title: Treatment response in liver metastases following 90Y SIR-spheres: an evaluation with PET.
abstract: Selective internal radiation therapy (SIRT) with radiolabeled Yttrium-90 (90Y) microspheres is a relatively new therapeutic option for patients with primary or secondary hepatic malignancy. However, the evaluation of the therapeutic efficacy on anatomic imaging alone is suboptimal. Functional imaging with F18-2-fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET) is increasingly utilised in therapy monitoring in malignancy and provides an accurate assessment of metabolic response. We report a case of a 75-year-old gentleman with colorectal hepatic metastases who demonstrated a dramatic metabolic response on PET scan following SIRT. This case illustrates the utility of FDG PET in the assessment of the therapeutic efficacy of 90Y microspheres in colorectal hepatic metastases.
authors.affiliation: Department of Nuclear Medicine, PET and Clinical Ultrasound, Liverpool Hospital, 1 Elizabeth Drive, Liverpool, NSW 2170, Australia. michael.lin@swsahs.nsw.gov.au
authors.forename: Michael
authors.initials: M
authors.lastname: Lin
authors.forename: Ivan Ho
authors.initials: IH
authors.lastname: Shon
authors.forename: Robert
authors.initials: R
authors.lastname: Wilson
authors.forename: Scott K
authors.initials: SK
authors.lastname: D'Amours
authors.forename: Glenn
authors.initials: G
authors.lastname: Schlaphoff
authors.forename: Peter
authors.initials: P
authors.lastname: Lin
mesh_terms: D000368:Aged; D015179:Colorectal Neoplasms / Q000473:pathology; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008113:Liver Neoplasms / Q000000981:diagnostic imaging* / Q000532:radiotherapy* / Q000556:secondary; D008297:Male; D008863:Microspheres; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D016896:Treatment Outcome; D015021:Yttrium Radioisotopes / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D019275:Radiopharmaceuticals; D015021:Yttrium Radioisotopes; D019788:Fluorodeoxyglucose F18