title: Antinociceptive effect of amitriptyline in mice of acute pain models.
abstract: Tricyclic antidepressant drugs induce antinociceptive effect and suggest that their analgesic action could be related to the monoaminergic activity of the drugs. The analgesic activity of amitriptyline was observed in mouse models of acute pain. Mice were divided into different groups and were given amitriptyline in different doses alone and in combination with morphine. Reaction time in Hot-Plate and Tail-Flick tests was observed. Results showed that amitriptyline had antinociceptive effect in acute pain state in experimental models. Amitriptyline in combination with morphine had better analgesic effect than the morphine alone in Hot-Plate test.
authors.affiliation: Department of Pharmacology, B. P. Koirala Institute of Health Sciences, Dharan, Nepal. keshabpaudel@gmail.com
authors.forename: Keshab Raj
authors.initials: KR
authors.lastname: Paudel
authors.forename: Balbhadra Prasad
authors.initials: BP
authors.lastname: Das
authors.forename: G P
authors.initials: GP
authors.lastname: Rauniar
authors.forename: Himal
authors.initials: H
authors.lastname: Sangraula
authors.forename: Satish
authors.initials: S
authors.lastname: Deo
authors.forename: S K
authors.initials: SK
authors.lastname: Bhattacharya
mesh_terms: D000208:Acute Disease; D000639:Amitriptyline / Q000494:pharmacology* / Q000627:therapeutic use*; D018712:Analgesics, Non-Narcotic / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D051379:Mice; D010146:Pain / Q000188:drug therapy* / Q000473:pathology
chemical_list: D018712:Analgesics, Non-Narcotic; D000639:Amitriptyline