title: Nutrient and food intake in relation to serum leptin concentration among young Japanese women.
abstract: OBJECTIVE
  Little is known about the relation of modifiable dietary factors to circulating leptin concentrations, particularly in young adults and non-Western populations. We examined cross-sectional associations between nutrient and food intake and serum leptin concentration in young Japanese women.
  
  
  METHODS
  Subjects were 424 female Japanese dietetic students 18-22 y of age. Intake of macronutrients (protein, total fat; saturated, monounsaturated, and polyunsaturated fatty acids; and carbohydrate), dietary fiber, and 12 food groups was assessed with a validated, self-administered, comprehensive, diet history questionnaire. Fasting blood samples were collected, and serum leptin concentrations were measured by radioimmunoassay.
  
  
  RESULTS
  For nutrients, only dietary fiber was a significant determinant of serum leptin concentration. Increasing dietary fiber intake was associated with lower serum leptin concentration independent of potential confounding factors, including body mass index (mean serum leptin concentrations in the lowest and highest quintiles of dietary fiber intake were 8.6 and 7.5 ng/mL, respectively; P for trend = 0.026). Vegetables and pulses were the only foods significantly associated with serum leptin concentration, with higher intakes independently associated with lower concentrations (mean serum leptin concentrations in the lowest and highest quintiles of intake were 8.1 and 7.0 ng/mL, P for trend = 0.007, for vegetables and 8.8 and 7.6 ng/mL, P for trend = 0.019, for pulses, respectively).
  
  
  CONCLUSIONS
  Intake of dietary fiber, vegetables, and pulses showed an independent inverse association with serum leptin concentration in a group of young Japanese women.
authors.affiliation: Nutritional Epidemiology Program, National Institute of Health and Nutrition, Tokyo, Japan.
authors.forename: Kentaro
authors.initials: K
authors.lastname: Murakami
authors.forename: Satoshi
authors.initials: S
authors.lastname: Sasaki
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Takahashi
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Uenishi
authors.forename: Mitsuyo
authors.initials: M
authors.lastname: Yamasaki
authors.forename: Hitomi
authors.initials: H
authors.lastname: Hayabuchi
authors.forename: Toshinao
authors.initials: T
authors.lastname: Goda
authors.forename: Jun
authors.initials: J
authors.lastname: Oka
authors.forename: Keiko
authors.initials: K
authors.lastname: Baba
authors.forename: Kazuko
authors.initials: K
authors.lastname: Ohki
authors.forename: Reiko
authors.initials: R
authors.lastname: Watanabe
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Sugiyama
mesh_terms: D000293:Adolescent; D000328:Adult; D044466:Asian People; D003430:Cross-Sectional Studies; D004032:Diet; D004040:Dietary Carbohydrates / Q000008:administration & dosage; D004041:Dietary Fats / Q000008:administration & dosage; D004043:Dietary Fiber / Q000008:administration & dosage*; D004044:Dietary Proteins / Q000008:administration & dosage; D002149:Energy Intake; D007887:Fabaceae; D005215:Fasting / Q000097:blood; D005247:Feeding Behavior; D005260:Female; D006801:Humans; D007564:Japan; D020738:Leptin / Q000097:blood*; D011863:Radioimmunoassay; D011795:Surveys and Questionnaires; D014675:Vegetables
chemical_list: D004040:Dietary Carbohydrates; D004041:Dietary Fats; D004043:Dietary Fiber; D004044:Dietary Proteins; D020738:Leptin