Tin mesoporphyrin in conjunction with retinoic acid reverses the retinoic acid induced enhancement of phospholipase A(2) activity in vivo in rats.
Retinol (Vitamin A) is known to destabilize membranes. The effect of one of its natural derivatives, Retinoic Acid, was therefore studied on membrane stability, by inversely correlating this stability with Phospholipase A(2) activity. Lipid metalloporphyrin interactions have been the object of intense research in recent times. Our results revealed that the administration of Retinoic Acid (50,000 I.U.) caused a tremendous induction of hepatic Phospholipase A(2) activity in Wistar rats. However when Retinoic Acid and Tin-mesoporphyrin (50 micromol/kgbw) were co-administered, hepatic Phospholipase A(2) activity was inhibited. This result clearly reveals a possible therapeutic application of this metalloporphyrin in alleviating membrane destabilization, connected with Retinoic acid administration.
Tiwari
Manisha
M
Dr. B.R. Ambedkar Center for Biomedical Research, University of Delhi, Delhi, India.
Chandra
Ramesh
R
Das
Sujata K
SK
Prakash
Satya
S
D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D002463:Cell Membrane Permeability / Q000187:drug effects*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D008099:Liver / Q000201:enzymology*; D008565:Membrane Proteins / Q000032:analysis / Q000378:metabolism*; D008665:Metalloporphyrins / Q000494:pharmacology*; D015394:Molecular Structure; D010741:Phospholipases A / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D014212:Tretinoin / Q000494:pharmacology*
D004791:Enzyme Inhibitors; D008565:Membrane Proteins; D008665:Metalloporphyrins; C055421:tin mesoporphyrin; D014212:Tretinoin; D010741:Phospholipases A