[3 + 2] Cycloaddition of acetylenes with azides to give 1,4-disubstituted 1,2,3-triazoles in a modular flow reactor.
The cycloaddition of acetylenes with azides to give the corresponding 1,4-disubstituted 1,2,3-triazoles is reported using immobilised reagents and scavengers in pre-packed glass tubes in a modular flow reactor.
Smith
Christopher D
CD
Innovative Technology Centre (ACS), Department of Chemistry, Lensfield Road, Cambridge, CB2 1EW, UK.
Baxendale
Ian R
IR
Lanners
Steve
S
Hayward
John J
JJ
Smith
Stephen C
SC
Ley
Steven V
SV
D000480:Alkynes / Q000737:chemistry*; D001386:Azides / Q000737:chemistry*; D002384:Catalysis; D002626:Chemistry, Pharmaceutical / Q000295:instrumentation / Q000379:methods; D003300:Copper / Q000737:chemistry; D004867:Equipment Design; D009682:Magnetic Resonance Spectroscopy; D008956:Models, Chemical; D010455:Peptides / Q000737:chemistry; D014230:Triazoles / Q000737:chemistry*
D000480:Alkynes; D001386:Azides; D010455:Peptides; D014230:Triazoles; D003300:Copper