title: Synthesis of 1H-imidazo[1,2-b]-1,2,4-triazol-6-amines via multicomponent reaction.
abstract: A simple and effective method for the synthesis of bioactive imidazo[1,2,4]triazole analogues has been developed utilizing the MCR technique, which involved the reaction of aminotriazoles, isocyanides and aldehydes. The products were characterized by (1)H, (13)C NMR spectroscopy, MS and elemental analysis. Interestingly, compounds 19d, 21a, 21b and 21h displayed good cytotoxic activities at 10(-4) M concentration in the inhibition of tumor cell growth as evaluated by the MTT method.
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, P.R. China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Huang
authors.forename: Xiu-Qin
authors.initials: XQ
authors.lastname: Hu
authors.forename: Da-Peng
authors.initials: DP
authors.lastname: Shen
authors.forename: Yong-Fei
authors.initials: YF
authors.lastname: Chen
authors.forename: Peng-Fei
authors.initials: PF
authors.lastname: Xu
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000494:pharmacology; D002384:Catalysis; D002478:Cells, Cultured; D004353:Drug Evaluation, Preclinical; D006801:Humans; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D051379:Mice; D008954:Models, Biological; D013211:Staphylococcus aureus / Q000187:drug effects; D013329:Structure-Activity Relationship; D014230:Triazoles / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D007093:Imidazoles; D014230:Triazoles