title: Framing the biosocial pathways underlying associations between place and cardiometabolic disease.
abstract: Causal inference regarding the impact of place on health is constrained by limited attention to the biological plausibility of associations. The utility of such evidence also requires demonstrating that place-based exposures precede effects on health. We propose a conceptual framework that integrates time and two plausible biosocial pathways by which the geospatial clustering of social disadvantage might be viewed as causally related to the development of cardiovascular and glycemic disease. The framework distinguishes environmental risk conditions that condition the expression of individual behavioural and psychosocial characteristics, and socioeconomic and material conditions that influence regulatory systems through conscious and non-conscious mechanisms.
authors.affiliation: Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Axe Santé des Populations, 3875 rue Saint-Urbain, Bureau 301, Montreal, Québec, Canada. mark.daniel@umontreal.ca
authors.forename: Mark
authors.initials: M
authors.lastname: Daniel
authors.forename: Spencer
authors.initials: S
authors.lastname: Moore
authors.forename: Yan
authors.initials: Y
authors.lastname: Kestens
mesh_terms: D002318:Cardiovascular Diseases / Q000209:etiology* / Q000378:metabolism; D003210:Concept Formation; D004781:Environmental Exposure / Q000009:adverse effects; D006801:Humans; D011203:Poverty; D011792:Quebec; D012919:Social Behavior; D012931:Social Environment