title: A longitudinal study on the effects of typical versus atypical antipsychotic drugs on hippocampal volume in schizophrenia.
abstract: BACKGROUND
  Previous studies have reported that hippocampal volumes correlate with symptom severity in schizophrenia. This longitudinal study measured changes in symptoms and hippocampal volume in patients switched from typical antipsychotics to olanzapine.
  
  
  METHODS
  MRI scans were acquired from patients with chronic schizophrenia (n=10) and healthy volunteers (n=20). At baseline, patients were treated with typical antipsychotics for at least one year, then switched to olanzapine, and rescanned approximately one year later.
  
  
  RESULTS
  Olanzapine treatment resulted in no significant change in right or left hippocampal volume. Individual changes in right hippocampal volume correlated significantly with changes in symptoms.
  
  
  CONCLUSIONS
  Hippocampal volume change may serve as a marker of symptom change in patients on olanzapine.
authors.affiliation: Department of Psychiatry, University of British Columbia, 828 West 10th Ave, Vancouver, BC, Canada, V5Z 1L8. williampanenka@hotmail.com
authors.forename: William J
authors.initials: WJ
authors.lastname: Panenka
authors.forename: Babak
authors.initials: B
authors.lastname: Khorram
authors.forename: Alasdair M
authors.initials: AM
authors.lastname: Barr
authors.forename: Geoffrey N
authors.initials: GN
authors.lastname: Smith
authors.forename: Donna J
authors.initials: DJ
authors.lastname: Lang
authors.forename: Lili C
authors.initials: LC
authors.lastname: Kopala
authors.forename: Robert A
authors.initials: RA
authors.lastname: Vandorpe
authors.forename: William G
authors.initials: WG
authors.lastname: Honer
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D001569:Benzodiazepines / Q000494:pharmacology / Q000627:therapeutic use; D002908:Chronic Disease; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D005500:Follow-Up Studies; D006624:Hippocampus / Q000033:anatomy & histology* / Q000187:drug effects*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D000077152:Olanzapine; D012559:Schizophrenia / Q000175:diagnosis* / Q000188:drug therapy*
chemical_list: D014150:Antipsychotic Agents; D001569:Benzodiazepines; D000077152:Olanzapine