title: Ameliorative anti-diabetic activity of dangnyosoko, a Chinese herbal medicine, in diabetic rats.
abstract: The preventive anti-diabetic effect of dangnyosoko (DNSK), a Chinese herbal medicine, was evaluated in STZ-induced diabetic rats. DNSK was orally administered once a day from 3 d after STZ-induction at 100, 200, and 500 mg/kg for 4 weeks, and the results were compared to those for glibenclamide. Dramatic decreases in body weight and plasma insulin levels and increases in blood and urine glucose levels were detected in STZ-induced diabetic animals with disruption and disappearance of pancreatic islets and increases in glucagon- and decreases in insulin-producing cells. However, these diabetic changes were significantly and dose-dependently inhibited by treatment with DNSK, and DNSK at 100 mg/kg showed more favorable effects than glibenclamide at 5 mg/kg. Based on these results, it is thought that DNSK has favorable effects in ameliorating changes in blood and urine glucose levels and body weight, and that histopathological changes in the pancreas in STZ induce diabetes.
authors.affiliation: College of Oriental Medicine, Daegu Haany University, Republic of Korea.
authors.forename: Jong-Dae
authors.initials: JD
authors.lastname: Kim
authors.forename: Seock-Man
authors.initials: SM
authors.lastname: Kang
authors.forename: Mee-Yeon
authors.initials: MY
authors.lastname: Park
authors.forename: Tae-Young
authors.initials: TY
authors.lastname: Jung
authors.forename: Hae-Yun
authors.initials: HY
authors.lastname: Choi
authors.forename: Sae-Kwang
authors.initials: SK
authors.lastname: Ku
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D013311:Streptozocin
chemical_list: D001786:Blood Glucose; D004365:Drugs, Chinese Herbal; D007004:Hypoglycemic Agents; C522932:dangnyosoko; D013311:Streptozocin