Genetic linkage and association analyses for trait mapping in Plasmodium falciparum.
Genetic studies of Plasmodium falciparum laboratory crosses and field isolates have produced valuable insights into determinants of drug responses, antigenic variation, disease virulence, cellular development and population structures of these virulent human malaria parasites. Full-genome sequences and high-resolution haplotype maps of SNPs and microsatellites are now available for all 14 parasite chromosomes. Rapidly increasing genetic and genomic information on Plasmodium parasites, mosquitoes and humans will combine as a rich resource for new advances in our understanding of malaria, its transmission and its manifestations of disease.
Su
Xinzhuan
X
Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike Bethesda, Maryland 20892-8132, USA.
Hayton
Karen
K
Wellems
Thomas E
TE
D000818:Animals; D005075:Biological Evolution; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D017125:Genes, Protozoan; D008040:Genetic Linkage; D018503:Genome, Protozoan; D006801:Humans; D015810:Linkage Disequilibrium; D016778:Malaria, Falciparum / Q000235:genetics; D018895:Microsatellite Repeats; D010963:Plasmodium falciparum / Q000235:genetics*