RCAS1 decidual immunoreactivity during placental abruption: immune cell presence and activity.
OBJECTIVE
RCAS1 is a protein responsible for the suppression of cytotoxic immune response during gestation. The present study evaluates the immunoreactivity level of RCAS1 with respect to immune cell status during placental abruption (PA) and retained placental tissue (RPT).


METHODS
RCAS1, CD3, CD56, CD69 and CD25 immunoreactivity was assessed by immunohistochemistry in 66 decidual samples derived from PA and from RPT.


RESULTS
RCAS1 immunoreactivity was statistically significantly higher in decidual tissue samples derived from patients with RPT than in those derived from patients with PA. A statistically significantly lower number of CD56(+) and CD3(+) cells and immunoreactivity level of CD69 were found in patients with RPT, compared to those with PA.


CONCLUSIONS
Placental abruption seems to be associated with excessive accumulation and activity of CD3(+) and CD56(+) cells in decidua, which processes might, in turn, result from an insufficient RCAS1 decidual level.
Wicherek
Lukasz
L
Department of Gynecology and Oncology, Jagiellonian University, Krakow, Poland. mowicher@cyf-kr.edu.pl
Galazka
Krystyna
K
Lazar
Agata
A
D000037:Abruptio Placentae / Q000276:immunology / Q000378:metabolism*; D000951:Antigens, Neoplasm / Q000378:metabolism*; D003656:Decidua / Q000276:immunology*; D005260:Female; D006801:Humans; D007107:Immune System / Q000166:cytology / Q000378:metabolism*; D018457:Placenta, Retained / Q000276:immunology / Q000378:metabolism; D011247:Pregnancy
D000951:Antigens, Neoplasm; C120762:EBAG9 protein, human