Role of interventional therapy in hepatic artery stenosis and non-anastomosis bile duct stricture after orthotopic liver transplantation.
OBJECTIVE
To analyze the clinical manifestations and the effectiveness of therapy in patients with orthotopic liver transplantation (OLT)-associated hepatic artery stenosis (HAS) and non-anastomosis bile duct stricture.


METHODS
Nine cases were diagnosed as HAS and non-anastomosis bile duct stricture. Percutaneous transluminal angioplasty (PTA) was performed in four HAS cases, and expectant treatment in other five HAS cases; percutaneous transhepatic bile drainage, balloon dilation, stent placement were performed in all nine cases.


RESULTS
Diffuse intra- and extra-bile duct stricture was observed in nine cases, which was associated with bile mud siltation and biliary infection. Obstruction of the bile duct was improved obviously or removed. Life span/follow-up period was 13-30 mo after PTA of four HAS cases, 6-23 mo without PTA of other five cases.


CONCLUSIONS
Progressive, non-anastomosis, and diffuse bile duct stricture are the characteristic manifestations of HAS and non-anastomosis bile duct stricture after OLT. These are often associated with bile mud siltation, biliary infection, and ultimate liver failure. Interventional therapy is significantly beneficial.
Zhao
Da-Bing
DB
The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, Guangdong Province, China.
Shan
Hong
H
Jiang
Zai-Bo
ZB
Huang
Ming-Sheng
MS
Zhu
Kang-Shun
KS
Chen
Gui-Hua
GH
Meng
Xiao-Chun
XC
Guan
Shou-Hai
SH
Li
Zheng-Ran
ZR
Qian
Jie-Sheng
JS
D000328:Adult; D000368:Aged; D000800:Angioplasty, Balloon / Q000379:methods; D002404:Catheterization / Q000379:methods; D002779:Cholestasis / Q000209:etiology / Q000601:surgery* / Q000628:therapy*; D003251:Constriction, Pathologic / Q000150:complications / Q000209:etiology; D005260:Female; D006499:Hepatic Artery / Q000601:surgery*; D006801:Humans; D016031:Liver Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D015427:Reperfusion Injury / Q000150:complications / Q000209:etiology; D012189:Retrospective Studies; D015607:Stents