New cycloartane-type triterpene arabinosides from the roots of Actaea podocarpa and their biological study.
Three new cycloartane-type triterpene arabinosides, podocarpasides H - J (1 - 3) were isolated from the roots of Actaea podocarpa (Ranunculaceae). Their structures were determined by spectroscopic and chemical methods. The isolates were tested for cytotoxic, estrogenic, antioxidant, and anticomplement activities. They were found inactive in the tested assays, except for podocarpaside I (2), which showed moderate anticomplement activity with an IC(50) value of 250 microM.
Ali
Zulfiqar
Z
National Center for Natural Products Research, University of Mississippi, University, MS 38677, USA.
Khan
Shabana I
SI
Khan
Ikhlas A
IA
D031842:Actaea; D051056:Complement Inactivating Agents / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D003165:Complement System Proteins / Q000187:drug effects; D006801:Humans; D020128:Inhibitory Concentration 50; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D018517:Plant Roots; D014315:Triterpenes / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use
D051056:Complement Inactivating Agents; D010936:Plant Extracts; D014315:Triterpenes; C085352:cycloartane; D003165:Complement System Proteins