Conversion of 3-arylazo-5-phenyl-2(3H)-furanones into other heterocycles of anticipated biological activity.
3-arylazo-5-phenyl-2(3H)-furanones 3 were prepared and converted into a variety of heterocyclic systems of synthetic and biological importance. Hydrazine hydrate reacted with furanones as nucleophiles and gave the corresponding acid hydrazides 4. The latter products were used as starting materials for the synthesis of 1,3,4-oxadiazoles 6, 9, and the 1,2,4-triazoles 8. Evaluation of the antiviral activity of selected compounds obtained was performed using two viruses: HAV and HSV-1. Some of the tested compounds showed promising activities.
Sayed
Hayam H
HH
Photochemistry Department, National Research Centre, Dokki, Giza, Egypt. hayamsayed@yahoo.com
Hashem
Ahmed I
AI
Yousif
Nabil M
NM
El-Sayed
Waled A
WA
D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001391:Azo Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D002522:Chlorocebus aethiops; D005663:Furans / Q000737:chemistry*; D030041:Hepatitis A virus / Q000187:drug effects; D018259:Herpesvirus 1, Human / Q000187:drug effects; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D014709:Vero Cells
D000998:Antiviral Agents; D001391:Azo Compounds; D005663:Furans; D006571:Heterocyclic Compounds; D015107:4-Butyrolactone