title: [Perforated gastroduodenal stress ulcer].
abstract: Experimental and clinical data support the role of oxidative stress in the development of gastro-duodenal inflammatory lesions and peptic ulcer. Although quite common, stress ulcer remains a minor concern in the The authors review the literature data and perform a retrospective study on 205 personal cases of gastroduodenal ulcers, diagnosed and operated in the period 1986-2005. Of these, 58 (28.29%) were perforated ulcers, including 4 cases (6.8%) caused by various psychic traumas. All the patients presented symptoms and signs characteristic for perforated ulcer and were undoubtedly of psychogenic cause. The surgical treatment consisted in the closure of the perforation and peritoneal drainage. Besides medical treatment of peptic ulcer disease consisting of antisecretory drugs, antioxidants and sedatives were used. Postoperative follow-up showed a rapid and uneventful recovery in all cases. In conclusion, surgery is the mainstay of treatment in perforated ulcer, but additional stress therapy promotes healing and may reduce postoperative morbidity in cases with certain involvement of psychic trauma.
authors.affiliation: Spitalul Căi Ferate Paşcani, Universitatea de Medicină şi Farmacie Gr. T. Popa IaSi Facultatea de Medicină.
authors.forename: C
authors.initials: C
authors.lastname: Melinte
authors.forename: Cr
authors.initials: C
authors.lastname: Dragomir
mesh_terms: D000328:Adult; D000368:Aged; D000897:Anti-Ulcer Agents / Q000627:therapeutic use; D000975:Antioxidants / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D004381:Duodenal Ulcer / Q000188:drug therapy / Q000601:surgery*; D006801:Humans; D006993:Hypnotics and Sedatives / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010439:Peptic Ulcer Perforation / Q000188:drug therapy / Q000601:surgery*; D012189:Retrospective Studies; D013276:Stomach Ulcer / Q000188:drug therapy / Q000601:surgery*; D016896:Treatment Outcome
chemical_list: D000897:Anti-Ulcer Agents; D000975:Antioxidants; D006993:Hypnotics and Sedatives