title: Crystal structure of ABT-737 complexed with Bcl-xL: implications for selectivity of antagonists of the Bcl-2 family.
authors.forename: E F
authors.initials: EF
authors.lastname: Lee
authors.forename: P E
authors.initials: PE
authors.lastname: Czabotar
authors.forename: B J
authors.initials: BJ
authors.lastname: Smith
authors.forename: K
authors.initials: K
authors.lastname: Deshayes
authors.forename: K
authors.initials: K
authors.lastname: Zobel
authors.forename: P M
authors.initials: PM
authors.lastname: Colman
authors.forename: W D
authors.initials: WD
authors.lastname: Fairlie
mesh_terms: D019943:Amino Acid Substitution; D000818:Animals; D017209:Apoptosis; D051017:Apoptosis Regulatory Proteins / Q000737:chemistry / Q000378:metabolism; D000072224:Bcl-2-Like Protein 11; D001713:Biphenyl Compounds / Q000737:chemistry* / Q000378:metabolism*; D006801:Humans; D008565:Membrane Proteins / Q000737:chemistry / Q000378:metabolism; D051379:Mice; D009596:Nitrophenols / Q000737:chemistry* / Q000378:metabolism*; D010879:Piperazines / Q000737:chemistry / Q000378:metabolism; D017434:Protein Structure, Tertiary; D011518:Proto-Oncogene Proteins / Q000737:chemistry / Q000378:metabolism; D013449:Sulfonamides / Q000737:chemistry* / Q000378:metabolism*; D051020:bcl-X Protein / Q000737:chemistry* / Q000378:metabolism*
chemical_list: C501332:ABT-737; D051017:Apoptosis Regulatory Proteins; C494811:BCL2L1 protein, human; C000606775:BCL2L11 protein, human; D000072224:Bcl-2-Like Protein 11; C000606776:Bcl2l11 protein, mouse; D001713:Biphenyl Compounds; D008565:Membrane Proteins; D009596:Nitrophenols; D010879:Piperazines; D011518:Proto-Oncogene Proteins; D013449:Sulfonamides; D051020:bcl-X Protein