[Effects of phytoestrogens on prostate cancer and benign prostatic hyperplasia].
Phytoestrogens are non-steroidal estrogens widely distributed in many kinds of plants. They are natural compounds structurally similar to estrogen and with estrogenic or anti-androgenic activities. Prostate cancer (PCa) and benign prostatic hyperplasia (BPH) are androgen-dependent and associated with age. Recently, in many epidemiological and experimental researches, it has been reported that phytoestrogens play a role in the prevention and treatment of PCa and BPH. Regulation of sexual hormones, inhibition of cell proliferation, induction of cell apoptosis and anti-oxidation of such plant estrogens may be involved in the mechanisms.
Feng
Yao
Y
PLA Research Institute of Clinical Laboratory Medicine, Nanjing General Hospital of Nanjing Command, PLA, Nanjing, 21002 Jiangsu, China.
Xia
Xin-yi
XY
Huang
Yu-feng
YF
D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D008297:Male; D048789:Phytoestrogens / Q000494:pharmacology*; D011470:Prostatic Hyperplasia / Q000473:pathology / Q000517:prevention & control*; D011471:Prostatic Neoplasms / Q000473:pathology / Q000517:prevention & control*; D051381:Rats; D017207:Rats, Sprague-Dawley; D017208:Rats, Wistar
D048789:Phytoestrogens