Participant and parent experiences in the parenteral insulin arm of the diabetes prevention trial for type 1 diabetes.
OBJECTIVE
To assess participant and parent experiences in the parenteral insulin arm of the Diabetes Prevention Trial for Type 1 Diabetes (DPT-1).


METHODS
Before trial results were publicized, surveys were completed by 82 intervention participants (the intervention group) (who received annual 4-day insulin infusions and daily insulin injections), 81 closely monitored control subjects (the closely monitored group), and 135 parents of children in the trial.


RESULTS
Survey results suggest that participant perspective (adult, child, parent, and sex), study procedures, and group assignment have important implications when planning clinical trials. Parents rated the trial more favorably but worried about hypoglycemia and diabetes onset. Children had the least favorable reaction to the study. Parents preferred assignment to the intervention group; child/adult participants preferred assignment to the closely monitored group. The intervention group rated the annual 4-day insulin infusions more negatively than all other study procedures. Intervention group participants/parents reported poorer insulin injection adherence over the course of the study. Intervention group participants, parents, and female subjects expressed an interest in additional psychosocial support during the trial. Random assignment was viewed negatively by both study groups. Close observation for diabetes onset was viewed as the most favorable aspect of the study. Behaviors outside of the study protocol to prevent or delay diabetes onset were common and should be monitored in future prevention studies.


CONCLUSIONS
Overall, most participants were positive about the trial, and many expressed optimism about the intervention's potential for success. These results have implications for study design, recruitment, and retention procedures in future prevention trials.
Johnson
Suzanne Bennett
SB
Department of Medical Humanities and Social Sciences, Florida State College of Medicine, Tallahassee, Florida, USA. suzanne.johnson@med.fsu.edu
Baughcum
Amy E
AE
Hood
Korey
K
Rafkin-Mervis
Lisa E
LE
Schatz
Desmond A
DA
D000293:Adolescent; D000328:Adult; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000517:prevention & control* / Q000523:psychology; D005260:Female; D019538:Health Care Surveys; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage*; D007263:Infusions, Parenteral; D007267:Injections; D007328:Insulin / Q000008:administration & dosage*; D008297:Male; D010290:Parents / Q000523:psychology; D010342:Patient Acceptance of Health Care / Q000523:psychology*; D010361:Patients / Q000523:psychology
D007004:Hypoglycemic Agents; D007328:Insulin