[Comparison of ciprofloxacin with biapenem in patients with moderate or severe pneumonia].
We conducted the comparative study to clarify the clinical efficacy and features of ciprofloxacin (CPFX) and biapenem (BIPM) in the treatment of moderate or severe pneumonia. Among 209 patients enrolled, 173 patients (CPFX; 87, BIPM; 86) complying with the protocol were evaluated for safety and 171 (CPFX; 85, BIPM; 86) for efficacy. No significant difference was noted between groups in patient profiles. Both groups were similar in efficacy, as evaluated by the following variables: fever, WBC, CRP, and chest X ray score. The incidence of adverse drug reactions was 16.1% (14/87 patients) in the CPFX group and 16.3% (14/86 patients) in the BIPM group. Phlebitis occasionally occurred in the CPFX group and drug eruption and liver function disorder occasionally in the BIPM group. In conclusion, both CPFX and BIPM were useful in treating moderate or severe pneumonia and no difference was seen between groups in efficacy. Some differences were noted in adverse reactions, however.
Rikimaru
Toru
T
Department of Respiratory Medicine, Saiseikai Futsukaichi Hospital.
Yonemitu
Junko
J
Koga
Takeharu
T
Shimada
Akiko
A
Yokoyama
Toshinobu
T
Kawayama
Tomotaka
T
Kamimura
Tomoko
T
Aizawa
Hisamichi
H
D000368:Aged; D000890:Anti-Infective Agents / Q000009:adverse effects / Q000627:therapeutic use*; D002939:Ciprofloxacin / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D018410:Pneumonia, Bacterial / Q000188:drug therapy*; D013845:Thienamycins / Q000009:adverse effects / Q000627:therapeutic use*
D000890:Anti-Infective Agents; D013845:Thienamycins; D002939:Ciprofloxacin; C065257:biapenem