title: The cholesteryl ester transfer protein I405V polymorphism is associated with increased high-density lipoprotein levels and decreased risk of myocardial infarction: the Rotterdam Study.
abstract: METHODS
  The effect of the cholesteryl ester transfer protein (CETP) I405V polymorphism on lipid levels, atherosclerosis and myocardial infarction (MI) was examined in 6421 participants from the Rotterdam Study.
  
  
  METHODS
  Quantitative outcomes were studied with linear models; Cox models were used to assess MI risk.
  
  
  RESULTS
  High-density lipoprotein cholesterol (HDL) increased by 0.06 [95% confidence interval (CI): 0.03, 0.09] mmol/l in VV carriers. The V allele was further associated with decreased MI risk in men [hazard ratio (95% confidence interval)=0.57 (0.45, 0.73), VV versus II] (Ptrend=0.02).
  
  
  CONCLUSIONS
  This study provides additional evidence for the association of CETP with HDL levels and suggests that CETP is an atherogenic protein increasing the risk of MI.
authors.affiliation: Genetic Epidemiology Unit, Erasmus Medical Center, Rotterdam, The Netherlands.
authors.forename: Aaron
authors.initials: A
authors.lastname: Isaacs
authors.forename: Fakhredin A
authors.initials: FA
authors.lastname: Sayed-Tabatabaei
authors.forename: Albert
authors.initials: A
authors.lastname: Hofman
authors.forename: Ben A
authors.initials: BA
authors.lastname: Oostra
authors.forename: Olaf H
authors.initials: OH
authors.lastname: Klungel
authors.forename: Anke-Hilse
authors.initials: AH
authors.lastname: Maitland-Vander Zee
authors.forename: Bruno H Ch
authors.initials: BH
authors.lastname: Stricker
authors.forename: Jacqueline C M
authors.initials: JC
authors.lastname: Witteman
authors.forename: Cornelia M
authors.initials: CM
authors.lastname: van Duijn
mesh_terms: D050197:Atherosclerosis / Q000097:blood / Q000150:complications / Q000235:genetics; D053480:Cholesterol Ester Transfer Proteins / Q000235:genetics*; D005260:Female; D005500:Follow-Up Studies; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D015994:Incidence; D016014:Linear Models; D008075:Lipoproteins, HDL / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000453:epidemiology / Q000235:genetics*; D009426:Netherlands / Q000453:epidemiology; D011110:Polymorphism, Genetic; D011159:Population Surveillance; D016016:Proportional Hazards Models; D011446:Prospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D012737:Sex Factors; D013997:Time Factors; D015854:Up-Regulation
chemical_list: D053480:Cholesterol Ester Transfer Proteins; D008075:Lipoproteins, HDL