Effects of tribromoethanol-medetomidine combination on cycling and ovariectomized Sprague-Dawley rats.
Although commonly used to induce anesthesia in rodents, the effective dose of tribromoethanol is associated with various side effects. The authors previously found that a tribromoethanol-medetomidine combination reduced the dose of tribromoethanol necessary for effective anesthesia in male Sprague-Dawley rats, an effect reversible by atipamezole. Here, the authors focus on the effect of this anesthetic combination in female Sprague-Dawley rats, its effects on their estrous cycles, and its efficacy at low sex hormone levels. Their results suggest that the anesthetic combination is effective in female rats, does not affect their estrous cycles, and works even when hormone levels are low, such as after ovariectomy.
Gopalan
Chaya
C
St. Louis Community College, 3400 Pershall Rd., St. Louis, MO 63135, USA. cgopalan@stlcc.edu
Simmons
Ariel S
AS
Mungal
Giselle K
GK
Wilson
Thomas J
TJ
Sieve
Margaret
M
Salem
Dianne K
DK
Rivkin
Mark A
MA
D000777:Anesthetics / Q000008:administration & dosage* / Q000009:adverse effects; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004971:Estrus / Q000187:drug effects*; D000431:Ethanol / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D005260:Female; D020926:Medetomidine / Q000008:administration & dosage* / Q000009:adverse effects; D010052:Ovariectomy / Q000662:veterinary; D051381:Rats; D017207:Rats, Sprague-Dawley
D000777:Anesthetics; C062527:tribromoethanol; D000431:Ethanol; D020926:Medetomidine