Autophagy induction rescues toxicity mediated by proteasome inhibition.
The ubiquitin-proteasome and macroautophagy-lysosome pathways are major routes for intracytosolic protein degradation. In many systems, proteasome inhibition is toxic. A Nature article by Pandey et al. shows that this toxicity can be modulated by altering autophagic activity. Their tantalizing results suggest that overexpression of HDAC6 may increase flux through the autophagy pathway, thereby attenuating the toxicity resulting from proteasome inhibition.
Rubinsztein
David C
DC
Department of Medical Genetics, Cambridge Institute for Medical Research, Addenbrooke's Hospital, Cambridge CB2 0XY, UK. dcr1000@cam.ac.uk
D000818:Animals; D001343:Autophagy / Q000187:drug effects / Q000502:physiology*; D004791:Enzyme Inhibitors / Q000633:toxicity*; D015870:Gene Expression / Q000187:drug effects; D006655:Histone Deacetylases / Q000378:metabolism; D006801:Humans; D046988:Proteasome Endopeptidase Complex / Q000502:physiology*; D061988:Proteasome Inhibitors
D004791:Enzyme Inhibitors; D061988:Proteasome Inhibitors; D046988:Proteasome Endopeptidase Complex; D006655:Histone Deacetylases