Chromatin crosstalk in development and disease: lessons from REST.
Protein complexes that contain chromatin-modifying enzymes have an important role in regulating gene expression. Recent studies have shown that a single transcription factor, the repressor element 1-silencing transcription factor (REST), can act as a hub for the recruitment of multiple chromatin-modifying enzymes, uncovering interdependencies among individual enzymes that affect gene regulation. Research into the function of REST and its corepressors has provided novel insight into how chromatin-modifying proteins cooperate, and how alterations in this function cause disease. These mechanisms will be relevant to the combinatorial functioning of modular transcriptional regulators that work together to regulate a common promoter; they should also identify targets for potential therapies for a range of human diseases.
Ooi
Lezanne
L
Institute of Membrane & Systems Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK. l.ooi@leeds.ac.uk
Wood
Ian C
IC
D000818:Animals; D001665:Binding Sites; D002843:Chromatin / Q000502:physiology*; D004827:Epilepsy / Q000235:genetics; D005786:Gene Expression Regulation; D020868:Gene Silencing; D016147:Genes, Tumor Suppressor; D006657:Histones / Q000378:metabolism; D006801:Humans; D008969:Molecular Sequence Data; D022661:RNA, Untranslated / Q000378:metabolism; D018085:Regulon; D012097:Repressor Proteins / Q000502:physiology*; D014157:Transcription Factors / Q000502:physiology*; D000099229:RE1-Silencing Transcription Factor
D002843:Chromatin; D006657:Histones; D022661:RNA, Untranslated; D012097:Repressor Proteins; D014157:Transcription Factors; D000099229:RE1-Silencing Transcription Factor