title: Gastric ulcer after laparoscopic fundoplication for gastroesophageal reflux disease: significance of the eradication of Helicobacter pylori.
abstract: The occurrence of gastric ulcers after laparoscopic fundoplication for gastroesophageal reflux disease is not uncommon. Between December 1994 and December 2004, we performed laparoscopic fundoplication in 180 patients, of whom 4 (2.2%) men developed a gastric ulcer during follow-up. The ulcers occurred predominantly in the upper part of the lesser curvature of the stomach, which is definitely different from the usual location of gastric peptic ulcers. All cases we experienced had Helicobacter pylori infection and eradication was attempted in all of them. Although eradication was not possible in 1 patient because of adverse effects to the drugs, successful eradication was obtained in the remaining 3 patients. After successful eradication, these 3 patients were placed under observation without medication and the ulcer has not recurred. The eradication of H. pylori may be an effective therapeutic means to prevent gastric ulcers recurrence after fundoplication.
authors.affiliation: Department of Surgery, Jikei University School of Medicine, Minato-ku, Tokyo, Japan. surgomura@jikei.ac.jp
authors.forename: Nobuo
authors.initials: N
authors.lastname: Omura
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Kashiwagi
authors.forename: Fumiaki
authors.initials: F
authors.lastname: Yano
authors.forename: Kazuto
authors.initials: K
authors.lastname: Tsuboi
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Ishibashi
authors.forename: Naruo
authors.initials: N
authors.lastname: Kawasaki
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Akira
authors.initials: A
authors.lastname: Matsumoto
authors.forename: Norio
authors.initials: N
authors.lastname: Mitsumori
authors.forename: Mitsuyoshi
authors.initials: M
authors.lastname: Urashima
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Yanaga
mesh_terms: D000368:Aged; D018662:Fundoplication / Q000379:methods*; D005764:Gastroesophageal Reflux / Q000601:surgery*; D016481:Helicobacter Infections / Q000601:surgery; D016480:Helicobacter pylori / Q000302:isolation & purification*; D006801:Humans; D010535:Laparoscopy; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D013276:Stomach Ulcer / Q000209:etiology* / Q000382:microbiology*