title: Gamma Knife surgery for adrenocorticotropic hormone-producing pituitary adenomas after bilateral adrenalectomy.
abstract: OBJECTIVE
  Patients with adrenocorticotropic hormone (ACTH)-secreting pituitary adenomas may require a bilateral adrenalectomy to treat their Cushing's disease. Approximately one third of these patients, however, will experience progressive enlargement of the residual pituitary adenoma, develop hyperpigmentation, and have an elevated level of serum ACTH. These patients with Nelson's syndrome can be treated with Gamma Knife surgery (GKS).
  
  
  METHODS
  The prospectively collected University of Virginia Gamma Knife database of patients with pituitary adenomas was reviewed to identify all individuals with Nelson's syndrome who were treated with GKS. Twenty-three patients with a minimum of 6 months of follow up were identified in the database. These patients were assessed for tumor control (that is, lack of tumor growth over time) with neuroimaging studies (median follow-up duration 22 months) and for biochemical normalization of their ACTH levels (median follow-up duration 50 months). Neuroimaging follow-up studies were available for 22 patients, and endocrine follow up was available for 15 patients in whom elevation of ACTH levels was documented prior to GKS. In the 22 patients in whom neuroimaging follow-up studies were available, 12 had a decrease in tumor size, eight had no tumor growth, and two had an increase in tumor volume. Ten of 15 patients with elevated ACTH levels prior to GKS showed a decrease in their ACTH levels at last follow up; three of these 10 patients achieved normal ACTH levels (< 50 pg/ml) and the other five patients with initially elevated values had an increase in ACTH levels. Ten patients were thoroughly evaluated for post-GKS pituitary function; four were found to have new pituitary hormone deficiency and six did not have hypopituitarism after GKS. One patient suffered a permanent third cranial nerve palsy and four patients are now deceased.
  
  
  CONCLUSIONS
  Gamma Knife surgery may control the residual pituitary adenoma and decrease ACTH levels in patients with Nelson's syndrome. Delayed hypopituitarism or cranial nerve palsies can occur after GKS. Patients with Nelson's syndrome require continued multidisciplinary follow-up care. Given the difficulties associated with management of Nelson's syndrome, even the modest results of GKS may be helpful for a number of patients.
authors.affiliation: Lars Leksell Gamma Knife Center, University of Virginia Health System, Charlottesville, Virginia, USA.
authors.forename: William J
authors.initials: WJ
authors.lastname: Mauermann
authors.forename: Jason P
authors.initials: JP
authors.lastname: Sheehan
authors.forename: Daniel R
authors.initials: DR
authors.lastname: Chernavvsky
authors.forename: Edward R
authors.initials: ER
authors.lastname: Laws
authors.forename: Ladislau
authors.initials: L
authors.lastname: Steiner
authors.forename: Mary Lee
authors.initials: ML
authors.lastname: Vance
mesh_terms: D049913:ACTH-Secreting Pituitary Adenoma / Q000473:pathology / Q000601:surgery*; D000236:Adenoma / Q000473:pathology / Q000601:surgery*; D000315:Adrenalectomy; D000324:Adrenocorticotropic Hormone / Q000097:blood; D002426:Cavernous Sinus / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D009347:Nelson Syndrome / Q000601:surgery*; D011183:Postoperative Complications / Q000453:epidemiology; D016634:Radiosurgery / Q000009:adverse effects; D012306:Risk; D014057:Tomography, X-Ray Computed
chemical_list: D000324:Adrenocorticotropic Hormone