Determination of anti-inflammatory drugs and estrogens in water by HPLC with UV detection.
An analytical method based on LC and UV detection has been developed for the determination of anti-inflammatory compounds and estrogens in water samples. The drugs investigated were diclofenac, ketoprofen, ibuprofen, naproxen, clofibric acid, estriol, 17beta-estradiol, estrone and ethynylestradiol. The detection limits were in the range of 6-74 microg/L and 0.041 -0.16 mg/L for acidic pharmaceuticals and estrogens, respectively, using narrow-bore C18 analytical column. Analyte enrichment from water samples was achieved by SPE procedure using polymeric Strata-X cartridges. Average recoveries obtained from 2.5 L of surface water sample were in the range of 77-98%.
Stafiej
Anna
A
Department of Chemistry, Warsaw University, Warsaw, Poland.
Pyrzynska
Krystyna
K
Regan
Fiona
F
D000893:Anti-Inflammatory Agents / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004967:Estrogens / Q000032:analysis*; D006863:Hydrogen-Ion Concentration; D015394:Molecular Structure; D012680:Sensitivity and Specificity; D013056:Spectrophotometry, Ultraviolet / Q000379:methods; D014867:Water / Q000737:chemistry; D014874:Water Pollutants, Chemical / Q000032:analysis*
D000893:Anti-Inflammatory Agents; D004967:Estrogens; D014874:Water Pollutants, Chemical; D014867:Water