title: Micelles of different morphologies--advantages of worm-like filomicelles of PEO-PCL in paclitaxel delivery.
abstract: OBJECTIVE
  Worm-like and spherical micelles are both prepared here from the same amphiphilic diblock copolymer, poly(ethylene oxide)-b-poly (epsilon-caprolactone) (PEO [5 kDa]-PCL [6.5 kDa]) in order to compare loading and delivery of hydrophobic drugs.
  
  
  METHODS
  Worm-like micelles of this degradable copolymer are nanometers in cross-section and spontaneously assemble to stable lengths of microns, resembling filoviruses in some respects and thus suggesting the moniker 'filomicelles'. The highly flexible worm-like micelles can also be sonicated to generate kinetically stable spherical micelles composed of the same copolymer.
  
  
  RESULTS
  The fission process exploits the finding that the PCL cores are fluid, rather than glassy or crystalline, and core-loading of the hydrophobic anticancer drug delivery, paclitaxel (TAX) shows that the worm-like micelles load and solubilize twice as much drug as spherical micelles. In cytotoxicity tests that compare to the clinically prevalent solubilizer, Cremophor EL, both micellar carriers are far less toxic, and both types of TAX-loaded micelles also show fivefold greater anticancer activity on A549 human lung cancer cells.
  
  
  CONCLUSIONS
  PEO-PCL based worm-like filomicelles appear to be promising pharmaceutical nanocarriers with improved solubilization efficiency and comparable stability to spherical micelles, as well as better safety and efficacy in vitro compared to the prevalent Cremophor EL TAX formulation.
authors.affiliation: Department of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
authors.forename: Shenshen
authors.initials: S
authors.lastname: Cai
authors.forename: Kandaswamy
authors.initials: K
authors.lastname: Vijayan
authors.forename: Debbie
authors.initials: D
authors.lastname: Cheng
authors.forename: Eliana M
authors.initials: EM
authors.lastname: Lima
authors.forename: Dennis E
authors.initials: DE
authors.lastname: Discher
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage*; D045744:Cell Line, Tumor; D016503:Drug Delivery Systems; D004355:Drug Stability; D006801:Humans; D008823:Micelles; D017239:Paclitaxel / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology; D011091:Polyesters / Q000008:administration & dosage*; D012995:Solubility
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D008823:Micelles; D011091:Polyesters; C458722:polyethylene oxide-polycaprolactone copolymer; D017239:Paclitaxel