Structurally defined imidazolium-type ionic oligomers as soluble/solid support for peptide synthesis.
Structurally defined ionic liquid-type imidazolium oligomers have been synthesized in multigram scales. These imidazolium salts have been applied to synthesize peptides efficiently in gram scale. The assembly of oligopeptides was conducted in homogeneous solution phase without the need of much excess reagents and capping as in the case of solid-phase peptide synthesis. Importantly, this approach made efficient peptide block couplings possible.
He
Xun
X
Department of Chemistry, McGill University, Montreal, Quebec, Canada.
Chan
Tak Hang
TH
D007093:Imidazoles / Q000737:chemistry*; D007202:Indicators and Reagents; D007536:Isomerism; D055264:Mucin-4; D009077:Mucins / Q000138:chemical synthesis; D009842:Oligopeptides / Q000138:chemical synthesis*; D012996:Solutions; D013818:Thermogravimetry
D007093:Imidazoles; D007202:Indicators and Reagents; D055264:Mucin-4; D009077:Mucins; D009842:Oligopeptides; D012996:Solutions