Heart rate dynamics during and after exercise in postoperative congenital heart disease patients. Their relation to cardiac autonomic nervous activity and intrinsic sinus node dysfunction.
BACKGROUND
Abnormal exercise-related heart rate (HR) dynamics, that is, blunted exercise HR response, lower peak HR, and delayed HR recovery after exercise, are associated with high morbidity and mortality in adults with acquired and congenital heart disease (CHD). However, the precise mechanisms underlying the abnormal HR dynamics remain unclear.


OBJECTIVE
The purpose of this study is to evaluate the precise contribution of cardiac autonomic nervous activity (CANA) and sinus node function on exercise-related HR dynamics in postoperative patients with CHD.


METHODS
We analyzed our previous data in 53 postoperative patients with CHD who had undergone pharmacologic evaluation, including intrinsic HR, and compared the results with HR dynamics.


RESULTS
Intrinsic HR (84% +/- 11%) was lower than the expected value and independently correlated with resting HR (P < .05). Univariate analysis demonstrated that all CANA indices significantly correlated with most HR dynamic parameters. On multivariate analysis, basal parasympathetic nervous activity significantly influenced all HR dynamics (P < .05-.0001), except for peak HR, whereas postsynaptic beta sensitivity of the sinus node significantly influenced all HR dynamics (P < .05-.001), except for early HR recovery. Resting plasma norepinephrine significantly correlated with all HR dynamics (P < .05-.001), except for resting HR.


CONCLUSIONS
Lower resting and peak HRs are independently associated with intrinsic sinus node dysfunction and abnormal sympathetic CANA, respectively. A blunted HR increase and delayed early HR recovery are independently associated with impaired sympathetic and parasympathetic CANAs with the greater influence on a blunted exercise HR increase.
Ohuchi
Hideo
H
Department of Pediatrics, National Cardiovascular Center, Osaka, Japan. hohuchi@hsp.ncvc.go.jp
Watanabe
Ken-ichi
K
Kishiki
Kanako
K
Wakisaka
Yuko
Y
Echigo
Shigeyuki
S
D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000378:metabolism; D002648:Child; D004562:Electrocardiography; D015444:Exercise; D005080:Exercise Test; D005260:Female; D005500:Follow-Up Studies; D006330:Heart Defects, Congenital / Q000503:physiopathology* / Q000601:surgery*; D006339:Heart Rate; D006801:Humans; D008297:Male; D045265:Natriuretic Peptides / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism; D011183:Postoperative Complications / Q000503:physiopathology; D011237:Predictive Value of Tests; D012849:Sinoatrial Node / Q000503:physiopathology*
D015415:Biomarkers; D045265:Natriuretic Peptides; D009638:Norepinephrine