Pyridine elaboration through organometallic intermediates: regiochemical control and completeness.
Pyridines carrying heterosubstituents (such as carboxy, amido, amino, alkoxy or trifluoromethyl groups or solely individual halogen atoms) can be readily and site selectively metalated. Subsequent reaction with a suitable electrophile opens rational access to a wealth of new building blocks for the synthesis of biologically active compounds. This approach relies on organometallic methods, which are both efficacious and extremely flexible as far as the substitution site and the product structure are concerned (86 references).
Schlosser
Manfred
M
Institute of Chemical Sciences and Engineering (ISIC), Ecole Polytechnique Fédérale, BCh, CH-1015 Lausanne, Switzerland. manfred.schlosser@epfl.ch
Mongin
Florence
F
D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D011726:Pyridinium Compounds / Q000737:chemistry*; D013237:Stereoisomerism
D009942:Organometallic Compounds; D011726:Pyridinium Compounds