In vitro activity of azithromycin: A long-acting azalide.
The in vitro activity of azithromycin, an orally active azalide, was compared with that of erythromycin and oral beta-lactams against 893 clinical isolates of staphylococci, streptococci, enterococci, Haemophilus influenzae and Salmonella typhi. MIC90 of azithromycin for streptococci was 0.12 mg/L, 0.5 mg/L for H. influenzae, 8.0 mg/L for Salmonella typhi and methicillin-susceptible Staphylococcus aureus. Like erythromycin and the beta-lactams tested, it had little or no activity against enterococci, methicillin-resistant S. aureus and coagulase negative staphylococci.
Qadri
S H
SH
Department of Pathology and Laboratory Medicine, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
Ueno
Y
Y
Tullo
D
D
Postle
G
G