title: Review of clinical trials of skin antiseptic agents used to reduce blood culture contamination.
abstract: False-positive blood culture results may lead to prolonged hospitalization, inappropriate antibiotic administration, and increased healthcare costs. We conducted a review of the literature to assess the effect of skin antiseptic agents on the rate of false-positive blood culture results. We found no clear evidence to suggest which antiseptic should be used to prevent false-positive results. Studies suggest, however, a possible benefit from the use of prepackaged skin antiseptic kits and alcohol-containing antiseptics.
authors.affiliation: Division of Infectious Diseases, University of Michigan Medical School, Ann Arbor, MI, USA. malanian@med.umich.edu
authors.forename: Anurag
authors.initials: A
authors.lastname: Malani
authors.forename: Kim
authors.initials: K
authors.lastname: Trimble
authors.forename: Vikas
authors.initials: V
authors.lastname: Parekh
authors.forename: Carol
authors.initials: C
authors.lastname: Chenoweth
authors.forename: Samuel
authors.initials: S
authors.lastname: Kaufman
authors.forename: Sanjay
authors.initials: S
authors.lastname: Saint
mesh_terms: D019840:2-Propanol / Q000008:administration & dosage; D000287:Administration, Topical; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage*; D001769:Blood / Q000382:microbiology*; D002710:Chlorhexidine / Q000008:administration & dosage; D002986:Clinical Trials as Topic; D005189:False Positive Reactions; D006801:Humans; D007455:Iodine / Q000008:administration & dosage; D011206:Povidone-Iodine / Q000008:administration & dosage; D012867:Skin / Q000187:drug effects / Q000382:microbiology*
chemical_list: D000891:Anti-Infective Agents, Local; D011206:Povidone-Iodine; D007455:Iodine; D019840:2-Propanol; D002710:Chlorhexidine