title: Synthesis and biological action of novel 4-position-modified derivatives of D-myo-inositol 1,4,5-trisphosphate.
abstract: The design of a range of 4-position-modified D-myo-inositol 1,4,5-trisphosphate derivatives is described. The enantioselective synthesis of these compounds is reported, along with initial biological analysis, which indicates that these compounds do not act as D-myo-inositol 1,4,5-trisphosphate receptor agonists or antagonists.
authors.affiliation: EaStCHEM and School of Chemistry, Centre for Biomolecular Sciences, University of St Andrews, North Haugh, St Andrews, Fife, United Kingdom.
authors.forename: Davide
authors.initials: D
authors.lastname: Bello
authors.forename: Tashfeen
authors.initials: T
authors.lastname: Aslam
authors.forename: Geert
authors.initials: G
authors.lastname: Bultynck
authors.forename: Alexandra M Z
authors.initials: AM
authors.lastname: Slawin
authors.forename: H Llewelyn
authors.initials: HL
authors.lastname: Roderick
authors.forename: Martin D
authors.initials: MD
authors.lastname: Bootman
authors.forename: Stuart J
authors.initials: SJ
authors.lastname: Conway
mesh_terms: D002460:Cell Line; D018360:Crystallography, X-Ray; D015544:Inositol 1,4,5-Trisphosphate / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D015544:Inositol 1,4,5-Trisphosphate