title: Comparison of Crinone 8% intravaginal gel and intramuscular progesterone supplementation for in vitro fertilization/embryo transfer in women under age 40: interim analysis of a prospective randomized trial.
abstract: This study was performed to compare the efficacy of Crinone 8% intravaginal gel and intramuscular progesterone (IMP) supplementation for luteal phase support in women under age 40 undergoing IVF-ET. Results of the interim analysis of this rigorously designed prospective randomized controlled study are presented. Pregnancy rates, implantation rates, and early spontaneous abortion rates were similar for patients receiving Crinone or IMP, whereas fewer side effects and greater overall satisfaction were reported by women receiving Crinone.
authors.affiliation: Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA. eyanushpolsky@partners.org
authors.forename: Elena
authors.initials: E
authors.lastname: Yanushpolsky
authors.forename: Shelley
authors.initials: S
authors.lastname: Hurwitz
authors.forename: Louise
authors.initials: L
authors.lastname: Greenberg
authors.forename: Catherine
authors.initials: C
authors.lastname: Racowsky
authors.forename: Mark D
authors.initials: MD
authors.lastname: Hornstein
mesh_terms: D000328:Adult; D000367:Age Factors; D010064:Embryo Implantation / Q000187:drug effects; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D006801:Humans; D007273:Injections, Intramuscular; D008423:Maternal Age; D011247:Pregnancy; D018873:Pregnancy Rate; D011374:Progesterone / Q000008:administration & dosage* / Q000031:analogs & derivatives*; D013223:Statistics as Topic / Q000379:methods; D016896:Treatment Outcome; D014622:Vaginal Creams, Foams, and Jellies / Q000737:chemistry
chemical_list: C400424:Crinone; D014622:Vaginal Creams, Foams, and Jellies; D011374:Progesterone