title: Contact allergy to acrylates/methacrylates in the acrylate and nail acrylics series in southern Sweden: simultaneous positive patch test reaction patterns and possible screening allergens.
abstract: In a recent study we showed that all our dental personnel/patients were detected with 2-hydroxyethyl methacrylate (2-HEMA) and 2,2-bis[4-(2-hydroxy-3-methacryloxypropoxy)phenyl]propane (bis-GMA). We studied 90 patients tested to the acrylate and nail acrylics series at our department over a 10 year period to see whether screening allergens could be found. Patch testing with an acrylate and nail acrylics series was performed. Among the 10 acrylate/methacrylate-allergic occupational dermatitis patients tested to the acrylate series, the most common allergens were triethyleneglycol diacrylate (TREGDA, 8), diethyleneglycol diacrylate (5), and 1,4-butanediol diacrylate (BUDA, 5). All 10 of these patients would have been picked up by a short screening series combining TREGDA, 2-hydroxypropyl methacrylate (2-HPMA), and BUDA or 1,6-hexanediol diacrylate (HDDA). Among the 14 acrylate/methacrylate-allergic nail patients, the most common allergens were ethylene glycol dimethacrylate (EGDMA, 11), 2-HEMA, (9), and triethyleneglycol dimethacrylate (9). Screening for 3 allergens i.e. 2-HEMA plus EGDMA plus TREGDA, would have detected all 14 nail patients. A short screening series combining 2-HEMA, EGDMA, TREGDA, 2-HPMA, bis-GMA, and BUDA or HDDA would have picked up all our past study patients (dental, industrial, and nail) with suspected allergy to acrylate/methacrylate allergens.
authors.affiliation: National Skin Centre, Singapore. anthonygoon@nsc.gov.sg
authors.forename: Anthony
authors.initials: A
authors.lastname: Teik-Jin Goon
authors.forename: Magnus
authors.initials: M
authors.lastname: Bruze
authors.forename: Erik
authors.initials: E
authors.lastname: Zimerson
authors.forename: Chee-Leok
authors.initials: CL
authors.lastname: Goh
authors.forename: Marléne
authors.initials: M
authors.lastname: Isaksson
mesh_terms: D000179:Acrylates / Q000009:adverse effects* / Q000737:chemistry; D000328:Adult; D000485:Allergens / Q000009:adverse effects*; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis / Q000209:etiology*; D009783:Dermatitis, Occupational / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015394:Molecular Structure; D016273:Occupational Exposure / Q000009:adverse effects*; D010328:Patch Tests; D012189:Retrospective Studies; D012867:Skin / Q000473:pathology; D013548:Sweden
chemical_list: D000179:Acrylates; D000485:Allergens