[Protective effect of renshen yangrong decoction on membrane fluidity of mitochondrion in brain and liver of subacute senile mice].
OBJECTIVE
To study the effect of Renshen Yangrong decoction (RYD) in protecting membrane fluidity of mitochondrion in brain and liver of D-galactose induced subacute senile mice.


METHODS
Forty ICR mice were randomly divided into the youth control group, the model group, the high, middle and low-dose RYD groups. The membrane fluidity of mitochondrion in liver and brain cell was measured, and the malondialdehyde (MDA) content of mitochondrion was determined and analyzed.


RESULTS
In the model group, the membrane fluidity of mitochondrion in hepatic and cerebral cells significantly decreased, and the MDA concentration of mitochondrion increased. RYD could significantly reduce the MDA concentration of mitochondrion, markedly increase the membrane fluidity of mitochondrion in a dose-dependent manner.


CONCLUSIONS
RYD plays a role in anti-aging through protecting the membrane fluidity of mitochondrion in hepatic and cerebral cells and decreasing the MDA concentration of mitochondrion changing with ageing.
Deng
Hong
H
Department of Traditional Chinese Medicine, General Hospital of Tianjin Medical University, Tianjin. hdeng5588@163.com
Tang
Fang
F
D000375:Aging / Q000187:drug effects* / Q000502:physiology; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism / Q000502:physiology; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D008315:Malondialdehyde / Q000378:metabolism; D008516:Medicine, Chinese Traditional; D008560:Membrane Fluidity / Q000187:drug effects*; D051379:Mice; D008813:Mice, Inbred ICR; D008928:Mitochondria / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism / Q000502:physiology; D005894:Panax; D020011:Protective Agents / Q000494:pharmacology*
D004365:Drugs, Chinese Herbal; D020011:Protective Agents; D008315:Malondialdehyde