Pylorus-preserving pancreatoduodenectomy: preoperative pancreatic function and outcome.
OBJECTIVE
To investigate the effects of preoperative pancreatic function on gastric emptying, body weight, and quality of life after pylorus-preserving pancreatoduodenectomy.


METHODS
Thirty-one patients who underwent pylorus-preserving pancreatoduodenectomy were divided into 2 groups according to preoperative pancreatic exocrine and endocrine function (normal vs. abnormal). Gastric emptying, body weight, and quality of life were evaluated before surgery, 1-2 months after surgery (short-term), and 6-12 months after surgery (long-term).


RESULTS
Short-term body weight was significantly decreased in comparison to preoperative body weight regardless of preoperative exocrine and endocrine pancreatic function. Body weight returned to the preoperative level by 12 months after surgery in patients with normal preoperative pancreatic function but not in patients with abnormal pancreatic function. In both groups, gastric emptying was delayed at 1-2 months after surgery and then returned to the preoperative value by 12 months. Short-term quality of life did not differ from preoperative quality of life in either group, but long-term quality of life improved to beyond the preoperative level in both groups.


CONCLUSIONS
Preoperative pancreatic function appears to significantly influence long-term body weight after pylorus-preserving pancreatoduodenectomy.
Ohuchida
Jiro
J
Department of Surgery 1, Miyazaki University School of Medicine, Miyazaki, Japan.
Chijiiwa
Kazuo
K
Ohtsuka
Takao
T
Konomi
Hiroyuki
H
Tanaka
Masao
M
D000368:Aged; D000369:Aged, 80 and over; D001835:Body Weight; D004066:Digestive System Diseases / Q000601:surgery*; D005260:Female; D005746:Gastric Emptying; D006801:Humans; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000502:physiology*; D046790:Pancreas, Exocrine / Q000502:physiology; D016577:Pancreaticoduodenectomy / Q000009:adverse effects* / Q000379:methods*; D011708:Pylorus / Q000601:surgery*; D011788:Quality of Life; D016896:Treatment Outcome