title: Comparative study of high-resolution microimaging with 30-MHz scanner for evaluating cardiac function in mice.
abstract: BACKGROUND
  The accurate assessment of cardiac function in mice is challenging because of their small heart size and rapid heart rate.
  
  
  METHODS
  We examined the usefulness of novel high-resolution echocardiography (HRE) with a 30-MHz transducer in evaluating cardiac function in 20 mice compared with conventional echocardiography (CE) with a 13-MHz transducer. The left ventricular (LV) regional wall motion (RWM), LV end-diastolic dimension, fractional shortening, anterior LV wall thickness, E/A, and myocardial performance index were assessed.
  
  
  RESULTS
  RWM analysis was more feasible by HRE than by CE (P < .05). Interobserver agreement in RWM analysis and correlation in LV end-diastolic dimension, fractional shortening, anterior LV wall thickness, E/A, and myocardial performance index were all better with HRE than CE.
  
  
  CONCLUSIONS
  HRE is superior to CE in assessing LV function in mice. HRE is potentially a useful method for accurate assessment of cardiac function in various mice models.
authors.affiliation: Department of Medicine, Division of Cardiology, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA. OkajimaKazue@aol.com
authors.forename: Kazue
authors.initials: K
authors.lastname: Okajima
authors.forename: Yukio
authors.initials: Y
authors.lastname: Abe
authors.forename: Kohei
authors.initials: K
authors.lastname: Fujimoto
authors.forename: Kana
authors.initials: K
authors.lastname: Fujikura
authors.forename: Erin E
authors.initials: EE
authors.lastname: Girard
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Asai
authors.forename: Susan H
authors.initials: SH
authors.lastname: Kwon
authors.forename: Zhezhen
authors.initials: Z
authors.lastname: Jin
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Minoru
authors.initials: M
authors.lastname: Yoshiyama
authors.forename: Shunichi
authors.initials: S
authors.lastname: Homma
mesh_terms: D000818:Animals; D003971:Diastole; D004195:Disease Models, Animal; D004452:Echocardiography / Q000379:methods*; D006352:Heart Ventricles / Q000000981:diagnostic imaging* / Q000503:physiopathology; D007089:Image Enhancement / Q000379:methods*; D008297:Male; D051379:Mice; D009200:Myocardial Contraction / Q000502:physiology*; D009203:Myocardial Infarction / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology; D015588:Observer Variation; D015203:Reproducibility of Results; D012720:Severity of Illness Index; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology*