title: Cerebrosides and tocopherol trimers from the seeds of Euryale ferox.
abstract: Two new cerebrosides, ferocerebrosides A (1) [(2S,3R,4E,8E,2'R)-1-O-(beta-glucopyranosyl)-N-(2'-hydroxydocosanoyl)-4,8-sphingadienine] and B (2) [(2S,3R,4E,8E,2'R)-1-O-(beta-glucopyranosyl)-N-(2'-hydroxytetracosanoyl)-4,8-sphingadienine], two new tocopherol trimers, ferotocotrimers C (5) and D (6), and two known tocopherol trimers, IVb (3) and IVa (4), were isolated from the seeds of Euryale ferox. Their structures were determined on the basis of spectroscopic data, especially 1D and 2D NMR experiments. Compounds 1 and 2 showed cytotoxicity in the brine shrimp lethality bioassay, with LC50 values of 0.17 and 0.20 mM, respectively.
authors.affiliation: Fiber Research Division, Industrial Technology Research Institute, Hsinchu, Taiwan, 310, Republic of China.
authors.forename: Lie-Ching
authors.initials: LC
authors.lastname: Row
authors.forename: Jiau-Ching
authors.initials: JC
authors.lastname: Ho
authors.forename: Chiu-Ming
authors.initials: CM
authors.lastname: Chen
mesh_terms: D000818:Animals; D001156:Artemia / Q000187:drug effects*; D002554:Cerebrosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D030702:Nymphaeaceae / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry*; D012639:Seeds / Q000737:chemistry; D024505:Tocopherols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D002554:Cerebrosides; D004365:Drugs, Chinese Herbal; D024505:Tocopherols