Systems biology of embryonic morphogens.
A network of secreted proteins that interact with each other in the extracellular space regulates embryonic morphogenesis. Mathematical modeling offers an excellent opportunity to understand how morphogens signal and self-regenerate pattern.
Plouhinec
Jean-Louis
JL
Howard Hughes Medical Institute and Department of Biological Chemistry University of California, Los Angeles, California 90095-1662, USA.
De Robertis
E M
EM
D000818:Animals; D019521:Body Patterning / Q000235:genetics; D018507:Gene Expression Regulation, Developmental; D006023:Glycoproteins / Q000235:genetics; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics; D008954:Models, Biological; D049490:Systems Biology / Q000379:methods*; D014981:Xenopus / Q000196:embryology* / Q000235:genetics; D029867:Xenopus Proteins / Q000235:genetics
D006023:Glycoproteins; D036341:Intercellular Signaling Peptides and Proteins; D029867:Xenopus Proteins; C109976:szl protein, Xenopus; C054234:chordin