title: Automated red cell exchange procedures in patients with sickle cell disease.
abstract: In automated red cell exchange, about 60% of the patient's red blood cells are exchanged via apheresis for those of the donor. We report the outcome of 83 patients with sickle cell anemia (48 women and 35 men; age range, 17-49 years) who underwent a total of 196 apheresis procedures between December 2003 and October 2006 at our institution. We found that automated red cell exchange involving a reduced citrate infusion rate may provide benefit in the prevention or treatment of vaso-occlusive complications in patients with sickle cell disease and may be associated with protean effects on biochemical dynamics.
authors.affiliation: Department of Physiology, Baskent University, Faculty of Medicine, 06490-Ankara, Turkey.
authors.forename: Ilknur
authors.initials: I
authors.lastname: Kozanoglu
authors.forename: Can
authors.initials: C
authors.lastname: Boga
authors.forename: Hakan
authors.initials: H
authors.lastname: Ozdogu
authors.forename: Nurzen
authors.initials: N
authors.lastname: Sezgin
authors.forename: Ebru
authors.initials: E
authors.lastname: Kizilkilic
authors.forename: Mahmut
authors.initials: M
authors.lastname: Kural
mesh_terms: D000293:Adolescent; D000328:Adult; D000755:Anemia, Sickle Cell / Q000150:complications / Q000628:therapy*; D001157:Arterial Occlusive Diseases / Q000517:prevention & control; D001331:Automation; D001781:Blood Component Removal / Q000009:adverse effects / Q000379:methods*; D019343:Citric Acid; D017707:Erythrocyte Transfusion / Q000009:adverse effects / Q000379:methods*; D004912:Erythrocytes; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D016896:Treatment Outcome
chemical_list: D019343:Citric Acid