title: Renoprotective effects of rosiglitazone in stroke-prone spontaneously hypertensive rats.
abstract: OBJECTIVE
  Rosiglitazone (RGTZ) has a protective effect against various types of injury. We evaluated the effects of RGTZ on renal injury in a stroke-prone spontaneously hypertensive rat (SHRSP) model.
  
  
  METHODS
  Male SHRSP rats were observed with or without RGTZ treatment for 10 weeks. Age-matched male Wistar-Kyoto rats were used as controls. The effect of RGTZ on hypertensive nephropathy was evaluated by assessing renal function, pathology, pro-inflammatory cytokine (osteopontin), profibrotic cytokine (betaig-h3), apoptotic cell death (TUNEL staining and caspase 3 expression), marker of oxidative stress (8-OHdG) and endothelial damage (eNOS).
  
  
  RESULTS
  RGTZ treatment improved renal function and histopathology compared with SHRSP rats without treatment (p < 0.05). Osteopontin and betaig-h3 were significantly increased in SHRSP rat kidneys, but RGTZ treatment decreased both mediators. Apoptotic cell death was increased in renal tubular cells in the injured area in SHRSP rat kidneys, but RGTZ treatment decreased apoptotic cell death and caspase 3 expression. Increased urinary 8-OHdG excretion and decreased eNOS in SHRSP rats was reversed with RGTZ treatment.
  
  
  CONCLUSIONS
  RGTZ protects hypertensive nephropathy in SHRSP rats.
authors.affiliation: Cell Death Research Center, Division of Nephrology, Kangnam St. Mary's Hospital, Catholic University of Korea, Seoul, Korea.
authors.forename: Bum Soon
authors.initials: BS
authors.lastname: Choi
authors.forename: Hyun Ju
authors.initials: HJ
authors.lastname: Yang
authors.forename: Kyung Ohk
authors.initials: KO
authors.lastname: Ahn
authors.forename: Sun Woo
authors.initials: SW
authors.lastname: Lim
authors.forename: Su Hyun
authors.initials: SH
authors.lastname: Kim
authors.forename: Jin Young
authors.initials: JY
authors.lastname: Kim
authors.forename: Can
authors.initials: C
authors.lastname: Li
authors.forename: Yong Soo
authors.initials: YS
authors.lastname: Kim
authors.forename: Jin
authors.initials: J
authors.lastname: Kim
authors.forename: Byung Kee
authors.initials: BK
authors.lastname: Bang
authors.forename: Chul Woo
authors.initials: CW
authors.lastname: Yang
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D006973:Hypertension / Q000473:pathology / Q000517:prevention & control* / Q000652:urine; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D000077154:Rosiglitazone; D020521:Stroke / Q000473:pathology / Q000517:prevention & control* / Q000652:urine; D045162:Thiazolidinediones / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D045162:Thiazolidinediones; D000077154:Rosiglitazone