title: Future research into abnormal uterine bleeding.
abstract: Abnormal uterine bleeding in terms of menstrual disorders and postmenopausal bleeding are common clinical problems in both primary and secondary care. Advances in diagnostic and therapeutic technologies have offered opportunities to improve the outcomes of women suffering with these complaints. Future research should concentrate on a robust approach to the assessment of these health technologies, including the use of outcome assessments of importance to patients such as effects on health-related quality of life and taking account of patient preferences. In addition, economic evaluations need to be conducted alongside clinical research to facilitate a rational basis on which to allocate resources and upon which to base clinical decisions. Specific areas highlighted for research in this review include the role of diagnostic technologies incorporating the clinical context within which diagnostic work-up takes place. The clinical application of progesterone antagonists and selective progesterone receptor modulators is a developing area with potential for the treatment of menorrhagia. The place of minimally invasive therapies for the treatment of menstrual dysfunction and fibroid-associated menorrhagia needs more examination, as does the place of outpatient 'ambulatory' settings to provide convenient, effective 'see and treat' targeted services in both primary and secondary care.
authors.affiliation: Department of Obstetrics & Gynaecology, Birmingham Women's Hospital, Birmingham, UK.
authors.forename: Nadia C
authors.initials: NC
authors.lastname: Samuel
authors.forename: T Justin
authors.initials: TJ
authors.lastname: Clark
mesh_terms: D035843:Biomedical Research / Q000379:methods / Q000639:trends*; D001778:Blood Coagulation Disorders / Q000150:complications / Q000175:diagnosis; D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000628:therapy; D008595:Menorrhagia / Q000209:etiology / Q000628:therapy; D012107:Research Design; D012196:Review Literature as Topic; D013673:Technology Assessment, Biomedical / Q000592:standards; D014592:Uterine Hemorrhage / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000628:therapy*; D014594:Uterine Neoplasms / Q000628:therapy