title: Mood states, sympathetic activity, and in vivo beta-adrenergic receptor function in a normal population.
abstract: The purpose of this study was to examine the relationship between mood states and beta-adrenergic receptor function in a normal population. We also examined if sympathetic nervous system activity is related to mood states or beta-adrenergic receptor function. Sixty-two participants aged 25-50 years were enrolled in this study. Mood states were assessed using the Profile of Mood States (POMS). Beta-adrenergic receptor function was determined using the chronotropic 25 dose isoproterenol infusion test. Level of sympathetic nervous system activity was estimated from 24-hr urine norepinephrine excretion. Higher tension-anxiety, depression-dejection, and anger-hostility were related to decreased beta-adrenergic receptor sensitivity (i.e., higher chronotropic 25 dose values), but tension-anxiety was the only remaining independent predictor of beta-adrenergic receptor function after controlling for age, gender, ethnicity, and body mass index (BMI). Urinary norepinephrine excretion was unrelated to either mood states or beta-adrenergic receptor function. These findings replicate previous reports that anxiety is related to decreased (i.e., desensitized) beta-adrenergic receptor sensitivity, even after controlling for age, gender, ethnicity, and body mass index.
authors.affiliation: Department of Psychiatry, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. bhyu@smc.samsung.co.kr
authors.forename: Bum-Hee
authors.initials: BH
authors.lastname: Yu
authors.forename: Eun-Ho
authors.initials: EH
authors.lastname: Kang
authors.forename: Michael G
authors.initials: MG
authors.lastname: Ziegler
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Mills
authors.forename: Joel E
authors.initials: JE
authors.lastname: Dimsdale
mesh_terms: D000328:Adult; D000339:Affect / Q000502:physiology*; D000786:Anger / Q000502:physiology; D001007:Anxiety / Q000503:physiopathology; D002940:Circadian Rhythm; D003863:Depression / Q000503:physiopathology; D005260:Female; D006791:Hostility; D006801:Humans; D007545:Isoproterenol; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000652:urine; D010555:Personality Inventory; D011943:Receptors, Adrenergic, beta / Q000502:physiology*; D012016:Reference Values; D013564:Sympathetic Nervous System / Q000503:physiopathology*
chemical_list: D011943:Receptors, Adrenergic, beta; D007545:Isoproterenol; D009638:Norepinephrine