Cognitive deficits during status epilepticus and time course of recovery: a case report.
We describe a young woman with progressive cognitive and neurological deficits during a parietal lobe status epilepticus (SE). Ictal FDG-PET showed left parietal lobe hypermetabolism and frontal lobe hypometabolism with concomitant EEG slowing. Cognitive and neurological deficits fully reversed more than 1 year after seizure remission, and were associated with normalization of FDG-PET and EEG. Our findings suggest that ictal hypometabolism and EEG delta activity at a distance from the epileptic focus were seizure-related phenomena, possibly representing inhibition in seizure propagation pathways, which could be responsible for the epileptic encephalopathy.
Van Paesschen
Wim
W
Department of Neurology, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Belgium. Wim.vanpaesschen@z.kuleuven.ac.be
Porke
Kathleen
K
Fannes
Katrien
K
Vandenberghe
Rik
R
Palmini
Andre
A
Van Laere
Koen
K
Dupont
Patrick
P
D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use; D003072:Cognition Disorders / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000503:physiopathology*; D003700:Delta Rhythm / Q000706:statistics & numerical data; D004569:Electroencephalography / Q000706:statistics & numerical data; D005260:Female; D019788:Fluorodeoxyglucose F18; D005500:Follow-Up Studies; D005625:Frontal Lobe / Q000378:metabolism* / Q000503:physiopathology*; D006801:Humans; D009433:Neural Inhibition / Q000502:physiology; D009434:Neural Pathways / Q000378:metabolism / Q000503:physiopathology; D009483:Neuropsychological Tests; D010296:Parietal Lobe / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000503:physiopathology*; D049268:Positron-Emission Tomography / Q000706:statistics & numerical data; D013226:Status Epilepticus / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology*; D013997:Time Factors; D016896:Treatment Outcome
D000927:Anticonvulsants; D019788:Fluorodeoxyglucose F18