Effect of exercise training on chromogranin A and relationship to N-ANP and inflammatory cytokines in patients with chronic heart failure.
Exercise training improves functional parameters in patients with congestive heart failure (CHF). The aim of this study was to establish whether exercise training influence the elevated CgA levels in CHF patients. Plasma CgA was determined at baseline and at peak exercise before and after 12 weeks of training in 25 men (mean age 67+/-8 years) with CHF (NYHA functional class II and III). Plasma Chromogranin A (CgA) was significantly elevated in CHF, however without change after the 12 week exercise period. A positive correlation was obtained for CgA versus N-ANP and CgA versus TNFalpha for the patients with poor survival, indicating that in these patients the elevated plasma CgA was more closely connected to the myocardial release of natriuretic peptides and the inflammatory response than to activation of the sympathoadrenergic system.
Larsen
Alf Inge
AI
Helle
Karen B
KB
Christensen
Monika
M
Kvaløy
Jan T
JT
Aarsland
Torbjørn
T
Dickstein
Kenneth
K
D000368:Aged; D009320:Atrial Natriuretic Factor / Q000097:blood*; D053379:Chromogranin A / Q000097:blood*; D002908:Chronic Disease; D016207:Cytokines / Q000097:blood*; D005081:Exercise Therapy; D006333:Heart Failure / Q000097:blood* / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D008297:Male; D011379:Prognosis
D053379:Chromogranin A; D016207:Cytokines; D009320:Atrial Natriuretic Factor