title: Real-time quantitative imaging of submolecular layers.
abstract: Using a recent optical contrast method, real-time and quantitative imaging of submolecular layers was performed with the help of a simple optical microscope. The measuring technique is exposed and documented by three examples. In particular, it allowed label-free detection of peptide-antibody binding interactions with 50 pg/mm2 sensitivity while keeping full optical lateral resolution.
authors.affiliation: Laboratoire de Physique de l'Etat Condensé (UMR 6087), Université du Maine, CNRS, Route de Laval, 72000 Le Mans, France. ausserre@univ-lemans.fr
authors.forename: Dominique
authors.initials: D
authors.lastname: Ausserré
authors.forename: Refahi Abou
authors.initials: RA
authors.lastname: Khachfe