title: Subcutaneous fat necrosis of the newborn with eosinophilic granules.
abstract: Subcutaneous fat necrosis (SFN) of the newborn is a variant of lobular panniculitis characterized by focal areas of fat necrosis and a granulomatous infiltrate composed of lymphocytes, histiocytes and multinucleated giant cells. Lipocytes and histiocytes contain needle-shaped clefts in a radial arrangement. Needle-shaped clefts may also be seen within the cytoplasm of multinucleated giant cells.(1-3) We present an unusual example of SFN showing multinucleated giant cells laced with eosinophilic granules. These eosinophilic granules are believed to be released from surrounding degranulating eosinophils.
authors.affiliation: Department of Dermatology, Brown Medical School, Rhode Island Hospital, RI 02903, USA. ani_tajirian@brown.edu
authors.forename: Ani
authors.initials: A
authors.lastname: Tajirian
authors.forename: Rustin
authors.initials: R
authors.lastname: Ross
authors.forename: Priya
authors.initials: P
authors.lastname: Zeikus
authors.forename: Leslie
authors.initials: L
authors.lastname: Robinson-Bostom
mesh_terms: D003594:Cytoplasmic Granules / Q000473:pathology*; D004802:Eosinophilia / Q000473:pathology*; D005218:Fat Necrosis / Q000473:pathology*; D005260:Female; D015726:Giant Cells / Q000473:pathology; D006801:Humans; D007231:Infant, Newborn; D012075:Remission, Spontaneous; D050151:Subcutaneous Fat / Q000473:pathology*