title: Potent and selective CC-chemokine receptor-2 (CCR2) antagonists as a potential treatment for asthma.
abstract: A number of compounds bearing a quaternary ammonium moiety were found to be antagonists with nanomolar binding affinity for the chemokine receptor-2. The structure-activity relationships in the series are described herein along with some detailed characterization of the interesting compounds.
authors.affiliation: Johnson & Johnson Pharmaceutical Research and Development, Cranbury, NJ 08512, USA. bharat.lagu@novartis.com
authors.forename: Bharat
authors.initials: B
authors.lastname: Lagu
authors.forename: Chrissy
authors.initials: C
authors.lastname: Gerchak
authors.forename: Meng
authors.initials: M
authors.lastname: Pan
authors.forename: Cuifen
authors.initials: C
authors.lastname: Hou
authors.forename: Monica
authors.initials: M
authors.lastname: Singer
authors.forename: Ravi
authors.initials: R
authors.lastname: Malaviya
authors.forename: Michele
authors.initials: M
authors.lastname: Matheis
authors.forename: Gil
authors.initials: G
authors.lastname: Olini
authors.forename: Druie
authors.initials: D
authors.lastname: Cavender
authors.forename: Michael
authors.initials: M
authors.lastname: Wachter
mesh_terms: D018927:Anti-Asthmatic Agents / Q000627:therapeutic use*; D001249:Asthma / Q000188:drug therapy*; D006801:Humans; D054390:Receptors, CCR2; D019707:Receptors, Chemokine / Q000037:antagonists & inhibitors*
chemical_list: D018927:Anti-Asthmatic Agents; C515334:CCR2 protein, human; D054390:Receptors, CCR2; D019707:Receptors, Chemokine