title: TASSEL: software for association mapping of complex traits in diverse samples.
abstract: Association analyses that exploit the natural diversity of a genome to map at very high resolutions are becoming increasingly important. In most studies, however, researchers must contend with the confounding effects of both population and family structure. TASSEL (Trait Analysis by aSSociation, Evolution and Linkage) implements general linear model and mixed linear model approaches for controlling population and family structure. For result interpretation, the program allows for linkage disequilibrium statistics to be calculated and visualized graphically. Database browsing and data importation is facilitated by integrated middleware. Other features include analyzing insertions/deletions, calculating diversity statistics, integration of phenotypic and genotypic data, imputing missing data and calculating principal components.
authors.affiliation: United States Department of Agriculture-Agricultural Research Service, Institute for Genomic Diversity, Cornell University, Ithaca, New York, USA. pjb39@cornell.edu
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Bradbury
authors.forename: Zhiwu
authors.initials: Z
authors.lastname: Zhang
authors.forename: Dallas E
authors.initials: DE
authors.lastname: Kroon
authors.forename: Terry M
authors.initials: TM
authors.lastname: Casstevens
authors.forename: Yogesh
authors.initials: Y
authors.lastname: Ramdoss
authors.forename: Edward S
authors.initials: ES
authors.lastname: Buckler
mesh_terms: D000465:Algorithms; D002874:Chromosome Mapping / Q000379:methods*; D004252:DNA Mutational Analysis / Q000379:methods*; D003627:Data Interpretation, Statistical; D014644:Genetic Variation / Q000235:genetics*; D015810:Linkage Disequilibrium / Q000235:genetics*; D040641:Quantitative Trait Loci / Q000235:genetics*; D012984:Software