Tarennane and tarennone, two novel chalcone constituents from Tarenna attenuata.
Two novel chalcone constituents, tarennane (1) and tarennone (2), together with nine known compounds, were isolated from the whole plant of Tarenna attenuata. By analysis of physical and spectroscopic data, the structures of new compounds were elucidated as (E)-4-[3-(4-hydroxy-3-methoxyphenyl)-acryl]-3,4,5-trimethoxycyclohexa-2,5-dienone (1) and 1,2-bis(3,5-dimethoxy-4-hydroxyphenyl)-3-hydroxypropan-1-one (2). These two compounds were tested for antioxidant activities in the MTT and DPPH assays. Compound 1 revealed potent antioxidant activities against H2O2-induced impairment in PC12 cells, but neither of them showed DPPH radical-scavenging activity with IC50 values of 181.1 and 210.3 microM, respectively.
Yang
Xian-Wen
XW
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, People's Republic of China.
Wang
Jun-Song
JS
Wang
Yue-Hu
YH
Xiao
Hai-Tao
HT
Hu
Xu-Jia
XJ
Mu
Shu-Zhen
SZ
Ma
Yan-Lin
YL
Lin
Hua
H
He
Hong-Ping
HP
Li
Ling
L
Hao
Xiao-Jiang
XJ
D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D047188:Chalcones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D019906:Nuclear Magnetic Resonance, Biomolecular; D016716:PC12 Cells; D051381:Rats; D019666:Rubiaceae / Q000737:chemistry*
D000975:Antioxidants; D047188:Chalcones; C521780:tarennane; C521779:tarennone