[Changes of serum nitric oxide level after acute hepatic injury in mice and the effect of yugan capsule on it].
OBJECTIVE
To observe the changes of serum nitric oxide (NO) level after acute hepatic injury (AHI) in mice and the effect of Yugan capsule (YC) on it.


METHODS
The mouse AHI model was induced by carbon tetrachloride ( CC14 ) at different time points. After treatment with or without YC, serum nitric oxide ( NO) , anlanine aminotransferase (ALT) and aspartate aminotransferase (AST) were detected, and liver histopathologic injury was observed at different time points after AHI, respectively.


RESULTS
Serum NO, ALT and AST in the model group escalated significantly with time going, while they decreased and liver histopathologic injury was improved in the YC groups.


CONCLUSIONS
The serum levels of NO, ALT and AST increased,and liver histopathologic injury gradually aggravated with time going after CCl4 injection. Yugan capsule could decrease the levels of ALT, AST and NO.
Cheng
Xin
X
The Second Hospital Affiliated to Xiangya Medical College, Zhongnan University, Changsha. xinc08@yahoo.com.cn
Xie
Chao-liang
CL
Wang
Jing
J
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D001219:Aspartate Aminotransferases / Q000097:blood; D056486:Chemical and Drug Induced Liver Injury / Q000097:blood* / Q000188:drug therapy / Q000201:enzymology; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D051379:Mice; D009569:Nitric Oxide / Q000097:blood*; D013607:Tablets
D000975:Antioxidants; D004365:Drugs, Chinese Herbal; D013607:Tablets; C550194:yugan; D009569:Nitric Oxide; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase