Diffusion tensor anisotropy in adolescents and adults.
We acquired diffusion tensor images on 33 normal adults aged 22-64 and 15 adolescents aged 14-21. We assessed relative anisotropy in stereotaxically located regions of interest in the internal capsule, corpus callosum, anterior thalamic radiations, frontal anterior fasciculus, fronto-occipital fasciculus, temporal lobe white matter, cingulum bundle, frontal inferior longitudinal fasciculus, frontal superior longitudinal fasciculus, and optic radiations. All of these structures except the optic radiations, corpus callosum, and frontal inferior longitudinal fasciculus exhibited differences in anisotropy between adolescents and adults. Areas with anisotropy increasing with age included the anterior limb of the internal capsule, superior levels of the frontal superior longitudinal fasciculus and the inferior portion of the temporal white matter. Areas with anisotropy decreasing with age included the posterior limb of the internal capsule, anterior thalamic radiations, fronto-occipital fasciculus, anterior portion of the frontal anterior fasciculus, inferior portion of the frontal superior longitudinal fasciculus, cingulum bundle and superior portion of the temporal axis. Sex differences were found in the majority of areas but were most marked in the cingulum bundle and internal capsule. These results suggest continuing white matter development between adolescence and adulthood.
Schneiderman
Jason S
JS
Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA. jason.schneiderman@mssm.edu
Buchsbaum
Monte S
MS
Haznedar
M Mehmet
MM
Hazlett
Erin A
EA
Brickman
Adam M
AM
Shihabuddin
Lina
L
Brand
Jesse G
JG
Torosjan
Yuliya
Y
Newmark
Randall E
RE
Tang
Cheuk
C
Aronowitz
Jonathan
J
Paul-Odouard
Reshmi
R
Byne
William
W
Hof
Patrick R
PR
D000328:Adult; D000375:Aging / Q000502:physiology*; D000704:Analysis of Variance; D016880:Anisotropy; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D007839:Functional Laterality; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D012737:Sex Factors