title: Synthesis and SAR of novel conformationally-restricted oxazolidinones possessing gram-positive and fastidious gram-negative antibacterial activity. Part 1: Substituted pyrazoles.
abstract: A novel series of conformationally-restricted oxazolidinones was synthesized which possess a fused pyrazole ring substituted with various alkyl, aryl and heteroaryl substituents. A number of analogs exhibited potent activity against both gram-positive and fastidious gram-negative organisms.
authors.affiliation: Pfizer Global Research and Development, 2800 Plymouth Road, Ann Arbor, MI 48105, USA. FDBoyer@sbcglobal.net
authors.forename: Frederick E
authors.initials: FE
authors.lastname: Boyer
authors.forename: J V N
authors.initials: JV
authors.lastname: Vara Prasad
authors.forename: Allison L
authors.initials: AL
authors.lastname: Choy
authors.forename: Louis
authors.initials: L
authors.lastname: Chupak
authors.forename: Michael R
authors.initials: MR
authors.lastname: Dermyer
authors.forename: Qizhu
authors.initials: Q
authors.lastname: Ding
authors.forename: Michael D
authors.initials: MD
authors.lastname: Huband
authors.forename: Wenhua
authors.initials: W
authors.lastname: Jiao
authors.forename: Takushi
authors.initials: T
authors.lastname: Kaneko
authors.forename: Vladimir
authors.initials: V
authors.lastname: Khlebnikov
authors.forename: Ji-Young
authors.initials: JY
authors.lastname: Kim
authors.forename: Manjinder S
authors.initials: MS
authors.lastname: Lall
authors.forename: Samarendra N
authors.initials: SN
authors.lastname: Maiti
authors.forename: Karina
authors.initials: K
authors.lastname: Romero
authors.forename: Xiujuan
authors.initials: X
authors.lastname: Wu
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D015394:Molecular Structure; D023303:Oxazolidinones / Q000737:chemistry* / Q000494:pharmacology*; D011720:Pyrazoles / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D023303:Oxazolidinones; D011720:Pyrazoles