Infrared fluorescence endoscopy for the diagnosis of superficial gastric tumors.
BACKGROUND
Indocyanine green (ICG) is a fluorescent marker that is excited by rays at a wavelength of 768 nm to emit fluorescence at a wavelength of 807 nm in the infrared (IR) range. We developed an IR fluorescence endoscope (IRFE) to observe superficial gastric tumors and assessed its clinical usefulness.


OBJECTIVE
To evaluate the clinical usefulness of an IRFE for the assessment of superficial gastric tumors.


METHODS
An observational study.


METHODS
University hospital.


METHODS
Newly developed IRFE.


METHODS
Thirty patients with gastric tumors were enrolled in this study, and their lesions were subjected to endoscopic submucosal dissection (ESD), or laparoscopic gastrectomy after observation with the IRFE.


METHODS
Gastric lesions were subjected to conventional observation, followed by IR fluorescence observation before and after intravenous ICG (0.01 mg/kg) injection.


METHODS
The relationship between the positive fluorescence and invasivity of each tumor.


RESULTS
Fluorescence was positive in 8 of 10 gastric cancers with submucosal invasion (80%) and 1 of 20 adenomas or intramucosal gastric cancers (5%); the difference was statistically significant (P<.01).


CONCLUSIONS
IRFE is a useful diagnostic tool for estimating the invasivity of gastric tumors.
Kimura
Tetsuo
T
Department of Digestive and Cardiovascular Medicine, University of Tokushima Graduate School, Tokushima City, Japan.
Muguruma
Naoki
N
Ito
Susumu
S
Okamura
Seisuke
S
Imoto
Yoshitaka
Y
Miyamoto
Hiroshi
H
Kaji
Masako
M
Kudo
Eiji
E
D000230:Adenocarcinoma / Q000473:pathology* / Q000601:surgery; D000236:Adenoma / Q000473:pathology* / Q000601:surgery; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004396:Coloring Agents; D020776:Endoscopes, Gastrointestinal; D016099:Endoscopy, Gastrointestinal / Q000379:methods*; D004867:Equipment Design; D005260:Female; D005453:Fluorescence; D006801:Humans; D007208:Indocyanine Green; D007259:Infrared Rays; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D013274:Stomach Neoplasms / Q000473:pathology* / Q000601:surgery
D004396:Coloring Agents; D007208:Indocyanine Green