title: High and low frequency electrical stimulation in non-lesional temporal lobe epilepsy.
abstract: In patients with pharmacologically intractable epilepsy who are not eligible for surgery, deep brain stimulation is currently under evaluation as an alternative treatment. Optimal stimulation parameters, including high (HFS) versus low frequency (LFS) stimulation, are not well defined. Here, we report the effects of HFS (130 pulses per second, pps) and LFS (5pps) of the principal epileptogenic focus, in three patients with non-lesional temporal lobe epilepsy. HFS, but not LFS, was associated with a reduction of the interictal discharges and absence of seizures. HFS may be beneficial in patients with non-lesional temporal lobe epilepsy who are not surgical candidates.
authors.affiliation: Presurgical Epilepsy Evaluation Unit, Department of Neurology, University Hospital of Geneva, Switzerland. Colette.Boex@hcuge.ch
authors.forename: Colette
authors.initials: C
authors.lastname: Boëx
authors.forename: Serge
authors.initials: S
authors.lastname: Vulliémoz
authors.forename: Laurent
authors.initials: L
authors.lastname: Spinelli
authors.forename: Claudio
authors.initials: C
authors.lastname: Pollo
authors.forename: Margitta
authors.initials: M
authors.lastname: Seeck
mesh_terms: D000328:Adult; D004307:Dose-Response Relationship, Radiation; D004558:Electric Stimulation / Q000379:methods*; D004833:Epilepsy, Temporal Lobe / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male