title: Insulin-like growth factors-I and -II and insulin-like growth factor binding protein-1 during normal pregnancy: pattern of secretion and correlation with other placental hormones.
abstract: OBJECTIVE
  To describe pattern of secretion of insulin-like growth factor (IGF)-I, IGF-II, IGF binding protein (IGFBP)-1 and their correlation with each other and major placental hormones during normal pregnancy.
  
  
  METHODS
  Longitudinal study.
  
  
  METHODS
  Academic Institutions and a Tertiary Care Maternity Hospital.
  
  
  METHODS
  Healthy women with singleton uncomplicated pregnancies (N = 35).
  
  
  METHODS
  Serum levels of IGF-I, IGF-II, IGFBP-1, chorionic gonadotrophin (HCG), placental lactogen (HPL), prolactin, oestradiol and progesterone were studied thrice during the antenatal period and within 24 h of delivery.
  
  
  RESULTS
  IGF-I, IGFBP-1, HPL, prolactin, oestradiol and progesterone increased and HCG decreased significantly with advancing gestation (Repeated measures ANOVA: P < 0.01 to 0.0001). IGF-II levels were not significantly affected by period of gestation. Significant negative correlations (multiple regression analysis) were seen between IGFBP-1 and prolactin at 28 +/- 2 (P = 0.0226) and 36 +/- 2 (P = 0.0417) weeks of amenorrhoea (WOA) and between oestradiol and IGF-II at 36 +/- 2 WOA (P = 0.037). Prolactin and IGF-I at 14 +/- 2 WOA (P = 0.0225) and progesterone and IGFBP-1 at 28 +/- 2 WOA (P = 0.0216) correlated positively.
  
  
  CONCLUSIONS
  Maternal IGF-I and IGFBP-1 but not IGF-II significantly increase as pregnancy advances. Components of the IGF system regulate or are affected by some of the placental hormones and the effects vary with the period of gestation.
authors.affiliation: Department of Physiology, Faculty of Medicine, University of Colombo. khtennekoon@med.cmb.ac.lk
authors.forename: K H
authors.initials: KH
authors.lastname: Tennekoon
authors.forename: A N
authors.initials: AN
authors.lastname: Pathmaperuma
authors.forename: L
authors.initials: L
authors.lastname: Senanayake
authors.forename: E H
authors.initials: EH
authors.lastname: Karunanayake
mesh_terms: D000328:Adult; D006063:Chorionic Gonadotropin / Q000097:blood / Q000378:metabolism; D004958:Estradiol / Q000097:blood / Q000378:metabolism; D005260:Female; D006801:Humans; D018970:Insulin-Like Growth Factor Binding Protein 1 / Q000097:blood / Q000378:metabolism*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D007335:Insulin-Like Growth Factor II / Q000378:metabolism*; D010920:Placenta / Q000378:metabolism*; D010928:Placental Lactogen / Q000097:blood / Q000378:metabolism; D011247:Pregnancy / Q000378:metabolism*; D011374:Progesterone / Q000378:metabolism; D011388:Prolactin / Q000097:blood / Q000378:metabolism
chemical_list: D006063:Chorionic Gonadotropin; D018970:Insulin-Like Growth Factor Binding Protein 1; D011374:Progesterone; D004958:Estradiol; D007334:Insulin-Like Growth Factor I; D007335:Insulin-Like Growth Factor II; D011388:Prolactin; D010928:Placental Lactogen