A model for glioma cell migration on collagen and astrocytes.
We present a model for the migration of glioma cells on substrates of collagen and astrocytes. The model is based on a cellular automaton where the various dynamical effects are introduced through adequate evolution rules. Using our model, we investigate the role of homotype and heterotype gap junction communication and show that it is possible to reproduce the corresponding experimental migration patterns. In particular, we confirm the experimental findings that inhibition of homotype gap junctions favours migration while heterotype inhibition hinders it. Moreover, the effect of heterotype gap junction inhibition dominates that of homotype inhibition.
Aubert
M
M
IMNC, Universités Paris VII-Paris XI, CNRS, UMR 8165, Bâtiment 104, 91406 Orsay, France. aubert@imnc.in2p3.fr
Badoual
M
M
Christov
C
C
Grammaticos
B
B
D000818:Animals; D001253:Astrocytes / Q000473:pathology; D045744:Cell Line, Tumor; D002465:Cell Movement; D003094:Collagen; D017629:Gap Junctions / Q000473:pathology; D005910:Glioma / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D051379:Mice; D008954:Models, Biological
D003094:Collagen