Severe phimosis as a notable sequela of allogeneic stem cell transplantation in boys.
Hematopoietic SCT has improved the survival rates of patients with hematologic and metabolic disorders, as well as those with malignancy or immunodeficiency. Although various complications have been reported following allogeneic SCT, phimosis has rarely been reported, and the predisposing risk factors for phimosis have not been determined. In this study, the occurrence of severe phimosis following allogeneic SCT in boys was analyzed, and its risk factors were determined. The patients were under 15 years of age. Phimosis was observed in 32.6% of 46 patients after allogeneic SCT; 13.0% of cases required surgery. On univariate analysis, risk factors for severe phimosis included chronic GVHD and the use of a conditioning regimen including anti-thymocyte globulin (ATG). Multivariate analysis showed that chronic GVHD was an independent risk factor for severe phimosis. Thus, severe phimosis is an important complication of SCT in boys, especially in patients with chronic GVHD.
Suzuki
D
D
Department of Pediatrics, Hokkaido University Graduate School of Medicine, North 15-West 7, Kita-ku, Sapporo 060-8638, Japan. chashu@med.hokudai.ac.jp
Kobayashi
R
R
Kaneda
M
M
Sato
T
T
Ichikawa
M
M
Ariga
T
T
D000293:Adolescent; D000961:Antilymphocyte Serum / Q000009:adverse effects; D002648:Child; D002675:Child, Preschool; D006086:Graft vs Host Disease / Q000150:complications*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D007223:Infant; D007564:Japan; D008297:Male; D010688:Phimosis / Q000209:etiology*; D012189:Retrospective Studies; D012307:Risk Factors; D014184:Transplantation, Homologous
D000961:Antilymphocyte Serum