title: Multichannel biosensing platform of surface-immobilized gold nanospheres for linear and nonlinear optical imaging.
abstract: What we believe to be a new label-free multichannel biosensing platform is proposed. It is composed of surface-immobilized gold nanospheres (SIGNs) above a gold surface with a nanogap supported by a merocyanine self-assembled monolayer. The circular SIGN spots with a diameter of 120 microm were arrayed for multichannel biosensing on a glass slide. Two kinds of sensing methods were examined: One is a reflectivity measurement of a blue ray and the other is a second-harmonic generation measurement. It was found that the SIGN system can be used as a promising platform for multichannel biosensing in both sensing methods.
authors.affiliation: PRESTO, Japan Science and Technology Agency (JST), 4-1-8, Honcho, Kawaguchi, Saitama, 332-0012, Japan.
authors.forename: Kazuma
authors.initials: K
authors.lastname: Tsuboi
authors.forename: Shinya
authors.initials: S
authors.lastname: Fukuba
authors.forename: Ryo
authors.initials: R
authors.lastname: Naraoka
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Fujita
authors.forename: Kotaro
authors.initials: K
authors.lastname: Kajikawa
mesh_terms: D015374:Biosensing Techniques; D001710:Biotin / Q000737:chemistry; D004867:Equipment Design; D006046:Gold / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry*; D053758:Nanoparticles; D036103:Nanotechnology / Q000379:methods; D043942:Nanotubes / Q000737:chemistry; D055095:Optics and Photonics; D012542:Scattering, Radiation; D013499:Surface Properties; D013997:Time Factors
chemical_list: D001710:Biotin; D006046:Gold