title: Effects of a dairy product fortified with multiple micronutrients and omega-3 fatty acids on birth weight and gestation duration in pregnant Chilean women.
abstract: OBJECTIVE
  To test the hypothesis that maternal food fortification with omega-3 fatty acids and multiple micronutrients increases birth weight and gestation duration, as primary outcomes.
  
  
  METHODS
  Non-blinded, randomised controlled study.
  
  
  METHODS
  Pregnant women received powdered milk during their health check-ups at 19 antenatal clinics and delivered at two maternity hospitals in Santiago, Chile.
  
  
  METHODS
  Pregnant women were assigned to receive regular powdered milk (n = 477) or a milk product fortified with multiple micronutrients and omega-3 fatty acids (n = 495).
  
  
  RESULTS
  Intention-to-treat analysis showed that mean birth weight was higher in the intervention group than in controls (65.4 g difference, 95% confidence interval (CI) 5-126 g; P = 0.03) and the incidence of very preterm birth (0.80 just for mean birth weight and birth length in the on-treatment analysis; birth length in that analysis had a difference of 0.57 cm (95% CI 0.19-0.96 cm; P = 0.003).
  
  
  CONCLUSIONS
  The new intervention resulted in increased mean birth weight. Associations with gestation duration and most secondary outcomes need a larger sample size for confirmation.
authors.affiliation: 1Department of Public Health, School of Medicine, Faculty of Medicine, Pontificia Universidad Catolica de Chile, Marcoleta 434, Santiago, Chile. mardones@med.puc.cl
authors.forename: Francisco
authors.initials: F
authors.lastname: Mardones
authors.forename: Maria-Teresa
authors.initials: MT
authors.lastname: Urrutia
authors.forename: Luis
authors.initials: L
authors.lastname: Villarroel
authors.forename: Alonso
authors.initials: A
authors.lastname: Rioseco
authors.forename: Oscar
authors.initials: O
authors.lastname: Castillo
authors.forename: Jaime
authors.initials: J
authors.lastname: Rozowski
authors.forename: Jose-Luis
authors.initials: JL
authors.lastname: Tapia
authors.forename: Gabriel
authors.initials: G
authors.lastname: Bastias
authors.forename: Jorge
authors.initials: J
authors.lastname: Bacallao
authors.forename: Ivan
authors.initials: I
authors.lastname: Rojas
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D001724:Birth Weight / Q000187:drug effects*; D002677:Chile / Q000453:epidemiology; D003611:Dairy Products; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage*; D005260:Female; D005527:Food, Fortified; D005865:Gestational Age; D006405:Hematology; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D016014:Linear Models; D008297:Male; D018977:Micronutrients / Q000008:administration & dosage*; D008892:Milk; D011225:Pre-Eclampsia / Q000175:diagnosis; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000453:epidemiology; D039401:Prenatal Nutritional Physiological Phenomena
chemical_list: D015525:Fatty Acids, Omega-3; D018977:Micronutrients