Cellular mechanisms of brain hypoglycemia.
Data on intracellular processes induced by a low glucose level in nerve tissue are presented. The involvement of glutamate and adenosine receptors, mitochondria, reactive oxygen species (ROS), and calcium ions in the development of hypoglycemia-induced damage of neurons is considered. Hypoglycemia-induced calcium overload of neuronal mitochondria is suggested to be responsible for the increased ROS production by mitochondria.
Isaev
N K
NK
Belozersky Institute of Physico-Nhemical Biology, Lomonosov Moscow State University, Moscow 119992, Russia. isaev@genebee.msu.su
Stel'mashuk
E V
EV
Zorov
D B
DB
D000818:Animals; D001921:Brain / Q000378:metabolism* / Q000473:pathology; D002118:Calcium / Q000378:metabolism; D005971:Glutamates / Q000378:metabolism; D006801:Humans; D007003:Hypoglycemia / Q000378:metabolism* / Q000503:physiopathology; D008928:Mitochondria / Q000378:metabolism; D008954:Models, Biological; D009474:Neurons / Q000378:metabolism* / Q000473:pathology; D017382:Reactive Oxygen Species / Q000378:metabolism
D005971:Glutamates; D017382:Reactive Oxygen Species; D002118:Calcium