title: Treatment of sudden sensorineural hearing loss: II. A Meta-analysis.
abstract: OBJECTIVE
  To pool and meta-analyze the results of all randomized controlled trials (RCTs) on treatment of sudden sensorineural hearing loss (SSHL).
  
  
  METHODS
  A MEDLINE search and hand search were conducted to identify RCTs published between January 1966 and February 2006 in the English language on the treatment of SSHL. Search terms included hearing loss, sensorineural (MeSH term), sensorineural hearing loss (text words), and sudden deafness (text words).
  
  
  METHODS
  Prospective RCTs on the treatment of patients diagnosed as having sudden sensorineural hearing loss.
  
  
  METHODS
  A meta-analysis using the random effects model was conducted when data existed for 2 or more studies. Odds ratios (ORs), 95% confidence intervals (CIs), and tests for heterogeneity were reported.
  
  
  RESULTS
  Twenty RCTs were identified, of which 5 met inclusion criteria for meta-analysis. Pooling of data from 2 RCTs that compared steroids with placebo showed no difference between treatment groups (OR, 2.47; 95% CI, 0.89-6.84; P=.08). No difference existed between patients treated with antiviral plus steroid therapy vs placebo plus steroid therapy (OR, 0.92; 95% CI, 0.29-2.92: P=.88). Finally, there was no difference between subjects treated with steroids vs subjects treated with any other active treatment (OR, 1.27; 95% CI, 0.64-2.55; P=.50).
  
  
  CONCLUSIONS
  Despite the traditional practice in North America of treating of SSHL with systemic steroids, a meta-analysis revealed no evidence of benefit of steroids over placebo. There was also no difference in the addition of antiviral therapy to systemic steroids, nor was there difference between systemic steroids and other active treatment.
authors.affiliation: Department of Otolaryngology, University of Ottawa, Ottawa, Ontario, Canada.
authors.forename: Anne Elizabeth
authors.initials: AE
authors.lastname: Conlin
authors.forename: Lorne S
authors.initials: LS
authors.lastname: Parnes
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use; D001299:Audiometry; D004338:Drug Combinations; D006319:Hearing Loss, Sensorineural / Q000628:therapy*; D003639:Hearing Loss, Sudden / Q000628:therapy*; D006438:Hemodilution; D006801:Humans; D008274:Magnesium / Q000627:therapeutic use; D010919:Placebos; D011446:Prospective Studies; D016032:Randomized Controlled Trials as Topic; D015203:Reproducibility of Results; D013256:Steroids / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D000998:Antiviral Agents; D004338:Drug Combinations; D010919:Placebos; D013256:Steroids; D008274:Magnesium