title: [Aike mixture has good anti-inflammatory and analgesic effects on mice].
abstract: OBJECTIVE
  To study the anti-inflammatory and analgesic actions of Aike Mixture (AKM).
  
  
  METHODS
  A total of 100 male mice were randomly assigned into 5 groups: a normal control group, a drug control group (a hydrocortisone subgroup and an atropine subgroup), a high-dose AKM group, a mid-dose AKM group and a low-dose AKM group. Xylene was spread on the left ear of the experimental mice to induce inflammation, and 1% acetic acid solution injected into the abdominal cavity to produce pain so as to cause the body bend. Different doses of AKM were given and their actions observed.
  
  
  RESULTS
  AKM had obvious anti-inflammatory effect on the xylene-induced ear tumefaction and inhibited the pain-caused body bend in the AKM groups, with significant difference from the normal control (P < 0.01).
  
  
  CONCLUSIONS
  AKM has good anti-inflammatory and analgesic effects, which is of clinical significance in the treatment of chronic prostatitis.
authors.affiliation: Department of Andrology, People's Hospital Affiliated to Fujian College of Traditional Chinese Medicine, Fuzhou, Fujian 350004, China. zmj83@tom.com
authors.forename: Min-jian
authors.initials: MJ
authors.lastname: Zhang
authors.forename: Ke-dan
authors.initials: KD
authors.lastname: Chu
authors.forename: Xin-ling
authors.initials: XL
authors.lastname: Cheng
authors.forename: Xu-dong
authors.initials: XD
authors.lastname: Pan
authors.forename: Wan-jun
authors.initials: WJ
authors.lastname: Cheng
authors.forename: Kai-yuan
authors.initials: KY
authors.lastname: Yu
authors.forename: Yu-hong
authors.initials: YH
authors.lastname: Tan
authors.forename: Jin-zhi
authors.initials: JZ
authors.lastname: Liu
authors.forename: Ya-lei
authors.initials: YL
authors.lastname: Shi
authors.forename: Sheng
authors.initials: S
authors.lastname: Zheng
authors.forename: Qiao-bin
authors.initials: QB
authors.lastname: Liu
mesh_terms: D000818:Animals; D002908:Chronic Disease; D004195:Disease Models, Animal; D004338:Drug Combinations; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D008517:Phytotherapy; D011472:Prostatitis / Q000188:drug therapy*; D012503:Saponins / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D004338:Drug Combinations; D012503:Saponins; D009828:Oleanolic Acid; C025759:saikosaponin D