Human herpesvirus 8 seroprevalence among prostate cancer case patients and control subjects.
To investigate a possible association between human herpesvirus 8 (HHV-8) and prostate cancer, we evaluated HHV-8 seroprevalence in 2 case-control studies. HHV-8 antibodies were detected by immunofluorescence with cells expressing lytic viral proteins and by enzyme immunoassays with recombinant viral structural protein (K8.1) and latent protein (latency-associated nuclear antigen-1; open reading frame 73), respectively. HHV-8 seroprevalence tended to be lower in patients with prostate cancer than in control subjects, but there was no significant difference in either study. These data imply that HHV-8 is not a major prevalent cause of prostate cancer.
Jenkins
F J
FJ
Department of Pathology, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA. fjenkins@pitt.edu
Hayes
R B
RB
Jackson
A
A
Pizza
G
G
Mbisa
G
G
Whitby
D
D
Goedert
J J
JJ
D000328:Adult; D001741:Black or African American; D000914:Antibodies, Viral / Q000032:analysis; D016022:Case-Control Studies; D004219:District of Columbia / Q000453:epidemiology; D006566:Herpesviridae Infections / Q000150:complications* / Q000453:epidemiology; D019288:Herpesvirus 8, Human / Q000472:pathogenicity*; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D011470:Prostatic Hyperplasia / Q000821:virology; D011471:Prostatic Neoplasms / Q000821:virology*; D016036:Seroepidemiologic Studies; D044465:White People
D000914:Antibodies, Viral