In utero exposure to maternal obesity and diabetes: animal models that identify and characterize implications for future health.
The developed and developing worlds are experiencing an epidemic of obesity and associated predisposition to diabetes. This epidemic places a major drain on health care resources. It is now clear that maternal obesity and gestational diabetes have major adverse effects on the developing fetus that lead to increased neonatal morbidity and mortality, as discussed elsewhere in this issue. Obesity in pregnancy and gestational diabetes represent a special problem, not only as a result of their immediate adverse effects on maternal health and pregnancy outcome, but also because of growing evidence for their persistent and deleterious effects on the developing child.
Nathanielsz
Peter W
PW
Department of Obstetrics & Gynecology, Center for Pregnancy and Newborn Research, The University of Texas of Health Science Center, 7703 Floyd Curl Drive, MSC 7836, San Antonio, TX 78229, USA. nathanielsz@uthscsa.edu
Poston
Lucilla
L
Taylor
Paul D
PD
D000273:Adipose Tissue / Q000196:embryology; D000818:Animals; D001066:Appetite / Q000502:physiology; D016640:Diabetes, Gestational / Q000503:physiopathology*; D004195:Disease Models, Animal; D004198:Disease Susceptibility; D005260:Female; D006321:Heart / Q000503:physiopathology; D006801:Humans; D007328:Insulin / Q000378:metabolism; D007333:Insulin Resistance / Q000502:physiology; D000078790:Insulin Secretion; D039382:Maternal Nutritional Physiological Phenomena; D009043:Motor Activity / Q000502:physiology; D009765:Obesity / Q000503:physiopathology*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects
D007328:Insulin