Models of active transport of neurotransmitters in synaptic vesicles.
Models of the active transport of neurotransmitters in synaptic vesicles were constructed. The models were used to determine the resting potential at membranes of synaptic vesicles: 40mV (monoamines and acetylcholine) and -40mV (glutamate). The potential at the membrane of a synaptic vesicle was almost absent for the transport of GABA and glycine. The neurotransmitter concentration of a cell was 0.1-18mM at the concentration of neurotransmitters in a vesicle equal to 0.5M. This result is in qualitative agreement with the relevant experimental data.
Melkikh
Alexey V
AV
Molecular Physics Chair, Ural State Technical University, 19 Mira Street, 620002 Yekaterinburg, Russia. mav@dpt.ustu.ru
Seleznev
Vladimir D
VD
D000818:Animals; D001693:Biological Transport, Active / Q000502:physiology*; D006801:Humans; D008564:Membrane Potentials; D008959:Models, Neurological; D018377:Neurotransmitter Agents / Q000378:metabolism*; D009435:Synaptic Transmission / Q000502:physiology; D013572:Synaptic Vesicles / Q000378:metabolism*
D018377:Neurotransmitter Agents