title: [Study on pharmacokinetics of crebanine injection in rabbits].
abstract: OBJECTIVE
  To develop an HPLC method for the determination of serum level of Crebanine (Cre) and study on the pharmacokinetics of Cre injection in rabbits.
  
  
  METHODS
  To sample blood serum from the rabbits' ears which were injected the Cre by 2.0 mg x kg(-1) at different time and use HPLC to determine the concentration of Cre in it, the pharmacokinetic parameters were accessed by the DAS software.
  
  
  RESULTS
  Cre was fitted to a two compartment open pharmacokinetic model in rabbits. There was no signifiant difference between the male and female rabbits'pharmacokinetic by t-test. The mainly pharmacokinetic parameters were: t1/2alpha = (3. 246 +/-0.222) min, t1/2beta = (36.67+/-5.52) min, Cmax = (1.401 +/- 0.062) mg x L(-1), Vd = (5.928 +/- 0.877) L x kg(-1), Cl = (0. 051 +/-0.003) L x min(-1) x kg(-1).
  
  
  CONCLUSIONS
  This experiment can objectively show the pharmacokinetics regularity of Crebanine injection in rabbits. Crebanine injection was a speeding disposition drug (t1/2 <1 h) and disposed extensively and rapidly in rabbits.
authors.affiliation: Yunnan College of Traditional Chinese Medicine, Kunming 650200, China. yunshuma2@126.com
authors.forename: Yun-Shu
authors.initials: YS
authors.lastname: Ma
authors.forename: Qing-Jie
authors.initials: QJ
authors.lastname: Shang
authors.forename: Yi-Cen
authors.initials: YC
authors.lastname: Bai
authors.forename: Xiao-Fei
authors.initials: XF
authors.lastname: Meng
authors.forename: Shao-Jian
authors.initials: SJ
authors.lastname: Kang
mesh_terms: D000818:Animals; D001060:Aporphines / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid; D005260:Female; D007267:Injections; D008297:Male; D008657:Metabolic Clearance Rate; D010946:Plants, Medicinal / Q000737:chemistry*; D011817:Rabbits; D031607:Stephania / Q000737:chemistry*
chemical_list: D001060:Aporphines; C061009:crebanine