title: Sertraline, a selective serotonin reuptake inhibitor, affects thirst, salt appetite and plasma levels of oxytocin and vasopressin in rats.
abstract: We investigated the effects of chronic administration of sertraline (SERT; approximately 20 mg kg(-1) day(-1) in drinking water), a selective serotonin reuptake inhibitor, on water and sodium intake and on plasma levels of oxytocin (OT) and vasopressin (AVP) in basal and stimulated conditions. Basal water intake was reduced in SERT-treated rats. After 24 h of water deprivation, rats treated with SERT for 21 days ingested less water than the control rats (9.7 +/- 0.5 versus 20.0 +/- 0.9 ml, respectively, at 300 min after water presentation, P < 0.0001). Subcutaneous injection of 2 m NaCl or isoproterenol evoked a lower dipsogenic response in rats treated with SERT for 21 days. Fluid and food deprivation also induced a weaker dipsogenic response in SERT-treated rats (1.6 +/- 0.5 versus 10.2 +/- 1.2 ml, at 300 min, P < 0.0001) but had no effect on saline intake. Sodium depletion induced a higher natriorexigenic response in the SERT group (5.6 +/- 1.3 versus 1.2 +/- 0.3 ml, at 300 min, P < 0.0002). Higher urinary density and lower plasma sodium levels were observed after SERT treatment. Sertraline also increased plasma levels of vasopressin and oxytocin (AVP, 2.65 +/- 0.36 versus 1.31 +/- 0.16 pg ml(-1), P < 0.005; OT, 17.16 +/- 1.06 versus 11.3 +/- 1.03 pg ml(-1), P < 0.0009, at the third week post-treatment). These data constitute the first evidence that chronic SERT treatment affects water and sodium intake in rats. These effects seem to be related to the hyponatraemia caused by the higher plasma levels of AVP and OT.
authors.affiliation: Department of Physiological Sciences, Institute of Biology, UFRuralRJ, Seropédica, RJ, Brazil.
authors.forename: Ana Paula
authors.initials: AP
authors.lastname: de Magalhães-Nunes
authors.forename: Daniel
authors.initials: D
authors.lastname: Badauê-Passos
authors.forename: Renato Rizo
authors.initials: RR
authors.lastname: Ventura
authors.forename: Daniel da Silva
authors.initials: Dda S
authors.lastname: Guedes
authors.forename: Jacqueline Pereira
authors.initials: JP
authors.lastname: Araújo
authors.forename: Priscila Camargo
authors.initials: PC
authors.lastname: Granadeiro
authors.forename: Hevellyn Katarine
authors.initials: HK
authors.lastname: Milanez-Barbosa
authors.forename: Ricardo Henrique
authors.initials: RH
authors.lastname: da Costa-e-Sousa
authors.forename: Magda Alves
authors.initials: MA
authors.lastname: de Medeiros
authors.forename: José
authors.initials: J
authors.lastname: Antunes-Rodrigues
authors.forename: Luís Carlos
authors.initials: LC
authors.lastname: Reis
mesh_terms: D000318:Adrenergic beta-Agonists / Q000494:pharmacology; D000818:Animals; D001066:Appetite / Q000187:drug effects; D004326:Drinking / Q000187:drug effects; D005508:Food Deprivation; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D009997:Osmotic Pressure; D010121:Oxytocin / Q000097:blood*; D051381:Rats; D017208:Rats, Wistar; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology*; D020280:Sertraline / Q000494:pharmacology*; D017673:Sodium Chloride, Dietary / Q000097:blood / Q000494:pharmacology*; D013894:Thirst / Q000187:drug effects*; D014556:Urine; D014667:Vasopressins / Q000097:blood*; D014868:Water Deprivation
chemical_list: D000318:Adrenergic beta-Agonists; D007545:Isoproterenol; D010121:Oxytocin; D017367:Selective Serotonin Reuptake Inhibitors; D020280:Sertraline; D017673:Sodium Chloride, Dietary; D014667:Vasopressins