title: Association between the G1246A polymorphism of the hypocretin receptor 2 gene and cluster headache: a meta-analysis.
abstract: The objective of this study was to investigate the association between polymorphisms of the hypocretin receptor 2 gene (HCRTR2) and the risk of cluster headache (CH). The study is a meta-analysis of published case-control studies investigating the association between polymorphisms of the HCRTR2 gene and CH. Pooled odds ratios (OR) were estimated using both random (RE) and fixed effects (FE) models. Three studies, performed in five different European countries, with 593 cases and 599 controls, were included in the study. Allele G of the G1246A HCRTR2 polymorphism was significantly associated with CH (FE OR 1.58, CI 95% 1.27-1.95; RE OR 1.55 (1.14-2.12)). Carriers of the GG genotype showed a higher disease risk compared to the remaining genotypes (FE OR 1.75, CI 95% 1.37-2.25; RE OR 1.69, CI 95% 1.11-2.58). Our data confirm that the G1246A polymorphism of the HCRTR2 gene may modulate the genetic risk for CH.
authors.affiliation: Neurology II-Headache Centre, Department of Neuroscience, University of Turin, Via Cherasco 15, I-10126 Turin, Italy. irainero@molinette.piemonte.it
authors.forename: Innocenzo
authors.initials: I
authors.lastname: Rainero
authors.forename: Elisa
authors.initials: E
authors.lastname: Rubino
authors.forename: Walter
authors.initials: W
authors.lastname: Valfrè
authors.forename: Salvatore
authors.initials: S
authors.lastname: Gallone
authors.forename: Paola
authors.initials: P
authors.lastname: De Martino
authors.forename: Erika
authors.initials: E
authors.lastname: Zampella
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Pinessi
mesh_terms: D000483:Alleles; D016022:Case-Control Studies; D003027:Cluster Headache / Q000453:epidemiology / Q000235:genetics*; D005060:Europe / Q000453:epidemiology; D005787:Gene Frequency; D006801:Humans; D015233:Models, Statistical; D016017:Odds Ratio; D064446:Orexin Receptors; D011110:Polymorphism, Genetic / Q000235:genetics*; D043562:Receptors, G-Protein-Coupled / Q000235:genetics*; D018013:Receptors, Neuropeptide / Q000235:genetics*; D012306:Risk
chemical_list: D064446:Orexin Receptors; D043562:Receptors, G-Protein-Coupled; D018013:Receptors, Neuropeptide