title: Smoked cocaine self-administration is decreased by modafinil.
abstract: Modafinil has been reported to reduce cocaine use in a clinical sample of infrequent users (2 days/week), but the effects of modafinil on cocaine self-administration in the laboratory have not been studied. The present study investigated the effects of modafinil maintenance on cocaine self-administration by frequent users (4 days/week) under controlled laboratory conditions. During this 48-day double-blind, crossover design study, the effects of modafinil maintenance (0, 200, and 400 mg/day) on response to smoked cocaine (0, 12, 25, and 50 mg) were examined in nontreatment-seeking cocaine-dependent individuals (n=8). Cocaine significantly increased self-administration, subjective-effect ratings, and cardiovascular measures; modafinil at both doses (200 and 400 mg/day) markedly attenuated these effects. These findings agree with data from previous human laboratory and clinical investigations of modafinil as a potential cocaine abuse treatment medication. Thus, our data support the potential of modafinil as a pharmacotherapy for cocaine dependence.
authors.affiliation: Division on Substance Abuse, New York State Psychiatric Institute, Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA. clh42@columbia.edu
authors.forename: Carl L
authors.initials: CL
authors.lastname: Hart
authors.forename: Margaret
authors.initials: M
authors.lastname: Haney
authors.forename: Suzanne K
authors.initials: SK
authors.lastname: Vosburg
authors.forename: Eric
authors.initials: E
authors.lastname: Rubin
authors.forename: Richard W
authors.initials: RW
authors.lastname: Foltin
mesh_terms: D000328:Adult; D001559:Benzhydryl Compounds / Q000097:blood / Q000627:therapeutic use* / Q000652:urine; D001794:Blood Pressure / Q000187:drug effects; D003042:Cocaine / Q000008:administration & dosage* / Q000097:blood; D019970:Cocaine-Related Disorders / Q000188:drug therapy* / Q000523:psychology*; D018592:Cross-Over Studies; D018765:Dopamine Uptake Inhibitors / Q000008:administration & dosage* / Q000097:blood; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D000077408:Modafinil; D018696:Neuroprotective Agents / Q000097:blood / Q000627:therapeutic use* / Q000652:urine; D010147:Pain Measurement; D012646:Self Administration / Q000379:methods; D011795:Surveys and Questionnaires; D013997:Time Factors
chemical_list: D001559:Benzhydryl Compounds; D018765:Dopamine Uptake Inhibitors; D018696:Neuroprotective Agents; D003042:Cocaine; D000077408:Modafinil