Pathobiology of alcoholic pancreatitis.
This paper provides a summary of the effects of alcohol abuse on the pathobiologic responses that occur during acute and chronic pancreatitis considering both the human disease and animal/tissue models. The effects are multiple and include ones on cell death leading to necrosis; on inflammation resulting in a sensitized response to pancreatic stress; and fibrosis through effects of ethanol on pancreatic stellate cells and the plasminogen system. Although the effects of alcohol are multiple and complex, it is likely that a combination of a few key effects on these pathobiologic responses drive the increased sensitivity of the pancreas to acute pancreatitis with pancreatic stress and the promotion of chronic pancreatitis with pancreatic injury occurring during acute pancreatitis.
Pandol
Stephen J
SJ
Department of Medicine, University of California, Department of Veterans Affairs, Los Angeles, California, USA. stephen.pandol@va.gov
Raraty
Michael
M
D000208:Acute Disease; D000428:Alcohol Drinking / Q000009:adverse effects* / Q000378:metabolism; D006801:Humans; D019512:Pancreatitis, Alcoholic / Q000209:etiology* / Q000378:metabolism / Q000473:pathology