Colistin methanesulfonate against multidrug-resistant Acinetobacter baumannii in an in vitro pharmacodynamic model.
Using an in vitro pharmacodynamic model, a multidrug-resistant strain of Acinetobacter baumannii was exposed to colistin methanesulfonate alone and in combination with ceftazidime. Pre- and postexposure colistin sulfate MICs were determined. A single daily dose of colistin methanesulfonate combined with continuous-infusion ceftazidime prevented regrowth and postexposure MIC increases.
Kroeger
Lisa A
LA
Department of Experimental and Clinical Pharmacology, University of Minnesota College of Pharmacy, 9-157 Weaver-Densford Hall, 308 Harvard Street SE, Minneapolis, MN 55455, USA.
Hovde
Laurie B
LB
Mitropoulos
Isaac F
IF
Schafer
Jeremy
J
Rotschafer
John C
JC
D040981:Acinetobacter baumannii / Q000187:drug effects*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002442:Ceftazidime / Q000494:pharmacology; D003091:Colistin / Q000031:analogs & derivatives* / Q000494:pharmacology; D015169:Colony Count, Microbial; D004338:Drug Combinations; D024901:Drug Resistance, Multiple, Bacterial; D008826:Microbial Sensitivity Tests
D000900:Anti-Bacterial Agents; D004338:Drug Combinations; D002442:Ceftazidime; C004691:colistinmethanesulfonic acid; D003091:Colistin