[Fluorescence detection of chlorine E6 based photosensitizer in urinary bladder tumors].
The authors present pilot experience with accumulation and distribution of chlorine E6 based photosensitizer in unaffected mucosa and tumor of human urinary bladder (UB). Local fluorescence spectroscopy in vivo has shown that 2-3 hours after intravenous injection of the photosensitizer in a dose 1 mg/kg its exogenic fluorescence is detected in the tumor but not in unaffected UB mucosa. This indicates selective accumulation of the sensitizer in UB tumors. Thus, chlorine E6 based photosensitizer can be used for fluorescence-based diagnosis of UB cancer and treatment of such patients with photodynamic therapy. Application of local fluorescence spectroscopy allows monitoring of photobleaching in the course of treatment session.
Iagudaev
D M
DM
Bulgakova
N N
NN
Sorokatyĭ
A E
AE
Geĭnits
A V
AV
Martov
A G
AG
D002735:Chlorophyllides; D005260:Female; D006801:Humans; D008297:Male; D009092:Mucous Membrane / Q000737:chemistry; D017319:Photosensitizing Agents / Q000032:analysis* / Q000493:pharmacokinetics*; D011166:Porphyrins / Q000032:analysis* / Q000493:pharmacokinetics*; D013050:Spectrometry, Fluorescence; D001743:Urinary Bladder / Q000737:chemistry; D001749:Urinary Bladder Neoplasms / Q000737:chemistry* / Q000378:metabolism
D002735:Chlorophyllides; D017319:Photosensitizing Agents; D011166:Porphyrins; C062985:phytochlorin