Imbalance in seminal fluid MIF indicates male infertility.
Macrophage migration inhibitory factor (MIF) is a ubiquitous cytokine that functions in reproduction and plays an important role in sperm maturation and motility. Here we reveal a correlation between MIF levels in human seminal fluid and fertility status. We identify an abnormal biphasic profile of MIF in the seminal fluid of patients with impaired sperm parameters. Our findings may be of interest for the development of a diagnostic method for fertility status.
Aljabari
Bayan
B
Laboratory of Medicinal Chemistry, The Feinstein Institute for Medical Research, Manhasset, NY 11030, USA.
Calogero
Aldo E
AE
Perdichizzi
Anna
A
Vicari
Enzo
E
Karaki
Raja
R
Lahloub
Tarek
T
Zatari
Rashed
R
El-Abed
Khaleel
K
Nicoletti
Ferdinando
F
Miller
Edmund J
EJ
Pavlov
Valentin A
VA
Al-Abed
Yousef
Y
D017304:Annexin A5 / Q000378:metabolism; D017209:Apoptosis / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007202:Indicators and Reagents / Q000378:metabolism; D007248:Infertility, Male; D008263:Macrophage Migration-Inhibitory Factors / Q000378:metabolism* / Q000494:pharmacology; D008297:Male; D011419:Propidium / Q000378:metabolism; D012661:Semen / Q000378:metabolism*; D013081:Sperm Motility / Q000187:drug effects; D013094:Spermatozoa / Q000187:drug effects
D017304:Annexin A5; D007202:Indicators and Reagents; D008263:Macrophage Migration-Inhibitory Factors; D011419:Propidium