Diabetic cardiomyopathy revisited.
Diabetes mellitus increases the risk of heart failure independently of underlying coronary artery disease, and many believe that diabetes leads to cardiomyopathy. The underlying pathogenesis is partially understood. Several factors may contribute to the development of cardiac dysfunction in the absence of coronary artery disease in diabetes mellitus. This review discusses the latest findings in diabetic humans and in animal models and reviews emerging new mechanisms that may be involved in the development and progression of cardiac dysfunction in diabetes.
Boudina
Sihem
S
Division of Endocrinology, Metabolism and Diabetes and Program in Human Molecular Biology and Genetics, University of Utah School of Medicine, Salt Lake City 84112, USA.
Abel
E Dale
ED
D000818:Animals; D002118:Calcium / Q000378:metabolism; D009202:Cardiomyopathies / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology / Q000517:prevention & control; D048909:Diabetes Complications / Q000453:epidemiology / Q000503:physiopathology* / Q000517:prevention & control; D003921:Diabetes Mellitus, Experimental / Q000150:complications / Q000503:physiopathology; D003971:Diastole; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D006333:Heart Failure / Q000453:epidemiology / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control; D006706:Homeostasis; D006801:Humans; D051379:Mice; D008817:Mice, Mutant Strains; D008929:Mitochondria, Heart / Q000502:physiology; D023421:Models, Animal; D018384:Oxidative Stress; D047493:PPAR alpha / Q000378:metabolism; D051381:Rats; D011924:Rats, Zucker; D012084:Renin-Angiotensin System / Q000502:physiology; D018487:Ventricular Dysfunction, Left / Q000209:etiology / Q000503:physiopathology
D005230:Fatty Acids, Nonesterified; D047493:PPAR alpha; D002118:Calcium