.initials: LS
authors.lastname: Jeong
mesh_terms: D043383:Adenosylhomocysteinase / Q000737:chemistry / Q000378:metabolism*; D001665:Binding Sites; D003839:Deoxyadenosines / Q000138:chemical synthesis / Q000737:chemistry*; D015195:Drug Design; D006860:Hydrogen Bonding; D008958:Models, Molecular; D015394:Molecular Structure; D013329:Structure-Activity Relationship
chemical_list: C524172:5'-deoxy-5'-ureidoadenosine; D003839:Deoxyadenosines; D043383:Adenosylhomocysteinase