Nodular glomerulosclerosis in the nondiabetic smoker.
Emerging evidence supports that the entity known as idiopathic nodular glomerulosclerosis is not idiopathic. A strong causative association with longstanding cigarette smoking and hypertension has been identified. Morphologically, smoking-associated nodular glomerulosclerosis closely resembles diabetic nephropathy. The potential roles of advanced glycation end products, oxidative stress, angiogenesis, and hemodynamic perturbations are explored.
Nasr
Samih H
SH
Department of Pathology, Columbia University, College of Physicians & Surgeons, New York, NY 10032, USA.
D'Agati
Vivette D
VD
D003928:Diabetic Nephropathies / Q000209:etiology*; D006801:Humans; D012907:Smoking / Q000009:adverse effects*