Serum visfatin in relation to insulin resistance and markers of hyperandrogenism in lean and obese women with polycystic ovary syndrome.
BACKGROUND
Visfatin, a protein secreted by adipose tissue, is suggested to play a role in pathogenesis of insulin resistance. In polycystic ovary syndrome (PCOS), insulin resistance might be involved in the development of endocrine and metabolic abnormalities. The aim of the study was to asses the relation between serum visfatin concentration and insulin sensitivity and markers of hyperandrogenism in lean and obese PCOS patients.


METHODS
The study group consisted of 70 women with PCOS (23 lean and 47 obese) and 45 healthy women (25 lean and 20 obese). Euglycemic hyperinsulinemic clamp and the measurements of serum visfatin, sex hormones were performed.


RESULTS
The PCOS group had lower insulin sensitivity (P=0.00049) and higher serum visfatin (P=0.047) in comparison to the control group. The decrease in insulin sensitivity was present in both the lean (P=0.019) and obese (P=0.0077) PCOS subjects, whereas increase in serum visfatin was observed only in lean PCOS subjects (P=0.012). In the whole group, serum visfatin was negatively correlated with insulin sensitivity (r=-0.27, P=0.004). This relationship was also observed in the subgroup of lean (r=-0.30, P=0.038), but not obese women. Additionally, in lean women, visfatin was associated with serum testosterone (r=0.47, P=0.002) and free androgen index (r=0.48, P=0.002), independently of other potential confounding factors.


CONCLUSIONS
Visfatin is associated with insulin resistance and markers of hyperandrogenism in lean PCOS patients.
Kowalska
Irina
I
Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, M.C. Sklodowskiej 24a, 15-276 Bialystok, Poland. irinak@poczta.onet.pl
Straczkowski
Marek
M
Nikolajuk
Agnieszka
A
Adamska
Agnieszka
A
Karczewska-Kupczewska
Monika
M
Otziomek
Elzbieta
E
Wolczynski
Slawomir
S
Gorska
Maria
M
D000273:Adipose Tissue / Q000378:metabolism; D015992:Body Mass Index; D001835:Body Weight; D016022:Case-Control Studies; D016207:Cytokines / Q000097:blood* / Q000502:physiology*; D005260:Female; D006801:Humans; D017588:Hyperandrogenism / Q000097:blood* / Q000175:diagnosis; D007328:Insulin / Q000378:metabolism; D007333:Insulin Resistance; D054409:Nicotinamide Phosphoribosyltransferase; D009765:Obesity / Q000097:blood*; D011085:Polycystic Ovary Syndrome / Q000097:blood*
D016207:Cytokines; D007328:Insulin; D054409:Nicotinamide Phosphoribosyltransferase; C085455:nicotinamide phosphoribosyltransferase, human