title: Tissue synchronization imaging of myocardial dyssynchronicity of the left ventricle in patients with coronary artery disease.
abstract: OBJECTIVE
  The purpose of this study was to evaluate regional myocardial dyssynchronicity and velocity of the left ventricle in patients with coronary artery disease.
  
  
  METHODS
  Tissue synchronization imaging analysis of the time to peak velocity (Tp) and peak velocity (Vp) of left ventricular longitudinal myocardial segments was performed for 60 patients with coronary artery disease and 40 healthy subjects.
  
  
  RESULTS
  Tissue synchronization imaging revealed synchronous myocardia in the control group and disturbed myocardial synchrony in patients, with greater dyssynchrony than in the control group (P < .005). Compared with the control group, patients showed a higher Tp of the left ventricular anterior wall and interventricular septum (P < .001). The apex-to-base gradient of tissue velocity was absent in patients. The mean Vp of all segments except the apical segment of the interventricular septum in patients was decreased significantly (P < .05).
  
  
  CONCLUSIONS
  Tissue synchronization imaging is a novel and noninvasive technique for quantitatively assessing regional myocardial Tp and Vp and can directly and quickly determine ischemia or infarction in myocardial segments.
authors.affiliation: Department of Ultrasound, Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Rd, Nangang District, 150086 Harbin, China. jwtian2004@yahoo.com.cn
authors.forename: Jia-Wei
authors.initials: JW
authors.lastname: Tian
authors.forename: Guo-Qing
authors.initials: GQ
authors.lastname: Du
authors.forename: Min
authors.initials: M
authors.lastname: Ren
authors.forename: Li-Tao
authors.initials: LT
authors.lastname: Sun
authors.forename: Xiao-Ping
authors.initials: XP
authors.lastname: Leng
authors.forename: Yan-Xin
authors.initials: YX
authors.lastname: Su
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D003327:Coronary Disease / Q000000981:diagnostic imaging*; D004452:Echocardiography; D018618:Echocardiography, Doppler, Color; D004562:Electrocardiography; D005260:Female; D006346:Heart Septum / Q000503:physiopathology; D006352:Heart Ventricles / Q000503:physiopathology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000502:physiology; D009203:Myocardial Infarction / Q000175:diagnosis / Q000000981:diagnostic imaging; D017202:Myocardial Ischemia / Q000175:diagnosis / Q000000981:diagnostic imaging; D013997:Time Factors; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging*