title: Phosphonated carbocyclic 2'-oxa-3'-azanucleosides as new antiretroviral agents.
abstract: Phosphonated carbocyclic 2'-oxa-3'-azanucleosides have been synthesized and tested for their antiretroviral activity. The obtained results have shown that some of the compounds were as powerful as azydothymidine in inhibiting the reverse transcriptase activity of the human retrovirus T-cell leukemia/lymphotropic virus type 1 and in protecting human peripheral blood mononuclear cells against human retrovirus T-cell leukemia/lymphotropic virus type 1 transmission in vitro. These data indicate that phosphonated carbocyclic 2'-oxa-3'-azanucleosides possess the necessary requirements to efficiently counteract infections caused by human retroviruses.
authors.affiliation: Dipartimento di Scienze Chimiche, Università di Catania, Viale Andrea Doria 6, Catania 95125, Italy.
authors.forename: Ugo
authors.initials: U
authors.lastname: Chiacchio
authors.forename: Antonio
authors.initials: A
authors.lastname: Rescifina
authors.forename: Daniela
authors.initials: D
authors.lastname: Iannazzo
authors.forename: Anna
authors.initials: A
authors.lastname: Piperno
authors.forename: Roberto
authors.initials: R
authors.lastname: Romeo
authors.forename: Luisa
authors.initials: L
authors.lastname: Borrello
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: Sciortino
authors.forename: Emanuela
authors.initials: E
authors.lastname: Balestrieri
authors.forename: Beatrice
authors.initials: B
authors.lastname: Macchi
authors.forename: Antonio
authors.initials: A
authors.lastname: Mastino
authors.forename: Giovanni
authors.initials: G
authors.lastname: Romeo
mesh_terms: D044966:Anti-Retroviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001372:Aza Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015368:Human T-lymphotropic virus 1 / Q000187:drug effects* / Q000201:enzymology / Q000472:pathogenicity; D006801:Humans; D066298:In Vitro Techniques; D007963:Leukocytes, Mononuclear / Q000187:drug effects / Q000821:virology; D063065:Organophosphonates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011684:Purine Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011741:Pyrimidine Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D018894:Reverse Transcriptase Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D044966:Anti-Retroviral Agents; D001372:Aza Compounds; D063065:Organophosphonates; D011684:Purine Nucleosides; D011741:Pyrimidine Nucleosides; D018894:Reverse Transcriptase Inhibitors