title: PathExpress: a web-based tool to identify relevant pathways in gene expression data.
abstract: PathExpress is a web-based tool developed to interpret gene expression data obtained from microarray experiments by identifying the most relevant metabolic pathways associated with a subset of genes (e.g. differentially expressed genes). A graphical pathway representation permits the visualization of the expressed genes in a functional context. Based on the publicly accessible KEGG Ligand database, PathExpress can be adapted to any organism and is currently available for seven Affymetrix genome arrays. About 20% of the probe sets of each array have been assigned to Enzyme Commission numbers by homology relationship and linked to corresponding metabolic pathways. PathExpress is available at http://bioinfoserver.rsbs.anu.edu.au/utils/PathExpress/.
authors.affiliation: ARC Centre of Excellence for Integrative Legume Research and Bioinformatics Laboratory, Genomic Interactions Group, Research School of Biological Sciences, Australian National University, GPO Box 475, Canberra, ACT 2601 Australia.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Goffard
authors.forename: Georg
authors.initials: G
authors.lastname: Weiller
mesh_terms: D000465:Algorithms; D000818:Animals; D019295:Computational Biology / Q000379:methods*; D003196:Computer Graphics; D003628:Database Management Systems; D004798:Enzymes / Q000737:chemistry*; D020869:Gene Expression Profiling / Q000379:methods; D006801:Humans; D016247:Information Storage and Retrieval / Q000379:methods*; D008660:Metabolism; D008954:Models, Biological; D020411:Oligonucleotide Array Sequence Analysis; D025941:Protein Interaction Mapping / Q000379:methods*; D012984:Software; D014584:User-Computer Interface
chemical_list: D004798:Enzymes