Gypsophin: a novel alpha-glucosidase inhibitory cyclic peptide from the roots of Gypsophila oldhamiana.
An unusual new cyclic peptide with a pyrrolidine-2,5-dione unit, gypsophin (1), was isolated from Gypsophila oldhamiana. Its structure was elucidated by the spectroscopic evidences. The stereochemistry was determined by application of the Marfey's method and the single-crystal X-ray diffraction. Compound 1 exhibited inhibitory activity against alpha-glucosidase with IC50 of 305 microM.
Luo
Jian-Guang
JG
Department of Natural Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, PR China.
Wang
Xiao-Bing
XB
Ma
Li
L
Kong
Ling-Yi
LY
D029748:Caryophyllaceae / Q000737:chemistry*; D065089:Glycoside Hydrolase Inhibitors; D008958:Models, Molecular; D010456:Peptides, Cyclic / Q000737:chemistry* / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry*
D065089:Glycoside Hydrolase Inhibitors; D010456:Peptides, Cyclic; C524173:gypsophin