title: The Candida albicans gene HGT12 (orf19.7094) encodes a hexose transporter.
abstract: Yeast cells of the human pathogen Candida albicans that enter the bloodstream can be engulfed by macrophage cells but survive in, and can escape from, the phagolysosome. The C. albicans gene HGT12, which is specifically expressed during macrophage infection, encodes a protein that transports fructose, glucose and mannose. Expression of this hexose transporter along with the shift from glycolysis to gluconeogenesis that occurs in these phagocytosed cells suggests a requirement for glucose that can be supplied in part by uptake from the lumen of the phagolysosome.
authors.affiliation: Institute of Molecular Biosciences, Massey University, New Zealand.
authors.forename: Lin
authors.initials: L
authors.lastname: Luo
authors.forename: XingZhang
authors.initials: X
authors.lastname: Tong
authors.forename: Peter C
authors.initials: PC
authors.lastname: Farley
mesh_terms: D002176:Candida albicans / Q000235:genetics*; D005800:Genes, Fungal; D005947:Glucose / Q000378:metabolism; D008264:Macrophages / Q000378:metabolism; D009004:Monosaccharide Transport Proteins / Q000235:genetics* / Q000502:physiology*; D010588:Phagosomes / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000378:metabolism
chemical_list: D009004:Monosaccharide Transport Proteins; D005947:Glucose