title: Aminopyrrolidineamide inhibitors of site-1 protease.
abstract: The discovery and efficacy of a series of potent aminopyrrolidineamide-based inhibitors of sterol regulatory element binding protein site-1 protease is described.
authors.affiliation: Pfizer Global Research and Development-Groton Laboratories, Groton, CT 06340, USA. burce_hay@sbcglobal.net
authors.forename: Bruce A
authors.initials: BA
authors.lastname: Hay
authors.forename: Barbara
authors.initials: B
authors.lastname: Abrams
authors.forename: Allice Y
authors.initials: AY
authors.lastname: Zumbrunn
authors.forename: James J
authors.initials: JJ
authors.lastname: Valentine
authors.forename: Laurie C
authors.initials: LC
authors.lastname: Warren
authors.forename: Stephen F
authors.initials: SF
authors.lastname: Petras
authors.forename: Lorraine D
authors.initials: LD
authors.lastname: Shelly
authors.forename: Angela
authors.initials: A
authors.lastname: Xia
authors.forename: Alison H
authors.initials: AH
authors.lastname: Varghese
authors.forename: Julie L
authors.initials: JL
authors.lastname: Hawkins
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: Van Camp
authors.forename: Michael D
authors.initials: MD
authors.lastname: Robbins
authors.forename: Katherine
authors.initials: K
authors.lastname: Landschulz
authors.forename: H James
authors.initials: HJ
authors.lastname: Harwood
mesh_terms: D021581:Active Transport, Cell Nucleus / Q000187:drug effects; D000818:Animals; D020650:Combinatorial Chemistry Techniques; D005786:Gene Expression Regulation; D006801:Humans; D000960:Hypolipidemic Agents / Q000737:chemistry / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D008297:Male; D051379:Mice; D015394:Molecular Structure; D043484:Proprotein Convertases / Q000037:antagonists & inhibitors*; D011758:Pyrroles / Q000737:chemistry / Q000494:pharmacology*; D012697:Serine Endopeptidases; D051779:Sterol Regulatory Element Binding Proteins / Q000378:metabolism
chemical_list: D000960:Hypolipidemic Agents; D011758:Pyrroles; D051779:Sterol Regulatory Element Binding Proteins; D043484:Proprotein Convertases; D012697:Serine Endopeptidases; C115575:membrane-bound transcription factor peptidase, site 1