The effect of prolactin on cyclosporin in renal transplant patients.
The modulation of the immune response by interaction of prolactin and cyclosporin has been investigated in a total of 181 subjects, 121 males and 60 females. This study demonstrates a significant difference in the magnitude and fluctuation in prolactin and cyclosporin concentrations between males and females receiving cyclosporin as the single immunosuppressant. Levels of both analytes are lower in the male and show markedly less fluctuation than in the female. It is proposed that prolactin levels should be taken into account when determining the appropriate dosage regimen of cyclosporin in those patients receiving cyclosporin alone as immunosuppressant therapy.
Joyce
B G
BG
Departments of Pathology and Nephrology, Riyadh Armed Forces Hospital, Riyadh, Saudi Arabia.
Bacchus
R
R
Suleiman
M H
MH
Dhar
J M
JM
Al-Khader
A A
AA