Plasmalogen assembly: a key flavoenzyme.
The structural properties of alkyldihydroxyacetonephosphate synthase (ADPS) described by Razeto et al. (2007) in this issue of Structure provide new insights into how this peroxisomal flavoenzyme catalyzes a nonredox reaction in the conversion of an ester to an ether linkage in plasmologen biosynthesis.
Edmondson
Dale E
DE
D019883:Alkyl and Aryl Transferases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D019943:Amino Acid Substitution; D001665:Binding Sites; D002384:Catalysis; D019281:Dimerization; D005182:Flavin-Adenine Dinucleotide / Q000737:chemistry / Q000378:metabolism; D006639:Histidine / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D020675:Peroxisomes / Q000201:enzymology / Q000378:metabolism; D010649:Phenylalanine / Q000378:metabolism; D010742:Phospholipid Ethers / Q000378:metabolism*; D011485:Protein Binding; D013379:Substrate Specificity
D010742:Phospholipid Ethers; D005182:Flavin-Adenine Dinucleotide; D010649:Phenylalanine; D006639:Histidine; D019883:Alkyl and Aryl Transferases; C019654:alkylglycerone-phosphate synthase