Regulation of GATA1 gene expression.
GATA1 is one of the most fascinating transcription factors for biologists. It regulates many haematopoietic genes and interacts with a number of other transcription factors. Its functions are mostly conserved among vertebrates. Upon disruption of the GATA1 gene, mice show a drastic bloodless phenotype. GATA1 knockdown mice are predisposed to tumour development, the extent of which varies depending on the level of knockdown. When GATA1 is overexpressed, certain cells face an altered cell fate. These observations suggest the importance of regulation on the expression level and timing of GATA1. Deciphering such regulation is the key to understanding the commitment and differentiation of blood cells. There are so many splendid reviews describing GATA1 as a transcription factor. We therefore focus our topics on GATA1 gene regulation in this review.
Kobayashi
Makoto
M
Institute of Basic Medical Sciences, Graduate School of Comprehensive Human Sciences; ERATO Environmental Response Project, Japan Science and Technology Agency, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8575, Japan. makobayashi@md.tsukuba.ac.jp
Yamamoto
Masayuki
M
D000818:Animals; D002454:Cell Differentiation; D050982:GATA1 Transcription Factor / Q000235:genetics* / Q000378:metabolism; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D006801:Humans; D051379:Mice; D008954:Models, Biological; D050436:Regulatory Elements, Transcriptional; D015534:Trans-Activators / Q000235:genetics / Q000378:metabolism
D050982:GATA1 Transcription Factor; D015534:Trans-Activators