New Ugi-Smiles-metathesis strategy toward the synthesis of pyrimido azepines.
A new strategy involving Ugi-Smiles coupling followed by ring-closure metathesis is described herein for the preparation of pyrimidine-fused heterocyclic scaffolds. The scope of this sequence is presented in relation with the heteroatom effect observed in the Ugi-Smiles coupling.
El Kaïm
Laurent
L
Laboratoire Chimie et procédés, UMR 7652, Ecole Nationale Supérieure de Techniques Avancées, 32 Boulevard Victor, Paris 75015, France. laurent.elkaim@ensta.fr
Grimaud
Laurence
L
Oble
Julie
J