title: Hyperplastic polyposis associated with two asynchronous colon cancers.
abstract: We report a patient with hyperplastic polyposis who had two asynchronous colon cancers, a combined adenoma-hyperplastic polyp, a serrated adenoma, and tubular adenomas. Hyperplastic polyposis is thought to be a precancerous lesion; and adenocarcinoma arises from hyperplastic polyposis through the hyperplastic polyp-adenoma-carcinoma sequence. Most polyps in patients with hyperplastic polyposis present as bland-looking hyperplastic polyps, which are regarded as non-neoplastic lesions; however, the risk of malignancy should not be underestimated. In patients with multiple hyperplastic polyps, hyperplastic polyposis should be identified and followed up carefully in order to detect malignant transformation in the early stage.
authors.affiliation: Department of Pathology, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan.
authors.forename: Masaya
authors.initials: M
authors.lastname: Kurobe
authors.forename: Kuniko
authors.initials: K
authors.lastname: Abe
authors.forename: Naoe
authors.initials: N
authors.lastname: Kinoshita
authors.forename: Masanobu
authors.initials: M
authors.lastname: Anami
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Tokai
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Ryu
authors.forename: Chun Yang
authors.initials: CY
authors.lastname: Wen
authors.forename: Takashi
authors.initials: T
authors.lastname: Kanematsu
authors.forename: Tomayoshi
authors.initials: T
authors.lastname: Hayashi
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D000236:Adenoma / Q000473:pathology*; D000368:Aged; D000369:Aged, 80 and over; D003110:Colonic Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D006965:Hyperplasia; D007417:Intestinal Polyps / Q000473:pathology*; D011230:Precancerous Conditions / Q000473:pathology*