[Place of artemisinin derivatives as anti-malarial drugs in paediatric hospitalization in Abidjan].
The objective of this study is to analyze anti-malaria treatment and to appreciate the place of artemisinin and its derivatives in order to research rationality of prescriptions in paediatric hospitalization in Abidjan (Côte d'Ivoire). The investigation is based on a descriptive analysis related to 415 medical files constituting 646 prescriptions in four hospital centers. We considered therapeutic recommendations of PNLP (National Program Against Malaria) to analyse these prescriptions. The correspondence factorial analysis has been used to appreciate different correlations between anti-malaria drug use and type of malaria, patients' age, hospital... Artemisinin derivatives constitute the third of anti-malaria drugs prescribed to children. They are represented by artemether (most used), artesunate and artemether-lumefantrine combination. The treatment in emergency remains dominated by quinine. Amodiaquine and artesunate are the principal relay treatment with the detriment of chloroquine. Quinine remains the treatment of choice in paediatric hospitalization in complicated or uncomplicated malaria. The respect of national recommendations is not systematic. Some factors interfere in their non-respect: physicians' experience, existence of other hospital therapeutic protocols, pharmacoeconomic considerations, therapeutic antecedents, hospital availability of malaria drugs.
Abrogoua
Danho Pascal
DP
Laboratoire de Pharmacie Clinique, Pharmacologie, Thérapeutique et Physiologie, UFR Sciences Pharmaceutiques et Biologiques, Université Cocody-Abidjan, BP 1397, Abidjan22, Côte d'Ivoire. abrogouadp@yahoo.fr
Kablan
Brou Jérôme
BJ
Ahipo
Babo Gilles
BG
D000655:Amodiaquine / Q000627:therapeutic use; D000962:Antimalarials / Q000627:therapeutic use*; D037621:Artemisinins / Q000627:therapeutic use*; D002648:Child; D002673:Child, Hospitalized; D007560:Cote d'Ivoire; D011307:Drug Prescriptions / Q000706:statistics & numerical data; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D008288:Malaria / Q000188:drug therapy*; D008499:Medical Records; D012189:Retrospective Studies
D000962:Antimalarials; D037621:Artemisinins; D000655:Amodiaquine; C031327:artemisinin