title: Ameliorating effect of emodin, a constitute of Polygonatum multiflorum, on cycloheximide-induced impairment of memory consolidation in rats.
abstract: The aim of the present study was intended to investigate the ameliorating effects of emodin on memory consolidation via cholinergic, serotonergic and GABAergic neuronal systems in rats. First, we evaluated the ameliorating effects of emodin on cycloheximide (CXM)-induced impairment of passive avoidance response in rats. Secondly, we clarified the role of cholinergic, serotonergic or GABAergic system on the ameliorating effect of emodin by using 5-HT1A receptor partial agonist, 5-HT2 receptor antagonist, GABAB agonist, GABAA antagonist and muscarinic receptor antagonist. Emodin protected the rat from CXM-induced memory consolidation impairment. The beneficial effect of emodin on CXM-induced memory consolidation impairment was amplified by 8-OH-DPAT (5-HT1A receptor partial agonist) and ritanserin (5-HT2 receptor antagonist), but reduced by scopolamine. These results suggested that the beneficial effect of emodin on CXM-induced memory consolidation impairment was amplified by serotonergic 5-HT1A-receptor partial agonist and 5-HT2 receptor antagonist but reduced by muscarinic receptor antagonist.
authors.affiliation: Post-Baccalaureate School of Chinese Medicine, China Medical University, Taichung, Taiwan, ROC.
authors.forename: Ming-Chin
authors.initials: MC
authors.lastname: Lu
authors.forename: Ming-Tsuen
authors.initials: MT
authors.lastname: Hsieh
authors.forename: Chi-Rei
authors.initials: CR
authors.lastname: Wu
authors.forename: Hao-Yuan
authors.initials: HY
authors.lastname: Cheng
authors.forename: Chia-Chang
authors.initials: CC
authors.lastname: Hsieh
authors.forename: Yao-Tung
authors.initials: YT
authors.lastname: Lin
authors.forename: Wen-Huang
authors.initials: WH
authors.lastname: Peng
mesh_terms: D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000008:administration & dosage / Q000494:pharmacology; D000284:Administration, Oral; D000818:Animals; D001418:Baclofen / Q000008:administration & dosage / Q000494:pharmacology; D001640:Bicuculline / Q000008:administration & dosage / Q000494:pharmacology; D003513:Cycloheximide / Q000008:administration & dosage / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D004642:Emodin / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D018755:GABA Agonists / Q000008:administration & dosage / Q000494:pharmacology; D018756:GABA Antagonists / Q000008:administration & dosage / Q000494:pharmacology; D007279:Injections, Subcutaneous; D007858:Learning / Q000187:drug effects; D008297:Male; D008568:Memory / Q000187:drug effects*; D008569:Memory Disorders / Q000139:chemically induced / Q000517:prevention & control*; D018517:Plant Roots / Q000737:chemistry; D031384:Polygonatum / Q000737:chemistry*; D011500:Protein Synthesis Inhibitors / Q000008:administration & dosage / Q000633:toxicity; D051381:Rats; D017207:Rats, Sprague-Dawley; D016713:Ritanserin / Q000008:administration & dosage / Q000494:pharmacology; D012601:Scopolamine / Q000008:administration & dosage / Q000494:pharmacology; D058825:Serotonin 5-HT1 Receptor Agonists; D058830:Serotonin 5-HT2 Receptor Antagonists
chemical_list: D018755:GABA Agonists; D018756:GABA Antagonists; D011500:Protein Synthesis Inhibitors; D058825:Serotonin 5-HT1 Receptor Agonists; D058830:Serotonin 5-HT2 Receptor Antagonists; D016713:Ritanserin; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D003513:Cycloheximide; D012601:Scopolamine; D001418:Baclofen; D004642:Emodin; D001640:Bicuculline