title: Transmission of Panton-Valentine leukocidin-positive Staphylococcus aureus between patients with cystic fibrosis.
abstract: Panton-Valentine leukocidin-producing Staphylococcus aureus is an emerging pathogen world-wide, causing necrotizing lung infections in otherwise healthy individuals. We describe 2 episodes of patient-to-patient transmission of Panton-Valentine leukocidin-producing S. aureus, resulting in acute, life-threatening pulmonary complications in patients with cystic fibrosis. Appropriate infection control measures may be warranted to prevent similar episodes.
authors.affiliation: Department of Pediatrics, St. Louis Children's Hospital, St. Louis, Missouri, USA. elizur_a@kids.wustl.edu
authors.forename: Arnon
authors.initials: A
authors.lastname: Elizur
authors.forename: Rachel C
authors.initials: RC
authors.lastname: Orscheln
authors.forename: Thomas W
authors.initials: TW
authors.lastname: Ferkol
authors.forename: W Michael
authors.initials: WM
authors.lastname: Dunne
authors.forename: Gregory A
authors.initials: GA
authors.lastname: Storch
authors.forename: Carolyn L
authors.initials: CL
authors.lastname: Cannon
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001427:Bacterial Toxins / Q000096:biosynthesis*; D002675:Child, Preschool; D016358:Contact Tracing; D003550:Cystic Fibrosis / Q000150:complications* / Q000175:diagnosis; D018562:Disease Transmission, Infectious; D005098:Exotoxins / Q000096:biosynthesis*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007956:Leukocidins / Q000096:biosynthesis*; D008297:Male; D016106:Methicillin Resistance; D018410:Pneumonia, Bacterial / Q000382:microbiology* / Q000635:transmission*; D018570:Risk Assessment; D012720:Severity of Illness Index; D035781:Siblings; D013203:Staphylococcal Infections / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology* / Q000635:transmission*; D013211:Staphylococcus aureus / Q000302:isolation & purification; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D001427:Bacterial Toxins; D005098:Exotoxins; D007956:Leukocidins; C078284:Panton-Valentine leukocidin