Role of flavonoids and vitamins in cancer.
Flavonoids are naturally occurring polyphenolic plant compounds that are capable of inhibiting histamine and cytokine release from several cells. Many studies suggest that flavonoids are anticancer agents with an apoptotic effect on tumor cells. Studies with animal tumour models have found vitamin deficiency to enhance susceptibility to chemical carcinogenesis and large doses of anti-oxidant vitamins and flavonoids to inhibit carcinogenesis. In some studies flavonoids and/or vitamins were found to reduce the predisposition to develop tumours in animals and humans. In conclusion, in this review we describe the role of flavonoids and vitamins in cancer.
Castellani
Maria Luisa
ML
Department of Medicine and Aging, Medical School, University of Chieti-Pescara, Via dei Vestini, Chieti, Italy.
Shaik
Yazdani B
YB
Shanmugham
Lakshmi Narayan
LN
Frydas
Stavros
S
Madhappan
Bhuvaneshwari
B
Salini
Vincenzo
V
Vecchiet
Jacopo
J
Mastrangelo
Filiberto
F
Riccioni
Graziano
G
Conti
Fiorella
F
Perrella
Alessandro
A
Conti
Pio
P
Tetè
Stefano
S
D000818:Animals; D005419:Flavonoids / Q000627:therapeutic use*; D006801:Humans; D009369:Neoplasms / Q000517:prevention & control*; D014815:Vitamins / Q000627:therapeutic use*
D005419:Flavonoids; D014815:Vitamins