title: First confirmed autochthonous case of human Babesia microti infection in Europe.
abstract: A 42-year-old female patient with acute myeloid leukemia presented with fever and heavy chest pain after her first cycle of specific chemotherapy. Acute myocardial infarction was excluded, but surprisingly, parasitic inclusions in erythrocytes became obvious in Pappenheim and Giemsa-stained peripheral blood smears. The patient did not remember a tick bite but acknowledged having received several blood transfusions in her recent medical history. Suspicion of malaria was ruled out by use of a dip-stick test. The diagnosis of Babesia microti infection was finally established by specific polymerase chain reaction (PCR). Six weeks after initiation of specific treatment, PCR turned negative and a positive immunoflourescence assay (IFA) with an IgG titer of 1:128 indicated seroconversion. Subsequent screening of donors involved in the transfusion of blood products to the patient demonstrated borderline reactivity for Babesia microti (IgG-titer 1:32) in 1 out of 44 individuals. Neither the patient nor the positively tested blood donor had travelled to North America or Asia. Therefore, this is the first confirmed autochthonous human infection in Europe.
authors.affiliation: Institute of Medical Microbiology, Friedrich Schiller University, Semmelweiss Str. 4, 07743, Jena, Germany. anke.hildebrandt@med.uni-jena.de
authors.forename: A
authors.initials: A
authors.lastname: Hildebrandt
authors.forename: K-P
authors.initials: KP
authors.lastname: Hunfeld
authors.forename: M
authors.initials: M
authors.lastname: Baier
authors.forename: A
authors.initials: A
authors.lastname: Krumbholz
authors.forename: S
authors.initials: S
authors.lastname: Sachse
authors.forename: T
authors.initials: T
authors.lastname: Lorenzen
authors.forename: M
authors.initials: M
authors.lastname: Kiehntopf
authors.forename: H-J
authors.initials: HJ
authors.lastname: Fricke
authors.forename: E
authors.initials: E
authors.lastname: Straube
mesh_terms: D000208:Acute Disease; D000328:Adult; D000818:Animals; D041001:Babesia microti / Q000472:pathogenicity*; D001404:Babesiosis / Q000175:diagnosis* / Q000453:epidemiology / Q000235:genetics; D001782:Blood Donors; D005260:Female; D005663:Furans; D005858:Germany; D006801:Humans; D007951:Leukemia, Myeloid; D013876:Thiophenes; D065227:Transfusion Reaction; D015047:Zoonoses / Q000635:transmission*
chemical_list: C516387:3,4-bis-(2,4,5-trimethyl-thiophen-3-yl)furan-2,5-dione; D005663:Furans; D013876:Thiophenes