title: Tarennane and tarennone, two novel chalcone constituents from Tarenna attenuata.
abstract: Two novel chalcone constituents, tarennane (1) and tarennone (2), together with nine known compounds, were isolated from the whole plant of Tarenna attenuata. By analysis of physical and spectroscopic data, the structures of new compounds were elucidated as (E)-4-[3-(4-hydroxy-3-methoxyphenyl)-acryl]-3,4,5-trimethoxycyclohexa-2,5-dienone (1) and 1,2-bis(3,5-dimethoxy-4-hydroxyphenyl)-3-hydroxypropan-1-one (2). These two compounds were tested for antioxidant activities in the MTT and DPPH assays. Compound 1 revealed potent antioxidant activities against H2O2-induced impairment in PC12 cells, but neither of them showed DPPH radical-scavenging activity with IC50 values of 181.1 and 210.3 microM, respectively.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, People's Republic of China.
authors.forename: Xian-Wen
authors.initials: XW
authors.lastname: Yang
authors.forename: Jun-Song
authors.initials: JS
authors.lastname: Wang
authors.forename: Yue-Hu
authors.initials: YH
authors.lastname: Wang
authors.forename: Hai-Tao
authors.initials: HT
authors.lastname: Xiao
authors.forename: Xu-Jia
authors.initials: XJ
authors.lastname: Hu
authors.forename: Shu-Zhen
authors.initials: SZ
authors.lastname: Mu
authors.forename: Yan-Lin
authors.initials: YL
authors.lastname: Ma
authors.forename: Hua
authors.initials: H
authors.lastname: Lin
authors.forename: Hong-Ping
authors.initials: HP
authors.lastname: He
authors.forename: Ling
authors.initials: L
authors.lastname: Li
authors.forename: Xiao-Jiang
authors.initials: XJ
authors.lastname: Hao
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D047188:Chalcones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D019906:Nuclear Magnetic Resonance, Biomolecular; D016716:PC12 Cells; D051381:Rats; D019666:Rubiaceae / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D047188:Chalcones; C521780:tarennane; C521779:tarennone