Two kinase family dramas.
In this issue, Lietha and colleagues (2007) report the structure of focal adhesion kinase (FAK) and reveal how FAK maintains an autoinhibited state. Together with the structure of another tyrosine kinase, ZAP-70 (Deindl et al., 2007), this work highlights the diversity of mechanisms that nature has evolved within the kinase superfamily to regulate their activity through autoinhibition.
Leonard
Thomas A
TA
Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0580, USA.
Hurley
James H
JH
D004791:Enzyme Inhibitors / Q000494:pharmacology; D051416:Focal Adhesion Protein-Tyrosine Kinases / Q000502:physiology*; D015894:Genome, Human; D006801:Humans; D008958:Models, Molecular; D005810:Multigene Family; D010766:Phosphorylation; D011485:Protein Binding; D011487:Protein Conformation; D017434:Protein Structure, Tertiary; D051746:ZAP-70 Protein-Tyrosine Kinase / Q000502:physiology*; D018909:src Homology Domains
D004791:Enzyme Inhibitors; D051416:Focal Adhesion Protein-Tyrosine Kinases; D051746:ZAP-70 Protein-Tyrosine Kinase