title: Models of active transport of neurotransmitters in synaptic vesicles.
abstract: Models of the active transport of neurotransmitters in synaptic vesicles were constructed. The models were used to determine the resting potential at membranes of synaptic vesicles: 40mV (monoamines and acetylcholine) and -40mV (glutamate). The potential at the membrane of a synaptic vesicle was almost absent for the transport of GABA and glycine. The neurotransmitter concentration of a cell was 0.1-18mM at the concentration of neurotransmitters in a vesicle equal to 0.5M. This result is in qualitative agreement with the relevant experimental data.
authors.affiliation: Molecular Physics Chair, Ural State Technical University, 19 Mira Street, 620002 Yekaterinburg, Russia. mav@dpt.ustu.ru
authors.forename: Alexey V
authors.initials: AV
authors.lastname: Melkikh
authors.forename: Vladimir D
authors.initials: VD
authors.lastname: Seleznev
mesh_terms: D000818:Animals; D001693:Biological Transport, Active / Q000502:physiology*; D006801:Humans; D008564:Membrane Potentials; D008959:Models, Neurological; D018377:Neurotransmitter Agents / Q000378:metabolism*; D009435:Synaptic Transmission / Q000502:physiology; D013572:Synaptic Vesicles / Q000378:metabolism*
chemical_list: D018377:Neurotransmitter Agents