Estimation of baseline dopamine D2 receptor occupancy in striatum and extrastriatal regions in humans with positron emission tomography with [18F] fallypride.
BACKGROUND
This study examined whether positron emission tomography (PET) studies with [18F] fallypride performed before and after alpha-methyl-para-tyrosine (AMPT) administration can be used to estimate baseline dopamine (DA) D2 receptor occupancy in striatal and extrastriatal regions.


METHODS
Six normal subjects underwent PET with [18 F] fallypride before and after administration of AMPT. The DA D2 receptor binding potentials (bp) were calculated with the reference region method. Percent changes in bp in striatal and extrastriatal regions were calculated with both region-of-interest analysis and on a voxel by voxel basis with parametric images of DA D2 receptor levels.


RESULTS
The results of the current study indicate that AMPT treatment significantly increased the bp in the caudate, putamen, ventral striatum, and substantia nigra. A trend level increase was seen in the medial thalamus.


CONCLUSIONS
This study demonstrates that PET with [18F] fallypride can be used to estimate baseline DA D2 receptor occupancy in striatal and extrastriatal regions.
Riccardi
Patrizia
P
Department of Radiology, Vanderbilt University, Nashville, Tennessee 37232-2675, USA.
Baldwin
Ron
R
Salomon
Ronald
R
Anderson
Sharlet
S
Ansari
Mohammad S
MS
Li
Rui
R
Dawant
Benoit
B
Bauernfeind
Amy
A
Schmidt
Dennis
D
Kessler
Robert
R
D000328:Adult; D001549:Benzamides / Q000378:metabolism*; D001931:Brain Mapping; D003342:Corpus Striatum / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008297:Male; D049268:Positron-Emission Tomography; D011759:Pyrrolidines / Q000378:metabolism*; D011869:Radioligand Assay; D017448:Receptors, Dopamine D2 / Q000378:metabolism*
D001549:Benzamides; C094948:N-((1-allyl-2-pyrrolidinyl)methyl)-5-(3-fluoropropyl)-2,3-dimethoxybenzamide; D011759:Pyrrolidines; D017448:Receptors, Dopamine D2