title: Open trial of family-based treatment for full and partial anorexia nervosa in adolescence: evidence of successful dissemination.
abstract: OBJECTIVE
  There is a paucity of evidence-based interventions for anorexia nervosa (AN). An innovative family-based treatment (FBT), developed at the Maudsley Hospital and recently put in manual form, has shown great promise for adolescents with AN. Unlike traditional treatment approaches, which promote sustained autonomy around food, FBT temporarily places the parents in charge of weight restoration. This aim of this open trial was to investigate the feasibility and effectiveness of delivering FBT at a site beyond the treatment's origin and manualization.
  
  
  METHODS
  Twenty adolescents (ages 12-17) with AN or subthreshold AN were treated with up to 1 year of FBT using the published treatment manual. Outcome indices included the percentage of ideal body weight, menstrual status, the Eating Disorder Examination (EDE) subscales scores, and the Children's Depression Rating Scale-Revised score.
  
  
  RESULTS
  Of the 20 patients recruited, 15 (75%) completed a full course of treatment. Intent-to-treat analyses showed significant improvement over time in the percentage of ideal body weight (t = -4.46, p =.000), menstrual status (p =.002), EDE Restraint (z = -3.02, p =.003), EDE Eating Concern (z = -2.10, p =.04), but not in EDE Shape Concern or Weight Concern subscales or Children's Depression Rating Scale-Revised score.
  
  
  CONCLUSIONS
  This open trial provides evidence that FBT can be successfully disseminated, replicating the high retention rates and significant improvement in the psychopathology of adolescent AN seen at the original sites.
authors.affiliation: Mount Sinai School of Medicine, New York, NY 10029, USA. katharine.loeb@mssm.edu
authors.forename: Katharine L
authors.initials: KL
authors.lastname: Loeb
authors.forename: B Timothy
authors.initials: BT
authors.lastname: Walsh
authors.forename: James
authors.initials: J
authors.lastname: Lock
authors.forename: Daniel
authors.initials: D
authors.lastname: le Grange
authors.forename: Jennifer
authors.initials: J
authors.lastname: Jones
authors.forename: Sue
authors.initials: S
authors.lastname: Marcus
authors.forename: James
authors.initials: J
authors.lastname: Weaver
authors.forename: Ilyse
authors.initials: I
authors.lastname: Dobrow
mesh_terms: D000293:Adolescent; D000465:Algorithms; D000856:Anorexia Nervosa / Q000523:psychology* / Q000628:therapy*; D001835:Body Weight; D002648:Child; D005196:Family Therapy / Q000379:methods*; D005240:Feasibility Studies; D001068:Feeding and Eating Disorders / Q000523:psychology / Q000628:therapy; D005260:Female; D006801:Humans; D008297:Male; D008370:Manuals as Topic; D008598:Menstruation; D012107:Research Design; D012153:Retention, Psychology