Mitosis: springtime for chromatin.
When a eukaryotic cell divides, tension builds at centromeres as spindle forces pull chromosomes toward opposite poles during metaphase. New data show that centromeric chromatin stretches in response to these forces, revealing a mechanical role for chromatin packaging in mitosis.
Myers
Lawrence C
LC
Department of Biochemistry and Norris Cotton Cancer Center, Dartmouth Medical School, Hanover, New Hampshire 03755, USA. Lawrence.c.myers@dartmouth.edu
Compton
Duane A
DA
D000705:Anaphase / Q000235:genetics / Q000502:physiology; D000818:Animals; D002455:Cell Division; D002503:Centromere; D002843:Chromatin / Q000235:genetics / Q000378:metabolism*; D042002:Chromatin Assembly and Disassembly; D005057:Eukaryotic Cells / Q000166:cytology*; D005786:Gene Expression Regulation; D006801:Humans; D008677:Metaphase / Q000235:genetics / Q000502:physiology; D015398:Signal Transduction; D008941:Spindle Apparatus / Q000378:metabolism*
D002843:Chromatin