title: Fabrication of porous bioceramics with porosity gradients similar to the bimodal structure of cortical and cancellous bone.
abstract: The aim of this study was to fabricate porous implant materials with graded pore structures similar to the bimodal structure of cortical and cancellous bone. Porous hydroxyapatite/tricalcium phosphate (HA/TCP) bioceramics with interconnected porosity and controlled pore sizes required to simulate natural bone tissue morphology were fabricated by a novel technique of vacuum impregnation of reticulated polymeric foams with ceramic slip. Functionally gradient materials (FGMs) with porosity gradients were made by joining different pore per inch (ppi) foams together by either stitching or pressfitting to form templates. Post production, no defects could be seen at the interface between the two different porosity sections. The macropore sizes of the HA/TCP bioceramics were larger than 100 mum which is appropriate for bone ingrowth. A sample with a graded porous structure which is close to the human bone morphology was also developed. The two component structures were conspicuously different but joined together firmly. Four point bend testing of FGM samples showed them to have similar mechanical properties to homogeneous ceramics based on foam templates with uniform pore sizes, with no evidence of interfacial weakness. Many potential biomedical applications could be developed utilising graded porous structures. The ease of processing will make it possible to fabricate a range of complex shapes for different applications.
authors.affiliation: Centre for Orthopaedic Biomechanics, Department of Mechanical Engineering, University of Bath, Claverton Down, Bath BA2 7AY, UK.
authors.forename: Y H
authors.initials: YH
authors.lastname: Hsu
authors.forename: I G
authors.initials: IG
authors.lastname: Turner
authors.forename: A W
authors.initials: AW
authors.lastname: Miles
mesh_terms: D018786:Bone Substitutes / Q000138:chemical synthesis* / Q000737:chemistry*; D001842:Bone and Bones / Q000737:chemistry*; D002130:Calcium Phosphates / Q000138:chemical synthesis / Q000737:chemistry; D002516:Ceramics / Q000138:chemical synthesis*; D019245:Compressive Strength; D006801:Humans; D006882:Hydroxyapatites / Q000138:chemical synthesis / Q000737:chemistry; D008954:Models, Biological; D016348:Osseointegration; D016062:Porosity
chemical_list: D018786:Bone Substitutes; D002130:Calcium Phosphates; D006882:Hydroxyapatites; C094280:hydroxyapatite-tricalciumphosphate composite