title: Hepatocellular carcinoma with direct invasion to the stomach.
abstract: A 71-year-old man was admitted to our hospital with abdominal pain. Hepatocellular carcinoma (HCC) had been diagnosed 2 years earlier and he had undergone 7 courses of intra-hepato-arterial chemotherapy (IHAC). We performed gastrointestinal fiberscopy and identified a massive protrusion on the lesser curvature. Abdominal contrast-enhanced computed tomography revealed multiple hepatic masses and an extrahepatic enlarged mass with invasion to the pancreas and stomach. A specimen for endoscopic biopsy revealed adenocarcinoma that stained positive for alpha-fetoprotein. Gastrointestinal bleeding resulting from direct invasion of HCC is unusual.
authors.affiliation: Division of Gastroenterology and Department of Integrated Medicine I, Omiya Medical Center, Jichi Medical School, Saitama. hiromuinoue-gi@umin.ac.jp
authors.forename: Hiromu
authors.initials: H
authors.lastname: Inoue
authors.forename: Yukihisa
authors.initials: Y
authors.lastname: Sawada
authors.forename: Kaori
authors.initials: K
authors.lastname: Ochiai
authors.forename: Hideaki
authors.initials: H
authors.lastname: Honda
authors.forename: Junko
authors.initials: J
authors.lastname: Murayama
authors.forename: Yasutaka
authors.initials: Y
authors.lastname: Kudo
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Nakashima
authors.forename: Noriyoshi
authors.initials: N
authors.lastname: Sagihara
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Miyatani
authors.forename: Ikuo
authors.initials: I
authors.lastname: Nakamura
authors.forename: Yukio
authors.initials: Y
authors.lastname: Yoshida
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D006528:Carcinoma, Hepatocellular / Q000473:pathology* / Q000628:therapy; D006801:Humans; D007261:Infusions, Intra-Arterial; D008113:Liver Neoplasms / Q000473:pathology* / Q000628:therapy; D008297:Male; D009361:Neoplasm Invasiveness; D011859:Radiography; D013274:Stomach Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000628:therapy; D016896:Treatment Outcome