title: Proteomics analyses of ovarian cancer using genetically defined human ovarian cancer models.
abstract: Using a genetically defined human ovarian cancer model, we have analyzed the protein expression profile of human ovarian cancer cells established by oncogenic RAS transformation. Cells were immortalized by retroviral transfection of SV40 t/T antigens and the catalytic subunit of telomerase (hTERT). Careful analyses of protein targets associated with oncogenic transformation have enabled us to identify several novel signaling pathways that play important roles in oncogenic transformation of human ovarian epithelial cells.
authors.affiliation: Department of Pharmacology and Toxicology, Sealy Center for Cancer Cell Biology, The University of Texas Medical Branch, Galveston, Texas 77555-1031, USA. xcheng@utmb.edu
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Cheng
authors.forename: Travis W
authors.initials: TW
authors.lastname: Young
authors.forename: Fang C
authors.initials: FC
authors.lastname: Mei
mesh_terms: D017209:Apoptosis / Q000502:physiology; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D056827:Endosomal Sorting Complexes Required for Transport; D005260:Female; D006801:Humans; D008954:Models, Biological; D010051:Ovarian Neoplasms / Q000235:genetics / Q000378:metabolism*; D040901:Proteomics; D015398:Signal Transduction; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism; D014407:Tumor Cells, Cultured; D015854:Up-Regulation; D018631:ras Proteins / Q000378:metabolism; D000099177:Tsg101 Protein
chemical_list: D004268:DNA-Binding Proteins; D056827:Endosomal Sorting Complexes Required for Transport; D014157:Transcription Factors; D018631:ras Proteins; D000099177:Tsg101 Protein