title: Doctor T. E. Woodward's legacy: from typhus to typhoid fever.
abstract: Dr. Theodore E. Woodward was one of the early giants of infectious diseases research who set the groundwork for the field. He was the first to evaluate vaccines against typhus, employing volunteers to test the effectiveness of the vaccines. This led to the evaluation of chloramphenicol for the treatment of rickettsial diseases and typhoid fever. Subsequently, he was influential in establishing a unique volunteer unit in Maryland in which a wide range of vaccines were evaluated.
authors.affiliation: Medical Education Administration, Orlando Regional Healthcare System, Orlando, FL 32806, USA. dickh@orhs.org
authors.forename: Richard B
authors.initials: RB
authors.lastname: Hornick
authors.forename: William E
authors.initials: WE
authors.lastname: Woodward
authors.forename: Sheldon E
authors.initials: SE
authors.lastname: Greisman
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002701:Chloramphenicol / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D006381:Helsinki Declaration; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D007258:Informed Consent; D008297:Male; D008396:Maryland; D008887:Military Medicine; D011329:Prisoners; D012281:Rickettsia / Q000187:drug effects / Q000276:immunology; D012282:Rickettsia Infections / Q000188:drug therapy / Q000276:immunology; D012290:Rickettsial Vaccines; D014435:Typhoid Fever / Q000188:drug therapy* / Q000276:immunology; D014436:Typhoid-Paratyphoid Vaccines / Q000266:history*
chemical_list: D000900:Anti-Bacterial Agents; D012290:Rickettsial Vaccines; D014436:Typhoid-Paratyphoid Vaccines; D002701:Chloramphenicol