Diterpenoids from Turraeanthus mannii.
Three new compounds, 15-acetoxy-12-hydroxy-16-methyl-labda-8(17),13E-diene (1), ent-labda-8(17),13-dien-15,16-olid-19-oic acid methyl ester (2), and 12-hydroxy-labda-8(17),13-dien-15,16-olide (3), together with two known compounds, 19-acetoxy-ent-labda-8(17),13-dien-15,16-olide (4), and 16-acetoxy-12,15-epoxy-15beta-hydroxy-labda-8(17),13(16)-diene (5) were isolated from the stem bark of Turraeanthus mannii (Meliaceae). The structures of compounds 1 - 3 were elucidated by analysis of the spectroscopic data. The crude methanol extract and compound 5 exhibited weak antibacterial and antifungal activity.
Vardamides
Juliette Catherine
JC
Department of Organic Chemistry, University of Douala, Douala, Cameroon. jucthmas@yahoo.fr
Sielinou
Valerie Tedjon
VT
Ndemangou
Brigitte
B
Nkengfack
Augustin Ephrem
AE
Fomum
Zacharias Tanee
ZT
Poumale
Herve Martial Poumale
HM
Laatsch
Hartmut
H
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D005591:Chemical Fractionation; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D029582:Meliaceae / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D019906:Nuclear Magnetic Resonance, Biomolecular; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
C495477:16-acetoxy-12(R),15-epoxy-15beta-hydroxylabda-8(17),13(16)-diene; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D004224:Diterpenes; D010936:Plant Extracts