title: Association of ICAM3 genetic variant with severe acute respiratory syndrome.
abstract: Genetic polymorphisms have been demonstrated to be associated with vulnerability to human infection. ICAM3, an intercellular adhesion molecule important for T cell activation, and FCER2 (CD23), an immune response gene, both located on chromosome 19p13.3, were investigated for host genetic susceptibility and association with clinical outcome. A case-control study based on 817 patients with confirmed severe acute respiratory syndrome (SARS), 307 health care worker control subjects, 290 outpatient control subjects, and 309 household control subjects unaffected by SARS from Hong Kong was conducted to test for genetic association. No significant association to susceptibility to SARS infection caused by the novel coronavirus (SARS-CoV) was found for the FCER2 and the ICAM3 single nucleotide polymorphisms. However, patients with SARS homozygous for ICAM3 Gly143 showed significant association with higher lactate dehydrogenase levels (P=.0067; odds ratio [OR], 4.31 [95% confidence interval {CI}, 1.37-13.56]) and lower total white blood cell counts (P=.022; OR, 0.30 [95% CI, 0.10-0.89]) on admission. These findings support the role of ICAM3 in the immunopathogenesis of SARS.
authors.affiliation: Department of Pathology, University of Hong Kong, Queen Mary Hospital, Pokfulam Rd, Hong Kong.
authors.forename: Kelvin Y K
authors.initials: KY
authors.lastname: Chan
authors.forename: Johannes C Y
authors.initials: JC
authors.lastname: Ching
authors.forename: M S
authors.initials: MS
authors.lastname: Xu
authors.forename: Annie N Y
authors.initials: AN
authors.lastname: Cheung
authors.forename: Shea-Ping
authors.initials: SP
authors.lastname: Yip
authors.forename: Loretta Y C
authors.initials: LY
authors.lastname: Yam
authors.forename: Sik-To
authors.initials: ST
authors.lastname: Lai
authors.forename: Chung-Ming
authors.initials: CM
authors.lastname: Chu
authors.forename: Andrew T Y
authors.initials: AT
authors.lastname: Wong
authors.forename: You-Qiang
authors.initials: YQ
authors.lastname: Song
authors.forename: Fang-Ping
authors.initials: FP
authors.lastname: Huang
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.forename: P H
authors.initials: PH
authors.lastname: Chung
authors.forename: G M
authors.initials: GM
authors.lastname: Leung
authors.forename: Eudora Y D
authors.initials: EY
authors.lastname: Chow
authors.forename: Eric Y T
authors.initials: EY
authors.lastname: Chan
authors.forename: Jane C K
authors.initials: JC
authors.lastname: Chan
authors.forename: Hextan Y S
authors.initials: HY
authors.lastname: Ngan
authors.forename: Paul
authors.initials: P
authors.lastname: Tam
authors.forename: Li-Chong
authors.initials: LC
authors.lastname: Chan
authors.forename: Pak
authors.initials: P
authors.lastname: Sham
authors.forename: Vera S F
authors.initials: VS
authors.lastname: Chan
authors.forename: Malik
authors.initials: M
authors.lastname: Peiris
authors.forename: Steve C L
authors.initials: SC
authors.lastname: Lin
authors.forename: Ui-Soon
authors.initials: US
authors.lastname: Khoo
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015703:Antigens, CD / Q000235:genetics*; D016022:Case-Control Studies; D015815:Cell Adhesion Molecules / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood*; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D045169:Severe Acute Respiratory Syndrome / Q000235:genetics* / Q000503:physiopathology
chemical_list: D015703:Antigens, CD; D015815:Cell Adhesion Molecules; C483616:ICAM3 protein, human; D007770:L-Lactate Dehydrogenase