Influence of comorbid depression on fear in posttraumatic stress disorder: an fMRI study.
Posttraumatic Stress Disorder (PTSD) is thought to involve a dysregulation of medial prefrontal-amygdala activity in response to fear. PTSD studies, however, have been confounded by comorbid depression, which shows similar dysregulation. Amygdala and medial prefrontal activity was reduced in PTSD-depression compared to PTSD-alone samples, highlighting the need to account for comorbidity.
Kemp
Andrew H
AH
Brain Dynamics Centre, Westmead Hospital and Western Clinical, School University of Sydney, Sydney, NSW, Australia. kempa@psych.usyd.edu.au
Felmingham
Kim
K
Das
Pritha
P
Hughes
Gerard
G
Peduto
Anthony S
AS
Bryant
Richard A
RA
Williams
Leanne M
LM
D000328:Adult; D000679:Amygdala / Q000503:physiopathology; D015897:Comorbidity; D003865:Major Depressive Disorder / Q000453:epidemiology* / Q000503:physiopathology; D005149:Facial Expression; D005239:Fear; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009415:Nerve Net / Q000503:physiopathology; D017397:Prefrontal Cortex / Q000503:physiopathology; D012720:Severity of Illness Index; D013313:Stress Disorders, Post-Traumatic / Q000453:epidemiology* / Q000503:physiopathology; D011795:Surveys and Questionnaires