Familial cutaneous collagenoma: new affected family with prepubertal onset.
Two siblings presented with clinical and histopathological findings of familial cutaneous collagenoma which is a rare connective tissue nevus, inherited in an autosomal-dominant pattern. A 13-year-old girl had oval-round, soft, painless papules, 5-10 mm in size and a total of 9-10 on her abdomen and flanks. Skin biopsy demonstrated dense, coarse collagen fibers in the dermis and a decrease in elastic fibers. Doppler echocardiography indicated an atrioseptal defect of the secundum type. Her 9-year-old brother was also examined; four lesions were discovered on his back but he was otherwise normal. Our cases comprise the sixth affected family to be reported in the medical published work and all lesions had appeared prepubertally.
Gurel
Mehmet Salih
MS
Dermatology Clinic, Istanbul Education and Research Hospital, Istanbul, Turkey. mehmetgurel@superonline.com
Mulayim
Mehmet Kamil
MK
Ozardali
Ilyas
I
Bitiren
Muharrem
M
D000293:Adolescent; D002648:Child; D003094:Collagen; D004547:Elastic Tissue / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D009372:Neoplasms, Connective Tissue / Q000235:genetics / Q000473:pathology*; D009506:Nevus / Q000235:genetics / Q000473:pathology*; D010375:Pedigree; D012878:Skin Neoplasms / Q000235:genetics / Q000473:pathology*
D003094:Collagen