Undetectable serum anti-Müllerian hormone levels and occurrence of ongoing pregnancy.
OBJECTIVE
To discuss, on the basis of the experience of two clinical cases and extensive literature review, the significance of extremely low levels of anti-Müllerian hormone (AMH), also known as Müllerian-inhibiting substance, in infertile women.


METHODS
Case report.


METHODS
University-based infertility clinic at a medical center in Switzerland.


METHODS
Two women, 29 and 41 years of age and with a 2- and 4-year history of secondary infertility, respectively.


METHODS
Clinical, radiological, and biological investigation of infertility, including repeated measurements of the serum AMH with serial ELISA assays.


METHODS
Levels of AMH and development of ongoing pregnancy.


RESULTS
Both women had a spontaneous ongoing pregnancy despite undetectable AMH levels.


CONCLUSIONS
Although it is helpful for day-to-day management of infertile patients, the predictive value of AMH for the occurrence of a spontaneous ongoing pregnancy has limits.
Fraisse
Timothée
T
Unité d'Endocrinologie Gynécologique et Médecine de la Reproduction, Hôpitaux Universitaires de Genève, Département de Gynécologie et d'Obstétrique, Geneva, Switzerland. timothee.fraisse@escp-eap.net
Ibecheole
Victoria
V
Streuli
Isabelle
I
Bischof
Paul
P
de Ziegler
Dominique
D
D000328:Adult; D054304:Anti-Mullerian Hormone / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005298:Fertility; D006801:Humans; D007247:Infertility, Female / Q000097:blood* / Q000503:physiopathology; D011237:Predictive Value of Tests; D011247:Pregnancy; D015203:Reproducibility of Results
D015415:Biomarkers; D054304:Anti-Mullerian Hormone