Diagnosis and treatment for graft-versus-host disease after liver transplantation: two case reports.
OBJECTIVE
The diagnosis and treatments were of 2 cases of graft-versus-host disease (GVHD) after liver transplantation are presented herein.


METHODS
The 2 cases were diagnosed at 24 and 32 days after liver transplantation, respectively. Fever, diarrhea, skin rash, and leukopenia were symptoms in both of them. They were treated with methylprednisolone (0.5 g/d, for 3 days), G-CSF, and GM-CSF. The dose of CsA was decreased in 1 of them.


RESULTS
One patient died of cerebral hemorrhage at 31 days after transplantation. The other 1 responded well to the methylprednisolone and the skin rash disappeared within 1 week after the treatment. He was discharged 50 days after transplantation.


CONCLUSIONS
Clinicians should be familiar with the risk factors, signs, and symptoms associated with GVHD after liver transplantation. Corticosteroids are the choice of treatment for GVHD after liver transplantation. Immunosuppressive agents should be decreased when GVHD is diagnosed.
Wang
B
B
Department of Hepatobiliary Surgery, First Hospital of Xian Jiaotong University, 1 Jiankang Road, Xi'an, Shaanxi Province 710061, China. smilebird75@hotmail.com
Lu
Y
Y
Yu
L
L
Liu
C
C
Wu
Z
Z
Liu
X
X
D006086:Graft vs Host Disease / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D016031:Liver Transplantation / Q000009:adverse effects / Q000276:immunology*; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged; D016896:Treatment Outcome
D007166:Immunosuppressive Agents; D008775:Methylprednisolone