Patch test reactivity to a cobalt-chromium-molybdenum alloy and stainless steel in metal-allergic patients in correlation to the metal ion release.
Nickel, chromium, and cobalt released from stainless steel and CoCrMo alloys have been postulated to trigger hypersensitivity reactions. The objective of this study was to assess the ion release from a CoCrMo alloy and stainless steel in vitro and the cutaneous reactivity to it by patch test. 52 metal-allergic patients and 48 non-allergic controls were patch tested to stainless steel and CoCrMo discs. In addition, using atomic absorption spectrometry, the release of nickel, cobalt, and chromium from both materials was assessed upon 2-day exposure to distilled water, artificial sweat (AS), and cell culture medium. There was low nickel ion release from stainless steel (0.3-0.46 microg/cm(2)/2 days) and CoCrMo discs (up to 0.33 microg/cm(2)/2 days) into the different elution media. Chromium release from the 2 materials was also very low (0.06-0.38 microg/cm(2)/2 days from stainless steel and 0.52-1.36 microg/cm(2)/2 days from CoCrMo alloy). In contrast, AS led to abundant cobalt release (maximally 18.94 microg/cm(2)/2 days) from the CoCrMo discs, with concomitant eczematous reaction upon patch testing: 0 of the 52 metal-allergic patients reacted to stainless steel discs and 5 of the 52 patients to CoCrMo discs (all 5 patients were cobalt allergic and 3 also nickel and chromium allergic). None of the controls reacted to the discs. Apart from nickel being a focus of allergological research, our results point to the possibly underestimated association of cobalt release and potential hyperreactivity to CoCrMo alloy.
Summer
Burkhard
B
Klinik und Poliklinik für Dermatologie und Allergologie der, Ludwig-Maximilians-Universität München, Frauenlobstr. 9-11, D-80337 München, Germany. burkhard.summer@med.uni-muenchen.de
Fink
Ulrich
U
Zeller
Richard
R
Rueff
Franziska
F
Maier
Sonja
S
Roider
Gabriele
G
Thomas
Peter
P
D000328:Adult; D000368:Aged; D000497:Alloys / Q000737:chemistry; D002857:Chromium / Q000009:adverse effects* / Q000032:analysis; D003035:Cobalt / Q000009:adverse effects* / Q000032:analysis; D003470:Culture Media; D017449:Dermatitis, Allergic Contact / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009532:Nickel / Q000009:adverse effects* / Q000032:analysis; D010328:Patch Tests; D013054:Spectrophotometry, Atomic; D013193:Stainless Steel / Q000009:adverse effects* / Q000737:chemistry; D013542:Sweat
D000497:Alloys; D003470:Culture Media; D002857:Chromium; D013193:Stainless Steel; D003035:Cobalt; D009532:Nickel