Endoscopic submucosal dissection with insulated-tip knife for large mucosal early gastric cancer: a feasibility study (with videos).
BACKGROUND
According to clinicopathologic studies, differentiated-type mucosal early gastric cancers without ulcer or ulcer scar have little risk of lymph-node metastasis, irrespective of tumor size. However, patients with large mucosal early gastric cancer have been subjected to surgery because conventional EMR methods could not resect large tumors en bloc.


OBJECTIVE
To evaluate the feasibility and the efficacy of endoscopic submucosal dissection for treatment of early gastric cancers larger than 3 cm in diameter.


METHODS
Case series study.


METHODS
Referral cancer center.


METHODS
A total of 30 consecutive patients were enrolled with the following characteristics: diagnosis of differentiated-type early gastric cancer larger than 3 cm, lack of ulcerative change, no endoscopic evidence for submucosal invasion, and no evidence of lymph-node or distant metastasis (22 men and 8 women; median age, 69 years; median tumor size, 40 mm).


METHODS
Tumors were resected by endoscopic submucosal dissection with an insulated-tip knife.


METHODS
Complete resection, complication rate, and operation time.


RESULTS
Complete resection was obtained in 23 of 30 cases (77%). Complications included hemorrhage (n=4), perforation (n=1), and pyloric stenosis (n=1), but no severe complications occurred that required surgery or that led to major morbidity. Complete resection and complication rates improved in the last 10 cases (90% and 0%, respectively), though operation time was not shortened.


CONCLUSIONS
Small sample size and lack of controls.


CONCLUSIONS
Endoscopic submucosal dissection when using the insulated-tip knife is feasible and efficacious for selected patients with mucosal early gastric cancer larger than 3 cm.
Takeuchi
Yoji
Y
Department of Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan.
Uedo
Noriya
N
Iishi
Hiroyasu
H
Yamamoto
Sachiko
S
Yamamoto
Shunsuke
S
Yamada
Takuya
T
Higashino
Koji
K
Ishihara
Ryu
R
Tatsuta
Masaharu
M
Ishiguro
Shingo
S
D000368:Aged; D002277:Carcinoma / Q000473:pathology / Q000601:surgery*; D004210:Dissection / Q000295:instrumentation*; D005240:Feasibility Studies; D005260:Female; D005500:Follow-Up Studies; D005753:Gastric Mucosa / Q000601:surgery*; D005773:Gastroscopy; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013274:Stomach Neoplasms / Q000473:pathology / Q000601:surgery*; D016896:Treatment Outcome