Tumorigenesis in the brain: location, location, location.
Emerging evidence from numerous laboratories supports the notion that brain tumors arise from cells with stem cell/neuroglial progenitor cell properties ("cancer stem cells"). Two recent studies suggest that histologically similar tumors from different brain regions are molecularly distinct because they arise from distinct populations of site-restricted progenitor cells. These new findings imply an interaction between the cell of origin, the tumor microenvironment, and specific cancer-causing genetic changes in the evolution of central nervous system tumors.
Gilbertson
Richard J
RJ
Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA. Richard.Gilberston@stjude.org
Gutmann
David H
DH
D000818:Animals; D001932:Brain Neoplasms / Q000473:pathology* / Q000503:physiopathology*; D002471:Cell Transformation, Neoplastic; D006801:Humans; D008959:Models, Neurological; D014411:Neoplastic Stem Cells / Q000473:pathology*