title: Reactions between Weinreb amides and 2-magnesiated oxazoles: a simple and efficient preparation of 2-acyl oxazoles.
abstract: Treatment of oxazole or 5-aryl oxazoles with i-PrMgCl smoothly generates the corresponding 2-Grignard reagents, which react with Weinreb amides to provide exclusively 2-acyl oxazole products.
authors.affiliation: Johnson & Johnson Pharmaceutical Research and Development, L.L.C., 3210 Merryfield Row, San Diego, CA 92121, USA. dpippel@prdus.jnj.com
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Pippel
authors.forename: Christopher M
authors.initials: CM
authors.lastname: Mapes
authors.forename: Neelakandha S
authors.initials: NS
authors.lastname: Mani
mesh_terms: D000577:Amides / Q000737:chemistry*; D008274:Magnesium / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D010080:Oxazoles / Q000737:chemistry*
chemical_list: D000577:Amides; D010080:Oxazoles; D008274:Magnesium