Antiviral and anti-inflammatory effects of rosmarinic acid in an experimental murine model of Japanese encephalitis.
Rosmarinic acid (RA) reduced the mortality of mice infected with Japanese encephalitis virus (JEV). Significant decreases in viral loads (P < 0.001) and proinflammatory cytokine levels (P < 0.001) were observed in JEV-infected animals treated with RA compared to levels in infected mice without treatment, at 8 to 9 days postinfection.
Swarup
Vivek
V
National Brain Research Centre, Manesar, Haryana-122050, India.
Ghosh
Joydeep
J
Ghosh
Soumya
S
Saxena
Amit
A
Basu
Anirban
A
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000998:Antiviral Agents; D015153:Blotting, Western; D018925:Chemokines / Q000378:metabolism; D002934:Cinnamates / Q000494:pharmacology*; D016207:Cytokines / Q000378:metabolism; D053630:Depsides / Q000494:pharmacology*; D004664:Encephalitis Virus, Japanese / Q000187:drug effects; D004672:Encephalitis, Japanese / Q000188:drug therapy* / Q000473:pathology / Q000821:virology*; D051379:Mice; D000097123:Rosmarinic Acid
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000998:Antiviral Agents; D018925:Chemokines; D002934:Cinnamates; D016207:Cytokines; D053630:Depsides; D000097123:Rosmarinic Acid