Synaptic vesicle dynamics sans dynamin.
The neuron-specific guanosine triphosphatase dynamin 1 has been hypothesized to be critically required for pinching off synaptic vesicles during endocytosis. In a recent publication in Science, Ferguson et al. describe a series of experiments demonstrating an unexpectedly selective requirement of dynamin 1 in synaptic vesicle endocytosis only during high frequency (<10 Hz) stimulation, but not after cessation of the stimulus train.
Klingauf
Jurgen
J
Department of Membrane Biophysics, Max Planck Institute for Biophysical Chemistry, 37077 Goettingen, Germany. j.klingauf@mpi-bpc.mpg.de
D000818:Animals; D004307:Dose-Response Relationship, Radiation; D034284:Dynamin I / Q000378:metabolism*; D004558:Electric Stimulation / Q000379:methods; D004705:Endocytosis / Q000502:physiology* / Q000528:radiation effects; D017711:Nonlinear Dynamics; D013572:Synaptic Vesicles / Q000378:metabolism*
D034284:Dynamin I