title: [Study on expression of matrix metalloproteinase-2 and matrix metalloproteinase-9 in brain tissue adjacent to hemorrhage after brain hemorrhage in human].
abstract: OBJECTIVE
  To investigate the expression and significance of matrix metalloproteinase-2 (MMP-2) and MMP-9 in peri-hematoma brain tissues after acute brain hemorrhage in human.
  
  
  METHODS
  Forty-two patients with acute brain hemorrhage received surgery, the brain tissues adjacent to hemorrhagic site were obtained during surgery, and positive expressions of MMP-2 and MMP-9 were determined with immunohistochemical staining. Brain tissues from 30 patients with cerebral trauma were obtained to serve as controls.
  
  
  RESULTS
  The positive expressions of MMP-2 and MMP-9 in focal brain tissues were significantly elevated in early acute brain hemorrhage. Compared with 28 and 27 cases with MMP-2 and MMP-9 positive expression respectively in control group, there were 39 and 37 cases with MMP-2 and MMP-9 positive expression respectively in acute brain hemorrhage group. There were no significant differences between two groups (both P>0.05).
  
  
  CONCLUSIONS
  MMP-2 and MMP-9 might contribute to brain edema formation in the acute intra-cerebral hemorrhage of human.
authors.affiliation: Taizhou Hospital, Wenzhou Medical College, Linhai 317000, Zhejiang, China.
authors.forename: Shao-fa
authors.initials: SF
authors.lastname: Ke
authors.forename: Xiao-ping
authors.initials: XP
authors.lastname: Jin
authors.forename: Ke-hao
authors.initials: KH
authors.lastname: Zhang
authors.forename: Jun-xing
authors.initials: JX
authors.lastname: Wang
authors.forename: Xiao-ming
authors.initials: XM
authors.lastname: Hu
authors.forename: Dan-hong
authors.initials: DH
authors.lastname: Zhang
authors.forename: Qiu-yue
authors.initials: QY
authors.lastname: Chen
authors.forename: Yuan-lin
authors.initials: YL
authors.lastname: Zhou
mesh_terms: D000328:Adult; D000368:Aged; D001921:Brain / Q000201:enzymology*; D002543:Cerebral Hemorrhage / Q000201:enzymology*; D005260:Female; D006801:Humans; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000378:metabolism*; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism*; D008875:Middle Aged
chemical_list: C522361:MMP2 protein, human; D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9