One-pot amidation of olefins through Pd-catalyzed coupling of alkylboranes and carbamoyl chlorides.
A one-pot synthesis of C1-elongated amides starting from olefins and carbamoyl chlorides has been developed. Alkylboranes, generated by hydroboration of terminal olefins with 9-BBN-H, underwent smooth coupling with carbamoyl chlorides in the presence of palladium catalyst and Cs2CO3.
Yasui
Yoshizumi
Y
Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan.
Tsuchida
Sayo
S
Miyabe
Hideto
H
Takemoto
Yoshiji
Y
D000475:Alkenes / Q000737:chemistry*; D000577:Amides / Q000737:chemistry*; D001880:Boranes / Q000737:chemistry*; D002384:Catalysis; D002712:Chlorides / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*
D000475:Alkenes; D000577:Amides; D001880:Boranes; D002712:Chlorides; D010165:Palladium