[Association between uroguanylin G-247A polymorphism and blood pressure/fluid and electrolytes homeostasis].
OBJECTIVE
To observe the association between uroguanylin G-247A polymorphism and blood pressure/fluid and electrolytes homeostasis.


METHODS
Uroguanylin genotype was determined by restrictive fragment length polymorphism (RFLP) and blood pressure as well as fluid and electrolytes homeostasis were measured in 442 volunteers from Jing Ning County, ZheJiang Province. Data were analyzed by ANOVA, Generalized Estimating Equations (GEE), and Quantitative Transmission Disequilibrium Test (QTDT).


RESULTS
Ten uroguanylin gene polymorphisms were detected in 40 subjects by direct sequencing, all were reported in the NCBI SNP database. We selected the G-247A polymorphism for genotyping. Compared with G allele carriers, AA homozygotes had a higher urinary volume (P = 0.08), higher excretions of sodium (P = 0.07) and potassium (P < 0.001), but similar systolic and diastolic blood pressure (P > 0.32) both before and after adjustment for sex, age, body-mass index, current smoking, alcohol intake, and antihypertensive treatment.


CONCLUSIONS
The uroguanylin G-247A polymorphism was associated with urinary volume and sodium and potassium excretions.
Guo
Hui-feng
HF
Centre for Epidemiological Studies and Clinical Trials, Ruijin Hospital, Shanghai Jiao Tong University Medical School, Shanghai 200025, China.
Gao
Ping-jin
PJ
Li
Yan
Y
Zhu
Ding-liang
DL
Wang
Ji-guang
JG
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D001794:Blood Pressure; D002648:Child; D005260:Female; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000453:epidemiology / Q000235:genetics; D008297:Male; D008875:Middle Aged; D045265:Natriuretic Peptides / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D014882:Water-Electrolyte Balance; D055815:Young Adult
D045265:Natriuretic Peptides; C084362:uroguanylin