Reconstructing cellular lineages in endometrial cells.
We demonstrate that the cellular lineages and geographic relationship of endometrial cells from an endometrial tissue sample can be reconstructed using the molecular epigenetic clock, suggesting that the history of endometriotic lesions may be feasibly reconstructed by today's technology.
Wu
Yan
Y
Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226-0509, USA.
Guo
Sun-Wei
SW
D019070:Cell Lineage; D002999:Clone Cells; D016000:Cluster Analysis; D018899:CpG Islands / Q000502:physiology; D004247:DNA / Q000032:analysis; D019175:DNA Methylation; D004717:Endometrium / Q000502:physiology*; D005240:Feasibility Studies; D005260:Female; D005786:Gene Expression Regulation; D000072576:Homeobox Protein Nkx-2.5; D018398:Homeodomain Proteins / Q000235:genetics; D006801:Humans; D008954:Models, Biological; D017570:MyoD Protein / Q000235:genetics; D023822:Tissue Engineering / Q000379:methods*; D014157:Transcription Factors / Q000235:genetics
D000072576:Homeobox Protein Nkx-2.5; D018398:Homeodomain Proteins; D017570:MyoD Protein; C057363:MyoD1 myogenic differentiation protein; C095552:NKX2-5 protein, human; D014157:Transcription Factors; D004247:DNA