Flavors in gene-environment interactions.
In this issue, Noel Weiss (Epidemiology. 2007;18:429-430) presents the argument that gene-environment interaction should be approached through analysis of genetic effects within strata of environmental exposure, rather than the analysis of environmental effects within strata of genetic variants. Both approaches depend on a pair of 2-by-2 tables. I suggest that, at least for an initial look, the 2-by-4 table has advantages.
Botto
Lorenzo D
LD
From the Division of Medical Genetics, Department of Pediatrics, University of Utah, Salt Lake City, Utah.
D003627:Data Interpretation, Statistical; D004194:Disease / Q000209:etiology; D004781:Environmental Exposure / Q000009:adverse effects*; D020022:Genetic Predisposition to Disease; D006801:Humans