[Contact dermatitis caused by acetazolamide under occlusion].
BACKGROUND
Acetazolamide is a carbonic anhydrase inhibitor used topically for local secondary treatment of posttraumatic or postoperative edema.


METHODS
Two women had contact dermatitis, secondarily extensive, after local cutaneous use of acetazolamide under a compression panty after liposuction. The eruption disappeared after acetazolamide was stopped and local treatment administered. Cutaneous tests were positive for acetazolamide.


CONCLUSIONS
Local allergic reactions are mentioned in the monograph on topical acetazolamide. Cases of contact dermatitis from this drug have not so far been published, but French adverse drug reaction reporting data include 10 other cases of eczema or rash at the application site. In one of these, a positive reaction was observed on readministration, and in 2 cases allergy skin tests were positive. The application of the drug under occlusion, which is contraindicated, may have contributed to spreading the lesions. Cases have also been described with another carbonic anhydrase inhibitor, dorzolamide, used in ophthalmology.
Daveluy
Amélie
A
Centre de pharmacovigilance, Département de pharmacologie, Inserm U657, Université Victor Segalen, CHU, Bordeaux. amelie.daveluy@u-bordeaux2.fr
Vial
Thierry
T
Marty
Laurine
L
Miremont-Salamé
Ghada
G
Moore
Nicholas
N
Haramburu
Françoise
F
D000086:Acetazolamide / Q000008:administration & dosage / Q000009:adverse effects*; D000279:Administration, Cutaneous; D000328:Adult; D016907:Adverse Drug Reaction Reporting Systems; D002257:Carbonic Anhydrase Inhibitors / Q000008:administration & dosage / Q000009:adverse effects*; D017449:Dermatitis, Allergic Contact / Q000209:etiology*; D004342:Drug Hypersensitivity / Q000175:diagnosis; D005260:Female; D005602:France; D006801:Humans; D015187:Lipectomy; D012882:Skin Tests
D002257:Carbonic Anhydrase Inhibitors; D000086:Acetazolamide