title: [Individual cytogenetic and molecular-biological characteristics of lymphocytes in blood of pilots and cosmonauts].
abstract: The purpose of this paper was the investigation of the pilots and of cosmonauts individual sensitivity to the fly conditions, to the additional irradiation (in the dose of 1 Gy), the adaptive response manifestation (in the doses 0.05 and 0.5 Gy). The DNA comet assay (the double strand DNA breaks was determined) and the method of unstable chromosome aberrations in metaphase was used. The human blood lymphocytes was the object of investigation. The significant individual differences were discovered in pilots and in cosmonauts in the initial DNA damage; in the sensitivity to the additional irradiation. The frequency of the adaptive response induction was decreased in the pilots in the comparison with the control group. The adaptive response was registered in cosmonauts (3 men). It is supposed that DNA damage, chromosome aberrations, sensitivity to the additional irradiation, the adaptive response manifestations can be used as biological markers of individual risk disease.
authors.forename: I I
authors.initials: II
authors.lastname: Pelevina
authors.forename: M M
authors.initials: MM
authors.lastname: Antoshchina
authors.forename: V A
authors.initials: VA
authors.lastname: Bondarenko
authors.forename: N Iu
authors.initials: NIu
authors.lastname: Vorob'eva
authors.forename: Iu I
authors.initials: IuI
authors.lastname: Voronkov
authors.forename: V Ia
authors.initials: VIa
authors.lastname: Gotlib
authors.forename: O V
authors.initials: OV
authors.lastname: Kudriashova
authors.forename: A N
authors.initials: AN
authors.lastname: Osipov
authors.forename: N I
authors.initials: NI
authors.lastname: Riabchenko
authors.forename: A M
authors.initials: AM
authors.lastname: Serebrianyĭ
authors.forename: V V
authors.initials: VV
authors.lastname: Tsetlin
mesh_terms: D000222:Adaptation, Physiological / Q000235:genetics / Q000528:radiation effects; D000328:Adult; D018480:Astronauts; D002869:Chromosome Aberrations / Q000528:radiation effects*; D020552:Comet Assay; D004249:DNA Damage; D004305:Dose-Response Relationship, Drug; D005720:Gamma Rays; D006801:Humans; D008214:Lymphocytes / Q000528:radiation effects*; D008297:Male; D016273:Occupational Exposure / Q000009:adverse effects; D011829:Radiation Dosage