Prediction of multi-locus inbreeding coefficients and relation to linkage disequilibrium in random mating populations.
An algorithm to predict the level of identity by descent simultaneously at multiple loci is presented, which can in principle be extended to any number of loci. The model assumes a random mating population, with random association of haplotypes. The relationship is shown between coefficients of multi-locus identity or non-identity by descent and moments of multi-locus linkage disequilibrium. Thus, these moments can be computed from the multilocus identity or, using algorithms derived previously to predict the disequilibria moments, vice-versa. The results can be applied to predict multi-locus identity in, for example, gene mapping.
Hill
William G
WG
Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, West Mains Road, Edinburgh, EH9 3JT, UK. w.g.hill@ed.ac.uk
Weir
Bruce S
BS
D000465:Algorithms; D003241:Consanguinity; D005544:Forecasting; D008040:Genetic Linkage; D005828:Genetics, Population; D006801:Humans; D011157:Population Dynamics