[The influence of Spirulina and Selen-Spirulina on some indexes of rat's immune status].
This paper reviews evidence for the immune-enhancing effect of Spirulina (Sp) and Selen-Spirulina (Se-Sp) in male Wistar rats. The rats of control group fed half-synthetic diet. Rats of experimental groups consumed the half-synthetic diets with Sp (10 g/kg diet) or Se-Sp (350 microg Se/kg diet) for 2 weeks. Using rats lymphocytes in vitro after phytohemagglutinin stimulation was demonstrated that lymphocytes from Sp and Se-Sp groups secreted of interleukin-2 and interferon-gamma more control group. Induction of interleukin-4 was comparable with once of control group. We believed that Sp and Se-Sp are more effective in stimulating a Th-1--type response and hence potentiates cell-mediated immunity. The immunostimulatory effect of Sp and Se-Sp was confirmed by morphologic and morphometric investigation of rats spleen, also with by NBT-test of peritoneal macrophages.
Trushina
E N
EN
Gladkikh
Ol
O
Gadzhieva
Z M
ZM
Mustafina
O K
OK
Pozdniakov
A L
AL
D000818:Animals; D016207:Cytokines / Q000276:immunology*; D005503:Food Additives / Q000008:administration & dosage; D007111:Immunity, Cellular / Q000187:drug effects; D017737:Macrophages, Peritoneal / Q000276:immunology*; D008297:Male; D010835:Phytohemagglutinins / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D012643:Selenium / Q000008:administration & dosage / Q000276:immunology*; D053545:Spirulina / Q000276:immunology*; D013154:Spleen / Q000276:immunology; D018417:Th1 Cells / Q000276:immunology*
D016207:Cytokines; D005503:Food Additives; D010835:Phytohemagglutinins; D012643:Selenium