title: The effects of acute pretreatment with high-dose memantine on the cardiovascular and behavioral effects of cocaine in humans.
abstract: This study examined the acute effects of pretreatment with high-dose memantine, an N-methyl-D-aspartate antagonist, on the effects of cocaine in humans. Six African American men completed this laboratory study, in which, following pretreatment with memantine (0 or 60 mg), they had 5 opportunities to smoke cocaine base (0, 12, 25, or 50 mg) or receive an alternative reinforcer ($5.00 merchandise voucher). Cocaine alone produced the well-documented dose-dependent increases in cardiovascular activity and ratings of positive mood. Maximal systolic blood pressure was elevated during memantine pretreatment days. Peak ratings of "I feel stimulated" and "I feel anxious" were also higher with memantine pretreatment. However, memantine pretreatment did not alter the choice to self-administer cocaine. These data suggest that memantine pretreatment may not be helpful in the treatment of cocaine dependence.
authors.affiliation: Division on Substance Abuse, New York State Psychiatric Institute, NY, USA.
authors.forename: Eric D
authors.initials: ED
authors.lastname: Collins
authors.forename: Suzanne K
authors.initials: SK
authors.lastname: Vosberg
authors.forename: Amie S
authors.initials: AS
authors.lastname: Ward
authors.forename: Margaret
authors.initials: M
authors.lastname: Haney
authors.forename: Richard W
authors.initials: RW
authors.lastname: Foltin
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000187:drug effects*; D003042:Cocaine / Q000494:pharmacology*; D019970:Cocaine-Related Disorders / Q000188:drug therapy; D004305:Dose-Response Relationship, Drug; D004644:Emotions / Q000187:drug effects*; D018691:Excitatory Amino Acid Antagonists / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D008297:Male; D008559:Memantine / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use; D012646:Self Administration
chemical_list: D018691:Excitatory Amino Acid Antagonists; D003042:Cocaine; D008559:Memantine