title: Signet-ring cell carcinoma presenting in the uterine cervix: report of a primary and 2 metastatic cases.
abstract: Signet-ring cell carcinoma presenting in the uterine cervix is an uncommon neoplasm. It is usually a metastasis from a primary gastric tumor; only rarely, cervical involvement is the first manifestation of the disease. Primary signet-ring carcinoma of the cervix is extremely unusual, and it is always necessary to rule out a metastatic neoplasm. We report 3 cases of signet-ring cell carcinoma diagnosed in cervical biopsies. All cases were initially considered as metastatic, but a primary site other than the cervix could be confirmed in only 2 cases. Although autopsy was not authorized, a very comprehensive clinical workup and the evolution of the disease support the interpretation of the third case as a primary neoplasm. Primary signet-ring cell carcinoma of the cervix is an extraordinary event-the diagnosis of which requires excluding a metastasis from the gastrointestinal tract (usually the stomach), the ovary, or the breast.
authors.affiliation: Department of Pathology, University and Medical School, Santiago de Compostela, Spain.
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Suárez-Peñaranda
authors.forename: Ihab
authors.initials: I
authors.lastname: Abdulkader
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Barón-Duarte
authors.forename: Ezequiel
authors.initials: E
authors.lastname: González Patiño
authors.forename: Alejandro
authors.initials: A
authors.lastname: Novo-Domínguez
authors.forename: Juan
authors.initials: J
authors.lastname: Varela-Durán
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018279:Carcinoma, Signet Ring Cell / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology* / Q000556:secondary*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D013274:Stomach Neoplasms / Q000473:pathology; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology* / Q000556:secondary*