title: Comparative genomics: a tool to functionally annotate human DNA.
abstract: The availability of an increasing number of vertebrate genomes has enabled comparative methods to infer functional sequences based on evolutionary constraint. Although this has proved powerful for gene identification, significant progress has also been made in uncovering gene regulatory sequences such as distant acting transcriptional enhancers. These pursuits have led to the development of a variety of valuable databases and resources that should serve as a routine toolbox for biological discovery.
authors.affiliation: Genomics Division, Lawrence Berkeley National Laboratory, CA, USA.
authors.forename: Jan-Fang
authors.initials: JF
authors.lastname: Cheng
authors.forename: James R
authors.initials: JR
authors.lastname: Priest
authors.forename: Len A
authors.initials: LA
authors.lastname: Pennacchio
mesh_terms: D000818:Animals; D001483:Base Sequence; D017124:Conserved Sequence; D004247:DNA / Q000235:genetics*; D019143:Evolution, Molecular; D015894:Genome, Human; D023281:Genomics / Q000379:methods*; D006801:Humans; D008969:Molecular Sequence Data; D010802:Phylogeny; D012045:Regulatory Sequences, Nucleic Acid; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA; D012689:Sequence Homology, Nucleic Acid
chemical_list: D004247:DNA