title: [Toll-like receptors, a new way of treatment?].
abstract: Toll-like receptors (TLRs) comprise a group of recently discovered receptors which are essential molecular structures in the activation of immunity. The discovery of TLRs has provided a substantial increase in the knowledge of immunologic aspects of disease pathology and is presently giving rise to new treatment strategies. This review summarizes the current knowledge on TLRs functioning in infections, their possible roles in inflammatory bowl disease and the pivotal role for TLRs in endotoxic shock, an area which is currently subject to development of a new farmakon.
authors.affiliation: Arhus Universitetshospital, Infektionsmedicinsk Afdeling Q, Skejby, Arhus N. claus_vinter@hotmail.com
authors.forename: Claus Vinter Bødker
authors.initials: CV
authors.lastname: Pedersen
authors.forename: Lars J
authors.initials: LJ
authors.lastname: Østergaard
authors.forename: Trine H
authors.initials: TH
authors.lastname: Mogensen
authors.forename: Søren Riis
authors.initials: SR
authors.lastname: Paludan
authors.forename: Lone Skovbo
authors.initials: LS
authors.lastname: Bertelsen
mesh_terms: D000818:Animals; D001424:Bacterial Infections / Q000188:drug therapy / Q000209:etiology / Q000276:immunology; D004187:Disaccharides / Q000627:therapeutic use; D006801:Humans; D007113:Immunity, Innate; D015212:Inflammatory Bowel Diseases / Q000188:drug therapy / Q000209:etiology / Q000276:immunology; D012772:Shock, Septic / Q000188:drug therapy / Q000209:etiology / Q000276:immunology; D013403:Sugar Phosphates / Q000627:therapeutic use; D051193:Toll-Like Receptors / Q000187:drug effects / Q000276:immunology / Q000502:physiology; D014777:Virus Diseases / Q000188:drug therapy / Q000209:etiology / Q000276:immunology
chemical_list: D004187:Disaccharides; D013403:Sugar Phosphates; D051193:Toll-Like Receptors; C512420:eritoran