title: Influence of aging and menopause on postprandial lipoprotein responses in healthy adult women.
abstract: OBJECTIVE
  To analyze the influence of menopause and age on postprandial lipoprotein responses in healthy adult women.
  
  
  METHODS
  Twenty-seven healthy young and middle-aged pre- and postmenopausal female volunteers aged 21-53 y were enrolled. They ingested OFTT cream(Jomo, Takasaki, Japan). Fasting and postprandial blood samples were obtained for up to 6 h, and serum concentrations of lipoproteins were analyzed.
  
  
  RESULTS
  In the postprandial phase, serum triglycerides(TG), remnant-like particle(RLP)-TG(RLP-TG), RLP-cholesterol(RLP-C), and TG-rich lipoprotein-TG(TRL-TG)concentrations in all groups peaked after 2 h. After 4 h, the TG, RLP-C, RLP-TG and TRL-TG concentrations in the young women returned to the fasting concentrations. However, at 6 h, these parameters in the pre- and postmenopausal women had barely returned to the fasting concentrations.
  
  
  CONCLUSIONS
  The present results suggest that:(1)the magnitude of postprandial TG concentrations is dependent on age, but not on menopause;(2)clearance of remnant lipoproteins is delayed with age in pre- and postmenopausal women compared to young women, and(3)menopause is associated with an increase of RLP-C, but may not influence LDL particle size.
authors.affiliation: Division of Nutrition and Health, School and Graduate School of Life Studies, Sugiyama Jogakuen University, Nagoya, Japan.
authors.forename: Yuka
authors.initials: Y
authors.lastname: Nabeno
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Fukuchi
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Matsutani
authors.forename: Michitaka
authors.initials: M
authors.lastname: Naito
mesh_terms: D000328:Adult; D000375:Aging / Q000502:physiology*; D002784:Cholesterol / Q000097:blood*; D005215:Fasting; D005260:Female; D006801:Humans; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D008593:Menopause / Q000502:physiology*; D008875:Middle Aged; D019518:Postprandial Period; D014280:Triglycerides / Q000097:blood*
chemical_list: D008074:Lipoproteins; D014280:Triglycerides; C112017:remnant-like particle cholesterol; D002784:Cholesterol