title: The role of radiofrequency ablation in multiple liver metastases to debulk the tumor: a pilot study before alternative therapies.
abstract: BACKGROUND
  In this study, our aim was to proceed with the first study of our patients by evaluating different metastatic tumor to the liver to check whether, after debulking the tumor with radiofrequency ablation (RFA), the chemotherapy, could increase the survival in these patients as a pilot study before applying alternative therapies in the future.
  
  
  METHODS
  We studied 11 patients, 7 male, 4 female; age mean, 68 years (50-84). The tumors considered were carcinoid (3), gastrinoma (3), a new endocrine of unknown origin (2), colorectal (2), and breast (1).
  
  
  RESULTS
  All of the patients underwent laparoscopic RFA with a prior confirmatory biopsy and were discharged after 23 hours. No pain, bleeding, or wound infections were reported. One (1) patient with a gastrinoma died 9 months following surgery from a myocardial infarction. All other patients are still alive, although 2 experienced hepatic recurrences.
  
  
  CONCLUSIONS
  The 11 patients in this series showed that RFA combined with chemotherapy is a viable therapeutic choice for patients with cancer that has metastasized to the liver. New therapies are still needed.
authors.affiliation: Division of General Surgery, Department of Surgery, Texas Tech University Health Sciences Center, Lubbock, Texas 79415, USA. eldo.frezza@ttuhsc.edu
authors.forename: Eldo E
authors.initials: EE
authors.lastname: Frezza
authors.forename: Mitchell S
authors.initials: MS
authors.lastname: Wachtel
authors.forename: Barnard
authors.initials: B
authors.lastname: Barragan
authors.forename: Maurizio
authors.initials: M
authors.lastname: Chiriva-Internati
authors.forename: Everardo
authors.initials: E
authors.lastname: Cobos
mesh_terms: D000230:Adenocarcinoma / Q000556:secondary; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000473:pathology; D002276:Carcinoid Tumor / Q000556:secondary; D018278:Carcinoma, Neuroendocrine / Q000556:secondary; D017115:Catheter Ablation; D002423:Cause of Death; D017024:Chemotherapy, Adjuvant; D003110:Colonic Neoplasms / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D015408:Gastrinoma / Q000556:secondary; D006801:Humans; D010535:Laparoscopy; D008113:Liver Neoplasms / Q000188:drug therapy / Q000556:secondary* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000209:etiology; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D009382:Neoplasms, Unknown Primary / Q000473:pathology; D010865:Pilot Projects; D012004:Rectal Neoplasms / Q000473:pathology; D012189:Retrospective Studies; D015996:Survival Rate