Effects of a hop water extract on the compound 48/80-stimulated vascular permeability in ICR mice and histamine release from OVA-sensitized BALB/c mice.
The antiallergic properties of a hop water extract (HWE) were studied by evaluating the Evans blue leakage from ICR mice caused by compound 48/80 stimulation, and the histamine release from ovalbumin (OVA)-sensitized BALB/c mice. An oral administration of HWE significantly inhibited the vascular permeability and histamine release. HWE itself did not have any influence on the total and antigen-specific immunoglobulin E (IgE) production in OVA-sensitized mice. These results indicate that HWE exerted an antiallergic effect by inhibiting the release of chemical mediators from mast cells and basophiles.
Segawa
Shuichi
S
Frontier Laboratories of Value Creation, Sapporo Breweries, Japan. syuuichi.segawa@sapporobeer.co.jp
Takata
Yoshihiro
Y
Kaneda
Hirotaka
H
Watari
Junji
J
D000818:Animals; D018926:Anti-Allergic Agents / Q000494:pharmacology*; D001491:Basophils / Q000187:drug effects / Q000276:immunology; D002199:Capillary Permeability / Q000187:drug effects* / Q000276:immunology; D027582:Humulus / Q000276:immunology*; D008407:Mast Cells / Q000187:drug effects / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D008813:Mice, Inbred ICR; D010047:Ovalbumin / Q000276:immunology; D010936:Plant Extracts / Q000494:pharmacology*; D014867:Water; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology
D018926:Anti-Allergic Agents; D010936:Plant Extracts; D014867:Water; D003189:p-Methoxy-N-methylphenethylamine; D010047:Ovalbumin