title: Prevention of Alzheimer's disease and dementia. Major findings from the Kungsholmen Project.
abstract: The aging of the population is a worldwide phenomenon, and studying age-related diseases has become a relevant issue from both a scientific and a public health perspective. This review summarises the major findings concerning prevention of Alzheimer's disease (AD) and other dementias from a population-based study, the Kungsholmen Project. The study addresses risk- and protective factors for AD and dementia from a lifetime perspective: at birth, during childhood, in adult life, and in old age. Although many aspects of the dementias are still unclear, some risk factors have been identified and interesting hypotheses have been suggested for other putative risk or protective factors. At the moment it is also possible to delineate some preventative strategies for dementia.
authors.affiliation: Karolinska Institutet, Aging Research Center, Division of Geriatric Epidemiology, NVS, and Stockholm Gerontology Research Center, Gävlegatan 16, S-113 30 Stockholm, Sweden. Laura.Fratiglioni@ki.se
authors.forename: Laura
authors.initials: L
authors.lastname: Fratiglioni
authors.forename: Bengt
authors.initials: B
authors.lastname: Winblad
authors.forename: Eva
authors.initials: E
authors.lastname: von Strauss
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000503:physiopathology / Q000517:prevention & control*; D015331:Cohort Studies; D003704:Dementia / Q000503:physiopathology / Q000517:prevention & control*; D004522:Educational Status; D015577:Geriatric Assessment; D006801:Humans; D008019:Life Style; D011159:Population Surveillance; D011322:Primary Prevention; D018570:Risk Assessment; D012959:Socioeconomic Factors