Models wagging the dog: are circuits constructed with disparate parameters?
In a recent article, Prinz, Bucher, and Marder (2004) addressed the fundamental question of whether neural systems are built with a fixed blueprint of tightly controlled parameters or in a way in which properties can vary largely from one individual to another, using a database modeling approach. Here, we examine the main conclusion that neural circuits indeed are built with largely varying parameters in the light of our own experimental and modeling observations. We critically discuss the experimental and theoretical evidence, including the general adequacy of database approaches for questions of this kind, and come to the conclusion that the last word for this fundamental question has not yet been spoken.
Nowotny
Thomas
T
Institute for Nonlinear Science, University of California, San Diego, La Jolla, CA 92093-0402, USA. T.Nowotny@sussex.ac.uk
Szücs
Attila
A
Levi
Rafael
R
Selverston
Allen I
AI
D015761:4-Aminopyridine / Q000494:pharmacology; D000200:Action Potentials / Q000187:drug effects / Q000502:physiology; D000818:Animals; D016208:Databases, Factual; D005246:Feedback; D017952:Ganglia, Invertebrate / Q000166:cytology; D007473:Ion Channels / Q000187:drug effects / Q000502:physiology; D008959:Models, Neurological; D009415:Nerve Net / Q000502:physiology*; D016571:Neural Networks, Computer; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D033521:Palinuridae; D026902:Potassium Channel Blockers / Q000494:pharmacology; D013997:Time Factors
D007473:Ion Channels; D026902:Potassium Channel Blockers; D015761:4-Aminopyridine