Finding Plk3.
Polo-like kinases (Plks) are a highly conserved family of kinases found in flies, yeast and vertebrates. Plks derive their name from homology to the gene product of polo, a protein kinase first identified in Drosophila. Three polo-like kinases have been identified in vertebrates: Plk1, Plk2 and Plk3. Studies on Plk1 have revealed a great deal of information on its multiple functions, however Plk2 and Plk3 functions have not been fully explored. In this perspective we discuss recent work on Plk3 expression, function and localization in the context of previous reports on Plk3 and in terms of its relationship to Plk1.
Zimmerman
Wendy C
WC
Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts, USA.
Erikson
Raymond L
RL
D000818:Animals; D002453:Cell Cycle / Q000502:physiology*; D018797:Cell Cycle Proteins / Q000235:genetics / Q000502:physiology; D002460:Cell Line; D002466:Cell Nucleolus / Q000201:enzymology*; D019927:Cyclin E / Q000378:metabolism; D004790:Enzyme Induction; D016193:G1 Phase / Q000502:physiology; D017781:Genes, Immediate-Early; D006801:Humans; D008322:Mammals / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D017346:Protein Serine-Threonine Kinases / Q000172:deficiency / Q000235:genetics / Q000302:isolation & purification / Q000502:physiology*; D017434:Protein Structure, Tertiary; D011518:Proto-Oncogene Proteins / Q000235:genetics / Q000502:physiology; D016196:S Phase / Q000502:physiology; D013379:Substrate Specificity; D025521:Tumor Suppressor Proteins; D014714:Vertebrates / Q000378:metabolism*; D000097869:Polo-Like Kinase 1; D000097868:Polo-like Kinases
D018797:Cell Cycle Proteins; D019927:Cyclin E; D017346:Protein Serine-Threonine Kinases; D011518:Proto-Oncogene Proteins; D025521:Tumor Suppressor Proteins; D000097869:Polo-Like Kinase 1; C486256:PLK3 protein, human; D000097868:Polo-like Kinases; C093328:Plk3 protein, mouse