Antidepressant-like effect of hyperfoliatin, a polyisoprenylated phloroglucinol derivative from Hypericum perfoliatum (Clusiaceae) is associated with an inhibition of neuronal monoamines uptake.
This study investigated, in mice, the antidepressant like effect of hyperfoliatin, a prenylated phloroglucinol derivative isolated from the aerial parts of Hypericum perfoliatum, as well as its action on monoaminergic systems. In the forced-swimming test, hyperfoliatin dose-dependently reduced immobility time. Immobility was interpreted as an expression of "behavioural despair", which could be a component of depression syndrome. The effect of hyperfoliatin did not result from the stimulation of animal motor activity. Hyperfoliatin inhibited, in a concentration-dependent manner, the [(3)H]-dopamine, [(3)H]-serotonin and [(3)H]-noradrenaline synaptosomal uptakes, but did not prevent the binding of specific ligands to the monoamine transporters. These data suggest that the antidepressant-like effect of hyperfoliatin on the forced-swimming test is probably associated to monoamine uptake inhibition, due to a mechanism of action different from that of known antidepressants.
do Rego
Jean-Claude
JC
CNRS FRE 2735, Laboratory of Experimental Neuropsychopharmacology, European Institute for Peptide Research (IFRMP 23), Faculty of Medicine and Pharmacy, Institute of Biomedical Research, University of Rouen, France. jean-claude.dorego@univ-rouen.fr
Benkiki
Naïma
N
Chosson
Elizabeth
E
Kabouche
Zahia
Z
Seguin
Elisabeth
E
Costentin
Jean
J
D000818:Animals; D000928:Antidepressive Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D003863:Depression / Q000188:drug therapy*; D004195:Disease Models, Animal; D004298:Dopamine / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D020902:Hypericum / Q000737:chemistry*; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D014179:Neurotransmitter Uptake Inhibitors / Q000008:administration & dosage / Q000494:pharmacology; D009638:Norepinephrine / Q000378:metabolism; D010696:Phloroglucinol / Q000031:analogs & derivatives; D008517:Phytotherapy; D035261:Plant Components, Aerial; D010936:Plant Extracts; D012701:Serotonin / Q000378:metabolism; D013550:Swimming; D014315:Triterpenes / Q000008:administration & dosage / Q000494:pharmacology*
D000928:Antidepressive Agents; D014179:Neurotransmitter Uptake Inhibitors; D010936:Plant Extracts; D014315:Triterpenes; C480308:hyperfoliatin; D012701:Serotonin; D010696:Phloroglucinol; D004298:Dopamine; D009638:Norepinephrine