title: Planar polarity and tissue morphogenesis.
abstract: Planar polarity is a global, tissue-level phenomenon that coordinates cell behavior in a two-dimensional plane. The Frizzled/planar cell polarity (PCP) and anterior-posterior (AP) patterning systems for planar polarity operate in a variety of cell types and provide direction to cells with different morphologies and behaviors. These two systems involve different sets of proteins but both use directional cues provided locally by communication between neighboring cells. This review describes our current understanding of the mechanisms that transmit directional signals from cell to cell and compares the strategies for generating global systems of spatial information in stationary and dynamic cell populations.
authors.affiliation: Developmental Biology Program, Sloan-Kettering Institute, New York, NY 10021, USA. zallenj@mskcc.org
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: Zallen
mesh_terms: D000818:Animals; D019521:Body Patterning; D002450:Cell Communication; D016764:Cell Polarity; D004330:Drosophila / Q000235:genetics / Q000378:metabolism; D004848:Epithelium / Q000378:metabolism; D051157:Frizzled Receptors / Q000378:metabolism*; D018507:Gene Expression Regulation, Developmental; D008954:Models, Biological; D009024:Morphogenesis
chemical_list: D051157:Frizzled Receptors