title: Dopa-responsive pseudo-orthostatic tremor in parkinsonism.
abstract: In four patients an inabilitating standing tremor appeared years before that parkinsonian symptoms were evidenced. This tremor was refractory to gabapentin and dramatically responded to Levodopa administration. Its dominant frequency was 6.2 to 6.9 Hz with sporadic subharmonics at 8 to 18 Hz. Three patients were affected by different genetic mutations (Park 2, Park 6, mtDNA deletion) in one no genetic or metabolic alterations could be evidenced. All patients had dopamine transporter abnormalities. We suggest that the term "Pseudo-Orthostatic Tremor" could be used to define this Dopa responsive, 6 to 7 Hz standing tremor.
authors.affiliation: Department of Oncology and Neuroscience, Neurophysiopathology, University G. D'Annunzio Chieti-Pescara, Italy.
authors.forename: Astrid
authors.initials: A
authors.lastname: Thomas
authors.forename: Laura
authors.initials: L
authors.lastname: Bonanni
authors.forename: Angelo
authors.initials: A
authors.lastname: Antonini
authors.forename: Paolo
authors.initials: P
authors.lastname: Barone
authors.forename: Marco
authors.initials: M
authors.lastname: Onofrj
mesh_terms: D000328:Adult; D004295:Dihydroxyphenylalanine / Q000009:adverse effects*; D015259:Dopamine Agents / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020734:Parkinsonian Disorders / Q000188:drug therapy / Q000235:genetics; D014202:Tremor / Q000139:chemically induced* / Q000145:classification* / Q000235:genetics
chemical_list: D015259:Dopamine Agents; D004295:Dihydroxyphenylalanine