title: Major depression in older medical inpatients predicts poor physical and mental health status over 12 months.
abstract: OBJECTIVE
  The aim of this study was to determine the 12-month effects upon physical and mental health status of a diagnosis of major or minor depression among older medical inpatients.
  
  
  METHODS
  Patients 65 years and older, admitted to the medical wards of two university-affiliated hospitals, with at most mild cognitive impairment, were screened for major and minor depression (Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition criteria). All depressed patients and a random sample of nondepressed patients were invited to participate. The physical functioning and mental health subscales of the Medical Outcomes Study 36-Item Short Form Health Survey (SF-36) were measured at baseline and at 3, 6 and 12 months.
  
  
  RESULTS
  Two hundred ten patients completed the SF-36 at baseline and at one or more follow-ups. In multiple linear regression analysis for longitudinal data, adjusting for baseline level of the SF-36 subscale outcome, severity of physical illness, premorbid disability, age, sex and other covariates, patients with major depression at baseline had lower SF-36 scores at follow-up, in comparison to patients with no depression [physical health, 9.22 (95% CI -15.52 to -2.93); mental health, 6.28 (95% CI -11.76 to -0.79)].
  
  
  CONCLUSIONS
  A diagnosis of major depression in cognitively intact older medical inpatients is associated with sustained poor physical and mental health status over the following 12 months.
authors.affiliation: Department of Clinical Epidemiology and Community Studies, St. Mary's Hospital, Montreal (Quebec), Canada H3T 1M5. jane.mccusker@mcgill.ca
authors.forename: Jane
authors.initials: J
authors.lastname: McCusker
authors.forename: Martin
authors.initials: M
authors.lastname: Cole
authors.forename: Antonio
authors.initials: A
authors.lastname: Ciampi
authors.forename: Eric
authors.initials: E
authors.lastname: Latimer
authors.forename: Sylvia
authors.initials: S
authors.lastname: Windholz
authors.forename: Eric
authors.initials: E
authors.lastname: Belzile
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003863:Depression / Q000150:complications*; D005260:Female; D006305:Health Status Indicators; D006306:Health Surveys; D006801:Humans; D007297:Inpatients / Q000523:psychology*; D016014:Linear Models; D008297:Male; D011446:Prospective Studies; D011792:Quebec / Q000453:epidemiology