Nocistatin attenuated the nociceptin induced c-Fos expression in the mouse hippocampus.
Nocistatin and nociceptin/orphaninFQ (N/OFQ) are the two new peptides which may have roles in nociception, memory, anxiety, and other biological functions. Nocistatin acts as a functional antagonist to N/OFQ in several functions, but their neuro-anatomical sites of interaction are unknown. We investigated the effect of combined intracerebroventricular (i.c.v.) injection of nocistatin with N/OFQ, on N/OFQ induced c-Fos expression in the mouse hippocampus, using c-Fos immunohistochemistry. We found that co-injection of nocistatin with N/OFQ significantly attenuated N/OFQ induced c-Fos expression in the hippocampus.
Kazi
J A
JA
Department of Anaesthesia, Yong Loo Lin School of Medicine, National University of Singapore, 5 Lower Kent Ridge Road, Singapore 119074, Singapore. annajk@nus.edu.sg
Liu
E H C
EH
Lee
T L
TL
Tachibana
S
S
D000701:Analgesics, Opioid / Q000494:pharmacology*; D000818:Animals; D006624:Hippocampus / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D007276:Injections, Intraventricular; D051379:Mice; D018847:Opioid Peptides / Q000494:pharmacology*; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism*; D000097629:Nociceptin
D000701:Analgesics, Opioid; D018847:Opioid Peptides; D016760:Proto-Oncogene Proteins c-fos; D000097629:Nociceptin; C111148:nocistatin