title: Early stromal invasion in cervical cancer: immunocytochemical changes occurring in infiltrating neoplastic cells.
abstract: Early Stromal Invasion (ESI) in cervical cancer progression should be considered as a separate histological diagnostic category for its morphological characters very different from those of both carcinoma in situ (CIS) and microcarcinoma (MIC). To have some more microscopical details on these differences we performed immunocytochemical investigation addressed to evaluate, in cervical cancer malignancy progression, the evolutionary changes in the expression of some proteins involved in cell differentiation and cell cycle regulation. The results provide data improving the knowledge about ESI and supporting, with objective proofs, the nosological autonomy of ESI, with respect to CIS and MIC.
authors.affiliation: Department of Pathology, University of Verona, Verona, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Tarocco
authors.forename: L
authors.initials: L
authors.lastname: Mariuzzi
authors.forename: R
authors.initials: R
authors.lastname: Bettini
authors.forename: P H
authors.initials: PH
authors.lastname: Bartels
authors.forename: G
authors.initials: G
authors.lastname: Mariuzzi
mesh_terms: D002278:Carcinoma in Situ / Q000175:diagnosis / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D002453:Cell Cycle / Q000502:physiology; D002454:Cell Differentiation / Q000502:physiology; D003937:Diagnosis, Differential; D018450:Disease Progression; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000235:genetics / Q000378:metabolism; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism; D009361:Neoplasm Invasiveness; D018809:Proliferating Cell Nuclear Antigen / Q000235:genetics / Q000378:metabolism; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000235:genetics / Q000378:metabolism; D017154:Stromal Cells / Q000378:metabolism* / Q000473:pathology*; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis / Q000276:immunology / Q000378:metabolism / Q000473:pathology*
chemical_list: C081876:CKAP4 protein, human; D019394:Ki-67 Antigen; D008565:Membrane Proteins; D018809:Proliferating Cell Nuclear Antigen; D019253:Proto-Oncogene Proteins c-bcl-2; D016159:Tumor Suppressor Protein p53; C413374:p27 antigen