[Effects of norepinephrine on brain oxygen saturation].
BACKGROUND
In carotid endarterectomy (CEA), it is essential to maintain the systemic blood pressure (BP) and cerebral perfusion pressure, especially during cross clamping, and vasopressors are often required. To elucidate the effect of norepinephrine (NE) on the cerebral circulation in patients undergoing CEA, regional oxygen saturation (rSO2) in bilateral frontal poles was monitored by near infrared spectroscopy during NE infusion.


METHODS
Seven patients undergoing CEA were enrolled. Bilateral frontal rSO2 was monitored with transcranial optical spectroscopy. Anesthesia was induced and maintained with propofol, fentanyl and vecuronium.


RESULTS
NE increased MAP (P<0.001) and decreased HR (P<0.001) and bilateral rSO2 (ipsilateral P<0.01, contralateral P<0.05).


CONCLUSIONS
NE used to maintain the MAP decreased the brain rSO2. NE would aggravate the balance between cerebral oxygen supply and consumption in patients undergoing CEA. Further investigations are necessary to clarify the effect of systemically administered norepinephrine on the cerebral circulation.
Sato
Kiyotaka
K
Department of Neuroanesthesia, Kohnan Hospital, Sendai.
Kamii
Hideyuki
H
Shimizu
Hiroaki
H
Kato
Masato
M
D000368:Aged; D000768:Anesthesia, General; D001794:Blood Pressure / Q000187:drug effects; D002560:Cerebrovascular Circulation / Q000187:drug effects; D016894:Endarterectomy, Carotid; D005625:Frontal Lobe / Q000378:metabolism*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007430:Intraoperative Care; D008297:Male; D008875:Middle Aged; D016343:Monitoring, Intraoperative; D009638:Norepinephrine / Q000008:administration & dosage / Q000494:pharmacology*; D010101:Oxygen Consumption / Q000187:drug effects*; D019265:Spectroscopy, Near-Infrared
D009638:Norepinephrine