Antibodies to HIV-1: aiming at the right target.
HIV-1 evades antibody-mediated neutralization in many cunning ways. The recent structural characterization of a conserved neutralization epitope on the envelope glycoprotein complex (Env) provides clues to the vulnerabilities of the virus. We discuss these observations and explain their relevance for HIV-1 vaccine design.
Eggink
Dirk
D
Laboratory of Experimental Virology, Department of Medical Microbiology, Center of Infection and Immunity Amsterdam (CINIMA), Academic Medical Center of the University of Amsterdam, The Netherlands.
Melchers
Mark
M
Sanders
Rogier W
RW
D016915:AIDS Vaccines / Q000276:immunology*; D000918:Antibody Specificity / Q000276:immunology*; D015195:Drug Design; D000939:Epitopes / Q000737:chemistry / Q000276:immunology; D015699:HIV Envelope Protein gp120 / Q000737:chemistry / Q000276:immunology; D015658:HIV Infections / Q000276:immunology / Q000517:prevention & control*; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D017434:Protein Structure, Tertiary
D016915:AIDS Vaccines; D000939:Epitopes; D015699:HIV Envelope Protein gp120