title: [Implications of serum matrix metalloproteinase-8 elevation in patients with acute coronary syndrome].
abstract: OBJECTIVE
  To study the clinical significance of serum matrix metalloproteinase-8 (MMP-8) concentration variation in patients with acute coronary syndrome (ACS).
  
  
  METHODS
  Enzyme-linked immunosorbent assay (ELISA) was employed to detect serum MMP-8 content in 80 ACS patients, including 43 with acute myocardial infarction (AMI), and 37 with unstable angina pectoris (UAP), as well as in 43 with stable angina pectoris (SAP) cases and 37 control subjects. The risk factors for atherosclerosis pertaining to age, sex, hypertension, body mass index, smoking, family history, diabetes, hyperlipidemia, etc. were evaluated statistically in each case.
  
  
  RESULTS
  Serum MMP-8 concentration was significantly higher in ACS group than in SAP and control groups (Plt;0.01). In ASC group, serum MMP-8 was much higher in AMI patients than in those with UAP (Plt;0.01), but similar between UAP and SAP groups (P>0.05). Logistic regression analysis identified serum MMP-8 concentration as the possible indicator of ACS (B=4.493, P=0.000), and particularly AMI (B=9.961, P=0.000). Linear correlation and linear regression analysis revealed that only neutrophils were associated with serum MMP-8 concentration variation (r=0.274, P=0.001).
  
  
  CONCLUSIONS
  Serum MMP-8 concentration is closely associated with ACS, particularly AMI, and may serve as an indicator for predicting ACS and AMI. Neutrophils may be connected with the variation of serum MMP-8 concentration, but not as the major factor.
authors.affiliation: Key lab of Environmental and disease related gene, Ministy of Education, Department of Cardiology, First Hospital of Xi'an Jiaotong University, Xi'an 710061, China. luckwqh168@126.com
authors.forename: Hua
authors.initials: H
authors.lastname: Qiang
authors.forename: Zhao-Xia
authors.initials: ZX
authors.lastname: Zhou
authors.forename: Ai-Qun
authors.initials: AQ
authors.lastname: Ma
authors.forename: Hua
authors.initials: H
authors.lastname: Cheng
authors.forename: Ping
authors.initials: P
authors.lastname: Zhou
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood* / Q000175:diagnosis; D000787:Angina Pectoris / Q000097:blood / Q000175:diagnosis; D015415:Biomarkers / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D020784:Matrix Metalloproteinase 8 / Q000097:blood*; D009203:Myocardial Infarction / Q000097:blood / Q000175:diagnosis
chemical_list: D015415:Biomarkers; D020784:Matrix Metalloproteinase 8