Pathogenesis of Parkinson's disease: oxidative stress, environmental impact factors and inflammatory processes.
Current hypothesis of neuronal degeneration in Parkinson's disease (PD) have been proposed, including formation of free radicals and oxidative stress, mitochondrial dysfunction, excitotoxicity, trophic factor deficiency, inflammatory processes, genetic factors, environmental impact factors, toxic action of nitric oxide, apoptosis, and so on. This review mainly discussed oxidative stress, environmental impact factors, and inflammatory processes in PD.
Yuan
Hong
H
Department of Integrated Traditional Chinese and Western Medicine, the General Hospital of Chinese People's Armed Police Forces, Beijing 100039, China. hongyuan6@yahoo.com
Zheng
Jing-Chen
JC
Liu
Ping
P
Zhang
Shao-Feng
SF
Xu
Jian-Yang
JY
Bai
Li-Min
LM
D000818:Animals; D004785:Environmental Pollutants / Q000009:adverse effects*; D006801:Humans; D007249:Inflammation / Q000276:immunology; D018384:Oxidative Stress / Q000276:immunology*; D010300:Parkinson Disease / Q000276:immunology* / Q000503:physiopathology
D004785:Environmental Pollutants