title: N-(6,7-dichloro-2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)-N-alkylsulfonamides as peripherally restricted N-methyl-D-aspartate receptor antagonists for the treatment of pain.
abstract: It has been hypothesized that peripherally restricted NMDA receptor antagonists may be effective analgesics for osteoarthritis pain. A class of novel quinoxalinedione atropisomers, first discovered for an NMDA receptor antagonist program for the treatment of stroke, was evaluated and further optimized with the goal of finding peripherally restricted NMDA receptor antagonists.
authors.affiliation: Pfizer Global Research and Development, Michigan Laboratories, 2800 Plymouth Road, Ann Arbor, MI 48105, USA. christopher.deur@pfizer.com
authors.forename: Christopher
authors.initials: C
authors.lastname: Deur
authors.forename: Arun K
authors.initials: AK
authors.lastname: Agrawal
authors.forename: Heidi
authors.initials: H
authors.lastname: Baum
authors.forename: John
authors.initials: J
authors.lastname: Booth
authors.forename: Susan
authors.initials: S
authors.lastname: Bove
authors.forename: Joan
authors.initials: J
authors.lastname: Brieland
authors.forename: Amy
authors.initials: A
authors.lastname: Bunker
authors.forename: Cleo
authors.initials: C
authors.lastname: Connolly
authors.forename: Joseph
authors.initials: J
authors.lastname: Cornicelli
authors.forename: JoAnn
authors.initials: J
authors.lastname: Dumin
authors.forename: Barry
authors.initials: B
authors.lastname: Finzel
authors.forename: Xinmin
authors.initials: X
authors.lastname: Gan
authors.forename: Sheila
authors.initials: S
authors.lastname: Guppy
authors.forename: Gregg
authors.initials: G
authors.lastname: Kamilar
authors.forename: Kenneth
authors.initials: K
authors.lastname: Kilgore
authors.forename: Pil
authors.initials: P
authors.lastname: Lee
authors.forename: Cho-Ming
authors.initials: CM
authors.lastname: Loi
authors.forename: Zhen
authors.initials: Z
authors.lastname: Lou
authors.forename: Mark
authors.initials: M
authors.lastname: Morris
authors.forename: Laurence
authors.initials: L
authors.lastname: Philippe
authors.forename: Sally
authors.initials: S
authors.lastname: Przybranowski
authors.forename: Frank
authors.initials: F
authors.lastname: Riley
authors.forename: Brian
authors.initials: B
authors.lastname: Samas
authors.forename: Brian
authors.initials: B
authors.lastname: Sanchez
authors.forename: Haile
authors.initials: H
authors.lastname: Tecle
authors.forename: Ziqiang
authors.initials: Z
authors.lastname: Wang
authors.forename: Kathryn
authors.initials: K
authors.lastname: Welch
authors.forename: Michael
authors.initials: M
authors.lastname: Wilson
authors.forename: Karen
authors.initials: K
authors.lastname: Yates
mesh_terms: D000700:Analgesics / Q000737:chemistry* / Q000494:pharmacology*; D000818:Animals; D019540:Area Under Curve; D001665:Binding Sites; D008958:Models, Molecular; D015394:Molecular Structure; D010146:Pain / Q000188:drug therapy; D011485:Protein Binding; D051381:Rats; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000097:blood / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000700:Analgesics; D016194:Receptors, N-Methyl-D-Aspartate; D013449:Sulfonamides