title: Hemocompatibility of a hydrodynamic levitation centrifugal blood pump.
abstract: A noncontact type centrifugal pump without any complicated control or sensing modules has been developed as a long-term implantable artificial heart. Centrifugal pumps with impellers levitated by original hydrodynamic bearings were designed and have been modified through numerical analyses and in vitro tests. The hemolysis level was reduced by changing the pressure distribution around the impeller and subsequently expanding the bearing gap. Thrombus formation in the bearing was examined with in vitro thrombogenesis tests and was reduced by changing the groove shapes to increase the bearing-gap flow to 3% of the external flow. Unnecessary vortices around the vanes were also eliminated by changing the number of vanes from four to six.
authors.affiliation: Institute of Human Science and Biomedical Engineering, National Institute of Advanced Industrial Science and Technology, 1-2 Namiki, Tsukuba, 305-8564, Japan. yamane.t@aist.go.jp
authors.forename: Takashi
authors.initials: T
authors.lastname: Yamane
authors.forename: Osamu
authors.initials: O
authors.lastname: Maruyama
authors.forename: Masahiro
authors.initials: M
authors.lastname: Nishida
authors.forename: Ryo
authors.initials: R
authors.lastname: Kosaka
authors.forename: Daisuke
authors.initials: D
authors.lastname: Sugiyama
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Miyamoto
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kawamura
authors.forename: Takahisa
authors.initials: T
authors.lastname: Kato
authors.forename: Takeshi
authors.initials: T
authors.lastname: Sano
authors.forename: Takeshi
authors.initials: T
authors.lastname: Okubo
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Sankai
authors.forename: Osamu
authors.initials: O
authors.lastname: Shigeta
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Tsutsui
mesh_terms: D000818:Animals; D006354:Heart, Artificial; D006461:Hemolysis / Q000502:physiology*; D018056:Hemorheology / Q000295:instrumentation; D008422:Materials Testing; D011474:Prosthesis Design; D012756:Sheep; D013927:Thrombosis / Q000503:physiopathology*