title: Lignans, an amide and anti-platelet activities from Piper philippinum.
abstract: Investigation of the stem extract of Piper philippinum led to isolation of eight compounds, piperphilippinins I-VI (1-6), philippinamide (7), and (+)-bornyl caffeate (8), together with 26 known compounds. Among the isolates, (-)-3',4'-O,O-demethylenehinokinin (10) and 3,4-methylenedioxycinnamaldehyde (23) showed anti-platelet activities in vitro.
authors.affiliation: Graduate Institute of Pharmaceutical Sciences, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan, ROC.
authors.forename: Yu-Chang
authors.initials: YC
authors.lastname: Chen
authors.forename: Chang-Hui
authors.initials: CH
authors.lastname: Liao
authors.forename: Ih-Sheng
authors.initials: IS
authors.lastname: Chen
mesh_terms: D000577:Amides / Q000302:isolation & purification / Q000494:pharmacology; D000818:Animals; D001792:Blood Platelets / Q000187:drug effects; D066298:In Vitro Techniques; D017705:Lignans / Q000302:isolation & purification / Q000494:pharmacology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D031701:Piper / Q000737:chemistry*; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology; D018547:Plant Stems / Q000737:chemistry; D010975:Platelet Aggregation Inhibitors / Q000302:isolation & purification / Q000494:pharmacology; D011817:Rabbits
chemical_list: D000577:Amides; D017705:Lignans; D010936:Plant Extracts; D010975:Platelet Aggregation Inhibitors