title: Rapid growth and regression of intracranial meningiomas in lymphangioleiomyomatosis: case report.
abstract: BACKGROUND
  Lymphangioleiomyomatosis is a progressive interstitial lung disease that affects young women. It has been suggested that estrogens play a role in its evolution, and progesterone therapy is often provided in these cases.
  
  
  METHODS
  We present a case of a postmenopausal woman with LAM treated with progesterone; subsequently, rapid growth of multiple intracranial meningiomas was observed. One prominent lesion was excised, and 3 other lesions regressed spontaneously over 2 years.
  
  
  CONCLUSIONS
  This is a rare case of a non-pregnancy-related regression of meningiomas in a woman affected by LAM. The significance of this association and the hormonal treatment of the disease are discussed.
authors.affiliation: Division of Neurosurgery and Service of Pathology, Bellaria Hospital and Respiratory Pathophysiology, S. Orsola Policlinic, Bologna 40100, Italy. Electronic address: eugenio.pozzati@ausl.bologna.it.
authors.forename: Eugenio
authors.initials: E
authors.lastname: Pozzati
authors.affiliation: Division of Neurosurgery and Service of Pathology, Bellaria Hospital and Respiratory Pathophysiology, S. Orsola Policlinic, Bologna 40100, Italy.
authors.forename: Mino
authors.initials: M
authors.lastname: Zucchelli
authors.affiliation: Division of Neurosurgery and Service of Pathology, Bellaria Hospital and Respiratory Pathophysiology, S. Orsola Policlinic, Bologna 40100, Italy.
authors.forename: Mario
authors.initials: M
authors.lastname: Schiavina
authors.affiliation: Division of Neurosurgery and Service of Pathology, Bellaria Hospital and Respiratory Pathophysiology, S. Orsola Policlinic, Bologna 40100, Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Contini
authors.affiliation: Division of Neurosurgery and Service of Pathology, Bellaria Hospital and Respiratory Pathophysiology, S. Orsola Policlinic, Bologna 40100, Italy.
authors.forename: Maria Pia
authors.initials: MP
authors.lastname: Foschini
mesh_terms: D000075202:Contraindications; D005260:Female; D006801:Humans; D018192:Lymphangioleiomyomatosis / Q000188:drug therapy* / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008577:Meningeal Neoplasms / Q000139:chemically induced* / Q000473:pathology; D008579:Meningioma / Q000139:chemically induced* / Q000473:pathology; D008875:Middle Aged; D011374:Progesterone / Q000009:adverse effects*; D011372:Progestins / Q000009:adverse effects*
chemical_list: D011372:Progestins; D011374:Progesterone