title: Synthesis of benzothiazole semicarbazones as novel anticonvulsants--the role of hydrophobic domain.
abstract: A series of 1,3-benzothiazol-2-yl semicarbazones (1-15) were prepared in satisfactory yield and evaluated for their anticonvulsant, neurotoxicity and other toxicity studies. All the synthesized compounds were in good agreement with elemental and spectral data. Majority of the compounds were active in MES screen. Selected compounds were checked for their lipophilic character.
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hamdard University, Hamdard Nagar, New Delhi 110062, India. nadeems_03@yahoo.co.in
authors.forename: Nadeem
authors.initials: N
authors.lastname: Siddiqui
authors.forename: Arpana
authors.initials: A
authors.lastname: Rana
authors.forename: Suroor A
authors.initials: SA
authors.lastname: Khan
authors.forename: Mashooq A
authors.initials: MA
authors.lastname: Bhat
authors.forename: Syed E
authors.initials: SE
authors.lastname: Haque
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D004353:Drug Evaluation, Preclinical; D005260:Female; D008099:Liver / Q000187:drug effects / Q000473:pathology / Q000502:physiology; D008297:Male; D051379:Mice; D009420:Nervous System / Q000187:drug effects; D012664:Semicarbazones / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity
chemical_list: D000927:Anticonvulsants; D012664:Semicarbazones