Harzianums A and B produced by a fungal strain, Hypocrea sp. F000527, and their cytotoxicity against tumor cell lines.
A new compound, harzianum B (1), was isolated from the culture broth of a fungal strain, Hypocrea sp. F000527, together with a known trichothecene, harzianum A (2). Its structure was determined by spectroscopic analyses including HRFAB-MS and various (1)H NMR and (13)C NMR spectral data. Harzianum B (1) was characterised as (E,Z,E)-2', 4', 6'-octatriendioic acid esterified on the 4beta-hydroxyl group of trichodermol. Harzianums A (2) and B (1) showed cytotoxicity against several human cancer cell lines.
Jin
H-Z
HZ
School of Pharmacy, Shanghai, Jiao Tong University, Shanghai 200240, China. kimhz@sjtu.edu.cu
Lee
J-H
JH
Zhang
W-D
WD
Lee
H-B
HB
Hong
Y-S
YS
Kim
Y-H
YH
Lee
J-J
JJ
D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D006801:Humans; D035901:Hypocrea / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D014255:Trichothecenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D000970:Antineoplastic Agents; D014255:Trichothecenes; C087546:harzianum A