Bimorpholine-mediated enantioselective intramolecular and intermolecular aldol condensation.
Monosalts of N-substituted bimorpholine derivatives are efficient organocatalysts in intramolecular and intermolecular aldol reactions. The properties of the catalysts can be tuned either by the selection of an appropriate acid for the salt formation or by the change of a substituent at the nitrogen atom. In aldol condensation, i-Pr-substituted bimorpholine is the most stereoselective catalyst affording products in high yield with enantioselectivities up to 95% ee.
Kanger
Tõnis
T
Faculty of Science, Tallinn University of Technology, Akadeemia tee 15, 12618 Tallinn, Estonia. kanger@chemnet.ee
Kriis
Kadri
K
Laars
Marju
M
Kailas
Tiiu
T
Müürisepp
Aleksander-Mati
AM
Pehk
Tõnis
T
Lopp
Margus
M