Naturally occurring compounds affect glutamatergic neurotransmission in rat brain.
Natural products, including those derived from plants, have largely contributed to the development of therapeutic drugs. Glutamate is the main excitatory neurotransmitter in the central nervous system and it is also considered a nociceptive neurotransmitter, by acting on peripheral nervous system. For this reason, in this study we investigated the effects of the hydroalcoholic extracts from Drymis winteri (polygodial and drimanial), Phyllanthus (rutin and quercetine), Jathopha elliptica (jatrophone), Hedyosmum brasiliense (13HDS), Ocotea suaveolens (Tormentic acid), Protium kleinii (alphabeta-amyrin), Citrus paradise (naringin), soybean (genistein) and Crataeva nurvala (lupeol), described as having antinociceptive effects, on glutamatergic transmission parameters, such as [(3)H]glutamate binding, [(3)H]glutamate uptake by synaptic vesicles and astrocyte cultures, and synaptosomal [(3)H]glutamate release. All the glutamatergic parameters were affected by one or more of these compounds. Specifically, drimanial and polygodial presented more broad and profound effects, requiring more investigation on their mechanisms. The putative central side effects of these compounds, via the glutamatergic system, are discussed.
Martini
Lucia Helena
LH
Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2600-Anexo, Porto Alegre, RS 90035-003, Brazil.
Jung
Fernanda
F
Soares
Felix Antunes
FA
Rotta
Liane Nanci
LN
Vendite
Deusa Aparecida
DA
Frizzo
Marcos Emilio dos Santos
ME
Yunes
Rosendo A
RA
Calixto
João Batista
JB
Wofchuk
Susana
S
Souza
Diogo O
DO
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D004224:Diterpenes / Q000494:pharmacology; D044950:Flavanones / Q000494:pharmacology; D019833:Genistein / Q000494:pharmacology; D018698:Glutamic Acid / Q000378:metabolism*; D009828:Oleanolic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012717:Sesquiterpenes / Q000494:pharmacology; D009435:Synaptic Transmission / Q000187:drug effects*; D013574:Synaptosomes / Q000187:drug effects / Q000378:metabolism*; D014315:Triterpenes / Q000494:pharmacology
D004224:Diterpenes; D044950:Flavanones; D010936:Plant Extracts; D012717:Sesquiterpenes; D014315:Triterpenes; C469416:drimanial; C006386:jatrophone; D018698:Glutamic Acid; C007695:euscaphic acid; C034380:polygodial; D009828:Oleanolic Acid; D019833:Genistein; C036380:beta-amyrin; C005274:naringin