[Effect of Shenshuai Yangzhen capsule on remnant renal tissue following 5/6 nephrectomy in malnutrition rats with chronic renal failure].
OBJECTIVE
To investigate effects of Shenshuai Yangzhen capsule, a preparation of traditional Chinese medicine, on remnant renal tissue following nephrectomy in malnutrition rats with chronic renal failure.


METHODS
SD rats were subjected to 5/6 nephrectomy and fed 4% casein diet to induce chronic renal failure (CRF), and their blood urea nitrogen (BUN), serum creatinine (Scr), serum albumin (ALB), hemoglobin (Hb), 24-hour urineprotein (24-h Upro) and body weight were measured. Upon the onset of malnutrition, the rats were randomized into CRF control group (CC), ketosteril group (KT), and Shenshuai Yangzhen group (SSYZ), with also a normal control group (NC). After 4 weeks of treatment as indicated, the remnant nephrotic tissue was examined under optical and electron microscopes and by immunofluorescence assay.


RESULTS
Malnutrition occurred in the CRF rats at the end of the 10th weeks after the operation. Compared with those in CC group, the plasma BUN, SCr and 24-h Upro levels in SSYZ group were significantly lower with substantially elevated plasma ALB and Hb. The pathological changes of SSYZ group was significantly improved after treatment with Shenshuai Yangzhen capsule.


CONCLUSIONS
Shenshuai Yangzhen capsule can improve malnutrition and reduce renal damage in rats with renal insufficiency.
Li
Yu-ming
YM
Department of Nephoropathy with Integrated Traditional Chinese and Western Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China. ming_li_882@hotmail.com
Wei
Lian-bo
LB
Deng
Cong
C
D000818:Animals; D001806:Blood Urea Nitrogen; D002214:Capsules; D003404:Creatinine / Q000097:blood; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects* / Q000601:surgery / Q000648:ultrastructure; D007676:Kidney Failure, Chronic / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D008297:Male; D044342:Malnutrition / Q000150:complications / Q000188:drug therapy*; D008854:Microscopy, Electron; D009392:Nephrectomy / Q000379:methods; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012709:Serum Albumin / Q000032:analysis; D016896:Treatment Outcome
D002214:Capsules; D004365:Drugs, Chinese Herbal; D012709:Serum Albumin; C549854:shenshuai yangzhen; D003404:Creatinine