Adenoid basal carcinoma arising in the cervical polyp: an immunohistochemical study of stromal cells.
Adenoid basal carcinomas of the uterine cervix are uncommon neoplasms and generally run a favorable clinical course. Although it is well known that these tumors do not evoke the stromal reaction, we immunohistochemically examined a stromal reaction in a case of adenoid basal carcinoma. A 40-year-old woman was found to have a cervical polyp during a medical checkup and underwent polypectomy. Histological examination revealed the finding of adenoid basal carcinoma. Immunohistochemically, a smaller number of CD34-positive and CD31-negative stromal cells, namely fibroblasts, in the stroma of tumor center than in normal cervical stroma were observed. On the other hand, alpha-smooth muscle actin-positive and h-caldesmon-negative stromal cells, namely myofibroblasts, were completely absent in the stroma of tumor center. Finally, our preliminary report suggests that the decrease of CD34-positive fibroblasts in adenoid basal carcinoma may show an early stromal reaction to tumor invasion. Gynecologists and pathologists should bear in mind that adenoid basal carcinoma may arise in a cervical polyp.
Kuroda
Naoto
N
Department of Pathology, Kochi Red Cross Hospital, Kochi, Japan. nkurodakrch@yahoo.co.jp
Hirano
Kohki
K
Ohara
Masahiko
M
Hirouchi
Takashi
T
Mizuno
Keiko
K
Kubo
Ayumi
A
Enzan
Hideaki
H
D000328:Adult; D018952:Antigens, CD34 / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000378:metabolism*; D003528:Carcinoma, Adenoid Cystic / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D018295:Neoplasms, Basal Cell / Q000473:pathology*; D011127:Polyps / Q000473:pathology*; D017154:Stromal Cells / Q000378:metabolism*; D002583:Uterine Cervical Neoplasms / Q000473:pathology*
D018952:Antigens, CD34; D014408:Biomarkers, Tumor