title: Imatimid-induced bone marrow necrosis detected on MRI examination and mimicking bone metastases.
abstract: Imatinib has revolutionized the treatment and prognosis of patients with gastrointestinal stromal tumors (GIST). In contrast to liver and/or abdominal involvement, bone metastases are an uncommon event in GIST. We report here two patients with metastatic GIST who developed pelvic bone marrow focal lesions visible on MRI examinations, while Imatinib dramatically improved other tumor sites. A biopsy in one patient diagnosed bone marrow necrosis. The other patient had a favorable follow-up over several years, without bone metastases. Focal bone marrow abnormalities, detected on MRI examinations and mimicking bone metastases in patients who were otherwise responding, should be considered as probable bone marrow necrosis.
authors.affiliation: Institut Gustave Roussy, Villejuif, France. vanel@igr.fr
authors.forename: D
authors.initials: D
authors.lastname: Vanel
authors.forename: S
authors.initials: S
authors.lastname: Bonvalot
authors.forename: C Le
authors.initials: CL
authors.lastname: Pechoux
authors.forename: A
authors.initials: A
authors.lastname: Cioffi
authors.forename: J
authors.initials: J
authors.lastname: Domont
authors.forename: A Le
authors.initials: AL
authors.lastname: Cesne
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects; D001549:Benzamides; D001855:Bone Marrow Diseases / Q000139:chemically induced* / Q000175:diagnosis*; D001859:Bone Neoplasms / Q000175:diagnosis* / Q000556:secondary; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D046152:Gastrointestinal Stromal Tumors / Q000188:drug therapy*; D006801:Humans; D000068877:Imatinib Mesylate; D008279:Magnetic Resonance Imaging; D008297:Male; D009336:Necrosis; D010384:Pelvic Bones / Q000473:pathology*; D010879:Piperazines / Q000009:adverse effects*; D047428:Protein Kinase Inhibitors / Q000009:adverse effects; D011743:Pyrimidines / Q000009:adverse effects*; D012074:Remission Induction
chemical_list: D000970:Antineoplastic Agents; D001549:Benzamides; D010879:Piperazines; D047428:Protein Kinase Inhibitors; D011743:Pyrimidines; D000068877:Imatinib Mesylate