[Effects of estrogen in the CNS].
The data of modern experimental and clinical researches of a estrogen role in pathogenesis of cognitive disorders are analyzed. The estrogen effects on receptor and postreceptor molecular-cellular level, and also its opportunity of cross-talk interaction with various neurotransmitters playing the role in mental functions are described. The data of the estrogen role during cellular differentiation, synaptic neuroplasticity and apoptoz are descibed. In comparative aspect influence [cyrillic word: see text] on training and memory, uneasiness and depression in experiments and in clinic is discussed. The principles of pharmacocorrection of the psycho-neurologic disorders caused by dysfunction of hypohysis-ovary of system, and also an opportunity of the combined application of estrogen and neurotropic drug are considered.
Fedotova
Iu O
IuO
Sapronov
N S
NS
D000701:Analgesics, Opioid / Q000378:metabolism; D000818:Animals; D002490:Central Nervous System / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D003071:Cognition / Q000187:drug effects*; D004967:Estrogens / Q000378:metabolism / Q000494:pharmacology / Q000502:physiology*; D006801:Humans; D001523:Mental Disorders / Q000188:drug therapy / Q000378:metabolism; D009473:Neuronal Plasticity / Q000187:drug effects; D018696:Neuroprotective Agents / Q000494:pharmacology; D051381:Rats; D011960:Receptors, Estrogen / Q000378:metabolism / Q000502:physiology; D013569:Synapses / Q000187:drug effects / Q000502:physiology*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D000701:Analgesics, Opioid; D004967:Estrogens; D018696:Neuroprotective Agents; D011960:Receptors, Estrogen; D005680:gamma-Aminobutyric Acid