Reversible cardiomyopathy due to secondary hemochromatosis with multitransfusions for severe aplastic anemia after successful non-myeloablative stem cell transplantation.
A 30-year-old Japanese woman with acquired severe aplastic anemia (SAA), diagnosed 20 years ago, was referred to our institution for allogeneic stem cell transplantation (SCT). As an unusual case of long-standing SAA, the patient was complicated with moderate heart failure due to secondary hemochromatosis. After successful SCT using a non-myeloablative conditioning regimen, she needed no transfusion. Five years after SCT, echocardiography showed a dramatic improvement of her cardiac function. This case indicates that the cardiac function in secondary hemochromatosis could be reversed once iron overload from multitransfusions is stopped.
Nishio
M
M
Endo
T
T
Nakao
S
S
Sato
N
N
Koike
T
T
D000328:Adult; D000741:Anemia, Aplastic / Q000209:etiology / Q000601:surgery*; D009202:Cardiomyopathies / Q000209:etiology / Q000601:surgery*; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006432:Hemochromatosis / Q000150:complications / Q000601:surgery*; D006801:Humans; D019190:Iron Overload / Q000209:etiology / Q000601:surgery; D033581:Stem Cell Transplantation / Q000379:methods; D065227:Transfusion Reaction