Titanocene(II)-promoted, one-pot, three-component coupling of thioacetals, alkynyl sulfones, and carbonyl compounds: highly stereoselective formation of tert-homopropargyl alcohols.
Titanocene alkylidene complexes, generated by desulfurizative titanation of thioacetals with Cp2Ti[P(OEt)3]2, reacted with alkynyl methyl sulfones to produce organotitanium species, which gave tert-homopropargyl alcohols with high diastereoselectivity on treatment with aromatic and alpha,beta-unsaturated ketones.
Takeda
Takeshi
T
Department of Applied Chemistry, Graduate School of Engineering, Tokyo University of Agriculture and Technology, Koganei, Tokyo 184-8588, Japan. takeda-t@cc.tuat.ac.jp
Ando
Maiko
M
Sugita
Takenori
T
Tsubouchi
Akira
A