Synthesis of diverse lactam carboxamides leading to the discovery of a new transcription-factor inhibitor.
Ng
Pui Yee
PY
The Broad Institute of Harvard and MIT, 7 Cambridge Center, Cambridge, MA 02142, USA.
Tang
Yuchen
Y
Knosp
Wendy M
WM
Stadler
H Scott
HS
Shaw
Jared T
JT
D000577:Amides / Q000138:chemical synthesis / Q000737:chemistry*; D002264:Carboxylic Acids / Q000737:chemistry*; D004247:DNA / Q000737:chemistry / Q000378:metabolism; D018398:Homeodomain Proteins / Q000737:chemistry / Q000378:metabolism; D007769:Lactams / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D013237:Stereoisomerism; D014157:Transcription Factors / Q000037:antagonists & inhibitors* / Q000378:metabolism
D000577:Amides; D002264:Carboxylic Acids; D018398:Homeodomain Proteins; D007769:Lactams; D014157:Transcription Factors; C099959:homeobox protein HOXA13; D004247:DNA