title: Effects of scaling and root planing and sub-antimicrobial dose doxycycline on oral and systemic biomarkers of disease in patients with both chronic periodontitis and coronary artery disease.
abstract: OBJECTIVE
  This study evaluated the effects of scaling and root planing (SRP) +/- sub-antimicrobial dose doxycycline (SDD) on gingival crevicular fluid (GCF) levels of matrix metalloproteinase (MMP) -1, -8, -13 and on serum levels of high-sensitivity C-reactive protein (HsCRP) and lipid fractions in patients with both chronic periodontitis (CP) and coronary artery disease (CAD).
  
  
  METHODS
  Thirty-six patients were randomly distributed into two groups (Placebo or SDD; 6 weeks) and both received two regimens of SRP. At baseline and 6 weeks, GCF and blood were collected and clinical indices were recorded. MMPs, HsCRP and lipid fractions were assayed.
  
  
  RESULTS
  There were statistically significant improvements for all clinical parameters, GCF volumes, GCF MMPs and serum levels of HsCRP, apolipoprotein-A (APO-A), high-density lipoprotein (HDL) and lipoprotein-a between pre- and post-treatment in both groups. Between groups, there were statistically significant greater improvements in pocket depth (PD), gingival index (GI), APO-A and HDL, favouring the group receiving SDD adjunctive to SRP (p < 0.05).
  
  
  CONCLUSIONS
  Greater improvement was detected for PD and GI, and for serum levels of APO-A and HDL cholesterol when using SRP+SDD compared with SRP+placebo in this study. An investigation with larger numbers of patients and a longer duration of drug treatment is needed to confirm these preliminary findings.
authors.affiliation: Department of Periodontology, Faculty of Dentistry, Gazi University, Ankara, Turkiye. gulay@gazi.edu.tr
authors.forename: Gülay
authors.initials: G
authors.lastname: Tüter
authors.forename: Bülent
authors.initials: B
authors.lastname: Kurtiş
authors.forename: Muhittin
authors.initials: M
authors.lastname: Serdar
authors.forename: Tuba
authors.initials: T
authors.lastname: Aykan
authors.forename: Kaan
authors.initials: K
authors.lastname: Okyay
authors.forename: Ayşegül
authors.initials: A
authors.lastname: Yücel
authors.forename: Utku
authors.initials: U
authors.lastname: Toyman
authors.forename: Selin
authors.initials: S
authors.lastname: Pinar
authors.forename: Mustafa
authors.initials: M
authors.lastname: Cemri
authors.forename: Atiye
authors.initials: A
authors.lastname: Cengel
authors.forename: Stephen G
authors.initials: SG
authors.lastname: Walker
authors.forename: Lorne M
authors.initials: LM
authors.lastname: Golub
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis / Q000187:drug effects; D002908:Chronic Disease; D003324:Coronary Artery Disease / Q000150:complications / Q000201:enzymology*; D012534:Dental Scaling; D004318:Doxycycline / Q000008:administration & dosage*; D004812:Epidemiologic Methods; D005260:Female; D005883:Gingival Crevicular Fluid / Q000201:enzymology; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D020781:Matrix Metalloproteinase 1 / Q000032:analysis / Q000187:drug effects*; D008875:Middle Aged; D010518:Periodontitis / Q000150:complications / Q000201:enzymology*; D016745:Root Planing
chemical_list: D000900:Anti-Bacterial Agents; D015415:Biomarkers; D008055:Lipids; D002097:C-Reactive Protein; D020781:Matrix Metalloproteinase 1; D004318:Doxycycline