title: Directionality of EEG synchronization in Alzheimer's disease subjects.
abstract: Is directionality of electroencephalographic (EEG) synchronization abnormal in amnesic mild cognitive impairment (MCI) and Alzheimer's disease (AD)? EEG data were recorded in 64 normal elderly (Nold), 69 amnesic MCI, and 73 mild AD subjects at rest condition (closed eyes). Direction of information flux within EEG functional coupling at electrode pairs was performed by directed transfer function (DTF) at delta (2-4 Hz), theta (4-8 Hz), alpha 1 (8-10 Hz), alpha 2 (10-12 Hz), beta 1 (13-20 Hz), beta 2 (20-30 Hz), and gamma (30-40 Hz). Parietal to frontal direction of the information flux within EEG functional coupling was stronger in Nold than in MCI and/or AD subjects, namely for alpha and beta rhythms. In contrast, the directional flow within inter-hemispheric EEG functional coupling did not discriminate among the three groups. These results suggest that directionality of parieto-to-frontal EEG synchronization is abnormal not only in AD but also in amnesic MCI.
authors.affiliation: Department of Human Physiology and Pharmacology, University La Sapienza, Rome, Italy. claudio.babiloni@uniroma1.it
authors.forename: Claudio
authors.initials: C
authors.lastname: Babiloni
authors.forename: Raffaele
authors.initials: R
authors.lastname: Ferri
authors.forename: Giuliano
authors.initials: G
authors.lastname: Binetti
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Vecchio
authors.forename: Giovanni B
authors.initials: GB
authors.lastname: Frisoni
authors.forename: Bartolo
authors.initials: B
authors.lastname: Lanuzza
authors.forename: Carlo
authors.initials: C
authors.lastname: Miniussi
authors.forename: Flavio
authors.initials: F
authors.lastname: Nobili
authors.forename: Guido
authors.initials: G
authors.lastname: Rodriguez
authors.forename: Francesco
authors.initials: F
authors.lastname: Rundo
authors.forename: Andrea
authors.initials: A
authors.lastname: Cassarino
authors.forename: Francesco
authors.initials: F
authors.lastname: Infarinato
authors.forename: Emanuele
authors.initials: E
authors.lastname: Cassetta
authors.forename: Serenella
authors.initials: S
authors.lastname: Salinari
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Eusebi
authors.forename: Paolo M
authors.initials: PM
authors.lastname: Rossini
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis* / Q000503:physiopathology*; D000647:Amnesia / Q000175:diagnosis* / Q000503:physiopathology*; D001921:Brain / Q000503:physiopathology*; D003072:Cognition Disorders / Q000175:diagnosis* / Q000503:physiopathology*; D003936:Diagnosis, Computer-Assisted / Q000379:methods; D004569:Electroencephalography / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male