The effect of sesamol on systemic oxidative stress and hepatic dysfunction in acutely iron-intoxicated mice.
This study investigated the effect of sesamol (3,4-methylenedioxyphenol) on systemic oxidative stress and hepatic function in acutely iron-intoxicated mice. Sesamol reduced the levels of lipid peroxidation, hydroxyl radical, iron production and superoxide anion generation, and xanthine oxidase activity in iron-intoxicated mice. In addition, sesamol decreased the serum levels of aspartate aminotransferase and alanine aminotransferase, and ameliorated iron-intoxication-induced histological changes in the liver. In summary, sesamol might attenuate systemic oxidative stress by reducing xanthine oxidase and improving hepatic function in iron-intoxicated mice.
Hsu
Dur-Zong
DZ
Department of Environmental and Occupational Health, National Cheng Kung University Medical College, Tainan, Taiwan.
Chien
Se-Ping
SP
Chen
Ke-Ting
KT
Liu
Ming-Yie
MY
D000208:Acute Disease; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001219:Aspartate Aminotransferases / Q000378:metabolism*; D052117:Benzodioxoles / Q000494:pharmacology*; D017665:Hydroxyl Radical / Q000378:metabolism; D007501:Iron / Q000506:poisoning*; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000201:enzymology* / Q000473:pathology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D018384:Oxidative Stress / Q000187:drug effects*; D010636:Phenols / Q000494:pharmacology*; D013481:Superoxides / Q000378:metabolism; D014969:Xanthine Oxidase / Q000378:metabolism*
D000975:Antioxidants; D052117:Benzodioxoles; D010636:Phenols; D013481:Superoxides; D017665:Hydroxyl Radical; C025583:sesamol; D007501:Iron; D014969:Xanthine Oxidase; D001219:Aspartate Aminotransferases