title: Long-term sound conditioning increases distortion product otoacoustic emission amplitudes and decreases olivocochlear efferent reflex strength.
abstract: The cochlea can be protected from acoustic trauma by moderate-level sound exposure. It is suggested that olivocochlear system may play a significant role in this protection. This study was performed to investigate distortion product otoacoustic emission (DPOAE) amplitudes changes and the efficiency of contralateral noise stimulation on DPOAE after conditioning noise exposure. Our results demonstrate that long-term conditioning can increase the DPOAE amplitudes at low frequencies (1.0-3.0 kHz) and decrease the olivocochlear efferent reflex strength at the same frequencies. The DPOAE amplitudes are partially restored to the preconditioning levels 2 weeks after conditioning; contralateral suppression also returns to the preconditioning levels. These results suggest that the enhancement of DPOAE amplitudes might be due to a decrease in olivocochlear efferent reflex strength.
authors.affiliation: Department of Otolaryngology--Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, People's Republic of China.
authors.forename: Jian-Hua
authors.initials: JH
authors.lastname: Peng
authors.forename: Ze-Zhang
authors.initials: ZZ
authors.lastname: Tao
authors.forename: Zhi-Wu
authors.initials: ZW
authors.lastname: Huang
mesh_terms: D000161:Acoustic Stimulation; D000222:Adaptation, Physiological; D000818:Animals; D003051:Cochlea / Q000502:physiology*; D004307:Dose-Response Relationship, Radiation; D007839:Functional Laterality; D006168:Guinea Pigs; D009847:Olivary Nucleus / Q000502:physiology*; D017084:Otoacoustic Emissions, Spontaneous; D012022:Reflex, Acoustic / Q000502:physiology*; D013016:Sound