Preparation and characterization of nano-hydroxyapatite/chitosan/konjac glucomannan composite.
Nano-hydroxyapatite (n-HA)/chitosan (CS)/konjac glucomannan (KGM) composite was prepared by coprecipitation method and investigated by thermal gravitivity/differentiate thermal analysis, Fourier transform infrared spectroscopy, X-ray diffraction, inductively coupled plasma emission spectroscopy, scanning electron microscopy, and energy dispersive X-ray analyzer. The analyses showed that the three phases of n-HA, CS, and KGM combined closely to each other. Further, in vitro tests were conducted to investigate the degradation and bioactivity of the composite. During immersion in simulated body fluid (SBF), pores appeared and a new substance containing Ca and P formed on the surface of the composite. Also, the concentration of Ca and P in SBF changed and weight loss of the composite was observed during time. The composite revealed a high degradation in SBF. Evidently, the new composite has a potential to be used as a carrier of implantable drug delivery system. The biodegradation rate and route could be different from CS and KGM, which will provide an opportunity to control the degradation rate or drug releasing rate by simply adjusting the ratio of CS and KGM.
Zhou
Gang
G
Research Center for Nano-Biomaterials, Analytical and Testing Center, Sichuan University, Chengdu 610064, China.|College of Chemistry, Sichuan University, Chengdu 610064, China.
Li
Yubao
Y
Research Center for Nano-Biomaterials, Analytical and Testing Center, Sichuan University, Chengdu 610064, China.
Zhang
Li
L
Research Center for Nano-Biomaterials, Analytical and Testing Center, Sichuan University, Chengdu 610064, China.
Zuo
Yi
Y
Research Center for Nano-Biomaterials, Analytical and Testing Center, Sichuan University, Chengdu 610064, China.
Jansen
John A
JA
Department of Periodontology and Biomaterials, Radboud University Nijmegen Medical Center, Nijimegen, The Netherlands.
D002240:Carbohydrate Sequence; D048271:Chitosan / Q000737:chemistry*; D017886:Durapatite / Q000737:chemistry*; D008351:Mannans / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D008969:Molecular Sequence Data; D053758:Nanoparticles; D017550:Spectroscopy, Fourier Transform Infrared; D014961:X-Ray Diffraction
D008351:Mannans; C022901:(1-6)-alpha-glucomannan; D048271:Chitosan; D017886:Durapatite