title: Evolutionary dynamics of immune-related genes and pathways in disease-vector mosquitoes.
abstract: Mosquitoes are vectors of parasitic and viral diseases of immense importance for public health. The acquisition of the genome sequence of the yellow fever and Dengue vector, Aedes aegypti (Aa), has enabled a comparative phylogenomic analysis of the insect immune repertoire: in Aa, the malaria vector Anopheles gambiae (Ag), and the fruit fly Drosophila melanogaster (Dm). Analysis of immune signaling pathways and response modules reveals both conservative and rapidly evolving features associated with different functional gene categories and particular aspects of immune reactions. These dynamics reflect in part continuous readjustment between accommodation and rejection of pathogens and suggest how innate immunity may have evolved.
authors.affiliation: Division of Cell and Molecular Biology, Faculty of Natural Sciences, Imperial College London, London SW7 2AZ, UK.
authors.forename: Robert M
authors.initials: RM
authors.lastname: Waterhouse
authors.forename: Evgenia V
authors.initials: EV
authors.lastname: Kriventseva
authors.forename: Stephan
authors.initials: S
authors.lastname: Meister
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Xi
authors.forename: Kanwal S
authors.initials: KS
authors.lastname: Alvarez
authors.forename: Lyric C
authors.initials: LC
authors.lastname: Bartholomay
authors.forename: Carolina
authors.initials: C
authors.lastname: Barillas-Mury
authors.forename: Guowu
authors.initials: G
authors.lastname: Bian
authors.forename: Stephanie
authors.initials: S
authors.lastname: Blandin
authors.forename: Bruce M
authors.initials: BM
authors.lastname: Christensen
authors.forename: Yuemei
authors.initials: Y
authors.lastname: Dong
authors.forename: Haobo
authors.initials: H
authors.lastname: Jiang
authors.forename: Michael R
authors.initials: MR
authors.lastname: Kanost
authors.forename: Anastasios C
authors.initials: AC
authors.lastname: Koutsos
authors.forename: Elena A
authors.initials: EA
authors.lastname: Levashina
authors.forename: Jianyong
authors.initials: J
authors.lastname: Li
authors.forename: Petros
authors.initials: P
authors.lastname: Ligoxygakis
authors.forename: Robert M
authors.initials: RM
authors.lastname: Maccallum
authors.forename: George F
authors.initials: GF
authors.lastname: Mayhew
authors.forename: Antonio
authors.initials: A
authors.lastname: Mendes
authors.forename: Kristin
authors.initials: K
authors.lastname: Michel
authors.forename: Mike A
authors.initials: MA
authors.lastname: Osta
authors.forename: Susan
authors.initials: S
authors.lastname: Paskewitz
authors.forename: Sang Woon
authors.initials: SW
authors.lastname: Shin
authors.forename: Dina
authors.initials: D
authors.lastname: Vlachou
authors.forename: Lihui
authors.initials: L
authors.lastname: Wang
authors.forename: Weiqi
authors.initials: W
authors.lastname: Wei
authors.forename: Liangbiao
authors.initials: L
authors.lastname: Zheng
authors.forename: Zhen
authors.initials: Z
authors.lastname: Zou
authors.forename: David W
authors.initials: DW
authors.lastname: Severson
authors.forename: Alexander S
authors.initials: AS
authors.lastname: Raikhel
authors.forename: Fotis C
authors.initials: FC
authors.lastname: Kafatos
authors.forename: George
authors.initials: G
authors.lastname: Dimopoulos
authors.forename: Evgeny M
authors.initials: EM
authors.lastname: Zdobnov
authors.forename: George K
authors.initials: GK
authors.lastname: Christophides
mesh_terms: D000330:Aedes / Q000235:genetics* / Q000276:immunology; D000818:Animals; D000852:Anopheles / Q000235:genetics* / Q000276:immunology; D023181:Antimicrobial Cationic Peptides / Q000502:physiology; D002352:Carrier Proteins / Q000235:genetics / Q000502:physiology; D004331:Drosophila melanogaster / Q000235:genetics / Q000276:immunology; D019143:Evolution, Molecular; D017344:Genes, Insect; D007113:Immunity, Innate / Q000235:genetics*; D019476:Insect Proteins / Q000235:genetics / Q000502:physiology; D007303:Insect Vectors / Q000235:genetics* / Q000276:immunology; D008288:Malaria / Q000635:transmission; D008543:Melanins / Q000378:metabolism; D005810:Multigene Family; D015398:Signal Transduction; D013045:Species Specificity
chemical_list: D023181:Antimicrobial Cationic Peptides; D002352:Carrier Proteins; D019476:Insect Proteins; D008543:Melanins; C118897:peptidoglycan recognition protein