title: [2-octyl-cyanoacrylate in rabbit anophthalmic cavity reconstruction].
abstract: OBJECTIVE
  To evaluate fixation by a bioadhesive of the external ocular muscles to the porous polyethylene spheres.
  
  
  METHODS
  An experimental study was performed using eight white rabbits that underwent right eye enucleation with placement of 12 mm spheres of porous polyethylene. The rectus muscles (superior and inferior) were attached to the implant with a bioadhesive (2-octyl-cyanoacrylate) applied to the inferior side of the external muscles. Ninety days after surgery the orbital content was removed and 4 animals were submitted to a tensile strength test of the muscle-sphere attachment and the other 4 to histological evaluation.
  
  
  RESULTS
  The tensile strength test showed that the rupture force was similar between the muscle and porous polyethylene sphere bond attachment and normal external ocular muscles. The histologic evaluation showed fibrous tissue reaction and muscle-sphere attachment with no deleterious effects to the tissues; a capsule formation around the spheres and new vessels inside the implant were also observed.
  
  
  CONCLUSIONS
  2-octyl-cyanoacrylate provides strength adhesion between muscles and spheres, with surgery time reduction and does not provoke deleterious effects on the orbital tissues. Thus, the bioadhesive might be a good choice for use in the anophthalmic cavity reconstruction.
authors.affiliation: Departamento de Oftalmologia, Otorrinolaringologia e Cirurgia de Cabeça e Pescoço, Faculdade de Medicina, Universidade Estadual Paulista Júlio Mesquita Filho, Botucatu, SP, Brasil.
authors.forename: Lucieni Cristina Barbarini
authors.initials: LC
authors.lastname: Ferraz
authors.forename: Silvana Artioli
authors.initials: SA
authors.lastname: Schellini
authors.forename: Sheila Lordelo
authors.initials: SL
authors.lastname: Wludarski
authors.forename: Carlos Roberto
authors.initials: CR
authors.lastname: Padovani
authors.forename: Sérgio
authors.initials: S
authors.lastname: Müller
mesh_terms: D000818:Animals; D003487:Cyanoacrylates / Q000627:therapeutic use*; D015353:Eye Enucleation; D023421:Models, Animal; D009801:Oculomotor Muscles / Q000187:drug effects* / Q000601:surgery; D009915:Orbit / Q000601:surgery*; D020273:Orbital Implants; D011095:Polyethylenes; D016062:Porosity; D011817:Rabbits; D013718:Tensile Strength / Q000502:physiology; D014014:Tissue Adhesives / Q000627:therapeutic use*
chemical_list: D003487:Cyanoacrylates; D011095:Polyethylenes; D014014:Tissue Adhesives; C100832:octyl 2-cyanoacrylate