title: Malignant transformation of intracranial mature teratoma to yolk sac tumor after late relapse. Case report.
abstract: The recurrence of intracranial mature teratomas as germ cell tumors of different histological types is rarely reported. The authors describe the first case of the malignant transformation of an intracranial mature teratoma into a yolk sac tumor in a 16-year-old boy who presented with a 1-month history of anorexia and somnolence. Seven years prior to this presentation, the boy had undergone surgery for extirpation of a mature pineal teratoma. Computed tomography images obtained at his second presentation revealed a homogeneously enhanced mass within the third ventricle. The tumor was resected and the results of a histological examination were consistent with a yolk sac tumor. After resection, the patient underwent radiation therapy followed by chemotherapy with cisplatin and etoposide but died of tumor progression 15 months after his second hospitalization.
authors.affiliation: Department of Neurosurgery, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan. utsuki@med.kitasato-u.ac.jp
authors.forename: Satoshi
authors.initials: S
authors.lastname: Utsuki
authors.forename: Hidehiro
authors.initials: H
authors.lastname: Oka
authors.forename: Takao
authors.initials: T
authors.lastname: Sagiuchi
authors.forename: Satoru
authors.initials: S
authors.lastname: Shimizu
authors.forename: Sachio
authors.initials: S
authors.lastname: Suzuki
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Fujii
mesh_terms: D001932:Brain Neoplasms / Q000473:pathology*; D002648:Child; D003131:Combined Modality Therapy; D018240:Endodermal Sinus Tumor / Q000473:pathology* / Q000601:surgery*; D017809:Fatal Outcome; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009364:Neoplasm Recurrence, Local; D010871:Pinealoma / Q000473:pathology / Q000601:surgery; D013724:Teratoma / Q000473:pathology* / Q000601:surgery*; D014057:Tomography, X-Ray Computed