[Association analysis of gene expression and gene function].
The pathway information in KEGG and the chromosome location in LocusLink, and three different similarity measurements are used to analyze the similarity of the mRNA expression level of genes which have strong correlative function with each other in a pathway and have near location with each other in the chromosome. The results are summarized as follows: (1) Quite a number of genes show significant correlation with other correlative genes at mRNA expression level. (2) The mRNA expression level is consistent with the intensity of functional relationships between genes. So it can be concluded that the function of genes involved in any pathway is correlated with the mRNA expression level of genes.
Xu
Na
N
Department of Bioinformatics, Harbin Medical University, Harbin 150086, China.
Lü
Sall
S
Li
Xia
X
Guo
Zheng
Z
Du
Lei
L
Gong
Binsheng
B
D000230:Adenocarcinoma / Q000235:genetics; D002874:Chromosome Mapping / Q000379:methods*; D003110:Colonic Neoplasms / Q000235:genetics*; D030541:Databases, Genetic; D020869:Gene Expression Profiling / Q000379:methods*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods; D012333:RNA, Messenger / Q000378:metabolism*
D012333:RNA, Messenger