title: Enucleation of pancreatic neoplasms.
abstract: BACKGROUND
  Standard resections for benign and borderline neoplasms of the pancreas are associated with a significant risk of long-term functional impairment, whereas enucleation preserves healthy parenchyma and pancreatic function. The aim of this study was to evaluate postoperative and long-term oncological and functional results after pancreatic enucleation.
  
  
  METHODS
  Data collected prospectively from 61 consecutive patients who underwent pancreatic enucleation were analysed.
  
  
  RESULTS
  There were no deaths. A clinically significant pancreatic fistula was reported in 14 patients (23 per cent), and five patients (8 per cent) had a further operation for fistula-related complications. The most common indication for surgery was endocrine neoplasm (38 patients; 62 per cent) and two patients (3 per cent) had a final histopathological diagnosis of malignant neoplasm. At a median follow-up of 61 months no patient had developed tumour recurrence or exocrine insufficiency. Two elderly patients developed non-insulin-dependent diabetes.
  
  
  CONCLUSIONS
  Enucleation is an effective procedure for the radical treatment of benign and borderline neoplasms of the pancreas, with good long-term outcomes.
authors.affiliation: Department of Surgery, Policlinico 'GB Rossi', University of Verona, Piazzale L. A. Scuro 10, 37134 Verona, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Crippa
authors.forename: C
authors.initials: C
authors.lastname: Bassi
authors.forename: R
authors.initials: R
authors.lastname: Salvia
authors.forename: M
authors.initials: M
authors.lastname: Falconi
authors.forename: G
authors.initials: G
authors.lastname: Butturini
authors.forename: P
authors.initials: P
authors.lastname: Pederzoli
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010185:Pancreatic Fistula / Q000209:etiology* / Q000601:surgery; D010190:Pancreatic Neoplasms / Q000601:surgery*; D011183:Postoperative Complications / Q000209:etiology*; D011300:Preoperative Care / Q000379:methods; D011446:Prospective Studies