Identification of immunogenic MHC class II Tyrosinase-derived peptides using HLA-DR1 and HLA-DR4 transgenic mice.
The immunogenicity of "novel" MART-1 and Tyrosinase class-II peptides was assessed in transgenic mice. Tyrosinase(141-161) peptide was found to be immunogenic and endogenously processed in the HLA-DRbeta1*0101 and HLA-DRbeta1*0401 transgenic mice with peptide specific production of IFNgamma or IL-5 respectively. The MART-1(29-43) peptide was only found immunogenic in HLA-DRbeta1*0101 mice.
Horton
R B V
RB
The School of Biomedical and Natural Science, Nottingham Trent University, Clifton Campus, Interdisciplinary Biomedical Research Centre, Clifton Lane, Clifton, Nottingham, NG11 8NS, UK.
Laversin
S A S
SA
Reeder
S P
SP
Rees
R C
RC
McArdle
S E B
SE
D000818:Animals; D002478:Cells, Cultured; D006098:Granulocytes; D006680:HLA Antigens / Q000276:immunology*; D015798:HLA-DR1 Antigen / Q000276:immunology; D015804:HLA-DR4 Antigen / Q000276:immunology; D007519:Isoantigens / Q000302:isolation & purification*; D008545:Melanoma / Q000276:immunology; D051379:Mice; D008822:Mice, Transgenic; D014442:Monophenol Monooxygenase / Q000276:immunology / Q000378:metabolism*; D010446:Peptide Fragments / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D006680:HLA Antigens; D015798:HLA-DR1 Antigen; D015804:HLA-DR4 Antigen; C531098:HNA-4A antigen; D007519:Isoantigens; D010446:Peptide Fragments; D014442:Monophenol Monooxygenase