title: Effects of antituberculosis treatment on self assessment, perceptual analysis and acoustic analysis of voice quality in laryngeal tuberculosis patients.
abstract: OBJECTIVE
  To evaluate the effects of antituberculosis treatment on the voice quality of laryngeal tuberculosis patients, measured by patient self-assessment, perceptual analysis and acoustic analysis.
  
  
  METHODS
  A total of 14 laryngeal tuberculosis patients were enrolled. Laryngeal tuberculosis was established either by biopsy and histopathological examination or by rapid regression of the laryngeal lesions after antituberculosis medication. Before and after treatment, all patients were evaluated perceptually (on a scale of zero to three), and 12 assessed their own voices using the voice handicap index-10 scale. Acoustic analysis was performed to allow objective evaluation.
  
  
  RESULTS
  Patients' ages ranged from 21 to 72 years (mean, 41). The male to female ratio was 12:2. Eight patients (57 per cent) had tuberculous involvement of the epiglottis, four (28 per cent) had involvement of the aryepiglottic fold and eight (57 per cent) had involvement of the false vocal folds. The glottis was the less commonly involved part of the larynx, including true vocal folds (28 per cent, n = 4) and posterior commissure (14 per cent, n = 2). Perceptual evaluation, on a scale of zero to three, gave the patients a median score of six; after commencement of treatment, the median score decreased to two. The mean voice handicap index-10 score decreased from 24 to 12 after treatment. An obvious improvement in acoustic analytical parameters was also found following treatment.
  
  
  CONCLUSIONS
  Antituberculosis treatment clearly improved the voice outcomes of laryngeal tuberculosis patients, according to self-assessment, perceptual analysis and acoustic analysis.
authors.affiliation: Department of Otolaryngology, Medical Faculty, Gaziomanpasa University, Tokat, Turkey. kursatyelken@yahoo.com
authors.forename: K
authors.initials: K
authors.lastname: Yelken
authors.forename: M
authors.initials: M
authors.lastname: Guven
authors.forename: M
authors.initials: M
authors.lastname: Topak
authors.forename: E
authors.initials: E
authors.lastname: Gultekin
authors.forename: F
authors.initials: F
authors.lastname: Turan
mesh_terms: D000328:Adult; D000368:Aged; D000995:Antitubercular Agents / Q000627:therapeutic use*; D004724:Endoscopy; D005260:Female; D006801:Humans; D007828:Laryngoscopy; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012647:Self-Assessment; D012720:Severity of Illness Index; D013018:Sound Spectrography / Q000379:methods; D013067:Speech Perception; D016896:Treatment Outcome; D014387:Tuberculosis, Laryngeal / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology; D014832:Voice Disorders / Q000175:diagnosis / Q000382:microbiology*; D014833:Voice Quality / Q000187:drug effects*
chemical_list: D000995:Antitubercular Agents