title: Colistin methanesulfonate against multidrug-resistant Acinetobacter baumannii in an in vitro pharmacodynamic model.
abstract: Using an in vitro pharmacodynamic model, a multidrug-resistant strain of Acinetobacter baumannii was exposed to colistin methanesulfonate alone and in combination with ceftazidime. Pre- and postexposure colistin sulfate MICs were determined. A single daily dose of colistin methanesulfonate combined with continuous-infusion ceftazidime prevented regrowth and postexposure MIC increases.
authors.affiliation: Department of Experimental and Clinical Pharmacology, University of Minnesota College of Pharmacy, 9-157 Weaver-Densford Hall, 308 Harvard Street SE, Minneapolis, MN 55455, USA.
authors.forename: Lisa A
authors.initials: LA
authors.lastname: Kroeger
authors.forename: Laurie B
authors.initials: LB
authors.lastname: Hovde
authors.forename: Isaac F
authors.initials: IF
authors.lastname: Mitropoulos
authors.forename: Jeremy
authors.initials: J
authors.lastname: Schafer
authors.forename: John C
authors.initials: JC
authors.lastname: Rotschafer
mesh_terms: D040981:Acinetobacter baumannii / Q000187:drug effects*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002442:Ceftazidime / Q000494:pharmacology; D003091:Colistin / Q000031:analogs & derivatives* / Q000494:pharmacology; D015169:Colony Count, Microbial; D004338:Drug Combinations; D024901:Drug Resistance, Multiple, Bacterial; D008826:Microbial Sensitivity Tests
chemical_list: D000900:Anti-Bacterial Agents; D004338:Drug Combinations; D002442:Ceftazidime; C004691:colistinmethanesulfonic acid; D003091:Colistin