title: Extension of antimicrobial treatment in patients with left-sided native valve endocarditis based on elevated C-reactive protein values.
abstract: The aim of this non-randomized study was to investigate whether there is any benefit in the extension of antimicrobial treatment in patients with left-sided native valve endocarditis in whom C-reactive protein levels are still elevated after a standard course of therapy. There was no statistically significant difference in outcome between the group of patients in which treatment was extended in comparison to the group in which treatment was ended at the recommended time. It is unlikely that there is much to gain from extending treatment based on elevated C-reactive protein levels alone.
authors.affiliation: Department of Infectious Diseases, Tropical Medicine & AIDS, Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.
authors.forename: D W M
authors.initials: DW
authors.lastname: Verhagen
authors.forename: J
authors.initials: J
authors.lastname: Hermanides
authors.forename: J C
authors.initials: JC
authors.lastname: Korevaar
authors.forename: P M M
authors.initials: PM
authors.lastname: Bossuyt
authors.forename: R B A
authors.initials: RB
authors.lastname: van den Brink
authors.forename: P
authors.initials: P
authors.lastname: Speelman
authors.forename: J T M
authors.initials: JT
authors.lastname: van der Meer
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D015415:Biomarkers / Q000032:analysis; D002097:C-Reactive Protein / Q000032:analysis*; D004334:Drug Administration Schedule; D004697:Endocarditis, Bacterial / Q000097:blood / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D015415:Biomarkers; D002097:C-Reactive Protein