title: Hypoadiponectinemia in type 2 diabetes mellitus in men is associated with sympathetic overactivity as evaluated by cardiac 123I-metaiodobenzylguanidine scintigraphy.
abstract: Hypoadiponectinemia is associated with insulin resistance. However, there is very limited information about the relationship between plasma adiponectin and cardiac autonomic nervous function. We tested the hypothesis that hypoadiponectinemia is associated with cardiac sympathetic overactivity in patients with type 2 diabetes mellitus. Thirty-three male type 2 diabetic patients not on insulin treatment were classified into a hypoadiponectinemia group (plasma adiponectin concentration, <4.0 microg/mL; age, 58.6 +/- 8.6 years [mean +/- SD]; n = 14) and an age-matched normoadiponectinemia group (serum adiponectin concentration, >/=4.0 microg/mL; age, 58.2 +/- 8.1 years; n = 19). In each patient, baroreflex sensitivity, heart rate variability, plasma norepinephrine concentration, and cardiac (123)I-metaiodobenzylguanidine (MIBG) scintigraphic findings were assessed. Compared with the normoadiponectinemia group, the hypoadiponectinemia group had a higher body mass index (P < .01), higher plasma concentrations of glucose and insulin (P < .05 and P < .01, respectively), higher homeostasis model assessment of insulin resistance (HOMA-IR) values (P < .005), higher plasma triglyceride levels (P < .05), and lower plasma high-density lipoprotein cholesterol levels (P < .05). In the hypoadiponectinemia group, the autonomic function measurements included a lower baroreflex sensitivity (P< .05) and a lower delayed myocardial uptake of (123)I-MIBG (P < .01) with a higher washout rate (P < .05). Multiple regression analysis revealed that the plasma adiponectin level was independently associated with HOMA-IR (F = 9.916) and the percent washout rate of (123)I-MIBG (F = 5.985). Our results suggest that in middle-aged men with type 2 diabetes mellitus, hypoadiponectinemia is associated with cardiac sympathetic overactivity as determined by (123)I-MIBG scintigraphy.
authors.affiliation: Department of Internal Medicine 1, Faculty of Medicine, Oita University, Oita 879-5593, Japan. takanao@med.oita-u.ac.jp
authors.forename: Naohiko
authors.initials: N
authors.lastname: Takahashi
authors.forename: Futoshi
authors.initials: F
authors.lastname: Anan
authors.forename: Mikiko
authors.initials: M
authors.lastname: Nakagawa
authors.forename: Kunio
authors.initials: K
authors.lastname: Yufu
authors.forename: Tetsuji
authors.initials: T
authors.lastname: Shinohara
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Tsubone
authors.forename: Koro
authors.initials: K
authors.lastname: Goto
authors.forename: Takayuki
authors.initials: T
authors.lastname: Masaki
authors.forename: Isao
authors.initials: I
authors.lastname: Katsuragi
authors.forename: Katsuhiro
authors.initials: K
authors.lastname: Tanaka
authors.forename: Testsuya
authors.initials: T
authors.lastname: Kakuma
authors.forename: Masahide
authors.initials: M
authors.lastname: Hara
authors.forename: Tetsunori
authors.initials: T
authors.lastname: Saikawa
authors.forename: Hironobu
authors.initials: H
authors.lastname: Yoshimatsu
mesh_terms: D019797:3-Iodobenzylguanidine; D052242:Adiponectin / Q000097:blood*; D000368:Aged; D017704:Baroreflex; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000503:physiopathology*; D006321:Heart / Q000000981:diagnostic imaging* / Q000294:innervation; D006339:Heart Rate; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D013564:Sympathetic Nervous System / Q000503:physiopathology*
chemical_list: D052242:Adiponectin; D019275:Radiopharmaceuticals; D019797:3-Iodobenzylguanidine