title: [A case of advanced colon cancer invading the rectum effectively treated with chemoradiation therapy before surgery].
abstract: A 56-year-old man was hospitalized for anemia with appetite loss and body weight loss. He was diagnosed as advanced sigmoid colon cancer which invaded the rectal colon (Ra) and prostate (SI, N 0, P 0, H 0, M (-), cStage IIIa). We administered neoadjuvant chemoradiotherapy for fear of non-curative resection of the sigmoid colon and rectum after colostomy was performed. He was given radiation of the whole pelvis at a total dose of 39 .6 Gy (1.8 Gy x 22 times) combined with chemotherapy using continuous intravenous 5-FU (500 mg x 22 times). Two weeks after the chemoradiation, we administered chemotherapy (FOLFOX 4). Resectable resection was confirmed on Computed Tomography. We were able to conduct a low anterior resection of sigmoid colon and rectum. Postoperative histopathological examination of the resected sigmoid colon and rectum revealed no remnant cancer tissue. Neo-adjuvant chemoradiotherapy is considered to be effective for a study of non-curative resection of rectum.
authors.affiliation: Dept. of Surgery, Showa University Fujigaoka Hospital.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Mizukami
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Yoshizawa
authors.forename: Shoji
authors.initials: S
authors.lastname: Sasaya
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nemoto
authors.forename: Koji
authors.initials: K
authors.lastname: Maezawa
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Sanada
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D004334:Drug Administration Schedule; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D002955:Leucovorin / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009944:Organoplatinum Compounds / Q000008:administration & dosage; D011471:Prostatic Neoplasms / Q000473:pathology*; D018714:Radiotherapy, Adjuvant; D012004:Rectal Neoplasms / Q000473:pathology*; D012811:Sigmoid Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery
chemical_list: D009944:Organoplatinum Compounds; D002955:Leucovorin; D005472:Fluorouracil