title: Matrix-producing breast carcinoma: a case report of this rare entity.
abstract: Matrix-producing carcinoma of the breast is very rare with few cases reported in the literature. This entity is characterized by the association of malignant epithelial elements and a mesenchymal component. Therapeutic strategy is not well established and prognostic factors need further research. We report here a case of matrix-producing carcinoma in a 46-years-old woman who presented with a large lump in her left breast. A core biopsy concluded to an invasive carcinoma but neoadjuvant chemotherapy was not helpful. Diagnosis of matrix-producing carcinoma was done on the lumpectomy specimen after excision of the fast-growing mass. Immunophenotypic profile was very suggestive showing tumoral cells positivity for cytokeratins, epithelial membran antigen and S-100 protein. One year later, the patient developed lung metastases.
authors.affiliation: Department of Immuno-Histo-Cytology, Salah Azaiz Institut, Tunis, Tunisia. maamourifathia@yahoo.fr
authors.forename: F
authors.initials: F
authors.lastname: Maamouri
authors.forename: A
authors.initials: A
authors.lastname: Gamoudi
authors.forename: N B
authors.initials: NB
authors.lastname: Mna
authors.forename: J B
authors.initials: JB
authors.lastname: Hassouna
authors.forename: H
authors.initials: H
authors.lastname: Boussen-
authors.forename: May A
authors.initials: MA
authors.lastname: El
mesh_terms: D001943:Breast Neoplasms / Q000473:pathology*; D002277:Carcinoma / Q000473:pathology*; D005260:Female; D006801:Humans; D008875:Middle Aged