Antidiabetic activities of chalcones isolated from a Japanese Herb, Angelica keiskei.
Diabetes mellitus is a chronic disease that is characterized by hyperglycemia caused by insufficient insulin action. We have explored the edible ingredients from folk medicines in Japan that contain substances complementing insulin action, such as the induction of adipocyte differentiation and the enhancement of glucose uptake. We eventually found that the ethanol extract from a Japanese herb "Ashitaba", Angelica keiskei, contained two major chalcones of 4-hydroxyderricin (4-HD) and xanthoangelol that showed strong insulin-like activities via a pathway independent of the peroxisome proliferator-activated receptor-gamma activation. The 4-HD especially showed the preventive effects on the progression of diabetes in genetically diabetic KK-Ay mice.
Enoki
Tatsuji
T
Biotechnology Research Laboratories, Takara Bio Inc., 3-4-1 Seta, Otsu, Shiga, 520-2193, Japan. enokit@takara-bio.co.jp
Ohnogi
Hiromu
H
Nagamine
Kinuko
K
Kudo
Yoko
Y
Sugiyama
Katsumi
K
Tanabe
Masashige
M
Kobayashi
Eiji
E
Sagawa
Hiroaki
H
Kato
Ikunoshin
I
D029969:Angelica / Q000737:chemistry*; D000818:Animals; D047188:Chalcones / Q000302:isolation & purification* / Q000627:therapeutic use*; D003920:Diabetes Mellitus / Q000517:prevention & control; D007004:Hypoglycemic Agents / Q000302:isolation & purification* / Q000627:therapeutic use*; D007328:Insulin / Q000494:pharmacology; D008297:Male; D051379:Mice; D047495:PPAR gamma / Q000187:drug effects; D010936:Plant Extracts / Q000737:chemistry
D047188:Chalcones; D007004:Hypoglycemic Agents; D007328:Insulin; D047495:PPAR gamma; D010936:Plant Extracts