title: No association of MDM2 SNP309 with risk of glioblastoma and prognosis.
abstract: The MDM2 SNP309 variant has been shown to increase MDM2 expression and to be associated with tumor formation. In glioblastomas, the P53/MDM2 pathway is of crucial importance and MDM2 amplification is related to poor prognosis. However, we show here that MDM2 SNP309 is not associated with glioblastoma risk, and is not a prognostic factor.
authors.affiliation: INSERM, U711, Biologie des Interactions Neurones & Glie, Paris 75013, France.
authors.forename: Soufiane
authors.initials: S
authors.lastname: El Hallani
authors.forename: Yannick
authors.initials: Y
authors.lastname: Marie
authors.forename: Ahmed
authors.initials: A
authors.lastname: Idbaih
authors.forename: Mathieu
authors.initials: M
authors.lastname: Rodero
authors.forename: Blandine
authors.initials: B
authors.lastname: Boisselier
authors.forename: Florence
authors.initials: F
authors.lastname: Laigle-Donadey
authors.forename: François
authors.initials: F
authors.lastname: Ducray
authors.forename: Jean-Yves
authors.initials: JY
authors.lastname: Delattre
authors.forename: Marc
authors.initials: M
authors.lastname: Sanson
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000235:genetics*; D001932:Brain Neoplasms / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D016022:Case-Control Studies; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics; D020022:Genetic Predisposition to Disease; D005909:Glioblastoma / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D051736:Proto-Oncogene Proteins c-mdm2 / Q000235:genetics*; D012016:Reference Values; D012307:Risk Factors; D016019:Survival Analysis
chemical_list: D014408:Biomarkers, Tumor; C497206:MDM2 protein, human; D051736:Proto-Oncogene Proteins c-mdm2