Modelling of bioassay data from a Pu wound treated by repeated DTPA perfusions: biokinetics and dosimetric approaches.
The aim of this study is to model plutonium (Pu) excretion from the analysis of a well-documented Pu wound case involving repeated diethylene-triamine-penta-acetic acid (DTPA) perfusions up to 390 d and monitoring up to 3109 d. Three modelling approaches were simultaneously applied involving: (1) release of soluble Pu from the wound, estimated with the ICRP66 dissolution model, (2) systemic behaviour of Pu by using ICRP67 model, but also two new models recently reported and (3) additional 'Pu-DTPA' compartments which transfer Pu directly to urinary compartment from blood, interstitial fluids and liver. The best fit of simulations to biological data was obtained by using the new Leggett's systemic model and assuming the presence of three DTPA compartments. Calculations have shown that DTPA treatments have contributed to a 3-fold reduction of the effective dose. Thus, reduction of doses associated with the DTPA treatments can be estimated by modelling which is useful to improve the efficacy of a DTPA treatment schedule based on a diminution of risk.
Fritsch
P
P
Laboratoire de Radiotoxicologie, SRCA/DRR/DSV/CEA, BP 12, 91680 Bruyères le Châtel, France. paul.fritsch@cea.fr
Grappin
L
L
Guillermin
A M
AM
Fottorino
R
R
Ruffin
M
M
Mièle
A
A
D000328:Adult; D001681:Biological Assay / Q000379:methods*; D001822:Body Burden; D002614:Chelating Agents / Q000008:administration & dosage; D003198:Computer Simulation; D005547:Foreign Bodies / Q000150:complications / Q000178:diet therapy / Q000378:metabolism; D006801:Humans; D007700:Kinetics; D008297:Male; D008657:Metabolic Clearance Rate; D008954:Models, Biological; D004369:Pentetic Acid / Q000008:administration & dosage*; D011005:Plutonium / Q000493:pharmacokinetics* / Q000633:toxicity*; D011832:Radiation Injuries / Q000209:etiology / Q000378:metabolism* / Q000517:prevention & control*; D011837:Radiation-Protective Agents / Q000008:administration & dosage; D011874:Radiometry / Q000379:methods*; D012062:Relative Biological Effectiveness; D016896:Treatment Outcome; D014950:Wounds, Penetrating / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism*
D002614:Chelating Agents; D011837:Radiation-Protective Agents; D011005:Plutonium; D004369:Pentetic Acid