Successful reduced-intensity stem cell transplantation with cord blood for a poor-prognosis adult with refractory chronic active epstein-barr virus infection.
A 56-year-old woman with a poor-prognosis chronic active Epstein-Barr virus (CAEBV) infection underwent reduced-intensity stem cell transplantation (RIST) using cryopreserved cord blood (CB). Administration of EBV-seronegative CB cells following a reduced-intensity conditioning regimen was effective and well tolerated. Complete remission with no symptoms, low titers of EBV-related antibodies, and an undetectable level of EBV DNA in peripheral blood mononuclear cells continued for 16 months after RIST. This report is the first of successful RIST with CB for an adult with CAEBV infection. The results also show that a graft-versus-CAEBV effect can be achieved in an allogeneic hematopoietic stem cell transplantation setting.
Nakagawa
Masao
M
Department of Gastroenterology and Hematology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Hashino
Satoshi
S
Takahata
Mutsumi
M
Kawamura
Takahito
T
Fujisawa
Fumie
F
Kahata
Kaoru
K
Kondo
Takeshi
T
Imamura
Masahiro
M
Ando
Sachiko
S
Asaka
Masahiro
M
D002908:Chronic Disease; D036101:Cord Blood Stem Cell Transplantation; D020031:Epstein-Barr Virus Infections / Q000628:therapy*; D005260:Female; D006801:Humans; D008875:Middle Aged; D011379:Prognosis; D012074:Remission Induction; D019172:Transplantation Conditioning