Co-occurrence of major depression or suicide attempt with migraine with aura and risk for unprovoked seizure.
We hypothesized and found that the co-occurrence of migraine with aura (MA) with major depression (MD) or with suicide attempt (SA) increases the risk for developing unprovoked seizure more than these conditions alone. Number of conditions showed a linear relationship to seizure risk. This may reflect a new condition cluster defined by MA, MD, SA and unprovoked seizures. Identifying the biological underpinnings this cluster may affect clinical diagnosis and treatment.
Hesdorffer
Dale C
DC
The Gertrude H. Sergievsky Center, Columbia University, 630 West 168th Street, P & S Unit 16, New York, NY 10032, USA. dch5@columbia.edu
Lúdvígsson
Pétur
P
Hauser
W Allen
WA
Olafsson
Elías
E
Kjartansson
Olafur
O
D000328:Adult; D000428:Alcohol Drinking / Q000453:epidemiology; D016000:Cluster Analysis; D003865:Major Depressive Disorder / Q000150:complications* / Q000453:epidemiology / Q000523:psychology; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D020325:Migraine with Aura / Q000150:complications* / Q000453:epidemiology / Q000523:psychology; D009483:Neuropsychological Tests; D011569:Psychiatric Status Rating Scales; D012306:Risk; D012307:Risk Factors; D012640:Seizures / Q000150:complications* / Q000453:epidemiology / Q000523:psychology; D013406:Suicide, Attempted / Q000523:psychology* / Q000706:statistics & numerical data