Effect of body mass index on apolipoprotein A-I kinetics in middle-aged men and postmenopausal women.
The effect of body mass index (BMI) and obesity on apolipoprotein (apo) A-I levels and kinetics was examined by gender. Apo A-I kinetics were determined with a primed, constant infusion of deuterated leucine in the fed state in 19 men and 13 postmenopausal women. Compared with nonobese men, nonobese women had a higher level of high-density lipoprotein cholesterol (HDL-C) and apo A-I due to a 48% higher apo A-I production rate (PR) (P = .05). Obesity had no significant effects on apo A-I kinetics in women. In contrast, compared with nonobese men, obese men had a 9% lower apo A-I level due to a 64% higher fractional catabolic rate (FCR) partially offset by a 47% higher PR. Obese women had a 52% higher HDL-C than obese men (50 vs 33 mg/dL, respectively; P = .012), a finding related to the faster apo A-I FCR in obese men. BMI was directly correlated with apo A-I FCR (r = 0.84, P < .001) and PR (r = 0.79, P < .001) in men but not in women. Sixty-two percent of the variability in PR and 71% of the variability in FCR were due to BMI in men and only 3% and 23%, respectively, in women. In conclusion, BMI has a significant effect on apo A-I PR and FCR in men but not in women.
Welty
Francine K
FK
Beth Israel Deaconess Medical Center, Boston, MA 02215, USA. fwelty@bidmc.harvard.edu
Lichtenstein
Alice H
AH
Lamon-Fava
Stefania
S
Schaefer
Ernst J
EJ
Marsh
Julian B
JB
D000328:Adult; D000368:Aged; D016632:Apolipoprotein A-I / Q000096:biosynthesis / Q000097:blood*; D015992:Body Mass Index; D008076:Cholesterol, HDL / Q000097:blood; D005260:Female; D006801:Humans; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood*; D017698:Postmenopause / Q000097:blood
D016632:Apolipoprotein A-I; D008076:Cholesterol, HDL