Coronary artery calcification progression is heritable.
BACKGROUND
Coronary artery calcification (CAC), a marker of coronary artery atherosclerosis, can be measured accurately and noninvasively with the use of electron beam computed tomography. Serial measures of CAC quantify progression of calcified coronary artery plaque. Little is known about the role of genetic factors in progression of CAC quantity.


RESULTS
We quantified the relative contributions of measured risk factors and unmeasured genes to CAC progression measured by 2 electron beam computed tomography examinations an average of 7.3 years apart in 877 asymptomatic white adults (46% men) from 625 families in a community-based sample. After adjustment for baseline risk factors and CAC quantity, the estimated heritability of CAC progression was 0.40 (P<0.001). Baseline risk factors and CAC quantity explained 64% of the variation in CAC progression. Thus, genetic factors explained 14% of the variation [(100-64) x (0.40)] in CAC progression. After adjustment for risk factors, the estimated genetic correlation (pleiotropy) between baseline CAC quantity and CAC progression was 0.80 and was significantly different than 0 (P<0.001) and 1 (P=0.037). The environmental correlation between baseline CAC quantity and CAC progression was 0.42 and was significantly different than 0 (P=0.006).


CONCLUSIONS
Evidence was found that many but not all genetic factors influencing baseline CAC quantity also influence CAC progression. The identification of common and unique genetic influences on these traits will provide important insights into the genetic architecture of coronary artery atherosclerosis.
Cassidy-Bushrow
Andrea E
AE
Department of Epidemiology, University of Michigan, 611 Church St, Ann Arbor, MI 48104-3028, USA.
Bielak
Lawrence F
LF
Sheedy
Patrick F
PF
Turner
Stephen T
ST
Kullo
Iftikhar J
IJ
Lin
Xihong
X
Peyser
Patricia A
PA
D000328:Adult; D000368:Aged; D000886:Anthropometry; D002114:Calcinosis / Q000453:epidemiology / Q000235:genetics*; D002118:Calcium / Q000032:analysis; D015331:Cohort Studies; D015897:Comorbidity; D003324:Coronary Artery Disease / Q000453:epidemiology / Q000235:genetics*; D003920:Diabetes Mellitus / Q000453:epidemiology; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006949:Hyperlipidemias / Q000453:epidemiology; D006973:Hypertension / Q000453:epidemiology; D016013:Likelihood Functions; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D019655:Quantitative Trait, Heritable; D012307:Risk Factors; D012907:Smoking / Q000453:epidemiology; D014057:Tomography, X-Ray Computed
D002118:Calcium