Protective effects of Platycodi radix on alcohol-induced fatty liver.
The protective effects of Platycodi radix (PR), the root of Platycodon grandiflorum A. DC, on alcohol-induced fatty liver and possible mechanisms involved in this protection were investigated in rats. Administration of PR significantly prevented alcohol-induced elevation of serum and liver lipids. Furthermore, PR treatment normalized hepatic liver fatty acid binding protein (L-FABP) expression and cytochrome P450 2E1 (CYP2E1) activity in alcohol-treated rats. These results suggest that inhibition of CYP2E1 and regulation of L-FABP by PR play an important role in alcohol-induced hepatoprotection.
Kim
Hye Kyung
HK
Department of Food and Biotechnology, Hanseo University, Korea.
Kim
Dong-Sub
DS
Cho
Hong-Yon
HY
D000438:Alcohols / Q000009:adverse effects; D000818:Animals; D065691:Cytochrome P-450 CYP2E1 Inhibitors; D050556:Fatty Acid-Binding Proteins / Q000235:genetics*; D005234:Fatty Liver / Q000139:chemically induced / Q000188:drug therapy*; D005786:Gene Expression Regulation / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry; D031238:Platycodon / Q000737:chemistry*; D020011:Protective Agents / Q000494:pharmacology; D051381:Rats
D000438:Alcohols; D065691:Cytochrome P-450 CYP2E1 Inhibitors; D050556:Fatty Acid-Binding Proteins; D010936:Plant Extracts; D020011:Protective Agents