Inhibition of selenium dependent glutathione peroxidase and superoxide dismutase in rats by diethyldithiocarbamate: effect of pre-administration of alpha-tocopherol.
Rats pre-administered with alpha-tocopherol (10 mgs/day) for 7 days afforded a significant protection at the tissue level against the lowering of superoxide dismutase and glutathione peroxidase, especially the selenium-dependent glutathione peroxidase. The protective action of alpha-tocopherol in the diethyldithiocarbamate treated rats may be attributed to its antioxidant/free radical scavenging action. It is concluded that selenium-dependent glutathione peroxidase and alpha-tocopherol act in a complementary fashion to block free radical formation.
Prabhu
H Ramachandra
HR
Department of Biochemistry, Kasturba Medical College, Mangalore 575 001, India. hergaprabhu@rediffmail.com
Nandini
M
M
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D019610:Cytoprotection / Q000187:drug effects; D004050:Ditiocarb / Q000633:toxicity*; D005609:Free Radicals / Q000032:analysis; D005979:Glutathione Peroxidase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008297:Male; D000080662:Phospholipid Hydroperoxide Glutathione Peroxidase; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D013997:Time Factors; D024502:alpha-Tocopherol / Q000494:pharmacology*
D000975:Antioxidants; D005609:Free Radicals; D004050:Ditiocarb; D000080662:Phospholipid Hydroperoxide Glutathione Peroxidase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D024502:alpha-Tocopherol