Channel-forming activity of alamethicin: effects of covalent tethering.
In this short review article, the effects of covalent tethering of alamethicin molecules on channel-forming behavior are described. Broadly speaking, these chemical modifications have provided insight into all three aspects of channel behavior: the structure of the conducting state, the ion-selectivity and ion-permeation properties, and the voltage dependence. Each of these aspects are discussed in turn.
Woolley
G Andrew
GA
Department of Chemistry, University of Toronto, Toronto, ON, Canada. awoolley@chem.utoronto.ca
D000408:Alamethicin / Q000737:chemistry*; D007473:Ion Channels / Q000737:chemistry*; D011487:Protein Conformation
D007473:Ion Channels; D000408:Alamethicin