[The role of chemokines in uveitis].
Inflammation is part of the physiological process that aims at repairing the damage produced by different causes such as infection, trauma, and autoimmune disease. However, when this physiological process is not regulated, it can contribute to the increase in tissue damage. Chemokines and their receptors are major factors involved in the process of cell migration into inflamed tissues. In the ocular diseases, mainly in uveitis, such proteins have been identified as important mediators of the inflammation process. This review discusses the role of chemokines in several ocular diseases, with emphasis on the uveitic process.
Gonçalves
Roberto Martins
RM
Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil. robertomgoncalves@gmail.com
Teixeira
Antônio Lúcio
AL
Campos
Wesley Ribeiro
WR
Oréfice
Fernando
F
D000818:Animals; D018925:Chemokines / Q000502:physiology*; D006801:Humans; D018836:Inflammation Mediators; D019707:Receptors, Chemokine / Q000502:physiology; D014605:Uveitis / Q000503:physiopathology*
D018925:Chemokines; D018836:Inflammation Mediators; D019707:Receptors, Chemokine