Biological matrices and bionanotechnology.
A crucial step towards the goal of tissue engineering a heart valve will be the choice of scaffold onto which an appropriate cell phenotype can be seeded. Successful scaffold materials should be amenable to modification, have a controlled degradation, be compatible with the cells, lack cytotoxicity and not elicit an immune or inflammatory response. In addition, the scaffold should induce appropriate responses from the cells seeded onto it, such as cell attachment, proliferation and remodelling capacity, all of which should promote the formation of a tissue construct that can mimic the structure and function of the native valve. This paper discusses the various biological scaffolds that have been considered and are being studied for use in tissue engineering a heart valve. Also, strategies to enhance the biological communication between the scaffold and the cells seeded onto it as well as the use of bionanotechnology in the manufacture of scaffolds possessing the desired properties will be discussed.
Taylor
Patricia M
PM
Department of Cardiothoracic Surgery, Heart Science Centre, Harefield Hospital, NHLI, Imperial College London, Middlesex UB9 6JH, UK. patricia.taylor@imperial.ac.uk
D001021:Aortic Valve / Q000033:anatomy & histology / Q000502:physiology; D001672:Biocompatible Materials; D001709:Biotechnology / Q000379:methods*; D005109:Extracellular Matrix / Q000378:metabolism*; D006801:Humans; D036103:Nanotechnology / Q000379:methods*; D023822:Tissue Engineering / Q000379:methods*
D001672:Biocompatible Materials