title: Generalised sensory system abnormalities in amyotrophic lateral sclerosis: a European multicentre study.
abstract: BACKGROUND
  Amyotrophic lateral sclerosis (ALS) is defined as a disease of the motor neurones, although several studies indicate involvement of the sensory nervous system.
  
  
  OBJECTIVE
  To evaluate the sensory nerve conduction studies (NCS) in 88 patients with ALS as part of a European multicentre study.
  
  
  METHODS
  Seven European clinical neurophysiologists examined consecutive series of ALS patients. The examinations were peer reviewed, and the diagnosis of ALS was confirmed clinically.
  
  
  RESULTS
  20 (22.7%) patients with ALS had sensory NCS abnormalities in at least one nerve. Of those, 11 (12.5% of all patients) obtained an additional peer review diagnosis of electrophysiological polyneuropathy. There was no difference between the subgroups of patients with normal versus abnormal sensory NCS findings with respect to age, duration and region of onset.
  
  
  CONCLUSIONS
  The findings support previous reports of sensory involvement in ALS, and raise the question of whether patients with ALS with sensory nerve abnormalities represent a variant of ALS. ALS associated with generalised sensory system abnormalities may be consistent with degeneration of motor neurones and dorsal root ganglion cells.
authors.affiliation: Department of Clinical Neurophysiology, Aarhus University Hospital, Nørrebrogade 44, 8000 Arhus C, Denmark.
authors.forename: K
authors.initials: K
authors.lastname: Pugdahl
authors.forename: A
authors.initials: A
authors.lastname: Fuglsang-Frederiksen
authors.forename: M
authors.initials: M
authors.lastname: de Carvalho
authors.forename: B
authors.initials: B
authors.lastname: Johnsen
authors.forename: P R W
authors.initials: PR
authors.lastname: Fawcett
authors.forename: A
authors.initials: A
authors.lastname: Labarre-Vila
authors.forename: R
authors.initials: R
authors.lastname: Liguori
authors.forename: W A
authors.initials: WA
authors.lastname: Nix
authors.forename: I S
authors.initials: IS
authors.lastname: Schofield
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000690:Amyotrophic Lateral Sclerosis / Q000503:physiopathology*; D004594:Electrophysiology; D005060:Europe / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009431:Neural Conduction; D009475:Neurons, Afferent / Q000502:physiology*; D012678:Sensation Disorders / Q000453:epidemiology*