Quetiapine attenuates the depressive and anxiolytic-like behavioural changes induced by global cerebral ischemia in mice.
Recently, we have reported that quetiapine, an atypical antipsychotic drug, prevents memory impairment and hippocampus neurodegeneration induced by global cerebral ischemia (GCI). In the present study, we examined the possible effects of quetiapine on other behavioural deficits, including the depressive and anxiolytic-like behavioural consequences of GCI. Mice were treated with quetiapine (5 or 10mg/kg/day; intraperitoneal (i.p.)) for 14 days. On Day 15, the animals were subjected to GCI. GCI resulted in a decrease of striatal tyrosine hydroxylase (TH) immunostaining and induced depressive and anxiolytic-like behavioural changes. The behavioural changes were indicated by a significant increase in the immobility duration in a tail-suspension test, and an increase in the time spent in the light box in a light/dark box test. Pre-administration of quetiapine significantly alleviated the decreased TH immunostaining and attenuated the depressive and anxiolytic-like behavioural changes induced by GCI. These results enhance our understanding about the mechanisms of quetiapine and suggest a wider perspective for the clinical use of quetiapine.
Yan
Bin
B
Neuropsychiatry Research Unit, Department of Psychiatry, College of Medicine, University of Saskatchewan, 103 Wiggins Road, Saskatoon, SK S7N 5E4, Canada.
He
Jue
J
Xu
Haiyun
H
Zhang
Yanbo
Y
Bi
Xiaoying
X
Thakur
Sonia
S
Gendron
Alain
A
Kong
Jiming
J
Li
Xin-Min
XM
D000704:Analysis of Variance; D000818:Animals; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D001007:Anxiety / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D001522:Behavior, Animal / Q000187:drug effects* / Q000502:physiology; D002545:Brain Ischemia / Q000150:complications / Q000378:metabolism / Q000473:pathology; D003863:Depression / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D003987:Dibenzothiazepines / Q000627:therapeutic use*; D004195:Disease Models, Animal; D005106:Exploratory Behavior / Q000187:drug effects; D019417:Hindlimb Suspension / Q000379:methods; D008297:Male; D051379:Mice; D011699:Putamen / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D000069348:Quetiapine Fumarate; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
D014150:Antipsychotic Agents; D003987:Dibenzothiazepines; D000069348:Quetiapine Fumarate; D014446:Tyrosine 3-Monooxygenase