Ribosomal proteins and the control of alphabeta T lineage development.
How do committed alphabeta T lineage cells undergo rapid proliferation and developmental progression during beta selection? A new study shows that a ribosomal protein, RPL22, promotes the survival of expanding alphabeta T cells.
Murre
Cornelis
C
Division of Biological Sciences, 0366, University of California, San Diego, La Jolla, CA 92093, USA.
D000818:Animals; D019070:Cell Lineage; D051379:Mice; D016601:RNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000032:analysis*; D012269:Ribosomal Proteins / Q000235:genetics / Q000378:metabolism*; D013601:T-Lymphocytes / Q000276:immunology*
D016601:RNA-Binding Proteins; C522051:RPL22 protein, mouse; D016693:Receptors, Antigen, T-Cell, alpha-beta; D012269:Ribosomal Proteins