RNA helicases--one fold for many functions.
RNA helicases are a large group of enzymes that function in virtually all aspects of RNA metabolism. Although RNA helicases share a highly conserved structure, different enzymes display a wide array of biochemical activities, including RNA duplex unwinding, protein displacement from RNA and strand annealing. Recent structural and functional studies have started to illuminate the mechanisms by which this remarkable diversity of functions can be conducted by the conserved helicase fold.
Jankowsky
Eckhard
E
Department of Biochemistry and Center for RNA Molecular Biology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA. eckhard.jankowsky@case.edu
Fairman
Margaret E
ME
D000818:Animals; D006801:Humans; D017434:Protein Structure, Tertiary; D012313:RNA / Q000378:metabolism*; D020365:RNA Helicases / Q000737:chemistry / Q000502:physiology*
D012313:RNA; D020365:RNA Helicases