Human population structure detection via multilocus genotype clustering.
BACKGROUND
We describe a hierarchical clustering algorithm for using Single Nucleotide Polymorphism (SNP) genetic data to assign individuals to populations. The method does not assume Hardy-Weinberg equilibrium and linkage equilibrium among loci in sample population individuals.


RESULTS
We show that the algorithm can assign sample individuals highly accurately to their corresponding ethnic groups in our tests using HapMap SNP data and it is also robust to admixed populations when tested with Perlegen SNP data. Moreover, it can detect fine-scale population structure as subtle as that between Chinese and Japanese by using genome-wide high-diversity SNP loci.


CONCLUSIONS
The algorithm provides an alternative approach to the popular STRUCTURE program, especially for fine-scale population structure detection in genome-wide association studies. This is the first successful separation of Chinese and Japanese samples using random SNP loci with high statistical support.
Gao
Xiaoyi
X
Miami Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL 33136, USA. xgao@med.miami.edu
Starmer
Joshua
J
D000465:Algorithms; D044466:Asian People / Q000145:classification / Q000235:genetics*; D016000:Cluster Analysis; D003198:Computer Simulation; D005787:Gene Frequency; D005819:Genetic Markers; D005828:Genetics, Population; D005838:Genotype; D006801:Humans; D008957:Models, Genetic; D020641:Polymorphism, Single Nucleotide
D005819:Genetic Markers