[Prenatal exposure to psychoactive substances: results of NENUPHAR study].
The aim of this study is to describe the impact of maternal psychotropic use or abuse on late pregnancy in newborns, using data from hospital laboratory (positive assay for psychoactive drugs). Fifty three newborns were included between 1998 and 2002. Most of cases have been exposed to benzodiazepines, opioids and cannabis. Ninety two and a half per cent had a neonatal disease. Neonatal withdrawal, respiratory disease, hypotonia and hypotrophy were the most frequent neonatal pathologies. Many cases were exposed to cannabis which might increase neonatal disease risk. These results underline the impact of psychotropic use or abuse during pregnancy on neonatal outcomes.
Lacroix
Isabelle
I
Service de Pharmacologie Clinique, Unité médicaments, grossesse et allaitement, EA3696 - IFR 126 Santé-Société, 37 allées Jules Guesde, 31000 Toulouse, France. lacroix@cict.fr
Hurault
Caroline
C
Saivin
Sylvie
S
Raoul
Valérie
V
Berrebi
Alain
A
Souchet
Emmanuelle
E
Desboeuf
Karine
K
Montastruc
Jean-Louis
JL
Damase-Michel
Christine
C
D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000139:chemically induced / Q000453:epidemiology; D018811:Maternal Exposure; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011619:Psychotropic Drugs / Q000009:adverse effects*; D012189:Retrospective Studies
D011619:Psychotropic Drugs