Fetal sensitization to cow's milk protein and wheat: cow's milk protein and wheat-specific TNF-alpha production by umbilical cord blood cells and subsequent decline of TNF-alpha production by peripheral blood mononuclear cells following dietary intervention.
We present a case of fetal sensitization to cow's milk protein (CMP) and wheat, resulting in non-IgE mediated food allergy (NFA). Fetal sensitization was indicated by onset of NFA symptoms shortly after birth and CMP/wheat-specific tumor necrosis factor-alpha (TNF-alpha) production by cord blood mononuclear cells. Following dietary intervention, we observed a decline of TNF-alpha production by peripheral blood mononuclear cells with stimuli of these dietary proteins (DPs) but recurrence of reactivity was observed following viral gastroenteritis, while interleukin-10 production with these DPs persisted during his first 5 yr of life. This finding may indicate active suppressive mechanisms for maintaining oral tolerance.
Ward
Carla M
CM
Division of Allergy and Immunology, Department of Pediatrics, UMDNJ-New Jersey Medical School, Newark, NJ 07101-1709, USA.
Geng
Lee
L
Jyonouchi
Harumi
H
D005260:Female; D005312:Fetal Blood / Q000166:cytology / Q000276:immunology; D005333:Fetus; D006801:Humans; D007156:Immunologic Memory; D007231:Infant, Newborn; D007963:Leukocytes, Mononuclear / Q000276:immunology* / Q000378:metabolism; D008297:Male; D016269:Milk Hypersensitivity / Q000276:immunology*; D008894:Milk Proteins / Q000009:adverse effects / Q000276:immunology; D010375:Pedigree; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis*; D021182:Wheat Hypersensitivity / Q000276:immunology*
D008894:Milk Proteins; D014409:Tumor Necrosis Factor-alpha