Cerebrosides and tocopherol trimers from the seeds of Euryale ferox.
Two new cerebrosides, ferocerebrosides A (1) [(2S,3R,4E,8E,2'R)-1-O-(beta-glucopyranosyl)-N-(2'-hydroxydocosanoyl)-4,8-sphingadienine] and B (2) [(2S,3R,4E,8E,2'R)-1-O-(beta-glucopyranosyl)-N-(2'-hydroxytetracosanoyl)-4,8-sphingadienine], two new tocopherol trimers, ferotocotrimers C (5) and D (6), and two known tocopherol trimers, IVb (3) and IVa (4), were isolated from the seeds of Euryale ferox. Their structures were determined on the basis of spectroscopic data, especially 1D and 2D NMR experiments. Compounds 1 and 2 showed cytotoxicity in the brine shrimp lethality bioassay, with LC50 values of 0.17 and 0.20 mM, respectively.
Row
Lie-Ching
LC
Fiber Research Division, Industrial Technology Research Institute, Hsinchu, Taiwan, 310, Republic of China.
Ho
Jiau-Ching
JC
Chen
Chiu-Ming
CM
D000818:Animals; D001156:Artemia / Q000187:drug effects*; D002554:Cerebrosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D030702:Nymphaeaceae / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry*; D012639:Seeds / Q000737:chemistry; D024505:Tocopherols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D002554:Cerebrosides; D004365:Drugs, Chinese Herbal; D024505:Tocopherols