[Investigating the diagnostic value of MHC-I expression in polymyositis].
OBJECTIVE
To investigate the diagnostic value of MHC-I expression in PM.


METHODS
Analyzing the results of clinical and pathological findings and the immunohistochemical findings of MHC-I expression of 54 cases.


RESULTS
Among the 16 patients with PM, 63 percent patients showed inflammatory infiltration, 94 percent showed MHC-I expression; Among 19 patients with progressive muscular dystrophy, 9 percent patients showed inflammatory infiltration, 11 percent showed MHC-I expression. The other 19 patients showed no inflammatory infiltration and MHC-I expression.


CONCLUSIONS
MHC-I expression as a diagnostic index of PM was appropriate, which had ideal sensitivity, specificity and negative likelihood ratio.
Han
Shun-Chang
SC
Department of Neurology, General Hospital of People's Liberation Army, Beijing 100853, China.
Pu
Chuan-Qiang
CQ
Lang
Sen-Yang
SY
Wu
Wei-Ping
WP
Huang
Xu-Sheng
XS
D000328:Adult; D005260:Female; D015395:Histocompatibility Antigens Class I / Q000096:biosynthesis*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D017285:Polymyositis / Q000175:diagnosis* / Q000378:metabolism* / Q000473:pathology; D011237:Predictive Value of Tests
D015395:Histocompatibility Antigens Class I