Spray-dried microspheres based on methylpyrrolidinone chitosan as new carrier for nasal administration of metoclopramide.
The work purpose was to study the application of 5-methylpyrrolidinone chitosan (MPC) for preparing mucoadhesive microparticles for the nasal administration of drugs. Microspheres were produced by the spray-drying technique using MPC; metoclopramide hydrochloride (MC) was chosen as model drug. Chitosan microparticles were prepared as a comparison. The microparticles obtained were characterised (encapsulation efficiency, morphology, size and drug release behaviour). In-vitro mucoadhesive tests, swelling tests and ex-vivo studies using sheep nasal mucosa were performed. The hydrogel formation from microspheres was studied in different media and at different pHs. Microspheres are able to control the in-vitro MC release. MPC microparticles show good in-vitro mucoadhesive properties and ex-vivo controlled permeation profiles. The hydrogel formation is dependent mainly on the medium used: ionically crosslinked hydrogel was hypothesized. These in-vitro and ex-vivo preliminary results show that spray-dried microspheres based on MPC could be a suitable nasal delivery system for the administration of metoclopramide.
Gavini
Elisabetta
E
Department of Drug Sciences, University of Sassari, Sassari, Italy.
Rassu
Giovanna
G
Muzzarelli
Corrado
C
Cossu
Massimo
M
Giunchedi
Paolo
P
D000281:Administration, Intranasal; D000818:Animals; D000932:Antiemetics / Q000008:administration & dosage*; D048271:Chitosan / Q000737:chemistry*; D004337:Drug Carriers; D020100:Hydrogels; D008787:Metoclopramide / Q000008:administration & dosage*; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D011760:Pyrrolidinones / Q000737:chemistry*; D012756:Sheep
D000932:Antiemetics; D004337:Drug Carriers; D020100:Hydrogels; D011760:Pyrrolidinones; C085060:methylpyrrolidinone chitosan; D048271:Chitosan; D008787:Metoclopramide