title: Two eudesmane sesquiterpenes from Laggera pterodonta.
abstract: Two new eudesmane sesquiterpenes, 2alpha-hydroxy pterodontic acid (1) and pterodolide [3alpha-(2-methyl-2,3-epoxy)-butyric-4alpha-acetoxy-8beta-ethoxy eudesma-7(11)-en-8alpha,12-olide (2), along with five known compounds (3-7) were isolated from the aerial parts of Laggera pterodonta. Their structures were elucidated on the basis of spectroscopic methods. The immunosuppressive activity of the isolated compounds was investigated.
authors.affiliation: R & D Centre of Zhongxin Pharmaceuticals Group Co. Ltd., Tianjin 300457, China.
authors.forename: Y-B
authors.initials: YB
authors.lastname: Liu
authors.forename: W
authors.initials: W
authors.lastname: Jia
authors.forename: Z
authors.initials: Z
authors.lastname: Yao
authors.forename: Q
authors.initials: Q
authors.lastname: Pan
authors.forename: Y
authors.initials: Y
authors.lastname: Takaishi
authors.forename: H-Q
authors.initials: HQ
authors.lastname: Duan
mesh_terms: D019659:Asteraceae / Q000737:chemistry*; D007166:Immunosuppressive Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045787:Sesquiterpenes, Eudesmane / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: C525286:2-hydroxypterodontic acid; D007166:Immunosuppressive Agents; D012717:Sesquiterpenes; D045787:Sesquiterpenes, Eudesmane; C525287:pterodolide 3-(2-methyl-2,3-epoxybutyric)-4-acetoxy-8-ethoxyeudesma-7(11)-en-8,12-olide