Activities of respiratory chain complexes in isolated platelets in females with anorexia nervosa.
OBJECTIVE
A broad spectrum of endocrine and biochemical disturbances was observed in patients with anorexia nervosa. In addition, metabolic changes may concern the efficiency of mitochondrial energy generating system. In our study we analyzed the activities of respiratory chain complexes in females with anorexia nervosa.


METHODS
The activities of respiratory chain complexes I, II, IV, I + III, and citrate synthase serving as the control enzyme were measured spectrophotometrically in isolated platelets in 36 females with anorexia nervosa (BMI 15 +/- 1.7) at the age 18-35 years and in 37 age related female controls (BMI 21 +/- 2.2).


RESULTS
In females with anorexia nervosa, the activities of respiratory chain complexes I and II in isolated platelets were significantly higher in comparison with controls. No differences were found in the activities of complexes IV and I + III and citrate synthase.


CONCLUSIONS
Our results suggest higher efficiency of some respiratory chain complexes in platelets in females with anorexia nervosa.
Böhm
Marek
M
Centre of Applied Genomic, Department of Pediatrics, Faculty of Medicine, Charles University, Ke Karlovu 2, 128 08 Prague, Czech Republic.
Papezova
Hana
H
Hansikova
Hana
H
Wenchich
Laszlo
L
Zeman
Jiri
J
D000293:Adolescent; D000328:Adult; D000856:Anorexia Nervosa / Q000097:blood*; D001792:Blood Platelets / Q000378:metabolism*; D016022:Case-Control Studies; D045222:Electron Transport Chain Complex Proteins / Q000097:blood*; D005260:Female; D006801:Humans
D045222:Electron Transport Chain Complex Proteins