[Effect of mexidol on hemopoietic system in conditions of an emotional stress after exposure to ionizing radiation].
The emotional stress after an irradiation can complicate the current of radiative defeats. At an emotional stress developing in early terms after an irradiation in low doses, are reduced adaptive and compensator capabilities of hemopoietic system. The emotional stress after a lethal dose irradiation inhibits the post-radiation recovery of haemopoiesis, aggravates the course of acute radiation disease and decreases the efficiency of the radioprotector--indralin. These disorders are especially pronounced under a prolonged and intensive stress. The use of the mexidol, having anxiolytic and antistress by activity, made it possible to arrest completely disturbances in the development of adaptive reactions to stress in the blood system and to normalize its compensatory potentialities in animals under conditions of combined influence of intensive long-term emotional stress and of low-dose irradiation. In the case of lethally irraiated animals, the treatment of stressed animals with mexidol favorably influenced the course of acute radiation disease, enhanced recovery processes in the blood system. Under these conditions, the use of mexidol completely removes the negative effect of emotional stress in indralin-protected animals. The pharmacological correction by mexidol from displays of an intensive emotional stress, developing after an irradiation in various doses, can be a part in system of medical measures.
Moroz
B B
BB
Deshevoĭ
Iu B
IuB
Voronina
T A
TA
Lyrshchikova
A V
AV
Lebedev
V G
VG
D000818:Animals; D004359:Drug Therapy, Combination; D005720:Gamma Rays; D006410:Hematopoiesis / Q000187:drug effects / Q000528:radiation effects; D008297:Male; D010636:Phenols / Q000008:administration & dosage / Q000627:therapeutic use; D010847:Picolines / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D011619:Psychotropic Drugs / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D011829:Radiation Dosage; D011833:Radiation Injuries, Experimental / Q000097:blood / Q000209:etiology / Q000517:prevention & control; D011837:Radiation-Protective Agents / Q000008:administration & dosage / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D013315:Stress, Psychological / Q000097:blood / Q000150:complications / Q000188:drug therapy*
D010636:Phenols; D010847:Picolines; D011619:Psychotropic Drugs; D011837:Radiation-Protective Agents; C086896:indralin; C070020:emoxypine succinate