GSTM1 and GSTT1 polymorphisms and the risk of prostate cancer in a Caribbean population of African descent.
OBJECTIVE
To investigate whether the glutathione S-transferase polymorphisms GSTM1 and/or GSTT1 contribute to prostate cancer risk in a Caribbean population of African descent in Guadeloupe.


METHODS
We performed a hospital-based case-control study with 134 prostate cancer patients and 134 cancer-free, age-matched control subjects. Epidemiologic data were collected using a standard questionnaire. Logistic regression was used to estimate odds ratios (ORs) and compute confidence intervals (CIs). Genotypes were determined by multiplex polymerase chain reaction.


RESULTS
The frequency of the GSTM1-positive genotype was 81% in patients and 73% in control subjects, with an adjusted OR of 1.4 (95% CI 0.7 to 2.5). The frequency of the GSTT1-positive genotype was 78% in patients and 63% in control subjects, with an adjusted OR of 2.6 (95% CI 1.4 to 4.9).


CONCLUSIONS
A functional GSTT1 polymorphism may be associated with prostate cancer susceptibility in a Caribbean population of African descent.
Mallick
Stéphane
S
Department of Urology, University Hospital, Pointe à Pitre, Guadeloupe.
Romana
Marc
M
Blanchet
Pascal
P
Multigner
Luc
L
D001741:Black or African American; D000368:Aged; D017691:Caribbean Region / Q000453:epidemiology / Q000208:ethnology; D016022:Case-Control Studies; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011471:Prostatic Neoplasms / Q000453:epidemiology / Q000235:genetics*; D012307:Risk Factors
D005982:Glutathione Transferase; C413545:glutathione S-transferase T1