title: Optimization of intravascular brachytherapy treatment planning in peripheral arteries.
abstract: This work deals with the treatment planning optimization for intravascular brachytherapy (IVB) in peripheral arteries. The objective is both to quantitatively study the validity of different hypotheses required for a reliable application of the treatment with current techniques, and to contribute to the definition and the specification of a new optimized procedure taking into account the actual patient's vessel geometry. The detection of vascular luminal surface was performed by an image analysis process, i.e., virtual active navigation, applied to standard CT data. Dose distribution was calculated according to the formalism proposed and recommended by the AAPM in TG43 and TG60. A method combining simulated annealing and BFGS algorithms was applied to optimize the parameters associated with the dwell points such as their number, positions, and dwell times. Dose-surface histogram (DSH) was used to evaluate the dose distribution results. Four levels of accuracy in target surface description were tested. The application of this optimization method to four different CT data sets including patient data, phantom and animal models showed that the treatment plan can be improved when the actual vessel geometry has been taken into account.
authors.affiliation: LIST, Department of Computer Science and Engineering, Southeast University, Nanjing, China.
authors.forename: Zhengdong
authors.initials: Z
authors.lastname: Zhou
authors.forename: Pascal
authors.initials: P
authors.lastname: Haigron
authors.forename: Huazhong
authors.initials: H
authors.lastname: Shu
authors.forename: Wenxue
authors.initials: W
authors.lastname: Yu
authors.forename: Cécile
authors.initials: C
authors.lastname: Moisan
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Manens
authors.forename: Antoine
authors.initials: A
authors.lastname: Lucas
authors.forename: Limin
authors.initials: L
authors.lastname: Luo
mesh_terms: D000792:Angiography / Q000379:methods*; D001158:Arteries / Q000528:radiation effects*; D001918:Brachytherapy / Q000379:methods*; D003198:Computer Simulation; D020342:Finite Element Analysis; D006801:Humans; D008954:Models, Biological; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods*; D011874:Radiometry / Q000379:methods; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D012062:Relative Biological Effectiveness; D014652:Vascular Diseases / Q000000981:diagnostic imaging* / Q000532:radiotherapy*