title: Gastrointestinal stromal tumors involving the prostate: presentation, course, and therapeutic approach.
abstract: Gastrointestinal stromal tumors are relatively rare soft-tissue neoplasms arising from the gastrointestinal tract. The clinical presentation of gastrointestinal stromal tumors varies and depends on the tumor size and location. We present 2 patients with a gastrointestinal stromal tumor who presented with genitourinary symptoms and were diagnosed by transrectal ultrasound-guided prostate biopsy. We describe the clinical presentation and diagnostic and therapeutic approach to these cases, highlighting the successful preoperative use of imatinib mesylate (Gleevec) followed by prostatectomy.
authors.affiliation: Department of Internal Medicine, Division of Hematology/Oncology, Ohio State University, Columbus, Ohio 43210-1280, USA. carlos.arce-lara@osumc.edu
authors.forename: Carlos
authors.initials: C
authors.lastname: Arce-Lara
authors.forename: Manisha H
authors.initials: MH
authors.lastname: Shah
authors.forename: Rafael E
authors.initials: RE
authors.lastname: Jimenez
authors.forename: Vipul R
authors.initials: VR
authors.lastname: Patel
authors.forename: Don M
authors.initials: DM
authors.lastname: Benson
authors.forename: Steven K
authors.initials: SK
authors.lastname: Clinton
authors.forename: J Paul
authors.initials: JP
authors.lastname: Monk
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D001549:Benzamides; D001707:Biopsy, Needle; D046152:Gastrointestinal Stromal Tumors / Q000175:diagnosis / Q000188:drug therapy / Q000556:secondary*; D006801:Humans; D000068877:Imatinib Mesylate; D008297:Male; D008875:Middle Aged; D009382:Neoplasms, Unknown Primary; D010879:Piperazines / Q000627:therapeutic use; D011471:Prostatic Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000556:secondary*; D011743:Pyrimidines / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D001549:Benzamides; D010879:Piperazines; D011743:Pyrimidines; D000068877:Imatinib Mesylate