Tagged phosphine reagents to assist reaction work-up by phase-switched scavenging using a modular flow reactor.
The use of three orthogonally tagged phosphine reagents to assist chemical work-up via phase-switch scavenging in conjunction with a modular flow reactor is described. These techniques (acidic, basic and Click chemistry) are used to prepare various amides and tri-substituted guanidines from in situ generated iminophosphoranes.
Smith
Christopher D
CD
Innovative Technology Centre (ACS), Department of Chemistry, Lensfield Road, Cambridge, UKCB2 1EW.
Baxendale
Ian R
IR
Tranmer
Geoffrey K
GK
Baumann
Marcus
M
Smith
Stephen C
SC
Lewthwaite
Russell A
RA
Ley
Steven V
SV