title: [Comparative study between the Mitsuda test and the human leukocyte antigens in leprosy patients].
abstract: In this study, we aimed to compare the Mitsuda skin test with the alleles HLA-DR2/HLA-DR3 and HLA-DQ1, in relation to the clinical forms of leprosy in 176 patients (50 TT, 50 LL and 76 B). The results obtained did not reveal any association between the Mitsuda reaction and the HLA alleles in the clinical forms isolated. However, when analyzed according to Mitsuda test response, a significant association was found between patients with negative Mitsuda reaction and HLA-DQ1 (p=0.002). No association was observed between positive Mitsuda reaction and the HLA-DR2/DR3 alleles. We concluded that the allele HLA-DQ1 has an important participation when there is no response to the Mitsuda test. We suggest that more specific studies should be developed on this allele.
authors.affiliation: Instituto Lauro de Souza Lima, Bauru, SP. fsouza@ilsl.br
authors.forename: Fabiana Covolo
authors.initials: FC
authors.lastname: de Souza
authors.forename: Elaine Valim Camarinha
authors.initials: EV
authors.lastname: Marcos
authors.forename: Somei
authors.initials: S
authors.lastname: Ura
authors.forename: Paula Araújo
authors.initials: PA
authors.lastname: Opromolla
authors.forename: Maria Esther Salles
authors.initials: ME
authors.lastname: Nogueira
mesh_terms: D000483:Alleles; D006681:HLA-D Antigens / Q000235:genetics / Q000276:immunology*; D006683:HLA-DQ Antigens / Q000235:genetics / Q000276:immunology; D015802:HLA-DR2 Antigen / Q000235:genetics / Q000276:immunology; D015803:HLA-DR3 Antigen / Q000235:genetics / Q000276:immunology; D006801:Humans; D007918:Leprosy / Q000276:immunology*; D010641:Phenotype; D016133:Polymerase Chain Reaction; D012882:Skin Tests / Q000379:methods*
chemical_list: D006681:HLA-D Antigens; D006683:HLA-DQ Antigens; D015802:HLA-DR2 Antigen; D015803:HLA-DR3 Antigen