The polyacetylene falcarindiol with COX-1 activity isolated from Aegopodium podagraria L.
Extracts of Aegopodium podagraria L. were screened in vitro for cyclooxygenase-1 (COX-1) inhibitory activity. The isolation of the active compound falcarindiol was achieved by bioassay-guided fractionation. The identification of the active compound was confirmed by (1)H NMR and (13)C NMR. The IC(50)-value of falcarindiol was 0.3 microM in the COX-1 assay. A quantitative determination of the seasonal variation in the content of falcarindiol in different plant parts was carried out by HPLC analysis. The flowers from Aegopodium podagraria collected in June 2006 had the highest concentration of falcarindiol (88 mg/g plant material).
Prior
Rikke M
RM
Department of Medicinal Chemistry, The Danish University of Pharmaceutical Sciences, 2 Universitetsparken, 2100 Copenhagen O, Denmark.
Lundgaard
Nanna H
NH
Light
Marnie E
ME
Stafford
Gary I
GI
van Staden
Johannes
J
Jäger
Anna K
AK
D019661:Apiaceae / Q000737:chemistry*; D001681:Biological Assay; D002851:Chromatography, High Pressure Liquid; D051545:Cyclooxygenase 1 / Q000187:drug effects* / Q000378:metabolism; D016861:Cyclooxygenase Inhibitors / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D003718:Denmark; D053280:Diynes / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D005233:Fatty Alcohols / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D008519:Medicine, Traditional; D010936:Plant Extracts / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D018514:Plant Structures; D012621:Seasons
D016861:Cyclooxygenase Inhibitors; D053280:Diynes; D005233:Fatty Alcohols; D010936:Plant Extracts; C034379:falcarindiol; D051545:Cyclooxygenase 1