Cytotoxic clerodane diterpenoids from fruits of Casearia grewiifolia.
Bioactivity-guided fractionation of the ethyl acetate-soluble fraction of a methanol extract of the fruits of Casearia grewiifolia afforded eight new clerodane diterpenes, caseargrewiins E-L (1-8), and a known clerodane diterpene, esculentin B (9). The structures of 1-8 were established on the basis of 1D and 2D NMR spectroscopic data. Most of these compounds exhibited cytotoxicity against three cancer cell lines with IC50 values in the range 0.15-6.00 microg/mL.
Kanokmedhakul
Somdej
S
Department of Chemistry, Applied Taxonomic Research Center, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand. somdej@kku.ac.th
Kanokmedhakul
Kwanjai
K
Buayairaksa
Mongkol
M
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D037821:Casearia / Q000737:chemistry*; D045785:Diterpenes, Clerodane / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005638:Fruit / Q000737:chemistry; D006801:Humans; D007624:KB Cells; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010946:Plants, Medicinal / Q000737:chemistry*; D013785:Thailand
D000972:Antineoplastic Agents, Phytogenic; D045785:Diterpenes, Clerodane