title: Antimicrobial activity of a series of thiosemicarbazones and their Zn(II) and Pd(II) complexes.
abstract: Thirty-four thiosemicarbazones and S-alkyl thiosemicarbazones, and some of their Zn(II) and Pd(II) complexes were obtained and purified to investigate antimicrobial activity. MIC values of the compounds were determined by the disc diffusion method against Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa, Salmonella typhi, Shigella flexneri, Staphylococcus aureus, S. epidermidis, and Candida albicans. The thiosemicarbazones show antibacterial and antifungal effects in free ligand and metal-complex form. Picolinaldehyde-S-methyl- and -S-benzylthiosemicarbazones did not affect the tested microorganisms but their Zn(II) complexes showed selective activity. The antimicrobial activity is relatively high in Me2SO, but the antimicrobial potential is changed in a certain range with Me2SO, HCONMe2, EtOH and CHCl3.
authors.affiliation: Department of Chemistry, Istanbul University, Avcilar, Istanbul, Turkey. irfank@istanbul.edu.tr
authors.forename: I
authors.initials: I
authors.lastname: Kizilcikli
authors.forename: Y D
authors.initials: YD
authors.lastname: Kurt
authors.forename: B
authors.initials: B
authors.lastname: Akkurt
authors.forename: A Y
authors.initials: AY
authors.lastname: Genel
authors.forename: S
authors.initials: S
authors.lastname: Birteksöz
authors.forename: G
authors.initials: G
authors.lastname: Otük
authors.forename: B
authors.initials: B
authors.lastname: Ulküseven
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D002176:Candida albicans / Q000187:drug effects*; D007854:Lead / Q000737:chemistry*; D008024:Ligands; D008826:Microbial Sensitivity Tests / Q000379:methods; D012997:Solvents / Q000737:chemistry / Q000494:pharmacology; D013882:Thiosemicarbazones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D015032:Zinc / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D008024:Ligands; D012997:Solvents; D013882:Thiosemicarbazones; D007854:Lead; D015032:Zinc