title: Artificial oxygen carriers: a current review.
abstract: Artificial oxygen carriers are not blood substitutes. They serve to carry oxygen to tissues and are either hemoglobin based or perfluorocarbon based. Driving the development of artificial oxygen carriers are concerns involving both the safety and quantity of the blood supply. No artificial oxygen carriers are currently approved for clinical use in the United States. Hemopure has been approved for use in South Africa. The companies producing Hemopure and PolyHeme, both of which are hemoglobin-based oxygen carriers, have filed a Biologic License Application in the United States. Phase III trials have been completed for Hemopure, while PolyHeme is currently undergoing phase III trials in the PolyHeme Urban Ambulance Trial. No North American trials are under way for perfluorocarbons.
authors.affiliation: Froedtert Hospital, Milwaulkee, Wis, USA. hhenkelhanke@wi.rr.com
authors.forename: Thad
authors.initials: T
authors.lastname: Henkel-Honke
authors.forename: Mark
authors.initials: M
authors.lastname: Oleck
mesh_terms: D001802:Blood Substitutes / Q000494:pharmacology / Q000600:supply & distribution / Q000627:therapeutic use*; D017326:Clinical Trials, Phase III as Topic; D017277:Drug Approval; D005767:Gastrointestinal Diseases / Q000139:chemically induced; D006402:Hematologic Diseases / Q000139:chemically induced; D006454:Hemoglobins / Q000494:pharmacology / Q000600:supply & distribution / Q000627:therapeutic use*; D006801:Humans; D006973:Hypertension / Q000139:chemically induced; D017053:Infection Control; D008708:Methemoglobinemia / Q000139:chemically induced; D020258:Neurotoxicity Syndromes / Q000209:etiology; D009719:Nurse Anesthetists; D010101:Oxygen Consumption / Q000187:drug effects; D017751:Safety Management; D014481:United States; D014486:United States Food and Drug Administration
chemical_list: D001802:Blood Substitutes; D006454:Hemoglobins; C509893:PolyHeme; C096798:HBOC 201