[Effect of saikosaponin alpha on experimental epilepsy in rats].
OBJECTIVE
To investigate the effect of saikosaponin alpha (SSalpha) on experimental epilepsy in rats.


METHODS
Acute epileptic seizure was induced by pentylenetetrazole (PTZ) in rats, and the seizure incubation period and the number of rats with tetanic convulsion were recorded to study the antiepileptic effect of SSalpha.


RESULTS
After treatment with SSalpha, the incubation period of PTZ-induced seizure was significantly prolonged (P<0.01), and the rate of tetanic convulsion was significantly reduced (P<0.05).


CONCLUSIONS
SSalpha can inhibit epileptic seizure induced by PTZ.
Li
Chang-zheng
CZ
Department of Traditional Chinese Medicine, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. lcztcm@126.com
Xie
Wei
W
Bao
Yong
Y
Zhou
Ye
Y
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D000927:Anticonvulsants / Q000494:pharmacology; D004827:Epilepsy / Q000139:chemically induced / Q000517:prevention & control*; D005260:Female; D008297:Male; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D010433:Pentylenetetrazole; D051381:Rats; D017207:Rats, Sprague-Dawley; D012503:Saponins / Q000494:pharmacology*; D013997:Time Factors
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000927:Anticonvulsants; D012503:Saponins; D009828:Oleanolic Acid; C025759:saikosaponin D; D010433:Pentylenetetrazole