The Candida albicans gene HGT12 (orf19.7094) encodes a hexose transporter.
Yeast cells of the human pathogen Candida albicans that enter the bloodstream can be engulfed by macrophage cells but survive in, and can escape from, the phagolysosome. The C. albicans gene HGT12, which is specifically expressed during macrophage infection, encodes a protein that transports fructose, glucose and mannose. Expression of this hexose transporter along with the shift from glycolysis to gluconeogenesis that occurs in these phagocytosed cells suggests a requirement for glucose that can be supplied in part by uptake from the lumen of the phagolysosome.
Luo
Lin
L
Institute of Molecular Biosciences, Massey University, New Zealand.
Tong
XingZhang
X
Farley
Peter C
PC
D002176:Candida albicans / Q000235:genetics*; D005800:Genes, Fungal; D005947:Glucose / Q000378:metabolism; D008264:Macrophages / Q000378:metabolism; D009004:Monosaccharide Transport Proteins / Q000235:genetics* / Q000502:physiology*; D010588:Phagosomes / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000378:metabolism
D009004:Monosaccharide Transport Proteins; D005947:Glucose