Inhibition of lysine biosynthesis: an evolving antibiotic strategy.
Bacterial biosynthesis of lysine has come under increased scrutiny as a target for novel antibacterial agents as it provides lysine for protein synthesis and both lysine and meso-diaminopimelate for construction of the bacterial peptidoglycan cell wall. In this Highlight article we review recent advances in the validation of antibiotic targets, studies of the enzymes of the lysine biosynthetic pathway and development of inhibitors of these enzymes.
Hutton
Craig A
CA
School of Chemistry, The University of Melbourne, Parkville, VIC 3010, Australia. chutton@unimelb.edu.au
Perugini
Matthew A
MA
Gerrard
Juliet A
JA
D000591:Amino Acid Isomerases / Q000378:metabolism; D000594:Amino Acid Oxidoreductases / Q000378:metabolism; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D053898:Biosynthetic Pathways / Q000187:drug effects; D008239:Lysine / Q000096:biosynthesis* / Q000737:chemistry; D008954:Models, Biological; D015394:Molecular Structure
D000900:Anti-Bacterial Agents; D000594:Amino Acid Oxidoreductases; D000591:Amino Acid Isomerases; D008239:Lysine