title: Monosomy 7 with severe myelodysplasia developing during imatinib treatment of Philadelphia-positive chronic myeloid leukemia: two cases with a different outcome.
abstract: Chromosomal abnormalities in Ph-negative metaphases from patients with chronic myeloid leukemia (CML) treated with imatinib have been described in some cases. Trisomy 8 is the most frequent, but monosomy 7 has also been described. However, the association of these chromosomal alterations with myelodysplasia has been scarcely reported. We report the appearance of monosomy 7 in Ph-negative cells, associated with severe dysplasia, in two patients with CML treated with imatinib, with a different outcome: one with a transient evolution and the other evolving to acute myeloid leukemia.
authors.affiliation: Servei d'Hematologia, Institut Català d'Oncologia, Hospital Germans Trias i Pujol, Badalona, Barcelona. jtnavarr@ico.scs.es
authors.forename: José-Tomás
authors.initials: JT
authors.lastname: Navarro
authors.forename: Evarist
authors.initials: E
authors.lastname: Feliu
authors.forename: Javier
authors.initials: J
authors.lastname: Grau
authors.forename: Blanca
authors.initials: B
authors.lastname: Espinet
authors.forename: Dolors
authors.initials: D
authors.lastname: Colomer
authors.forename: Josep-Maria
authors.initials: JM
authors.lastname: Ribera
authors.forename: Albert
authors.initials: A
authors.lastname: Oriol
authors.forename: Isabel
authors.initials: I
authors.lastname: Granada
authors.forename: Jordi
authors.initials: J
authors.lastname: Juncà
authors.forename: Fuensanta
authors.initials: F
authors.lastname: Millá
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001549:Benzamides; D002897:Chromosomes, Human, Pair 7; D018450:Disease Progression; D017809:Fatal Outcome; D006801:Humans; D000068877:Imatinib Mesylate; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000175:diagnosis / Q000188:drug therapy* / Q000235:genetics*; D054438:Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009006:Monosomy / Q000235:genetics* / Q000276:immunology; D009190:Myelodysplastic Syndromes / Q000235:genetics*; D010879:Piperazines / Q000627:therapeutic use*; D011743:Pyrimidines / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D001549:Benzamides; D010879:Piperazines; D011743:Pyrimidines; D000068877:Imatinib Mesylate