Study on clinical effect and mechanism of jianpi qingre huayu recipe.
OBJECTIVE
To study the effects of Jianpi Qingre Huayu Recipe in curing gastric ulcer and to preliminarily probe into its pathogenic mechanism.


METHODS
Fifty patients with gastric ulcer of Pi -insufficiency and stasis-heat syndrome type were assigned to the treated group (30 patients) and the control group (20 patients). They were treated respectively with JQH and Ranitidine. At the same time, another group consisting of 20 healthy persons was set up for normal control. The clinical effect on gastroscopic figure and traditional Chinese medicine (TCM) syndrome were observed. Changes of T-cell subsets and interleukin-8 (IL-8) in serum as well as IL-8 in mucosa around the gastric ulcer were determined before and after treatment by flow cytometry and ELISA.


RESULTS
Comparison of the total effective rate on gastroscopic figure in the treated group and the control group (86.7% vs 80.0%) showed insignificant difference, but the cure rate and markedly effective rate in the former (50.0% and 20.0%) was higher than that in the latter (40.0% and 15.0%) respectively. Comparison of the total effective rate on TCM syndrome in the treated group and in the control group (96.7% vs 70.0%) showed insignificant difference, but the cure rate and markedly effective rate in the former (63.3% and 23.3%) was higher than that in the latter (50.0% and 20.0%) respectively. Serum levels of CD3+, CD4+, CD8+ got restored to normal range in the treated group after treatment but it was not so in the control group. IL-8 level in gastric mucosa was improved in both groups but the improvement in the treated group was better.


CONCLUSIONS
JQH could effectively treat gastric ulcer and partly reduce its recurrence through improving patients' immune function.
Zhou
Fu-Sheng
FS
Pi-wei Institute of Guangzhou University of Traditional Chinese Medicine, Guangzhou 510405. zhoufusheng123@yahoo.com
Hu
Li-Juan
LJ
Wang
Ru-Jun
RJ
Huang
Zhi-Xin
ZX
Luo
Qi
Q
D000328:Adult; D000897:Anti-Ulcer Agents / Q000627:therapeutic use; D001773:Blood Cells / Q000473:pathology; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005434:Flow Cytometry; D005753:Gastric Mucosa / Q000378:metabolism; D005773:Gastroscopy; D006801:Humans; D007107:Immune System / Q000473:pathology / Q000503:physiopathology; D016209:Interleukin-8 / Q000097:blood / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011899:Ranitidine / Q000627:therapeutic use; D013276:Stomach Ulcer / Q000175:diagnosis / Q000276:immunology / Q000378:metabolism / Q000628:therapy*; D016176:T-Lymphocyte Subsets / Q000473:pathology
D000897:Anti-Ulcer Agents; D004365:Drugs, Chinese Herbal; D016209:Interleukin-8; C521734:jianpi qingre huayu; D011899:Ranitidine