title: Polymorphisms of interleukin-10 and tumour necrosis factor-alpha genes are associated with newly diagnosed and recurrent pulmonary tuberculosis.
abstract: OBJECTIVE
  The genetic determinants for developing TB or having recurrent TB are unknown. The present study investigated the relationship between susceptibility to tuberculosis and human tumour necrosis factor-alpha (TNF-alpha) and interleukin-10 genes (IL-10).
  
  
  METHODS
  A case-control study was conducted using two groups of cases--newly diagnosed TB (N-TB) and recurrent TB (R-TB)--and a control group.
  
  
  RESULTS
  One hundred and seventeen healthy controls, 80 newly diagnosed TB patients and 65 patients with recurrent TB were enrolled. There was no significant difference in the TNF-alpha-308 G/A genotype between the TB patient groups and the controls. The IL-10 -1082A alleles were markedly over-represented among the TB patient groups compared with the control subjects, however, there was no significant difference in the IL-10 genotype frequency between the N-TB and R-TB patient groups.
  
  
  CONCLUSIONS
  The -1082A allele of the IL-10 gene may be important in determining susceptibility to TB, however, the -308 allele of the TNF-alpha gene does not affect differential TB susceptibility.
authors.affiliation: Department of Microbiology, College of Medicine, Chungnam University, Daejeon, Korea.
authors.forename: Jae-Hee
authors.initials: JH
authors.lastname: Oh
authors.forename: Chul-Su
authors.initials: CS
authors.lastname: Yang
authors.forename: Yeon-Kyeong
authors.initials: YK
authors.lastname: Noh
authors.forename: Yu-Mi
authors.initials: YM
authors.lastname: Kweon
authors.forename: Sung-Soo
authors.initials: SS
authors.lastname: Jung
authors.forename: Ji Woong
authors.initials: JW
authors.lastname: Son
authors.forename: Suck-Jun
authors.initials: SJ
authors.lastname: Kong
authors.forename: Jang Uk
authors.initials: JU
authors.lastname: Yoon
authors.forename: Ji-Sook
authors.initials: JS
authors.lastname: Lee
authors.forename: Hwa-Jung
authors.initials: HJ
authors.lastname: Kim
authors.forename: Jeong-Kyu
authors.initials: JK
authors.lastname: Park
authors.forename: Eun-Kyeong
authors.initials: EK
authors.lastname: Jo
authors.forename: Chang-Hwa
authors.initials: CH
authors.lastname: Song
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012008:Recurrence; D014397:Tuberculosis, Pulmonary / Q000235:genetics*; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
chemical_list: D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10