title: Impact of the Haemophilus influenzae type b vaccination program on HIB meningitis in Brazil.
abstract: This study aimed to evaluate the impact of vaccination against Haemophilus influenzae type b (HIB) in Brazil on the morbidity, mortality, and case fatality of HIB meningitis, using the Ministry of Health database and population data from the Brazilian Institute of Geography and Statistics (Instituto Brasileiro de Geografia e Estatística--IBGE). Impact was evaluated through a time series analysis (1983-2002), using regression forecasting (RF) by dividing the time series into two periods: (a) historical (1983-1998) and (b) validation (1999-2002). Impact of the vaccination was positive, although more significant for incidence and mortality than for case fatality rates.
authors.affiliation: Departamento de Medicina Social, Universidade Federal do Triângulo Mineiro, Uberaba, Brasil.
authors.forename: Sybelle de Souza Castro
authors.initials: Sde S
authors.lastname: Miranzi
authors.forename: Suzana Alves
authors.initials: SA
authors.lastname: de Moraes
authors.forename: Isabel Cristina Martins
authors.initials: IC
authors.lastname: de Freitas
mesh_terms: D001938:Brazil / Q000453:epidemiology; D002675:Child, Preschool; D002984:Clinical Laboratory Information Systems; D005544:Forecasting; D018073:Haemophilus Vaccines / Q000008:administration & dosage*; D019741:Haemophilus influenzae type b / Q000276:immunology*; D006801:Humans; D017589:Immunization Programs; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008583:Meningitis, Haemophilus / Q000453:epidemiology* / Q000401:mortality / Q000517:prevention & control*; D012044:Regression Analysis; D016019:Survival Analysis; D014611:Vaccination / Q000592:standards*; D018074:Vaccines, Conjugate
chemical_list: D018073:Haemophilus Vaccines; D018074:Vaccines, Conjugate