Regulation of excitability by potassium channels.
Neurons express a large number of different voltage-gated potassium (Kv) channels with distinct biophysical and biochemical properties. Possibly, this diversity reflects the need to regulate and fine-tune neuronal excitability at various levels of complexity in space and time. In this context, Kv channels operating in the subthreshold range of action- potential firing are of particular interest. It is likely that these Kv channels play a prominent role in both propagating and integrating dendritic signaling, as well as axonal action-potential firing and propagation.
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Institute for Neural Signal Conduction, Center for Molecular Neurobiology, University Hospital Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg, Germany. morin@zmnh.uni-hamburg.de
D000818:Animals; D019706:Excitatory Postsynaptic Potentials / Q000502:physiology*; D006801:Humans; D015640:Ion Channel Gating / Q000502:physiology*; D009422:Nervous System Diseases / Q000378:metabolism*; D009474:Neurons / Q000502:physiology*; D024642:Potassium Channels, Voltage-Gated / Q000502:physiology*
D024642:Potassium Channels, Voltage-Gated