title: Finding treasures in frozen cells: new centriole intermediates.
abstract: Centriole duplication has been an area of interest since the late 1800s when Boveri suggested that these structures were central organizers for mitosis and cell division. Two groups12 have delineated a linear pathway for centriole assembly. In C. elegans, Pelletier and coworkers1 have identified intermediates in the pathway using cryo-electron tomography. Surprising, the first intermediate is a hollow tube of 60 nm that increases in diameter and then elongates before acquiring microtubules. Similar structures have not been observed to date in other centrioles.
authors.affiliation: Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA. dutcher@genetics.wustl.edu
authors.forename: Susan K
authors.initials: SK
authors.lastname: Dutcher
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000166:cytology / Q000378:metabolism / Q000648:ultrastructure; D029742:Caenorhabditis elegans Proteins / Q000378:metabolism; D002502:Centrioles / Q000378:metabolism* / Q000648:ultrastructure; D020285:Cryoelectron Microscopy; D008870:Microtubules / Q000378:metabolism* / Q000648:ultrastructure; D008954:Models, Biological
chemical_list: D029742:Caenorhabditis elegans Proteins