title: Cytotype regulation by telomeric P elements in Drosophila melanogaster: interactions with P elements from M' strains.
abstract: P strains of Drosophila are distinguished from M strains by having P elements in their genomes and also by having the P cytotype, a maternally inherited condition that strongly represses P-element-induced hybrid dysgenesis. The P cytotype is associated with P elements inserted near the left telomere of the X chromosome. Repression by the telomeric P elements TP5 and TP6 is significantly enhanced when these elements are crossed into M' strains, which, like P strains, carry P elements, but have little or no ability to repress dysgenesis. The telomeric and M' P elements must coexist in females for this enhanced repression ability to develop. However, once established, it is transmitted maternally to the immediate offspring independently of the telomeric P elements themselves. Females that carry a telomeric P element but that do not carry M' P elements may also transmit an ability to repress dysgenesis to their offspring independently of the telomeric P element. Cytotype regulation therefore involves a maternally transmissible product of telomeric P elements that can interact synergistically with products from paternally inherited M' P elements. This synergism between TP and M' P elements also appears to persist for at least one generation after the TP has been removed from the genotype.
authors.affiliation: Department of Genetics, Cell Biology, and Development, 250 BioScience Center, University of Minnesota, 1445 Gortner Avenue, St. Paul, MN 55108-1095, USA. simmo004@umn.edu
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Simmons
authors.forename: Jarad B
authors.initials: JB
authors.lastname: Niemi
authors.forename: Don-Felix
authors.initials: DF
authors.lastname: Ryzek
authors.forename: Cecile
authors.initials: C
authors.lastname: Lamour
authors.forename: Joseph W
authors.initials: JW
authors.lastname: Goodman
authors.forename: Wojciech
authors.initials: W
authors.lastname: Kraszkiewicz
authors.forename: Ryan
authors.initials: R
authors.lastname: Wolff
mesh_terms: D000818:Animals; D003433:Crosses, Genetic; D004251:DNA Transposable Elements; D004331:Drosophila melanogaster / Q000235:genetics*; D005260:Female; D017344:Genes, Insect; D050172:Genes, X-Linked; D006059:Gonadal Dysgenesis / Q000235:genetics; D008297:Male; D016615:Telomere / Q000235:genetics
chemical_list: D004251:DNA Transposable Elements