title: Synthesis, characterization and hydrolytic degradation study of polyetheresteramide copolymers based on epsilon-caprolactone, 6-aminocaproic acid, and poly(ethylene glycol).
abstract: In this paper, a new kind of biodegradable aliphatic polyetheresteramide copolymers (PEEA) based on epsilon-caprolactone, 6-aminocaproic acid, and poly(ethylene glycol) (PEG) were synthesized by melt polymerization method. The obtained copolymers were characterized by 1H-NMR. The thermal properties of PEEA copolymers were studied by DSC and TGA/DTA under nitrogen atmosphere. The water absorption and hydrolytic degradation behavior was also studied in detail. With the increase in PEG content or the decrease in caprolactone content, the water absorption of the copolymers increased accordingly. For the hydrolytic degradation behavior, with the increase in PEG content or caprolactone content, the degradation rate increased then.
authors.affiliation: State Key Laborotary of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: CaiBing
authors.initials: C
authors.lastname: Liu
authors.forename: ZhiYong
authors.initials: Z
authors.lastname: Qian
authors.forename: WenJuan
authors.initials: W
authors.lastname: Jia
authors.forename: MeiJuan
authors.initials: M
authors.lastname: Huang
authors.forename: GuoTao
authors.initials: G
authors.lastname: Chao
authors.forename: ChangYang
authors.initials: C
authors.lastname: Gong
authors.forename: HongXin
authors.initials: H
authors.lastname: Deng
authors.forename: YanJun
authors.initials: Y
authors.lastname: Wen
authors.forename: JinLiang
authors.initials: J
authors.lastname: Yang
authors.forename: MaLing
authors.initials: M
authors.lastname: Gou
authors.forename: MingJing
authors.initials: M
authors.lastname: Tu
mesh_terms: D000042:Absorption; D015119:Aminocaproic Acid / Q000737:chemistry*; D002208:Caproates / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D007783:Lactones / Q000737:chemistry*; D008422:Materials Testing; D008954:Models, Biological; D011092:Polyethylene Glycols / Q000737:chemistry*; D011108:Polymers / Q000138:chemical synthesis* / Q000378:metabolism*; D014867:Water / Q000378:metabolism
chemical_list: D002208:Caproates; D007783:Lactones; D011108:Polymers; D014867:Water; D011092:Polyethylene Glycols; C121056:caprolactone; D015119:Aminocaproic Acid