title: [Effects of hand hygiene on feline calicivirus inactivation and removal as norovirus surrogate treated with antiseptic hand rubbing, wet wipes, and functional water].
abstract: As a preventive action plan against gastroenteritis caused by the Norovirus (NV), we studied hand hygiene effects using with three hand rubbing products, four wet wipe products, and two functional water types using Feline Calicivirus as a Norovirus surrogate. After treatment using antiseptic hand rubbing products containing chlorhexidine, quaternary ammonium, and povidone-iodine, high inactivation detected by TCID50 was observed compared to products containing povidone-iodine, although no difference was seen in viral removal measured by the amount of viral genome copies in real-time-PCR. Among wet wipes soaked in chlorhexidine, quaternary ammonium, benzoic acid and PHMB, two groups showed viral inactivation and removal. Two products were more effective for functional water, viral decrease was seen in rinsing in running electrolyzed acid water and handwashing by soap. Results underscore the importance of selection in hand washing metheds (alternative soap and also) in preventing viral gastroenteritis.
authors.affiliation: Department of Microbiology, Tokyo Metropolitan Institute of Public Health.
authors.forename: Kohji
authors.initials: K
authors.lastname: Mori
authors.forename: Yukinao
authors.initials: Y
authors.lastname: Hayashi
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Akiba
authors.forename: Yayoi
authors.initials: Y
authors.lastname: Noguchi
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Yoshida
authors.forename: Akemi
authors.initials: A
authors.lastname: Kai
authors.forename: Sumio
authors.initials: S
authors.lastname: Yamada
authors.forename: Sachi
authors.initials: S
authors.lastname: Sakai
authors.forename: Motonobu
authors.initials: M
authors.lastname: Hara
mesh_terms: D000891:Anti-Infective Agents, Local / Q000494:pharmacology*; D019817:Benzoic Acid / Q000494:pharmacology; D017927:Calicivirus, Feline / Q000187:drug effects*; D002710:Chlorhexidine / Q000494:pharmacology; D006225:Hand / Q000821:virology*; D006235:Hand Disinfection / Q000379:methods; D006801:Humans; D006902:Hydroxymercuribenzoates / Q000494:pharmacology; D029322:Norovirus / Q000187:drug effects*; D011206:Povidone-Iodine / Q000494:pharmacology; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology; D038301:Virus Inactivation
chemical_list: D000891:Anti-Infective Agents, Local; D006902:Hydroxymercuribenzoates; D000644:Quaternary Ammonium Compounds; C030601:4-hydroxymercuribenzoate; D011206:Povidone-Iodine; D019817:Benzoic Acid; D002710:Chlorhexidine