[How should we manage patients with elevated preoperative creatine kinase? --A case of CK productive lung cancer].
A 70-year-old man with lung cancer was scheduled for partial resection of the right lung. Preoperative serum creatine kinase was elevated (1808 IU x l(-1), CK-MM 97%). Acute coronary syndrome was denied by the absence of significant stenosis of coronary artery and the normal segmental wall motion in echocardiography. The other examinations did not reveal the cause of CK elevation. He did not receive dantlorene preoperatively, but the surgical procedure was performed uneventfully without the use of the triggering agents, such as volatile inhalational anesthetic gases and suxamethonium. Thoracic wall was not invaded by the tumor. After the operation, CK went down quickly. It decreased further after the postoperative chemotherapy. We concluded that CK elevation might have been produced by adenocarcinoma itself, judging from the rapid decrease after surgery and the absence of thoracic wall invasion. Though CK elevation may indicate the malignant hyperthermia, we should not delay the surgery too long when there is possibility of CK elevation derived from cancer itself.
Inoue
Tamaki
T
Department of Anesthesiology, Kansai-Denryoku Hospital, Osaka 553-0003.
Nakasuji
Masato
M
Takeuchi
Junko
J
Tsuji
Taisuke
T
Imanaka
Norie
N
Kawashima
Hiroko
H
D000368:Aged; D000768:Anesthesia, General; D052283:Creatine Kinase, MM Form / Q000096:biosynthesis*; D006801:Humans; D008175:Lung Neoplasms / Q000201:enzymology* / Q000601:surgery*; D008297:Male; D008305:Malignant Hyperthermia / Q000209:etiology / Q000517:prevention & control; D019990:Perioperative Care; D011013:Pneumonectomy; D013906:Thoracoscopy
D052283:Creatine Kinase, MM Form