Glucuronic acid-based ulosyl donors for introducing alpha-D-GlcA and beta-D-ManA units.
Practical protocols are described for a five-step conversion of D-glucuronolactone into alpha-D-arabino-2-ketoglucuronyl bromides, which due to their alpha-selective or beta-specific glycosidation, and gluco- or manno-specific carbonyl reductions of the glucurono-2-ulosides formed, are expedient indirect donor substrates for the efficient introduction of alpha-D-GlcA or beta-D-ManA residues.
Lergenmüller
Matthias
M
Clemens-Schöpf-Institut für Organische Chemie und Biochemie, Technische Universität Darmstadt, D-64287 Darmstadt, Germany.
Lichtenthaler
Frieder W
FW
D005947:Glucose / Q000737:chemistry; D020723:Glucuronic Acid / Q000737:chemistry; D008358:Mannose / Q000737:chemistry; D009844:Oligosaccharides / Q000138:chemical synthesis*
D009844:Oligosaccharides; D020723:Glucuronic Acid; D005947:Glucose; D008358:Mannose