title: How to calculate the quantity of CD34+ cells infused? A single center cohort study based on actual, ideal or adjusted ideal body weight.
abstract: Transplant physicians are generally using the recipient's actual body weight (ABW) for the calculation of the content of CD34+ cells in the harvest material in hematopoietic stem cell transplantation (HSCT). As a reference center performing both the stem cell collection and HSCTs, we aimed to evaluate whether there were any differences for neutrophil recovery by calculating the CD34+ cell content in the graft according to actual, ideal (IBW) or adjusted IBW (AIBW) of the recipients in both autologous (n=148) and allogeneic stem cell collection setting (n=234). We observed a negative correlation between the neutrophil recovery and the cell doses infused as to each of these BWs in the allo-HSCT group, but not in the auto-HSCT group. This negative correlation was stronger for IBW and AIBW rather than for ABW in allo-HSCT group. In addition, calculations for both IBW and AIBW in autologous and allogeneic transplants revealed a significant difference in comparison to ABW for different cut-off values of infused CD34+ cells. Consequently, we suggested that both IBW and AIBW based calculations of CD34+ cells infused are better predictors of neutrophil recovery in comparison to ABW in allo-HSCT. We were not able to show this impact in autologous transplants.
authors.affiliation: Ankara University, Faculty of Medicine, Department of Hematology, Hemapheresis and Blood Bank, Cebeci Kampüsü, 06590 Dikimevi, Ankara, Turkey. topcuogl@medicine.ankara.edu.tr
authors.forename: Pervin
authors.initials: P
authors.lastname: Topcuoglu
authors.forename: Ender
authors.initials: E
authors.lastname: Akcaglayan Soydan
authors.forename: Fuat
authors.initials: F
authors.lastname: Ekiz
authors.forename: Erol
authors.initials: E
authors.lastname: Ayyildiz
authors.forename: Klara
authors.initials: K
authors.lastname: Dalva
authors.forename: Muhit
authors.initials: M
authors.lastname: Ozcan
authors.forename: Onder
authors.initials: O
authors.lastname: Arslan
authors.forename: Mutlu
authors.initials: M
authors.lastname: Arat
authors.forename: Osman
authors.initials: O
authors.lastname: Ilhan
mesh_terms: D000293:Adolescent; D000328:Adult; D018952:Antigens, CD34; D001835:Body Weight; D002452:Cell Count / Q000379:methods*; D015331:Cohort Studies; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000592:standards*; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000166:cytology; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous; D055815:Young Adult
chemical_list: D018952:Antigens, CD34