Neuroprotective evaluation of standardized extract of Centella asciatica in monosodium glutamate treated rats.
The effect of chloroform: methanolic (80:20) extract of C. asiatica (CA; 100 and 200 mg/kg), was evaluated on the course of free radical generation and excitotoxicity in monosodiumglutamate (MSG) treated female Sprague Dawley rats. The extract showed significant improvement in catalase, super oxide desmutase and lipid peroxides levels in hippocampus and striatum regions. Glutathione level was not altered with CA treatment. Similar observation was made with dextromethorphan. The general behavior, locomotor activity and CAl a region of the hippocampus was significantly protected by CA indicating neuroprotective effect of CA in MSG induced excitotoxic condition. Hence it can be concluded that CA protected MSG induced neurodegeneration attributed to its antioxidant and behavioural properties. This activity of CA can be explored in epilepsy, stroke and other degenerative conditions in which the role of glutamate is known to play vital role in the pathogenesis.
Ramanathan
M
M
Neuropharmacology Laboratory, Department of Pharmacology, J. S. S. College of Pharmacy, Ootacamund, 643 001, India. muthiahramanathanin@yahoo.co.in
Sivakumar
S
S
Anandvijayakumar
P R
PR
Saravanababu
C
C
Pandian
P Rathinavel
PR
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D002374:Catalase / Q000032:analysis; D028041:Centella / Q000737:chemistry; D003342:Corpus Striatum / Q000737:chemistry / Q000187:drug effects / Q000201:enzymology / Q000473:pathology; D005260:Female; D005978:Glutathione / Q000032:analysis; D006624:Hippocampus / Q000737:chemistry / Q000187:drug effects / Q000201:enzymology / Q000473:pathology; D019636:Neurodegenerative Diseases / Q000139:chemically induced* / Q000473:pathology / Q000517:prevention & control*; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012970:Sodium Glutamate; D013482:Superoxide Dismutase / Q000032:analysis; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis
D018696:Neuroprotective Agents; D010936:Plant Extracts; D017392:Thiobarbituric Acid Reactive Substances; D002374:Catalase; D013482:Superoxide Dismutase; D005978:Glutathione; D012970:Sodium Glutamate