title: The relationship of breast-feeding, overweight, and asthma in preadolescents.
abstract: BACKGROUND
  Breast-feeding is suggested to be associated with overweight or asthma in children. Overweight and asthma may share common environmental influences of which breast-feeding may be one.
  
  
  OBJECTIVE
  We evaluated whether short duration of exclusive breast-feeding and subsequent overweight were associated with asthma.
  
  
  METHODS
  A nested case-control study included 246 children with pediatric allergist-diagnosed asthma and 477 controls without asthma at age 8 to 10 years. Information on exclusive breast-feeding was obtained from questionnaire data. Overweight at 8 to 10 years of age was defined as body mass index >/=85th percentile of age and sex-specific growth charts. The association between asthma and exclusive breast-feeding <12 weeks plus overweight, adjusted for sex, parental asthma, aboriginal origin, passive smoking at birth, residence location, and family income, was determined in logistic regression analyses.
  
  
  RESULTS
  Exclusive breast-feeding <12 weeks was closely associated with overweight at age 8 to 10 years (P < .001). Exclusive breast-feeding <12 weeks plus overweight was significantly associated with asthma (adjusted OR, 1.81; 95% CI, 1.11-2.95; P = .018). This association appeared to be strong in children whose mothers had asthma (adjusted OR, 3.93; 95% CI, 1.17-13.2) and also in boys (adjusted OR, 2.22; 95% CI, 1.14-4.34). Asthma was not associated with either exclusive breast-feeding <12 weeks or overweight in the absence of the other.
  
  
  CONCLUSIONS
  Short duration of exclusive breast-feeding and subsequent overweight are associated with asthma in susceptible children, suggesting a common pathway.
  
  
  CONCLUSIONS
  This finding adds to the importance of promoting prolonged breast-feeding for the prevention of overweight and asthma.
authors.affiliation: Faculty of Pharmacy, University of Manitoba, Winnipeg, Manitoba, Canada.
authors.forename: Xiao-Mei
authors.initials: XM
authors.lastname: Mai
authors.forename: Allan B
authors.initials: AB
authors.lastname: Becker
authors.forename: Elizabeth A C
authors.initials: EA
authors.lastname: Sellers
authors.forename: Joel J
authors.initials: JJ
authors.lastname: Liem
authors.forename: Anita L
authors.initials: AL
authors.lastname: Kozyrskyj
mesh_terms: D001249:Asthma / Q000453:epidemiology* / Q000209:etiology*; D001942:Breast Feeding; D016022:Case-Control Studies; D002648:Child; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000453:epidemiology; D008297:Male; D050177:Overweight / Q000502:physiology*; D012307:Risk Factors; D013997:Time Factors