Threshold Dose--Response Model--RIP: 1911 to 2006.
This essay represents a serious but fictional obituary of a scientific concept called the Threshold Dose-Response Model, which has long dominated the fields of toxicology and the broader biomedical sciences. Recent evidence indicates that the Threshold Dose-Response Model has long outlived its utility to predict low-dose effects. In fact, so poorly does this model predict low-dose responses that the idea arose that it should receive a symbolic burial recounting its achievements and failings, hence this obituary.
Calabrese
Edward J
EJ
Environmental Health Sciences, University of Massachusetts, North Pleassant St Amherst MA 01003, USA. edwardc@schoolph.umass.edu
D004305:Dose-Response Relationship, Drug; D049673:History, 20th Century; D049674:History, 21st Century; D008954:Models, Biological; D010600:Pharmacology / Q000266:history / Q000379:methods*; D018570:Risk Assessment / Q000266:history / Q000379:methods; D014116:Toxicology / Q000266:history / Q000379:methods*