[A possible influence of nutrient factors in the mechanism development of the neurodegenerative diseases--alzheimerrs disease and sprongiform encelphalopathy with people].
The article presents a review of the literature data, as well as the author's experimental observations concerning the role of nutrient components in the development of neurodegenerative diseases of amyloidal nature. In particular, the role of antioxidants in the prevention of the accumulation of oxidized proteins blocking the chaperone system is discussed. A separate section is devoted to the formation of the large amorphous aggregates on the association of caseins with the precursors of amyloidal structures (amyloidal beta peptidel-42 and recombinant prions). A possible role of nutrient factors in the development of the neurodegenerative diseases is discussed.
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D000544:Alzheimer Disease / Q000178:diet therapy / Q000209:etiology* / Q000378:metabolism*; D016229:Amyloid beta-Peptides / Q000378:metabolism; D000975:Antioxidants / Q000378:metabolism; D007562:Creutzfeldt-Jakob Syndrome / Q000178:diet therapy / Q000209:etiology* / Q000378:metabolism*; D004032:Diet / Q000009:adverse effects*; D006801:Humans; D018832:Molecular Chaperones / Q000037:antagonists & inhibitors / Q000378:metabolism; D010084:Oxidation-Reduction; D010446:Peptide Fragments / Q000378:metabolism
D016229:Amyloid beta-Peptides; D000975:Antioxidants; D018832:Molecular Chaperones; D010446:Peptide Fragments