Methyl esterification of 15-hydroperoxyabietic acid does not affect the patch-test result in colophonium allergic patients.
Colophonium (gum rosin) consists of numerous compounds. We have previously shown that abietic acid (Fig. 1), the major compound in gum rosin, is oxidized to strong contact allergens at air exposure (1). The most potent allergen identified is 15-hydroperoxyabietic acid (15-HPA, Fig. 1), which was isolated as its methyl ester (Fig. 1) and used for patch testing (2, 3). The aim of this study was to confirm the previous postulate that methyl esterification of the carboxyl group in 15-HPA does not affect the allergenic activity.
Karlberg
Ann-Therese
AT
Department of Chemistry, Dermatochemistry and Skin Allergy, Göteborg University, Göteborg, Sweden. karlberg@chem.gu.se
Bråred-Christensson
Johanna
J
Börje
Anna
A
Harambasic
Elma
E
Matura
Mihàly
M
D045784:Abietanes / Q000737:chemistry*; D000388:Air; D000393:Air Pollutants / Q000737:chemistry; D000485:Allergens; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis*; D004781:Environmental Exposure; D004951:Esterification; D006801:Humans; D008745:Methylation; D010084:Oxidation-Reduction; D010328:Patch Tests; D012116:Resins, Plant
D045784:Abietanes; D000393:Air Pollutants; D000485:Allergens; D012116:Resins, Plant; C055834:15-hydroperoxyabietic acid; C013893:rosin