title: Histological comparison of demineralized bone matrix and the Ricinus communis polymer on bone regeneration.
abstract: OBJECTIVE
  The aim of the present study is to make a histologic analysis the effects of a human demineralized bone matrix and a polyurethane resin derived from the Ricinus communis, on bone regeneration process.
  
  
  METHODS
  For this, 24 rabbits were submitted to two surgical calvaria bone defects, one on the right and another on the left side of the parietal suture. The animals were divided in two groups. In group I the experimental defect (right side) was treated with a human demineralized bone matrix, while in group II the experimental cavity was treated with the polyurethane resin derived from Ricinus communis. The control defects were filled with the animals own blood. The animals were slaughtered after subsequent periods of 04, 07 and 15 weeks.
  
  
  RESULTS
  The histological analysis revealed that all groups (control and experiment), presented increased bone regeneration with time, but this repair was faster in the control group, even showing important decrease in defect thickness.
  
  
  CONCLUSIONS
  Both materials proved to be biologically compatible, however polyurethane was more slowly resorbed presented considerable better results when compared with demineralized bone matrix.
authors.affiliation: Faculdade de Odontologia de Pernambuco, Universidade de Pernambuco.
authors.forename: José Rodrigues
authors.initials: JR
authors.lastname: Laureano Filho
authors.forename: Bruno de Lira
authors.initials: Bde L
authors.lastname: Castelo Branco
authors.forename: Emanuel Sávio Souza
authors.initials: ES
authors.lastname: Andrade
authors.forename: José Ricardo de Albergaria
authors.initials: JR
authors.lastname: Barbosa
mesh_terms: D000818:Animals; D001704:Biopolymers / Q000627:therapeutic use*; D001857:Bone Matrix / Q000637:transplantation*; D001861:Bone Regeneration / Q000502:physiology*; D018786:Bone Substitutes / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D023421:Models, Animal; D011817:Rabbits; D012278:Ricinus; D012886:Skull / Q000473:pathology / Q000601:surgery*
chemical_list: D001704:Biopolymers; D018786:Bone Substitutes