title: Antifungal activity in triterpene glycosides from the sea cucumber Actinopyga lecanora.
abstract: Bioassay-guided fractionation of methanol extract of sea cucumber Actinopyga lecanora led to the isolation of a new triterpene glycoside (1), along with two known glycosides holothurin B (3) and holothurin A (4). The structure has been elucidated on the basis of extensive 2D NMR spectroscopic analysis. The saponin (3) showed in vitro antifungal activity against all the twenty fungal test isolates including ATCC strain and was found to be most effective against Trychophyton mentagrophytes and Sporothrix schenckii, MIC range of 1.56 microg/ml.
authors.affiliation: Medicinal and Process Chemistry Division, Central Drug Research Institute, Chattar Manzil palace, Lucknow 226001, India.
authors.forename: Rajesh
authors.initials: R
authors.lastname: Kumar
authors.forename: Ashok Kumar
authors.initials: AK
authors.lastname: Chaturvedi
authors.forename: Praveen Kumar
authors.initials: PK
authors.lastname: Shukla
authors.forename: Vijai
authors.initials: V
authors.lastname: Lakshmi
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology*; D006027:Glycosides / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D012616:Sea Cucumbers / Q000737:chemistry*; D014315:Triterpenes / Q000494:pharmacology*
chemical_list: D000935:Antifungal Agents; D006027:Glycosides; D014315:Triterpenes