title: Effect of root canal sealers on mouse peritoneal macrophage functions.
abstract: Three root canal filling materials, viz. calcium hydroxide-based cement (Apexit, resin-based cement (AH-plus) and glass-ionomer based material (Ketac Endo) were tested for their influence on several functions of peritoneal macrophages from Balb/c mice. Macrophage functions were evaluated by the adherence, phagocytic, candidacidal and Nitro blue tetrazolium-dye assays. Ketac-Endo enhanced all macrophage functions in the first 2 d (p < or = 0.05), when compared to the positive control, but this effect had changed after 7 and 14 d, causing inhibition of these functions. Other materials suppressed substrate adherence capacity and phagocytosis, while significantly stimulating macrophage microbicidal activity (p < or = 0.05) in a time-dependent manner.
authors.affiliation: Departments of Dental Pathology, Medical Faculty, University of Rijeka, 51 000 Rijeka, Croatia. ivana.brekalo@ri.htnet.hr
authors.forename: I
authors.initials: I
authors.lastname: Brekalo
authors.forename: S
authors.initials: S
authors.lastname: Pezelj-Ribarić
authors.forename: M
authors.initials: M
authors.lastname: Abram
authors.forename: V
authors.initials: V
authors.lastname: Ahel
mesh_terms: D000818:Animals; D002126:Calcium Hydroxide / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects* / Q000254:growth & development; D002448:Cell Adhesion / Q000187:drug effects; D004853:Epoxy Resins / Q000494:pharmacology; D005260:Female; D005899:Glass Ionomer Cements / Q000494:pharmacology; D017737:Macrophages, Peritoneal / Q000187:drug effects* / Q000276:immunology* / Q000502:physiology; D051379:Mice; D008807:Mice, Inbred BALB C; D009580:Nitroblue Tetrazolium / Q000378:metabolism*; D010587:Phagocytosis / Q000187:drug effects; D012387:Root Canal Filling Materials / Q000145:classification / Q000494:pharmacology*
chemical_list: C074418:Apexit; D004853:Epoxy Resins; D005899:Glass Ionomer Cements; C074934:Ketac Endo; D012387:Root Canal Filling Materials; C534916:epoxy resin-based root canal sealer; D009580:Nitroblue Tetrazolium; D002126:Calcium Hydroxide