title: Treatment of inflammatory myofibroblastic tumor of the chest: the extent of resection.
abstract: BACKGROUND
  Owing to the rarity of inflammatory myofibroblastic tumor, its pathology and clinical course are poorly understood.
  
  
  METHODS
  We performed a retrospective chart review of patients diagnosed with inflammatory myofibroblastic tumor in the chest who underwent surgical resection.
  
  
  RESULTS
  From 1995 to 2006, 15 patients (10 males and 5 females) underwent surgical procedures owing to inflammatory myofibroblastic tumors. The mean age of these patients was 31.3 years (range, 7 months to 61 years). Among them, 13 patients (86.7%) presented with respiratory symptoms such as cough, dyspnea, and hemoptysis. Seven patients presented with the tumor located in the lung parenchyma, 4 in the trachea, 2 in the main bronchus, 1 in the segmental bronchus, and 1 in the chest wall. The diagnosis was confirmed before surgery for only 1 patient (6.3%). The types of operations performed included lobectomies for 4 patients, wedge resections using video-assisted thoracic surgery for 4 patients, tracheal/bronchial resections with end-to-end anastomoses for 6 patients, and chest wall resection for 1 patient. Only 2 patients received adjuvant radiation therapy. We followed up with all patients postoperatively for a mean of 33.3 months (range, 1.2 months to 8.4 years). Fourteen patients were free of local recurrence or distant metastasis during the follow-up period.
  
  
  CONCLUSIONS
  Inflammatory myofibroblastic tumor usually requires surgical resection for both proper diagnosis and adequate treatment. Complete resection and achieving negative margins leads to excellent outcome.
authors.affiliation: Department of Thoracic Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
authors.forename: Hyun Joo
authors.initials: HJ
authors.lastname: Lee
authors.forename: Jin Shun
authors.initials: JS
authors.lastname: Kim
authors.forename: Yong Soo
authors.initials: YS
authors.lastname: Choi
authors.forename: Kwhanmien
authors.initials: K
authors.lastname: Kim
authors.forename: Young Mog
authors.initials: YM
authors.lastname: Shim
authors.forename: Joungho
authors.initials: J
authors.lastname: Han
authors.forename: Jhingook
authors.initials: J
authors.lastname: Kim
mesh_terms: D000293:Adolescent; D000328:Adult; D001982:Bronchial Diseases / Q000601:surgery*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006104:Granuloma, Plasma Cell / Q000601:surgery*; D006801:Humans; D007223:Infant; D008171:Lung Diseases / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D014133:Tracheal Diseases / Q000601:surgery*