[The intervention of tetrandrine in the acute renal injury induced by streptomycin sulfate in puinea pigs].
The article investigated the intervention and the protective mechanism of tetrandrine (Tet) on acute renal injury induced by streptomycin (SM). The experimental healthy albinoa pigs of each sex with both ears' threshold of auditory brainstem response (ABR) < or = 5dB were divided into 4 groups by randomized blocks, including group 1 (control), group 2 (tetradrine), group 3 (SM) and group 4(Tet+SM). After 10 days, the urinary specimen were set apart for the determination of NAG activity, renal specimen were reserved for observing the renal histology. The renal histology shows that the injury of group 3 is most grievous, the injury of group 4 is lighter than that of group 3, in addition, the apoptosis is obviously less than that of group 3. The activity of urine of NAG in group 4 is lower than that of group 3 (P < 0.01). The results suggested that tetrandrine has obvious antagonism action upon renal toxic effect induced by SM. Therefore, the tetrandrine has potential application prospect in protection against pharmaceutical organ injury.
An
Yu Xiang
YX
Shenyang Normal University, Shenyang 110034.
Zhao
Hui Ping
HP
Xu
Xin
X
D000818:Animals; D044182:Benzylisoquinolines / Q000494:pharmacology / Q000627:therapeutic use*; D006168:Guinea Pigs; D007668:Kidney / Q000187:drug effects* / Q000473:pathology; D015882:Retinal Necrosis Syndrome, Acute / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D013307:Streptomycin / Q000633:toxicity*
D044182:Benzylisoquinolines; C009438:tetrandrine; D013307:Streptomycin