Cyclin A expression and its diagnostic value in pleomorphic adenoma and carcinoma expleomorphic adenoma of the parotid gland.
OBJECTIVE
To investigate cyclin A expression in pleomorphic adenoma (PA) and carcinoma expleomorphic adenoma (CXPA) of the parotid gland with a view to assessing its potential value as a diagnostic marker for CXPA.


RESULTS
Cyclin A expression in PA and CXPA was studied using semiquantitative immunohistochemistry. The epithelial component of the tumours expressed cyclin A in a statistically significantly (P < 0.005) higher number of CXPA cases (86%) compared with the PA cases (39%). Cyclin A was not expressed in normal salivary tissues of PA and CXPA.


CONCLUSIONS
High cyclin A expression is a useful marker for the pathological diagnosis of CXPA.
Patel
R S
RS
Sydney Head & Neck Cancer Institute, Sydney Cancer Centre, University of Sydney, Sydney, New South Wales, Australia. dr_rajan_patel@hotmail.com
Hughes
C W
CW
Fredericks
S
S
Lee
C S
CS
Rose
B
B
Gao
K
K
Smith
G
G
Hong
A
A
O'Brien
C J
CJ
D008949:Adenoma, Pleomorphic / Q000175:diagnosis* / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000378:metabolism; D016022:Case-Control Studies; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D019925:Cyclin A / Q000235:genetics / Q000378:metabolism*; D003937:Diagnosis, Differential; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D010306:Parotid Gland / Q000378:metabolism / Q000473:pathology; D010307:Parotid Neoplasms / Q000175:diagnosis* / Q000378:metabolism*
D014408:Biomarkers, Tumor; D019925:Cyclin A