title: [Association between serotonin 4 gene polymorphisms and attention deficit hyperactivity disorder comorbid or not comorbid disruptive behavioral disorder].
abstract: OBJECTIVE
  To investigate the relationship between three HTR4 gene polymorphisms, 83097 C>T, 83198 A>G as well as -36C>T polymorphisms, and attention deficit hyperactivity disorder (ADHD) comorbid or not comorbid disruptive behavioral disorder (DBD).
  
  
  METHODS
  Blood samples were taken from 152 trios with probands of ADHD comorbid DBD and 173 trios with probands of ADHD not comorbid DBD. DNA was extracted. 83097 C>T, 83198 A>G and -36C>T were genotyped by restriction fragment length polymorphism analysis. Transmit/disequilibrium test and haplotype analysis were used to test the association of the three polymorphisms with ADHD comorbid or not comorbid DBD separately.
  
  
  RESULTS
  Haplotype T/G/T showed tendency of over transmission (chi(2)=3.470,P=0.062) to probands of ADHD with DBD, while haplotype C/G/T (chi(2)=4.568,P=0.032) and C/G/C (chi(2)=5.333,P=0.021) were under transmitted to probands of ADHD without DBD, No biased transmissions of any allele were found in families with probands of ADHD with and without DBD.
  
  
  CONCLUSIONS
  Whether ADHD comorbid DBD or not comorbid DBD makes difference at the level of HTR4 gene polymorphisms.
authors.affiliation: Institute of Mental Health, Peking University, Beijing 10083, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.forename: Yu-feng
authors.initials: YF
authors.lastname: Wang
authors.forename: Ru-lun
authors.initials: RL
authors.lastname: Zhou
authors.forename: Li
authors.initials: L
authors.lastname: Yang
authors.forename: Hao-bo
authors.initials: HB
authors.lastname: Zhang
authors.forename: Bing
authors.initials: B
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D019958:Attention Deficit and Disruptive Behavior Disorders / Q000453:epidemiology / Q000235:genetics*; D002648:Child; D015897:Comorbidity; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D011110:Polymorphism, Genetic; D044422:Receptors, Serotonin, 5-HT4 / Q000235:genetics*
chemical_list: D044422:Receptors, Serotonin, 5-HT4