title: Aspirin-resistant platelet aggregation in a cohort of patients with coronary heart disease.
abstract: Aspirin resistance could be defined as thrombotic and embolic cardiovascular events despite regular aspirin therapy. The study aimed to determine the profile and prevalence of aspirin resistance in coronary artery disease patients. We evaluated the prevalence of aspirin resistance in a cohort of 505 patients with the diagnosis of coronary artery disease taking 80-300 mg regular aspirin daily. Platelet functions were analyzed by the Platelet Function Analyzer (PFA)-100 with collagen and epinephrine cartridges and collagen and ADP cartridges. A closure time of 186 s or less with the collagen and epinephrine cartridge was defined as aspirin resistance. Of the patients, 118 (23.4%) were aspirin resistant by the PFA-100. Aspirin-resistant patients were more likely to be older than aspirin-sensitive patients (P = 0.024). No statistically significant differences between the aspirin-resistant and aspirin-sensitive individuals were present in gender, major risk factors of coronary artery disease, number and localization of involved coronary vessels, serum lipid levels, and blood counts. According to the high prevalence of coronary heart disease, many people are affected by aspirin resistance, which may play a role in adverse cardiovascular events. Monitoring of platelet function in patients with coronary heart disease may support the optimization of antiplatelet therapy with additional and/or alternative agents.
authors.affiliation: Department of Cardiology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey. bpamukcu@gmail.com
authors.forename: Burak
authors.initials: B
authors.lastname: Pamukcu
authors.forename: Huseyin
authors.initials: H
authors.lastname: Oflaz
authors.forename: Imran
authors.initials: I
authors.lastname: Onur
authors.forename: Aytac
authors.initials: A
authors.lastname: Oncul
authors.forename: Berrin
authors.initials: B
authors.lastname: Umman
authors.forename: Nevres
authors.initials: N
authors.lastname: Koylan
authors.forename: Zehra
authors.initials: Z
authors.lastname: Bugra
authors.forename: Mehmet
authors.initials: M
authors.lastname: Meric
authors.forename: Yilmaz
authors.initials: Y
authors.lastname: Nisanci
mesh_terms: D000368:Aged; D001241:Aspirin / Q000008:administration & dosage / Q000009:adverse effects*; D015331:Cohort Studies; D003324:Coronary Artery Disease / Q000097:blood* / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology; D004351:Drug Resistance; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage / Q000009:adverse effects*; D010979:Platelet Function Tests; D015995:Prevalence; D013927:Thrombosis / Q000097:blood* / Q000139:chemically induced / Q000188:drug therapy / Q000453:epidemiology
chemical_list: D010975:Platelet Aggregation Inhibitors; D001241:Aspirin