title: Undetectable serum anti-Müllerian hormone levels and occurrence of ongoing pregnancy.
abstract: OBJECTIVE
  To discuss, on the basis of the experience of two clinical cases and extensive literature review, the significance of extremely low levels of anti-Müllerian hormone (AMH), also known as Müllerian-inhibiting substance, in infertile women.
  
  
  METHODS
  Case report.
  
  
  METHODS
  University-based infertility clinic at a medical center in Switzerland.
  
  
  METHODS
  Two women, 29 and 41 years of age and with a 2- and 4-year history of secondary infertility, respectively.
  
  
  METHODS
  Clinical, radiological, and biological investigation of infertility, including repeated measurements of the serum AMH with serial ELISA assays.
  
  
  METHODS
  Levels of AMH and development of ongoing pregnancy.
  
  
  RESULTS
  Both women had a spontaneous ongoing pregnancy despite undetectable AMH levels.
  
  
  CONCLUSIONS
  Although it is helpful for day-to-day management of infertile patients, the predictive value of AMH for the occurrence of a spontaneous ongoing pregnancy has limits.
authors.affiliation: Unité d'Endocrinologie Gynécologique et Médecine de la Reproduction, Hôpitaux Universitaires de Genève, Département de Gynécologie et d'Obstétrique, Geneva, Switzerland. timothee.fraisse@escp-eap.net
authors.forename: Timothée
authors.initials: T
authors.lastname: Fraisse
authors.forename: Victoria
authors.initials: V
authors.lastname: Ibecheole
authors.forename: Isabelle
authors.initials: I
authors.lastname: Streuli
authors.forename: Paul
authors.initials: P
authors.lastname: Bischof
authors.forename: Dominique
authors.initials: D
authors.lastname: de Ziegler
mesh_terms: D000328:Adult; D054304:Anti-Mullerian Hormone / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005298:Fertility; D006801:Humans; D007247:Infertility, Female / Q000097:blood* / Q000503:physiopathology; D011237:Predictive Value of Tests; D011247:Pregnancy; D015203:Reproducibility of Results
chemical_list: D015415:Biomarkers; D054304:Anti-Mullerian Hormone