Peri-implant bone regeneration with calcium sulfate: a light and transmission electron microscopy case report.
BACKGROUND
Calcium sulfate is a simple, biocompatible material with a very long, safe clinical history in several different fields of medicine. It is a rapidly resorbing material that leaves behind calcium phosphate lattice, which promotes bone regeneration.


OBJECTIVE
The aim of this study was a histological and ultrastructural evaluation of the tissues in a peri-implant site regenerated with calcium sulfate.


METHODS
The specimens were processed for observation under light and transmission electron microscopes.


RESULTS
In light microscopy, trabecular bone was present. No remnants of calcium sulfate were present. Transmission electron microscopy showed, in the areas of the interface with the implant surface, features of mature bone with many osteocytes. An amorphous layer and/or osteoid seam separated this mature bone from the metal surface.


CONCLUSIONS
The results confirm the high biocompatibility and rapid resorption of calcium sulfate.
Scarano
Antonio
A
Department of Oral Histology and Biomaterials, Implant Retrieval Center, Dental School, University of Chieti, Via F. Sciucchi 63, 66100 Chieti, Italy.
Orsini
Giovanna
G
Pecora
Gabriele
G
Iezzi
Giovanna
G
Perrotti
Vittoria
V
Piattelli
Adriano
A
D020341:Absorbable Implants; D000539:Alveolar Process / Q000473:pathology* / Q000503:physiopathology; D000540:Alveolar Ridge Augmentation / Q000379:methods*; D001672:Biocompatible Materials / Q000627:therapeutic use*; D001857:Bone Matrix / Q000648:ultrastructure; D001861:Bone Regeneration / Q000502:physiology*; D018786:Bone Substitutes / Q000627:therapeutic use*; D002133:Calcium Sulfate / Q000627:therapeutic use*; D015921:Dental Implants; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008437:Maxilla / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D046529:Microscopy, Electron, Transmission; D008875:Middle Aged; D016348:Osseointegration / Q000502:physiology; D010006:Osteoblasts / Q000648:ultrastructure; D010010:Osteoclasts / Q000648:ultrastructure; D010011:Osteocytes / Q000648:ultrastructure
D001672:Biocompatible Materials; D018786:Bone Substitutes; D015921:Dental Implants; D002133:Calcium Sulfate