title: Pentylenetetrazol-induced seizures are not altered by pre- or post-drug exposure to a 50 Hz magnetic field.
abstract: OBJECTIVE
  To investigate whether pre- and post-drug magnetic field (MF) exposure of 50 Hz, 0.2 mT has any significant effect on pentylenetetrazol (PTZ)-induced seizures in mice.
  
  
  METHODS
  MF was generated by a pair of Helmholtz coils. Seizures were induced by PTZ injection intraperitoneally (i.p.) at a dose of 60 mg/kg. A total of 48 locally bred adult female mice 25-35 g in weight were used. Latency to seizure, total seizure duration, and mortality were recorded for each mouse.
  
  
  RESULTS
  Neither pre- nor post-drug exposure to a 50 Hz, 0.2 mT MF was found to have any effect on PTZ-induced epileptic seizures or mortality rates in mice.
  
  
  CONCLUSIONS
  The present study failed to provide any support for a therapeutic potential of a 50 Hz, 0.2 mT MF for epilepsy.
authors.affiliation: Department of Biophysics, Gazi University Medical Faculty, and Gazi Non-Ionizing Radiation Protection Center, Ankara, Turkey. canseven@gazi.edu.tr
authors.forename: Ayse G
authors.initials: AG
authors.lastname: Canseven
authors.forename: Zuhal Aktuna
authors.initials: ZA
authors.lastname: Keskil
authors.forename: Semih
authors.initials: S
authors.lastname: Keskil
authors.forename: Nesrin
authors.initials: N
authors.lastname: Seyhan
mesh_terms: D000818:Animals; D001921:Brain / Q000503:physiopathology* / Q000528:radiation effects*; D004560:Electricity; D004574:Electromagnetic Fields; D005260:Female; D051379:Mice; D010433:Pentylenetetrazole; D012640:Seizures / Q000139:chemically induced* / Q000503:physiopathology* / Q000517:prevention & control; D015996:Survival Rate
chemical_list: D010433:Pentylenetetrazole