Design, synthesis, and molecular modeling studies of 5'-deoxy-5'-ureidoadenosine: 5'-ureido group as multiple hydrogen bonding donor in the active site of S-adenosylhomocysteine hydrolase.
5'-Deoxy-5'-ureidoadenosine was designed and synthesized as a potent inhibitor of S-adenosylhomocysteine hydrolase (SAH), in which 5'-ureido group acted as multiple hydrogen bonding donor in binding with active site residues of SAH in the molecular modeling study.
Wang
Ting
T
Laboratory of Medicinal Chemistry, College of Pharmacy, Ewha Womans University, Seoul 120-750, Republic of Korea.
Lee
Hyun Joo
HJ
Tosh
Dilip K
DK
Kim
Hea Ok
HO
Pal
Shantanu
S
Choi
Sun
S
Lee
Yoonji
Y
Moon
Hyung Ryong
HR
Zhao
Long Xuan
LX
Lee
Kang Man
KM
Jeong
Lak Shin
LS
D043383:Adenosylhomocysteinase / Q000737:chemistry / Q000378:metabolism*; D001665:Binding Sites; D003839:Deoxyadenosines / Q000138:chemical synthesis / Q000737:chemistry*; D015195:Drug Design; D006860:Hydrogen Bonding; D008958:Models, Molecular; D015394:Molecular Structure; D013329:Structure-Activity Relationship
C524172:5'-deoxy-5'-ureidoadenosine; D003839:Deoxyadenosines; D043383:Adenosylhomocysteinase