title: Synthesis of Schiff bases of naphtha[1,2-d]thiazol-2-amine and metal complexes of 2-(2'-hydroxy)benzylideneaminonaphthothiazole as potential antimicrobial agents.
abstract: OBJECTIVE
  A series of 2-benzylideneaminonaphthothiazoles were designed and synthesized incorporating the lipophilic naphthalene ring to render them more capable of penetrating various biomembranes.
  
  
  METHODS
  Schiff bases were synthesized by the reaction of naphtha[1,2-d]thiazol-2-amine with various substituted aromatic aldehydes. 2-(2'-Hydroxy)benzylideneaminonaphthothiazole was converted to its Co(II), Ni(II) and Cu(II) metal complexes upon treatment with metal salts in ethanol. All the compounds were evaluated for their antibacterial activities by paper disc diffusion method with Gram positive Staphylococcus aureus and Staphylococcus epidermidis and Gram negative Escherichia coli and Pseudomonas aeruginosa bacteria. The minimum inhibitory concentrations of all the Schiff bases and metal complexes were determined by agar streak dilution method.
  
  
  RESULTS
  All the compounds moderately inhibited the growth of Gram positive and Gram negative bacteria. In the present study among all Schiff bases 2-(2'-hydroxy)benzylideneaminonaphthothiazole showed maximum inhibitory activity and among metal complexes Cu(II) metal complex was found to be most potent.
  
  
  CONCLUSIONS
  The results obtained validate the hypothesis that Schiff bases having substitution with halogens, hydroxyl group and nitro group at phenyl ring are required for the antibacterial activity while methoxy group at different positions in the aromatic ring has minimal role in the inhibitory activity. The results also indicated that the metal complexes are better antibacterial agents as compared to the Schiff bases.
authors.affiliation: Department of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra, Haryana, India. faizulazam@gmail.com
authors.forename: Faizul
authors.initials: F
authors.lastname: Azam
authors.forename: Satendra
authors.initials: S
authors.lastname: Singh
authors.forename: Sukhbir Lal
authors.initials: SL
authors.lastname: Khokhra
authors.forename: Om
authors.initials: O
authors.lastname: Prakash
mesh_terms: D000588:Amines / Q000138:chemical synthesis / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D003035:Cobalt; D003300:Copper; D009532:Nickel; D012545:Schiff Bases; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000138:chemical synthesis / Q000494:pharmacology
chemical_list: D000588:Amines; D000900:Anti-Bacterial Agents; D012545:Schiff Bases; D013844:Thiazoles; D003035:Cobalt; D003300:Copper; D009532:Nickel