title: Genetic structure of the nadA and nadB antivirulence loci in Shigella spp.
abstract: Comparison of nadA and nadB in 14 Shigella strains and enteroinvasive Escherichia coli versus E. coli showed that at least one locus is altered in all strains. These observations explain the characteristic nicotinic acid auxotrophy of Shigella organisms and are consistent with the previously identified antivirulence nature of these genes for these pathogens.
authors.affiliation: Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, F. Edward Hébert School of Medicine, 4301 Jones Bridge Road, Bethesda, MD 20814-4799, USA.
authors.forename: Anne-Laure
authors.initials: AL
authors.lastname: Prunier
authors.forename: Raymond
authors.initials: R
authors.lastname: Schuch
authors.forename: Reinaldo E
authors.initials: RE
authors.lastname: Fernández
authors.forename: Anthony T
authors.initials: AT
authors.lastname: Maurelli
mesh_terms: D000594:Amino Acid Oxidoreductases / Q000235:genetics* / Q000378:metabolism*; D000595:Amino Acid Sequence; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D004926:Escherichia coli / Q000235:genetics / Q000502:physiology; D029968:Escherichia coli Proteins; D008969:Molecular Sequence Data; D009097:Multienzyme Complexes / Q000235:genetics*; D017386:Sequence Homology, Amino Acid; D012763:Shigella flexneri / Q000235:genetics* / Q000472:pathogenicity* / Q000502:physiology; D014774:Virulence / Q000235:genetics
chemical_list: D001426:Bacterial Proteins; D029968:Escherichia coli Proteins; D009097:Multienzyme Complexes; C022512:quinolinic acid synthetase; D000594:Amino Acid Oxidoreductases; C031955:L-aspartate oxidase, E coli