title: Multifocal Scedosporium apiospermum spondylitis in a cystic fibrosis patient.
abstract: We report the first case of multifocal Scedosporium apiospermum spondylitis in a cystic fibrosis patient. The infection, which occurred during voriconazole prophylaxis, disseminated contiguously from the base of the left lung and pleura and spread to vertebrae via the epidural space. S. apiospermum osteoarticular infections are rare, and are difficult to diagnose and cure because of their resistance to anti-fungal drugs.
authors.affiliation: Université René Descartes, Hôpital Cochin APHP, service de rhumatologie B, 27 rue du faubourg Saint Jacques, 75679 Paris cedex 14, France.
authors.forename: S
authors.initials: S
authors.lastname: Guignard
authors.forename: D
authors.initials: D
authors.lastname: Hubert
authors.forename: B
authors.initials: B
authors.lastname: Dupont
authors.forename: P
authors.initials: P
authors.lastname: Anract
authors.forename: D
authors.initials: D
authors.lastname: Alioua
authors.forename: H
authors.initials: H
authors.lastname: Guerini
authors.forename: A
authors.initials: A
authors.lastname: Paugam
authors.forename: M
authors.initials: M
authors.lastname: Dougados
mesh_terms: D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use*; D000077336:Caspofungin; D003550:Cystic Fibrosis / Q000150:complications* / Q000382:microbiology; D004359:Drug Therapy, Combination; D054714:Echinocandins / Q000627:therapeutic use; D006801:Humans; D016867:Immunocompromised Host; D055666:Lipopeptides; D008297:Male; D008271:Mycetoma / Q000188:drug therapy*; D010998:Pleurisy / Q000150:complications* / Q000382:microbiology; D011743:Pyrimidines / Q000627:therapeutic use; D021681:Scedosporium / Q000187:drug effects / Q000472:pathogenicity*; D013166:Spondylitis / Q000150:complications / Q000188:drug therapy / Q000382:microbiology*; D013904:Thoracic Vertebrae / Q000382:microbiology*; D014230:Triazoles / Q000627:therapeutic use; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D011743:Pyrimidines; D014230:Triazoles; D000077336:Caspofungin; D065819:Voriconazole