Reversible phosphorylation and regulation of mammalian oocyte meiotic chromatin remodeling and segregation.
The mammalian oocyte is notorious for high rates of chromosomal abnormalities. This results in subsequent embryonic aneuploidy, resulting in infertility and congenital defects. Therefore, understanding regulatory mechanisms involved in chromatin remodeling and chromosome segregation during oocyte meiotic maturation is imperative to fully understand the complex process and establish potential therapies. This review will focus on major events occurring during oocyte meiosis, critical to ensure proper cellular ploidy. Mechanistic and cellular events such as chromosome condensation, meiotic spindle formation, as well as cohesion of homologues and sister chromatids will be discussed, focusing on the role of reversible phosphorylation in control of these processes.
Swain
J E
JE
Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109-0617, USA.
Smith
G D
GD
D000818:Animals; D042002:Chromatin Assembly and Disassembly; D020090:Chromosome Segregation; D005260:Female; D006801:Humans; D008322:Mammals / Q000502:physiology*; D008540:Meiosis / Q000502:physiology*; D009865:Oocytes / Q000378:metabolism* / Q000648:ultrastructure; D010766:Phosphorylation