Impact of the Haemophilus influenzae type b vaccination program on HIB meningitis in Brazil.
This study aimed to evaluate the impact of vaccination against Haemophilus influenzae type b (HIB) in Brazil on the morbidity, mortality, and case fatality of HIB meningitis, using the Ministry of Health database and population data from the Brazilian Institute of Geography and Statistics (Instituto Brasileiro de Geografia e Estatística--IBGE). Impact was evaluated through a time series analysis (1983-2002), using regression forecasting (RF) by dividing the time series into two periods: (a) historical (1983-1998) and (b) validation (1999-2002). Impact of the vaccination was positive, although more significant for incidence and mortality than for case fatality rates.
Miranzi
Sybelle de Souza Castro
Sde S
Departamento de Medicina Social, Universidade Federal do Triângulo Mineiro, Uberaba, Brasil.
de Moraes
Suzana Alves
SA
de Freitas
Isabel Cristina Martins
IC
D001938:Brazil / Q000453:epidemiology; D002675:Child, Preschool; D002984:Clinical Laboratory Information Systems; D005544:Forecasting; D018073:Haemophilus Vaccines / Q000008:administration & dosage*; D019741:Haemophilus influenzae type b / Q000276:immunology*; D006801:Humans; D017589:Immunization Programs; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008583:Meningitis, Haemophilus / Q000453:epidemiology* / Q000401:mortality / Q000517:prevention & control*; D012044:Regression Analysis; D016019:Survival Analysis; D014611:Vaccination / Q000592:standards*; D018074:Vaccines, Conjugate
D018073:Haemophilus Vaccines; D018074:Vaccines, Conjugate