The impact of birth weight on prostate cancer incidence and mortality in a population-based study of men born in 1913 and followed up from 50 to 85 years of age.
BACKGROUND
Insulin-like growth factor-I (IGF-I) hormone is directly associated with birth weight (BW), and high IGF-I measured in adults is associated with increased risk of prostate cancer (PCA). Whether BW and PCA are related is inconclusive to date.


METHODS
BW and PCA incidence and mortality data for a population-based cohort of 1,436 singleton Swedish men born in 1913 and followed until 85 years of age were obtained.


RESULTS
BW > or = 4,250 g was associated with significantly higher PCA incidence [62% (CI: 4%-151%)] and PCA mortality [82% (CI: 3%-221%)] than BW 3,001-4,249 g, even when other potential effect modifiers were taken into account. The hazards ratio for PCA incidence fell from approximately 3 at age 50 to unity at age 85. Approximately one out of every six PCA incident cases between 50 and 70 years of age could be attributed to BW > or = 4,250 g.


CONCLUSIONS
In the current study PCA incidence and mortality rate appears to increase with BW.
Eriksson
Margaretha
M
Department of Public Health and Caring Sciences, Family Medicine and Clinical Epidemiology Section, Uppsala University, Uppsala, Sweden. margaretha.eriksson@pubcare.uu.se
Wedel
Hans
H
Wallander
Mari-Ann
MA
Krakau
Ingvar
I
Hugosson
Jonas
J
Carlsson
Sture
S
Svärdsudd
Kurt
K
D000368:Aged; D000369:Aged, 80 and over; D001724:Birth Weight; D015331:Cohort Studies; D005500:Follow-Up Studies; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000032:analysis; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000453:epidemiology* / Q000401:mortality; D013548:Sweden / Q000453:epidemiology
D007334:Insulin-Like Growth Factor I