Increased vascular resistance and not salt retention characterizes cyclosporine A-induced hypertension: report in an anuric patient.
Cyclosporine A (CsA) use is associated with hypertension in most solid-organ transplant recipients. The mechanisms of CsA-induced hypertension have not been fully elucidated and are still controversial. We present a case of CsA-induced hypertension who was anuric and receiving hemodialysis, and in whom noninvasive cardiothoracic bioimpedence revealed elevated systemic vascular resistance without evidence of fluid-volume overload. We briefly discuss the possible mechanisms of CsA-induced hypertension in light of this information.
Wahba
I M
IM
Department of Medicine, Division of Nephrology and Hypertension, Oregon Health & Science University, Portland, OR, USA. Wahbai@ohsu.edu
Bennett
W M
WM
D000368:Aged; D001002:Anuria / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy; D001794:Blood Pressure / Q000187:drug effects; D016572:Cyclosporine / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006084:Graft Rejection / Q000517:prevention & control*; D006801:Humans; D006973:Hypertension / Q000139:chemically induced* / Q000503:physiopathology; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use; D007676:Kidney Failure, Chronic / Q000601:surgery; D016030:Kidney Transplantation / Q000009:adverse effects*; D006435:Renal Dialysis; D012965:Sodium Chloride / Q000378:metabolism*; D014655:Vascular Resistance / Q000187:drug effects / Q000502:physiology*
D007166:Immunosuppressive Agents; D012965:Sodium Chloride; D016572:Cyclosporine