Experimental strabismus surgery using triamcinolone: outcomes and effects on inflammatory response.
OBJECTIVE
To evaluate the efficiency of triamcinolone (TRI) in limiting the postoperative inflammatory response and scarring after strabismus surgery.


METHODS
A prospective, two-stage, masked, controlled trial was conducted. In the first stage, the inflammatory response at the extraocular muscle reattachment site was analyzed after superior rectus recession in ten rabbits. In the second stage, TRI (40 mg/ml) was applied during surgery to the eyes of 16 rabbits with superior rectus recession. As a control, contralateral eyes were treated with physiological saline. Fifteen days later, exenteration was performed, and the sites of muscle reattachment were processed for histological examinations. The sums of the areas of the granulomas in the extraocular muscle reattachment sites of control and treated eyes were compared.


RESULTS
There was a preliminary inhibition effect of TRI on the inflammatory response of treated eyes compared with that of control eyes.


CONCLUSIONS
In the conditions of conducting this study the introperative use of TRI was effective in controlling the postoperative inflammatory response in rabbit eyes after extraocular muscle surgery.
de Carvalho
Luis Eduardo Morato Rebouças
LE
Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brasil. adocarvalho@uol.com.br
Alves
Milton Ruiz
MR
da Silva
Maria Antonieta Longo Galvão
MA
Gaal Vadas
Marcelo Francisco
MF
D000818:Animals; D004195:Disease Models, Animal; D004812:Epidemiologic Methods; D005355:Fibrosis / Q000175:diagnosis / Q000209:etiology / Q000473:pathology; D005938:Glucocorticoids / Q000009:adverse effects / Q000627:therapeutic use*; D006099:Granuloma / Q000175:diagnosis / Q000209:etiology / Q000473:pathology; D009801:Oculomotor Muscles / Q000187:drug effects / Q000473:pathology / Q000601:surgery; D011817:Rabbits; D012965:Sodium Chloride / Q000627:therapeutic use; D013285:Strabismus / Q000473:pathology / Q000601:surgery*; D014222:Triamcinolone Acetonide / Q000009:adverse effects / Q000627:therapeutic use*; D014945:Wound Healing
D005938:Glucocorticoids; D012965:Sodium Chloride; D014222:Triamcinolone Acetonide