title: Cyclin A expression and its diagnostic value in pleomorphic adenoma and carcinoma expleomorphic adenoma of the parotid gland.
abstract: OBJECTIVE
  To investigate cyclin A expression in pleomorphic adenoma (PA) and carcinoma expleomorphic adenoma (CXPA) of the parotid gland with a view to assessing its potential value as a diagnostic marker for CXPA.
  
  
  RESULTS
  Cyclin A expression in PA and CXPA was studied using semiquantitative immunohistochemistry. The epithelial component of the tumours expressed cyclin A in a statistically significantly (P < 0.005) higher number of CXPA cases (86%) compared with the PA cases (39%). Cyclin A was not expressed in normal salivary tissues of PA and CXPA.
  
  
  CONCLUSIONS
  High cyclin A expression is a useful marker for the pathological diagnosis of CXPA.
authors.affiliation: Sydney Head & Neck Cancer Institute, Sydney Cancer Centre, University of Sydney, Sydney, New South Wales, Australia. dr_rajan_patel@hotmail.com
authors.forename: R S
authors.initials: RS
authors.lastname: Patel
authors.forename: C W
authors.initials: CW
authors.lastname: Hughes
authors.forename: S
authors.initials: S
authors.lastname: Fredericks
authors.forename: C S
authors.initials: CS
authors.lastname: Lee
authors.forename: B
authors.initials: B
authors.lastname: Rose
authors.forename: K
authors.initials: K
authors.lastname: Gao
authors.forename: G
authors.initials: G
authors.lastname: Smith
authors.forename: A
authors.initials: A
authors.lastname: Hong
authors.forename: C J
authors.initials: CJ
authors.lastname: O'Brien
mesh_terms: D008949:Adenoma, Pleomorphic / Q000175:diagnosis* / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000378:metabolism; D016022:Case-Control Studies; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D019925:Cyclin A / Q000235:genetics / Q000378:metabolism*; D003937:Diagnosis, Differential; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D010306:Parotid Gland / Q000378:metabolism / Q000473:pathology; D010307:Parotid Neoplasms / Q000175:diagnosis* / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; D019925:Cyclin A