Alterations of the sense of self and personality in Parkinson's disease.
OBJECTIVE
We hypothesized that alterations of subcomponents ('harm-avoidance') of personality and the sense of Self in patients with PD would be associated with executive cognitive dysfunction.


METHODS
Thirty-four patients with PD and 17 age-matched controls with chronic disease were assessed with a set of neuropsychologic, personality and mood tests as well as an experimental assessment of the sense of Self.


RESULTS
On personality and self tests, PD patients evidenced higher harm avoidance, lower novelty seeking scores, and lower recall rates of personally experienced events from childhood than controls and this PD personality profile was associated with poor performance on neuropsychologic tests of executive prefrontal function. PD patients, however, did not differ significantly from controls in their subjectively felt congruence between their present Selves and their hoped-for Selves.


CONCLUSIONS
We suggest that harm-avoidance personality and Self-related changes of PD are due, in part, to a memory disorder associated with frontal dysfunction.
McNamara
Patrick
P
Department of Neurology, Boston University School of Medicine, VA Boston Healthcare System, MA 02130, USA. mcnamar@bu.edu
Durso
Raymon
R
Harris
Erica
E
D000339:Affect; D000368:Aged; D000369:Aged, 80 and over; D001362:Avoidance Learning; D003072:Cognition Disorders / Q000209:etiology / Q000523:psychology; D005106:Exploratory Behavior; D005260:Female; D006801:Humans; D008297:Male; D011939:Mental Recall; D008875:Middle Aged; D009483:Neuropsychological Tests; D010300:Parkinson Disease / Q000523:psychology*; D010551:Personality; D010556:Personality Tests; D011594:Psychometrics; D012649:Self Concept