title: Power in Voxel-based lesion-symptom mapping.
abstract: Lesion analysis in brain-injured populations complements what can be learned from functional neuroimaging. Voxel-based approaches to mapping lesion-behavior correlations in brain-injured populations are increasingly popular, and have the potential to leverage image analysis methods drawn from functional magnetic resonance imaging. However, power is a major concern for these studies, and is likely to vary regionally due to the distribution of lesion locations. Here, we outline general considerations for voxel-based methods, characterize the use of a nonparametric permutation test adapted from functional neuroimaging, and present methods for regional power analysis in lesion studies.
authors.affiliation: Department of Neurology, University of Pennsylvania, PA 19104, USA. kimberg@mail.med.upenn.edu
authors.forename: Daniel Y
authors.initials: DY
authors.lastname: Kimberg
authors.forename: H Branch
authors.initials: HB
authors.lastname: Coslett
authors.forename: Myrna F
authors.initials: MF
authors.lastname: Schwartz
mesh_terms: D001930:Brain Injuries / Q000473:pathology* / Q000503:physiopathology*; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000473:pathology; D016208:Databases, Factual / Q000706:statistics & numerical data; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D012815:Signal Processing, Computer-Assisted; D013223:Statistics as Topic