title: Channel-forming activity of alamethicin: effects of covalent tethering.
abstract: In this short review article, the effects of covalent tethering of alamethicin molecules on channel-forming behavior are described. Broadly speaking, these chemical modifications have provided insight into all three aspects of channel behavior: the structure of the conducting state, the ion-selectivity and ion-permeation properties, and the voltage dependence. Each of these aspects are discussed in turn.
authors.affiliation: Department of Chemistry, University of Toronto, Toronto, ON, Canada. awoolley@chem.utoronto.ca
authors.forename: G Andrew
authors.initials: GA
authors.lastname: Woolley
mesh_terms: D000408:Alamethicin / Q000737:chemistry*; D007473:Ion Channels / Q000737:chemistry*; D011487:Protein Conformation
chemical_list: D007473:Ion Channels; D000408:Alamethicin