[Clinicopathological manifestations of drug-induced lung injury].
OBJECTIVE
To investigate the clinicopathological features of drug-induced lung injury.


METHODS
The clinical, radiological and pathological presentations of drug-induced lung injury diagnosed from January 2003 to October 2005 in Peking Union Medical College Hospital were reviewed.


RESULTS
There were 7 cases of drug-induced lung injury, 3 caused by amiodarone, and the other 4 caused by interferon-alpha, atorvastatin, carbamazepine, and propylthiouracil respectively. The clinical manifestations included cough, fever, worsening dyspnea and inspiratory crackles. Patchy infiltration, ground-glass attenuation with thickening of bronchovascular markings were the main findings in computed tomography. The most common pathological manifestation was cellular interstitial pneumonia associated with intra-alveolar macrophages with fine vacuolation in the cytoplasm, and type II pneumocyte hyperplasia. The organizing pneumonia pattern was observed in 2 patients. Diffuse alveolar hemorrhage was present in 2 cases.


CONCLUSIONS
Drug-induced pulmonary toxicity can be difficult to diagnose. The diagnosis of pulmonary drug toxicity should be considered in patients with a history of drug therapy and new onset or progressive respiratory complaints.
Shi
Ju-hong
JH
Department of Respiratory Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing 100730, China.
Yan
Xiao-wei
XW
Xu
Wen-bing
WB
Liu
Hong-rui
HR
Zhu
Yuan-jue
YJ
D000293:Adolescent; D000328:Adult; D000638:Amiodarone / Q000009:adverse effects; D005260:Female; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging / Q000473:pathology*; D055370:Lung Injury / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D008297:Male; D008875:Middle Aged; D014057:Tomography, X-Ray Computed; D055815:Young Adult
D000638:Amiodarone