Sodium transporters in kidney role in health and disease.
Sodium is an important cation and has an important role in BP regulation and ECF balance. Kidney plays an important role in sodium balance. Almost 99% of filtered sodium is reabsorbed. The absorption occurs via sodium transporters located in the various segments of the nephron. Each of these transporters has unique features and is blocked by a specific diuretic. The activating and inactivating mutations of these transporters are associated with important clinical syndromes. The understanding of these transporters and their mutations is essential for proper diagnosis and management of syndromes associated with the defects of these transporters. Also the knowledge of sodium transporters helps in understanding the role of kidney in pathogenesis of hypertension and pharmacodynamics of diuretic action.
Sahay
Manisha
M
Department of Nephrology, Osmania Medical College/Osmania General Hospital, Hyderabad.
Narayen
G
G
Anuradha
D004232:Diuretics / Q000494:pharmacology; D006304:Health Status; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000378:metabolism; D007668:Kidney / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology; D007674:Kidney Diseases / Q000378:metabolism* / Q000652:urine; D012964:Sodium / Q000378:metabolism* / Q000502:physiology; D027981:Symporters / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism*; D014882:Water-Electrolyte Balance / Q000187:drug effects / Q000502:physiology
D004232:Diuretics; D027981:Symporters; D012964:Sodium