title: Expression of estrogen receptor-alpha protein in the rat digestive tract.
abstract: The current study evaluates the expression of estrogen receptor-alpha (ER-alpha) protein in the digestive tract and other organs using immunohistochemistry in male and female intact rats. As a result, the expression of ER-alpha protein was intensively immunoreactive in the nuclei of squamous epithelium of the forestomach connected to the limiting ridge and the anus connected to the anorectal junction. Rat ER-alpha mRNA signals were also detected in the epithelium of the limiting ridge using in situ hybridization. The incidence of ER-alpha protein in the limiting ridge decreased with age in both males and females. The incidence of ER-alpha protein in the anorectal junction strongly decreased with age in males, although the incidence did not decrease with age in females. In conclusion, it was suggested that estrogen may be involved in the proliferation and differentiation of these cells in the limiting ridge of the stomach and anorectal junction of rats.
authors.affiliation: The Department of Tumor Pathology, Field of Oncology, Hepato-Biliary-Pancreatic Surgery, Kagoshima University, Graduate School of Medical and Dental Sciences, Kagoshima, 890-8544, Japan.
authors.forename: Kentaro
authors.initials: K
authors.lastname: Gejima
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Kawaguchi
authors.forename: Masakazu
authors.initials: M
authors.lastname: Souda
authors.forename: Hideo
authors.initials: H
authors.lastname: Kawashima
authors.forename: Teruo
authors.initials: T
authors.lastname: Komokata
authors.forename: Nobuo
authors.initials: N
authors.lastname: Hamada
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Umekita
authors.forename: Ryuzo
authors.initials: R
authors.lastname: Sakata
authors.forename: Hiroki
authors.initials: H
authors.lastname: Yoshida
mesh_terms: D000367:Age Factors; D001003:Anal Canal / Q000166:cytology / Q000378:metabolism; D000818:Animals; D002299:Cardia / Q000166:cytology / Q000378:metabolism; D002467:Cell Nucleus / Q000378:metabolism; D004847:Epithelial Cells / Q000378:metabolism; D005260:Female; D041981:Gastrointestinal Tract / Q000378:metabolism*; D005786:Gene Expression Regulation; D007124:Immunoenzyme Techniques; D017403:In Situ Hybridization; D008297:Male; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D011960:Receptors, Estrogen / Q000235:genetics / Q000378:metabolism*; D046888:Tissue Array Analysis; D000097983:ERRalpha Estrogen-Related Receptor
chemical_list: D012333:RNA, Messenger; D011960:Receptors, Estrogen; D000097983:ERRalpha Estrogen-Related Receptor