[Research on the effect of atenolol on lidocaine pharmacokinetics in rats].
The aim was to determine the influence of atenolol on lidocaine pharmacokinetics in rats for one hour interval of time (average of a dental intervention). The study was carried out on 2 groups of Wistar rats treated with saline solution (0.5 ml/kg), respectively with atenolol (1.5 mg/kg), administered orally 24 hours and 3 hours before intraperitoneal administration of lidocaine (1.5 mg/kg). Blood samples were collected before and 5, 10, 20, 30, 60 minutes after lidocaine administration. Lidocaine plasma concentrations were determined by HPLC. Some pharmacokinetic parameters of lidocaine were statistically significant higher (p < 0.05, ANOVA) for the rats treated with atenolol compared with control group: Cmax (196.97 +/- 2.15 ng/ml vs. 125.29 +/- 2.90 ng/ml), AUD (7734.07 +/- 129.06 ng/ ml x min vs. 4478.57 +/- 296.61 ng/ml x min), AUC1 after 5 minutes (314.23 +/- 6.59 ng/ml x min vs. 190.71 +/- 19.75 ng/ml x min). Tmax was 20 minutes, similar for both groups.


CONCLUSIONS
local anesthesia with lidocaine might be enhanced in the presence of atenolol compared to controls.
Grădinaru
Irina
I
Universitatea de Medicină şi Farmacie Gr.T. Popa Iaşi, Facultatea de Medicină Dentară.
Ghiciuc
Cristina Mihaela
CM
Nechifor
M
M
Dumitriu
G
G
Doloca
A
A
D000465:Algorithms; D000772:Anesthesia, Local / Q000379:methods; D000779:Anesthetics, Local / Q000097:blood / Q000493:pharmacokinetics*; D000818:Animals; D001262:Atenolol / Q000494:pharmacology*; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D008012:Lidocaine / Q000097:blood / Q000493:pharmacokinetics*; D023421:Models, Animal; D051381:Rats; D017208:Rats, Wistar; D013565:Sympatholytics / Q000494:pharmacology*
D000779:Anesthetics, Local; D013565:Sympatholytics; D001262:Atenolol; D008012:Lidocaine