Expression of CD22 on peripheral B cells in patients with rheumatoid arthritis: relation to CD5-positive B cells.
B cells in patients with rheumatoid arthritis (RA) are hyperactivated. Although B cell receptor signal transduction may be affected by various response regulators, CD22 plays an important role as a response regulator of B cells. Therefore, we investigated and examined CD22 expression on peripheral blood B cells of patients with RA. Thirty-two RA patients and 16 controls were enrolled in this study, and CD22 expressions on B cells were analyzed by flow cytometry. In patients with RA, CD22(+) B cells significantly decreased in comparison to the controls (ratio: P < 0.05). However, there was no correlation between this decrease and the clinical data. Interestingly, CD5(+) CD22(-) B cells significantly increased in RA patients. The decrease in CD22(+) B cells and increased in CD5(+)CD22(-) B cells play critical roles in the pathogenesis of RA mediated by the activation of B cells.
Nakiri
Yutaka
Y
Department of Rheumatology and Internal Medicine, Juntendo University, School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. mayuta@hkg.odn.ne.jp
Minowa
Kentarou
K
Suzuki
Jun
J
Mitsuo
Akiko
A
Amano
Hirofumi
H
Morimoto
Shinji
S
Tokano
Yoshiaki
Y
Takasaki
Yoshinari
Y
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018951:Antigens, CD20 / Q000096:biosynthesis; D001172:Arthritis, Rheumatoid / Q000276:immunology* / Q000378:metabolism; D015551:Autoimmunity; D001402:B-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D018956:CD5 Antigens / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical; D012217:Rheumatoid Factor / Q000378:metabolism; D051918:Sialic Acid Binding Ig-like Lectin 2 / Q000096:biosynthesis*
D018951:Antigens, CD20; D018956:CD5 Antigens; D051918:Sialic Acid Binding Ig-like Lectin 2; D012217:Rheumatoid Factor