title: De novo appearance of cerebellar cavernous malformation in a patient with moyamoya disease: case report and review of the literature.
abstract: The authors report a case of cerebellar cavernous malformation associated with moyamoya disease. An adolescent male with moyamoya disease had undergone bilateral direct and indirect extracranial-intracranial anastomosis at 11 years of age, and the course had been uneventful until MRI detected the appearance of a cavernous malformation in the cerebellum 3 years later. The lesion had grown, bled, and caused headache and disturbance of consciousness 2 years after the initial detection. The cavernous malformation was removed surgically and pathologically verified. The patient has recovered without any neurological deficits. This is a quite rare case with cavernous malformation which appeared in a moyamoya disease patient. The association of the two different vascular disorders in a young patient may suggest the existence of some interaction in the pathogenesis of these diseases. Since cavernous malformations with a de novo appearance may grow and become clinically significant, careful observation is necessary.
authors.affiliation: Department of Neurosurgery, Oita Prefectural Hospital, Bunyo 476, Oita 870-8511, Japan. korematsu-nsu@umin.ac.jp
authors.forename: Kojiro
authors.initials: K
authors.lastname: Korematsu
authors.forename: Susumu
authors.initials: S
authors.lastname: Yoshioka
authors.forename: Takashi
authors.initials: T
authors.lastname: Maruyama
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Nagai
authors.forename: Ko-Ichi
authors.initials: K
authors.lastname: Tsuji
authors.forename: Jun-Ichi
authors.initials: J
authors.lastname: Kuratsu
mesh_terms: D002528:Cerebellar Neoplasms / Q000209:etiology* / Q000473:pathology; D002648:Child; D020786:Hemangioma, Cavernous, Central Nervous System / Q000209:etiology* / Q000473:pathology; D006801:Humans; D008297:Male; D009072:Moyamoya Disease / Q000150:complications*