title: Chronic intestinal pseudo-obstruction: manifestations, natural history and management.
abstract: Chronic intestinal pseudo-obstruction (CIPO) is a rare pathological condition characterized by a marked derangement of gut propulsive motility mimicking mechanical obstruction, in the absence of any lesion occluding the gut lumen. This disease is often associated with a disabling and potentially life-threatening complications and is still too often unrecognized even in referral centres. As a result, patients receive neither appropriate care nor recognition of their severe health condition. Medical and surgical therapies are often unsatisfactory and long-term outcome turns out to be poor in the vast majority of cases. This article focuses on the main clinical features, the management and long-term outcome of patients affected by CIPO, with particular emphasis on those aspects which remain a matter of debate.
authors.affiliation: Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy. v.stanghellini@unibo.it
authors.forename: V
authors.initials: V
authors.lastname: Stanghellini
authors.forename: R F
authors.initials: RF
authors.lastname: Cogliandro
authors.forename: R
authors.initials: R
authors.lastname: de Giorgio
authors.forename: G
authors.initials: G
authors.lastname: Barbara
authors.forename: B
authors.initials: B
authors.lastname: Salvioli
authors.forename: R
authors.initials: R
authors.lastname: Corinaldesi
mesh_terms: D002908:Chronic Disease; D013505:Digestive System Surgical Procedures; D016145:Endoscopy, Digestive System; D005765:Gastrointestinal Agents / Q000627:therapeutic use; D005769:Gastrointestinal Motility; D006801:Humans; D007418:Intestinal Pseudo-Obstruction / Q000175:diagnosis* / Q000628:therapy*; D008365:Manometry
chemical_list: D005765:Gastrointestinal Agents