Rabbit facial nerve anastomosis with fibrin glue: nerve conduction velocity evaluation.
OBJECTIVE
The aim of this study was to evaluate the use of fibrin glue on nerve anastomosis, and study conduction velocity obtained by surface electrodes.


METHODS
In this experimental model we evaluated nerve conduction velocity differences in the preoperative and postoperative periods, for the left facial nerve of 12 rabbits. Then, we evaluated whether there were correlations between conduction velocity and the number of postoperative regenerated axons. The sectioned nerves were anastomosed with fibrin glue. The muscle action potentials were obtained from surface electrodes. The stimulation electrode was placed immediately before the ear pinna (facial nerve trunk) and the recording surface electrode was placed on the quadratus labii inferioris muscle.


RESULTS
The facial nerve normal conduction velocity mean value was of 36.53 m/sec. On the postoperative period, the mean conduction velocity was approximately 81% of the normal mean value. A significant correlation was not observed between the postoperative conduction velocity and the number of regenerated axons (p=0.146).


CONCLUSIONS
The fibrin glue can be used on nerve anastomosis in this animal model and nerve.
Sandrini
Francisco Aurelio Lucchesi
FA
Bucco-Maxillofacial Surgery and Trauma. FOP, UPE.
Pereira-Júnior
Edwaldo Dourado
ED
Gay-Escoda
Cosme
C
D000714:Anastomosis, Surgical / Q000379:methods; D000818:Animals; D001369:Axons; D002452:Cell Count; D004353:Drug Evaluation, Preclinical; D005154:Facial Nerve / Q000502:physiology / Q000601:surgery*; D015718:Fibrin Tissue Adhesive / Q000627:therapeutic use*; D008297:Male; D023421:Models, Animal; D009416:Nerve Regeneration / Q000502:physiology*; D009431:Neural Conduction / Q000502:physiology*; D011817:Rabbits; D014014:Tissue Adhesives / Q000627:therapeutic use*
D015718:Fibrin Tissue Adhesive; D014014:Tissue Adhesives