title: Synthesis, cytotoxicity, and antiviral activities of new neolignans related to honokiol and magnolol.
abstract: A series of new bisphenol derivatives bearing allylic moieties were synthesized as potential analogs of honokiol and/or magnolol. Certain compounds exhibited specific anti-proliferation activity against SVR cells and moderate anti-HIV-1 activity in primary human lymphocytes. Compound 5h was the most potent compound and its anti-tumor activity was evaluated in vivo.
authors.affiliation: Department of Pediatrics and Dermatology, Emory University School of Medicine, Atlanta, GA 30322, USA.
authors.forename: Franck
authors.initials: F
authors.lastname: Amblard
authors.forename: Baskaran
authors.initials: B
authors.lastname: Govindarajan
authors.forename: Benjamin
authors.initials: B
authors.lastname: Lefkove
authors.forename: Kimberly L
authors.initials: KL
authors.lastname: Rapp
authors.forename: Mervi
authors.initials: M
authors.lastname: Detorio
authors.forename: Jack L
authors.initials: JL
authors.lastname: Arbiser
authors.forename: Raymond F
authors.initials: RF
authors.lastname: Schinazi
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000737:chemistry* / Q000494:pharmacology; D015497:HIV-1 / Q000187:drug effects; D017705:Lignans / Q000737:chemistry* / Q000494:pharmacology; D015394:Molecular Structure; D000498:Allyl Compounds; D010636:Phenols
chemical_list: D000970:Antineoplastic Agents; D000998:Antiviral Agents; D001713:Biphenyl Compounds; D017705:Lignans; C005498:magnolol; C005499:honokiol; D000498:Allyl Compounds; D010636:Phenols