Regulation of pancreatic beta-cell function by adipocytes.
Adipokines, the bioactive factors derived mainly from adipocytes, regulate pancreatic beta-cell function including insulin secretion, gene expression and apoptosis. In this review, we propose that adipokines influence beta-cell function through three interdependent pathways. The first is through regulating lipid and glucose metabolism in beta-cells. The second implicates the change of ion channel opening and closing in beta-cells. The third pathway is via the modification of insulin sensitivity of beta-cells. The endocrine function of adipocytes is dynamic, and the secretion of various adipokines changes under different metabolic conditions. During the progression from the normal state to obesity and to type 2 diabetes, adipokines contribute to the occurrence and development of beta-cell dysfunction in type 2 diabetes.
Zhao
Yu-Feng
YF
Endocrine Cell Biology, Prince Henry's Institute of Medical Research, Melbourne, VIC 3168, Australia.
Chen
Chen
C
D017667:Adipocytes / Q000502:physiology*; D052242:Adiponectin / Q000502:physiology; D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology; D005947:Glucose / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000494:pharmacology; D050417:Insulin-Secreting Cells / Q000502:physiology*; D020738:Leptin / Q000502:physiology; D050356:Lipid Metabolism
D052242:Adiponectin; D007328:Insulin; D020738:Leptin; D005947:Glucose