title: Sialyl oligosaccharides of human colostrum: changes in concentration during the first three days of lactation.
abstract: Sialyl oligosaccharides of human milk/colostrum are generally believed to be of biological significance, for example with respect to anti-adhesion of pathogenic organism, providing precursors for biosynthesis of brain, and so on. However, the levels of each of the sialyl oligosaccharides in human colostrum have not so far been determined. The present study was designed to determine the concentrations of nine major sialyl oligosaccharides in human colostrum, collected during the first 3 d (days 1-3) from the start of lactation. We found that the concentration of 3'-sialyllactose was significantly higher on day 1 than on day 2 and 3, but the levels of 6'-sialyllactose and sialyllacto-N-tetraose a were higher on day 3 than on day 1. These results are consistent with the view that during the first 3 d of lactation, the concentration of sialyl oligosaccharides in human colostrum change in accordance with the physiological demands of newborn infants.
authors.affiliation: Graduate School of Food Hygiene, Obihiro University of Agriculture and Veterinary Medicine, Japan.
authors.forename: Sadaki
authors.initials: S
authors.lastname: Asakuma
authors.forename: Maiko
authors.initials: M
authors.lastname: Akahori
authors.forename: Kazumasa
authors.initials: K
authors.lastname: Kimura
authors.forename: Yoko
authors.initials: Y
authors.lastname: Watanabe
authors.forename: Tadashi
authors.initials: T
authors.lastname: Nakamura
authors.forename: Makoto
authors.initials: M
authors.lastname: Tsunemi
authors.forename: Ikichi
authors.initials: I
authors.lastname: Arai
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Sanai
authors.forename: Tadasu
authors.initials: T
authors.lastname: Urashima
mesh_terms: D000222:Adaptation, Physiological; D003126:Colostrum / Q000737:chemistry* / Q000378:metabolism; D005260:Female; D006801:Humans; D007774:Lactation / Q000378:metabolism*; D007785:Lactose / Q000031:analogs & derivatives / Q000032:analysis; D008895:Milk, Human / Q000737:chemistry; D009844:Oligosaccharides / Q000032:analysis* / Q000096:biosynthesis; D011247:Pregnancy; D013997:Time Factors
chemical_list: C421467:3'-sialyllactose; C403777:6'-sialyllactose; C415922:NE 1530; D009844:Oligosaccharides; C016735:sialooligosaccharides; D007785:Lactose