Synthesis of benzothiazole semicarbazones as novel anticonvulsants--the role of hydrophobic domain.
A series of 1,3-benzothiazol-2-yl semicarbazones (1-15) were prepared in satisfactory yield and evaluated for their anticonvulsant, neurotoxicity and other toxicity studies. All the synthesized compounds were in good agreement with elemental and spectral data. Majority of the compounds were active in MES screen. Selected compounds were checked for their lipophilic character.
Siddiqui
Nadeem
N
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hamdard University, Hamdard Nagar, New Delhi 110062, India. nadeems_03@yahoo.co.in
Rana
Arpana
A
Khan
Suroor A
SA
Bhat
Mashooq A
MA
Haque
Syed E
SE
D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D004353:Drug Evaluation, Preclinical; D005260:Female; D008099:Liver / Q000187:drug effects / Q000473:pathology / Q000502:physiology; D008297:Male; D051379:Mice; D009420:Nervous System / Q000187:drug effects; D012664:Semicarbazones / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity
D000927:Anticonvulsants; D012664:Semicarbazones