title: Population genetics of familial Mediterranean fever: a review.
abstract: In this review, some principal population genetic features of familial Mediterranean fever (FMF) are considered. These relate to the time and the place of founder mutations' origins, the role of ancient migrations and contacts between populations in the spatial spreading of the disorder, the influence of environmental factors and cultural traditions on the rate of FMF incidence, and possible selective advantage in carriers of FMF causing gene (MEFV) mutations.
authors.affiliation: Institute of Man, Yerevan, Armenia. lepiskop@gmail.com
authors.forename: Levon
authors.initials: L
authors.lastname: Yepiskoposyan
authors.forename: Ashot
authors.initials: A
authors.lastname: Harutyunyan
mesh_terms: D003466:Cultural Characteristics; D003598:Cytoskeletal Proteins / Q000235:genetics; D004641:Emigration and Immigration; D004777:Environment; D010505:Familial Mediterranean Fever / Q000235:genetics*; D005828:Genetics, Population; D006579:Heterozygote; D006801:Humans; D009154:Mutation; D000071198:Pyrin; D012641:Selection, Genetic
chemical_list: D003598:Cytoskeletal Proteins; C000604192:MEFV protein, human; D000071198:Pyrin