Liver transplantation using non-heart-beating donors: Belgian experience.
Mortality on liver transplantation (OLT) waiting lists has increased dramatically. Until recently, non-heart-beating donors (NHBD) were not considered suitable for OLT, because of a higher risk of primary graft nonfunction (PNF) and biliary strictures. However, recent experimental/clinical evidence has indicated that NHBD-OLT is feasible when the period of warm ischemia is short.


OBJECTIVE
To characterize the results of NHBD-OLT in Belgium, a survey was sent to all Belgian OLT centers.


RESULTS
Between January 2003 and November 2005, 16 livers originating from NHBD were procured and transplanted. The mean donor age was 48.8 years, including 9 males and 7 females with mean time of stop-therapy to cardiac arrest being 18 minutes and from cardiac arrest to liver cold perfusion, 10.5 minutes. Mean recipient age was 52.2 years including 12 males and 4 females. Mean cold ischemia time was 7 hours 15 minutes. No PNF requiring re-OLT was observed. Mean post-OLT peak transaminase was 2209 IU/L, which was higher among imported versus locally procured grafts. Biliary complications occurred in 6 patients requiring re-OLT (n = 2), endoscopic treatment (n = 2), surgical treatment (n = 1), or left untreated (n = 1). These tended to be more frequent after prolonged warm ischemia. Graft and patient survivals were 62.5% and 81.3%, respectively, with a follow-up of 3 to 36 months.


CONCLUSIONS
This survey showed acceptable graft/patient survivals after NHBD-LT. The NHBD-liver grafts suffered a high rate of ischemic injury and biliary complications and therefore should be used carefully, namely with no additional donor risk factors, lower risk recipients, and short cold/warm ischemia.
Monbaliu
D
D
Abdominal Transplant Surgery Department, University Hospitals Leuven, Herestraat 49, B-3000 Leuven, Belgium. Diethard.Monbaliu@uz.kuleuven.ac.be
Van Gelder
F
F
Troisi
R
R
de Hemptinne
B
B
Lerut
J
J
Reding
R
R
de Ville de Goyet
J
J
Detry
O
O
De Roover
A
A
Honore
P
P
Donckier
V
V
Gelin
M
M
Ysebaert
D
D
Aerts
R
R
Coosemans
W
W
Pirenne
J
J
D000328:Adult; D001530:Belgium; D005260:Female; D006323:Heart Arrest; D006801:Humans; D008111:Liver Function Tests; D016031:Liver Transplantation / Q000401:mortality / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016019:Survival Analysis; D014019:Tissue Donors / Q000706:statistics & numerical data; D014850:Waiting Lists