title: Hemorrhage after particle embolization of hemangioblastomas: comparison of outcomes in spinal and cerebellar lesions.
abstract: OBJECTIVE
  In this study the authors compare the clinical outcomes after particle embolization of hemangioblastomas in the cerebellum and spinal cord. They also review the literature of similar cases.
  
  
  METHODS
  Seven patients with hemangioblastomas in the spinal cord (four patients) and cerebellum (three patients) underwent preoperative embolization at the authors' center. Magnetic resonance imaging and selective angiography studies as well as histological diagnoses were available in all patients. Embosphere particles (trisacryl gelatin micro-spheres) were used in all cases. The smallest particle diameter ranged from 100 to 300 microm at the beginning of embolization in all patients. The outcome of embolization was favorable in patients with spinal cord hemangioblastomas, but it was unfavorable for those with cerebellar hemangioblastomas; acute tumor bleeding and death occurred in all of the latter cases. The outcomes following embolization are very different for these two locations possibly because of the different capillary sizes.
  
  
  CONCLUSIONS
  The authors no longer use particle embolization to treat cerebellar hemangioblastomas.
authors.affiliation: Departments of Neurosurgery, Lariboisibre Hospital, Paris, France.
authors.forename: Jan Frédérick
authors.initials: JF
authors.lastname: Cornelius
authors.forename: Jean Pierre
authors.initials: JP
authors.lastname: Saint-Maurice
authors.forename: Damien
authors.initials: D
authors.lastname: Bresson
authors.forename: Bernard
authors.initials: B
authors.lastname: George
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Houdart
mesh_terms: D000328:Adult; D000368:Aged; D002528:Cerebellar Neoplasms / Q000628:therapy*; D002533:Cerebral Angiography; D002543:Cerebral Hemorrhage / Q000209:etiology* / Q000503:physiopathology; D004621:Embolization, Therapeutic / Q000009:adverse effects*; D005260:Female; D018325:Hemangioblastoma / Q000628:therapy*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010316:Particle Size; D011183:Postoperative Complications / Q000209:etiology* / Q000503:physiopathology; D012189:Retrospective Studies; D013125:Spinal Neoplasms / Q000628:therapy*; D016896:Treatment Outcome