title: Familial ankyloglossia (tongue-tie).
abstract: Ankyloglossia (tongue-tie) is a congenital anomaly with a prevalence of 4-5% and characterized by an abnormally short lingual frenulum. For unknown reasons the abnormality seems to be more common in males. The pathogenesis of ankyloglossia is not known. The author reports a family with isolated ankyloglossia inherited as an autosomal dominant trait. The identification of the defective gene(s) causing ankyloglossia might reveal novel information on the craniofacial embryogenesis and its disorders.
authors.affiliation: Department of Otorhinolaryngology, Kymenlaakso Central Hospital, Kotkantie 41, 48210 Kotka, Finland. tuomas.klockars@fimnet.fi
authors.forename: Tuomas
authors.initials: T
authors.lastname: Klockars
mesh_terms: D006801:Humans; D008035:Lingual Frenum / Q000002:abnormalities* / Q000601:surgery*; D010375:Pedigree; D014060:Tongue Diseases / Q000235:genetics*