title: Antinociceptive activity of Maytenus rigida stem bark.
abstract: Ethanol extract of Maytenus rigida stem bark and its fractions were assessed for antinociceptive activity in tail-flick test in rats. The activity was located in the chloroform, ethyl acetate and aq.methanol fractions. Phytochemical screening revealed that catechin was the only common class of compounds present on the ethanol extract as well as on the active fractions. 4'-Methylepigallocatechin, isolated from the ethyl acetate and aq.methanol fractions, showed antinociceptive effect in the tail-flick test (75 mg/kg; p.o.), which was reversed by the opiate antagonist naloxone (3 mg/kg; i.p.).
authors.affiliation: Departamento de Fisiologia, Laboratório de Farmacologia/Universidade Federal de Sergipe, 49160-000, São Cristóvão /SE, Brazil. kellyanesdias@yahoo.com.br
authors.forename: Kellyane S
authors.initials: KS
authors.lastname: Dias
authors.forename: Maxsuel S
authors.initials: MS
authors.lastname: Marques
authors.forename: Igor A C
authors.initials: IA
authors.lastname: Menezes
authors.forename: Thiago C
authors.initials: TC
authors.lastname: Santos
authors.forename: Aline B L
authors.initials: AB
authors.lastname: Silva
authors.forename: Charles S
authors.initials: CS
authors.lastname: Estevam
authors.forename: Antônio E G
authors.initials: AE
authors.lastname: Sant'Ana
authors.forename: Cosimo
authors.initials: C
authors.lastname: Pizza
authors.forename: Angelo R
authors.initials: AR
authors.lastname: Antoniolli
authors.forename: Rosilene M
authors.initials: RM
authors.lastname: Marçal
mesh_terms: D000700:Analgesics / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D004305:Dose-Response Relationship, Drug; D006358:Hot Temperature; D008297:Male; D029755:Maytenus; D010146:Pain / Q000517:prevention & control*; D010147:Pain Measurement / Q000187:drug effects; D008517:Phytotherapy; D024301:Plant Bark; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018547:Plant Stems; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000700:Analgesics; D010936:Plant Extracts