title: Obesity and immune cell counts in women.
abstract: Obesity is common in women and is associated with a number of adverse health outcomes including cardiovascular disease, infectious diseases, and cancer. We explore the relationship between obesity and immune cell counts in women in a longitudinal study of 322 women from 1999 through 2003 enrolled as HIV-negative comparators in the Women's Interagency HIV Study. Body mass index (BMI, kg/m(2)) was categorized as normal weight (BMI 18.5-24.9), overweight (BMI 25-29.9), obese (BMI 30-34.9), and morbidly obese (BMI >/=35). CD4 and CD8 counts and percents and total lymphocyte and white blood cell (WBC) counts were measured annually using standardized techniques. A mixed model repeated measures analysis was performed using an autoregressive correlation matrix. At the index visit, 61% of women were African American; mean age was 35 years, and median BMI was 29 kg/m(2). Immunologic parameters were in the reference range (median CD4 count, 995 cells/mm(3); CD8 count, 488 cells/mm(3); total lymphocyte count, 206 cells/mm(3); median WBC, 6 x 10(3) cells/mm(3)). In multivariate analyses, being overweight, obese, or morbidly obese were independently associated with higher CD4, total lymphocyte, and WBC counts than being normal weight; morbid obesity was associated with a higher CD8 count. The strongest associations between body weight and immune cell counts were demonstrated in the morbidly obese. Increasing body weight is associated with higher CD4, CD8, total lymphocyte, and WBC counts in women. Investigation into the impact of obesity on immune function and long-term adverse outcomes is needed.
authors.affiliation: Yale University School of Nursing, New Haven, CT 06536-0740, USA. julie.womack@yale.edu
authors.forename: Julie
authors.initials: J
authors.lastname: Womack
authors.forename: Phyllis C
authors.initials: PC
authors.lastname: Tien
authors.forename: Joseph
authors.initials: J
authors.lastname: Feldman
authors.forename: Ja Hyun
authors.initials: JH
authors.lastname: Shin
authors.forename: Kristopher
authors.initials: K
authors.lastname: Fennie
authors.forename: Kathryn
authors.initials: K
authors.lastname: Anastos
authors.forename: Mardge H
authors.initials: MH
authors.lastname: Cohen
authors.forename: Melanie C
authors.initials: MC
authors.lastname: Bacon
authors.forename: Howard
authors.initials: H
authors.lastname: Minkoff
mesh_terms: D015992:Body Mass Index; D018791:CD4 Lymphocyte Count; D016516:CD4-CD8 Ratio; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D018655:Lymphocyte Count; D009765:Obesity / Q000276:immunology*