Study of poly(L-lactide) microparticles based on supercritical CO2.
Poly(L-lactide) (PLLA) microparticles were prepared in supercritical anti-solvent process. The effects of several key factors on surface morphology, and particle size and particle size distribution were investigated. These factors included initial drops size, saturation ratio of PLLA solution, pressure, temperature, concentration of the organic solution, the flow rate of the solution and molecular weight of PLLA. The results indicated that the saturation ratio of PLLA solution, concentration of the organic solution and flow rate of the solution played important roles on the properties of products. Various microparticles with the mean particle size ranging from 0.64 to 6.64 microm, could be prepared by adjusting the operational parameters. Fine microparticles were obtained in a process namely solution-enhanced dispersion by supercritical fluids (SEDS) process with dichloromethane/acetone mixture as solution.
Chen
Ai-Zheng
AZ
College of Materials Science and Engineering, Sichuan University, Chengdu, 610064 Sichuan, China.
Pu
Xi-Ming
XM
Kang
Yun-Qing
YQ
Liao
Li
L
Yao
Ya-Dong
YD
Yin
Guang-Fu
GF
D002245:Carbon Dioxide / Q000737:chemistry; D025924:Chromatography, Supercritical Fluid / Q000295:instrumentation; D008863:Microspheres; D008954:Models, Biological; D008970:Molecular Weight; D009994:Osmolar Concentration; D010316:Particle Size; D011091:Polyesters / Q000032:analysis* / Q000737:chemistry*; D011312:Pressure; D012996:Solutions / Q000032:analysis; D013696:Temperature
D011091:Polyesters; D012996:Solutions; D002245:Carbon Dioxide; C033616:poly(lactide)