title: [Cryosurgical ablation for aged patients with severe benign prostate hyperplasia: a report of 21 cases].
abstract: OBJECTIVE
  To study the clinical effect of cryosurgical ablation for aged patients with severe benign prostate hyperplasia.
  
  
  METHODS
  Twenty-one 72-91-year-old patients with severe benign prostate hyperplasia accompanied with cardiopulmonary dysfunction were treated by the ENDOCARE cryo-care surgery system with cryo-probes guided by type B ultrasound. Observations were made of the post-operation prostate biopsy and ultrasonogram as well as the changes of the urinary flow rate (UFR) and prostate-specific antigen (PSA).
  
  
  RESULTS
  Degeneration and necrosis of the prostate tissues were found after the operation, with the signs of being completely melted. The mean UFRs before and after the operation were (3.8 +/- 2.1) ml/s and (17.0 +/- 5.8) ml/s, respectively (P < 0.01). Compared with the pre-operation level of PSA ([3.7 +/- 2.1] microg/L), the 1-week post-operation level was significantly higher ([22.6 +/- 13.1] microg/L) (P < 0.01), while the 4-week post-operation level significantly lower ([1.7 +/- 1.4] microg/L) (P < 0.05).
  
  
  CONCLUSIONS
  Cryosurgical ablation, with satisfactory short-term curative effect, is a desirable option for the treatment of aged patients with severe benign prostate hyperplasia.
authors.affiliation: Department of Urology, 81st Hospital of PLA, Nanjing, Jiangsu 210002, China. wangax@mail.china.com
authors.forename: An-xi
authors.initials: AX
authors.lastname: Wang
authors.forename: Dong
authors.initials: D
authors.lastname: Wang
authors.forename: Wei
authors.initials: W
authors.lastname: Tong
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003452:Cryosurgery; D006801:Humans; D053685:Laser Therapy; D008297:Male; D017430:Prostate-Specific Antigen / Q000097:blood; D011470:Prostatic Hyperplasia / Q000097:blood / Q000601:surgery*; D016896:Treatment Outcome
chemical_list: D017430:Prostate-Specific Antigen