Association of AGTR1 with 18-month treatment outcome in late-life depression.
OBJECTIVE
Converging lines of evidence implicate vascular factors in late-life depression, and argue that late-life depression is a distinct entity among the mood disorders. The A1166C polymorphism in the angiotensin II receptor, vascular type 1 (AGTR1) gene has been associated with a range of vascular diseases. This study investigated the association of AGTR1 genotype on 18-month treatment outcome in late-life depression.


METHODS
In a large, prospective cohort study, patients with late-life depression received individualized treatment using a standardized algorithm. The authors genotyped participants at the AGTR1 A1166C single nucleotide polymorphism (SNP) using standardized methodology, then used survival analysis to estimate the impact of A1166C and demographic variables on time to remission during 18 months of follow-up.


RESULTS
The hazard ratio for AGTR1 homozygous C/C status was 0.37. The A1166C SNP showed evidence for genotypic and allelic association in a comparison of remitted and unremitted/censored subjects.


CONCLUSIONS
Consistent with its association with numerous vascular disorders, AGTR1 is associated with treatment outcome in late-life depression. Further studies are needed to replicate this finding, and to investigate the impact of other genetic markers of vascular disease on late-life depression outcome.
Kondo
Douglas G
DG
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA.
Speer
Marcy C
MC
Krishnan
K Ranga
KR
McQuoid
Douglas R
DR
Slifer
Susan H
SH
Pieper
Carl F
CF
Billups
Ashley V
AV
Steffens
David C
DC
D017668:Age of Onset; D000368:Aged; D000465:Algorithms; D000075244:Apelin Receptors; D015331:Cohort Studies; D003710:Demography; D003865:Major Depressive Disorder / Q000188:drug therapy* / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D011446:Prospective Studies; D011945:Receptors, Angiotensin / Q000235:genetics; D043562:Receptors, G-Protein-Coupled / Q000235:genetics*; D013997:Time Factors
C104575:APLNR protein, human; D000075244:Apelin Receptors; D011945:Receptors, Angiotensin; D043562:Receptors, G-Protein-Coupled