Population genetics of familial Mediterranean fever: a review.
In this review, some principal population genetic features of familial Mediterranean fever (FMF) are considered. These relate to the time and the place of founder mutations' origins, the role of ancient migrations and contacts between populations in the spatial spreading of the disorder, the influence of environmental factors and cultural traditions on the rate of FMF incidence, and possible selective advantage in carriers of FMF causing gene (MEFV) mutations.
Yepiskoposyan
Levon
L
Institute of Man, Yerevan, Armenia. lepiskop@gmail.com
Harutyunyan
Ashot
A
D003466:Cultural Characteristics; D003598:Cytoskeletal Proteins / Q000235:genetics; D004641:Emigration and Immigration; D004777:Environment; D010505:Familial Mediterranean Fever / Q000235:genetics*; D005828:Genetics, Population; D006579:Heterozygote; D006801:Humans; D009154:Mutation; D000071198:Pyrin; D012641:Selection, Genetic
D003598:Cytoskeletal Proteins; C000604192:MEFV protein, human; D000071198:Pyrin