title: Extrapyramidal symptoms in Frontotemporal Dementia: prevalence and clinical correlations.
abstract: In the present study we aimed at evaluating the prevalence and the associated clinical, neuropsychological and behavioral features of extrapyramidal symptoms in Frontotemporal Dementia (FTD) patients. Seventy-five patients fulfilling clinical criteria of FTD were consecutively enrolled. Each patient underwent clinical and extrapyramidal sign examination, and neuropsychological and behavioral disturbance evaluation. Each patient was submitted to both brain MRI and SPECT, documenting frontotemporal atrophy/hypoperfusion pattern. Parkinsonian symptoms in FTD were associated with a specific endophenotype characterized by higher incidence of psychotic symptoms, memory deficits and psychomotor speed ability abnormalities. Careful description of the spectrum of presentation of FTD may be of help for further understanding the underpinnings of the disease.
authors.affiliation: Department of Neurological Sciences, University of Brescia, Brescia, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Padovani
authors.forename: Chiara
authors.initials: C
authors.lastname: Agosti
authors.forename: Enrico
authors.initials: E
authors.lastname: Premi
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Bellelli
authors.forename: Barbara
authors.initials: B
authors.lastname: Borroni
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D001480:Basal Ganglia Diseases / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000209:etiology*; D003071:Cognition / Q000502:physiology; D003545:Cysteine / Q000031:analogs & derivatives; D003704:Dementia / Q000150:complications* / Q000000981:diagnostic imaging / Q000453:epidemiology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009483:Neuropsychological Tests; D015609:Organotechnetium Compounds; D011569:Psychiatric Status Rating Scales; D019275:Radiopharmaceuticals; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; C059659:technetium Tc 99m bicisate; D003545:Cysteine