TRP channel structural biology: new roles for an old fold.
The capsaicin receptor, TRPV1, contributes to thermal and chemical sensitivity of primary afferent neurons of the pain pathway, but many aspects of its regulation remain elusive. In this issue of Neuron, Lishko et al. describe a high-resolution structure of a TRPV1 domain, providing insight into the molecular basis of channel modulation while revealing new functions for a widely expressed protein interaction fold.
Myers
Benjamin R
BR
Department of Physiology, University of California, San Francisco, San Francisco, CA 94143, USA. benjamin.myers@ucsf.edu
Julius
David
D
D000818:Animals; D015394:Molecular Structure; D050916:TRPV Cation Channels / Q000737:chemistry* / Q000502:physiology*
D050916:TRPV Cation Channels; C493921:TRPV1 protein, mouse