[Progress in research on oocytes parthenogenetic activation].
Parthenogenetic activation is a procedure that an oocyte at meiosis II stage is activated into mitosis by some chemical or physical stimulation other than a sperm and the embryo is formed in the absence of any contribution from a male gamete. The activation of oocyte is the result of calcium ion oscillations and deactivation of some cytokines such as maturation promoting factor, mitogen-activated protein kinase and cytostatic factor. Parthenogenetic activation is artificially induced by various kinds of physical and/or chemical methods. The main activation method of human oocyte is chemical methods. The rates of activation and cleavage depend on the age, origin,and culture conditions of the oocyte.
Peng
Mei-lian
ML
The Affiliated Obstetrics and Gynecological Hospital, College of Medicine, Zhejiang University, Hangzhou 310006, China.
Huang
He-feng
HF
Jin
Fan
F
D000225:Adenine / Q000031:analogs & derivatives / Q000494:pharmacology; D000818:Animals; D002118:Calcium / Q000378:metabolism; D003513:Cycloheximide / Q000494:pharmacology*; D016207:Cytokines / Q000378:metabolism; D005260:Female; D006801:Humans; D009865:Oocytes / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D010312:Parthenogenesis / Q000187:drug effects*
D016207:Cytokines; C001020:N(6),N(6)-dimethyladenine; D003513:Cycloheximide; D000225:Adenine; D002118:Calcium