title: Effects of accumulated S-adenosylmethionine on growth of yeast cells.
abstract: S-adenosylmethionine (SAM) accumulated in cultured yeast cells and affected growth in two ways. High levels of intracellular SAM in yeast inhibited early growth, but increased growth in medium without sources of nitrogen and sulfur. Accumulated SAM in the yeast cells was recycled as a nutritional source depending on the sulfur and nitrogen contents of the medium.
authors.affiliation: National Research Institute of Brewing, Japan.
authors.forename: Megumi
authors.initials: M
authors.lastname: Shobayashi
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Fujii
authors.forename: Haruyuki
authors.initials: H
authors.lastname: Iefuji
mesh_terms: D003470:Culture Media / Q000494:pharmacology; D009584:Nitrogen / Q000378:metabolism; D012436:S-Adenosylmethionine / Q000378:metabolism* / Q000494:pharmacology; D012441:Saccharomyces cerevisiae / Q000166:cytology / Q000254:growth & development*; D013455:Sulfur / Q000378:metabolism
chemical_list: D003470:Culture Media; D013455:Sulfur; D012436:S-Adenosylmethionine; D009584:Nitrogen