title: The role of the cerebellum in schizophrenia: an update of clinical, cognitive, and functional evidences.
abstract: The role of the cerebellum in schizophrenia has been highlighted by Andreasen's hypothesis of "cognitive dysmetria," which suggests a general dyscoordination of sensorimotor and mental processes. Studies in schizophrenic patients have brought observations supporting a cerebellar impairment: high prevalence of neurological soft signs, dyscoordination, abnormal posture and propioception, impaired eyeblink conditioning, impaired adaptation of the vestibular-ocular reflex or procedural learning tests, and lastly functional neuroimaging studies correlating poor cognitive performances with abnormal cerebellar activations. Despite those compelling evidences, there has been, to our knowledge, no recent review on the clinical, cognitive, and functional literature supporting the role of the cerebellum in schizophrenia. We conducted a Medline research focusing on cerebellar dysfunctions in schizophrenia. Emphasis was given to recent literature (after 1998). The picture arising from this review is heterogeneous. While in some domains, the role of the cerebellum seems clearly defined (ie, neurological soft signs, posture, or equilibrium), in other domains, the cerebellar contribution to schizophrenia seems limited or indirect (ie, cognition) if present at all (ie, affectivity). Functional models of the cerebellum are proposed as a background for interpreting these results.
authors.affiliation: INSERM U796, Pathophysiology of psychiatric diseases, University Paris Descartes, Sainte-Anne Hospital, Paris, France. picard@broca.inserm.fr
authors.forename: Hernàn
authors.initials: H
authors.lastname: Picard
authors.forename: Isabelle
authors.initials: I
authors.lastname: Amado
authors.forename: Sabine
authors.initials: S
authors.lastname: Mouchet-Mages
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Olié
authors.forename: Marie-Odile
authors.initials: MO
authors.lastname: Krebs
mesh_terms: D000339:Affect; D002531:Cerebellum / Q000503:physiopathology*; D003072:Cognition Disorders / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology*; D006212:Hallucinations / Q000453:epidemiology; D006801:Humans; D007802:Language; D007858:Learning; D008279:Magnetic Resonance Imaging; D008569:Memory Disorders / Q000175:diagnosis / Q000453:epidemiology; D011187:Posture; D011434:Proprioception / Q000502:physiology; D012021:Reflex, Abnormal; D012027:Reflex, Vestibulo-Ocular / Q000502:physiology; D012559:Schizophrenia / Q000453:epidemiology* / Q000503:physiopathology*