title: Advanced oxidation protein products, ferrous oxidation in xylenol orange, and malondialdehyde levels in thyroid cancer.
abstract: OBJECTIVE
  The oxidation of protein plays an essential role in the pathogenesis of an important number of degenerative and cancer diseases, which is now widely recognized. The aim is to examine advanced oxidation protein products (AOPPs), lipid peroxidation products malondialdehyde (MDA), and ferrous oxidation in xylenol orange (FOX) in blood samples of papillary thyroid cancer patients compared with healthy controls to determine the oxidation status and the change after thyroidectomy.
  
  
  METHODS
  Thirty-five female thyroid cancer patients who underwent total thyroidectomy and 39 female control subjects were included into this study. Prethyroidectomy and postthyroidectomy, AOPP, FOX, and MDA levels were studied.
  
  
  RESULTS
  Prethyroidectomy AOPP, FOX, and MDA levels were significantly higher compared to control (P < .05). In postthyroidectomy AOPP, FOX, and MDA levels were significantly decreased compared with prethyroidectomy levels (P < .05). However, postthyroidectomy levels on the 20th day were still significantly higher, compared to control subjects (P < .05).
  
  
  CONCLUSIONS
  In conclusion, all of AOPP, FOX, and MDA levels that are markers of protein oxidation and lipid hyperoxidation may induce thyroid cancer development and begin to decrease after thyroidectomy.
authors.affiliation: Department of Biochemistry, Celal Bayar University, Manisa, Turkey. fundakosova@gmail.com
authors.forename: Funda
authors.initials: F
authors.lastname: Kosova
authors.forename: Bahadir
authors.initials: B
authors.lastname: Cetin
authors.forename: Melih
authors.initials: M
authors.lastname: Akinci
authors.forename: Sabahattin
authors.initials: S
authors.lastname: Aslan
authors.forename: Zeki
authors.initials: Z
authors.lastname: Ari
authors.forename: Aylin
authors.initials: A
authors.lastname: Sepici
authors.forename: Nilgün
authors.initials: N
authors.lastname: Altan
authors.forename: Abdullah
authors.initials: A
authors.lastname: çetin
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000097:blood; D001798:Blood Proteins / Q000378:metabolism*; D005260:Female; D005296:Ferrous Compounds / Q000097:blood*; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000097:blood*; D010084:Oxidation-Reduction; D010636:Phenols; D011863:Radioimmunoassay; D018709:Statistics, Nonparametric; D013454:Sulfoxides; D013964:Thyroid Neoplasms / Q000097:blood* / Q000601:surgery; D013965:Thyroidectomy; D014992:Xylenes
chemical_list: D014408:Biomarkers, Tumor; D001798:Blood Proteins; D005296:Ferrous Compounds; D010636:Phenols; D013454:Sulfoxides; D014992:Xylenes; D008315:Malondialdehyde; C016833:xylenol orange