title: Time course of VCAM-1 and ICAM-1 in CSF in patients with basal ganglia haemorrhage.
abstract: OBJECTIVE
  In a pilot study we found a correlation of the clinical outcome with adhesion molecule (AM) concentrations in ventricular cerebrospinal fluid (CSF) but not in serum in patients with intracerebral haemorrhage. We now determined the time course of AM concentration in CSF and serum after basal ganglia haemorrhage (BGH) in order to further uncover pathogenetic mechanisms.
  
  
  METHODS
  We included 11 patients with acute BGH and ventricular tamponade in which an extraventricular drainage had been applied to treat ventricular ballonade. Paired CSF and serum samples were obtained within 8 h after onset of BGH, as well as on the consecutive days 2, 4, 6, and 8, respectively. The concentrations of soluble ICAM-1 (sICAM-1) and VCAM-1 (sVCAM-1) in CSF and serum were measured by enzyme-linked immunosorbent assay. Moreover, we determined blood volume and perifocal oedema by a semi-automated planimetry technique from initial cranial computed tomography scans.
  
  
  RESULTS
  sICAM-1 and sVCAM-1 levels in CSF were highest within the first hours after onset of BGH, then decreased significantly (P < 0.005 and <0.05, respectively) on day 2 and slightly increased thereafter. Furthermore, BGH volume was significantly correlated with the concentrations of sICAM-1 (r = 0.63, P < 0.05) and sVCAM-1 (r = 0.66, P < 0.05) in ventricular CSF but not in serum.
  
  
  CONCLUSIONS
  Our results might indicate that the local inflammatory reaction is pronounced early after onset of BGH and appears to be restricted to the central nervous system. Moreover, AM concentrations measured early after BGH onset correlated stronger with radiological and clinical data than follow-up measurements.
authors.affiliation: Paracelsus Private Medical University and Salzburger Landesklinken, Christian-Doppler-Klinik, Department of Neurology, Ignaz-Harrer-Strasse Salzburg, Austria.
authors.forename: J
authors.initials: J
authors.lastname: Kraus
authors.forename: T
authors.initials: T
authors.lastname: Gerriets
authors.forename: S
authors.initials: S
authors.lastname: Leis
authors.forename: E
authors.initials: E
authors.lastname: Stolz
authors.forename: P
authors.initials: P
authors.lastname: Oschmann
authors.forename: J G
authors.initials: JG
authors.lastname: Heckmann
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D020145:Basal Ganglia Hemorrhage / Q000150:complications / Q000378:metabolism* / Q000503:physiopathology; D001810:Blood Volume / Q000502:physiology; D001929:Brain Edema / Q000209:etiology*; D002552:Cerebral Ventricles / Q000378:metabolism / Q000503:physiopathology; D002560:Cerebrovascular Circulation / Q000502:physiology; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood* / Q000134:cerebrospinal fluid*; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood* / Q000134:cerebrospinal fluid*
chemical_list: D019010:Vascular Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1