title: Motor recovery after Guillain-Barré syndrome in childhood.
abstract: OBJECTIVE
  To determine the clinical factors that modify the recovery time for gait after Guillain-Barré syndrome (GBS) in childhood.
  
  
  METHODS
  Medical records of patients admitted to Instituto de Ortopedia Infantil Roosevelt (IOIR) between years 1991 and 2001, were reviewed. Age, sex, cranial nerve impairment, requirement of assisted ventilation, number of days of assisted ventilation, muscular strength at day 10 of the disease, presence of quadriplegia, intravenous infusion of human gamma globulins (IVIG), were taken as independent variables. The number of needed days to reach Hughes State III was taken as the major outcome. First, univariate analysis was performed and with the factors that showed a statistically significant association with recovery time, multiple linear regression analysis and Cox regression were also performed.
  
  
  RESULTS
  Data of 332 children under 15 years old was collected. (Mean age: 7.1 years). A sample of 215 children was gathered for the study, all of them were regarded as functional states IV or V. Acute Motor Axonal Neuropathy (AMAN) was found in 30% of all cases. In the univariate analysis Cranial nerve impairment, requirement of assisted ventilation, presence of quadriplegia and presence of non-excitable motor nerves were associated with delayed motor recovery time. Patients who received IVIG reached Hughes state III faster than those who received only support treatment. This finding, that was more important in the presence of Acute Inflammatory Demyelinating Polyradiculoneuropathy (AIDP), lost its value in the Cox regression analysis. In the multivariate analysis, muscular strength, assessed at day 10 of the disease was the most important predictor to determine motor recovery. The presence of quadriplegia was strongly associated with a delayed recovery time. Relative risk: 3.3 (95% Confidence Interval 2.1 - 5.2).
  
  
  CONCLUSIONS
  Muscular strength at day 10 of the disease is the most useful clinical factor to determine prognosis of motor recovery in children who have suffered Guillain-Barré syndrome.
authors.affiliation: Department of Physical Medicine and Rehabilitation, Universidad Nacional de Colombia and Instituto de Ortopedia Infantil Roosevelt, Colombia. foritzc@unal.edu.co
authors.forename: Fernando
authors.initials: F
authors.lastname: Ortiz-Corredor
authors.forename: Marta
authors.initials: M
authors.lastname: Peña-Preciado
authors.forename: Jorge
authors.initials: J
authors.lastname: Díaz-Ruíz
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D003105:Colombia; D005260:Female; D020275:Guillain-Barre Syndrome / Q000534:rehabilitation*; D006801:Humans; D007223:Infant; D008297:Male; D009048:Motor Skills; D015999:Multivariate Analysis; D020127:Recovery of Function; D012044:Regression Analysis