title: In vivo degradation of poly(DTE carbonate) membranes. Analysis of the tissue reactions and mechanical properties.
abstract: Different bioabsorbable polymers and their co-polymers have been used to construct an optimal material for guided bone regeneration applications. Our aim was to evaluate a novel bioabsorbable material in a soft tissue environment. In this study, a poly(DTE carbonate) membrane (0.2-0.3 mm) was implanted into 20 NZW rabbits' subcutaneous pouches for 6, 12, 24 and 52 weeks. The material was evaluated by means of histological reactions to the material and mechanical properties of the membrane. Based on this study, it can be concluded that poly(DTE carbonate) elicited a very modest foreign body reaction in the soft tissues. This reaction was uniform throughout the study. Varying amounts of calcification was seen in the fibrous capsule surrounding the implant. The number of calcified bodies did not correlate to healing time.
authors.affiliation: Department of Oral and Maxillofacial Surgery, University of Helsinki, Helsinki, Finland. antti.asikainen@implantcenter.fi
authors.forename: Antti J
authors.initials: AJ
authors.lastname: Asikainen
authors.forename: Mika
authors.initials: M
authors.lastname: Pelto
authors.forename: Jukka
authors.initials: J
authors.lastname: Noponen
authors.forename: Minna
authors.initials: M
authors.lastname: Kellomäki
authors.forename: Harri
authors.initials: H
authors.lastname: Pihlajamäki
authors.forename: Christian
authors.initials: C
authors.lastname: Lindqvist
authors.forename: Riitta
authors.initials: R
authors.lastname: Suuronen
mesh_terms: D020341:Absorbable Implants; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D001673:Biodegradation, Environmental; D005260:Female; D005549:Foreign-Body Reaction; D008422:Materials Testing; D008970:Molecular Weight; D009757:Nylons / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry; D011208:Powders; D011817:Rabbits; D013314:Stress, Mechanical; D013696:Temperature; D013997:Time Factors
chemical_list: D001672:Biocompatible Materials; D009757:Nylons; D011108:Polymers; D011208:Powders; C114440:poly(DTE carbonate)