Antinociceptive activity of Maytenus rigida stem bark.
Ethanol extract of Maytenus rigida stem bark and its fractions were assessed for antinociceptive activity in tail-flick test in rats. The activity was located in the chloroform, ethyl acetate and aq.methanol fractions. Phytochemical screening revealed that catechin was the only common class of compounds present on the ethanol extract as well as on the active fractions. 4'-Methylepigallocatechin, isolated from the ethyl acetate and aq.methanol fractions, showed antinociceptive effect in the tail-flick test (75 mg/kg; p.o.), which was reversed by the opiate antagonist naloxone (3 mg/kg; i.p.).
Dias
Kellyane S
KS
Departamento de Fisiologia, Laboratório de Farmacologia/Universidade Federal de Sergipe, 49160-000, São Cristóvão /SE, Brazil. kellyanesdias@yahoo.com.br
Marques
Maxsuel S
MS
Menezes
Igor A C
IA
Santos
Thiago C
TC
Silva
Aline B L
AB
Estevam
Charles S
CS
Sant'Ana
Antônio E G
AE
Pizza
Cosimo
C
Antoniolli
Angelo R
AR
Marçal
Rosilene M
RM
D000700:Analgesics / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D004305:Dose-Response Relationship, Drug; D006358:Hot Temperature; D008297:Male; D029755:Maytenus; D010146:Pain / Q000517:prevention & control*; D010147:Pain Measurement / Q000187:drug effects; D008517:Phytotherapy; D024301:Plant Bark; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018547:Plant Stems; D051381:Rats; D017208:Rats, Wistar
D000700:Analgesics; D010936:Plant Extracts