title: Interleukin-6 levels and HPA axis activation in breast cancer patients with major depressive disorder.
abstract: An association or a casual link has been proposed between the neuroendocrinological and neuroimmunological changes attributed to either depression or cancer. This study investigated whether breast cancer patients with and without major depression exhibit plasma interleukin-6 abnormalities and dexamethasone suppression test results. Four groups, each consisting of 30 women (1--healthy women, 2--patients with major depression, 3--breast cancer patients without major depression, 4--breast cancer patients with major depression), were compared to each other. Psychiatric evaluations were made by structured clinical interview for DSM-IV. Severity of depression was measured with the Hamilton Depression Rating Scale. Plasma levels of interleukin-6 were measured. A dexamethasone suppression test was applied. Breast cancer patients with major depression had markedly higher plasma levels of interleukin-6 than the other group. All breast cancer patients with depression had abnormal dexamethasone suppression test results. These findings suggest a hypothalamo-pituitary-adrenal axis activation and plasma levels of interleukin-6 and plasma interleukin-6 elevation and plasma levels if interleukin-6 and plasma levels of post cortisol concentrations. Evidence for a casual link or association of major depression with immune and endocrinological activation needs to be investigated further.
authors.affiliation: Ankara Oncology Training and Research Hospital, Psychiatry Clinic, Ankara, Turkey. soygur.haldun@isbank.net.tr
authors.forename: Haldun
authors.initials: H
authors.lastname: Soygur
authors.forename: Ozden
authors.initials: O
authors.lastname: Palaoglu
authors.forename: Eyüp Sabri
authors.initials: ES
authors.lastname: Akarsu
authors.forename: Eylem Sahin
authors.initials: ES
authors.lastname: Cankurtaran
authors.forename: Elvan
authors.initials: E
authors.lastname: Ozalp
authors.forename: Levent
authors.initials: L
authors.lastname: Turhan
authors.forename: Ismail Hakki
authors.initials: IH
authors.lastname: Ayhan
mesh_terms: D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D001943:Breast Neoplasms / Q000097:blood* / Q000150:complications / Q000473:pathology*; D003865:Major Depressive Disorder / Q000097:blood* / Q000150:complications / Q000473:pathology*; D003907:Dexamethasone; D005260:Female; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology*; D015850:Interleukin-6 / Q000097:blood*; D008875:Middle Aged; D010913:Pituitary-Adrenal System / Q000503:physiopathology*; D011569:Psychiatric Status Rating Scales / Q000706:statistics & numerical data; D018709:Statistics, Nonparametric
chemical_list: D015850:Interleukin-6; D003907:Dexamethasone