Synthesis of substituted 1,2-dihydroquinolines and quinolines from aromatic amines and alkynes by gold(I)-catalyzed tandem hydroamination-hydroarylation under microwave-assisted conditions.
A method to efficiently prepare substituted 1,2-dihydroquinolines and quinolines by Au(I)-catalyzed tandem hydroamination-hydroarylation under microwave irradiation was developed. This method requires short reaction time (10-70 min) and has a broad substrate scope.
Liu
Xin-Yuan
XY
Department of Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong, People's Republic of China.
Ding
Pan
P
Huang
Jie-Sheng
JS
Che
Chi-Ming
CM
D000480:Alkynes / Q000737:chemistry*; D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D006046:Gold / Q000737:chemistry*; D017612:Gold Compounds / Q000737:chemistry; D007202:Indicators and Reagents; D007211:Indoles / Q000737:chemistry; D008872:Microwaves; D011804:Quinolines / Q000138:chemical synthesis*
D000480:Alkynes; D000588:Amines; D017612:Gold Compounds; D007202:Indicators and Reagents; D007211:Indoles; D011804:Quinolines; C057812:indoline; D006046:Gold