title: Computer-aided diagnosis of hepatic fibrosis: preliminary evaluation of MRI texture analysis using the finite difference method and an artificial neural network.
abstract: OBJECTIVE
  The purpose of our study was to preliminarily evaluate the usefulness of a computer algorithm analysis using the finite difference method and an artificial neural network to diagnose hepatic fibrosis with MR images.
  
  
  METHODS
  Liver parenchymal textures on the MR images of 52 patients who underwent partial hepatectomy were processed by the computer algorithm and reviewed by two radiologists. The texture features using the finite difference method were processed by an artificial neural network program containing a three-layer learning algorithm of the back propagation, composed of a seven-unit input layer, a six-unit hidden layer, and a one-unit output layer. The radiologists assigned confidence levels for the presence of hepatic fibrosis. Degrees of hepatic fibrosis were determined semiquantitatively by a pathologist. Algorithm outputs and radiologists' interpretations were correlated with degrees of fibrosis using Spearman's rank correlation analysis, and diagnostic performances were evaluated using receiver operating characteristic curve analysis.
  
  
  RESULTS
  By the computer algorithm, the A(z) (area under the curve) value was greater for gadolinium-enhanced equilibrium phase images (A(z) = 0.801) than for T1-weighted (A(z) = 0.597) or T2-weighted (A(z) = 0.525) images (p < 0.05), and the outputs of equilibrium phase images showed a moderate correlation (r = 0.502, p = 0.001) with the pathologic grades. By the radiologists' interpretations, the A(z) value for all images combined (A(z) = 0.715) was greater than that of portal venous phase images (A(z) = 0.503) (p < 0.05), and the confidence levels of all images combined were moderately correlated (r = 0.473, p = 0.002) with pathologic grades.
  
  
  CONCLUSIONS
  Computer algorithm analysis of equilibrium phase images was found to reflect the degree of fibrosis most accurately. MR image texture analysis performed using the computer algorithm was found to have a potential usefulness for the diagnosis of hepatic fibrosis.
authors.affiliation: Department of Radiology, Gifu University School of Medicine, 1-1 Yanagido, Gifu 501-1194, Japan. hkato@gifu-u.ac.jp
authors.forename: Hiroki
authors.initials: H
authors.lastname: Kato
authors.forename: Masayuki
authors.initials: M
authors.lastname: Kanematsu
authors.forename: Xuejun
authors.initials: X
authors.lastname: Zhang
authors.forename: Masanao
authors.initials: M
authors.lastname: Saio
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kondo
authors.forename: Satoshi
authors.initials: S
authors.lastname: Goshima
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Fujita
mesh_terms: D000368:Aged; D000465:Algorithms; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008103:Liver Cirrhosis / Q000175:diagnosis*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D016571:Neural Networks, Computer; D009716:Numerical Analysis, Computer-Assisted; D010363:Pattern Recognition, Automated / Q000379:methods*; D010865:Pilot Projects; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity