[Identification and application of marker genes for differential diagnosis of chronic fatigue syndrome].
Chronic fatigue syndrome (CFS) is a complex disease and has no laboratory biomarkers, which makes diagnosis of CFS difficult. Several research groups challenged to identify genes specific for CFS; however, there are no overlaps between studies. The U.S. Centers for Disease Control and Prevention reported remarkable gene expression profiles of a large scale cohort study recruited 227 people. Reported genes were mostly different from the previously reported genes, again featuring the complexity of CFS. Separately, we identified 9 genes that were significantly and differentially expressed between CFS patients and healthy subjects using an original microarray. The changes in expression of 9 genes were confirmed by quantitative PCR. We also demonstrated the usefulness of 9 genes for differential diagnosis of CFS.
Kawai
Tomoko
T
Department of Stress Science, Institute of Health Biosciences, The University of Tokushima Graduate School.
Rokutan
Kazuhito
K
D003937:Diagnosis, Differential; D015673:Fatigue Syndrome, Chronic / Q000175:diagnosis* / Q000235:genetics*; D005819:Genetic Markers; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis
D005819:Genetic Markers