Epithelioid fibrous papule - a new variant.
Fibrous papules (FPs) are common benign lesions occurring most frequently on the nose. Multiple variants have been described, including classic, hypercellular, clear cell, pigmented, pleomorphic, inflammatory and granular FPs. We describe a group of FPs with characteristics that do not easily fit into any of the above categories, with diffuse sheets of distinctive epithelioid cells, causing potential diagnostic confusion. Immunoperoxidase stains show that the cells of this 'epithelioid fibrous papule' are reactive for procollagen, and are negative for NKI/C3, unlike previously described clear cell variants.
Kucher
Cynthia
C
Department of Dermatopathology, Yale University School of Medicine, New Haven, CT, USA. cynthiakucher@yahoo.com
McNiff
Jennifer M
JM
D000293:Adolescent; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism; D004847:Epithelial Cells / Q000473:pathology*; D005153:Facial Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D018218:Neoplasms, Fibrous Tissue / Q000378:metabolism / Q000473:pathology*; D011347:Procollagen / Q000378:metabolism; D017444:Skin Diseases, Papulosquamous / Q000378:metabolism / Q000473:pathology*; D012878:Skin Neoplasms / Q000473:pathology*
D014408:Biomarkers, Tumor; D011347:Procollagen