title: 5-HT2A SNPs and the Temperament and Character Inventory.
abstract: Temperamental traits, the most basic part of personality, have been largely correlated with neurotransmitter systems and are under genetic control. Among serotonin candidates, the 2A receptor (5-HT(2A)) received considerable attention. We analyzed four SNPs (rs643627, rs594242, rs6311 and rs6313) in the 5-HT(2A) gene and their association with personality traits, as measured with the Temperament and Character Inventory (TCI). The sample was composed of three sub-groups: two German sub-samples, consisting of a healthy group of 289 subjects (42.6% males, mean age: 45.2+/-14.9) and a psychiatric patient group of 111 suicide attempters (38.7% males, mean age: 39.2+/-13.6), and an Italian sub-sample, composed of 60 mood disorder patients (35.0% males, mean age: 44.0+/-14.8). Controlling for sex, age and educational level, the SNPs were not strongly associated with personality dimensions. Only the rs594242 showed an association with Self-Directedness (p=0.003) in the German sample, while rs6313 was marginally associated with Novelty Seeking (p=0.01) in the Italian sample. We conclude that 5-HT(2A) SNPs may marginally modulate personality traits but further studies are required.
authors.affiliation: Institute of Psychiatry University of Bologna, Viale Carlo Pepoli 5, 40123 Bologna, Italy. alessandro.serretti@unibo.it
authors.forename: Alessandro
authors.initials: A
authors.lastname: Serretti
authors.forename: Raffaella
authors.initials: R
authors.lastname: Calati
authors.forename: Ina
authors.initials: I
authors.lastname: Giegling
authors.forename: Annette M
authors.initials: AM
authors.lastname: Hartmann
authors.forename: Hans-Jürgen
authors.initials: HJ
authors.lastname: Möller
authors.forename: Cristina
authors.initials: C
authors.lastname: Colombo
authors.forename: Dan
authors.initials: D
authors.lastname: Rujescu
mesh_terms: D000328:Adult; D003431:Cross-Cultural Comparison; D004252:DNA Mutational Analysis; D005260:Female; D005858:Germany / Q000453:epidemiology; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D001523:Mental Disorders / Q000453:epidemiology / Q000235:genetics; D008875:Middle Aged; D015999:Multivariate Analysis; D010551:Personality / Q000235:genetics*; D010554:Personality Disorders / Q000235:genetics; D010555:Personality Inventory / Q000706:statistics & numerical data*; D020641:Polymorphism, Single Nucleotide; D011897:Random Allocation; D044402:Receptor, Serotonin, 5-HT2A / Q000235:genetics*; D013694:Temperament
chemical_list: D044402:Receptor, Serotonin, 5-HT2A