title: PACAP and PDF signaling in the regulation of mammalian and insect circadian rhythms.
abstract: Endogenous circadian clocks are inherent to all living organisms. They are needed to guarantee successful life since they regulate very important biological processes such as behavior and reproduction. Secretin-like G-protein coupled receptors are very important factors in the signal transduction pathways of circadian clocks. In this review, we will focus on the role of two secretin-like signaling pathways that play an important role in the regulation of the mammalian and the insect clock, respectively: the pituitary adenylate cyclase-activating polypeptide (PACAP) and pigment dispersing factor (PDF) signaling pathways. Both pathways are most likely related although their function in the biological clock differs.
authors.affiliation: Animal Physiology and Neurobiology, Katholieke Universiteit Leuven, Naamsestraat 59, 3000 Leuven, Belgium.
authors.forename: Inge
authors.initials: I
authors.lastname: Mertens
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Husson
authors.forename: Tom
authors.initials: T
authors.lastname: Janssen
authors.forename: Marleen
authors.initials: M
authors.lastname: Lindemans
authors.forename: Liliane
authors.initials: L
authors.lastname: Schoofs
mesh_terms: D000818:Animals; D002940:Circadian Rhythm / Q000235:genetics / Q000502:physiology*; D005786:Gene Expression Regulation; D007313:Insecta; D007447:Invertebrate Hormones / Q000235:genetics / Q000502:physiology*; D008954:Models, Biological; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide / Q000235:genetics / Q000502:physiology*; D011498:Protein Precursors / Q000235:genetics / Q000502:physiology*; D051236:Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide / Q000235:genetics / Q000502:physiology; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology*
chemical_list: D007447:Invertebrate Hormones; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide; D011498:Protein Precursors; D051236:Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide; C079085:pigment dispersing hormone precursor