Dopa-responsive pseudo-orthostatic tremor in parkinsonism.
In four patients an inabilitating standing tremor appeared years before that parkinsonian symptoms were evidenced. This tremor was refractory to gabapentin and dramatically responded to Levodopa administration. Its dominant frequency was 6.2 to 6.9 Hz with sporadic subharmonics at 8 to 18 Hz. Three patients were affected by different genetic mutations (Park 2, Park 6, mtDNA deletion) in one no genetic or metabolic alterations could be evidenced. All patients had dopamine transporter abnormalities. We suggest that the term "Pseudo-Orthostatic Tremor" could be used to define this Dopa responsive, 6 to 7 Hz standing tremor.
Thomas
Astrid
A
Department of Oncology and Neuroscience, Neurophysiopathology, University G. D'Annunzio Chieti-Pescara, Italy.
Bonanni
Laura
L
Antonini
Angelo
A
Barone
Paolo
P
Onofrj
Marco
M
D000328:Adult; D004295:Dihydroxyphenylalanine / Q000009:adverse effects*; D015259:Dopamine Agents / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020734:Parkinsonian Disorders / Q000188:drug therapy / Q000235:genetics; D014202:Tremor / Q000139:chemically induced* / Q000145:classification* / Q000235:genetics
D015259:Dopamine Agents; D004295:Dihydroxyphenylalanine