title: Dietary restriction modulates alpha-synuclein expression in the aging rat cortex and hippocampus.
abstract: Dietary restriction (DR) is one of the promising environmental interventions known to attenuate aging and decrease risk of age-related neurodegenerative disorders. The aim of this study was to assess the effects of DR on expression of alpha-synuclein, a presynaptic protein involved in pathogenesis of Parkinson's and some other neurodegenerative diseases, in the cortex and hippocampus of adult, middle-aged, late middle-aged, and aged rats. Using Real Time RT-PCR, the authors report that aging regulates the expression of alpha-synuclein in a tissue-specific manner and that long-term DR reverts the late age-related changes of alpha-synuclein expression.
authors.affiliation: Institute for Biological Research, Belgrade, Serbia.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Mladenovic
authors.forename: Milka
authors.initials: M
authors.lastname: Perovic
authors.forename: Nikola
authors.initials: N
authors.lastname: Tanic
authors.forename: Suzana
authors.initials: S
authors.lastname: Petanceska
authors.forename: Sabera
authors.initials: S
authors.lastname: Ruzdijic
authors.forename: Selma
authors.initials: S
authors.lastname: Kanazir
mesh_terms: D000367:Age Factors; D000375:Aging; D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism*; D018753:Diet, Protein-Restricted / Q000379:methods*; D005786:Gene Expression Regulation / Q000502:physiology; D006624:Hippocampus / Q000378:metabolism*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D051844:alpha-Synuclein / Q000378:metabolism*
chemical_list: D051844:alpha-Synuclein