title: Optimization of encoding specificity for the diagnosis of early AD: the RI-48 task.
abstract: The aim of this study was to evaluate the discriminant validity of the RI-48 test, a shorter French version of the Category Cued Recall portion of the Double Memory Test developed initially by Buschke and colleagues (1997), in the diagnosis of mild and very mild Alzheimer disease (AD). The distinctive feature of the RI-48 task is that encoding specificity was increased by adding an immediate cued recall stage at the encoding phase. The results show that the RI-48 task seems to be well adapted to the clinical context and to have good psychometric properties, in particular a lack of a ceiling effect. Moreover, this task appears to be especially well suited for the diagnosis of both mild and very mild AD (sensitivity of 93% and 83.8%). From a more theoretical point of view, this study confirms the importance of optimizing the encoding specificity for the diagnosis of very mild AD, since the more encoding specificity is accentuated, the more discriminating power is increased for the diagnosis of very mild AD.
authors.affiliation: Neuropsychology Unit, University of Liège, Belgium. stephane.adam@ulg.ac.be
authors.forename: S
authors.initials: S
authors.lastname: Adam
authors.forename: M
authors.initials: M
authors.lastname: Van der Linden
authors.forename: A
authors.initials: A
authors.lastname: Ivanoiu
authors.forename: A-C
authors.initials: AC
authors.lastname: Juillerat
authors.forename: S
authors.initials: S
authors.lastname: Bechet
authors.forename: E
authors.initials: E
authors.lastname: Salmon
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000175:diagnosis* / Q000503:physiopathology*; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D011939:Mental Recall / Q000502:physiology*; D008875:Middle Aged; D009483:Neuropsychological Tests; D011237:Predictive Value of Tests; D011594:Psychometrics; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012680:Sensitivity and Specificity