NADPH oxidases: new players in TNF-induced necrotic cell death.
Necrosis is a caspase-independent cell death process involving the generation of reactive oxygen species (ROS). In a recent issue of Molecular Cell, Kim et al. (2007) reported on a novel TNF receptor 1 necrotic signaling complex inducing TRADD- and RIP1-dependent recruitment and activation of the ROS-generating Nox1 NADPH oxidase complex.
Vanden Berghe
Tom
T
Department for Molecular Biomedical Research, VIB, Technologiepark 927, B-9052, Ghent, Belgium.
Declercq
Wim
W
Vandenabeele
Peter
P
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D002083:Butylated Hydroxyanisole / Q000494:pharmacology; D002460:Cell Line; D020690:GTPase-Activating Proteins / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D051379:Mice; D046912:Multiprotein Complexes / Q000378:metabolism; D019255:NADPH Oxidases / Q000378:metabolism*; D009336:Necrosis / Q000378:metabolism*; D009479:Neuropeptides / Q000737:chemistry / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects; D013481:Superoxides / Q000378:metabolism*; D053199:TNF Receptor-Associated Death Domain Protein / Q000737:chemistry / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism* / Q000494:pharmacology; D020744:rac GTP-Binding Proteins / Q000737:chemistry / Q000378:metabolism; D020830:rac1 GTP-Binding Protein
D000975:Antioxidants; D020690:GTPase-Activating Proteins; D046912:Multiprotein Complexes; D009479:Neuropeptides; C484602:Rac1 protein, mouse; C490620:Ralbp1 protein, mouse; D053199:TNF Receptor-Associated Death Domain Protein; C481226:Tradd protein, mouse; D014409:Tumor Necrosis Factor-alpha; D013481:Superoxides; D002083:Butylated Hydroxyanisole; D019255:NADPH Oxidases; D020744:rac GTP-Binding Proteins; D020830:rac1 GTP-Binding Protein