title: Acceleration of luteinizing hormone pulse frequency in adolescent girls with a history of central precocious puberty with versus without hyperandrogenism.
abstract: Some adolescents with a history of idiopathic central precocious puberty (ICPP) develop hyperandrogenism.
  
  
  OBJECTIVE
  Luteinizing hormone (LH) hypersecretion could be a common mechanism underlying ICPP and polycystic ovary syndrome.
  
  
  OBJECTIVE
  To explore the GnRH-LH axis in those patients.
  
  
  METHODS
  To compare overnight LH secretion in 7 healthy adolescents (CG) with that in patients with prior ICPP [5 with (CPPA) and 7 without (CPPB) hyperandrogenism]. To analyze daytime LH secretion in those patients.
  
  
  METHODS
  LH secretion was quantified by immunofluorometry and deconvolution analysis.
  
  
  RESULTS
  Nighttime mean LH (international units/liter) was higher in CPPA (6.9 +/- 1.5) than in CPPB (3.2 +/- 0.4, p < 0.05) and CG (2.9 +/- 0.4, p < 0.01). Deconvolution analysis revealed a greater nighttime LH frequency (pulses/hour) both in CPPA (0.91 +/- 0.06, p < 0.01) and CPPB (0.74 +/- 0.02, p < 0.05) than in CG (0.45 +/- 0.07). CPPA patients maintained a higher frequency than CPPB. Pulsatile LH production was greater in CPPA than in CG (50 +/- 12 vs. 18 +/- 3 IU/l/day, p < 0.01). Daytime mass of LH released per burst and pulsatile production rate were significantly greater in CPPA than in CPPB patients.
  
  
  CONCLUSIONS
  Hyperandrogenic adolescents with prior ICPP show increased pulsatile LH secretion. Augmentation of LH pulsatility may predispose to or cause hyperandrogenism in some adolescents with a history of precocious puberty.
authors.affiliation: Centro de Investigaciones Endocrinológicas (CEDIE), División de Endocrinología, Hospital de Niños Ricardo Gutiérrez, Buenos Aires, Argentina. meugeniaescobar@cedie.org.ar
authors.forename: María Eugenia
authors.initials: ME
authors.lastname: Escobar
authors.forename: María Gabriela
authors.initials: MG
authors.lastname: Ropelato
authors.forename: María Gabriela
authors.initials: MG
authors.lastname: Ballerini
authors.forename: Mirta Graciela
authors.initials: MG
authors.lastname: Gryngarten
authors.forename: María Cecilia García
authors.initials: MC
authors.lastname: Rudaz
authors.forename: Johannes D
authors.initials: JD
authors.lastname: Veldhuis
authors.forename: Marta
authors.initials: M
authors.lastname: Barontini
mesh_terms: D000293:Adolescent; D000735:Androstenedione / Q000097:blood; D004970:Estrone / Q000097:blood; D005260:Female; D015200:Fluoroimmunoassay; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D017588:Hyperandrogenism / Q000150:complications* / Q000378:metabolism*; D007986:Luteinizing Hormone / Q000097:blood* / Q000378:metabolism; D011085:Polycystic Ovary Syndrome / Q000150:complications / Q000378:metabolism; D011629:Puberty, Precocious / Q000150:complications* / Q000378:metabolism*; D013739:Testosterone / Q000097:blood
chemical_list: D004970:Estrone; D013739:Testosterone; D000735:Androstenedione; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone