[Positron emission tomography with L-[S-methyl-11C]-methioine and its biodistribution].
OBJECTIVE
To study the biodistribution of L-[S-methyl-(11)C]-methioine ((11)C-MET) and explore its clinical application in positron emission tomography (PET) for brain tumor detection.


METHODS
Twenty-four Wistar rats and divided into 6 equal groups and injected with (11)C-MET through the tail vein and killed by decollation at 5, 10, 20, 30 and 40 min after injection, respectively. The liver, brain, blood, heart, lung, kidney, and spleen were harvested to measure the radioactivity and calculate the biodistribution of (11)C-MET. PET imaging with (11)C-MET was performed in 6 normal volunteers and 30 patients with pathologically confirmed brain gliomas.


CONCLUSIONS
(11)C-MET showed high blood uptake and a long retention in the tumor mass, therefore can be a valuable tracer for PET imaging of brain tumor and the hypophysis.
Chen
Li-guang
LG
Department of Nuclear Medicine, Guangdong Provincial People's Hospital, Guangzhou 510080, China. liguang_chen@yahoo.com.cn
Zhou
Mei-juan
MJ
Tan
An-wu
AW
Wang
Shu-xia
SX
He
Shan-zhen
SZ
Ding
Zhen-hua
ZH
D000328:Adult; D000368:Aged; D000818:Animals; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology; D001932:Brain Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000378:metabolism; D002250:Carbon Radioisotopes; D005260:Female; D005910:Glioma / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000378:metabolism; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals / Q000008:administration & dosage / Q000493:pharmacokinetics; D051381:Rats; D017208:Rats, Wistar; D012680:Sensitivity and Specificity; D014018:Tissue Distribution; D014814:Vitamin U / Q000008:administration & dosage / Q000493:pharmacokinetics*
D002250:Carbon Radioisotopes; D019275:Radiopharmaceuticals; D014814:Vitamin U