Cancer prevention with freeze-dried berries and berry components.
Our laboratory is developing a food-based approach to the prevention of esophageal and colon cancer utilizing freeze-dried berries and berry extracts. Dietary freeze-dried berries were shown to inhibit chemically induced cancer of the rodent esophagus by 30-60% and of the colon by up to 80%. The berries are effective at both the initiation and promotion/progression stages of tumor development. Berries inhibit tumor initiation events by influencing carcinogen metabolism, resulting in reduced levels of carcinogen-induced DNA damage. They inhibit promotion/progression events by reducing the growth rate of pre-malignant cells, promoting apoptosis, reducing parameters of tissue inflammation and inhibiting angiogenesis. On a molecular level, berries modulate the expression of genes involved with proliferation, apoptosis, inflammation and angiogenesis. We have recently initiated clinical trials; results from a toxicity study indicated that freeze-dried black raspberries are well tolerated in humans when administered orally for 7 days at a dose of 45 g per day. Several Phase IIa clinical trials are underway in patients at high risk for esophagus and colon cancer; i.e., Barrett's esophagus, esophageal dysplasia and colonic polyps, to determine if berries will modulate various histological and molecular biomarkers of development of these diseases.
Stoner
Gary D
GD
Division of Hematology and Oncology, Department of Internal Medicine, College of Medicine, The Ohio State University, Innovation Centre, 2001 Polaris Parkway, Columbus, OH 43240, USA. gary.stoner@osumc.edu
Wang
Li-Shu
LS
Zikri
Nancy
N
Chen
Tong
T
Hecht
Stephen S
SS
Huang
Chuanshu
C
Sardo
Christine
C
Lechner
John F
JF
D000818:Animals; D018890:Chemoprevention; D003110:Colonic Neoplasms / Q000517:prevention & control*; D004938:Esophageal Neoplasms / Q000517:prevention & control*; D005612:Freeze Drying; D005638:Fruit / Q000737:chemistry; D006801:Humans; D011208:Powders; D051381:Rats
D011208:Powders