title: Synthesis of novel antitumoural analogues of dysidiolide from ent-halimic acid.
abstract: Several sesterterpenolides analogues of dysidiolide have been synthesized and their in vitro antitumoural activity against human HeLa, A549, HT-29 and HL-60 carcinoma cells is presented. The proliferation inhibition data showed a significant antitumour activity of the compounds 1b, 2a, 2b, 3a, 3b, 4a, 4b, 5, inhibiting proliferation of distinct cancer cell types with an IC(50) in the low micromolar range.
authors.affiliation: Departamento de Química Orgánica, Facultad de Ciencias Químicas, Universidad de Salamanca, Plaza de los Caídos 1-5, Salamanca, Spain. ismarcos@usal.es
authors.forename: I S
authors.initials: IS
authors.lastname: Marcos
authors.forename: M A
authors.initials: MA
authors.lastname: Escola
authors.forename: R F
authors.initials: RF
authors.lastname: Moro
authors.forename: P
authors.initials: P
authors.lastname: Basabe
authors.forename: D
authors.initials: D
authors.lastname: Diez
authors.forename: F
authors.initials: F
authors.lastname: Sanz
authors.forename: F
authors.initials: F
authors.lastname: Mollinedo
authors.forename: J
authors.initials: J
authors.lastname: de la Iglesia-Vicente
authors.forename: B G
authors.initials: BG
authors.lastname: Sierra
authors.forename: J G
authors.initials: JG
authors.lastname: Urones
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000447:Aldehydes / Q000737:chemistry; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D006900:Hydroxylation; D007659:Ketones / Q000737:chemistry; D008958:Models, Molecular; D015394:Molecular Structure; D054830:Sesterterpenes; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D013729:Terpenes / Q000737:chemistry*
chemical_list: D000447:Aldehydes; D000970:Antineoplastic Agents; D007659:Ketones; D054830:Sesterterpenes; D013729:Terpenes; C004511:butenolide; C121906:dysidiolide; D015107:4-Butyrolactone