title: Preliminary evidence for cognitive mediation during cognitive-behavioral therapy of panic disorder.
abstract: Cognitive-behavioral therapy (CBT) and pharmacotherapy are similarly effective for treating panic disorder with mild or no agoraphobia, but little is known about the mechanism through which these treatments work. The present study examined some of the criteria for cognitive mediation of treatment change in CBT alone, imipramine alone, CBT plus imipramine, and CBT plus placebo. Ninety-one individuals who received 1 of these interventions were assessed before and after acute treatment, and after a 6-month maintenance period. Multilevel moderated mediation analyses provided preliminary support for the notion that changes in panic-related cognitions mediate changes in panic severity only in treatments that include CBT.
authors.affiliation: Department of Psychology, Boston University, Boston, MA 02215, USA. shofmann@bu.edu
authors.forename: Stefan G
authors.initials: SG
authors.lastname: Hofmann
authors.forename: Alicia E
authors.initials: AE
authors.lastname: Meuret
authors.forename: David
authors.initials: D
authors.lastname: Rosenfield
authors.forename: Michael K
authors.initials: MK
authors.lastname: Suvak
authors.forename: David H
authors.initials: DH
authors.lastname: Barlow
authors.forename: Jack M
authors.initials: JM
authors.lastname: Gorman
authors.forename: M Katherine
authors.initials: MK
authors.lastname: Shear
authors.forename: Scott W
authors.initials: SW
authors.lastname: Woods
mesh_terms: D000328:Adult; D000368:Aged; D000929:Antidepressive Agents, Tricyclic / Q000627:therapeutic use; D003071:Cognition; D015928:Cognitive Behavioral Therapy / Q000379:methods*; D005260:Female; D006801:Humans; D007099:Imipramine / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D017008:Negotiating; D016584:Panic Disorder / Q000175:diagnosis / Q000188:drug therapy / Q000628:therapy*; D011795:Surveys and Questionnaires
chemical_list: D000929:Antidepressive Agents, Tricyclic; D007099:Imipramine