title: Evolution of medical treatment for endometriosis: back to the roots?
abstract: Experimental evidence is accumulating to suggest that medicinal botanicals have anti-inflammatory and pain-alleviating properties and hold promise for treatment of endometriosis. Herein, we present a systematic review of clinical and experimental data on the use of medicinal herbs in the treatment of endometriosis. Although there is a general lack of evidence from clinical studies on the potential efficacy of medicinal herbs for the treatment of endometriosis-associated symptoms, our review highlights the anti-inflammatory and pain-alleviating mechanisms of action of herbal remedies. Medicinal herbs and their active components exhibit cytokine-suppressive, COX-2-inhibiting, antioxidant, sedative and pain-alleviating properties. Each of these mechanisms of action would be predicted to have salutary effects in endometriosis. Better understanding of the mechanisms of action, toxicity and herb-herb and herb-drug interactions permits the optimization of design and execution of complementary alternative medicine trials for endometriosis-associated pain. A potential benefit of herbal therapy is the likelihood of synergistic interactions within individual or combinations of plants. In this sense, phytotherapies may be analogous to nutraceuticals or whole food nutrition. We encourage the development of herbal analogues and establishment of special, simplified registration procedures for certain medicinal products, particularly herbal derivates with a long tradition of safe use.
authors.affiliation: Division of Gynecological Endocrinology and Reproductive Medicine, University of Vienna, 1090 Vienna, Austria. fwieser@emory.edu
authors.forename: Fritz
authors.initials: F
authors.lastname: Wieser
authors.forename: Misha
authors.initials: M
authors.lastname: Cohen
authors.forename: Andrew
authors.initials: A
authors.lastname: Gaeddert
authors.forename: Jie
authors.initials: J
authors.lastname: Yu
authors.forename: Carla
authors.initials: C
authors.lastname: Burks-Wicks
authors.forename: Sarah L
authors.initials: SL
authors.lastname: Berga
authors.forename: Robert N
authors.initials: RN
authors.lastname: Taylor
mesh_terms: D000818:Animals; D004715:Endometriosis / Q000188:drug therapy*; D005260:Female; D041743:Herb-Drug Interactions; D006801:Humans; D051379:Mice; D008517:Phytotherapy; D028321:Plant Preparations / Q000627:therapeutic use*; D010946:Plants, Medicinal / Q000737:chemistry*
chemical_list: D028321:Plant Preparations