title: [Clinical features of acute viral hepatitis A complicated with acute renal failure].
abstract: BACKGROUND
  Most patients with acute viral hepatitis A (AVHA) spontaneously recover, but a few patients experience complications. This study was carried out to examine clinical features of AVHA complicated with acute renal failure (ARF).
  
  
  METHODS
  Medical records of 404 patients with AVHA were reviewed. Clinical features of AVHA patients with ARF (group A) were compared with those of AVHA patients without ARF (group B).
  
  
  RESULTS
  ARF complication was present in 11 patients (3%). There were no differences between group A and B in sex ratio and age. Microscopic hematuria (7 cases), proteinuria (7 cases), metabolic acidosis (4 cases), oliguria (4 cases), pulmonary edema (3 cases) and hyperkalemia (2 cases) were found in group A. The prevalence of heavy alcohol drinking (64% vs 3%, p<0.001) and diabetes mellitus (18% vs 1%, p=0.01) was higher in group A than B. The peak value of ALT (median: 4,290 IU/L vs 1,266 IU/L, p=0.006) and total bilirubin (median: 10.8 mg/dL vs 6.0 mg/dL, p=0.001) was higher in group A than B. Duration of admission was longer in group A than B (median: 14 days vs 5 days, p<0.001). Four patients of group A recovered with renal replacement therapy, while 7 patients recovered with conservative treatment.
  
  
  CONCLUSIONS
  The AVHA patients with ARF experienced more severe hepatitis than those without ARF, but they had a good prognosis with the proper treatment.
authors.affiliation: Department of Internal Medicine, Gachon Medical College, Inchon, Korea.
authors.forename: Kee Sup
authors.initials: KS
authors.lastname: Song
authors.forename: Min Ju
authors.initials: MJ
authors.lastname: Kim
authors.forename: Chang Soo
authors.initials: CS
authors.lastname: Jang
authors.forename: Hyuk Sang
authors.initials: HS
authors.lastname: Jung
authors.forename: Hyun Hee
authors.initials: HH
authors.lastname: Lee
authors.forename: Oh Sang
authors.initials: OS
authors.lastname: Kwon
authors.forename: Yun Soo
authors.initials: YS
authors.lastname: Kim
authors.forename: Duck Joo
authors.initials: DJ
authors.lastname: Choi
authors.forename: Ju Hyun
authors.initials: JH
authors.lastname: Kim
authors.forename: Seung Yeon
authors.initials: SY
authors.lastname: Ha
mesh_terms: D000208:Acute Disease; D058186:Acute Kidney Injury / Q000821:virology*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000410:Alanine Transaminase / Q000032:analysis; D001663:Bilirubin / Q000032:analysis; D015415:Biomarkers / Q000097:blood; D002648:Child; D003920:Diabetes Mellitus / Q000453:epidemiology; D005260:Female; D006506:Hepatitis A / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011379:Prognosis; D012189:Retrospective Studies
chemical_list: D015415:Biomarkers; D000410:Alanine Transaminase; D001663:Bilirubin