title: Comparative efficacy of pour-on and subcutaneous injection of ivermectin on Melophagus ovinus (L.) in Darab ecotype goats of Southern Iran.
abstract: The efficacy of ivermectin was evaluated against Melophagus ovinus in Darab ecotype goats of Iran. Twenty-four healthy Iranian crossbreed male goats were randomly divided into three equal groups (n = 8). An experimental infestation was induced in all animals of the three groups with 100 M. ovinus on the body of each animal. Groups 1 and 2 were treated with 1% ivermectin solution at a dosage of 0.5 mg/kg of body weight applied as a pour-on along the dorsal midline and 0.2 mg/kg subcutaneously, respectively; while group 3 was kept as control group. Seven days after infestation ivermectin was administered then the goats were observed for a period of 7 days. Body surface of each goat of three groups was inspected daily and decreases in M. ovinus were recorded. The rate of elimination in keds was assessed on the basis of decrease in keds count on the skin and hairs. The results revealed that complete absence of keds were observed in 6 and 7 days post-treatment with injection and pour-on routes, respectively. The results of present study showed that subcutaneous injection of ivermectin more rapidly eliminated M. ovinus than pour-on route. Both routes were 100% effective against this parasite in the goats. Ivermectin can be a drug of choice against M. ovinus in long-hair Iranian goats due to its high efficacy, easy applicability and wide safety margin.
authors.affiliation: Department of Clinical Sciences, School of Veterinary Medicine, Shiraz University, 1731, Shiraz 71345, Iran. sjafari@shirazu.ac.ir
authors.forename: S
authors.initials: S
authors.lastname: Jafari Shoorijeh
authors.forename: A
authors.initials: A
authors.lastname: Noori
authors.forename: A
authors.initials: A
authors.lastname: Tamadon
mesh_terms: D000287:Administration, Topical; D000818:Animals; D004175:Diptera / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004478:Ectoparasitic Infestations / Q000188:drug therapy / Q000662:veterinary*; D015511:Goat Diseases / Q000188:drug therapy*; D006041:Goats; D007279:Injections, Subcutaneous / Q000662:veterinary; D007306:Insecticides / Q000008:administration & dosage / Q000627:therapeutic use*; D007492:Iran; D007559:Ivermectin / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D011897:Random Allocation; D016896:Treatment Outcome
chemical_list: D007306:Insecticides; D007559:Ivermectin