Cardiovascular diseases and molecular variants of the renin-angiotensin system components in Slovak population.
Cardiovascular diseases associated with molecular variants of individual components of renin-angiotensin system are reported to constitute inherited predisposition in humans. Molecular variant frequencies are race- and population-dependent. We examined frequencies of the M235T variant of angiotensinogen gene and I/D polymorphism of gene for angiotensin-converting enzyme in Slovak population: in hypertensive patients, coronary heart disease (CHD), dilated cardiomyopathy (DCM) and myocardial infarction (MI) patients compared to healthy subjects. Frequency of M235T was significantly increased in hypertensive, CHD and DCM patients compared to controls (0.48 and 0.50 vs. 0.40, p < 0.001). Significant increase in D allele frequency compared to controls was observed in the group of patients after MI (0.58 vs. 0.50, p < 0.001), CHD (0.59 vs. 0.50, p < 0.001) and DCM (0.60 vs. 0.50, p < 0.001). These results correlate with other Caucasian populations. In Slovak population, M235T is associated with increased blood pressure and D allele of ACE gene is associated with MI, chronic CHD and DCM, rather than with hypertension. Our results suggest that in Slovak population, D alelle and M235T variant represent a risk factor for several cardiovascular diseases and these polymorphisms might have a cumulative effect on development of cardiovascular diseases.
Jurkovicova
D
D
Institute of Molecular Physiology and Genetics, Centre of Excellence for Cardiovascular Research of Slovak Academy of Sciences, Bratislava, Slovakia. jurkovicova@savba.ask
Sedlakova
B
B
Riecansky
I
I
Goncalvesova
E
E
Penesova
A
A
Kvetnansky
R
R
Krizanova
O
O
D000368:Aged; D000483:Alleles; D000808:Angiotensinogen / Q000235:genetics* / Q000378:metabolism; D001483:Base Sequence; D001794:Blood Pressure / Q000235:genetics / Q000502:physiology; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D044382:Population Groups; D012083:Renin / Q000235:genetics / Q000378:metabolism; D012084:Renin-Angiotensin System / Q000235:genetics* / Q000502:physiology; D012307:Risk Factors; D018154:Slovakia
D000808:Angiotensinogen; D012083:Renin