title: Quantifying fixation in patients with Stargardt disease.
abstract: Fixational eye movements in 60 eyes of 30 patients with ABCA4-associated Stargardt disease were recorded by a Scanning Laser Ophthalmoscope (SLO). The results were quantified by two new fixation quality measures expressing the eccentricity of the preferred retinal locus (PRL) non-parametrically, and fixation stability by a dynamic index. 46 eyes (77%) fixated eccentrically; in 32 eyes (70% of the eccentrically fixating eyes) the PRL was located above the central retinal lesion. PRL eccentricity correlated positively with logMAR visual acuity (r=.72; p<.0001) and negatively with fixation stability (r=-.58; p<.0001). Multiple PRL were found only in three eyes.
authors.affiliation: University Eye Hospital, Schleichstr. 12, 72076 Tübingen, Germany. jens.reinhard@med.uni-tuebingen.de
authors.forename: Jens
authors.initials: J
authors.lastname: Reinhard
authors.forename: André
authors.initials: A
authors.lastname: Messias
authors.forename: Klaus
authors.initials: K
authors.lastname: Dietz
authors.forename: Manfred
authors.initials: M
authors.lastname: Mackeben
authors.forename: Raimund
authors.initials: R
authors.lastname: Lakmann
authors.forename: Hendrik P N
authors.initials: HP
authors.lastname: Scholl
authors.forename: Eckart
authors.initials: E
authors.lastname: Apfelstedt-Sylla
authors.forename: Bernhard H F
authors.initials: BH
authors.lastname: Weber
authors.forename: Mathias W
authors.initials: MW
authors.lastname: Seeliger
authors.forename: Eberhart
authors.initials: E
authors.lastname: Zrenner
authors.forename: Susanne
authors.initials: S
authors.lastname: Trauzettel-Klosinski
mesh_terms: D018528:ATP-Binding Cassette Transporters / Q000235:genetics; D000293:Adolescent; D000328:Adult; D005133:Eye Movements; D005260:Female; D005403:Fixation, Ocular; D005584:Fovea Centralis / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D009887:Ophthalmoscopy; D009898:Optic Disk / Q000473:pathology; D012162:Retinal Degeneration / Q000235:genetics / Q000473:pathology / Q000503:physiopathology*; D014792:Visual Acuity
chemical_list: C056475:ABCA4 protein, human; D018528:ATP-Binding Cassette Transporters