Immunogenicity of reduced antigen content tetanus-diphtheria-acellular pertussis vaccine in adolescents as a sixth consecutive dose of acellular pertussis-containing vaccine.
Three hundred and nineteen adolescents aged 10-12 years who had been previously vaccinated with five doses of acellular pertussis-containing vaccines received single doses of Tdap (reduced-antigen-content tetanus, diphtheria, acellular pertussis) and hepatitis A vaccines in a double-blind crossover trial. Long-term antibody persistence following vaccination with Tdap at pre-school age was similar to that following vaccination with DTaP (diphtheria-tetanus-acellular pertussis). After the sixth dose booster, Tdap induced a vigorous immune response, consistent with protection against diphtheria, tetanus and pertussis diseases.
Zepp
Fred
F
Children's Hospital, Johannes Gutenberg University, Langenbeckstrasse 1, 55101 Mainz, Germany. zepp@kinder.klinik.uni-mainz.de
Habermehl
Pirmin
P
Knuf
Markus
M
Mannhardt-Laakman
Wilma
W
Howe
Barbara
B
Friedland
Leonard R
LR
D000907:Antibodies, Bacterial / Q000097:blood; D000942:Antigens, Bacterial / Q000276:immunology*; D002648:Child; D004165:Diphtheria / Q000517:prevention & control; D022681:Diphtheria-Tetanus-acellular Pertussis Vaccines / Q000008:administration & dosage* / Q000276:immunology*; D004311:Double-Blind Method; D005260:Female; D022362:Hepatitis A Vaccines / Q000008:administration & dosage / Q000276:immunology; D006801:Humans; D007117:Immunization, Secondary / Q000379:methods*; D008297:Male; D013742:Tetanus / Q000517:prevention & control; D013997:Time Factors; D014917:Whooping Cough / Q000517:prevention & control
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D022681:Diphtheria-Tetanus-acellular Pertussis Vaccines; D022362:Hepatitis A Vaccines