Interferon-gamma is produced by another player of innate immune responses: the interferon-producing killer dendritic cell (IKDC).
Interferon-gamma is a key cytokine in tumor immunosurveillance. The recently described interferon-producing killer dendritic cell (IKDC), can be distinguished from other innate effectors by its ability to kill a large variety of tumor cells and to produce high amounts of interferon-gamma after encountering tumors in the absence of exogenous cytokines. The cytotoxic activity of IKDC was unraveled during an efficient immunotherapy combining c-kit tyrosine kinase inhibitors and interleukin-2, and is mediated through tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and interferon type IIR.
Bonmort
Mathieu
M
Institut National de la Santé et de la Recherche Médicale, U805, Villejuif, France.
Ullrich
Evelyn
E
Mignot
Grégoire
G
Jacobs
Bénédikt
B
Chaput
Nathalie
N
Zitvogel
Laurence
L
D000818:Animals; D000954:Antigens, Surface / Q000378:metabolism; D001549:Benzamides; D003713:Dendritic Cells / Q000166:cytology / Q000378:metabolism*; D006801:Humans; D000068877:Imatinib Mesylate; D007371:Interferon-gamma / Q000096:biosynthesis* / Q000378:metabolism / Q000502:physiology*; D007376:Interleukin-2 / Q000378:metabolism; D007694:Killer Cells, Natural / Q000378:metabolism*; D037181:Lectins, C-Type / Q000378:metabolism; D017493:Leukocyte Common Antigens / Q000378:metabolism; D008954:Models, Biological; D055651:NK Cell Lectin-Like Receptor Subfamily B; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000378:metabolism; D010879:Piperazines / Q000494:pharmacology; D019009:Proto-Oncogene Proteins c-kit / Q000378:metabolism; D011743:Pyrimidines / Q000494:pharmacology; D053221:TNF-Related Apoptosis-Inducing Ligand / Q000378:metabolism
D000954:Antigens, Surface; D001549:Benzamides; D007376:Interleukin-2; C527203:KLRB1 protein, human; D037181:Lectins, C-Type; D055651:NK Cell Lectin-Like Receptor Subfamily B; D010879:Piperazines; D011743:Pyrimidines; D053221:TNF-Related Apoptosis-Inducing Ligand; D007371:Interferon-gamma; D000068877:Imatinib Mesylate; D019009:Proto-Oncogene Proteins c-kit; D017493:Leukocyte Common Antigens