Synthesis of hyaluronic acid oligomers using Ph2SO/Tf2O-mediated glycosylations.
The synthesis of hyaluronic acid (HA) oligomers using a stepwise glycosylation strategy is described. This method employs protected 1-hydroxyuronic acid and 1-phenylthio glucosamine donors, both of which are activated with the Ph2SO/Tf2O activator system.
Dinkelaar
Jasper
J
Leiden Institute of Chemistry, Leiden University, P.O. Box 9502, 2300 RA Leiden, The Netherlands.
Codée
Jeroen D C
JD
van den Bos
Leendert J
LJ
Overkleeft
Herman S
HS
van der Marel
Gijsbert A
GA
D002240:Carbohydrate Sequence; D006031:Glycosylation; D006820:Hyaluronic Acid / Q000138:chemical synthesis*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008969:Molecular Sequence Data; D011108:Polymers / Q000138:chemical synthesis*
D011108:Polymers; D006820:Hyaluronic Acid