Workgroup report: incorporating in vitro alternative methods for developmental neurotoxicity into international hazard and risk assessment strategies.
This is the report of the first workshop on Incorporating In Vitro Alternative Methods for Developmental Neurotoxicity (DNT) Testing into International Hazard and Risk Assessment Strategies, held in Ispra, Italy, on 19-21 April 2005. The workshop was hosted by the European Centre for the Validation of Alternative Methods (ECVAM) and jointly organized by ECVAM, the European Chemical Industry Council, and the Johns Hopkins University Center for Alternatives to Animal Testing. The primary aim of the workshop was to identify and catalog potential methods that could be used to assess how data from in vitro alternative methods could help to predict and identify DNT hazards. Working groups focused on two different aspects: a) details on the science available in the field of DNT, including discussions on the models available to capture the critical DNT mechanisms and processes, and b) policy and strategy aspects to assess the integration of alternative methods in a regulatory framework. This report summarizes these discussions and details the recommendations and priorities for future work.
Coecke
Sandra
S
ECVAM-European Centre for the Validation of Alternative Methods, Institute for Health and Consumer Protection, European Commission, Joint Research Center, Ispra, Italy. sandra.coecke@jrc.it
Goldberg
Alan M
AM
Allen
Sandra
S
Buzanska
Leonora
L
Calamandrei
Gemma
G
Crofton
Kevin
K
Hareng
Lars
L
Hartung
Thomas
T
Knaut
Holger
H
Honegger
Paul
P
Jacobs
Miriam
M
Lein
Pamela
P
Li
Abby
A
Mundy
William
W
Owen
David
D
Schneider
Steffen
S
Silbergeld
Ellen
E
Reum
Torsten
T
Trnovec
Tomas
T
Monnet-Tschudi
Florianne
F
Bal-Price
Anna
A
D000826:Animal Testing Alternatives / Q000331:legislation & jurisprudence / Q000592:standards*; D000818:Animals; D006801:Humans; D066298:In Vitro Techniques; D008954:Models, Biological; D009420:Nervous System / Q000187:drug effects* / Q000196:embryology / Q000254:growth & development; D018675:Toxicity Tests / Q000379:methods*; D054928:Validation Studies as Topic; D015262:Xenobiotics / Q000633:toxicity*
D015262:Xenobiotics