title: Intrauterine gangrene of the lower extremity in the newborn: a report of two cases.
abstract: We describe 2 cases of intrauterine gangrene involving the lower extremity in 2 unrelated neonates. Both cases were complicated by prematurity, and 1 case was complicated by an intrauterine distal femur fracture and twin-twin transfusion syndrome. Both cases resulted in profound ischemic necrosis from the knee to the foot, requiring knee disarticulation. In both cases, a follow-up period of 7 years is now completed, and no further medical or surgical complications have arisen.
authors.affiliation: Department of Orthopaedic Surgery, Alfred I. duPont Hospital for Children, Wilmington, DE 19803, USA.
authors.forename: Mary K
authors.initials: MK
authors.lastname: Nagai
authors.forename: Aaron G
authors.initials: AG
authors.lastname: Littleton
authors.forename: Peter G
authors.initials: PG
authors.lastname: Gabos
mesh_terms: D000328:Adult; D004188:Disarticulation; D005260:Female; D005315:Fetal Diseases / Q000473:pathology; D005330:Fetofetal Transfusion / Q000150:complications; D050723:Fractures, Bone / Q000150:complications / Q000000981:diagnostic imaging; D005734:Gangrene / Q000151:congenital / Q000473:pathology / Q000601:surgery; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007511:Ischemia / Q000151:congenital*; D035002:Lower Extremity / Q000098:blood supply / Q000473:pathology*; D008297:Male; D009336:Necrosis; D011247:Pregnancy; D011272:Pregnancy, Multiple; D011859:Radiography; D012307:Risk Factors; D013927:Thrombosis / Q000150:complications