title: PET evidence of central GABAergic changes in stiff-person syndrome.
abstract: We measured expression of central nervous system GABA-A receptors with (11)C-flumazenil ((11)C-FMZ) and PET in two subjects with stiff person syndrome (SPS). We found reduced (11)C-FMZ binding potential (BP) in motor-premotor cortex, and increased (11)C-FMZ BP in the cerebellar nuclei. This is the first in vivo PET evidence of central GABA-A receptors dysfunction in SPS, possibly concurring to the motor symptoms.
authors.affiliation: Istituto Nazionale di Neuroscienze, Vita-Salute San Raffaele University, Milan, Italy. daniela.perani@hsr.it
authors.forename: Daniela
authors.initials: D
authors.lastname: Perani
authors.forename: Valentina
authors.initials: V
authors.lastname: Garibotto
authors.forename: Andrea
authors.initials: A
authors.lastname: Panzacchi
authors.forename: Rosa Maria
authors.initials: RM
authors.lastname: Moresco
authors.forename: Paola
authors.initials: P
authors.lastname: Ortelli
authors.forename: Massimo
authors.initials: M
authors.lastname: Corbo
authors.forename: Ferruccio
authors.initials: F
authors.lastname: Fazio
authors.forename: Franco
authors.initials: F
authors.lastname: Folli
mesh_terms: D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D049268:Positron-Emission Tomography; D016750:Stiff-Person Syndrome / Q000000981:diagnostic imaging* / Q000378:metabolism* / Q000503:physiopathology; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
chemical_list: D005680:gamma-Aminobutyric Acid