Botulinum toxin in the treatment of tremors, dystonias, sialorrhea and other symptoms associated with Parkinson's disease.
Botulinum toxins are an effective treatment modality for a growing number of neurologic conditions. Although there has been varied interest and success in their use, they have been studied for a variety of conditions associated with Parkinson's disease. Conditions reviewed in this paper include hand and jaw tremor, dystonia, blepharospasm and apraxia of eyelid opening, bruxism, camptocormia, freezing of gait, sialorrhea and constipation. We will make comments when applicable on our unique experience with botulinum toxin in these conditions. Other conditions associated with Parkinson's disease, which will not be reviewed here, but may benefit from botulinum toxin treatment include anterocollis (also known as dropped head syndrome), hyperhidrosis, seborrhea and overactive bladder.
Sheffield
James K
JK
Department of Neurology, Baylor College of Medicine, Parkinson's Disease Center & Movement Disorders Clinic, 6550 Fannin, Suite 1801, Houston, TX 77030, USA. jksheffi@bcm.edu
Jankovic
Joseph
J
D018687:Antidepressive Agents, Second-Generation / Q000008:administration & dosage; D001905:Botulinum Toxins / Q000008:administration & dosage*; D002986:Clinical Trials as Topic / Q000639:trends; D004305:Dose-Response Relationship, Drug; D004421:Dystonia / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D010300:Parkinson Disease / Q000150:complications / Q000188:drug therapy*; D010818:Practice Patterns, Physicians' / Q000639:trends; D012798:Sialorrhea / Q000188:drug therapy* / Q000209:etiology; D016896:Treatment Outcome; D014202:Tremor / Q000188:drug therapy* / Q000209:etiology
D018687:Antidepressive Agents, Second-Generation; D001905:Botulinum Toxins