What delay fields tell us about striate cortex.
It is well known that electrical activation of striate cortex (area V1) can disrupt visual behavior. Based on this knowledge, we discovered that electrical microstimulation of V1 in macaque monkeys delays saccadic eye movements when made to visual targets located in the receptive field of the stimulated neurons. This review discusses the following issues. First, the parameters that affect the delay of saccades by microstimulation of V1 are reviewed. Second, the excitability properties of the V1 elements mediating the delay are discussed. Third, the properties that determine the size and shape of the region of visual space affected by stimulation of V1 are described. This region is called a delay field. Fourth, whether the delay effect is mainly due to a disruption of the visual signal transmitted through V1 or whether it is a disturbance of the motor signal transmitted between V1 and the brain stem saccade generator is investigated. Fifth, the properties of delay fields are used to estimate the number of elements activated directly by electrical microstimulation of macaque V1. Sixth, these properties are used to make inferences about the characteristics of visual percepts induced by such stimulation. Seventh, the disruptive effects of V1 stimulation in monkeys and humans are compared. Eighth, a cortical mechanism to account for the disruptive effects of V1 stimulation is proposed. Finally, these effects are related to normal vision.
Tehovnik
Edward J
EJ
Dept. of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Bldg. 46-6041, Cambridge, MA 02139, USA. tehovnik@mit.edu
Slocum
Warren M
WM
D000818:Animals; D001931:Brain Mapping; D023882:Dominance, Ocular; D004558:Electric Stimulation / Q000379:methods; D006801:Humans; D008253:Macaca mulatta; D011930:Reaction Time / Q000502:physiology* / Q000528:radiation effects; D012438:Saccades / Q000502:physiology / Q000528:radiation effects; D014793:Visual Cortex / Q000502:physiology*; D014794:Visual Fields / Q000502:physiology* / Q000528:radiation effects; D014796:Visual Perception / Q000502:physiology* / Q000528:radiation effects