title: Synthesis of diverse lactam carboxamides leading to the discovery of a new transcription-factor inhibitor.
authors.affiliation: The Broad Institute of Harvard and MIT, 7 Cambridge Center, Cambridge, MA 02142, USA.
authors.forename: Pui Yee
authors.initials: PY
authors.lastname: Ng
authors.forename: Yuchen
authors.initials: Y
authors.lastname: Tang
authors.forename: Wendy M
authors.initials: WM
authors.lastname: Knosp
authors.forename: H Scott
authors.initials: HS
authors.lastname: Stadler
authors.forename: Jared T
authors.initials: JT
authors.lastname: Shaw
mesh_terms: D000577:Amides / Q000138:chemical synthesis / Q000737:chemistry*; D002264:Carboxylic Acids / Q000737:chemistry*; D004247:DNA / Q000737:chemistry / Q000378:metabolism; D018398:Homeodomain Proteins / Q000737:chemistry / Q000378:metabolism; D007769:Lactams / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D013237:Stereoisomerism; D014157:Transcription Factors / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: D000577:Amides; D002264:Carboxylic Acids; D018398:Homeodomain Proteins; D007769:Lactams; D014157:Transcription Factors; C099959:homeobox protein HOXA13; D004247:DNA