Regulation of anchor cell invasion and uterine cell fates by the egl-43 Evi-1 proto-oncogene in Caenorhabditis elegans.
Cell invasion is a tightly controlled process occurring during development and tumor progression. The nematode Caenorhabditis elegans serves as a genetic model to study cell invasion during normal development. In the third larval stage, the anchor cell in the somatic gonad first induces and then invades the adjacent epidermal vulval precursor cells. The homolog of the Evi-1 oncogene, egl-43, is necessary for basement membrane destruction and anchor cell invasion. egl-43 is part of a regulatory network mediating cell invasion downstream of the fos-1 proto-oncogene. In addition, EGL-43 is required to specify the cell fates of ventral uterus cells downstream of or in parallel with LIN-12 NOTCH. Comparison with mammalian Evi-1 suggests a conserved pathway controlling cell invasion and cell fate specification.
Rimann
Ivo
I
Institute of Zoology, University of Zürich, Winterthurerstr. 190, CH-8057 Zürich, Switzerland.
Hajnal
Alex
A
D000818:Animals; D030801:Animals, Genetically Modified; D015820:Cadherins / Q000235:genetics / Q000378:metabolism; D017173:Caenorhabditis elegans / Q000166:cytology / Q000235:genetics* / Q000254:growth & development* / Q000378:metabolism; D029742:Caenorhabditis elegans Proteins / Q000235:genetics* / Q000378:metabolism; D005260:Female; D018507:Gene Expression Regulation, Developmental; D017238:Genes, Helminth; D008954:Models, Biological; D016760:Proto-Oncogene Proteins c-fos / Q000235:genetics / Q000378:metabolism; D011519:Proto-Oncogenes; D034622:RNA Interference; D014157:Transcription Factors / Q000235:genetics* / Q000378:metabolism; D014599:Uterus / Q000166:cytology / Q000254:growth & development / Q000378:metabolism
C103967:CDH-3 protein, C elegans; D015820:Cadherins; D029742:Caenorhabditis elegans Proteins; C084226:Egl-43 protein, C elegans; C520083:FOS-1 protein, C elegans; D016760:Proto-Oncogene Proteins c-fos; D014157:Transcription Factors