The cholesteryl ester transfer protein I405V polymorphism is associated with increased high-density lipoprotein levels and decreased risk of myocardial infarction: the Rotterdam Study.
METHODS
The effect of the cholesteryl ester transfer protein (CETP) I405V polymorphism on lipid levels, atherosclerosis and myocardial infarction (MI) was examined in 6421 participants from the Rotterdam Study.


METHODS
Quantitative outcomes were studied with linear models; Cox models were used to assess MI risk.


RESULTS
High-density lipoprotein cholesterol (HDL) increased by 0.06 [95% confidence interval (CI): 0.03, 0.09] mmol/l in VV carriers. The V allele was further associated with decreased MI risk in men [hazard ratio (95% confidence interval)=0.57 (0.45, 0.73), VV versus II] (Ptrend=0.02).


CONCLUSIONS
This study provides additional evidence for the association of CETP with HDL levels and suggests that CETP is an atherogenic protein increasing the risk of MI.
Isaacs
Aaron
A
Genetic Epidemiology Unit, Erasmus Medical Center, Rotterdam, The Netherlands.
Sayed-Tabatabaei
Fakhredin A
FA
Hofman
Albert
A
Oostra
Ben A
BA
Klungel
Olaf H
OH
Maitland-Vander Zee
Anke-Hilse
AH
Stricker
Bruno H Ch
BH
Witteman
Jacqueline C M
JC
van Duijn
Cornelia M
CM
D050197:Atherosclerosis / Q000097:blood / Q000150:complications / Q000235:genetics; D053480:Cholesterol Ester Transfer Proteins / Q000235:genetics*; D005260:Female; D005500:Follow-Up Studies; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D015994:Incidence; D016014:Linear Models; D008075:Lipoproteins, HDL / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000453:epidemiology / Q000235:genetics*; D009426:Netherlands / Q000453:epidemiology; D011110:Polymorphism, Genetic; D011159:Population Surveillance; D016016:Proportional Hazards Models; D011446:Prospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D012737:Sex Factors; D013997:Time Factors; D015854:Up-Regulation
D053480:Cholesterol Ester Transfer Proteins; D008075:Lipoproteins, HDL