Surface-seeking radionuclides in the skeleton: current approach and recent developments in biokinetic modelling for humans and beagles.
In the last decade, the biokinetics of surface-seeking radionuclides in the skeleton has been the object of several studies. Investigations were carried out to determine the kinetics of plutonium and americium in the skeleton of humans and beagles. As a result of these investigations, in recent years the models presented by ICRP in Publication 67 for humans were partially revised, particularly the skeletal part. The aim of the present work is to present recent developments in the biokinetic modelling of surface-seeking radionuclides (plutonium and americium) in beagles and humans. Various assumptions and physiological interpretations of the different approaches to the biokinetic modelling of the skeleton are discussed. Current ICRP concepts and skeleton modelling of plutonium and americium in humans are compared to the latest developments in biokinetic modelling in beagles.
Luciani
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ENEA, Radiation Protection Institute, via dei Colli N 16, 40136 Bologna, Italy. luciani@bologna.enea.it
Polig
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E
D000818:Animals; D001681:Biological Assay / Q000379:methods*; D001842:Bone and Bones / Q000378:metabolism*; D003198:Computer Simulation; D004285:Dogs; D006801:Humans; D008954:Models, Biological; D011829:Radiation Dosage; D011868:Radioisotopes / Q000493:pharmacokinetics*; D011874:Radiometry / Q000379:methods* / Q000639:trends*; D012062:Relative Biological Effectiveness; D012680:Sensitivity and Specificity; D013045:Species Specificity
D011868:Radioisotopes