The analgesic efficacy of continuous elastomeric pump ropivacaine wound instillation after appendectomy.
OBJECTIVE
To evaluate the analgesic efficacy and safety of ropivacaine 0.2% when administered continuously via elastomeric pump after appendectomy.


METHODS
Prospective, randomized, double-blinded study.


METHODS
Surgical ward of a university hospital.


METHODS
96 ASA physical status I and II patients of at least 14 years of age, undergoing appendectomy through a McBurney incision.


METHODS
Patients were randomly assigned into two groups: 500 mg of ropivacaine in 48 hours (10 mL of 0.2% ropivacaine 20 mg, starter dose plus 5 mL/h continuous wound infusion via elastomeric pump device; n = 48) in the experimental group and 250 mL of normal saline, as placebo, in the control group.


METHODS
Postappendectomy pain, measured either with a simple verbal scale or with a visual analog scale, parenteral analgesic consumption, and global satisfaction were all measured.


RESULTS
A reduction in postoperative pain was observed in the ropivacaine group. Degree of pain, with a simple verbal scale measurement of severe and unbearable, was significantly lower in the ropivacaine group than in the normal saline group from time 0 to 24 hours at rest and from time 0 to 36 hours on coughing. A significant lower pain intensity (visual analog scale) was found in the ropivacaine group both at rest and on coughing, beginning at three hours and continuing to 36 hours postoperatively. The mean number of rescue analgesic doses was significantly lower in the ropivacaine group. There were no statistically significant differences in the frequency of adverse events between the two groups.


CONCLUSIONS
Wound instillation with ropivacaine 0.2% is a useful, practical, and safe method for management of postoperative pain after appendectomy.
Ansaloni
Luca
L
Unit of Emergency Surgery, Department of Surgical and Anaesthesiological Sciences, University of Bologna, Sant'Orsola-Malpighi Hospital, 40138 Bologna, Italy. lansaloni@orsola-malpighi.med.unibo.it
Agnoletti
Vanni
V
Bettini
Dario
D
Caira
Antonio
A
Calli
Morena
M
Catena
Fausto
F
Celotti
Miria
M
De Cataldis
Angelo
A
Gagliardi
Stefano
S
Gasperoni
Emmanuel
E
Leone
Antonio
A
Melotti
Rita Maria
RM
Potalivo
Antonella
A
Simoncini
Gabriella
G
Taffurelli
Mario
M
Di Nino
Gianfranco
G
D000293:Adolescent; D000328:Adult; D000577:Amides / Q000008:administration & dosage* / Q000009:adverse effects; D000779:Anesthetics, Local / Q000008:administration & dosage*; D001062:Appendectomy; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007260:Infusion Pumps; D008297:Male; D010149:Postoperative Pain / Q000188:drug therapy*; D011446:Prospective Studies; D000077212:Ropivacaine; D014947:Wounds and Injuries
D000577:Amides; D000779:Anesthetics, Local; D000077212:Ropivacaine