title: Intake of added sugar and sugar-sweetened drink and serum uric acid concentration in US men and women.
abstract: Fructose-induced hyperuricemia might have a causal role in metabolic syndrome, hypertension, and other chronic disease. However, no study has investigated whether sugar added to foods or sugar-sweetened beverages, which are major sources of fructose, are associated with serum uric acid concentration in free-living populations. We examined the relationship between the intakes of added sugars and sugar-sweetened beverages and serum uric acid concentrations in the National Health and Nutrition Examination Survey 2001-2002, a nationally representative sample of men and women. We included 4073 subjects (1988 men and 2085 women) >18 years of age in the current study. Dietary intake was assessed by a single 24-hour recall. We used multivariate linear regression to adjust for age, gender, intake of energy and alcohol, body mass index, use of diuretics, beta-blockers, and other covariates. Male subjects in the highest intake quartile of estimated intake of added sugars or sugar-sweetened drinks had higher plasma uric acid concentrations than those in the lowest intake quartiles (P<0.001 for both) after adjusting for potential confounders, whereas we did not observe significant associations for females (P for trend>0.2; P for interaction <0.01). Further research is needed to confirm causality of these associations and the observed difference by gender.
authors.affiliation: Department of Nutrition, Harvard University School of Public Health, Boston, MA 02115, USA. xgao@hsph.harvard.edu
authors.forename: Xiang
authors.initials: X
authors.lastname: Gao
authors.forename: Lu
authors.initials: L
authors.lastname: Qi
authors.forename: Ning
authors.initials: N
authors.lastname: Qiao
authors.forename: Hyon K
authors.initials: HK
authors.lastname: Choi
authors.forename: Gary
authors.initials: G
authors.lastname: Curhan
authors.forename: Katherine L
authors.initials: KL
authors.lastname: Tucker
authors.forename: Alberto
authors.initials: A
authors.lastname: Ascherio
mesh_terms: D000328:Adult; D017677:Age Distribution; D001628:Beverages / Q000009:adverse effects*; D003430:Cross-Sectional Studies; D004040:Dietary Carbohydrates / Q000009:adverse effects*; D019422:Dietary Sucrose / Q000009:adverse effects; D005260:Female; D006801:Humans; D033461:Hyperuricemia / Q000453:epidemiology* / Q000209:etiology* / Q000503:physiopathology; D015994:Incidence; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D009749:Nutrition Surveys; D011336:Probability; D012307:Risk Factors; D012720:Severity of Illness Index; D017678:Sex Distribution; D014481:United States / Q000453:epidemiology; D014527:Uric Acid / Q000652:urine; D016482:Urinalysis
chemical_list: D004040:Dietary Carbohydrates; D019422:Dietary Sucrose; D014527:Uric Acid