Targeting the brain: rationalizing the novel methods of drug delivery to the central nervous system.
Drug delivery to the brain has remained one of the most vexing problems in translational neuroscience research. This review rationalizes the strategies to target drugs to the brain. Factors such as the speed of intervention, the scale of intervention, the state of BBB, and the permissible risks, will all be critical in deciding how best to deliver drugs to a target site in the brain for a specific clinical situation.
Joshi
Shailendra
S
Department of Anesthesiology, College of Physicians and Surgeons of Columbia University, 630 West 168th Street, P&S Box 46, New York, NY 10032, USA. sj121@columbia.edu
Ornstein
Eugene
E
Bruce
Jeffrey N
JN
D001812:Blood-Brain Barrier; D001921:Brain; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D012307:Risk Factors; D013997:Time Factors