title: The effects of increased ischemic times on adipose tissue: a histopathologic study using the epigastric flap model in rats.
abstract: Little study has investigated the ischemic injury of mature adipocytes. This study researched the effects of different ischemic times on fat histology the 7th postischemic day in a rat epigastric flap model. For this study, 24 rats were randomly divided into four groups subjected, respectively, to 1, 2, 3, and 4 h of ischemia. The most severe inflammation and fat necrosis scores were seen in groups 3 and 4 (p < 0.05). According to the findings of this study, it is possible to say that fat tissue undergoes a gross necrosis after 3 or more hours of ischemia. After that ischemic time, the necrotic volume of fat tissue subjected to ischemic insult does not increase with increased ischemic time.
authors.affiliation: Department of Plastic Surgery, Sutcuimam University School of Medicine, 46100 Kahramanmaras, Turkey. kenancoban@ksu.edu.tr
authors.forename: Yusuf K
authors.initials: YK
authors.lastname: Coban
authors.forename: Harun
authors.initials: H
authors.lastname: Ciralik
mesh_terms: D000273:Adipose Tissue / Q000098:blood supply* / Q000473:pathology*; D000818:Animals; D004195:Disease Models, Animal; D005205:Fascia / Q000098:blood supply / Q000473:pathology; D005218:Fat Necrosis / Q000473:pathology*; D007511:Ischemia / Q000473:pathology*; D051381:Rats; D011913:Rats, Inbred BB; D013524:Surgical Flaps