Plasma surfactant protein D levels and the relation to body mass index in a chinese population.
Surfactant protein D (SP-D) is a member of the collectin family and is an important component of the pulmonary innate host defence. The protein has a widespread distribution in the human body and is present in multiple epithelia, in endothelium and in blood. Various studies have looked at the relationship between serum SP-D levels and pulmonary inflammatory diseases. The SP-D distribution has been most thoroughly described in European populations and appears with a broad range of serum values highly influenced by genetic factors. In the present study, we investigated the plasma SP-D distribution in a Chinese population from the Tai An region comprising 268 individuals. We found that (i) plasma SP-D in the Chinese population was distributed with a median value of 380.2 ng/ml (324.9; 418.7) and a range from 79.4 to 3965.3 ng/ml, (ii) significantly higher plasma SP-D in men than in women, and no significant effect of age, and (iii) a significant inverse association between serum SP-D and body mass index (BMI) (P = 0.012). The data indicate that racial differences in SP-D expression exist as the median plasma SP-D in the Chinese population was approximately two times lower than the median serum SP-D previously measured in a Danish population using the same immuno-assay. The inverse association between serum SP-D and BMI found in the Chinese population indicates that serum SP-D is related to obesity in similar ways in Chinese and Danes.
Zhao
X M
XM
College of Medicine, Shandong University, Ji-nan, ChinaMedicine, Taishan Medical University, Tai-an, ChinaClinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht, The NetherlandsMedical Biotechnology Center, University of Southern Denmark, Odense, Denmark.
Wu
Y P
YP
College of Medicine, Shandong University, Ji-nan, ChinaMedicine, Taishan Medical University, Tai-an, ChinaClinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht, The NetherlandsMedical Biotechnology Center, University of Southern Denmark, Odense, Denmark.
Wei
R
R
College of Medicine, Shandong University, Ji-nan, ChinaMedicine, Taishan Medical University, Tai-an, ChinaClinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht, The NetherlandsMedical Biotechnology Center, University of Southern Denmark, Odense, Denmark.
Cai
H X
HX
College of Medicine, Shandong University, Ji-nan, ChinaMedicine, Taishan Medical University, Tai-an, ChinaClinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht, The NetherlandsMedical Biotechnology Center, University of Southern Denmark, Odense, Denmark.
Tornoe
I
I
College of Medicine, Shandong University, Ji-nan, ChinaMedicine, Taishan Medical University, Tai-an, ChinaClinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht, The NetherlandsMedical Biotechnology Center, University of Southern Denmark, Odense, Denmark.
Han
J J
JJ
College of Medicine, Shandong University, Ji-nan, ChinaMedicine, Taishan Medical University, Tai-an, ChinaClinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht, The NetherlandsMedical Biotechnology Center, University of Southern Denmark, Odense, Denmark.
Wang
Y
Y
College of Medicine, Shandong University, Ji-nan, ChinaMedicine, Taishan Medical University, Tai-an, ChinaClinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht, The NetherlandsMedical Biotechnology Center, University of Southern Denmark, Odense, Denmark.
De Groot
P G
PG
College of Medicine, Shandong University, Ji-nan, ChinaMedicine, Taishan Medical University, Tai-an, ChinaClinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht, The NetherlandsMedical Biotechnology Center, University of Southern Denmark, Odense, Denmark.
Holmskov
U
U
College of Medicine, Shandong University, Ji-nan, ChinaMedicine, Taishan Medical University, Tai-an, ChinaClinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht, The NetherlandsMedical Biotechnology Center, University of Southern Denmark, Odense, Denmark.
Xia
Z L
ZL
College of Medicine, Shandong University, Ji-nan, ChinaMedicine, Taishan Medical University, Tai-an, ChinaClinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht, The NetherlandsMedical Biotechnology Center, University of Southern Denmark, Odense, Denmark.
Sorensen
G L
GL
College of Medicine, Shandong University, Ji-nan, ChinaMedicine, Taishan Medical University, Tai-an, ChinaClinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht, The NetherlandsMedical Biotechnology Center, University of Southern Denmark, Odense, Denmark.
D000328:Adult; D000367:Age Factors; D044466:Asian People / Q000208:ethnology; D015992:Body Mass Index; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood*; D037663:Pulmonary Surfactant-Associated Protein D / Q000097:blood*; D012737:Sex Factors
D037663:Pulmonary Surfactant-Associated Protein D