Gastrointestinal stromal tumors involving the prostate: presentation, course, and therapeutic approach.
Gastrointestinal stromal tumors are relatively rare soft-tissue neoplasms arising from the gastrointestinal tract. The clinical presentation of gastrointestinal stromal tumors varies and depends on the tumor size and location. We present 2 patients with a gastrointestinal stromal tumor who presented with genitourinary symptoms and were diagnosed by transrectal ultrasound-guided prostate biopsy. We describe the clinical presentation and diagnostic and therapeutic approach to these cases, highlighting the successful preoperative use of imatinib mesylate (Gleevec) followed by prostatectomy.
Arce-Lara
Carlos
C
Department of Internal Medicine, Division of Hematology/Oncology, Ohio State University, Columbus, Ohio 43210-1280, USA. carlos.arce-lara@osumc.edu
Shah
Manisha H
MH
Jimenez
Rafael E
RE
Patel
Vipul R
VR
Benson
Don M
DM
Clinton
Steven K
SK
Monk
J Paul
JP
D000970:Antineoplastic Agents / Q000627:therapeutic use; D001549:Benzamides; D001707:Biopsy, Needle; D046152:Gastrointestinal Stromal Tumors / Q000175:diagnosis / Q000188:drug therapy / Q000556:secondary*; D006801:Humans; D000068877:Imatinib Mesylate; D008297:Male; D008875:Middle Aged; D009382:Neoplasms, Unknown Primary; D010879:Piperazines / Q000627:therapeutic use; D011471:Prostatic Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000556:secondary*; D011743:Pyrimidines / Q000627:therapeutic use; D016896:Treatment Outcome
D000970:Antineoplastic Agents; D001549:Benzamides; D010879:Piperazines; D011743:Pyrimidines; D000068877:Imatinib Mesylate