Passive smoking, Cyp1A1 gene polymorphism and dysmenorrhea.
OBJECTIVE
This study investigated whether the association between passive smoking exposure and dysmenorrhea is modified by two susceptibility genes, CYP1A1MspI and CYP1A1HincII.


METHODS
This report includes 1645 (1124 no dysmenorrhea, 521 dysmenorrhea) nonsmoking and nondrinking newly wed female workers at Anqing, China between June 1997 and June 2000. Multiple logistic regression models were used to estimate the associations of passive smoking exposure and genetic susceptibility with dysmenorrhea, adjusting for perceived stress.


RESULTS
When stratified by women genotype, the adjusted OR of dysmenorrhea was 1.6 (95%CI=1.3-2.1) for passive smoking group with Ile/Ile462 genotype, and 1.5 (95%CI=1.1-2.1) with C/C6235 genotype, compared to nonpassive smoking group, respectively. The data further showed that there was a significant combined effect between passive smoking and the CYP1A1 MspI C/C6235 and HincII Ile/Ile462 genotype (OR=2.6, 95%CI=1.3-5.2).


CONCLUSIONS
CYP1A1 MspI and HincII genotypes modified the association between passive smoking and dysmenorrhea.
Liu
Hong
H
Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China.
Yang
Fan
F
Li
Zhiping
Z
Chen
Changzhong
C
Fang
Zhian
Z
Wang
Lihua
L
Hu
Yonghua
Y
Chen
Dafang
D
D000328:Adult; D002681:China; D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics*; D004412:Dysmenorrhea / Q000209:etiology* / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D016015:Logistic Models; D017533:Marital Status; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D011446:Prospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D013783:Textile Industry; D013997:Time Factors; D014028:Tobacco Smoke Pollution / Q000009:adverse effects*; D016387:Women's Health
D014028:Tobacco Smoke Pollution; D019363:Cytochrome P-450 CYP1A1