title: Collection of Clonorchis sinensis adult worms from infected humans after praziquantel treatment.
abstract: A cohort was established for evaluation of cancer risk factors in Sancheong-gun, Gyeongsangnam-do, Korea. As one of the cohort studies, stools of 947 residents (403 males and 544 females, age range: 29-86 years) were screened for Clonorchis sinensis eggs using both Kato-Katz method and formalin-ether sedimentation technique. The overall egg positive rate of C. sinensis was 37.7% and individual EPG (eggs per gram of feces) counts ranged from 24 to 28,800. Eight egg positive residents voluntarily joined a process of collection of the passed worms after praziquantel treatment. A total of 158 worms were recovered from 5 of the 8 treated persons, ranged from 3 to 108 in each individual. The worms were 15-20 mm x 2-3 mm in size, and showed brown-pigmented, red, or white body colors. This is the first collection record of C. sinensis adult worms from humans through anthelmintic treatment and purgation. The adult worms of C. sinensis may be paralyzed by praziquantel and then discharged passively through bile flow in the bile duct and by peristaltic movement of the bowel.
authors.affiliation: Department of Parasitology and Tropical Medicine and Institute of Endemic Diseases, Seoul National University College of Medicine, Seoul 110-799, Korea.
authors.forename: Chenghua
authors.initials: C
authors.lastname: Shen
authors.forename: Jae hwan
authors.initials: Jh
authors.lastname: Kim
authors.forename: Jeong Keun
authors.initials: JK
authors.lastname: Lee
authors.forename: Young Mee
authors.initials: YM
authors.lastname: Bae
authors.forename: Min Ho
authors.initials: MH
authors.lastname: Choi
authors.forename: Jin Kyoung
authors.initials: JK
authors.lastname: Oh
authors.forename: Min Kyung
authors.initials: MK
authors.lastname: Lim
authors.forename: Hai Rim
authors.initials: HR
authors.lastname: Shin
authors.forename: Sung Tae
authors.initials: ST
authors.lastname: Hong
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D000980:Antiplatyhelmintic Agents / Q000627:therapeutic use*; D003003:Clonorchiasis / Q000188:drug therapy* / Q000453:epidemiology / Q000469:parasitology*; D003004:Clonorchis sinensis / Q000033:anatomy & histology / Q000302:isolation & purification*; D005243:Feces / Q000469:parasitology; D005260:Female; D006801:Humans; D007723:Korea / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000453:epidemiology; D010270:Parasite Egg Count; D011223:Praziquantel / Q000627:therapeutic use*; D012307:Risk Factors
chemical_list: D000980:Antiplatyhelmintic Agents; D011223:Praziquantel