title: Reduction of hexachlorocyclohexane-induced oxidative stress and cytotoxicity in rat liver by Emblica officinalis gaertn.
abstract: The effect of prefeeding of dehydrated E. officinalis (amla) powder at 5 and 10% levels on hexachlorocyclohexane (HCH)-induced changes in multicomponent antioxidant system and lipid peroxides in rat liver was studied. HCH induced significant elevation in hepatic malondialdehyde, conjugated dienes and hydroperoxides. The prefeeding of amla at 10% level could decrease the formation of these lipid peroxides significantly. The HCH abuse resulted in a significant reduction in hepatic glutathione S-transferase (GST), glucose-6-phosphate dehydrogenase (G-6-PDH) and superoxide dismutase (SOD) activities with an elevation in the activities of glutathione peroxidase and gamma-glutamyl transpeptidase (GGT). On the other hand, the HCH-induced impairment in hepatic catalase, G-6-PDH and SOD activities were modulated by amla at the 10% level of intake. Prefeeding of amla at 5 and 10% levels appeared to reduce the HCH-induced raise in renal GGT activity. The results show the elevation of hepatic antioxidant system and reduction of cytotoxic products as a result of prefeeding of amla, which were otherwise affected by the HCH administration.
authors.affiliation: Biochemistry and Nutrition Discipline, Defence Food Research Laboratory, Mysore 570011, India.
authors.forename: K R
authors.initials: KR
authors.lastname: Anilakumar
authors.forename: N S
authors.initials: NS
authors.lastname: Nagaraj
authors.forename: K
authors.initials: K
authors.lastname: Santhanam
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000032:analysis; D056486:Chemical and Drug Induced Liver Injury; D019610:Cytoprotection / Q000187:drug effects*; D004435:Eating / Q000187:drug effects; D001556:Hexachlorocyclohexane; D007668:Kidney / Q000201:enzymology; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000737:chemistry / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology; D008107:Liver Diseases / Q000473:pathology / Q000517:prevention & control*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects*; D029842:Phyllanthus emblica / Q000737:chemistry; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D015430:Weight Gain / Q000187:drug effects; D005723:gamma-Glutamyltransferase / Q000032:analysis
chemical_list: D000975:Antioxidants; D010936:Plant Extracts; D001556:Hexachlorocyclohexane; D005723:gamma-Glutamyltransferase