title: [Changes of pulmonary artery protein kinase C activity in rats with chronic inflammatory pulmonary hypertension].
abstract: OBJECTIVE
  To observe the changes in pulmonary artery protein kinase C (PKC) activity in rats with chronic inflammatory pulmonary hypertension (PHT).
  
  
  METHODS
  Chronic inflammatory PHT was induced in rats with monocrotaline. The PKC activities in the rat pulmonary arteries were measured by radioactive assay during the development of PHT.
  
  
  RESULTS
  With the development of chronic inflammatory PHT, the total and cytosolic fractions of PKC activity in PHT rat pulmonary arteries increased initially with subsequent decrease (Plt;0.05), but the membranous fraction of PKC activity and the membrane-to-cytosol PKC activity ratio increased continuously (P<0.05).
  
  
  CONCLUSIONS
  The up-regulation of PKC activity and the translocation of PKC might be associated with the development of chronic inflammatory PHT in rats.
authors.affiliation: Department of Biochemistry, Dalian Medical University, Dalian 116027, China. dongxu-73@sohu.com
authors.forename: Xu
authors.initials: X
authors.lastname: Dong
authors.forename: Gang
authors.initials: G
authors.lastname: Wang
authors.forename: Huai-liang
authors.initials: HL
authors.lastname: Wang
authors.forename: Xin-hua
authors.initials: XH
authors.lastname: Zhang
authors.forename: Zhi-hong
authors.initials: ZH
authors.lastname: Zong
authors.forename: Jun
authors.initials: J
authors.lastname: Xing
mesh_terms: D000818:Animals; D002908:Chronic Disease; D006976:Hypertension, Pulmonary / Q000139:chemically induced / Q000201:enzymology*; D007249:Inflammation / Q000139:chemically induced / Q000201:enzymology*; D008297:Male; D016686:Monocrotaline; D011493:Protein Kinase C / Q000378:metabolism*; D011651:Pulmonary Artery / Q000201:enzymology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D016686:Monocrotaline; D011493:Protein Kinase C