Fos-like immunoreactivity in Siberian hamster brain during initiation of torpor-like hypothermia induced by 2DG.
Systemic 2-deoxy-d-glucose (2DG) produces pronounced torpor-like hypothermia (not< approximately 15 degrees C) in the Siberian hamster. Siberian hamsters are heterothermic, naturally undergoing photoperiod-dependent torpor during winter-like photoperiods. Fos was used to identify neural structures activated during the initiation of torpor-like hypothermia induced by 2DG treatment. The Fos-like immunoreactivity (Fos-li) in the area postrema and nucleus of the solitary tract that predominantly characterizes other 2DG-induced responses was absent during 2DG-induced torpor in the present experiment. Fos-li was seen in a number of forebrain and hindbrain sites during entry into hypothermia, but the densest Fos-li was found in the parvocellular portion of the paraventricular nucleus. Fos-li in the medial nucleus of the amygdala and the dorsal lateral septum also distinguished 2DG-induced torpor from other 2DG-induced behaviors. The possible involvement of neuropeptide Y pathways during 2DG-induced expression of reversible hypothermia is discussed.
Park
Jin Ho
JH
Department of Psychology, Box 1650, University of California, Berkeley, CA 94720-1650, USA.
Dark
John
J
D000704:Analysis of Variance; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000473:pathology; D002452:Cell Count / Q000379:methods; D006224:Cricetinae; D003847:Deoxyglucose; D005786:Gene Expression Regulation / Q000187:drug effects; D007035:Hypothermia / Q000139:chemically induced* / Q000473:pathology*; D016761:Oncogene Proteins v-fos / Q000378:metabolism*; D017111:Phodopus / Q000502:physiology
D016761:Oncogene Proteins v-fos; D003847:Deoxyglucose