title: [Study on preparation technology of plumula nelumbinis Alkaloid Dripping Pill and determination of content by HPLC].
abstract: OBJECTIVE
  To determine the optimum technical parameters through controlling the different factors and the content of Dripping Pill.
  
  
  METHODS
  Time of dissolution, spherical degree and pill weight as parameters, the influential factors were investigated by orthogonal test and then to determine the content of liensinine, isoliensinine, neferine in plumula nelumbinis Alkaloid Dripping Pill.
  
  
  RESULTS
  The optimum condition: 75% PEG4000 as matrix, methyl-silicon oil as refrigerant, 4 cm dripping distance, 10 degrees C refrigerant, 30 drippings per minute.
  
  
  CONCLUSIONS
  The good quality pills can be produced through this process and the HPLC determination method is simple, reliable and can be used in the quality control of plumula nelumbinis Alkaloid Dripping Pill.
authors.affiliation: Institute of Chinese Meteria Medica, China Academg of Chinese Medical Sciences, Beijing 100700, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.forename: Hong-Jie
authors.initials: HJ
authors.lastname: Wang
authors.forename: Nan
authors.initials: N
authors.lastname: Si
authors.forename: Bao-Lin
authors.initials: BL
authors.lastname: Bian
mesh_terms: D000470:Alkaloids / Q000032:analysis* / Q000737:chemistry; D044182:Benzylisoquinolines / Q000032:analysis / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D007546:Isoquinolines / Q000032:analysis / Q000737:chemistry; D008863:Microspheres; D031653:Nelumbo / Q000737:chemistry*; D010316:Particle Size; D010636:Phenols / Q000032:analysis / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry*; D011786:Quality Control; D012639:Seeds / Q000737:chemistry; D012995:Solubility; D013678:Technology, Pharmaceutical / Q000379:methods*
chemical_list: D000470:Alkaloids; D044182:Benzylisoquinolines; D007546:Isoquinolines; D010636:Phenols; C499779:isoliensinine; C057222:neferine; C080095:liensinine; D011092:Polyethylene Glycols