Effect of simvastatin on fracture healing--an experimental study.
Left femur was osteotomized and fixed with K wire in 21 rabbits. One group was fed simvastatin (120 mg/kg body wt/day) orally, whereas another group without medication served as control. Both groups were assessed radiologically, morphologically, histologically and biomechanically at 4, 8 and 12 weeks. An analysis of various parameters of study showed that simvastatin treated group had improved bone healing at 4 and 8 weeks of follow up, however, the difference was not significant statistically at 12 weeks. So it is concluded that Simvastatin favourably hastened the process of fracture healing in the rabbits at earlier phases.
Saraf
S K
SK
Department of Orthopaedics, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221 005, India. sksaraf36@hotmail.com
Singh
Ajit
A
Garbyal
R S
RS
Singh
Vakil
V
D000818:Animals; D001862:Bone Resorption / Q000517:prevention & control; D002146:Bony Callus / Q000000981:diagnostic imaging / Q000187:drug effects; D005269:Femur / Q000000981:diagnostic imaging / Q000293:injuries*; D017102:Fracture Healing / Q000187:drug effects*; D050723:Fractures, Bone / Q000000981:diagnostic imaging / Q000188:drug therapy*; D011817:Rabbits; D011859:Radiography; D019821:Simvastatin / Q000494:pharmacology* / Q000627:therapeutic use*; D013314:Stress, Mechanical; D013997:Time Factors
D019821:Simvastatin