title: Antiviral and anti-inflammatory effects of rosmarinic acid in an experimental murine model of Japanese encephalitis.
abstract: Rosmarinic acid (RA) reduced the mortality of mice infected with Japanese encephalitis virus (JEV). Significant decreases in viral loads (P < 0.001) and proinflammatory cytokine levels (P < 0.001) were observed in JEV-infected animals treated with RA compared to levels in infected mice without treatment, at 8 to 9 days postinfection.
authors.affiliation: National Brain Research Centre, Manesar, Haryana-122050, India.
authors.forename: Vivek
authors.initials: V
authors.lastname: Swarup
authors.forename: Joydeep
authors.initials: J
authors.lastname: Ghosh
authors.forename: Soumya
authors.initials: S
authors.lastname: Ghosh
authors.forename: Amit
authors.initials: A
authors.lastname: Saxena
authors.forename: Anirban
authors.initials: A
authors.lastname: Basu
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000998:Antiviral Agents; D015153:Blotting, Western; D018925:Chemokines / Q000378:metabolism; D002934:Cinnamates / Q000494:pharmacology*; D016207:Cytokines / Q000378:metabolism; D053630:Depsides / Q000494:pharmacology*; D004664:Encephalitis Virus, Japanese / Q000187:drug effects; D004672:Encephalitis, Japanese / Q000188:drug therapy* / Q000473:pathology / Q000821:virology*; D051379:Mice; D000097123:Rosmarinic Acid
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000998:Antiviral Agents; D018925:Chemokines; D002934:Cinnamates; D016207:Cytokines; D053630:Depsides; D000097123:Rosmarinic Acid