Multi-centered clinical study on effects of nano-amomi paste in treating children's anorexia.
OBJECTIVE
To assess the effect and safety of nano-Amoni Paste (nmAP) in the treatment of children's anorexia (AR).


METHODS
One hundred and eighty patients of AR were assigned according to the randomized, double-blinded, double-simulated and parallel controlled principle to three groups, the treated group (TG), the positive control group (PCG) and the negative control group (NCG), 60 in each group. The patients in TG were treated by sticking 1.5 ml of nmAP on the acupoint of Shenque (Ren 8) once a day and orally taking placebo liquid 10 ml twice a day; those in PCG and NCG treated with sticking paste of placebo on Ren 8, and oral taking of Shanmai Jianpi Oral Liquid and placebo liquid respectively, 10 ml each time twice per day. The course of treatment for all was 10 days, all patients were treated for 2 courses.


RESULTS
The total effective rate and the effective rate on cardinal symptom in TG was 85.0% and 95.0% respectively, that in PCG 86.2% and 96.55% and in NCG 45.5% and 65.45%, respectively, showing significant difference between groups (P<0.05). Comparison of the clinical manifestation before and after treatment showed significant improvement in volume of food intake, appetite, complexion and reduction of restlessness symptom (P<0.05) in all three groups, and there was no adverse reaction found in them.


CONCLUSIONS
nmAP is an effective and safe remedy for treatment of Children's anorexia.
Wu
Min
M
Department of Traditional Chinese Medicine, Affiliated Xinhua Hospital of Medical College of Shanghai Jiaotong University, Shanghai 200092. minwu@eastday.com
Li
Zhan
Z
Yu
Jian-Er
JE
Lu
Wei-wei
WW
Ni
Ju-xiu
JX
Xia
Yi-lin
YL
D015669:Acupuncture Points; D035801:Amomum / Q000737:chemistry*; D000855:Anorexia / Q000503:physiopathology / Q000628:therapy*; D001066:Appetite / Q000187:drug effects; D001827:Body Height / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D002648:Child; D002675:Child, Preschool; D004311:Double-Blind Method; D004435:Eating / Q000187:drug effects; D005260:Female; D006801:Humans; D008081:Liposomes; D008297:Male; D053758:Nanoparticles; D009822:Oils, Volatile / Q000008:administration & dosage* / Q000009:adverse effects / Q000302:isolation & purification / Q000627:therapeutic use; D009824:Ointments; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D011595:Psychomotor Agitation / Q000503:physiopathology; D016896:Treatment Outcome
D008081:Liposomes; D009822:Oils, Volatile; D009824:Ointments; D010936:Plant Extracts