Chronic rhinosinusitis and psoriasis: do mutually exclusive systemic Th1 and Th2 disease patterns exist?
CONCLUSIONS
Our results support the theory that chronic rhinosinusitis (CRS) is a systemic Th alteration, the relevance of which is discussed in detail.


OBJECTIVE
CRS imposes a heavy burden on society; however, a reliable CRS therapy has not been found. Developing a better understanding of this pathology will help us in our search for more effective therapies. One question, which is rarely examined, is the possibility of CRS existing as a systemic immune alteration in Th response. Thus, the goal of this study was to examine the occurrence of CRS, a Th2 pathology, with Th1 pathologies such as psoriasis.


METHODS
This study was performed via a retrospective electronic query of our medical center in regards to patients coded with the respective diagnosis.


RESULTS
Analysis of the data showed that occurrence of CRS rarely coincided with the occurrence of psoriasis and other such Th1 pathologies.
Rashid
Rashid M
RM
MD PhD Department, Loyola University, Maywood, IL 60153, USA. Rrashid@lumc.edu
Miller
Andrew
A
Scianna
Joseph M
JM
Stankiewicz
James A
JA
D001172:Arthritis, Rheumatoid / Q000276:immunology; D002908:Chronic Disease; D003424:Crohn Disease / Q000276:immunology; D006801:Humans; D009103:Multiple Sclerosis / Q000276:immunology; D011565:Psoriasis / Q000276:immunology*; D012189:Retrospective Studies; D012220:Rhinitis / Q000276:immunology*; D012852:Sinusitis / Q000276:immunology*; D018417:Th1 Cells / Q000276:immunology*; D018418:Th2 Cells / Q000276:immunology*