Trisomy 19 is associated with trisomy 12 and mutated IGHV genes in B-chronic lymphocytic leukaemia.
The occurrence of trisomy 19 was investigated in 705 cases of B-chronic lymphocytic leukaemia (CLL) by metaphase cytogenetic and/or fluorescence in situ hybridisation analyses. Trisomy 19 was detected in 11 cases (1.6%), all of which also carried a trisomy 12; nine of 10 had mutated IGHV genes. In contrast, B-CLL cases with trisomy 12 lacking trisomy 19 mostly had unmutated IGHV genes. Karyotypes of the present study and the literature identified a strong correlation to trisomy 18 in addition to trisomy 12. Trisomy 19 seems to be a secondary event in B-CLL with trisomy 12, mostly originating from mutated B cells.
Sellmann
Ludger
L
Department of Haematology, Medical Faculty, University of Duisburg-Essen, Essen, Germany. ludger.sellmann@uk-essen.de
Gesk
Stefan
S
Walter
Christoph
C
Ritgen
Matthias
M
Harder
Lana
L
Martín-Subero
José I
JI
Schroers
Roland
R
Siemer
Dörte
D
Nückel
Holger
H
Dyer
Martin J S
MJ
Dührsen
Ulrich
U
Siebert
Reiner
R
Dürig
Jan
J
Küppers
Ralf
R
D002881:Chromosomes, Human, Pair 12 / Q000235:genetics; D002888:Chromosomes, Human, Pair 19 / Q000235:genetics; D016000:Cluster Analysis; D005260:Female; D052138:Genes, Neoplasm / Q000235:genetics; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics*; D007135:Immunoglobulin Variable Region / Q000235:genetics*; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009154:Mutation; D014314:Trisomy / Q000235:genetics*
D007143:Immunoglobulin Heavy Chains; D007135:Immunoglobulin Variable Region