Solid lipid nanoparticles for targeted brain drug delivery.
The present review discusses the potential use of solid lipid nanoparticles for brain drug targeting purposes. The state of the art on surfactant-coated poly(alkylcyanoacrylate) nanoparticles specifically designed for brain targeting is given by emphasizing the transfer of this technology to solid lipid matrices. The available literature on solid lipid nanoparticles and related carriers for brain drug targeting is revised as well. The potential advantages of the use of solid lipid nanoparticles over polymeric nanoparticles are accounted on the bases of a lower cytotoxicity, higher drug loading capacity, and best production scalability. Solid lipid nanoparticles physicochemical characteristics are also particularly regarded in order to address the critical issues related to the development of suitable brain targeting formulations. A critical consideration on the potential application of such technology as related to the current status of brain drug development is also given.
Blasi
Paolo
P
Department of Chemistry and Technology of Drugs, School of Pharmacy, University of Perugia, Via del Liceo 1, 06123 Perugia, Italy. kaolino@unipg.it
Giovagnoli
Stefano
S
Schoubben
Aurélie
A
Ricci
Maurizio
M
Rossi
Carlo
C
D000818:Animals; D001812:Blood-Brain Barrier / Q000378:metabolism; D001921:Brain / Q000378:metabolism*; D002491:Central Nervous System Agents / Q000008:administration & dosage; D016503:Drug Delivery Systems; D006801:Humans; D008055:Lipids / Q000008:administration & dosage; D053758:Nanoparticles; D013501:Surface-Active Agents / Q000008:administration & dosage
D002491:Central Nervous System Agents; D008055:Lipids; D013501:Surface-Active Agents