PET evidence of central GABAergic changes in stiff-person syndrome.
We measured expression of central nervous system GABA-A receptors with (11)C-flumazenil ((11)C-FMZ) and PET in two subjects with stiff person syndrome (SPS). We found reduced (11)C-FMZ binding potential (BP) in motor-premotor cortex, and increased (11)C-FMZ BP in the cerebellar nuclei. This is the first in vivo PET evidence of central GABA-A receptors dysfunction in SPS, possibly concurring to the motor symptoms.
Perani
Daniela
D
Istituto Nazionale di Neuroscienze, Vita-Salute San Raffaele University, Milan, Italy. daniela.perani@hsr.it
Garibotto
Valentina
V
Panzacchi
Andrea
A
Moresco
Rosa Maria
RM
Ortelli
Paola
P
Corbo
Massimo
M
Fazio
Ferruccio
F
Folli
Franco
F
D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D049268:Positron-Emission Tomography; D016750:Stiff-Person Syndrome / Q000000981:diagnostic imaging* / Q000378:metabolism* / Q000503:physiopathology; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D005680:gamma-Aminobutyric Acid