Review of clinical trials of skin antiseptic agents used to reduce blood culture contamination.
False-positive blood culture results may lead to prolonged hospitalization, inappropriate antibiotic administration, and increased healthcare costs. We conducted a review of the literature to assess the effect of skin antiseptic agents on the rate of false-positive blood culture results. We found no clear evidence to suggest which antiseptic should be used to prevent false-positive results. Studies suggest, however, a possible benefit from the use of prepackaged skin antiseptic kits and alcohol-containing antiseptics.
Malani
Anurag
A
Division of Infectious Diseases, University of Michigan Medical School, Ann Arbor, MI, USA. malanian@med.umich.edu
Trimble
Kim
K
Parekh
Vikas
V
Chenoweth
Carol
C
Kaufman
Samuel
S
Saint
Sanjay
S
D019840:2-Propanol / Q000008:administration & dosage; D000287:Administration, Topical; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage*; D001769:Blood / Q000382:microbiology*; D002710:Chlorhexidine / Q000008:administration & dosage; D002986:Clinical Trials as Topic; D005189:False Positive Reactions; D006801:Humans; D007455:Iodine / Q000008:administration & dosage; D011206:Povidone-Iodine / Q000008:administration & dosage; D012867:Skin / Q000187:drug effects / Q000382:microbiology*
D000891:Anti-Infective Agents, Local; D011206:Povidone-Iodine; D007455:Iodine; D019840:2-Propanol; D002710:Chlorhexidine