APRIL in the intestine: a good destination for immunoglobulin A(2).
Immunoglobulin A (IgA) confers mucosal protection against bacteria in the intestine. In this issue, He et al. (2007) find that bacterial molecules promote IgA(2) generation via the cytokine APRIL, produced by intestinal epithelial and dendritic cells.
Macpherson
Andrew J
AJ
Department of Medicine, McMaster University Medical Centre, Hamilton, Ontario, Canada. macpher@mcmaster.ca
McCoy
Kathy
K
D001419:Bacteria / Q000276:immunology*; D001426:Bacterial Proteins / Q000276:immunology; D006801:Humans; D007070:Immunoglobulin A / Q000276:immunology*; D007413:Intestinal Mucosa / Q000276:immunology* / Q000382:microbiology; D007422:Intestines / Q000276:immunology / Q000382:microbiology; D053300:Tumor Necrosis Factor Ligand Superfamily Member 13 / Q000502:physiology*
D001426:Bacterial Proteins; D007070:Immunoglobulin A; D053300:Tumor Necrosis Factor Ligand Superfamily Member 13