title: Halogen dance reactions--a review.
abstract: Halogen Dance (HD) reactions are a useful tool for synthetic chemists as they enable access to positions in aromatic and heteroaromatic systems for subsequent functionalization which are often difficult to address by other methods, hence, allowing entry to versatile scaffolds. While the method can be extremely useful, this transformation is often neglected upon designing synthetic sequences. This may be largely attributed to the lack of comprehensive reference works covering the general principles and outlining the versatility and limitations of the technique. The following review tries to present HD reactions in a clear and concise manner in order to convince more chemists of its advantages. It covers the field of HD reactions from their first observation in 1951 until the present. The important contributions leading to the elucidation of the mechanism are briefly outlined followed by a detailed mechanistic section and a discussion of factors which influence HD reactions. Finally, an overview of HD reactions on various carbocyclic and heterocyclic ring systems and its applications in the synthesis of complex compounds is given.
authors.affiliation: Institute of Applied Synthetic Chemistry, Vienna University of Technology, Getreidemarkt 9/163-OC, 1060 Vienna, Austria.
authors.forename: Michael
authors.initials: M
authors.lastname: Schnürch
authors.forename: Markus
authors.initials: M
authors.lastname: Spina
authors.forename: Ather Farooq
authors.initials: AF
authors.lastname: Khan
authors.forename: Marko D
authors.initials: MD
authors.lastname: Mihovilovic
authors.forename: Peter
authors.initials: P
authors.lastname: Stanetty