title: Successful treatment of a child with a primary intracranial rhabdomyosarcoma with chemotherapy and radiation therapy.
abstract: Primary rhabdomyosarcoma of the central nervous system (CNS) is rare in both adults and children (Taratuto et al. (1985) Acta Neuropathol (Berl) 66(2):98-104). The outcome in the majority of cases is poor, and many cases are associated with early mortality (Celli et al. (1998) J Neurooncol 36(3):259-267). There are very few cases reported in the literature of survival beyond 2 years after diagnosis. We report a case of primary intracranial embryonal rhabdomyosarcoma in a 5-year-old girl who was treated successfully with local radiation therapy (RT) and a combination of two different chemotherapeutic regimens. The patient is clinically well 26 months after diagnosis, with no definitive evidence of residual disease.
authors.affiliation: Division of Pediatric Hematology/Oncology/BMT, British Columbia's Children's Hospital, Room A119, 4480 Oak Street, Vancouver, BC, Canada, V6H 3V4.
authors.forename: Gregory Michael Taylor
authors.initials: GM
authors.lastname: Guilcher
authors.forename: Glenda
authors.initials: G
authors.lastname: Hendson
authors.forename: Karen
authors.initials: K
authors.lastname: Goddard
authors.forename: Paul
authors.initials: P
authors.lastname: Steinbok
authors.forename: Mason
authors.initials: M
authors.lastname: Bond
mesh_terms: D001932:Brain Neoplasms / Q000175:diagnosis / Q000628:therapy*; D002675:Child, Preschool; D004358:Drug Therapy / Q000379:methods*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D011878:Radiotherapy / Q000379:methods*; D012208:Rhabdomyosarcoma / Q000175:diagnosis / Q000628:therapy*; D014057:Tomography, X-Ray Computed / Q000379:methods