title: The effect of antireflux surgery on esophageal carcinogenesis in patients with barrett esophagus: a systematic review.
abstract: OBJECTIVE
  To determine whether patients with Barrett esophagus who undergo antireflux surgery differ from medically treated patients in incidence of esophageal adenocarcinoma and probability of disease regression/progression.
  
  
  BACKGROUND
  Barrett esophagus is a risk factor for the development of esophageal adenocarcinoma. A question exists as to whether antireflux surgery reduces this risk.
  
  
  METHODS
  Query of PubMed (1966 through October 2005) using predetermined search terms revealed 2011 abstracts, of which 100 full-text articles were reviewed. Twenty-five articles met selection criteria. A review of article references and consultation with experts revealed additional articles for inclusion. Studies that enrolled adults with biopsy-proven Barrett esophagus, specified treatment-type rendered, followed up patients with endoscopic biopsies no less than12 months of instituting therapy, and provided adequate extractable data. The incidence of adenocarcinoma and the proportion of patients developing progression or regression of Barrett esophagus and/or dysplasia were extracted.
  
  
  RESULTS
  In surgical and medical groups, 700 and 996 patients were followed for a total of 2939 and 3711 patient-years, respectively. The incidence rate of esophageal adenocarcinoma was 2.8 (95% confidence interval, 1.2-5.3) per 1000 patient-years among surgically treated patients and 6.3 (3.6-10.1) among medically treated patients (P = 0.034). Heterogeneity in incidence rates in surgically treated patients was observed between controlled studies and case series (P = 0.014). Among controlled studies, incidence rates were 4.8 (1.7-11.1) and 6.5 (2.6-13.8) per 1000 patient-years in surgical and medical patients, respectively (P = 0.320). Probability of progression was 2.9% (1.2-5.5) in surgical patients and 6.8% (2.6-12.1) in medical patients (P = 0.054). Probability of regression was 15.4% (6.1-31.4) in surgical patients and 1.9% (0.4-7.3) in medical patients (P = 0.004).
  
  
  CONCLUSIONS
  Antireflux surgery is associated with regression of Barrett esophagus and/or dysplasia. However, evidence suggesting that surgery reduces the incidence of adenocarcinoma is largely driven by uncontrolled studies.
authors.affiliation: Department of Surgery, Oregon Health & Science University, Portland, OH, USA.
authors.forename: Eugene Y
authors.initials: EY
authors.lastname: Chang
authors.forename: Cynthia D
authors.initials: CD
authors.lastname: Morris
authors.forename: Ann K
authors.initials: AK
authors.lastname: Seltman
authors.forename: Robert W
authors.initials: RW
authors.lastname: O'Rourke
authors.forename: Benjamin K
authors.initials: BK
authors.lastname: Chan
authors.forename: John G
authors.initials: JG
authors.lastname: Hunter
authors.forename: Blair A
authors.initials: BA
authors.lastname: Jobe
mesh_terms: D000230:Adenocarcinoma / Q000453:epidemiology / Q000473:pathology* / Q000517:prevention & control; D001471:Barrett Esophagus / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D001706:Biopsy; D018450:Disease Progression; D016099:Endoscopy, Gastrointestinal / Q000379:methods*; D004938:Esophageal Neoplasms / Q000453:epidemiology / Q000473:pathology* / Q000517:prevention & control; D006801:Humans; D015994:Incidence; D011230:Precancerous Conditions; D016896:Treatment Outcome; D014481:United States / Q000453:epidemiology