title: Trisomy 19 is associated with trisomy 12 and mutated IGHV genes in B-chronic lymphocytic leukaemia.
abstract: The occurrence of trisomy 19 was investigated in 705 cases of B-chronic lymphocytic leukaemia (CLL) by metaphase cytogenetic and/or fluorescence in situ hybridisation analyses. Trisomy 19 was detected in 11 cases (1.6%), all of which also carried a trisomy 12; nine of 10 had mutated IGHV genes. In contrast, B-CLL cases with trisomy 12 lacking trisomy 19 mostly had unmutated IGHV genes. Karyotypes of the present study and the literature identified a strong correlation to trisomy 18 in addition to trisomy 12. Trisomy 19 seems to be a secondary event in B-CLL with trisomy 12, mostly originating from mutated B cells.
authors.affiliation: Department of Haematology, Medical Faculty, University of Duisburg-Essen, Essen, Germany. ludger.sellmann@uk-essen.de
authors.forename: Ludger
authors.initials: L
authors.lastname: Sellmann
authors.forename: Stefan
authors.initials: S
authors.lastname: Gesk
authors.forename: Christoph
authors.initials: C
authors.lastname: Walter
authors.forename: Matthias
authors.initials: M
authors.lastname: Ritgen
authors.forename: Lana
authors.initials: L
authors.lastname: Harder
authors.forename: José I
authors.initials: JI
authors.lastname: Martín-Subero
authors.forename: Roland
authors.initials: R
authors.lastname: Schroers
authors.forename: Dörte
authors.initials: D
authors.lastname: Siemer
authors.forename: Holger
authors.initials: H
authors.lastname: Nückel
authors.forename: Martin J S
authors.initials: MJ
authors.lastname: Dyer
authors.forename: Ulrich
authors.initials: U
authors.lastname: Dührsen
authors.forename: Reiner
authors.initials: R
authors.lastname: Siebert
authors.forename: Jan
authors.initials: J
authors.lastname: Dürig
authors.forename: Ralf
authors.initials: R
authors.lastname: Küppers
mesh_terms: D002881:Chromosomes, Human, Pair 12 / Q000235:genetics; D002888:Chromosomes, Human, Pair 19 / Q000235:genetics; D016000:Cluster Analysis; D005260:Female; D052138:Genes, Neoplasm / Q000235:genetics; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics*; D007135:Immunoglobulin Variable Region / Q000235:genetics*; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009154:Mutation; D014314:Trisomy / Q000235:genetics*
chemical_list: D007143:Immunoglobulin Heavy Chains; D007135:Immunoglobulin Variable Region