Slipped strand DNA structures.
Slipped strand DNA structures are formed when complementary strands comprising direct repeats pair in a misaligned, or slipped, fashion along the DNA helix axis. Although slipped strand DNA may form in almost any direct repeat, to date, these structures have only been detected in short DNA repeats, termed unstable DNA repeats, in which expansion is associated with many neurodegenerative diseases. This alternative DNA structure, or a similar slipped intermediate DNA that may form during DNA replication or repair, may be a causative factor in the instability of the DNA sequences that can form these structures.
Sinden
Richard R
RR
Laboratory of DNA Structure and Mutagenesis, Department of Biological Sciences, Florida Institute of Technology, Melbourne, FL 32901-6975, USA. rsinden@fit.edu
Pytlos-Sinden
Malgorzata J
MJ
Potaman
Vladimir N
VN
D004247:DNA / Q000737:chemistry*; D004260:DNA Repair; D045643:DNA Repair Enzymes / Q000502:physiology; D042622:DNA Repeat Expansion; D004261:DNA Replication / Q000502:physiology; D004259:DNA-Directed DNA Polymerase / Q000502:physiology; D042822:Genomic Instability; D008957:Models, Genetic; D009690:Nucleic Acid Conformation; D012091:Repetitive Sequences, Nucleic Acid
D004247:DNA; D004259:DNA-Directed DNA Polymerase; D045643:DNA Repair Enzymes