[Expression of apoptosis inhibitor gene Livin in bladder transitional cell carcinoma and clinical implication thereof].
OBJECTIVE
To study the expression of Livin, an apoptosis inhibitor gene, in bladder transitional cell carcinoma (TCC), and to investigate its clinical and pathological implications.


METHODS
Reverse Transcription-Polymerase Chain Reaction (RT-PCR) was used to detect the expression of Livin in the tissues of TCC, 21 among them being recurrent carcinoma, obtained during operation from 60 cases, 48 males and 12 females, aged 58.6 (34 approximately 85), and 10 samples of tissues far from the TCC from the 60 cases.


RESULTS
The overall positive rate of Livin in the 60 cases of TCC was 28.3% (17/60), and was 0 in the 10 cases of tissues far from the TCC. The Livin positivity was not correlated with tumor stage and grade (both P > 0.05). The positive rate of the recurrent bladder carcinoma was 38.1% (8/21), higher than that of the primary bladder carcinoma (23.1%, 9/39), however, not significantly (P > 0.05).


CONCLUSIONS
Livin may play an essential role in bladder carcinogenesis and serve as a marker for prognosis of bladder carcinoma.
Song
Tao
T
Department of Urology, General Hospital of PLA, Beijing 100853, China. songtao6669@163.com
Hong
Bao-fa
BF
Gao
Jiang-ping
JP
Cai
Wei
W
Wang
Chun-yang
CY
D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics* / Q000502:physiology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002295:Carcinoma, Transitional Cell / Q000235:genetics / Q000473:pathology*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins / Q000235:genetics* / Q000502:physiology; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000235:genetics* / Q000502:physiology; D009367:Neoplasm Staging; D011379:Prognosis; D020133:Reverse Transcriptase Polymerase Chain Reaction; D001749:Urinary Bladder Neoplasms / Q000235:genetics / Q000473:pathology*
D048868:Adaptor Proteins, Signal Transducing; C419866:BIRC7 protein, human; D051034:Inhibitor of Apoptosis Proteins; D009363:Neoplasm Proteins