title: Systemic inflammation in patients with chronic obstructive pulmonary disease who are colonized with Pneumocystis jiroveci.
abstract: In chronic obstructive pulmonary disease, high levels of airway and systemic inflammatory markers are associated with a faster decrease in lung function. Our study shows that patients colonized by Pneumocystis jiroveci have higher proinflammatory cytokine levels than do noncolonized patients. This suggests that Pneumocystis may play a role in disease progression.
authors.affiliation: Department of Internal Medicine, Virgen del Rocio University Hospital, Seville, Spain.
authors.forename: Enrique J
authors.initials: EJ
authors.lastname: Calderón
authors.forename: Laura
authors.initials: L
authors.lastname: Rivero
authors.forename: Nieves
authors.initials: N
authors.lastname: Respaldiza
authors.forename: Rubén
authors.initials: R
authors.lastname: Morilla
authors.forename: Marco A
authors.initials: MA
authors.lastname: Montes-Cano
authors.forename: Vicente
authors.initials: V
authors.lastname: Friaza
authors.forename: Fernando
authors.initials: F
authors.lastname: Muñoz-Lobato
authors.forename: José M
authors.initials: JM
authors.lastname: Varela
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Medrano
authors.forename: Carmen de la
authors.initials: Cde L
authors.lastname: Horra
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D015169:Colony Count, Microbial; D016207:Cytokines / Q000032:analysis / Q000378:metabolism; D018450:Disease Progression; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism; D008297:Male; D009894:Opportunistic Infections / Q000175:diagnosis* / Q000453:epidemiology / Q000276:immunology; D045363:Pneumocystis carinii / Q000302:isolation & purification*; D011020:Pneumonia, Pneumocystis / Q000175:diagnosis* / Q000453:epidemiology; D011379:Prognosis; D029424:Pulmonary Disease, Chronic Obstructive / Q000453:epidemiology / Q000276:immunology / Q000382:microbiology*; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index
chemical_list: D016207:Cytokines; D018836:Inflammation Mediators