Effects of zonisamide on experimental tremors in rats.
OBJECTIVE
To study the effect of zonisamide on experimental tremors in rats.


METHODS
Effect of zonisamide on harmaline- or oxotreorine-induced tremors, and tacrine-induced tremulous jaw movements (TJMs) was studied.


RESULTS
Zonisamide significantly suppressed both harmaline- and oxotremorine-induced tremors dose-dependently. Zonisamide also significantly suppressed tacrine-induced TJMs, and this effect was not lost under conditions of monoamine-depletion or dopaminergic blockade.


CONCLUSIONS
The anti-tremor effects of zonisamide may be achieved by a non-dopaminergic mechanism. Since it effectively suppressed tremors that are based on different kinds of tremors, we propose a novel perspective of clinical potential of zonisamide as a non-specific, anti-tremor drug.
Miwa
Hideto
H
Department of Neurology, Wakayama Medical University, 811-1 Kimiidera, Wakayama City, Wakayama 641-8510, Japan. h-miwa@wakayama-med.ac.jp
Hama
Kiwa
K
Kajimoto
Yoshinori
Y
Kondo
Tomoyoshi
T
D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use*; D000697:Central Nervous System Stimulants / Q000633:toxicity; D002800:Cholinesterase Inhibitors; D006246:Harmaline / Q000633:toxicity; D007555:Isoxazoles / Q000627:therapeutic use*; D008297:Male; D018721:Muscarinic Agonists / Q000633:toxicity; D010095:Oxotremorine / Q000633:toxicity; D051381:Rats; D017207:Rats, Sprague-Dawley; D013619:Tacrine / Q000633:toxicity; D014202:Tremor / Q000139:chemically induced / Q000188:drug therapy*; D000078305:Zonisamide
D000927:Anticonvulsants; D000697:Central Nervous System Stimulants; D002800:Cholinesterase Inhibitors; D007555:Isoxazoles; D018721:Muscarinic Agonists; D000078305:Zonisamide; D013619:Tacrine; D010095:Oxotremorine; D006246:Harmaline