Hyperplastic polyposis associated with two asynchronous colon cancers.
We report a patient with hyperplastic polyposis who had two asynchronous colon cancers, a combined adenoma-hyperplastic polyp, a serrated adenoma, and tubular adenomas. Hyperplastic polyposis is thought to be a precancerous lesion; and adenocarcinoma arises from hyperplastic polyposis through the hyperplastic polyp-adenoma-carcinoma sequence. Most polyps in patients with hyperplastic polyposis present as bland-looking hyperplastic polyps, which are regarded as non-neoplastic lesions; however, the risk of malignancy should not be underestimated. In patients with multiple hyperplastic polyps, hyperplastic polyposis should be identified and followed up carefully in order to detect malignant transformation in the early stage.
Kurobe
Masaya
M
Department of Pathology, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan.
Abe
Kuniko
K
Kinoshita
Naoe
N
Anami
Masanobu
M
Tokai
Hirotaka
H
Ryu
Yoshinori
Y
Wen
Chun Yang
CY
Kanematsu
Takashi
T
Hayashi
Tomayoshi
T
D000230:Adenocarcinoma / Q000473:pathology*; D000236:Adenoma / Q000473:pathology*; D000368:Aged; D000369:Aged, 80 and over; D003110:Colonic Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D006965:Hyperplasia; D007417:Intestinal Polyps / Q000473:pathology*; D011230:Precancerous Conditions / Q000473:pathology*