title: Hypertonic saline: first-line therapy for cerebral edema?
abstract: This article highlights the experimental and clinical data, controversies and postulated mechanisms surrounding osmotherapy with hypertonic saline (HS) solutions in the neurocritical care arena and builds on previous reviews on the subject. Special attention is focused on HS therapy on commonly encountered clinical paradigms of acute brain injury including traumatic brain injury (TBI), post-operative "retraction edema", intracranial hemorrhage (ICH), tumor-associated cerebral edema, and ischemia associated with ischemic stroke.
authors.affiliation: Neurosciences Critical Care Division, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
authors.forename: Wendy C
authors.initials: WC
authors.lastname: Ziai
authors.forename: Thomas J K
authors.initials: TJ
authors.lastname: Toung
authors.forename: Anish
authors.initials: A
authors.lastname: Bhardwaj
mesh_terms: D001929:Brain Edema / Q000503:physiopathology / Q000628:therapy*; D001930:Brain Injuries / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D019586:Intracranial Hypertension / Q000503:physiopathology / Q000517:prevention & control; D012449:Safety; D012462:Saline Solution, Hypertonic / Q000627:therapeutic use* / Q000633:toxicity
chemical_list: D012462:Saline Solution, Hypertonic