title: Workgroup report: incorporating in vitro alternative methods for developmental neurotoxicity into international hazard and risk assessment strategies.
abstract: This is the report of the first workshop on Incorporating In Vitro Alternative Methods for Developmental Neurotoxicity (DNT) Testing into International Hazard and Risk Assessment Strategies, held in Ispra, Italy, on 19-21 April 2005. The workshop was hosted by the European Centre for the Validation of Alternative Methods (ECVAM) and jointly organized by ECVAM, the European Chemical Industry Council, and the Johns Hopkins University Center for Alternatives to Animal Testing. The primary aim of the workshop was to identify and catalog potential methods that could be used to assess how data from in vitro alternative methods could help to predict and identify DNT hazards. Working groups focused on two different aspects: a) details on the science available in the field of DNT, including discussions on the models available to capture the critical DNT mechanisms and processes, and b) policy and strategy aspects to assess the integration of alternative methods in a regulatory framework. This report summarizes these discussions and details the recommendations and priorities for future work.
authors.affiliation: ECVAM-European Centre for the Validation of Alternative Methods, Institute for Health and Consumer Protection, European Commission, Joint Research Center, Ispra, Italy. sandra.coecke@jrc.it
authors.forename: Sandra
authors.initials: S
authors.lastname: Coecke
authors.forename: Alan M
authors.initials: AM
authors.lastname: Goldberg
authors.forename: Sandra
authors.initials: S
authors.lastname: Allen
authors.forename: Leonora
authors.initials: L
authors.lastname: Buzanska
authors.forename: Gemma
authors.initials: G
authors.lastname: Calamandrei
authors.forename: Kevin
authors.initials: K
authors.lastname: Crofton
authors.forename: Lars
authors.initials: L
authors.lastname: Hareng
authors.forename: Thomas
authors.initials: T
authors.lastname: Hartung
authors.forename: Holger
authors.initials: H
authors.lastname: Knaut
authors.forename: Paul
authors.initials: P
authors.lastname: Honegger
authors.forename: Miriam
authors.initials: M
authors.lastname: Jacobs
authors.forename: Pamela
authors.initials: P
authors.lastname: Lein
authors.forename: Abby
authors.initials: A
authors.lastname: Li
authors.forename: William
authors.initials: W
authors.lastname: Mundy
authors.forename: David
authors.initials: D
authors.lastname: Owen
authors.forename: Steffen
authors.initials: S
authors.lastname: Schneider
authors.forename: Ellen
authors.initials: E
authors.lastname: Silbergeld
authors.forename: Torsten
authors.initials: T
authors.lastname: Reum
authors.forename: Tomas
authors.initials: T
authors.lastname: Trnovec
authors.forename: Florianne
authors.initials: F
authors.lastname: Monnet-Tschudi
authors.forename: Anna
authors.initials: A
authors.lastname: Bal-Price
mesh_terms: D000826:Animal Testing Alternatives / Q000331:legislation & jurisprudence / Q000592:standards*; D000818:Animals; D006801:Humans; D066298:In Vitro Techniques; D008954:Models, Biological; D009420:Nervous System / Q000187:drug effects* / Q000196:embryology / Q000254:growth & development; D018675:Toxicity Tests / Q000379:methods*; D054928:Validation Studies as Topic; D015262:Xenobiotics / Q000633:toxicity*
chemical_list: D015262:Xenobiotics