Outcome of pregnancy in women with congenital heart disease: a literature review.
A search of peer-reviewed literature was conducted to identify reports that provide data on complications associated with pregnancy in women with structural congenital heart disease (CHD). This review describes the outcome of 2,491 pregnancies, including 377 miscarriages (15%) and 114 elective abortions (5%). Important cardiac complications were seen in 11% of the pregnancies. Obstetric complications do not appear to be more prevalent. In complex CHD, premature delivery rates are high, and more children are small for gestational age. The offspring mortality was high throughout the spectrum and was related to the relatively high rate of premature delivery and recurrence of CHD.
Drenthen
Willem
W
Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands. w.drenthen@thorax.umcg.nl
Pieper
Petronella G
PG
Roos-Hesselink
Jolien W
JW
van Lottum
Willem A
WA
Voors
Adriaan A
AA
Mulder
Barbara J M
BJ
van Dijk
Arie P J
AP
Vliegen
Hubert W
HW
Yap
Sing C
SC
Moons
Philip
P
Ebels
Tjark
T
van Veldhuisen
Dirk J
DJ
D000022:Abortion, Spontaneous / Q000453:epidemiology; D000032:Abortion, Therapeutic / Q000706:statistics & numerical data; D000328:Adult; D001145:Arrhythmias, Cardiac / Q000453:epidemiology; D002303:Cardiac Output, Low / Q000453:epidemiology; D005260:Female; D006330:Heart Defects, Congenital / Q000453:epidemiology*; D006344:Heart Septal Defects, Atrial / Q000453:epidemiology; D006801:Humans; D006975:Hypertension, Portal / Q000453:epidemiology; D007752:Obstetric Labor, Premature / Q000453:epidemiology; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000453:epidemiology*; D011256:Pregnancy Outcome / Q000453:epidemiology*; D013771:Tetralogy of Fallot / Q000453:epidemiology; D013923:Thromboembolism / Q000453:epidemiology; D014188:Transposition of Great Vessels / Q000453:epidemiology