title: Functional consequences of new exon acquisition in mammalian chromodomain Y-like (CDYL) genes.
abstract: The origin of new exons is an important mechanism for proteome diversity. Here, we report the recurrent origination of new exons in mammalian chromodomain Y-like (CDYL) genes and the functional consequences associated with the acquisition of the new exons. Driven by positive selection, the newly evolved longer peptide exhibits weaker transcription repression activity and attenuates the repression activity of the old form, suggesting that the acquisition of the new exons is functionally significant.
authors.affiliation: CAS-Max Planck Junior Research Group, Key Laboratory of Cellular and Molecular Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences (CAS), Kunming, Yunnan 650223, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Li
authors.forename: Jing
authors.initials: J
authors.lastname: Liang
authors.forename: Haijing
authors.initials: H
authors.lastname: Yu
authors.forename: Bing
authors.initials: B
authors.lastname: Su
authors.forename: Chunjie
authors.initials: C
authors.lastname: Xiao
authors.forename: Yongfeng
authors.initials: Y
authors.lastname: Shang
authors.forename: Wen
authors.initials: W
authors.lastname: Wang
mesh_terms: D000818:Animals; D056970:Co-Repressor Proteins; D004285:Dogs; D019143:Evolution, Molecular; D005091:Exons; D049810:Genetic Speciation; D014644:Genetic Variation; D006367:HeLa Cells; D006801:Humans; D006836:Hydro-Lyases; D051379:Mice; D008954:Models, Biological; D016254:Mutagenesis, Insertional / Q000502:physiology*; D010802:Phylogeny; D017434:Protein Structure, Tertiary / Q000235:genetics; D011506:Proteins / Q000235:genetics*; D012641:Selection, Genetic
chemical_list: D056970:Co-Repressor Proteins; D011506:Proteins; C118458:CDYL protein, human; D006836:Hydro-Lyases