Cortical reorganization in patients with cervical spondylotic myelopathy.
OBJECTIVE
Recent investigations have demonstrated that the cerebral cortex can reorganize as a result of spinal cord injury and may play a role in preserving neurological function. Reorganization of cortical representational maps in patients with cervical spondylotic myelopathy (CSM) has not been previously described. The authors sought to determine the feasibility of using functional magnetic resonance (fMR) imaging in patients with CSM to investigate changes in the cortical representation of the wrist and ankle before and after surgical intervention.


METHODS
Four patients with clinical and imaging evidence of CSM were prospectively enrolled in this study. The patients underwent preoperative neurological examination, functional assessment, cervical imaging, and brain fMR imaging. The fMR imaging activation task undertaken was either wrist extension or ankle dorsiflexion, depending on whether the patient's primary impairment was hand dysfunction or gait difficulty. The cohort then underwent further evaluations at 6 weeks and 3 and 6 months postoperatively. In addition, five healthy volunteers underwent fMR imaging at two different time points and served as controls. In the healthy volunteers fMR imaging demonstrated areas of focal cortical activation limited to the contralateral primary motor area for the assigned motor tasks; the activation patterns were stable throughout repeated imaging. In comparison, in patients with CSM fMR imaging demonstrated expansion of the cortical representation of the affected extremity. Surgical decompression resulted in improvements in neurological function and reorganization of the representational map.


CONCLUSIONS
The findings of this preliminary study demonstrate the potential of fMR imaging to assess changes in cortical representation before and after surgical intervention in patients with CSM. A future study involving a larger cohort of patients as well as the stratification of patients with CSM, based on the aforementioned factors that influence cortical adaptation, will allow a more detailed quantitative analysis.
Holly
Langston T
LT
Division of Neurosurgery, David Geffen School of Medicine, University of California at Los Angeles, California 90095, USA. lholly@mednet.ucla.edu
Dong
Yun
Y
Albistegui-DuBois
Richard
R
Marehbian
Jonathan
J
Dobkin
Bruce
B
D000328:Adult; D000368:Aged; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000473:pathology / Q000503:physiopathology*; D002574:Cervical Vertebrae; D015331:Cohort Studies; D019299:Decompression, Surgical; D005240:Feasibility Studies; D005260:Female; D005528:Foot / Q000503:physiopathology; D005684:Gait; D006225:Hand / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009069:Movement Disorders / Q000209:etiology / Q000503:physiopathology; D009473:Neuronal Plasticity; D020127:Recovery of Function; D013117:Spinal Cord Compression / Q000209:etiology / Q000503:physiopathology / Q000601:surgery; D013118:Spinal Cord Diseases / Q000150:complications / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology*; D013119:Spinal Cord Injuries / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology; D013128:Spinal Osteophytosis / Q000150:complications*