Human parvovirus 4 in the bone marrow of Italian patients with AIDS.
Human parvovirus 4 (PARV4) is a recently discovered member of the Parvoviridae. We investigated the presence of this virus in bone-marrow aspirates of 35 Italian patients with AIDS. Viral DNA was detected by polymerase chain reaction in over 40% of patients (16/35). The infection was most prevalent in injection drug users (IDU; 12/18; 66.7%) as opposed to non-IDU (4/17; 23.5%). PARV4 infection is widespread in Italian patients with AIDS.
Longhi
Erika
E
Department of Infectious Diseases, Luigi Sacco Hospital, Milan, Italy.
Bestetti
Giovanna
G
Acquaviva
Veronica
V
Foschi
Antonella
A
Piolini
Roberta
R
Meroni
Luca
L
Magni
Carlo
C
Antinori
Spinello
S
Parravicini
Carlo
C
Corbellino
Mario
M
D000163:Acquired Immunodeficiency Syndrome / Q000821:virology*; D000328:Adult; D001853:Bone Marrow / Q000821:virology*; D004279:DNA, Viral / Q000032:analysis*; D005260:Female; D005838:Genotype; D015497:HIV-1; D016174:Hepacivirus / Q000235:genetics; D006526:Hepatitis C / Q000821:virology; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D010321:Parvoviridae / Q000235:genetics*; D010322:Parvoviridae Infections / Q000821:virology*; D015995:Prevalence; D015819:Substance Abuse, Intravenous / Q000821:virology; D019562:Viral Load
D004279:DNA, Viral