title: Probabilistic modeling of young children's overall lead exposure in France: integrated approach for various exposure media.
abstract: OBJECTIVE
  Emissions of lead into the environment (and thus its environmental concentrations) have decreased in recent years. We sought to estimate the overall lead exposure of children aged 6 months to 6 years (the population group most exposed and most sensitive to lead) in France through the various media (air, food, water, soils, and dust) and the respective contributions of each medium to the total dose. We have focused on the general population, leaving aside specific risk factors such as deteriorated lead paints.
  
  
  METHODS
  We used the most recent French intake data for food and water, and a daily ingested quantity selected from the literature for soils and dust. Contamination data came from the first total diet study of contaminant levels in France (2000-2001), from regulatory testing of tap water (2004), a literature review of lead in urban soils, and a pilot study (2005) of lead in dust. Air quality monitoring measurements showed that the contribution of air could now be safely ignored. Weekly exposure doses were estimated with Monte Carlo simulations.
  
  
  RESULTS
  Median weekly exposure dose was 7.5 microg/kg bw.week for children aged 6 months to 3 years and 4.7 for those aged from 3-6 years. 95th percentiles were 13.5 and 8.7 microg/kg bw.week. Exposure came mainly from food. The principal uncertainties are associated with quantification limits in food and water, representativeness and traceability of tap water samples, and absence of recent data about urban soil contamination.
  
  
  CONCLUSIONS
  These results differ quite notably from earlier estimates and highlight the need, especially for policy-making purposes, to update exposure measurements for this metal.
authors.affiliation: National School of Public Health, Avenue du Professeur Léon Bernard, 35043 Rennes Cédex, France. philippe.glorennec@ensp.fr
authors.forename: Philippe
authors.initials: P
authors.lastname: Glorennec
authors.forename: Nawel
authors.initials: N
authors.lastname: Bemrah
authors.forename: Alexandra
authors.initials: A
authors.lastname: Tard
authors.forename: Alban
authors.initials: A
authors.lastname: Robin
authors.forename: Barbara
authors.initials: B
authors.lastname: Le Bot
authors.forename: Denis
authors.initials: D
authors.lastname: Bard
mesh_terms: D000393:Air Pollutants / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D004391:Dust / Q000032:analysis; D004781:Environmental Exposure / Q000009:adverse effects; D004785:Environmental Pollutants / Q000032:analysis*; D005602:France; D006801:Humans; D007223:Infant; D007854:Lead / Q000032:analysis*; D007855:Lead Poisoning / Q000517:prevention & control; D015233:Models, Statistical; D018570:Risk Assessment; D012989:Soil Pollutants / Q000032:analysis; D014874:Water Pollutants, Chemical / Q000032:analysis
chemical_list: D000393:Air Pollutants; D004391:Dust; D004785:Environmental Pollutants; D012989:Soil Pollutants; D014874:Water Pollutants, Chemical; D007854:Lead