Metal complexes of cyclen and cyclam derivatives useful for medical applications: a discussion based on thermodynamic stability constants and structural data.
A series of the most common chelators used in magnetic resonance imaging (MRI) and in radiopharmaceuticals for medical diagnosis and tumour therapy, H(4)dota, H(4)teta, H(8)dotp and H(8)tetp, is examined from a chemical point of view. Differences between 12- and 14-membered tetraazamacrocyclic derivatives with methylcarboxylate and methylphosphonate pendant arms and their chelates with divalent first-series transition metal and trivalent lanthanide ions are discussed on the basis of their thermodynamic stability constants, X-ray structures and theoretical studies.
Delgado
Rita
R
Instituto de Tecnologia Química e Biológica, UNL, Apartado 127, 2781-901, Oeiras, Portugal. delgado@itqb.unl.pt
Félix
Vítor
V
Lima
Luís M P
LM
Price
David W
DW
D002614:Chelating Agents / Q000737:chemistry* / Q000627:therapeutic use; D000080027:Cyclams; D006571:Heterocyclic Compounds / Q000737:chemistry*; D006801:Humans; D028581:Lanthanoid Series Elements / Q000737:chemistry; D015394:Molecular Structure; D009369:Neoplasms / Q000000981:diagnostic imaging / Q000532:radiotherapy; D009942:Organometallic Compounds / Q000737:chemistry* / Q000627:therapeutic use; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000737:chemistry* / Q000627:therapeutic use; D013816:Thermodynamics; D028561:Transition Elements / Q000737:chemistry*
D002614:Chelating Agents; D000080027:Cyclams; D006571:Heterocyclic Compounds; D028581:Lanthanoid Series Elements; D009942:Organometallic Compounds; D019275:Radiopharmaceuticals; D028561:Transition Elements; C024560:cyclam; C038072:cyclen