title: EbpR is important for biofilm formation by activating expression of the endocarditis and biofilm-associated pilus operon (ebpABC) of Enterococcus faecalis OG1RF.
abstract: We identify ef1090 (renamed ebpR) and show its importance for the transcriptional regulation of expression of the Enterococcus faecalis pilus operon, ebpABC. An ebpR deletion (DeltaebpR) mutant was found to have reduced ebpABC expression with loss of pilus production and a defect in primary adherence with, as a consequence, reduced biofilm formation.
authors.affiliation: Division of Infectious Diseases, Department of Medicine, Center for the Study of Emerging and Re-emerging Pathogens, MSB 2.112, University of Texas Medical School, 6431 Fannin St., Houston, TX 77030, USA.
authors.forename: Agathe
authors.initials: A
authors.lastname: Bourgogne
authors.forename: Kavindra V
authors.initials: KV
authors.lastname: Singh
authors.forename: Kristina A
authors.initials: KA
authors.lastname: Fox
authors.forename: Kathryn J
authors.initials: KJ
authors.lastname: Pflughoeft
authors.forename: Barbara E
authors.initials: BE
authors.lastname: Murray
authors.forename: Danielle A
authors.initials: DA
authors.lastname: Garsin
mesh_terms: D001422:Bacterial Adhesion / Q000235:genetics / Q000502:physiology; D001426:Bacterial Proteins / Q000235:genetics / Q000502:physiology*; D018441:Biofilms / Q000254:growth & development*; D013293:Enterococcus faecalis / Q000235:genetics / Q000502:physiology*; D010861:Fimbriae, Bacterial / Q000235:genetics*; D017353:Gene Deletion; D015964:Gene Expression Regulation, Bacterial; D009876:Operon; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology*
chemical_list: D001426:Bacterial Proteins; D014157:Transcription Factors