Cell signaling: moving to a Wnt-Rap.
Non-canonical, beta-catenin-independent Wnt signaling regulates cell polarization and movements. A recent study reveals that casein kinase Iepsilon mediates an additional novel non-canonical Wnt pathway via the activation of the Rap1 GTPase during vertebrate gastrulation.
Habas
Raymond
R
Research Tower, Room 629, Department of Biochemistry, UMDNJ-Robert Wood Johnson School of Medicine, 675 Hoes Lane, Piscataway, New Jersey 08854, USA. habasra@umdnj.edu
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Xi
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D000818:Animals; D048149:Casein Kinase 1 epsilon / Q000378:metabolism*; D005775:Gastrula / Q000502:physiology; D018507:Gene Expression Regulation, Developmental; D015398:Signal Transduction; D051153:Wnt Proteins / Q000235:genetics / Q000378:metabolism*; D014981:Xenopus / Q000196:embryology* / Q000235:genetics / Q000378:metabolism; D029867:Xenopus Proteins / Q000235:genetics / Q000378:metabolism; D015027:Zebrafish / Q000196:embryology* / Q000235:genetics / Q000378:metabolism; D029961:Zebrafish Proteins / Q000235:genetics / Q000378:metabolism; D020827:rap1 GTP-Binding Proteins / Q000235:genetics / Q000378:metabolism*
D051153:Wnt Proteins; D029867:Xenopus Proteins; D029961:Zebrafish Proteins; D048149:Casein Kinase 1 epsilon; D020827:rap1 GTP-Binding Proteins