title: What difference does it make? The calculation of QALY gains from health profiles using patient and general population values.
abstract: OBJECTIVE
  To compare the Quality-Adjusted Life Year (QALY) values produced from a direct health profile QALY calculation method, using patient values, with those derived from a conventional QALY calculation method, using general population values.
  
  
  METHODS
  Comparison of QALY values generated from patient valuations of health profiles, using a chained version of the Time Trade-Off method, with QALY values derived from a conventional QALY calculation method, using general population values of EQ-5D states, an observational survey of MS patients, and a randomized controlled trial.
  
  
  RESULTS
  Using patient valuations of health profiles, QALY values of treatment and placebo were 2.610 and 2.568, respectively, generating a gain of 0.042. The conventional QALY method gave values of 2.042 versus 1.998, producing a gain of 0.044. These findings were generally robust under sensitivity analyses.
  
  
  CONCLUSIONS
  QALY values were dependent on the calculation method used, but QALY gains were similar between methods. QALY values from the conventional QALY calculation method appeared robust to most changes in the assumptions used to derive values. The direct health profile QALY method was however more able to account for heterogeneity in preferences.
authors.affiliation: Health Economics Research Unit, Institute of Applied Health Sciences, Foresterhill, University of Aberdeen, Aberdeen AB25 2ZD, UK. p.mcnamee@abdn.ac.uk
authors.forename: Paul
authors.initials: P
authors.lastname: McNamee
mesh_terms: D003362:Cost-Benefit Analysis; D006291:Health Policy; D006304:Health Status; D006306:Health Surveys; D006801:Humans; D016899:Interferon-beta / Q000627:therapeutic use; D009103:Multiple Sclerosis / Q000188:drug therapy; D010361:Patients / Q000523:psychology*; D015990:Placebo Effect; D019057:Quality-Adjusted Life Years; D012945:Social Values
chemical_list: D016899:Interferon-beta