Divergence of hypertrophic growth and fetal gene profile: the influence of beta-blockers.
While the expression patterns of cardiac hypertrophy-related genes have been well documented and widely used as markers for hypertrophy, recent research has revealed uncoupling of hypertrophy-related gene profiles and hypertrophic growth. The role of beta-adrenergic signalling in the development of hypertrophy is incompletely understood. The finding of an upregulated expression of hypertrophy-related genes but a suppressed hypertrophy following beta-blockade reveals previously unrecognized sympatho-adrenergic mechanisms of hypertrophic growth.
Du
X-J
XJ
Experimental Cardiology Laboratory, Baker Heart Research Institute, Melbourne, Victoria, Australia. xiaojun.du@baker.edu.au
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000818:Animals; D006332:Cardiomegaly / Q000235:genetics*; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation / Q000187:drug effects; D008790:Metoprolol / Q000494:pharmacology; D011412:Propanolamines / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology
D000319:Adrenergic beta-Antagonists; D011412:Propanolamines; C026777:ICI 118551; D011433:Propranolol; D008790:Metoprolol