Allosteric enhancers for A1 adenosine receptor.
Allosteric enhancers at the adenosine A(1) receptor have received attention as anti-arrhythmic cardiac agents, and, more recently, as anti-lipolytic agents. In addition, allosteric modulators at the adenosine A(1) receptor have therapeutic potential as analgesics and neuroprotective agents. In particular, the compounds with improved potency as enhancers and reduced antagonist properties are mentioned.
Baraldi
Pier Giovanni
PG
Dipartimento di Scienze Farmaceutiche, Università di Ferrara, Ferrara, Italy. baraldi@unife.it
Iaconinoto
Maria Antonietta
MA
Moorman
Allan R
AR
Carrion
Maria Dora
MD
Cara
Carlota Lopez
CL
Preti
Delia
D
López
Olga Cruz
OC
Fruttarolo
Francesca
F
Tabrizi
Mojgan Aghazade
MA
Romagnoli
Romeo
R
D058907:Adenosine A1 Receptor Agonists; D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism; D006801:Humans; D008968:Molecular Conformation; D043682:Receptor, Adenosine A1 / Q000737:chemistry*; D013329:Structure-Activity Relationship
D058907:Adenosine A1 Receptor Agonists; D043682:Receptor, Adenosine A1; D000242:Cyclic AMP