title: Dissecting corollary discharge dysfunction in schizophrenia.
abstract: During talking, a corollary discharge prepares cortex for self-generated sounds, minimizing responsiveness and providing a way to recognize sounds as self-generated. When we talk, we are the agent producing the sound and know what sound to expect. The auditory ERP N1 is normally suppressed during talking, but less so in schizophrenia, perhaps due to deficits in agency and expectancy inherent to talking. N1 was assessed in 27 patients (23 schizophrenia, 4 schizoaffective) and 26 controls. During talking, subjects said "ah" every 1-2 s. During agency, subjects pressed a button to deliver "ah" every 1-2 s. During expectancy, "ah" followed a visual warning. Talking yielded greatest N1 suppression in controls and greatest suppression failure in patients. Agency and expectancy had modest suppression effects on N1 and only in controls. Group differences in expectancy and agency could not account for failed corollary discharge during talking in patients.
authors.affiliation: Psychiatry Service, Veterans Affairs Connecticut Healthcare System, West Haven 06517, and Department of Psychiatry, Yale University School of Medicne, New Haven, Connecticut, USA. Judith.ford@yale.edu
authors.forename: Judith M
authors.initials: JM
authors.lastname: Ford
authors.forename: Max
authors.initials: M
authors.lastname: Gray
authors.forename: William O
authors.initials: WO
authors.lastname: Faustman
authors.forename: Brian J
authors.initials: BJ
authors.lastname: Roach
authors.forename: Daniel H
authors.initials: DH
authors.lastname: Mathalon
mesh_terms: D000328:Adult; D001303:Auditory Cortex / Q000502:physiology; D002138:Calibration; D003627:Data Interpretation, Statistical; D004569:Electroencephalography; D005071:Evoked Potentials / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D010775:Photic Stimulation; D012559:Schizophrenia / Q000503:physiopathology*; D012565:Schizophrenic Psychology; D013060:Speech