[Therapeutic effect of continuous veno-venous hemodiafiltration on systemic inflammatory response syndrome induced by cecum perforate peritonitis in piglets].
OBJECTIVE
Most of the therapeutic strategies for systemic inflammatory response syndrome (SIRS) is not effective. This study was to investigate the effect of continuous veno-venous hemodiafiltration (CVVHDF) on SIRS induced by cecum perforate peritonitis in piglets.


METHODS
Twelve piglets (weighing 7-9 kg) were randomly divided into two groups: control and CVVHDF (n=6). The piglets of both groups were subjected to a cecum puncture to induce peritonitis which caused SIRS. After SIRS occurred the piglets of the CVVHDF group immediately received the CVVHDF therapy for 6 hrs, with a blood flow rate of 20 mL/min, a replacement rate of 300 mL/h, and a dialysis rate of 600 mL/h. The heart rate (HR), mean artery blood pressure (MABP), respiratory rate (RR), arterial blood gas analysis and blood cells count were measured and recorded at baseline and onset of SIRS, and 2, 4 and 6 hrs after SIRS occurred.


RESULTS
When SIRS occurred, the HR and RR increased and the MABP, artery oxygen pressure (PaO2) and the count of white cells decreased in both groups. The HR of the CVVHDF group decreased significantly at 2 hrs (P < 0.05) and remained lower until 6 hrs after CVVHDF therapy (P < 0.01) compared with that of the control group. The RR of the CVVHDF group was significantly lower than that of the control group 6 hrs after CVVHDF therapy (P < 0.05). The MABP of the CVVHDF group increased significantly 4 and 6 hrs after therapy compared with that of the control group (P < 0.01, P < 0.05 respectively). There were no significant differences in temperature, PaO2 and blood cells count between the two groups during the experiment.


CONCLUSIONS
CVVHDF has a positive effect on hemodynamics in piglets with SIRS induced by cecum perforate peritonitis.
Gong
Jing-Yu
JY
Intensive Care Unit, Children's Hospital of Fudan University, Shanghai 200032, China.
Lu
Guo-Ping
GP
Dong
Kui-Ran
KR
Lu
Zhu-Jin
ZJ
Zhang
Ling-En
LE
D000818:Animals; D001794:Blood Pressure; D001831:Body Temperature; D002245:Carbon Dioxide / Q000097:blood; D002432:Cecum / Q000293:injuries; D002496:Central Venous Pressure; D005260:Female; D006339:Heart Rate; D017583:Hemodiafiltration; D007416:Intestinal Perforation / Q000150:complications; D008297:Male; D010100:Oxygen / Q000097:blood; D010538:Peritonitis / Q000150:complications*; D013552:Swine; D018746:Systemic Inflammatory Response Syndrome / Q000628:therapy*
D002245:Carbon Dioxide; D010100:Oxygen