title: Imaging tumor vascular heterogeneity and angiogenesis using dynamic contrast-enhanced magnetic resonance imaging.
abstract: This article reviews the application of dynamic contrast-enhanced magnetic resonance imaging in both clinical studies and early-phase trials of angiogenesis inhibitors. Emphasis is placed on how variation in image acquisition and analysis affects the meaning and use of derived variables. We then review the potential for future developments, with particular reference to the application of dynamic contrast-enhanced magnetic resonance imaging to evaluate the heterogeneity of tumor tissues.
authors.affiliation: Imaging Science and Biomedical Engineering, University of Manchester, Manchester, United Kingdom.
authors.forename: Alan
authors.initials: A
authors.lastname: Jackson
authors.forename: James P B
authors.initials: JP
authors.lastname: O'Connor
authors.forename: Geoff J M
authors.initials: GJ
authors.lastname: Parker
authors.forename: Gordon C
authors.initials: GC
authors.lastname: Jayson
mesh_terms: D020533:Angiogenesis Inhibitors / Q000627:therapeutic use; D000818:Animals; D002986:Clinical Trials as Topic; D006801:Humans; D007089:Image Enhancement; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D009369:Neoplasms / Q000098:blood supply* / Q000000981:diagnostic imaging / Q000188:drug therapy; D009389:Neovascularization, Pathologic; D011859:Radiography
chemical_list: D020533:Angiogenesis Inhibitors