Experimental (13C NMR) and theoretical (ab initio molecular orbital calculations) studies on the prototropic tautomerism of benzotriazole and some derivatives symmetrically substituted on the benzene ring.
The prototropic tautomerism in anhydrous DMSO of benzotriazole and six derivatives symmetrically substituted on the benzene ring (5,6-dichloro, tetrachloro, 4,7-dibromo, tetrabromo, 5,6-dimethyl, and tetramethyl), was followed by both experimental (13C NMR and UV spectroscopy) and theoretical methods. In all of the analyzed systems, predominance of the asymmetric form, N(1)/N(3) protonated, was found. The rates of the N(1)-H<-->N(3)-H prototropic equilibrium, estimated by 13C NMR techniques, were in the medium exchange regime of 300-3000 s(-1), and are correlated with the spectroscopically determined pKa values in aqueous medium, and the anionic forms are the putative rate-limiting intermediate states.
Poznański
Jarosław
J
Institute of Biochemistry and Biophysics, Polish Academy of Sciences, 5a Pawińskiego St. 02-106 Warszawa, Poland. jarek@ibb.waw.pl
Najda
Andzelika
A
Bretner
Maria
M
Shugar
David
D
D001555:Benzene Derivatives / Q000737:chemistry*; D002247:Carbon Isotopes; D009682:Magnetic Resonance Spectroscopy; D008956:Models, Chemical; D015394:Molecular Structure; D013237:Stereoisomerism; D013816:Thermodynamics; D014230:Triazoles / Q000737:chemistry*
D001555:Benzene Derivatives; D002247:Carbon Isotopes; D014230:Triazoles; C012771:benzotriazole