title: Role of flavonoids and vitamins in cancer.
abstract: Flavonoids are naturally occurring polyphenolic plant compounds that are capable of inhibiting histamine and cytokine release from several cells. Many studies suggest that flavonoids are anticancer agents with an apoptotic effect on tumor cells. Studies with animal tumour models have found vitamin deficiency to enhance susceptibility to chemical carcinogenesis and large doses of anti-oxidant vitamins and flavonoids to inhibit carcinogenesis. In some studies flavonoids and/or vitamins were found to reduce the predisposition to develop tumours in animals and humans. In conclusion, in this review we describe the role of flavonoids and vitamins in cancer.
authors.affiliation: Department of Medicine and Aging, Medical School, University of Chieti-Pescara, Via dei Vestini, Chieti, Italy.
authors.forename: Maria Luisa
authors.initials: ML
authors.lastname: Castellani
authors.forename: Yazdani B
authors.initials: YB
authors.lastname: Shaik
authors.forename: Lakshmi Narayan
authors.initials: LN
authors.lastname: Shanmugham
authors.forename: Stavros
authors.initials: S
authors.lastname: Frydas
authors.forename: Bhuvaneshwari
authors.initials: B
authors.lastname: Madhappan
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Salini
authors.forename: Jacopo
authors.initials: J
authors.lastname: Vecchiet
authors.forename: Filiberto
authors.initials: F
authors.lastname: Mastrangelo
authors.forename: Graziano
authors.initials: G
authors.lastname: Riccioni
authors.forename: Fiorella
authors.initials: F
authors.lastname: Conti
authors.forename: Alessandro
authors.initials: A
authors.lastname: Perrella
authors.forename: Pio
authors.initials: P
authors.lastname: Conti
authors.forename: Stefano
authors.initials: S
authors.lastname: Tetè
mesh_terms: D000818:Animals; D005419:Flavonoids / Q000627:therapeutic use*; D006801:Humans; D009369:Neoplasms / Q000517:prevention & control*; D014815:Vitamins / Q000627:therapeutic use*
chemical_list: D005419:Flavonoids; D014815:Vitamins