title: Beta-catenin and ZO-1: shuttle molecules involved in tumor invasion-associated epithelial-mesenchymal transition processes.
abstract: The cytoplasmic/nuclear relocalization of beta-catenin and ZO-1 from the adherens and tight junctions are common processes of the epithelial-mesenchymal transition (EMT) associated with tumor invasion. Data are now accumulating to demonstrate that these molecules, which shuttle between the plasma membrane and the nucleus or the cytosol, are involved in signaling pathways, and contribute to the regulation of genes such as vimentin or matrix metalloproteinase-14 which are turned on during EMT.
authors.affiliation: INSERM UMRS 514, Laboratory of Histology, IFR 53, CHU Maison Blanche, Reims, France.
authors.forename: Myriam
authors.initials: M
authors.lastname: Polette
authors.forename: Mélanie
authors.initials: M
authors.lastname: Mestdagt
authors.forename: Sandrine
authors.initials: S
authors.lastname: Bindels
authors.forename: Béatrice
authors.initials: B
authors.lastname: Nawrocki-Raby
authors.forename: Walter
authors.initials: W
authors.lastname: Hunziker
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Foidart
authors.forename: Philippe
authors.initials: P
authors.lastname: Birembaut
authors.forename: Christine
authors.initials: C
authors.lastname: Gilles
mesh_terms: D004847:Epithelial Cells / Q000166:cytology / Q000378:metabolism; D004848:Epithelium / Q000378:metabolism*; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism*; D008648:Mesoderm / Q000166:cytology / Q000378:metabolism*; D008954:Models, Biological; D009361:Neoplasm Invasiveness; D010750:Phosphoproteins / Q000235:genetics / Q000378:metabolism*; D062826:Zonula Occludens-1 Protein; D051176:beta Catenin / Q000235:genetics / Q000378:metabolism*
chemical_list: D008565:Membrane Proteins; D010750:Phosphoproteins; D062826:Zonula Occludens-1 Protein; D051176:beta Catenin