title: Plasma surfactant protein D levels and the relation to body mass index in a chinese population.
abstract: Surfactant protein D (SP-D) is a member of the collectin family and is an important component of the pulmonary innate host defence. The protein has a widespread distribution in the human body and is present in multiple epithelia, in endothelium and in blood. Various studies have looked at the relationship between serum SP-D levels and pulmonary inflammatory diseases. The SP-D distribution has been most thoroughly described in European populations and appears with a broad range of serum values highly influenced by genetic factors. In the present study, we investigated the plasma SP-D distribution in a Chinese population from the Tai An region comprising 268 individuals. We found that (i) plasma SP-D in the Chinese population was distributed with a median value of 380.2 ng/ml (324.9; 418.7) and a range from 79.4 to 3965.3 ng/ml, (ii) significantly higher plasma SP-D in men than in women, and no significant effect of age, and (iii) a significant inverse association between serum SP-D and body mass index (BMI) (P = 0.012). The data indicate that racial differences in SP-D expression exist as the median plasma SP-D in the Chinese population was approximately two times lower than the median serum SP-D previously measured in a Danish population using the same immuno-assay. The inverse association between serum SP-D and BMI found in the Chinese population indicates that serum SP-D is related to obesity in similar ways in Chinese and Danes.
authors.affiliation: College of Medicine, Shandong University, Ji-nan, ChinaMedicine, Taishan Medical University, Tai-an, ChinaClinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht, The NetherlandsMedical Biotechnology Center, University of Southern Denmark, Odense, Denmark.
authors.forename: X M
authors.initials: XM
authors.lastname: Zhao
authors.affiliation: College of Medicine, Shandong University, Ji-nan, ChinaMedicine, Taishan Medical University, Tai-an, ChinaClinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht, The NetherlandsMedical Biotechnology Center, University of Southern Denmark, Odense, Denmark.
authors.forename: Y P
authors.initials: YP
authors.lastname: Wu
authors.affiliation: College of Medicine, Shandong University, Ji-nan, ChinaMedicine, Taishan Medical University, Tai-an, ChinaClinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht, The NetherlandsMedical Biotechnology Center, University of Southern Denmark, Odense, Denmark.
authors.forename: R
authors.initials: R
authors.lastname: Wei
authors.affiliation: College of Medicine, Shandong University, Ji-nan, ChinaMedicine, Taishan Medical University, Tai-an, ChinaClinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht, The NetherlandsMedical Biotechnology Center, University of Southern Denmark, Odense, Denmark.
authors.forename: H X
authors.initials: HX
authors.lastname: Cai
authors.affiliation: College of Medicine, Shandong University, Ji-nan, ChinaMedicine, Taishan Medical University, Tai-an, ChinaClinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht, The NetherlandsMedical Biotechnology Center, University of Southern Denmark, Odense, Denmark.
authors.forename: I
authors.initials: I
authors.lastname: Tornoe
authors.affiliation: College of Medicine, Shandong University, Ji-nan, ChinaMedicine, Taishan Medical University, Tai-an, ChinaClinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht, The NetherlandsMedical Biotechnology Center, University of Southern Denmark, Odense, Denmark.
authors.forename: J J
authors.initials: JJ
authors.lastname: Han
authors.affiliation: College of Medicine, Shandong University, Ji-nan, ChinaMedicine, Taishan Medical University, Tai-an, ChinaClinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht, The NetherlandsMedical Biotechnology Center, University of Southern Denmark, Odense, Denmark.
authors.forename: Y
authors.initials: Y
authors.lastname: Wang
authors.affiliation: College of Medicine, Shandong University, Ji-nan, ChinaMedicine, Taishan Medical University, Tai-an, ChinaClinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht, The NetherlandsMedical Biotechnology Center, University of Southern Denmark, Odense, Denmark.
authors.forename: P G
authors.initials: PG
authors.lastname: De Groot
authors.affiliation: College of Medicine, Shandong University, Ji-nan, ChinaMedicine, Taishan Medical University, Tai-an, ChinaClinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht, The NetherlandsMedical Biotechnology Center, University of Southern Denmark, Odense, Denmark.
authors.forename: U
authors.initials: U
authors.lastname: Holmskov
authors.affiliation: College of Medicine, Shandong University, Ji-nan, ChinaMedicine, Taishan Medical University, Tai-an, ChinaClinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht, The NetherlandsMedical Biotechnology Center, University of Southern Denmark, Odense, Denmark.
authors.forename: Z L
authors.initials: ZL
authors.lastname: Xia
authors.affiliation: College of Medicine, Shandong University, Ji-nan, ChinaMedicine, Taishan Medical University, Tai-an, ChinaClinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht, The NetherlandsMedical Biotechnology Center, University of Southern Denmark, Odense, Denmark.
authors.forename: G L
authors.initials: GL
authors.lastname: Sorensen
mesh_terms: D000328:Adult; D000367:Age Factors; D044466:Asian People / Q000208:ethnology; D015992:Body Mass Index; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood*; D037663:Pulmonary Surfactant-Associated Protein D / Q000097:blood*; D012737:Sex Factors
chemical_list: D037663:Pulmonary Surfactant-Associated Protein D