title: Taylor-Aris dispersion in temperature gradient focusing.
abstract: Microfluidic temperature gradient focusing (TGF) uses an axial temperature gradient to induce a gradient in electrophoretic flux within a microchannel. When balanced with an opposing fluid flow, charged analytes simultaneously focus and separate according to their electrophoretic mobilities. We present a theoretical and experimental study of dispersion in TGF. We model the system using generalized dispersion analysis that yields a 1-D convection-diffusion equation that contains dispersion terms particular to TGF. We consider analytical solutions for the model under uniform temperature gradient conditions. Using a custom TGF experimental setup, we compare focusing measurements with the theoretical predictions. We find that the theory well represents the focusing behavior for flows within the Taylor-Aris dispersion regime.
authors.affiliation: Microfluidics Department, Sandia National Laboratories, Livermore, CA 94551-0969, USA. dhuber@sandia.gov
authors.forename: David E
authors.initials: DE
authors.lastname: Huber
authors.forename: Juan G
authors.initials: JG
authors.lastname: Santiago
mesh_terms: D046210:Microfluidic Analytical Techniques; D044085:Microfluidics; D008956:Models, Chemical; D013696:Temperature