[Known gene interactions as implicated in craniofacial development].
Many genes intervening in development, morphogenesis and craniofacial growth have been identified, primarily by the use of mice mutants. We can distinguish two families: the signalling factors and the transcription factors. The latter interact with DNA to activate or to inhibit the expression of other genes. Some of the transcription factors are called homeogenes because they interact with DNA by a sequence of amino acids known as homeobox that has been carefully conserved throughout the course of evolution. Those factors interact, and signalling cascades have been described. Current research projects seek to discern the exact role of each of these genes in craniofacial growth and to develop a better understanding of the interactions between them.
Simon
Yohann c
Yc
Faculté de chirurgie dentaire, Université Paris V, 1 rue Maurice Arnoux, 92120 Montrouge, France. yohann.simon2@libertysurf.fr
Chabre
Claude
C
Lautrou
Alain
A
Berdal
Ariane
A
D000818:Animals; D005801:Genes, Homeobox / Q000235:genetics; D005838:Genotype; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics; D008445:Maxillofacial Development / Q000235:genetics*; D051379:Mice; D008817:Mice, Mutant Strains; D009024:Morphogenesis / Q000235:genetics; D010641:Phenotype; D015398:Signal Transduction / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics
D047908:Intracellular Signaling Peptides and Proteins; D014157:Transcription Factors