von Hippel-Lindau disease: epididymal cystadenoma targeted by metastatic events.
Cases of renal clear cell carcinoma in patients with von Hippel-Lindau disease often exhibit extensive metastasis. Several investigators have shown these tumors to specifically invade central nervous system hemangioblastomas, which are commonly associated with the disease. We report on multiple metastatic events within a single von Hippel-Lindau disease-associated tumor outside the central nervous system, epididymal cystadenoma. The multiplicity of these metastatic events suggests the epididymal cystadenoma as a preferential site of metastasis for von Hippel-Lindau disease-associated renal clear cell carcinoma.
Mehta
Gautam U
GU
Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892-1414, USA.
Shively
Sharon B
SB
Gläsker
Sven
S
Bechert
Charles J
CJ
Zhuang
Zhengping
Z
Raffeld
Mark
M
Lonser
Russell R
RR
Oldfield
Edward H
EH
Vortmeyer
Alexander O
AO
D000328:Adult; D002292:Carcinoma, Renal Cell / Q000473:pathology*; D003537:Cystadenoma / Q000473:pathology; D004822:Epididymis / Q000473:pathology*; D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology*; D008297:Male; D009362:Neoplasm Metastasis; D013736:Testicular Neoplasms / Q000556:secondary*; D006623:von Hippel-Lindau Disease / Q000473:pathology*