[Aike mixture has good anti-inflammatory and analgesic effects on mice].
OBJECTIVE
To study the anti-inflammatory and analgesic actions of Aike Mixture (AKM).


METHODS
A total of 100 male mice were randomly assigned into 5 groups: a normal control group, a drug control group (a hydrocortisone subgroup and an atropine subgroup), a high-dose AKM group, a mid-dose AKM group and a low-dose AKM group. Xylene was spread on the left ear of the experimental mice to induce inflammation, and 1% acetic acid solution injected into the abdominal cavity to produce pain so as to cause the body bend. Different doses of AKM were given and their actions observed.


RESULTS
AKM had obvious anti-inflammatory effect on the xylene-induced ear tumefaction and inhibited the pain-caused body bend in the AKM groups, with significant difference from the normal control (P < 0.01).


CONCLUSIONS
AKM has good anti-inflammatory and analgesic effects, which is of clinical significance in the treatment of chronic prostatitis.
Zhang
Min-jian
MJ
Department of Andrology, People's Hospital Affiliated to Fujian College of Traditional Chinese Medicine, Fuzhou, Fujian 350004, China. zmj83@tom.com
Chu
Ke-dan
KD
Cheng
Xin-ling
XL
Pan
Xu-dong
XD
Cheng
Wan-jun
WJ
Yu
Kai-yuan
KY
Tan
Yu-hong
YH
Liu
Jin-zhi
JZ
Shi
Ya-lei
YL
Zheng
Sheng
S
Liu
Qiao-bin
QB
D000818:Animals; D002908:Chronic Disease; D004195:Disease Models, Animal; D004338:Drug Combinations; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D008517:Phytotherapy; D011472:Prostatitis / Q000188:drug therapy*; D012503:Saponins / Q000494:pharmacology* / Q000627:therapeutic use
D004338:Drug Combinations; D012503:Saponins; D009828:Oleanolic Acid; C025759:saikosaponin D