title: Cystic adenomatoid malformation in children: CT histopathological correlation.
abstract: OBJECTIVE
  This study was performed to assess the accuracy of computed tomography (CT) in classifying the various types of cystic adenomatoid malformation (CAM) of the lung, as described by Stocker et al., taking histopathology as the gold standard.
  
  
  METHODS
  We retrospectively reviewed six cases of histologically proven CAM. Chest radiography, chest CT and histopathology results were available for all patients. The CT images were reviewed blinded to the histological findings, and attention was paid to the number and size of cysts so as to classify the lesions into the three groups described by Stocker et al. The classification of lesions based on the CT images was then correlated to the histopathological findings.
  
  
  RESULTS
  Areas with small-sized cysts (<2 cm) were detected by CT in two patients (33.3%), areas with large cysts (>2 cm) were seen in three cases (50%) whereas in the remaining case, the diagnosis was mixed type I and type II CAM. In one patient with type I CAM, an area of low-density consolidation around the cysts was interpreted as CAM in a context of pulmonary sequestration. The CT classification based on Stocker et al.'s categories was in agreement with the histopathological findings in four cases, whereas in the remaining two cases, the lesions were classed as type I or II on CT and as mixed (type I and II) lesions at histopathology. In one case, the CT classification was correct, but the histopathology revealed the coexistence of pulmonary sequestration.
  
  
  CONCLUSIONS
  In our study, there was concordance between CT and histopathology in 66.7% of cases, whereas in 33.3% histopathology revealed areas with mixed grade lesions. CT proved to be accurate in identifying and characterising CAM and provided important information on lesion site and extension.
authors.affiliation: Servizio di radiologia-Presidio Salesi, Azienda Ospedaliero-Universitaria Ospedali Riuniti-Ancona, Via Corridoni 11, I-60123 Ancona, Italy. lanzacecilia@hotmail.com
authors.forename: C
authors.initials: C
authors.lastname: Lanza
authors.forename: V
authors.initials: V
authors.lastname: Bolli
authors.forename: V
authors.initials: V
authors.lastname: Galeazzi
authors.forename: B
authors.initials: B
authors.lastname: Fabrizzi
authors.forename: G
authors.initials: G
authors.lastname: Fabrizzi
mesh_terms: D002648:Child; D002675:Child, Preschool; D015615:Cystic Adenomatoid Malformation of Lung, Congenital / Q000000981:diagnostic imaging* / Q000473:pathology*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D015203:Reproducibility of Results; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed