title: Imbalance in seminal fluid MIF indicates male infertility.
abstract: Macrophage migration inhibitory factor (MIF) is a ubiquitous cytokine that functions in reproduction and plays an important role in sperm maturation and motility. Here we reveal a correlation between MIF levels in human seminal fluid and fertility status. We identify an abnormal biphasic profile of MIF in the seminal fluid of patients with impaired sperm parameters. Our findings may be of interest for the development of a diagnostic method for fertility status.
authors.affiliation: Laboratory of Medicinal Chemistry, The Feinstein Institute for Medical Research, Manhasset, NY 11030, USA.
authors.forename: Bayan
authors.initials: B
authors.lastname: Aljabari
authors.forename: Aldo E
authors.initials: AE
authors.lastname: Calogero
authors.forename: Anna
authors.initials: A
authors.lastname: Perdichizzi
authors.forename: Enzo
authors.initials: E
authors.lastname: Vicari
authors.forename: Raja
authors.initials: R
authors.lastname: Karaki
authors.forename: Tarek
authors.initials: T
authors.lastname: Lahloub
authors.forename: Rashed
authors.initials: R
authors.lastname: Zatari
authors.forename: Khaleel
authors.initials: K
authors.lastname: El-Abed
authors.forename: Ferdinando
authors.initials: F
authors.lastname: Nicoletti
authors.forename: Edmund J
authors.initials: EJ
authors.lastname: Miller
authors.forename: Valentin A
authors.initials: VA
authors.lastname: Pavlov
authors.forename: Yousef
authors.initials: Y
authors.lastname: Al-Abed
mesh_terms: D017304:Annexin A5 / Q000378:metabolism; D017209:Apoptosis / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007202:Indicators and Reagents / Q000378:metabolism; D007248:Infertility, Male; D008263:Macrophage Migration-Inhibitory Factors / Q000378:metabolism* / Q000494:pharmacology; D008297:Male; D011419:Propidium / Q000378:metabolism; D012661:Semen / Q000378:metabolism*; D013081:Sperm Motility / Q000187:drug effects; D013094:Spermatozoa / Q000187:drug effects
chemical_list: D017304:Annexin A5; D007202:Indicators and Reagents; D008263:Macrophage Migration-Inhibitory Factors; D011419:Propidium