title: Quercetin inhibits expression of inflammatory cytokines through attenuation of NF-kappaB and p38 MAPK in HMC-1 human mast cell line.
abstract: OBJECTIVE
  Mast cell-mediated allergic inflammation is involved in many diseases such as asthma, sinusitis, and rheumatoid arthritis. Mast cells induce production of pro-inflammatory cytokines with immune regulatory properties. We investigated the effect of quercetin on the expression of pro-inflammatory cytokines in human mast cell line, HMC-1.
  
  
  METHODS
  HMC-1 cells were stimulated with phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187 (PMACI).
  
  
  RESULTS
  Quercetin decreased the gene expression and production of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, IL-6, and IL-8 in PMACI-stimulated HMC-1 cells. Quercetin attenuated PMACI-induced activation of NF-kappaB and p38 mitogen-activated protein kinase.
  
  
  CONCLUSIONS
  Our study provides evidence that quercetin may suitable for the treatment of mast cell-derived allergic inflammatory diseases.
authors.affiliation: Department of Surgery, Chosun University Medical School, Gwangju, 501-759, Republic of Korea.
authors.forename: Y-D
authors.initials: YD
authors.lastname: Min
authors.forename: C-H
authors.initials: CH
authors.lastname: Choi
authors.forename: H
authors.initials: H
authors.lastname: Bark
authors.forename: H-Y
authors.initials: HY
authors.lastname: Son
authors.forename: H-H
authors.initials: HH
authors.lastname: Park
authors.forename: S
authors.initials: S
authors.lastname: Lee
authors.forename: J-W
authors.initials: JW
authors.lastname: Park
authors.forename: E-K
authors.initials: EK
authors.lastname: Park
authors.forename: H-I
authors.initials: HI
authors.lastname: Shin
authors.forename: S-H
authors.initials: SH
authors.lastname: Kim
mesh_terms: D000001:Calcimycin / Q000494:pharmacology; D002273:Carcinogens / Q000494:pharmacology; D002460:Cell Line; D016207:Cytokines / Q000378:metabolism*; D004789:Enzyme Activation / Q000187:drug effects; D006801:Humans; D053583:Interleukin-1beta / Q000378:metabolism; D015850:Interleukin-6 / Q000378:metabolism; D016209:Interleukin-8 / Q000378:metabolism; D007476:Ionophores / Q000494:pharmacology; D008407:Mast Cells / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D016328:NF-kappa B / Q000378:metabolism*; D011794:Quercetin / Q000494:pharmacology*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D048051:p38 Mitogen-Activated Protein Kinases / Q000378:metabolism*
chemical_list: D002273:Carcinogens; D016207:Cytokines; D053583:Interleukin-1beta; D015850:Interleukin-6; D016209:Interleukin-8; D007476:Ionophores; D016328:NF-kappa B; D014409:Tumor Necrosis Factor-alpha; D000001:Calcimycin; D011794:Quercetin; D048051:p38 Mitogen-Activated Protein Kinases; D013755:Tetradecanoylphorbol Acetate