[Evaluation of the climacteric symptomatology modifications and clinical-instrumental parameters in women in physiological menopause treated with hormone replacement therapy with nomegestrol acetate and in surgical menopause treated with estrogen replacement therapy. Part I].
OBJECTIVE
The purpose of this study was to evaluate the effect of the use of nomegestrol acetate in relation to climacteric symptomatology, at clinical, instrumental and hematochemical levels. Regarding patients in physiological menopause treated with hormone replacement therapy (HRT) compared to patients in surgical menopause treated with hemihydrate estradiol hormone replacement therapy (ERT) administered transdermally.


METHODS
Sixty women in menopause for at least 6 months between the ages of 40 and 55 years were enrolled in the study; 30 women were given HRT with nomegestrol acetate and 30 were only given ERT as they had undergone a total hysterectomy with a bilateral adnexectomy. The standards for inclusion were levels of FSH >or= to 30 UI, levels of 17Beta-estradiol <or= to 50 pg/mL, in women who hadn't had any hormonal treatment for osteoporosis in the last 6 months. The women were tested at the beginning of the therapy, at 6 months and after 12 months.


RESULTS
In the patients treated with nomegestrol acetate the climacteric symptoms were reduced or had disappeared and the quality of life both as to relationship and sexuality had improved after 12 months. In the group of women who had only been treated with ERT there was a significant reduction of the climacteric symptoms and the subjective symptoms had improved within 6 months and the reduction continued at the follow-up at 12 months.


CONCLUSIONS
This study confirms the value of hormone replacement therapy in both groups, underlining a more remarkable improvement in the patients treated with nomegestrol acetate than in those treated with estrogens only.
Savoca
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Unità per gli Studi sulla Menopausa, Clinica Ostetrica e Ginecologica II, Dipartimento di Ostetricia, Ginecologia e Scienze Radiologiche, Azienda Ospedaliero-Universitaria Gaspare Rodolico, Policlinico di Catania, Catania. savoca3@interfree.it
D'Agosta
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S
Lombardo
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G
D000328:Adult; D002979:Climacteric / Q000187:drug effects; D004359:Drug Therapy, Combination; D004717:Endometrium / Q000187:drug effects; D004958:Estradiol / Q000627:therapeutic use*; D015914:Estrogen Replacement Therapy / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008535:Megestrol / Q000627:therapeutic use*; D008593:Menopause / Q000187:drug effects*; D008875:Middle Aged; D009649:Norpregnadienes / Q000627:therapeutic use*; D011788:Quality of Life; D016896:Treatment Outcome
D009649:Norpregnadienes; D004958:Estradiol; C038501:nomegestrol acetate; D008535:Megestrol