[Study of debrisoquine hydroxylation polymorphism (CYP2D6) in the Cuban population compared to Spaniards].
OBJECTIVE
CYP2D6 metabolic capacity shows genetic polymorphism. Two metabolic phenotypes, poor and extensive, can be determined by the ratio of debrisoquine to its metabolite in urine (MR). A subgroup of ultrarapids has been also described. We analyzed the inter-ethnic differences on the polymorphic hydroxylation of debrisoquine in a Cuban population in comparison to Spaniards.


METHODS
MR in a Cuban population of 260 white and mestizo healthy volunteers was studied and compared to 925 Spanish healthy volunteers.


RESULTS
The frequency of poor metabolizer in Cubans (4.6%) was almost identical to that found in Spaniards (4.9%). However, ultrarapids were lower in Cubans (3.8%) than in Spaniards (5.2%). MR in Cuban-mestizo extensive metabolizers was higher than in white (p<0.05).


CONCLUSIONS
Interethnic differences on debrisoquine hydroxylation have been demonstrated in a Cuban population. Furthermore, differences on the frequency of ultrarapids between Cubans and Spaniards have been shown. These results could explain inter-individual and interethnic differences on drug response such as side effects or therapeutic failures among Cuban patients receiving treatment with CYP2D6 substrates.
González
Idilio
I
Hospital Psiquiátrico de La Habana, La Habana, Cuba, and Facultad de Medicina, Universidad de Extremadura, Centro de Investigación Clínica CICAB. idilio@unex.es
Pérez
Bárbaro
B
Alvarez
Mayra
M
Dorado
Pedro
P
Llerena
Adrián
A
D000293:Adolescent; D000328:Adult; D003462:Cuba; D019389:Cytochrome P-450 CYP2D6 / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D013030:Spain
D019389:Cytochrome P-450 CYP2D6