[Perioperative administration of prostaglandin E1 inhibits post-operative serum bilirubin increase and preserves prothrombin time in patients with hepatocellular carcinoma and cirrhosis after laparoscopic microwave coagulation therapy].
BACKGROUND
Laparoscopic microwave coagulation therapy (LMCT) is indicated for the patients with hepatocellular carcinoma, especially when hepatic function is compromised. We retrospectively investigated the effects of perioperative administration of prostaglandin El on post-operative hepatic function in patients receiving LMCT.


METHODS
Patients receiving LMCT for the treatment of hepatocellular carcinoma associated with compensated cirrhosis were included. Prostaglandin El administration was commenced after the induction of general anesthesia, with infusion rate at 0.01-0.02 microg x kg(-1) min(-1). Post-operative changes of serum albumin, serum total bilirubin, ALT, AST, lactate dehydrogenase, serum cholinesterase, platelet count, and percent prothrombin time were serially measured in patients with and without prostaglandin E1 administration.


RESULTS
Perioperative prostaglandin El administration inhibited post-operative serum bilirubin increase and preserved prothrombin time compared to non-treated group.


CONCLUSIONS
It was suggested that prostaglandin El possessed hepatoprotective property in compensated cirrhosis patients with hepatocelluar carcinoma receiving LMCT.
Miura
Yoshihide
Y
Department of Dental Anesthesiology, School of Dentistry, Health Sciences University of Hokkaido, Hokkaido 061-0293.
Nunokawa
Hiroko
H
Iizawa
Kazue
K
Tanaka
Hisao
H
Shinzawa
Haruhide
H
D000527:Alprostadil / Q000008:administration & dosage*; D001663:Bilirubin / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D006528:Carcinoma, Hepatocellular / Q000150:complications / Q000601:surgery*; D004564:Electrocoagulation / Q000379:methods*; D006801:Humans; D010535:Laparoscopy / Q000379:methods*; D008103:Liver Cirrhosis / Q000150:complications / Q000601:surgery*; D008111:Liver Function Tests; D008113:Liver Neoplasms / Q000150:complications / Q000601:surgery*; D008872:Microwaves / Q000627:therapeutic use*; D019990:Perioperative Care; D011184:Postoperative Period; D011517:Prothrombin Time; D012189:Retrospective Studies
D015415:Biomarkers; D000527:Alprostadil; D001663:Bilirubin