Guanylin peptides and colorectal cancer (CRC).
Agonists of guanylyl-C receptor, such as guanylin/uroguanylin, are correlated not only with the intestinal cell epithelial physiology but also with the colorectal cancer tumorigenesis. Activation of the second intracellular messenger cyclic guanosine monophosphate by guanylyl cyclase-C receptor results in a complex intracellular signalling cascade involving the phosphodiesterase, the ion channels and the protein kinase. After an analytical review of relevant new knowledge, new diagnostic and therapeutic approaches for colorectal cancer are discussed.
Camici
Marcello
M
Internal Medicine Department, University of Pisa, Via Roma 67, 56126 Pisa, Italy. m.camici@med.unipi.it
D000818:Animals; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000188:drug therapy*; D006152:Cyclic GMP / Q000378:metabolism; D005768:Gastrointestinal Hormones / Q000494:pharmacology* / Q000627:therapeutic use; D006162:Guanylate Cyclase; D006801:Humans; D007473:Ion Channels / Q000378:metabolism; D045265:Natriuretic Peptides / Q000494:pharmacology* / Q000627:therapeutic use; D010727:Phosphoric Diester Hydrolases / Q000378:metabolism; D011494:Protein Kinases / Q000378:metabolism; D000074261:Receptors, Enterotoxin; D050705:Receptors, Guanylate Cyclase-Coupled; D018000:Receptors, Peptide / Q000819:agonists*; D015398:Signal Transduction
D005768:Gastrointestinal Hormones; D007473:Ion Channels; D045265:Natriuretic Peptides; D018000:Receptors, Peptide; C072685:guanylin; C084362:uroguanylin; D011494:Protein Kinases; D010727:Phosphoric Diester Hydrolases; D006162:Guanylate Cyclase; D000074261:Receptors, Enterotoxin; D050705:Receptors, Guanylate Cyclase-Coupled; D006152:Cyclic GMP