title: Thoracic spinal cord compression indicating Wegener's granulomatosis in a patient with a previous presumptive diagnosis of microscopic polyangiitis.
abstract: Neurological signs are observed in 20-50% of cases of Wegener's granulomatosis consisting of peripheral and cranial neuropathy, and central nervous system involvement during the disease and rarely as initial symptom. We report here a case of thoracic spinal cord compression due to dural masses in a patient with a previous presumptive diagnosis of microscopic polyangiitis indicating Wegener's granulomatosis on histological examination. No other site of involvement was found. Slight clinical improvement was observed under immunosuppressive treatment probably because of spinal cord vessels lesions.
authors.affiliation: Service de Médecine Interne, CHU Tenon (AP-HP), 4 rue de la Chine, 75020 Paris, France. claude.bachmeyer@tnn.aphp.fr
authors.forename: Claude
authors.initials: C
authors.lastname: Bachmeyer
authors.forename: Pascale
authors.initials: P
authors.lastname: Cervera
authors.forename: Béatrice
authors.initials: B
authors.lastname: Marro
authors.forename: Wafa
authors.initials: W
authors.lastname: Ammouri
authors.forename: Eric
authors.initials: E
authors.lastname: Bouvard
authors.forename: Pascal
authors.initials: P
authors.lastname: Favrole
authors.forename: Frédéric
authors.initials: F
authors.lastname: Jacquot
authors.forename: Gilles
authors.initials: G
authors.lastname: Grateau
mesh_terms: D000368:Aged; D001707:Biopsy, Needle; D003520:Cyclophosphamide / Q000008:administration & dosage; D003937:Diagnosis, Differential; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D014890:Granulomatosis with Polyangiitis / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D008775:Methylprednisolone / Q000008:administration & dosage; D018570:Risk Assessment; D013117:Spinal Cord Compression / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D013904:Thoracic Vertebrae; D016896:Treatment Outcome; D014657:Vasculitis / Q000175:diagnosis*
chemical_list: D003520:Cyclophosphamide; D008775:Methylprednisolone