title: STAT1 and STAT3 as intracellular regulators of vascular remodeling.
abstract: The roles of signal transducers and activators of transcription (STAT) proteins are widely discussed in the pathogenesis of cardiovascular diseases. It is highly probable that STAT1 and STAT3 are activated during proliferation and inflammation inside atheromatous plaques. Luminal surfaces of endothelium become thrombogenic because of STAT1-dependent induction of MHC II and STAT3-regulated recruitment of phospholipase A2. As with STAT1, STAT3 seems to mediate stimulation of vascular wall cells by VEGF, HGF, and Ang II. STAT3 can contribute to counteracting apoptosis by eventual cooperation with c-fos and the bcl-xl gene. As pharmacological agents called statins are reported to regulate activities of STAT proteins, these signal messenger proteins could serve as targets for anti-atherogenic therapy. We attempted to review the role of STAT1 and STAT3 proteins in vascular remodeling.
authors.affiliation: Department of Pathology, Waszyngtona St 13, 15-269 Białystok, Collegium Pathologicum, Medical University of Bialystok, Poland.
authors.forename: Andrzej
authors.initials: A
authors.lastname: Wincewicz
authors.forename: Mariola
authors.initials: M
authors.lastname: Sulkowska
authors.forename: Ryszard
authors.initials: R
authors.lastname: Rutkowski
authors.forename: Stanislaw
authors.initials: S
authors.lastname: Sulkowski
authors.forename: Boguslaw
authors.initials: B
authors.lastname: Musiatowicz
authors.forename: Tomasz
authors.initials: T
authors.lastname: Hirnle
authors.forename: Waldemar
authors.initials: W
authors.lastname: Famulski
authors.forename: Mariusz
authors.initials: M
authors.lastname: Koda
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Sokol
authors.forename: Przemyslaw
authors.initials: P
authors.lastname: Szarejko