title: The relationship of sterol regulatory element-binding protein cleavage-activation protein and apolipoprotein E gene polymorphisms with metabolic changes during weight reduction.
abstract: Sterol regulatory element-binding protein cleavage-activating protein (SCAP) and apolipoprotein E (apo E) regulate cellular and plasma lipid metabolism. Therefore, variations in the corresponding genes might influence weight reduction and obesity-associated metabolic changes. We investigated the relationships of SCAP (Ile796Val) and apo E polymorphisms on metabolic changes during weight reduction by using a 12-week very low-energy diet. Body composition, serum lipids, plasma glucose, and insulin were assessed in 78 healthy premenopausal women (initial body mass index, 34 +/- 4 kg/m(2); age, 40 +/- 4 years) before and after the intervention. The SCAP genotype groups did not differ in the responses of any parameters measured during weight reduction. Apo E did not differentiate the weight loss, but the changes in total and low-density lipoprotein cholesterol for the genotype groups apo E epsilon2/3, epsilon3/3, as well as epsilon3/4 and epsilon4/4 combined were -0.94 +/- 0.56 and -0.59 +/- 0.32, -0.71 +/- 0.49 and -0.49 +/- 0.45, and -0.55 +/- 0.47 and -0.37 +/- 0.39 mmol/L, respectively (P < .05 for both). In conclusion, neither the SCAP Ile796Val nor the apo E polymorphism was associated with weight loss in obese premenopausal women. However, the apo E-but not SCAP genotype-seems to be one of the modifying factors for serum cholesterol concentrations during very low-energy diet in obese premenopausal women.
authors.affiliation: Department of Pharmacological Sciences, Medical School, University of Tampere, 33014 Tampere, Finland. tuomo.nieminen@iki.fi
authors.forename: Tuomo
authors.initials: T
authors.lastname: Nieminen
authors.forename: Jussi
authors.initials: J
authors.lastname: Matinheikki
authors.forename: Arja
authors.initials: A
authors.lastname: Nenonen
authors.forename: Katriina
authors.initials: K
authors.lastname: Kukkonen-Harjula
authors.forename: Virpi
authors.initials: V
authors.lastname: Lindi
authors.forename: Päivi
authors.initials: P
authors.lastname: Hämelahti
authors.forename: Reijo
authors.initials: R
authors.lastname: Laaksonen
authors.forename: Yue-Mei
authors.initials: YM
authors.lastname: Fan
authors.forename: Mika
authors.initials: M
authors.lastname: Kähönen
authors.forename: Mikael
authors.initials: M
authors.lastname: Fogelholm
authors.forename: Terho
authors.initials: T
authors.lastname: Lehtimäki
mesh_terms: D000328:Adult; D001057:Apolipoproteins E / Q000235:genetics*; D031204:Caloric Restriction; D002784:Cholesterol / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics*; D008565:Membrane Proteins / Q000235:genetics*; D008875:Middle Aged; D011110:Polymorphism, Genetic; D015431:Weight Loss / Q000502:physiology*
chemical_list: D001057:Apolipoproteins E; D008078:Cholesterol, LDL; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; C102196:SREBP cleavage-activating protein; D002784:Cholesterol