Association between AMPD1 gene polymorphism and coagulation factors in patients with coronary heart disease.
The aim of this study was to investigate whether the C34T and G468T variations in the adenosine monophosphate deaminase-1 (AMPD1) gene were associated with intima-media thickness of the carotid and brachial artery, endothelial function of the brachial artery, glucose metabolism, haemostatic variables and cardiac hypertrophy in patients (n = 109) with coronary heart disease. The plasminogen activator inhibitor-1 activity and the von Willebrand factor were higher in the CC homozygote group compared to the CT/TT group (p < 0.05). There were no differences between the groups regarding intima-media complex of the carotid and brachial artery, presence of plaque in the carotid region, flow-mediated dilatation, ejection fraction or dimensions of the heart. In conclusion, there were no differences between the mutant AMPD1 allele carriers and CC homozygotes regarding surrogate values for atherosclerosis, endothelial function, dimensions and ejection fraction of the heart, glucose tolerance and other well-known cardiovascular risk factors, whereas plasminogen activator inhibitor-1 activity and von Willebrand levels were lower in the mutant AMPD1 allele carriers.
Agewall
S
S
Department of Cardiology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden. stefan.agewall@medisin.uio.no
Norman
B
B
D000659:AMP Deaminase / Q000235:genetics* / Q000378:metabolism; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D019943:Amino Acid Substitution; D006332:Cardiomegaly; D002339:Carotid Arteries / Q000378:metabolism / Q000473:pathology; D003324:Coronary Artery Disease / Q000097:blood* / Q000235:genetics*; D005260:Female; D005947:Glucose / Q000378:metabolism; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D008297:Male; D008875:Middle Aged; D020125:Mutation, Missense; D017395:Plasminogen Activator Inhibitor 1 / Q000032:analysis* / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D017539:Tunica Intima / Q000378:metabolism / Q000473:pathology; D014841:von Willebrand Factor / Q000032:analysis* / Q000235:genetics
D017395:Plasminogen Activator Inhibitor 1; D014841:von Willebrand Factor; D000659:AMP Deaminase; C514117:AMPD1 protein, human; D005947:Glucose