Expression of ornithine decarboxylase in precancerous and cancerous gastric lesions.
OBJECTIVE
To investigate the expression of ornithine decarboxylase (ODC) in precancerous and cancerous gastric lesions.


METHODS
We studied the expression of ODC in gastric mucosa from patients with chronic superficial gastritis (CSG, n=32), chronic atrophic gastritis [CAG, n=43; 15 with and 28 without intestinal metaplasia (IM)], gastric dysplasia (DYS, n=11) and gastric cancer (GC, n=48) tissues using immunohistochemical staining. All 134 biopsy specimens of gastric mucosa were collected by gastroscopy.


METHODS
The positive rate of ODC expression was 34.4%, 42.9%, 73.3%, 81.8% and 91.7% in cases with CSG, CAG without IM, CAG with IM, DYS and GC, respectively (P<0.01), The positive rate of ODC expression increased in the order of CSG < CAG (without IM) < CAG (with IM) < DYS and finally, GC. In addition, ODC positive immunostaining rate was lower in well-differentiated GC than in poorly-differentiated GC (P<0.05).


CONCLUSIONS
The expression of ODC is positively correlated with the degree of malignity of gastric mucosa and development of gastric lesions. This finding indicates that ODC may be used as a good biomarker in the screening and diagnosis of precancerous lesions.
Miao
Xin-Pu
XP
Department of Gastroenterology, West China Hospital of Sichuan University, 17 Renmin Avenue, Chengdu 610041, Sichuan Province, China. miaoxinpu@163.com
Li
Jian-Sheng
JS
Li
Hui-Yan
HY
Zeng
Shi-Ping
SP
Zhao
Ye
Y
Zeng
Jiang-Zheng
JZ
D000230:Adenocarcinoma / Q000201:enzymology* / Q000235:genetics; D014408:Biomarkers, Tumor / Q000378:metabolism; D005753:Gastric Mucosa / Q000201:enzymology / Q000473:pathology; D005756:Gastritis / Q000201:enzymology / Q000473:pathology; D005757:Gastritis, Atrophic / Q000201:enzymology / Q000473:pathology; D015971:Gene Expression Regulation, Enzymologic; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008679:Metaplasia / Q000201:enzymology / Q000473:pathology; D009955:Ornithine Decarboxylase / Q000235:genetics / Q000378:metabolism*; D011230:Precancerous Conditions / Q000201:enzymology* / Q000235:genetics; D013274:Stomach Neoplasms / Q000201:enzymology* / Q000235:genetics
D014408:Biomarkers, Tumor; D009955:Ornithine Decarboxylase