title: Predicting memory: a prospective readout for malaria vaccines?
abstract: Malaria vaccines aim to induce long lasting protective immunity. Bejon and colleagues propose that levels of rapidly induced (effector memory) interleukin-2 and interferon gamma producing T-cells after vaccination with leading pre-erythrocytic stage vaccines predict the induction of resting memory responses (central memory). Herein we discuss Bejon's findings in the context of current thinking on the generation and maintenance of T cell memory, with particular emphasis on the role of cytokines.
authors.affiliation: Department of Immunology, Monash University, The Alfred Medical Research and Education Precinct, Prahran, Victoria 3181, Australia.
authors.forename: Gabriela
authors.initials: G
authors.lastname: Minigo
authors.forename: Karen
authors.initials: K
authors.lastname: Scalzo
authors.forename: Katie L
authors.initials: KL
authors.lastname: Flanagan
authors.forename: Magdalena
authors.initials: M
authors.lastname: Plebanski
mesh_terms: D000818:Animals; D006801:Humans; D007156:Immunologic Memory; D007371:Interferon-gamma / Q000096:biosynthesis* / Q000276:immunology; D007376:Interleukin-2 / Q000096:biosynthesis* / Q000276:immunology; D008288:Malaria / Q000276:immunology* / Q000517:prevention & control; D017780:Malaria Vaccines / Q000276:immunology*; D010961:Plasmodium / Q000276:immunology*; D011237:Predictive Value of Tests; D013997:Time Factors
chemical_list: D007376:Interleukin-2; D017780:Malaria Vaccines; D007371:Interferon-gamma