title: Intra-abdominal splenosis following laparoscopic splenectomy causing recurrence in a child with chronic immune thrombocytopenic purpura.
abstract: In this paper, we present the case of a 12-year-old boy with refractory, symptomatic immune thrombocytopenic purpura (ITP) who underwent a laparoscopic splenectomy (LS). During morcellation of the spleen the retrieval bag ruptured. Thirteen (13) months postoperatively, the patient developed further symptoms and was found to be thrombocytopenic. Tc-99m heat-damaged red blood cell scintigraphy showed an accumulation of heat-damaged red cells in the upper left quadrant, raising the possibility of missed accessory spleen. Laparoscopic exploration revealed widespread intra-abdominal splenosis, and a therapeutic omentectomy was carried out. Fourteen (14) months post-surgery, platelet counts improved and the patient remains well. Following an elective splenectomy, a relapse in ITP may be the result of missed accessory spleen or splenosis; in others, it may the result of ongoing platelet consumption in non-splenic, reticulo-endothelial tissue. During LS, consideration must therefore be given to the risk of not only leaving additional splenic tissue behind, but also to the possibility of accidental autotransplantation, such as that from laparoscopic bag rupture. The risk of rupture can be minimized by using blunt instruments and stronger bag materials. If a rupture does occur, immediate suction and a thorough search for splenic fragments must be undertaken. Further development is needed into new techniques for organ retrieval and stronger bag materials.
authors.affiliation: Paediatric Surgical Unit, Sheffield Children's Hospital, Sheffield, United Kingdom.
authors.forename: Nick
authors.initials: N
authors.lastname: Lansdale
authors.forename: Sean
authors.initials: S
authors.lastname: Marven
authors.forename: Jenny
authors.initials: J
authors.lastname: Welch
authors.forename: Ajay
authors.initials: A
authors.lastname: Vora
authors.forename: Alan
authors.initials: A
authors.lastname: Sprigg
mesh_terms: D002648:Child; D017558:Elective Surgical Procedures / Q000009:adverse effects; D004912:Erythrocytes; D005500:Follow-Up Studies; D006801:Humans; D010535:Laparoscopy / Q000009:adverse effects*; D008297:Male; D009852:Omentum / Q000601:surgery; D015609:Organotechnetium Compounds; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000209:etiology*; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D012008:Recurrence; D013156:Splenectomy / Q000009:adverse effects*; D017890:Splenosis / Q000150:complications* / Q000000981:diagnostic imaging / Q000601:surgery
chemical_list: D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals