title: Inhibition of lysine biosynthesis: an evolving antibiotic strategy.
abstract: Bacterial biosynthesis of lysine has come under increased scrutiny as a target for novel antibacterial agents as it provides lysine for protein synthesis and both lysine and meso-diaminopimelate for construction of the bacterial peptidoglycan cell wall. In this Highlight article we review recent advances in the validation of antibiotic targets, studies of the enzymes of the lysine biosynthetic pathway and development of inhibitors of these enzymes.
authors.affiliation: School of Chemistry, The University of Melbourne, Parkville, VIC 3010, Australia. chutton@unimelb.edu.au
authors.forename: Craig A
authors.initials: CA
authors.lastname: Hutton
authors.forename: Matthew A
authors.initials: MA
authors.lastname: Perugini
authors.forename: Juliet A
authors.initials: JA
authors.lastname: Gerrard
mesh_terms: D000591:Amino Acid Isomerases / Q000378:metabolism; D000594:Amino Acid Oxidoreductases / Q000378:metabolism; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D053898:Biosynthetic Pathways / Q000187:drug effects; D008239:Lysine / Q000096:biosynthesis* / Q000737:chemistry; D008954:Models, Biological; D015394:Molecular Structure
chemical_list: D000900:Anti-Bacterial Agents; D000594:Amino Acid Oxidoreductases; D000591:Amino Acid Isomerases; D008239:Lysine