Choline administration: modification of the central actions of atropine.
The anticholinergic agent atropine decreases acetylcholine concentrations and increases high-affinity choline uptake in cortical and hippocampal regions of rat brain. Administration of choline 1 hour before atropine prevents both of these atropine-induced alterations. These findings suggest that alterations in acetylcholine precursor availability may modify the effects of centrally active anticholinergic agents.
Wecker
L
L
Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA.
Dettbarn
W D
WD
Schmidt
D E
DE
D000109:Acetylcholine / Q000378:metabolism*; D000818:Animals; D001285:Atropine / Q000494:pharmacology*; D001692:Biological Transport / Q000187:drug effects; D002794:Choline / Q000008:administration & dosage* / Q000378:metabolism* / Q000494:pharmacology; D018680:Cholinergic Antagonists / Q000494:pharmacology; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008636:Mesencephalon / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012964:Sodium / Q000378:metabolism; D013574:Synaptosomes / Q000187:drug effects / Q000378:metabolism
D018680:Cholinergic Antagonists; D001285:Atropine; D012964:Sodium; D002794:Choline; D000109:Acetylcholine