title: [Anaesthesia, a cause of fetal distress?].
abstract: OBJECTIVE
  To describe the effects of anaesthetic techniques and agents on the risk of fetal distress during labour pain relief and anaesthesia for caesarean section.
  
  
  METHODS
  Data on obstetric anaesthesia- and analgesia-induced fetal distress were searched in Medline database using MESH terms: fetal distress, anaesthesia, analgesia, labour, caesarean section, and umbilical artery pH. Trials published in English or French language were selected.
  
  
  RESULTS
  Because of their haemodynamic effects, regional anaesthesia and analgesia, especially spinal anaesthesia for Caesarean section, could induce a decrease in umbilical artery pH (UApH). Moreover, intravenous ephedrine, especially when used in large doses can worsen the acidosis. Labour epidural analgesia is associated with a better acid-base balance than systemic analgesia. Experimental studies have demonstrated harmful effects of systemic opioids and hypnotic drugs on UApH and the foetal brain respectively. Clinical implications of these potentially detrimental effects remain to be determined.
  
  
  CONCLUSIONS
  All obstetric anaesthesia and analgesia techniques are associated with a theoretical risk of fetal distress, but given the fact that regional anaesthesia techniques are also associated with well-demonstrated benefits for the mother and the newborn, the latter remain the preferred choice in obstetric practice.
authors.affiliation: Département d'anesthésie-réanimation, hôpital Antoine-Béclère, APHP, Clamart cedex, France.
authors.forename: M-P
authors.initials: MP
authors.lastname: Bonnet
authors.forename: M
authors.initials: M
authors.lastname: Bruyère
authors.forename: M
authors.initials: M
authors.lastname: Moufouki
authors.forename: A
authors.initials: A
authors.lastname: De la Dorie
authors.forename: D
authors.initials: D
authors.lastname: Benhamou
mesh_terms: D000138:Acidosis / Q000139:chemically induced; D016362:Analgesia, Obstetrical / Q000009:adverse effects* / Q000379:methods; D000767:Anesthesia, Epidural / Q000009:adverse effects; D000768:Anesthesia, General / Q000009:adverse effects; D000773:Anesthesia, Obstetrical / Q000009:adverse effects* / Q000379:methods; D000775:Anesthesia, Spinal / Q000009:adverse effects; D000779:Anesthetics, Local / Q000009:adverse effects* / Q000493:pharmacokinetics; D001919:Bradycardia / Q000139:chemically induced; D001921:Brain / Q000187:drug effects / Q000196:embryology; D002585:Cesarean Section; D004809:Ephedrine / Q000009:adverse effects; D005260:Female; D005315:Fetal Diseases / Q000139:chemically induced; D005316:Fetal Distress / Q000209:etiology*; D005318:Fetal Heart / Q000187:drug effects; D006801:Humans; D007022:Hypotension / Q000188:drug therapy; D007231:Infant, Newborn; D007278:Injections, Spinal / Q000009:adverse effects; D009294:Narcotics / Q000009:adverse effects* / Q000493:pharmacokinetics; D007744:Obstetric Labor Complications / Q000188:drug therapy; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D014469:Umbilical Arteries
chemical_list: D000779:Anesthetics, Local; D009294:Narcotics; D004809:Ephedrine