title: Rapid-onset type 1 diabetes associated with cytomegalovirus infection and islet autoantibody synthesis.
abstract: We report the case of a 59-year-old woman who developed rapid-onset type 1 diabetes associated with a marked increase in anti-glutamic acid decarboxylase antibody titer (317.5 U/ml), mild increase in HbA1c level (6.8%), diabetic ketoacidosis, and cytomegalovirus enterocolitis. She was a heterozygote for HLA class II DRB1*0901-DQA1*03-DQB1*0303, and she had HLA class I A24, which may have contributed to the rapid beta cell destruction. Based on the putative molecular mimicry of GAD65 by cytomegalovirus antigen, we hypothesize that the type 1 diabetes in this case was associated with cytomegalovirus infection.
authors.affiliation: Department of Endocrinology and Metabolism, Toranomon Hospital, Tokyo.
authors.forename: Keiichiro
authors.initials: K
authors.lastname: Osame
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Takahashi
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Takasawa
authors.forename: Shigeru
authors.initials: S
authors.lastname: Watanabe
authors.forename: Miyako
authors.initials: M
authors.lastname: Kishimoto
authors.forename: Kazuki
authors.initials: K
authors.lastname: Yasuda
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Kaburagi
authors.forename: Koji
authors.initials: K
authors.lastname: Nakanishi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kajio
authors.forename: Mitsuhiko
authors.initials: M
authors.lastname: Noda
mesh_terms: D001323:Autoantibodies / Q000378:metabolism*; D003586:Cytomegalovirus Infections / Q000150:complications* / Q000175:diagnosis / Q000378:metabolism / Q000628:therapy; D003922:Diabetes Mellitus, Type 1 / Q000175:diagnosis / Q000209:etiology* / Q000378:metabolism / Q000628:therapy; D005260:Female; D006801:Humans; D008875:Middle Aged; D016896:Treatment Outcome
chemical_list: D001323:Autoantibodies; C024211:islet cell antibody