A case of spontaneous regression of small cell lung cancer with progression of paraneoplastic sensory neuropathy.
We report here a rare case of small cell lung cancer (SCLC) accompanied by a partial spontaneous regression with a progression of paraneoplastic sensory neuropathy (PSN). A 55-year-old woman was admitted to our hospital with dry cough and progressive numbness in the distal extremities over 1 month. She was diagnosed as small cell lung cancer associated with paraneoplastic sensory neuropathy. About 1 month later, partial spontaneous regression of tumor with a progression of paraneoplastic sensory neuropathy was observed. A complete response was achieved through chemotherapy and concurrent radiotherapy. As the tumor size decreased, her neurological symptoms improved. A short interval between onset of PSN and the start of therapy may be essential for successful treatment for not only SCLC but also PSN.
Hirano
Satoshi
S
Department of Respiratory Medicine, International Medical Center of Japan, 1-21-1, Toyama, Shinjuku-ku, Tokyo 162-8655, Japan. shirano@imcj.hosp.go.jp
Nakajima
Yoshifumi
Y
Morino
Eriko
E
Fujikura
Yuji
Y
Mochizuki
Makoto
M
Takeda
Yuichiro
Y
Sugiyama
Haruhito
H
Kobayashi
Nobuyuki
N
Tanaka
Keiko
K
Kudo
Koichiro
K
D000818:Animals; D018288:Carcinoma, Small Cell / Q000150:complications* / Q000473:pathology; D018450:Disease Progression; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000150:complications* / Q000473:pathology; D008875:Middle Aged; D020364:Paraneoplastic Polyneuropathy / Q000150:complications*; D013902:Radiography, Thoracic; D051381:Rats; D012075:Remission, Spontaneous