Synthesis, cytotoxicity, and antiviral activities of new neolignans related to honokiol and magnolol.
A series of new bisphenol derivatives bearing allylic moieties were synthesized as potential analogs of honokiol and/or magnolol. Certain compounds exhibited specific anti-proliferation activity against SVR cells and moderate anti-HIV-1 activity in primary human lymphocytes. Compound 5h was the most potent compound and its anti-tumor activity was evaluated in vivo.
Amblard
Franck
F
Department of Pediatrics and Dermatology, Emory University School of Medicine, Atlanta, GA 30322, USA.
Govindarajan
Baskaran
B
Lefkove
Benjamin
B
Rapp
Kimberly L
KL
Detorio
Mervi
M
Arbiser
Jack L
JL
Schinazi
Raymond F
RF
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000737:chemistry* / Q000494:pharmacology; D015497:HIV-1 / Q000187:drug effects; D017705:Lignans / Q000737:chemistry* / Q000494:pharmacology; D015394:Molecular Structure; D000498:Allyl Compounds; D010636:Phenols
D000970:Antineoplastic Agents; D000998:Antiviral Agents; D001713:Biphenyl Compounds; D017705:Lignans; C005498:magnolol; C005499:honokiol; D000498:Allyl Compounds; D010636:Phenols