Synthesis of nitric oxide reductase active site models bearing key components at both distal and proximal sites.
Porphyrins 1ab and 2ab were successfully synthesized from cis-alpha2-bisimidazole-beta-imidazole-tail porphyrins and two newly synthesized imidazole pickets containing an aliphatic ester chain following a [2+1] approach. The four compounds possess a distal trisimidazole set, a distal carboxylic acid, and a proximal imidazole, which constitute all the key features of the coordination environment of the active site in Bacterial Nitric Oxide Reductase (NOR) and make them the closest synthetic NOR model ligands to date.
Collman
James P
JP
Department of Chemistry, Stanford University, Stanford, California 94305-5080, USA. jpc@stanford.edu
Yang
Ying
Y
Decréau
Richard A
RA
D001665:Binding Sites; D008958:Models, Molecular; D010088:Oxidoreductases / Q000138:chemical synthesis* / Q000737:chemistry
D010088:Oxidoreductases; C034747:nitric-oxide reductase