The immune response during a Strongyloides ratti infection of rats.
A range of immune parameters was measured during a primary infection of Strongyloides ratti in its natural rat host. The immune parameters measured were interleukin-4 (IL-4) and interferon-gamma from both the spleen and mesenteric lymph node (MLN) cells; parasite-specific immunoglobulin G(1)(IgG(1)), IgG(2a) and IgG(2b) in serum and in intestinal tissue; parasite-specific IgG and total IgE in serum; parasite-specific and total IgA in intestinal tissue and rat mast cell protease II in intestinal tissue. Parasite-specific IgG(1), IgG(2a) and total IgE in serum and parasite-specific IgA and rat mast cell protease II in intestinal tissue all occurred at significantly greater concentrations in infected animals, compared with non-infected animals. Similarly, the production of IL-4 by MLN cells stimulated with parasitic female antigen or concanavalin A occurred at significantly greater concentrations in infected animals, compared with non-infected animals. In all, this suggests that there is a T-helper 2-type immune response during a primary S. ratti infection. These data also show the temporal changes in these components of the host immune response during a primary S. ratti infection.
Wilkes
C P
CP
School of Biological Sciences, University of Bristol, Bristol, UK.
Bleay
C
C
Paterson
S
S
Viney
M E
ME
D000818:Animals; D000909:Antibodies, Helminth / Q000032:analysis / Q000097:blood; D005260:Female; D007113:Immunity, Innate; D007073:Immunoglobulin E / Q000032:analysis / Q000097:blood; D007074:Immunoglobulin G / Q000032:analysis / Q000097:blood; D007371:Interferon-gamma / Q000096:biosynthesis; D015847:Interleukin-4 / Q000096:biosynthesis; D051381:Rats; D017208:Rats, Wistar; D017170:Strongyloides ratti / Q000276:immunology* / Q000472:pathogenicity; D013322:Strongyloidiasis / Q000276:immunology* / Q000469:parasitology; D018418:Th2 Cells / Q000276:immunology*
D000909:Antibodies, Helminth; D007074:Immunoglobulin G; D015847:Interleukin-4; D007073:Immunoglobulin E; D007371:Interferon-gamma