Pentylenetetrazol-induced seizures are not altered by pre- or post-drug exposure to a 50 Hz magnetic field.
OBJECTIVE
To investigate whether pre- and post-drug magnetic field (MF) exposure of 50 Hz, 0.2 mT has any significant effect on pentylenetetrazol (PTZ)-induced seizures in mice.


METHODS
MF was generated by a pair of Helmholtz coils. Seizures were induced by PTZ injection intraperitoneally (i.p.) at a dose of 60 mg/kg. A total of 48 locally bred adult female mice 25-35 g in weight were used. Latency to seizure, total seizure duration, and mortality were recorded for each mouse.


RESULTS
Neither pre- nor post-drug exposure to a 50 Hz, 0.2 mT MF was found to have any effect on PTZ-induced epileptic seizures or mortality rates in mice.


CONCLUSIONS
The present study failed to provide any support for a therapeutic potential of a 50 Hz, 0.2 mT MF for epilepsy.
Canseven
Ayse G
AG
Department of Biophysics, Gazi University Medical Faculty, and Gazi Non-Ionizing Radiation Protection Center, Ankara, Turkey. canseven@gazi.edu.tr
Keskil
Zuhal Aktuna
ZA
Keskil
Semih
S
Seyhan
Nesrin
N
D000818:Animals; D001921:Brain / Q000503:physiopathology* / Q000528:radiation effects*; D004560:Electricity; D004574:Electromagnetic Fields; D005260:Female; D051379:Mice; D010433:Pentylenetetrazole; D012640:Seizures / Q000139:chemically induced* / Q000503:physiopathology* / Q000517:prevention & control; D015996:Survival Rate
D010433:Pentylenetetrazole