title: Catecholamine-induced stimulation of growth in Vibrio species.
abstract: OBJECTIVE
  To evaluate the effect of norepinephrine (NE) and related compounds on the growth of bacteria, we have examined the effect of the neuroendocrine hormone NE and related compounds on the growth of Vibrio parahaemolyticus and other human-pathogenic Vibrio species (Vibrio cholerae, Vibrio vulnificus, and Vibrio mimicus).
  
  
  RESULTS
  The effects on bacterial growth were examined using the serum-based medium and viable cells were counted using agar plates. We have shown that NE and its related compounds stimulate growth of V. parahaemolyticus in serum-based medium. This NE-induced growth stimulation was dependent upon the presence of transferrin. NE also stimulated growth of V. mimicus, but not V. cholerae and V. vulnificus.
  
  
  CONCLUSIONS
  These results suggest that the Vibrio species differ in their ability to respond to NE.
  
  
  CONCLUSIONS
  It is possible that NE and related compounds modulate the pathogenicity of V. parahaemolyticus and V. mimicus.
authors.affiliation: Department of Nutrition and Metabolism, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Nakano
authors.forename: A
authors.initials: A
authors.lastname: Takahashi
authors.forename: Y
authors.initials: Y
authors.lastname: Sakai
authors.forename: M
authors.initials: M
authors.lastname: Kawano
authors.forename: N
authors.initials: N
authors.lastname: Harada
authors.forename: K
authors.initials: K
authors.lastname: Mawatari
authors.forename: Y
authors.initials: Y
authors.lastname: Nakaya
mesh_terms: D000316:Adrenergic alpha-Agonists / Q000494:pharmacology*; D002395:Catecholamines / Q000494:pharmacology*; D003470:Culture Media / Q000737:chemistry / Q000494:pharmacology; D009638:Norepinephrine / Q000494:pharmacology*; D014168:Transferrin / Q000494:pharmacology; D014733:Vibrio / Q000187:drug effects* / Q000254:growth & development* / Q000472:pathogenicity; D014774:Virulence
chemical_list: D000316:Adrenergic alpha-Agonists; D002395:Catecholamines; D003470:Culture Media; D014168:Transferrin; D009638:Norepinephrine