title: Synthesis and biological evaluation of conformationally constrained analogues of the antitubercular agent ethambutol.
abstract: Three (S)-prolinol-derived conformationally restricted analogues of the antitubercular agent ethambutol were prepared and tested against Mycobacterium tuberculosis.
authors.affiliation: Laboratoire de Synthèse et Physicochimie de Molécules d'Intérêt Biologique, UMR 5068, Université Paul Sabatier, 31062 Toulouse, Cedex 9, France.
authors.forename: Vanessa
authors.initials: V
authors.lastname: Faugeroux
authors.forename: Yves
authors.initials: Y
authors.lastname: Génisson
authors.forename: Yahya
authors.initials: Y
authors.lastname: Salma
authors.forename: Patricia
authors.initials: P
authors.lastname: Constant
authors.forename: Michel
authors.initials: M
authors.lastname: Baltas
mesh_terms: D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015195:Drug Design; D004977:Ethambutol / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D007097:Imines / Q000737:chemistry; D008958:Models, Molecular; D008968:Molecular Conformation; D009169:Mycobacterium tuberculosis / Q000187:drug effects
chemical_list: D000995:Antitubercular Agents; D007097:Imines; D004977:Ethambutol