Estrogen and the endometrium: lessons learned from gene expression profiling in rodents and human.
To date, research into the biological processes and molecular mechanisms associated with endometrial receptivity and embryo implantation has been a focus of attention, whereas the complex events that occur in the human endometrium during the menstrual and proliferative phase under the influence of estrogen have received little attention. The objective of this review is to provide an update of our current understanding of the actions of estrogen on both human and rodent endometrium, with special emphasis on the regulation of uterine growth and cell proliferation, and the value of global gene expression analysis, in increasing understanding of these processes.
Groothuis
P G
PG
Research Institute GROW, University Hospital Maastricht/University Maastricht, Maastricht, The Netherlands.
Dassen
H H N M
HH
Romano
A
A
Punyadeera
C
C
D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D004717:Endometrium / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism*; D004967:Estrogens / Q000235:genetics / Q000494:pharmacology* / Q000502:physiology; D005260:Female; D015870:Gene Expression / Q000187:drug effects*; D020869:Gene Expression Profiling; D015894:Genome, Human; D006801:Humans; D008597:Menstrual Cycle / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D015398:Signal Transduction / Q000187:drug effects / Q000235:genetics; D014599:Uterus / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism
D004967:Estrogens