Synergism between NF-kappa B1/p50 and Notch2 during the development of marginal zone B lymphocytes.
NF-kappaB1 and Notch2 are both required for the development of marginal zone (MZ) B cells. Analysis of B lymphocyte development in mice that are doubly heterozygous at the Notch2 and NF-kappaB1 loci revealed synergism between Notch2 and NF-kappaB1 during MZ B cell development. Two known transcriptional targets of the Notch pathway, Hes-5 and Deltex-1, were found to be preferentially expressed in MZ B cells and regulated by NF-kappaB1. These studies provide in vivo evidence for a genetic interaction between the Notch and NF-kappaB pathways.
Moran
Stewart T
ST
Cancer Center, Massachusetts General Hospital, Harvard Medical Scool, 13th Street, Charlestown, MA 02129, USA.
Cariappa
Annaiah
A
Liu
Haoyuan
H
Muir
Beth
B
Sgroi
Dennis
D
Boboila
Cristian
C
Pillai
Shiv
S
D000077329:Agammaglobulinaemia Tyrosine Kinase; D000818:Animals; D016175:B-Lymphocyte Subsets / Q000201:enzymology / Q000276:immunology* / Q000378:metabolism* / Q000473:pathology; D051792:Basic Helix-Loop-Helix Proteins / Q000096:biosynthesis / Q000235:genetics; D002450:Cell Communication / Q000235:genetics / Q000276:immunology*; D002454:Cell Differentiation / Q000235:genetics / Q000276:immunology*; D004268:DNA-Binding Proteins / Q000096:biosynthesis / Q000235:genetics; D004789:Enzyme Activation / Q000276:immunology; D005786:Gene Expression Regulation / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D018345:Mice, Knockout; D052002:NF-kappa B p50 Subunit / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D051883:Receptor, Notch2 / Q000502:physiology*; D012097:Repressor Proteins / Q000096:biosynthesis / Q000235:genetics; D015398:Signal Transduction / Q000276:immunology; D013154:Spleen / Q000276:immunology* / Q000378:metabolism* / Q000473:pathology; D044767:Ubiquitin-Protein Ligases
D000077329:Agammaglobulinaemia Tyrosine Kinase; D051792:Basic Helix-Loop-Helix Proteins; D004268:DNA-Binding Proteins; D052002:NF-kappa B p50 Subunit; D011505:Protein-Tyrosine Kinases; D051883:Receptor, Notch2; D012097:Repressor Proteins; D044767:Ubiquitin-Protein Ligases; C489685:Hes5 protein, mouse; C497765:Notch2 protein, mouse; C104035:Dtx1 protein, mouse