title: Diterpenoids from Turraeanthus mannii.
abstract: Three new compounds, 15-acetoxy-12-hydroxy-16-methyl-labda-8(17),13E-diene (1), ent-labda-8(17),13-dien-15,16-olid-19-oic acid methyl ester (2), and 12-hydroxy-labda-8(17),13-dien-15,16-olide (3), together with two known compounds, 19-acetoxy-ent-labda-8(17),13-dien-15,16-olide (4), and 16-acetoxy-12,15-epoxy-15beta-hydroxy-labda-8(17),13(16)-diene (5) were isolated from the stem bark of Turraeanthus mannii (Meliaceae). The structures of compounds 1 - 3 were elucidated by analysis of the spectroscopic data. The crude methanol extract and compound 5 exhibited weak antibacterial and antifungal activity.
authors.affiliation: Department of Organic Chemistry, University of Douala, Douala, Cameroon. jucthmas@yahoo.fr
authors.forename: Juliette Catherine
authors.initials: JC
authors.lastname: Vardamides
authors.forename: Valerie Tedjon
authors.initials: VT
authors.lastname: Sielinou
authors.forename: Brigitte
authors.initials: B
authors.lastname: Ndemangou
authors.forename: Augustin Ephrem
authors.initials: AE
authors.lastname: Nkengfack
authors.forename: Zacharias Tanee
authors.initials: ZT
authors.lastname: Fomum
authors.forename: Herve Martial Poumale
authors.initials: HM
authors.lastname: Poumale
authors.forename: Hartmut
authors.initials: H
authors.lastname: Laatsch
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D005591:Chemical Fractionation; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D029582:Meliaceae / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D019906:Nuclear Magnetic Resonance, Biomolecular; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: C495477:16-acetoxy-12(R),15-epoxy-15beta-hydroxylabda-8(17),13(16)-diene; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D004224:Diterpenes; D010936:Plant Extracts