Neurocognitive dysfunction post-cardiac surgery and the neuroprotective effects of erythropoietin.
Neurocognitive dysfunction is a common postoperative complication exacerbated by cardiopulmonary bypass triggering a systemic inflammatory response. This clinical column focuses on the up-regulation of endogenous erythropoietin related to neurological inflammation and the use of recombinant erythropoietin as a neuroprotective pharmacotherapeutic agent.
Bhimji
Zahraa
Z
Caritas Health Group, Edmonton, AB. C/O Nasreen Bhimji, Public Health Division, Office of MOH, Suite 300, 10216, 124 Street, Edmonton, AB T5N 4A3. zbhimji@gmail.com
Estabrooks
Lorna
L
Price
Paula M
PM
D006348:Cardiac Surgical Procedures / Q000009:adverse effects*; D003072:Cognition Disorders / Q000209:etiology / Q000517:prevention & control*; D004921:Erythropoietin / Q000378:metabolism / Q000627:therapeutic use*; D006397:Hematinics / Q000627:therapeutic use*; D006801:Humans; D000860:Hypoxia / Q000378:metabolism / Q000503:physiopathology; D007249:Inflammation / Q000378:metabolism / Q000503:physiopathology; D011994:Recombinant Proteins
D006397:Hematinics; D011994:Recombinant Proteins; D004921:Erythropoietin