title: Self-setting properties and in vitro bioactivity of calcium sulfate hemihydrate-tricalcium silicate composite bone cements.
abstract: Self-setting biomaterials are widely used for tissue repair and regeneration. Calcium sulfate hemihydrate has been used for many years as a self-setting biomaterial due to its good setting properties. However, too fast a degradation rate and lack of bioactivity have limited its application in orthopaedic field. Herein, tricalcium silicate was introduced into calcium sulfate hemihydrate (CaSO(4).1/2H(2)O) to form a calcium sulfate hemihydrate-based composite, and its behavior as a cement was studied in comparison with pure calcium sulfate hemihydrate. The results indicated that the workability and setting time of the composite pastes are higher than those of pure CaSO(4).1/2H(2)O, and the composite pastes showed much better short- and long-term mechanical properties than those of pure CaSO(4).1/2H(2)O. Moreover, the biphasic specimens showed significantly improved bioactivity and degradability compared with those of pure CaSO(4).1/2H(2)O, indicating that the composite cements might have a significant clinical advantage over the traditional CaSO(4).1/2H(2)O cement.
authors.affiliation: Biomaterials and Tissue Engineering Research Center, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Dingxi Road, Shanghai 200050, China.
authors.forename: Zhiguang
authors.initials: Z
authors.lastname: Huan
authors.forename: Jiang
authors.initials: J
authors.lastname: Chang
mesh_terms: D000818:Animals; D001843:Bone Cements / Q000737:chemistry* / Q000378:metabolism* / Q000633:toxicity; D017610:Calcium Compounds / Q000737:chemistry* / Q000378:metabolism* / Q000633:toxicity; D002133:Calcium Sulfate / Q000737:chemistry* / Q000378:metabolism* / Q000633:toxicity; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D008422:Materials Testing; D051379:Mice; D008855:Microscopy, Electron, Scanning; D017640:Silicates / Q000737:chemistry* / Q000378:metabolism* / Q000633:toxicity; D014867:Water / Q000737:chemistry*; D014961:X-Ray Diffraction
chemical_list: D001843:Bone Cements; D017610:Calcium Compounds; D017640:Silicates; D014867:Water; C506393:tricalcium silicate; D002133:Calcium Sulfate