Delay discounting of cocaine by rhesus monkeys.
The present, subjective value of a reinforcer typically decreases as a function of the delay to its receipt, a phenomenon termed delay discounting. Delay discounting, which is assumed to reflect impulsivity, is hypothesized to play an important role in drug abuse. The present study examined delay discounting of cocaine injections by rhesus monkeys. Subjects were studied on a discrete-trials task in which they chose between 2 doses of cocaine: a smaller, immediate dose and a larger, delayed dose. The immediate dose varied between 0.012 and 0.4 mg/kg/injection, whereas the delayed dose was always 0.2 mg/kg/injection and was delivered after a delay that varied between 0 and 300 s in different conditions. At each delay, the point at which a monkey chose the immediate and delayed doses equally often (i.e., the ED50) provided a measure of the present, subjective value of the delayed dose. Dose-response functions for the immediate dose shifted to the left as delay increased. The amount of the immediate dose predicted to be equal in subjective value to the delayed dose decreased as a function of the delay, and hyperbolic discounting functions provided good fits to the data (median R(2)=.86). The current approach may provide the basis for an animal model of the effect of delay on the subjective value of drugs of abuse.
Woolverton
William L
WL
Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS 39216, USA. wwoolverton@psychiatry.umsmed.edu
Myerson
Joel
J
Green
Leonard
L
D000818:Animals; D002755:Choice Behavior / Q000187:drug effects*; D003042:Cocaine / Q000008:administration & dosage* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D007175:Impulsive Behavior; D007262:Infusions, Intravenous; D008253:Macaca mulatta; D008297:Male; D015999:Multivariate Analysis; D012055:Reinforcement Schedule; D012646:Self Administration
D003042:Cocaine