title: Success of sildenafil treatment in neurogenic female sexual dysfunction caused by L5-S1 intervertebral disk rupture: a case report.
abstract: Female sexual dysfunction can be founded by disorders of sexual desire, arousal, orgasm, and sexual pain. Physiologic sexual dysfunction can, in many cases, be the result of impaired neurovascular tone to the clitoris and vagina. The vagina and clitoris both contain erectile tissue and phosphodiesterase type 5 (PDE5). Accordingly, the use of sildenafil, a PDE5 inhibitor, has been studied in relation to neurogenic female sexual dysfunction. The present case report addresses neurogenic female sexual dysfunction from the result of a ruptured L5-S1 intervertebral disk. The patient was treated with sildenafil, and her symptoms were recorded using a Female Sexual Function Index score. Discussion of the use of sildenafil in women, with an emphasis on female neurovascular sexual physiology and function, is reviewed.
authors.affiliation: Ohio University College of Osteopathic Medicine, Athens, Ohio, USA.
authors.forename: Dean
authors.initials: D
authors.lastname: Ferrara
authors.forename: Stanley
authors.initials: S
authors.lastname: Zaslau
mesh_terms: D000328:Adult; D002987:Clitoris / Q000294:innervation; D005260:Female; D006801:Humans; D007405:Intervertebral Disc Displacement / Q000150:complications*; D008159:Lumbar Vertebrae; D010879:Piperazines / Q000627:therapeutic use*; D011687:Purines / Q000627:therapeutic use; D012421:Rupture; D012447:Sacrum; D012735:Sexual Dysfunction, Physiological / Q000188:drug therapy* / Q000209:etiology*; D000068677:Sildenafil Citrate; D013450:Sulfones / Q000627:therapeutic use*; D014621:Vagina / Q000294:innervation; D014665:Vasodilator Agents / Q000627:therapeutic use*
chemical_list: D010879:Piperazines; D011687:Purines; D013450:Sulfones; D014665:Vasodilator Agents; D000068677:Sildenafil Citrate