Chemoprophylaxis of colorectal cancer in inflammatory bowel disease: current concepts.
Ulcerative colitis and Crohn's disease both confer an increased risk of developing colorectal cancer. The use of 5-aminosalicylate as a remission-inducing agent has been long accepted. Its use as a potential chemoprophylactic agent has been proposed and is used by some practitioners. This review examines the most recent data on 5-aminosalicylate as a chemoprophylactic drug as well as ursodeoxycholic acid, folic acid, azathioprine, and 6-mercaptopurine.
Levine
Jonathan S
JS
Center for Crohn's and Colitis, Division of Gastroenterology, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA. levinejona@gmail.com
Burakoff
Robert
R
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D001379:Azathioprine / Q000627:therapeutic use*; D002756:Cholagogues and Choleretics / Q000627:therapeutic use; D015179:Colorectal Neoplasms / Q000209:etiology / Q000517:prevention & control*; D005492:Folic Acid / Q000627:therapeutic use*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D015212:Inflammatory Bowel Diseases / Q000150:complications* / Q000188:drug therapy; D015122:Mercaptopurine / Q000627:therapeutic use*; D019804:Mesalamine / Q000627:therapeutic use*; D016896:Treatment Outcome; D014580:Ursodeoxycholic Acid / Q000627:therapeutic use*; D014803:Vitamin B Complex / Q000627:therapeutic use
D000894:Anti-Inflammatory Agents, Non-Steroidal; D002756:Cholagogues and Choleretics; D007166:Immunosuppressive Agents; D014803:Vitamin B Complex; D019804:Mesalamine; D014580:Ursodeoxycholic Acid; D005492:Folic Acid; D015122:Mercaptopurine; D001379:Azathioprine