title: MEDOR, a didactic tool to support interpretation of bioassay data after internal contamination by actinides.
abstract: A didactic software, MEthodes DOsimètriques de REférence (MEDOR), is being developed to provide help in the interpretation of biological data. Its main purpose is to evaluate the pertinence of the application of different models. This paper describes its first version that is focused on inhalation exposure to actinide aerosols. With this tool, sensitivity analysis on different parameters of the ICRP models can be easily done for aerosol deposition, in terms of activity and particle number, actinide biokinetics and doses. The user can analyse different inhalation cases showing either that dose per unit intake cannot be applied if the aerosol contains a low number of particles or that an inhibition of the late pulmonary clearance by particle transport can occur which contributes to a 3-4 fold increase in effective dose as compared with application of default parameters. This underlines the need to estimate systematically the number of deposited particles, as well as to do chest monitoring as long as possible.
authors.affiliation: Service médical du travail, CEA Cadarache, 13108 Saint Paul lez Durance, France.
authors.forename: A
authors.initials: A
authors.lastname: Mièle
authors.forename: N
authors.initials: N
authors.lastname: Blanchin
authors.forename: P
authors.initials: P
authors.lastname: Raynaud
authors.forename: B
authors.initials: B
authors.lastname: Quesne
authors.forename: J M
authors.initials: JM
authors.lastname: Giraud
authors.forename: R
authors.initials: R
authors.lastname: Fottorino
authors.forename: P
authors.initials: P
authors.lastname: Bérard
authors.forename: E
authors.initials: E
authors.lastname: Ansoborlo
authors.forename: D
authors.initials: D
authors.lastname: Franck
authors.forename: E
authors.initials: E
authors.lastname: Blanchardon
authors.forename: C
authors.initials: C
authors.lastname: Challeton-de Vathaire
authors.forename: L
authors.initials: L
authors.lastname: Lebaron-Jacobs
authors.forename: J L
authors.initials: JL
authors.lastname: Poncy
authors.forename: J
authors.initials: J
authors.lastname: Piechowski
authors.forename: P
authors.initials: P
authors.lastname: Fritsch
mesh_terms: D008671:Actinoid Series Elements / Q000032:analysis* / Q000493:pharmacokinetics*; D000465:Algorithms; D001681:Biological Assay / Q000379:methods*; D001822:Body Burden; D006801:Humans; D011829:Radiation Dosage; D011874:Radiometry / Q000379:methods*; D012062:Relative Biological Effectiveness; D012984:Software
chemical_list: D008671:Actinoid Series Elements