title: Genetic epidemiology, endophenotypes, and eating disorder classification.
abstract: OBJECTIVE
  To explore how genetic epidemiology has informed the identification of endophenotypes and how endophenotypes may inform future classification of eating disorders.
  
  
  METHODS
  Literature review and synthesis.
  
  
  RESULTS
  Although a number of endo- and subphenotypes have been suggested for eating disorders, few reach the rigorous definitions developed for candidate endophenotypes.
  
  
  CONCLUSIONS
  Further study of endophenotypes and subphenotypes for eating disorders may assist with developing a more homogenous classification system that more closely reflects underlying biological mechanisms, and provides a clearer focus for the development of coherent models and treatments.
authors.affiliation: Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7160, USA. cbulik@med.unc.edu
authors.forename: Cynthia M
authors.initials: CM
authors.lastname: Bulik
authors.forename: Johannes
authors.initials: J
authors.lastname: Hebebrand
authors.forename: Anna
authors.initials: A
authors.lastname: Keski-Rahkonen
authors.forename: Kelly L
authors.initials: KL
authors.lastname: Klump
authors.forename: Ted
authors.initials: T
authors.lastname: Reichborn-Kjennerud
authors.forename: Suzanne E
authors.initials: SE
authors.lastname: Mazzeo
authors.forename: Tracey D
authors.initials: TD
authors.lastname: Wade
mesh_terms: D000856:Anorexia Nervosa / Q000145:classification / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics; D052018:Bulimia Nervosa / Q000145:classification / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics; D001068:Feeding and Eating Disorders / Q000145:classification / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000453:epidemiology*; D006801:Humans; D010641:Phenotype