title: (18)F-FDG PET database of longitudinally confirmed healthy elderly individuals improves detection of mild cognitive impairment and Alzheimer's disease.
abstract: The normative reference sample is crucial for the diagnosis of Alzheimer's disease (AD) with automated (18)F-FDG PET analysis. We tested whether an (18)F-FDG PET database of longitudinally confirmed healthy elderly individuals ("normals," or NLs) would improve diagnosis of AD and mild cognitive impairment (MCI).
  
  
  METHODS
  Two (18)F-FDG PET databases of 55 NLs with 4-y clinical follow-up examinations were created: one of NLs who remained NL, and the other including a fraction of NLs who declined to MCI at follow-up. Each (18)F-FDG PET scan of 19 NLs, 37 MCI patients, and 33 AD patients was z scored using automated voxel-based comparison to both databases and examined for AD-related abnormalities.
  
  
  RESULTS
  Our database of longitudinally confirmed NLs yielded 1.4- to 2-fold higher z scores than did the mixed database in detecting (18)F-FDG PET abnormalities in both the MCI and the AD groups. (18)F-FDG PET diagnosis using the longitudinal NL database identified 100% NLs, 100% MCI patients, and 100% AD patients, which was significantly more accurate for MCI patients than with the mixed database (100% NLs, 68% MCI patients, and 94% AD patients identified).
  
  
  CONCLUSIONS
  Our longitudinally confirmed NL database constitutes reliable (18)F-FDG PET normative values for MCI and AD.
authors.affiliation: New York University School of Medicine, New York, New York 10016, USA. lisa.mosconi@med.nyu.edu
authors.forename: Lisa
authors.initials: L
authors.lastname: Mosconi
authors.forename: Wai Hon
authors.initials: WH
authors.lastname: Tsui
authors.forename: Alberto
authors.initials: A
authors.lastname: Pupi
authors.forename: Susan
authors.initials: S
authors.lastname: De Santi
authors.forename: Alexander
authors.initials: A
authors.lastname: Drzezga
authors.forename: Satoshi
authors.initials: S
authors.lastname: Minoshima
authors.forename: Mony J
authors.initials: MJ
authors.lastname: de Leon
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000000981:diagnostic imaging*; D016208:Databases, Factual; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography / Q000379:methods; D019275:Radiopharmaceuticals; D012016:Reference Values
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18