title: Introduction of quantitative methods in pharmacology and clinical pharmacology: a historical overview.
authors.forename: A J
authors.initials: AJ
authors.lastname: Atkinson
authors.forename: R L
authors.initials: RL
authors.lastname: Lalonde
mesh_terms: D000818:Animals; D002986:Clinical Trials as Topic / Q000266:history* / Q000379:methods; D003198:Computer Simulation; D018450:Disease Progression; D004305:Dose-Response Relationship, Drug; D049673:History, 20th Century; D006801:Humans; D008954:Models, Biological; D015233:Models, Statistical; D017711:Nonlinear Dynamics; D010599:Pharmacokinetics; D010600:Pharmacology / Q000266:history* / Q000379:methods; D010601:Pharmacology, Clinical / Q000266:history* / Q000379:methods; D012107:Research Design