title: Carbohydrate-based macrolides prepared via a convergent ring closing metathesis approach: in search for novel antibiotics.
abstract: An efficient convergent approach has been developed for the construction of novel, nonnatural polysubstituted carbohydrate-based macrolides. A key step in the synthesis is the formation of the macrocyclic ring via a ring-closing metathesis reaction. The obtained macrolide analogues have been screened for biological activity against gram-positive and gram-negative bacteria, yeasts, and molds.
authors.affiliation: Laboratory for Organic and Bioorganic Synthesis, Department of Organic Chemistry, Ghent University, Krijgslaan 281 (S4), B-9000 Gent, Belgium.
authors.forename: Bart
authors.initials: B
authors.lastname: Ruttens
authors.forename: Petra
authors.initials: P
authors.lastname: Blom
authors.forename: Steven
authors.initials: S
authors.lastname: Van Hoof
authors.forename: Idzi
authors.initials: I
authors.lastname: Hubrecht
authors.forename: Johan
authors.initials: J
authors.lastname: Van der Eycken
authors.forename: Benedikt
authors.initials: B
authors.lastname: Sas
authors.forename: Johan
authors.initials: J
authors.lastname: Van Hemel
authors.forename: Jan
authors.initials: J
authors.lastname: Vandenkerckhove
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry; D002241:Carbohydrates / Q000737:chemistry*; D003500:Cyclization; D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D000900:Anti-Bacterial Agents; D002241:Carbohydrates; D018942:Macrolides