title: [Heart transplantation].
abstract: Heart transplantation remains the best treatment for terminal heat failure. Ischemic and idiopathic cardiomyopathies are the main indications. Contraindications are due to immunosuppressive treatment and fixed pulmonary hypertension. After clinical evaluation, the patient is put on the waiting list controlled by the French Biomedicine Agency. Acute rejection had decrease due to the improvement of immunosuppressive treatments. The incidence of severe acute rejection is 5%. Chronic rejection is the main cause of morbidity and mortality. The rate at 5 years is about 40-50%. Survival at one year is 80%. The rate of mortality per year is 4%. Survival at 5 and 10 years are respectively 65 and 50%.
authors.affiliation: Institut de cardiologie, groupe hospitalier La Pitié-Salpêtrière, université Pierre-et-Marie-Curie, Paris-6, 75651 Paris 13. alain.pavie@psl.aphp.fr
authors.forename: Alain
authors.initials: A
authors.lastname: Pavie
authors.forename: Nicolas
authors.initials: N
authors.lastname: Bonnet
authors.forename: Pascal
authors.initials: P
authors.lastname: Leprince
authors.forename: Teodoro
authors.initials: T
authors.lastname: Barreda
mesh_terms: D002311:Cardiomyopathy, Dilated / Q000601:surgery; D000075202:Contraindications; D005602:France; D006084:Graft Rejection / Q000517:prevention & control; D006333:Heart Failure / Q000601:surgery; D016027:Heart Transplantation / Q000009:adverse effects / Q000379:methods; D006801:Humans; D006976:Hypertension, Pulmonary / Q000150:complications; D007165:Immunosuppression Therapy / Q000009:adverse effects; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use; D017202:Myocardial Ischemia / Q000601:surgery; D011183:Postoperative Complications; D015996:Survival Rate; D014019:Tissue Donors; D014850:Waiting Lists
chemical_list: D007166:Immunosuppressive Agents