IA in play.
Everyone agrees about how long-term potentiation (LTP) is induced-NMDA receptor activation-but much remains to be learned about how the increase in the strength of a synaptic connection between two neurons is expressed. In this issue of Neuron, Kim et al. report a new form of NMDAR-dependent plasticity that may contribute to LTP: internalization of postsynaptic Kv4.2 potassium channels that mediate transient IA-type outward current in dendrites.
Thompson
Scott M
SM
Department of Physiology, University of Maryland School of Medicine, 655 West Baltimore Street, Baltimore, MD 21201, USA. sthom003@umaryland.edu
D000818:Animals; D003712:Dendrites / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology*; D016194:Receptors, N-Methyl-D-Aspartate / Q000502:physiology; D051672:Shal Potassium Channels / Q000502:physiology*
D016194:Receptors, N-Methyl-D-Aspartate; D051672:Shal Potassium Channels