Higher frequency of regulatory T cells in the elderly and increased suppressive activity in neurodegeneration.
The involvement of regulatory T cells (Treg) in autoimmune-disease development has been demonstrated. However, their alteration during ageing and age-related diseases has not been thoroughly investigated yet. Alzheimer (AD) and Parkinson disease (PD), are related to protein-misfolding and are accompanied by neuroinflammation. Since, it has been hypothesized that the neuroinflammation attempts to prevent disease development, we speculated that changes in Treg might affect any relevant immune mechanism. The analysis of Treg from AD and PD patients as well as non-affected individuals, revealed that the frequency of Treg (CD4(+)Foxp3(+)) increases with age and is accompanied by intensified suppressive activity for Treg in patients.
Rosenkranz
Daniela
D
Department of Cellular Neurology, Tübingen, Germany.
Weyer
Sascha
S
Tolosa
Eva
E
Gaenslen
Alexandra
A
Berg
Daniela
D
Leyhe
Thomas
T
Gasser
Thomas
T
Stoltze
Lars
L
D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000276:immunology*; D000544:Alzheimer Disease / Q000276:immunology* / Q000473:pathology*; D015496:CD4-Positive T-Lymphocytes / Q000502:physiology; D016022:Case-Control Studies; D005260:Female; D005434:Flow Cytometry / Q000379:methods; D051858:Forkhead Transcription Factors / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000276:immunology* / Q000473:pathology*; D016176:T-Lymphocyte Subsets; D050378:T-Lymphocytes, Regulatory / Q000502:physiology*
C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors