title: Endiandrin A, a potent glucocorticoid receptor binder isolated from the Australian plant Endiandra anthropophagorum.
abstract: Bioassay-guided fractionation of the DCM extract from the roots of Endiandra anthropophagorum resulted in the isolation of a new cyclobutane lignan, endiandrin A (1), together with the known natural products nectandrin B (2) and (-)-dihydroguaiaretic acid (3). The structure of 1 was determined by extensive 1D and 2D NMR and MS data analyses. Acetylation and methylation of 1 yielded di-O-acetylendiandrin A (4) and di-O-methylendiandrin A (5), respectively. All compounds were tested in a glucocorticoid receptor binding assay and displayed IC50 values ranging from 0.9 to 35 microM.
authors.affiliation: Eskitis Institute, Griffith University, Brisbane, QLD 4111, Australia.
authors.forename: Rohan A
authors.initials: RA
authors.lastname: Davis
authors.forename: Anthony R
authors.initials: AR
authors.lastname: Carroll
authors.forename: Sandra
authors.initials: S
authors.lastname: Duffy
authors.forename: Vicky M
authors.initials: VM
authors.lastname: Avery
authors.forename: Gordon P
authors.initials: GP
authors.lastname: Guymer
authors.forename: Paul I
authors.initials: PI
authors.lastname: Forster
authors.forename: Ronald J
authors.initials: RJ
authors.lastname: Quinn
mesh_terms: D001315:Australia; D003503:Cyclobutanes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D019770:Lauraceae / Q000737:chemistry*; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011965:Receptors, Glucocorticoid / Q000187:drug effects*
chemical_list: D003503:Cyclobutanes; D017705:Lignans; D011965:Receptors, Glucocorticoid; C522142:endiandrin A