title: Increasing ceftriaxone resistance and multiple alterations of penicillin-binding proteins among penicillin-resistant Streptococcus pneumoniae isolates in Taiwan.
abstract: The rate of nonsusceptibility of penicillin-resistant Streptococcus pneumoniae strains to ceftriaxone increased significantly in Taiwan in 2005. Approximately 90% of the ceftriaxone-nonsusceptible isolates were found to be of four major serotypes (serotypes 6B, 14, 19F, and 23F). Seven amino acid alterations in the penicillin-binding protein 2B transpeptidase-encoding region specifically contributed to the resistance.
authors.affiliation: Department of Pediatrics, Chang Gung Children's Hospital, 5 Fu-Hsin Street, Kweishan 333, Taoyuan, Taiwan. chchiu@adm.cgmh.org.tw
authors.forename: Cheng-Hsun
authors.initials: CH
authors.lastname: Chiu
authors.forename: Lin-Hui
authors.initials: LH
authors.lastname: Su
authors.forename: Yhu-Chering
authors.initials: YC
authors.lastname: Huang
authors.forename: Jui-Chia
authors.initials: JC
authors.lastname: Lai
authors.forename: Hsiu-Ling
authors.initials: HL
authors.lastname: Chen
authors.forename: Tsu-Lan
authors.initials: TL
authors.lastname: Wu
authors.forename: Tzou-Yien
authors.initials: TY
authors.lastname: Lin
mesh_terms: D019943:Amino Acid Substitution; D019881:Aminoacyltransferases / Q000378:metabolism; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002443:Ceftriaxone / Q000494:pharmacology*; D017931:DNA Primers; D024881:Drug Resistance, Bacterial; D016521:Electrophoresis, Gel, Pulsed-Field; D006801:Humans; D010403:Penicillin Resistance / Q000235:genetics*; D046915:Penicillin-Binding Proteins / Q000235:genetics* / Q000378:metabolism; D011008:Pneumococcal Infections / Q000453:epidemiology / Q000382:microbiology*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013296:Streptococcus pneumoniae / Q000187:drug effects* / Q000235:genetics*; D013624:Taiwan / Q000453:epidemiology
chemical_list: D000900:Anti-Bacterial Agents; D017931:DNA Primers; D046915:Penicillin-Binding Proteins; D002443:Ceftriaxone; D019881:Aminoacyltransferases; C478701:penicillin-binding protein 2b, Streptococcus