Maternal serum interleukin-10, interleukin-2 and interleukin-6 in pre-eclampsia and eclampsia.
OBJECTIVE
The aim of the study was to investigate and compare the concentrations of interleukin (IL)-2, IL-6, and IL-10 in serum of women with mild pre-eclampsia, severe pre-eclampsia, eclampsia, and normotensive pregnancy.


METHODS
A total of 69 consecutive cases, 38 mild pre-eclampsia, 20 severe pre-eclampsia, 11 eclampsia, and 20 normotensive controls were included in this study. Serum IL-2, IL-6, and IL-10 levels were determined using enzyme-linked immunosorbent assay method.


RESULTS
Gestational age (P = 0.210) and body mass index (P = 0.214) between the groups were similar. The mean concentration of serum IL-2 and IL-6 were not different between the groups (P = 0.261, P = 0.141 respectively). The median concentrations of serum IL-10 in patients with mild and severe pre-eclampsia were similar (P < 0.282) and was significantly lower than those of controls (P < 0.001) and patients with eclampsia (P < 0.001). In patients with eclampsia, the median concentration of IL-10 was significantly higher than that of all other groups (P < 0.001 for each comparison).


CONCLUSIONS
Pre-eclampsia is associated with a deficiency serum IL-10. High serum IL-10 is correlated with the presence of eclampsia.
Borekci
Bunyamin
B
Department of Obstetrics and Gynecology, Ataturk University School of Medicine, Erzurum, Turkey. borekcib@gmail.com
Aksoy
Hulya
H
Al
Ragip Atakan
RA
Demircan
Berna
B
Kadanali
Sedat
S
D016022:Case-Control Studies; D016207:Cytokines / Q000097:blood*; D004461:Eclampsia / Q000097:blood* / Q000378:metabolism*; D005260:Female; D006801:Humans; D016753:Interleukin-10 / Q000097:blood; D007376:Interleukin-2 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D011225:Pre-Eclampsia / Q000097:blood* / Q000378:metabolism*; D011247:Pregnancy; D011446:Prospective Studies
D016207:Cytokines; D007376:Interleukin-2; D015850:Interleukin-6; D016753:Interleukin-10