title: Improving the compaction properties of roller compacted calcium carbonate.
abstract: The effects of roller compaction process parameters, morphological forms of calcium carbonate and particle size of sorbitol on flow, compaction and compression properties were investigated. The morphology of the calcium carbonate and the sorbitol particle size were more influential on the compaction properties than the settings of the roller compactor. The roller compaction process was demonstrated to be robust and stable in regard to flowability and compactibility. The flowability of the granules was improved adequately to facilitate compression in a production scale rotary tablet press. By adding sorbitol to the calcium carbonate, the compressibility - characterized by the Walker coefficient W(ID) - and the compactibility C(P) were improved considerably. A correlation between the consolidation characteristics was demonstrated. Compactibility data from the compaction simulator correlated with the tablet press for two of the calcium carbonates, the cubic form and the ground quality.
authors.affiliation: Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, DK-2100 Universitetsparken 2, Copenhagen, Denmark.
authors.forename: C
authors.initials: C
authors.lastname: Bacher
authors.forename: P M
authors.initials: PM
authors.lastname: Olsen
authors.forename: P
authors.initials: P
authors.lastname: Bertelsen
authors.forename: J
authors.initials: J
authors.lastname: Kristensen
authors.forename: J M
authors.initials: JM
authors.lastname: Sonnergaard
mesh_terms: D000465:Algorithms; D002119:Calcium Carbonate / Q000737:chemistry*; D004339:Drug Compounding / Q000295:instrumentation*; D004345:Drug Industry / Q000295:instrumentation; D005079:Excipients; D008855:Microscopy, Electron, Scanning; D010316:Particle Size; D010592:Pharmaceutic Aids / Q000737:chemistry; D011208:Powders; D011312:Pressure; D013012:Sorbitol / Q000737:chemistry; D013229:Stearic Acids; D013607:Tablets
chemical_list: D005079:Excipients; D010592:Pharmaceutic Aids; D011208:Powders; D013229:Stearic Acids; D013607:Tablets; C031183:stearic acid; D013012:Sorbitol; D002119:Calcium Carbonate