title: The glutathione thiyl radical does not react with nitrogen monoxide.
abstract: Laser flash photolysis experiments shows that the rate constant for the reaction of the glutathione thiyl radical with nitrogen monoxide to give S-nitrosoglutathione is lower than 2.8+/-0.6 x 10(7)M(-1)s(-1). The conversion of the thiyl radical to its carbon-centred form at 10(3)s(-1) exceeds the formation of S-nitrosoglutathione when physiological concentrations of nitrogen monoxide are taken into account.
authors.affiliation: Laboratory for Inorganic Chemistry, Department of Chemistry and Applied Bioscience, ETH Zurich, Wolfgang-Pauli-Strasse 10, CH-8093 Zurich, Switzerland.
authors.forename: Dustin
authors.initials: D
authors.lastname: Hofstetter
authors.forename: Thomas
authors.initials: T
authors.lastname: Nauser
authors.forename: Willem H
authors.initials: WH
authors.lastname: Koppenol
mesh_terms: D005609:Free Radicals / Q000737:chemistry; D005978:Glutathione / Q000737:chemistry*; D009569:Nitric Oxide / Q000737:chemistry*; D013438:Sulfhydryl Compounds / Q000737:chemistry*
chemical_list: D005609:Free Radicals; D013438:Sulfhydryl Compounds; D009569:Nitric Oxide; D005978:Glutathione