title: [Case of hemoglobinuria following glycerin enema].
abstract: A 57-year-old man with lung tumor was scheduled for right middle lobectomy under general anesthesia. The patient received glycerin enema 2 hours before anesthesia. Anesthesia was induced with propofol, fentanyl, ketamine and vecuronium. After the induction, urine of dark-red color was drained through the urinary catheter. Massive (3+) occult blood and few erythrocytes in the urine sediment were observed. Furthermore, blood analysis showed hemolysis with mild renal dysfunction (Cr 1.3 mg x dl(-1)). Although serum CPK and myoglobin increased, there was no apparent symptom that supported the onset of rhabdomyolysis induced by anesthetics, acute myocardial infarction or malignant hyperthermia. At this time, we noticed that blood sample taken before the induction had been hemolysed. With all the above information in mind, we suspected that the main cause of the hemoglobinuria could be the enema and the surgery was canceled. The patient made a good progress with laboratory data normalized on the 4th postanesthesia day. However, rectal ulcer developed as a possible late complication of the enema. Although it is well-known that glycerin enema could cause hemolysis, renal failure and rectal ulcer, the increase of CPK and myoglobin in serum made the diagnosis difficult from other conditions leading to rhabdomyolysis in this case.
authors.affiliation: Department of Anesthesiology, Hirosaki University School of Medicine, Hirosaki 036-8562.
authors.forename: Shoko
authors.initials: S
authors.lastname: Murakami
authors.forename: Tadanobu
authors.initials: T
authors.lastname: Yasuda
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Kushikata
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hashimoto
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Hirota
mesh_terms: D000768:Anesthesia, General; D003937:Diagnosis, Differential; D004733:Enema / Q000009:adverse effects*; D005990:Glycerol / Q000009:adverse effects*; D006456:Hemoglobinuria / Q000209:etiology*; D006461:Hemolysis; D006801:Humans; D008175:Lung Neoplasms / Q000601:surgery; D008875:Middle Aged; D011013:Pneumonectomy; D012002:Rectal Diseases / Q000139:chemically induced; D012206:Rhabdomyolysis; D014456:Ulcer / Q000139:chemically induced
chemical_list: D005990:Glycerol