title: Multidrug-induced erythema multiforme.
abstract: Adverse skin reactions to drugs are frequent, with rates of reaction to many commonly used drugs exceeding 1%. We describe a 29-year-old woman admitted with a history of itching, rash, vesicles on her hands and soles, and edema on her tongue and oropharynx after trimethoprim-sulfamethoxazole, ciprofloxacin, methenamine anhydromethylene citrate, piroxicam, azithromycin, and ceftriaxone intake. Erythema multiforme (EM) was diagnosed by skin biopsy after oral challenge with piroxicam. EM lesions reappeared after oral challenge with levofloxacin. Although EM is quite common with trimethoprim-sulfamethoxazole and there are some reports of EM appearing after intake of ciprofloxacin, it has rarely been attributed to piroxicam and no reports have identified levofloxacin as a cause.
authors.affiliation: Department of Chest Diseases, Adult Allergy Unit, Hacettepe University School of Medicine, Sihhiye, Ankara, Turkey. ranaisik@hotmail.com
authors.forename: S R
authors.initials: SR
authors.lastname: Isik
authors.forename: G
authors.initials: G
authors.lastname: Karakaya
authors.forename: G
authors.initials: G
authors.lastname: Erkin
authors.forename: A F
authors.initials: AF
authors.lastname: Kalyoncu
mesh_terms: D000328:Adult; D000890:Anti-Infective Agents / Q000009:adverse effects*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D017963:Azithromycin / Q000009:adverse effects; D002443:Ceftriaxone / Q000009:adverse effects; D002939:Ciprofloxacin / Q000009:adverse effects; D004342:Drug Hypersensitivity / Q000209:etiology* / Q000503:physiopathology; D004892:Erythema Multiforme / Q000139:chemically induced*; D005260:Female; D006801:Humans; D064704:Levofloxacin; D008709:Methenamine / Q000009:adverse effects; D015242:Ofloxacin / Q000009:adverse effects; D010894:Piroxicam / Q000009:adverse effects; D012882:Skin Tests; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000009:adverse effects; D014552:Urinary Tract Infections / Q000188:drug therapy
chemical_list: D000890:Anti-Infective Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D010894:Piroxicam; D002939:Ciprofloxacin; D064704:Levofloxacin; D002443:Ceftriaxone; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D017963:Azithromycin; D015242:Ofloxacin; D008709:Methenamine