title: Systematic review: maintenance treatment of gastro-oesophageal reflux disease with proton pump inhibitors taken 'on-demand'.
abstract: BACKGROUND
  Proton pump inhibitors (PPI) therapy 'on-demand' is often used as an alternative to continuous maintenance therapy in gastro-oesophageal reflux disease (GERD).
  
  
  OBJECTIVE
  We conducted a systematic review with the specific objectives to ascertain whether on-demand PPI therapy was effective in preventing symptomatic relapse and to assess the relative efficacy of on-demand vs. continuous PPI maintenance strategy.
  
  
  METHODS
  Randomized-controlled clinical trials comparing on-demand PPI vs. placebo or on-demand vs. continuous PPI therapy in GERD patients were identified by searching the Medline database and the Cochrane Controlled Trials Register.
  
  
  RESULTS
  Seventeen studies were found which met inclusion criteria. Out of the 17 studies: five investigated exclusively patients with non-erosive reflux disease (NERD), four patients with NERD and mild oesophagitis, two patients with erosive oesophagitis only, and two patients with uninvestigated GERD symptoms, respectively. Four further studies were not investigating the effectiveness of the therapies but primarily pharmacoeconomic or quality of life parameters.
  
  
  CONCLUSIONS
  On the basis of the analysis of 17 studies, we can conclude that on-demand therapy with currently available PPI appears to be effective in the long-term management of patients with NERD or mild and uninvestigated forms of GERD, but not in patients with (severe) erosive oesophagitis.
authors.affiliation: Division of Gastroenterology, L. Sacco University Hospital, University of Milan, Italy. fabio.pace@unimi.it
authors.forename: F
authors.initials: F
authors.lastname: Pace
authors.forename: M
authors.initials: M
authors.lastname: Tonini
authors.forename: S
authors.initials: S
authors.lastname: Pallotta
authors.forename: P
authors.initials: P
authors.lastname: Molteni
authors.forename: G B
authors.initials: GB
authors.lastname: Porro
mesh_terms: D004334:Drug Administration Schedule; D004941:Esophagitis / Q000188:drug therapy*; D005764:Gastroesophageal Reflux / Q000188:drug therapy*; D006801:Humans; D054328:Proton Pump Inhibitors; D017494:Proton Pumps / Q000008:administration & dosage; D016032:Randomized Controlled Trials as Topic; D055502:Secondary Prevention
chemical_list: D054328:Proton Pump Inhibitors; D017494:Proton Pumps