Immunohistochemical study on the distribution of canonical transient receptor potential channels in rat basal ganglia.
In the present study, we examined the localizations of canonical transient receptor potential channels (TRPCs) in rat basal ganglia. The dot-like staining pattern of TRPC5 was observed through the globus pallidus (GP) and caudate-putamen. TRPC7 had a strikingly high level of expression in the neuropil in the GP. In the subthalamic nucleus, strong staining for TRPC5 was observed in the cell bodies, while moderate to high immunoreactivies for TRPC1, TRPC3, TRPC4 and TRPC7 were found in the cell bodies and surrounding neuropil. In the substantia nigra, immunoreactivities for TRPC3 and TRPC7 were prominent in the cell bodies and several processes in the pars compacta and pars reticulata. TRPC6 was expressed in the neuropil, not in the cell bodies. This study may provide useful data for the future investigations on the structural and functional properties of TRPCs.
Chung
Yoon Hee
YH
Department of Anatomy, College of Medicine, Chung-Ang University, 221 Heukseok-Dong, Dongjak-Gu, Seoul 156-756, South Korea.
Kim
Daejin
D
Moon
Nam Joo
NJ
Oh
Chang Seok
CS
Lee
Eunju
E
Shin
Dong Hoon
DH
Kim
Sung Su
SS
Lee
Won Bok
WB
Lee
Jun-Young
JY
Cha
Choong Ik
CI
D000818:Animals; D001479:Basal Ganglia / Q000166:cytology / Q000378:metabolism*; D005455:Fluorescent Antibody Technique; D007150:Immunohistochemistry; D009474:Neurons / Q000378:metabolism; D019581:Neuropil / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D050051:Transient Receptor Potential Channels / Q000502:physiology*
D050051:Transient Receptor Potential Channels