title: Effects of tribromoethanol-medetomidine combination on cycling and ovariectomized Sprague-Dawley rats.
abstract: Although commonly used to induce anesthesia in rodents, the effective dose of tribromoethanol is associated with various side effects. The authors previously found that a tribromoethanol-medetomidine combination reduced the dose of tribromoethanol necessary for effective anesthesia in male Sprague-Dawley rats, an effect reversible by atipamezole. Here, the authors focus on the effect of this anesthetic combination in female Sprague-Dawley rats, its effects on their estrous cycles, and its efficacy at low sex hormone levels. Their results suggest that the anesthetic combination is effective in female rats, does not affect their estrous cycles, and works even when hormone levels are low, such as after ovariectomy.
authors.affiliation: St. Louis Community College, 3400 Pershall Rd., St. Louis, MO 63135, USA. cgopalan@stlcc.edu
authors.forename: Chaya
authors.initials: C
authors.lastname: Gopalan
authors.forename: Ariel S
authors.initials: AS
authors.lastname: Simmons
authors.forename: Giselle K
authors.initials: GK
authors.lastname: Mungal
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Wilson
authors.forename: Margaret
authors.initials: M
authors.lastname: Sieve
authors.forename: Dianne K
authors.initials: DK
authors.lastname: Salem
authors.forename: Mark A
authors.initials: MA
authors.lastname: Rivkin
mesh_terms: D000777:Anesthetics / Q000008:administration & dosage* / Q000009:adverse effects; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004971:Estrus / Q000187:drug effects*; D000431:Ethanol / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D005260:Female; D020926:Medetomidine / Q000008:administration & dosage* / Q000009:adverse effects; D010052:Ovariectomy / Q000662:veterinary; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000777:Anesthetics; C062527:tribromoethanol; D000431:Ethanol; D020926:Medetomidine